KR20130086144A - 항체 및 보존제를 포함하는 안정한 다중-투여 조성물 - Google Patents
항체 및 보존제를 포함하는 안정한 다중-투여 조성물 Download PDFInfo
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- KR20130086144A KR20130086144A KR1020127030515A KR20127030515A KR20130086144A KR 20130086144 A KR20130086144 A KR 20130086144A KR 1020127030515 A KR1020127030515 A KR 1020127030515A KR 20127030515 A KR20127030515 A KR 20127030515A KR 20130086144 A KR20130086144 A KR 20130086144A
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10164298 | 2010-05-28 | ||
| EP10164298.1 | 2010-05-28 | ||
| US35152210P | 2010-06-04 | 2010-06-04 | |
| US61/351,522 | 2010-06-04 | ||
| PCT/EP2011/058648 WO2011147921A1 (en) | 2010-05-28 | 2011-05-26 | Stable multi-dose compositions comprising an antibody and a preservative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20130086144A true KR20130086144A (ko) | 2013-07-31 |
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| KR1020127030515A Withdrawn KR20130086144A (ko) | 2010-05-28 | 2011-05-26 | 항체 및 보존제를 포함하는 안정한 다중-투여 조성물 |
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| Country | Link |
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| EP (1) | EP2575761B1 (enExample) |
| JP (3) | JP6294075B2 (enExample) |
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| AU (1) | AU2011257219B2 (enExample) |
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Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ534399A (en) | 2002-01-25 | 2008-08-29 | G2 Therapies Ltd | Monoclonal antibodies against extracellular loops of C5aR |
| ES2562627T3 (es) | 2008-02-20 | 2016-03-07 | Novo Nordisk A/S | Anticuerpos anti-C5aR humanizados |
| CA2728685A1 (en) | 2008-06-30 | 2010-01-07 | Novo Nordisk A/S | Anti-human interleukin-20 antibodies |
| US8454956B2 (en) | 2009-08-31 | 2013-06-04 | National Cheng Kung University | Methods for treating rheumatoid arthritis and osteoporosis with anti-IL-20 antibodies |
| EP2538973A2 (en) * | 2010-02-26 | 2013-01-02 | Novo Nordisk A/S | Stable antibody containing compositions |
| AU2011223710B2 (en) | 2010-03-01 | 2016-04-14 | Bayer Healthcare Llc | Optimized monoclonal antibodies against tissue factor pathway inhibitor (TFPI) |
| US20130136733A1 (en) | 2010-05-28 | 2013-05-30 | Novo Nordisk A/S | Stable Multi-Dose Compositions Comprising an Antibody and a Preservative |
| JP6141834B2 (ja) | 2011-06-06 | 2017-06-07 | ノヴォ ノルディスク アー/エス | 治療抗体 |
| WO2013123114A2 (en) * | 2012-02-16 | 2013-08-22 | Santarus, Inc. | Antibody formulations |
| US9592289B2 (en) | 2012-03-26 | 2017-03-14 | Sanofi | Stable IgG4 based binding agent formulations |
| ES2702246T3 (es) * | 2012-03-26 | 2019-02-28 | Sanofi Sa | Formulaciones de agente de unión IgG4 estables |
| US20140004131A1 (en) | 2012-05-04 | 2014-01-02 | Novartis Ag | Antibody formulation |
| WO2014015133A1 (en) | 2012-07-19 | 2014-01-23 | National Cheng Kung University | Treatment of osteoarthritis using il-20 antagonists |
| US8852588B2 (en) | 2012-08-07 | 2014-10-07 | National Cheng Kung University | Treating allergic airway disorders using anti-IL-20 receptor antibodies |
| US8603470B1 (en) | 2012-08-07 | 2013-12-10 | National Cheng Kung University | Use of IL-20 antagonists for treating liver diseases |
| US9592297B2 (en) * | 2012-08-31 | 2017-03-14 | Bayer Healthcare Llc | Antibody and protein formulations |
| TWI694836B (zh) | 2014-05-16 | 2020-06-01 | 英商葛蘭素史克智慧財產管理有限公司 | 抗體調配物 |
| JP6664467B2 (ja) | 2015-08-19 | 2020-03-13 | ファイザー・インク | 組織因子経路インヒビター抗体およびその使用 |
| US11918650B2 (en) * | 2017-05-05 | 2024-03-05 | Amgen Inc. | Pharmaceutical composition comprising bispecific antibody constructs for improved storage and administration |
| US20200113912A1 (en) | 2018-09-12 | 2020-04-16 | Silverback Therapeutics, Inc. | Methods and Compositions for the Treatment of Disease with Immune Stimulatory Conjugates |
| KR102337683B1 (ko) | 2018-09-21 | 2021-12-13 | 주식회사 녹십자 | 고효율 항-tfpi 항체 조성물 |
| WO2020257407A1 (en) | 2019-06-19 | 2020-12-24 | Silverback Therapeutics, Inc. | Anti-mesothelin antibodies and immunoconjugates thereof |
| WO2021094917A1 (en) * | 2019-11-13 | 2021-05-20 | Pfizer Inc. | Stable aqueous anti-tfpi antibody formulation |
| EP4106819A1 (en) | 2020-02-21 | 2022-12-28 | Silverback Therapeutics, Inc. | Nectin-4 antibody conjugates and uses thereof |
| KR20230047361A (ko) | 2020-07-01 | 2023-04-07 | 아르스 파마슈티컬스 인크. | 항-asgr1 항체 접합체 및 이의 용도 |
| CN116615454A (zh) | 2020-08-12 | 2023-08-18 | 先天制药公司 | 采用艾朵利单抗的皮下抗c5ar拮抗剂治疗方案 |
| WO2022063913A1 (en) * | 2020-09-24 | 2022-03-31 | Novo Nordisk A/S | Pharmaceutical formulation of concizumab and method of production thereof |
| CN112244025A (zh) * | 2020-11-27 | 2021-01-22 | 上海创宏生物科技有限公司 | 大分子蛋白和/或核酸用无菌处理剂及其制备方法和应用 |
| EP4609881A1 (en) * | 2022-10-26 | 2025-09-03 | Nihon Medi-Physics Co., Ltd. | Radioactive pharmaceutical composition |
| AU2024265540A1 (en) * | 2023-05-01 | 2025-10-30 | Regeneron Pharmaceuticals, Inc. | Multidose antibody drug products using phenol or benzyl alcohol |
Family Cites Families (127)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5567584A (en) | 1988-01-22 | 1996-10-22 | Zymogenetics, Inc. | Methods of using biologically active dimerized polypeptide fusions to detect PDGF |
| US20020099179A1 (en) | 1989-12-21 | 2002-07-25 | Linda K. Jolliffe | Cdr-grafted antibodies |
| DK261490D0 (da) | 1990-10-31 | 1990-10-31 | Novo Nordisk As | New pharmaceutical compound |
| US6165467A (en) | 1991-07-20 | 2000-12-26 | Yoshihide Hagiwara | Stabilized human monoclonal antibody preparation |
| US5789192A (en) | 1992-12-10 | 1998-08-04 | Schering Corporation | Mammalian receptors for interleukin-10 (IL-10) |
| US6685940B2 (en) | 1995-07-27 | 2004-02-03 | Genentech, Inc. | Protein formulation |
| JP3681206B2 (ja) | 1995-12-26 | 2005-08-10 | 株式会社三菱化学ヤトロン | 抗ファクターXa・ティシュファクターパスウェイインヒビター複合体モノクローナル抗体及びその使用 |
| US6084248A (en) | 1996-06-28 | 2000-07-04 | Seiko Epson Corporation | Thin film transistor, manufacturing method thereof, and circuit and liquid crystal display device using the thin film transistor |
| US5985614A (en) | 1996-08-30 | 1999-11-16 | Human Genome Sciences, Inc. | Polynucleotides encoding interleukin-19 |
| EP2065396A1 (en) | 1996-08-30 | 2009-06-03 | Human Genome Sciences, Inc. | Interleukin-19 |
| US5945511A (en) | 1997-02-20 | 1999-08-31 | Zymogenetics, Inc. | Class II cytokine receptor |
| CA2288994C (en) | 1997-04-30 | 2011-07-05 | Enzon, Inc. | Polyalkylene oxide-modified single chain polypeptides |
| EP1012260A4 (en) | 1997-07-16 | 2001-05-09 | Human Genome Sciences Inc | INTERLEUKINE-20 |
| US6486301B1 (en) | 1997-07-16 | 2002-11-26 | Human Genome Sciences, Inc. | Interleukin-20 |
| CA2298439A1 (en) | 1997-08-06 | 1999-02-18 | Zymogenetics, Inc. | Lipocalin homologs |
| US6576743B1 (en) | 1997-11-26 | 2003-06-10 | Zymogenetics, Inc. | Mammalian cytokine-like polypeptide-10 |
| JP4271850B2 (ja) | 1998-01-23 | 2009-06-03 | イミュネックス・コーポレーション | Il−18受容体 |
| EP1062332A2 (en) | 1998-03-09 | 2000-12-27 | Schering Corporation | Human receptor proteins; related reagents and methods |
| JP3868740B2 (ja) | 1998-03-10 | 2007-01-17 | ジェネンテック・インコーポレーテッド | 新規なポリペプチド及びそれをコードする核酸 |
| US7198789B2 (en) | 1998-03-17 | 2007-04-03 | Genetics Institute, Llc | Methods and compositions for modulating interleukin-21 receptor activity |
| CN1233476A (zh) | 1998-04-24 | 1999-11-03 | 陆道培 | 治疗急性白血病的药物及其制备方法 |
| AU5203199A (en) | 1998-05-26 | 1999-12-13 | Procter & Gamble Company, The | Chimeric molecules comprising an extracellular ligand binding domain of a receptor and an ige fc or constant region, and their use in an assay system |
| WO1999062934A1 (en) | 1998-06-05 | 1999-12-09 | Human Genome Sciences, Inc. | Interferon receptor hkaef92 |
| US7026448B2 (en) | 1998-09-01 | 2006-04-11 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| AU765584B2 (en) | 1998-09-17 | 2003-09-25 | Eli Lilly And Company | Protein formulations |
| US7087215B2 (en) * | 1998-12-21 | 2006-08-08 | Generex Pharmaceuticals Incorporated | Methods of administering and enhancing absorption of pharmaceutical agents |
| US6451286B1 (en) * | 1998-12-21 | 2002-09-17 | Generex Pharmaceuticals Incorporated | Pharmaceutical compositions for buccal and pulmonary administration comprising an alkali metal alkyl sulfate and at least three micelle-forming compounds |
| WO2000039161A1 (en) | 1998-12-31 | 2000-07-06 | Millennium Pharmaceuticals, Inc. | Class ii cytokine receptor-like proteins and nucleic acids encoding them |
| EP1210418B1 (en) | 1999-06-02 | 2010-08-18 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US20050060101A1 (en) | 1999-06-28 | 2005-03-17 | Bevilacqua Michael P. | Systems and methods for characterizing a biological condition or agent using precision gene expression profiles |
| ATE464062T1 (de) | 1999-10-04 | 2010-04-15 | Novartis Vaccines & Diagnostic | Stabilisierte flüssige pharmazeutische zusammensetzung enthaltend tfpi |
| KR100399156B1 (ko) * | 1999-11-19 | 2003-09-26 | 주식회사 엘지생명과학 | α-인터페론의 용액제형 |
| AU783473B2 (en) | 1999-12-23 | 2005-10-27 | Zymogenetics Inc. | Soluble interleukin-20 receptor |
| US6610286B2 (en) | 1999-12-23 | 2003-08-26 | Zymogenetics, Inc. | Method for treating inflammation using soluble receptors to interleukin-20 |
| EP1272211B1 (en) | 2000-04-07 | 2007-06-06 | Signal Coordinating Therapy, Inc. | Methods and compositions for treating neoplasms |
| US7015194B2 (en) | 2000-05-10 | 2006-03-21 | Novo Nordisk A/S | Pharmaceutical composition comprising factor VIIa and anti-TFPI |
| WO2002011753A1 (en) | 2000-08-04 | 2002-02-14 | Chugai Seiyaku Kabushiki Kaisha | Protein injection preparations |
| ATE342980T1 (de) | 2000-08-08 | 2006-11-15 | Zymogenetics Inc | Lösliche zcyctor 11 cytokinrezeptoren |
| EP2311492B1 (en) | 2000-08-11 | 2017-10-04 | Chugai Seiyaku Kabushiki Kaisha | Antibody-containing stabilized preparations |
| ES2332402T5 (es) | 2000-10-12 | 2018-05-14 | Genentech, Inc. | Formulaciones de proteína concentradas de viscosidad reducida |
| MXPA03007653A (es) | 2001-02-28 | 2003-12-04 | Lilly Co Eli | Uso de lp82 para tratar trastornos hematopoyeticos. |
| EP1399472B1 (en) | 2001-03-09 | 2009-06-03 | ZymoGenetics, Inc. | Soluble heterodimeric cytokine receptor |
| JP4317010B2 (ja) * | 2001-07-25 | 2009-08-19 | ピーディーエル バイオファーマ,インコーポレイティド | IgG抗体の安定な凍結乾燥医薬製剤 |
| EP1432431B1 (en) | 2001-10-04 | 2017-05-10 | Genetics Institute LLC | Methods and compositions for modulating interleukin-21 activity |
| US7022289B1 (en) | 2001-10-10 | 2006-04-04 | The United States Of America As Represented By The Secretary Of The Army | Chemical and biological sampling device and kit and method of use thereof |
| CN100374457C (zh) * | 2001-11-14 | 2008-03-12 | 森托科尔公司 | 抗il-6抗体、组合物、方法和用途 |
| ATE521361T1 (de) | 2001-12-17 | 2011-09-15 | Zymogenetics Inc | Verfahren zur behandlung von gebärmutterhalskrebs |
| DE60334678D1 (de) | 2002-02-14 | 2010-12-09 | Chugai Pharmaceutical Co Ltd | Antikörper enthaltende pharmazeutische lösungen |
| EP1478394B1 (en) | 2002-02-27 | 2008-07-30 | Immunex Corporation | Stabilized TNFR-Fc composition comprising arginine |
| WO2003082212A2 (en) | 2002-03-27 | 2003-10-09 | The Governement Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Method for treating cancer in humans |
| US20040009168A1 (en) * | 2002-04-05 | 2004-01-15 | Elizabet Kaisheva | Multidose antibody formulation |
| AU2003243415A1 (en) | 2002-06-07 | 2003-12-22 | Zymogenetics, Inc. | Use of il-21 in cancer and other therapeutic applications |
| US7425618B2 (en) | 2002-06-14 | 2008-09-16 | Medimmune, Inc. | Stabilized anti-respiratory syncytial virus (RSV) antibody formulations |
| US20040022792A1 (en) | 2002-06-17 | 2004-02-05 | Ralph Klinke | Method of stabilizing proteins at low pH |
| EP1551875A4 (en) | 2002-06-21 | 2006-06-28 | Biogen Idec Inc | TAMPON PREPARATIONS FOR CONCENTRATING ANTIBODIES AND METHODS FOR USE THEREOF |
| BR0312767A (pt) | 2002-07-18 | 2005-05-03 | Perini Fabio Spa | Unidade de armazenamento para produtos alongados |
| US20040033228A1 (en) | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
| US20040191243A1 (en) * | 2002-12-13 | 2004-09-30 | Bei Chen | System and method for stabilizing antibodies with histidine |
| EP1592440A4 (en) | 2003-02-10 | 2007-07-11 | Elan Pharm Inc | IMMUNOGLOBULIN PREPARATION AND METHOD OF PRODUCING THE SAME |
| HRP20050934B1 (hr) | 2003-04-04 | 2014-09-26 | Genentech, Inc. | Formulacije s visokom koncentracijom antitijela i proteina |
| TWI503328B (zh) | 2003-07-15 | 2015-10-11 | Amgen Inc | 作為選擇性神經生長因子(ngf)通道抑制劑之人類抗-ngf中和抗體 |
| WO2005033143A1 (ja) | 2003-10-01 | 2005-04-14 | Kyowa Hakko Kogyo Co., Ltd. | 抗体の安定化方法及び安定化された溶液状抗体製剤 |
| WO2005063291A1 (ja) | 2003-12-25 | 2005-07-14 | Kirin Beer Kabushiki Kaisha | 抗体を含有する安定な水性医薬製剤 |
| CA2564791A1 (en) | 2004-06-14 | 2005-12-29 | Medimmune Vaccines, Inc. | High pressure spray-dry of bioactive materials |
| JP4898691B2 (ja) | 2004-10-22 | 2012-03-21 | ザイモジェネティクス, インコーポレイテッド | 抗il−22ra抗体および結合パートナー、ならびに炎症における使用法 |
| EP1856156A2 (en) | 2005-02-08 | 2007-11-21 | ZymoGenetics, Inc. | Anti-il-20, anti-il-22 and anti-il-22ra antibodies and binding partners and methods of using in inflammation |
| US7525604B2 (en) | 2005-03-15 | 2009-04-28 | Naxellent, Llc | Windows with electrically controllable transmission and reflection |
| US20090148406A1 (en) | 2005-07-02 | 2009-06-11 | Arecor Limited | Stable Aqueous Systems Comprising Proteins |
| WO2007006858A2 (en) | 2005-07-12 | 2007-01-18 | Oy Jurilab Ltd | Method for treatment of cardiovascular and metabolic diseases and detecting the risk of the same |
| US7790679B2 (en) * | 2005-08-05 | 2010-09-07 | Amgen Inc. | Pharmaceutical formulations |
| CA2624359A1 (en) | 2005-09-27 | 2007-04-05 | Source Mdx | Gene expression profiling for identification monitoring and treatment of rheumatoid arthritis |
| WO2007038501A2 (en) | 2005-09-27 | 2007-04-05 | The Feinstein Institute For Medical Research | Rheumatoid arthritis markers |
| EP1951865A4 (en) | 2005-11-21 | 2010-06-23 | Sanofi Pasteur Ltd | STABILIZING FORMULATIONS FOR RECOMBINANT VIRUSES |
| WO2007076062A2 (en) | 2005-12-21 | 2007-07-05 | Wyeth | Protein formulations with reduced viscosity and uses thereof |
| US9084777B2 (en) | 2005-12-28 | 2015-07-21 | Chugai Seiyaku Kabushiki Kaisha | Stabilized antibody-containing formulations |
| WO2007092772A2 (en) | 2006-02-03 | 2007-08-16 | Medimmune, Inc. | Protein formulations |
| DE102006005094A1 (de) | 2006-02-04 | 2007-08-09 | Degussa Gmbh | Titandioxid und Polycarboxylatether enthaltende Dispersion |
| TW200744634A (en) | 2006-02-21 | 2007-12-16 | Wyeth Corp | Methods of using antibodies against human IL-22 |
| CN101405685A (zh) | 2006-03-15 | 2009-04-08 | 皇家飞利浦电子股份有限公司 | 具有滚动检测的遥控指向技术 |
| TW200806317A (en) | 2006-03-20 | 2008-02-01 | Wyeth Corp | Methods for reducing protein aggregation |
| CA2644663A1 (en) | 2006-03-23 | 2007-09-27 | Kirin Pharma Kabushiki Kaisha | Agonist antibody to human thrombopoietin receptor |
| JP2009531371A (ja) * | 2006-03-28 | 2009-09-03 | エフ.ホフマン−ラ ロシュ アーゲー | 抗igf−1rヒト・モノクローナル抗体製剤 |
| EP1857559A1 (en) | 2006-05-16 | 2007-11-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A method for predicting responsiveness to TNF alpha blocking agents |
| KR20090021298A (ko) | 2006-06-14 | 2009-03-02 | 임클론 시스템즈 인코포레이티드 | 항-egfr 항체의 동결건조 제제 |
| US20080031882A1 (en) | 2006-06-19 | 2008-02-07 | Liang Spencer C | Methods of modulating IL-22 and IL-17 |
| MX2008015830A (es) | 2006-06-30 | 2009-01-09 | Novo Nordisk As | Anticuerpos anti-nkg2a y usos de los mismos. |
| TW200831129A (en) | 2006-10-06 | 2008-08-01 | Amgen Inc | Stable formulations |
| WO2008045563A2 (en) | 2006-10-12 | 2008-04-17 | Wyeth | Modification of ionic strength in antibody-solutions to reduce opalescence/aggregates |
| US20100267575A1 (en) | 2006-10-17 | 2010-10-21 | Childrens Hospital Medical Center | Gene array technique for predicting response in inflammatory bowel diseases |
| EP2084298A1 (en) | 2006-11-09 | 2009-08-05 | Institut National De La Sante Et De La Recherche Medicale | Method for predicting therapeutic responsiveness to tnf-alpha blocking agents |
| AU2007331712A1 (en) | 2006-12-11 | 2008-06-19 | F. Hoffmann-La Roche Ag | Abeta antibody parenteral formulation |
| TW200837080A (en) * | 2007-01-09 | 2008-09-16 | Wyeth Corp | Anti-IL-13 antibody formulations and uses thereof |
| US20100273671A1 (en) | 2007-03-01 | 2010-10-28 | Universite Catholique De Louvain | Method for the determination and the classification of rheumatic conditions |
| CN101601127B (zh) | 2007-03-23 | 2011-02-16 | 松下电器产业株式会社 | 导电性凸起及其制造方法以及电子部件安装结构体 |
| WO2008121615A2 (en) | 2007-03-30 | 2008-10-09 | Medimmune, Inc. | Antibody formulation |
| GB0707938D0 (en) | 2007-04-25 | 2007-05-30 | Univ Strathclyde | Precipitation stabilising compositions |
| WO2008132176A2 (en) | 2007-04-27 | 2008-11-06 | Universite Catholique De Louvain | Method for evaluating the response of an individual to tnf blocking therapy |
| SG182183A1 (en) | 2007-06-08 | 2012-07-30 | Biogen Idec Inc | Biomarkers for predicting anti-tnf responsiveness or non-responsiveness |
| US20090208492A1 (en) | 2007-06-14 | 2009-08-20 | Elan Pharmaceuticals, Inc. | Lyophilized Immunoglobulin Formulations and Methods of Preparation |
| LT2170390T (lt) | 2007-06-14 | 2019-01-10 | Biogen Ma Inc. | Natalizumabo antikūnų kompozicijos |
| US20090004189A1 (en) | 2007-06-18 | 2009-01-01 | Genentech, Inc. | Biological markers predictive of rheumatoid arthritis response to b-cell antagonists |
| CA2692165A1 (en) | 2007-06-25 | 2008-12-31 | Amgen Inc. | Compositions of specific binding agents to hepatocyte growth factor |
| US20100189721A1 (en) | 2007-07-06 | 2010-07-29 | Smithkline Beecham Corporation | Antibody formulations |
| UA107557C2 (xx) | 2007-07-06 | 2015-01-26 | Композиція антитіла офатумумабу | |
| WO2009013538A2 (en) | 2007-07-20 | 2009-01-29 | National Institute For Bioprocessing Research And Training | Glycosylation markers for cancer and chronic inflammation |
| US20100261613A1 (en) | 2007-07-26 | 2010-10-14 | Michael Centola | Methods for inflammatory disease management |
| EP2225275A4 (en) | 2007-11-28 | 2013-04-03 | Medimmune Llc | PROTEIN FORMULATION |
| KR101615935B1 (ko) | 2007-12-14 | 2016-04-28 | 노보 노르디스크 에이/에스 | 인간 nkg2d에 대한 항체 및 그것의 용도 |
| ES2562627T3 (es) | 2008-02-20 | 2016-03-07 | Novo Nordisk A/S | Anticuerpos anti-C5aR humanizados |
| WO2009120684A1 (en) | 2008-03-25 | 2009-10-01 | Medimmune, Llc | Antibody formulation |
| WO2009138484A2 (en) | 2008-05-15 | 2009-11-19 | Novo Nordisk A/S | Antibody purification process |
| TWI451876B (zh) * | 2008-06-13 | 2014-09-11 | Lilly Co Eli | 聚乙二醇化之離脯胰島素化合物 |
| CA2728685A1 (en) | 2008-06-30 | 2010-01-07 | Novo Nordisk A/S | Anti-human interleukin-20 antibodies |
| UA112050C2 (uk) * | 2008-08-04 | 2016-07-25 | БАЄР ХЕЛСКЕР ЛЛСі | Терапевтична композиція, що містить моноклональне антитіло проти інгібітора шляху тканинного фактора (tfpi) |
| US20110159011A1 (en) | 2008-08-28 | 2011-06-30 | Wyeth Llc | Uses of il-22, il-17, and il-1 family cytokines in autoimmune diseases |
| CA2736198A1 (en) | 2008-09-19 | 2010-03-25 | F. Hoffmann-La Roche Ag | Novel antibody formulation |
| EP2196476A1 (en) | 2008-12-10 | 2010-06-16 | Novartis Ag | Antibody formulation |
| CA2745317C (en) | 2008-12-22 | 2019-03-05 | Ida Hilden | Antibodies against tissue factor pathway inhibitor |
| EP2414542B1 (en) | 2009-03-30 | 2017-08-30 | Tel HaShomer Medical Research Infrastructure and Services Ltd. | Methods of predicting clinical course and treating multiple sclerosis |
| MX2012002766A (es) | 2009-09-03 | 2012-04-02 | Genentech Inc | Metodos para el tratamiento, diagnosis y monitoreo de artritis reumatoide. |
| WO2011047073A2 (en) | 2009-10-16 | 2011-04-21 | Mayo Foundation For Medical Education And Research | Assessing rheumatoid arthritis |
| US8580528B2 (en) | 2009-10-16 | 2013-11-12 | Stichting Vu-Vumc | Method for prognosticating the clinical response of a patient to B-lymphocyte inhibiting or depleting therapy |
| EP2538973A2 (en) | 2010-02-26 | 2013-01-02 | Novo Nordisk A/S | Stable antibody containing compositions |
| US20130136733A1 (en) | 2010-05-28 | 2013-05-30 | Novo Nordisk A/S | Stable Multi-Dose Compositions Comprising an Antibody and a Preservative |
| CN103119176A (zh) | 2010-06-07 | 2013-05-22 | 霍夫曼-拉罗奇有限公司 | 用于预测对白介素-6受体抑制性单克隆抗体药物治疗的响应的基因表达标记 |
| US8603470B1 (en) | 2012-08-07 | 2013-12-10 | National Cheng Kung University | Use of IL-20 antagonists for treating liver diseases |
-
2011
- 2011-05-26 US US13/699,847 patent/US20130136733A1/en not_active Abandoned
- 2011-05-26 RU RU2012153786/10A patent/RU2012153786A/ru unknown
- 2011-05-26 HR HRP20241526TT patent/HRP20241526T1/hr unknown
- 2011-05-26 BR BR112012030139A patent/BR112012030139A2/pt not_active IP Right Cessation
- 2011-05-26 EP EP11721544.2A patent/EP2575761B1/en active Active
- 2011-05-26 MX MX2012013586A patent/MX2012013586A/es unknown
- 2011-05-26 CA CA2800188A patent/CA2800188A1/en not_active Withdrawn
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- 2011-05-26 RS RS20241258A patent/RS66182B1/sr unknown
- 2011-05-26 ES ES11721544T patent/ES2993022T3/es active Active
- 2011-05-26 CN CN201510485529.1A patent/CN105055306B/zh active Active
- 2011-05-26 JP JP2013511686A patent/JP6294075B2/ja active Active
- 2011-05-26 KR KR1020127030515A patent/KR20130086144A/ko not_active Withdrawn
- 2011-05-26 CN CN201180026538.4A patent/CN102905692B/zh active Active
- 2011-05-26 AU AU2011257219A patent/AU2011257219B2/en not_active Withdrawn - After Issue
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2016
- 2016-02-09 JP JP2016022657A patent/JP6239657B2/ja active Active
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2017
- 2017-10-31 US US15/799,276 patent/US10835602B2/en active Active
- 2017-11-01 JP JP2017211614A patent/JP6568917B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP6568917B2 (ja) | 2019-08-28 |
| RU2012153786A (ru) | 2014-07-10 |
| BR112012030139A2 (pt) | 2017-06-13 |
| EP2575761C0 (en) | 2024-08-14 |
| EP2575761B1 (en) | 2024-08-14 |
| MX2012013586A (es) | 2013-01-24 |
| US20180104335A1 (en) | 2018-04-19 |
| US20130136733A1 (en) | 2013-05-30 |
| CN102905692A (zh) | 2013-01-30 |
| RS66182B1 (sr) | 2024-12-31 |
| EP2575761A1 (en) | 2013-04-10 |
| JP2016084367A (ja) | 2016-05-19 |
| JP2018030879A (ja) | 2018-03-01 |
| HRP20241526T1 (hr) | 2025-01-03 |
| CN105055306A (zh) | 2015-11-18 |
| CA2800188A1 (en) | 2011-12-01 |
| CN105055306B (zh) | 2019-10-01 |
| US10835602B2 (en) | 2020-11-17 |
| AU2011257219B2 (en) | 2014-12-04 |
| CN102905692B (zh) | 2015-09-16 |
| AU2011257219A1 (en) | 2012-11-22 |
| JP6294075B2 (ja) | 2018-03-14 |
| JP6239657B2 (ja) | 2017-11-29 |
| ES2993022T3 (en) | 2024-12-20 |
| WO2011147921A1 (en) | 2011-12-01 |
| JP2013527189A (ja) | 2013-06-27 |
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| PC1202 | Submission of document of withdrawal before decision of registration |
Comment text: [Withdrawal of Procedure relating to Patent, etc.] Withdrawal (Abandonment) Patent event code: PC12021R01D Patent event date: 20150209 |
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| WITB | Written withdrawal of application |