JP2012516726A - Method of manufacturing a stack of drug pockets for storing and providing drug wafers, ready-made supplies of drug pockets for manufacturing the stack, and methods of using ready-made supplies of drug pockets - Google Patents

Abstract

  A plurality of drug pockets 4, 4 ′, 4 ″ each containing a drug wafer 2, one marking of a predetermined number of marking portions 18 arranged adjacent to each other at the marking edge 17 In order to reliably produce a stack 100 of a plurality of drug pockets 4, 4 ′, 4 ″ having a mark 3 in the part, the following method is carried out: each drug pocket 4, 4 ′, 4 ″ Are stacked on top of each other to form at least one stacked body 100 of a plurality of drug pockets. Therefore, in the at least one stacked body 100, a plurality of drug pockets 4, 4 ′, 4 ″, the marks 3 are arranged in the marking part 18 following each other and, if applicable, comprise the mark 3 arranged at the first end of the marking edge 17 Pocket 4,4 dosage ', 4 ", pharmaceutical pockets 4,4 comprises a mark 3 which is arranged on the second end of the marking for the edges 17', 4" follows the, stages.

Description

  The present invention relates to a method for manufacturing a stack of drug pockets for storing and providing drug wafers, including by use of ready-made supplies of drug pockets, and a laminate for storing and providing drug wafers. And a method of manufacturing a device for storing and providing a drug wafer. Each drug wafer contains a drug in a layered form. The drug wafer may in particular contain hormone drugs, in particular drugs for contraception or hormone replacement therapy.

  A medical wafer is a device in the form of a thin body containing a pharmaceutically active ingredient contained in a carrier for an active ingredient. The active ingredient in the wafer can be administered, for example, transmucosally, i.e. via the mucous membrane of the oral cavity, since the wafer is placed on or under the tongue and the active ingredient carrier dissolves. This is because the active ingredient is released. Each wafer is provided in a form enclosed within a plurality of pockets within a thin dimension to protect them from physical effects and other environmental effects such as moisture. According to U.S. Pat. No. 6,057,059, these pockets can comprise at least one carrier sheet and at least one top sheet, the sheet having at least a large area having two parallel side edges. Between the carrier sheet and the top sheet, a sheet-like or web-like substance (wafer) is enclosed in an airtight and moisture-proof manner. A device for storing and providing a drug wafer may contain a plurality of stacked sheet pockets therein. Obviously, drug wafers can be formed differently, since they do not have to comprise a large surface area sheet and a small surface area sheet, e.g. This is because a sheet can be provided. In order to manufacture the device according to Patent Document 1, the pockets in the described sheet, which accommodate the drug wafer, can be easily combined into a laminate and introduced into the device. The device described therein for storing and providing a wafer is a housing that is partitioned at least once, and for its lateral inner side, the side edges of each pocket stacked in the sheet. Comprises an abutting housing, while the carrier sheet edge projecting beyond the cooperating top sheet edge is located against the forward inner side. Each pocket stacked in the seat is pressed against the upper inner side of the housing by a spring. The upper region in front of the housing has two slits for separate provision of the carrier sheet and the top sheet, and the wafer is provided with the carrier sheet or with the top sheet. Is possible. The spring has the role of maintaining the pockets in the remaining sheets in the vicinity of the slits and positioning them for further removal after removal of the pockets in one sheet. A separation tool for separating the carrier sheet from the top sheet is disposed between the slits, and the uppermost carrier sheet has a region at the front edge of the top sheet. It is located in front of and abuts. A position-moving element that can be rotated about the axis of rotation functions to position each drug pocket outward from the housing.

  This device, whose drug pockets can be taken out one after another, is on the one hand a wafer intended to be taken at specific time intervals by a user using a drug pocket taken out to take a drug wafer. Has the disadvantage that it does not have the possibility to monitor whether it has already been taken or should still be taken. Thus, it is likely that two wafers will be taken instead of one wafer, or the user completely forgets to take the wafer.

  On the other hand, this closed device also prevents the user from knowing how many wafers he has already taken out or how long the prescribed process should continue. In addition, one particular disadvantage of this device is that when considering a closed design, the user can also see if the device actually contains all the medication pockets needed for treatment. It is not. Also, opening this compact device is not intended, and opening it will destroy it.

  To take hormonal drugs and other drugs, such as three times a day or once a day, in a prescribed process such as a prescription plan prescribed by the doctor treating the patient It is important that the drug is taken. However, most medications are taken only for a limited period of time, for example, until the condition to be treated is completely cured. There are also drugs that should be taken continuously over a very long period of time. In these cases, it can happen that the drug is not taken or not taken at the prescribed time. In that case, the success of treatment often becomes unstable. Thus, with particular emphasis on self-monitoring by the patient himself, sufficient attempts have been made to monitor drug use.

  The integrity of the device containing the drug wafer is a fundamental prerequisite for successful medical treatment. This is even more true when using drug wafers for contraception and hormone replacement therapy. For this reason, considerable effort is spent on quality assurance when manufacturing devices for time-dependent drug administration. In addition to this, of course, users of these devices are also interested in the possibility of monitoring.

  For monitoring the time and frequency of taking units of active ingredients in the form of tablets, coated tablets, etc., the prior art discloses what is known as a drug blister, ie a device for storing tablets, coated tablets, etc. In this case, tablets, coated tablets, etc. are accommodated in a plurality of pockets stamped in the first thin dimension, and the thin dimension is a second thin dimension that can be cleaved to seal each pocket. Connected to. If the dose of the tablet depends on a specific time, an indication such as each day of the week may be provided on the second thin body.

  For example, in patent document 2, the blister provided with the pocket with respect to the tablet arrange | positioned in a line form is provided. In the manufacture of the blister, each pocket is assigned in a well-defined manner for each day of at least one calendar month, and in the vicinity of each pocket each pocket is visually identified by a unique calendar day of the calendar month. Further continuous integer representations are arranged in a manner that can be identified, and the continuous integer representations are in the second thin dimension in such a way that they can be viewed from the back side of the second thin dimension. Arranged on the basis of the dehisable areas and each area is visually identifiable by a unique calendar day of the calendar month. This allows each pocket to be visually identified by a unique calendar day from both the front and back sides. As a result, taking daily tablets and observing user compliance can be made easier.

  Further, in Patent Document 3, there is an arrangement mechanism for receiving the tablets in an array form, and the arrangement mechanism is a blister pack having a predetermined surface area, and is a predetermined number of elements configured in the selected array. A blister pack in which tablets are placed, a container for receiving the blister pack, and a daily calendar that can be aligned with the arrangement of the tablets in the blister pack, the daily calendar selected And a blister pack is located near the edge and is displaceable to position the recorded start date on the first tablet in the tablet array, and an indicator is provided on the container. A description of the placement mechanism is given, as it has a positioning notch in the vicinity of the first tablet, indicating the first tablet to be taken.

  Further, Patent Document 4 discloses a case for receiving a blister pack, which has a first half and a second half connected to the first half. The first half of the case is formed as a pocket for receiving a blister pack, the first half comprising an outer portion, an inner viewing portion, and a first plurality of apertures in the viewing portion. A second plurality of apertures in the outer portion, wherein each of the first apertures is positioned in at least the container for each tablet in the blister pack after being received in the pocket. It is aligned with each of the second apertures as accurate as possible. The second half of the case includes a section for receiving display means representing each day of the week, and a plurality of windows representing the days of the week in the inner viewing area of the second half of the case in the area of the section. And the windows are arranged in such a manner that they are assigned to each row of each container of blister packs received in the pocket.

  However, these examples of devices that store and provide drug units relate to tablets in blister packs, and the manufacturing process is basically different from the manufacturing process for devices with drug wafers in drug pockets. Is different.

  A further example of helping a patient to ensure that the drug is taken in the prescribed process despite the patient's insufficient attention on a daily basis is, for example, a device that accepts a drug pack. Thus, it is a device that automatically records the removal of individual tablets. Various proposals for this are disclosed in Patent Document 5 (providing device for drugs, i.e. tablets), Patent Document 6 and Patent Document 7 (packs for drug samples in solid form, i.e. tablets), Patent Document 8 (medicaments, i.e. tablets Device and method for invoking that the drug is taken at the correct time), Patent Document 9 (blister pack placement mechanism), Patent Document 10 (device for recording pill removal from blister pack), Patent Document 11 ( A device for storing a medicine, i.e., a tablet and prompting for taking it), Patent Document 12 (a device for storing a drug, i.e., a container such as a tablet), Patent Document 13 (a device for supplying a tablet), Patent Document 14 (a pill -Holder and arousing device), Patent Document 15 (Pill Donor with Warning Function), and Patent Document 16 (Fixed Device) Drug moieties, i.e. dispenser for such tablets, and have been made in their usage).

German Patent No. 101 59 746 European Patent No. 0 166 763 European Patent 0 511 726 German Patent Application Publication No. 10 2005 032 015 German Patent Application Publication No. 198 50 890 German Patent Application Publication No. 197 39 438 German Patent Application Publication No. 195 16 076 German Patent Application Publication No. 198 52 602 German Patent No. 102 13 547 German Patent No. 41 34 237 European Patent Application Publication No. 0 191 168 German Patent Application Publication No. 198 36 100 German Patent Application Publication No. 102 17 929 US Patent Application Publication No. 2004/0050746 International Publication No. 01/54646 German Patent Application Publication No. 10 2005 048 515

  However, there is no suggestion for a monitored dose of a drug wafer that ensures that the drug wafer is administered reliably. A dispenser for a confectionery or drug in the form of a wafer is known, for example, from US Pat. However, this device has the disadvantage that it does not provide the user with the possibility of monitoring whether the prescribed dosing process has been followed for a certain period. Therefore, it is likely that two wafers are taken instead of one wafer, or that the user completely forgets to take a wafer. In particular, for the use of contraceptives, it is important that the drug is taken for a very long time without interruption and without irregularities. In this case, the user must pay attention to taking a batch of the drug every day without exception. Losing a batch leads to considerable risk, such as taking two doses of the drug on the same day. Especially in stressful situations, the user is more likely to forget to take a dose of the drug at a prescribed time interval, so this indication is particularly relevant as far as the drug wafer is concerned. There is a problem that there is no means to ensure that it is taken with high reliability. In addition to this, of course, such means also need to be provided by a manufacturing process that is perfectly functional and low cost.

  Thus, the primary purpose is the order presented, and according to the prescribed time interval and according to the time each wafer should be taken, in such a way that the user takes out the drug wafer from the device and takes it, It is to find a means that a medicine pocket for containing a medicine wafer is prepared for the user. For this purpose, the device must be able to allow the user to monitor the dosing of the prescribed drug wafer over a specific period. Devices that store and provide drug wafers are additionally intended to be suitable for daily use and to have the necessary mechanical stability. It is also intended that the drug wafer be stored reliably.

  A further object is that such dosage forms can be manufactured at low cost by being easily and concisely manufactured by a substantially perfect manufacturing process, so that the dosage form definitely allows the wafer to be taken. To ensure that it is done to the user. In order to produce the dosage form at low cost, it is also necessary that a large number of such dosage forms can be produced in a short time.

  Therefore, a further object of the present invention is to devise a method for manufacturing a laminate in such a way that a simple check on the integrity of the laminate is already possible during the manufacturing process with regard to the number of drug pockets. It is in. In particular, it is intended that the laminate does not contain too few or too many drug pockets by allowing perfect lamination. In this way, it is intended to reduce costs caused by defective products and costs for final inspection of manufactured laminates or for quality assurance.

  Yet another object of the present invention is a ready-made supply of drug pockets and a method for manufacturing a stack of drug pockets that serves to store and provide drug wafers from ready-made supplies of drug pockets. Thus, according to the method, there is provided a method that makes it possible to create a laminate that allows a user to monitor a drug wafer that has already been removed during use.

  These and other objects are directed to a manufacturing process claimed for a drug pocket laminate that serves to store and provide a drug wafer, and to manufacture such a drug pocket laminate. This is achieved by the ready-made supply of the claimed pharmaceutical pocket and by the claimed use of the ready-made supply of the drug pocket for producing such a stack of drug pockets. Preferred embodiments of the invention are specified in the dependent claims.

  The above method according to the present invention is a laminate of a plurality of drug pockets that serve to store and provide drug wafers, wherein each drug pocket is marked on the marking edge. It plays a role of manufacturing a laminate having a mark in one marked portion of a predetermined number of marked portions arranged adjacent to each other at the edge.

  The drug pocket of the drug wafer typically comprises a base or bottom sheet and a top sheet. The top sheet may be connected to the base or bottom sheet by, for example, adhesive bonding or welding, preferably by strip-like connecting parts extending along each side edge of the top sheet, and vice versa. Is the same. Furthermore, in a particularly preferred embodiment, the base or bottom sheet and the top sheet can each have a protruding tab, which in each case is not connected to each other at at least one side edge. This makes it much easier for the wafer contained in the drug pocket to be opened by separating the drug pocket because the two sheets are This is because it can be easily grasped. Between the base or bottom sheet and the top sheet, a drug wafer is preferably enclosed in an airtight and moisture-proof manner in the region formed by the joint. The pockets in each of the sheets can have a slight height increase in view of the manner in which they are formed, or just in the region of the wafer as a result of the latter.

  The dispensing device to be manufactured by the above method according to the present invention for storing and providing a drug wafer comprises a plurality of drug pockets comprising drug wafers in the form of a stack (of a plurality of pockets). In order to allow the user to monitor whether the drug wafer has already been taken or should still be taken at a specific time interval, the device may be parallel to the edge of the drug pocket. In particular, a time display can be arranged. Further, the marks arranged on the plurality of drug pockets that follow each other in the laminate are aligned with the time display portions that follow each other, and if applicable, the marking edge in the laminate. The medicinal pocket with the mark arranged at the first end of the medicinal pocket is in a manner that follows the medicinal pocket with the mark arranged at the second end of the marking edge. Marks are deployed on each. In this last mentioned case, this is always the case when a larger number of drug pockets are placed in one laminate than the number of marked portions on each drug pocket, In each marked part, a series of marks following each other is repeated. Thus, in the laminate, each mark follows a medication pocket that follows each other, but whenever one medication pocket has a mark in the last marked portion, the next medication pocket in the laminate. Again has a mark in the first marked part. Next, the plurality of drug pockets that follow in the laminate each have a mark in a marked portion that follows each other.

  For reliable self-monitoring by the user, according to the present invention, once the stack has been received in the dispensing device that stores and provides a wafer, the marking edge is over the edge. The marks arranged in the are aligned with the time display portion. This allows the user to determine whether the wafer has been removed at a specific time interval.

  However, this laminate must be manufactured perfectly. This is because if a single drug pocket is lost from the stack, or if there are double drug pockets in the stack, the mark in a particular marked portion of a series of drug pockets in the stack Lost or doubled, the user may be confused and take inappropriate drugs, i.e. the user may forget to take the wafer, or within a prescribed time interval This is because two wafers may be taken instead of one wafer. Therefore, the manufacturing process for the laminate is such that the marks of the drug pockets that follow each other in the laminate are also in the marked portions that follow each other or, if applicable, the first of the marking edges. A drug pocket with a mark placed at one end must be fully developed in a manner that follows a drug pocket with a mark placed at the second end of the marking edge.

  In addition to this, it must be ensured that each laminate can be produced with high production efficiency, ie with a particularly high cycle rate.

Therefore, in order to achieve the above object, the following manufacturing process according to the present invention for the laminate is provided:
Since at least one laminate is formed by laminating each drug pocket on top of each other, the at least one laminate has a plurality of drug pockets that follow each other, and these marks follow each other. A drug pocket comprising a mark disposed at the marking portion and, if applicable, disposed at a first end of the marking edge, is disposed at a second end of the marking edge. Following a drug pocket with a marked mark.

  In this case, and in other cases in the present invention, reference is made to a stack of drug pockets or a stack of drug pockets stacked on top of each other, which means that a plurality of drug pockets are stacked on top of each other. In other words, for example, one drug pocket stacked on the laminate is taken to mean that it is placed on the laminate.

  The laminate produced by the method according to the present invention can be used to store and provide a drug wafer that is particularly useful for contraception or hormone replacement therapy.

In order to produce a stack of multiple drug pockets that serve to store and provide drug wafers, a ready-made supply of drug pockets is also provided, from which the individual drug pockets are separated. Can be formed.

  By deploying a mark on the marking edge in the drug pocket in each case, the user can in each case monitor whether the wafer has already been taken at the prescribed time interval. That is certain. This is done by checking whether the mark on the top of the drug pocket is aligned with the time display area corresponding to the time interval in question.

DETAILED DESCRIPTION OF THE INVENTION In a first preferred alternative embodiment of the invention, the manufacturing process comprises the following method steps:
a) In the first manufacturing apparatus, since a plurality of drug pockets are stacked on top of each other to form at least one first partial stacked body, each first partial stacked body follows the above. The mark pocket has a drug pocket that follows each other with the mark arranged, and if applicable, the drug pocket with the mark located at the first end of the mark edge is the mark Following a drug pocket with a mark located at the second end of the affixing edge;
b) In the second manufacturing apparatus, since a plurality of further pockets for drugs are laminated on the at least one first partial laminate, the partial laminates thus formed follow each other. There are drug pockets following each other in which the mark is arranged in the marked part, and if applicable, a drug pocket comprising a mark arranged at the first end of the marking edge, Following a drug pocket with a mark located at the second end of the marking edge;
c) if applicable, in a further production device, b) by laminating further drug pockets on said at least one partial laminate produced in said second or further production device Repeating at least once, and finally forming at least one laminate comprising a plurality of drug pockets.

  In this variant of the method, at least one first partial laminate is first made in the first production device and in a further production device onto the at least one first partial laminate. The fact that the pockets are laminated is specifically that at least in the first production device, when the further drug pocket is laminated onto the at least one first partial laminate in the further production device. The fact that one subsequent first partial laminate can be suitably made at the same time means that a very efficient manner of production is achieved. Thereby, each partial laminated body can be created simultaneously. The same applies first, at least instead of having the pharmaceutical pockets stacked on the at least one first partial stack in the second manufacturing device yet to produce at least one complete stack of pockets. This is the case when only one second partial laminate is created and a further drug pocket has to be laminated onto this at least one second partial laminate. Specifically, in the third manufacturing apparatus, the drug pocket is laminated on the at least one second partial laminate. The at least one third partial laminate produced thereby or at least one full laminate of the plurality of pockets produced thereby is likewise preferably suitable for the at least one first and at least one second laminate. This is the same as the above partial laminate, and so on.

  It is also preferred that after the creation of each partial laminate, it can be checked separately whether the partial laminate has been produced completely. This makes it possible to eliminate incomplete partial stacks from the manufacturing process before the complete stack of pockets is completed. This achieves the effect that additional drug pockets are no longer laminated on the already incomplete partial laminate. This increases the production capacity on the one hand and reduces the number of defective products on the other.

  In particular, in a further preferred embodiment of the present invention, in the first manufacturing apparatus, a plurality of drug pockets are stacked on top of each other to form a first partial laminate, and the second and third In the manufacturing apparatus, at least one second and third partial laminate is each created by laminating a plurality of additional drug pockets on each previously formed partial laminate, and In the fourth manufacturing apparatus, at least one complete stack of drug pockets is created by stacking a plurality of additional drug pockets on each third partial stack.

  In a further preferred embodiment of the invention, the at least one first partial laminate produced in the first production device and on the at least one first partial laminate in a further production device. And a further partial laminate produced and produced by laminating further drug pockets are produced simultaneously, i.e. onto the at least one first partial laminate in the further production device. Further laminating of the drug pockets is performed simultaneously with the creation of the at least one first partial laminate in the first manufacturing device, and of course the at least one first partial laminate is 2 Since it must be created in the first manufacturing device before being moved to the manufacturing device, a plurality of drug pockets are stacked there, so At least one second partial laminate or at least one full stack of packets can be formed. Of course, the same is true because a further drug pocket is laminated onto the at least one second partial laminate in a third production device, so that the at least one first and second parts are the same. This is also the case when at least one third partial laminate can be created simultaneously with the target laminate. This sequence can be made as desired, specifically by creating at least one fourth partial laminate in the fourth manufacturing device, or creating at least one full laminate of drug pockets. And can be continued by creating at least one fifth partial laminate in the fifth manufacturing device or by creating at least one full laminate of drug pockets, and so on. .

In a second variant of the invention, the method comprises the following method steps:
a) a plurality of drug pockets stacked on top of each other to form at least one first partial laminate in the first production device, and in each case at least one further in a further production device Since each partial laminate is formed, each first partial laminate and the further partial laminate have mutually following drug pockets in which the marks are arranged in the marked portions that follow each other. And, if applicable, a drug pocket comprising a mark disposed at the first end of the marking edge comprises a mark disposed at the second end of the marking edge. Follow the pocket, stage;
b) each at least one first laminate and said further partial laminate formed in method step a) are stacked together to form at least one laminate of drug pockets; In the body, the marked portions that follow each other have the following drug pockets that follow each other, and if applicable, the marks that are arranged at the first end of the marking edge. The drug pocket provided follows the drug pocket provided with a mark disposed at the second end of the marking edge.

  Thus, in this second variant of the invention, in method step a), the at least one first partial stack formed in the first manufacturing device and a further manufacturing device were formed. Further partial laminates (second, third, fourth partial laminates, etc.) are stacked on top of each other to form a pocket laminate, so that the laminate follows each other. There is a drug pocket that follows each other in which the mark is arranged in the marked part, and, if applicable, a drug pocket comprising a mark arranged at the first end of the marking edge, Follow a drug pocket with a mark located at the second end of the marking edge.

  In the preferred embodiment of this second modified embodiment of the invention, in each case, four partial laminates are first created, and these four partial laminates are then stacked on top of each other. Thus, in each case, one complete laminate composed of a plurality of pockets is formed.

  In a further preferred embodiment of this second variant of the invention, the at least one first partial laminate produced in the first production device and the further production produced in the further production device. The partial laminates are created simultaneously, i.e. the at least one first partial laminate, the at least one second partial laminate, the at least one third partial laminate, the at least one fourth. Each lamination of a plurality of drug pockets on top of each other to form a partial laminate or the like is performed simultaneously.

  In this alternative embodiment, in each case at least one partial laminate is first produced, and then the partial laminates are stacked by overlapping each partial laminate (previously produced separately) with each other. Due to the fact that, when combined with the body, at least one complete laminate of drug pockets is formed, in this case as well, any manufacturing process must be completed before the entire stack of pockets is formed. It is permissible for incomplete partial laminates to be excluded. As a result, on the one hand, it is possible to manufacture at low cost by minimizing the amount of defective products. On the other hand, the manufacturing process results in an increase in speed, since the drug pockets that would otherwise have been contained in the incomplete laminate are used to produce a perfect laminate. Because it can be done.

  In a further preferred embodiment of the above two modifications of the present invention (in the first modified embodiment of the present invention, except for the first partial laminate, onto each already formed partial laminate. By laminating the respective drug pockets, and in the second modified embodiment of the present invention, separately in each case, the respective drug pockets are stacked on top of each other, and as a result stacked on each other. By forming corresponding partial laminates to be bundled, i.e., first, second, third, etc., partial laminates) in each case at least 2 by laminating a plurality of drug pockets on top of each other Two first partial laminates are created simultaneously, at least two second partial laminates are created simultaneously, at least two third partial laminates are created simultaneously, and so on. For example, in each case, six or twelve first partial laminates are created by laminating a plurality of drug pockets on top of each other. This can be done in a suitable first manufacturing device by parallel movement of the plurality of drug pockets. These simultaneously created 6 or 12 first partial laminates are then transferred to a second manufacturing device, where 6 or 12 second partial laminates, or Six or twelve complete laminates of a plurality of pockets are manufactured simultaneously. Alternatively, the six or twelve first partial laminates are bundled with six or twelve second partial laminates in a second manufacturing device in a manner corresponding to the second modified embodiment. . These sequences can be continued as desired, for example, six or twelve second partial stacks in the first variant of the invention are transferred to the third production equipment. And where, by simultaneously laminating further drug pockets on 6 or 12 second partial laminates, or 6 or 12 second in the second variant of the invention. The partial laminate is then bundled with the third partial laminate in the third manufacturing device, so that 6 or 12 third partial laminates or 6 or 12 complete multiple pockets It is because a laminated body is created.

  According to this technique, the production is performed in a very efficient and high-speed manner because a predetermined number of partial laminates are produced simultaneously in a plurality of production apparatuses. However, for both variations of the above method, simultaneous lamination means that the respective drug pockets are laminated one on top of the other so that each partial laminate is synchronized, ie, “in the same cycle. It should not be understood to mean only that it is formed as if it were "or" synchronous. Rather, simultaneous lamination should be understood to also mean that each partial laminate is made substantially simultaneously. Each stack of pockets can be manufactured very quickly in this way. However, in this case, synchronous lamination that overlaps each other is preferable. For this purpose, a predetermined number of drug pockets are delivered simultaneously to each manufacturing device, and these simultaneously delivered drug pockets are then stacked on top of each other and synchronously. By laminating, each partial laminate is formed.

  In a further preferred embodiment of the invention relating to both variants of the invention, a plurality of drug pockets are in each case stacked one on top of the other to create a partial stack in the cassette. For this purpose, at least one cassette is preferably deployed, in which each drug pocket is placed and then stacked one upon the other. For example, six or twelve cassettes arranged in a row or in an annular shape can be deployed.

  Further, each cassette may be movable, for example, to move a partial laminate created in the cassette to a further manufacturing device, wherein each partial laminate is a part of the present invention. 2 is bundled with another partial laminate in a manner corresponding to the modified embodiment, since a further partial laminate is placed on the first partial laminate in the cassette. .

  Alternatively, each cassette may also be movable to move them to a second manufacturing device, where the first modified embodiment of the present invention is on the first partial stack. In accordance with the above, further drug pockets are laminated. For example, the first partial laminate can be formed by seven drug pockets. In the second manufacturing apparatus, next, seven drug pockets can be laminated on the first partial laminate as well. Thereafter, the second partial laminate, which temporarily contains 14 drug pockets, can be moved to a third manufacturing device where, for example, further 7 on the second partial laminate. A single drug pocket is laminated. Thereafter, the third partial laminate, which temporarily contains 21 drug pockets, can be moved to a fourth manufacturing device, where, for example, further 7 onto the third partial laminate. A single drug pocket is laminated. Basically, the process can be carried out in each case with any number of drug pockets and with any number of manufacturing devices in each of the manufacturing devices. For example, a laminate with 28 drug pockets can be produced in this way.

  If a wafer housed in a drug pocket is conducive to hormone replacement therapy, the pocket stack typically includes 28 drug pockets. The 28 drug pockets are 28 identical drug wafers for a single stage preparation, or 24 identical drug wafers for contraception in a two stage preparation, and Includes 4 additional drug wafers with placebo or different drugs, or 21 identical drug wafers in case of two-step preparation and 7 additional drug wafers with placebo or different drugs obtain. For a two-stage preparation, the drug pocket containing the wafer containing the placebo or other drug must be inserted at the beginning or end of the pocket stack. For this purpose, drug pockets containing wafers containing placebo or other drugs are preferably first bonded together in a separate manufacturing device to form a laminate, or In a separate manufacturing apparatus, the laminate is laminated on the partial laminate already created at the end of the lamination operation.

  In a further embodiment of the invention, a stack of pockets, eg used also for contraception, may also contain a number of drug pockets different from 28, specifically for example 30 drug pockets. In this case, can 10 drug pockets be added in each manufacturing device to the already existing partial laminate (or stacked on top of each other to create the first partial laminate)? Alternatively, seven drug pockets can each be added (over four times) and finally two more drug pockets can be added in a further manufacturing device.

  In yet another embodiment of the present invention, when used for contraception, each wafer may also be used for a system known as a resilient dosing system, in which case the first time spans at least 24 days and at most 120 days. During the one elastic dosing phase, the wafer is removed and the first elastic dosing phase is followed by an interruption phase, for example for 4 days. In this case, the pocket laminate may include, for example, 28, 56, 84, 112, or 120, or any other number of drug pockets. In this case, the detailed content of stacking the drug pockets on top of each other according to the present invention is based on the number of drug pockets placed in the stack in a corresponding manner.

  In a preferred embodiment of the present invention, seven marking portions may be disposed on the marking edge of each drug pocket. These marked portions in which one mark is arranged in one of the plurality of marked portions of the medicine pocket correspond to each day of the week, for example. In the assembled dispensing device that stores and provides the drug wafer, each marked portion is aligned with a corresponding time indicator, such as a day of the week indicator on the device, so that it is positioned at the top of the stack. One mark in the marked part on the drug pocket aligns with a specific day of the week display on the device, eg “Mo” for Monday, so that the wafer in this drug pocket To the user, that is, in this case, to be taken on Monday.

  Alternatively, for example, three marked portions corresponding to three times a day (morning, afternoon, evening) or a different number of marked portions corresponding to each requirement for frequency of taking medication Can be done.

  Further, for example, in each case, seven drug pockets may be stacked on top of each other to form at least one first partial stack. In each of the first modified embodiments of the present invention, in each case, seven additional drug pockets are then laminated on the at least one first partial laminate to form a second partial laminate. Seven additional drug pockets are laminated on the at least one second partial laminate, and so on. In the second modified embodiment of the present invention, in addition to the first partial laminate, second and third partial laminates each including seven drug pockets are created. Each partial stack is then stacked on top of each other.

  This approach may be particularly suitable whenever each medication pocket has seven marked portions corresponding to seven days of the week. In this case, if one wafer is taken per day in each case, each drug pocket in the partial laminate contributes to the taking of each wafer during one week.

  In a further preferred embodiment of the first variant of the invention, the laminate is produced in four production devices, where in each case seven drug pockets are laminated to each laminate. The In the second modification of the present invention, four partial laminates are created to form one complete laminate by laminating the drug pockets on top of each other, and these are the following: Bundled together. If in each case one wafer is taken per day and in each case there are 7 drug pockets in the partial laminate, the laminate will have 28 doses taken in 28 days. Wafers are combined.

  In a further preferred embodiment of the present invention, each drug pocket is created by singulation from a ready-made supply of drug pockets, for example from a thin body. In the above case, a thin body is understood to mean a rectangular, sheet-like shaped product. The thin body is preferably integrally bonded in a layered form from various materials and is made of, for example, a plastic film or sheet, aluminum foil, paper, or the like. For example, each of the drug pockets can preferably be formed from two thin layers with drug wafers disposed between the thin layers. In this case, the thin layer may have the following layer arrangement: polyethylene / aluminum / polyethylene terephthalate; each polyethylene layer is located against the drug wafer and the polyethylene terephthalate layer faces outward.

  Thin dimensions are also understood to mean strips, ie elongate sheets that can be wound, for example, on reels (coils).

  For singulation, the thin body is preferably fed into individual manufacturing equipment and placed under the singulation device. Therefore, the individual drug pockets are made into a single body from the thin body, preferably at the same time. The singulated product (each drug pocket and the residue resulting from the singulation) is then moved to the removal location. From there, each drug pocket is successively removed, for example, by a robot arm. The robot arm may be equipped with specific sensors to confirm that each medication pocket is grasped, moved, and loaded into the cassette.

  Each pocket for medicine is preferably made into a single body by punching from the thin body. This is a low-cost and accurate unitization technology. Other unitization techniques, such as cutting, can be recalled as well.

  In a further preferred embodiment of the invention, said thin body is a plurality of regions each corresponding to each drug pocket, one drug wafer in each case and each region edge in each case A plurality of regions including one mark in the marked portion above are included in an arrangement configuration like a matrix. In the thin body, each drug wafer is hermetically sealed by welding. Further, there may be additional printing on the thin body that allows the identification of the medicine, for example, apart from the mark. The thin body preferably includes at least 4 columns and at most 12 columns. For example, regions of 4 columns, 8 columns, 10 columns or 12 columns can be deployed. Each column includes, for example, 7 or 14 regions.

  In a further preferred embodiment of the invention, the regions in which the marks are arranged in marked portions that follow each other follow each other in each column of the thin body. As a result, each drug pocket can be removed from the thin body in a logical order in which the drug pockets are stacked on top of each other in the partial laminate. The predetermined number of columns located adjacent to each other preferably have regions that are each identical to adjacent regions of other columns. A predetermined number of column regions are singulated to form a plurality of drug pockets, which are then delivered to a different partial laminate in each case.

Thus, in the approach according to the invention, this preferred method comprises the following steps:
i) a ready-made supply of drug pockets comprising at least two adjacent columns each comprising a plurality of regions, wherein the plurality of drug pockets are formed from the ready-made supply by singulation Deploying ready-made supplies, wherein each mark is respectively deployed on a plurality of marked portions following each other in each region following each other in the column, or, if applicable, the marking A drug pocket comprising a mark disposed at a first end of the rim, following a drug pocket comprising a mark disposed at the second end of the marking edge;
ii) separating said at least two columns from each other along at least one separation line separating each column, each strip comprising a plurality of drug pockets following each other in each column; Formed in a manner corresponding to the number of the columns;
iii) separating each individual drug pocket from each of the formed strips to separate each drug pocket contained in the strips; and
iv) Since each of the elongated strips is formed by laminating the individual drug pockets, the respective laminates are formed, and sequentially from one drug pocket to the next drug pocket. Each mark on the drug pocket is located in a marking portion that follows each other, or if applicable, a drug pocket comprising a mark located at the first end of the marking edge. , Following a drug pocket comprising a mark located at the second end of the marking edge.

In particular, the method may comprise the following steps:
i) ready-made supplies of drug pockets each comprising at least two adjacent columns of a plurality of regions that follow each other in the position movement direction, wherein the columns extend parallel to the position movement direction Moving the ready-made supplies in the pockets in the direction of movement, wherein the marks are respectively arranged on a plurality of marked portions that follow each other in the columns that follow each other, or if applicable A medicament pocket comprising a mark disposed at a first end of the marking edge follows a medicament pocket comprising a mark disposed at the second end of the marking edge;
ii) separating the at least two columns from each other along at least one separation line following the position movement direction, each including a plurality of drug pockets following each other in the position movement direction; Elongate strips are formed with a number corresponding to the number of the columns;
iii) separating each individual drug pocket from each of the formed strips to separate each drug pocket contained in the strips; and
iv) Since each of the elongated strips is formed by laminating the individual drug pockets, the respective laminates are formed, and sequentially from one drug pocket to the next drug pocket. Each mark on the drug pocket is located in a marking portion that follows each other, or if applicable, a drug pocket comprising a mark located at the first end of the marking edge. , Following a drug pocket comprising a mark located at the second end of the marking edge.

  This method according to the invention has the advantage that the production of the laminate is carried out with greater reliability compared to the prior art, since it is for a plurality of drugs to be combined to form a laminate. This is because the pockets are first held integrally with the elongated strip, and are only separated from each other by unitization immediately before the respective pockets for medicine are stacked on top of each other. This reduces the risk of errors in the order of each drug pocket in the laminate. As a result, the correct number of drug pockets in the laminate and their order can be more easily realized.

  In addition to this, based on the marks on the drug pocket, for example, the laminate can be manually or automatically turned over, so that it can be checked that the laminate has been made sufficiently, The order of the marks on the drug pockets following each other in the laminate is checked.

  The fact that each medication pocket is provided with a mark in a manner according to the present invention is that when using the laminate, the user determines whether he has already taken a medication dose at the time interval in question. It means having potential. As a result, the progress of medication wafers can be monitored with the help of marks on each medication pocket. Thus, in addition to the general check function, the mark envisions a further function of quickly assigning a specific drug wafer to a specific dosing period or dosing time.

  The ready-made supply of drug pockets for producing a stack of drug pockets that serve to store and provide drug wafers preferably intersects the longitudinal direction of the ready-made supply of drug pockets. Extending at least 2, preferably at least 4 and preferably at most 12 adjacent columns, such as 4, 8, 10, or 12, for example, a plurality of areas following each other Each of the drug pockets is created by singulation from the ready-made supplies. Preferably, each drug pocket has a mark in one portion of a predetermined number of portions disposed adjacently at the marking edge. Further, the marks on each drug pocket on the ready-made supplies of the drug pockets are deployed in such a manner that the marks on the drug pockets that follow each other in the column are arranged at the marked portions that follow each other. Is done. If applicable, in each column, a drug pocket comprising a mark arranged at the first end of the marking edge comprises a mark arranged at the second end of the marking edge. Follow your pocket.

  In a manner according to the invention, the ready-made supply of drug pockets is used to produce a stack of drug pockets that serve to store and provide drug wafers.

  In addition, the ready-made supplies of the drug pockets can also be used to manufacture dispensing devices that store and provide drug wafers. The device comprises i) preferably in each case seven marking parts at the marking edge and in each case one mark in one marking part of each marking part In addition, a stack of a plurality of drug pockets each including the drug wafer, and ii) a carrier on which seven timing display parts on which the marks are aligned are suitably arranged are provided.

  The ready-made supplies of the drug pockets are preferably in the form of thin bodies with regions corresponding to each drug pocket. In a preferred embodiment of the present invention, a single thin body is composed of six columns adjacent to each other, each of which includes a plurality of drug pockets that follow each other, and seven that follow each other in each column. With a drug pocket. Thus, depending on the preferred number of drug pockets, 28 per laminate, 4 thin bodies are required for the simultaneous production of 6 laminates.

  In an alternative preferred embodiment of the present invention, the ready-made supply of the drug pocket may be deployed, for example, in the form of a long strip, which is wound onto a reel (coil). Can be unwound in the direction of position movement for the above method. For example, one belt-like body is six adjacent columns extending in parallel to the position movement direction, and includes six adjacent columns including a plurality of regions that follow each other in the position movement direction with respect to the drug pocket. Be prepared.

  In a preferred embodiment of the method, on the ready-made supply of the drug pocket, seven marked parts are arranged on each marking edge of the drug pocket. Each mark is preferably arranged in the second drug pocket area. In this case, since the marks on the respective regions that follow each other in one column on the ready-made supply of the drug pocket are respectively arranged on the marked portions that follow each other, each mark is provided for every seven pieces. The position changes in order for each drug pocket, that is, in each case, changes from the first drug pocket to the seventh drug pocket. If the ready-made supplies of drug pockets contain more than 7 regions in each column, for example 14 regions, the order of marks following each other on each region following each other in one column is It starts again at the eighth drug pocket and reaches the fourteenth drug pocket, and so on. In other words, when viewed in the position movement direction, it is preferable that seven drug pockets that follow each other are arranged in each column on the ready-made supply of the drug pockets. As a result, after laminating each drug pocket as a single unit, multiple weekly laminates are obtained, and these are finally laminated to form a monthly laminate with 28 drug pockets. Can do.

  Such sizing of a laminate with multiple drug pockets is particularly suitable for contraception and hormone replacement therapy, in this case over several weeks, eg 4 weeks (28 days). This is because a single medicine dose must be taken. By including 28 drug pockets in one laminate, the user can run out of one laminate for such a cycle in each case.

  If each drug wafer is to be taken every day, in a preferred embodiment, the time display is a display for each day of the week or a display for calendar days, the latter being represented by a month number. . However, the display unit for each day of the week is suitable, and has an advantage that the repetition is performed more frequently than the display unit for the calendar day as compared with the display unit for calendar days. As a result, a time indicator can be more easily deployed on the carrier because it is only necessary to select an appropriate day of the week from the seven days of the first day. is there. Preferably, at the start of the stage of taking each drug wafer, a day of the week display, a calendar day display, or another time display is provided on the carrier.

  The ready-made supply of the drug pocket according to the present invention preferably comprises a drug wafer containing a drug for contraception or hormone replacement therapy. In a series of drug pockets, there are subgroup drug pockets that do not contain any drugs but contain, for example, placebos or drug wafers that contain different drugs than other drug wafers. obtain. For example, placebo can be present in all 25th to 28th of a series of drug wafers. This means that in the case of contraception where there is a period of time when you should not take the drug, there is the advantage that taking a habitable wafer does not have to be interrupted, because placebo is no active ingredient It is because it does not contain.

  For example, the separation of at least two adjacent columns on the ready-made supply of the drug pocket along the separation line following the direction of the position movement is preferably carried out by cutting. The unitization of each drug pocket included in each formed strip is preferably performed by cutting or punching. In particular embodiments of the present invention, the separation of the strips from each other and the singulation of the drug pockets from the strips can also be performed by punching in each case.

  If the ready-made supplies of the drug pockets still do not contain any openings to the drug pockets, these openings can be added to the ready-made supplies of the drug pockets before or after singulation, for example by punching. Or it can be introduced for each drug pocket.

  Once the laminate is completed by laminating a plurality of singulated drug pockets, the laminate can subsequently be placed on a carrier. The drug pocket can be connected to the carrier on the carrier by a connecting element. Alternatively, each drug pocket can be laminated on the carrier and connected by the connecting element while they are being laminated. In both cases, the laminate is provided with excellent stability by the carrier and can be handled more easily. Furthermore, each wafer is protected from physical influences by the carrier.

  For example, in each case, each drug pocket can be laminated onto a carrier to create each first partial laminate. This allows a particularly reliable manner of manufacture, and each drug pocket is preferably held on a carrier for use by a user. As a result, the necessary stability can be achieved on the one hand, including the protection of the drug wafer from physical damage, and on the other hand, a time indicator can be deployed on the carrier which helps the user monitor regular dosing on the other hand. . Depending on the carrier, each drug pocket can also be combined and held within the laminate. The fact that each drug pocket of the first partial laminate is already laminated on the carrier means that they can be more easily combined and held. Thereby, in order to allow the laminated body to be fixed integrally with the carrier, an operation required in other cases of moving the completed laminated body to the carrier is omitted. .

  Each individual drug pocket can be directly laminated on a carrier. In this case, the carrier can already comprise the connecting element or a part of the connecting element. This achieves the effect that the laminate produced is already physically bonded and no longer decomposes during subsequent handling. This enables a highly reliable manufacturing mode. As far as the first modified embodiment of the present invention is concerned, after the production of the first partial laminate, further pockets for medication are laminated on the first partial laminate, so that the further agent The service pocket is likewise held by the connecting element. As far as the second modified embodiment of the present invention is concerned, each of the additional partial laminates, i.e., the second, third, fourth partial laminates, etc. is also included in each additional partial laminate. The contained drug pocket can be laminated onto the first partial laminate in such a way that it is similarly retained by the connecting element. Since this approach achieves an immediate fixation of the individual drug pockets, for example during position movement operations, partial or finished laminate disassembly can no longer occur.

  Each medicament pocket also preferably has an opening aligned with each other through which the connecting element can be directed. As a result, each medication pocket is connected to each other and is preferably arranged movably with respect to each other. This has the advantage of compensating for the slight height increase of the drug pocket caused by the drug wafer in the drug pocket. This allows the drug pockets to be positioned relative to each other in an orderly manner in the laminate. In this way, an aesthetically pleasing device is created on the one hand. On the other hand, each wafer in the stack is carefully stored because it is subject to a minimal physical load.

  In a further embodiment of the invention, the carrier also has a guiding element for guiding the drug pocket on the carrier. This achieves the effect that the drug pockets on the carrier are stacked on top of each other with their edges substantially strictly flush and can remain in this way thereafter.

  For the manufacture of the laminate, it is preferable that each drug pocket is placed in a cassette and stacked on top of each other in the cassette. If a carrier is used, each drug pocket can be loaded onto it since it is first placed in each cassette.

  Preferably, each of the time display portions is arranged in such a manner that when the respective drug pockets are combined on the carrier, the marked portions on the respective drug pockets and the time display portions are respectively aligned. Deployed on top.

  In a preferred embodiment of the invention, the laminate may also be joined by connecting elements without the use of a carrier. In this case, each drug pocket can be connected to the connecting element instead of to the carrier when they are stacked on top of each other in the first production device. In addition, guide elements can also be used in this case, so that the respective drug pockets can be stacked on top of each other and their edges can be held together in a strictly flush manner. The stack of pockets held together by the connecting element can then be fastened replaceably to the carrier. For example, the carrier can be formed in such a manner that the laminate can be easily clamped to the carrier. This makes it possible for the carrier to be replenished by the laminate by allowing the laminate to be exchanged in the carrier. This allows for a more sophisticated design of the carrier because it is reused without being discarded even when each wafer is used up.

  The connecting element can be, for example, a rivet or other certain connecting element that holds the laminate in a manner that prevents manual operation. Since the connecting elements connect the drug pockets to each other, they are preferably arranged movably with respect to each other. In the case of rivets, the connecting element can in each case comprise two connecting element members in the form of rods, for example one can be fitted or screwed into the other or glued to each other. The connecting element can also be in the form of a rod. In a further embodiment of the invention, the connecting element may also be formed in a compact form of construction, in which case it consists of two parts, so that when it is assembled the above-mentioned in each medicament pocket It is possible to fill the opening substantially completely. The connecting element comprises in particular a lower part in the form of a box with ribs arranged to pass through the opening and another part that closes the lower part in the form of a box. The box-shaped lower part of the box-shaped connecting element further comprises a base plate and a wall disposed on the base plate and partially surrounding each drug pocket to guide them. The rib may be provided. In any case, the connecting element is understood to mean a component that is directed through an opening in each drug pocket to connect each drug pocket. As a result, the rivets and the ribs of the connecting element formed in a compact type configuration can be understood as connecting elements. In the case of the ribs, of course, in order to hold the laminate together, additional and appropriate holding devices at the leg and head of the rib are required. These additional holding devices can be realized, for example, by a box configuration comprising a lower part and an upper part in the form of a box. Alternatively, the leg and head of the rib may also be provided with leg and head members that are differently designed to hold the laminate together. The rib can also be formed as a rivet with two rivet heads in the form of ribs. When each connecting element member forming the at least one connecting element is assembled, these members can be engaged with each other and preferably cannot be released from each other unless they are destroyed, or they are They may be adhesively bonded or welded to each other, or connected to each other by some other connection technique. In all these cases, what is known as a tamper-proof occlusion body, i.e., an occlusion body that blocks manual operation, is relevant. It is particularly preferred if the connection of the at least two members forming the connection element is achieved by a geometric fit. A rivet is a connecting element comprising at least two members that are connected to each other by geometrical engagement by engaging each other, and having a suitable head form, arranged in the middle It shall be understood to mean a connecting element which can also be fastened together with a stack of drug pockets.

  The carrier is preferably made from cardboard, plastic or metal. Preferably, the carrier surrounds the pocket stack to protect individual drug pockets. For this purpose, the carrier can be formed as an elongated strip that is folded around the laminate. For example, a front tab that protrudes on one side of the elongated strip may be formed as a lid. Furthermore, the tab protruding on the other side of the strip may be formed as a cover, for example. For example, the cover and lid may be provided with a suitable closing means, for example as a hook-and-loop, pressure, magnet, insertion or rubber band closure, which closes the carrier around the laminate.

  The time indicator may be provided on the carrier or on the connecting element.

  The donating device that accommodates the laminate produced by the method according to the present invention preferably has an anti-counterfeit configuration. For this purpose, on the device one or more counterfeiting is allowed, for example additional printing with micro-characters, holograms, tilted images or other anti-counterfeiting specific structures, which allows checking of the authenticity of the device. A specific structure for prevention is deployed.

  For each drug pocket, a perforation is preferably introduced which serves to break the second drug pocket area of the drug pocket containing the drug wafer. The perforations can be introduced into the ready-made supply of the drug pocket, for example, only before or after the mark is provided on the ready-made supply of the drug pocket. According to the perforation, the drug wafer can be easily removed from the laminate, for example by tearing or removing the second drug pocket region from the laminate. The first drug pocket region remains in the remaining laminate after the second region is torn off.

  In a preferred embodiment of the invention, the perforations are not formed over the full width of the drug pocket, but are shortened overall and fused into slits at both ends. Each slit creates a notch effect that further facilitates removal of the second drug pocket region. The perforations can be introduced, for example, by a suitable punching tool.

  In a further preferred embodiment of the invention, prior to the laminating of the individualized drug pockets, an additional step, ie an edge notch in each case, is added to each drug pocket. In each laminate, each notch increases step by step for each drug pocket. Therefore, when viewed from above all the drug pockets, a stepped transition product of notches is generated in the laminate. In this way, the mark deployed on the drug pack is made visible. For this purpose, on each drug pocket in one laminate, at the edge as viewed in the direction of position movement, it can be gradually moved away by the introduction of the notches, for example colored double dots, smile marks, Graphic symbols are preferably deployed in the form of symbols such as company logos or horizontal bars. For example, the notch that can be punched out of the drug pocket during the manufacturing process is a graphic symbol on the drug pocket located below in the finished laminate and can be seen in the area of the notch Expose the overview of. These graphic symbols can already be printed on the ready-made supply of the drug pocket. Each notch, and each graphic symbol that can be seen through them, can be used during the production of the laminate because the manufacturing operator or a suitable monitoring device can easily check that the laminate is complete. It has the advantage that the number of drug pockets in the body can be easily checked.

  In a preferred embodiment of the present invention, the mark is disposed on one aluminum layer of the plurality of aluminum layers or one polyethylene terephthalate layer of the plurality of polyethylene terephthalate layers.

  Each figure described below contributes to a general understanding of the present invention. However, the figures are not to be understood as limiting and are intended merely to illustrate certain preferred embodiments without excluding other preferred embodiments.

Fig. 2 is a schematic diagram of a method sequence of a method according to the present invention. It is a figure which shows the layout of the thin body from which the pocket for medicine is acquired by punching from the said thin body. The example of a change of the thin body of FIG. 2 is shown. It is a perspective view of the laminated body manufactured from the ready-made supply of the pocket for medicines in the example concerning the present invention. FIG. 4a is a perspective view of various embodiments of a pocket booklet for a wafer containing a stack of pockets according to the present invention produced by the above method according to the present invention, in various assembly stages, and FIG. It is a figure which shows a connection element. It is a figure which shows the pocket booklet for wafers when opened. It is a figure which shows the pocket booklet for wafers when closed. It is a side view of the pocket booklet for wafers. It is a figure which shows the alternative Example provided with the rubber band which closes the pocket booklet for wafers. FIG. 6 shows an alternative embodiment with a tab for closing a pocket pocket book for wafers. It is a figure which shows the alternative Example provided with the magnet type obstruction | occlusion body. FIG. 5a is a perspective view in various assembly stages of a further embodiment of a wafer pocket booklet containing a stack of pockets according to the invention produced by the method according to the invention, FIG. It is a figure which shows the support | carrier before fastening. It is a figure which shows each of the said laminated body and the connection element provided with the guide member as it is. It is a figure which shows the said laminated body and connection element which were assembled and fastened similarly to FIG. 5b-1. It is a figure which shows the pocket booklet for wafers opened after connecting with respect to the said support | carrier. It is a figure which shows the pocket booklet body for wafers closed. FIG. 6a is a perspective view at various assembly stages of a further embodiment of a wafer pocket booklet containing a stack of pockets according to the invention produced by the method according to the invention, FIG. It is a figure which shows the support | carrier provided with the member. It is a figure which shows the pocket booklet for wafers opened completely or partially after making a laminated body into a predetermined position. It is a figure which shows the pocket booklet for wafers opened completely or partially after making a laminated body into a predetermined position. It is a figure which shows the pocket booklet body for wafers closed. FIG. 6b is a view similar to FIG. 6a, with a different arrangement of day strips. It is a side view of the further Example of the pocket booklet for wafers which accommodates the laminated body which concerns on this invention manufactured by the said method which concerns on this invention. It is a perspective view of the further Example of the pocket booklet for wafers which accommodates the laminated body which concerns on this invention manufactured by the said method based on this invention, and the pocket booklet for wafers has a step-shaped notch. .

  The same reference number in each figure represents the same element.

  In FIG. 1, the method sequence according to the present invention is schematically reproduced by a ready-made supply of medicines and production equipment used in the production of laminates. The elements shown may represent devices that can be used to carry out the above method. However, as long as it contributes to the object according to the present invention, apparatuses having other configurations may be employed.

  Each thin body 7 including drug pockets in the form of a plurality of regions is fed to the punching devices 26, 26 'in the modules 30, 30', 30 ". The number of modules depends on the stack of pockets. The total number of drug pockets 4 to be included and the number of areas for drug pockets in one column contained in one thin body, ie the number of drug pockets to be delivered to each module For example, if a total of 28 drug pockets are combined into one laminate, and there are 7 drug pockets in one column on one thin body For example, four modules must be deployed.

  In FIG. 2, an example of the layout of the thin body 7 is shown, and there are a total of 6 × 7 = 42 drug pockets on the same number of regions 5. Each region is arranged in a plurality of columns R and a plurality of rows S. In the above case, 6 columns and 7 rows are deployed. In FIG. 2, each column and each row are exemplarily shown by arrows. Each region arranged in one column on one thin body can be assigned to one stack. Regions in different columns can each be assigned to a different stack.

  In each region 5, a region range 8 ′ for opening and a marking portion 18 on the marking edge can be visually recognized for each region. In the marked portion, the mark 3 is provided by, for example, a printing process, so that it is easier for the user to monitor regular medication. The positions of the marks on the marking edges in the same row but in different columns are the same in each case, while the positions of the marks in the areas following each other in one column are tracked one after the other When viewed from the bottom, each mark is placed at the bottom, the second from the bottom, the third from the bottom, and so on.

  The six adjacent columns R represented by the seven regions 5 are first transferred from the elongated strip 9 to the six elongated strips 9 along the separation line 11 before each drug pocket is separated. And disconnected. The single strip in each case is then further processed by separating each individual drug pocket. Next, the individual drug pockets that are singulated in this way are stacked on top of each other to form, for example, a plurality of weekly laminates. Subsequently, a further thin sheet 7 is processed by the same processing. For example, six weekly laminates are created from one thin body. On the first six weekly laminates obtained from the first thin body 7, additional 21 drug pockets obtained from the further three thin bodies 7 are placed respectively. As a result, a total of six laminates each including 28 drug pockets are formed. The fact that each strip 9 is first preferably made and only after that the fact that each drug pocket is cut or separated by punching from each strip is for each drug belonging to one laminate. It means that the pockets are held together in the form of an elongated strip as long as possible. According to this manner of carrying out the above process, they are separated from the elongated strip 13 only immediately before the respective pockets for medicine are stacked on top of each other. As a result, since an error in sorting is avoided, the reliability in creating the laminate is improved.

  In FIG. 2a, a modification of the ready-made supply of drug pockets from FIG. 2 is shown. This ready-made supply 7 differs from that described above in that eight columns R, each of which is seven regions 5, are provided for the manufacture of a pocket for medicaments. Further, each area includes a punched oval opening 8, a perforation 12 in which the first drug pocket area and the second drug pocket area are connected to each other by the perforation 12, and a side cut in the perforation. And a notch 13. Furthermore, on both sides of the ready-made supply 7 in the longitudinal direction, there are protruding edges 14 in which continuous perforations 15 are arranged. These perforations 15 contribute to the movement of the ready-made feed 7, for example in the same manner as advancing the film. Each column R of the thin body 7 is arranged in parallel to the direction (arrow 10) in which the thin body is moved during the manufacture of the drug pocket.

  In the vicinity of the opening 8, in each region 5, the marked portion 18 and the mark 3 in the marked portion can be visually recognized. In one column R composed of seven regions 5 (circled numbers, see FIG. 2) that follow each other, the position of each mark 3 sequentially changes from region to region. On the other hand, the position of each mark 3 in one row S remains unchanged.

  The ready-made supply 7 from FIG. 2 a is different from the ready-made supply described above according to FIG. 2 in that eight columns R, each consisting of seven regions 5, are provided for the manufacture of the drug pocket. Different.

  According to FIG. 1, two such thin bodies 7 are fed to each of the modules 30, 30 ′, 30 ″ (see arrows in FIG. 1). In FIG. The thin area corresponding to the rows R and S is also shown schematically.

  Each thin body 7 is placed on the punching bases 27 and 27 ′ of the punching devices 26 and 26 ′ at the same time. Therefore, each drug pocket 4 is punched out in a manner corresponding to the bordering of the regions in FIGS. 2 and 2a. At the same time, the aperture 8 is also formed by punching. The punching table can be displaced in parallel in a manner corresponding to the arrow. As a result, a single thin body is positioned below the punching device and aligned if appropriate prior to punching, and out of the punching area after punching of each drug pocket ( 1). As a result, the already punched drug pocket and eventually the punched residue are also sequentially removed from the punching table, while a further thin sheet is already placed on the punching table. Can be done. For this purpose, the punching operation is performed in the front region of the punching table (lower region in FIG. 1), in which case the thin body is first introduced for punching and, for example, by applying a vacuum. Also fixed. After the punching, each punching table is displaced rearward (separated from the feeding unit of the thin body), so that each punched drug pocket can be removed from the punching table.

  Contributing to the removal of the individual drug pockets 4 is a special robot arm (not shown) which ensures that the individually picked drug pockets are picked up and moved reliably. And in order to ensure that it is mounted again reliably, the sensor is provided. Each of the drug pockets is placed in the cassettes 25, 25 ', 25 ", 25"', ... by the robot arm. There is a carrier for each pocket stack in each cassette before the first drug pocket is placed therein, which carrier includes rivets or other connection means. Each drug pocket is mounted on a respective carrier in such a way that a rivet is passed through the aperture 8. As a result, each medication pocket is retained and additionally guided. Even if the stack of formed pockets is handled improperly, they can no longer be easily disassembled.

  In each of the modules 30, 30 ′, 30 ″ there are twelve cassettes, so that one thin module 7 can be fed to one module at the same time. This is because the body contains six columns R of drug pockets, the thin bodies 7 fed to the individual modules are punched out at the same time. The punched pocket 4 is brought into each cassette at the same time.

  Once all the drug pockets 4 of each thin body 7 have been moved into the corresponding cassettes 25, 25 ', 25 ", 25"', ... in the modules 30, 30 ', 30 " In the above case, each first partial laminate in the first module 30 includes seven drug pockets.Second module 30 In ', a second partial laminate has already been produced by laminating seven drug pockets on the first partial laminate. As a result, there are already 14 second partial laminates. And so on.

  After each partial stack is completed, all the cassettes 25, 25 ', 25 ", 25"', ... of the modules 30, 30 ', 30 "are simultaneously displaced to the right. Each cassette of one module 30 then reaches the second module 30 ', each cassette of the second module 30' reaches the third module 30 ", and so on.

  The cassettes 25, 25 ′, 25 ″, 25 ″ ′,... Were displaced from one module 30, 30 ′, 30 ″ to the modules arranged side by side and then punched from each thin body 7. The medicine pocket 4 is placed in the cassettes 25, 25 ′, 25 ″, 25 ″ ′,... Of the modules 30, 30 ′, 30 ″. As a result, a first partial stack of drug pockets is formed in the first module 30. In the further module 30 ′, 30 ″, additional drug pockets are added to the already existing partial laminate, so in the above case in the second module 30 ′ there are 14 drug pockets. A partial laminate with pockets is formed, in the third module a partial laminate with 21 drug pockets is formed, and in the fourth module 30 ″ there are 28 drug pockets. A completed laminate is provided.

  After completion of the pocket stack in the fourth module 30 ″, each stack is removed, the rivet connection on the stack is closed, and the carrier strip is folded back to protect the stack.

  FIG. 3 shows a stack 100 of drug pockets 4, 4 ′, 4 ″, which is manufactured by a suitable process and serves to store and provide the wafer 2, each drug pocket being a stack of layers. Later, or already between the layers, they are connected to each other. Each drug pocket 4, 4 ', 4 "is adjacent to each other on the marking edge and at the marking edge. Of the predetermined number of marked portions 18 arranged in the same manner, the mark 3 in one marked portion (shown only on the drug pocket 4 located at the top). The drug pockets 4, 4 ′, 4 ″ have a second drug pocket area 11 and a first drug pocket area 10, each opening 8 being aligned with each other. The element 200 is pierced in. The connecting element 200 connects each drug pocket 4 to each other and displaces them relative to each other, the opening 8 being formed as an elongated hole and the connecting element 200. Since the first drug pocket region 10 and the second drug pocket region 11 are connected to each other by the perforation 12, the drug wafer 2 disposed in the second drug pocket region 11 is attached to the first drug pocket region 10 and the second drug pocket region 11. Separation from the first drug pocket region 10 is further facilitated by the perforation 12. In this case, the first drug pocket region 10 remains in the laminate 100.

  In FIG. 4, a further embodiment of a pocket pocket book for a wafer comprising a pocket stack 100 manufactured by the method according to the invention is shown in perspective view. The wafer pocket laminate 100 from FIG. 4 is formed in substantially the same manner as the wafer pocket booklet according to FIG. 3, but in contrast to FIG. It is not adjacent to the perforation 12 but on the opposite edge of the drug pocket region 11.

  The pocket laminate 100 includes a plurality of drug pockets 4, 4 ′, 4 ″ such as 28 pockets, and only the uppermost drug pocket 4 among them can be visually recognized. 4, 4 ′, 4 ″ have a second drug pocket region 11 and a first drug pocket region 10. In each case, each drug pocket contains a welded wafer 2. There are a plurality of marking portions 18 on the lower edge 17 which is the marking edge. A mark 3 is present on one of the marked portions. In the second medicine pocket located below (not visible) the medicine pocket on the upper side which can be visually recognized, this mark is the first marked portion where the mark on the uppermost medicine pocket is located. Is placed on the marked part located next to

  The first drug pocket region 10 and the second drug pocket region 11 are each connected to each other by a perforation 12, which is formed generally shorter than in FIG. 3, ie, the drug pocket 4 Instead of extending over the full width of 4 ′, 4 ″, it merges into slits 13, 13 ′ acting like notches at both ends. The separation of the second drug pocket region 11 from the region 10 has the effect of further facilitating the removal of the drug wafer 2. After the separation of the second drug pocket region 11, The first drug pocket region 10 remains in the wafer pocket booklet, and each drug pocket has openings aligned therewith, here in the form of elongated holes 8, through which. Te, rivet 200 penetrates in the booklet of the assembled state.

  In this embodiment, in contrast to that of FIG. 3, the drug pocket 4, 4 ′, 4 ″ comprises a lower connecting element part 210 and an upper connecting element part 220 that completely fill the opening 8 in the assembled state. Connected by a compact connecting element 200, which is formed as a rivet, above the pocket stack 100, a two-part rivet 200 is shown, the rivet comprising a lower part 210 and an upper part It has a portion 220. The lower portion passes through the elongated hole 8 from below and on the base plate 213, the outer surface of each rivet holder is the round end of the elongated hole. The columnar rivet holders 211 and 212 are fastened, spaced apart from each other in such a way that they are positioned unconstrained with respect to each other. Each of the drug pockets placed one after the other on the bed portion easily slides on the rivet with their respective elongated holes (enlarged view of the rivet holder 212). Once formed, the rivet is closed because the upper rivet portion 220 is pressed between each rivet holder in the form of a pillar, the upper rivet portion being shaped with respect to the lower rivet portion. For this purpose, both rivet sections have serrated sides that engage each other for this purpose, and once the rivet is closed, the pocket stack is There is no need to worry about the integrity of the laminate being interspersed between, and it can be handled without any problems, and the laminate of riveted pockets refills the carrier. In Figure 4d, the rivet is shown to be long such that each drug pocket has vertical play on the rivet, as a result of comparison with other areas. Thus, tolerances for differences in the thickness of the region of the wafer pocket relative to the pocket can be configured, and each drug pocket also slides over the rivet without any friction.

  In the manufacture of the laminate 100, the lower connecting element 210 is held, for example, by a holding device or by a carrier, if applicable, and a unitized drug pocket 4, 4 ', 4 "or completed. The laminated body 100 is placed on the lower connecting element portion 210 by the opening 8. Subsequently, the connecting element 200 is closed by placing the upper connecting element portion 220.

  For example, the lower rivet portion 210 is preferably fastened on the carrier strip 300. When creating a first partial laminate from a plurality of drug pockets 4, the carrier strip is preferably first cassette 25, 25 ', 25 ", 25"', ... with the lower rivet portion. It is placed inside (FIG. 1). Each drug pocket is then placed on the strip, and the lower rivet portion fastened on the carrier strip slides into the slot 8 of the pocket, while Guides the fixed pockets and on the other hand holds them.

  After all the drug pockets of the wafer pocket booklet are stacked on top of each other, the carrier strip 300 is provided with the day strip 350. The day strip is deployed in such a way that it is aligned with the marked portion 18 on the drug pocket 4, 4 ', 4 ". This allows the wafer 2 in the drug pocket 4 located at the top to be The user is allowed to specify which day of the week to take.

  The carrier strip 300 is then folded at both the upper and lower ends in such a manner that the upper end forms a cover 320 for the wafer pocket booklet. For example, information regarding the manufacturer and the name of the drug may be provided on the cover. The cover extends over substantially the entire area of the drug pocket 4. After folding, it is secured by an upper rivet portion 220 that is pressed between the post-like rivet holders 211, 212 of the lower rivet portion 210.

  Since the lower end of the carrier strip 300 is also folded back, it forms a lid 330 for the drug pocket 4. In FIG. 4c, the closed wafer pocket booklet can be seen. The lid 330 reaches above the cover 320. The two parts are connected to each other by a releasable closure. For example, hook-and-loop fasteners 410 and 420 may be provided on the inner side of the lid and the outer side of the cover. The hook-and-loop closure is shown in FIG. 4d. In FIG. 4g, a magnetic closure is shown. For this purpose, for example, the edge of the lid 330 is preferably provided with a metal strip over the entire width of the lid and on the edge area of the cover 320 as well. Is provided with magnetized metal strips over the entire width of the cover.

  FIG. 4 e shows an alternative embodiment of a wafer pocket booklet, in which a rubber band 430 is provided instead of a hook-and-loop closure or a magnetic closure, which is the lower part of the carrier 300. And the booklet is closed by being hooked onto the cover 320.

  FIG. 4 f shows a further embodiment of a wafer pocket booklet. In this case, a tab 440 formed by punching and bent downward is provided on the cover 320, and the tab is engaged with the elongated hole 450 in the lid 330 when the wafer pocket booklet is closed. Can match.

  In FIG. 5, a further embodiment of a wafer pocket booklet comprising a pocket stack 100 manufactured by the method according to the invention is shown in perspective view at various assembly stages.

  The pocket laminate 100 includes a plurality of drug pockets 4 such as, for example, 28 pockets, and only the uppermost drug pocket among them can be seen. The drug pocket includes a welded wafer 2. There are a plurality of marking portions 18 on the lower edge 17 which is the marking edge. A mark 3 is present on one of the marked portions. In the second medicine pocket located below (not visible) the medicine pocket on the upper side which can be visually recognized, this mark is the first marked portion where the mark on the uppermost medicine pocket is located. Is placed on the marked part located next to

  Each drug pocket 4 is notched at 13 and 13 ′ on both sides and has a perforation 12. Further, the drug pocket has a long hole 8 through which the rib 214 passes through in the assembled booklet.

  In FIG. 5 b-1, a two-piece fastening device 200 is shown above the pocket stack 100, which has a lower portion 210 and an upper portion 220. The lower portion comprises a rib 214 and a frame 215 both disposed on the base plate 213. The rib passes through the long hole 8 from below. The frame 215 borders the base plate on three sides and partially on the fourth side. In the absence of this frame, each drug pocket may reach beyond the connecting portion having the perforations. In addition, the frame tightly surrounds the upper (first) portion of the drug pocket and, as a result, acts as an outer guide for the drug pocket, so that each drug pocket has no play and no wafer pocket. It is securely fixed in the booklet. The upper part of the fastening device is formed by a plate 220 that can be fastened onto the lower part by geometric fitting or material bonding. In the case of connection by material bonding, the plate can be connected to the lower part, for example by ultrasonic welding. For connection by geometric fitting, for example, a notch is provided on one of the two members, and a protrusion is provided on the other of the two members.

  Once the fastening device 200 has been closed, the (tightened) pocket laminate 100 does not need to be feared that the integrity of the laminate is disturbed during handling and is handled without any problems. Can be broken.

  The lower part 210 of the fastening device 200 is preferably fastened on the carrier strip 300, for example by adhesive bonding. If a first partial laminate is created to create a drug pocket laminate, the carrier strip is preferably first of the following to create it from each drug pocket 4. Along with the side portion 210, it is placed in each cassette 25, 25 ′, 25 ″, 25 ″ ′,... (FIG. 1). Each drug pocket is then placed on this strip, and the ribs 214 of the lower portion 210 clamped on the carrier strip slide into the slot 8 in each pocket. Each drug pocket is held on the carrier strip by this rib and frame 215. Furthermore, the position of each drug pocket is thereby fixed strictly.

  After all the drug pockets of the wafer pocket booklet are stacked on top of each other, the carrier strip 300 is provided with the day strip 350. The day strip is deployed in such a way that it is aligned with the mark 3 on the drug pocket 4 in each case because it is aligned with the marking portion 18. This allows the user to specify which day of the week the medicine pocket wafer located at the top should be taken.

  The carrier strip 300 is then folded in such a manner that this end forms a lid 330 for the wafer pocket booklet. On the cover, for example, information about the manufacturer and the name of the drug can be deployed. In this case, the cover extends over substantially the entire area of the drug pocket.

  The upper end of the carrier strip 300 is not folded back. In this regard, the fastening device 200 forms a box that closes the wafer pocket booklet at the upper edge. In FIG. 5d, the wafer pocket booklet in the closed state can be seen. The lid 330 extends on the fastening device. The two members are connected to each other by a releasable closure. For example, on the inner part of the lid and on the outer part of the fastening device, for example, there are magnetic closures each having a metal strip on one side and a magnetized metal strip on the other side, respectively. Can be deployed. Each subelement of the magnetic closure may also be included within each component in a cover-up manner.

  In FIG. 6, a further embodiment of a wafer pocket booklet comprising a pocket stack 100 produced by the method according to the invention is shown in perspective view at various assembly stages.

  The pocket laminate 100 includes a plurality of drug pockets such as 28 pockets, and only the uppermost drug pocket 2 among them can be seen. The drug pocket includes a welded wafer 2. There are a plurality of marking portions 18 on the lower edge 17 which is the marking edge. A mark 3 is present on one of the marked portions. In the second medicine pocket located below (not visible) the medicine pocket on the upper side which can be visually recognized, this mark is the first marked portion where the mark on the uppermost medicine pocket is located. Is placed on the marked part located next to

  Each drug pocket 4 is notched at 13 and 13 ′ on both sides and has a perforation 12. Further, the drug pocket has a long hole 8 through which the rib 214 passes through in the assembled booklet.

  In FIG. 6 a, the fastening device 200 is shown on the carrier strip 300. The fastening device is formed in two parts, which has a lower part 210 and an upper part 220. The lower part includes a rib 214, a frame 215, and a base plate 213. The rib passes through the long hole 8 from below. The frame 215 sits on the edge of the base plate 213. The frame borders the base plate on three sides and partially on the fourth side. In the absence of this frame, each drug pocket 4 may reach beyond the connecting portion having the perforation. Further, since the frame tightly surrounds the upper (first) portion of the drug pocket, it guides the drug pocket so that each drug pocket is securely fixed in the wafer pocket booklet without play. The The upper part of the fastening device is formed by a plate 220 that can be fastened onto the lower part by geometric fitting or material bonding. This plate 220 is connected to the carrier strip 300 by, for example, material bonding (such as by adhesive bonding).

  The lower part 210 of the fastening device 200 is fastened to the carrier strip 300, for example by adhesive bonding. When creating a laminate from a plurality of drug pockets or a first partial laminate from a plurality of drug pockets 4, the carrier strip together with the lower portion 210 is preferably cassette 25, 25 ′, 25 ″, 25 ″ ′,... Are first placed or placed first (FIG. 1). Each drug pocket is then placed on these strips, and the ribs 214 in the lower part of the fastening device fastened on the carrier strips slide into the elongated holes 8 in each pocket. Move. Each drug pocket is held on the carrier strip by this rib and frame 215. Further, the position is strictly fixed by the frame.

  After all the drug pockets 4 of the wafer pocket booklet are stacked on top of each other, the carrier strip 300 is provided with the day strip 350. The day strips may be deployed both in the position shown in FIG. 6a and in the position shown in FIG. 6e. The day strips are deployed in such a way that they are aligned with the marked portions 18 on the medication pocket 4. This allows the user to specify which day of the week the medicine pocket wafer located at the top should be taken.

  The carrier strip 300 is then folded at the upper end in such a manner that this end forms a lid 320 for the wafer pocket booklet. For example, information regarding the manufacturer and the name of the drug may be provided on the cover. In this case, the cover extends over the entire area of the medicine pocket 4 and extends over the overhanging portion of the carrier at the lower end of the booklet.

  The lower end of the carrier strip 300 is folded in such a way that a block 340 is obtained. The cover 320 reaches on the block. The two parts are connected to each other by a releasable closure. For example, a magnetic closure may be provided on the inner side of the cover and on the outer side of the block.

  Once the connecting element is folded back and closed, the wafer pocket booklet is assembled.

  FIG. 7 shows a further embodiment of a wafer pocket booklet. As with the booklet from FIG. 5, the lid 330 of the carrier 300 is pulled from below onto the pocket stack 100 and covers it in the closed state. In contrast to the embodiment from FIG. 5, rivets are used as connecting elements 200. At the same time, the rivet cooperates with the corresponding opening in the lid to act as a closure for the wafer pocket booklet because the protruding portion of the rivet is inserted into the hole in the lid. This is because that.

  FIG. 8 is substantially similar to FIG. 4, but the drug pockets 4, 4 ′, 4 ″ each include an off-the-shelf supply of drug pockets to include a laminate 100 with an additional side cut 16 in each case. 1 shows a perspective view of a wafer pocket booklet manufactured from a product, each notch 16 having a drug pocket 4, 4 ′, 4 which the first and second drug pocket regions 10, 11 have in common. "In the drug pockets 4, 4 ', 4" which are arranged on the edge of each other and follow each other, each notch gradually increases from the top to the bottom of the laminate for each drug pocket. Thus, when viewed from above all the drug pockets 4, 4 ′, 4 ″ in the laminate 100, a stepped transition product of the notches 16 for each drug pocket is generated. Each notch 16, for example, punched out from each of the drug pockets 4, 4 ′, 4 ″ during the manufacturing process, is a graphic symbol 21 represented as a double dot and is located below in the laminate 100. An overview of the graphic symbols 21 each introduced in the region of the notch 16 on the drug pockets 4 ', 4 "is exposed.

  In this embodiment, the laminate 100 is disposed on the carrier 300. The laminate 100 and the carrier are connected to each other by three rivets 200, 200 ′, 200 ″. Optionally, only one rivet 200 ′ is connected to connect the laminate 100 to the carrier. Alternatively, for example, the connecting element according to Fig. 4 can also be used, on the drug pocket 4 located at the top, the mark 3 and the marked part 18 can be seen in the second drug pocket area 11.

  In this embodiment, the carrier 300 has a region 360 that projects beyond the lower edge of the second drug pocket region 11 and when the carrier is aligned with each marking portion 18 on this region. The display unit 350 (day of week strip), that is, the display unit of each day of the week is included here.

  The timing display unit 350 is provided, for example, by attaching an adhesive, and each of “Mo”, “Di”, “Mi”, “Do”, “Fr”, “Sa”, and “So” in German. Has a display of the day of the week. The strip is prepared in such a way that the first day of the week indicator appears on the far left. On the medicine pocket 4 located at the top, the first mark 3 is arranged in alignment with the display part of the day of the week “Mo”. The further marks 3 are not shown, because they are obscured by the drug pocket 4 located above them.

Claims (34)

  A method of manufacturing a stack (100) of a plurality of drug pockets (4, 4 ', 4 ") that serves to store and provide a drug wafer (2), the drug pocket (4, 4 ′, 4 ″) of each of a predetermined number of marking portions (18) arranged on the marking edge (17) and adjacent to each other at the marking edge (17). In the method having the mark (3) in one mark portion, at least one laminate (100) is formed by laminating each of the drug pockets (4, 4 ', 4 ") on each other. Thus, in the at least one laminate (100), there are a plurality of drug pockets (4, 4 ′, 4 ″) that follow each other, and the marks (3) of the plurality of drug pockets follow each other. Placed in the marked part (18) And, if applicable, a drug pocket (4, 4 ', 4 ") with a mark (3) arranged at a first end of the marking edge (17) for the marking A method comprising a laminating step following a drug pocket (4, 4 ', 4 ") comprising a mark (3) arranged at the second end of the edge (17). a) In the first manufacturing apparatus (30), the plurality of drug pockets (4, 4 ′, 4 ″) are stacked on top of each other to form at least one first partial stack, In each of the one-part laminates there are mutually following drug pockets (4, 4 ', 4 ") in which the marks (3) are arranged in the marked parts (18) that follow each other, and If applicable, a drug pocket (4, 4 ′, 4 ″) with a mark (3) arranged at the first end of the marking edge (17) is connected to the marking edge (17). A laminating step following the drug pocket (4, 4 ', 4 ") with the mark (3) arranged at the second end of
b) In the second production device (30 ′), a further plurality of drug pockets (4, 4 ′, 4 ″) are laminated on the at least one first partial laminate, and thus In each of the formed partial laminates, the marked portions (18) that follow each other have the following drug pockets (4, 4 ′, 4 ″) in which the marks (3) are arranged, and If applicable, a drug pocket (4, 4 ′, 4 ″) with a mark (3) arranged at the first end of the marking edge (17) is connected to the marking edge ( 17) a laminating step following a drug pocket (4, 4 ', 4 ") comprising a mark (3) arranged at the second end of 17);
c) If applicable, in a further production device (30 ″), for further drug use onto the at least one partial laminate produced in the second production device or the further production device (30 ′) Step b) is repeated at least once by laminating the pockets (4, 4 ', 4 ") and finally at least one laminating consisting of a plurality of drug pockets (4, 4', 4") Repetitive steps to form the body (100);
The method of claim 1, comprising: In the first manufacturing apparatus (30), a plurality of drug pockets (4, 4 ′, 4 ″) are stacked on top of each other to form a first partial laminate,
In the second manufacturing apparatus and the third manufacturing apparatus (30 ′), at least one drug pocket (4, 4 ′, 4 ″) is stacked on each pre-formed partial laminate. Two second partial laminates and a third partial laminate are respectively created; and
In the fourth manufacturing device (30 ″), at least one laminate (100) is obtained by laminating a plurality of additional drug pockets (4, 4 ′, 4 ″) on each third partial laminate. The method of claim 2, wherein the method is created. a) In the first manufacturing apparatus (30), a plurality of drug pockets (4, 4 ′, 4 ″) are stacked on top of each other to form at least one first partial laminate, and in each case In the further production device (30 ', 30 "), at least one further partial laminate is formed, so that each first partial laminate and the further partial laminate follow each other. The marking portion (18) has a following drug pocket (4, 4 ′, 4 ″) in which the mark (3) is arranged and, if applicable, the marking edge (17). A drug pocket (4, 4 ', 4 ") having a mark (3) arranged at the first end of the mark (3) is arranged at the second end of the marking edge (17). ) To follow the drug pocket (4, 4 ', 4 ") And the floor,
b) The at least one first partial laminate and the further partial laminate formed in step a) are stacked on top of each other to form at least one laminate of drug pockets (4, 4 ′, 4 ″). (100) is formed, in each laminate (100), the drug pockets (4, 4 ', 4 ″) and, if applicable, a drug pocket (4, 4 ′, 4 ″) with a mark (3) arranged at the first end of the marking edge (17), A laminating step following a drug pocket (4, 4 ′, 4 ″) comprising a mark (3) arranged at the second end of the marking edge (17);
The method of claim 1, comprising:   In each case, four partial laminates are stacked on top of each other so that in each case one laminate (100) consisting of a plurality of drug pockets (4, 4 ′, 4 ″) is formed. The method of claim 4, comprising forming.   7. Marking part (18) is arranged on said marking edge (17) of each drug pocket (4, 4 ′, 4 ″) according to claim 1. The method according to any one of the above.   7. In each case, seven drug pockets (4, 4 ′, 4 ″) are stacked on top of each other to form one first partial stack. The method as described in any one of.   8. In each case, at least two first partial laminates are produced simultaneously by overlapping a plurality of drug pockets (4, 4 ′, 4 ″) with each other. The method according to claim 1.   In each case, a plurality of drug pockets (4, 4 ′, 4 ″) are stacked on top of each other to create the partial stack in the cassette (25, 25 ′, 25 ″, 25 ″ ′). A method according to any one of claims 1 to 8, characterized in that:   A plurality of drug pockets (4, 4 ', 4 ") are stacked on top of each other to create each first partial laminate on the carrier (300) in each case 10. A method according to any one of claims 1-9. Said carrier (300) has at least one connecting element (200) holding said drug pocket (4, 4 ', 4 ") on said carrier (300); and
The further plurality of drug pockets (4, 4 ', 4 ") or a further partial stack of drug pockets (4, 4', 4") are on the first partial stack. Since it is laminated, the further plurality of drug pockets (4, 4 ′, 4 ″) or the drug pockets (4, 4 ′, 4 ″) included in the further partial laminate are provided. 11. The method according to claim 10, characterized in that it is held in the same way by the connecting element (200).   12. Method according to claim 11, characterized in that the carrier (300) also comprises a guiding element (215) for guiding the drug pocket (4, 4 ', 4 ") on the carrier (300).   13. A plurality of time display portions (350) are provided on the carrier (300), so that the time display portions (350) are aligned with the marking portions (18), respectively. The method as described in any one of.   14. The method according to claim 13, wherein each of the time display portions (350) is a display portion for each day of the week.   15. The drug pocket (4, 4 ', 4 ") is created by singulation of a drug pocket from a ready-made supply (7). the method of. i) a ready-made supply (7) of drug pockets comprising at least two adjacent columns (R) each consisting of a plurality of regions (5) from the ready-made supply; 4 ′, 4 ″) is a step of deploying ready-made supplies (7) of drug pockets formed by singulation, wherein the marks (3) follow each other in the column (R) A deployment stage each deployed on a plurality of marked portions (18) following each other in a region (5);
ii) separating the at least two columns (R) from each other along at least one separation line (11) separating each column (R), following each other in each column (R); A separation step in which each strip (9) including a plurality of drug pockets (4, 4 ′, 4 ″) is formed to correspond to the number of columns (R);
iii) By separating the individual drug pockets (4, 4 ', 4 ") from the respective elongated strips (9), the respective drug pockets contained in the elongated strips (9) (4, 4 ′, 4 ″)
iv) Since each of the elongated strips (9) is formed by laminating the individual drug pockets (4, 4 ', 4 ") to form each laminate (100), one drug pocket (4, 4 ′, 4 ″) to the next drug pocket (4, 4 ′, 4 ″) sequentially, the drug pocket (4, 4 ′, 4 ″) in each laminate (100) A laminating stage in which each of the above marks (3) are arranged in marked portions (18) that follow each other;
The method according to claim 1, comprising:   Step i) is a step of moving the ready-made supply (7) of the drug pocket in the position movement direction (22), wherein the at least two columns (R) are in the position movement direction (22). The regions (5) follow each other in the position movement direction, the separation line (11) follows the position movement direction (22), and the plurality of medicines 17. Method according to claim 16, characterized in that it further comprises a position movement step in which the working pockets (4, 4 ', 4 ") follow each other in the position movement direction (22).   18. A method according to any one of the preceding claims, characterized in that one laminate (100) comprises 28 drug pockets (4, 4 ', 4 "). The laminate (100) is arranged on a carrier (300) and connected to the carrier (300) by a connecting element (200), or
Each of the drug pockets (4, 4 ′, 4 ″) is stacked on the carrier (300) and is connected to the carrier (300) by the connecting element (200). The method according to any one of claims 1 to 18.   In each drug pocket (4, 4 ′, 4 ″), the second drug pocket region (11) of the drug pocket (4, 4 ′, 4 ″) including the drug wafer (2) is broken. 20. A method according to any one of the preceding claims, characterized in that a perforation (12) conducive to said is introduced.   21. Method according to claim 20, characterized in that the mark (3) is arranged in the second drug pocket area (11).   The method according to any one of claims 16 to 21, characterized in that the separating step of separating the at least two adjacent columns (R) is carried out by cutting.   The simplification step of unitizing the drug pocket (4, 4 ', 4 ") included in the formed strip (9) is performed by cutting or punching. Item 23. The method according to any one of Items 16 to 22.   24. Method according to any one of claims 16 to 23, characterized in that the ready-made supply (7) of the drug pocket is thin.   Each thin body (7) is a column (R) adjacent to each other, and includes six or eight columns (R) including the plurality of drug pockets (4, 4 ′, 4 ″) following each other. 25. Method according to claim 24, characterized in that in each column (R) seven drug pockets (4, 4 ', 4 ") follow each other.   Prior to the laminating of the individualized drug pockets (4, 4 ', 4 "), an edge notch (16) is added to each drug pocket (4, 4', 4") in each case. Since each notch (16) in each laminate (100) is gradually increased for each drug pocket (4, 4 ', 4 "), all the drug pockets are provided. 17. Viewed from above (4, 4 ′, 4 ″), the stack (100) is provided with a further stage in which a stepped transition of a notch (16) is generated. 26. The method according to any one of 1 to 25.   27. Method according to any one of claims 1 to 26, characterized in that the drug wafer (2) is designed for use for contraception or hormone replacement therapy. With a ready-made supply of drug pockets (7) for manufacturing a stack (100) of a plurality of drug pockets (4, 4 ', 4 ") that serve to store and provide drug wafers (2) There,
The ready-made supply of drug pockets (7) has at least two adjacent columns (R) with a plurality of drug pockets (4, 4 ', 4 ") following each other;
Each drug pocket (4, 4 ', 4 ") is marked (3) in one marking part of a predetermined number of marking parts (18) arranged adjacent to each other at the marking edge. And
The marks (3) are arranged in such a way that the marks (3) on the drug pockets (4, 4 ', 4 ") that follow each other in each column (R) are arranged in the marked portions (18) that follow each other. A ready-made supply (7) of drug pockets deployed on each drug pocket (4, 4 ', 4 ") on the ready-made supply (7) of the drug pocket.   29. Ready-made supply of drug pockets (7) according to claim 28, characterized in that seven marking parts (18) are arranged on each marking edge.   30. Ready-made supplies of drug pockets (7) according to claim 28 or 29, characterized in that seven drug pockets (4, 4 ', 4 ") are arranged in each column (R). .   31. Ready-made supply of drug pockets (7) according to any one of claims 28 to 30, characterized in that the drug wafer (2) contains a drug for contraception or hormone replacement therapy. .   32. The medicine pocket (4, 4 ', 4 ") additionally has a graphic symbol (21) at the edge in each case. Ready-made supplies of drug pockets (7).   33. A method according to any one of claims 28 to 32, for producing a stack (100) of a plurality of drug pockets (4, 4 ', 4 ") which serves to store and provide a drug wafer (2). Use of ready-made supplies (7) of drug pockets according to 1. A device for storing and providing a drug wafer (2),
i) a stack (100) of a plurality of drug pockets (4, 4 ', 4 ") each comprising seven marked portions (18) and each containing said drug wafer (2);
ii) Seven timing indicators (350) on which the respective marks (3) are aligned, and a carrier (300) disposed thereon,
34. Use of a ready-made supply (7) of drug pockets according to any one of claims 28 to 33 for the manufacture of a device.

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