CN103201376A - 用于生产丁醇的酵母生产培养物 - Google Patents

用于生产丁醇的酵母生产培养物 Download PDF

Info

Publication number
CN103201376A
CN103201376A CN2011800298462A CN201180029846A CN103201376A CN 103201376 A CN103201376 A CN 103201376A CN 2011800298462 A CN2011800298462 A CN 2011800298462A CN 201180029846 A CN201180029846 A CN 201180029846A CN 103201376 A CN103201376 A CN 103201376A
Authority
CN
China
Prior art keywords
yeast
culture
production
butanols
butanol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2011800298462A
Other languages
English (en)
Chinese (zh)
Inventor
V.纳加拉彦
M.G.布拉穆奇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Butamax Advanced Biofuels LLC
Original Assignee
Butamax Advanced Biofuels LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Butamax Advanced Biofuels LLC filed Critical Butamax Advanced Biofuels LLC
Publication of CN103201376A publication Critical patent/CN103201376A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14Fungi; Culture media therefor
    • C12N1/16Yeasts; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14Fungi; Culture media therefor
    • C12N1/145Fungal isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14Fungi; Culture media therefor
    • C12N1/16Yeasts; Culture media therefor
    • C12N1/18Baker's yeast; Brewer's yeast
    • C12N1/185Saccharomyces isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/01Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/02Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/16Butanols
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/645Fungi ; Processes using fungi
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/645Fungi ; Processes using fungi
    • C12R2001/85Saccharomyces
    • C12R2001/865Saccharomyces cerevisiae
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02EREDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00Technologies for the production of fuel of non-fossil origin
    • Y02E50/10Biofuels, e.g. bio-diesel

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Botany (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN2011800298462A 2010-06-17 2011-06-16 用于生产丁醇的酵母生产培养物 Pending CN103201376A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35573310P 2010-06-17 2010-06-17
US61/355,733 2010-06-17
PCT/US2011/040697 WO2011159894A1 (en) 2010-06-17 2011-06-16 Yeast production culture for the production of butanol

Publications (1)

Publication Number Publication Date
CN103201376A true CN103201376A (zh) 2013-07-10

Family

ID=44627329

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2011800298462A Pending CN103201376A (zh) 2010-06-17 2011-06-16 用于生产丁醇的酵母生产培养物

Country Status (12)

Country Link
US (1) US20120149080A1 (enExample)
EP (1) EP2582786A1 (enExample)
JP (1) JP2013528398A (enExample)
KR (1) KR20130027551A (enExample)
CN (1) CN103201376A (enExample)
AU (1) AU2011268326B2 (enExample)
BR (1) BR112012031847A2 (enExample)
CA (1) CA2801576A1 (enExample)
MX (1) MX2012014550A (enExample)
NZ (1) NZ603546A (enExample)
WO (1) WO2011159894A1 (enExample)
ZA (1) ZA201208575B (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8945899B2 (en) 2007-12-20 2015-02-03 Butamax Advanced Biofuels Llc Ketol-acid reductoisomerase using NADH
KR101573775B1 (ko) 2007-04-18 2015-12-04 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 고도 활성 케톨-산 리덕토아이소머라아제 효소를 이용한 아이소부탄올의 발효 생산
US8188250B2 (en) * 2008-04-28 2012-05-29 Butamax(Tm) Advanced Biofuels Llc Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans
KR20110063576A (ko) 2008-09-29 2011-06-10 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 효모에서 증가된 이종성 Fe-S 효소 활성
CN102762722B (zh) 2009-12-29 2015-05-20 布特马斯先进生物燃料有限责任公司 用于发酵生产低级烷基醇的醇脱氢酶(adh)
US9297016B2 (en) 2010-02-17 2016-03-29 Butamax Advanced Biofuels Llc Activity of Fe—S cluster requiring proteins
EP3269806B1 (en) 2010-09-07 2020-05-27 Butamax (TM) Advanced Biofuels LLC Integration of a polynucleotide encoding a polypeptide that catalyzes pyruvate to acetolactate conversion
CA2830215C (en) 2011-03-14 2018-07-10 Easel Biotechnologies, Llc Microbial synthesis of aldehydes and corresponding alcohols
CA2831130C (en) 2011-03-24 2021-10-26 Butamax (Tm) Advanced Biofuels Llc Host cells and methods for production of isobutanol
JP6093764B2 (ja) 2011-07-28 2017-03-08 ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー ケトイソ吉草酸デカルボキシラーゼ酵素およびその使用方法
KR20170096226A (ko) 2011-11-03 2017-08-23 이젤 바이오테크날러지스, 엘엘씨 미생물에 의한 n-부티르알데하이드의 생성
WO2013086222A2 (en) 2011-12-09 2013-06-13 Butamax(Tm) Advanced Biofuels Llc Process to remove product alcohols from fermentation broth
AU2012362144A1 (en) 2011-12-30 2014-07-03 Butamax (Tm) Advanced Biofuels Llc Genetic switches for butanol production
CA2861613A1 (en) 2011-12-30 2013-07-04 Butamax Advanced Biofuels Llc Fermentative production of alcohols
CN104284981A (zh) 2012-03-23 2015-01-14 布特马斯先进生物燃料有限责任公司 在针对产丁醇生物的培养基中补充乙酸盐
WO2013176909A2 (en) 2012-05-11 2013-11-28 Butamax Advanced Biofuels Llc Ketol-acid reductoisomerase enzymes and methods of use
BR112015003701A2 (pt) 2012-08-22 2017-12-12 Butamax Advanced Biofuels Llc células hospedeiras recombinantes, método para aprimoramento, processo para a produção de um álcool, polinucleotídeo isolado, cassete de expressão e composição
US9840724B2 (en) 2012-09-21 2017-12-12 Butamax Advanced Biofuels Llc Production of renewable hydrocarbon compositions
US9512408B2 (en) 2012-09-26 2016-12-06 Butamax Advanced Biofuels Llc Polypeptides with ketol-acid reductoisomerase activity
US9273330B2 (en) 2012-10-03 2016-03-01 Butamax Advanced Biofuels Llc Butanol tolerance in microorganisms
WO2014106107A2 (en) 2012-12-28 2014-07-03 Butamax (Tm) Advanced Biofuels Llc Dhad variants for butanol production
WO2014160050A1 (en) 2013-03-14 2014-10-02 Butamax Advanced Biofuels Llc Glycerol 3- phosphate dehydrogenase for butanol production
US9034631B2 (en) * 2013-03-14 2015-05-19 Poet Research, Inc. Systems and methods for yeast propagation
WO2014151190A1 (en) 2013-03-15 2014-09-25 Butamax Advanced Biofuels Llc Dhad variants and methods of screening
US9771602B2 (en) 2013-03-15 2017-09-26 Butamax Advanced Biofuels Llc Competitive growth and/or production advantage for butanologen microorganism
WO2015002913A1 (en) * 2013-07-03 2015-01-08 Butamax Advanced Biofuels Llc Partial adaptation for butanol production
CA2957920A1 (en) 2014-08-11 2016-02-18 Butamax Advanced Biofuels Llc Yeast preparations and methods of making the same
US20180016543A1 (en) * 2015-02-10 2018-01-18 Erbslöh Geisenheim AG Method of producing yeast mutants and the use thereof
CA3021033A1 (en) 2016-05-05 2017-11-09 Newpek S.A. De C.V. Enzymatic methods for butanol production

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009055072A1 (en) * 2007-10-26 2009-04-30 Arbor Fuel Inc. Methods for the production of n-butanol
WO2009149270A2 (en) * 2008-06-04 2009-12-10 E. I. Du Pont De Nemours And Company A method for producing butanol using two-phase extractive fermentation

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4284724A (en) 1977-08-25 1981-08-18 Hideki Fukuda Method of highly concentrated cultivation of yeasts
US4414329A (en) 1980-01-15 1983-11-08 Phillips Petroleum Company Biochemical conversions by yeast fermentation at high cell densities
US4765992A (en) 1984-06-01 1988-08-23 Universite De Bordeaux Ii Stimulation of alcoholic fermentation by adsorption of toxic substances with cell walls
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US9297028B2 (en) 2005-09-29 2016-03-29 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
NZ566406A (en) 2005-10-26 2012-04-27 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
US8945899B2 (en) 2007-12-20 2015-02-03 Butamax Advanced Biofuels Llc Ketol-acid reductoisomerase using NADH
US8828704B2 (en) 2006-05-02 2014-09-09 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
US8206970B2 (en) 2006-05-02 2012-06-26 Butamax(Tm) Advanced Biofuels Llc Production of 2-butanol and 2-butanone employing aminobutanol phosphate phospholyase
KR101573775B1 (ko) 2007-04-18 2015-12-04 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 고도 활성 케톨-산 리덕토아이소머라아제 효소를 이용한 아이소부탄올의 발효 생산
US20090139134A1 (en) 2007-10-04 2009-06-04 Bio Architecture Lab, Inc. Biofuel production
EP2677028B1 (en) 2007-12-20 2016-03-09 Butamax (TM) Advanced Biofuels LLC Ketol-acid reductoisomerase using NADH
JP2011514140A (ja) 2007-12-27 2011-05-06 ジーヴォ,インコーポレイテッド 低濃度水溶液からの高級アルコールの回収
US8188250B2 (en) 2008-04-28 2012-05-29 Butamax(Tm) Advanced Biofuels Llc Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans
BRPI0909989A2 (pt) 2008-06-05 2021-06-22 Butamax Advanced Biofuels Llc célula de levedura recombinante e método para a produção de um produto
MX2011003238A (es) 2008-09-29 2011-04-28 Butamax Tm Advanced Biofuels Identificacion y uso de dihidroxiacido deshidratasas [2fe-2s] bacterianas.
BRPI0914521A2 (pt) 2008-10-27 2016-07-26 Butamax Advanced Biofuels Llc célula hospedeira microbiana recombinante, método de aumento da produção de isobutanol e método de produção de isobutanol
KR20120104509A (ko) 2009-06-26 2012-09-21 게보 인코포레이티드 묽은 수용액으로부터 고급 알코올들의 회수
WO2011041426A1 (en) 2009-09-29 2011-04-07 Butamax(Tm) Advanced Biofuels Llc Improved yeast production host cells
US20110244536A1 (en) 2009-09-29 2011-10-06 Butamax(Tm) Advanced Biofuels Llc Fermentive production of isobutanol using highly effective ketol-acid reductoisomerase enzymes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009055072A1 (en) * 2007-10-26 2009-04-30 Arbor Fuel Inc. Methods for the production of n-butanol
WO2009149270A2 (en) * 2008-06-04 2009-12-10 E. I. Du Pont De Nemours And Company A method for producing butanol using two-phase extractive fermentation

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
B. SONNLEITNER ET AL: "Dynamics of Glucose Consumption in Yeast", 《BIOTECHNOLOGY PROGRESS》 *
ERIC P. KNOSHAUG ET AL: "Butanol Tolerance in a Selection of Microorganisms", 《APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY》 *
H. VAN URK ET AL: "Glucose Transport in Crabtree-positive and Crabtree-negative Yeasts", 《MICROBIOLOGY》 *
STEEN ERIC J ET AL: "Metabolic engineering of Saccharomyces cerevisiae for the production of n-butanol", 《MICROBIAL CELL FACTORIES》 *

Also Published As

Publication number Publication date
WO2011159894A1 (en) 2011-12-22
EP2582786A1 (en) 2013-04-24
CA2801576A1 (en) 2011-12-22
KR20130027551A (ko) 2013-03-15
AU2011268326A1 (en) 2012-12-06
AU2011268326B2 (en) 2015-02-05
US20120149080A1 (en) 2012-06-14
JP2013528398A (ja) 2013-07-11
BR112012031847A2 (pt) 2016-02-16
NZ603546A (en) 2014-10-31
MX2012014550A (es) 2013-01-29
ZA201208575B (en) 2014-01-29

Similar Documents

Publication Publication Date Title
AU2011268326B2 (en) Yeast production culture for the production of butanol
US10184139B2 (en) Integration of a polynucleotide encoding a polypeptide that catalyzes pyruvate to acetolactate conversion
US8969065B2 (en) Enhanced pyruvate to acetolactate conversion in yeast
EP2401360B1 (en) Yeast with increased butanol tolerance involving a multidrug efflux pump gene
US8557562B2 (en) Yeast with increased butanol tolerance involving filamentous growth response
AU2012362274A1 (en) Fermentative production of alcohols
WO2014144210A2 (en) Competitive growth and/or production advantage for butanologen microorganism
WO2015103002A1 (en) Isobutanol tolerance in yeast with an altered lipid profile

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
AD01 Patent right deemed abandoned

Effective date of abandoning: 20160601

C20 Patent right or utility model deemed to be abandoned or is abandoned