KR20130132903A - 항-ccr4 항체들 및 이의 용도들 - Google Patents
항-ccr4 항체들 및 이의 용도들 Download PDFInfo
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- KR20130132903A KR20130132903A KR20137017710A KR20137017710A KR20130132903A KR 20130132903 A KR20130132903 A KR 20130132903A KR 20137017710 A KR20137017710 A KR 20137017710A KR 20137017710 A KR20137017710 A KR 20137017710A KR 20130132903 A KR20130132903 A KR 20130132903A
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- Prior art keywords
- ccr4
- antibody
- antibodies
- cells
- seq
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- G—PHYSICS
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
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- Immunology (AREA)
- Oncology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
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- Biochemistry (AREA)
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- Biomedical Technology (AREA)
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- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Reproductive Health (AREA)
- Cardiology (AREA)
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- Pain & Pain Management (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42037010P | 2010-12-07 | 2010-12-07 | |
| GB201020738A GB201020738D0 (en) | 2010-12-07 | 2010-12-07 | Antibodies |
| GB1020738.9 | 2010-12-07 | ||
| US61/420,370 | 2010-12-07 | ||
| PCT/GB2011/052421 WO2012076883A1 (en) | 2010-12-07 | 2011-12-07 | Anti ccr4 antibodies and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20130132903A true KR20130132903A (ko) | 2013-12-05 |
Family
ID=43531609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR20137017710A Withdrawn KR20130132903A (ko) | 2010-12-07 | 2011-12-07 | 항-ccr4 항체들 및 이의 용도들 |
Country Status (17)
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2512857A (en) | 2013-04-09 | 2014-10-15 | Cancer Res Technology | Cancer biomarker |
| WO2015191997A1 (en) * | 2014-06-12 | 2015-12-17 | The General Hospital Corporation | Anti-human chemokine (c-c motif) receptor 4 immunotoxins |
| DK3160513T3 (da) | 2014-06-30 | 2020-04-06 | Glykos Finland Oy | Saccharidderivat af en toksisk payload og antistofkonjugater deraf |
| AU2015328273B2 (en) * | 2014-10-06 | 2020-09-17 | Dana-Farber Cancer Institute, Inc. | Humanized CC chemokine receptor 4 (CCR4) antibodies and methods of use thereof |
| CN108135976B (zh) | 2015-07-23 | 2022-10-18 | 博灵格英格尔海姆国际股份公司 | 靶向il-23a和b细胞激活因子(baff)的化合物和其用途 |
| RU2769282C2 (ru) | 2016-06-20 | 2022-03-30 | Кимаб Лимитед | Анти-PD-L1 и IL-2 цитокины |
| CA3088484A1 (en) * | 2017-01-30 | 2018-08-02 | Ofer Nussbaum | Chemical entities suitable for therapy |
| JP6811480B2 (ja) * | 2017-02-28 | 2021-01-13 | 日本全薬工業株式会社 | イヌ皮膚t細胞リンパ腫細胞株 |
| US20210163607A1 (en) | 2017-05-19 | 2021-06-03 | Nippon Zenyaku Kogyo Co., Ltd. | Method for suppressing regulatory t cell infiltration by ccr4 inhibition and method for treating canine neoplastic disease |
| KR20250056192A (ko) | 2017-08-07 | 2025-04-25 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 안전한 세포 치료제를 생성하기 위한 플랫폼 |
| CN108250290B (zh) * | 2018-02-23 | 2024-03-12 | 上海捌加壹医药科技有限公司 | Ccr4的n端重组蛋白及其用途 |
| EP3976640A1 (en) * | 2019-05-24 | 2022-04-06 | City of Hope | Ccr4 targeted chimeric antigen receptor modified t cells for treatment of ccr4 positive malignancies |
| CN111135310B (zh) * | 2019-12-24 | 2021-05-07 | 江苏省人民医院(南京医科大学第一附属医院) | 一种定制化t细胞表位疫苗的双靶向纳米药、其制备方法及应用 |
| JP6960642B2 (ja) * | 2020-04-16 | 2021-11-05 | 国立研究開発法人国立国際医療研究センター | 呼吸器感染症の重症化の予測を補助する方法、バイオマーカーの測定値をモニタリングする方法、これらの方法に用いられる試薬キット、呼吸器感染症の重症化の予測を補助する装置およびコンピュータプログラム |
| CN111704668B (zh) * | 2020-06-27 | 2021-03-30 | 天津金域医学检验实验室有限公司 | 抗ccr4抗体及其在治疗癌症中的应用 |
| CN117187180B (zh) * | 2023-11-03 | 2024-01-26 | 四川大学 | 一种Th17细胞及其培养方法和应用及其诱导液 |
| WO2025145207A1 (en) | 2023-12-29 | 2025-07-03 | Bristol-Myers Squibb Company | Combination therapy of kras inhibitor and treg-depleting agent |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2437213A1 (fr) | 1978-09-28 | 1980-04-25 | Cm Ind | Produits cytotoxiques formes par liaison covalente de la chaine a de la ricine avec un anticorps et leur procede de preparation |
| US4736866B1 (en) | 1984-06-22 | 1988-04-12 | Transgenic non-human mammals | |
| WO1990010457A1 (en) | 1989-03-14 | 1990-09-20 | New York University | Method of treating hiv infections using immunotoxins |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| AU3178993A (en) | 1991-11-25 | 1993-06-28 | Enzon, Inc. | Multivalent antigen-binding proteins |
| WO1993017715A1 (en) | 1992-03-05 | 1993-09-16 | Board Of Regents, The University Of Texas System | Diagnostic and/or therapeutic agents, targeted to neovascular endothelial cells |
| US5660827A (en) | 1992-03-05 | 1997-08-26 | Board Of Regents, The University Of Texas System | Antibodies that bind to endoglin |
| US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| US6488930B1 (en) | 1999-01-15 | 2002-12-03 | Millennium Pharmaceuticals, Inc. | Anti-CCR4 antibodies and methods of use therefor |
| AU2004201168A1 (en) | 1999-01-15 | 2004-04-22 | Millennium Pharmaceuticals, Inc. | Anti-CCR4 antibodies and methods of use therefor |
| US6245332B1 (en) * | 1999-01-15 | 2001-06-12 | The Board Of Trustees Of The Leland Stanford Junior University | Modulation of systemic memory T cell trafficking |
| EP1050307A1 (en) * | 1999-05-06 | 2000-11-08 | Applied Research Systems ARS Holding N.V. | CCR4 antagonists in sepsis |
| JP3926153B2 (ja) | 2000-03-03 | 2007-06-06 | 協和醗酵工業株式会社 | 遺伝子組換え抗体およびその抗体断片 |
| JP2004535157A (ja) | 2001-02-28 | 2004-11-25 | プロテイン デザイン ラブス, インコーポレイテッド | ケモカイン受容体と疾患 |
| MXPA04001894A (es) | 2001-08-31 | 2005-09-08 | Kyowa Hakko Kogyo Kk | Anticuerpo humano injertado en una cdr y fragmento de dicho anticuerpo. |
| WO2005035582A1 (ja) * | 2003-10-08 | 2005-04-21 | Kyowa Hakko Kogyo Co., Ltd. | Ccr4に特異的に結合する抗体組成物 |
| GB0718167D0 (en) | 2007-09-18 | 2007-10-31 | Cancer Rec Tech Ltd | Cancer marker and therapeutic target |
| WO2009086514A1 (en) * | 2007-12-28 | 2009-07-09 | Dana-Farber Cancer Institute, Inc. | Humanized monoclonal antibodies and methods of use |
| GB0909906D0 (en) * | 2009-06-09 | 2009-07-22 | Affitech As | Antibodies |
| US8802442B2 (en) | 2011-11-30 | 2014-08-12 | Eric B. Wheeldon | Apparatus and method for the remote sensing of blood in human feces and urine |
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2010
- 2010-12-07 GB GB201020738A patent/GB201020738D0/en not_active Ceased
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2011
- 2011-12-07 WO PCT/GB2011/052421 patent/WO2012076883A1/en not_active Ceased
- 2011-12-07 EA EA201390813A patent/EA201390813A1/ru unknown
- 2011-12-07 MX MX2013006167A patent/MX2013006167A/es not_active Application Discontinuation
- 2011-12-07 KR KR20137017710A patent/KR20130132903A/ko not_active Withdrawn
- 2011-12-07 SG SG2013037577A patent/SG190299A1/en unknown
- 2011-12-07 EP EP11794570.9A patent/EP2649097A1/en not_active Withdrawn
- 2011-12-07 JP JP2013542608A patent/JP6215707B2/ja not_active Expired - Fee Related
- 2011-12-07 CN CN201180066005.9A patent/CN103328513B/zh not_active Expired - Fee Related
- 2011-12-07 BR BR112013014235A patent/BR112013014235A2/pt not_active IP Right Cessation
- 2011-12-07 US US13/313,541 patent/US8895007B2/en not_active Expired - Fee Related
- 2011-12-07 NZ NZ612175A patent/NZ612175A/en not_active IP Right Cessation
- 2011-12-07 CA CA2818313A patent/CA2818313A1/en not_active Abandoned
- 2011-12-07 AU AU2011340264A patent/AU2011340264B2/en not_active Ceased
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2013
- 2013-05-19 IL IL226427A patent/IL226427A0/en unknown
- 2013-06-25 CO CO13150835A patent/CO6761356A2/es unknown
- 2013-06-25 ZA ZA2013/04723A patent/ZA201304723B/en unknown
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2014
- 2014-10-16 US US14/515,892 patent/US9458238B2/en not_active Expired - Fee Related
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| Publication number | Publication date |
|---|---|
| CN103328513B (zh) | 2016-04-27 |
| US9458238B2 (en) | 2016-10-04 |
| CO6761356A2 (es) | 2013-09-30 |
| AU2011340264B2 (en) | 2016-05-26 |
| JP6215707B2 (ja) | 2017-10-18 |
| IL226427A0 (en) | 2013-07-31 |
| GB201020738D0 (en) | 2011-01-19 |
| SG190299A1 (en) | 2013-06-28 |
| CN103328513A (zh) | 2013-09-25 |
| NZ612175A (en) | 2015-02-27 |
| BR112013014235A2 (pt) | 2016-09-27 |
| MX2013006167A (es) | 2013-09-06 |
| WO2012076883A1 (en) | 2012-06-14 |
| ZA201304723B (en) | 2014-02-26 |
| EP2649097A1 (en) | 2013-10-16 |
| EA201390813A1 (ru) | 2013-11-29 |
| US20120164161A1 (en) | 2012-06-28 |
| JP2014513519A (ja) | 2014-06-05 |
| US20150104831A1 (en) | 2015-04-16 |
| CA2818313A1 (en) | 2012-06-14 |
| US8895007B2 (en) | 2014-11-25 |
| AU2011340264A1 (en) | 2013-07-11 |
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