KR20120007059A - 4―（3―클로로―2―플루오로―아닐리노）―7―메톡시―6―［［1―（ｎ―메틸카르바모일메틸）―피페리딘―4―일］옥시］퀴나졸린의 제조 방법 - Google Patents

4―（3―클로로―2―플루오로―아닐리노）―7―메톡시―6―［［1―（ｎ―메틸카르바모일메틸）―피페리딘―4―일］옥시］퀴나졸린의 제조 방법 Download PDF

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Publication number
KR20120007059A
KR20120007059A KR1020117027878A KR20117027878A KR20120007059A KR 20120007059 A KR20120007059 A KR 20120007059A KR 1020117027878 A KR1020117027878 A KR 1020117027878A KR 20117027878 A KR20117027878 A KR 20117027878A KR 20120007059 A KR20120007059 A KR 20120007059A
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KR
South Korea
Prior art keywords
compound
formula
chloro
acid
iii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020117027878A
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English (en)
Korean (ko)
Inventor
카이 알리슨 보드만
올리버 로버트 쿠닝햄
윌리엄 군드라이
데이비드 더모트 패트릭 라판
Original Assignee
아스트라제네카 아베
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Publication date
Application filed by 아스트라제네카 아베 filed Critical 아스트라제네카 아베
Publication of KR20120007059A publication Critical patent/KR20120007059A/ko
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/12—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR1020117027878A 2009-04-23 2010-04-22 4―（3―클로로―2―플루오로―아닐리노）―7―메톡시―6―［［1―（ｎ―메틸카르바모일메틸）―피페리딘―4―일］옥시］퀴나졸린의 제조 방법 Withdrawn KR20120007059A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17199409P 2009-04-23 2009-04-23
US61/171,994 2009-04-23

Publications (1)

Publication Number Publication Date
KR20120007059A true KR20120007059A (ko) 2012-01-19

Family

ID=42224659

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020117027878A Withdrawn KR20120007059A (ko) 2009-04-23 2010-04-22 4―（3―클로로―2―플루오로―아닐리노）―7―메톡시―6―［［1―（ｎ―메틸카르바모일메틸）―피페리딘―4―일］옥시］퀴나졸린의 제조 방법

Country Status (14)

Country Link
US (1) US8450482B2 (enExample)
EP (1) EP2421827A2 (enExample)
JP (1) JP2012524769A (enExample)
KR (1) KR20120007059A (enExample)
CN (1) CN102459174A (enExample)
AR (1) AR076407A1 (enExample)
AU (1) AU2010240717A1 (enExample)
BR (1) BRPI1013854A2 (enExample)
CA (1) CA2758610A1 (enExample)
IL (1) IL215388A0 (enExample)
MX (1) MX2011011177A (enExample)
SG (1) SG174893A1 (enExample)
TW (1) TW201041871A (enExample)
WO (1) WO2010122340A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101272613B1 (ko) 2011-10-05 2013-06-10 한미사이언스 주식회사 1-(4-(4-(3,4-디클로로-2-플루오로페닐아미노)-7-메톡시퀴나졸린-6-일옥시)피페리딘-1-일)프로프-2-엔-1-온 염산염의 제조 방법 및 이에 사용되는 중간체
CN108503596A (zh) * 2018-03-14 2018-09-07 盐城师范学院 一种新的厄洛替尼及其中间体的制备方法
CN108440420A (zh) * 2018-03-22 2018-08-24 盐城师范学院 酪氨酸激酶抑制剂拉帕替尼及其关键中间体的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI324597B (en) 2002-03-28 2010-05-11 Astrazeneca Ab Quinazoline derivatives
US6924285B2 (en) 2002-03-30 2005-08-02 Boehringer Ingelheim Pharma Gmbh & Co. Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
GB0320793D0 (en) * 2003-09-05 2003-10-08 Astrazeneca Ab Chemical process
JP4036885B2 (ja) 2003-09-19 2008-01-23 アストラゼネカ アクチボラグ キナゾリン誘導体
US20070299092A1 (en) * 2004-05-20 2007-12-27 Wyeth Quinone Substituted Quinazoline and Quinoline Kinase Inhibitors
WO2009138779A1 (en) * 2008-05-13 2009-11-19 Astrazeneca Ab Combination comprising 4- (3-chloro-2-fluoroanilino) -7-meth0xy-6- { [1- (n-methylcarbamoylmethyl) piperidin- 4-yl] oxyjquinazoline
BRPI0912170A2 (pt) * 2008-05-13 2015-10-13 Astrazeneca Ab composto, forma a, processo para a preparação da mesma, composição farmacêutica, uso de um composto, e, método para tratar um câncer em um animal de sangue quente

Also Published As

Publication number Publication date
WO2010122340A8 (en) 2011-12-15
SG174893A1 (en) 2011-11-28
EP2421827A2 (en) 2012-02-29
AU2010240717A1 (en) 2011-10-27
JP2012524769A (ja) 2012-10-18
AR076407A1 (es) 2011-06-08
MX2011011177A (es) 2011-11-18
TW201041871A (en) 2010-12-01
IL215388A0 (en) 2011-12-29
WO2010122340A3 (en) 2011-09-09
CN102459174A (zh) 2012-05-16
US20120108814A1 (en) 2012-05-03
US8450482B2 (en) 2013-05-28
BRPI1013854A2 (pt) 2017-05-16
CA2758610A1 (en) 2010-10-28
WO2010122340A2 (en) 2010-10-28

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PA0105 International application

Patent event date: 20111122

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid