CN102971325B - 用于减少β-淀粉样蛋白产生的化合物 - Google Patents
用于减少β-淀粉样蛋白产生的化合物 Download PDFInfo
- Publication number
- CN102971325B CN102971325B CN201180034655.5A CN201180034655A CN102971325B CN 102971325 B CN102971325 B CN 102971325B CN 201180034655 A CN201180034655 A CN 201180034655A CN 102971325 B CN102971325 B CN 102971325B
- Authority
- CN
- China
- Prior art keywords
- bridge
- nitrilo
- cyclopenta
- oxa
- methyne
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CCC1C=CC(*)=C(CBO*F)*1 Chemical compound CCC1C=CC(*)=C(CBO*F)*1 0.000 description 16
- MGRDZFQJWDGFDB-IZZDOVSWSA-N C/C(/NC/C(/OCC=C)=C\C(N)=C)=N/C=N Chemical compound C/C(/NC/C(/OCC=C)=C\C(N)=C)=N/C=N MGRDZFQJWDGFDB-IZZDOVSWSA-N 0.000 description 1
- HTTNIEYLNURGCY-RERGGYADSA-N CC/N=C\N([C@@H]1C(OCC=C)=CC(C=C)=CC1)N Chemical compound CC/N=C\N([C@@H]1C(OCC=C)=CC(C=C)=CC1)N HTTNIEYLNURGCY-RERGGYADSA-N 0.000 description 1
- OCGWDIOQORDDLB-UHFFFAOYSA-N CCC(CCCC/N=N\N)C1C=CC=CC1 Chemical compound CCC(CCCC/N=N\N)C1C=CC=CC1 OCGWDIOQORDDLB-UHFFFAOYSA-N 0.000 description 1
- VQWKHNQHNZDAIC-UHFFFAOYSA-N CCCC(C(CCC1C(CC2)=CC=C2F)=C1N=C)NCl Chemical compound CCCC(C(CCC1C(CC2)=CC=C2F)=C1N=C)NCl VQWKHNQHNZDAIC-UHFFFAOYSA-N 0.000 description 1
- CUIJRCFWQJUKOU-JGPMDLGTSA-N CC[C@@H](C(OCC[C@H](C)CC[IH][C@H](CCC(C)C1C=CC=CC1)N)=C=CNC)[n]1cnc(C)c1 Chemical compound CC[C@@H](C(OCC[C@H](C)CC[IH][C@H](CCC(C)C1C=CC=CC1)N)=C=CNC)[n]1cnc(C)c1 CUIJRCFWQJUKOU-JGPMDLGTSA-N 0.000 description 1
- DYBQGBMLXGFRAI-UHFFFAOYSA-N Cc1ncn[n]1-c(ccc(N=O)c1)c1OCC=C Chemical compound Cc1ncn[n]1-c(ccc(N=O)c1)c1OCC=C DYBQGBMLXGFRAI-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36442510P | 2010-07-15 | 2010-07-15 | |
| US61/364425 | 2010-07-15 | ||
| US61/364,425 | 2010-07-15 | ||
| PCT/US2011/043628 WO2012009309A1 (en) | 2010-07-15 | 2011-07-12 | Compounds for the reduction of beta-amyloid production |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102971325A CN102971325A (zh) | 2013-03-13 |
| CN102971325B true CN102971325B (zh) | 2016-01-20 |
Family
ID=44511486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201180034655.5A Expired - Fee Related CN102971325B (zh) | 2010-07-15 | 2011-07-12 | 用于减少β-淀粉样蛋白产生的化合物 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8637523B2 (https=) |
| EP (1) | EP2593461B1 (https=) |
| JP (1) | JP5755739B2 (https=) |
| KR (1) | KR20130041944A (https=) |
| CN (1) | CN102971325B (https=) |
| AR (1) | AR082241A1 (https=) |
| AU (1) | AU2011279412B2 (https=) |
| BR (1) | BR112013000920A2 (https=) |
| CA (1) | CA2805294A1 (https=) |
| CO (1) | CO6670589A2 (https=) |
| EA (1) | EA021527B1 (https=) |
| IL (1) | IL224202A (https=) |
| MX (1) | MX2013000514A (https=) |
| NZ (1) | NZ606950A (https=) |
| SG (1) | SG186392A1 (https=) |
| TW (1) | TW201206946A (https=) |
| WO (1) | WO2012009309A1 (https=) |
| ZA (1) | ZA201301178B (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0696663B2 (ja) | 1986-08-04 | 1994-11-30 | 東レ株式会社 | 樹脂組成物 |
| US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
| ES2704744T3 (es) | 2012-06-13 | 2019-03-19 | Incyte Holdings Corp | Compuestos tricíclicos sustituidos como inhibidores de FGFR |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| KR101473081B1 (ko) | 2013-01-25 | 2014-12-16 | 영남대학교 산학협력단 | 고리형 2-다이아조-1,3-다이카보닐 화합물을 출발물질로 하는 고리형 베타-엔아미노아마이드 유도체 및 우라실 유도체의 합성방법 |
| EA035095B1 (ru) | 2013-04-19 | 2020-04-27 | Инсайт Холдингс Корпорейшн | Бициклические гетероциклы в качестве ингибиторов fgfr |
| CN105164136B (zh) * | 2013-05-06 | 2017-12-22 | 默克专利股份公司 | 作为激酶抑制剂的大环化合物 |
| JP6368776B2 (ja) | 2013-06-04 | 2018-08-01 | アクチュラム・ライフ・サイエンス・アクチエボラーグ | トリアゾール化合物およびガンマセクレターゼモジュレーターとしてのその使用 |
| WO2014195323A1 (en) | 2013-06-04 | 2014-12-11 | Acturum Life Science AB | Pyrimidine compounds and their use as gamma secretase modulators |
| JP6396438B2 (ja) | 2013-06-04 | 2018-09-26 | アクチュラム・ライフ・サイエンス・アクチエボラーグ | トリアゾール化合物およびガンマセクレターゼモジュレーターとしてのその使用 |
| US9833454B2 (en) | 2014-04-02 | 2017-12-05 | Bristol-Myers Squibb Company | Difluoromethoxy compound with low bioactivation potential for the reduction of beta-amyloid production |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
| MX373169B (es) | 2015-02-20 | 2020-04-24 | Incyte Holdings Corp | Heterociclos bicíclicos como inhibidores de receptores del factor de crecimiento fibroblástico (fgfr). |
| US10717749B2 (en) | 2015-09-29 | 2020-07-21 | Bayer Pharma Aktiengesellschaft | Macrocyclic sulfondiimine compounds |
| JP6888000B2 (ja) | 2015-10-08 | 2021-06-16 | バイエル ファーマ アクチエンゲゼルシャフト | 新規な修飾された大環状化合物 |
| WO2017060322A2 (en) | 2015-10-10 | 2017-04-13 | Bayer Pharma Aktiengesellschaft | Ptefb-inhibitor-adc |
| EP3601253B1 (en) | 2017-03-28 | 2021-09-15 | Bayer Aktiengesellschaft | Novel ptefb inhibiting macrocyclic compounds |
| CA3057891A1 (en) | 2017-03-28 | 2018-10-04 | Bayer Aktiengesellschaft | Novel ptefb inhibiting macrocyclic compounds |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| CR20200590A (es) | 2018-05-04 | 2021-04-26 | Incyte Corp | Formas sólidas de un inhibidor de fgfr y procesos para prepararlas |
| MA52493A (fr) | 2018-05-04 | 2021-03-10 | Incyte Corp | Sels d'un inhibiteur de fgfr |
| CN111471056B (zh) * | 2019-01-23 | 2021-07-02 | 成都先导药物开发股份有限公司 | 一种大环类免疫调节剂 |
| PH12021551635A1 (en) | 2019-01-29 | 2022-05-02 | Shandong Xuanzhu Pharma Co Ltd | Hexone glucokinase inhibitor and use thereof |
| WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
| WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| TWI891666B (zh) | 2019-10-14 | 2025-08-01 | 美商英塞特公司 | 作為ｆｇｆｒ抑制劑之雙環雜環 |
| WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| EP4069696A1 (en) | 2019-12-04 | 2022-10-12 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| BR112022010664A2 (pt) | 2019-12-04 | 2022-08-16 | Incyte Corp | Derivados de um inibidor de fgfr |
| WO2021146424A1 (en) | 2020-01-15 | 2021-07-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| TW202304459A (zh) | 2021-04-12 | 2023-02-01 | 美商英塞特公司 | 包含ｆｇｆｒ抑制劑及ｎｅｃｔｉｎ－４靶向劑之組合療法 |
| EP4352059A1 (en) | 2021-06-09 | 2024-04-17 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| WO2022261159A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009073777A1 (en) * | 2007-12-06 | 2009-06-11 | Schering Corporation | Gamma secretase modulators |
| WO2009076352A1 (en) * | 2007-12-11 | 2009-06-18 | Schering Corporation | Gamma secretase modulators |
| WO2009087127A1 (en) * | 2008-01-11 | 2009-07-16 | F. Hoffmann-La Roche Ag | Modulators for amyloid beta |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ568325A (en) * | 2005-11-16 | 2011-05-27 | S Bio Pte Ltd | Macrocyclic oxygen linked pyrimidine derivatives |
| US7932261B2 (en) * | 2006-02-06 | 2011-04-26 | Janssen Pharmaceutica Nv | Macrocycle derivatives useful as inhibitors of β-secretase (BACE) |
| ITMI20061513A1 (it) | 2006-07-31 | 2008-02-01 | Poli Costruzione Materiali Trazione Spa | Unita' frenante compatta a disco per veicoli su rotaia |
-
2011
- 2011-07-11 TW TW100124501A patent/TW201206946A/zh unknown
- 2011-07-12 CA CA2805294A patent/CA2805294A1/en not_active Abandoned
- 2011-07-12 EP EP11746340.6A patent/EP2593461B1/en not_active Not-in-force
- 2011-07-12 KR KR1020137003728A patent/KR20130041944A/ko not_active Withdrawn
- 2011-07-12 NZ NZ606950A patent/NZ606950A/en not_active IP Right Cessation
- 2011-07-12 AU AU2011279412A patent/AU2011279412B2/en not_active Ceased
- 2011-07-12 SG SG2012093274A patent/SG186392A1/en unknown
- 2011-07-12 WO PCT/US2011/043628 patent/WO2012009309A1/en not_active Ceased
- 2011-07-12 CN CN201180034655.5A patent/CN102971325B/zh not_active Expired - Fee Related
- 2011-07-12 JP JP2013519760A patent/JP5755739B2/ja not_active Expired - Fee Related
- 2011-07-12 BR BR112013000920A patent/BR112013000920A2/pt not_active IP Right Cessation
- 2011-07-12 MX MX2013000514A patent/MX2013000514A/es active IP Right Grant
- 2011-07-12 US US13/180,623 patent/US8637523B2/en active Active
- 2011-07-12 EA EA201270824A patent/EA021527B1/ru not_active IP Right Cessation
- 2011-07-15 AR ARP110102569A patent/AR082241A1/es not_active Application Discontinuation
-
2013
- 2013-01-13 IL IL224202A patent/IL224202A/en not_active IP Right Cessation
- 2013-02-11 CO CO13027683A patent/CO6670589A2/es active IP Right Grant
- 2013-02-14 ZA ZA2013/01178A patent/ZA201301178B/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009073777A1 (en) * | 2007-12-06 | 2009-06-11 | Schering Corporation | Gamma secretase modulators |
| WO2009076352A1 (en) * | 2007-12-11 | 2009-06-18 | Schering Corporation | Gamma secretase modulators |
| WO2009087127A1 (en) * | 2008-01-11 | 2009-07-16 | F. Hoffmann-La Roche Ag | Modulators for amyloid beta |
Non-Patent Citations (1)
| Title |
|---|
| β-Amyloid Peptide as a target for treatment of Alzheimer"s disease;Santiago Conde;《Expert Opin. Ther. Patents》;20020101;第12卷(第4期);第503-512页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| MX2013000514A (es) | 2013-02-27 |
| BR112013000920A2 (pt) | 2016-05-17 |
| JP2013531040A (ja) | 2013-08-01 |
| EP2593461B1 (en) | 2016-08-17 |
| CN102971325A (zh) | 2013-03-13 |
| KR20130041944A (ko) | 2013-04-25 |
| US20120184565A1 (en) | 2012-07-19 |
| NZ606950A (en) | 2014-08-29 |
| IL224202A (en) | 2016-04-21 |
| AU2011279412A1 (en) | 2013-03-07 |
| JP5755739B2 (ja) | 2015-07-29 |
| WO2012009309A1 (en) | 2012-01-19 |
| US8637523B2 (en) | 2014-01-28 |
| TW201206946A (en) | 2012-02-16 |
| SG186392A1 (en) | 2013-02-28 |
| EP2593461A1 (en) | 2013-05-22 |
| ZA201301178B (en) | 2014-07-30 |
| CO6670589A2 (es) | 2013-05-15 |
| EA201270824A1 (ru) | 2013-04-30 |
| EA021527B1 (ru) | 2015-07-30 |
| CA2805294A1 (en) | 2012-01-19 |
| AR082241A1 (es) | 2012-11-21 |
| AU2011279412B2 (en) | 2014-12-11 |
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| PB01 | Publication | ||
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| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160120 Termination date: 20170712 |