KR20110116156A - Method for the production of a stack of medicament pouches used for storing and supplying medicament wafers, medicament pouch template for producing said stack, and use of the medicament pouch template - Google Patents

Abstract

A method for safely manufacturing a stack 100 of medical pockets 4, 4 ′, 4 ″ containing a medical wafer 2 is disclosed, wherein each of the pockets has several adjacent marking portions on the marking edge 17. There is a marking (3) in one of the 18. In the method, the medicine pockets (4, 4 ', 4 ") in one or more stacks, where the marking (3) is located in the continuous marking portion (18). Medical pockets 4, 4 ′, 4 ″ with markings 3 located at the first end of the marking edge 17 are arranged at the second end of the marking edge 17. The medication pockets 4, 4 ′, 4 ″ are stacked up one by one so that the medication pockets 4, 4 ′, 4 ″ are arranged behind the medication pockets 4, 4 ′, 4 ″ with the marking 3 located thereon so that one or more stacks of medication pockets 100 Is formed.

Description

METHOD FOR THE PRODUCTION OF A STACK OF MEDICAMENT POUCHES USED FOR STORING AND SUPPLYING A method of making a stack of medical pockets used to store and provide a medical wafer MEDICAMENT WAFERS, MEDICAMENT POUCH TEMPLATE FOR PRODUCING SAID STACK, AND USE OF THE MEDICAMENT POUCH TEMPLATE}

Explanation

FIELD OF THE INVENTION The present invention relates to a method of manufacturing a stack of medical pockets for storing and providing a medical wafer, comprising by the use of a mold of the medical pocket, the manufacture of the stack, and the storage of the medical wafer. And for the manufacture of a device for providing. The medical wafer contains the medicines in a stacked form. In particular, the pharmaceutical wafer may contain hormonal medications, in particular medications for contraception or hormone replacement therapy.

Prior art:

A medical wafer is a device in the form of a sheet containing a pharmaceutical active material contained within an active material carrier. The active material in the wafer can be administered, for example, transmucosally, i.e., through the mucous membrane of the mouth, in that the wafer is placed on or under the tongue, wherein the active material carrier dissolves to release the active material. Can be. Wafers are provided in the form of wafers placed in pockets in the sheet to protect them from mechanical and other environmental influences, such as moisture. According to DE 101 59 746 B4, these pockets may comprise one or more carrier sheets and one or more top sheets, wherein at least the larger surface area of the sheet has two parallel side edges, the sheet- or web An analogous material (wafer) is put in a gas- and moisture-blocking manner between the carrier sheet and the top sheet. An apparatus for storage and provision of a medical wafer may contain pockets in stacked sheets therein. Of course, the medical wafer may be formed differently in that it does not necessarily need to comprise a sheet of larger surface area and a sheet of smaller surface area and for example comprises sheets of the same size. In order to manufacture the device according to DE 101 59 746 B4, the described pockets in the sheet containing the medical wafer are easily combined into a stack and introduced into the device. The apparatus described in the above document for storing and providing a wafer comprises a housing that is partitioned one or more times, with the side edges of the stacked pockets in the sheet lying against the side inner surface of the housing, while the associated top sheet The edge of the carrier sheet protruding beyond the edge of lie against the front inner surface. The stacked pockets in the seat are pressed against the upper inner surface of the housing by a spring. In the front upper area of the housing there are two slits for separate delivery of the carrier sheet and the top sheet, and the wafer can be provided with the carrier sheet or with the top sheet. After removal of the pockets in the seat, the spring is tasked to keep the remaining pockets in the seat together adjacent to the slit and position them for further removal. Between the slits a separation tool for separating the carrier sheet from the top sheet is arranged, for which the topmost carrier sheet lies with its area lying in front of the front edge of the top sheet. A carrying element that can rotate about an axis of rotation serves to carry the medication pocket from the housing.

Such a device with a medication pocket that can be removed one by one can be used by a user using the medication pocket removed to take the medication wafer, on the other hand, whether the wafer intended to be taken in a particular period of time has already been taken or should still be taken. The disadvantage is that there is no possibility to monitor. Thus, two wafers can be easily taken instead of one, or the user completely forgets to take the wafer.

On the other hand, with such a closure device it is also not possible to know how many wafers the user has already removed or how long the prescription process has to continue. In addition, one particular disadvantage of such devices is that because of the closed type design, the user is also unable to know whether the device actually contains all the medical pockets required for treatment. The opening of this compact device was not intended and would destroy it.

In order to take hormonal medications, as well as other medications, it is important to take the medication as a prescribed course of treatment of the patient, for example three times a day or once a day, where such therapies It is prescribed by a doctor. However, most medications are taken only for a limited period of time, for example, until the condition to be treated is fully cured. However, there are also medications that must be taken over a very long time. In this case, it may happen that the medication is not taken or at the prescribed time. The success of the therapy is then often at risk. Therefore, many attempts have been made to monitor medication taking, and self-monitoring by the patients themselves has been particularly important.

The integrity of the device containing the medical wafer is a basic requirement for the success of the medical treatment. This is especially true when using medical wafers for contraception and hormone replacement therapy. For this reason, considerable effort is spent on quality assurance when manufacturing devices for time-dependent drug administration. In addition, of course, the user of such a device is also interested in the possibility of monitoring.

Regarding the monitoring of the time and frequency of taking units of active substance in the form of tablets, coated tablets, etc., known as medicinal blisters, ie in pockets stamped in the first sheet Apparatuses for storing tablets, coated tablets, and the like, which contain tablets, coated tablets, and the like, which are connected to a second sheet to which the sheet can be torn and the pocket is sealed, are disclosed in the prior art. If the dosage of the tablet depends on the particular time of day, an indicator, for example the day of the week, may be provided on the second sheet.

For example, in EP 0 166 763 B1, blisters with tablet pockets arranged in a row are provided. In the manufacture of such blisters, the pockets are assigned to the dates of one or more calendar months in a clear manner, with further successive integer representations visualized by each pocket having a unique calendar day of the calendar month. Arranged in a clear relationship near the pockets in such a way that it can be identified, and successive integer indicators are arranged based on the torn area in the second sheet in such a way that it can be seen from the back of the second sheet. Each zone can be visually identified by the only calendar day in the calendar month. This allows each pocket to be visually identified from both the front and back side by unique role. As a result, taking tablets daily and observing user compliance may be easier.

In addition, in EP 0 511 726 B1, a blister pack of a predetermined surface area, in which a plurality of tablets arranged in a selected array are located, a container containing the blister pack, and an array of tablets in the blister pack can be aligned. A technique is provided for a facility for receiving tablets in an array, including a daily calendar, wherein the calendar may be shifted to place the selected departure date with the first tablet in the array of tablets, An indication is provided on the container and the blister pack has a positioning notch near the edge and adjacent the first tablet so that the first tablet to be taken is indicated.

In addition, DE 10 2005 032 015 A1 discloses a case for receiving a blister pack having a first half and a second half following the first half. The first half of the case is formed as a pocket for receiving the blister pack and has an outer portion and an inner viewing portion, as well as a first hole in the viewing portion and a second hole in the outer portion, wherein the first hole is precisely Is aligned with the second aperture, at least where the container for tablets in the blister pack is located after being received in the pocket. The second half of the case has a compartment for accommodating the display means for displaying the day of the week and a window for displaying the day of the week within the interior viewing area of the second half of the case in the area of this compartment, which window of the blister pack accommodated in the pocket. Arranged in such a way that they are assigned to the columns of the vessel.

However, these embodiments of devices for storage and provision of a medicine unit relate to tablets in blister packs, the manufacturing process of which is fundamentally different from the manufacturing process for devices with a medical wafer in a medicine pocket.

A further example of providing the patient with assistance to ensure that the medication is taken in a controlled process despite routine distractions to the patient is, for example, a medication in which the removal of individual tablets is automatically registered. It is a device for receiving a pack. Various proposals for this are given in DE 198 50 890 A1 (dispensing device for medicaments, ie tablets, etc.), DE 197 39 438 A1 and DE 195 16 076 A1 (pack for solid form medicinal samples, ie tablets, etc.), DE 198 52 602 A1 (apparatus and method for reminding medications, ie tablets, etc. to be taken on time), DE 102 13 547 C1 (blister pack facility), DE 41 34 237 C1 (removal of pills from blister packs) Device for registration), EP 0 191 168 A2 (device for urging to store and take medicine, ie tablets), DE 198 36 100 A1 (device for storing container of medicine, ie container for tablets, etc.), DE 102 17 929 A1 (device for tablet dispensing), US 2004/005 0746 A1 (pill holder and remote device), WO 01/54646 A2 (pill dispenser with alarm function) and DE 10 2005 048 515 A1 (a solid medicinal potion, ie a dispenser for tablets and the like, and uses thereof).

However, no proposal has been made for the dosing monitoring of the medical wafer to ensure that the medical wafer is reliably administered. Dispensers for confectionery or medicaments in the form of wafers are known, for example, from DE 101 59746 B4. However, such a device has the disadvantage that no monitoring possibility is provided to the user as to whether the prescribed course of administration has been followed for a certain period of time. Thus, two wafers may be easily taken instead of one, or the user may completely forget to take the wafer. In particular, it is particularly important that the pill is taken over a very long period of time without being interrupted in taking the pill. In such cases, the user should be careful to take one dose of medication daily without exception. Missing a dose will be a significant risk, as will taking two medications on the same day. For these indications, there is a means to ensure that medicinal wafers are taken reliably as long as the medical wafer is considered, since in a stressful situation there is quite a possibility that the user will forget to take a dose of medication for the prescribed period of time. Is especially problematic. Furthermore, it is of course also required that such means be provided by a flawless and inexpensive manufacturing process.

For this reason, the first goal is to prepare for the user a medical pocket containing a medical wafer, in the order provided and at the prescribed intervals, and depending on the time the wafer should be taken, by removing the wafer from the device and taking it. It is to find a means to be. For this purpose, the device should be suitable to enable the user to monitor the dose of prescribed medical wafer over a certain period of time. In addition, devices for storage and provision of medical wafers are intended to be suitable for daily use and to have the required mechanical stability. Medical wafers are also intended to be reliably stored.

An additional goal is that such dosage formulations can be produced easily, simply and consequently at a low cost by a substantially defect-free manufacturing process to ensure that dosage formulations are reliably taken without errors in the wafer. To do it. Low cost preparation of the dosage form also requires that many such dosage forms can be prepared in a short time.

It is therefore a further object of the present invention to devise a method for manufacturing a stack in such a way that a simple check on the integrity of the stack with respect to the number of medicinal pockets is already possible during the manufacturing process. In particular, it is intended to enable flawless stacking so that the stack does not contain too few or too many medical pockets. In this way, it is intended to reduce the cost incurred by rejects and the cost for final inspection or quality assurance of the manufactured stack.

It is a further object of the present invention to provide a mold of a medicine pocket and a method of manufacturing a stack of medicine pockets which serve to store and provide a medicine wafer from the medicine pocket mold, using which the medicine has already been removed by the user. A stack can be created that allows the wafer to be monitored during use.

Summary of the Invention:

These and other objectives are provided by the manufacturing method claim for a stack of medical pockets that serve to store and provide a medical wafer, by the mold claim of a medical pocket for manufacturing such a stack of medical pockets, and also such medical pockets. It is achieved by the claim of the use of a mold of medical pockets for the manufacture of a stack of medicaments. Preferred embodiments of the invention are detailed by the subclaims.

The method according to the invention serves to manufacture a stack of medicinal pockets which serve to store and provide medicinal wafers, wherein each medicinal pocket has a plurality of arranged next to each other at the marking edge on the marking edge. There is a marking individually in one of the marking parts.

Typically, medical pockets for medical wafers include a base or bottom sheet and a top sheet. By means of a strip-shaped connection, preferably along the side edges of the top sheet, the top sheet can be connected to the base or bottom sheet, for example adhesively joined or welded, or vice versa. have. In addition, in a particularly preferred embodiment, in each case there may be each projecting tab which is not connected to each other in the base or bottom sheet and the top sheet on one or more side edges. Since the two sheets can be easily grasped, this makes it easier to pull the medical pocket apart for the removal of the wafer contained in the pocket, and consequently to open it. In the region formed by the connection, the medical wafer is enclosed between the base or bottom sheet and the top sheet, preferably in an air- and moisture-blocking manner. The pockets in the sheets may have a small rise only in the area of the wafer due to the way they are formed or as a result of the latter.

The dispenser device manufactured by the method according to the invention for the storage and provision of a medical wafer contains medical pockets with the medical wafer in the form of a stack (of pockets). In order to allow a user to monitor whether a medical wafer has already been taken or should still be taken within a certain period of time, a time indicator may be arranged in the device in particular parallel to the edges of the medical pockets. In addition, the medication pockets with markings provided on the medication pockets which are connected to each other in the stack are respectively aligned with the time stamps which are next to each other and, where appropriate, located at the first end of the marking edge in the stack. A marking is provided on each medication pocket in such a way as to follow the medication pocket with the marking located at the second end. This example mentioned later applies in all cases where a large number of medical pockets are placed in the stack which is larger than the number of marking portions on each medical pocket, so that the sequence of markings following each other in the marking portion is repeated in the stack. Thus, although the markings are followed by medical pockets which run into each other in the stack, if the medical pocket has markings in the last marking part, the subsequent medical pockets in the stack have markings in the first marking part again. Subsequent medication pockets in the stack then have markings in the marking portions that follow each other.

For reliable self-monitoring by the user, according to the present invention, once the stack is accommodated in the dispenser device for the storage and provision of the wafer, the markings arranged on the marking edge are aligned with the time indication. This allows the user to establish whether the wafer has been removed within a certain period of time.

However, such stacks must be manufactured without defects. This means that if a single medication pocket is lost from the stack, or if a dual medication pocket is in the stack, and consequently the marking in a particular marking portion of a series of medication pockets in the stack is lost or doubled, the user will be deceived and may be taking the medication incorrectly. This is because the user may forget to take the wafer or take two wafers instead of one within the prescribed period of time. Thus, a medicament with a marking in which the markings of the medicinal pockets which are contiguous in the stack are likewise within the marking portions which are contiguous with each other or, where appropriate, a medicinal pocket with a marking located at the first end of the marking edge is located at the second end of the marking edge. The method of manufacturing the stack must proceed without defects in such a way that a stack is prepared in which the medical pockets with markings are stacked up one by one so as to follow the pocket.

In addition, it should be assured that the stack can be manufactured at high manufacturing efficiency, ie, especially at high cycle rates.

For this reason, the following production method according to the invention for the stack is provided to achieve the stated goal:

Markings in which one or more stacks of medical pockets with markings are located next to each other in the marking portions which are connected to each other and, where appropriate, with a medical pocket with markings located at the first end of the marking edge Stacking the medication pockets one by one to form one or more stacks of pockets, so as to follow the medication pockets therewith.

In this case, and in other cases of the present application, if stacking the medicine pockets one by one or stacking of the medicine pockets is mentioned, this is intended to mean placing the medicine pockets one by one, ie stack, for example A medication pocket that is stacked on the stack is placed on the stack.

The stack prepared by the method according to the invention can be used particularly for the storage and provision of medical wafers that play a role in contraception or hormone replacement therapy.

A template of medicine pockets is also provided to produce a stack of medicine pockets that serve to store and provide a medical wafer from which the medicine pocket can be formed by isolation.

In each case, with the marking on the marking edge of the medication pocket, it is ensured that the user can in each case monitor whether or not the wafer has already been taken within the specific period prescribed. This occurs by checking whether the marking of the medication pocket on the top is aligned with the time mark zone corresponding to that period.

Detailed description of the invention

In a first preferred embodiment of the invention, the preparation method comprises the following steps:

a) in the first part-stack in each of the marking parts leading to each other so that the medicine pockets in which the markings are located are connected to one another and, where appropriate, the medicine pockets with markings located at the first end of the marking edge are marked. Stacking the medication pockets one by one in a first manufacturing device to form one or more first part-stacks, followed by a medication pocket with a marking located at the second end of the edge;

b) in the respective part-stacks formed in this way so that the medicine pockets in which the markings are located are connected to one another in the marking parts which are connected to each other and, where appropriate, the medical pockets with markings located at the first end of the marking edges. Stacking additional medication pockets on the one or more first part-stacks in a second manufacturing device, followed by a medication pocket with a marking located at the second end of the;

c) where appropriate, repeating process step b) one or more times by stacking additional medication pockets in the additional manufacturing apparatus on one or more part-stacks respectively generated in the second or additional manufacturing apparatus, and finally in one or more of the pharmaceutical pockets Forming a stack.

In this variant of the method, the fact that the one or more first part-stacks are first created in the first manufacturing device and the additional medicine pockets are stacked on the one or more first part-stacks in the additional manufacturing device, specifically speaking, the additional medicine When stacking pockets on one or more first part-stacks in an additional manufacturing apparatus, it is advantageously possible, by the fact that at the same time one or more next first part-stacks are preferably produced in the first manufacturing apparatus, This means that it is achieved. This allows the part-stacks to be created at the same time. This applies equally if one or more completed stacks of pockets have not yet been manufactured by stacking the medical pockets on one or more first part-stacks in a second manufacturing device, but instead first one or more second part-stacks Only need to be created and additional medication pockets to be stacked on this one or more second part-stacks. Specifically, the medical pockets are then stacked on one or more second part-stacks in a third manufacturing device. The one or more third part-stacks or one or more completed stacks of pockets created thereby are likewise preferably created simultaneously with one or more first part-stacks and one or more second part-stacks and the like.

It is also advantageous that after the creation of each part-stack, it can be checked separately whether the part-stack has been manufactured without defects. This makes it possible to reject defective part-stacks from the manufacturing process before completion of the finished stack of pockets. This achieves the effect that additional medical pockets are no longer stacked on the already defective part-stack. On the one hand, this increases manufacturing capacity and on the other hand reduces rejection.

In particular, in a further preferred embodiment of the present invention, a first part-stack is created in the first manufacturing device by stacking the medication pockets one by one, and one or more second and third part-stacks are respectively formed in advance of the additional medication pockets. Stacking on the part-stack is produced in the second and third manufacturing apparatuses, and one or more completed stacks of medication pockets are created in the fourth manufacturing apparatus by stacking additional medication pockets on each third part-stack.

In a further preferred embodiment of the invention, the additional part manufactured in the additional manufacturing device, produced by stacking one or more first part-stacks and additional medicine pockets produced in the first manufacturing device on the one or more first part-stacks. The stack is created simultaneously, ie, further stacking the medicine pockets on the one or more first part-stacks in the additional manufacturing device, coincides with the creation of the one or more first part-stacks in the first manufacturing device, wherein the additional The one or more first part-stacks are, of course, conveyed to the second manufacturing device such that the medicine pockets can be stacked on the first part-stack to form one or more second part-stacks or one or more completed stacks of medicine pockets. Before it must be produced in the first manufacturing apparatus. This is of course also true if additional medical pockets are stacked on one or more second part-stacks in the third manufacturing device so that one or more third part-stacks can be created simultaneously with the one or more first and second part-stacks. The same applies. This order may continue as desired, specifically speaking by generating one or more fourth part-stacks in the fourth manufacturing device or by creating one or more completed stacks of medicine pockets, one or more fifth in the fifth manufacturing device. By creating a part-stack or by creating one or more completed stacks of medication pockets.

In a second variant of the invention, the method comprises the following process steps:

a) a medication pocket with a marking located at the first end of the marking edge so that the medicine pockets in which the marking is located in each of the first and second part-stacks and in the additional part-stack are connected to each other and if appropriate One or more first part-stacks in the first manufacturing device, and in each case one in the additional manufacturing device, stacking the medical pockets one by one up, followed by a medical pocket with markings located at the second end of this marking edge. Forming the above additional part-stack;

b) in the finished portions of each of the finished stacks the medical pockets with the markings located next to each other, and if appropriate, the medical pockets with the markings located at the first ends of the marking edges are connected to the second ends of the marking edges. Stacking one or more first part-stacks and additional part-stacks formed in process step a) up one by one to form a one or more completed stacks of medicine pockets, followed by a medicine pocket with a marking located thereon.

Thus, in this second variant of the invention, the medicine pocket with the marking located at the first end of the marking edge is connected to each other and the medical pockets with the marking located at the first end of the marking edge are connected to each other in the marking portions which are connected to each other in the stack. One or more first part-stacks formed in the first manufacturing device of process step a) and additional part-stacks formed in the additional manufacturing device (second, third) so as to be followed by a medicine pocket with a marking located at the second end of the , Fourth part-stack, etc.) are stacked up one by one to form a stack of pockets.

In a preferred embodiment of this second practice variant of the invention, four part-stacks are first created in each case, and then these four part-stacks are stacked up one by one each so that the finished stack of pockets in each case is Is formed.

In a further preferred embodiment of this second variant of the invention, one or more first part-stacks formed in the first manufacturing device and additional part-stacks produced in the additional manufacturing device are simultaneously produced, ie stacking the medicine pockets one by one respectively Simultaneous formation of one or more first part-stacks, one or more second part-stacks, one or more third part-stacks, one or more fourth part-stacks, and the like.

In this practice variant, one or more part-stacks are first manufactured in each case and then combined by stacking them up one by one with each part-stack (previously manufactured separately), so that one or more finished stacks of medicinal pockets The fact that it also forms in this case causes any defective part-stack to fail from the manufacturing process before the entire stack of pockets is formed. As a result, on the one hand, low-cost manufacturing is possible because the amount of rejects is minimized. On the other hand, the manufacturing process is consequently faster because medicinal pockets that would otherwise have been included in the defective stack can be used to produce a flawless stack.

In a further preferred embodiment of the two variants of the invention, two or more first part-stacks are created simultaneously in each case by stacking the medication pockets one by one, and two or more second part-stacks are created simultaneously Two or more third part-stacks are created at the same time and continue in this way (by stacking each medical pocket on the already-formed part-stack except for the first part-stack in the first implementation variant of the invention). And in a second implementation variant of the invention each case separate stacking of the medication pockets one by one to form a corresponding part-stack, then combining together by stacking the first, second, third part-stacks and the like one by one up. By). For example, stacking medication pockets one by one, in each case six or twelve first part-stacks are created simultaneously. This may occur in a suitable first manufacturing device by parallel transport of medicine pockets. This simultaneously created six or twelve first part-stacks are then transferred to a second manufacturing device, where likewise a six or twelve second part-stacks or a finished stack of six or twelve pockets. It is manufactured at the same time. Or six or twelve first part-stacks are combined with six or twelve second part-stacks in the second manufacturing apparatus in a manner corresponding to the second execution variant. For example, six or twelve second part-stacks in the first variant of the invention are transferred into a third manufacturing device and simultaneously stacking additional medication pockets on six or twelve second part-stacks. By generating here six or twelve third part-stacks or a finished stack of six or twelve pockets, or six or twelve second part-stacks in the second variant of the invention By combining with the third part-stack in the three manufacturing apparatus, this order can be continued as desired.

Since multiple part-stacks are produced simultaneously in the manufacturing apparatus, this procedure results in a very efficient and fast manner of production. However, for both variants of the method, simultaneous stacking means that the medication pockets are stacked up one by one to form each part-stack in synchronism, i.e. it is "equal cycle" or "synchronous". It should not be understood only as being. Rather, it should also be understood that simultaneous stacking means that each part-stack is generated at approximately the same time. A stack of pockets can be manufactured very quickly in this way. However, it is desirable in this case to stack synchronously one by one. For this purpose, after multiple drug pockets are simultaneously supplied to each manufacturing apparatus, these simultaneously supplied drug pockets are synchronously stacked up one by one to form a part-stack.

In a further preferred embodiment of the invention with respect to both variants of the invention, in each case the medicine pockets are stacked up one by one so that a part-stack is produced in the cassette. One or more cassettes are preferably provided for this purpose, and the medical pocket is placed into this cassette and then stacked up one by one. For example, six or twelve cassettes may be provided, for example arranged in rows or carousels.

In addition, such additional manufacturing apparatus, in that the cassettes can be removable, for example, to move the part-stacks created in the cassette to the additional manufacturing apparatus, and the additional part-stack lies on the first part-stack in the cassette. In which each part stack is combined with another part-stack in a manner corresponding to the second implementation variant of the invention.

Alternatively, the cassettes may also be removable for transporting them to the second manufacturing device, in which further medical pockets are stacked on the first part-stack according to the first implementation variant of the invention. For example, the first part-stack may be formed by seven medication pockets. In the second manufacturing device, seven medical pockets can likewise be stacked on the first part-stack. Thereafter, the second part-stack containing 14 medicine pockets can now be transported to the third manufacturing device, where, for example, further seven medicine pockets are stacked on the second part-stack. . Thereafter, the third part-stack containing 21 medicine pockets can now be transported to the fourth manufacturing device, where, for example, further seven medicine pockets are stacked on the third part-stack. . In principle, this process can be carried out in each case with any number of medicine pockets in each manufacturing device and with any number of manufacturing devices. For example, a stack of pockets with 28 medication pockets can be manufactured in this manner.

When a wafer contained in a medical pocket is used for hormone replacement therapy, the stack of pockets typically contains 28 medical pockets. The 28 drug pockets may contain 28 identical drug wafers (for single step formulations), or may contain 24 identical drug wafers and additional 4 drug wafers with placebo or different medications (2-step For contraceptives in the case of formulations), or 21 additional pharmaceutical wafers (as well as for two-stage formulations) with placebo or different medications. In the case of a two-stage formulation, a medication pocket containing a wafer containing a placebo or other medication should be inserted at the beginning or end of the stack of pockets. For this purpose, medicinal pockets containing wafers containing placebo or other medicaments are preferably connected together in a separate manufacturing apparatus, to form a stack at the beginning, or in a separate manufacturing apparatus, in a stacking process. Stacked on the part-stack already created at the end.

In a further embodiment of the invention, the stack of pockets, eg also for use for contraception, may also contain more than 28 different numbers of medical pockets, specifically for example 30 medical pockets. In this case, ten medication pockets may each be added to an existing part-stack at each manufacturing device (or stacked up one by one to create a first part-stack), or seven medication pockets may be Each added (four times), and finally two additional medication pockets may be added in an additional manufacturing device.

In a further embodiment of the present invention, when used for contraception, a wafer may also be used for what is known as an autonomous dosing regimen, wherein the wafer is removed during the first autonomous dosing step lasting at least 24 days, up to 120 days. This is followed by a discontinuation phase that lasts for example four days, followed by the first autonomous dose phase. In this case, the stack of pockets may also include, for example, 28 or 56 or 84 or 112 or 120 medication pockets, or any other number. The form of stacking the medication pockets one by one in accordance with the invention is based on the number of medication pockets each placed in the stack in a corresponding manner in this case.

In a preferred embodiment of the invention, seven marking portions can be located on the marking edge of each medicine pocket. While the marking is provided in one of the marking portions of the medicine pocket, these marking portions may correspond, for example, to the day of the week. In an assembled dispenser device for storing and providing a medical wafer, the marking in the marking portion on the top medicine pocket in the stack is aligned with the specific day of the week indication on the device, eg, "Mo" for Monday, and consequently the user The marking portion may be aligned with a corresponding time mark on the device, for example the day of the week mark, to indicate to the day on which the wafer in this medicine pocket should be taken, ie Monday in this case.

Alternatively, for example, three marking portions corresponding to three times a day (morning, lunch, dinner), or different numbers of marking portions corresponding to the respective requirements for the frequency of taking the drug may also be provided. .

Also, for example, seven medication pockets can be stacked up one in each case to form one or more first part-stacks. In a first implementation variant of the invention, in each case seven additional medication pockets are then stacked on one or more first part-stacks to form a second part-stack, and seven additional medication pockets are one or more seconds. It continues stacking on the part-stack. In a second implementation variant of the invention, in addition to the first part-stack, in each case a second, third part-stack or the like containing seven medical pockets is created. Then, each part-stack is stacked up one by one.

This approach may be particularly advantageous where there are seven marking parts corresponding to seven days of the week in the medicine pocket. In this case, if in each case one wafer is taken per day, the medication pocket in the part-stack is preferably used for taking the wafer for a week.

In a further preferred embodiment of the first variant of the invention, the stack is made in four manufacturing apparatus, with seven medicine pockets stacked in each case for each stack. In a second variant of the invention, four part-stacks are created and then combined together to form a completed stack by stacking each medication pocket one by one. If a wafer is taken once in each case and seven medication pockets in each case are in the part-stack, then 28 wafers taken within 28 days are combined in the stack.

In a further preferred embodiment of the invention, the medicine pocket is produced by isolation from a mold of the medicine pocket, for example a sheet. In this sense, the sheet is understood to mean a rectangular structure which is preferably similar to the sheet. The sheets are preferably connected in a stacked form from a variety of materials and include films or sheets, for example plastics, aluminum foil, paper and the like. For example, a medical pocket can be preferably formed from two stacks in which the medical wafer is located in between. In this case the layer order of the stack may be polyethylene / aluminum / polyethylene terephthalate, wherein the polyethylene layers each lie towards the medical wafer, with the polyethylene terephthalate layer facing outward.

Sheets are also understood to mean strips, ie elongated sheets, which can be wound, for example, on rolls (coils).

For isolation, the sheet is preferably introduced into a separate manufacturing device and placed under the isolation device. Here, individual medication pockets are isolated from the sheet, preferably at the same time. The isolation product (medicine pocket and isolation residue) is then conveyed to the removal position. From this, the medicine pockets are removed one by one, for example, by the robotic arm. A special sensor can be mounted to the robotic arm to ensure that each medication pocket has been taken, transported and stacked into a cassette.

Preferably the medical pocket is isolated from the sheet by punching. This is a low cost and accurate isolation technique. Other isolation techniques, such as cleavage, can be similarly considered.

In a further preferred embodiment of the present invention, in a matrix-like arrangement a sheet corresponding to a medicine pocket, in which case there is a marking in each marking portion on each region edge, and in each case a medical wafer, It contains. In the sheet, the medical wafer is sealed by welding. In addition, apart from the marking, there may also be a tension on the sheet, which allows for identification of the medicament, for example. Preferably the sheet contains at least 4, at most 12 rows of zones. For example, four, eight, ten or twelve of the zones may be provided. Each row contains, for example, seven or fourteen zones.

In a further preferred embodiment of the invention, the zones in which the markings are located within the marking parts which follow each other are connected to each other in each row on the sheet. As a result, the medicine pockets can be removed from the sheet in a logical order, which are also stacked part-stack up one by one in this order. Multiple rows next to each other have zones that are identical to each other in adjacent rows of other columns. Multiple rows of zones are isolated to form a medication pocket, which in turn is fed to a different part-stack in each case.

In the manner according to the invention, this preferred method thus comprises the following steps:

i. Providing a mold of the medication pocket, wherein the mold of the medication pocket contains at least two adjacent rows of regions in which the medication pockets are formed by isolating therefrom, and within the marking portions where the markings on the regions leading from each other are connected to each other. Provided, or if appropriate, a marking medicated pocket located at the first end of the marking edge, followed by a marking medicated pocket located at the second end of the marking edge;

ii. Separating two or more adjacent rows from each other along one or more separation lines separating the rows, wherein a strip containing medicinal pockets that run into each other in the row is formed in a manner corresponding to the number of rows;

iii. Isolating medication pockets contained within each formed strip by removing each individual medication pocket from its strip; And

iv. Gradually a medication pocket with a marking located from one medication pocket to the next medication pocket, with each marking on the medication pockets in each stack arranged in subsequent marking portions, or where appropriate at the first end of the marking edge Stacking the isolated medical pockets of each strip to form a respective stack, followed by a medical pocket with markings located at the second end of the marking edge.

In particular, the method may comprise the following process steps:

i. Carrying the mold of the medicine pocket in the transport direction, wherein the mold of the medicine pocket contains two or more adjacent rows of zones leading to each other in the transport direction, the rows of which extend parallel to the transport direction, and the rows of zones where the markings continue to each other A marking pocket provided on the marking portions that follow each other or, if appropriate, with a marking medicine pocket positioned at the first end of the marking edge, followed by a marking medicine pocket positioned at the second end of the marking edge;

ii. Separating two or more adjacent rows from each other along one or more dividing lines along the conveying direction, wherein a strip containing medicinal pockets leading from one another in the conveying direction is formed in a manner corresponding to the number of rows;

iii. Isolating medication pockets contained within each formed strip by removing each individual medication pocket from its strip; And

iv. Gradually a medication pocket with a marking located from one medication pocket to the next medication pocket, with each marking on the medication pockets in each stack arranged in subsequent marking portions, or where appropriate at the first end of the marking edge Stacking the isolated medical pockets of each strip to form a respective stack, followed by a medical pocket with markings located at the second end of the marking edge.

This method according to the invention has the advantage that the manufacture of the stack takes place with higher reliability than the prior art, in which the medical pockets which are combined to form the stack are first collected in the strip and are only isolated immediately before being stacked up one by one. Because they are separated from each other by This reduces the risk of errors occurring in the order of the medication pockets in the stack. As a result, the exact number of medication pockets and their order in the stack can be more easily realized.

Furthermore, it is possible to check whether the stack has been satisfactorily generated based on the marking on the medicine pocket, for example in that the stack is handed over automatically or automatically, and the order of markings on the medicine pockets which follow each other in the stack is checked. have

The fact that the medicine pocket is provided with the marking in the manner according to the invention means that the user has the possibility of using the stack to determine whether or not he or she has already taken a dose of medicine within that time period. As a result, the progress of the medication wafer dose can be monitored with the aid of marking on the medication pocket. Thus, in addition to the general inspection function, marking takes on the additional function of quickly allocating a specific medical wafer to a particular dose period or time.

The mold of the medicine pocket for manufacturing a stack of medicine pockets which serves to store and provide a medical wafer comprises at least two, preferably at least four, and preferably two or more of the intersecting regions where the medicine pocket is created by isolating therefrom. Preferably up to 12, for example 4, 8, 10 or 12 adjacent rows, preferably they extend transverse to the longitudinal direction of the mold of the medicine pocket. Preferably, each medical pocket has a marking on one of the plurality of parts arranged next to each other at the marking edge. Moreover, the marking is preferably provided on each medicine pocket on the mold of the medicine pocket in such a way that the marking on the medicine pockets which are connected to each other in a row is provided in the marking portions which are connected to each other. If appropriate, in a row, a medicine pocket with markings located at the first end of the marking edge is followed by a medicine pocket with markings located at the second end of the marking edge.

In the manner according to the invention, the mold of the medicine pocket is used to produce a stack of medicine pockets which serve to store and provide the medicine wafer.

Moreover, the mold of the medicine pocket can also be used to make a dispenser device for storing and providing a medical wafer. Such an apparatus comprises i) a stack of medical pockets containing a medical wafer (preferably in each case there are seven marking portions at the marking edge and in each case one marking in one of the marking portions), and ii) a carrier in which the seven time marks on which the marking is aligned are preferably arranged above.

Preferably, the mold of the medicine pocket is in the form of a sheet with a zone corresponding to the medicine pocket. In a preferred embodiment of the invention, the sheet comprises six adjacent rows of medicinal pockets leading to each other, and seven medicinal pockets leading to each other in each row. When 28 medicine pockets per stack is the desired number, four sheets are thus needed for the simultaneous manufacture of six stacks.

In an alternative preferred embodiment of the invention, the mold of the medicament pocket can also be provided, for example in the form of an elongated strip, wherein such strip is wound on a roll (coil) and then unwound in the conveying direction for the method. It is possible. For example, the strip comprises six adjacent rows extending parallel to the conveying direction, of regions leading to each other in the conveying direction for the medicine pocket.

In a preferred embodiment of the method, on the mold of the medicine pocket, seven marking portions are located on each marking edge of the medicine pockets. Preferably the marking is located in the second medical pocket area. In this case, the areas leading from one another in the row on the mold pocket of the medicine pocket, such that the position of the marking changes gradually in the order of 7 from the medicine pocket to the medicine pocket, ie in each case from the first medicine pocket to the seventh medicine pocket. Marking of the phase is provided on the marking parts which follow each other. If the template of the medicine pocket contains more than seven zones, for example 14 zones, in each row, the order of the subsequent markings on the zones leading from one another in the row is from the beginning to the fourteenth medicine pocket from the eighth medicine pocket. It continues in such a way that it starts again. In other words, when viewed in the transport direction, it is preferable that seven medicine pockets which are connected to each other are located in each row on the mold pocket of the medicine pocket. As a result, after isolation and stacking of the medicine pockets, a stack of weeks can be obtained, and they can finally be stacked to form a monthly stack of 28 medicine pockets.

Such dimensions of stacks with medication pockets are particularly advantageous for use in contraception and hormone replacement therapy, in which case a dose of medication is once daily over several weeks, for example 4 weeks (28 days). It must be taken. By including 28 medication pockets in the stack, the user can use up the stack during this period in each case.

If a medical wafer is to be taken daily, in a preferred embodiment the time indication is the day of the week indication or the calendar day indication, the latter being indicated by the numbering of the dates. However, the day of the week indication is preferred and is advantageous over the day of day indication in that repetition may occur more frequently than in the case of the day of day indication. For the first day, since it is only necessary to select the appropriate day of the week, this makes it possible to provide the time indication on the carrier more easily. Day of week indicators, calendar days or other time indicators are preferably provided on the carrier at the beginning of the dose phase of the medical wafer.

Preferably, the template of the medicine pocket according to the present invention contains a medical wafer containing a medicine for contraception or hormone replacement therapy. Within the row of drug pockets, there may be a subpopulation of drug pockets containing no drug, but for example with a placebo, or with a drug wafer containing a medicament (two-stage medicament) that is different from other drug wafers. For example, there may be a placebo for every 25th-28th medication pocket in a row of medical wafers. Since the placebo does not contain any active substance, it has the advantage that the taking of the wafer does not need to be interrupted, for example in the case of contraceptives with a dosing period in which the medicament should not be taken.

Separation of two or more adjacent rows on the mold of the medicine pocket from one another along the dividing line, for example along the conveying direction, is preferably carried out by cutting. Isolation of the medical pockets contained in the formed strip is preferably carried out by cutting or punching. In certain embodiments of the invention, separating the strips from each other and isolating the medical pocket from the strips may in each case also be carried out by punching.

If the mold of the medicine pocket does not contain any holes for the medicine pocket, the hole can be introduced into the mold or medicine pocket of the medicine pocket before or after isolation, for example by punching.

Once the stack is completed by stacking the isolated medication pockets, the stack can then be arranged on the carrier. The medicament pockets on the carrier can be connected to the carrier by the connecting element. Alternatively, the medical pockets can be stacked on the carrier and connected by a connecting element in the stacked state. In both cases, improved stability is provided to the stack by the carrier, and the stack can be handled more easily. Moreover, the wafer is protected by the carrier against mechanical effects.

For example, a medication pocket can be stacked on each carrier in each case to create each first part-stack. This enables a particularly reliable manufacturing approach: the medical pockets are preferably kept in the carrier for use by the user. As a result, on the one hand, the necessary stability is achieved, which includes protecting the medical wafer from mechanical damage, and on the other hand, a time indication is provided on the carrier which serves to monitor regular dosing by the user. Can be. By the carrier, the medication pockets can also be held in combination in the stack. The fact that the medicine pockets of the first part-stack are already stacked on the carrier means that they can be more easily combined and maintained. This eliminates the process of transporting the finished stack to the carrier to otherwise secure the stack with the carrier.

Isolated medication pockets can be stacked directly on the carrier. In this case, the carrier may already contain the connecting element or part of the connecting element as well. This achieves the effect that the resulting stack is already mechanically combined and can no longer fall during subsequent handling. This enables a reliable manufacturing method. In connection with the first practice variant of the invention, after the manufacture of the first part-stack, additional medicine pockets are stacked on the first part-stack such that the additional medicine pockets are likewise retained by the connecting element. In connection with the second implementation variant of the invention, each additional part-stack, i.e., second, third, fourth part-stack, etc., in such a way that the medicinal pockets contained in the additional part-stack are likewise retained by the connecting element. It can also be stacked on the first part-stack. This procedure achieves an immediate fixation of the individual medication pockets so that the part stack or the final stack will no longer occur, for example during a transport operation.

Also preferably in the medical pocket there are holes which are aligned with each other and through which the connecting element can be sewn. As a result, the medicine pockets are connected to each other and at the same time preferably arranged to be movable relative to each other. This has the advantage of compensating for a small rise in the medication pocket caused by the medication wafer in the medication pocket. This allows the medication pockets to be placed on top of each other in the stack in a regular manner. In this way, on the one hand an aesthetically pleasing device is produced. On the other hand, minimal mechanical load is applied to the wafers in the stack, and consequently the wafers are carefully stored.

In a further embodiment of the invention, the carrier also has a guide element for guiding the medical pockets on the carrier. This achieves the effect that the medication pockets on the carrier can be stacked up one by one while their edges are substantially exactly coplanar, and then remain in this way.

It is advantageous for stack fabrication that the medical pocket is placed in a cassette and each one is stacked up one by one in the cassette. If a carrier is used, the carrier may first be placed in each cassette so that the medication pockets may be stacked thereon.

Preferably, the time indication is provided on the carrier in such a way that the time indication is aligned with the marking portion on the medicine pocket when the medicine pocket is combined with the carrier.

In a preferred embodiment of the invention, the stack can also be combined by means of connecting elements without carriers being used. In this case, the medicine pockets can be connected to the connecting element instead of the carrier when the medicine pockets are stacked up one by one in the first manufacturing device. In addition, a guide element may also be used in this case, in order to be able to stack the medical pockets with their edges exactly coplanar and stacking up one by one. The stack of pockets held together by the connecting element can then be exchangeably fastened to the carrier. For example, the carrier can be formed in such a way that the stack can be easily fastened to the carrier. This can make the stack interchangeable within the carrier, and consequently the carrier can be replenished with the stack. This allows for a more sophisticated design of the carrier since the wafer is used up again when not used up.

The connecting element can be, for example, a rivet or some other connecting element that holds the stack together in a manner that prevents manipulation. The connecting element is arranged to connect the medicine pockets to each other, so that they can move relative to each other. In the case of rivets, the connecting elements can in each case comprise two connecting element parts (for example in the form of rods), which can be fitted into one another or screwed in, or adhesively bonded to one another. Can be. The connecting element can also be in the form of a rod. In a further embodiment of the invention, the connecting element can also be formed in a compact type structure, which comprises two parts, in which the hole in the medicine pocket can be substantially completely filled when the connecting element is assembled. In particular, the connection element may comprise a box-shaped lower part in which ribs for passing through the hole are arranged therein, and another part which closes the box-shaped lower part. Furthermore, the box-shaped lower part of the box-shaped connection element can comprise not only a lip, but also a base plate, a wall located on the base plate and partially surrounding the medicine pocket, and consequently guiding the medicine pockets. In any case, it is to be understood that the connecting element refers to a component that is threaded into a hole in the medication pocket to connect the medication pockets. As a result, the ribs and rivets of the connection elements formed in a compact type structure can be understood as connection elements. In the case of a lip, additional proper holding of the foot and head of the lip is of course required to hold the stack together. Such an additional holding device can be realized by a box structure comprising, for example, a lower part and an upper part in the form of a box. Alternatively, differently designed foot and head portions that hold the stack together may also be provided at the feet and head of the lip. The lip can also be formed as a rivet with two rivet heads in the form of a lip. When the connecting element parts forming one or more connecting elements are assembled, these parts may be engaged with each other, preferably not separated from each other without breaking them, or they may be adhesively joined or welded to each other Or may be connected to each other by some other connection technology. In all such cases, what is known as a tamper proof closure, i.e. a closure that prevents manipulation is involved. It is particularly preferred that the connection of two or more parts forming the connecting element is achieved with a tight fit. A rivet means a connecting element comprising two or more parts which engage each other and are thereby connected to each other in a tight fit and which can also clamp the stack of medical pockets arranged therebetween by suitable head shaping. It is understood that.

The carrier is preferably made from cardboard, plastic or metal. Preferably, in order to protect the individual medication pockets, the carrier surrounds the stack of pockets. For this purpose, the carrier can be formed as an elongated strip which is folded back into the stack. For example, a front tab protruding on one side of the strip may be formed as a lid. Furthermore, tabs protruding on the other side of the strip can be formed, for example, as a lid. Appropriate closure means, for example hook-and-loop, pressure, magnet, insert or rubber-band closures, for example mounted on the lid and lid, for turning on the stack to close the carrier Can be.

The time indication may be provided on the carrier or on the connecting element.

The dispenser device containing the stack produced by the method according to the invention is preferably of an anti-counterfeiting structure. For this purpose, one or more security features are provided on the device such as imprinting, holograms, tilt images or other security features of the device that allow the authenticity of the device to be checked.

Preferably, perforations are introduced into each medicine pocket, respectively, which serve to tear off the second medicine pocket area of the medicine pocket containing the medicine wafer. A perforation line can be introduced into the mold of the medicine pocket, for example only before or after the marking is provided on the mold. The perforations enable the medical wafer to be easily removed from the stack, for example by removing or removing the second medical pocket area from the stack. After tearing off the second region, the first medication pocket region remains in the remaining stack.

In a preferred embodiment of the present invention, the perforations are not formed to reach the full width of the medicament pocket, but are shortened overall, merging into slits at both ends thereof. The slit creates a notch effect, which makes it easier to remove the second medication pocket area. For example, by means of a suitable punching tool a cutout line can be introduced.

In a further preferred embodiment of the invention, prior to stacking the isolated medicine pockets, a medication pack is formed such that a step-shaped series of cutouts is formed in the stack when viewed across all medicine pockets, and in this manner. The edge cutout is provided in each case additionally to the medication pockets so that the markings provided on the stomach are visible, with the additional step of increasing the cutout incrementally in the stack from the medication pocket to the medication pocket. For this purpose, on each medicinal pocket in the stack, a graphic mark at the edge, when viewed in the direction of transport, is, for example, in the form of a symbol such as a collar double dot, smiley face, company logo or crossbar. , Preferably provided, which is progressively eliminated by the introduction of a cutout. Cutouts, which may be punched, for example, from the medicine pockets during the manufacturing process, expose in the final stack the appearance of the graphic marks on the medicine pockets underlying in the stack, which can each be seen in the cutout area. Such graphic marks may already be printed on the mold of the medicine pocket. The cutouts and graphical marks that can be seen thereby have the advantage that the manufacturer or an appropriate monitoring device can easily check that the stack has been completed during the manufacture of the stack, and consequently the number of medication pockets in the stack.

In a preferred embodiment of the invention, this mark is provided on one of the aluminum layers or one of the polyethylene terephthalate layers.

The drawings described below assist in the general understanding of the present invention. However, these should not be understood to be limiting and are only intended to explain the preferred specific embodiments without excluding other preferred embodiments.

<Brief Description of Drawings>

1 shows a schematic diagram of the method sequence of the method according to the invention.

2 shows a layout view of a sheet in which a medical pocket is obtained by punching. 2A shows a variant of the sheet from FIG. 2.

3 shows a perspective view of a stack made from a template of medical pockets in an embodiment according to the invention.

Figure 4 shows a further embodiment according to the invention of a booklet of a wafer pocket containing a stack of pockets produced by the method according to the invention at various assembly stages. 4a shows a stack of pockets and a connection element. 4B shows a booklet of wafer pockets when opened. 4C shows the booklet of wafer pockets when closed. 4D shows a booklet of wafer pockets in a side view. 4E illustrates an alternative embodiment with a rubber band for closing the booklet of wafer pockets. 4F illustrates an alternative embodiment with tabs for closing the booklet of wafer pockets. 4G shows an alternative embodiment with a magnet closure.

Figure 5 shows a further embodiment according to the invention of a booklet of a wafer pocket containing a stack of pockets produced by the method according to the invention at various assembly stages. 5A shows the carrier before clamping the stack. 5ba shows a separate stack and connecting element + guide, respectively. Figure 5bb shows an assembly and clamped stack and connection elements, similar to Figure 5ba. 5C shows a booklet of open wafer pockets after being connected to a carrier. 5D shows a booklet of closed wafer pockets.

6 shows in a perspective view a further embodiment according to the invention of a booklet of wafer pockets containing a stack of pockets produced by the method according to the invention at various assembly stages. 6a shows a carrier with a connecting element and a guide. 6B and 6C show booklets of completed or partially opened wafer pockets after placing the stack in place. 6D shows a stack of closed wafer pockets. FIG. 6E shows a different arrangement of day strips, similar to FIG. 6A.

7 shows a side view of a further embodiment according to the invention of a booklet of a wafer pocket containing a stack made by the method according to the invention.

8 shows in a perspective view a further embodiment according to the invention of a booklet of a wafer pocket containing a stack made by the method according to the invention. There is a stepped cutout in the booklet of wafer pockets.

Like reference numerals in the drawings indicate like elements.

In FIG. 1, the method sequence of the method according to the invention is schematically shown by the manufacturing apparatus and the medicament mold used in the manufacture of the stack. The presented element can represent devices that can be used to perform the method. However, other configurations of the devices used may also be used, as long as the object according to the invention is met.

Sheet 7 containing medicinal pockets in the form of zones is fed to punching devices 26, 26 'in modules 30, 30', 30 ". The number of modules is the total number of medication pockets 4 and sheets to be included in the stack of pockets Based on the number of zones for the medicinal pockets in the rows contained in the bed, ie the number of medicinal pockets fed into each module, for example, a total of 28 medicinal pockets are combined in a stack and 7 in the row on the sheet. If there are four medication pockets, four modules should be provided.

In FIG. 2, an example of a layout of sheet 7 is shown, with a total of 6 × 7 = 42 medication pockets on the same number of zones 5. Zones are arranged in columns R and S. In this case, six columns and seven rows are provided. Columns and rows are for example indicated by arrows in FIG. 2. Zones located in rows on the sheet may be allocated to the stack. Zones of different rows can be allocated to different stacks.

The marking portion 18 on the marking edge of each zone and the zone area 8 ′ for the opening can be seen in zone 5 respectively. Within the marking portion, marking 3 is provided, for example by a printing process, to make it easier for the user to monitor the regular dose of the medication. It can be seen that the positions of the markings on the marking edges in the same row but in the same row are the same in each case, while the positions of the markings in the zones which are connected to each other in the column are connected to each other: when viewed from the bottom, the markings are lowest, second lowest, It continues in the third lowest marking part.

The six adjacent rows R presented, each with seven zones 5, are first cut into six strips 9 along the dividing line 11, and then the medication pocket is isolated from the strip 9. One strip is then further processed in each case by separating each individual medication pocket. Then, the medical pockets isolated in this manner are each stacked up one by one to form a main unit stack, for example. Subsequently, additional sheet 7 is processed by the same method. For example, six main unit stacks are created from sheets. By placing each additional 21 medicine pockets obtained from three additional sheet 7 on the six first main unit stacks obtained from the first sheet 7, a total of six stacks each containing 28 medicine pockets are formed. The fact that the medicinal pockets are cut from each strip or separated by punching only after strip 9 is preferably produced first means that the medicinal pockets belonging to the stack are held together in the form of a strip as long as possible. In this way of carrying out the method, the medicine pockets are separated from strip 13 only immediately before the medicine pockets are stacked up one by one. As a result, classification mistakes are avoided, which increases the reliability of stack generation.

A modification of the template of the medicine pocket from FIG. 2 is shown in FIG. 2A. This template 7 differs from that described above in that eight rows R, each with seven zones 5, are provided for the manufacture of the medication pocket. Moreover, in each zone there is an elliptical hole 8 punched out, a perforation line 12 whereby the first medication pocket region and the second medication pocket region are thereby connected to each other, as well as the side notches 13 of the perforation line. Furthermore, on both longitudinal sides of the mold 7 there is a protruding edge 14, in which a continuous perforation 15 is located. This perforation 15 is used to transport the mold 7, for example in the same way that the film proceeds. Row R of sheet 7 is arranged parallel to the direction in which the sheet is conveyed (arrow 10) during the manufacture of the medicine pocket.

Adjacent to the hole 8, marking portion 18 and marking 3 within the marking portion can be seen in zone 5. Within row R of the seven zones 5 (numbered in circles, see FIG. 2) which follow each other, the position of marking 3 changes gradually from zone to zone. On the other hand, the position of marking 3 in the row S remains unchanged.

The mold 7 of FIG. 2A differs from that described above according to FIG. 2 in that eight rows R with seven zones 5 each are provided for the manufacture of a medicine pocket.

According to Fig. 1, two such sheets 7 are supplied to each of the modules 30, 30 ', 30 "(see arrows in Fig. 1). The areas on the sheets corresponding to the individual rows R and S are similarly schematically shown in Fig. 1 Presented.

Sheets 7 are simultaneously placed on the punching tables 27, 27 'of the punching devices 26, 26'. Here, medicine pocket 4 is punched in a manner corresponding to the zone edges in FIGS. 2 and 2A. At the same time, opening 8 is also formed by punching. The punching table can be displaced in parallel in a manner corresponding to the arrow. As a result, the sheet can be arranged under the punching device before punching, can be aligned if appropriate, and can be displaced from the punching area after punching out of the medicine pocket (upward in FIG. 1). As a result, it is possible for the medicine pocket already punched out and finally also the punch residue to be removed from the punching table continuously while additional sheets are already laid on the punching table. For this purpose, a punching operation takes place in the front region (lower region in FIG. 1) of the punching table, to which, for example, by applying a vacuum, the sheet for punching is also first stacked and fixed. After punching, the punching table is displaced backwards (away from the sheet feed) so that the punched medicine pockets can be removed from the punching table.

A special robotic arm (not shown) is used to remove the individual medication pocket 4, to ensure that the medication pocket individually picked up here is reliably picked up, transported reliably, and reliably rebuilt. Sensors are installed. Using a robotic arm, medication pockets are stacked in cassettes 25, 25 ', 25 ", 25"' .... Before the first medication pocket is placed, in each case there is a carrier for the stack of pockets in the cassette, which carrier contains rivets or other connecting means. The medicine pockets lie on each carrier in such a way that the rivet is sewed in the opening 8. As a result, the medication pockets are retained and additionally guided. Even if the stack of formed pockets is improperly processed, it can no longer be easily dropped.

Within each of the modules 30, 30 ', 30 ", there are 12 cassettes. Thus, since each sheet contains 6 rows R of medicine pockets, two sheets 7 can be fed to the module simultaneously, respectively. Sheets 7 fed to the module are punched at the same time In addition, in each module, punched pockets 4 of a specific row S are introduced into the cassette at the same time.

Once all of the medication pockets 4 of sheet 7 in modules 30, 30 ', 30 "are transported into corresponding cassettes 25, 25', 25", 25 "'..., part-stacks are made here. In each case, each first part-stack in the first module 30 contains seven medicine pockets .. In the second module 30 ', the second part-by-stack by stacking seven medicine pockets on the first part-stack. As a result, the second part-stack contains 14 medicine pockets, and so on.

After each completion of the part stack, all cassettes 25, 25 ', 25 ", 25"' ... of modules 30, 30 ', 30 "are simultaneously displaced to the right. As a result, the cassettes of the first module 30 The second module 30 'is reached and the cassettes of the second module 30' continue to reach the third module 30 ".

After the cassettes 25, 25 ', 25 ", 25"' ... have been displaced from one module 30, 30 ', 30 "to the right-sided module, the medication pocket 4 punched out of the sheet 7 , 30 ', 30 "cassettes 25, 25', 25", 25 "'... As a result, the first part-stack of the medicine pockets is in turn formed in the first module 30. In additional modules 30 ', 30 ", additional medication pockets are added to the already existing part-stack, so in this case a part-stack with 14 medication pockets is formed in the second module 30' and 21 medication pockets Part-stacks are formed in the third module, and a final stack with 28 medicine pockets is formed in the fourth module 30 ".

After the stack of pockets is completed in the fourth module 30 ", the stack is removed, the rivet connection on the stack is closed, and the carrier strip is folded to fold to protect the stack.

3 shows a stack 100 of medicinal pockets 4, 4 ', 4 "which serve to store and provide medicinal wafer 2, prepared by the preferred method, wherein the medicinal pockets are connected to one another after stacking or during stacking Each medication pocket 4, 4 ', 4 "has marking 3 in one of the plurality of marking portions 18 arranged next to each other at the marking edge, respectively, on the marking edge (shown only in the upper medication pocket 4). The medication pockets 4, 4 ', 4 "have a second medication pocket region 11 and a first medication pocket region 10, wherein each of the holes 8 is aligned with each other. The connecting element 200 is threaded into the hole 8. The connecting element 200 is The medicine pockets 4 are connected to each other and are arranged to be movable relative to each other.The holes 8 are formed as long holes and the connecting elements 200 are formed as rivets.The first medicine pocket area 10 and the second medicine pocket The regions 11 are connected to each other by the perforation line 12, so that it is easier at the perforation line 12 to separate the medicine wafer 2 located in the second medicine pocket region 11 from the first medicine pocket region 10. In this case, the first medicine pocket Region 10 remains in stack 100.

In FIG. 4 a further embodiment of a booklet of wafer pockets containing a stack of pockets 100 produced by the method according to the invention is shown in perspective. The stack 100 of wafer pockets of FIG. 4 is formed in substantially the same way as the booklet of the wafer pockets according to FIG. 3, but unlike FIG. 3, the marking 3 and marking portion 18 are not located adjacent to the perforation line 12, and the medical pocket area It is located on the opposite edge of 11.

Stack 100 of pockets includes a number of medication pockets 4, 4 ', 4 ", for example 28 pockets, of which only the uppermost medication pocket 4 is visible. There is a second medication pocket region 11 and a first medication pocket region 10. The medical pocket in each case contains the welded wafer 2. At the lower edge 17, which is the marking edge, there is a marking portion 18. On one of the marking parts, there is marking 3. In a second medication pocket (not shown) under the upper visible medication pocket, this marking is provided on the marking portion which lies next to the first marking portion where the marking on the uppermost medication pocket is located.

The first medication pocket region 10 and the second medication pocket region 11 are each connected to each other by a perforation line 12, wherein the perforation line is formed shorter overall than in FIG. 3, ie, over the entire width of the medication pockets 4, 4 ′, 4 ”. Rather, it merges into slit 13, 13 'at both ends, and this slit acts like a notch. By making it easier to detach the second medication pocket region 11 from the first medication pocket region 10 at the perforation 12, There is an effect of making it easier to remove the wafer 2. After removing the second medical pocket area 11, the first medical pocket area 10 remains in the booklet of the wafer pockets. In the form of a long hole 8), in the booklet in the assembled state, the rivet 200 or lip passes through it.

In this embodiment, in contrast to FIG. 3, the medicinal pockets 4, 4 ′, 4 ″ comprise a compact connection element 200 comprising a lower connection element part 210 and an upper connection element part 220, which completely fill the holes 8 in an assembled state. And the connecting element is formed as a rivet, on top of the stack of pockets 100, a two-part rivet 200 is presented: the rivet has a lower part 210 and an upper part 220. The lower part has a long hole 8 from below. Columns of rivet holders 211, 212 are fastened on the base plate 213, spaced from each other in such a way that the outer sides of the rivet holder are loosely laid against the rounded ends of the long holes. This outer side is slightly inclined upwards so that the medication pockets slide easily onto the rivets with their respective long holes (an enlarged view of the rivet holder 212). Once the entire stack of pockets has been formed, the rivet is closed by pressing the upper rivet part 220 between the columnar rivet holders. The sides are in the shape of interlocking saws, which interlock with each other Once the rivets are closed, the stack of pockets can be handled without problems, without fear of damaging the integrity of the stack during handling. A stack of these can also be used to refill the carrier In Fig. 4d it is shown that the rivet is made to be of a length such that the medical pockets are comparable vertically, as a result of which the thickness of the wafer pocket area on the pocket as compared to the other area is shown. The difference in can be tolerated, as well as the medication pockets sliding on the rivet without friction.

In the manufacture of the stack 100, the lower connecting element 210 is held by, for example, a holding device or, if appropriate, by a carrier, and the isolated medicine pocket 4, 4 ′, 4 ”or the final stack 100 is opened by holes 8. Over the lower connecting element portion 210. The connecting element 200 is then closed by placing the upper connecting element portion 220 thereon.

For example, the lower rivet portion 210 is preferably fastened on the carrier strip 300. When the first part-stack is produced from the medication pocket 4, the carrier strip is preferably first placed into the cassettes 25, 25 ', 25 ", 25"' ... (FIG. 1) together with the lower rivet portion. The medical pockets then lie on this strip, with the lower rivet portion fastened on the carrier strip respectively sliding into the long hole 8 of the pockets, on the one hand guiding the pockets to fix its position, on the other hand Also keeps them.

After all the medicine pockets in the booklet of wafer pockets have been stacked up one by one, the day strip 350 is provided on the carrier strip 300. The day strip is provided in a manner aligned with the marking portion 18 on the medication pockets 4, 4 ', 4 ". This allows the user to confirm on which day the wafer 2 of the medication pocket 4, which is placed on the top, should be taken.

The carrier strip 300 then folds back at both the upper and lower ends in such a way that the upper end forms a lid 320 for the booklet of wafer pockets. For example, information about the name of the manufacturer and the medication may be provided on the lid. The cover substantially covers the entire area of the medication pocket 4. After turning and folding, this is fixed by pressing the upper rivet part 220 between the columnar rivet holders 211 and 212 of the lower rivet part 210.

The lower end of the carrier strip 300 is similarly folded to form the lid 330 for the medication pocket 4. A booklet of wafer pockets in the closed state can be seen in FIG. 4C. Lid 330 touches over lid 320. The two parts are connected to each other by a closure that can be dropped. For example, hook-and-loop fasteners 410 and 420 may be provided on the inner side of the lid and the outer side of the lid. Hook-and-loop closure is shown in FIG. 4D. The magnet closure is shown in FIG. 4G. For this purpose, for example, a metal strip is provided at the edge of the lid 330, preferably over the entire width of the lid, for example a magnetic metal strip is placed on the edge area of the lid 320, likewise. It is preferably provided over the entire width of the cover.

An alternative embodiment of a booklet of wafer pockets is shown in FIG. 4E: a rubber band 430 is provided instead of a hook-and-loop closure or a magnet closure, which band is fastened to the lower portion of the carrier 300, to close the booklet. The cover is pulled over 320.

Additional embodiments of the booklet of wafer pockets are shown in FIG. 4F. In this case, a tab 440 formed by punching and bent down is provided on the lid 320, which tab may engage the long hole 450 in the lid 330 when the booklet of wafer pockets is closed.

In FIG. 5, a further embodiment of a booklet of wafer pockets containing a stack of pockets 100 produced by the method according to the invention is shown in perspective at various assembly stages.

Stack 100 of pockets includes a number of medication pockets 4, for example 28 pockets, of which only the top medication pocket is visible. The medical pocket contains the welded wafer 2. At the lower edge 17, which is the marking edge, there is a marking portion 18. On one of the marking parts, there is marking 3. In a second medication pocket (not shown) under the upper visible medication pocket, this marking is provided on the marking portion which lies next to the first marking portion where the marking on the uppermost medication pocket is located.

Medicine pocket 4 is notched on two sides in the upper region at 13, 13 ′, with perforation 12. Moreover, there is a long hole 8 in the medication pocket, which lip 214 passes through in the booklet in the assembled state.

Above the stack 100 of the pockets of FIG. 5B, there is shown a fastening device 200 formed of two parts: the fastening device has a lower part 210 and an upper part 220. The lower portion includes lip 214 and frame 215, all of which are provided on base plate 213. The lip passes through the long hole 8 from below. Frame 215 represents the boundary of the base plate on three sides and partially on the fourth side. In the absence of such a frame, the medical pockets may reach beyond the perforated connection part. This frame also snugly surrounds the upper portion (first portion) of the medication pocket and, consequently, shows an external guide to the medication pocket, which is firmly fixed in the booklet of the wafer pockets without the medication pocket moving. The upper portion of the fastening device is formed by plate 220, which can be fastened with a tight fit or adhesively on the lower portion. In the case of an adhesive connection, the plate can be connected to the lower part, for example by ultrasonic welding. For connection to a tight fit, for example, an undercut is provided on one of the two parts, and a protruding part is provided on the other of the two parts.

Once the fastening device 200 is closed, the stack 100 of (clamped) pockets can be handled without problem, without fear that the integrity of the stack may be compromised during handling.

Preferably, the lower portion 210 of the fastening device 200 is fastened on the carrier strip 300, for example by adhesive bonding. When the first part-stack is created to produce a stack of medication pockets, the carrier strip is preferably combined with the lower portion 210 of each cassette 25, 25 ', 25 ", 25 for its creation from the medication pocket 4. "'... (FIG. 1) is placed first. Thereafter, the medical pockets are placed on this strip, with the lip 214 of the lower portion 210 fastened on the carrier strip, respectively, slipping into the long hole 8 of the pockets. Medicine pockets are held on the carrier strip by this lip and frame 215. Moreover, the position of the medicine pockets is thereby accurately fixed.

After all the medicine pockets in the booklet of wafer pockets have been stacked up one by one, the day strip 350 is provided on the carrier strip 300. The day strip is provided in a manner that is aligned with the marking portion 18 and consequently with the marking 3 on the medicine pocket 4 in each case. This allows the user to confirm on which day of the week the wafer in the top medicine pocket should be taken.

The carrier strip 300 then folds back at the lower end in such a way that the lower end forms a lid 330 for the booklet of wafer pockets. For example, information about the name of the manufacturer and the medication may be provided on the lid. The cover in this case substantially reaches the total area of the medicine pocket.

The upper end of the carrier strip 300 does not fold back. At this point, the fastening device 200 forms a box, which closes the booklet of wafer pockets at the top edge. A booklet of wafer pockets in the closed state can be seen in FIG. 5D. Lid 330 reaches over the fastening device. The two parts are connected to each other by a closure that can be dropped. For example, a magnet closure may be provided on the inner side of the lid and the outer side of the fastening device, for example a metal strip on one side and a magnetic metal strip on the other. Partial elements of the magnet closure may also be contained within each component in a hidden manner.

In FIG. 6, a further embodiment of a booklet of wafer pockets containing a stack of pockets 100 produced by the method according to the invention is shown in perspective in various assembly steps.

Stack 100 of pockets includes a number of medication pockets, for example 28 pockets, of which only the top medication pocket 4 is visible. The medical pocket contains the welded wafer 2. At the lower edge 17, which is the marking edge, there is a marking portion 18. On one of the marking parts, there is marking 3. In a second medication pocket (not shown) under the upper visible medication pocket, this marking is provided on the marking portion which lies next to the first marking portion where the marking on the uppermost medication pocket is located.

Medicine pocket 4 is notched on two sides in the upper region at 13, 13 ′, with perforation 12. Moreover, there is a long hole 8 in the medication pocket, which lip 214 passes through in the booklet in the assembled state.

In FIG. 6A, a fastening device 200 is provided on the carrier strip 300. The fastening device is formed of two parts; There is a lower portion 210 and an upper portion 220. The lower portion includes lip 214, frame 215 and base plate 213. The lip passes through the long hole 8 from below. The frame 215 is on the edge of the base plate 213. This shows the boundary of the base plate on three sides and partially on the fourth side. In the absence of such a mold, medicinal pocket 4 can reach beyond the perforated connection. This frame also snugly surrounds the upper part (first part) of the medicine pocket and thus guides the medicine pocket so that it is firmly fixed in the booklet of the wafer pockets without the medicine pocket moving. The upper portion of the fastening is formed by plate 220, which can be fastened on the lower portion with a tight fit or adhesively. Such a plate 220 may be adhesively connected to the carrier strip 300, for example (by adhesive bonding or the like).

The lower portion 210 of the fastening device 200 is fastened onto the carrier strip 300, for example by adhesive bonding. When creating a stack from the medicine pockets or the first part-stack from the medicine pocket 4, the carrier strip is preferably in combination with the lower part 210, cassettes 25, 25 ', 25 ", 25"' ... ( 1) first placed into or positioned first. The medical pockets then lie on this strip, with the lip 214 of the lower part of the fastening device fastened on the carrier strip, each slipping into the long hole 8 of the pockets. Medicine pockets are held on the carrier strip by this lip and frame 215. Moreover, its position is accurately fixed by the frame.

After all medication pockets 4 of the booklet of wafer pockets have been stacked up one by one, day strip 350 is provided on carrier strip 300. The day strip may be provided in both the position shown in FIG. 6A and the position shown in FIG. 6E. The day strip is provided in a manner aligned with the marking portion 18 on the medication pocket 4. This allows the user to confirm on which day of the week the wafer in the top medicine pocket should be taken.

The carrier strip 300 then folds back at the top end in such a way that the top end forms a lid 320 for the booklet of wafer pockets. For example, information about the name of the manufacturer and the medication may be provided on the lid. The cover in this case substantially extends over the entire area of the medication pocket 4 and overhang of the carrier at the lower end of the booklet.

The lower end of the carrier strip 300 is folded back in the manner in which block 340 is obtained. Lid 320 leads to a block. The two parts are connected to each other by a closure that can be dropped. For example, magnet closures may be provided on the inner side of the cover and the outer side of the block.

Once the connecting element is rotated and closed, the booklet of wafer pockets is assembled.

In FIG. 7, a further embodiment of a booklet of wafer pockets is shown. As in the case of the booklet of FIG. 5, the lid 330 of the carrier 300 is pulled from above to the stack 100 of pockets and covers it in the closed state. In contrast to the embodiment of FIG. 5, rivets were used as connecting elements 200. In that the protruding portion of the rivet is inserted into a hole in the lid, this rivet is used simultaneously with the corresponding hole in the lid as a closure to the booklet of the wafer pockets.

FIG. 8 shows a perspective view of a booklet of wafer pockets made from the mold of a medicine pocket, where the stack 100 is substantially similar to FIG. 4 but with side cutouts 16 in each case in addition to the medicine pockets 4, 4 ', 4 ". There is a cutout 16 on the edges of the medication pockets 4, 4 'and 4 ", which are common to the first and second medication pocket regions 10 and 11, respectively, with the medication pockets 4, 4' and 4" following each other. In the stack, the individual cutouts are set in such a way that the cutout increases from the top to the bottom of the medication pocket to the medication pocket in an incrementally larger manner. When viewed across all medication pockets 4, 4 ', 4 "in the stack 100, A step-shaped series of cutouts 16 is made from the medicine pocket to the medicine pocket. Cutout 16, for example punched out of each medication pocket 4, 4 ', 4 "during the manufacturing process, is introduced into the area of cutout 16 on the medication pocket 4', 4" underlying below in the stack 100, respectively. Expose 21 (indicated by double dots).

In this embodiment, the stack 100 is arranged on the carrier 300. The stack 100 and the carrier are connected to each other by three rivets 200, 200 ', 200 ". Only one rivet 200' or, for example, a connection element according to Figure 4 is used to connect the stack 100 to the carrier. Often it is possible: on the topmost medicine pocket 4, marking 3 and marking part 18 can be seen in the second medicine pocket area 11.

In this embodiment, the carrier 300 has an area 360 protruding beyond the lower edge of the second medical pocket area 11, on which area a time indicator 350 (day of the week strip), wherein the time indication (here day indication) Water) is aligned with the marking part 18.

A time indicator 350 is provided, for example by adhesive attachment, with the day indications in German "Mo", "Di", "Mi", "Do", "Fr", "Sa" and "So". . The strip is made in such a way that the indication of the first day of the week appears on the far left. The first marking 3 aligned with day "Mo" is provided on the topmost medication pocket 4. The additional marking 3 is not visible because it is obscured by the medication pocket 4 placed thereon.

Claims (34)

Marking (3) in one of the plurality of marking portions 18 arranged next to each other at the marking edge 17 on the marking edge 17 on each medicine pocket 4, 4 ', 4 ". Each of these is a method of manufacturing a stack 100 of medical pockets 4, 4 ′, 4 ″ that serve to store and provide a medical wafer 2, wherein at least one stack ( The medicine pockets 4, 4 ′, 4 ″ in which the marking 3 is located in the marking portions 18 which run into each other within 100 are connected to each other and, where appropriate, at the first end of the marking edge 17. A medication pocket 4, 4 ′, 4 ″ with a marking 3 positioned therein is placed in the medicine pocket 4, 4 ′, 4 ″ with a marking 3 positioned at the second end of the marking edge 17. Subsequent to stacking the medication pockets (4, 4 ', 4 ") one by one to form one or more stacks (100). The method of claim 1 comprising the following process steps:
a) in each of the first part-stacks so that the medicine pockets 4, 4 ′, 4 ″ in which the marking 3 is located in the marking parts 18 which follow each other, and if appropriate Medicine pocket with marking 3 with marking 3 located at first end of marking edge 17 Medicine pocket with marking 3 with second end of marking edge 17. Stacking the medication pockets 4, 4 ′, 4 ″ one by one in the first manufacturing device 30 so as to follow (4, 4 ′, 4 ″) to form one or more first part-stacks;
b) so that the medical pockets 4, 4 ′, 4 ″ in which the marking 3 is located in the marking parts 18 which are connected to each other in each part-stack formed in this way are connected to each other and, where appropriate, marked Medicine pocket (4, 4 ', 4 ") with marking (3) located at the first end of the edge (17) with medicine pocket (3) with marking (3) located at the second end of the marking edge (17) Stacking additional medication pockets 4, 4 ′, 4 ″ on the one or more first part-stacks in the second manufacturing device 30 ′, followed by 4, 4 ′, 4 ″);
c) if appropriate, by stacking additional medication pockets 4, 4 ′, 4 ″ in the additional manufacturing device 30 ″ on each of the one or more part-stacks produced in the second or additional manufacturing device 30 ′, respectively. Repeating process step b) one or more times to finally form one or more stacks of medicine pockets 4, 4 ', 4 ". The method of claim 2, wherein the first part-stack is created in the first manufacturing device 30 by stacking the medication pockets 4, 4 ′, 4 ″ one by one, and at least one second and third part-stack. Stacking these additional medication pockets 4, 4 ′, 4 ″ on the previously formed part-stack, respectively, in the second and third manufacturing apparatus 30 ′, wherein one or more stacks 100 are added to the additional medication. Characterized in that it is produced in the fourth manufacturing apparatus (30 ") by stacking pockets (4, 4 ', 4") on each third part-stack. The method of claim 1 comprising the following process steps:
a) so that the medicine pockets 4, 4 ′, 4 ″ in which the marking 3 is located in the marking parts 18 which run into each other in each first part-stack and in the further part-stack are connected to each other, and Where appropriate, a medical pocket (4, 4 ', 4 ") with a marking (3) located at the first end of the marking edge (17) with a marking (3) located at the second end of the marking edge (17) One or more first part-stacks in the first manufacturing device 30 by stacking the medication pockets 4, 4 ′, 4 ″ up one by one, leading to the medication pockets 4, 4 ′, 4 ″, and In each case forming one or more additional part-stacks in additional manufacturing apparatus 30 ', 30 ";
b) the medical pockets 4, 4 ′, 4 ″ in which the marking 3 is located in the marking portions 18 that run into each other in each stack 100 are connected to each other and, where appropriate, the marking edge 17. Medicament pockets 4, 4 with markings 3, located at the first end of the medicament pockets 4, 4 ′, 4 ″ with markings 3 located at the second end of the marking edge 17. One or more stacks of medication pockets 4, 4 ', 4 "by stacking one or more first part-stacks and additional part-stacks formed in process step a) one by one up, so as to Forming). Method according to claim 4, characterized in that the four part-stacks are stacked up one at a time in each case to form in each case a stack (100) of medicinal pockets (4, 4 ', 4 "). Method according to one of the preceding claims, characterized in that the seven marking portions (18) are located on the marking edges (17) of the respective medicine pockets (4, 4 ', 4 "). . 7. The method according to claim 1, wherein the seven medicine pockets (4, 4 ′, 4 ″) are stacked up one by one in each case to form a first part-stack. 8. The method as claimed in claim 2, wherein two or more first part-stacks are simultaneously created by stacking up the medication pockets 4, 4 ′, 4 ″ one by one in each case. 9. How to. The medicine pockets 4, 4 ′, 4 ″ in each case so that a part-stack is produced in the cassette 25, 25 ′, 25 ″, 25 ″ ′. ) Are stacked up one by one. The medical pockets 4, 4 ′, 4 ″ according to claim 1, wherein in each case the medical pockets 4, 4 ′, 4 ″ are formed so that each first part-stack is created on the carrier 300. Stacking up one by one. 11. The carrier 300 according to claim 10, wherein the carrier 300 has one or more connecting elements 200 to hold the medicine pockets 4, 4 ', 4 "on the carrier 300 and the additional medicine pockets 4, Additional medicine pockets 4, 4 ′, 4 ″ such that the medicine pockets 4, 4 ′, 4 ″ contained in the 4 ′, 4 ″) or additional part-stack are likewise retained by the connecting element 200. Or an additional part-stack of medicine pockets (4, 4 ', 4 ") is stacked on the first part-stack. The method according to claim 11, wherein there is also a guide element (215) for guiding the medicine pockets (4, 4 ′, 4 ″) on the carrier (300) in the carrier (300). 13. A method according to any one of claims 10 to 12, characterized in that a time indication (350) is provided on the carrier (300) such that the time indication (350) is aligned with the marking portion (18). 14. The method of claim 13, wherein the time display (350) is a day of the week display. The method according to any one of the preceding claims, characterized in that the medical pockets (4, 4 ', 4 ") are produced by isolation from the mold (7) of the medical pocket. The method of claim 1, comprising the following additional steps:
i) providing the mold 7 of the medicine pocket, wherein the mold 7 of the medicine pocket is two of the regions 5 in which the medicine pockets 4, 4 ′, 4 ″ are formed by isolating therefrom. A marking (3) on the zone (5) containing at least adjacent adjacent rows (R) and leading to each other in the rows (R) is provided in the marking parts (18) leading to each other;
ii) medicinal pockets (4, 4 ', 4 ") separating two or more adjacent rows (R) from one another along one or more dividing lines (11) separating the rows (R) and running into one another in the rows (R) A strip 9 containing is formed in a manner corresponding to the number of rows R;
iii) isolating the medical pockets 4, 4 ′, 4 ″ contained in each formed strip 9 by detaching each individual medical pocket 4, 4 ′, 4 ″ from its strip 9. ; And
iv) Gradually from one medication pocket 4, 4 ', 4 "to the next medication pocket 4, 4', 4", medication pockets 4, 4 ', 4 "in each stack 100 Stacking the isolated medical pockets 4, 4 ′, 4 ″ of each strip 9 so that each marking 3 on) is arranged in subsequent marking portions 18, each stack 100. Forming). The process according to claim 16, wherein the process step i) further comprises conveying the mold 7 of the medical pocket in the conveying direction 22, wherein at least two rows R are parallel to the conveying direction 22. Adjoining, the zones 5 are connected to each other in the conveying direction, the dividing line 11 follows the conveying direction 22, and the medical pockets 4, 4 ′, 4 ″ are connected to each other in the conveying direction 22. How to feature. 18. The method according to any one of claims 1 to 17, wherein the stack (100) contains 28 medicinal pockets (4, 4 ', 4 "). 19. The stack according to claim 1, wherein the stack 100 is arranged on the carrier 300 and connected to the carrier by the connecting element 200, or the medicine pockets 4, 4 ′, 4 ") are stacked on the carrier (300) and connected to the carrier by a connection element (200). 20. The cut line according to any one of claims 1 to 19, which serves to tear off the second medical pocket region 11 of the medical pockets 4, 4 ', 4 "containing the medical wafer 2. And (12) are each introduced into respective medicine pockets (4, 4 ', 4 "). 21. The method according to claim 20, wherein the marking (3) is located in the second medical pocket area (11). 22. The method according to any one of claims 16 to 21, wherein separating two or more adjacent rows (R) from each other is performed by cutting. The method according to any one of claims 16 to 22, wherein isolating the medical pockets (4, 4 ', 4 ") contained in the formed strip (9) is carried out by cutting or punching. . 24. The method according to any one of claims 16 to 23, wherein the mold (7) of the medicine pocket is a sheet. The sheet according to claim 24, wherein each sheet (7) is connected to each other in six or eight rows (R) of adjacent medical pockets (4, 4 ', 4 "), and in each row (R). 7 medical pockets (4, 4 ', 4 "). 26. The cutout 16 according to any one of claims 16 to 25, wherein the cutout 16 prior to stacking the isolated medication pockets 4, 4 ', 4 ". From 4 ") to the medication pockets 4, 4 ', 4" to increase in the stack 100 incrementally, and when viewed across all medication pockets 4, 4', 4 ". An additional step is provided in which the edge cutout 16 is in each case additionally provided in the medicine pockets 4, 4 ′, 4 ″ so that the step-shaped series of 16 is formed in the stack 100. Characterized in that the method. 27. The method of any one of claims 1 to 26, wherein the medical wafer (2) is designed for use in contraception or hormone replacement therapy. Two or more adjacent rows R of medication pockets 4, 4 ', 4 "leading to each other, next to each other at the marking edge on the marking edge in each medication pocket 4, 4', 4" There is a marking 3 each in one of the plurality of marking portions 18 arranged therein, with the marking portion 3 on the medicine pockets 4, 4 ′, 4 ″ following in row R leading to each other. Serves to store and provide a medical wafer 2, the marking 3 being provided on each medicine pocket 4, 4 ′, 4 ″ on the mold 7 of the medicine pocket so as to be provided in the fields 18. Mold 7 of a medicine pocket for making a stack 100 of medicine pockets 4, 4 ′, 4 ″. 29. The mold (7) of the medicine pocket according to claim 28, wherein seven marking portions (18) are located on each marking edge. 30. The mold (7) of the medicine pocket according to claim 28 or 29, wherein seven medicine pockets (4, 4 ', 4 ") are located in each row (R). 31. The mold (7) of the medicine pocket according to any one of claims 28 to 30, wherein the medicine wafer (2) contains a medicine for contraception or hormone replacement therapy. 32. A medicament according to any one of claims 28 to 31, wherein the medicament pockets 4, 4 ', 4 "in each case additionally have a graphic mark 21 at the edge. Pocket molds (7). 33. A medical pocket according to any of claims 28 to 32 for manufacturing a stack 100 of medical pockets (4, 4 ', 4 ") serving to store and provide a medical wafer (2). Use of the mold (7). i) a stack 100 of medical pockets 4, 4 ′, 4 ″ containing the medical wafer 2, with in each case seven marking portions 18, and ii) the marking 3. 34. A method according to any of claims 28 to 33 for manufacturing an apparatus for storing and providing a medical wafer 2 comprising a carrier 300 with seven time marks 350 aligned thereon. Use of the mold 7 of the medicinal pocket according to.

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