KR20120006544A - Ｃｃｒ2의 4-아제티디닐-1-페닐-사이클로헥산 길항제 - Google Patents

Ｃｃｒ2의 4-아제티디닐-1-페닐-사이클로헥산 길항제 Download PDF

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KR20120006544A
KR20120006544A KR1020117026846A KR20117026846A KR20120006544A KR 20120006544 A KR20120006544 A KR 20120006544A KR 1020117026846 A KR1020117026846 A KR 1020117026846A KR 20117026846 A KR20117026846 A KR 20117026846A KR 20120006544 A KR20120006544 A KR 20120006544A
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alkyl
phenyl
prepared
och
nmr
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쑤큉 장
헤더 래이 후프나젤
쿠이펜 호우
다나 엘. 존슨
지후아 수이
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얀센 파마슈티카 엔.브이.
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KR1020117026846A 2009-04-17 2010-04-15 Ｃｃｒ2의 4-아제티디닐-1-페닐-사이클로헥산 길항제 Withdrawn KR20120006544A (ko)

Applications Claiming Priority (2)

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US17030709P 2009-04-17 2009-04-17
US61/170,307 2009-04-17

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KR20120006544A true KR20120006544A (ko) 2012-01-18

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US (2) US20100267689A1 (https=)
EP (1) EP2419419B1 (https=)
JP (1) JP5675773B2 (https=)
KR (1) KR20120006544A (https=)
CN (1) CN102459227B (https=)
AR (1) AR076328A1 (https=)
AU (1) AU2010236346B2 (https=)
BR (1) BRPI1016189A2 (https=)
CA (1) CA2758934A1 (https=)
ES (1) ES2528625T3 (https=)
MX (1) MX2011010964A (https=)
NZ (1) NZ595432A (https=)
TW (1) TW201102377A (https=)
WO (1) WO2010121046A1 (https=)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010068663A1 (en) * 2008-12-10 2010-06-17 Janssen Pharmaceutica Nv 4-azetidinyl-1-heteroaryl-cyclohexanol antagonists of ccr2
MX2011010919A (es) * 2009-04-16 2011-11-02 Janssen Pharmaceutica Nv Antagonistas del receptor 2 de citocina quimioatrayente de 4-azetidinil-1-heteroaril-ciclohexano.
WO2010121036A1 (en) 2009-04-17 2010-10-21 Janssen Pharmaceutica Nv 4-azetidinyl-1-heteroatom linked-cyclohexane antagonists of ccr2
CN102459227B (zh) 2009-04-17 2014-08-20 詹森药业有限公司 Ccr2的4-氮杂环丁烷基-1-苯基-环己烷拮抗剂
TW201211027A (en) * 2010-06-09 2012-03-16 Janssen Pharmaceutica Nv Cyclohexyl-azetidinyl antagonists of CCR2
TW201204717A (en) 2010-06-17 2012-02-01 Janssen Pharmaceutica Nv Cyclohexyl-azetidinyl antagonists of CCR2
CA2852160A1 (en) 2011-10-28 2013-05-02 Galderma Research & Development New leukocyte infiltrate markers for rosacea and uses thereof
AU2012338581B2 (en) 2011-11-18 2016-12-08 Nxera Pharma Uk Limited Muscarinic M1 receptor agonists
DK2785710T3 (en) * 2011-12-01 2017-12-04 Chemocentryx Inc SUBSTITUTED BENZIMIDAZOLES AND BENZOPYRAZOLES AS CCR (4) - ANTAGONISTS
ES2690315T3 (es) 2012-06-15 2018-11-20 Mitsubishi Tanabe Pharma Corporation Compuestos de imidazol y triazol como inhibidores de DGAT-1
GB201404922D0 (en) 2014-03-19 2014-04-30 Heptares Therapeutics Ltd Pharmaceutical compounds
KR20200087273A (ko) 2014-10-24 2020-07-20 란도스 바이오파마, 인크. 란티오닌 합성효소 c-유사 2-계 치료제
ES2764840T3 (es) 2015-01-28 2020-06-04 Univ Bordeaux Uso de plerixafor para tratar y/o prevenir exacerbaciones agudas de la enfermedad pulmonar obstructiva crónica
ES2904252T3 (es) 2015-05-21 2022-04-04 Chemocentryx Inc Moduladores de CCR2
GB201513743D0 (en) 2015-08-03 2015-09-16 Heptares Therapeutics Ltd Muscarinic agonists
GB201519352D0 (en) 2015-11-02 2015-12-16 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201617454D0 (en) 2016-10-14 2016-11-30 Heptares Therapeutics Limited Pharmaceutical compounds
US10259787B2 (en) 2016-10-14 2019-04-16 Heptares Therapeutics Limited Substituted cyclohexanes as muscarinic M1 receptor and/or M4 receptor agonists
CN118267479A (zh) 2017-09-25 2024-07-02 凯莫森特里克斯股份有限公司 使用趋化因子受体2(ccr2)拮抗剂和pd-1/pd-l1抑制剂的联合治疗
BR112020010983A2 (pt) 2017-11-30 2020-11-17 Landos Biopharma, Inc método in vitro para gerar células preparadas a partir de células precursoras, células isoladas e método para tratar uma afecção em um animal com as células isoladas
IL275898B2 (en) 2018-01-08 2025-05-01 Chemocentryx Inc Methods for treating solid tumors with CCR2 antagonists
US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists
GB201810239D0 (en) 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819961D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB202020191D0 (en) 2020-12-18 2021-02-03 Heptares Therapeutics Ltd Pharmaceutical compounds
CN110028395A (zh) * 2019-05-29 2019-07-19 宁夏中星显示材料有限公司 一种4-(4-羟基苯基)环己酮的制备方法
BR112022002387A2 (pt) 2019-12-20 2022-09-06 Landos Biopharma Inc Composto da fórmula z-y-q-y' ou um sal ou éster farmaceuticamente aceitável do mesmo

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998057641A1 (en) 1997-06-18 1998-12-23 Merck & Co., Inc. ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS
US6037354A (en) * 1997-06-18 2000-03-14 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonists
AU4796700A (en) * 1999-05-13 2000-12-05 Dupont Pharmaceuticals Research Laboratories, Inc. Ureido-substituted cyclic amine derivatives and their use as drug
US7576117B1 (en) 1999-08-04 2009-08-18 Teijin Limited Cyclic amine CCR3 antagonist
EP1228065A1 (en) 1999-11-08 2002-08-07 Wyeth (indol-3-yl)-cycloalkyl]-3-substituted azetidines for the treatment of central nervous system disorders
US6245799B1 (en) * 1999-11-08 2001-06-12 American Home Products Corp [(Indol-3-yl)-cycloalkyl]-3-substituted azetidines for the treatment of central nervous system disorders
WO2002060859A2 (en) * 2000-12-20 2002-08-08 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
WO2002077065A1 (de) * 2001-03-26 2002-10-03 Bayer Aktiengesellschaft Polycarbonat mit ausgeprägtem scherentzähungsverhalten
UA87449C2 (ru) * 2002-11-27 2009-07-27 Инсайт Корпорейшн Производные 3-аминопиролидина как модуляторы рецепторов хемокина
MXPA05005660A (es) * 2002-11-27 2005-10-18 Incyte Corp Derivados de 3-aminopirrolidina como moduladores de receptores de quimocina.
BRPI0417605B8 (pt) 2003-12-18 2021-05-25 Incyte Corp “n-[2-((3s)-3-{[4-hidróxi-4-(5-pirimidin-2- ilpiridin-2-il)ciclohexil]amino}-pirrolidin-1-il)-2- oxoetil]-3-(trifluor-metil)benzamida, ou um sal farmaceuticamente aceitável do mesmo e composição que o compreende”.
US20060069123A1 (en) * 2004-09-28 2006-03-30 Mingde Xia Substituted dipiperidine CCR2 antagonists
UY29219A1 (es) * 2004-11-22 2006-04-28 Incyte Corp Sales de la n-(2- (((3r)-1-(trans-4-hidroxi-4-(6-metoxipiridin-3-il)-cilohexil) pirrolidin-3-il)amino)-2-oxoetil)-3- (trifluorometil) benzamida
GB0513747D0 (en) 2005-07-06 2005-08-10 Merck Sharp & Dohme Therapeutic compounds
WO2007053498A1 (en) 2005-11-01 2007-05-10 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of ccr2
WO2007130712A1 (en) 2006-01-31 2007-11-15 Janssen Pharmaceutica, Nv Substituted dipiperidine as ccr2 antagonists for the treatment of inflammatory diseases
CL2007002958A1 (es) * 2006-10-12 2008-05-09 Epix Delaware Inc Compuestos derivados de heteroaril-carboxamida, antagonistas del receptor de quimioquina; composicion farmaceutica; y uso para el tratamiento o prevencion de enfermedades tales como rechazo de transplante de organos, artritis reumatoidea, lupus, entr
WO2009076512A1 (en) * 2007-12-11 2009-06-18 Epix Delaware, Inc. Carboxamidξ compounds and their use as chemokine receptor agonists
WO2010068663A1 (en) * 2008-12-10 2010-06-17 Janssen Pharmaceutica Nv 4-azetidinyl-1-heteroaryl-cyclohexanol antagonists of ccr2
MX2011010919A (es) * 2009-04-16 2011-11-02 Janssen Pharmaceutica Nv Antagonistas del receptor 2 de citocina quimioatrayente de 4-azetidinil-1-heteroaril-ciclohexano.
CN102459227B (zh) 2009-04-17 2014-08-20 詹森药业有限公司 Ccr2的4-氮杂环丁烷基-1-苯基-环己烷拮抗剂
WO2010121036A1 (en) * 2009-04-17 2010-10-21 Janssen Pharmaceutica Nv 4-azetidinyl-1-heteroatom linked-cyclohexane antagonists of ccr2

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US20120040960A1 (en) 2012-02-16
CA2758934A1 (en) 2010-10-21
AR076328A1 (es) 2011-06-01
EP2419419A1 (en) 2012-02-22
US20100267689A1 (en) 2010-10-21
MX2011010964A (es) 2011-11-02
EP2419419B1 (en) 2014-12-03
TW201102377A (en) 2011-01-16
US8513229B2 (en) 2013-08-20
ES2528625T3 (es) 2015-02-11
CN102459227A (zh) 2012-05-16
JP2012524111A (ja) 2012-10-11
JP5675773B2 (ja) 2015-02-25
NZ595432A (en) 2013-12-20
AU2010236346B2 (en) 2015-01-22
BRPI1016189A2 (pt) 2016-04-19
AU2010236346A1 (en) 2011-11-03
CN102459227B (zh) 2014-08-20

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