KR20130074348A - 복수개의 단일 항체를 포함하는 단백질 복합체 - Google Patents

복수개의 단일 항체를 포함하는 단백질 복합체 Download PDF

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KR20130074348A
KR20130074348A KR1020110142384A KR20110142384A KR20130074348A KR 20130074348 A KR20130074348 A KR 20130074348A KR 1020110142384 A KR1020110142384 A KR 1020110142384A KR 20110142384 A KR20110142384 A KR 20110142384A KR 20130074348 A KR20130074348 A KR 20130074348A
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이재일
서혜영
최윤아
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삼성전자주식회사
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Abstract

2 이상의 단일 항체 단백질을 포함하는 단백질 복합체에 관한 것이다. 일 구체예에 따른 단백질 복합체를 이용하면, 2 이상의 항원을 동시에 표적으로 하는 시스템을 효과적으로 구축할 수 있다.

Description

복수개의 단일 항체를 포함하는 단백질 복합체{Protein complex comprising multi-specific monoclonal antibodies}
2 이상의 단일 항체 단백질을 포함하는 단백질 복합체에 관한 것이다.
단일 클론 항체가 신약 시장의 강자로 자리매김하면서 다양한 표적에 대한 치료제로 개발되고 있으나, 많은 경우 만족할 만한 약효를 보이지 못하거나, 항체 생산에 고비용이 드는 등 신약 개발에 있어 한계를 지니고 있다. 이러한 문제점 해결을 위한 하나의 방법으로 1980년 중반 이후 이중 특이 항체에 대한 연구가 꾸준히 진행되고 있으나, 많은 노력에도 불구하고 아직 주도적인 기술은 나타나지 않고 있다.
기존의 이중 특이 항체 제조법은 동질의 이중 특이 항체를 대량 생산하는데 어려움이 있거나, 낮은 효능과 부작용으로 인해 실용화에 어려움이 있었다. 최근 들어 항체 공학 기술의 발달에 힘입어 경쟁력이 있는 새로운 항체 플랫폼들이 나타나고 있으나, 아직 검증 단계에 머무르고 있는 실정이다.
따라서, 종래 기술에 의하더라도, 새로운 2 이상의 이종 항원에 특이성을 갖는 단백질 복합체의 개발이 요구된다.
일 구체예는 다중특이 항체의 제작을 위한 단백질 복합체를 제공한다.
다른 구체예는 상기 단백질 복합체를 코딩하는 폴리뉴클레오티드, 이를 포함하는 재조합 벡터 및 이를 포함하는 숙주세포를 제공한다.
또 다른 구체예는 상기 단백질 복합체를 이용한 다중특이 항체의 제조 방법을 제공한다.
일 양상은 항원 결합 부위를 포함하는 2 이상의 폴리펩티드; 및 상기 2 이상의 폴리펩티드를 서로 연결하는 링커를 포함하는 것으로서, 상기 링커는 양 말단 중 적어도 하나의 말단에 태그를 포함하고, 상기 태그는 상기 폴리펩티드의 말단에 연결되며, 절단 가능한 아미노산 서열을 포함하는 것인 단백질 복합체를 제공한다.
상기 단백질 복합체는 항원 결합 부위를 포함하는 폴리펩티드를 2 이상 포함할 수 있다.
용어, "항원 결합 부위(antigen binding site)"는 면역글로불린 분자 내에서 항원(antigen) 또는 에피토프(epitope)가 결합하는 부위를 총칭하는 개념으로 해석되며, 상기 항원 결합 부위는 CDR(complementarity determining region)을 포함할 수 있다. CDR은 면역글로불린의 중쇄 및 경쇄의 고가변 영역(hypervariable region)의 아미노산 서열을 의미한다. 중쇄 및 경쇄는 각각 3개의 CDR을 포함할 수 있으며(CDRH1, CDRH2, CDRH3 및 CDRL1, CDRL2, CDRL3). 상기 CDR은 항체가 항원 또는 에피토프에 결합하는 데 있어서 주요한 접촉 잔기를 제공할 수 있다. 용어, "중쇄(heavy chain)"는 항원에 특이성을 부여하기 위해 충분한 가변 영역 서열을 갖는 아미노산 서열을 포함하는 가변 영역 도메인 VH 및 3 개의 불변 영역 도메인 CH1, CH2 및 CH3를 포함하는 전장 중쇄 및 이의 단편을 모두 포함하는 의미로 해석된다. 또한, 용어 "경쇄(light chain)"는 항원에 특이성을 부여하기 위한 충분한 가변영역 서열을 갖는 아미노산 서열을 포함하는 가변 영역 도메인 VL 및 불변 영역 도메인 CL을 포함하는 전장 경쇄 및 이의 단편을 모두 포함하는 의미로 해석된다.
일 구체예에 따르면, 상기 항원 결합 부위는 상기 폴리펩티드의 N-말단에 위치하는 것일 수 있다.
일 구체예에 따르면, 상기 단백질 복합체는 서로 동일하거나, 서로 다른 항원 결합 부위를 가질 수 있다. 즉, 상기 2 이상의 폴리펩티드는 서로 동일하거나, 서로 다른 항원의 항원 결합 부위를 포함할 수 있다. 또한, 이는 항원이 동일한 경우라도, 서로 다른 에피토프(epitope)에 결합할 수 있는 항원 결합 부위를 포함하는 것으로 해석될 수 있다. 상기 항원 결합 부위에 결합될 수 있는 항원은 예를 들어, DLL4, VEGFR2, Notch1, Notch2, Notch3, Notch4, Notch(pan), JAG1, JAG2, DLL(pan), JAG(pan), ERBB(pan), c-Met, IGF-1R, PDGFR, Patched, Hedgehog family polypeptides, Hedgehog(pan), WNT family polypeptides, WNT(pan), FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, FZD10, FZD(pan), LRP5, LRP6, CD20, IL-17, CD86, Muc16, PSCA, CD44, c-Kit, DDR1, DDR2, RSPO1, RSPO2, RSPO3, RSPO4, RSPO(pan), BMP family polypeptides, BMP(pan), BMPR1a, BMPR1b 및 그의 조합으로 이루어진 군으로부터 선택되는 것일 수 있으나, 이에 한정하지는 않는다. 또한, 상기 항원 결합 부위에 결합될 수 있는 항원은 예를 들어, EpCAM, tumor-associated glycoprotein-72 (TAG-72), tumor-associated antigen CA 125, Prostate specific membrane antigen (PSMA), High molecular weight melanoma-associated antigen (HMW-MAA), tumor-associated antigen expressing Lewis Y related carbohydrate, Carcinoembryonic antigen (CEA), CEACAM5, HMFG PEM, mucin MUC1, MUC18 and cytokeratin tumor-associated antigen, bacterial antigens, viral antigens, allergens, fluorescein, lysozyme, toll-like receptor 9, erythropoietin, CD2, CD3, CD3E, CD4, CD11, CD11a, CD14, CD18, CD19, CD20, CD22, CD23, CD25, CD28, CD29, CD30, CD33 (p67 protein), CD38, CD40, CD40L, CD52, CD54, CD56, CD80, CD147, GD3, IL-1, IL-1R, IL-2, IL-2R, IL-4, IL-5, IL-6, IL-6R, IL-8, IL-12, IL-15, IL-18, IL-23, interferon alpha, interferon beta, interferon gamma; TNF-alpha, TNF-beta2, TNF-alpha, TNF-alphabeta, TNF-R1, TNF-R11, FasL, CD27L, CD30L, 4-1BBL, TRAIL, RANKL, TWEAK, APRIL, BAFF, LIGHT, VEG1, OX40L, TRAIL Receptor-1, A1 Adenosine Receptor, Lymphotoxin Beta Receptor, TACI, BAFF-R, EPO; LFA-3, ICAM-1, ICAM-3, integrin beta1, integrin beta2, integrin alpha4/beta7, integrin alpha2, integrin alpha3, integrin alpha4, integrin alpha5, integrin alpha6, integrin alphav, alphaVbeta3 integrin, FGFR-3, Keratinocyte Growth Factor, VLA-1, VLA-4, L-selectin, anti-Id, E-selectin, HLA, HLADR, CTLA-4, T cell receptor, B7-1, B7-2, VNRintegrin, TGFbeta1, TGFbeta2, eotaxin1, BLyS (B-lymphocyte Stimulator), complement C5, IgE, factor VII, CD64, CBL, NCA 90, EGFR (ErbB-1), Her2/neu (ErbB-2), Her3 (ErbB-3), Her4 (ErbB4), Tissue Factor, VEGF, VEGFR, endothelin receptor, VLA-4, blood group antigen과 같은 carbohydrate 및 그와 관계된 carbohydrate, Galili-Glycosylation, Gastrin, Gastrin receptors, tumor associated carbohydrate, Hapten NP-cap or NIP-cap, T cell receptor alpha/beta, E-selectin, digoxin, placental alkaline phosphatase (PLAP) 및 testicular PLAP-like alkaline phosphatase, transferrin receptor, Heparanase I, human cardiac myosin, Glycoprotein IIb/IIIa (GPIIb/IIIa), human cytomegalovirus (HCMV) gH envelope glycoprotein, HIV gpl20, HCMV, respiratory syncital virus RSV F, RSVF Fgp, VNRintegrin, Hep B gp120, CMV, gpIIbIIIa, HIV IIIB gp120 V3 loop, respiratory syncytial virus (RSV) Fgp, Herpes simplex virus (HSV) gD glycoprotein, HSV gB glycoprotein, HCMV gB envelope glycoprotein, Clostridium perfringens toxin 및 그의 단편으로 이루어진 군으로부터 선택되는 것일 수 있으나, 이에 한정하지는 않는다.
일 구체예에 따르면, 상기 항원 결합 부위를 포함하는 폴리펩티드는 항체 또는 항원 결합 단편일 수 있다. 상기 항체 또는 항원 결합 단편은, 예를 들어, Fab, Fab', Fv 및 scFv로 이루어진 군으로부터 선택되는 항체 단편의 중쇄 또는 단쇄, 또는 단일-도메인 항체(single-domain antibody)일 수 있으나, 이에 한정하지는 않는다. 완전한 항체는 2개의 전장(full length) 경쇄 및 2개의 전장 중쇄를 가지는 구조이며 각각의 경쇄는 중쇄와 이황화 결합(disulfide bond, SS-bond) 항체의 불변 영역은 중쇄 불변 영역과 경쇄 불변 영역으로 나뉘어지며, 중쇄 불변 영역은 감마(γ), 뮤(μ), 알파(α), 델타(δ) 및 엡실론(ε) 타입을 가지고, 서브클래스로 감마1(γ1), 감마2(γ2), 감마3(γ3), 감마4(γ4), 알파1(α1) 및 알파2(α2)를 가진다. 경쇄의 불변 영역은 카파(κ) 및 람다(λ) 타입을 가진다.
상기 항원 결합 단편은 면역글로불린 전체 구조에 대한 그의 단편으로, 항원이 결합할 수 있는 부분을 포함하는 폴리펩티드의 일부를 의미하는 것으로, 예를 들어, F(ab')2, Fab', Fab, Fv 또는 scFv일 수 있으나, 이에 한정하지 않는다. 상기 항원 결합 단편 중 Fab는 경쇄 및 중쇄의 가변영역과 경쇄의 불변 영역 및 중쇄의 첫 번째 불변 영역(CH1)을 가지는 구조로 1개의 항원 결합 부위를 가진다. Fab'는 중쇄 CH1 도메인의 C-말단에 하나 이상의 시스테인 잔기를 포함하는 힌지 영역(hinge region)을 가진다는 점에서 Fab와 차이가 있다. F(ab')2 항체는 Fab'의 힌지 영역의 시스테인 잔기가 디설파이드 결합을 이루면서 생성된다. Fv는 중쇄 가변부위 및 경쇄 가변부위만을 가지고 있는 최소의 항체조각으로 Fv 단편을 생성하는 재조합 기술은 당업계에 널리 공지되어 있다. 이중쇄 Fv(two-chain Fv)는 비공유 결합으로 중쇄 가변부위와 경쇄 가변부위가 연결되어 있고 단쇄 Fv(single-chain Fv)는 일반적으로 펩타이드 링커를 통하여 중쇄의 가변 영역과 단쇄의 가변 영역이 공유 결합으로 연결되거나 또는 C-말단에서 바로 연결되어 있어서 이중쇄 Fv와 같이 다이머와 같은 구조를 이룰 수 있다. 상기 항원 결합 단편은 단백질 가수분해 효소를 이용해서 얻을 수 있고(예를 들어, 전체 항체를 파파인으로 제한 절단하면 Fab를 얻을 수 있고 펩신으로 절단하면 F(ab')2 단편을 얻을 수 있다), 유전자 재조합 기술을 통하여 제작할 수 있다.
일 구체예에 따르면, 상기 단백질 복합체는 2 이상의 폴리펩티드를 서로 연결하는 링커를 포함할 수 있다. 상기 링커는 펩티드 링커일 수 있다. 상기 펩티드 링커는 당업계에 공지된 다양한 링커를 이용할 수 있으며, 예를 들어, 복수의 아미노산으로 이루어진 링커일 수 있다. 일 구체예에 따르면, 상기 링커는 예를 들어, 1 내지 100개 또는 2 내지 50개의 임의의 아미노산으로 이루어진 폴리펩티드일 수 있다.
상기 펩티드 링커는 상기 2 이상의 융합 단백질 사이를 충분한 거리로 이격시켜 각각의 융합 단백질이 적절한 기능을 하기 위한 적합한 이차 및 삼차 구조로 폴딩되도록 할 수 있다. 예를 들어, 상기 펩티드 링커는 Gly, Asn 및 Ser 잔기를 포함할 수 있으며, Thr 및 Ala과 같은 중성 아미노산들도 포함될 수 있다. 펩티드 링커에 적합한 아미노산 서열은 당 업계에 공지되어 있다. 한편, 상기 링커는 상기 융합 단백질의 기능에 영향을 미치지 않는 한도 내에서, 그 길이를 다양하게 결정할 수 있다.
일 구체예에 따르면, 상기 링커는 양 말단 중 적어도 하나의 말단에 태그를 포함할 수 있다. 또한, 상기 태그는 상기 폴리펩티드의 말단에 연결되며, 절단 가능한 아미노산 서열을 포함할 수 있다.
용어, "태그(tag)"는 상기 링커의 말단에 결합되어 있으며, 서로 다른 상기 폴리펩티드 사이를 연결하기 위한 매개가 되는 단백질 또는 폴리펩티드를 의미하는 것으로, 일 구체예에 따르면, 상기 태그는 상기 폴리펩티드의 N-말단 또는 C-말단에 연결된 것일 수 있다.
일 구체예에 따르면, 상기 태그는 인 비트로 또는 인 비보로 절단 가능한 아미노산 서열을 포함할 수 있다. 상기 인 비트로 또는 인 비보에서의 절단은 프로테아제에 의한 것일 수 있다. 일 구체예에 따르면, 상기 태그는 유비퀴틴, 유비퀴틴-유사 단백질 및 TEV 절단 펩티드(TEV cleavage peptide) 및 퓨린(furin) 절단 펩티드로 이루어진 군으로부터 선택되는 것일 수 있으나, 이에 한정하지는 않는다.
한편, 유비퀴틴(ubiquitin, Ub)은 자연계에서 발견되는 가장 보존적인 단백질로 76개의 아미노산 서열로 이루어져 있으며, 곤충, 송어 및 인간처럼 진화적으로 다양한 종들간의 완벽한 상동성을 보이는 수용성 단백질이다. 또한, 유비퀴틴은 pH의 변화에 대해 안정하고, 고온에서도 쉽게 변성되지 않으며, 프로테아제에 대해서도 안정성이 있는 단백질로 알려져 있다. 따라서, 유비퀴틴은 상기 단백질 복합체의 불용성을 개선할 수 있으며, 인 비트로 또는 인 비보에서 용이하게 절단될 수 있다.
상기 유비퀴틴 또는 유비퀴틴-유사 단백질(ubiquitin-like protein)은 야생형 유비퀴틴, 야생형 유비퀴틴-유사 단백질, 돌연변이 유비퀴틴 및 돌연변이 유비퀴틴-유사 단백질로 이루어진 군으로부터 선택되는 것일 수 있다. 상기 돌연변이 유비퀴틴은 야생형 유비퀴틴의 아미노산 서열을 다른 아미노산 서열로 바꾼 것을 의미하며, 예를 들면, 야생형 유비퀴틴의 Lys을 Arg으로 치환한 유비퀴틴, 야생형 유비퀴틴 C-말단 RGG를 RGA로 변경시킨 유비퀴틴을 포함한다. 일 구체예에 따르면, 상기 야생형 유비퀴틴의 Lys을 Arg으로 치환한 돌연변이형 유비퀴틴에서, 상기 치환은 야생형 유비퀴틴의 6, 11, 27, 29, 33, 48 및 63번째에 존재하는 Lys에서 이루어질 수 있으며, 치환은 상기 Lys의 위치에서 독립적으로 또는 조합하여 이루어질 수 있다. 상기 유비퀴틴-유사 단백질은 유비퀴틴과 그 특성이 유사한 단백질로, 예를 들어, Nedd8, SUMO-1, SUMO-2, NUB1, PIC1, UBL3, UBL5 및 ISG15로 이루어진 군으로부터 선택될 수 있으나, 이에 한정하지는 않는다.
일 구체예에 따르면, 상기 유비퀴틴 또는 유비퀴틴-유사 단백질은 상기 인 비트로 또는 인 비보에서의 절단을 위해 C-말단에 프로테아제에 의해 절단 가능한 아미노산 서열을 포함할 수 있다. 상기 프로테아제에 의해 절단 가능한 아미노산 서열은 당 업계에 공지된 검색 데이터베이스를 통해 확인할 수 있다. 예를 들어, http://www.expasy.org/tools/peptidecutter/peptidecutter_enzymes.html에서 검색되는 프로테아제 및 그의 절단 가능한 아미노산 서열을 이용할 수 있다. 상기 절단 가능한 아미노산 서열이 포함되는 경우, 상기 단백질 복합체는 인 비트로 또는 인 비보에서 상기 단백질 복합체에 포함된 상기 태그가 절단됨으로써, 2 이상의 융합 단백질이 이중 또는 다중 특이적 항원 결합 부위를 갖는 단백질 복합체로써 그 기능을 할 수 있다.
일 구체예에 따르면, 상기 단백질 복합체는 N-말단에 제1 항원 결합 부위를 포함하는 제1 폴리펩티드; N-말단에 제2 항원 결합 부위를 포함하는 제2 폴리펩티드; 및 상기 제1 폴리펩티드 및 제2 폴리펩티드를 서로 연결하는 링커를 포함하는 것으로서, 상기 링커는 양 말단에 제1 태그 및 제2 태그를 포함하고, 상기 제1 태그는 상기 제1 폴리펩티드의 C-말단에, 상기 제2 태그는 상기 제2 폴리펩티드의 N-말단에 연결되며, 상기 제1 태그 및 제2 태그는 각각 절단 가능한 아미노산 서열을 포함하는 것인 단백질 복합체일 수 있다.
또한, 일 구체예에 따르면, 상기 단백질 복합체는 N-말단에 제1 항원 결합 부위를 포함하는 제1 폴리펩티드; N-말단에 제2 항원 결합 부위를 포함하는 제2 폴리펩티드; 및 상기 제1 폴리펩티드 및 제2 폴리펩티드를 서로 연결하는 링커를 포함하는 것으로서, 상기 링커는 하나의 말단에 태그를 포함하고, 상기 태그는 상기 제1 폴리펩티드의 C-말단 또는 상기 제2 폴리펩티드의 N-말단에 연결되며, 절단 가능한 아미노산 서열을 포함하는 것인 단백질 복합체일 수 있다.
일 구체예에 따르면, 상기 폴리펩티드는 서열번호 8 내지 서열번호 44로 이루어진 군으로부터 선택되는 아미노산 서열을 갖는 것일 수 있다.
다른 양상은 항원 결합 부위를 포함하는 2 이상의 폴리펩티드; 및 상기 2 이상의 폴리펩티드를 서로 연결하는 링커를 포함하는 것으로서, 상기 링커는 양 말단 중 적어도 하나의 말단에 태그를 포함하고, 상기 태그는 상기 폴리펩티드의 말단에 연결되며, 절단 가능한 아미노산 서열을 포함하는 것인 단백질 복합체를 코딩하는 폴리뉴클레오티드를 제공한다.
용어 “폴리뉴클레오티드(polynucleotide)”는 단일가닥 또는 이중가닥 형태로 존재하는 디옥시리보뉴클레오티드 또는 리보뉴클레오티드의 중합체이다. RNA 게놈 서열, DNA(gDNA 및 cDNA) 및 이로부터 전사되는 RNA 서열을 포괄하며, 특별하게 다른 언급이 없는 한 자연의 폴리뉴클레오티드의 유사체를 포함한다.
상기 폴리뉴클레오티드는 상기 단백질 복합체의 아미노산 서열을 코딩하는 뉴클레오티드 서열뿐만 아니라, 그 서열에 상보적인(complementary) 서열도 포함한다. 상기 상보적인 서열은 완벽하게 상보적인 서열뿐만 아니라, 실질적으로 상보적인 서열도 포함하며, 이는 당업계에 공지된 엄격 조건(stringent conditions) 하에서, 예를 들어, 상기 단백질 복합체의 아미노산 서열을 코딩하는 뉴클레오티드 서열의 뉴클레오티드 서열과 혼성화될 수 있는 서열을 의미한다.
또한, 상기 단백질 복합체의 아미노산 서열을 코딩하는 뉴클레오티드 서열은 변형될 수 있다. 상기 변형은 뉴클레오티드의 추가, 결실 또는 비보존적 치환 또는 보존적 치환을 포함한다. 상기 단백질 복합체의 아미노산 서열을 코딩하는 폴리뉴클레오티드는 상기 뉴클레오티드 서열에 대하여 실질적인 동일성을 나타내는 뉴클레오티드 서열도 포함하는 것으로 해석된다. 상기의 실질적인 동일성은, 상기 뉴클레오티드 서열과 임의의 다른 서열을 최대한 대응되도록 얼라인하고, 당업계에서 통상적으로 이용되는 알고리즘을 이용하여 얼라인된 서열을 분석한 경우에, 최소 80%의 상동성, 최소 90%의 상동성 또는 최소 95%의 상동성을 나타내는 서열일 수 있다.
일 구체예에 따르면, 상기 폴리뉴클레오티드는 서열번호 45 내지 서열번호 81로 이루어진 군으로부터 선택되는 염기서열을 갖는 것일 수 있다.
또 다른 양상은 항원 결합 부위를 포함하는 2 이상의 폴리펩티드; 및 상기 2 이상의 폴리펩티드를 서로 연결하는 링커를 포함하는 것으로서, 상기 링커는 양 말단 중 적어도 하나의 말단에 태그를 포함하고, 상기 태그는 상기 폴리펩티드의 말단에 연결되며, 절단 가능한 아미노산 서열을 포함하는 것인 단백질 복합체를 코딩하는 폴리뉴클레오티드 및 상기 폴리뉴클레오티드에 작동적으로 연결된(operatively linked) 프로모터를 포함하는 재조합 벡터를 제공한다.
용어 "벡터(vector)"는 숙주 세포에서 목적 유전자를 발현시키기 위한 수단을 의미한다. 예를 들어, 플라스미드 벡터, 코즈미드 벡터 및 박테리오파아지 벡터, 아데노바이러스 벡터, 레트로바이러스 벡터 및 아데노-연관 바이러스 벡터와 같은 바이러스 벡터를 포함한다. 상기 재조합 벡터로 사용될 수 있는 벡터는 당업계에서 종종 사용되는 플라스미드 (예를 들면, pSC101, pGV1106, pACYC177, ColE1, pKT230, pME290, pBR322, pUC8/9, pUC6, pBD9, pHC79, pIJ61, pLAFR1, pHV14, pGEX 시리즈, pET 시리즈 및 pUC19 등), 파지 (예를 들면, λgt4λB, λ-Charon, λΔz1 및 M13 등) 또는 바이러스 (예를 들명, SV40 등)를 조작하여 제작될 수 있다.
상기 재조합 벡터에서 상기 단백질 복합체를 코딩하는 폴리뉴클레오티드는 프로모터에 작동적으로 연결될 수 있다. 용어 "작동적으로 연결된(operatively linked)"은 뉴클레오티드 발현 조절 서열(예를 들어, 프로모터 서열)과 다른 뉴클레오티드 서열 사이의 기능적인 결합을 의미한다. 따라서, 이에 의해 상기 조절 서열은 상기 다른 뉴클레오티드 서열의 전사 및/또는 해독을 조절할 수 있다.
상기 재조합 벡터는, 전형적으로 클로닝을 위한 벡터 또는 발현을 위한 벡터로서 구축될 수 있다. 상기 발현용 벡터는 당업계에서 식물, 동물 또는 미생물에서 외래의 단백질을 발현하는 데 사용되는 통상의 것을 사용할 수 있다. 상기 재조합 벡터는 당업계에 공지된 다양한 방법을 통해 구축될 수 있다.
상기 재조합 벡터는 원핵 세포 또는 진핵 세포를 숙주로 하여 구축될 수 있다. 예를 들어, 사용되는 벡터가 발현 벡터이고, 원핵 세포를 숙주로 하는 경우에는, 전사를 진행시킬 수 있는 강력한 프로모터 (예를 들어, pLλ프로모터, CMV promoter, trp 프로모터, lac 프로모터, tac 프로모터, T7 프로모터 등), 해독의 개시를 위한 라이보좀 결합 자리 및 전사/해독 종결 서열을 포함하는 것이 일반적이다. 진핵 세포를 숙주로 하는 경우에는, 벡터에 포함되는 진핵 세포에서 작동하는 복제원점은 f1 복제원점, SV40 복제원점, pMB1 복제원점, 아데노 복제원점, AAV 복제원점 및 BBV 복제원점 등을 포함하나, 이에 한정되는 것은 아니다. 또한, 포유동물 세포의 게놈으로부터 유래된 프로모터 (예를 들어, 메탈로티오닌 프로모터) 또는 포유동물 바이러스로부터 유래된 프로모터 (예를 들어, 아데노바이러스 후기 프로모터, 백시니아 바이러스 7.5K 프로모터, SV40 프로모터, 사이토메갈로바이러스 프로모터 및 HSV의 tk 프로모터)가 이용될 수 있으며, 전사 종결 서열로서 폴리아데닐화 서열을 일반적으로 갖는다.
다른 양상은 항원 결합 부위를 포함하는 2 이상의 폴리펩티드; 및 상기 2 이상의 폴리펩티드를 서로 연결하는 링커를 포함하는 것으로서, 상기 링커는 양 말단 중 적어도 하나의 말단에 태그를 포함하고, 상기 태그는 상기 폴리펩티드의 말단에 연결되며, 절단 가능한 아미노산 서열을 포함하는 것인 단백질 복합체를 코딩하는 폴리뉴클레오티드 및 상기 폴리뉴클레오티드에 작동적으로 연결된 프로모터를 포함하는 재조합 벡터를 포함하는 숙주세포를 제공한다.
상기 재조합 벡터를 안정되면서 연속적으로 클로닝 또는 발현시킬 수 있는 숙주 세포는 당업계에 공지된 어떠한 숙주 세포도 이용할 수 있으며, 원핵 세포로는, 예를 들어, E. coli JM109, E. coli BL21, E. coli RR1, E. coli LE392, E. coli B, E. coli X 1776, E. coli W3110, 바실러스 서브틸리스, 바실러스 츄린겐시스와 같은 바실러스 속 균주, 그리고 살모넬라 티피무리움, 세라티아 마르세슨스 및 다양한 슈도모나스 종과 같은 장내균과 균주 등이 있으며, 진핵 세포에 형질 전환시키는 경우에는 숙주 세포로서, 효모(Saccharomyce cerevisiae), 곤충 세포, 식물 세포 및 동물 세포, 예를 들어, Sp2/0, CHO(Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS-7, 293, HepG2, Huh7, 3T3, RIN 및 MDCK 세포주 등이 이용될 수 있다.
상기 폴리뉴클레오티드 또는 이를 포함하는 재조합 벡터의 숙주 세포 내로의 운반은, 당업계에 널리 알려진 운반 방법을 사용할 수 있다. 상기 운반 방법은 예를 들어, 숙주 세포가 원핵 세포인 경우, CaCl2 방법 또는 전기 천공 방법 등을 사용할 수 있고, 숙주 세포가 진핵 세포인 경우에는, 미세 주입법, 칼슘 포스페이트 침전법, 전기 천공법, 리포좀-매개 형질감염법 및 유전자 밤바드먼트 등을 사용할 수 있으나, 이에 한정하지는 않는다.
상기 형질 전환된 숙주 세포를 선별하는 방법은 선택 표지에 의해 발현되는 표현형을 이용하여, 당업계에 널리 알려진 방법에 따라 용이하게 실시할 수 있다. 예를 들어, 상기 선택 표지가 특정 항생제 내성 유전자인 경우에는, 상기 항생제가 함유된 배지에서 형질전환체를 배양함으로써 형질전환체를 용이하게 선별할 수 있다.
또 다른 양상은 항원 결합 부위를 포함하는 2 이상의 폴리펩티드; 및 상기 2 이상의 폴리펩티드를 서로 연결하는 링커를 포함하는 것으로서, 상기 링커는 양 말단 중 적어도 하나의 말단에 태그를 포함하고, 상기 태그는 상기 폴리펩티드의 말단에 연결되며, 절단 가능한 아미노산 서열을 포함하는 것인 단백질 복합체를 코딩하는 폴리뉴클레오티드 및 상기 폴리뉴클레오티드에 작동적으로 연결된 프로모터를 포함하는 재조합 벡터를 발현시켜 상기 단백질 복합체를 생산하는 단계를 포함하는 다중특이 항체의 제조 방법을 제공한다.
상기 다중특이 항체를 제조하는 방법은 인 비보 또는 인 비트로에서 이루어질 수 있다.
상기 다중특이 항체가 인 비보에서 제작되는 경우, 상기 재조합 벡터를 세포 내에서 발현시켜 단백질 복합체를 생산하게 되면, 상기 단백질 복합체는 세포 내에서 완전한 다중특이 항체의 형태로 세포 외부로 방출될 수 있다. 즉, 상기 단백질 복합체는 소포체(endoplasmic reticulum)에서 번역(translation)이 일어난 후, 상기 2 이상의 폴리펩티드가 서로 인접하여 자발적으로 다량체를 형성하여 다중특이 항체를 형성할 수 있다. 이후 상기 단백질 복합체는 세포 내에 존재하는 프로테아제에 의해 상기 태그에 존재하는 절단 가능한 아미노산 서열이 절단됨으로써, 완전한 형태의 다중특이 항체가 생성될 수 있다. 상기 생성된 다중특이 항체는 당업계에 잘 알려진 정제 방법에 따라 정제하여 사용할 수 있다. 상기 폴리펩티드가 2 종류인 경우에는 상기 방법에 의해 이중특이 항체를 형성할 수 있다.
상기 다중특이 항체가 인 비트로로 제작되는 경우, 상기 재조합 벡터를 세포 내에서 발현시켜 상기 단백질 복합체를 생산하는 단계 이후, 상기 태그를 절단시키는 단계를 더 포함할 수 있다.
인 비트로에서 상기 단백질 복합체는 상기 2 이상의 폴리펩티드가 링커로 연결된 상태로 존재하며, 상기 2 이상의 폴리펩티드가 서로 인접하여 자발적으로 다량체를 형성할 수 있다. 상기 폴리펩티드가 2 종류인 경우에는 상기 방법에 의해 이중특이 항체를 형성할 수 있다.
일 구체예에 따르면, 상기 절단시키는 단계는 태그에 포함된 절단 가능한 아미노산 서열을 인식하는 프로테아제를 첨가하여 절단시키는 것일 수 있다. 또한, 상기 태그는 유비퀴틴, 유비퀴틴-유사 단백질, TEV 절단 펩티드 및 퓨린 절단 펩티드로 이루어진 군으로부터 선택될 수 있으나, 이에 한정하지는 않는다. 예를 들어, 상기 TEV 절단 펩티드 또는 퓨린 절단 펩티드를 절단할 수 있는 프로테아제를 상기 단백질 복합체에 첨가함으로써, 상기 TEV 절단 펩티드 또는 퓨린 절단 펩티드는 프로테아제에 의해 절단되어 분리되므로, 상기 단백질 복합체로부터 다중특이 항체 또는 이중특이 항체를 생성할 수 있게 된다.
일 구체예에 따른 단백질 복합체를 이용하면, 2 이상의 항원을 동시에 표적으로 하는 시스템을 효과적으로 구축할 수 있다.
도 1 및 도 2는 일 구체예에 따른 2 이상의 폴리펩티드를 포함하는 단백질 복합체의 개략도이다.
도 3은 일 구체예에 따른 단백질 복합체의 아미노산 서열 구조를 나타낸 것이다.
도 4는 일 구체예에 따른 단백질 복합체를 β-머캅토에탄올 미처리군(-), 처리군(+)으로 나누어 SDS-PAGE를 통해 확인한 결과이다.
도 5는 일 구체예에 따른 단백질 복합체의 다중특이적 항원-항체 반응 효과를 나타낸 센소그램(sensorgram)이다.
이하 하나 이상의 구체예를 실시예를 통하여 보다 상세하게 설명한다. 그러나, 이들 실시예는 하나 이상의 구체예를 예시적으로 설명하기 위한 것으로 본 발명의 범위가 이들 실시예에 한정되는 것은 아니다.
도 1 및 도 2는 일 구체예에 따른 항원 결합 부위를 포함하는 2 이상의 폴리펩티드를 포함하는 단백질 복합체의 개략도이다. 도 1에서 보는 바와 같이, 제1 항원 결합 부위(101)를 포함하는 제1 폴리펩티드(100) 및 제2 항원 결합 부위(201)를 포함하는 제2 폴리펩티드 (200)는 각각 그 말단에 제1 태그(102) 및 제2 태그(202)가 연결되어 있으며, 폴리펩티드로 이루어진 링커(300)의 말단에 상기 제1 태그(102) 및 제2 태그(202)가 연결되어 있다. 상기 제1 태그(102) 및 제2 태그(202)는 유비퀴틴 또는 유비퀴틴-유사 단백질과 같은 단백질로 이루어져 있으므로, 인 비트로 또는 인 비보로 절단이 가능하다. 인 비트로 또는 인 비보 상에서 상기 제1 항원 결합 부위(101)를 포함하는 제1 폴리펩티드(100) 및 제2 항원 결합 부위(201)를 포함하는 제2 폴리펩티드(200)는 완전한 자발적 결합을 통해서 서로 결합되어 서로 다른 항원 결합 부위를 갖는 다중특이적 단백질 복합체를 형성할 수 있다.
도 2는 도 1에 개시된 일 구체예에 따른 항원 결합 부위를 포함하는 2 이상의 폴리펩티드를 포함하는 단백질 복합체에서 제2 태그(201)가 없는 형태의 예를 나타낸다. 상기 설명한 바와 같이, 단백질 복합체의 인 비트로 또는 인 비보로 절단을 통해, 서로 다른 항원 결합 부위를 갖는 다중특이적 단백질 복합체를 형성하게 되며, 다만, 도 2에서 개시된 단백질 복합체는 제2 태그(201)이 없기 때문에, 제2 항원 결합 부위(201)를 포함하는 제2 폴리펩티드(200)에 링커(300)가 결합된 형태로 존재하지만, 상기 링커(300)는 2 내지 50개의 짧은 아미노산 서열을 포함하므로, 상기 제2 항원 결합 부위(201)를 포함하는 제2 폴리펩티드(200)의 기능에 영향을 미치지 않게 된다.
실시예 1: 2 종류의 항원 결합 부위를 포함하는 단백질 복합체의 발현 벡터의 제조
혈관 내피 성장인자(VEGF) 및 상피 성장인자 수용체(EGFR)에 대해 각각 특이적인 결합 부위를 포함하는 이중특이항체의 전구 단백질 복합체를 제조하기 위해, 상기 단백질 복합체의 발현 벡터를 GeneArt에 의뢰하여 제조하였으며, 단백질 과발현을 위한 벡터는 pCDNA 3.1 myc/his A (Invitrogen)를 사용하였다.
구체적으로, 도 3의 (A) 및 (B)에 개시된 바와 같은, 분비 신호 서열(signal sequence, ss)(서열번호 1), 혈관 내피 성장인자(VEGF) 결합 부위인 V1 또는 V2(서열번호 2 또는 3) 및 힌지(hinge)를 포함하는 Fc 도메인(서열번호 4)로 구성된 단일-도메인 항체, 상피 성장인자 수용체(EGFR) 결합 부위인 E1 또는 E2(서열번호 5 또는 6) 및 힌지(hinge)를 포함하는 Fc 도메인(서열번호 4)로 구성된 단일-도메인 항체, 적어도 하나의 유비퀴틴 태그(서열번호 7) 및 링커(Gly-Gly 또는 (Gly-Gly-Gly-Gly-Ser)n 펩티드)로 구성된 단백질 복합체의 아미노산 서열에 해당하는 단일서열 DNA(V1/V2 및 E1/E2, 링커의 길이, 유비퀴틴의 개수의 조합에 따라 총 37가지)를 합성하였다. 상기 단백질 복합체를 발현시키기 위해 플라스미드에 삽입되는 DNA 절편의 뉴클레오티드 서열을 서열번호 45 내지 서열번호 81에 나타내었다. 상기 삽입 DNA 절편은 5' 말단에 EcoRI로 절단될 수 있는 뉴클레오티드 서열을, 3' 말단에 XhoI으로 절단될 수 있는 뉴클레오티드 서열을 포함하여, pcDNA3.1 myc/his A 벡터의 EcoRI-Xho1 절단 서열에 삽입될 수 있다.
실시예 2: 단백질 복합체의 발현 및 이중특이 항체의 정제
상기 실시예 1에서 제조한 벡터를 이용하여 단백질 복합체를 과발현시키기 위해, 상기 벡터로 형질 전환된 Human embryonic kidney cell (HEK293-F, 한국 세포주 은행)를 이용하였다. HEK293-F 세포는 130 rpm의 오비탈 쉐이커(orbital shaker) 내 37 ℃, 8 % CO2 조건에서 유지하였다. 형질 전환을 위해 먼저 원심 분리를 통해 세포를 배지와 분리시키고 1 x 106 개의 세포를 다시 Freestyle 293 Expression media (Invitrogen)에 부유시킨 뒤, FreeStyleTM MAX reagent (Invitrogen)를 이용, 상기 벡터 100 ㎍을 사용하여 위 HEK293-F 세포를 형질 전환하였다. 형질 전환 후 7~8일 뒤에 원심 분리 (4000 x g, 10 min, 4 ℃)를 통해 상등액을 수집하고, 포어 사이즈 0.22 micron의 필터를 이용해 여과하였다. 이렇게 얻어진 상등액을 이중특이 항체의 정제에 사용하였다. 이중특이 항체는 Protein A affinity column (GE Healthcare)을 이용하여 분리하였다. 먼저, Protein A affinity column을 1X PBS (Invitrogen) 용액으로 평형화 시키고, 상기 상등액을 상기 용액으로 평형화된 Protein A affinity column에 적용시킨 다음, 컬럼 부피의 5배에 해당하는 세척 완충액(1X PBS)으로 세척하고, 10 % 글리세롤을 포함하는 용출 완충액(IgG elution buffer, Thermo Scientific)으로 상기 이중특이 항체를 용출하였다. 용출된 용액은 1 M Tris-HCl (pH 9.0) 용액으로 즉시 중화시켰다. Protein A affinity column을 통해 얻어진 용출액을 25 mM MES (pH 6.0) 용액으로 평형화되어 있는 desalting column(GE Healthcare)에 적용한 후, 상기 평형 용액을 컬럼에 흘려 주면서 UV 280 nm에서의 흡광도의 변화를 이용하여 용출된 단백질을 모아 하나의 샘플로 만들었다. 상기 단백질 샘플을 다시 상기 평형 용액으로 평형화 되어 있는 Mono S 컬럼(GE Healthcare)에 적용하였다. 컬럼에 결합하지 못한 단백질들은 상기 평형 용액의 적용을 통해 제거되었고, 컬럼에 결합된 단백질들은 25 mM MES 및 염(NaCl)으로 이루어진 세척 용액을 사용하여, 상기 염의 농도를 0 mM에서 250 mM까지 서서히 올려가며 적용하여 용출하였다. 이중특이 항체가 포함된 분획들을 280 nm에서의 흡광도와 SDS-PAGE를 통해 확인하였고 상기 분획들을 모아 Amicon Ultra-15 Centrifugal Filter(Milipore)를 이용하여 농축하였다. 정제된 단백질 농도는 BSA를 표준 물질로 사용하여 측정하였다. 이후, 상기 농축한 이중특이 항체를 SDS-PAGE를 통해 최종 확인하였다. 젤에 로딩하기 전에, 상기 이중특이 항체를 둘로 나누어, 한쪽은 1 mM의 β- 머캅토에탄올을 처리하였고, 다른 한쪽은 β- 머캅토에탄올을 처리하지 않은 상태로 로딩하였다. 그 결과, 도 2에 나타낸 바와 같이, β- 머캅토에탄올을 처리한 쪽은 VEGF의 결합 부위를 포함하는 단일-도메인 항체 및 EGFR의 결합 부위를 포함하는 단일-도메인 항체가 모노머(monomer)의 형태로 존재하는 것을 확인할 수 있었다.
실시예 3: 단백질 복합체로부터 제작된 이중특이 항체의 다중특이적 항원-항체 반응 확인
실시예 2에서 제조한 이중특이 항체의 다중특이적 항원-항체 반응의 결합 친화도 (binding affinity)를 측정하기 위해, BiacoreT100 instrument (GE healthcare)를 이용하여 표면 플라즈몬 공명 (Surface Plasmon resonance) 실험을 수행하였다. 런닝(running) 완충액 및 희석 완충액으로는 1X HBS-EP (GE healthcare)를 사용하였다. Anti-human IgG 항체 (Jackson Immuno Research)를 standard amine-coupling 반응을 이용하여 CM5 칩 (GE healthcare)의 표면에 약 5000 RU (response unit)로 고정하였다. 약 500 RU의 이중특이 항체를 흘려주어 표면에 결합하게 한 후, 여러 농도 (6.25 ~ 100 nM)의 인간 EGFR의 세포외 도메인 (Prospec) 또는 인간 VEGF (pangen)을 50 μL/min의 속도로 흘려주었다. 접촉 시간 (association phase)은 180초였고, 분리 시간 (런닝 완충액으로 세척)은 600초였다. 각각의 결합 싸이클이 끝난 후, 재생 용액인 Glycine-HCl pH 2.0 (GE healthcare)를 1분 동안 50 μL/min의 속도로 흘려주어 결합된 항원 및 항체를 칩으로부터 제거하였다. 이로부터 생성된 센소그램(sensorgram)은 EGFR의 경우 1:1 Langmuir binding model을, VEGF의 경우 bivalent analyte model을 사용하여 BIA evaluation software에서 fitting을 수행하였다. 그 결과를 도 3에 나타내었다.
VEGF와 EGFR이 단백질 복합체에 동시에 결합할 수 있음을 확인하기 위해, 상기와 동일한 방법으로 VEGF를 CM5 칩에 약 2500 RU로 고정하였다. 다음으로 이중특이 항체 (500 nM)를 10 μL/min의 속도로 1분 동안 흘려주었고, 이어서 EGFR (500 nM)을 동일 속도로 동일 시간 동안 흘려주었다. 표면은 상기 방법과 같이 Glycine-HCl pH 2.0 (GE healthcare)를 1분 동안 10 μL/min의 속도로 흘려주어 재생시켰다.
상기 실험 결과 나타난 이중특이 항체의 VEGF 또는 EGFR에 대한 항원 친화도(KD 값, dissociation constant)를 하기 표 1에 나타내었다. 하기 표 1에서 (V2Ub)2는 VEGF를 인식하는 단일특이 항체를, V2Ub-E2는 실시예 2에서 제조한 이중특이 항체를, (E2)2 는 EGFR을 인식하는 단일특이 항체를 의미한다.
(V2Ub)2 V2Ub-E2 (E2)2
VEGF에 대한 KD 값 (nM) 3.40 2.85 -
EGFR에 대한 KD 값 (nM) - 6.37 4.91
100: 제1 폴리펩티드
101: 제1 항원 결합 부위
102: 제1 태그
200: 제2 폴리펩티드
201: 제2 항원 결합 부위
202: 제2 태그
300: 링커
<110> Samsung Electronics Co. Ltd <120> Protein complex comprising multi-specific monoclonal antibodies <130> PN093630 <160> 81 <170> KopatentIn 1.71 <210> 1 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> signal sequence <400> 1 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser <210> 2 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> V1(binding site of VEGF) <400> 2 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Pro Glu 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr His Thr Ser Ile Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Met Phe Gln Pro Arg 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Arg Arg 100 105 <210> 3 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> V2(binding site of VEGF) <400> 3 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Lys Ile Phe Asn Gly 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr His Ser Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu Leu Tyr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4 <211> 232 <212> PRT <213> Artificial Sequence <220> <223> Fc domain containing Hinge region <400> 4 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 1 5 10 15 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 20 25 30 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 35 40 45 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 50 55 60 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 65 70 75 80 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 85 90 95 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 100 105 110 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 115 120 125 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 130 135 140 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 145 150 155 160 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 165 170 175 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 180 185 190 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 195 200 205 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 210 215 220 Ser Leu Ser Leu Ser Pro Gly Lys 225 230 <210> 5 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> E1(binding site of EGFR) <400> 5 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Ile Leu 20 25 30 Val Asp Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Ala Ser Phe Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu His Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Pro Ala Pro Leu 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 6 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> E2(binding site of EGFR) <400> 6 Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Asn Leu 20 25 30 Leu Asp Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Ala Ser Phe Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Gly Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Pro Ala Pro Leu 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 7 <211> 76 <212> PRT <213> Artificial Sequence <220> <223> ubiquitin tag <400> 7 Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 1 5 10 15 Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 20 25 30 Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys 35 40 45 Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 50 55 60 Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly 65 70 75 <210> 8 <211> 871 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #1 <400> 8 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile 35 40 45 Gly Pro Glu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Thr Ser Ile Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Met Phe 100 105 110 Gln Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Arg Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr 355 360 365 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 370 375 380 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 385 390 395 400 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 405 410 415 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 420 425 430 Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Met Gln Ile Phe Val Lys Thr Leu Thr 450 455 460 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 465 470 475 480 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 485 490 495 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 500 505 510 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 515 520 525 Arg Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 530 535 540 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile 545 550 555 560 Gly Ile Leu Val Asp Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys 565 570 575 Leu Leu Ile Tyr Tyr Ala Ser Phe Leu Gln Ser Gly Val Pro Ser Arg 580 585 590 Phe Ser Gly Ser Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 595 600 605 Leu His Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Pro 610 615 620 Ala Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu 625 630 635 640 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 645 650 655 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 660 665 670 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 675 680 685 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 690 695 700 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 705 710 715 720 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 725 730 735 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 740 745 750 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 755 760 765 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 770 775 780 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 785 790 795 800 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 805 810 815 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 820 825 830 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 835 840 845 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 850 855 860 Leu Ser Leu Ser Pro Gly Lys 865 870 <210> 9 <211> 876 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #2 <400> 9 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile 35 40 45 Gly Pro Glu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Thr Ser Ile Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Met Phe 100 105 110 Gln Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Arg Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr 355 360 365 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 370 375 380 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 385 390 395 400 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 405 410 415 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 420 425 430 Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Gln Ile Phe 450 455 460 Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser 465 470 475 480 Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile 485 490 495 Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp 500 505 510 Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His 515 520 525 Leu Val Leu Arg Leu Arg Gly Gly Asp Ile Gln Met Thr Gln Ser Pro 530 535 540 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 545 550 555 560 Ala Ser Gln Trp Ile Gly Ile Leu Val Asp Trp Tyr Gln Gln Lys Pro 565 570 575 Gly Glu Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Phe Leu Gln Ser 580 585 590 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Phe Gly Thr Asp Phe Thr 595 600 605 Leu Thr Ile Ser Ser Leu His Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 610 615 620 Gln Gln Ala Asn Pro Ala Pro Leu Thr Phe Gly Gln Gly Thr Lys Val 625 630 635 640 Glu Ile Lys Arg Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 645 650 655 Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 660 665 670 Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 675 680 685 Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 690 695 700 Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 705 710 715 720 Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 725 730 735 Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 740 745 750 Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 755 760 765 Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 770 775 780 Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 785 790 795 800 Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 805 810 815 Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 820 825 830 Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 835 840 845 Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 850 855 860 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 865 870 875 <210> 10 <211> 881 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #3 <400> 10 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile 35 40 45 Gly Pro Glu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Thr Ser Ile Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Met Phe 100 105 110 Gln Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Arg Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr 355 360 365 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 370 375 380 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 385 390 395 400 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 405 410 415 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 420 425 430 Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 450 455 460 Ser Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu 465 470 475 480 Glu Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln 485 490 495 Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly 500 505 510 Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys 515 520 525 Glu Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly Asp Ile Gln 530 535 540 Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 545 550 555 560 Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Ile Leu Val Asp Trp 565 570 575 Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu Leu Ile Tyr Tyr Ala 580 585 590 Ser Phe Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Phe 595 600 605 Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu His Pro Glu Asp Phe 610 615 620 Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Pro Ala Pro Leu Thr Phe Gly 625 630 635 640 Gln Gly Thr Lys Val Glu Ile Lys Arg Glu Pro Lys Ser Cys Asp Lys 645 650 655 Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 660 665 670 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 675 680 685 Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 690 695 700 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 705 710 715 720 Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 725 730 735 Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 740 745 750 Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 755 760 765 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 770 775 780 Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 785 790 795 800 Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 805 810 815 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 820 825 830 Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 835 840 845 Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 850 855 860 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 865 870 875 880 Lys <210> 11 <211> 886 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #4 <400> 11 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile 35 40 45 Gly Pro Glu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Thr Ser Ile Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Met Phe 100 105 110 Gln Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Arg Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr 355 360 365 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 370 375 380 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 385 390 395 400 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 405 410 415 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 420 425 430 Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 450 455 460 Ser Gly Gly Gly Gly Ser Met Gln Ile Phe Val Lys Thr Leu Thr Gly 465 470 475 480 Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn Val 485 490 495 Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg 500 505 510 Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp 515 520 525 Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu Arg 530 535 540 Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 545 550 555 560 Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly 565 570 575 Ile Leu Val Asp Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu 580 585 590 Leu Ile Tyr Tyr Ala Ser Phe Leu Gln Ser Gly Val Pro Ser Arg Phe 595 600 605 Ser Gly Ser Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 610 615 620 His Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Pro Ala 625 630 635 640 Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu Pro 645 650 655 Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 660 665 670 Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 675 680 685 Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 690 695 700 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 705 710 715 720 Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 725 730 735 Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 740 745 750 Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 755 760 765 Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 770 775 780 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 785 790 795 800 Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 805 810 815 Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 820 825 830 Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 835 840 845 Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 850 855 860 Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 865 870 875 880 Ser Leu Ser Pro Gly Lys 885 <210> 12 <211> 891 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #5 <400> 12 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile 35 40 45 Gly Pro Glu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Thr Ser Ile Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Met Phe 100 105 110 Gln Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Arg Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr 355 360 365 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 370 375 380 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 385 390 395 400 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 405 410 415 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 420 425 430 Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 450 455 460 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Gln Ile Phe Val 465 470 475 480 Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp 485 490 495 Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro 500 505 510 Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly 515 520 525 Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu 530 535 540 Val Leu Arg Leu Arg Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 545 550 555 560 Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 565 570 575 Ser Gln Trp Ile Gly Ile Leu Val Asp Trp Tyr Gln Gln Lys Pro Gly 580 585 590 Glu Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Phe Leu Gln Ser Gly 595 600 605 Val Pro Ser Arg Phe Ser Gly Ser Gly Phe Gly Thr Asp Phe Thr Leu 610 615 620 Thr Ile Ser Ser Leu His Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 625 630 635 640 Gln Ala Asn Pro Ala Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu 645 650 655 Ile Lys Arg Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 660 665 670 Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 675 680 685 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 690 695 700 Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 705 710 715 720 Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 725 730 735 Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 740 745 750 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 755 760 765 Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 770 775 780 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 785 790 795 800 Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 805 810 815 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 820 825 830 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 835 840 845 Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 850 855 860 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 865 870 875 880 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 885 890 <210> 13 <211> 896 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #6 <400> 13 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile 35 40 45 Gly Pro Glu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Thr Ser Ile Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Met Phe 100 105 110 Gln Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Arg Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr 355 360 365 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 370 375 380 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 385 390 395 400 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 405 410 415 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 420 425 430 Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 450 455 460 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 465 470 475 480 Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 485 490 495 Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 500 505 510 Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys 515 520 525 Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 530 535 540 Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly Asp Ile Gln Met 545 550 555 560 Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 565 570 575 Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Ile Leu Val Asp Trp Tyr 580 585 590 Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser 595 600 605 Phe Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Phe Gly 610 615 620 Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu His Pro Glu Asp Phe Ala 625 630 635 640 Thr Tyr Tyr Cys Gln Gln Ala Asn Pro Ala Pro Leu Thr Phe Gly Gln 645 650 655 Gly Thr Lys Val Glu Ile Lys Arg Glu Pro Lys Ser Cys Asp Lys Thr 660 665 670 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 675 680 685 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 690 695 700 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 705 710 715 720 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 725 730 735 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 740 745 750 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 755 760 765 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 770 775 780 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 785 790 795 800 Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 805 810 815 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 820 825 830 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 835 840 845 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 850 855 860 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 865 870 875 880 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 885 890 895 <210> 14 <211> 901 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #7 <400> 14 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile 35 40 45 Gly Pro Glu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Thr Ser Ile Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Met Phe 100 105 110 Gln Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Arg Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr 355 360 365 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 370 375 380 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 385 390 395 400 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 405 410 415 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 420 425 430 Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 450 455 460 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 465 470 475 480 Gly Gly Gly Gly Ser Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys 485 490 495 Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys 500 505 510 Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu 515 520 525 Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr 530 535 540 Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly 545 550 555 560 Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 565 570 575 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Ile 580 585 590 Leu Val Asp Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu Leu 595 600 605 Ile Tyr Tyr Ala Ser Phe Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 610 615 620 Gly Ser Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu His 625 630 635 640 Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Pro Ala Pro 645 650 655 Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu Pro Lys 660 665 670 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 675 680 685 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 690 695 700 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 705 710 715 720 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 725 730 735 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 740 745 750 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 755 760 765 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 770 775 780 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 785 790 795 800 Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 805 810 815 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 820 825 830 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 835 840 845 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 850 855 860 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 865 870 875 880 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 885 890 895 Leu Ser Pro Gly Lys 900 <210> 15 <211> 871 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #8 <400> 15 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile 35 40 45 Gly Pro Glu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Thr Ser Ile Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Met Phe 100 105 110 Gln Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Arg Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr 355 360 365 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 370 375 380 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 385 390 395 400 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 405 410 415 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 420 425 430 Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Met Gln Ile Phe Val Lys Thr Leu Thr 450 455 460 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 465 470 475 480 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 485 490 495 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 500 505 510 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 515 520 525 Arg Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala 530 535 540 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile 545 550 555 560 Gly Asn Leu Leu Asp Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys 565 570 575 Leu Leu Ile Tyr Tyr Ala Ser Phe Leu Gln Ser Gly Val Pro Ser Arg 580 585 590 Phe Ser Gly Gly Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 595 600 605 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Pro 610 615 620 Ala Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu 625 630 635 640 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 645 650 655 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 660 665 670 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 675 680 685 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 690 695 700 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 705 710 715 720 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 725 730 735 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 740 745 750 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 755 760 765 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 770 775 780 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 785 790 795 800 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 805 810 815 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 820 825 830 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 835 840 845 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 850 855 860 Leu Ser Leu Ser Pro Gly Lys 865 870 <210> 16 <211> 876 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #9 <400> 16 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile 35 40 45 Gly Pro Glu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Thr Ser Ile Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Met Phe 100 105 110 Gln Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Arg Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr 355 360 365 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 370 375 380 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 385 390 395 400 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 405 410 415 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 420 425 430 Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Gln Ile Phe 450 455 460 Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser 465 470 475 480 Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile 485 490 495 Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp 500 505 510 Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His 515 520 525 Leu Val Leu Arg Leu Arg Gly Gly Asp Ile Gln Met Thr Gln Ser Pro 530 535 540 Thr Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 545 550 555 560 Ala Ser Gln Trp Ile Gly Asn Leu Leu Asp Trp Tyr Gln Gln Lys Pro 565 570 575 Gly Glu Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Phe Leu Gln Ser 580 585 590 Gly Val Pro Ser Arg Phe Ser Gly Gly Gly Phe Gly Thr Asp Phe Thr 595 600 605 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 610 615 620 Gln Gln Ala Asn Pro Ala Pro Leu Thr Phe Gly Gln Gly Thr Lys Val 625 630 635 640 Glu Ile Lys Arg Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 645 650 655 Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 660 665 670 Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 675 680 685 Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 690 695 700 Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 705 710 715 720 Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 725 730 735 Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 740 745 750 Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 755 760 765 Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 770 775 780 Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 785 790 795 800 Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 805 810 815 Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 820 825 830 Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 835 840 845 Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 850 855 860 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 865 870 875 <210> 17 <211> 881 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #10 <400> 17 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile 35 40 45 Gly Pro Glu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Thr Ser Ile Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Met Phe 100 105 110 Gln Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Arg Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr 355 360 365 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 370 375 380 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 385 390 395 400 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 405 410 415 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 420 425 430 Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 450 455 460 Ser Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu 465 470 475 480 Glu Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln 485 490 495 Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly 500 505 510 Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys 515 520 525 Glu Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly Asp Ile Gln 530 535 540 Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly Asp Arg Val 545 550 555 560 Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Asn Leu Leu Asp Trp 565 570 575 Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu Leu Ile Tyr Tyr Ala 580 585 590 Ser Phe Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Gly Gly Phe 595 600 605 Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 610 615 620 Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Pro Ala Pro Leu Thr Phe Gly 625 630 635 640 Gln Gly Thr Lys Val Glu Ile Lys Arg Glu Pro Lys Ser Cys Asp Lys 645 650 655 Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 660 665 670 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 675 680 685 Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 690 695 700 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 705 710 715 720 Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 725 730 735 Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 740 745 750 Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 755 760 765 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 770 775 780 Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 785 790 795 800 Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 805 810 815 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 820 825 830 Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 835 840 845 Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 850 855 860 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 865 870 875 880 Lys <210> 18 <211> 886 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #11 <400> 18 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile 35 40 45 Gly Pro Glu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Thr Ser Ile Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Met Phe 100 105 110 Gln Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Arg Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr 355 360 365 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 370 375 380 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 385 390 395 400 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 405 410 415 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 420 425 430 Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 450 455 460 Ser Gly Gly Gly Gly Ser Met Gln Ile Phe Val Lys Thr Leu Thr Gly 465 470 475 480 Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn Val 485 490 495 Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg 500 505 510 Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp 515 520 525 Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu Arg 530 535 540 Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser 545 550 555 560 Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly 565 570 575 Asn Leu Leu Asp Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu 580 585 590 Leu Ile Tyr Tyr Ala Ser Phe Leu Gln Ser Gly Val Pro Ser Arg Phe 595 600 605 Ser Gly Gly Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 610 615 620 Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Pro Ala 625 630 635 640 Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu Pro 645 650 655 Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 660 665 670 Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 675 680 685 Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 690 695 700 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 705 710 715 720 Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 725 730 735 Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 740 745 750 Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 755 760 765 Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 770 775 780 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 785 790 795 800 Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 805 810 815 Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 820 825 830 Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 835 840 845 Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 850 855 860 Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 865 870 875 880 Ser Leu Ser Pro Gly Lys 885 <210> 19 <211> 891 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #12 <400> 19 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile 35 40 45 Gly Pro Glu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Thr Ser Ile Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Met Phe 100 105 110 Gln Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Arg Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr 355 360 365 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 370 375 380 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 385 390 395 400 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 405 410 415 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 420 425 430 Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 450 455 460 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Gln Ile Phe Val 465 470 475 480 Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp 485 490 495 Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro 500 505 510 Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly 515 520 525 Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu 530 535 540 Val Leu Arg Leu Arg Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Thr 545 550 555 560 Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 565 570 575 Ser Gln Trp Ile Gly Asn Leu Leu Asp Trp Tyr Gln Gln Lys Pro Gly 580 585 590 Glu Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Phe Leu Gln Ser Gly 595 600 605 Val Pro Ser Arg Phe Ser Gly Gly Gly Phe Gly Thr Asp Phe Thr Leu 610 615 620 Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 625 630 635 640 Gln Ala Asn Pro Ala Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu 645 650 655 Ile Lys Arg Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 660 665 670 Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 675 680 685 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 690 695 700 Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 705 710 715 720 Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 725 730 735 Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 740 745 750 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 755 760 765 Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 770 775 780 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 785 790 795 800 Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 805 810 815 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 820 825 830 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 835 840 845 Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 850 855 860 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 865 870 875 880 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 885 890 <210> 20 <211> 896 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #13 <400> 20 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile 35 40 45 Gly Pro Glu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Thr Ser Ile Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Met Phe 100 105 110 Gln Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Arg Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr 355 360 365 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 370 375 380 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 385 390 395 400 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 405 410 415 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 420 425 430 Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 450 455 460 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 465 470 475 480 Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 485 490 495 Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 500 505 510 Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys 515 520 525 Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 530 535 540 Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly Asp Ile Gln Met 545 550 555 560 Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 565 570 575 Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Asn Leu Leu Asp Trp Tyr 580 585 590 Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser 595 600 605 Phe Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Gly Gly Phe Gly 610 615 620 Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 625 630 635 640 Thr Tyr Tyr Cys Gln Gln Ala Asn Pro Ala Pro Leu Thr Phe Gly Gln 645 650 655 Gly Thr Lys Val Glu Ile Lys Arg Glu Pro Lys Ser Cys Asp Lys Thr 660 665 670 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 675 680 685 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 690 695 700 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 705 710 715 720 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 725 730 735 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 740 745 750 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 755 760 765 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 770 775 780 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 785 790 795 800 Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 805 810 815 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 820 825 830 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 835 840 845 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 850 855 860 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 865 870 875 880 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 885 890 895 <210> 21 <211> 901 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #14 <400> 21 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile 35 40 45 Gly Pro Glu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Thr Ser Ile Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Met Phe 100 105 110 Gln Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Arg Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr 355 360 365 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 370 375 380 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 385 390 395 400 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 405 410 415 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 420 425 430 Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 450 455 460 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 465 470 475 480 Gly Gly Gly Gly Ser Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys 485 490 495 Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys 500 505 510 Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu 515 520 525 Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr 530 535 540 Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly 545 550 555 560 Gly Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val 565 570 575 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Asn 580 585 590 Leu Leu Asp Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu Leu 595 600 605 Ile Tyr Tyr Ala Ser Phe Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 610 615 620 Gly Gly Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 625 630 635 640 Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Pro Ala Pro 645 650 655 Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu Pro Lys 660 665 670 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 675 680 685 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 690 695 700 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 705 710 715 720 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 725 730 735 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 740 745 750 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 755 760 765 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 770 775 780 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 785 790 795 800 Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 805 810 815 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 820 825 830 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 835 840 845 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 850 855 860 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 865 870 875 880 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 885 890 895 Leu Ser Pro Gly Lys 900 <210> 22 <211> 871 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #15 <400> 22 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Lys Ile 35 40 45 Phe Asn Gly Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Ser Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu Leu 100 105 110 Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr 355 360 365 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 370 375 380 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 385 390 395 400 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 405 410 415 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 420 425 430 Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Met Gln Ile Phe Val Lys Thr Leu Thr 450 455 460 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 465 470 475 480 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 485 490 495 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 500 505 510 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 515 520 525 Arg Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 530 535 540 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile 545 550 555 560 Gly Ile Leu Val Asp Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys 565 570 575 Leu Leu Ile Tyr Tyr Ala Ser Phe Leu Gln Ser Gly Val Pro Ser Arg 580 585 590 Phe Ser Gly Ser Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 595 600 605 Leu His Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Pro 610 615 620 Ala Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu 625 630 635 640 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 645 650 655 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 660 665 670 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 675 680 685 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 690 695 700 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 705 710 715 720 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 725 730 735 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 740 745 750 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 755 760 765 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 770 775 780 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 785 790 795 800 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 805 810 815 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 820 825 830 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 835 840 845 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 850 855 860 Leu Ser Leu Ser Pro Gly Lys 865 870 <210> 23 <211> 876 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #16 <400> 23 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Lys Ile 35 40 45 Phe Asn Gly Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Ser Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu Leu 100 105 110 Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr 355 360 365 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 370 375 380 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 385 390 395 400 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 405 410 415 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 420 425 430 Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Gln Ile Phe 450 455 460 Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser 465 470 475 480 Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile 485 490 495 Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp 500 505 510 Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His 515 520 525 Leu Val Leu Arg Leu Arg Gly Gly Asp Ile Gln Met Thr Gln Ser Pro 530 535 540 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 545 550 555 560 Ala Ser Gln Trp Ile Gly Ile Leu Val Asp Trp Tyr Gln Gln Lys Pro 565 570 575 Gly Glu Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Phe Leu Gln Ser 580 585 590 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Phe Gly Thr Asp Phe Thr 595 600 605 Leu Thr Ile Ser Ser Leu His Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 610 615 620 Gln Gln Ala Asn Pro Ala Pro Leu Thr Phe Gly Gln Gly Thr Lys Val 625 630 635 640 Glu Ile Lys Arg Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 645 650 655 Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 660 665 670 Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 675 680 685 Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 690 695 700 Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 705 710 715 720 Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 725 730 735 Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 740 745 750 Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 755 760 765 Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 770 775 780 Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 785 790 795 800 Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 805 810 815 Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 820 825 830 Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 835 840 845 Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 850 855 860 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 865 870 875 <210> 24 <211> 881 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #17 <400> 24 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Lys Ile 35 40 45 Phe Asn Gly Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Ser Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu Leu 100 105 110 Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr 355 360 365 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 370 375 380 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 385 390 395 400 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 405 410 415 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 420 425 430 Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 450 455 460 Ser Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu 465 470 475 480 Glu Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln 485 490 495 Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly 500 505 510 Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys 515 520 525 Glu Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly Asp Ile Gln 530 535 540 Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 545 550 555 560 Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Ile Leu Val Asp Trp 565 570 575 Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu Leu Ile Tyr Tyr Ala 580 585 590 Ser Phe Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Phe 595 600 605 Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu His Pro Glu Asp Phe 610 615 620 Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Pro Ala Pro Leu Thr Phe Gly 625 630 635 640 Gln Gly Thr Lys Val Glu Ile Lys Arg Glu Pro Lys Ser Cys Asp Lys 645 650 655 Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 660 665 670 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 675 680 685 Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 690 695 700 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 705 710 715 720 Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 725 730 735 Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 740 745 750 Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 755 760 765 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 770 775 780 Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 785 790 795 800 Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 805 810 815 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 820 825 830 Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 835 840 845 Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 850 855 860 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 865 870 875 880 Lys <210> 25 <211> 886 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #18 <400> 25 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Lys Ile 35 40 45 Phe Asn Gly Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Ser Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu Leu 100 105 110 Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr 355 360 365 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 370 375 380 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 385 390 395 400 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 405 410 415 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 420 425 430 Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 450 455 460 Ser Gly Gly Gly Gly Ser Met Gln Ile Phe Val Lys Thr Leu Thr Gly 465 470 475 480 Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn Val 485 490 495 Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg 500 505 510 Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp 515 520 525 Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu Arg 530 535 540 Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 545 550 555 560 Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly 565 570 575 Ile Leu Val Asp Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu 580 585 590 Leu Ile Tyr Tyr Ala Ser Phe Leu Gln Ser Gly Val Pro Ser Arg Phe 595 600 605 Ser Gly Ser Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 610 615 620 His Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Pro Ala 625 630 635 640 Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu Pro 645 650 655 Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 660 665 670 Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 675 680 685 Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 690 695 700 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 705 710 715 720 Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 725 730 735 Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 740 745 750 Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 755 760 765 Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 770 775 780 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 785 790 795 800 Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 805 810 815 Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 820 825 830 Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 835 840 845 Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 850 855 860 Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 865 870 875 880 Ser Leu Ser Pro Gly Lys 885 <210> 26 <211> 891 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #19 <400> 26 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Lys Ile 35 40 45 Phe Asn Gly Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Ser Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu Leu 100 105 110 Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr 355 360 365 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 370 375 380 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 385 390 395 400 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 405 410 415 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 420 425 430 Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 450 455 460 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Gln Ile Phe Val 465 470 475 480 Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp 485 490 495 Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro 500 505 510 Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly 515 520 525 Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu 530 535 540 Val Leu Arg Leu Arg Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 545 550 555 560 Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 565 570 575 Ser Gln Trp Ile Gly Ile Leu Val Asp Trp Tyr Gln Gln Lys Pro Gly 580 585 590 Glu Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Phe Leu Gln Ser Gly 595 600 605 Val Pro Ser Arg Phe Ser Gly Ser Gly Phe Gly Thr Asp Phe Thr Leu 610 615 620 Thr Ile Ser Ser Leu His Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 625 630 635 640 Gln Ala Asn Pro Ala Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu 645 650 655 Ile Lys Arg Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 660 665 670 Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 675 680 685 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 690 695 700 Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 705 710 715 720 Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 725 730 735 Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 740 745 750 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 755 760 765 Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 770 775 780 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 785 790 795 800 Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 805 810 815 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 820 825 830 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 835 840 845 Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 850 855 860 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 865 870 875 880 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 885 890 <210> 27 <211> 896 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #20 <400> 27 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Lys Ile 35 40 45 Phe Asn Gly Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Ser Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu Leu 100 105 110 Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr 355 360 365 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 370 375 380 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 385 390 395 400 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 405 410 415 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 420 425 430 Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 450 455 460 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 465 470 475 480 Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 485 490 495 Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 500 505 510 Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys 515 520 525 Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 530 535 540 Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly Asp Ile Gln Met 545 550 555 560 Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 565 570 575 Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Ile Leu Val Asp Trp Tyr 580 585 590 Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser 595 600 605 Phe Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Phe Gly 610 615 620 Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu His Pro Glu Asp Phe Ala 625 630 635 640 Thr Tyr Tyr Cys Gln Gln Ala Asn Pro Ala Pro Leu Thr Phe Gly Gln 645 650 655 Gly Thr Lys Val Glu Ile Lys Arg Glu Pro Lys Ser Cys Asp Lys Thr 660 665 670 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 675 680 685 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 690 695 700 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 705 710 715 720 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 725 730 735 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 740 745 750 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 755 760 765 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 770 775 780 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 785 790 795 800 Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 805 810 815 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 820 825 830 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 835 840 845 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 850 855 860 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 865 870 875 880 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 885 890 895 <210> 28 <211> 901 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #21 <400> 28 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Lys Ile 35 40 45 Phe Asn Gly Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Ser Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu Leu 100 105 110 Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr 355 360 365 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 370 375 380 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 385 390 395 400 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 405 410 415 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 420 425 430 Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 450 455 460 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 465 470 475 480 Gly Gly Gly Gly Ser Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys 485 490 495 Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys 500 505 510 Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu 515 520 525 Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr 530 535 540 Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly 545 550 555 560 Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 565 570 575 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Ile 580 585 590 Leu Val Asp Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu Leu 595 600 605 Ile Tyr Tyr Ala Ser Phe Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 610 615 620 Gly Ser Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu His 625 630 635 640 Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Pro Ala Pro 645 650 655 Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu Pro Lys 660 665 670 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 675 680 685 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 690 695 700 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 705 710 715 720 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 725 730 735 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 740 745 750 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 755 760 765 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 770 775 780 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 785 790 795 800 Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 805 810 815 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 820 825 830 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 835 840 845 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 850 855 860 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 865 870 875 880 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 885 890 895 Leu Ser Pro Gly Lys 900 <210> 29 <211> 871 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #22 <400> 29 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Lys Ile 35 40 45 Phe Asn Gly Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Ser Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu Leu 100 105 110 Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr 355 360 365 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 370 375 380 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 385 390 395 400 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 405 410 415 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 420 425 430 Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Met Gln Ile Phe Val Lys Thr Leu Thr 450 455 460 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 465 470 475 480 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 485 490 495 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 500 505 510 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 515 520 525 Arg Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala 530 535 540 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile 545 550 555 560 Gly Asn Leu Leu Asp Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys 565 570 575 Leu Leu Ile Tyr Tyr Ala Ser Phe Leu Gln Ser Gly Val Pro Ser Arg 580 585 590 Phe Ser Gly Gly Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 595 600 605 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Pro 610 615 620 Ala Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu 625 630 635 640 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 645 650 655 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 660 665 670 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 675 680 685 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 690 695 700 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 705 710 715 720 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 725 730 735 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 740 745 750 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 755 760 765 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 770 775 780 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 785 790 795 800 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 805 810 815 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 820 825 830 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 835 840 845 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 850 855 860 Leu Ser Leu Ser Pro Gly Lys 865 870 <210> 30 <211> 876 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #23 <400> 30 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Lys Ile 35 40 45 Phe Asn Gly Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Ser Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu Leu 100 105 110 Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr 355 360 365 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 370 375 380 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 385 390 395 400 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 405 410 415 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 420 425 430 Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Gln Ile Phe 450 455 460 Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser 465 470 475 480 Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile 485 490 495 Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp 500 505 510 Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His 515 520 525 Leu Val Leu Arg Leu Arg Gly Gly Asp Ile Gln Met Thr Gln Ser Pro 530 535 540 Thr Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 545 550 555 560 Ala Ser Gln Trp Ile Gly Asn Leu Leu Asp Trp Tyr Gln Gln Lys Pro 565 570 575 Gly Glu Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Phe Leu Gln Ser 580 585 590 Gly Val Pro Ser Arg Phe Ser Gly Gly Gly Phe Gly Thr Asp Phe Thr 595 600 605 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 610 615 620 Gln Gln Ala Asn Pro Ala Pro Leu Thr Phe Gly Gln Gly Thr Lys Val 625 630 635 640 Glu Ile Lys Arg Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 645 650 655 Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 660 665 670 Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 675 680 685 Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 690 695 700 Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 705 710 715 720 Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 725 730 735 Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 740 745 750 Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 755 760 765 Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 770 775 780 Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 785 790 795 800 Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 805 810 815 Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 820 825 830 Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 835 840 845 Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 850 855 860 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 865 870 875 <210> 31 <211> 881 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #24 <400> 31 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Lys Ile 35 40 45 Phe Asn Gly Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Ser Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu Leu 100 105 110 Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr 355 360 365 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 370 375 380 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 385 390 395 400 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 405 410 415 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 420 425 430 Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 450 455 460 Ser Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu 465 470 475 480 Glu Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln 485 490 495 Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly 500 505 510 Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys 515 520 525 Glu Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly Asp Ile Gln 530 535 540 Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly Asp Arg Val 545 550 555 560 Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Asn Leu Leu Asp Trp 565 570 575 Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu Leu Ile Tyr Tyr Ala 580 585 590 Ser Phe Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Gly Gly Phe 595 600 605 Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 610 615 620 Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Pro Ala Pro Leu Thr Phe Gly 625 630 635 640 Gln Gly Thr Lys Val Glu Ile Lys Arg Glu Pro Lys Ser Cys Asp Lys 645 650 655 Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 660 665 670 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 675 680 685 Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 690 695 700 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 705 710 715 720 Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 725 730 735 Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 740 745 750 Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 755 760 765 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 770 775 780 Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 785 790 795 800 Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 805 810 815 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 820 825 830 Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 835 840 845 Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 850 855 860 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 865 870 875 880 Lys <210> 32 <211> 886 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #25 <400> 32 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Lys Ile 35 40 45 Phe Asn Gly Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Ser Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu Leu 100 105 110 Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr 355 360 365 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 370 375 380 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 385 390 395 400 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 405 410 415 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 420 425 430 Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 450 455 460 Ser Gly Gly Gly Gly Ser Met Gln Ile Phe Val Lys Thr Leu Thr Gly 465 470 475 480 Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn Val 485 490 495 Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg 500 505 510 Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp 515 520 525 Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu Arg 530 535 540 Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser 545 550 555 560 Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly 565 570 575 Asn Leu Leu Asp Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu 580 585 590 Leu Ile Tyr Tyr Ala Ser Phe Leu Gln Ser Gly Val Pro Ser Arg Phe 595 600 605 Ser Gly Gly Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 610 615 620 Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Pro Ala 625 630 635 640 Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu Pro 645 650 655 Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 660 665 670 Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 675 680 685 Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 690 695 700 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 705 710 715 720 Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 725 730 735 Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 740 745 750 Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 755 760 765 Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 770 775 780 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 785 790 795 800 Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 805 810 815 Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 820 825 830 Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 835 840 845 Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 850 855 860 Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 865 870 875 880 Ser Leu Ser Pro Gly Lys 885 <210> 33 <211> 891 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #26 <400> 33 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Lys Ile 35 40 45 Phe Asn Gly Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Ser Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu Leu 100 105 110 Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr 355 360 365 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 370 375 380 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 385 390 395 400 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 405 410 415 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 420 425 430 Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 450 455 460 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Gln Ile Phe Val 465 470 475 480 Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp 485 490 495 Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro 500 505 510 Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly 515 520 525 Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu 530 535 540 Val Leu Arg Leu Arg Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Thr 545 550 555 560 Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 565 570 575 Ser Gln Trp Ile Gly Asn Leu Leu Asp Trp Tyr Gln Gln Lys Pro Gly 580 585 590 Glu Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Phe Leu Gln Ser Gly 595 600 605 Val Pro Ser Arg Phe Ser Gly Gly Gly Phe Gly Thr Asp Phe Thr Leu 610 615 620 Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 625 630 635 640 Gln Ala Asn Pro Ala Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu 645 650 655 Ile Lys Arg Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 660 665 670 Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 675 680 685 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 690 695 700 Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 705 710 715 720 Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 725 730 735 Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 740 745 750 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 755 760 765 Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 770 775 780 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 785 790 795 800 Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 805 810 815 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 820 825 830 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 835 840 845 Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 850 855 860 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 865 870 875 880 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 885 890 <210> 34 <211> 896 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #27 <400> 34 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Lys Ile 35 40 45 Phe Asn Gly Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Ser Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu Leu 100 105 110 Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr 355 360 365 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 370 375 380 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 385 390 395 400 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 405 410 415 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 420 425 430 Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 450 455 460 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 465 470 475 480 Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 485 490 495 Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 500 505 510 Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys 515 520 525 Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 530 535 540 Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly Asp Ile Gln Met 545 550 555 560 Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 565 570 575 Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Asn Leu Leu Asp Trp Tyr 580 585 590 Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser 595 600 605 Phe Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Gly Gly Phe Gly 610 615 620 Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 625 630 635 640 Thr Tyr Tyr Cys Gln Gln Ala Asn Pro Ala Pro Leu Thr Phe Gly Gln 645 650 655 Gly Thr Lys Val Glu Ile Lys Arg Glu Pro Lys Ser Cys Asp Lys Thr 660 665 670 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 675 680 685 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 690 695 700 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 705 710 715 720 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 725 730 735 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 740 745 750 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 755 760 765 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 770 775 780 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 785 790 795 800 Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 805 810 815 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 820 825 830 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 835 840 845 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 850 855 860 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 865 870 875 880 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 885 890 895 <210> 35 <211> 901 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #28 <400> 35 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Lys Ile 35 40 45 Phe Asn Gly Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Ser Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu Leu 100 105 110 Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr 355 360 365 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 370 375 380 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 385 390 395 400 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 405 410 415 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 420 425 430 Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 450 455 460 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 465 470 475 480 Gly Gly Gly Gly Ser Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys 485 490 495 Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys 500 505 510 Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu 515 520 525 Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr 530 535 540 Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly 545 550 555 560 Gly Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val 565 570 575 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Asn 580 585 590 Leu Leu Asp Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu Leu 595 600 605 Ile Tyr Tyr Ala Ser Phe Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 610 615 620 Gly Gly Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 625 630 635 640 Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Pro Ala Pro 645 650 655 Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu Pro Lys 660 665 670 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 675 680 685 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 690 695 700 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 705 710 715 720 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 725 730 735 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 740 745 750 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 755 760 765 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 770 775 780 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 785 790 795 800 Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 805 810 815 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 820 825 830 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 835 840 845 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 850 855 860 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 865 870 875 880 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 885 890 895 Leu Ser Pro Gly Lys 900 <210> 36 <211> 880 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #29 <400> 36 Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly Val 1 5 10 15 His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 20 25 30 Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Lys Ile Phe 35 40 45 Asn Gly Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 50 55 60 Leu Ile Tyr His Ser Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe 65 70 75 80 Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 85 90 95 Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu Leu Tyr 100 105 110 Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu Pro 115 120 125 Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 130 135 140 Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 145 150 155 160 Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 165 170 175 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 180 185 190 Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 195 200 205 Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 210 215 220 Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 225 230 235 240 Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 245 250 255 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 260 265 270 Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 275 280 285 Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 290 295 300 Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 305 310 315 320 Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 325 330 335 Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 340 345 350 Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr Gly 355 360 365 Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn Val 370 375 380 Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg 385 390 395 400 Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp 405 410 415 Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu Arg 420 425 430 Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 435 440 445 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 450 455 460 Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 465 470 475 480 Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 485 490 495 Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys 500 505 510 Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 515 520 525 Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly Asp Ile Gln Met 530 535 540 Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 545 550 555 560 Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Asn Leu Leu Asp Trp Tyr 565 570 575 Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser 580 585 590 Phe Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Gly Gly Phe Gly 595 600 605 Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 610 615 620 Thr Tyr Tyr Cys Gln Gln Ala Asn Pro Ala Pro Leu Thr Phe Gly Gln 625 630 635 640 Gly Thr Lys Val Glu Ile Lys Arg Glu Pro Lys Ser Cys Asp Lys Thr 645 650 655 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 660 665 670 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 675 680 685 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 690 695 700 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 705 710 715 720 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 725 730 735 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 740 745 750 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 755 760 765 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 770 775 780 Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 785 790 795 800 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 805 810 815 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 820 825 830 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 835 840 845 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 850 855 860 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 865 870 875 880 <210> 37 <211> 777 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #30 <400> 37 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Lys Ile 35 40 45 Phe Asn Gly Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Ser Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu Leu 100 105 110 Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr 355 360 365 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 370 375 380 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 385 390 395 400 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 405 410 415 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 420 425 430 Arg Gly Gly Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu 435 440 445 Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 450 455 460 Trp Ile Gly Asn Leu Leu Asp Trp Tyr Gln Gln Lys Pro Gly Glu Ala 465 470 475 480 Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Phe Leu Gln Ser Gly Val Pro 485 490 495 Ser Arg Phe Ser Gly Gly Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile 500 505 510 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala 515 520 525 Asn Pro Ala Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 530 535 540 Arg Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 545 550 555 560 Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 565 570 575 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 580 585 590 Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 595 600 605 Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 610 615 620 Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 625 630 635 640 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 645 650 655 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 660 665 670 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 675 680 685 Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 690 695 700 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 705 710 715 720 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 725 730 735 Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 740 745 750 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 755 760 765 Lys Ser Leu Ser Leu Ser Pro Gly Lys 770 775 <210> 38 <211> 886 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #31 <400> 38 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Lys Ile 35 40 45 Phe Asn Gly Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Ser Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu Leu 100 105 110 Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr 355 360 365 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 370 375 380 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 385 390 395 400 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 405 410 415 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 420 425 430 Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 450 455 460 Ser Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu 465 470 475 480 Glu Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln 485 490 495 Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly 500 505 510 Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys 515 520 525 Glu Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly Gly Gly Gly 530 535 540 Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser 545 550 555 560 Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly 565 570 575 Asn Leu Leu Asp Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu 580 585 590 Leu Ile Tyr Tyr Ala Ser Phe Leu Gln Ser Gly Val Pro Ser Arg Phe 595 600 605 Ser Gly Gly Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 610 615 620 Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Pro Ala 625 630 635 640 Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu Pro 645 650 655 Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 660 665 670 Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 675 680 685 Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 690 695 700 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 705 710 715 720 Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 725 730 735 Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 740 745 750 Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 755 760 765 Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 770 775 780 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 785 790 795 800 Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 805 810 815 Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 820 825 830 Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 835 840 845 Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 850 855 860 Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 865 870 875 880 Ser Leu Ser Pro Gly Lys 885 <210> 39 <211> 883 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #32 <400> 39 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Lys Ile 35 40 45 Phe Asn Gly Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Ser Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu Leu 100 105 110 Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr 355 360 365 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 370 375 380 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 385 390 395 400 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 405 410 415 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 420 425 430 Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 450 455 460 Ser Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu 465 470 475 480 Glu Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln 485 490 495 Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly 500 505 510 Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys 515 520 525 Glu Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly Gly Gly Asp 530 535 540 Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly Asp 545 550 555 560 Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Asn Leu Leu 565 570 575 Asp Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu Leu Ile Tyr 580 585 590 Tyr Ala Ser Phe Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Gly 595 600 605 Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 610 615 620 Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Pro Ala Pro Leu Thr 625 630 635 640 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu Pro Lys Ser Cys 645 650 655 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 660 665 670 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 675 680 685 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 690 695 700 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 705 710 715 720 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 725 730 735 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 740 745 750 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 755 760 765 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 770 775 780 Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 785 790 795 800 Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 805 810 815 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 820 825 830 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 835 840 845 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 850 855 860 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 865 870 875 880 Pro Gly Lys <210> 40 <211> 886 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #33 <400> 40 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Lys Ile 35 40 45 Phe Asn Gly Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Ser Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu Leu 100 105 110 Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr 355 360 365 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 370 375 380 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 385 390 395 400 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 405 410 415 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 420 425 430 Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 450 455 460 Ser Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu 465 470 475 480 Glu Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln 485 490 495 Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly 500 505 510 Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys 515 520 525 Glu Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly Gly Gly Gly 530 535 540 Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser 545 550 555 560 Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly 565 570 575 Asn Leu Leu Asp Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu 580 585 590 Leu Ile Tyr Tyr Ala Ser Phe Leu Gln Ser Gly Val Pro Ser Arg Phe 595 600 605 Ser Gly Gly Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 610 615 620 Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Pro Ala 625 630 635 640 Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu Pro 645 650 655 Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 660 665 670 Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 675 680 685 Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 690 695 700 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 705 710 715 720 Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 725 730 735 Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 740 745 750 Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 755 760 765 Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 770 775 780 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 785 790 795 800 Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 805 810 815 Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 820 825 830 Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 835 840 845 Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 850 855 860 Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 865 870 875 880 Ser Leu Ser Pro Gly Lys 885 <210> 41 <211> 777 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #34 <400> 41 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Lys Ile 35 40 45 Phe Asn Gly Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Ser Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu Leu 100 105 110 Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr 355 360 365 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 370 375 380 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 385 390 395 400 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 405 410 415 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 420 425 430 Arg Gly Gly Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu 435 440 445 Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 450 455 460 Trp Ile Gly Asn Leu Leu Asp Trp Tyr Gln Gln Lys Pro Gly Glu Ala 465 470 475 480 Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Phe Leu Gln Ser Gly Val Pro 485 490 495 Ser Arg Phe Ser Gly Gly Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile 500 505 510 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala 515 520 525 Asn Pro Ala Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 530 535 540 Arg Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 545 550 555 560 Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 565 570 575 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 580 585 590 Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 595 600 605 Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 610 615 620 Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 625 630 635 640 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 645 650 655 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 660 665 670 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 675 680 685 Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 690 695 700 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 705 710 715 720 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 725 730 735 Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 740 745 750 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 755 760 765 Lys Ser Leu Ser Leu Ser Pro Gly Lys 770 775 <210> 42 <211> 780 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #35 <400> 42 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Lys Ile 35 40 45 Phe Asn Gly Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Ser Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu Leu 100 105 110 Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Met Gln Ile Phe Val Lys Thr Leu Thr 355 360 365 Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn 370 375 380 Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln 385 390 395 400 Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser 405 410 415 Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu 420 425 430 Arg Gly Gly Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 435 440 445 Thr Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 450 455 460 Ala Ser Gln Trp Ile Gly Asn Leu Leu Asp Trp Tyr Gln Gln Lys Pro 465 470 475 480 Gly Glu Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Phe Leu Gln Ser 485 490 495 Gly Val Pro Ser Arg Phe Ser Gly Gly Gly Phe Gly Thr Asp Phe Thr 500 505 510 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 515 520 525 Gln Gln Ala Asn Pro Ala Pro Leu Thr Phe Gly Gln Gly Thr Lys Val 530 535 540 Glu Ile Lys Arg Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 545 550 555 560 Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 565 570 575 Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 580 585 590 Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 595 600 605 Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 610 615 620 Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 625 630 635 640 Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 645 650 655 Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 660 665 670 Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 675 680 685 Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 690 695 700 Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 705 710 715 720 Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 725 730 735 Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 740 745 750 Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 755 760 765 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 770 775 780 <210> 43 <211> 825 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #36 <400> 43 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Lys Ile 35 40 45 Phe Asn Gly Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Ser Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu Leu 100 105 110 Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Gly Gly Met Lys Arg Gln Gly Lys Glu 355 360 365 Met Asp Ser Leu Arg Phe Leu Tyr Asp Gly Ile Arg Ile Gln Ala Asp 370 375 380 Gln Ala Pro Glu Asp Leu Asp Met Glu Asp Asn Asp Ile Ile Glu Ala 385 390 395 400 His Arg Glu Gln Ile Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 405 410 415 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 420 425 430 Gly Gly Gly Gly Ser Met Lys Arg Gln Gly Lys Glu Met Asp Ser Leu 435 440 445 Arg Phe Leu Tyr Asp Gly Ile Arg Ile Gln Ala Asp Gln Ala Pro Glu 450 455 460 Asp Leu Asp Met Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln 465 470 475 480 Ile Gly Gly Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu 485 490 495 Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 500 505 510 Trp Ile Gly Asn Leu Leu Asp Trp Tyr Gln Gln Lys Pro Gly Glu Ala 515 520 525 Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Phe Leu Gln Ser Gly Val Pro 530 535 540 Ser Arg Phe Ser Gly Gly Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile 545 550 555 560 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala 565 570 575 Asn Pro Ala Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 580 585 590 Arg Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 595 600 605 Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 610 615 620 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 625 630 635 640 Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 645 650 655 Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 660 665 670 Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 675 680 685 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 690 695 700 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 705 710 715 720 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 725 730 735 Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 740 745 750 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 755 760 765 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 770 775 780 Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 785 790 795 800 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 805 810 815 Lys Ser Leu Ser Leu Ser Pro Gly Lys 820 825 <210> 44 <211> 753 <212> PRT <213> Artificial Sequence <220> <223> Protein complex comprising VEGF and EGFR specific binding peptides #37 <400> 44 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 20 25 30 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Lys Ile 35 40 45 Phe Asn Gly Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 50 55 60 Leu Leu Ile Tyr His Ser Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 85 90 95 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu Leu 100 105 110 Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Glu 115 120 125 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 130 135 140 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 145 150 155 160 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 165 170 175 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 180 185 190 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 195 200 205 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 210 215 220 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 225 230 235 240 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 245 250 255 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 260 265 270 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 275 280 285 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 290 295 300 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 305 310 315 320 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 325 330 335 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 340 345 350 Leu Ser Leu Ser Pro Gly Lys Asp Tyr Asp Ile Pro Thr Thr Glu Asn 355 360 365 Leu Tyr Phe Gln Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 370 375 380 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 385 390 395 400 Gly Gly Ser Glu Asn Leu Tyr Phe Gln Gly Ser Gly Gly Asp Ile Gln 405 410 415 Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly Asp Arg Val 420 425 430 Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Asn Leu Leu Asp Trp 435 440 445 Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu Leu Ile Tyr Tyr Ala 450 455 460 Ser Phe Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Gly Gly Phe 465 470 475 480 Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 485 490 495 Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Pro Ala Pro Leu Thr Phe Gly 500 505 510 Gln Gly Thr Lys Val Glu Ile Lys Arg Glu Pro Lys Ser Cys Asp Lys 515 520 525 Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 530 535 540 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 545 550 555 560 Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 565 570 575 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 580 585 590 Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 595 600 605 Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 610 615 620 Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 625 630 635 640 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 645 650 655 Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 660 665 670 Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 675 680 685 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 690 695 700 Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 705 710 715 720 Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 725 730 735 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 740 745 750 Lys <210> 45 <211> 2634 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #1 <400> 45 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtag agccagccag tggatcggcc ctgagctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca ccagcatcct gcagagcggc 240 gtgcccagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagt acatgttcca gccccggacc 360 tttggccagg gcaccaaggt ggaaatcaga agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtggtggtt ctggtggcgg aggatctggc ggtggtggat ctgggggagg tggaagtatg 1380 cagatttttg tcaagacact gaccgggaaa acaatcacac tcgaagtcga gccctccgat 1440 acaattgaga atgtgaaagc caaaattcag gacaaagaag ggattcctcc tgatcagcag 1500 cggctgattt ttgccggaaa acagctcgaa gatggacgga ccctgtccga ttacaatatt 1560 cagaaagaaa gcaccctcca tctggtcctg aggctgcggg gaggcgacat tcagatgaca 1620 cagtccccca gctccctgag cgccagcgtg ggagatcgcg tgaccattac atgccgggcc 1680 tcccagtgga ttggcatcct ggtggattgg tatcagcaga aacctgggga ggctcctaaa 1740 ctgctgatct attacgccag ctttctgcag tccggcgtgc cctctagatt cagcggctct 1800 ggcttcggca cagatttcac actgaccatc tctagcctgc accctgaaga ttttgccaca 1860 tattactgtc agcaggccaa ccctgccccc ctgacattcg gccagggaac aaaggtcgag 1920 atcaagcgcg agcccaagtc ctgtgataag acacatacct gccccccctg cccagctcca 1980 gaactgctcg gaggaccttc tgtgtttctg tttccaccca agcctaagga tacactcatg 2040 atctccagaa cacctgaagt gacatgtgtg gtcgtcgacg tgtcacatga ggatccagaa 2100 gtcaagttta actggtatgt ggatggggtc gaggtgcaca atgccaaaac aaaacctcgg 2160 gaagaacagt ataattccac ctatagagtc gtgtctgtgc tcaccgtgct ccatcaggat 2220 tggctcaatg ggaaagaata caaatgtaaa gtctctaaca aagccctgcc cgctcctatc 2280 gaaaagacaa tctccaaggc caaaggacag cctcgcgagc ctcaggtcta caccctgcca 2340 ccttcccgcg aggaaatgac aaaaaatcag gtgtcactca cctgtctcgt gaaggggttt 2400 tacccctccg acattgccgt cgagtgggag tccaatggac agcccgagaa caattataag 2460 acaacacctc ccgtcctgga ctccgatgga tcattttttc tgtactccaa gctcaccgtc 2520 gataagtcca gatggcagca gggaaatgtc ttttcctgct ccgtgatgca tgaagctctc 2580 cacaatcatt acacacagaa aagcctgtcc ctgtcccccg gcaagtgact cgag 2634 <210> 46 <211> 2649 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #2 <400> 46 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtag agccagccag tggatcggcc ctgagctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca ccagcatcct gcagagcggc 240 gtgcccagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagt acatgttcca gccccggacc 360 tttggccagg gcaccaaggt ggaaatcaga agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtggtggtt ctggtggcgg aggatctggc ggtggtggat ctgggggagg tggaagtggt 1380 ggcggtggta gtatgcagat ttttgtcaag acactgaccg ggaaaacaat cacactcgaa 1440 gtcgagccct ccgatacaat tgagaatgtg aaagccaaaa ttcaggacaa agaagggatt 1500 cctcctgatc agcagcggct gatttttgcc ggaaaacagc tcgaagatgg acggaccctg 1560 tccgattaca atattcagaa agaaagcacc ctccatctgg tcctgaggct gcggggaggc 1620 gacattcaga tgacacagtc ccccagctcc ctgagcgcca gcgtgggaga tcgcgtgacc 1680 attacatgcc gggcctccca gtggattggc atcctggtgg attggtatca gcagaaacct 1740 ggggaggctc ctaaactgct gatctattac gccagctttc tgcagtccgg cgtgccctct 1800 agattcagcg gctctggctt cggcacagat ttcacactga ccatctctag cctgcaccct 1860 gaagattttg ccacatatta ctgtcagcag gccaaccctg cccccctgac attcggccag 1920 ggaacaaagg tcgagatcaa gcgcgagccc aagtcctgtg ataagacaca tacctgcccc 1980 ccctgcccag ctccagaact gctcggagga ccttctgtgt ttctgtttcc acccaagcct 2040 aaggatacac tcatgatctc cagaacacct gaagtgacat gtgtggtcgt cgacgtgtca 2100 catgaggatc cagaagtcaa gtttaactgg tatgtggatg gggtcgaggt gcacaatgcc 2160 aaaacaaaac ctcgggaaga acagtataat tccacctata gagtcgtgtc tgtgctcacc 2220 gtgctccatc aggattggct caatgggaaa gaatacaaat gtaaagtctc taacaaagcc 2280 ctgcccgctc ctatcgaaaa gacaatctcc aaggccaaag gacagcctcg cgagcctcag 2340 gtctacaccc tgccaccttc ccgcgaggaa atgacaaaaa atcaggtgtc actcacctgt 2400 ctcgtgaagg ggttttaccc ctccgacatt gccgtcgagt gggagtccaa tggacagccc 2460 gagaacaatt ataagacaac acctcccgtc ctggactccg atggatcatt ttttctgtac 2520 tccaagctca ccgtcgataa gtccagatgg cagcagggaa atgtcttttc ctgctccgtg 2580 atgcatgaag ctctccacaa tcattacaca cagaaaagcc tgtccctgtc ccccggcaag 2640 tgactcgag 2649 <210> 47 <211> 2664 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #3 <400> 47 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtag agccagccag tggatcggcc ctgagctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca ccagcatcct gcagagcggc 240 gtgcccagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagt acatgttcca gccccggacc 360 tttggccagg gcaccaaggt ggaaatcaga agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtggtggtt ctggtggcgg aggatctggc ggtggtggat ctgggggagg tggaagtggt 1380 ggcggtggta gtggtggtgg cggaagcatg cagatttttg tcaagacact gaccgggaaa 1440 acaatcacac tcgaagtcga gccctccgat acaattgaga atgtgaaagc caaaattcag 1500 gacaaagaag ggattcctcc tgatcagcag cggctgattt ttgccggaaa acagctcgaa 1560 gatggacgga ccctgtccga ttacaatatt cagaaagaaa gcaccctcca tctggtcctg 1620 aggctgcggg gaggcgacat tcagatgaca cagtccccca gctccctgag cgccagcgtg 1680 ggagatcgcg tgaccattac atgccgggcc tcccagtgga ttggcatcct ggtggattgg 1740 tatcagcaga aacctgggga ggctcctaaa ctgctgatct attacgccag ctttctgcag 1800 tccggcgtgc cctctagatt cagcggctct ggcttcggca cagatttcac actgaccatc 1860 tctagcctgc accctgaaga ttttgccaca tattactgtc agcaggccaa ccctgccccc 1920 ctgacattcg gccagggaac aaaggtcgag atcaagcgcg agcccaagtc ctgtgataag 1980 acacatacct gccccccctg cccagctcca gaactgctcg gaggaccttc tgtgtttctg 2040 tttccaccca agcctaagga tacactcatg atctccagaa cacctgaagt gacatgtgtg 2100 gtcgtcgacg tgtcacatga ggatccagaa gtcaagttta actggtatgt ggatggggtc 2160 gaggtgcaca atgccaaaac aaaacctcgg gaagaacagt ataattccac ctatagagtc 2220 gtgtctgtgc tcaccgtgct ccatcaggat tggctcaatg ggaaagaata caaatgtaaa 2280 gtctctaaca aagccctgcc cgctcctatc gaaaagacaa tctccaaggc caaaggacag 2340 cctcgcgagc ctcaggtcta caccctgcca ccttcccgcg aggaaatgac aaaaaatcag 2400 gtgtcactca cctgtctcgt gaaggggttt tacccctccg acattgccgt cgagtgggag 2460 tccaatggac agcccgagaa caattataag acaacacctc ccgtcctgga ctccgatgga 2520 tcattttttc tgtactccaa gctcaccgtc gataagtcca gatggcagca gggaaatgtc 2580 ttttcctgct ccgtgatgca tgaagctctc cacaatcatt acacacagaa aagcctgtcc 2640 ctgtcccccg gcaagtgact cgag 2664 <210> 48 <211> 2679 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #4 <400> 48 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtag agccagccag tggatcggcc ctgagctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca ccagcatcct gcagagcggc 240 gtgcccagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagt acatgttcca gccccggacc 360 tttggccagg gcaccaaggt ggaaatcaga agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtggtggtt ctggtggcgg aggatctggc ggtggtggat ctgggggagg tggaagtggt 1380 ggcggtggta gtggtggtgg cggaagcgga ggcggtggat caatgcagat ttttgtcaag 1440 acactgaccg ggaaaacaat cacactcgaa gtcgagccct ccgatacaat tgagaatgtg 1500 aaagccaaaa ttcaggacaa agaagggatt cctcctgatc agcagcggct gatttttgcc 1560 ggaaaacagc tcgaagatgg acggaccctg tccgattaca atattcagaa agaaagcacc 1620 ctccatctgg tcctgaggct gcggggaggc gacattcaga tgacacagtc ccccagctcc 1680 ctgagcgcca gcgtgggaga tcgcgtgacc attacatgcc gggcctccca gtggattggc 1740 atcctggtgg attggtatca gcagaaacct ggggaggctc ctaaactgct gatctattac 1800 gccagctttc tgcagtccgg cgtgccctct agattcagcg gctctggctt cggcacagat 1860 ttcacactga ccatctctag cctgcaccct gaagattttg ccacatatta ctgtcagcag 1920 gccaaccctg cccccctgac attcggccag ggaacaaagg tcgagatcaa gcgcgagccc 1980 aagtcctgtg ataagacaca tacctgcccc ccctgcccag ctccagaact gctcggagga 2040 ccttctgtgt ttctgtttcc acccaagcct aaggatacac tcatgatctc cagaacacct 2100 gaagtgacat gtgtggtcgt cgacgtgtca catgaggatc cagaagtcaa gtttaactgg 2160 tatgtggatg gggtcgaggt gcacaatgcc aaaacaaaac ctcgggaaga acagtataat 2220 tccacctata gagtcgtgtc tgtgctcacc gtgctccatc aggattggct caatgggaaa 2280 gaatacaaat gtaaagtctc taacaaagcc ctgcccgctc ctatcgaaaa gacaatctcc 2340 aaggccaaag gacagcctcg cgagcctcag gtctacaccc tgccaccttc ccgcgaggaa 2400 atgacaaaaa atcaggtgtc actcacctgt ctcgtgaagg ggttttaccc ctccgacatt 2460 gccgtcgagt gggagtccaa tggacagccc gagaacaatt ataagacaac acctcccgtc 2520 ctggactccg atggatcatt ttttctgtac tccaagctca ccgtcgataa gtccagatgg 2580 cagcagggaa atgtcttttc ctgctccgtg atgcatgaag ctctccacaa tcattacaca 2640 cagaaaagcc tgtccctgtc ccccggcaag tgactcgag 2679 <210> 49 <211> 2694 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #5 <400> 49 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtag agccagccag tggatcggcc ctgagctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca ccagcatcct gcagagcggc 240 gtgcccagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagt acatgttcca gccccggacc 360 tttggccagg gcaccaaggt ggaaatcaga agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtggtggtt ctggtggcgg aggatctggc ggtggtggat ctgggggagg tggaagtggt 1380 ggcggtggta gtggtggtgg cggaagcgga ggcggtggat caggcggagg cggatcaatg 1440 cagatttttg tcaagacact gaccgggaaa acaatcacac tcgaagtcga gccctccgat 1500 acaattgaga atgtgaaagc caaaattcag gacaaagaag ggattcctcc tgatcagcag 1560 cggctgattt ttgccggaaa acagctcgaa gatggacgga ccctgtccga ttacaatatt 1620 cagaaagaaa gcaccctcca tctggtcctg aggctgcggg gaggcgacat tcagatgaca 1680 cagtccccca gctccctgag cgccagcgtg ggagatcgcg tgaccattac atgccgggcc 1740 tcccagtgga ttggcatcct ggtggattgg tatcagcaga aacctgggga ggctcctaaa 1800 ctgctgatct attacgccag ctttctgcag tccggcgtgc cctctagatt cagcggctct 1860 ggcttcggca cagatttcac actgaccatc tctagcctgc accctgaaga ttttgccaca 1920 tattactgtc agcaggccaa ccctgccccc ctgacattcg gccagggaac aaaggtcgag 1980 atcaagcgcg agcccaagtc ctgtgataag acacatacct gccccccctg cccagctcca 2040 gaactgctcg gaggaccttc tgtgtttctg tttccaccca agcctaagga tacactcatg 2100 atctccagaa cacctgaagt gacatgtgtg gtcgtcgacg tgtcacatga ggatccagaa 2160 gtcaagttta actggtatgt ggatggggtc gaggtgcaca atgccaaaac aaaacctcgg 2220 gaagaacagt ataattccac ctatagagtc gtgtctgtgc tcaccgtgct ccatcaggat 2280 tggctcaatg ggaaagaata caaatgtaaa gtctctaaca aagccctgcc cgctcctatc 2340 gaaaagacaa tctccaaggc caaaggacag cctcgcgagc ctcaggtcta caccctgcca 2400 ccttcccgcg aggaaatgac aaaaaatcag gtgtcactca cctgtctcgt gaaggggttt 2460 tacccctccg acattgccgt cgagtgggag tccaatggac agcccgagaa caattataag 2520 acaacacctc ccgtcctgga ctccgatgga tcattttttc tgtactccaa gctcaccgtc 2580 gataagtcca gatggcagca gggaaatgtc ttttcctgct ccgtgatgca tgaagctctc 2640 cacaatcatt acacacagaa aagcctgtcc ctgtcccccg gcaagtgact cgag 2694 <210> 50 <211> 2709 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #6 <400> 50 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtag agccagccag tggatcggcc ctgagctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca ccagcatcct gcagagcggc 240 gtgcccagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagt acatgttcca gccccggacc 360 tttggccagg gcaccaaggt ggaaatcaga agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtggtggtt ctggtggcgg aggatctggc ggtggtggat ctgggggagg tggaagtggt 1380 ggcggtggta gtggtggtgg cggaagcgga ggcggtggat caggcggagg cggatcaggt 1440 ggcgggggtt caatgcagat ttttgtcaag acactgaccg ggaaaacaat cacactcgaa 1500 gtcgagccct ccgatacaat tgagaatgtg aaagccaaaa ttcaggacaa agaagggatt 1560 cctcctgatc agcagcggct gatttttgcc ggaaaacagc tcgaagatgg acggaccctg 1620 tccgattaca atattcagaa agaaagcacc ctccatctgg tcctgaggct gcggggaggc 1680 gacattcaga tgacacagtc ccccagctcc ctgagcgcca gcgtgggaga tcgcgtgacc 1740 attacatgcc gggcctccca gtggattggc atcctggtgg attggtatca gcagaaacct 1800 ggggaggctc ctaaactgct gatctattac gccagctttc tgcagtccgg cgtgccctct 1860 agattcagcg gctctggctt cggcacagat ttcacactga ccatctctag cctgcaccct 1920 gaagattttg ccacatatta ctgtcagcag gccaaccctg cccccctgac attcggccag 1980 ggaacaaagg tcgagatcaa gcgcgagccc aagtcctgtg ataagacaca tacctgcccc 2040 ccctgcccag ctccagaact gctcggagga ccttctgtgt ttctgtttcc acccaagcct 2100 aaggatacac tcatgatctc cagaacacct gaagtgacat gtgtggtcgt cgacgtgtca 2160 catgaggatc cagaagtcaa gtttaactgg tatgtggatg gggtcgaggt gcacaatgcc 2220 aaaacaaaac ctcgggaaga acagtataat tccacctata gagtcgtgtc tgtgctcacc 2280 gtgctccatc aggattggct caatgggaaa gaatacaaat gtaaagtctc taacaaagcc 2340 ctgcccgctc ctatcgaaaa gacaatctcc aaggccaaag gacagcctcg cgagcctcag 2400 gtctacaccc tgccaccttc ccgcgaggaa atgacaaaaa atcaggtgtc actcacctgt 2460 ctcgtgaagg ggttttaccc ctccgacatt gccgtcgagt gggagtccaa tggacagccc 2520 gagaacaatt ataagacaac acctcccgtc ctggactccg atggatcatt ttttctgtac 2580 tccaagctca ccgtcgataa gtccagatgg cagcagggaa atgtcttttc ctgctccgtg 2640 atgcatgaag ctctccacaa tcattacaca cagaaaagcc tgtccctgtc ccccggcaag 2700 tgactcgag 2709 <210> 51 <211> 2724 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #7 <400> 51 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtag agccagccag tggatcggcc ctgagctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca ccagcatcct gcagagcggc 240 gtgcccagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagt acatgttcca gccccggacc 360 tttggccagg gcaccaaggt ggaaatcaga agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtggtggtt ctggtggcgg aggatctggc ggtggtggat ctgggggagg tggaagtggt 1380 ggcggtggta gtggtggtgg cggaagcgga ggcggtggat caggcggagg cggatcaggt 1440 ggcgggggtt cagggggtgg cggaagtatg cagatttttg tcaagacact gaccgggaaa 1500 acaatcacac tcgaagtcga gccctccgat acaattgaga atgtgaaagc caaaattcag 1560 gacaaagaag ggattcctcc tgatcagcag cggctgattt ttgccggaaa acagctcgaa 1620 gatggacgga ccctgtccga ttacaatatt cagaaagaaa gcaccctcca tctggtcctg 1680 aggctgcggg gaggcgacat tcagatgaca cagtccccca gctccctgag cgccagcgtg 1740 ggagatcgcg tgaccattac atgccgggcc tcccagtgga ttggcatcct ggtggattgg 1800 tatcagcaga aacctgggga ggctcctaaa ctgctgatct attacgccag ctttctgcag 1860 tccggcgtgc cctctagatt cagcggctct ggcttcggca cagatttcac actgaccatc 1920 tctagcctgc accctgaaga ttttgccaca tattactgtc agcaggccaa ccctgccccc 1980 ctgacattcg gccagggaac aaaggtcgag atcaagcgcg agcccaagtc ctgtgataag 2040 acacatacct gccccccctg cccagctcca gaactgctcg gaggaccttc tgtgtttctg 2100 tttccaccca agcctaagga tacactcatg atctccagaa cacctgaagt gacatgtgtg 2160 gtcgtcgacg tgtcacatga ggatccagaa gtcaagttta actggtatgt ggatggggtc 2220 gaggtgcaca atgccaaaac aaaacctcgg gaagaacagt ataattccac ctatagagtc 2280 gtgtctgtgc tcaccgtgct ccatcaggat tggctcaatg ggaaagaata caaatgtaaa 2340 gtctctaaca aagccctgcc cgctcctatc gaaaagacaa tctccaaggc caaaggacag 2400 cctcgcgagc ctcaggtcta caccctgcca ccttcccgcg aggaaatgac aaaaaatcag 2460 gtgtcactca cctgtctcgt gaaggggttt tacccctccg acattgccgt cgagtgggag 2520 tccaatggac agcccgagaa caattataag acaacacctc ccgtcctgga ctccgatgga 2580 tcattttttc tgtactccaa gctcaccgtc gataagtcca gatggcagca gggaaatgtc 2640 ttttcctgct ccgtgatgca tgaagctctc cacaatcatt acacacagaa aagcctgtcc 2700 ctgtcccccg gcaagtgact cgag 2724 <210> 52 <211> 2634 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #8 <400> 52 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtag agccagccag tggatcggcc ctgagctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca ccagcatcct gcagagcggc 240 gtgcccagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagt acatgttcca gccccggacc 360 tttggccagg gcaccaaggt ggaaatcaga agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtggtggtt ctggtggcgg aggatctggc ggtggtggat ctgggggagg tggaagtatg 1380 cagatttttg tcaagacact gaccgggaaa acaatcacac tcgaagtcga gccctccgat 1440 acaattgaga atgtgaaagc caaaattcag gacaaagaag ggattcctcc tgatcagcag 1500 cggctgattt ttgccggaaa acagctcgaa gatggacgga ccctgtccga ttacaatatt 1560 cagaaagaaa gcaccctcca tctggtcctg aggctgcggg gaggcgacat tcagatgaca 1620 cagtccccca cctccctgtc tgccagcgtg ggagatcgcg tgaccattac atgccgggcc 1680 tcccagtgga ttggcaacct gctggattgg tatcagcaga aacctgggga ggctcctaaa 1740 ctgctgatct attacgccag ctttctgcag tccggcgtgc cctccagatt cagcggcgga 1800 ggcttcggca cagatttcac actgaccatc tcatccctgc agcctgaaga ttttgccaca 1860 tattattgcc agcaggccaa ccctgccccc ctgacattcg gccagggaac aaaggtcgag 1920 atcaagcgcg agcccaagtc ctgtgataag acacatacct gccccccctg cccagctcca 1980 gaactgctcg gaggaccttc tgtgtttctg tttccaccca agcctaagga tacactcatg 2040 atctccagaa cacctgaagt gacatgtgtg gtcgtcgacg tgtcacatga ggatccagaa 2100 gtcaagttta actggtatgt ggatggggtc gaggtgcaca atgccaaaac aaaacctcgg 2160 gaagaacagt ataattccac ctatagagtc gtgtctgtgc tcaccgtgct ccatcaggat 2220 tggctcaatg ggaaagaata caaatgtaaa gtctctaaca aagccctgcc cgctcctatc 2280 gaaaagacaa tctccaaggc caaaggacag cctcgcgagc ctcaggtcta caccctgcca 2340 cctagccgcg aggaaatgac aaaaaatcag gtgtcactca cctgtctcgt gaaggggttt 2400 tacccctccg acattgccgt cgagtgggag tccaatggac agcccgagaa caattataag 2460 acaacacctc ccgtcctgga ctccgatgga tcattttttc tgtactccaa gctcaccgtc 2520 gataagtcca gatggcagca gggaaatgtc ttttcctgct ccgtgatgca tgaagctctc 2580 cacaatcatt acacacagaa aagcctgtcc ctgtcccccg gcaagtgact cgag 2634 <210> 53 <211> 2649 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #9 <400> 53 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtag agccagccag tggatcggcc ctgagctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca ccagcatcct gcagagcggc 240 gtgcccagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagt acatgttcca gccccggacc 360 tttggccagg gcaccaaggt ggaaatcaga agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtggtggtt ctggtggcgg aggatctggc ggtggtggat ctgggggagg tggaagtggt 1380 ggcggtggta gtatgcagat ttttgtcaag acactgaccg ggaaaacaat cacactcgaa 1440 gtcgagccct ccgatacaat tgagaatgtg aaagccaaaa ttcaggacaa agaagggatt 1500 cctcctgatc agcagcggct gatttttgcc ggaaaacagc tcgaagatgg acggaccctg 1560 tccgattaca atattcagaa agaaagcacc ctccatctgg tcctgaggct gcggggaggc 1620 gacattcaga tgacacagtc ccccacctcc ctgtctgcca gcgtgggaga tcgcgtgacc 1680 attacatgcc gggcctccca gtggattggc aacctgctgg attggtatca gcagaaacct 1740 ggggaggctc ctaaactgct gatctattac gccagctttc tgcagtccgg cgtgccctcc 1800 agattcagcg gcggaggctt cggcacagat ttcacactga ccatctcatc cctgcagcct 1860 gaagattttg ccacatatta ttgccagcag gccaaccctg cccccctgac attcggccag 1920 ggaacaaagg tcgagatcaa gcgcgagccc aagtcctgtg ataagacaca tacctgcccc 1980 ccctgcccag ctccagaact gctcggagga ccttctgtgt ttctgtttcc acccaagcct 2040 aaggatacac tcatgatctc cagaacacct gaagtgacat gtgtggtcgt cgacgtgtca 2100 catgaggatc cagaagtcaa gtttaactgg tatgtggatg gggtcgaggt gcacaatgcc 2160 aaaacaaaac ctcgggaaga acagtataat tccacctata gagtcgtgtc tgtgctcacc 2220 gtgctccatc aggattggct caatgggaaa gaatacaaat gtaaagtctc taacaaagcc 2280 ctgcccgctc ctatcgaaaa gacaatctcc aaggccaaag gacagcctcg cgagcctcag 2340 gtctacaccc tgccacctag ccgcgaggaa atgacaaaaa atcaggtgtc actcacctgt 2400 ctcgtgaagg ggttttaccc ctccgacatt gccgtcgagt gggagtccaa tggacagccc 2460 gagaacaatt ataagacaac acctcccgtc ctggactccg atggatcatt ttttctgtac 2520 tccaagctca ccgtcgataa gtccagatgg cagcagggaa atgtcttttc ctgctccgtg 2580 atgcatgaag ctctccacaa tcattacaca cagaaaagcc tgtccctgtc ccccggcaag 2640 tgactcgag 2649 <210> 54 <211> 2664 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #10 <400> 54 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtag agccagccag tggatcggcc ctgagctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca ccagcatcct gcagagcggc 240 gtgcccagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagt acatgttcca gccccggacc 360 tttggccagg gcaccaaggt ggaaatcaga agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtggtggtt ctggtggcgg aggatctggc ggtggtggat ctgggggagg tggaagtggt 1380 ggcggtggta gtggtggtgg cggaagcatg cagatttttg tcaagacact gaccgggaaa 1440 acaatcacac tcgaagtcga gccctccgat acaattgaga atgtgaaagc caaaattcag 1500 gacaaagaag ggattcctcc tgatcagcag cggctgattt ttgccggaaa acagctcgaa 1560 gatggacgga ccctgtccga ttacaatatt cagaaagaaa gcaccctcca tctggtcctg 1620 aggctgcggg gaggcgacat tcagatgaca cagtccccca cctccctgtc tgccagcgtg 1680 ggagatcgcg tgaccattac atgccgggcc tcccagtgga ttggcaacct gctggattgg 1740 tatcagcaga aacctgggga ggctcctaaa ctgctgatct attacgccag ctttctgcag 1800 tccggcgtgc cctccagatt cagcggcgga ggcttcggca cagatttcac actgaccatc 1860 tcatccctgc agcctgaaga ttttgccaca tattattgcc agcaggccaa ccctgccccc 1920 ctgacattcg gccagggaac aaaggtcgag atcaagcgcg agcccaagtc ctgtgataag 1980 acacatacct gccccccctg cccagctcca gaactgctcg gaggaccttc tgtgtttctg 2040 tttccaccca agcctaagga tacactcatg atctccagaa cacctgaagt gacatgtgtg 2100 gtcgtcgacg tgtcacatga ggatccagaa gtcaagttta actggtatgt ggatggggtc 2160 gaggtgcaca atgccaaaac aaaacctcgg gaagaacagt ataattccac ctatagagtc 2220 gtgtctgtgc tcaccgtgct ccatcaggat tggctcaatg ggaaagaata caaatgtaaa 2280 gtctctaaca aagccctgcc cgctcctatc gaaaagacaa tctccaaggc caaaggacag 2340 cctcgcgagc ctcaggtcta caccctgcca cctagccgcg aggaaatgac aaaaaatcag 2400 gtgtcactca cctgtctcgt gaaggggttt tacccctccg acattgccgt cgagtgggag 2460 tccaatggac agcccgagaa caattataag acaacacctc ccgtcctgga ctccgatgga 2520 tcattttttc tgtactccaa gctcaccgtc gataagtcca gatggcagca gggaaatgtc 2580 ttttcctgct ccgtgatgca tgaagctctc cacaatcatt acacacagaa aagcctgtcc 2640 ctgtcccccg gcaagtgact cgag 2664 <210> 55 <211> 2679 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #11 <400> 55 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtag agccagccag tggatcggcc ctgagctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca ccagcatcct gcagagcggc 240 gtgcccagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagt acatgttcca gccccggacc 360 tttggccagg gcaccaaggt ggaaatcaga agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtggtggtt ctggtggcgg aggatctggc ggtggtggat ctgggggagg tggaagtggt 1380 ggcggtggta gtggtggtgg cggaagcgga ggcggtggat caatgcagat ttttgtcaag 1440 acactgaccg ggaaaacaat cacactcgaa gtcgagccct ccgatacaat tgagaatgtg 1500 aaagccaaaa ttcaggacaa agaagggatt cctcctgatc agcagcggct gatttttgcc 1560 ggaaaacagc tcgaagatgg acggaccctg tccgattaca atattcagaa agaaagcacc 1620 ctccatctgg tcctgaggct gcggggaggc gacattcaga tgacacagtc ccccacctcc 1680 ctgtctgcca gcgtgggaga tcgcgtgacc attacatgcc gggcctccca gtggattggc 1740 aacctgctgg attggtatca gcagaaacct ggggaggctc ctaaactgct gatctattac 1800 gccagctttc tgcagtccgg cgtgccctcc agattcagcg gcggaggctt cggcacagat 1860 ttcacactga ccatctcatc cctgcagcct gaagattttg ccacatatta ttgccagcag 1920 gccaaccctg cccccctgac attcggccag ggaacaaagg tcgagatcaa gcgcgagccc 1980 aagtcctgtg ataagacaca tacctgcccc ccctgcccag ctccagaact gctcggagga 2040 ccttctgtgt ttctgtttcc acccaagcct aaggatacac tcatgatctc cagaacacct 2100 gaagtgacat gtgtggtcgt cgacgtgtca catgaggatc cagaagtcaa gtttaactgg 2160 tatgtggatg gggtcgaggt gcacaatgcc aaaacaaaac ctcgggaaga acagtataat 2220 tccacctata gagtcgtgtc tgtgctcacc gtgctccatc aggattggct caatgggaaa 2280 gaatacaaat gtaaagtctc taacaaagcc ctgcccgctc ctatcgaaaa gacaatctcc 2340 aaggccaaag gacagcctcg cgagcctcag gtctacaccc tgccacctag ccgcgaggaa 2400 atgacaaaaa atcaggtgtc actcacctgt ctcgtgaagg ggttttaccc ctccgacatt 2460 gccgtcgagt gggagtccaa tggacagccc gagaacaatt ataagacaac acctcccgtc 2520 ctggactccg atggatcatt ttttctgtac tccaagctca ccgtcgataa gtccagatgg 2580 cagcagggaa atgtcttttc ctgctccgtg atgcatgaag ctctccacaa tcattacaca 2640 cagaaaagcc tgtccctgtc ccccggcaag tgactcgag 2679 <210> 56 <211> 2694 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #12 <400> 56 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtag agccagccag tggatcggcc ctgagctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca ccagcatcct gcagagcggc 240 gtgcccagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagt acatgttcca gccccggacc 360 tttggccagg gcaccaaggt ggaaatcaga agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtggtggtt ctggtggcgg aggatctggc ggtggtggat ctgggggagg tggaagtggt 1380 ggcggtggta gtggtggtgg cggaagcgga ggcggtggat caggcggagg cggatcaatg 1440 cagatttttg tcaagacact gaccgggaaa acaatcacac tcgaagtcga gccctccgat 1500 acaattgaga atgtgaaagc caaaattcag gacaaagaag ggattcctcc tgatcagcag 1560 cggctgattt ttgccggaaa acagctcgaa gatggacgga ccctgtccga ttacaatatt 1620 cagaaagaaa gcaccctcca tctggtcctg aggctgcggg gaggcgacat tcagatgaca 1680 cagtccccca cctccctgtc tgccagcgtg ggagatcgcg tgaccattac atgccgggcc 1740 tcccagtgga ttggcaacct gctggattgg tatcagcaga aacctgggga ggctcctaaa 1800 ctgctgatct attacgccag ctttctgcag tccggcgtgc cctccagatt cagcggcgga 1860 ggcttcggca cagatttcac actgaccatc tcatccctgc agcctgaaga ttttgccaca 1920 tattattgcc agcaggccaa ccctgccccc ctgacattcg gccagggaac aaaggtcgag 1980 atcaagcgcg agcccaagtc ctgtgataag acacatacct gccccccctg cccagctcca 2040 gaactgctcg gaggaccttc tgtgtttctg tttccaccca agcctaagga tacactcatg 2100 atctccagaa cacctgaagt gacatgtgtg gtcgtcgacg tgtcacatga ggatccagaa 2160 gtcaagttta actggtatgt ggatggggtc gaggtgcaca atgccaaaac aaaacctcgg 2220 gaagaacagt ataattccac ctatagagtc gtgtctgtgc tcaccgtgct ccatcaggat 2280 tggctcaatg ggaaagaata caaatgtaaa gtctctaaca aagccctgcc cgctcctatc 2340 gaaaagacaa tctccaaggc caaaggacag cctcgcgagc ctcaggtcta caccctgcca 2400 cctagccgcg aggaaatgac aaaaaatcag gtgtcactca cctgtctcgt gaaggggttt 2460 tacccctccg acattgccgt cgagtgggag tccaatggac agcccgagaa caattataag 2520 acaacacctc ccgtcctgga ctccgatgga tcattttttc tgtactccaa gctcaccgtc 2580 gataagtcca gatggcagca gggaaatgtc ttttcctgct ccgtgatgca tgaagctctc 2640 cacaatcatt acacacagaa aagcctgtcc ctgtcccccg gcaagtgact cgag 2694 <210> 57 <211> 2709 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #13 <400> 57 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtag agccagccag tggatcggcc ctgagctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca ccagcatcct gcagagcggc 240 gtgcccagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagt acatgttcca gccccggacc 360 tttggccagg gcaccaaggt ggaaatcaga agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtggtggtt ctggtggcgg aggatctggc ggtggtggat ctgggggagg tggaagtggt 1380 ggcggtggta gtggtggtgg cggaagcgga ggcggtggat caggcggagg cggatcaggt 1440 ggcggcggaa gtatgcagat ttttgtcaag acactgaccg ggaaaacaat cacactcgaa 1500 gtcgagccct ccgatacaat tgagaatgtg aaagccaaaa ttcaggacaa agaagggatt 1560 cctcctgatc agcagcggct gatttttgcc ggaaaacagc tcgaagatgg acggaccctg 1620 tccgattaca atattcagaa agaaagcacc ctccatctgg tcctgaggct gcggggaggc 1680 gacattcaga tgacacagtc ccccacctcc ctgtctgcca gcgtgggaga tcgcgtgacc 1740 attacatgcc gggcctccca gtggattggc aacctgctgg attggtatca gcagaaacct 1800 ggggaggctc ctaaactgct gatctattac gccagctttc tgcagtccgg cgtgccctcc 1860 agattcagcg gcggaggctt cggcacagat ttcacactga ccatctcatc cctgcagcct 1920 gaagattttg ccacatatta ttgccagcag gccaaccctg cccccctgac attcggccag 1980 ggaacaaagg tcgagatcaa gcgcgagccc aagtcctgtg ataagacaca tacctgcccc 2040 ccctgcccag ctccagaact gctcggagga ccttctgtgt ttctgtttcc acccaagcct 2100 aaggatacac tcatgatctc cagaacacct gaagtgacat gtgtggtcgt cgacgtgtca 2160 catgaggatc cagaagtcaa gtttaactgg tatgtggatg gggtcgaggt gcacaatgcc 2220 aaaacaaaac ctcgggaaga acagtataat tccacctata gagtcgtgtc tgtgctcacc 2280 gtgctccatc aggattggct caatgggaaa gaatacaaat gtaaagtctc taacaaagcc 2340 ctgcccgctc ctatcgaaaa gacaatctcc aaggccaaag gacagcctcg cgagcctcag 2400 gtctacaccc tgccacctag ccgcgaggaa atgacaaaaa atcaggtgtc actcacctgt 2460 ctcgtgaagg ggttttaccc ctccgacatt gccgtcgagt gggagtccaa tggacagccc 2520 gagaacaatt ataagacaac acctcccgtc ctggactccg atggatcatt ttttctgtac 2580 tccaagctca ccgtcgataa gtccagatgg cagcagggaa atgtcttttc ctgctccgtg 2640 atgcatgaag ctctccacaa tcattacaca cagaaaagcc tgtccctgtc ccccggcaag 2700 tgactcgag 2709 <210> 58 <211> 2724 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #14 <400> 58 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtag agccagccag tggatcggcc ctgagctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca ccagcatcct gcagagcggc 240 gtgcccagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagt acatgttcca gccccggacc 360 tttggccagg gcaccaaggt ggaaatcaga agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtggtggtt ctggtggcgg aggatctggc ggtggtggat ctgggggagg tggaagtggt 1380 ggcggtggta gtggtggtgg cggaagcgga ggcggtggat caggcggagg cggatcaggt 1440 ggcggcggaa gtggcggagg cggcagcatg cagatttttg tcaagacact gaccgggaaa 1500 acaatcacac tcgaagtcga gccctccgat acaattgaga atgtgaaagc caaaattcag 1560 gacaaagaag ggattcctcc tgatcagcag cggctgattt ttgccggaaa acagctcgaa 1620 gatggacgga ccctgtccga ttacaatatt cagaaagaaa gcaccctcca tctggtcctg 1680 aggctgcggg gaggcgacat tcagatgaca cagtccccca cctccctgtc tgccagcgtg 1740 ggagatcgcg tgaccattac atgccgggcc tcccagtgga ttggcaacct gctggattgg 1800 tatcagcaga aacctgggga ggctcctaaa ctgctgatct attacgccag ctttctgcag 1860 tccggcgtgc cctccagatt cagcggcgga ggcttcggca cagatttcac actgaccatc 1920 tcatccctgc agcctgaaga ttttgccaca tattattgcc agcaggccaa ccctgccccc 1980 ctgacattcg gccagggaac aaaggtcgag atcaagcgcg agcccaagtc ctgtgataag 2040 acacatacct gccccccctg cccagctcca gaactgctcg gaggaccttc tgtgtttctg 2100 tttccaccca agcctaagga tacactcatg atctccagaa cacctgaagt gacatgtgtg 2160 gtcgtcgacg tgtcacatga ggatccagaa gtcaagttta actggtatgt ggatggggtc 2220 gaggtgcaca atgccaaaac aaaacctcgg gaagaacagt ataattccac ctatagagtc 2280 gtgtctgtgc tcaccgtgct ccatcaggat tggctcaatg ggaaagaata caaatgtaaa 2340 gtctctaaca aagccctgcc cgctcctatc gaaaagacaa tctccaaggc caaaggacag 2400 cctcgcgagc ctcaggtcta caccctgcca cctagccgcg aggaaatgac aaaaaatcag 2460 gtgtcactca cctgtctcgt gaaggggttt tacccctccg acattgccgt cgagtgggag 2520 tccaatggac agcccgagaa caattataag acaacacctc ccgtcctgga ctccgatgga 2580 tcattttttc tgtactccaa gctcaccgtc gataagtcca gatggcagca gggaaatgtc 2640 ttttcctgct ccgtgatgca tgaagctctc cacaatcatt acacacagaa aagcctgtcc 2700 ctgtcccccg gcaagtgact cgag 2724 <210> 59 <211> 2634 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #15 <400> 59 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtcg ggccagccag aagatcttca acggcctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca gcagcaccct gcagagcggc 240 gtgccaagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagg tcctgctgta cccctacacc 360 tttggccagg gcaccaaggt ggaaatcaag agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtggtggtt ctggtggcgg aggatctggc ggtggtggat ctgggggagg tggaagtatg 1380 cagatttttg tcaagacact gaccgggaaa acaatcacac tcgaagtcga gccctccgat 1440 acaattgaga atgtgaaagc caaaattcag gacaaagaag ggattcctcc tgatcagcag 1500 cggctgattt ttgccggaaa acagctcgaa gatggacgga ccctgtccga ttacaatatt 1560 cagaaagaaa gcaccctcca tctggtcctg aggctgcggg gaggcgacat tcagatgaca 1620 cagtccccca gctccctgag cgccagcgtg ggagatcgcg tgaccattac ctgcagagcc 1680 tcccagtgga tcggcatcct ggtggattgg tatcagcaga aacctgggga ggctcctaaa 1740 ctgctgatct attacgccag cttcctgcag tccggcgtgc cctctagatt cagcggctct 1800 ggcttcggca cagatttcac actgaccatc tctagcctgc accctgaaga ttttgccaca 1860 tattactgtc agcaggccaa ccctgccccc ctgacatttg gacagggaac aaaggtcgag 1920 atcaagcgcg agcctaagtc ctgtgacaag acacacacat gccctccctg cccagcccca 1980 gaactgctcg gtggaccctc tgtgtttctg tttccaccca agcctaagga tacactcatg 2040 atctccagaa cacctgaagt gacatgtgtg gtcgtcgacg tgtcacatga ggatccagaa 2100 gtcaagttta actggtatgt ggatggggtc gaggtgcaca atgccaaaac aaaacctcgg 2160 gaagaacagt ataattccac ctatagagtc gtgtctgtgc tcaccgtgct ccatcaggat 2220 tggctcaatg ggaaagaata caaatgtaaa gtctctaaca aagccctgcc cgctcctatc 2280 gaaaagacaa tctccaaggc caaaggacag cctcgcgagc ctcaggtcta caccctgcca 2340 ccttcccgcg aggaaatgac aaaaaatcag gtgtcactca cctgtctcgt gaaggggttt 2400 tacccctccg acattgccgt cgagtgggag tccaatggac agcccgagaa caattataag 2460 acaacacctc ccgtcctgga ctccgatgga tcattttttc tgtactccaa gctcaccgtc 2520 gataagtcca gatggcagca gggaaatgtc ttttcctgct ccgtgatgca tgaagctctc 2580 cacaatcatt acacacagaa aagcctgtcc ctgtcccccg gcaagtgact cgag 2634 <210> 60 <211> 2649 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #16 <400> 60 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtcg ggccagccag aagatcttca acggcctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca gcagcaccct gcagagcggc 240 gtgccaagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagg tcctgctgta cccctacacc 360 tttggccagg gcaccaaggt ggaaatcaag agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtggtggtt ctggtggcgg aggatctggc ggtggtggat ctgggggagg tggaagtggt 1380 ggcggtggta gtatgcagat ttttgtcaag acactgaccg ggaaaacaat cacactcgaa 1440 gtcgagccct ccgatacaat tgagaatgtg aaagccaaaa ttcaggacaa agaagggatt 1500 cctcctgatc agcagcggct gatttttgcc ggaaaacagc tcgaagatgg acggaccctg 1560 tccgattaca atattcagaa agaaagcacc ctccatctgg tcctgaggct gcggggaggc 1620 gacattcaga tgacacagtc ccccagctcc ctgagcgcca gcgtgggaga tcgcgtgacc 1680 attacctgca gagcctccca gtggatcggc atcctggtgg attggtatca gcagaaacct 1740 ggggaggctc ctaaactgct gatctattac gccagcttcc tgcagtccgg cgtgccctct 1800 agattcagcg gctctggctt cggcacagat ttcacactga ccatctctag cctgcaccct 1860 gaagattttg ccacatatta ctgtcagcag gccaaccctg cccccctgac atttggacag 1920 ggaacaaagg tcgagatcaa gcgcgagcct aagtcctgtg acaagacaca cacatgccct 1980 ccctgcccag ccccagaact gctcggtgga ccctctgtgt ttctgtttcc acccaagcct 2040 aaggatacac tcatgatctc cagaacacct gaagtgacat gtgtggtcgt cgacgtgtca 2100 catgaggatc cagaagtcaa gtttaactgg tatgtggatg gggtcgaggt gcacaatgcc 2160 aaaacaaaac ctcgggaaga acagtataat tccacctata gagtcgtgtc tgtgctcacc 2220 gtgctccatc aggattggct caatgggaaa gaatacaaat gtaaagtctc taacaaagcc 2280 ctgcccgctc ctatcgaaaa gacaatctcc aaggccaaag gacagcctcg cgagcctcag 2340 gtctacaccc tgccaccttc ccgcgaggaa atgacaaaaa atcaggtgtc actcacctgt 2400 ctcgtgaagg ggttttaccc ctccgacatt gccgtcgagt gggagtccaa tggacagccc 2460 gagaacaatt ataagacaac acctcccgtc ctggactccg atggatcatt ttttctgtac 2520 tccaagctca ccgtcgataa gtccagatgg cagcagggaa atgtcttttc ctgctccgtg 2580 atgcatgaag ctctccacaa tcattacaca cagaaaagcc tgtccctgtc ccccggcaag 2640 tgactcgag 2649 <210> 61 <211> 2664 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #17 <400> 61 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtcg ggccagccag aagatcttca acggcctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca gcagcaccct gcagagcggc 240 gtgccaagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagg tcctgctgta cccctacacc 360 tttggccagg gcaccaaggt ggaaatcaag agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtggtggtt ctggtggcgg aggatctggc ggtggtggat ctgggggagg tggaagtggt 1380 ggcggtggta gtggtggtgg cggaagcatg cagatttttg tcaagacact gaccgggaaa 1440 acaatcacac tcgaagtcga gccctccgat acaattgaga atgtgaaagc caaaattcag 1500 gacaaagaag ggattcctcc tgatcagcag cggctgattt ttgccggaaa acagctcgaa 1560 gatggacgga ccctgtccga ttacaatatt cagaaagaaa gcaccctcca tctggtcctg 1620 aggctgcggg gaggcgacat tcagatgaca cagtccccca gctccctgag cgccagcgtg 1680 ggagatcgcg tgaccattac ctgcagagcc tcccagtgga tcggcatcct ggtggattgg 1740 tatcagcaga aacctgggga ggctcctaaa ctgctgatct attacgccag cttcctgcag 1800 tccggcgtgc cctctagatt cagcggctct ggcttcggca cagatttcac actgaccatc 1860 tctagcctgc accctgaaga ttttgccaca tattactgtc agcaggccaa ccctgccccc 1920 ctgacatttg gacagggaac aaaggtcgag atcaagcgcg agcctaagtc ctgtgacaag 1980 acacacacat gccctccctg cccagcccca gaactgctcg gtggaccctc tgtgtttctg 2040 tttccaccca agcctaagga tacactcatg atctccagaa cacctgaagt gacatgtgtg 2100 gtcgtcgacg tgtcacatga ggatccagaa gtcaagttta actggtatgt ggatggggtc 2160 gaggtgcaca atgccaaaac aaaacctcgg gaagaacagt ataattccac ctatagagtc 2220 gtgtctgtgc tcaccgtgct ccatcaggat tggctcaatg ggaaagaata caaatgtaaa 2280 gtctctaaca aagccctgcc cgctcctatc gaaaagacaa tctccaaggc caaaggacag 2340 cctcgcgagc ctcaggtcta caccctgcca ccttcccgcg aggaaatgac aaaaaatcag 2400 gtgtcactca cctgtctcgt gaaggggttt tacccctccg acattgccgt cgagtgggag 2460 tccaatggac agcccgagaa caattataag acaacacctc ccgtcctgga ctccgatgga 2520 tcattttttc tgtactccaa gctcaccgtc gataagtcca gatggcagca gggaaatgtc 2580 ttttcctgct ccgtgatgca tgaagctctc cacaatcatt acacacagaa aagcctgtcc 2640 ctgtcccccg gcaagtgact cgag 2664 <210> 62 <211> 2679 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #18 <400> 62 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtcg ggccagccag aagatcttca acggcctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca gcagcaccct gcagagcggc 240 gtgccaagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagg tcctgctgta cccctacacc 360 tttggccagg gcaccaaggt ggaaatcaag agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtggtggtt ctggtggcgg aggatctggc ggtggtggat ctgggggagg tggaagtggt 1380 ggcggtggta gtggtggtgg cggaagcgga ggcggtggat caatgcagat ttttgtcaag 1440 acactgaccg ggaaaacaat cacactcgaa gtcgagccct ccgatacaat tgagaatgtg 1500 aaagccaaaa ttcaggacaa agaagggatt cctcctgatc agcagcggct gatttttgcc 1560 ggaaaacagc tcgaagatgg acggaccctg tccgattaca atattcagaa agaaagcacc 1620 ctccatctgg tcctgaggct gcggggaggc gacattcaga tgacacagtc ccccagctcc 1680 ctgagcgcca gcgtgggaga tcgcgtgacc attacctgca gagcctccca gtggatcggc 1740 atcctggtgg attggtatca gcagaaacct ggggaggctc ctaaactgct gatctattac 1800 gccagcttcc tgcagtccgg cgtgccctct agattcagcg gctctggctt cggcacagat 1860 ttcacactga ccatctctag cctgcaccct gaagattttg ccacatatta ctgtcagcag 1920 gccaaccctg cccccctgac atttggacag ggaacaaagg tcgagatcaa gcgcgagcct 1980 aagtcctgtg acaagacaca cacatgccct ccctgcccag ccccagaact gctcggtgga 2040 ccctctgtgt ttctgtttcc acccaagcct aaggatacac tcatgatctc cagaacacct 2100 gaagtgacat gtgtggtcgt cgacgtgtca catgaggatc cagaagtcaa gtttaactgg 2160 tatgtggatg gggtcgaggt gcacaatgcc aaaacaaaac ctcgggaaga acagtataat 2220 tccacctata gagtcgtgtc tgtgctcacc gtgctccatc aggattggct caatgggaaa 2280 gaatacaaat gtaaagtctc taacaaagcc ctgcccgctc ctatcgaaaa gacaatctcc 2340 aaggccaaag gacagcctcg cgagcctcag gtctacaccc tgccaccttc ccgcgaggaa 2400 atgacaaaaa atcaggtgtc actcacctgt ctcgtgaagg ggttttaccc ctccgacatt 2460 gccgtcgagt gggagtccaa tggacagccc gagaacaatt ataagacaac acctcccgtc 2520 ctggactccg atggatcatt ttttctgtac tccaagctca ccgtcgataa gtccagatgg 2580 cagcagggaa atgtcttttc ctgctccgtg atgcatgaag ctctccacaa tcattacaca 2640 cagaaaagcc tgtccctgtc ccccggcaag tgactcgag 2679 <210> 63 <211> 2694 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #19 <400> 63 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtcg ggccagccag aagatcttca acggcctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca gcagcaccct gcagagcggc 240 gtgccaagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagg tcctgctgta cccctacacc 360 tttggccagg gcaccaaggt ggaaatcaag agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtggtggtt ctggtggcgg aggatctggc ggtggtggat ctgggggagg tggaagtggt 1380 ggcggtggta gtggtggtgg cggaagcgga ggcggtggat caggcggagg cggatcaatg 1440 cagatttttg tcaagacact gaccgggaaa acaatcacac tcgaagtcga gccctccgat 1500 acaattgaga atgtgaaagc caaaattcag gacaaagaag ggattcctcc tgatcagcag 1560 cggctgattt ttgccggaaa acagctcgaa gatggacgga ccctgtccga ttacaatatt 1620 cagaaagaaa gcaccctcca tctggtcctg aggctgcggg gaggcgacat tcagatgaca 1680 cagtccccca gctccctgag cgccagcgtg ggagatcgcg tgaccattac ctgcagagcc 1740 tcccagtgga tcggcatcct ggtggattgg tatcagcaga aacctgggga ggctcctaaa 1800 ctgctgatct attacgccag cttcctgcag tccggcgtgc cctctagatt cagcggctct 1860 ggcttcggca cagatttcac actgaccatc tctagcctgc accctgaaga ttttgccaca 1920 tattactgtc agcaggccaa ccctgccccc ctgacatttg gacagggaac aaaggtcgag 1980 atcaagcgcg agcctaagtc ctgtgacaag acacacacat gccctccctg cccagcccca 2040 gaactgctcg gtggaccctc tgtgtttctg tttccaccca agcctaagga tacactcatg 2100 atctccagaa cacctgaagt gacatgtgtg gtcgtcgacg tgtcacatga ggatccagaa 2160 gtcaagttta actggtatgt ggatggggtc gaggtgcaca atgccaaaac aaaacctcgg 2220 gaagaacagt ataattccac ctatagagtc gtgtctgtgc tcaccgtgct ccatcaggat 2280 tggctcaatg ggaaagaata caaatgtaaa gtctctaaca aagccctgcc cgctcctatc 2340 gaaaagacaa tctccaaggc caaaggacag cctcgcgagc ctcaggtcta caccctgcca 2400 ccttcccgcg aggaaatgac aaaaaatcag gtgtcactca cctgtctcgt gaaggggttt 2460 tacccctccg acattgccgt cgagtgggag tccaatggac agcccgagaa caattataag 2520 acaacacctc ccgtcctgga ctccgatgga tcattttttc tgtactccaa gctcaccgtc 2580 gataagtcca gatggcagca gggaaatgtc ttttcctgct ccgtgatgca tgaagctctc 2640 cacaatcatt acacacagaa aagcctgtcc ctgtcccccg gcaagtgact cgag 2694 <210> 64 <211> 2709 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #20 <400> 64 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtcg ggccagccag aagatcttca acggcctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca gcagcaccct gcagagcggc 240 gtgccaagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagg tcctgctgta cccctacacc 360 tttggccagg gcaccaaggt ggaaatcaag agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtggtggtt ctggtggcgg aggatctggc ggtggtggat ctgggggagg tggaagtggt 1380 ggcggtggta gtggtggtgg cggaagcgga ggcggtggat caggcggagg cggatcaggt 1440 ggcgggggtt caatgcagat ttttgtcaag acactgaccg ggaaaacaat cacactcgaa 1500 gtcgagccct ccgatacaat tgagaatgtg aaagccaaaa ttcaggacaa agaagggatt 1560 cctcctgatc agcagcggct gatttttgcc ggaaaacagc tcgaagatgg acggaccctg 1620 tccgattaca atattcagaa agaaagcacc ctccatctgg tcctgaggct gcggggaggc 1680 gacattcaga tgacacagtc ccccagctcc ctgagcgcca gcgtgggaga tcgcgtgacc 1740 attacctgca gagcctccca gtggatcggc atcctggtgg attggtatca gcagaaacct 1800 ggggaggctc ctaaactgct gatctattac gccagcttcc tgcagtccgg cgtgccctct 1860 agattcagcg gctctggctt cggcacagat ttcacactga ccatctctag cctgcaccct 1920 gaagattttg ccacatatta ctgtcagcag gccaaccctg cccccctgac atttggacag 1980 ggaacaaagg tcgagatcaa gcgcgagcct aagtcctgtg acaagacaca cacatgccct 2040 ccctgcccag ccccagaact gctcggtgga ccctctgtgt ttctgtttcc acccaagcct 2100 aaggatacac tcatgatctc cagaacacct gaagtgacat gtgtggtcgt cgacgtgtca 2160 catgaggatc cagaagtcaa gtttaactgg tatgtggatg gggtcgaggt gcacaatgcc 2220 aaaacaaaac ctcgggaaga acagtataat tccacctata gagtcgtgtc tgtgctcacc 2280 gtgctccatc aggattggct caatgggaaa gaatacaaat gtaaagtctc taacaaagcc 2340 ctgcccgctc ctatcgaaaa gacaatctcc aaggccaaag gacagcctcg cgagcctcag 2400 gtctacaccc tgccaccttc ccgcgaggaa atgacaaaaa atcaggtgtc actcacctgt 2460 ctcgtgaagg ggttttaccc ctccgacatt gccgtcgagt gggagtccaa tggacagccc 2520 gagaacaatt ataagacaac acctcccgtc ctggactccg atggatcatt ttttctgtac 2580 tccaagctca ccgtcgataa gtccagatgg cagcagggaa atgtcttttc ctgctccgtg 2640 atgcatgaag ctctccacaa tcattacaca cagaaaagcc tgtccctgtc ccccggcaag 2700 tgactcgag 2709 <210> 65 <211> 2724 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #21 <400> 65 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtcg ggccagccag aagatcttca acggcctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca gcagcaccct gcagagcggc 240 gtgccaagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagg tcctgctgta cccctacacc 360 tttggccagg gcaccaaggt ggaaatcaag agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtggtggtt ctggtggcgg aggatctggc ggtggtggat ctgggggagg tggaagtggt 1380 ggcggtggta gtggtggtgg cggaagcgga ggcggtggat caggcggagg cggatcaggt 1440 ggcgggggtt cagggggtgg cggaagtatg cagatttttg tcaagacact gaccgggaaa 1500 acaatcacac tcgaagtcga gccctccgat acaattgaga atgtgaaagc caaaattcag 1560 gacaaagaag ggattcctcc tgatcagcag cggctgattt ttgccggaaa acagctcgaa 1620 gatggacgga ccctgtccga ttacaatatt cagaaagaaa gcaccctcca tctggtcctg 1680 aggctgcggg gaggcgacat tcagatgaca cagtccccca gctccctgag cgccagcgtg 1740 ggagatcgcg tgaccattac ctgcagagcc tcccagtgga tcggcatcct ggtggattgg 1800 tatcagcaga aacctgggga ggctcctaaa ctgctgatct attacgccag cttcctgcag 1860 tccggcgtgc cctctagatt cagcggctct ggcttcggca cagatttcac actgaccatc 1920 tctagcctgc accctgaaga ttttgccaca tattactgtc agcaggccaa ccctgccccc 1980 ctgacatttg gacagggaac aaaggtcgag atcaagcgcg agcctaagtc ctgtgacaag 2040 acacacacat gccctccctg cccagcccca gaactgctcg gtggaccctc tgtgtttctg 2100 tttccaccca agcctaagga tacactcatg atctccagaa cacctgaagt gacatgtgtg 2160 gtcgtcgacg tgtcacatga ggatccagaa gtcaagttta actggtatgt ggatggggtc 2220 gaggtgcaca atgccaaaac aaaacctcgg gaagaacagt ataattccac ctatagagtc 2280 gtgtctgtgc tcaccgtgct ccatcaggat tggctcaatg ggaaagaata caaatgtaaa 2340 gtctctaaca aagccctgcc cgctcctatc gaaaagacaa tctccaaggc caaaggacag 2400 cctcgcgagc ctcaggtcta caccctgcca ccttcccgcg aggaaatgac aaaaaatcag 2460 gtgtcactca cctgtctcgt gaaggggttt tacccctccg acattgccgt cgagtgggag 2520 tccaatggac agcccgagaa caattataag acaacacctc ccgtcctgga ctccgatgga 2580 tcattttttc tgtactccaa gctcaccgtc gataagtcca gatggcagca gggaaatgtc 2640 ttttcctgct ccgtgatgca tgaagctctc cacaatcatt acacacagaa aagcctgtcc 2700 ctgtcccccg gcaagtgact cgag 2724 <210> 66 <211> 2634 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #22 <400> 66 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtcg ggccagccag aagatcttca acggcctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca gcagcaccct gcagagcggc 240 gtgccaagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagg tcctgctgta cccctacacc 360 tttggccagg gcaccaaggt ggaaatcaag agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtggtggtt ctggtggcgg aggatctggc ggtggtggat ctgggggagg tggaagtatg 1380 cagatttttg tcaagacact gaccgggaaa acaatcacac tcgaagtcga gccctccgat 1440 acaattgaga atgtgaaagc caaaattcag gacaaagaag ggattcctcc tgatcagcag 1500 cggctgattt ttgccggaaa acagctcgaa gatggacgga ccctgtccga ttacaatatt 1560 cagaaagaaa gcaccctcca tctggtcctg aggctgcggg gaggcgacat tcagatgaca 1620 cagtccccca cctccctgtc tgccagcgtg ggagatcgcg tgaccattac ctgcagagcc 1680 tcccagtgga tcggcaacct gctggattgg tatcagcaga aacctgggga ggctcctaaa 1740 ctgctgatct attacgccag cttcctgcag tccggcgtgc cctctagatt ttccggcgga 1800 ggcttcggca cagatttcac actgaccatc tcatccctgc agcctgaaga ttttgccaca 1860 tattattgcc agcaggccaa ccctgccccc ctgacatttg gacagggaac aaaggtcgag 1920 atcaagcgcg agcctaagtc ctgtgacaag acacacacat gccctccctg cccagcccca 1980 gaactgctcg gtggaccctc tgtgtttctg tttccaccca agcctaagga tacactcatg 2040 atctccagaa cacctgaagt gacatgtgtg gtcgtcgacg tgtcacatga ggatccagaa 2100 gtcaagttta actggtatgt ggatggggtc gaggtgcaca atgccaaaac aaaacctcgg 2160 gaagaacagt ataattccac ctatagagtc gtgtctgtgc tcaccgtgct ccatcaggat 2220 tggctcaatg ggaaagaata caaatgtaaa gtctctaaca aagccctgcc cgctcctatc 2280 gaaaagacaa tctccaaggc caaaggacag cctcgcgagc ctcaggtcta caccctgcca 2340 ccttcccgcg aggaaatgac aaaaaatcag gtgtcactca cctgtctcgt gaaggggttt 2400 tacccctccg acattgccgt cgagtgggag tccaatggac agcccgagaa caattataag 2460 acaacacctc ccgtcctgga ctccgatgga tcattttttc tgtactccaa gctcaccgtc 2520 gataagtcca gatggcagca gggaaatgtc ttttcctgct ccgtgatgca tgaagctctc 2580 cacaatcatt acacacagaa aagcctgtcc ctgtcccccg gcaagtgact cgag 2634 <210> 67 <211> 2649 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #23 <400> 67 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtcg ggccagccag aagatcttca acggcctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca gcagcaccct gcagagcggc 240 gtgccaagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagg tcctgctgta cccctacacc 360 tttggccagg gcaccaaggt ggaaatcaag agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtggtggtt ctggtggcgg aggatctggc ggtggtggat ctgggggagg tggaagtggt 1380 ggcggtggta gtatgcagat ttttgtcaag acactgaccg ggaaaacaat cacactcgaa 1440 gtcgagccct ccgatacaat tgagaatgtg aaagccaaaa ttcaggacaa agaagggatt 1500 cctcctgatc agcagcggct gatttttgcc ggaaaacagc tcgaagatgg acggaccctg 1560 tccgattaca atattcagaa agaaagcacc ctccatctgg tcctgaggct gcggggaggc 1620 gacattcaga tgacacagtc ccccacctcc ctgtctgcca gcgtgggaga tcgcgtgacc 1680 attacctgca gagcctccca gtggatcggc aacctgctgg attggtatca gcagaaacct 1740 ggggaggctc ctaaactgct gatctattac gccagcttcc tgcagtccgg cgtgccctct 1800 agattttccg gcggaggctt cggcacagat ttcacactga ccatctcatc cctgcagcct 1860 gaagattttg ccacatatta ttgccagcag gccaaccctg cccccctgac atttggacag 1920 ggaacaaagg tcgagatcaa gcgcgagcct aagtcctgtg acaagacaca cacatgccct 1980 ccctgcccag ccccagaact gctcggtgga ccctctgtgt ttctgtttcc acccaagcct 2040 aaggatacac tcatgatctc cagaacacct gaagtgacat gtgtggtcgt cgacgtgtca 2100 catgaggatc cagaagtcaa gtttaactgg tatgtggatg gggtcgaggt gcacaatgcc 2160 aaaacaaaac ctcgggaaga acagtataat tccacctata gagtcgtgtc tgtgctcacc 2220 gtgctccatc aggattggct caatgggaaa gaatacaaat gtaaagtctc taacaaagcc 2280 ctgcccgctc ctatcgaaaa gacaatctcc aaggccaaag gacagcctcg cgagcctcag 2340 gtctacaccc tgccaccttc ccgcgaggaa atgacaaaaa atcaggtgtc actcacctgt 2400 ctcgtgaagg ggttttaccc ctccgacatt gccgtcgagt gggagtccaa tggacagccc 2460 gagaacaatt ataagacaac acctcccgtc ctggactccg atggatcatt ttttctgtac 2520 tccaagctca ccgtcgataa gtccagatgg cagcagggaa atgtcttttc ctgctccgtg 2580 atgcatgaag ctctccacaa tcattacaca cagaaaagcc tgtccctgtc ccccggcaag 2640 tgactcgag 2649 <210> 68 <211> 2664 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #24 <400> 68 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtcg ggccagccag aagatcttca acggcctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca gcagcaccct gcagagcggc 240 gtgccaagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagg tcctgctgta cccctacacc 360 tttggccagg gcaccaaggt ggaaatcaag agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtggtggtt ctggtggcgg aggatctggc ggtggtggat ctgggggagg tggaagtggt 1380 ggcggtggta gtggtggtgg cggaagcatg cagatttttg tcaagacact gaccgggaaa 1440 acaatcacac tcgaagtcga gccctccgat acaattgaga atgtgaaagc caaaattcag 1500 gacaaagaag ggattcctcc tgatcagcag cggctgattt ttgccggaaa acagctcgaa 1560 gatggacgga ccctgtccga ttacaatatt cagaaagaaa gcaccctcca tctggtcctg 1620 aggctgcggg gaggcgacat tcagatgaca cagtccccca cctccctgtc tgccagcgtg 1680 ggagatcgcg tgaccattac ctgcagagcc tcccagtgga tcggcaacct gctggattgg 1740 tatcagcaga aacctgggga ggctcctaaa ctgctgatct attacgccag cttcctgcag 1800 tccggcgtgc cctctagatt ttccggcgga ggcttcggca cagatttcac actgaccatc 1860 tcatccctgc agcctgaaga ttttgccaca tattattgcc agcaggccaa ccctgccccc 1920 ctgacatttg gacagggaac aaaggtcgag atcaagcgcg agcctaagtc ctgtgacaag 1980 acacacacat gccctccctg cccagcccca gaactgctcg gtggaccctc tgtgtttctg 2040 tttccaccca agcctaagga tacactcatg atctccagaa cacctgaagt gacatgtgtg 2100 gtcgtcgacg tgtcacatga ggatccagaa gtcaagttta actggtatgt ggatggggtc 2160 gaggtgcaca atgccaaaac aaaacctcgg gaagaacagt ataattccac ctatagagtc 2220 gtgtctgtgc tcaccgtgct ccatcaggat tggctcaatg ggaaagaata caaatgtaaa 2280 gtctctaaca aagccctgcc cgctcctatc gaaaagacaa tctccaaggc caaaggacag 2340 cctcgcgagc ctcaggtcta caccctgcca ccttcccgcg aggaaatgac aaaaaatcag 2400 gtgtcactca cctgtctcgt gaaggggttt tacccctccg acattgccgt cgagtgggag 2460 tccaatggac agcccgagaa caattataag acaacacctc ccgtcctgga ctccgatgga 2520 tcattttttc tgtactccaa gctcaccgtc gataagtcca gatggcagca gggaaatgtc 2580 ttttcctgct ccgtgatgca tgaagctctc cacaatcatt acacacagaa aagcctgtcc 2640 ctgtcccccg gcaagtgact cgag 2664 <210> 69 <211> 2679 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #25 <400> 69 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtcg ggccagccag aagatcttca acggcctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca gcagcaccct gcagagcggc 240 gtgccaagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagg tcctgctgta cccctacacc 360 tttggccagg gcaccaaggt ggaaatcaag agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtggtggtt ctggtggcgg aggatctggc ggtggtggat ctgggggagg tggaagtggt 1380 ggcggtggta gtggtggtgg cggaagcgga ggcggtggat caatgcagat ttttgtcaag 1440 acactgaccg ggaaaacaat cacactcgaa gtcgagccct ccgatacaat tgagaatgtg 1500 aaagccaaaa ttcaggacaa agaagggatt cctcctgatc agcagcggct gatttttgcc 1560 ggaaaacagc tcgaagatgg acggaccctg tccgattaca atattcagaa agaaagcacc 1620 ctccatctgg tcctgaggct gcggggaggc gacattcaga tgacacagtc ccccacctcc 1680 ctgtctgcca gcgtgggaga tcgcgtgacc attacctgca gagcctccca gtggatcggc 1740 aacctgctgg attggtatca gcagaaacct ggggaggctc ctaaactgct gatctattac 1800 gccagcttcc tgcagtccgg cgtgccctct agattttccg gcggaggctt cggcacagat 1860 ttcacactga ccatctcatc cctgcagcct gaagattttg ccacatatta ttgccagcag 1920 gccaaccctg cccccctgac atttggacag ggaacaaagg tcgagatcaa gcgcgagcct 1980 aagtcctgtg acaagacaca cacatgccct ccctgcccag ccccagaact gctcggtgga 2040 ccctctgtgt ttctgtttcc acccaagcct aaggatacac tcatgatctc cagaacacct 2100 gaagtgacat gtgtggtcgt cgacgtgtca catgaggatc cagaagtcaa gtttaactgg 2160 tatgtggatg gggtcgaggt gcacaatgcc aaaacaaaac ctcgggaaga acagtataat 2220 tccacctata gagtcgtgtc tgtgctcacc gtgctccatc aggattggct caatgggaaa 2280 gaatacaaat gtaaagtctc taacaaagcc ctgcccgctc ctatcgaaaa gacaatctcc 2340 aaggccaaag gacagcctcg cgagcctcag gtctacaccc tgccaccttc ccgcgaggaa 2400 atgacaaaaa atcaggtgtc actcacctgt ctcgtgaagg ggttttaccc ctccgacatt 2460 gccgtcgagt gggagtccaa tggacagccc gagaacaatt ataagacaac acctcccgtc 2520 ctggactccg atggatcatt ttttctgtac tccaagctca ccgtcgataa gtccagatgg 2580 cagcagggaa atgtcttttc ctgctccgtg atgcatgaag ctctccacaa tcattacaca 2640 cagaaaagcc tgtccctgtc ccccggcaag tgactcgag 2679 <210> 70 <211> 2694 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #26 <400> 70 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtcg ggccagccag aagatcttca acggcctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca gcagcaccct gcagagcggc 240 gtgccaagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagg tcctgctgta cccctacacc 360 tttggccagg gcaccaaggt ggaaatcaag agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtggtggtt ctggtggcgg aggatctggc ggtggtggat ctgggggagg tggaagtggt 1380 ggcggtggta gtggtggtgg cggaagcgga ggcggtggat caggcggagg cggatcaatg 1440 cagatttttg tcaagacact gaccgggaaa acaatcacac tcgaagtcga gccctccgat 1500 acaattgaga atgtgaaagc caaaattcag gacaaagaag ggattcctcc tgatcagcag 1560 cggctgattt ttgccggaaa acagctcgaa gatggacgga ccctgtccga ttacaatatt 1620 cagaaagaaa gcaccctcca tctggtcctg aggctgcggg gaggcgacat tcagatgaca 1680 cagtccccca cctccctgtc tgccagcgtg ggagatcgcg tgaccattac ctgcagagcc 1740 tcccagtgga tcggcaacct gctggattgg tatcagcaga aacctgggga ggctcctaaa 1800 ctgctgatct attacgccag cttcctgcag tccggcgtgc cctctagatt ttccggcgga 1860 ggcttcggca cagatttcac actgaccatc tcatccctgc agcctgaaga ttttgccaca 1920 tattattgcc agcaggccaa ccctgccccc ctgacatttg gacagggaac aaaggtcgag 1980 atcaagcgcg agcctaagtc ctgtgacaag acacacacat gccctccctg cccagcccca 2040 gaactgctcg gtggaccctc tgtgtttctg tttccaccca agcctaagga tacactcatg 2100 atctccagaa cacctgaagt gacatgtgtg gtcgtcgacg tgtcacatga ggatccagaa 2160 gtcaagttta actggtatgt ggatggggtc gaggtgcaca atgccaaaac aaaacctcgg 2220 gaagaacagt ataattccac ctatagagtc gtgtctgtgc tcaccgtgct ccatcaggat 2280 tggctcaatg ggaaagaata caaatgtaaa gtctctaaca aagccctgcc cgctcctatc 2340 gaaaagacaa tctccaaggc caaaggacag cctcgcgagc ctcaggtcta caccctgcca 2400 ccttcccgcg aggaaatgac aaaaaatcag gtgtcactca cctgtctcgt gaaggggttt 2460 tacccctccg acattgccgt cgagtgggag tccaatggac agcccgagaa caattataag 2520 acaacacctc ccgtcctgga ctccgatgga tcattttttc tgtactccaa gctcaccgtc 2580 gataagtcca gatggcagca gggaaatgtc ttttcctgct ccgtgatgca tgaagctctc 2640 cacaatcatt acacacagaa aagcctgtcc ctgtcccccg gcaagtgact cgag 2694 <210> 71 <211> 2709 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #27 <400> 71 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtcg ggccagccag aagatcttca acggcctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca gcagcaccct gcagagcggc 240 gtgccaagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagg tcctgctgta cccctacacc 360 tttggccagg gcaccaaggt ggaaatcaag agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtggtggtt ctggtggcgg aggatctggc ggtggtggat ctgggggagg tggaagtggt 1380 ggcggtggta gtggtggtgg cggaagcgga ggcggtggat caggcggagg cggatcaggt 1440 ggcgggggtt caatgcagat ttttgtcaag acactgaccg ggaaaacaat cacactcgaa 1500 gtcgagccct ccgatacaat tgagaatgtg aaagccaaaa ttcaggacaa agaagggatt 1560 cctcctgatc agcagcggct gatttttgcc ggaaaacagc tcgaagatgg acggaccctg 1620 tccgattaca atattcagaa agaaagcacc ctccatctgg tcctgaggct gcggggaggc 1680 gacattcaga tgacacagtc ccccacctcc ctgtctgcca gcgtgggaga tcgcgtgacc 1740 attacctgca gagcctccca gtggatcggc aacctgctgg attggtatca gcagaaacct 1800 ggggaggctc ctaaactgct gatctattac gccagcttcc tgcagtccgg cgtgccctct 1860 agattttccg gcggaggctt cggcacagat ttcacactga ccatctcatc cctgcagcct 1920 gaagattttg ccacatatta ttgccagcag gccaaccctg cccccctgac atttggacag 1980 ggaacaaagg tcgagatcaa gcgcgagcct aagtcctgtg acaagacaca cacatgccct 2040 ccctgcccag ccccagaact gctcggtgga ccctctgtgt ttctgtttcc acccaagcct 2100 aaggatacac tcatgatctc cagaacacct gaagtgacat gtgtggtcgt cgacgtgtca 2160 catgaggatc cagaagtcaa gtttaactgg tatgtggatg gggtcgaggt gcacaatgcc 2220 aaaacaaaac ctcgggaaga acagtataat tccacctata gagtcgtgtc tgtgctcacc 2280 gtgctccatc aggattggct caatgggaaa gaatacaaat gtaaagtctc taacaaagcc 2340 ctgcccgctc ctatcgaaaa gacaatctcc aaggccaaag gacagcctcg cgagcctcag 2400 gtctacaccc tgccaccttc ccgcgaggaa atgacaaaaa atcaggtgtc actcacctgt 2460 ctcgtgaagg ggttttaccc ctccgacatt gccgtcgagt gggagtccaa tggacagccc 2520 gagaacaatt ataagacaac acctcccgtc ctggactccg atggatcatt ttttctgtac 2580 tccaagctca ccgtcgataa gtccagatgg cagcagggaa atgtcttttc ctgctccgtg 2640 atgcatgaag ctctccacaa tcattacaca cagaaaagcc tgtccctgtc ccccggcaag 2700 tgactcgag 2709 <210> 72 <211> 2724 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #28 <400> 72 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtcg ggccagccag aagatcttca acggcctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca gcagcaccct gcagagcggc 240 gtgccaagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagg tcctgctgta cccctacacc 360 tttggccagg gcaccaaggt ggaaatcaag agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtggtggtt ctggtggcgg aggatctggc ggtggtggat ctgggggagg tggaagtggt 1380 ggcggtggta gtggtggtgg cggaagcgga ggcggtggat caggcggagg cggatcaggt 1440 ggcgggggtt cagggggtgg cggaagtatg cagatttttg tcaagacact gaccgggaaa 1500 acaatcacac tcgaagtcga gccctccgat acaattgaga atgtgaaagc caaaattcag 1560 gacaaagaag ggattcctcc tgatcagcag cggctgattt ttgccggaaa acagctcgaa 1620 gatggacgga ccctgtccga ttacaatatt cagaaagaaa gcaccctcca tctggtcctg 1680 aggctgcggg gaggcgacat tcagatgaca cagtccccca cctccctgtc tgccagcgtg 1740 ggagatcgcg tgaccattac ctgcagagcc tcccagtgga tcggcaacct gctggattgg 1800 tatcagcaga aacctgggga ggctcctaaa ctgctgatct attacgccag cttcctgcag 1860 tccggcgtgc cctctagatt ttccggcgga ggcttcggca cagatttcac actgaccatc 1920 tcatccctgc agcctgaaga ttttgccaca tattattgcc agcaggccaa ccctgccccc 1980 ctgacatttg gacagggaac aaaggtcgag atcaagcgcg agcctaagtc ctgtgacaag 2040 acacacacat gccctccctg cccagcccca gaactgctcg gtggaccctc tgtgtttctg 2100 tttccaccca agcctaagga tacactcatg atctccagaa cacctgaagt gacatgtgtg 2160 gtcgtcgacg tgtcacatga ggatccagaa gtcaagttta actggtatgt ggatggggtc 2220 gaggtgcaca atgccaaaac aaaacctcgg gaagaacagt ataattccac ctatagagtc 2280 gtgtctgtgc tcaccgtgct ccatcaggat tggctcaatg ggaaagaata caaatgtaaa 2340 gtctctaaca aagccctgcc cgctcctatc gaaaagacaa tctccaaggc caaaggacag 2400 cctcgcgagc ctcaggtcta caccctgcca ccttcccgcg aggaaatgac aaaaaatcag 2460 gtgtcactca cctgtctcgt gaaggggttt tacccctccg acattgccgt cgagtgggag 2520 tccaatggac agcccgagaa caattataag acaacacctc ccgtcctgga ctccgatgga 2580 tcattttttc tgtactccaa gctcaccgtc gataagtcca gatggcagca gggaaatgtc 2640 ttttcctgct ccgtgatgca tgaagctctc cacaatcatt acacacagaa aagcctgtcc 2700 ctgtcccccg gcaagtgact cgag 2724 <210> 73 <211> 2664 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #29 <400> 73 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtcg ggccagccag aagatcttca acggcctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca gcagcaccct gcagagcggc 240 gtgccaagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagg tcctgctgta cccctacacc 360 tttggccagg gcaccaaggt ggaaatcaag agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtggtggtt ctggtggcgg aggatctggc ggtggtggat ctgggggagg tggaagtggt 1380 ggcggtggta gtggtggtgg cggaagcatg cagatttttg tcaagacact gaccgggaaa 1440 acaatcacac tcgaagtcga gccctccgat acaattgaga atgtgaaagc caaaattcag 1500 gacaaagaag ggattcctcc tgatcagcag cggctgattt ttgccggaaa acagctcgaa 1560 gatggacgga ccctgtccga ttacaatatt cagaaagaaa gcaccctcca tctggtcctg 1620 aggctgcggg gaggcgacat tcagatgaca cagtccccca cctccctgtc tgccagcgtg 1680 ggagatcgcg tgaccattac ctgcagagcc tcccagtgga tcggcaacct gctggattgg 1740 tatcagcaga aacctgggga ggctcctaaa ctgctgatct attacgccag cttcctgcag 1800 tccggcgtgc cctctagatt ttccggcgga ggcttcggca cagatttcac actgaccatc 1860 tcatccctgc agcctgaaga ttttgccaca tattattgcc agcaggccaa ccctgccccc 1920 ctgacatttg gacagggaac aaaggtcgag atcaagcgcg agcctaagtc ctgtgacaag 1980 acacacacat gccctccctg cccagcccca gaactgctcg gtggaccctc tgtgtttctg 2040 tttccaccca agcctaagga tacactcatg atctccagaa cacctgaagt gacatgtgtg 2100 gtcgtcgacg tgtcacatga ggatccagaa gtcaagttta actggtatgt ggatggggtc 2160 gaggtgcaca atgccaaaac aaaacctcgg gaagaacagt ataattccac ctatagagtc 2220 gtgtctgtgc tcaccgtgct ccatcaggat tggctcaatg ggaaagaata caaatgtaaa 2280 gtctctaaca aagccctgcc cgctcctatc gaaaagacaa tctccaaggc caaaggacag 2340 cctcgcgagc ctcaggtcta caccctgcca ccttcccgcg aggaaatgac aaaaaatcag 2400 gtgtcactca cctgtctcgt gaaggggttt tacccctccg acattgccgt cgagtgggag 2460 tccaatggac agcccgagaa caattataag acaacacctc ccgtcctgga ctccgatgga 2520 tcattttttc tgtactccaa gctcaccgtc gataagtcca gatggcagca gggaaatgtc 2580 ttttcctgct ccgtgatgca tgaagctctc cacaatcatt acacacagaa aagcctgtcc 2640 ctgtcccccg gcaagtgact cgag 2664 <210> 74 <211> 2352 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #30 <400> 74 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtcg ggccagccag aagatcttca acggcctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca gcagcaccct gcagagcggc 240 gtgccaagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagg tcctgctgta cccctacacc 360 tttggccagg gcaccaaggt ggaaatcaag agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtgacattc agatgacaca gtcccccacc tccctgtctg ccagcgtggg agatcgcgtg 1380 accattacct gcagagcctc ccagtggatc ggcaacctgc tggattggta tcagcagaaa 1440 cctggggagg ctcctaaact gctgatctat tacgccagct tcctgcagtc cggcgtgccc 1500 tctagatttt ccggcggagg cttcggcaca gatttcacac tgaccatctc atccctgcag 1560 cctgaagatt ttgccacata ttattgccag caggccaacc ctgcccccct gacatttgga 1620 cagggaacaa aggtcgagat caagcgcgag cctaagtcct gtgacaagac acacacatgc 1680 cctccctgcc cagccccaga actgctcggt ggaccctctg tgtttctgtt tccacccaag 1740 cctaaggata cactcatgat ctccagaaca cctgaagtga catgtgtggt cgtcgacgtg 1800 tcacatgagg atccagaagt caagtttaac tggtatgtgg atggggtcga ggtgcacaat 1860 gccaaaacaa aacctcggga agaacagtat aattccacct atagagtcgt gtctgtgctc 1920 accgtgctcc atcaggattg gctcaatggg aaagaataca aatgtaaagt ctctaacaaa 1980 gccctgcccg ctcctatcga aaagacaatc tccaaggcca aaggacagcc tcgcgagcct 2040 caggtctaca ccctgccacc ttcccgcgag gaaatgacaa aaaatcaggt gtcactcacc 2100 tgtctcgtga aggggtttta cccctccgac attgccgtcg agtgggagtc caatggacag 2160 cccgagaaca attataagac aacacctccc gtcctggact ccgatggatc attttttctg 2220 tactccaagc tcaccgtcga taagtccaga tggcagcagg gaaatgtctt ttcctgctcc 2280 gtgatgcatg aagctctcca caatcattac acacagaaaa gcctgtccct gtcccccggc 2340 aagtgactcg ag 2352 <210> 75 <211> 2679 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #31 <400> 75 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtcg ggccagccag aagatcttca acggcctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca gcagcaccct gcagagcggc 240 gtgccaagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagg tcctgctgta cccctacacc 360 tttggccagg gcaccaaggt ggaaatcaag agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtggtggtt ctggtggcgg aggatctggc ggtggtggat ctgggggagg tggaagtggt 1380 ggcggtggta gtggtggtgg cggaagcatg cagatttttg tcaagacact gaccgggaaa 1440 acaatcacac tcgaagtcga gccctccgat acaattgaga atgtgaaagc caaaattcag 1500 gacaaagaag ggattcctcc tgatcagcag cggctgattt ttgccggaaa acagctcgaa 1560 gatggacgga ccctgtccga ttacaatatt cagaaagaaa gcaccctcca tctggtcctg 1620 aggctgcggg gaggcggcgg cggcggcagc gacattcaga tgacacagtc ccccacctcc 1680 ctgtctgcca gcgtgggaga tcgcgtgacc attacctgca gagcctccca gtggatcggc 1740 aacctgctgg attggtatca gcagaaacct ggggaggctc ctaaactgct gatctattac 1800 gccagcttcc tgcagtccgg cgtgccctct agattttccg gcggaggctt cggcacagat 1860 ttcacactga ccatctcatc cctgcagcct gaagattttg ccacatatta ttgccagcag 1920 gccaaccctg cccccctgac atttggacag ggaacaaagg tcgagatcaa gcgcgagcct 1980 aagtcctgtg acaagacaca cacatgccct ccctgcccag ccccagaact gctcggtgga 2040 ccctctgtgt ttctgtttcc acccaagcct aaggatacac tcatgatctc cagaacacct 2100 gaagtgacat gtgtggtcgt cgacgtgtca catgaggatc cagaagtcaa gtttaactgg 2160 tatgtggatg gggtcgaggt gcacaatgcc aaaacaaaac ctcgggaaga acagtataat 2220 tccacctata gagtcgtgtc tgtgctcacc gtgctccatc aggattggct caatgggaaa 2280 gaatacaaat gtaaagtctc taacaaagcc ctgcccgctc ctatcgaaaa gacaatctcc 2340 aaggccaaag gacagcctcg cgagcctcag gtctacaccc tgccaccttc ccgcgaggaa 2400 atgacaaaaa atcaggtgtc actcacctgt ctcgtgaagg ggttttaccc ctccgacatt 2460 gccgtcgagt gggagtccaa tggacagccc gagaacaatt ataagacaac acctcccgtc 2520 ctggactccg atggatcatt ttttctgtac tccaagctca ccgtcgataa gtccagatgg 2580 cagcagggaa atgtcttttc ctgctccgtg atgcatgaag ctctccacaa tcattacaca 2640 cagaaaagcc tgtccctgtc ccccggcaag tgactcgag 2679 <210> 76 <211> 2670 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #32 <400> 76 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtcg ggccagccag aagatcttca acggcctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca gcagcaccct gcagagcggc 240 gtgccaagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagg tcctgctgta cccctacacc 360 tttggccagg gcaccaaggt ggaaatcaag agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtggtggtt ctggtggcgg aggatctggc ggtggtggat ctgggggagg tggaagtggt 1380 ggcggtggta gtggtggtgg cggaagcatg cagatttttg tcaagacact gaccgggaaa 1440 acaatcacac tcgaagtcga gccctccgat acaattgaga atgtgaaagc caaaattcag 1500 gacaaagaag ggattcctcc tgatcagcag cggctgattt ttgccggaaa acagctcgaa 1560 gatggacgga ccctgtccga ttacaatatt cagaaagaaa gcaccctcca tctggtcctg 1620 aggctgcggg gaggcggcgg cgacattcag atgacacagt cccccacctc cctgtctgcc 1680 agcgtgggag atcgcgtgac cattacctgc agagcctccc agtggatcgg caacctgctg 1740 gattggtatc agcagaaacc tggggaggct cctaaactgc tgatctatta cgccagcttc 1800 ctgcagtccg gcgtgccctc tagattttcc ggcggaggct tcggcacaga tttcacactg 1860 accatctcat ccctgcagcc tgaagatttt gccacatatt attgccagca ggccaaccct 1920 gcccccctga catttggaca gggaacaaag gtcgagatca agcgcgagcc taagtcctgt 1980 gacaagacac acacatgccc tccctgccca gccccagaac tgctcggtgg accctctgtg 2040 tttctgtttc cacccaagcc taaggataca ctcatgatct ccagaacacc tgaagtgaca 2100 tgtgtggtcg tcgacgtgtc acatgaggat ccagaagtca agtttaactg gtatgtggat 2160 ggggtcgagg tgcacaatgc caaaacaaaa cctcgggaag aacagtataa ttccacctat 2220 agagtcgtgt ctgtgctcac cgtgctccat caggattggc tcaatgggaa agaatacaaa 2280 tgtaaagtct ctaacaaagc cctgcccgct cctatcgaaa agacaatctc caaggccaaa 2340 ggacagcctc gcgagcctca ggtctacacc ctgccacctt cccgcgagga aatgacaaaa 2400 aatcaggtgt cactcacctg tctcgtgaag gggttttacc cctccgacat tgccgtcgag 2460 tgggagtcca atggacagcc cgagaacaat tataagacaa cacctcccgt cctggactcc 2520 gatggatcat tttttctgta ctccaagctc accgtcgata agtccagatg gcagcaggga 2580 aatgtctttt cctgctccgt gatgcatgaa gctctccaca atcattacac acagaaaagc 2640 ctgtccctgt cccccggcaa gtgactcgag 2670 <210> 77 <211> 2679 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #33 <400> 77 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtcg ggccagccag aagatcttca acggcctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca gcagcaccct gcagagcggc 240 gtgccaagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagg tcctgctgta cccctacacc 360 tttggccagg gcaccaaggt ggaaatcaag agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtggtggtt ctggtggcgg aggatctggc ggtggtggat ctgggggagg tggaagtggt 1380 ggcggtggta gtggtggtgg cggaagcatg cagatttttg tcaagacact gaccgggaaa 1440 acaatcacac tcgaagtcga gccctccgat acaattgaga atgtgaaagc caaaattcag 1500 gacaaagaag ggattcctcc tgatcagcag cggctgattt ttgccggaaa acagctcgaa 1560 gatggacgga ccctgtccga ttacaatatt cagaaagaaa gcaccctcca tctggtcctg 1620 aggctgcggg gaggcggcgg cggcggcagc gacattcaga tgacacagtc ccccacctcc 1680 ctgtctgcca gcgtgggaga tcgcgtgacc attacctgca gagcctccca gtggatcggc 1740 aacctgctgg attggtatca gcagaaacct ggggaggctc ctaaactgct gatctattac 1800 gccagcttcc tgcagtccgg cgtgccctct agattttccg gcggaggctt cggcacagat 1860 ttcacactga ccatctcatc cctgcagcct gaagattttg ccacatatta ttgccagcag 1920 gccaaccctg cccccctgac atttggacag ggaacaaagg tcgagatcaa gcgcgagcct 1980 aagtcctgtg acaagacaca cacatgccct ccctgcccag ccccagaact gctcggtgga 2040 ccctctgtgt ttctgtttcc acccaagcct aaggatacac tcatgatctc cagaacacct 2100 gaagtgacat gtgtggtcgt cgacgtgtca catgaggatc cagaagtcaa gtttaactgg 2160 tatgtggatg gggtcgaggt gcacaatgcc aaaacaaaac ctcgggaaga acagtataat 2220 tccacctata gagtcgtgtc tgtgctcacc gtgctccatc aggattggct caatgggaaa 2280 gaatacaaat gtaaagtctc taacaaagcc ctgcccgctc ctatcgaaaa gacaatctcc 2340 aaggccaaag gacagcctcg cgagcctcag gtctacaccc tgccaccttc ccgcgaggaa 2400 atgacaaaaa atcaggtgtc actcacctgt ctcgtgaagg ggttttaccc ctccgacatt 2460 gccgtcgagt gggagtccaa tggacagccc gagaacaatt ataagacaac acctcccgtc 2520 ctggactccg atggatcatt ttttctgtac tccaagctca ccgtcgataa gtccagatgg 2580 cagcagggaa atgtcttttc ctgctccgtg atgcatgaag ctctccacaa tcattacaca 2640 cagaaaagcc tgtccctgtc ccccggcaag tgactcgag 2679 <210> 78 <211> 2352 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #34 <400> 78 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtcg ggccagccag aagatcttca acggcctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca gcagcaccct gcagagcggc 240 gtgccaagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagg tcctgctgta cccctacacc 360 tttggccagg gcaccaaggt ggaaatcaag agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtgacattc agatgacaca gtcccccacc tccctgtctg ccagcgtggg agatcgcgtg 1380 accattacct gcagagcctc ccagtggatc ggcaacctgc tggattggta tcagcagaaa 1440 cctggggagg ctcctaaact gctgatctat tacgccagct tcctgcagtc cggcgtgccc 1500 tctagatttt ccggcggagg cttcggcaca gatttcacac tgaccatctc atccctgcag 1560 cctgaagatt ttgccacata ttattgccag caggccaacc ctgcccccct gacatttgga 1620 cagggaacaa aggtcgagat caagcgcgag cctaagtcct gtgacaagac acacacatgc 1680 cctccctgcc cagccccaga actgctcggt ggaccctctg tgtttctgtt tccacccaag 1740 cctaaggata cactcatgat ctccagaaca cctgaagtga catgtgtggt cgtcgacgtg 1800 tcacatgagg atccagaagt caagtttaac tggtatgtgg atggggtcga ggtgcacaat 1860 gccaaaacaa aacctcggga agaacagtat aattccacct atagagtcgt gtctgtgctc 1920 accgtgctcc atcaggattg gctcaatggg aaagaataca aatgtaaagt ctctaacaaa 1980 gccctgcccg ctcctatcga aaagacaatc tccaaggcca aaggacagcc tcgcgagcct 2040 caggtctaca ccctgccacc ttcccgcgag gaaatgacaa aaaatcaggt gtcactcacc 2100 tgtctcgtga aggggtttta cccctccgac attgccgtcg agtgggagtc caatggacag 2160 cccgagaaca attataagac aacacctccc gtcctggact ccgatggatc attttttctg 2220 tactccaagc tcaccgtcga taagtccaga tggcagcagg gaaatgtctt ttcctgctcc 2280 gtgatgcatg aagctctcca caatcattac acacagaaaa gcctgtccct gtcccccggc 2340 aagtgactcg ag 2352 <210> 79 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #33 <400> 79 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtcg ggccagccag aagatcttca acggcctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca gcagcaccct gcagagcggc 240 gtgccaagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagg tcctgctgta cccctacacc 360 tttggccagg gcaccaaggt ggaaatcaag agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaaga tgcagatctt cgtgaaaacc ctgaccggca agaccatcac cctggaagtg 1140 gaacccagcg acaccatcga gaacgtgaag gccaagatcc aggacaaaga gggcatcccc 1200 cccgaccagc agagactgat cttcgccggc aagcagctgg aagatggcag aaccctgagc 1260 gactacaaca tccagaaaga gtccaccctg cacctggtgc tgcggctgag aggcggaggt 1320 ggtggtggtt ctgacattca gatgacacag tcccccacct ccctgtctgc cagcgtggga 1380 gatcgcgtga ccattacctg cagagcctcc cagtggatcg gcaacctgct ggattggtat 1440 cagcagaaac ctggggaggc tcctaaactg ctgatctatt acgccagctt cctgcagtcc 1500 ggcgtgccct ctagattttc cggcggaggc ttcggcacag atttcacact gaccatctca 1560 tccctgcagc ctgaagattt tgccacatat tattgccagc aggccaaccc tgcccccctg 1620 acatttggac agggaacaaa ggtcgagatc aagcgcgagc ctaagtcctg tgacaagaca 1680 cacacatgcc ctccctgccc agccccagaa ctgctcggtg gaccctctgt gtttctgttt 1740 ccacccaagc ctaaggatac actcatgatc tccagaacac ctgaagtgac atgtgtggtc 1800 gtcgacgtgt cacatgagga tccagaagtc aagtttaact ggtatgtgga tggggtcgag 1860 gtgcacaatg ccaaaacaaa acctcgggaa gaacagtata attccaccta tagagtcgtg 1920 tctgtgctca ccgtgctcca tcaggattgg ctcaatggga aagaatacaa atgtaaagtc 1980 tctaacaaag ccctgcccgc tcctatcgaa aagacaatct ccaaggccaa aggacagcct 2040 cgcgagcctc aggtctacac cctgccacct tcccgcgagg aaatgacaaa aaatcaggtg 2100 tcactcacct gtctcgtgaa ggggttttac ccctccgaca ttgccgtcga gtgggagtcc 2160 aatggacagc ccgagaacaa ttataagaca acacctcccg tcctggactc cgatggatca 2220 ttttttctgt actccaagct caccgtcgat aagtccagat ggcagcaggg aaatgtcttt 2280 tcctgctccg tgatgcatga agctctccac aatcattaca cacagaaaag cctgtccctg 2340 tcccccggca agtgactcga g 2361 <210> 80 <211> 2496 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #36 <400> 80 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtcg ggccagccag aagatcttca acggcctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca gcagcaccct gcagagcggc 240 gtgccaagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagg tcctgctgta cccctacacc 360 tttggccagg gcaccaaggt ggaaatcaag agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaagg gcggcatgaa gcgccagggc aaggagatgg acagcctgcg cttcctgtac 1140 gacggcatcc gcatccaggc cgaccaggcc cccgaggacc tggacatgga ggacaacgac 1200 atcatcgagg cccaccgcga gcagatcggc ggcggtggtg gtggttctgg tggcggagga 1260 tctggcggtg gtggatctgg gggaggtgga agtggtggcg gtggtagtgg tggtggcgga 1320 agcatgaagc gccagggcaa ggagatggac agcctgcgct tcctgtacga cggcatccgc 1380 atccaggccg accaggcccc cgaggacctg gacatggagg acaacgacat catcgaggcc 1440 caccgcgagc agatcggcgg cggcggcgac attcagatga cacagtcccc cacctccctg 1500 tctgccagcg tgggagatcg cgtgaccatt acctgcagag cctcccagtg gatcggcaac 1560 ctgctggatt ggtatcagca gaaacctggg gaggctccta aactgctgat ctattacgcc 1620 agcttcctgc agtccggcgt gccctctaga ttttccggcg gaggcttcgg cacagatttc 1680 acactgacca tctcatccct gcagcctgaa gattttgcca catattattg ccagcaggcc 1740 aaccctgccc ccctgacatt tggacaggga acaaaggtcg agatcaagcg cgagcctaag 1800 tcctgtgaca agacacacac atgccctccc tgcccagccc cagaactgct cggtggaccc 1860 tctgtgtttc tgtttccacc caagcctaag gatacactca tgatctccag aacacctgaa 1920 gtgacatgtg tggtcgtcga cgtgtcacat gaggatccag aagtcaagtt taactggtat 1980 gtggatgggg tcgaggtgca caatgccaaa acaaaacctc gggaagaaca gtataattcc 2040 acctatagag tcgtgtctgt gctcaccgtg ctccatcagg attggctcaa tgggaaagaa 2100 tacaaatgta aagtctctaa caaagccctg cccgctccta tcgaaaagac aatctccaag 2160 gccaaaggac agcctcgcga gcctcaggtc tacaccctgc caccttcccg cgaggaaatg 2220 acaaaaaatc aggtgtcact cacctgtctc gtgaaggggt tttacccctc cgacattgcc 2280 gtcgagtggg agtccaatgg acagcccgag aacaattata agacaacacc tcccgtcctg 2340 gactccgatg gatcattttt tctgtactcc aagctcaccg tcgataagtc cagatggcag 2400 cagggaaatg tcttttcctg ctccgtgatg catgaagctc tccacaatca ttacacacag 2460 aaaagcctgt ccctgtcccc cggcaagtga ctcgag 2496 <210> 81 <211> 2280 <212> DNA <213> Artificial Sequence <220> <223> Nucleotide sequence encoding the protein complex comprising VEGF and EGFR specific binding peptides #37 <400> 81 gaattcgcca ccatgggctg gtcctgcatc atcctgtttc tggtggccac cgccaccggc 60 gtgcactctg atatccagat gacccagagc cccagcagcc tgtctgcctc tgtgggcgac 120 agagtgacca tcacctgtcg ggccagccag aagatcttca acggcctgag ctggtatcag 180 cagaagcccg gcaaggcccc caagctgctg atctaccaca gcagcaccct gcagagcggc 240 gtgccaagca gattttctgg cagcggcagc ggcaccgact tcaccctgac aatcagcagc 300 ctgcagcccg aggacttcgc cacctactac tgccagcagg tcctgctgta cccctacacc 360 tttggccagg gcaccaaggt ggaaatcaag agagagccca agagctgcga caagacccac 420 acctgtcccc cttgtcctgc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc 480 ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg 540 gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg 600 cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc 660 gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc 720 aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagcccaga 780 gaaccccagg tgtacacact gccccccagc agagaagaga tgaccaagaa ccaggtgtcc 840 ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac 900 ggccagcctg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc 960 ttcctgtaca gcaagctgac cgtggacaag agccggtggc agcagggcaa cgtgttcagc 1020 tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc 1080 cccggcaagg actacgacat ccccaccacc gagaacctgt acttccaggg cggtggtggt 1140 ggttctggtg gcggaggatc tggcggtggt ggatctgggg gaggtggaag tggtggcggt 1200 ggtagtggtg gtggcggaag cgagaacctg tacttccagg gctctggcgg cgacattcag 1260 atgacacagt cccccacctc cctgtctgcc agcgtgggag atcgcgtgac cattacctgc 1320 agagcctccc agtggatcgg caacctgctg gattggtatc agcagaaacc tggggaggct 1380 cctaaactgc tgatctatta cgccagcttc ctgcagtccg gcgtgccctc tagattttcc 1440 ggcggaggct tcggcacaga tttcacactg accatctcat ccctgcagcc tgaagatttt 1500 gccacatatt attgccagca ggccaaccct gcccccctga catttggaca gggaacaaag 1560 gtcgagatca agcgcgagcc taagtcctgt gacaagacac acacatgccc tccctgccca 1620 gccccagaac tgctcggtgg accctctgtg tttctgtttc cacccaagcc taaggataca 1680 ctcatgatct ccagaacacc tgaagtgaca tgtgtggtcg tcgacgtgtc acatgaggat 1740 ccagaagtca agtttaactg gtatgtggat ggggtcgagg tgcacaatgc caaaacaaaa 1800 cctcgggaag aacagtataa ttccacctat agagtcgtgt ctgtgctcac cgtgctccat 1860 caggattggc tcaatgggaa agaatacaaa tgtaaagtct ctaacaaagc cctgcccgct 1920 cctatcgaaa agacaatctc caaggccaaa ggacagcctc gcgagcctca ggtctacacc 1980 ctgccacctt cccgcgagga aatgacaaaa aatcaggtgt cactcacctg tctcgtgaag 2040 gggttttacc cctccgacat tgccgtcgag tgggagtcca atggacagcc cgagaacaat 2100 tataagacaa cacctcccgt cctggactcc gatggatcat tttttctgta ctccaagctc 2160 accgtcgata agtccagatg gcagcaggga aatgtctttt cctgctccgt gatgcatgaa 2220 gctctccaca atcattacac acagaaaagc ctgtccctgt cccccggcaa gtgactcgag 2280 2280

Claims (18)

  1. 항원 결합 부위를 포함하는 2 이상의 폴리펩티드; 및 상기 2 이상의 폴리펩티드를 서로 연결하는 링커를 포함하는 것으로서, 상기 링커는 양 말단 중 적어도 하나의 말단에 태그를 포함하고, 상기 태그는 상기 폴리펩티드의 말단에 연결되며, 절단 가능한 아미노산 서열을 포함하는 것인 단백질 복합체.
  2. 제1항에 있어서, 상기 항원 결합 부위는 상기 폴리펩티드의 N-말단에 위치하는 것인 단백질 복합체.
  3. 제1항에 있어서, 상기 2 이상의 폴리펩티드는 서로 동일하거나, 서로 다른 항원 결합 부위를 갖는 것인 단백질 복합체.
  4. 제1항에 있어서, 상기 단백질 복합체는 N-말단에 제1 항원 결합 부위를 포함하는 제1 폴리펩티드; N-말단에 제2 항원 결합 부위를 포함하는 제2 폴리펩티드; 및 상기 제1 폴리펩티드 및 제2 폴리펩티드를 서로 연결하는 링커를 포함하는 것으로서, 상기 링커는 양 말단에 제1 태그 및 제2 태그를 포함하고, 상기 제1 태그는 상기 제1 폴리펩티드의 C-말단에, 상기 제2 태그는 상기 제2 폴리펩티드의 N-말단에 연결되며, 상기 제1 태그 및 제2 태그는 각각 절단 가능한 아미노산 서열을 포함하는 것인 단백질 복합체.
  5. 제1항에 있어서, 상기 단백질 복합체는 N-말단에 제1 항원 결합 부위를 포함하는 제1 폴리펩티드; N-말단에 제2 항원 결합 부위를 포함하는 제2 폴리펩티드; 및 상기 제1 폴리펩티드 및 제2 폴리펩티드를 서로 연결하는 링커를 포함하는 것으로서, 상기 링커는 하나의 말단에 태그를 포함하고, 상기 태그는 상기 제1 폴리펩티드의 C-말단 또는 상기 제2 폴리펩티드의 N-말단에 연결되며, 절단 가능한 아미노산 서열을 포함하는 것인 단백질 복합체.
  6. 제1항에 있어서, 상기 항원 결합 부위를 포함하는 폴리펩티드는 Fab, Fab', Fv 및 scFv로 이루어진 군으로부터 선택되는 항체 단편의 중쇄(heavy chain) 또는 단쇄(light chain) 또는 단일-도메인 항체(single-domain antibody)인 것인 단백질 복합체.
  7. 제1항에 있어서, 상기 태그는 유비퀴틴, 유비퀴틴-유사 단백질 및 TEV 절단 펩티드(TEV cleavage peptide) 및 퓨린(furin) 절단 펩티드로 이루어진 군으로부터 선택되는 것인 단백질 복합체.
  8. 제1항에 있어서, 상기 태그는 상기 폴리펩티드의 N-말단 또는 C-말단에 연결된 것인 단백질 복합체.
  9. 제1항에 있어서, 상기 링커는 1 내지 100개의 임의의 아미노산으로 이루어진 폴리펩티드인 것인 단백질 복합체.
  10. 제1항에 있어서, 상기 폴리펩티드는 서열번호 8 내지 서열번호 44로 이루어진 군으로부터 선택되는 아미노산 서열을 갖는 것인 단백질 복합체.
  11. 항원 결합 부위를 포함하는 2 이상의 폴리펩티드; 및 상기 2 이상의 폴리펩티드를 서로 연결하는 링커를 포함하는 것으로서, 상기 링커는 양 말단 중 적어도 하나의 말단에 태그를 포함하고, 상기 태그는 상기 폴리펩티드의 말단에 연결되며, 절단 가능한 아미노산 서열을 포함하는 것인 단백질 복합체를 코딩하는 폴리뉴클레오티드.
  12. 제11항에 있어서, 상기 폴리뉴클레오티드는 서열번호 45 내지 서열번호 81로 이루어진 군으로부터 선택되는 염기서열을 갖는 것인 폴리뉴클레오티드.
  13. 항원 결합 부위를 포함하는 2 이상의 폴리펩티드; 및 상기 2 이상의 폴리펩티드를 서로 연결하는 링커를 포함하는 것으로서, 상기 링커는 양 말단 중 적어도 하나의 말단에 태그를 포함하고, 상기 태그는 상기 폴리펩티드의 말단에 연결되며, 절단 가능한 아미노산 서열을 포함하는 것인 단백질 복합체를 코딩하는 폴리뉴클레오티드 및 상기 폴리뉴클레오티드에 작동적으로 연결된(operatively linked) 프로모터를 포함하는 재조합 벡터.
  14. 항원 결합 부위를 포함하는 2 이상의 폴리펩티드; 및 상기 2 이상의 폴리펩티드를 서로 연결하는 링커를 포함하는 것으로서, 상기 링커는 양 말단 중 적어도 하나의 말단에 태그를 포함하고, 상기 태그는 상기 폴리펩티드의 말단에 연결되며, 절단 가능한 아미노산 서열을 포함하는 것인 단백질 복합체를 코딩하는 폴리뉴클레오티드 및 상기 폴리뉴클레오티드에 작동적으로 연결된 프로모터를 포함하는 재조합 벡터를 포함하는 숙주세포.
  15. 항원 결합 부위를 포함하는 2 이상의 폴리펩티드; 및 상기 2 이상의 폴리펩티드를 서로 연결하는 링커를 포함하는 것으로서, 상기 링커는 양 말단 중 적어도 하나의 말단에 태그를 포함하고, 상기 태그는 상기 폴리펩티드의 말단에 연결되며, 절단 가능한 아미노산 서열을 포함하는 것인 단백질 복합체를 코딩하는 폴리뉴클레오티드 및 상기 폴리뉴클레오티드에 작동적으로 연결된 프로모터를 포함하는 재조합 벡터를 발현시켜 상기 단백질 복합체를 생산하는 단계를 포함하는 다중특이 항체의 제조 방법.
  16. 제15항에 있어서, 상기 생산하는 단계 이후, 상기 태그를 절단시키는 단계를 더 포함하는 것인 방법.
  17. 제16항에 있어서, 상기 절단시키는 단계는 태그에 포함된 절단 가능한 아미노산 서열을 인식하는 프로테아제를 첨가하여 절단시키는 것인 방법.
  18. 제15항에 있어서, 상기 태그는 유비퀴틴, 유비퀴틴-유사 단백질, TEV 절단 펩티드 및 퓨린 절단 펩티드로 이루어진 군으로부터 선택되는 것인 방법.
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