KR20130027551A - 부탄올 생산을 위한 효모 생산 배양물 - Google Patents

부탄올 생산을 위한 효모 생산 배양물 Download PDF

Info

Publication number
KR20130027551A
KR20130027551A KR1020137001143A KR20137001143A KR20130027551A KR 20130027551 A KR20130027551 A KR 20130027551A KR 1020137001143 A KR1020137001143 A KR 1020137001143A KR 20137001143 A KR20137001143 A KR 20137001143A KR 20130027551 A KR20130027551 A KR 20130027551A
Authority
KR
South Korea
Prior art keywords
ala
gly
leu
val
ile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020137001143A
Other languages
English (en)
Korean (ko)
Inventor
바산타 나가라잔
마이클 지. 브라무치
Original Assignee
부타맥스 어드밴스드 바이오퓨얼스 엘엘씨
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 filed Critical 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨
Publication of KR20130027551A publication Critical patent/KR20130027551A/ko
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14Fungi; Culture media therefor
    • C12N1/145Fungal isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14Fungi; Culture media therefor
    • C12N1/16Yeasts; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14Fungi; Culture media therefor
    • C12N1/16Yeasts; Culture media therefor
    • C12N1/18Baker's yeast; Brewer's yeast
    • C12N1/185Saccharomyces isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/01Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/02Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/16Butanols
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/645Fungi ; Processes using fungi
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/645Fungi ; Processes using fungi
    • C12R2001/85Saccharomyces
    • C12R2001/865Saccharomyces cerevisiae
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02EREDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00Technologies for the production of fuel of non-fossil origin
    • Y02E50/10Biofuels, e.g. bio-diesel

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020137001143A 2010-06-17 2011-06-16 부탄올 생산을 위한 효모 생산 배양물 Withdrawn KR20130027551A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35573310P 2010-06-17 2010-06-17
US61/355,733 2010-06-17
PCT/US2011/040697 WO2011159894A1 (en) 2010-06-17 2011-06-16 Yeast production culture for the production of butanol

Publications (1)

Publication Number Publication Date
KR20130027551A true KR20130027551A (ko) 2013-03-15

Family

ID=44627329

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020137001143A Withdrawn KR20130027551A (ko) 2010-06-17 2011-06-16 부탄올 생산을 위한 효모 생산 배양물

Country Status (12)

Country Link
US (1) US20120149080A1 (enExample)
EP (1) EP2582786A1 (enExample)
JP (1) JP2013528398A (enExample)
KR (1) KR20130027551A (enExample)
CN (1) CN103201376A (enExample)
AU (1) AU2011268326B2 (enExample)
BR (1) BR112012031847A2 (enExample)
CA (1) CA2801576A1 (enExample)
MX (1) MX2012014550A (enExample)
NZ (1) NZ603546A (enExample)
WO (1) WO2011159894A1 (enExample)
ZA (1) ZA201208575B (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8945899B2 (en) 2007-12-20 2015-02-03 Butamax Advanced Biofuels Llc Ketol-acid reductoisomerase using NADH
JP5582576B2 (ja) 2007-04-18 2014-09-03 ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー 活性の高いケトール酸レダクトイソメラーゼ酵素を用いたイソブタノールの発酵生成
US8188250B2 (en) * 2008-04-28 2012-05-29 Butamax(Tm) Advanced Biofuels Llc Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans
KR20110063576A (ko) 2008-09-29 2011-06-10 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 효모에서 증가된 이종성 Fe-S 효소 활성
CA2784903A1 (en) 2009-12-29 2011-07-28 Butamax(Tm) Advanced Biofuels Llc Alcohol dehydrogenases (adh) useful for fermentive production of lower alkyl alcohols
MX348605B (es) 2010-02-17 2017-06-21 Butamax(Tm) Advanced Biofuels Llc Mejoramiento de la actividad de proteinas que requieren centros fe-s.
NZ722791A (en) 2010-09-07 2018-12-21 Butamax Tm Advanced Biofuels Integration of a polynucleotide encoding a polypeptide that catalyzes pyruvate to acetolactate conversion
ES2716876T3 (es) 2011-03-14 2019-06-17 Easel Biotechnologies Llc Síntesis microbiana de aldehídos y alcoholes correspondientes
KR20140092759A (ko) 2011-03-24 2014-07-24 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 숙주 세포 및 아이소부탄올의 제조 방법
MX2014000966A (es) 2011-07-28 2014-07-09 Butamax Advanced Biofuels Llc Enzimas cetoisovalerato descarboxilasa y metodos de uso de las mismas.
CA2854450C (en) 2011-11-03 2020-04-21 Easel Biotechnologies, Llc Microbial production of n-butyraldehyde
WO2013086222A2 (en) 2011-12-09 2013-06-13 Butamax(Tm) Advanced Biofuels Llc Process to remove product alcohols from fermentation broth
CA2861613A1 (en) 2011-12-30 2013-07-04 Butamax Advanced Biofuels Llc Fermentative production of alcohols
JP2015503351A (ja) 2011-12-30 2015-02-02 ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー ブタノール生産のための遺伝的スイッチ
KR20140146616A (ko) 2012-03-23 2014-12-26 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 부타놀로겐용 배지의 아세테이트 보충물
NZ701099A (en) 2012-05-11 2017-04-28 Butamax Advanced Biofuels Llc Ketol-acid reductoisomerase enzymes and methods of use
BR112015003701A2 (pt) 2012-08-22 2017-12-12 Butamax Advanced Biofuels Llc células hospedeiras recombinantes, método para aprimoramento, processo para a produção de um álcool, polinucleotídeo isolado, cassete de expressão e composição
US9840724B2 (en) 2012-09-21 2017-12-12 Butamax Advanced Biofuels Llc Production of renewable hydrocarbon compositions
CN105102616A (zh) 2012-09-26 2015-11-25 布特马斯先进生物燃料有限责任公司 具有酮醇酸还原异构酶活性的多肽
US9273330B2 (en) 2012-10-03 2016-03-01 Butamax Advanced Biofuels Llc Butanol tolerance in microorganisms
US9650624B2 (en) 2012-12-28 2017-05-16 Butamax Advanced Biofuels Llc DHAD variants for butanol production
US9441250B2 (en) 2013-03-14 2016-09-13 Butamax Advanced Biofuels Llc Glycerol 3- phosphate dehydrogenase for butanol production
US9034631B2 (en) * 2013-03-14 2015-05-19 Poet Research, Inc. Systems and methods for yeast propagation
US9771602B2 (en) 2013-03-15 2017-09-26 Butamax Advanced Biofuels Llc Competitive growth and/or production advantage for butanologen microorganism
US9580705B2 (en) 2013-03-15 2017-02-28 Butamax Advanced Biofuels Llc DHAD variants and methods of screening
US9663759B2 (en) * 2013-07-03 2017-05-30 Butamax Advanced Biofuels Llc Partial adaptation for butanol production
US10280438B2 (en) 2014-08-11 2019-05-07 Butamax Advanced Biofuels Llc Method for the production of yeast
BR112017017120A2 (pt) * 2015-02-10 2018-04-03 Erbslöh Geisenheim AG método de produção de leveduras mutantes e seu uso
EP3452606A4 (en) 2016-05-05 2020-01-01 Newpek S.A. De C.V. ENZYMATIC PROCESSES FOR THE PRODUCTION OF BUTANOL

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4284724A (en) 1977-08-25 1981-08-18 Hideki Fukuda Method of highly concentrated cultivation of yeasts
US4414329A (en) 1980-01-15 1983-11-08 Phillips Petroleum Company Biochemical conversions by yeast fermentation at high cell densities
US4765992A (en) 1984-06-01 1988-08-23 Universite De Bordeaux Ii Stimulation of alcoholic fermentation by adsorption of toxic substances with cell walls
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US9297028B2 (en) 2005-09-29 2016-03-29 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
US8945899B2 (en) 2007-12-20 2015-02-03 Butamax Advanced Biofuels Llc Ketol-acid reductoisomerase using NADH
US8956850B2 (en) 2008-06-05 2015-02-17 Butamax Advanced Biofuels Llc Enhanced pyruvate to acetolactate conversion in yeast
UA96928C2 (ru) 2005-10-26 2011-12-26 Э.И. Дю Пон Де Немур Энд Компани Ферментативное продуцирование спиртов с четырьмя атомами углерода
US8206970B2 (en) 2006-05-02 2012-06-26 Butamax(Tm) Advanced Biofuels Llc Production of 2-butanol and 2-butanone employing aminobutanol phosphate phospholyase
US8828704B2 (en) 2006-05-02 2014-09-09 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
JP5582576B2 (ja) 2007-04-18 2014-09-03 ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー 活性の高いケトール酸レダクトイソメラーゼ酵素を用いたイソブタノールの発酵生成
MX2010003501A (es) 2007-10-04 2010-06-09 Bio Architecture Lab Inc Produccion de biocombustible.
BRPI0818888A2 (pt) * 2007-10-26 2014-11-04 Arbor Fuel Inc Métodos para a produção de n-butanol.
ES2575413T3 (es) 2007-12-20 2016-06-28 Butamax (Tm) Advanced Biofuels Llc Cetol-ácido reductoisomerasa que utiliza NADH
AU2008345126A1 (en) 2007-12-27 2009-07-09 Gevo, Inc. Recovery of higher alcohols from dilute aqueous solutions
US8188250B2 (en) 2008-04-28 2012-05-29 Butamax(Tm) Advanced Biofuels Llc Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans
MX2010013182A (es) * 2008-06-04 2011-01-14 Butamax Tm Advanced Biofuels Metodo para producir butanol mediante el uso de fermentacion extractiva de dos fases.
WO2010037112A1 (en) 2008-09-29 2010-04-01 Butamax™ Advanced Biofuels LLC IDENTIFICATION AND USE OF BACTERIAL [2Fe-2S] DIHYDROXY-ACID DEHYDRATASES
BRPI0914521A2 (pt) 2008-10-27 2016-07-26 Butamax Advanced Biofuels Llc célula hospedeira microbiana recombinante, método de aumento da produção de isobutanol e método de produção de isobutanol
US20110124068A1 (en) 2009-06-26 2011-05-26 Evanko William A Recovery of higher alcohols from dilute aqueous solutions
IN2012DN02227A (enExample) 2009-09-29 2015-08-21 Butamax Tm Advanced Biofuels
WO2011041426A1 (en) 2009-09-29 2011-04-07 Butamax(Tm) Advanced Biofuels Llc Improved yeast production host cells

Also Published As

Publication number Publication date
MX2012014550A (es) 2013-01-29
CN103201376A (zh) 2013-07-10
NZ603546A (en) 2014-10-31
AU2011268326A1 (en) 2012-12-06
JP2013528398A (ja) 2013-07-11
WO2011159894A1 (en) 2011-12-22
BR112012031847A2 (pt) 2016-02-16
ZA201208575B (en) 2014-01-29
EP2582786A1 (en) 2013-04-24
CA2801576A1 (en) 2011-12-22
US20120149080A1 (en) 2012-06-14
AU2011268326B2 (en) 2015-02-05

Similar Documents

Publication Publication Date Title
KR20130027551A (ko) 부탄올 생산을 위한 효모 생산 배양물
US9909148B2 (en) Fermentative production of alcohols
US9909149B2 (en) DHAD variants for butanol production
EP2970863B1 (en) Glycerol 3- phosphate dehydrogenase for butanol production
EP3269806B1 (en) Integration of a polynucleotide encoding a polypeptide that catalyzes pyruvate to acetolactate conversion
US9388392B2 (en) Ketol-acid reductoisomerase enzymes and methods of use
US8669094B2 (en) Enhanced pyruvate to acetolactate conversion in yeast
US20140186911A1 (en) Recombinant host cells and methods for producing butanol
US20140096439A1 (en) Butanol tolerance in microorganisms
KR20110011675A (ko) 4 탄소 알코올의 생산을 위해 개선된 효모 균주
CN105102616A (zh) 具有酮醇酸还原异构酶活性的多肽
WO2014151190A1 (en) Dhad variants and methods of screening
US20150218595A1 (en) Fermentative production of alcohols
US20160138050A1 (en) Yeast with increased butanol tolerance involving cell wall proteins
US20160326551A1 (en) Isobutanol tolerance in yeast with an altered lipid profile
WO2014105840A1 (en) Fermentative production of alcohols

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20130116

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid