KR20130089271A - Tweak 및 fn14 활성을 조절하는 방법 및 조성물 - Google Patents

Tweak 및 fn14 활성을 조절하는 방법 및 조성물 Download PDF

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Publication number
KR20130089271A
KR20130089271A KR1020137015784A KR20137015784A KR20130089271A KR 20130089271 A KR20130089271 A KR 20130089271A KR 1020137015784 A KR1020137015784 A KR 1020137015784A KR 20137015784 A KR20137015784 A KR 20137015784A KR 20130089271 A KR20130089271 A KR 20130089271A
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tweak
antibody
receptor
cells
human
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Korean (ko)
Inventor
아비 제이. 아쉬케나지
헤더 매커
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제넨테크, 인크.
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Application filed by 제넨테크, 인크. filed Critical 제넨테크, 인크.
Publication of KR20130089271A publication Critical patent/KR20130089271A/ko
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Microbiology (AREA)
  • Transplantation (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020137015784A 2005-03-07 2006-03-02 Tweak 및 fn14 활성을 조절하는 방법 및 조성물 Withdrawn KR20130089271A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65933905P 2005-03-07 2005-03-07
US60/659,339 2005-03-07
PCT/US2006/007547 WO2006096487A2 (en) 2005-03-07 2006-03-02 Methods and compositions for modulating tweak and fn14 activity

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020077020346A Division KR20070108537A (ko) 2005-03-07 2006-03-02 Tweak 및 fn14 활성을 조절하는 방법 및 조성물

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR20157002807A Division KR20150031459A (ko) 2005-03-07 2006-03-02 Tweak 및 fn14 활성을 조절하는 방법 및 조성물

Publications (1)

Publication Number Publication Date
KR20130089271A true KR20130089271A (ko) 2013-08-09

Family

ID=36953868

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020137015784A Withdrawn KR20130089271A (ko) 2005-03-07 2006-03-02 Tweak 및 fn14 활성을 조절하는 방법 및 조성물
KR20157002807A Ceased KR20150031459A (ko) 2005-03-07 2006-03-02 Tweak 및 fn14 활성을 조절하는 방법 및 조성물
KR1020077020346A Withdrawn KR20070108537A (ko) 2005-03-07 2006-03-02 Tweak 및 fn14 활성을 조절하는 방법 및 조성물

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR20157002807A Ceased KR20150031459A (ko) 2005-03-07 2006-03-02 Tweak 및 fn14 활성을 조절하는 방법 및 조성물
KR1020077020346A Withdrawn KR20070108537A (ko) 2005-03-07 2006-03-02 Tweak 및 fn14 활성을 조절하는 방법 및 조성물

Country Status (12)

Country Link
US (2) US20080286271A1 (cg-RX-API-DMAC7.html)
EP (1) EP1853312B1 (cg-RX-API-DMAC7.html)
JP (2) JP2008531746A (cg-RX-API-DMAC7.html)
KR (3) KR20130089271A (cg-RX-API-DMAC7.html)
CN (2) CN101171035A (cg-RX-API-DMAC7.html)
AU (1) AU2006220825A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0608012A2 (cg-RX-API-DMAC7.html)
CA (1) CA2597485A1 (cg-RX-API-DMAC7.html)
IL (1) IL185180A0 (cg-RX-API-DMAC7.html)
RU (1) RU2007137060A (cg-RX-API-DMAC7.html)
WO (1) WO2006096487A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA200707489B (cg-RX-API-DMAC7.html)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0105044A3 (en) 1999-01-15 2004-07-28 Biogen Inc Cambridge Antagonists of tweak and of tweak receptor and their use to treat immunological disorders
US7208151B2 (en) 2001-09-12 2007-04-24 Biogen Idec Ma Inc. Tweak receptor agonists as anti-angiogenic agents
AU2003224950B2 (en) 2002-04-09 2006-09-14 Biogen Ma Inc. Methods for treating tweak-related conditions
DK2332408T3 (da) 2005-02-17 2013-12-02 Biogen Idec Inc Behandling af neurologiske sygdomme
WO2006088890A2 (en) * 2005-02-17 2006-08-24 Biogen Idec Ma Inc. Treating stroke
KR20130089271A (ko) * 2005-03-07 2013-08-09 제넨테크, 인크. Tweak 및 fn14 활성을 조절하는 방법 및 조성물
WO2006122187A2 (en) * 2005-05-10 2006-11-16 Biogen Idec Ma Inc. Treating and evaluating inflammatory disorders
WO2006130429A2 (en) * 2005-05-27 2006-12-07 Biogen Idec Ma Inc. Treatment of cancer
NZ583636A (en) 2005-05-27 2011-12-22 Biogen Idec Inc Tweak binding antibodies
WO2006138219A2 (en) 2005-06-13 2006-12-28 Biogen Idec Ma Inc. Methods of diagnosis / prognosis of inflammatory conditions
US20100284933A1 (en) * 2006-10-16 2010-11-11 Biogen Idec Ma Inc. Biomarkers of Multiple Sclerosis
MX2010001378A (es) * 2007-08-03 2010-06-02 Facet Biotech Corp Uso terapeutico de anticuerpos del receptor anti-tweak.
US8093006B2 (en) 2009-04-02 2012-01-10 Hoffmann-La Roche Inc. Antibodies against human tweak and uses thereof
US20120055055A1 (en) * 2010-09-02 2012-03-08 Illumin8 Outdoor Media, LLC Systems and Method for Outdoor Media Signage
WO2012045671A1 (en) * 2010-10-05 2012-04-12 F. Hoffmann-La Roche Ag Antibodies against human tweak and uses thereof
JP5832559B2 (ja) * 2011-03-10 2015-12-16 オメロス コーポレーション exvivoにおける加速された抗体進化による抗FN14モノクローナル抗体の生成
JP2016000003A (ja) * 2013-04-19 2016-01-07 アステラス製薬株式会社 新規抗ヒトtweak抗体
CN105779576B (zh) * 2014-12-25 2025-01-17 中国人民解放军第四军医大学 人tnfrsf12a基因的用途及其相关药物
US10994017B2 (en) 2016-12-02 2021-05-04 Avelas Biosciences, Inc. Nerve labeling compositions and uses thereof
MY204672A (en) 2018-10-31 2024-09-09 Astellas Pharma Inc Anti-human fn14 antibody

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998035061A2 (en) * 1997-02-12 1998-08-13 Abbott Laboratories Member of the tnf family useful for treatment and diagnosis of disease
HUP0105044A3 (en) * 1999-01-15 2004-07-28 Biogen Inc Cambridge Antagonists of tweak and of tweak receptor and their use to treat immunological disorders
EP1626058B1 (en) * 1999-03-08 2007-10-31 Genentech, Inc. Compositions and methods for the diagnosis of tumour
US7442776B2 (en) * 1999-10-08 2008-10-28 Young David S F Cancerous disease modifying antibodies
EP2298334A3 (en) * 1999-12-20 2012-04-04 Immunex Corporation Tweak receptor
US6727225B2 (en) 1999-12-20 2004-04-27 Immunex Corporation TWEAK receptor
CA2422095A1 (en) * 2000-09-14 2002-03-21 Biogen, Inc. Tweak receptor agonists as anti-angiogenic agents
AU2002220265A1 (en) * 2000-11-03 2002-05-15 University Of Vermont And State Agricultural College Compositions for inhibiting grb7
US7393531B2 (en) * 2003-01-21 2008-07-01 Arius Research Inc. Cytotoxicity mediation of cells evidencing surface expression of MCSP
CA2587018A1 (en) * 2004-11-08 2006-05-18 University Of Maryland, Baltimore Tweak as a therapeutic target for treating central nervous system diseases associated with cerebral edema and cell death
KR20130089271A (ko) * 2005-03-07 2013-08-09 제넨테크, 인크. Tweak 및 fn14 활성을 조절하는 방법 및 조성물

Also Published As

Publication number Publication date
US20120269808A1 (en) 2012-10-25
RU2007137060A (ru) 2009-04-20
EP1853312A2 (en) 2007-11-14
ZA200707489B (en) 2008-12-31
WO2006096487A3 (en) 2007-09-13
JP2014111605A (ja) 2014-06-19
WO2006096487A2 (en) 2006-09-14
AU2006220825A2 (en) 2006-09-14
KR20070108537A (ko) 2007-11-12
CN101171035A (zh) 2008-04-30
KR20150031459A (ko) 2015-03-24
CA2597485A1 (en) 2006-09-14
AU2006220825A1 (en) 2006-09-14
IL185180A0 (en) 2008-12-29
JP2008531746A (ja) 2008-08-14
EP1853312B1 (en) 2014-12-10
BRPI0608012A2 (pt) 2009-11-03
US20080286271A1 (en) 2008-11-20
CN102225200A (zh) 2011-10-26

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