CN102459227B - Ccr2的4-氮杂环丁烷基-1-苯基-环己烷拮抗剂 - Google Patents
Ccr2的4-氮杂环丁烷基-1-苯基-环己烷拮抗剂 Download PDFInfo
- Publication number
- CN102459227B CN102459227B CN201080027641.6A CN201080027641A CN102459227B CN 102459227 B CN102459227 B CN 102459227B CN 201080027641 A CN201080027641 A CN 201080027641A CN 102459227 B CN102459227 B CN 102459227B
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- Prior art keywords
- alkyl
- phenyl
- methyl
- prepared
- azetidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 0 C*CC(C)NC(CNC(c1cc(C(F)(F)F)ccc1)=O)=O Chemical compound C*CC(C)NC(CNC(c1cc(C(F)(F)F)ccc1)=O)=O 0.000 description 1
- FYTMPPOAWMMTGA-UHFFFAOYSA-N CC(C)(C)OC(Nc(cc1)ccc1C(CC1)=CCC1=O)=O Chemical compound CC(C)(C)OC(Nc(cc1)ccc1C(CC1)=CCC1=O)=O FYTMPPOAWMMTGA-UHFFFAOYSA-N 0.000 description 1
- DUPKTFVNPHZWNC-UHFFFAOYSA-N CC(C)(C)OC(Nc1cccc(C(CC2)(CCC22OCCO2)O)c1)=O Chemical compound CC(C)(C)OC(Nc1cccc(C(CC2)(CCC22OCCO2)O)c1)=O DUPKTFVNPHZWNC-UHFFFAOYSA-N 0.000 description 1
- RVGRTRHVBFCARF-UHFFFAOYSA-N CC(C)(C)OC(Nc1cccc(C(CC2)(CCC2N(C2)CC2NC(CNC(c2cc(C(F)(F)F)ccc2)=O)=O)O)c1)=O Chemical compound CC(C)(C)OC(Nc1cccc(C(CC2)(CCC2N(C2)CC2NC(CNC(c2cc(C(F)(F)F)ccc2)=O)=O)O)c1)=O RVGRTRHVBFCARF-UHFFFAOYSA-N 0.000 description 1
- FHENRZKRAUSKEY-ARLHGKGLSA-N CC(CC[C@@H](C)N(C1)CC1NC(CN)=O)C1=CC=CCC1 Chemical compound CC(CC[C@@H](C)N(C1)CC1NC(CN)=O)C1=CC=CCC1 FHENRZKRAUSKEY-ARLHGKGLSA-N 0.000 description 1
- TWTISSNNQCPARJ-UHFFFAOYSA-N CCOC(c1cccc(C(CC2)CCC2=O)c1)=O Chemical compound CCOC(c1cccc(C(CC2)CCC2=O)c1)=O TWTISSNNQCPARJ-UHFFFAOYSA-N 0.000 description 1
- OUWPXYDIJLVUSG-UHFFFAOYSA-N COc1cc(C(CC2)(CCC2=O)O)ccc1 Chemical compound COc1cc(C(CC2)(CCC2=O)O)ccc1 OUWPXYDIJLVUSG-UHFFFAOYSA-N 0.000 description 1
- XUXGRGHZAIOCSD-UHFFFAOYSA-N COc1cccc(C(CC2)(CCC2N(C2)CC2NC(CNC(c2cc(C(F)(F)F)ccc2)=O)=O)N)c1 Chemical compound COc1cccc(C(CC2)(CCC2N(C2)CC2NC(CNC(c2cc(C(F)(F)F)ccc2)=O)=O)N)c1 XUXGRGHZAIOCSD-UHFFFAOYSA-N 0.000 description 1
- YODHYTBRRINSKP-UHFFFAOYSA-N COc1ccccc1C(CC1)(CCC1N(C1)CC1NC(CNC(c1cc(C(F)(F)F)ccc1)=C)=O)O Chemical compound COc1ccccc1C(CC1)(CCC1N(C1)CC1NC(CNC(c1cc(C(F)(F)F)ccc1)=C)=O)O YODHYTBRRINSKP-UHFFFAOYSA-N 0.000 description 1
- ZRUKZXVNNVHEBW-UHFFFAOYSA-N C[n]1c(cc(C(CC2)(CCC2=O)O)cc2)c2nc1 Chemical compound C[n]1c(cc(C(CC2)(CCC2=O)O)cc2)c2nc1 ZRUKZXVNNVHEBW-UHFFFAOYSA-N 0.000 description 1
- COHHDKBOPDVULP-UHFFFAOYSA-N Cc1ccc(C(CC2)(CCC2=O)O)cc1 Chemical compound Cc1ccc(C(CC2)(CCC2=O)O)cc1 COHHDKBOPDVULP-UHFFFAOYSA-N 0.000 description 1
- FREHTPKNPMUSMK-UHFFFAOYSA-N N#Cc1cc(C(CC2)=CCC2=O)ccc1 Chemical compound N#Cc1cc(C(CC2)=CCC2=O)ccc1 FREHTPKNPMUSMK-UHFFFAOYSA-N 0.000 description 1
- JXNHEUAANNGFFV-UHFFFAOYSA-N NC(CC1)(CCC1=O)c1ccccc1 Chemical compound NC(CC1)(CCC1=O)c1ccccc1 JXNHEUAANNGFFV-UHFFFAOYSA-N 0.000 description 1
- VZQQLYFMKYCMQZ-UHFFFAOYSA-N O=C(CC1)CC=C1c(cc1)ccc1N=O Chemical compound O=C(CC1)CC=C1c(cc1)ccc1N=O VZQQLYFMKYCMQZ-UHFFFAOYSA-N 0.000 description 1
- LIDGWINURFOALA-UHFFFAOYSA-N O=C(CNC(c(cc1)cc(C(F)(F)F)c1F)=O)NC1CNC1 Chemical compound O=C(CNC(c(cc1)cc(C(F)(F)F)c1F)=O)NC1CNC1 LIDGWINURFOALA-UHFFFAOYSA-N 0.000 description 1
- GRIUVLWWKAQKDF-UHFFFAOYSA-N O=C(CNC(c1cc(C(F)(F)F)ccc1)=O)NC(C1)CN1C(CC1)CCC1c1ccc(CCN2)c2c1 Chemical compound O=C(CNC(c1cc(C(F)(F)F)ccc1)=O)NC(C1)CN1C(CC1)CCC1c1ccc(CCN2)c2c1 GRIUVLWWKAQKDF-UHFFFAOYSA-N 0.000 description 1
- WEMZPTVFMJNMRK-UHFFFAOYSA-N OC(CC1)(CCC1=O)c(cc1)ccc1Cl Chemical compound OC(CC1)(CCC1=O)c(cc1)ccc1Cl WEMZPTVFMJNMRK-UHFFFAOYSA-N 0.000 description 1
- JAVULHNIYKQECV-UHFFFAOYSA-N OC(CC1)(CCC1=O)c1cccc(O)c1 Chemical compound OC(CC1)(CCC1=O)c1cccc(O)c1 JAVULHNIYKQECV-UHFFFAOYSA-N 0.000 description 1
- CJRVNLPYFHEJPE-UHFFFAOYSA-N OC(CC1)(CCC1N(C1)CC1NC(CNC(c1cc(C(F)(F)F)ccc1)=O)=O)c(cc1)ccc1O Chemical compound OC(CC1)(CCC1N(C1)CC1NC(CNC(c1cc(C(F)(F)F)ccc1)=O)=O)c(cc1)ccc1O CJRVNLPYFHEJPE-UHFFFAOYSA-N 0.000 description 1
- PRNCENABYSAGEY-UHFFFAOYSA-N Oc(cc1)ccc1C(CC1)=CCC1=O Chemical compound Oc(cc1)ccc1C(CC1)=CCC1=O PRNCENABYSAGEY-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C07D405/08—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing alicyclic rings
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17030709P | 2009-04-17 | 2009-04-17 | |
| US61/170307 | 2009-04-17 | ||
| US61/170,307 | 2009-04-17 | ||
| PCT/US2010/031265 WO2010121046A1 (en) | 2009-04-17 | 2010-04-15 | 4-azetidinyl-1-phenyl-cyclohexane antagonists of ccr2 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102459227A CN102459227A (zh) | 2012-05-16 |
| CN102459227B true CN102459227B (zh) | 2014-08-20 |
Family
ID=42167720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201080027641.6A Expired - Fee Related CN102459227B (zh) | 2009-04-17 | 2010-04-15 | Ccr2的4-氮杂环丁烷基-1-苯基-环己烷拮抗剂 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20100267689A1 (https=) |
| EP (1) | EP2419419B1 (https=) |
| JP (1) | JP5675773B2 (https=) |
| KR (1) | KR20120006544A (https=) |
| CN (1) | CN102459227B (https=) |
| AR (1) | AR076328A1 (https=) |
| AU (1) | AU2010236346B2 (https=) |
| BR (1) | BRPI1016189A2 (https=) |
| CA (1) | CA2758934A1 (https=) |
| ES (1) | ES2528625T3 (https=) |
| MX (1) | MX2011010964A (https=) |
| NZ (1) | NZ595432A (https=) |
| TW (1) | TW201102377A (https=) |
| WO (1) | WO2010121046A1 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010068663A1 (en) * | 2008-12-10 | 2010-06-17 | Janssen Pharmaceutica Nv | 4-azetidinyl-1-heteroaryl-cyclohexanol antagonists of ccr2 |
| MX2011010919A (es) * | 2009-04-16 | 2011-11-02 | Janssen Pharmaceutica Nv | Antagonistas del receptor 2 de citocina quimioatrayente de 4-azetidinil-1-heteroaril-ciclohexano. |
| WO2010121036A1 (en) | 2009-04-17 | 2010-10-21 | Janssen Pharmaceutica Nv | 4-azetidinyl-1-heteroatom linked-cyclohexane antagonists of ccr2 |
| CN102459227B (zh) | 2009-04-17 | 2014-08-20 | 詹森药业有限公司 | Ccr2的4-氮杂环丁烷基-1-苯基-环己烷拮抗剂 |
| TW201211027A (en) * | 2010-06-09 | 2012-03-16 | Janssen Pharmaceutica Nv | Cyclohexyl-azetidinyl antagonists of CCR2 |
| TW201204717A (en) | 2010-06-17 | 2012-02-01 | Janssen Pharmaceutica Nv | Cyclohexyl-azetidinyl antagonists of CCR2 |
| CA2852160A1 (en) | 2011-10-28 | 2013-05-02 | Galderma Research & Development | New leukocyte infiltrate markers for rosacea and uses thereof |
| AU2012338581B2 (en) | 2011-11-18 | 2016-12-08 | Nxera Pharma Uk Limited | Muscarinic M1 receptor agonists |
| DK2785710T3 (en) * | 2011-12-01 | 2017-12-04 | Chemocentryx Inc | SUBSTITUTED BENZIMIDAZOLES AND BENZOPYRAZOLES AS CCR (4) - ANTAGONISTS |
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- 2010-04-15 NZ NZ595432A patent/NZ595432A/en not_active IP Right Cessation
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| US20120040960A1 (en) | 2012-02-16 |
| CA2758934A1 (en) | 2010-10-21 |
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| EP2419419A1 (en) | 2012-02-22 |
| US20100267689A1 (en) | 2010-10-21 |
| MX2011010964A (es) | 2011-11-02 |
| EP2419419B1 (en) | 2014-12-03 |
| KR20120006544A (ko) | 2012-01-18 |
| TW201102377A (en) | 2011-01-16 |
| US8513229B2 (en) | 2013-08-20 |
| ES2528625T3 (es) | 2015-02-11 |
| CN102459227A (zh) | 2012-05-16 |
| JP2012524111A (ja) | 2012-10-11 |
| JP5675773B2 (ja) | 2015-02-25 |
| NZ595432A (en) | 2013-12-20 |
| AU2010236346B2 (en) | 2015-01-22 |
| BRPI1016189A2 (pt) | 2016-04-19 |
| AU2010236346A1 (en) | 2011-11-03 |
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