KR20140013337A - A cosmetic composition for scalp care - Google Patents
A cosmetic composition for scalp care Download PDFInfo
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- KR20140013337A KR20140013337A KR1020120080027A KR20120080027A KR20140013337A KR 20140013337 A KR20140013337 A KR 20140013337A KR 1020120080027 A KR1020120080027 A KR 1020120080027A KR 20120080027 A KR20120080027 A KR 20120080027A KR 20140013337 A KR20140013337 A KR 20140013337A
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- moisturizing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
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Abstract
Description
The present invention relates to a cosmetic composition for protecting the scalp, and more specifically, to the skin including an amphiphilic peptide having a glycine-lysine-glycine peptide backbone, and an HGP complex component of IGF-1, PDGF, sewage extract, gosam extract, and licorice extract. The present invention relates to a cosmetic composition for protecting the scalp, which is safe without irritation and has a synergistic effect on skin moisturization and scalp improvement.
In general, the skin or scalp is affected by various factors in the external and internal environment, such as UV rays, dry winds, heat (perma and instrument straight), humidity, irritant detergents (dyeing), physical illness, and biochemical aging. Changes are made to maintain homeostasis. Functional scalp cosmetics are used to maintain the skin and scalp and to improve the skin to solve the problems of skin and scalp caused by such changes, such as dry skin, hair bleaching, hair loss, pigmentation. The structure of the skin or scalp is composed of multiple structures of the stratum corneum, epidermis, dermis and subcutaneous tissue from the outside, and the functional cosmetics play an important role to be particularly concerned with the stratum corneum. In the stratum corneum, there are intercellular lipids such as natural moisturizing factor (NMF), which contains amino acids as a main ingredient, and ceramides and phospholipids, which prevent water evaporation. It is a general tendency that the following raw material components are proposed as a factor centering on hair growth.
1) Vitamin E, Vitamin E nicotinate, Glucose Extract, Carpronium HCl, Benzylnicotinate, γ-Oryzanol
2) Topical stimulants include pepper tink, L-menthol, camphor, benzylnicotinate thymol, ginger tink
3) Vitamin A, B1, B2, B6, E and derivatives, Panthothenic acid and derivatives, Nicotinic acid, biotin, amino acids, amino acid extract, cystine, Methionine, Cysteine, Serine, Leusine, Tryptophane, Growth peptides
4) Anti-dandruff Agents include salicylic acid, Resorcine, and Resorcine monoacetate.
5) Anti-seborrheic ingredients include Sulfur, Pyridoxine Hydrochloride, Lecithine, Polysorbate
6) Disinfectant components include Hinokitiol, Benzalkonium chloride, benzotium chloride, Chlohexithine, Isopropylmethyl phenol
7) Hormones include female hormones (estradiol, ethinylestradiol)
8) Anti-inflammatory ingredients include Hydrocortisone saxetate, predinisolone, azulene, licorice and derivatives, diphenhydramine hydrochloride
9) Improvement of metabolism, hair root function, and revitalization include Panthothenylethylether, placenta ex, allantoin, Penthadecanoic acid glyceride
10) Moisturizing ingredients include glycerine, hyaluronic acid, chondroithine sulfate, 1,3-buthylene glycol
In addition, dilauroyl glutamate lysine has a peptide backbone (Glu-Lys-Glu) in which two lauroyl glutamate sodium salts, each of which is a single-chain, one hydrophilic group, are linked with lysine as a space, and show a gemini-like amphipathicity. ROSEN M, Geminis J., A NEW Generation of Surfactants, CHEMTECH, 23, 30 (1993). Dilauroylglutamic acid lysine is known to have the effect of restoring damaged skin and moisturizing skin, and to reduce skin irritation when used in combination with skin irritants (田村 幸 永, 山 脇 幸 男, 香 粧 粧 技2., 2. 25 (2007).
Many of the above-mentioned components can be explained as being determined by various mechanisms rather than as a single cause of various factors that affect hair growth and direct and indirect hair growth. The causes of hair loss can be summarized as follows.
1) Involvement of testosterone
Androgen metabolism occurs through the involvement of various enzymes in the skin.
In the hair, related metabolites such as testosterone, a male hormone produced by the prostate, and Androstendion formed by Androgen metabolism in the skin, enter the blood, reach the hair follicle cells, penetrate the cell membrane, and enter the cell.
Testosterone introduced into the cytoplasm or produced by metabolism is transformed into 5α-dehydrotestosterone (DHT), which has a stronger male hormone action by 5α-Reductase present in the cytoplasm. The 5α-DHT binds to specific receptors, enters the nucleus, fuses, affects protein synthesis, and ultimately inhibits hair growth. In addition, 5α-DHT acts as an Adenyl cyclase that activates intracellular metabolism. Inhibits and decreases the concentration of Cyclic ANP in the cell, thereby lowering the metabolism of the parent cell, thereby inhibiting energy supply.
(2) impaired blood circulation around the nipple and follicle
Hair grows according to the division, proliferation, and differentiation of hair cells, and the water and nutrients necessary for the hair are supplied through capillaries spread around the milk cells. Therefore, the development of capillaries distributed around the nipple and follicles is a very important factor for hair growth.
(3) Other causes ① Malnutrition ② Abnormality and degradation of various enzymes involved in hair growth ③ Sebaceous gland secretion disorders ④ Excessive dandruff (sebum secretion and growth factors of scalp bacteria) Inflammation compared to normal cells The epidermal cells that have risen degenerate into keratinocytes and detach. Desquamation of keratinocytes may cause pathological dandruff, which causes sebaceous membrane degeneration and decay products act on the hair follicles that communicate with the pores, causing hair follicle cells to change, and growing hairs into resting hairs. Therefore, the inflammation of the scalp needs to be removed quickly. ⑤ Excessive drying of the scalp ⑥ Scalp tension ⑦ Genetic factors.
However, the mechanisms used in the majority of commercial items have not reached a satisfactory level of hair loss prevention effect and hair growth effect.
As discussed above, various materials can be used for protecting the skin, including moisturizing or improving the skin and scalp. However, due to the limitation as a cosmetic composition that is not easy to penetrate the skin, it is not easy to see the excellent skin moisturizing and scalp improvement effect by applying the substances to the skin. Therefore, there is a constant demand for the development of a scalp cosmetic composition having improved skin and scalp improvement functional effects.
Accordingly, the present inventors have studied to develop a cosmetic composition having a better effect on skin protection including skin and scalp moisturizing, and as a result, by combining a substance known to have a skin moisturizing and scalp moisturizing effect, The present invention has been completed by discovering a remarkable effect in terms of skin protection effect.
Accordingly, it is an object of the present invention to provide a cosmetic composition for protecting the scalp hair, including improving skin moisturizing and scalp moisturizing.
Another object of the present invention is to provide a method of applying the cosmetic composition to the skin to improve skin moisturizing or hair loss of the scalp hair.
In order to achieve the above object, the present invention, dilauroyl glutamic acid lysine or its non-toxic salts, liposome form and root extract material sewage sewage extract, high ginseng extract, licorice extract stabilized growth factor of IGF-1, PDGF Provides a cosmetic composition for protecting the scalp having a HGP complex component, which is a liposome carrier carrier of nanoparticles containing the active ingredient by a critical processing extraction method.
The present invention also provides a method for improving skin moisturizing or hair loss of the scalp hair, comprising applying the cosmetic composition according to the present invention to the skin.
Hereinafter, the present invention will be described in more detail.
The cosmetic composition according to the present invention is a combination of dilauroyl glutamic acid lysine or its nontoxic salt, and IGF-1, PDGF, sewage extract, high ginseng extract, and licorice extract, which have been known for protecting skin such as moisturizing effect and wrinkle improvement. HGP complex cosmetic composition first processed by a carrier material of nanoparticles, by each combination, each component synergistically increases the protective effect of the skin and scalp moisturizing itself, which is very excellent It has a skin protective effect.
"Skin protection" as a use of the cosmetic composition according to the present invention is intended to improve the overall health of the skin, and specifically includes, but is not limited to, "moisture improvement", "wrinkle improvement", or "combination of the use", etc. It doesn't happen. Accordingly, in accordance with a preferred embodiment of the present invention, the present invention provides an HGP comprising (a) dilauroyl glutamic acid lysine or its non-toxic salt, and IGF-1, PDGF, sewage extract, gosam extract, licorice extract as active ingredients. Cosmetic composition for improving skin and scalp moisturizing of complex components, (b) dilauroyl glutamic acid lysine or its nontoxic salt, and IGF-1, PDGF, sewage extract, high ginseng extract, licorice extract as active ingredients HGP complex cosmetic composition for improving the scalp hair, (c) dilauroyl glutamic acid lysine or its non-toxic salts, and IGF-1, PDGF, sewage extract, gosam extract, licorice extract as an active ingredient HGP complex Provides a cosmetic composition for scalp moisturizing and hair loss improvement.
The non-toxic salt of dilauroyl glutamic acid lysine may be used in any salt form as long as it does not inhibit or show the toxicity of dilauroyl glutamic acid lysine, and sodium dilauroyl glutamate is particularly preferred.
The composition of the present invention preferably comprises 30.2 parts by weight of HGP complex constituting IGF-1 0.1, PDGF 0.1, sewage extract 10.0, high ginseng extract 10.0, licorice extract 10.0 parts by weight based on 100.0 parts by weight of dilauroyl glutamic acid lysine. do. The composition of the present invention may preferably comprise 0.1 to 1.0% by weight of dilauroyl glutamic acid lysine and 0.001 to 0.01% by weight of the HGP complex component of IGF-1, PDGF, sewage extract, gosam extract, licorice extract, If it is less than the above range, the skin moisturizing power and scalp moisturizing improvement effect may be weak, IGF-1, PDGF, sewage extract, high ginseng extract, licorice extract HGP complex component of 100 parts by weight of dilauroyl glutamic acid lysine In the case of exceeding the above range, the cosmetic composition is not appropriate in terms of stability due to the roughness and stiffness of the surface.
The composition of the present invention may be prepared in a specific formulation by a method well known in the cosmetic field, and may further include a cosmetically acceptable additive. Such additives include, but are not limited to, stabilizers, solubilizers, emulsions, vitamins, pigments, fragrances, or combinations thereof, and may vary depending on the type of formulation to be prepared.
The scalp protective cosmetic composition of the present invention may be prepared in any formulation conventionally prepared in the art, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, shampoos, surfactant-containing cleansing, Tonic, scaling, etc. may be formulated, but is not limited thereto. More specifically, it may be prepared in a formulation such as softening lotion, nourishing lotion, nutrient latex, nourishing cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, hair essence, rinse.
When the formulation of the present invention is a solution or an emulsion, a solvent, a solubilizing agent or an emulsifying agent is used as a carrier component, and examples thereof include water, ethanol, carboxyl vinyl polymer, propylene glycol, 1,3-butylene glycol, Esters, polyethylene hardened castor oil, preservatives or sorbitan fatty acid esters.
When the formulation of the present invention is a suspension, the carrier component may include water, a flavoring agent, a liquid diluent such as concentrated glycerin, butylene glycol or propylene glycol, ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester, or polyoxyethylene sorbitan Emulsifying suspending agents such as esters, microcrystalline cellulose, carboxyvinyl polymer, thickener or preservative can be used.
In the case where the formulation of the present invention is a surfactant-containing cleansing, the carrier component is an aliphatic alcohol sulfate, an aliphatic alcohol ether sulfate, a sulfosuccinic acid monoester, an isethionate, an imidazolinium derivative, a methyltaurate, a sarcosinate, a fatty acid amide ether. Sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives, ethoxylated glycerol fatty acid esters, and the like.
The cosmetic composition according to the present invention, as confirmed by the experiment in the following examples, skin moisturizing of HGP complex component by the combination of dilauroyl glutamic acid lysine and IGF-1, PDGF, sewage extract, gosam extract, licorice extract and It has a synergistic effect in improving scalp moisturization. In addition, the cosmetic composition according to the present invention can be used safely as a cosmetic since the skin irritation is extremely low.
Therefore, in another aspect, the present invention provides a method for improving skin moisturizing or scalp moisturizing by applying the cosmetic composition according to the present invention to the skin.
The cosmetic composition of the present invention may be applied by applying an appropriate amount to the skin according to the skin area to be applied, and may be used once to several times a day as needed. The amount and frequency of application can be increased or decreased as necessary according to the skin condition, age, etc. of the individual.
As described above, the scalp protective cosmetic composition according to the present invention improves the skin moisturizing and scalp moisturizing of HGP complex component by the combination combination of dilauroyl glutamic acid lysine and IGF-1, PDGF, sewage extract, high ginseng extract, licorice extract It has a synergistic effect on the skin and has almost no skin irritation, and it is excellent for keeping the skin and scalp healthy. In addition, the cosmetic composition has the effect of delaying de-aging by the moisturizing effect and hair loss improving effect, it can be used as functional cosmetics for skin moisturizing, scalp moisturization improvement, and scalp de-aging prevention.
Hereinafter, the present invention will be described in more detail with reference to examples. However, these examples are for illustrative purposes only, and the scope of the present invention is not limited to these examples.
Example 1 Preparation of Hair Lotion
As shown in Table 1, 0.05% by weight of carboxyvinyl polymer, 1.0% by weight of butylene glycol, 0.5% by weight of glycerin, 1.0% by weight of sodium dilauroyl glutamate, IGF-1, PDGF, sewage extract, high ginseng extract, Mixture of Licorice Extract 0.302% by weight of the HGP complex component and 0.5% by weight of PEG 4000 were heated and mixed and dissolved in purified water to prepare an aqueous mixture. Then, 0.2% by weight of polyoxyethylene cured castor oil, 0.2% by weight of polysorbate 80, 0.05% by weight of triethanolamine, methylparaben amount, and perfume amount in 18.0% by weight of ethanol were mixed with the aqueous mixture to make up the lotion. Prepared.
[Table 1]
Comparative Examples 1,2, and 3: Preparation of Hair Lotion
Except for using the composition ratio shown in Table 1 in Example 1 was carried out in the same manner as in Example 1, to prepare a lotion of Comparative Examples 1, 2, and 3.
Example 2 Hair Nutrient Preparation
As shown in Table 2, 0.5 wt% vegetable wax, 0.5 wt% cetanol, 0.8 wt% cetostearyl alcohol, 0.6 wt% stearic acid, 0.6 wt% self-emulsifying monostearic acid, 0.5 wt% lipophilic monostearic acid, 0.50% by weight of beeswax, 0.5% by weight of paraffin wax, 3.0% by weight of squalane, 1.2% by weight of polysorbate 60, 0.8% by weight of sesquioleic acid, and fragrance were separately mixed to heat and dissolved to prepare an alcohol mixture.
Then, 0.1% by weight of the HGP complex component, 1.0% by weight of sodium dilauroylglutamic acid lysine, 0.5% by weight of PEG 4000, 4.00% by weight of concentrated glycerin, 6.00% by weight of butylene glycol, 0.08% by weight of carboxypolymer, 0.08% by weight of triethanolamine %, An appropriate amount of preservative, and the remaining amount of purified water were mixed and heated to dissolve the mixture, followed by stirring and cooling to prepare a nutrient emulsion.
[Table 2]
Comparative Examples 4, 5, and 6: Preparation of Nutrient Milk
The nutrient emulsions of Comparative Examples 4, 5, and 6 were prepared in the same manner as in Example 2, except that the composition ratios shown in Table 2 were used in Example 2.
Example 3: Hair Treatment Preparation
As shown in Table 3 below, 1.0 wt% vegetable wax, 0.9 wt% cetanol, 1.00 wt% cetostearyl alcohol, 0.8 wt% stearic acid, 1.0 wt% self-emulsifying monostearic acid, 1.00 wt% lipophilic monostearic acid, 1.50 wt% beeswax, 6.00 wt% squalane, 0.5 wt% paraffin wax, 3.00 wt% capric caprylic triglyceride, 0.50 wt% dimethicone, 1.20 wt% polysorbate, 0.8 wt% sorbitan stearate, and The fragrance was separately mixed and heated to prepare an alcohol mixture.
Then, 1.0% by weight of the HGP complex component, 0.5% by weight of PEG 4000, 5.0% by weight of sodium dilauroyl glutamate, 6.00% by weight of concentrated glycerin, 6.00% by weight of butylene glycol, 0.1% by weight of carboxyvinyl polymer, 0.10% of triethanolamine A weight treatment and a suitable amount of preservative were mixed with the remaining amount of purified water and heated to dissolve the mixture, followed by stirring and cooling to prepare a hair treatment.
Comparative Examples 7, 8, and 9: Hair Treatment Preparation
Except for using the composition ratio shown in Table 3 in Example 3 was carried out in the same manner to prepare the hair treatment of Comparative Examples 7, 8, and 9.
[Table 3]
Experimental Example 1 Measurement of Moisturizing Force Using Coneometer CM 825
The moisturizing effect was measured using the Coneometer CM 825 (Corneometer CM 825, Courage + Khazaka) for the Examples and Comparative Example compositions. Five women in their 35s and 60s in each sample were divided into 8 x 2 cm 2 upper arms and 8 compartments, and washed several times with water to remove moisture without stimulation. After 15 minutes, the samples were applied evenly by dropping 10 µl into each of the two sections. After 2 hours, measurements were made 5 times per compartment using a coneometer. The experiment was conducted in a constant temperature and humidity room with a room temperature of 21 ± 2 ° C. and a relative humidity of 50 ± 5%. The measured value was used by averaging the value obtained by measuring five times, it is shown in Table 4 using the average value of five subjects. Table 4 shows the increase in the moisturizing power of Example 1, Comparative Examples 2, 3 for Comparative Example 1 to compare the increase in the moisturizing power of Example 1, Comparative Examples 2, 3 with respect to Comparative Example 1. In addition, Example 2, Comparative Examples 4-6, Example 3, and Comparative Example 7-9 are also shown in the same manner.
[Table 4]
-How to calculate moisturizing power
①Corneometer Value = S-ΔS
S: Corneometer Value,
ΔS: Corneometer Value 2 hours after sample application
② increased moisturizing power = Example moisturizing power-Comparative Example moisturizing power (1, 4, or 7)
Moisturizing Power of Comparative Example (2,3)-Moisturizing Power of Comparative Example 1
Moisturizing Power of Comparative Example (5,6)-Moisturizing Power of Comparative Example 4
Moisturizing Power of Comparative Example (8,9)-Moisturizing Power of Comparative Example 7
In Examples 1 to 3, the increase and decrease by using both of sodium dilauroyl glutamic acid lysine and HGP complex component were used in Comparative Examples 2, 3, 5, 6, 8, and 9, respectively. Moisturizing increases and decreases. The increase in the moisturizing power of each of Examples 1, 2 and 3 is superior to the sum of the increase in the moisturizing power of Comparative Examples 2 and 3, the sum of the increase in the moisturizing power of Comparative Examples 5 and 6 and the increase in the moisturizing power of Comparative Examples 8 and 9, respectively. Was derived. Therefore, in terms of increasing the moisturizing power, it can be said that the formulation of Examples 1-3 of the present invention has a synergistic effect compared to the case of using sodium dilauroyl glutamic acid lysine or HGP complex component, respectively.
Experimental Example 2: Measurement of moisturizing power using a desiccator
For the Examples and Comparative Examples, the moisturizing effect was measured using the difference in the rate of moisture evaporation in the liquid phase as follows, and 30% of the Examples or Comparative Example formulations were dissolved in purified water, respectively.
After 10 g of the sample was titrated into a cup with a constant surface area, it was left for 24 hours in a desiccator adjusted to a temperature of 35 ° C. using completely dried calcium chloride (CaCl 2 ) as an absorbent, and each sample was weighed 5 times after 24 hours. Moisturizing power was measured using the measured average value. The results are shown in Table 5.
[Table 5]
Calculation method
① Moisturizing power (%) = (1-ΔS / S) × 100
S: weight of initial sample
ΔS: initial sample weight-final sample weight
② Moisture increase rate = Example / Comparative example (1, 4, 7) X 100%
Comparative Example (2,3,5,6,8,9) / Comparative Example (1,4,7) X 100%
According to the experimental results, the moisturizing power increase rate of Example 1 is greater than the sum of the increase rates of Comparative Examples 2, 3, the moisturizing power increase rate of Example 2 is greater than the sum of the increase rates of Comparative Examples 5, 6, the moisturizing power increase rate of Example 3 Was greater than the sum of the increase rates of Comparative Examples 8 and 9. Therefore, the formulations of Examples 1, 2, and 3 using both sodium dilauroyl glutamic acid lysine and HGP complex components have synergistic effects on the moisturizing effect compared to the comparative examples when used alone. Indicated.
Experimental Example 3. Improvement of hair loss
Hair loss improvement effect was measured using the composition prepared in Examples 1, 2, 3 and Comparative Examples 1-9.
Twenty women aged 35 to 60 years were applied twice a day to the cosmetic compositions prepared in Examples 1, 2 and 3 and Comparative Examples 1-9 evenly on the scalp, and applied for 2-3 minutes. After washing, the number of hair dropouts was measured, and the total daily value was summed up for a total of three months to obtain an average daily value.
To 60 scalp of each subject was applied the cosmetic composition prepared in Examples 1, 2, 3, 180 was applied to the cosmetic composition prepared in Comparative Example 1-9. After applying twice a day for three months, the degree of hair loss relief of scalp hair was obtained by grasping the amount of hair loss and obtaining an average value of one day.
TABLE 6
Criteria
(-) No improvement: 0, Hair loss (80 or more) (1 day ~ 90 days total) / 90 days
(-+) Slight improvement: 1, Hair loss (50-79)
(+) Medium improvement: 2, hair loss (30 to 49)
(++) Good improvement: 3 Hair loss (10-29)
Rate of improvement = {[(+-) number × 1] + [(+) number × 2] + [(++) number × 3]} / number of subjects
According to Table 6, the improvement rate of the wrinkles is greater than the sum of the improvement rate increase for Comparative Example 1 of Comparative Example 1, Comparative Example 1 of Example 1, the improvement rate of Comparative Example 4 of Example 2 The increase is greater than the sum of the improvement rate for Comparative Example 4 of Comparative Examples 5 and 6, and the increase rate of improvement for Comparative Example 7 of Example 3 is greater than the sum of the improvement rate for Comparative Example 7 of Comparative Examples 8 and 9. appear. Therefore, the formulations of Examples 1, 2, and 3 using both sodium dilauroyl glutamic acid lysine and HGP complex components each have a synergistic effect in anti-wrinkle effect compared to the comparative examples when used alone. It is shown.
. Therefore, the formulations of Examples 1, 2, and 3, which use both sodium dilauroyl glutamate and HGP complex components, respectively, have increased skin moisturization and an increase in hair loss reduction rate compared to the comparative examples when used alone. It is shown to have an effective effect.
Experimental Example 3: Skin Safety Measurement
In order to evaluate the skin safety through the skin patch of the cosmetic composition prepared in Examples 1, 2, 3 and Comparative Examples 2, 3, 5, 6, 8, 9, the following experiment was performed. A total of 90 women (90 women) who had experienced skin side effects from cosmetics were applied to the patient's back with a cosmetic composition containing the cosmetic composition, and after removing the patch for 48 hours, 1 hour Primary determinations were made after 2 hours and after 72 hours and 96 hours, and the results are shown in Table 8 below.
[Table 8]
Criteria
-: No erythema or unusual phenomenon
+-: Slightly reddish
+: Significantly redder than the surroundings
++: reddening and swelling worse than the surroundings
Stimulus = {[(+-) Number × 1] + [(+) Number × 2] + [(++) Number × 3]} / Number of Subjects
According to Table 8, Examples 1, 2, and 3 according to the present invention are slightly safer than the cosmetic compositions prepared in Comparative Examples 2, 3, 5, 6, 8, and 9, and both the compositions of the Examples and the Comparative Example compositions are Significantly safe for skin.
Claims (9)
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