KR20130041944A - 베타-아밀로이드 생성의 감소를 위한 화합물 - Google Patents
베타-아밀로이드 생성의 감소를 위한 화합물 Download PDFInfo
- Publication number
- KR20130041944A KR20130041944A KR1020137003728A KR20137003728A KR20130041944A KR 20130041944 A KR20130041944 A KR 20130041944A KR 1020137003728 A KR1020137003728 A KR 1020137003728A KR 20137003728 A KR20137003728 A KR 20137003728A KR 20130041944 A KR20130041944 A KR 20130041944A
- Authority
- KR
- South Korea
- Prior art keywords
- cyclopenta
- methyl
- metheno
- azeno
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- IPFZARHKKQXZPN-UHFFFAOYSA-N Clc1c(CCC2c3ccccc3)c2nc(Cl)n1 Chemical compound Clc1c(CCC2c3ccccc3)c2nc(Cl)n1 IPFZARHKKQXZPN-UHFFFAOYSA-N 0.000 description 2
- IMRGDAMIJUWQRK-UHFFFAOYSA-N CC(C)(C)OC(N(C)CCCOc1cc([N+]([O-])=O)ccc1-[n]1cnc(Cl)c1)=O Chemical compound CC(C)(C)OC(N(C)CCCOc1cc([N+]([O-])=O)ccc1-[n]1cnc(Cl)c1)=O IMRGDAMIJUWQRK-UHFFFAOYSA-N 0.000 description 1
- HBFNEQHBPPNHEG-UHFFFAOYSA-N CC(C)(C)OC(N(CCc1c(CCC2c(cc3)ccc3F)c2nc(Cl)n1)CCOc(cc(cc1)N)c1C#N)=O Chemical compound CC(C)(C)OC(N(CCc1c(CCC2c(cc3)ccc3F)c2nc(Cl)n1)CCOc(cc(cc1)N)c1C#N)=O HBFNEQHBPPNHEG-UHFFFAOYSA-N 0.000 description 1
- SFQNGWBUTJUOGS-UHFFFAOYSA-N CC(C)(C)OC(NCCCOc(cc(cc1)[N+]([O-])=O)c1-[n]1nc(C)nc1)=O Chemical compound CC(C)(C)OC(NCCCOc(cc(cc1)[N+]([O-])=O)c1-[n]1nc(C)nc1)=O SFQNGWBUTJUOGS-UHFFFAOYSA-N 0.000 description 1
- IFYPGGQCKJUNTN-UHFFFAOYSA-N CCOC(C(CN)c(cc1)ccc1F)=O Chemical compound CCOC(C(CN)c(cc1)ccc1F)=O IFYPGGQCKJUNTN-UHFFFAOYSA-N 0.000 description 1
- JBYAYYWUYHVQNV-XVNBXDOJSA-N CN(CC/C=C/COc(cc(cc1)N2)c1-[n]1cnc(Cl)c1)c1c(CCC3c4ccccc4)c3nc2n1 Chemical compound CN(CC/C=C/COc(cc(cc1)N2)c1-[n]1cnc(Cl)c1)c1c(CCC3c4ccccc4)c3nc2n1 JBYAYYWUYHVQNV-XVNBXDOJSA-N 0.000 description 1
- JBYAYYWUYHVQNV-CLTKARDFSA-N CN(CC/C=C\COc(cc(cc1)N2)c1-[n]1cnc(Cl)c1)c1c(CCC3c4ccccc4)c3nc2n1 Chemical compound CN(CC/C=C\COc(cc(cc1)N2)c1-[n]1cnc(Cl)c1)c1c(CCC3c4ccccc4)c3nc2n1 JBYAYYWUYHVQNV-CLTKARDFSA-N 0.000 description 1
- VAKCEOAWBGPABY-UHFFFAOYSA-N CN(CC=C)c1c(CCC2c(c(F)c3)ccc3F)c2nc(Nc(cc2)cc(OCC=C)c2C#N)n1 Chemical compound CN(CC=C)c1c(CCC2c(c(F)c3)ccc3F)c2nc(Nc(cc2)cc(OCC=C)c2C#N)n1 VAKCEOAWBGPABY-UHFFFAOYSA-N 0.000 description 1
- YUXIGXOPZVKTOH-UHFFFAOYSA-N CN(CC=C)c1c(CCC2c(cc3)ccc3F)c2nc(Cl)n1 Chemical compound CN(CC=C)c1c(CCC2c(cc3)ccc3F)c2nc(Cl)n1 YUXIGXOPZVKTOH-UHFFFAOYSA-N 0.000 description 1
- KAPCIXQNVQHZLW-UHFFFAOYSA-N CN(CC=C)c1c(CN(C)CC2c(cc3)ccc3F)c2nc(Cl)n1 Chemical compound CN(CC=C)c1c(CN(C)CC2c(cc3)ccc3F)c2nc(Cl)n1 KAPCIXQNVQHZLW-UHFFFAOYSA-N 0.000 description 1
- YRSNATRWTBJOPY-UHFFFAOYSA-N CN(CCC=C)c1c(CCC2c3ccccc3)c2nc(Cl)n1 Chemical compound CN(CCC=C)c1c(CCC2c3ccccc3)c2nc(Cl)n1 YRSNATRWTBJOPY-UHFFFAOYSA-N 0.000 description 1
- ITBDJIUGLNMGPV-UHFFFAOYSA-N CN(CCCOc(cc(cc1)N2)c1-[n]1cnc(Cl)c1)c1c(CCC3c4ccccc4)c3nc2n1 Chemical compound CN(CCCOc(cc(cc1)N2)c1-[n]1cnc(Cl)c1)c1c(CCC3c4ccccc4)c3nc2n1 ITBDJIUGLNMGPV-UHFFFAOYSA-N 0.000 description 1
- VBUZSYHLXLXIGY-UHFFFAOYSA-N CN(CCCOc(cc(cc1)N2)c1C#N)c1c(CCC3c(c(F)c4)ccc4F)c3nc2n1 Chemical compound CN(CCCOc(cc(cc1)N2)c1C#N)c1c(CCC3c(c(F)c4)ccc4F)c3nc2n1 VBUZSYHLXLXIGY-UHFFFAOYSA-N 0.000 description 1
- FVAUDXXLLJKCRN-UHFFFAOYSA-N CN(CCCOc(cc(cc1)[N+]([O-])=O)c1-[n]1cnc(Cl)c1)c1c(CCC2c(c(F)c3)ccc3F)c2nc(Cl)n1 Chemical compound CN(CCCOc(cc(cc1)[N+]([O-])=O)c1-[n]1cnc(Cl)c1)c1c(CCC2c(c(F)c3)ccc3F)c2nc(Cl)n1 FVAUDXXLLJKCRN-UHFFFAOYSA-N 0.000 description 1
- PTHSWFMGJOVVSO-UHFFFAOYSA-N COc1c(CCC2c3ccccc3)c2nc(OC)n1 Chemical compound COc1c(CCC2c3ccccc3)c2nc(OC)n1 PTHSWFMGJOVVSO-UHFFFAOYSA-N 0.000 description 1
- CCJWWRKISQTFKB-UHFFFAOYSA-N COc1nc(OC)nc2c1CC=C2c1ccccc1 Chemical compound COc1nc(OC)nc2c1CC=C2c1ccccc1 CCJWWRKISQTFKB-UHFFFAOYSA-N 0.000 description 1
- PCZNNASJRYMEBP-UHFFFAOYSA-N Cc(nc1)n[n]1-c(c(OCC=C)c1)ccc1Nc1nc(NCC=C)c(CCC2c(cc3)ccc3F)c2n1 Chemical compound Cc(nc1)n[n]1-c(c(OCC=C)c1)ccc1Nc1nc(NCC=C)c(CCC2c(cc3)ccc3F)c2n1 PCZNNASJRYMEBP-UHFFFAOYSA-N 0.000 description 1
- QVYHIGAXZNKYRJ-UHFFFAOYSA-N Cc(nc1)n[n]1-c(ccc(N)c1)c1OCCN(C)CCNc1c(CCC2c(cc3)ccc3F)c2nc(Cl)n1 Chemical compound Cc(nc1)n[n]1-c(ccc(N)c1)c1OCCN(C)CCNc1c(CCC2c(cc3)ccc3F)c2nc(Cl)n1 QVYHIGAXZNKYRJ-UHFFFAOYSA-N 0.000 description 1
- XMTQNKNYWCKRPU-UHFFFAOYSA-N Cc(nc1)n[n]1-c(ccc(Nc1nc(CCC=C)c(CCC2c3ccccc3)c2n1)c1)c1OCC=C Chemical compound Cc(nc1)n[n]1-c(ccc(Nc1nc(CCC=C)c(CCC2c3ccccc3)c2n1)c1)c1OCC=C XMTQNKNYWCKRPU-UHFFFAOYSA-N 0.000 description 1
- ZVVTVDHBARQCCF-UHFFFAOYSA-N Cc(nc1)n[n]1-c(ccc(Nc1nc(NCC=C)c(CCC2c3ccccc3)c2n1)c1)c1OCC=C Chemical compound Cc(nc1)n[n]1-c(ccc(Nc1nc(NCC=C)c(CCC2c3ccccc3)c2n1)c1)c1OCC=C ZVVTVDHBARQCCF-UHFFFAOYSA-N 0.000 description 1
- XOPKOHKWASKCSF-UHFFFAOYSA-N Cc(nc1)n[n]1-c(ccc([N+]([O-])=O)c1)c1OCCN(C)CCNc1c(CCC2c(cc3)ccc3F)c2nc(Cl)n1 Chemical compound Cc(nc1)n[n]1-c(ccc([N+]([O-])=O)c1)c1OCCN(C)CCNc1c(CCC2c(cc3)ccc3F)c2nc(Cl)n1 XOPKOHKWASKCSF-UHFFFAOYSA-N 0.000 description 1
- KJOGUTLHJFIJGO-QHHAFSJGSA-N Clc(nc1)c[n]1-c(ccc(N1)c2)c2OC/C=C/CCc2c(CCC3c4ccccc4)c3nc1n2 Chemical compound Clc(nc1)c[n]1-c(ccc(N1)c2)c2OC/C=C/CCc2c(CCC3c4ccccc4)c3nc1n2 KJOGUTLHJFIJGO-QHHAFSJGSA-N 0.000 description 1
- HVMOTPDQBXKUPB-UHFFFAOYSA-N Clc(nc1)c[n]1-c(ccc(N1)c2)c2OCCCCCc2c(CCC3c4ccccc4)c3nc1n2 Chemical compound Clc(nc1)c[n]1-c(ccc(N1)c2)c2OCCCCCc2c(CCC3c4ccccc4)c3nc1n2 HVMOTPDQBXKUPB-UHFFFAOYSA-N 0.000 description 1
- VKXBTUYGBMLRQR-QHHAFSJGSA-N N#Cc(ccc(N1)c2)c2OC/C=C/CCc2c(CCC3c4ccccc4)c3nc1n2 Chemical compound N#Cc(ccc(N1)c2)c2OC/C=C/CCc2c(CCC3c4ccccc4)c3nc1n2 VKXBTUYGBMLRQR-QHHAFSJGSA-N 0.000 description 1
- GOQPGHPDMIWJAR-UHFFFAOYSA-N N#Cc(ccc(N1)c2)c2OCCCCCc2c(CCC3c4ccccc4)c3nc1n2 Chemical compound N#Cc(ccc(N1)c2)c2OCCCCCc2c(CCC3c4ccccc4)c3nc1n2 GOQPGHPDMIWJAR-UHFFFAOYSA-N 0.000 description 1
- FRLKFUGUOABFFD-UHFFFAOYSA-N N#Cc(ccc([N+]([O-])=O)c1)c1OCCCNc1c(CCC2c(c(F)c3)ccc3F)c2nc(Cl)n1 Chemical compound N#Cc(ccc([N+]([O-])=O)c1)c1OCCCNc1c(CCC2c(c(F)c3)ccc3F)c2nc(Cl)n1 FRLKFUGUOABFFD-UHFFFAOYSA-N 0.000 description 1
- KTHIGOYNYOEIOH-UHFFFAOYSA-N N#Cc(ccc([N+]([O-])=O)c1)c1OCCNCCNc1c(CCC2c(cc3)ccc3F)c2nc(Cl)n1 Chemical compound N#Cc(ccc([N+]([O-])=O)c1)c1OCCNCCNc1c(CCC2c(cc3)ccc3F)c2nc(Cl)n1 KTHIGOYNYOEIOH-UHFFFAOYSA-N 0.000 description 1
- AJXWMSPTSJWPLB-UHFFFAOYSA-N NCCCCOc1cc([N+]([O-])=O)ccc1C#N Chemical compound NCCCCOc1cc([N+]([O-])=O)ccc1C#N AJXWMSPTSJWPLB-UHFFFAOYSA-N 0.000 description 1
- LGIOLLIKWYLWKG-UHFFFAOYSA-N NCCCOc(cc(cc1)[N+]([O-])=O)c1-[n]1cnc(Cl)c1 Chemical compound NCCCOc(cc(cc1)[N+]([O-])=O)c1-[n]1cnc(Cl)c1 LGIOLLIKWYLWKG-UHFFFAOYSA-N 0.000 description 1
- XTQDGNUEEGADGZ-UHFFFAOYSA-N NCCOc(cc(cc1)[N+]([O-])=O)c1C#N Chemical compound NCCOc(cc(cc1)[N+]([O-])=O)c1C#N XTQDGNUEEGADGZ-UHFFFAOYSA-N 0.000 description 1
- QFEIITSWPXZAQX-UHFFFAOYSA-N Nc(cc1)cc(OCCCNc2c(CCC3c(c(F)c4)ccc4F)c3nc(Cl)n2)c1C#N Chemical compound Nc(cc1)cc(OCCCNc2c(CCC3c(c(F)c4)ccc4F)c3nc(Cl)n2)c1C#N QFEIITSWPXZAQX-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36442510P | 2010-07-15 | 2010-07-15 | |
| US61/364,425 | 2010-07-15 | ||
| PCT/US2011/043628 WO2012009309A1 (en) | 2010-07-15 | 2011-07-12 | Compounds for the reduction of beta-amyloid production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20130041944A true KR20130041944A (ko) | 2013-04-25 |
Family
ID=44511486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020137003728A Withdrawn KR20130041944A (ko) | 2010-07-15 | 2011-07-12 | 베타-아밀로이드 생성의 감소를 위한 화합물 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8637523B2 (https=) |
| EP (1) | EP2593461B1 (https=) |
| JP (1) | JP5755739B2 (https=) |
| KR (1) | KR20130041944A (https=) |
| CN (1) | CN102971325B (https=) |
| AR (1) | AR082241A1 (https=) |
| AU (1) | AU2011279412B2 (https=) |
| BR (1) | BR112013000920A2 (https=) |
| CA (1) | CA2805294A1 (https=) |
| CO (1) | CO6670589A2 (https=) |
| EA (1) | EA021527B1 (https=) |
| IL (1) | IL224202A (https=) |
| MX (1) | MX2013000514A (https=) |
| NZ (1) | NZ606950A (https=) |
| SG (1) | SG186392A1 (https=) |
| TW (1) | TW201206946A (https=) |
| WO (1) | WO2012009309A1 (https=) |
| ZA (1) | ZA201301178B (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0696663B2 (ja) | 1986-08-04 | 1994-11-30 | 東レ株式会社 | 樹脂組成物 |
| US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
| RS58514B1 (sr) | 2012-06-13 | 2019-04-30 | Incyte Holdings Corp | Supstituisana triciklična jedinjenja kao inhibitori fgfr |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| KR101473081B1 (ko) | 2013-01-25 | 2014-12-16 | 영남대학교 산학협력단 | 고리형 2-다이아조-1,3-다이카보닐 화합물을 출발물질로 하는 고리형 베타-엔아미노아마이드 유도체 및 우라실 유도체의 합성방법 |
| PH12015502383B1 (en) | 2013-04-19 | 2023-02-03 | Incyte Holdings Corp | Bicyclic heterocycles as fgfr inhibitors |
| WO2014180524A1 (en) * | 2013-05-06 | 2014-11-13 | Merck Patent Gmbh | Macrocycles as kinase inhibitors |
| DK3004080T3 (da) | 2013-06-04 | 2019-01-02 | Acturum Real Estate Ab | Triazolforbindelser og deres anvendelse som gamma-sekretase-modulatorer |
| US9611254B2 (en) | 2013-06-04 | 2017-04-04 | Acturum Life Science AB | Triazole compounds and their use as gamma secretase modulators |
| NO3004079T3 (https=) | 2013-06-04 | 2018-06-16 | ||
| EP3126355A1 (en) * | 2014-04-02 | 2017-02-08 | Bristol-Myers Squibb Company | Difluoromethoxy compound with low bioactivation potential for the reduction of beta-amyloid production |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| TWI712601B (zh) | 2015-02-20 | 2020-12-11 | 美商英塞特公司 | 作為fgfr抑制劑之雙環雜環 |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| JP6847099B2 (ja) | 2015-09-29 | 2021-03-24 | バイエル ファーマ アクチエンゲゼルシャフト | 新規な大環状スルホンジイミン化合物 |
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| EP3601236A1 (en) | 2017-03-28 | 2020-02-05 | Bayer Aktiengesellschaft | Novel ptefb inhibiting macrocyclic compounds |
| ES2900199T3 (es) | 2017-03-28 | 2022-03-16 | Bayer Ag | Novedosos compuestos macrocíclicos inhibidores de PTEFB |
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| AU2019262579B2 (en) | 2018-05-04 | 2024-09-12 | Incyte Corporation | Salts of an FGFR inhibitor |
| HRP20241288T1 (hr) | 2018-05-04 | 2024-12-06 | Incyte Corporation | Čvrsti oblici fgfr inhibitora i postupci za njihovu proizvodnju |
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| CN113412260B (zh) * | 2019-01-29 | 2022-08-02 | 山东轩竹医药科技有限公司 | 己酮糖激酶抑制剂及其用途 |
| US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| CA3157361A1 (en) | 2019-10-14 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| JP7832891B2 (ja) | 2019-12-04 | 2026-03-18 | インサイト・コーポレイション | Ｆｇｆｒ阻害剤の誘導体 |
| CA3163875A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| WO2022221170A1 (en) | 2021-04-12 | 2022-10-20 | Incyte Corporation | Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent |
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| WO2007058627A1 (en) * | 2005-11-16 | 2007-05-24 | S*Bio Pte Ltd | Oxygen linked pyrimidine derivatives |
| US7932261B2 (en) * | 2006-02-06 | 2011-04-26 | Janssen Pharmaceutica Nv | Macrocycle derivatives useful as inhibitors of β-secretase (BACE) |
| ITMI20061513A1 (it) | 2006-07-31 | 2008-02-01 | Poli Costruzione Materiali Trazione Spa | Unita' frenante compatta a disco per veicoli su rotaia |
| US8450343B2 (en) * | 2007-12-06 | 2013-05-28 | Xianhai Huang | Gamma secretase modulators |
| EP2227471A1 (en) * | 2007-12-11 | 2010-09-15 | Schering Corporation | Gamma secretase modulators |
| WO2009087127A1 (en) * | 2008-01-11 | 2009-07-16 | F. Hoffmann-La Roche Ag | Modulators for amyloid beta |
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| IL224202A (en) | 2016-04-21 |
| SG186392A1 (en) | 2013-02-28 |
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| JP2013531040A (ja) | 2013-08-01 |
| EP2593461A1 (en) | 2013-05-22 |
| EA021527B1 (ru) | 2015-07-30 |
| TW201206946A (en) | 2012-02-16 |
| BR112013000920A2 (pt) | 2016-05-17 |
| EP2593461B1 (en) | 2016-08-17 |
| AR082241A1 (es) | 2012-11-21 |
| ZA201301178B (en) | 2014-07-30 |
| MX2013000514A (es) | 2013-02-27 |
| US8637523B2 (en) | 2014-01-28 |
| CN102971325B (zh) | 2016-01-20 |
| NZ606950A (en) | 2014-08-29 |
| CN102971325A (zh) | 2013-03-13 |
| JP5755739B2 (ja) | 2015-07-29 |
| CO6670589A2 (es) | 2013-05-15 |
| AU2011279412A1 (en) | 2013-03-07 |
| US20120184565A1 (en) | 2012-07-19 |
| CA2805294A1 (en) | 2012-01-19 |
| WO2012009309A1 (en) | 2012-01-19 |
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