KR20120107493A - 대사성 질환의 치료를 위한 ｐｐａｒ 절약형 티아졸리딘디온염 - Google Patents

대사성 질환의 치료를 위한 ｐｐａｒ 절약형 티아졸리딘디온염 Download PDF

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KR20120107493A
KR20120107493A KR1020127018388A KR20127018388A KR20120107493A KR 20120107493 A KR20120107493 A KR 20120107493A KR 1020127018388 A KR1020127018388 A KR 1020127018388A KR 20127018388 A KR20127018388 A KR 20127018388A KR 20120107493 A KR20120107493 A KR 20120107493A
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South Korea
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salt
ring
compound
formula
alkyl
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English (en)
Korean (ko)
Inventor
제라드 알 콜카
스티븐 피 타니스
스코트 디 라르센
Original Assignee
메타볼릭 솔루션스 디벨롭먼트 컴퍼니, 엘엘씨
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Publication of KR20120107493A publication Critical patent/KR20120107493A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
KR1020127018388A 2009-12-15 2010-12-15 대사성 질환의 치료를 위한 ｐｐａｒ 절약형 티아졸리딘디온염 Ceased KR20120107493A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28676509P 2009-12-15 2009-12-15
US61/286,765 2009-12-15

Related Child Applications (1)

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KR1020177010102A Division KR102029560B1 (ko) 2009-12-15 2010-12-15 대사성 질환의 치료를 위한 ｐｐａｒ 절약형 티아졸리딘디온염

Publications (1)

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KR20120107493A true KR20120107493A (ko) 2012-10-02

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KR1020127018388A Ceased KR20120107493A (ko) 2009-12-15 2010-12-15 대사성 질환의 치료를 위한 ｐｐａｒ 절약형 티아졸리딘디온염
KR1020177010102A Active KR102029560B1 (ko) 2009-12-15 2010-12-15 대사성 질환의 치료를 위한 ｐｐａｒ 절약형 티아졸리딘디온염
KR1020187022229A Active KR102029611B1 (ko) 2009-12-15 2010-12-15 대사성 질환의 치료를 위한 ｐｐａｒ 절약형 티아졸리딘디온염

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KR1020187022229A Active KR102029611B1 (ko) 2009-12-15 2010-12-15 대사성 질환의 치료를 위한 ｐｐａｒ 절약형 티아졸리딘디온염

Country Status (16)

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US (2) US8912335B2 (enExample)
EP (1) EP2513070B1 (enExample)
JP (1) JP5634526B2 (enExample)
KR (3) KR20120107493A (enExample)
CN (1) CN102753539B (enExample)
AU (1) AU2010340055B2 (enExample)
CA (1) CA2783468C (enExample)
DK (1) DK2513070T3 (enExample)
ES (1) ES2658168T3 (enExample)
HU (1) HUE038042T2 (enExample)
MX (1) MX2012006725A (enExample)
NO (1) NO2513070T3 (enExample)
NZ (1) NZ600390A (enExample)
PL (1) PL2513070T3 (enExample)
RU (1) RU2564661C2 (enExample)
WO (1) WO2011084453A1 (enExample)

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EP3080154B1 (en) 2013-12-13 2018-02-07 Sanofi Dual glp-1/gip receptor agonists
EP3080150B1 (en) 2013-12-13 2018-08-01 Sanofi Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
TW201625668A (zh) 2014-04-07 2016-07-16 賽諾菲公司 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物
TW201625669A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑
TW201625670A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
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TW201706291A (zh) 2015-07-10 2017-02-16 賽諾菲公司 作為選擇性肽雙重ｇｌｐ－１／升糖素受體促效劑之新毒蜥外泌肽（ｅｘｅｎｄｉｎ－４）衍生物
WO2019154958A1 (en) 2018-02-08 2019-08-15 Enyo Pharma Use of modulators of neet proteins for the treatment of infection
CN111689934B (zh) * 2020-06-24 2022-08-02 郑州大学 14-脱羟-13-脱氢穿心莲内酯-12-磺酸钾的单晶体及制备方法
GB202210503D0 (en) 2022-07-18 2022-08-31 Univ Court Univ Of Glasgow Materials and methods for treatment of chronic myeloid leukemia (CML)

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Also Published As

Publication number Publication date
PL2513070T3 (pl) 2018-05-30
US9126959B2 (en) 2015-09-08
ES2658168T3 (es) 2018-03-08
KR102029560B1 (ko) 2019-10-07
AU2010340055B2 (en) 2014-07-24
JP2013514367A (ja) 2013-04-25
RU2564661C2 (ru) 2015-10-10
HUE038042T2 (hu) 2018-09-28
US20150051406A1 (en) 2015-02-19
CN102753539B (zh) 2015-09-09
CA2783468A1 (en) 2011-07-14
US20120309975A1 (en) 2012-12-06
KR102029611B1 (ko) 2019-10-07
CA2783468C (en) 2018-10-09
HK1174330A1 (en) 2013-06-07
DK2513070T3 (en) 2018-01-22
NZ600390A (en) 2013-08-30
WO2011084453A1 (en) 2011-07-14
CN102753539A (zh) 2012-10-24
EP2513070A1 (en) 2012-10-24
EP2513070B1 (en) 2017-11-08
US8912335B2 (en) 2014-12-16
NO2513070T3 (enExample) 2018-04-07
JP5634526B2 (ja) 2014-12-03
KR20170044214A (ko) 2017-04-24
KR20180089569A (ko) 2018-08-08
RU2012129930A (ru) 2014-01-27
AU2010340055A1 (en) 2012-06-28
MX2012006725A (es) 2012-06-28

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Patent event date: 20161004

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Patent event date: 20160906

Comment text: Amendment to Specification, etc.

Patent event code: PX09012R01I

Patent event date: 20150826

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Patent event code: PX09012R01I

Patent event date: 20130305

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Patent event code: PX06014S01D

Patent event date: 20170112

Comment text: Amendment to Specification, etc.

Patent event code: PX06012R01I

Patent event date: 20170102

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Patent event code: PX06011S01I

Patent event date: 20161004

Comment text: Amendment to Specification, etc.

Patent event code: PX06012R01I

Patent event date: 20160906

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Patent event date: 20160706

Comment text: Amendment to Specification, etc.

Patent event code: PX06012R01I

Patent event date: 20150826

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Patent event code: PX06012R01I

Patent event date: 20130305

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Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20170413