KR20140010929A - 인공보철 조직 판막 - Google Patents
인공보철 조직 판막 Download PDFInfo
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- KR20140010929A KR20140010929A KR1020137005555A KR20137005555A KR20140010929A KR 20140010929 A KR20140010929 A KR 20140010929A KR 1020137005555 A KR1020137005555 A KR 1020137005555A KR 20137005555 A KR20137005555 A KR 20137005555A KR 20140010929 A KR20140010929 A KR 20140010929A
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/22—Valves or arrangement of valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Prostheses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/875,727 US8257434B2 (en) | 2007-12-18 | 2010-09-03 | Prosthetic tissue valve |
| US12/875,727 | 2010-09-03 | ||
| PCT/US2011/050019 WO2012030996A1 (en) | 2010-09-03 | 2011-08-31 | Prosthetic tissue valve |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20140010929A true KR20140010929A (ko) | 2014-01-27 |
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|---|---|---|---|
| KR1020137005555A Withdrawn KR20140010929A (ko) | 2010-09-03 | 2011-08-31 | 인공보철 조직 판막 |
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| Country | Link |
|---|---|
| US (4) | US8257434B2 (enExample) |
| EP (1) | EP2611390A4 (enExample) |
| JP (1) | JP2013539392A (enExample) |
| KR (1) | KR20140010929A (enExample) |
| AU (1) | AU2011295982B2 (enExample) |
| BR (1) | BR112013005180A2 (enExample) |
| CA (1) | CA2810008A1 (enExample) |
| SG (1) | SG187985A1 (enExample) |
| WO (1) | WO2012030996A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20220117089A (ko) | 2021-02-16 | 2022-08-23 | 재단법인 아산사회복지재단 | 인조혈관 복합물 |
| KR20220126495A (ko) | 2021-03-09 | 2022-09-16 | 재단법인 아산사회복지재단 | 인조혈관 크기 책정기 및 그 측정방법 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8257434B2 (en) | 2007-12-18 | 2012-09-04 | Cormatrix Cardiovascular, Inc. | Prosthetic tissue valve |
| US8679176B2 (en) | 2007-12-18 | 2014-03-25 | Cormatrix Cardiovascular, Inc | Prosthetic tissue valve |
| AU2010216095B2 (en) | 2009-02-18 | 2015-10-08 | Cormatrix Cardiovascular, Inc. | Compositions and methods for preventing cardiac arrhythmia |
| WO2010102185A2 (en) | 2009-03-06 | 2010-09-10 | Biomedical Device Consultants and Laboratories of Colorado, LLC | Fatigue testing system for prosthetic devices |
| GB2497475B (en) * | 2010-10-01 | 2017-04-19 | Cook Biotech Inc | Kits for tissue reconstruction |
| CA3035048C (en) | 2010-12-23 | 2021-05-04 | Mark Deem | System for mitral valve repair and replacement |
| EP2714099A4 (en) | 2011-05-27 | 2014-11-19 | Cormatrix Cardiovascular Inc | STERILIZED, ACELLULAR EXTRACELLULAR MATRIX COMPOSITIONS AND METHODS OF MAKING SAME |
| CA2840084C (en) | 2011-06-21 | 2019-11-05 | Foundry Newco Xii, Inc. | Prosthetic heart valve devices and associated systems and methods |
| US11202704B2 (en) | 2011-10-19 | 2021-12-21 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
| CA2849030C (en) | 2011-10-19 | 2020-10-27 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
| US9763780B2 (en) | 2011-10-19 | 2017-09-19 | Twelve, Inc. | Devices, systems and methods for heart valve replacement |
| US9039757B2 (en) | 2011-10-19 | 2015-05-26 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
| EP4252714B1 (en) | 2011-10-19 | 2025-08-13 | Twelve, Inc. | Device for heart valve replacement |
| US9655722B2 (en) | 2011-10-19 | 2017-05-23 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
| US9579198B2 (en) | 2012-03-01 | 2017-02-28 | Twelve, Inc. | Hydraulic delivery systems for prosthetic heart valve devices and associated methods |
| CN105188599B (zh) | 2013-02-08 | 2017-12-26 | 玛芬股份有限公司 | 外周密封静脉止回瓣膜 |
| JP2016512989A (ja) | 2013-03-01 | 2016-05-12 | コーマトリックス カーディオバスキュラー, インコーポレイテッドCorMatrix Cardiovascular, Inc. | ツーピース人工弁 |
| US9044319B2 (en) * | 2013-03-01 | 2015-06-02 | Cormatrix Cardiovascular, Inc. | Anchored cardiovascular valve |
| EP3427696B1 (en) | 2013-03-01 | 2025-07-02 | Cormatrix Cardiovascular, Inc. | Anchored cardiovascular valve |
| US9636222B2 (en) | 2013-03-12 | 2017-05-02 | St. Jude Medical, Cardiology Division, Inc. | Paravalvular leak protection |
| US9308084B2 (en) | 2013-05-03 | 2016-04-12 | Cormatrix Cardiovascular, Inc | Prosthetic tissue valves and methods for anchoring same to cardiovascular structures |
| CN108272536B (zh) | 2013-05-20 | 2020-03-03 | 托尔福公司 | 可植入心脏瓣膜装置、二尖瓣修复装置以及相关系统和方法 |
| EP2853237A1 (en) * | 2013-09-25 | 2015-04-01 | Universität Zürich | Biological heart valve replacement, particularly for pediatric patients, and manufacturing method |
| CA2943182A1 (en) | 2014-03-21 | 2015-09-24 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods for preparation of a terminally sterilized hydrogel derived from extracellular matrix |
| US10111749B2 (en) | 2014-06-11 | 2018-10-30 | Medtronic Vascular, Inc. | Prosthetic valve with flow director |
| US9662203B2 (en) | 2014-06-11 | 2017-05-30 | Medtronic Vascular, Inc. | Prosthetic valve with vortice-inducing baffle |
| US9238090B1 (en) | 2014-12-24 | 2016-01-19 | Fettech, Llc | Tissue-based compositions |
| EP3337428B1 (en) | 2015-08-21 | 2024-09-25 | Twelve Inc. | Mitral valve repair devices |
| AU2017207015B2 (en) | 2016-01-13 | 2022-08-04 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Vascular extracellular matrix hydrogel |
| EP3448316B1 (en) | 2016-04-29 | 2023-03-29 | Medtronic Vascular Inc. | Prosthetic heart valve devices with tethered anchors |
| WO2018013361A1 (en) | 2016-07-11 | 2018-01-18 | Cormatrix Cardiovascular, Inc. | Prosthetic tissue valves |
| US10653523B2 (en) | 2017-01-19 | 2020-05-19 | 4C Medical Technologies, Inc. | Systems, methods and devices for delivery systems, methods and devices for implanting prosthetic heart valves |
| US10561495B2 (en) | 2017-01-24 | 2020-02-18 | 4C Medical Technologies, Inc. | Systems, methods and devices for two-step delivery and implantation of prosthetic heart valve |
| US12029647B2 (en) | 2017-03-07 | 2024-07-09 | 4C Medical Technologies, Inc. | Systems, methods and devices for prosthetic heart valve with single valve leaflet |
| US10433961B2 (en) | 2017-04-18 | 2019-10-08 | Twelve, Inc. | Delivery systems with tethers for prosthetic heart valve devices and associated methods |
| US10702378B2 (en) | 2017-04-18 | 2020-07-07 | Twelve, Inc. | Prosthetic heart valve device and associated systems and methods |
| US10575950B2 (en) | 2017-04-18 | 2020-03-03 | Twelve, Inc. | Hydraulic systems for delivering prosthetic heart valve devices and associated methods |
| US10792151B2 (en) | 2017-05-11 | 2020-10-06 | Twelve, Inc. | Delivery systems for delivering prosthetic heart valve devices and associated methods |
| US10646338B2 (en) | 2017-06-02 | 2020-05-12 | Twelve, Inc. | Delivery systems with telescoping capsules for deploying prosthetic heart valve devices and associated methods |
| US10709591B2 (en) | 2017-06-06 | 2020-07-14 | Twelve, Inc. | Crimping device and method for loading stents and prosthetic heart valves |
| US12036113B2 (en) | 2017-06-14 | 2024-07-16 | 4C Medical Technologies, Inc. | Delivery of heart chamber prosthetic valve implant |
| US10786352B2 (en) | 2017-07-06 | 2020-09-29 | Twelve, Inc. | Prosthetic heart valve devices and associated systems and methods |
| US10729541B2 (en) | 2017-07-06 | 2020-08-04 | Twelve, Inc. | Prosthetic heart valve devices and associated systems and methods |
| US11382751B2 (en) * | 2017-10-24 | 2022-07-12 | St. Jude Medical, Cardiology Division, Inc. | Self-expandable filler for mitigating paravalvular leak |
| WO2020223669A1 (en) * | 2019-05-02 | 2020-11-05 | University Of Maryland, Baltimore | Valve translocation device and method for the treatment of functional valve regurgitation |
| US11857441B2 (en) | 2018-09-04 | 2024-01-02 | 4C Medical Technologies, Inc. | Stent loading device |
| WO2020115188A1 (en) * | 2018-12-05 | 2020-06-11 | Xeltis Ag | Electrospun suture ring |
| US11452628B2 (en) | 2019-04-15 | 2022-09-27 | 4C Medical Technologies, Inc. | Loading systems for collapsible prosthetic heart valve devices and methods thereof |
| CN112190365A (zh) * | 2019-07-08 | 2021-01-08 | 上海微创心通医疗科技有限公司 | 一种人工心脏瓣叶及心脏瓣膜假体 |
| US12133797B2 (en) | 2020-01-31 | 2024-11-05 | 4C Medical Technologies, Inc. | Prosthetic heart valve delivery system: paddle attachment feature |
| US11931253B2 (en) | 2020-01-31 | 2024-03-19 | 4C Medical Technologies, Inc. | Prosthetic heart valve delivery system: ball-slide attachment |
| US12053375B2 (en) | 2020-03-05 | 2024-08-06 | 4C Medical Technologies, Inc. | Prosthetic mitral valve with improved atrial and/or annular apposition and paravalvular leakage mitigation |
| US11992403B2 (en) | 2020-03-06 | 2024-05-28 | 4C Medical Technologies, Inc. | Devices, systems and methods for improving recapture of prosthetic heart valve device with stent frame having valve support with inwardly stent cells |
Family Cites Families (171)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2127903A (en) | 1936-05-05 | 1938-08-23 | Davis & Geck Inc | Tube for surgical purposes and method of preparing and using the same |
| US2900644A (en) | 1955-11-01 | 1959-08-25 | Johnson & Johnson | Heterograft material |
| AT261800B (de) | 1966-08-22 | 1968-05-10 | Braun Internat Gmbh B | Verfahren zur Herstellung von röhrenförmigen, glatten bzw. mit einem Gewinde versehenen Gewebe-Blutgefäß-Prothesen |
| JPS5230097A (en) | 1975-09-02 | 1977-03-07 | Kaneyasu Miyata | Method of mounting different substitute blood vessel |
| US4466139A (en) | 1980-07-01 | 1984-08-21 | Vettivetpillai Ketharanathan | Vascular prostheses |
| US4535483A (en) | 1983-01-17 | 1985-08-20 | Hemex, Inc. | Suture rings for heart valves |
| US4801299A (en) | 1983-06-10 | 1989-01-31 | University Patents, Inc. | Body implants of extracellular matrix and means and methods of making and using such implants |
| US4798611A (en) | 1986-10-14 | 1989-01-17 | Hancock Jaffe Laboratories | Enhancement of xenogeneic tissue |
| US4902508A (en) | 1988-07-11 | 1990-02-20 | Purdue Research Foundation | Tissue graft composition |
| US4956178A (en) | 1988-07-11 | 1990-09-11 | Purdue Research Foundation | Tissue graft composition |
| DE4125400C2 (de) | 1991-07-31 | 2000-08-17 | Edwin Klaus | Verwendung von unlöslichem Kollagen zur Behandlung von degenerativen, nicht entzündlichen Gelenkprozessen |
| US5281422A (en) | 1991-09-24 | 1994-01-25 | Purdue Research Foundation | Graft for promoting autogenous tissue growth |
| EP0629135B1 (en) | 1992-03-02 | 2000-07-26 | Bioeng, Inc. | Viral inactivation method |
| US5352463A (en) | 1992-11-13 | 1994-10-04 | Badylak Steven F | Tissue graft for surgical reconstruction of a collagenous meniscus and method therefor |
| US5641518A (en) | 1992-11-13 | 1997-06-24 | Purdue Research Foundation | Method of repairing bone tissue |
| US5275826A (en) | 1992-11-13 | 1994-01-04 | Purdue Research Foundation | Fluidized intestinal submucosa and its use as an injectable tissue graft |
| US6653291B1 (en) | 1992-11-13 | 2003-11-25 | Purdue Research Foundation | Composition and method for production of transformed cells |
| US5713950A (en) | 1993-11-01 | 1998-02-03 | Cox; James L. | Method of replacing heart valves using flexible tubes |
| US5480424A (en) | 1993-11-01 | 1996-01-02 | Cox; James L. | Heart valve replacement using flexible tubes |
| US5460962A (en) | 1994-01-04 | 1995-10-24 | Organogenesis Inc. | Peracetic acid sterilization of collagen or collagenous tissue |
| US6334872B1 (en) | 1994-02-18 | 2002-01-01 | Organogenesis Inc. | Method for treating diseased or damaged organs |
| EP0871414B1 (en) | 1994-03-14 | 2004-04-28 | Cryolife, Inc | Preparation methods of tissue for implantation |
| CA2188563C (en) | 1994-04-29 | 2005-08-02 | Andrew W. Buirge | Stent with collagen |
| US6475232B1 (en) | 1996-12-10 | 2002-11-05 | Purdue Research Foundation | Stent with reduced thrombogenicity |
| US6485723B1 (en) | 1995-02-10 | 2002-11-26 | Purdue Research Foundation | Enhanced submucosal tissue graft constructs |
| US5695998A (en) | 1995-02-10 | 1997-12-09 | Purdue Research Foundation | Submucosa as a growth substrate for islet cells |
| US5711969A (en) | 1995-04-07 | 1998-01-27 | Purdue Research Foundation | Large area submucosal tissue graft constructs |
| US20020095218A1 (en) | 1996-03-12 | 2002-07-18 | Carr Robert M. | Tissue repair fabric |
| US5554389A (en) | 1995-04-07 | 1996-09-10 | Purdue Research Foundation | Urinary bladder submucosa derived tissue graft |
| EP0820301B1 (en) | 1995-04-07 | 2002-07-24 | Purdue Research Foundation | Tissue graft for urinary bladder reconstruction |
| US7611533B2 (en) | 1995-06-07 | 2009-11-03 | Cook Incorporated | Coated implantable medical device |
| US6774278B1 (en) | 1995-06-07 | 2004-08-10 | Cook Incorporated | Coated implantable medical device |
| US5609629A (en) | 1995-06-07 | 1997-03-11 | Med Institute, Inc. | Coated implantable medical device |
| CA2178541C (en) | 1995-06-07 | 2009-11-24 | Neal E. Fearnot | Implantable medical device |
| US5900433A (en) | 1995-06-23 | 1999-05-04 | Cormedics Corp. | Vascular treatment method and apparatus |
| US5755791A (en) | 1996-04-05 | 1998-05-26 | Purdue Research Foundation | Perforated submucosal tissue graft constructs |
| US6666892B2 (en) | 1996-08-23 | 2003-12-23 | Cook Biotech Incorporated | Multi-formed collagenous biomaterial medical device |
| US8716227B2 (en) | 1996-08-23 | 2014-05-06 | Cook Biotech Incorporated | Graft prosthesis, materials and methods |
| SK22499A3 (en) | 1996-08-23 | 1999-10-08 | Cook Biotech Inc | Graft prosthesis, materials and methods |
| ES2213835T3 (es) | 1996-09-16 | 2004-09-01 | Purdue Research Foundation | Injerto de tejidos intestinales submucosales para la reparacion de tejidos neurologicos. |
| AU722065B2 (en) | 1996-11-05 | 2000-07-20 | Purdue Research Foundation | Myocardial graft constructs |
| US6375989B1 (en) | 1996-12-10 | 2002-04-23 | Purdue Research Foundation | Submucosa extracts |
| WO1998025546A1 (en) | 1996-12-10 | 1998-06-18 | Cook Biotech, Inc. | Tubular grafts from purified submucosa |
| WO1998025637A1 (en) | 1996-12-10 | 1998-06-18 | Purdue Research Foundation | Biomaterial derived from vertebrate liver tissue |
| DE69720252T2 (de) | 1996-12-10 | 2003-12-04 | Purdue Research Foundation, West Lafayette | Gewebetransplantat aus der magensubmukosa |
| CA2272097C (en) | 1996-12-10 | 2007-02-20 | Purdue Research Foundation | Artificial vascular valves |
| US6696270B2 (en) | 1996-12-10 | 2004-02-24 | Purdue Research Foundation | Gastric submucosal tissue as a novel diagnostic tool |
| US5993844A (en) | 1997-05-08 | 1999-11-30 | Organogenesis, Inc. | Chemical treatment, without detergents or enzymes, of tissue to form an acellular, collagenous matrix |
| EP1011699B1 (en) | 1997-09-11 | 2001-12-05 | Purdue Research Foundation | Galactosidase modified submucosal tissue |
| US6045576A (en) | 1997-09-16 | 2000-04-04 | Baxter International Inc. | Sewing ring having increased annular coaptation |
| US6264992B1 (en) | 1998-02-27 | 2001-07-24 | Purdue Research Foundation | Submucosa as a growth substrate for cells |
| US7452371B2 (en) | 1999-06-02 | 2008-11-18 | Cook Incorporated | Implantable vascular device |
| ES2323099T3 (es) | 1998-06-05 | 2009-07-06 | Organogenesis Inc. | Protesis de injerto tubulares producidas por bioingenieria. |
| ATE424164T1 (de) | 1998-06-05 | 2009-03-15 | Organogenesis Inc | Verfahren zur herstellung einer gefässprothese |
| CA2334228C (en) | 1998-06-05 | 2010-09-28 | Organogenesis Inc. | Bioengineered vascular graft support prostheses |
| US6933326B1 (en) | 1998-06-19 | 2005-08-23 | Lifecell Coporation | Particulate acellular tissue matrix |
| US6254636B1 (en) * | 1998-06-26 | 2001-07-03 | St. Jude Medical, Inc. | Single suture biological tissue aortic stentless valve |
| US6299604B1 (en) | 1998-08-20 | 2001-10-09 | Cook Incorporated | Coated implantable medical device |
| US8882850B2 (en) | 1998-12-01 | 2014-11-11 | Cook Biotech Incorporated | Multi-formed collagenous biomaterial medical device |
| AU4316399A (en) | 1998-12-01 | 2000-06-19 | Cook Biotech, Inc. | A multi-formed collagenous biomaterial medical device |
| US6918396B1 (en) | 1998-12-01 | 2005-07-19 | Purdue Research Foundation | Method for vocal cord reconstruction |
| DK1051116T3 (da) | 1998-12-01 | 2009-02-02 | Univ Washington | Emboliseringsanordning |
| EP1146835B1 (en) | 1999-01-26 | 2008-11-19 | Edwards Lifesciences Corporation | Anatomical orifice sizers |
| US20030096740A1 (en) | 1999-03-10 | 2003-05-22 | Lars Hammarstrom | Matrix protein compositions for induction of apoptosis |
| US7628803B2 (en) | 2001-02-05 | 2009-12-08 | Cook Incorporated | Implantable vascular device |
| EP1207819B1 (en) | 1999-08-06 | 2009-03-04 | Cook Biotech, Inc. | Tubular graft construct |
| US6579538B1 (en) | 1999-12-22 | 2003-06-17 | Acell, Inc. | Tissue regenerative compositions for cardiac applications, method of making, and method of use thereof |
| US20040043006A1 (en) | 2002-08-27 | 2004-03-04 | Badylak Stephen F. | Tissue regenerative composition |
| EP1255510B3 (en) | 2000-01-31 | 2009-03-04 | Cook Biotech, Inc. | Stent valves |
| US7033611B2 (en) | 2001-02-23 | 2006-04-25 | Biora Bioex Ab | Matrix protein compositions for guided connective tissue growth |
| US6733525B2 (en) * | 2001-03-23 | 2004-05-11 | Edwards Lifesciences Corporation | Rolled minimally-invasive heart valves and methods of use |
| DE60104647T2 (de) | 2001-03-27 | 2005-08-11 | William Cook Europe Aps | Gefässtransplantat für die Aorta |
| US20020147496A1 (en) | 2001-04-06 | 2002-10-10 | Integrated Vascular Systems, Inc. | Apparatus for treating spinal discs |
| WO2002089711A1 (en) | 2001-05-07 | 2002-11-14 | Crosscart, Inc. | Submucosal xenografts |
| EP1404388B1 (en) | 2001-06-28 | 2013-10-23 | Cook Biotech, Inc. | Graft prosthesis devices containing renal capsule collagen |
| US8092529B2 (en) | 2001-07-16 | 2012-01-10 | Depuy Products, Inc. | Meniscus regeneration device |
| US6706069B2 (en) | 2001-09-13 | 2004-03-16 | J. Lee Berger | Spinal grooved director with built in balloon |
| US6726715B2 (en) | 2001-10-23 | 2004-04-27 | Childrens Medical Center Corporation | Fiber-reinforced heart valve prosthesis |
| DK1438081T3 (da) | 2001-10-26 | 2008-07-07 | Cook Biotech Inc | Medicinsk transplantatanordning med mesh mönstret struktur |
| CA2466270C (en) | 2001-11-29 | 2010-09-14 | Cook Incorporated | Medical device delivery system |
| NZ536563A (en) | 2002-05-02 | 2008-03-28 | Purdue Research Foundation | Vascularization enhanced graft constructs |
| EP1585426A4 (en) | 2002-05-02 | 2006-09-20 | Cook Biotech Inc | WITH CELLS VACCINATED EXTRACELLULAR MATRIX TRANSPLANTS |
| CA2483913C (en) | 2002-05-02 | 2014-07-15 | Purdue Research Foundation | Vascularization enhanced graft constructs comprising basement membrane |
| CA2483908C (en) | 2002-05-02 | 2012-02-21 | Purdue Research Foundation | Vascularization enhanced graft constructs |
| WO2003092554A1 (en) | 2002-05-03 | 2003-11-13 | The General Hospital Corporation | Involuted endovascular valve and method of construction |
| AU2003265477B2 (en) * | 2002-08-15 | 2009-08-13 | Cook Medical Technologies Llc | Stent and method of forming a stent with integral barbs |
| US7550004B2 (en) | 2002-08-20 | 2009-06-23 | Cook Biotech Incorporated | Endoluminal device with extracellular matrix material and methods |
| WO2004022107A2 (en) | 2002-09-06 | 2004-03-18 | Cook Biotech Incorporated | Tissue graft prosthesis devices containing juvenile or small diameter submucosa |
| US7087034B2 (en) | 2002-09-19 | 2006-08-08 | Mcpherson William E | Vascular shunt with audio flow indication |
| US7189259B2 (en) | 2002-11-26 | 2007-03-13 | Clemson University | Tissue material and process for bioprosthesis |
| US20040191226A1 (en) | 2002-12-04 | 2004-09-30 | Badylak Stephen F. | Method for repair of body wall |
| US20040187877A1 (en) | 2002-12-04 | 2004-09-30 | Badylak Stephen F. | Method for repair of liver tissue |
| ATE452601T1 (de) | 2003-03-12 | 2010-01-15 | Cook Inc | Herzklappenprothese, welche rückfluss zulässt |
| US7530995B2 (en) * | 2003-04-17 | 2009-05-12 | 3F Therapeutics, Inc. | Device for reduction of pressure effects of cardiac tricuspid valve regurgitation |
| ATE446061T1 (de) | 2003-04-24 | 2009-11-15 | Cook Inc | Künstliche klappe für blutgefäss mit verbessertem fliessverhalten |
| AU2003902037A0 (en) | 2003-04-24 | 2003-05-15 | Mclachlan, Craig | Method for tissue growth |
| ATE481057T1 (de) | 2003-05-28 | 2010-10-15 | Cook Inc | Ventilprothese mit gefässbefestigungsvorrichtung |
| US7108832B2 (en) | 2003-06-23 | 2006-09-19 | Novasterilis Inc. | Sterialization methods and apparatus which employ additive-containing supercritical carbon dioxide sterilant |
| WO2005002601A1 (en) | 2003-06-25 | 2005-01-13 | Badylak Stephen F | Conditioned matrix compositions for tissue restoration |
| US20050013870A1 (en) | 2003-07-17 | 2005-01-20 | Toby Freyman | Decellularized extracellular matrix of conditioned body tissues and uses thereof |
| WO2005011535A2 (en) | 2003-07-31 | 2005-02-10 | Cook Incorporated | Prosthetic valve for implantation in a body vessel |
| EP1659992B1 (en) | 2003-07-31 | 2013-03-27 | Cook Medical Technologies LLC | Prosthetic valve devices and methods of making such devices |
| WO2005020847A2 (en) | 2003-08-25 | 2005-03-10 | Cook Biotech Incorporated | Graft materials containing bioactive substances, and methods for their manufacture |
| US8741352B2 (en) | 2003-08-25 | 2014-06-03 | Cook Biotech Incorporated | Graft materials containing ECM components, and methods for their manufacture |
| DE10340265A1 (de) | 2003-08-29 | 2005-04-07 | Sievers, Hans-Hinrich, Prof. Dr.med. | Prothese zum Ersatz der Aorten- und/oder Mitralklappe des Herzens |
| GB2423934B (en) | 2003-09-04 | 2007-11-28 | Cook Biotech Inc | Extracellular matrix composite materials, and manufacture and use thereof |
| US7763459B2 (en) | 2003-10-02 | 2010-07-27 | Depuy Spine, Inc. | Chemical treatment for removing cellular and nuclear material from naturally occurring extracellular matrix-based biomaterials |
| JP2007520259A (ja) | 2003-11-10 | 2007-07-26 | シンフォニー メディカル, インコーポレイテッド | 心房細動患者における心室速度を制御するための方法 |
| WO2005077433A1 (en) | 2004-02-09 | 2005-08-25 | Cook Biotech Incorporated | Stent graft devices having collagen coating |
| GB2451785B (en) | 2004-03-29 | 2009-03-25 | Cook Biotech Inc | Medical graft products with differing regions |
| JP2007532153A (ja) | 2004-03-31 | 2007-11-15 | クック インコーポレイテッド | Ecmを基材としたグラフト材料 |
| DE602005020754D1 (de) | 2004-03-31 | 2010-06-02 | Cook Inc | Transplantatmaterial und gefässprothese mit extrazellulärer kollagenmatrix und dessen herstellungsverfahren |
| AU2005231356A1 (en) | 2004-03-31 | 2005-10-20 | Med Institute, Inc. | Endoluminal graft with a prosthetic valve |
| EP2425801A3 (en) * | 2004-05-05 | 2013-01-02 | Direct Flow Medical, Inc. | Unstented heart valve with formed in place support structure |
| EP1771216B1 (en) | 2004-07-30 | 2017-07-12 | Cook Biotech, Inc. | Graft with increased resistance to enzymatic degradation |
| EP1807023A1 (en) | 2004-09-10 | 2007-07-18 | Cook Incorporated | Prosthetic valve with pores |
| UA88321C2 (ru) | 2004-09-30 | 2009-10-12 | Ковалон Текнолоджиз Инк. | Неадгезивные эластичные желатиновые матрицы |
| AU2005294316A1 (en) | 2004-10-06 | 2006-04-20 | Cook Incorporated | Medical device with bioactive agent |
| WO2006044512A1 (en) | 2004-10-15 | 2006-04-27 | Cook Biotech Incorporated | Fibronectin-modified ecm tissue graft constructs and methods for preparation and use thereof |
| WO2006050459A2 (en) | 2004-10-28 | 2006-05-11 | Cook Incorporated | Methods and systems for modifying vascular valves |
| US7563276B2 (en) | 2004-10-29 | 2009-07-21 | Cook Incorporated | Intraluminal medical device with cannula for controlled retrograde flow |
| US9138445B2 (en) | 2005-03-09 | 2015-09-22 | Cook Biotech Incorporated | Medical graft materials with adherent extracellular matrix fibrous mass |
| WO2006102063A2 (en) | 2005-03-19 | 2006-09-28 | Cook Biotech Incorporated | Prosthetic implants including ecm composite material |
| ATE454862T1 (de) | 2005-03-24 | 2010-01-15 | Cook Inc | Austauschbares abgabesystem mit distalem schutz |
| US7579381B2 (en) | 2005-03-25 | 2009-08-25 | Edwards Lifesciences Corporation | Treatment of bioprosthetic tissues to mitigate post implantation calcification |
| US8197534B2 (en) | 2005-03-31 | 2012-06-12 | Cook Medical Technologies Llc | Valve device with inflatable chamber |
| US20060259128A1 (en) | 2005-04-18 | 2006-11-16 | Cook Incorporated | Method for implanting prosthetic valves |
| CA2607913C (en) | 2005-05-05 | 2014-03-18 | Cook Biotech Incorporated | Implantable materials and methods for inhibiting tissue adhesion formation |
| AU2006247317B2 (en) | 2005-05-16 | 2012-04-05 | Purdue Research Foundation | Engineered extracellular matrices |
| US20100080790A1 (en) | 2005-07-13 | 2010-04-01 | University Of South Carolina | Sterilization using high-pressure carbon dioxide |
| US20070014869A1 (en) | 2005-07-15 | 2007-01-18 | Cormatrix Cardiovascular, Inc. | Compositions for reconstruction, replacement or repair of intracardiac tissue |
| US20070014868A1 (en) | 2005-07-15 | 2007-01-18 | Cormatrix Cardiovascular, Inc. | Patch for reconstruction, replacement or repair of the pericardial sac |
| US20080279939A1 (en) | 2007-05-10 | 2008-11-13 | Firestone Leigh H | Extracellular matrix compositions for tissue regeneration |
| US8568761B2 (en) | 2005-07-15 | 2013-10-29 | Cormatrix Cardiovascular, Inc. | Compositions for regenerating defective or absent myocardium |
| AU2006292203A1 (en) | 2005-09-21 | 2007-03-29 | Dask Technologies, Llc | Methods and compositions for organ and tissue functionality |
| US7815923B2 (en) | 2005-12-29 | 2010-10-19 | Cook Biotech Incorporated | Implantable graft material |
| US20070166396A1 (en) | 2006-01-06 | 2007-07-19 | University Of Pittsburgh | Extracellular matrix based gastroesophageal junction reinforcement device |
| US9532943B2 (en) | 2010-12-20 | 2017-01-03 | Cormatrix Cardiovascular, Inc. | Drug eluting patch for the treatment of localized tissue disease or defect |
| US20080046070A1 (en) | 2006-03-31 | 2008-02-21 | Obermiller F J | Chemically treated extracellular matrices for affecting the cellular response |
| US20070269476A1 (en) | 2006-05-16 | 2007-11-22 | Voytik-Harbin Sherry L | Engineered extracellular matrices control stem cell behavior |
| CA2653913C (en) | 2006-05-30 | 2012-04-17 | Cook Incorporated | Artificial valve prosthesis |
| US20080097601A1 (en) | 2006-07-31 | 2008-04-24 | Jeanne Codori-Hurff | Mastopexy and Breast Reconstruction Prostheses and Method |
| CN106390200A (zh) | 2006-10-23 | 2017-02-15 | 库克生物科技公司 | 组分特性增强的处理的ecm材料 |
| ATE515244T1 (de) | 2007-02-15 | 2011-07-15 | Cook Inc | Künstliche klappenprothese mit freiem blattabschnitt |
| EP2025306B1 (en) | 2007-04-23 | 2020-01-01 | Saint Joseph Research Institute | Methods of making a replacement heart valve |
| EP2150283B1 (en) | 2007-04-27 | 2011-10-12 | Cook Biotech Incorporated | Growth factor modified extracellular matrix material and methods for preparation and use thereof |
| US9034367B2 (en) | 2007-05-10 | 2015-05-19 | Cormatrix Cardiovascular, Inc. | Articles for tissue regeneration with biodegradable polymer |
| US20080281419A1 (en) | 2007-05-10 | 2008-11-13 | Matheny Robert G | Breast implants and compositions of extracellular matrix |
| US20080279833A1 (en) | 2007-05-10 | 2008-11-13 | Matheny Robert G | Laminate sheet articles for tissue regeneration |
| US8403979B2 (en) | 2007-05-17 | 2013-03-26 | Cook Medical Technologies Llc | Monocuspid prosthetic valve having a partial sinus |
| US20090142400A1 (en) | 2007-05-31 | 2009-06-04 | Hiles Michael C | Analgesic coated medical product |
| US8715337B2 (en) | 2007-11-09 | 2014-05-06 | Cook Medical Technologies Llc | Aortic valve stent graft |
| US8313526B2 (en) | 2007-11-19 | 2012-11-20 | Cook Medical Technologies Llc | Valve frame |
| WO2009076391A2 (en) | 2007-12-10 | 2009-06-18 | Cook Biotech Incorporated | Medical materials including modified extracellular matrix materials |
| US20090157177A1 (en) | 2007-12-18 | 2009-06-18 | Matheny Robert G | Sewing Ring for a Prosthetic Tissue Valve |
| US20090157170A1 (en) | 2007-12-18 | 2009-06-18 | Matheny Robert G | Trileaflet Semi-Lunar Prosthetic Tissue Valve |
| US8257434B2 (en) | 2007-12-18 | 2012-09-04 | Cormatrix Cardiovascular, Inc. | Prosthetic tissue valve |
| US7854759B2 (en) | 2007-12-21 | 2010-12-21 | Cook Incorporated | Prosthetic flow modifying device |
| WO2009114052A2 (en) | 2008-03-14 | 2009-09-17 | Cook Biotech Incorporated | Graft materials and methods for staged delivery of bioactive components |
| ATE556679T1 (de) | 2008-04-09 | 2012-05-15 | Cook Medical Technologies Llc | Ladegerät und verfahren für expandierbare intraluminale medizinische vorrichtungen |
| US7771652B2 (en) | 2008-04-11 | 2010-08-10 | Novasterilis, Inc. | Combined use of an alkaline earth metal compound and a sterilizing agent to maintain osteoinduction properties of a demineralized bone matrix |
| US8323337B2 (en) | 2008-06-05 | 2012-12-04 | Medtronic, Inc. | Connection systems for two piece prosthetic heart valve assemblies and methods for making and using them |
| WO2010011878A2 (en) | 2008-07-24 | 2010-01-28 | Cook Incorporated | Valve device with biased leaflets |
| CN102256609B (zh) | 2008-07-30 | 2014-02-19 | 米辛瑟斯有限公司 | 衍生自前胃胞外基质的组织支架 |
| EP4218675A3 (en) * | 2008-09-19 | 2023-08-30 | Edwards Lifesciences Corporation | Prosthetic heart valve configured to receive a percutaneous prosthetic heart valve implantation |
| WO2010078620A1 (en) | 2009-01-07 | 2010-07-15 | Martin Kean Chong Ng | Chemically and biologically modified medical devices |
| AU2010216095B2 (en) | 2009-02-18 | 2015-10-08 | Cormatrix Cardiovascular, Inc. | Compositions and methods for preventing cardiac arrhythmia |
| US20100239632A1 (en) | 2009-03-23 | 2010-09-23 | Warsaw Orthopedic, Inc. | Drug depots for treatment of pain and inflammation in sinus and nasal cavities or cardiac tissue |
| WO2011031299A1 (en) | 2009-08-28 | 2011-03-17 | Mount Sinai School Of Medicine Of New York University | Intrapericardial injections |
| EP2714099A4 (en) | 2011-05-27 | 2014-11-19 | Cormatrix Cardiovascular Inc | STERILIZED, ACELLULAR EXTRACELLULAR MATRIX COMPOSITIONS AND METHODS OF MAKING SAME |
| SG194881A1 (en) | 2011-05-31 | 2013-12-30 | Cormatrix Cardiovascular Inc | Compositions for preventing cardiac arrhythmia |
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2010
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- 2011-08-31 KR KR1020137005555A patent/KR20140010929A/ko not_active Withdrawn
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- 2012-07-26 US US13/559,412 patent/US8449607B2/en active Active
- 2012-07-27 US US13/560,573 patent/US8409275B2/en active Active
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- 2013-03-13 US US13/801,242 patent/US8608796B2/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20220117089A (ko) | 2021-02-16 | 2022-08-23 | 재단법인 아산사회복지재단 | 인조혈관 복합물 |
| WO2022177272A1 (ko) | 2021-02-16 | 2022-08-25 | 재단법인 아산사회복지재단 | 인조혈관 복합물 |
| KR20220126495A (ko) | 2021-03-09 | 2022-09-16 | 재단법인 아산사회복지재단 | 인조혈관 크기 책정기 및 그 측정방법 |
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| US20110066237A1 (en) | 2011-03-17 |
| US20120290081A1 (en) | 2012-11-15 |
| US20130204358A1 (en) | 2013-08-08 |
| JP2013539392A (ja) | 2013-10-24 |
| EP2611390A4 (en) | 2014-12-24 |
| CA2810008A1 (en) | 2012-03-08 |
| WO2012030996A1 (en) | 2012-03-08 |
| BR112013005180A2 (pt) | 2016-04-26 |
| US8409275B2 (en) | 2013-04-02 |
| US20120290080A1 (en) | 2012-11-15 |
| AU2011295982A1 (en) | 2013-03-07 |
| US8608796B2 (en) | 2013-12-17 |
| SG187985A1 (en) | 2013-03-28 |
| AU2011295982B2 (en) | 2015-04-09 |
| US8257434B2 (en) | 2012-09-04 |
| US8449607B2 (en) | 2013-05-28 |
| EP2611390A1 (en) | 2013-07-10 |
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