ES2527623T3 - Iminoazúcares para su uso en el tratamiento de enfermedades por filovirus - Google Patents

Iminoazúcares para su uso en el tratamiento de enfermedades por filovirus Download PDF

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Publication number
ES2527623T3
ES2527623T3 ES10814412.2T ES10814412T ES2527623T3 ES 2527623 T3 ES2527623 T3 ES 2527623T3 ES 10814412 T ES10814412 T ES 10814412T ES 2527623 T3 ES2527623 T3 ES 2527623T3
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ES
Spain
Prior art keywords
substituted
unsubstituted
groups
formula
alkyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES10814412.2T
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English (en)
Spanish (es)
Inventor
Urban Ramstedt
Brennan Klose
Nicole Zitzmann
Raymond A. Dwek
Terry D. Butters
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Oxford
United Therapeutics Corp
Original Assignee
University of Oxford
United Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by University of Oxford, United Therapeutics Corp filed Critical University of Oxford
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Publication of ES2527623T3 publication Critical patent/ES2527623T3/es
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES10814412.2T 2009-09-04 2010-09-01 Iminoazúcares para su uso en el tratamiento de enfermedades por filovirus Active ES2527623T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US27225309P 2009-09-04 2009-09-04
US272253P 2009-09-04
US28250710P 2010-02-22 2010-02-22
US282507P 2010-02-22
PCT/US2010/047493 WO2011028779A1 (en) 2009-09-04 2010-09-01 Iminosugars and methods of treating filoviral diseases

Publications (1)

Publication Number Publication Date
ES2527623T3 true ES2527623T3 (es) 2015-01-27

Family

ID=43649618

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10814412.2T Active ES2527623T3 (es) 2009-09-04 2010-09-01 Iminoazúcares para su uso en el tratamiento de enfermedades por filovirus

Country Status (8)

Country Link
US (1) US20110065754A1 (enExample)
EP (1) EP2473046B1 (enExample)
JP (1) JP5752689B2 (enExample)
KR (1) KR20120081990A (enExample)
CN (2) CN105748476A (enExample)
CA (1) CA2772813A1 (enExample)
ES (1) ES2527623T3 (enExample)
WO (1) WO2011028779A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2398321B1 (en) 2009-02-23 2015-11-25 United Therapeutics Corporation Iminosugars and methods of treating viral diseases
WO2013148791A1 (en) * 2012-03-28 2013-10-03 Institute For Hepatitis And Virus Research Novel alkylated imino sugars exhibiting glucosidase inhibition and their method of use
JP2015518896A (ja) 2012-06-06 2015-07-06 ユニザー ヴィロロジー，エルエルシー 新規イミノ糖およびそれらの用途
US20160075651A1 (en) * 2013-05-02 2016-03-17 Unither Virology, Llc Glycolipid inhibition using iminosugars
EP3046558B1 (en) 2013-09-16 2019-08-14 Emergent Virology LLC Deoxynojirimycin derivatives and methods of their using
EP3200826B1 (en) * 2014-09-30 2021-04-21 Vecht-lifshitz, Susan Eve Pharmaceutical compositions for treating ebola virus disease
US10428022B2 (en) 2014-11-05 2019-10-01 Emergent Virology Llc Iminosugars useful for the treatment of viral diseases
CN109628647A (zh) * 2019-02-02 2019-04-16 广州市妇女儿童医疗中心 抗病毒药物筛选方法及其应用

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DE2834122A1 (de) * 1978-08-03 1980-02-14 Bayer Ag Verfahren zur herstellung von 6-amino-6-desoxy-l-sorbose
DE2839309A1 (de) * 1978-09-09 1980-03-27 Bayer Ag 3,4,5-trihydroxypiperidin-derivate
DE2853573A1 (de) * 1978-12-12 1980-07-03 Bayer Ag Herstellung von n-substituierten derivaten des l-desoxynojirimycins
DE3038901A1 (de) 1980-10-15 1982-05-06 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von n-substituierten derivaten des 1-desoxynojirimycins
DE3611841A1 (de) * 1986-04-09 1987-10-15 Bayer Ag Verfahren zur herstellung von 1-desoxynojirimycin und dessen n-derivaten
US5043273A (en) 1989-08-17 1991-08-27 Monsanto Company Phosphorylated glycosidase inhibitor prodrugs
US5103008A (en) 1989-08-17 1992-04-07 Monsanto Company Compound, N-butyl-deoxynojirimycin-6-phosphate
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US5200523A (en) 1990-10-10 1993-04-06 Monsanto Company Synthesis of nojirimycin derivatives
ZA931934B (en) 1992-03-18 1993-03-18 Us Bioscience Compostitions of N-(phosphonoacetyl)-L-aspartic acid and methods of their use as broad spectrum antivirals
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US7256005B2 (en) * 1999-08-10 2007-08-14 The Chancellor, Masters And Scholars Of The University Of Oxford Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity
ES2619353T3 (es) * 2003-01-31 2017-06-26 Mount Sinai School Of Medicine Of New York University Terapia de combinación para tratar trastornos de deficiencia de proteínas
US7446098B2 (en) * 2003-02-18 2008-11-04 Mount Sinai School Of Medicine Of New York University Combination therapy for treating protein deficiencies
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US20100004156A1 (en) * 2005-07-27 2010-01-07 Shalesh Kaushal Small Compounds That Correct Protein Misfolding and Uses Thereof
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DE602007008870D1 (de) * 2006-04-24 2010-10-14 Amc Amsterdam Verbessertes verfahren zur behandlung von cystischer fibrose
ES2537572T3 (es) * 2006-05-24 2015-06-09 United Therapeutics Corporation Análogos de desoxinojirimicina y D-arabinitol y métodos de uso
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WO2008063727A2 (en) * 2006-08-21 2008-05-29 United Therapeutics Corporation Combination therapy for treatment of viral infections
US20090252785A1 (en) 2008-03-26 2009-10-08 University Of Oxford Endoplasmic reticulum targeting liposomes
WO2010027996A1 (en) * 2008-09-02 2010-03-11 Institute For Hepatitis And Virus Research Novel imino sugar derivatives demonstrate potent antiviral activity and reduced toxicity
KR20120059447A (ko) * 2009-03-27 2012-06-08 더 챈슬러 마스터즈 앤드 스칼라스 오브 더 유니버시티 오브 옥스포드 콜레스테롤 수준 저하 리포좀

Also Published As

Publication number Publication date
EP2473046A4 (en) 2013-04-24
CA2772813A1 (en) 2011-03-10
WO2011028779A1 (en) 2011-03-10
CN102595895A (zh) 2012-07-18
KR20120081990A (ko) 2012-07-20
EP2473046A1 (en) 2012-07-11
US20110065754A1 (en) 2011-03-17
EP2473046B1 (en) 2014-10-22
CN105748476A (zh) 2016-07-13
JP5752689B2 (ja) 2015-07-22
JP2013503881A (ja) 2013-02-04

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