KR20120081990A - 이미노당 및 필로바이러스 질환의 치료 방법 - Google Patents
이미노당 및 필로바이러스 질환의 치료 방법 Download PDFInfo
- Publication number
- KR20120081990A KR20120081990A KR1020127007711A KR20127007711A KR20120081990A KR 20120081990 A KR20120081990 A KR 20120081990A KR 1020127007711 A KR1020127007711 A KR 1020127007711A KR 20127007711 A KR20127007711 A KR 20127007711A KR 20120081990 A KR20120081990 A KR 20120081990A
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- South Korea
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- virus
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- Prior art date
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- Ceased
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Images
Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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- Epidemiology (AREA)
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- Virology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| US27225309P | 2009-09-04 | 2009-09-04 | |
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| US28250710P | 2010-02-22 | 2010-02-22 | |
| US61/282,507 | 2010-02-22 |
Publications (1)
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| KR20120081990A true KR20120081990A (ko) | 2012-07-20 |
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| CA (1) | CA2772813A1 (enExample) |
| ES (1) | ES2527623T3 (enExample) |
| WO (1) | WO2011028779A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102655746B (zh) | 2009-02-23 | 2016-08-03 | 联合治疗公司 | 亚氨基糖以及治疗病毒性疾病的方法 |
| WO2013148791A1 (en) * | 2012-03-28 | 2013-10-03 | Institute For Hepatitis And Virus Research | Novel alkylated imino sugars exhibiting glucosidase inhibition and their method of use |
| EP2858642A4 (en) | 2012-06-06 | 2015-12-02 | Unither Virology Llc | NOVEL IMINO SUGAR AND ITS APPLICATIONS |
| CA2911149A1 (en) * | 2013-05-02 | 2014-11-06 | The Chancellor, Masters And Scholars Of The University Of Oxford | Glycolipid inhibition using iminosugars |
| MX2016003323A (es) | 2013-09-16 | 2016-08-12 | Emergent Virology Llc | Derivados de dosoxinojirimicina y sus metodos de uso. |
| WO2016051396A1 (en) * | 2014-09-30 | 2016-04-07 | Susan Eve Vecht-Lifshitz | Pharmaceutical compositions for treating ebola virus disease |
| JP6826986B2 (ja) | 2014-11-05 | 2021-02-10 | エマージェント バイロロジー エルエルシー | ウィルス性疾患の治療に有用なイミノ糖類 |
| CN109628647A (zh) * | 2019-02-02 | 2019-04-16 | 广州市妇女儿童医疗中心 | 抗病毒药物筛选方法及其应用 |
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| GB1555654A (en) * | 1977-06-25 | 1979-11-14 | Exxon Research Engineering Co | Agricultural burner apparatus |
| NO154918C (no) * | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
| DE2834122A1 (de) * | 1978-08-03 | 1980-02-14 | Bayer Ag | Verfahren zur herstellung von 6-amino-6-desoxy-l-sorbose |
| DE2839309A1 (de) * | 1978-09-09 | 1980-03-27 | Bayer Ag | 3,4,5-trihydroxypiperidin-derivate |
| DE2853573A1 (de) | 1978-12-12 | 1980-07-03 | Bayer Ag | Herstellung von n-substituierten derivaten des l-desoxynojirimycins |
| DE3038901A1 (de) * | 1980-10-15 | 1982-05-06 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von n-substituierten derivaten des 1-desoxynojirimycins |
| DE3611841A1 (de) * | 1986-04-09 | 1987-10-15 | Bayer Ag | Verfahren zur herstellung von 1-desoxynojirimycin und dessen n-derivaten |
| US5043273A (en) * | 1989-08-17 | 1991-08-27 | Monsanto Company | Phosphorylated glycosidase inhibitor prodrugs |
| US5103008A (en) * | 1989-08-17 | 1992-04-07 | Monsanto Company | Compound, N-butyl-deoxynojirimycin-6-phosphate |
| US4994572A (en) * | 1989-10-12 | 1991-02-19 | Monsanto Company | Synthesis of nojirimycin derivatives |
| US5030638A (en) * | 1990-02-26 | 1991-07-09 | G. D. Searle & Co. | Method of antiviral enhancement |
| US5200523A (en) | 1990-10-10 | 1993-04-06 | Monsanto Company | Synthesis of nojirimycin derivatives |
| ZA931934B (en) | 1992-03-18 | 1993-03-18 | Us Bioscience | Compostitions of N-(phosphonoacetyl)-L-aspartic acid and methods of their use as broad spectrum antivirals |
| US5206251A (en) * | 1992-04-01 | 1993-04-27 | G. D. Searle & Co. | 2- and 3- amino and azido derivatives of 1,5-iminosugars |
| US5399567A (en) * | 1993-05-13 | 1995-03-21 | Monsanto Company | Method of treating cholera |
| AU1876095A (en) * | 1994-02-25 | 1995-09-11 | G.D. Searle & Co. | Use of 1-deoxynojirimycin and its derivatives for treating mammals infected with respiratory syncytial virus |
| CA2312423A1 (en) | 1997-12-11 | 1999-06-17 | The Chancellor, Masters And Scholars Of The University Of Oxford | Inhibition of membrane-associated viral replication |
| US6689759B1 (en) * | 1998-02-12 | 2004-02-10 | G. D. Searle & Co. | Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy |
| US6610703B1 (en) * | 1998-12-10 | 2003-08-26 | G.D. Searle & Co. | Method for treatment of glycolipid storage diseases |
| GB9828474D0 (en) | 1998-12-24 | 1999-02-17 | British Aerospace | Surface topology inspection |
| CA2362914C (en) * | 1999-02-12 | 2009-04-14 | G.D. Searle & Co. | Use of substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections |
| GB0100889D0 (en) * | 2001-01-12 | 2001-02-21 | Oxford Glycosciences Uk Ltd | Compounds |
| ATE234626T1 (de) * | 1999-07-26 | 2003-04-15 | Searle & Co | Verwendung von langkettigen n-alkyl derivaten von deoxynojirimycin mit glucocerebrosidase enzyme zur herstellung eines medikaments zur behandlung von mit glykolipiden akkumulation zusammenhängenden krankheiten |
| US7256005B2 (en) * | 1999-08-10 | 2007-08-14 | The Chancellor, Masters And Scholars Of The University Of Oxford | Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity |
| CN1756558B (zh) * | 2003-01-31 | 2012-04-25 | 纽约大学西奈山医学院 | 酶和酶的活性部位特异性陪伴分子的组合 |
| US7446098B2 (en) * | 2003-02-18 | 2008-11-04 | Mount Sinai School Of Medicine Of New York University | Combination therapy for treating protein deficiencies |
| US20050256168A1 (en) * | 2004-04-28 | 2005-11-17 | Block Timothy M | Compositions for oral administration for the treatment of interferon-responsive disorders |
| US7524829B2 (en) * | 2004-11-01 | 2009-04-28 | Avi Biopharma, Inc. | Antisense antiviral compounds and methods for treating a filovirus infection |
| GB0501352D0 (en) * | 2005-01-21 | 2005-03-02 | Slingsby Jason H | Use of glycosylation modulators in combination with membrane fusion inhibitors for treatment of infections caused by viruses bearing glycosylated envelope |
| JP2008533175A (ja) * | 2005-03-16 | 2008-08-21 | ユニバーシティ・オブ・オックスフォード | Ｈｉｖ−１のためのマンノース免疫原 |
| JP2008545657A (ja) * | 2005-05-17 | 2008-12-18 | アミカス セラピューティックス インコーポレイテッド | １−デオキシノジリマイシンおよび誘導体を用いるポンペ病の治療方法 |
| JP2009507770A (ja) * | 2005-07-27 | 2009-02-26 | ユニバーシティ オブ フロリダ リサーチ ファウンデーション，インコーポレイティド | 眼性疾患の治療への、熱ショックの使用 |
| JP2009502954A (ja) * | 2005-07-27 | 2009-01-29 | ユニバーシティ オブ フロリダ リサーチ ファウンデーション，インコーポレイティド | タンパク質のミスフォールディングを修正する小分子及びその使用 |
| US20070244184A1 (en) * | 2006-01-09 | 2007-10-18 | Simon Fraser University | Glycosidase inhibitors and methods of synthesizing same |
| DE602007008870D1 (de) * | 2006-04-24 | 2010-10-14 | Amc Amsterdam | Verbessertes verfahren zur behandlung von cystischer fibrose |
| JP5241709B2 (ja) * | 2006-05-24 | 2013-07-17 | ユナイテッド セラピューティクス コーポレーション | デオキシノジリマイシンおよびｄ−アラビニトールのアナログおよび使用方法 |
| WO2008088581A2 (en) * | 2006-08-02 | 2008-07-24 | United Therapeutics Corporation | Liposome treatment of viral infections |
| EP2054076A2 (en) * | 2006-08-21 | 2009-05-06 | United Therapeutics Corporation | Combination therapy for treatment of viral infections |
| CA2719567A1 (en) * | 2008-03-26 | 2009-10-01 | University Of Oxford | Endoplasmic reticulum targeting liposomes |
| WO2010027996A1 (en) * | 2008-09-02 | 2010-03-11 | Institute For Hepatitis And Virus Research | Novel imino sugar derivatives demonstrate potent antiviral activity and reduced toxicity |
| KR20120059447A (ko) * | 2009-03-27 | 2012-06-08 | 더 챈슬러 마스터즈 앤드 스칼라스 오브 더 유니버시티 오브 옥스포드 | 콜레스테롤 수준 저하 리포좀 |
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- 2010-09-01 JP JP2012528004A patent/JP5752689B2/ja not_active Expired - Fee Related
- 2010-09-01 WO PCT/US2010/047493 patent/WO2011028779A1/en not_active Ceased
- 2010-09-01 KR KR1020127007711A patent/KR20120081990A/ko not_active Ceased
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- 2010-09-01 US US12/873,708 patent/US20110065754A1/en not_active Abandoned
- 2010-09-01 CN CN2010800483990A patent/CN102595895A/zh active Pending
- 2010-09-01 CA CA2772813A patent/CA2772813A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20110065754A1 (en) | 2011-03-17 |
| CN102595895A (zh) | 2012-07-18 |
| JP2013503881A (ja) | 2013-02-04 |
| WO2011028779A1 (en) | 2011-03-10 |
| EP2473046B1 (en) | 2014-10-22 |
| CN105748476A (zh) | 2016-07-13 |
| EP2473046A4 (en) | 2013-04-24 |
| EP2473046A1 (en) | 2012-07-11 |
| JP5752689B2 (ja) | 2015-07-22 |
| CA2772813A1 (en) | 2011-03-10 |
| ES2527623T3 (es) | 2015-01-27 |
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