CN102459275A - 制备吗啡烷和吗啡酮化合物的方法 - Google Patents

制备吗啡烷和吗啡酮化合物的方法 Download PDF

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Publication number
CN102459275A
CN102459275A CN2010800284272A CN201080028427A CN102459275A CN 102459275 A CN102459275 A CN 102459275A CN 2010800284272 A CN2010800284272 A CN 2010800284272A CN 201080028427 A CN201080028427 A CN 201080028427A CN 102459275 A CN102459275 A CN 102459275A
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China
Prior art keywords
compound
formula
alkylene
alkyl
conditions
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Pending
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CN2010800284272A
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English (en)
Chinese (zh)
Inventor
T·胡德利茨基
R·卡罗尔
H·莱施
A·马查拉
L·维尔纳
D·R·亚当斯
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Brock University
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Brock University
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Publication of CN102459275A publication Critical patent/CN102459275A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C07D489/04—Salts; Organic complexes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
CN2010800284272A 2009-04-24 2010-04-22 制备吗啡烷和吗啡酮化合物的方法 Pending CN102459275A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17252109P 2009-04-24 2009-04-24
US61/172,521 2009-04-24
PCT/CA2010/000587 WO2010121369A1 (en) 2009-04-24 2010-04-22 Processes for the preparation of morphinane and morphinone compounds

Publications (1)

Publication Number Publication Date
CN102459275A true CN102459275A (zh) 2012-05-16

Family

ID=43010633

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800284272A Pending CN102459275A (zh) 2009-04-24 2010-04-22 制备吗啡烷和吗啡酮化合物的方法

Country Status (11)

Country Link
US (1) US8853401B2 (https=)
EP (1) EP2421868A4 (https=)
JP (1) JP5824448B2 (https=)
KR (1) KR20120088537A (https=)
CN (1) CN102459275A (https=)
AU (1) AU2010239059B2 (https=)
CA (1) CA2758231A1 (https=)
IL (1) IL215553A (https=)
MX (1) MX2011011245A (https=)
NZ (1) NZ595591A (https=)
WO (1) WO2010121369A1 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105777765A (zh) * 2014-12-15 2016-07-20 北大方正集团有限公司 一种乙酰化溴甲纳曲酮及其制备方法
CN105777767A (zh) * 2014-12-15 2016-07-20 北大方正集团有限公司 一种乙酰化Delta-7溴甲纳曲酮及其制备方法
CN111777617A (zh) * 2020-07-10 2020-10-16 华润三九医药股份有限公司 一种溴甲纳曲酮的精制方法
CN114502560A (zh) * 2020-12-18 2022-05-13 四川大学 一种新型中间体及其制备方法和应用
WO2022127321A1 (zh) * 2020-12-18 2022-06-23 四川大学 一种新型中间体及其制备方法和应用

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010017573A1 (en) * 2008-08-11 2010-02-18 Tasmanian Alkaloids Pty Limited PROCESS FOR MAKING MORPHINAN-6α-OLS
CN102558188B (zh) * 2010-12-17 2014-07-23 北大方正集团有限公司 一种溴甲纳曲酮的制备方法
CN102558189B (zh) * 2010-12-17 2014-09-03 北大方正集团有限公司 溴甲纳曲酮的精制方法
CA2833283A1 (en) * 2011-05-02 2012-11-08 Brock University Processes and intermediates in the preparation of morphine analogs via n-demethylation of n-oxides using cyclodehydration reagents
AU2012253188B2 (en) * 2011-05-06 2016-12-22 Brock University Process for the preparation of morphine analogs via metal catalyzed N-demethylation/functionalization and intramolecular group transfer
US8981098B2 (en) 2012-02-03 2015-03-17 Brock University Process for the preparation of morphine analogs via the reaction of organometallic reagents with an oxazolidine derived from morphinans
US9701688B2 (en) 2014-05-05 2017-07-11 Noramco, Inc. Process for the preparation of opioid compounds
US9701687B2 (en) 2014-05-05 2017-07-11 Noramco, Inc. Process for the preparation of opioid compounds
EP3023427A1 (en) * 2014-11-19 2016-05-25 Siegfried AG Improved method of manufacturing buprenorphine and analogues thereof from oripavine
WO2018211331A1 (en) * 2017-05-19 2018-11-22 Evolva Sa Preparation of buprenorphine

Citations (2)

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CA2671518A1 (en) * 2006-12-04 2008-06-12 Noramco, Inc. Process for preparing oxycodone having reduced levels of 14-hydroxycodeinone
CN101570539A (zh) * 2009-06-01 2009-11-04 漆又毛 一种吗啡酮季铵盐衍生物及其制备方法

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US4176186A (en) 1978-07-28 1979-11-27 Boehringer Ingelheim Gmbh Quaternary derivatives of noroxymorphone which relieve intestinal immobility
ES2127532T3 (es) 1994-05-31 1999-04-16 Mallinckrodt Chemical Inc Preparacion de nalbufina con niveles bajos del epimero beta.
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CN101570539A (zh) * 2009-06-01 2009-11-04 漆又毛 一种吗啡酮季铵盐衍生物及其制备方法

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105777765A (zh) * 2014-12-15 2016-07-20 北大方正集团有限公司 一种乙酰化溴甲纳曲酮及其制备方法
CN105777767A (zh) * 2014-12-15 2016-07-20 北大方正集团有限公司 一种乙酰化Delta-7溴甲纳曲酮及其制备方法
CN111777617A (zh) * 2020-07-10 2020-10-16 华润三九医药股份有限公司 一种溴甲纳曲酮的精制方法
CN114502560A (zh) * 2020-12-18 2022-05-13 四川大学 一种新型中间体及其制备方法和应用
WO2022127321A1 (zh) * 2020-12-18 2022-06-23 四川大学 一种新型中间体及其制备方法和应用
WO2022127320A1 (zh) * 2020-12-18 2022-06-23 四川大学 一种中间体及其制备方法和应用

Also Published As

Publication number Publication date
IL215553A0 (en) 2011-12-29
CA2758231A1 (en) 2010-10-28
NZ595591A (en) 2013-11-29
MX2011011245A (es) 2012-04-11
JP2012524726A (ja) 2012-10-18
AU2010239059B2 (en) 2016-06-09
US8853401B2 (en) 2014-10-07
EP2421868A4 (en) 2012-08-01
WO2010121369A1 (en) 2010-10-28
US20120046465A1 (en) 2012-02-23
EP2421868A1 (en) 2012-02-29
KR20120088537A (ko) 2012-08-08
AU2010239059A1 (en) 2011-10-27
IL215553A (en) 2015-01-29
JP5824448B2 (ja) 2015-11-25

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Application publication date: 20120516