KR20120088537A - 모르피난 및 모르피논 화합물의 제조방법 - Google Patents

모르피난 및 모르피논 화합물의 제조방법 Download PDF

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KR20120088537A
KR20120088537A KR1020117025806A KR20117025806A KR20120088537A KR 20120088537 A KR20120088537 A KR 20120088537A KR 1020117025806 A KR1020117025806 A KR 1020117025806A KR 20117025806 A KR20117025806 A KR 20117025806A KR 20120088537 A KR20120088537 A KR 20120088537A
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South Korea
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formula
compound
alkylene
alkyl
aryl
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Korean (ko)
Inventor
토마스 허드리키
로버트 캐롤
한스 라이쉬
알레스 마차라
루카스 베르너
데이비드 알. 아담스
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브럭 유니버시티
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Publication of KR20120088537A publication Critical patent/KR20120088537A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C07D489/04—Salts; Organic complexes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
KR1020117025806A 2009-04-24 2010-04-22 모르피난 및 모르피논 화합물의 제조방법 Withdrawn KR20120088537A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17252109P 2009-04-24 2009-04-24
US61/172,521 2009-04-24
PCT/CA2010/000587 WO2010121369A1 (en) 2009-04-24 2010-04-22 Processes for the preparation of morphinane and morphinone compounds

Publications (1)

Publication Number Publication Date
KR20120088537A true KR20120088537A (ko) 2012-08-08

Family

ID=43010633

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020117025806A Withdrawn KR20120088537A (ko) 2009-04-24 2010-04-22 모르피난 및 모르피논 화합물의 제조방법

Country Status (11)

Country Link
US (1) US8853401B2 (https=)
EP (1) EP2421868A4 (https=)
JP (1) JP5824448B2 (https=)
KR (1) KR20120088537A (https=)
CN (1) CN102459275A (https=)
AU (1) AU2010239059B2 (https=)
CA (1) CA2758231A1 (https=)
IL (1) IL215553A (https=)
MX (1) MX2011011245A (https=)
NZ (1) NZ595591A (https=)
WO (1) WO2010121369A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
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WO2010017573A1 (en) * 2008-08-11 2010-02-18 Tasmanian Alkaloids Pty Limited PROCESS FOR MAKING MORPHINAN-6α-OLS
CN102558188B (zh) * 2010-12-17 2014-07-23 北大方正集团有限公司 一种溴甲纳曲酮的制备方法
CN102558189B (zh) * 2010-12-17 2014-09-03 北大方正集团有限公司 溴甲纳曲酮的精制方法
CA2833283A1 (en) * 2011-05-02 2012-11-08 Brock University Processes and intermediates in the preparation of morphine analogs via n-demethylation of n-oxides using cyclodehydration reagents
AU2012253188B2 (en) * 2011-05-06 2016-12-22 Brock University Process for the preparation of morphine analogs via metal catalyzed N-demethylation/functionalization and intramolecular group transfer
US8981098B2 (en) 2012-02-03 2015-03-17 Brock University Process for the preparation of morphine analogs via the reaction of organometallic reagents with an oxazolidine derived from morphinans
US9701688B2 (en) 2014-05-05 2017-07-11 Noramco, Inc. Process for the preparation of opioid compounds
US9701687B2 (en) 2014-05-05 2017-07-11 Noramco, Inc. Process for the preparation of opioid compounds
EP3023427A1 (en) * 2014-11-19 2016-05-25 Siegfried AG Improved method of manufacturing buprenorphine and analogues thereof from oripavine
CN105777765A (zh) * 2014-12-15 2016-07-20 北大方正集团有限公司 一种乙酰化溴甲纳曲酮及其制备方法
CN105777767A (zh) * 2014-12-15 2016-07-20 北大方正集团有限公司 一种乙酰化Delta-7溴甲纳曲酮及其制备方法
WO2018211331A1 (en) * 2017-05-19 2018-11-22 Evolva Sa Preparation of buprenorphine
CN111777617B (zh) * 2020-07-10 2025-06-06 华润三九医药股份有限公司 一种溴甲纳曲酮的精制方法
WO2022127321A1 (zh) * 2020-12-18 2022-06-23 四川大学 一种新型中间体及其制备方法和应用
CN114502560B (zh) * 2020-12-18 2023-06-30 四川大学 一种中间体及其制备方法和应用

Family Cites Families (22)

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GB1136214A (en) 1965-06-15 1968-12-11 Reckitt & Sons Ltd Thebaine and oripavine derivatives
US3474101A (en) 1960-09-05 1969-10-21 Reckitt & Sons Ltd Thebaine and oripavine derivatives
US4176186A (en) 1978-07-28 1979-11-27 Boehringer Ingelheim Gmbh Quaternary derivatives of noroxymorphone which relieve intestinal immobility
ES2127532T3 (es) 1994-05-31 1999-04-16 Mallinckrodt Chemical Inc Preparacion de nalbufina con niveles bajos del epimero beta.
KR100204659B1 (ko) 1996-05-28 1999-06-15 강재헌 신규한 부프레노핀계 진통제용 화합물
AU6934400A (en) * 1999-08-25 2001-03-19 Barrett R. Cooper Compositions and methods for treating opiate intolerance
US7119100B2 (en) 2001-09-14 2006-10-10 Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences, P.L.A. China Oripavine derivatives and their uses as pharmaceuticals
DE10229842A1 (de) 2002-07-03 2004-02-05 Helmut Prof. Dr. Schmidhammer Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung
ATE444295T1 (de) 2002-11-08 2009-10-15 Mallinckrodt Inc Verfahren zur herstellung von quaternäre n-alkyl morphinan alkaloid salzen
AR057035A1 (es) * 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
ES2329296T3 (es) 2006-01-05 2009-11-24 Mallinckrodt, Inc. El uso de oripavina como material de partida para buprenorfina.
KR101421747B1 (ko) 2006-04-21 2014-07-30 넥타르 테라퓨틱스 모르피논의 입체선택적 환원
FR2906252B1 (fr) 2006-09-21 2008-11-28 Sanofi Aventis Sa Procede de preparation d'halogenures de n-aklyl naltrexone
US20080125592A1 (en) 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
JP2010511726A (ja) * 2006-12-04 2010-04-15 ノランコ・インコーポレーテツド １４−ヒドロキシコデイノンの濃度が低いオキシコドンの製造方法
KR100791555B1 (ko) 2007-02-02 2008-01-03 주식회사 선진화학 초미립자 무기금속산화물 수분산체 및 이의 제조방법
EP2132443B1 (de) 2007-03-06 2011-05-18 ixetic Bad Homburg GmbH Pumpe mit einem magnetisch angesteuerten schaltventil zur saugdrosselung
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WO2008138383A1 (de) 2007-05-16 2008-11-20 Cilag Ag Verfahren zur herstellung von n-methylnaltrexonbromid
US7999104B2 (en) * 2007-06-29 2011-08-16 Brock University Methods for one-pot N-demethylation/N-acylation of morphine and tropane alkaloids
GB2450691A (en) 2007-07-02 2009-01-07 Alpharma Aps One-pot preparation of oxycodone from thebaine
CN101570539B (zh) * 2009-06-01 2012-01-11 漆又毛 一种吗啡酮季铵盐衍生物及其制备方法

Also Published As

Publication number Publication date
IL215553A0 (en) 2011-12-29
CA2758231A1 (en) 2010-10-28
NZ595591A (en) 2013-11-29
MX2011011245A (es) 2012-04-11
JP2012524726A (ja) 2012-10-18
AU2010239059B2 (en) 2016-06-09
US8853401B2 (en) 2014-10-07
EP2421868A4 (en) 2012-08-01
WO2010121369A1 (en) 2010-10-28
US20120046465A1 (en) 2012-02-23
EP2421868A1 (en) 2012-02-29
AU2010239059A1 (en) 2011-10-27
IL215553A (en) 2015-01-29
CN102459275A (zh) 2012-05-16
JP5824448B2 (ja) 2015-11-25

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Date Code Title Description
PA0105 International application

Patent event date: 20111028

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid