KR20110132938A - 라말린을 함유하는 염증질환 또는 면역질환의 예방 또는 치료용 약학 조성물 - Google Patents
라말린을 함유하는 염증질환 또는 면역질환의 예방 또는 치료용 약학 조성물 Download PDFInfo
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- KR20110132938A KR20110132938A KR1020100052551A KR20100052551A KR20110132938A KR 20110132938 A KR20110132938 A KR 20110132938A KR 1020100052551 A KR1020100052551 A KR 1020100052551A KR 20100052551 A KR20100052551 A KR 20100052551A KR 20110132938 A KR20110132938 A KR 20110132938A
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- ramalin
- inflammatory
- disease
- pharmaceutical composition
- diseases
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Abstract
본 발명의 라말린은 천연물 유래의 물질로 독성 및 부작용이 없으며, iNOS(산화질소생성효소)의 발현을 전사단계에서 억제하여 염증 반응의 핵심 매개물질인 NO(산화질소)의 생성을 현저히 억제하고, 염증매개전구물질인 NF-κB의 활성화를 억제하고, p38 MAPK, ERK1/2 및 JNK 신호전달 경로를 억제하고, LPS 수용체인 TLR4의 발현도 억제한 결과 나타나는 탁월한 항염증 효과를 가지므로, 이를 함유하는 조성물은 염증질환 또는 면역질환들을 근본적으로 치료하고 예방할 뿐만 아니라 증상을 완화 및 개선시키는데 유용하게 사용될 수 있다.
Description
도 2는 iNOS mRNA과 대조군으로 GAPDH mRNA 발현량을 RT-PCR 분석으로 알아본 결과이다.
도 3은 iNOS 단백질의 양과 대조군으로 베타액틴 (β-actin) 단백질의 양을 웨스턴 블롯(Western blot) 분석으로 알아본 결과이다.
도 4는 LPS 처리 후, 24시간 동안 표면 발현되는 TLR4의 양을 측정한 결과이다.
도 5는 TLR4 mRNA과 대조군으로 GAPDH mRNA 발현량을 RT-PCR 분석으로 알아본 결과이다.
도 6은 TLR4 단백질의 양과 대조군으로 베타액틴 (β-actin) 단백질의 양을 웨스턴 블롯(Western blot) 분석으로 알아본 결과이다.
도 7은 RAW 264.7 세포들을 pGL3-NF-κB-Luc reporter plasmid와 pCMV-β-gal로 형질 전환시킨 후, 이를 LPS 처리(4시간) 한 다음 상대적인 루시페라아제 값을 측정한 결과이다.
도 8은 NF-κB의 translocation을 분석하기 위해 p65 핵단백질의 양을 측정한 웨스턴 블롯 분석 결과이다.
도 9는 라말린 10ug/ml를 2시간 동안 전처리 하거나, 하지 않고 LPS ug/ml를 표시된 시간만큼 처리한 후 안티 IκBα 항체로 웨스턴 블롯 분석한 결과이다.
도 10은 LPS 자극 받은 대식세포 (macrophages)에서 p-p38, p-JNK, p-ERK 활성화에 대한 라말린의 효과를 나타내는 결과로, 한 시간동안 라말린을 전처리한 후, LPS를 20분 동안 처리한 후, 전체 세포 용해물을 웨스턴 블롯으로 분석한 결과이다.
도 11은 카라기난(또는 캐라지난; carrageenan)에 의해 유도된 쥐의 발 부종 크기 결과로, 부형제를 투여한 대조군과 인도메타신(Indomethacin, SigmaI-7378)을 투여한 양성 대조군과 비교하였을 때 라말린 투여군(100mg/kg)은 6시간 후 50%정도의 항염증 효과를 나타낸다.
Claims (9)
- 제1항에 있어서, 상기 염증질환 또는 면역질환은 아토피피부염, 관절염, 요도염, 방광염, 동맥경화증, 알러지 질환, 비염, 천식, 급성통증, 만성통증, 치주염, 치은염, 염증성 장질환, 통풍, 심근경색, 울혈성 심부전, 고혈압, 협심증, 위궤양, 뇌경색, 다운증후군, 다발성 경화증, 비만, 당뇨, 치매, 우울증, 정신분열증, 결핵, 수면장애, 패혈증, 화상, 췌장염, 파킨슨병, 뇌졸중, 발작에 의한 뇌손상 또는 자가면역질환인 것을 특징으로 하는 예방 또는 치료용 약학 조성물.
- 제1항에 있어서, 상기 조성물은 약학 조성물의 제조에 통상적으로 사용되는 적절한 담체, 부형제 또는 희석제를 추가로 포함하는 것을 특징으로 하는 예방 또는 치료용 약학 조성물.
- 제1항에 있어서, 상기 조성물은 항히스타민제, 소염진통제, 항암제 및 항생제로 이루어진 군에서 선택된 하나 이상의 약제와 함께 제제화하거나 병용하여 사용하는 것을 특징으로 하는 예방 또는 치료용 약학 조성물.
- 제5항에 있어서, 상기 염증질환 또는 면역질환은 아토피피부염, 관절염, 요도염, 방광염, 동맥경화증, 알러지 질환, 비염, 천식, 급성통증, 만성통증, 치주염, 치은염, 염증성 장질환, 통풍, 심근경색, 울혈성 심부전, 고혈압, 협심증, 위궤양, 뇌경색, 다운증후군, 다발성 경화증, 비만, 당뇨, 치매, 우울증, 정신분열증, 결핵, 수면장애, 패혈증, 화상, 췌장염, 파킨슨병, 뇌졸중, 발작에 의한 뇌손상 또는 자가면역질환인 것을 특징으로 하는 예방 또는 치료용 약학 조성물.
- 제7항에 있어서, 상기 기능성 화장품은 염증질환 개선용인 것을 특징으로 하는 기능성 화장품.
- 제8항에 있어서, 상기 염증질환은 아토피 피부염증 또는 화상염증인 것을 특징으로 하는 기능성 화장품.
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
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KR1020100052551A KR101290745B1 (ko) | 2010-06-03 | 2010-06-03 | 라말린을 함유하는 염증질환 또는 면역질환의 예방 또는 치료용 약학 조성물 |
EP11790029.0A EP2578214A4 (en) | 2010-06-03 | 2011-06-02 | PHARMACEUTICAL COMPOSITION WITH RAMALIN FOR THE PREVENTION OR TREATMENT OF INFLAMMATORY OR IMMUNE DISEASES |
JP2013513112A JP2013534517A (ja) | 2010-06-03 | 2011-06-02 | ラマリンを含有する炎症疾患または免疫疾患の予防または治療用医薬組成物 |
CN2011800328082A CN103140222A (zh) | 2010-06-03 | 2011-06-02 | 用于预防和治疗炎性疾病或免疫疾病的含树花素的药物组合物 |
US13/701,113 US20130116324A1 (en) | 2010-06-03 | 2011-06-02 | Pharmaceutical composition for the prevention or treatment of inflammatory diseases or immune diseases containing ramalin |
PCT/KR2011/004049 WO2011152671A2 (ko) | 2010-06-03 | 2011-06-02 | 라말린을 함유하는 염증질환 또는 면역질환의 예방 또는 치료용 약학 조성물 |
US14/261,551 US9539227B2 (en) | 2008-11-10 | 2014-04-25 | Pharmaceutical composition for the prevention or treatment of inflammatory diseases or immune diseases containing ramalin |
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KR1020100052551A KR101290745B1 (ko) | 2010-06-03 | 2010-06-03 | 라말린을 함유하는 염증질환 또는 면역질환의 예방 또는 치료용 약학 조성물 |
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EP (1) | EP2578214A4 (ko) |
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WO2013129714A1 (ko) * | 2012-02-28 | 2013-09-06 | 한국해양연구원 | 라말린을 함유하는 간섬유화 및 간경화의 예방 또는 치료용 약학 조성물 |
US8865934B2 (en) | 2010-07-14 | 2014-10-21 | Korea Ocean Research And Development Institute | Method for preparing ramalin |
US9284266B2 (en) | 2012-01-19 | 2016-03-15 | Korea Institute Of Ocean Science And Technology | Method for synthesizing ramalin and ramalin precursor by using glutamic acid derivative and hydroxy aniline or hydroxy aniline having protected hydroxy group |
WO2016064009A1 (ko) * | 2014-10-24 | 2016-04-28 | 한국해양과학기술원 | 라말린을 함유하는 퇴행성 뇌질환의 예방 또는 치료용 조성물 |
KR20160049095A (ko) * | 2014-10-24 | 2016-05-09 | 한국해양과학기술원 | 라말린을 함유하는 퇴행성 뇌질환의 예방 또는 치료용 조성물 |
KR101642291B1 (ko) * | 2015-01-19 | 2016-07-26 | 한국해양과학기술원 | 라말린을 유효성분으로 함유하는 암의 예방 또는 치료용 조성물 |
WO2019059470A1 (ko) * | 2017-09-21 | 2019-03-28 | 한국해양과학기술원 | 라말린을 유효성분으로 함유하는 대장암 예방 또는 치료용 조성물 |
WO2022102988A1 (ko) * | 2020-11-11 | 2022-05-19 | 한국해양과학기술원 | 남극 지의류 아만디네아 추출물의 제조방법 및 아만디네아 추출물을 포함하는 조성물 |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
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KR101025612B1 (ko) * | 2008-11-10 | 2011-03-30 | 한국해양연구원 | 신규 화합물인 Ramalin 및 그 용도 |
KR101290745B1 (ko) | 2010-06-03 | 2013-07-29 | 한국해양과학기술원 | 라말린을 함유하는 염증질환 또는 면역질환의 예방 또는 치료용 약학 조성물 |
KR101429242B1 (ko) * | 2012-03-19 | 2014-08-12 | 한국해양과학기술원 | 다공성 매트릭스를 이용한 라말린의 안정화 방법 및 안정화된 라말린 용액 |
KR102393317B1 (ko) * | 2017-10-31 | 2022-05-03 | 광주과학기술원 | 글루탐산 유도체 및 이를 포함하는 조성물 |
MX2020009999A (es) * | 2018-03-29 | 2020-11-06 | S I S Shulov Innovative Science Ltd | Composiciones farmacéuticas para inhibir citocinas inflamatorias. |
CN114480625A (zh) * | 2022-03-04 | 2022-05-13 | 浙江省立同德医院 | Mapk信号通路抑制在慢性骨髓炎改善、诊断和治疗中的应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR980008216A (ko) * | 1996-07-01 | 1998-04-30 | 성재갑 | 지의류 추출물을 함유하는 세안제 조성물 |
US5789395A (en) | 1996-08-30 | 1998-08-04 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
AU3511500A (en) | 1999-03-05 | 2000-09-21 | Trustees Of University Technology Corporation, The | Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions |
JP2005082531A (ja) * | 2003-09-09 | 2005-03-31 | Maruzen Pharmaceut Co Ltd | 抗炎症剤、並びに化粧料及び飲食物 |
US20060105989A1 (en) * | 2004-11-18 | 2006-05-18 | Kinya Takagaki | Food for improving arthritis |
KR20080111021A (ko) | 2006-03-29 | 2008-12-22 | 바스프 에스이 | 철 대사 장애의 치료를 위한 스트로빌루린의 용도 |
AP2011005681A0 (en) | 2008-10-02 | 2011-04-30 | George Zabrecky | Methods and formulations for treating chronic liver disease. |
KR101025612B1 (ko) * | 2008-11-10 | 2011-03-30 | 한국해양연구원 | 신규 화합물인 Ramalin 및 그 용도 |
KR101290745B1 (ko) | 2010-06-03 | 2013-07-29 | 한국해양과학기술원 | 라말린을 함유하는 염증질환 또는 면역질환의 예방 또는 치료용 약학 조성물 |
KR101182334B1 (ko) | 2010-07-14 | 2012-09-20 | 한국해양연구원 | 라말린의 합성방법 |
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2010
- 2010-06-03 KR KR1020100052551A patent/KR101290745B1/ko active IP Right Grant
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2011
- 2011-06-02 EP EP11790029.0A patent/EP2578214A4/en not_active Withdrawn
- 2011-06-02 WO PCT/KR2011/004049 patent/WO2011152671A2/ko active Application Filing
- 2011-06-02 CN CN2011800328082A patent/CN103140222A/zh active Pending
- 2011-06-02 JP JP2013513112A patent/JP2013534517A/ja active Pending
- 2011-06-02 US US13/701,113 patent/US20130116324A1/en not_active Abandoned
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2014
- 2014-04-25 US US14/261,551 patent/US9539227B2/en active Active
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US8865934B2 (en) | 2010-07-14 | 2014-10-21 | Korea Ocean Research And Development Institute | Method for preparing ramalin |
US9284266B2 (en) | 2012-01-19 | 2016-03-15 | Korea Institute Of Ocean Science And Technology | Method for synthesizing ramalin and ramalin precursor by using glutamic acid derivative and hydroxy aniline or hydroxy aniline having protected hydroxy group |
CN104244937B (zh) * | 2012-02-28 | 2016-08-24 | 韩国海洋科学技术院 | 含ramalin的用于预防或治疗肝纤维化和肝硬化的药物组合物 |
CN104244937A (zh) * | 2012-02-28 | 2014-12-24 | 韩国海洋科学技术院 | 含ramalin的用于预防或治疗肝纤维化和肝硬化的药物组合物 |
KR101326256B1 (ko) * | 2012-02-28 | 2013-11-11 | 한국해양과학기술원 | 라말린을 함유하는 간섬유화 및 간경화의 예방 또는 치료용 약학 조성물 |
US9364452B2 (en) | 2012-02-28 | 2016-06-14 | Korea Institute Of Ocean Science And Technology | Pharmaceutical composition for preventing or treating hepatic fibrosis and cirrhosis containing ramalin |
WO2013129714A1 (ko) * | 2012-02-28 | 2013-09-06 | 한국해양연구원 | 라말린을 함유하는 간섬유화 및 간경화의 예방 또는 치료용 약학 조성물 |
WO2016064009A1 (ko) * | 2014-10-24 | 2016-04-28 | 한국해양과학기술원 | 라말린을 함유하는 퇴행성 뇌질환의 예방 또는 치료용 조성물 |
KR20160049095A (ko) * | 2014-10-24 | 2016-05-09 | 한국해양과학기술원 | 라말린을 함유하는 퇴행성 뇌질환의 예방 또는 치료용 조성물 |
CN107205973A (zh) * | 2014-10-24 | 2017-09-26 | 韩国海洋研究院 | 用于预防或治疗神经变性疾病的含有Ramalin的组合物 |
CN113456623A (zh) * | 2014-10-24 | 2021-10-01 | 韩国海洋研究院 | 用于预防或治疗神经变性疾病的含有Ramalin的组合物 |
KR101642291B1 (ko) * | 2015-01-19 | 2016-07-26 | 한국해양과학기술원 | 라말린을 유효성분으로 함유하는 암의 예방 또는 치료용 조성물 |
WO2019059470A1 (ko) * | 2017-09-21 | 2019-03-28 | 한국해양과학기술원 | 라말린을 유효성분으로 함유하는 대장암 예방 또는 치료용 조성물 |
WO2022102988A1 (ko) * | 2020-11-11 | 2022-05-19 | 한국해양과학기술원 | 남극 지의류 아만디네아 추출물의 제조방법 및 아만디네아 추출물을 포함하는 조성물 |
Also Published As
Publication number | Publication date |
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EP2578214A2 (en) | 2013-04-10 |
EP2578214A4 (en) | 2013-11-20 |
WO2011152671A2 (ko) | 2011-12-08 |
US20130116324A1 (en) | 2013-05-09 |
CN103140222A (zh) | 2013-06-05 |
US20140235719A1 (en) | 2014-08-21 |
WO2011152671A3 (ko) | 2012-03-29 |
JP2013534517A (ja) | 2013-09-05 |
KR101290745B1 (ko) | 2013-07-29 |
US9539227B2 (en) | 2017-01-10 |
WO2011152671A9 (ko) | 2012-05-24 |
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