KR20120083510A - 글루카곤-유사 단백질-1 수용기(ｇｌｐ-1ｒ) 작용제 화합물 - Google Patents

글루카곤-유사 단백질-1 수용기(ｇｌｐ-1ｒ) 작용제 화합물 Download PDF

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KR20120083510A
KR20120083510A KR1020127014446A KR20127014446A KR20120083510A KR 20120083510 A KR20120083510 A KR 20120083510A KR 1020127014446 A KR1020127014446 A KR 1020127014446A KR 20127014446 A KR20127014446 A KR 20127014446A KR 20120083510 A KR20120083510 A KR 20120083510A
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seq
substituted
group
unsubstituted
antibody
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Korean (ko)
Inventor
커트 브래드쇼우
수쿠마르 사카무리
얀웬 푸
브리얀 오아테스
조엘 데샤르나이스
데이비드 투멜티
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씨오브이엑스 테크놀로지스 아일랜드 리미티드
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Publication of KR20120083510A publication Critical patent/KR20120083510A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6843—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020127014446A 2007-01-05 2008-01-07 글루카곤-유사 단백질-1 수용기(ｇｌｐ-1ｒ) 작용제 화합물 Ceased KR20120083510A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US87904807P 2007-01-05 2007-01-05
US60/879,048 2007-01-05
US93983107P 2007-05-23 2007-05-23
US60/939,831 2007-05-23
US94531907P 2007-06-20 2007-06-20
US60/945,319 2007-06-20

Related Parent Applications (1)

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KR1020097013938A Division KR101224335B1 (ko) 2007-01-05 2008-01-07 글루카곤-유사 단백질-1 수용기(ｇｌｐ-1ｒ) 작용제 화합물

Publications (1)

Publication Number Publication Date
KR20120083510A true KR20120083510A (ko) 2012-07-25

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KR1020097013938A Expired - Fee Related KR101224335B1 (ko) 2007-01-05 2008-01-07 글루카곤-유사 단백질-1 수용기(ｇｌｐ-1ｒ) 작용제 화합물
KR1020127014446A Ceased KR20120083510A (ko) 2007-01-05 2008-01-07 글루카곤-유사 단백질-1 수용기(ｇｌｐ-1ｒ) 작용제 화합물

Family Applications Before (1)

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KR1020097013938A Expired - Fee Related KR101224335B1 (ko) 2007-01-05 2008-01-07 글루카곤-유사 단백질-1 수용기(ｇｌｐ-1ｒ) 작용제 화합물

Country Status (10)

Country Link
US (1) US20090098130A1 (enExample)
EP (1) EP2118131A1 (enExample)
JP (2) JP5009376B2 (enExample)
KR (2) KR101224335B1 (enExample)
AU (1) AU2008203641B2 (enExample)
BR (1) BRPI0806308A2 (enExample)
CA (1) CA2674112A1 (enExample)
MX (1) MX2009007290A (enExample)
NZ (1) NZ577686A (enExample)
WO (1) WO2008081418A1 (enExample)

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AU2008203641B2 (en) 2011-10-06
JP2012184232A (ja) 2012-09-27
KR20090096498A (ko) 2009-09-10
US20090098130A1 (en) 2009-04-16
WO2008081418A1 (en) 2008-07-10
BRPI0806308A2 (pt) 2011-09-06
EP2118131A1 (en) 2009-11-18
AU2008203641A1 (en) 2008-07-10
KR101224335B1 (ko) 2013-01-25
NZ577686A (en) 2011-11-25
JP2010514835A (ja) 2010-05-06
MX2009007290A (es) 2009-07-14
CA2674112A1 (en) 2008-07-10
JP5009376B2 (ja) 2012-08-22

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