BRPI0608012A2 - método de tratamento de cáncer, método de aumento de atividade de célula nk, método de aumento de resposta ou atividade th1 inata, método de tratamento de uma disfunção mediada por th2, método de tratamento de uma doença imune, usos de uma molécula antagonista e uso de uma molécula agonista - Google Patents
método de tratamento de cáncer, método de aumento de atividade de célula nk, método de aumento de resposta ou atividade th1 inata, método de tratamento de uma disfunção mediada por th2, método de tratamento de uma doença imune, usos de uma molécula antagonista e uso de uma molécula agonistaInfo
- Publication number
- BRPI0608012A2 BRPI0608012A2 BRPI0608012-0A BRPI0608012A BRPI0608012A2 BR PI0608012 A2 BRPI0608012 A2 BR PI0608012A2 BR PI0608012 A BRPI0608012 A BR PI0608012A BR PI0608012 A2 BRPI0608012 A2 BR PI0608012A2
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- activity increase
- molecule
- response
- innate
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 12
- 230000000694 effects Effects 0.000 title abstract 5
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 239000000556 agonist Substances 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 3
- 239000005557 antagonist Substances 0.000 title abstract 2
- 208000026278 immune system disease Diseases 0.000 title abstract 2
- 210000000822 natural killer cell Anatomy 0.000 title abstract 2
- 230000004064 dysfunction Effects 0.000 title 1
- 230000001404 mediated effect Effects 0.000 title 1
- 102000016946 TWEAK Receptor Human genes 0.000 abstract 1
- 108010014401 TWEAK Receptor Proteins 0.000 abstract 1
- 102100024584 Tumor necrosis factor ligand superfamily member 12 Human genes 0.000 abstract 1
- 101710097155 Tumor necrosis factor ligand superfamily member 12 Proteins 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Microbiology (AREA)
- Transplantation (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65933905P | 2005-03-07 | 2005-03-07 | |
| PCT/US2006/007547 WO2006096487A2 (en) | 2005-03-07 | 2006-03-02 | Methods and compositions for modulating tweak and fn14 activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0608012A2 true BRPI0608012A2 (pt) | 2009-11-03 |
Family
ID=36953868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0608012-0A BRPI0608012A2 (pt) | 2005-03-07 | 2006-03-02 | método de tratamento de cáncer, método de aumento de atividade de célula nk, método de aumento de resposta ou atividade th1 inata, método de tratamento de uma disfunção mediada por th2, método de tratamento de uma doença imune, usos de uma molécula antagonista e uso de uma molécula agonista |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20080286271A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1853312B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2008531746A (cg-RX-API-DMAC7.html) |
| KR (3) | KR20130089271A (cg-RX-API-DMAC7.html) |
| CN (2) | CN101171035A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2006220825A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0608012A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2597485A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL185180A0 (cg-RX-API-DMAC7.html) |
| RU (1) | RU2007137060A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2006096487A2 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA200707489B (cg-RX-API-DMAC7.html) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0105044A3 (en) | 1999-01-15 | 2004-07-28 | Biogen Inc Cambridge | Antagonists of tweak and of tweak receptor and their use to treat immunological disorders |
| US7208151B2 (en) | 2001-09-12 | 2007-04-24 | Biogen Idec Ma Inc. | Tweak receptor agonists as anti-angiogenic agents |
| AU2003224950B2 (en) | 2002-04-09 | 2006-09-14 | Biogen Ma Inc. | Methods for treating tweak-related conditions |
| DK2332408T3 (da) | 2005-02-17 | 2013-12-02 | Biogen Idec Inc | Behandling af neurologiske sygdomme |
| WO2006088890A2 (en) * | 2005-02-17 | 2006-08-24 | Biogen Idec Ma Inc. | Treating stroke |
| KR20130089271A (ko) * | 2005-03-07 | 2013-08-09 | 제넨테크, 인크. | Tweak 및 fn14 활성을 조절하는 방법 및 조성물 |
| WO2006122187A2 (en) * | 2005-05-10 | 2006-11-16 | Biogen Idec Ma Inc. | Treating and evaluating inflammatory disorders |
| WO2006130429A2 (en) * | 2005-05-27 | 2006-12-07 | Biogen Idec Ma Inc. | Treatment of cancer |
| NZ583636A (en) | 2005-05-27 | 2011-12-22 | Biogen Idec Inc | Tweak binding antibodies |
| WO2006138219A2 (en) | 2005-06-13 | 2006-12-28 | Biogen Idec Ma Inc. | Methods of diagnosis / prognosis of inflammatory conditions |
| US20100284933A1 (en) * | 2006-10-16 | 2010-11-11 | Biogen Idec Ma Inc. | Biomarkers of Multiple Sclerosis |
| MX2010001378A (es) * | 2007-08-03 | 2010-06-02 | Facet Biotech Corp | Uso terapeutico de anticuerpos del receptor anti-tweak. |
| US8093006B2 (en) | 2009-04-02 | 2012-01-10 | Hoffmann-La Roche Inc. | Antibodies against human tweak and uses thereof |
| US20120055055A1 (en) * | 2010-09-02 | 2012-03-08 | Illumin8 Outdoor Media, LLC | Systems and Method for Outdoor Media Signage |
| WO2012045671A1 (en) * | 2010-10-05 | 2012-04-12 | F. Hoffmann-La Roche Ag | Antibodies against human tweak and uses thereof |
| JP5832559B2 (ja) * | 2011-03-10 | 2015-12-16 | オメロス コーポレーション | exvivoにおける加速された抗体進化による抗FN14モノクローナル抗体の生成 |
| JP2016000003A (ja) * | 2013-04-19 | 2016-01-07 | アステラス製薬株式会社 | 新規抗ヒトtweak抗体 |
| CN105779576B (zh) * | 2014-12-25 | 2025-01-17 | 中国人民解放军第四军医大学 | 人tnfrsf12a基因的用途及其相关药物 |
| US10994017B2 (en) | 2016-12-02 | 2021-05-04 | Avelas Biosciences, Inc. | Nerve labeling compositions and uses thereof |
| MY204672A (en) | 2018-10-31 | 2024-09-09 | Astellas Pharma Inc | Anti-human fn14 antibody |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998035061A2 (en) * | 1997-02-12 | 1998-08-13 | Abbott Laboratories | Member of the tnf family useful for treatment and diagnosis of disease |
| HUP0105044A3 (en) * | 1999-01-15 | 2004-07-28 | Biogen Inc Cambridge | Antagonists of tweak and of tweak receptor and their use to treat immunological disorders |
| EP1626058B1 (en) * | 1999-03-08 | 2007-10-31 | Genentech, Inc. | Compositions and methods for the diagnosis of tumour |
| US7442776B2 (en) * | 1999-10-08 | 2008-10-28 | Young David S F | Cancerous disease modifying antibodies |
| EP2298334A3 (en) * | 1999-12-20 | 2012-04-04 | Immunex Corporation | Tweak receptor |
| US6727225B2 (en) | 1999-12-20 | 2004-04-27 | Immunex Corporation | TWEAK receptor |
| CA2422095A1 (en) * | 2000-09-14 | 2002-03-21 | Biogen, Inc. | Tweak receptor agonists as anti-angiogenic agents |
| AU2002220265A1 (en) * | 2000-11-03 | 2002-05-15 | University Of Vermont And State Agricultural College | Compositions for inhibiting grb7 |
| US7393531B2 (en) * | 2003-01-21 | 2008-07-01 | Arius Research Inc. | Cytotoxicity mediation of cells evidencing surface expression of MCSP |
| CA2587018A1 (en) * | 2004-11-08 | 2006-05-18 | University Of Maryland, Baltimore | Tweak as a therapeutic target for treating central nervous system diseases associated with cerebral edema and cell death |
| KR20130089271A (ko) * | 2005-03-07 | 2013-08-09 | 제넨테크, 인크. | Tweak 및 fn14 활성을 조절하는 방법 및 조성물 |
-
2006
- 2006-03-02 KR KR1020137015784A patent/KR20130089271A/ko not_active Withdrawn
- 2006-03-02 BR BRPI0608012-0A patent/BRPI0608012A2/pt not_active Application Discontinuation
- 2006-03-02 AU AU2006220825A patent/AU2006220825A1/en not_active Abandoned
- 2006-03-02 CA CA002597485A patent/CA2597485A1/en not_active Abandoned
- 2006-03-02 KR KR20157002807A patent/KR20150031459A/ko not_active Ceased
- 2006-03-02 CN CNA2006800155970A patent/CN101171035A/zh active Pending
- 2006-03-02 RU RU2007137060/14A patent/RU2007137060A/ru unknown
- 2006-03-02 CN CN2011101610523A patent/CN102225200A/zh active Pending
- 2006-03-02 WO PCT/US2006/007547 patent/WO2006096487A2/en not_active Ceased
- 2006-03-02 US US11/908,074 patent/US20080286271A1/en not_active Abandoned
- 2006-03-02 ZA ZA200707489A patent/ZA200707489B/xx unknown
- 2006-03-02 KR KR1020077020346A patent/KR20070108537A/ko not_active Withdrawn
- 2006-03-02 JP JP2008500768A patent/JP2008531746A/ja not_active Withdrawn
- 2006-03-02 EP EP06736808.4A patent/EP1853312B1/en not_active Revoked
-
2007
- 2007-08-09 IL IL185180A patent/IL185180A0/en unknown
-
2011
- 2011-11-21 US US13/300,897 patent/US20120269808A1/en not_active Abandoned
-
2013
- 2013-12-27 JP JP2013271694A patent/JP2014111605A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20120269808A1 (en) | 2012-10-25 |
| RU2007137060A (ru) | 2009-04-20 |
| EP1853312A2 (en) | 2007-11-14 |
| ZA200707489B (en) | 2008-12-31 |
| WO2006096487A3 (en) | 2007-09-13 |
| JP2014111605A (ja) | 2014-06-19 |
| WO2006096487A2 (en) | 2006-09-14 |
| AU2006220825A2 (en) | 2006-09-14 |
| KR20070108537A (ko) | 2007-11-12 |
| CN101171035A (zh) | 2008-04-30 |
| KR20150031459A (ko) | 2015-03-24 |
| CA2597485A1 (en) | 2006-09-14 |
| AU2006220825A1 (en) | 2006-09-14 |
| IL185180A0 (en) | 2008-12-29 |
| JP2008531746A (ja) | 2008-08-14 |
| EP1853312B1 (en) | 2014-12-10 |
| KR20130089271A (ko) | 2013-08-09 |
| US20080286271A1 (en) | 2008-11-20 |
| CN102225200A (zh) | 2011-10-26 |
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