CN102307554A

CN102307554A - Method for the production of a stack of medicament pouches used for storing and supplying medicament wafers, medicament pouch template for producing said stack, and use of the medicament pouch template

Info

Publication number: CN102307554A
Application number: CN2010800069030A
Authority: CN
Inventors: K·赖夏特; S·菲勒
Original assignee: Bayer Pharma AG
Current assignee: Bayer Pharma AG
Priority date: 2009-02-06
Filing date: 2010-02-03
Publication date: 2012-01-04
Also published as: IL213968A0; WO2010089091A1; AU2010211258A1; BRPI1008017A2; JP2012516726A; US20110289888A1; EP2393467A1; KR20110116156A; CA2751429A1

Abstract

Disclosed is a method for safely producing stacks (100) of medicament pouches (4, 4', 4") containing medicament wafers (2), each of said pouches having a mark (3) in one of several adjacent marking sections (18) on a marking edge (17). In said method, the medicament pouches (4, 4', 4") are stacked on top of each other to form at least one stack (100) of medicament pouches such that the medicament pouches (4, 4', 4") in the at least one stack are arranged in the order in which the marks (3) thereof are located in successive marking sections (18), and, if applicable, a medicament pouch (4, 4', 4") having a mark (3) located at a first end of the marking edge (17) is arranged after a medicament pouch (4, 4', 4") having a mark (3) located at a second end of the marking edge (17).

Description

Be used to store and preserve the medicinal bag stack of medicine lamellar body manufacturing approach, be used to make the prefabricated medicinal bag of stack and the purposes of prefabricated medicinal bag

Technical field

The present invention relates to the method that a kind of manufacturing is used to store and preserve the medicinal bag stack of medicine lamellar body, comprise and use prefabricated medicinal bag, and relate to and make the purposes that stack and manufacturing are used to store and preserve the device of medicine lamellar body.The medicine lamellar body comprises the medicine of layering form.Particularly, the medicine lamellar body can comprise the hormone medicine, is particularly useful for practising contraception or hormone replaces the medicine of treatment.

Prior art

The medicine lamellar body is the device that comprises the plate form of active medicinal matter, and active medicinal matter is included in the active ingredient carriers.For example the active substance in the lamellar body can be by per os ground (transmucosally), the mucosa of through port just, medication.Lamellar body be placed on above the tongue or below, active ingredient carriers dissolving simultaneously and therefore discharge active substance.Lamellar body by with wherein they be encapsulated in the plate the bag in form appear, with protect they be not subjected to machinery with other environmental effect, for example dampness.According to DE 101 59 746 B4; These bags can comprise at least one carrier plate and at least one top plate; At least the plate that has large surface area has two parallel side edges so, and plate or Web materials (lamellar body) are encapsulated between carrier plate and the top plate with airtight and fluid-tight mode.The device that is used to store and preserve the medicine lamellar body can comprised bag by in the plate that stacks.Natch, the medicine lamellar body also can be formed differently, and they must not comprise the plate of large surface area and the plate of small surface area, but for example comprises the plate of size.In order to make the device according to DE 101 59 746 B4, the bag in the described plate that comprises the medicine lamellar body is easy to be combined in the stack and is introduced into this device.The device that is used to store and preserve lamellar body described herein comprises shell; Its cut apart once at least and the lateral edges of the bag that in plate, stacks laterally inboard against it, the edge of carrier plate that projects into outside, relevant plate edge, top simultaneously is against the inboard of its front.The bag that in plate, stacks be pressed in by means of spring shell on inboard.The front of shell, upper area have the independent conveying that two slits are used for carrier plate and top plate, for lamellar body, can appear with the carrier plate or with the top plate.Spring has and remains in remaining bag in the plate near the slit together after the bag in removing plate and locate the effect that they are used for further removing.Be provided with the separating tool that is used for carrier of separating plate from the plate of top between the slit, uppermost carrier plate leans against on this instrument with the region in front that it is positioned at top plate leading edge.Can be used for medicinal bag is transported to enclosure round the transport element that axis of rotation rotates.

Device with the medicinal bag that can remove in succession has drawback: use the medicinal bag be removed to take whether lamellar body that the user of medicine lamellar body can not Supervisory Surveillance Program takes has been taken or adhib still in special time period.Therefore, possibly be easy to take two lamellar bodies rather than one, perhaps the user forgets fully and takes lamellar body.

On the one hand, use the device of this sealing, the user can not see how long the process (prescribed course) that he has removed what lamellar bodies or regulation must continue.In addition, a special shortcoming of this device is that owing to be case type design, the user can not see in fact whether this device comprised necessary all medicinal bags of treatment.That open this compact apparatus and be not expection and open and to make its destruction.

For taking the hormone medicine, other medicines too, it is very important in the process of regulation, taking medicine, for example, one day three times or once a day, mode (regime) is by doctor's regulation of treatment patient.Yet most medicines are only taken during the limited time period, for example till the situation of being treated is completely recovered.But, must continue to take medicine for a long time in addition.In these cases, the situation that medicine is not perhaps taken at official hour may take place not take.Like this, the effect of treatment is relatively taken a risk usually.Therefore, have the trial that much is used to monitor drug administration, especially regulate numerical value according to patient's monitoring certainly.

For the effect of medical treatment, the integrity that comprises the device of medicine lamellar body is basic prerequisite.Being used for practising contraception and being used for the situation that hormone replaces the medicine lamellar body of treatment in use is so more.For this reason, when manufacturing was used for the device of time dependent medicament administration, sizable effort spent on the quality assurance.In addition, certainly, the contingent thing of the also interesting monitoring of the user of these devices.

Take the time and the frequency of the active substance unit of tablet, coated tablet or similar type about monitoring; Prior art discloses known drug bubble-cap (medicament blister); Just be used to store the device of tablet, coated tablet or analog; Wherein tablet, coated tablet or analog are comprised in the bag that is stamped in first plate, and said plate be connected to sealing bag second, on the tearable plate.If taking the specific time that depends on of tablet for example indicates the indicator of each day in the week can be provided on second plate.

For example, in EP 0 166 763 B1, a kind of bubble-cap of arranging the tablet bag of embarking on journey that has is provided.In the manufacturing of bubble-cap; Bag is specified the sky of giving at least one calendar month clearly; Successive in addition integer number indicator is arranged at clear and definite relation near the bag; Make each bag and to have only a calendar day visually to identify out by one of the calendar month; And successive integer number indicator is set on the peelable zone in second plate; So that they can see from the rear side of second plate, and each zone can and have only a calendar day visually to identify out by one of the calendar month.This allows each bag by one of the calendar month and have only a calendar day to identify out from front side and rear side.Thereby taking observing that tablet and user comply with every day can be easier.

In addition; In EP0511726B1; A kind of device that is used for the tablet of receiving array layout has been described; Comprise following: blister package with predetermined area; Wherein have many tablets with selected array configurations; Be used to receive the container of blister package and calendar; It can align with the tablet array in the blister package; Every day, calendar was movably to locate first tablet in selected initial day and the tablet array; And be arranged at the indicator on the container; Has positioning recess near the blister package on the edge of and near first tablet, to indicate first tablet that to take.

In addition, DE 10 2,005 032 015 A1 disclose a kind of box body that is used to receive blister package, and it has first halfbody and is hinged to second halfbody on said first halfbody.First halfbody of box body is formed the bag that is used to receive blister package; And first hole in having exterior section and interior examination part and checking partly and second hole in the exterior section; Concretely, be after packing is received in the bag, to be used on the residing position of container of tablet of blister package first hole to align at least with second hole.Second halfbody of casing has compartment and the window that is used in the interior examination part of the zone of compartment at second halfbody of box body, showing each day in the week of the indicating device of each day that is used for receiving one week of indication.Window is configured such that they are assigned to the container row that are received in the blister package in the bag.

Yet these embodiment that are used for storing and preserve the device of drug unit relate to the tablet of blister package, and its manufacturing approach fundamentally is different from the manufacturing approach of the device that in medicinal bag, has the medicine lamellar body.

Although the daily distractibility of patient guarantees that for the patient offers help the other example that medicine is taken is in planned time, for example, be used to receive the device of drug packages, wherein single tablet removes by automatic record.Various suggestions in following, have been provided: DE 198 50 890A1 (being used for the medicine distributor of tablet or analog just) for this problem; DE 197 39 438 A1 and DE 195 16 076 A1 (being used for the solid form drug sample, just the packing of tablet or analog); DE 198 52 602 A1 (be used for night prompting medicine just the apparatus and method of taking of tablet or analog); DE 102 13 547 C1 (blister pack device); DE 41 34 237C1 (being used for writing down the device that pill removes from blister package); EP 0 191 168 A2 (be used to store and point out and take the medicine device of tablet or analog just); DE 198 36 100 A1 (being used to store the medicament reservoir device of tablet or analog just); DE 102 17 929 A1 (device that is used for dispense tablets); US 2004/0050746A1 (pill keeper and alarm set); WO 01/54646A2 (pill distributor) and DE 10 2,005 048 515 A1 (being used for solid drugs part allotter and uses thereof of tablet or analog just) with warning function.

Yet, be not used in taking of monitoring medicine lamellar body to guarantee that they are by the suggestion of safely use.For example be used for the confection of lamellar body form or the allotter of medicine from DE 101 59746 B4 cicada.Yet the shortcoming that this device has is the probability that any monitoring of user is not provided, and for example whether has followed the process of taking to the special time period regulation.Therefore, possibly be easy to take two lamellar bodies rather than one, perhaps the user forgets fully and takes lamellar body.Especially, for taking contraceptive, free of discontinuities or regularly to take medicine be particular importance very for a long time.In this case, the part that the user must take medicine every day to exactissima diligentia, without exception.Forget that a part can cause very big danger, also can cause very big danger at two parts of taking medicine on the same day.Because the user possibly forget that very particularly having under the situation of pressure, for this point, about related medicine, what have problem especially is to guarantee that they are taken safely in official hour section medicament part for oral administration.In addition, also need such device be provided certainly through zero defect operation and low-cost manufacture method.

For this reason; First purpose is to find a kind of device; The medicinal bag that comprises the medicine lamellar body is prepared to, and for the user, makes said user from this device, remove lamellar body and take them with the order that is provided and the time that should be taken with the interval of regulation and according to them.For this reason, this device must be constructed such that the user can monitor taking of the medicine lamellar body in certain period of time, stipulated.The device that is used to store and preserve the medicine lamellar body is intended to be configured to use every day in addition, and is intended to have required mechanical stability.The medicine lamellar body also should be stored reliably.

Another purpose is that administration form (form of administration) can be made through actual inerrancy manufacturing approach easily and simply and therefore at low cost, so that administration form has guaranteed that for the user lamellar body is reliably taken error-free.The low cost manufacturing of administration form also requires can produce at short notice many this administration forms.

Therefore, another object of the present invention is to be designed for the method for making stack, makes and in manufacture process, can check the integrity about the stack of medicinal bag number simply.Especially, faultless stacking is intended to become possibility, so that stack comprises neither also not many very little medicinal bag.In this way, reduced because the last inspection of the stack that the cost that defective work causes and being used for is generated or be used for the cost of quality assurance.

The method that another object of the present invention provides a kind of prefabricated medicinal bag and is used for being used to store and preserve from prefabricated medicinal bag manufacturing the medicinal bag stack of medicine lamellar body is utilized prefabricated medicinal bag to produce and is allowed the user in use to monitor the stack of the medicine lamellar body that has been removed.

Summary of the invention

The purposes that these and other objects stored and preserved the medicinal bag of medicine lamellar body through being used in the claim manufacturing approach, prefabricated medicinal bag and the prefabricated medicinal bag through claim of stack that is used for making this medicinal bag through claim of stack is used to make this medicinal bag stack has realized.The preferred embodiments of the present invention are clear and definite in the dependent claims.

The stack that the method according to this invention is used to make storage and preserves the medicinal bag of medicine lamellar body, each medicinal bag on mark boundaries, has mark respectively in of said mark boundaries place a plurality of mark parts disposed adjacent one another.

The medicinal bag of medicine lamellar body typically comprises base portion or bottom plate and top plate.The preferred bar shaped of carrying out through the lateral boundaries of the plate along the top connects, and the top plate can be connected, and for example binding agent is bonding or welding, to base portion or bottom plate, otherwise perhaps.In addition, in particularly preferred embodiment, in all cases, base portion or bottom plate and top plate can have the tab of unconnected projection each other respectively at least one lateral boundaries.Therefore this makes medicinal bag tear more easily and be opened more easily, is used to remove be included in its inner lamellar body, because these two plates can be caught at an easy rate.The medicine lamellar body preferably is encapsulated in airtight and fluid-tight mode between base portion or bottom plate and the top plate through engaging in the zone that forms.Because the bag in the mode of their this formation, plate can have very little height or only be positioned at the zone of lamellar body.

The dispenser device of storing and preserve the medicine lamellar body through made according to the method for the present invention being used to comprises the medicinal bag with medicine lamellar body of (bag) stack form.In order to make the user can monitor in certain period of time whether the medicine lamellar body has been taken or adhib still, particularly, time marker can be arranged in the device with the form that is parallel to the medicinal bag border.In addition; Mark is provided on each medicinal bag; So that the mark that is provided on the medicinal bag adjacent one another are in the stack aligns with time marker adjacent one another are respectively; And alternatively; In stack, the medicinal bag that has mark at first end of mark boundaries is being followed the medicinal bag that has mark at second end of mark boundaries.This situation about mentioning at last is applicable to that number is placed in the situation in the stack greater than the medicinal bag of the number of the mark part on each medicinal bag, and like this, the order of the mark adjacent one another are in the mark part repeats in stack.Therefore, mark is being followed medicinal bag adjacent one another are in (follow) stack, and still, as long as medicinal bag in the end has mark in a mark part, the next medicinal bag in the stack will have mark in first mark part so.The medicinal bag of the back in the stack has mark once more in mark part adjacent one another are.

In order to make the user reliably from monitoring, according to the present invention, in case stack has been received in the dispenser device that is used for storing and preserving lamellar body, the mark that is arranged on the mark boundaries promptly aligns with time marker.This makes the user can confirm whether lamellar body is removed in certain period of time.

But this stack must be made error-free.This be because; If from medicinal bag, lost and had two the same medicinal bags in single medicine bag or the stack; Mark in specific markers in the order of the medicinal bag in the stack part is lost or is occurred twice so; The user is hoodwinked; And possibly take wrong medicine; Just, the user possibly forget in the official hour section and takes lamellar body or possibly take two lamellar bodies rather than one.Therefore; The manufacturing approach of stack must be carried out error-free; To make stack; The medicinal bag that wherein has mark self stacks; Make the mark of medicinal bag adjacent one another are in the stack be arranged in same mark part adjacent one another are; Perhaps, alternatively, the medicinal bag that has mark at first end of mark boundaries is being followed the medicinal bag that has mark at second end of mark boundaries.

In addition, must guarantee that the production of stack can have high efficiency, just high circulation rate.

For this reason, following stack manufacturing approach according to the present invention is provided for the said purpose of realization:

Stack medicinal bag up and down to form at least one bag stack; So that in said at least one stack; Has medicinal bag adjacent one another are; Their mark is set in the mark part adjacent one another are; And alternatively, the medicinal bag that has a mark at first end of mark boundaries is being followed the medicinal bag that has mark at second end of mark boundaries.

In this instance of the application and other instance, to have mentioned and stack medicinal bag up and down or stack medicinal bag, this is meant a medicinal bag is put into another above medicinal bag, just, for example, the medicinal bag that overlays on the stack is positioned on the stack.

Especially can be used to store and preserve through stack made according to the method for the present invention and be used to practise contraception or hormone replaces the medicine lamellar body of treatment.

The prefabricated medicine of the stack that is used to make the medicinal bag of storing and preserve the medicine lamellar body also is provided Bag, medicinal bag can come out to form through singulation from prefabricated medicinal bag.

In all cases, be utilized on the mark boundaries of medicinal bag mark is provided, guaranteed that the user can monitor lamellar body in all cases whether in a certain official hour section, to be taken.Whether this mark that is positioned at the medicinal bag at top through inspection carries out with the time marker region alignment corresponding to the time period of being discussed.

The practical implementation of summary of the invention

In the variation of preferred first embodiment of the present invention, manufacturing approach comprises the steps:

A) stack medicinal bag up and down in first manufacturing installation, to form at least one first's stack; So that in each first's stack, have medicinal bag adjacent one another are; Their mark is arranged in mark part adjacent one another are; And randomly, the medicinal bag that has a mark at first end of mark boundaries second end that is adjacent to mark boundaries has the medicinal bag of mark;

B) in second manufacturing installation; Other medicinal bag is stacked on said at least one first's stack; So that in each the part stack that forms by this way; Has medicinal bag adjacent one another are; Their mark is arranged in mark part adjacent one another are; And randomly, the medicinal bag that has a mark at first end of mark boundaries second end that is adjacent to mark boundaries has the medicinal bag of mark;

C) randomly; Through in other manufacturing installation, repeatedly other medicinal bag is stacked second or another manufacturing installation on said at least one part stack of making; And repeat one-time process step b) at least, thereby finally form at least one stack of medicinal bag.

In the variation of this method; At least one first's stack is at first made in first manufacturing installation; And other medicinal bag is stacked in other manufacturing installation on said at least one first's stack; Above-mentioned meaning realized a kind of very effective manufacture; Exactly; Through following realization: when in other manufacturing installation, stacking other medicinal bag on said at least one first's stack, preferably in said first manufacturing installation, make at least one next first stack simultaneously.This allows the stack of production part simultaneously.This equally also is applicable to following situation:, but at first produce at least one second portion stack and still have other medicinal bag must stack on said at least one second portion stack also not through in second manufacturing installation, medicinal bag being stacked when creating on said at least one first's stack at least one complete bag stack.Exactly, medicinal bag is stacked in the 3rd manufacturing installation on said at least one second portion stack.Therefore said at least one the third part stack that produces or said at least one complete bag stack of therefore producing preferred again and said at least one first and at least one second portion stack create simultaneously, or the like.

Also have advantage ground, after producing each part stack, can check respectively whether the part stack is made error-free.This can refuse defective part stack from manufacture process before whole bag stack is accomplished.This has realized making other medicinal bag no longer to stack the effect on the defective part stack.Improve volume of production on the one hand, reduced defective work on the other hand.

Especially; In another preferred embodiment of the present invention; In first manufacturing installation, make first's stack through stacking medicinal bag up and down; Through other medicinal bag is stacked in the second and the 3rd manufacturing installation, make on each previous part stack that forms at least one second with the third part stack, and through other medicinal bag being stacked on each third part stack and in the 4th manufacturing installation at least one complete medicinal bag stack of manufacturing.

In another preferred embodiment of the present invention; Said at least one first's stack of in first manufacturing installation, making and created simultaneously by other medicinal bag being stacked the other part stack of in other manufacturing installation, making on said at least one first's stack; That is to say; Medicinal bag further being stacked on said at least one first's stack of in said other manufacturing installation, carrying out takes place with said at least one first's stack manufacturing in first manufacturing installation simultaneously; Certainly; Said at least one first's stack must at first create in first manufacturing installation; Other medicinal bag is transported to then in second manufacturing installation, so that can be stacked at least one second portion stack that forms medicinal bag above it or the stack that at least one is complete.Certainly; Above-mentionedly also be applicable to following situation: other medicinal bag is stacked on said at least one second portion stack in the 3rd manufacturing installation, so that said at least one third part stack can create with said at least one first and second part stack simultaneously.This order can be proceeded as required; Exactly; In the 4th manufacturing installation, make at least one the 4th part stack or make at least one complete medicinal bag stack; In the 5th manufacturing installation, make at least one the 5th part stack or make at least one complete medicinal bag stack, or the like.

In second variation of the present invention, said method comprises following processing step:

A) in first manufacturing installation, stack medicinal bag up and down to form at least one first's stack and in other manufacturing installation, to form at least one other part stack in all cases; So that in each first's stack and other part stack, have medicinal bag adjacent one another are; Their mark is arranged in mark part adjacent one another are; And randomly, the medicinal bag that has a mark at first end of mark boundaries second end that is adjacent to mark boundaries has the medicinal bag of mark;

B) overlay said at least one first's stack that processing step forms in a) and said other part stack up and down to form at least one complete medicinal bag stack; So that in each complete stack, have medicinal bag adjacent one another are; Their mark is arranged in mark part adjacent one another are; And randomly, the medicinal bag that has a mark at first end of mark boundaries second end that is adjacent to mark boundaries has the medicinal bag of mark.

In this second variation of the present invention; Method step in a) be formed in first manufacturing installation said at least one first's stack be formed at other part stack in the other manufacturing installation (second, third or the 4th part stack; Deng) stacked up and down to form the bag stack; In stack, to have medicinal bag adjacent one another are; Their mark is arranged in mark part adjacent one another are; And randomly, the medicinal bag that has a mark at first end of mark boundaries second end that is adjacent to mark boundaries has the medicinal bag of mark.

In the preferred embodiment of this second embodiment variation of the present invention, in all cases, four part stack are at first created and are stacked these four part stack then respectively up and down, thereby form complete bag stack in all cases.

In another preferred embodiment of this second variation of the present invention; Said at least one the first's stack that is formed in first manufacturing installation is created with the other part stack that is formed in the other manufacturing installation simultaneously; That is to say, stack medicinal bag respectively up and down and all take place simultaneously to form said at least one first's stack, said at least one second portion stack, said at least one third part stack, said at least one the 4th part stack or the like.

In the variation of this embodiment; In all cases; At first produce at least one part stack; And then through being stacked together up and down combines them with appropriate section stack (making in front respectively) with it; Thereby form at least one complete medicinal bag stack; The above-mentioned fact also allows, and in all cases, before forming whole bag stack, in manufacture process, refuses any defective part stack.Therefore, on the one hand, can reduce cost, because the amount of defective work has minimized.On the other hand, manufacture process has been accelerated, because otherwise the medicinal bag that will be included in the defective stack can be used to make flawless stack.

In another preferred embodiment of above-mentioned two variations of the present invention; In all cases; Make at least two first's stack simultaneously through stacking medicinal bag up and down; Make at least two second portion stack simultaneously; Make at least two third part stack simultaneously; Or the like (in first embodiment of the present invention variation; Through medicinal bag being stacked respectively on the part stack that has formed; Except that first's stack; And in second embodiment variation of the present invention; In all cases; Form corresponding part stack through stacking medicinal bag respectively up and down; First; Second; Third part stack etc. are put into them together through stacking up and down subsequently).For example, in all cases, make six or 12 first's stack simultaneously through stacking medicinal bag up and down.Through parallel transportation medicinal bag, this can occur in the first suitable manufacturing installation.Then, these six of making simultaneously or 12 first's stack are transferred to second manufacturing installation,, produce six or 12 second portion stack or six or 12 complete bag stack again simultaneously here.Perhaps these six or 12 first stack are by to be put into second manufacturing installation with six or 12 second portion stack corresponding to the mode of second embodiment variation together.Can continue this order as required; For example six in first variation of the present invention or 12 second portion stack are transferred to the 3rd manufacturing installation; And produce six or 12 third part stack or six or 12 complete bag stack through side by side other medicinal bag being stacked on said six or 12 second portion stack, perhaps said six or the third part stack of 12 second portion stack quilts in the 3rd manufacturing installation in second variation of the present invention is put into.

Through this program a kind of very effective and high speed manufacture is provided, because in manufacturing installation, generate the mass part stack simultaneously.Yet, for these two kinds of variations of the method, stack simultaneously and be interpreted as not only that medicinal bag stacks up and down and form corresponding part stack simultaneously, just, suppose that it is in " in the same circulation " perhaps " synchronously ".Stack simultaneously and will also be understood that to being meant that corresponding part stack is formed by approximate simultaneously.By this way, can make a bag stack very apace.Yet synchronous in this case stacking up and down is preferred.For this purpose, each manufacturing installation is supplied with a plurality of medicinal bags simultaneously, and these medicinal bags of supplying with are simultaneously synchronously stacked formation part stack up and down then.

In of the present invention another preferred embodiment relevant with two kinds of variations of the present invention, in all cases, medicinal bag is stacked up and down in box to form the part stack.For this purpose, at least one box is provided preferably, medicinal bag is placed in this box the inside and is stacked up and down afterwards.For example, six or 12 boxes can be provided, for example layout is embarked on journey or is arranged to conveyer belt.

In addition; For example; Box can be movable; Part stack will in box, forming is transported to another manufacturing installation; Wherein each part stack is put together with the mode and another part stack that make a variation corresponding to second embodiment of the present invention, and said another part stack is placed on the first's stack in the box.

Alternately, box also can be move they are transported to second manufacturing installation, wherein, first embodiment of the invention variation, other medicinal bag is stacked on first's stack.For example, first's stack can form through seven medicinal bags.In second manufacturing installation, seven medicinal bags are stacked on first's stack.Afterwards, the second portion stack that comprises 14 medicinal bags can be transferred to the 3rd manufacturing installation, and wherein, for example, seven medicinal bags are in addition stacked on the second portion stack.Afterwards, the third part stack that comprises 21 medicinal bags can be transferred to the 4th manufacturing installation, and wherein, for example, seven medicinal bags are in addition stacked on the third part stack.In principle, in all cases, this process can utilize the medicinal bag of any number in each manufacturing installation and the manufacturing installation of any number to carry out.For example, can produce bag stack in this way with 28 medicinal bags.

If the lamellar body that is included in the medicinal bag is used for hormone replacement treatment, a bag stack typically comprises 28 medicinal bags.These 28 medicinal bags; Under the situation of single-phase preparation (single-phase preparation), can comprise 28 identical medicine lamellar bodies; Perhaps in biphase preparation (two-phase preparation) if situation under because contraception can comprise 24 identical medicine lamellar bodies and have other four medicine lamellar bodies of placebo or different pharmaceutical, perhaps under the situation of biphase preparation, can comprise 21 identical medicine lamellar bodies and other seven medicine lamellar bodies equally with placebo or different pharmaceutical.Under the situation of biphase preparation, the medicinal bag that comprises the lamellar body with placebo or other medicines must insert when bag stacks when beginning or finishes.For this reason; The medicinal bag that comprises the lamellar body with placebo or other medicines preferably is engaged to together when beginning in independent manufacturing installation and forms stack, is stacked on the part stack of having made when perhaps in independent manufacturing installation, stacking EO.

In other embodiments of the invention, the bag stack for example also is used to the purposes of practising contraception, and also can comprise the medicinal bag that is different from 28 number, exactly, and 30 medicinal bags for example.In this case; Can in each manufacturing installation, add ten medicinal bags (perhaps ten medicinal bags are stacked up and down to form first's stack) on the part stack that has existed respectively; Perhaps can add seven medicinal bags (adding four times) respectively, and can in another manufacturing installation, add two other medicinal bags at last.

In another embodiment of the present invention; Be used as under the situation of contraceptive; Lamellar body can also be used for the known flexibility plan of taking (flexible taking regime); Wherein continuing at least 24 days and the first maximum 120 days flexibilities removes lamellar body during taking the stage, and wherein first flexibility is the interrupt phase that for example continues four days after taking the stage.In this case, the bag stack can also comprise for example 28 or 56 or 84 or 112 or 120 medicinal bags, or the medicinal bag of any other number.In this case, the scheme that stacks medicinal bag up and down according to the present invention is the basis with the number that is present in the medicinal bag in the stack respectively in a corresponding way.

In a preferred embodiment of the invention, seven mark parts can be positioned on the mark boundaries of each medicinal bag.These mark parts can be for example corresponding to each day in the week, and mark is provided on one of them mark part of medicinal bag.Dispenser device in the assembling that is used for storing and preserve the medicine lamellar body; Mark part can align with the corresponding time marker on the device; For example align with the indicator of each day in the week; So that the special indication of one some day in week of expression on the mark that is arranged in the mark part on the medicinal bag at stack top and the device is alignd; For example " Mo " with the expression Monday aligns; And therefore pointing out the lamellar body in this medicinal bag of user to take at which day, is Monday in this example.

Alternately, for example three mark parts corresponding to a day three times (morning, noon, evenings) also can be provided, and perhaps the mark part corresponding to the different numbers of the corresponding requirements of the frequency of taking medicine can be provided.

In addition, in all cases, for example seven medicinal bags can be stacked up and down and formed at least one first's stack.In first embodiment variation of the present invention; In all cases; Seven other medicinal bags are stacked forms the second portion stack on said at least one first's stack, seven other medicinal bags are stacked on said at least one second portion stack, or the like.In second embodiment of the present invention variation, in all cases, remove first's stack that manufacturing comprises seven medicinal bags, second, third part stack etc., stack corresponding part stack then up and down.

This program is to have advantage ground, especially when medicinal bag has corresponding to seven mark parts of seven days in the week.In this case, the lamellar body that the medicinal bag in the part stack was preferred for during the week is taken, in all cases, if took a lamellar body in one day.

In another preferred embodiment of first variation of the present invention, stack is made in four manufacturing installations, wherein, in all cases, stacks seven medicinal bags for each stack.In second variation of the present invention, in order to form whole stack through stacking medicinal bag respectively up and down, four part stack are made and they are brought together.If in all cases, lamellar body was taken once in one day, and in the part stack seven medicinal bags was arranged in all cases, and 28 lamellar bodies in 28 days, taking so are incorporated in the stack.

In another preferred embodiment of the present invention, through for example forming medicinal bag from the plate singulation from prefabricated medicinal bag.On this meaning, plate is understood that to be meant preferably orthogonal, plate-like form.Plate preferably is bonded together with stratified form by different materials, and comprises for example thin film or plastic plate, aluminium foil, paper or similar articles.For example, medicinal bag can preferably be placed in intermediary two-layer formation by the medicine lamellar body.In this case, layer can have following layer order: polyethylene/aluminum/polyethylene terephthalate, polyethylene layer are outside against medicine lamellar body and polyethylene terephthalate aspect respectively.

Plate it is also understood that the stripes that can for example be winding on the spool (coil) for being meant, just elongated plate.

For singulation, plate preferably is sent to the monomer manufacturing installation and is placed in below the singulation device.There, the monomer medicine bag is preferably side by side carried out singulation from plate.Then singulation product (medicinal bag and singulation residue) is transported to and removes the position.Therefrom, medicinal bag is removed in succession, for example by means of mechanical hand.Mechanical hand can be equipped with special sensor, is booked, transports and put into box to verify each medicinal bag.

Medicinal bag preferably comes out through punching press singulation from the plate.This is the low and accurate singulation technology of cost.Other singulation technology also is conceivable, for example cutting.

In another preferred embodiment of the present invention; Plate comprises the zone corresponding to medicinal bag; In all cases, medicinal bag and have the medicine lamellar body in all cases and have in all cases with the mark in the borderline respective markers of the respective regions of the rectangular layout part.In plate, the medicine lamellar body is sealed through being attached to the inside.In addition, except that mark, can also have the impression that for example allows medicine identification on the plate.Plate preferably comprises at least four row and maximum 12 column regions.For example, four row, eight row, ten row or 12 column regions can be provided.For example every row comprise seven or 14 zones.

In another preferred embodiment of the present invention, it is adjacent one another are that its mark is arranged in the respective column of zone on plate of mark part adjacent one another are.Therefore, can remove them from plate with the logical order that medicinal bag is stacked up and down in the part stack.Many row adjacent one another are preferably have identical with the adjacent area of other row respectively zone.The zone of many row is formed medicinal bag by singulation, and then, in all cases, medicinal bag is supplied to the different portions stack.

With mode according to the present invention, this method for optimizing comprises the steps:

I., prefabricated medicinal bag is provided; At least two adjacent columns of said prefabricated medicinal bag inclusion region; Medicinal bag is through being come out to form by face singulation from it; And mark is provided in the mark part adjacent one another are on the zone adjacent one another are in the row; Perhaps randomly, the medicinal bag that has a mark at first end of mark boundaries second end that is adjacent to mark boundaries has the medicinal bag of mark;

Ii. separate said at least two adjacent columns along at least one separator bar of split bar, the stripes that comprises the medicinal bag adjacent one another are in the row is formed with the mode corresponding to column number;

Iii. through separating each monomer medicine bag from stripes, singulation is included in the medicinal bag in the stripes of corresponding formation; And

Iv. the medicinal bag of singulation that stacks corresponding stripes is to form corresponding stack; Like this; In each stack; From a medicinal bag to next medicinal bag little by little; Respective token on the medicinal bag is set in the mark part adjacent one another are; Perhaps randomly, the medicinal bag that has a mark at first end of mark boundaries second end that is adjacent to mark boundaries has the medicinal bag of mark.

Particularly, this method can comprise following processing step:

I. on transporting direction, transport prefabricated medicinal bag; Said prefabricated medicinal bag comprises the zone of at least two adjacent columns adjacent one another are on transporting direction; Said row are parallel to said transporting direction and extend; And mark is provided on the mark part adjacent one another are in the zone row adjacent one another are; Perhaps randomly, the medicinal bag that has a mark at first end of mark boundaries second end that is adjacent to mark boundaries has the medicinal bag of mark.

Ii. separate said at least two adjacent columns along at least one separator bar of following transporting direction, the stripes that is included in medicinal bag adjacent one another are on the transporting direction is formed with the mode corresponding to column number;

The method according to this invention has the advantage that is better than prior art; Be; The manufacturing of stack has higher reliability; Because the medicinal bag of combined formation stack at first is held togather in stripes, and only separated from each other through direct singulation before they self stack.This has reduced the danger that the medicinal bag in the stack makes a mistake in proper order.Therefore, the correct number of medicinal bag and their orders in stack can realize more easily.

Whether in addition, can be made satisfactorily according to the mark on medicinal bag inspection stack, for example stack is by the order of the mark of medicinal bag adjacent one another are in manually or automatically automatic page turning and the inspection stack.

Medicinal bag is provided mark to be meant that the user is using stack to confirm he has probability when whether in the time period of being discussed, having taken drug moiety with mode according to the present invention.Therefore, the progress of taking the medicine lamellar body can be monitored by means of the mark on the medicinal bag.Therefore, except that general audit function, mark demonstrates specifies another function of giving specific Time of Administration section or Time of Administration fast with the certain drugs lamellar body.

The prefabricated medicinal bag that is used to make storage and preserve the medicinal bag stack of medicine lamellar body comprises at least two; Preferably at least four and preferred maximum 12; For example four, eight, ten or 12 adjacent columns, said row preferred vertical in medicinal bag from it the longitudinal direction of the said prefabricated medicinal bag in the zone adjacent one another are that forms through singulation of face extend.Preferably, each medicinal bag has mark respectively in of mark boundaries place a plurality of parts disposed adjacent one another.In addition, mark is preferably provided on each medicinal bag of said prefabricated medicinal bag, and the mark on the medicinal bag adjacent one another are in the feasible row is provided in the mark part adjacent one another are.Alternatively, the medicinal bag that has a mark at first end of mark boundaries second end that is adjacent to mark boundaries has the medicinal bag of mark.

With mode according to the present invention, the stack that prefabricated medicinal bag is used to make storage and preserves the medicinal bag of medicine lamellar body.

In addition, prefabricated medicinal bag can also be used to make the dispenser device of storage and preservation medicine lamellar body.This device comprises i) comprise the stack of the medicinal bag of medicine lamellar body; Preferably; Said medicinal bag preferably has seven mark parts in all cases and has a mark in a mark part therein in all cases at the mark boundaries place; And ii) carrier, preferred cloth is equipped with seven time markeies that align with mark in the above.

Prefabricated medicinal bag preferably has the plate form corresponding to the zone of medicinal bag therein.In a preferred embodiment of the invention, plate comprises six row adjacent one another are of medicinal bag adjacent one another are, and has seven medicinal bags adjacent one another are in every row.Each stack preferably has 28 medicinal bags, and therefore, making six stack simultaneously needs four plates.

In alternative preferred embodiment of the present invention, prefabricated medicinal bag can also for example be provided as the form of strip portion, and stripes can be winding to spool (coil) and upward and then on transporting direction, launch to be used for the method.For example, stripes is included in six adjacent columns in zone adjacent one another are on the transporting direction of medicinal bag, and said row are parallel to transporting direction and extend.

In the preferred embodiment of this method, on prefabricated medicinal bag, on each mark boundaries of medicinal bag, have seven mark parts.Mark is preferably placed in second medicinal bag zone.In this case; Mark in the zone adjacent one another are in the row of prefabricated medicinal bag is provided in the mark part adjacent one another are; So that the position of mark in 7 sequence, promptly in all cases from first medicinal bag to the, seven medicinal bags, gradually changes from medicinal bag to medicinal bag.If comprise in every row of prefabricated medicinal bag more than seven zones, for example, comprise 14 zones, the sequence of the mark adjacent one another are on the zone adjacent one another are in the row starts anew from 14 medicinal bags of the 8th medicinal bag to the again so, or the like.In other words, look up in transporter, preferably, seven medicinal bags adjacent one another are are arranged in each row on the prefabricated medicinal bag.Therefore, singulation and stacking after the medicinal bag promptly obtains stack weekly, thereby and these can stack at last to form and have every month stack of 28 medicinal bags.

The size that stack with medicinal bag is set like this has advantage, during especially for contraception or hormone replacement treatment, because drug moiety must be taken once lasting several weeks in one day in this case, for example, four week (28 days).Through in stack, comprising 28 medicinal bags, the user can use up a stack in all cases as one-period.

If the medicine lamellar body is taken every day, in a preferred embodiment, time marker is the indication of each day in the week or the indication in calendar day, and the latter is through representing numbering every day of the moon.The indication of each day is preferably in one week, and has the advantage that is better than the calendar day indication, is that the indication of each day in the week repeats than the calendar day indication more continually.This makes time marker be provided on the carrier more easily, because for first day, only need to select seven days from a week suitable day of this week.In one week the indication in the indication of each day, calendar day or At All Other Times indicator preferably be provided on the carrier when beginning taking the medicine lamellar body stage.

Prefabricated medicinal bag according to the present invention preferably comprises the medicine lamellar body with contraception or hormone replacement medicine.The child group that in the row of medicinal bag, has medicinal bag wherein has following medicine lamellar body: except for example placebo (placebos), do not comprise any medicine, perhaps comprise the medicine that is different from other medicines lamellar body (two-phase medicine).For example can have placebo in each 25-the 28th medicinal bag in the row of medicine lamellar body.Be to have advantage ground being used under the situation of contraceptive this for example, wherein have the time period that should not take medicine, the lamellar body that convention is taken needn't interrupt, because placebo does not comprise any active substance.

At least two adjacent columns along the separator bar said prefabricated medicinal bag separated from each other of for example following transporting direction are preferably carried out through cutting.The medicinal bag that singulation is included in the stripes of formation preferably carries out through cutting or punching press.In specific embodiments of the present invention, in all cases, stripes separated from each other and on the stripes the singulation medicinal bag also can carry out through punching press.

If prefabricated medicinal bag does not comprise any opening that is used for medicinal bag, they can for example be introduced in prefabricated medicinal bag or the medicinal bag before or after singulation through punching press.

In case stack is accomplished through the medicinal bag that stacks singulation, stack can be arranged on the carrier subsequently.Medicinal bag can be connected on the carrier through Connection Element.Perhaps medicinal bag can be stacked on the carrier and when they are stacked and connected them through Connection Element.Under both of these case, through carrier, stack is provided with the stability of raising and can be handled more easily.In addition, lamellar body is not subjected to the influence of machinery by the carrier protection.

For example, in all cases, medicinal bag can be overlayed forms corresponding first stack on the carrier.This can obtain manufacture especially reliably: medicinal bag is preferably remained in the carrier by the user and uses.Therefore, on the one hand obtained required reliability, comprised that protection medicine lamellar body is not subjected to mechanical influence, and be used for supervisory user on the other hand and regularly take the time marker of medicine and can be provided in carrier.By means of carrier, medicinal bag also can be combined and be remained in the carrier.The medicinal bag of first's stack has been stacked means on the carrier that they can more easily combined and maintenance.This has exempted other necessary operation that the stack that will accomplish is transported to carrier and has been fixed together to allow stack and carrier.

The medicinal bag of singulation directly can be stacked on the carrier.In this case, carrier can also comprise Connection Element or part Connection Element.This has realized that formed stack is by mechanical bond and the effect that in processing procedure subsequently, can no longer scatter.This can a kind ofly obtain reliable manufacture.As for considering first embodiment variation of the present invention, after making first's stack, other medicinal bag is stacked on first's stack, so that other medicinal bag is also kept by Connection Element.As for considering second embodiment variation of the present invention; The part stack that each is other; Just; Second, third, the 4th part stack etc. also can be stacked on first's stack, makes the medicinal bag that is included in the said other part stack also kept by Connection Element.This program has realized the fixing at once of single medicinal bag, so that part stack or scattering of finally building up are for example no longer taken place in transport operation.

Medicinal bag also allows to have and is in alignment with each other and Connection Element is guided the opening that passes.Therefore, medicinal bag is connected to each other and is preferably relative to each other arranged movably simultaneously.This has the advantage of the low height in the medicinal bag that compensation medicine lamellar body causes in medicinal bag.This allows medicinal bag to arrange up and down in stack with mode in good order.In this way, on the one hand, obtained the device of aesthetic pleasant.On the other hand, the lamellar body in the stack bears minimum mechanical load and is therefore stored carefully.

In another embodiment of the present invention, carrier also has and is used for medicinal bag is directed into the guide element on the carrier.This fully accurate effect of aliging and can keep this mode in the back in edge of having realized that thereby the medicinal bag on the carrier self is stacked makes them.

Manufacturing for stack has advantage ground, if medicinal bag is placed in the box and in said box, self stacks respectively.If the use carrier, it at first is placed in the corresponding box, so that medicinal bag can be positioned over above it.

Time marker is preferably provided on the carrier, so that they align with mark part on the medicinal bag when medicinal bag combines with carrier.

In a preferred embodiment of the invention, when not using carrier, stack can also be combined by means of Connection Element.In this case, when medicinal bag self stacked in first manufacturing installation, they can be connected to Connection Element rather than be connected to carrier.In addition, can also use guide element in this case, with can self stack medicinal bag and so that their edge accurately the mode of alignment hold them in together.The bag stack that is held in together by means of Connection Element can be fastened on the carrier convertibly.For example, carrier can be formed stack and can be easy to fastening mode thereon.This can make stack commutative in carrier, and therefore allows carrier with stack filling again.This makes the more somewhat complex design of carrier become possibility, because carrier does not abandon after lamellar body is used up but reuses.

Connection Element can be for example rivet or a certain other Connection Element of stack being kept together with the form that prevents to operate.The Connection Element medicinal bag that is connected to each other is so that they are preferably relative to each other arranged movably.Under the situation of using rivet, in all cases, Connection Element can comprise two for example Connection Element parts of rod type, and they can be installed each other or be threaded togather or can combine with being bonded to each other.Connection Element also can be a rod type.In another embodiment of the present invention, Connection Element can also form the structure of compact, and wherein, it comprises two parts, when assembling it the time it can be in fact the opening in the filling medicinal bag fully.Particularly, Connection Element can comprise the lower part of box form, is provided with the rib that is used to pass opening within it, and another part of the lower part of enclosure form.In addition, the box form of the Connection Element of box form the lower part can comprise substrate, be positioned on the substrate and part encapsulated drug bag and therefore guide their wall, and rib.In any case Connection Element is to be appreciated that and is meant opening that is guided through in the medicinal bag and the parts that connect medicinal bag.Therefore, can be understood that Connection Element with the rivet of compact structure formation and the rib of Connection Element.If rib, foot and the head at rib needs other suitable holding device that stack is kept together certainly.These other holding devices can be through comprising box form lower part and the box structure on top realize, for example.Alternately, the foot of the different designs that stack is kept together and head part also can be provided in the foot and the head of rib.Rib can also be formed the rivet of the rivet head with two rib forms.When assembling forms the Connection Element part of said at least one Connection Element; These parts can be engaged with each other; And preferably do not destroy them and unclamp no longer each other, perhaps they can be combined bondingly or be soldered to go up each other or be connected to each other through a certain other interconnection technique.In all these situation, considered known tamperproof closing device (tamperproof closure), just, prevent the closing device of operating.Particularly preferably, said at least two parts that are connected to form Connection Element realize through the form cooperation.Rivet is interpreted as being meant the Connection Element that comprises at least two parts; These two parts are utilized form to cooperate to be engaged with each other and are therefore interconnected, and the stack that can will be arranged in the medicinal bag between them through having suitable head type is clamped together.

Carrier is preferably processed by cardboard, plastics or metal.Preferably, carrier pouch stack is to protect single medicinal bag.For this reason, carrier can be formed the elongated stripes that is folded back on the stack.For example, the preceding tab of stretching at a pleurapophysis of stripes can be formed lid.In addition, the tab in the opposite side projection of stripes for example can be formed lid.Lid and lid can for example be equipped with suitable closing device, surround the carrier of stack, for example shackle, pressure, Magnet, plug-in unit or rubber strap closing device with closure.

Time marker can be provided on the carrier or be provided on the Connection Element.

Comprise through the dispenser device of stack made according to the method for the present invention preferably false proof (forgery-proof) and dispose.For example, allow one or more anti-fake marks (security feature) of testing fixture verity to be provided on the device, for example, the impression of script, hologram (holograms), tilted image or other anti-fake mark.

Each medicinal bag is preferably introduced in the perforation in second medicinal bag zone of the medicinal bag that comprises the medicine lamellar body of being used to tear respectively.For example, perforation is introduced in the prefabricated medicinal bag before or after can be on mark is provided in it.Perforation makes the medicine lamellar body remove from stack at an easy rate, for example through tearing from stack or removing second area.Being torn the first medicinal bag zone, back at second area remains on the remaining stack.

In a preferred embodiment of the invention, perforation is not formed on the whole width of medicinal bag, but has totally been shortened, and incorporates in the slit at its two ends.Slit produces the recess effect, makes the second medicinal bag zone be removed more easily.Perforation can for example be introduced into through suitable stamping tool.

In another preferred embodiment of the present invention; Another step was provided before the medicinal bag that stacks singulation; Wherein, In all cases, medicinal bag is provided border excision portion in addition, and excision portion is increased from medicinal bag to medicinal bag in stack gradually; Like this; See from the top of all medicinal bags, in stack, form the successive excision portion of step shape, and make the mark that is provided on the drug packages visible by this way.For this reason, on each medicinal bag in stack, preferably at boundary pictorial symbolization being provided, looking up from transporter, for example is the form with symbol, for example painted two point, smiling face, Company Logo or whippletree, and they are removed through introducing excision portion gradually.For example can be in manufacture process show such image: the image of the stack of the completion of the pictorial symbolization on the medicinal bag below being arranged in the stack that the zone of excision portion, to see from the excision portion that medicinal bag stamps out.These pictorial symbolizations can be printed on the prefabricated medicinal bag.Excision portion and have such advantage: in the manufacture process of stack through the pictorial symbolization that they can be seen; Staff or the suitable supervising device made can check easily whether they are complete, and therefore can be easy to check the number of stack Chinese medicine bag.

In a preferred embodiment of the invention, this mark is provided on one of them aluminium lamination or one of them polyethylene terephthalate.

Description of drawings

The accompanying drawing that describes below is used for general understanding of the present invention.Yet they should not understood on being limited property ground, but only are intended to explain preferred specific embodiments, do not get rid of other preferred embodiment.

Fig. 1 shows the schematic statement of the processing step of the method according to this invention;

Fig. 2 shows the profile (layout) that makes the plate of medicinal bag through punching press;

Fig. 2 a shows the variation of the plate of Fig. 2;

Fig. 3 shows in an embodiment according to the present invention the perspective view of the stack that produces from prefabricated medicinal bag;

Fig. 4 with the form of perspective view show in the different phase that is in assembling comprise through bag stack made according to the method for the present invention lamellar body bag volume according to another embodiment of the present invention; Fig. 4 a shows bag stack and Connection Element; Fig. 4 b shows the lamellar body bag volume when opening; Lamellar body bag volume when Fig. 4 c shows closure; Fig. 4 d shows the side view of lamellar body bag volume; Fig. 4 e shows the alternate embodiments with the rubber strap (elastic tape, rubber strip) that is used to seal lamellar body bag volume; Fig. 4 border has gone out the alternate embodiments with the tab (tab) that is used to seal lamellar body bag volume; Fig. 4 g shows have the magnetic button alternate embodiments of (magnet closure);

Fig. 5 with the form of perspective view show in the different phase that is in assembling comprise through bag stack made according to the method for the present invention lamellar body bag volume according to another embodiment of the present invention; Fig. 5 a shows and clamps the preceding carrier (carrier) of stack; Fig. 5 b-1 shows stack and the Connection Element with guide member independently; Fig. 5 b-2 is similar to Fig. 5 b-1 and shows and be assembled and clamped stack and Connection Element; Fig. 5 c shows the lamellar body bag volume of opening after being connected on the carrier; Fig. 5 d shows closed lamellar body bag volume;

Fig. 6 with the form of perspective view show in the different phase that is in assembling comprise through lamellar body stack made according to the method for the present invention lamellar body bag volume according to another embodiment of the present invention; Fig. 6 a shows the carrier with Connection Element and guide member; Fig. 6 b and 6c show stack and are gone into the lamellar body bag volume of opening wholly or in part behind the position; Fig. 6 d shows the stack of closed lamellar body bag; Fig. 6 e is similar to the difference layout that Fig. 6 a shows the stripes of each day in one week of expression;

Fig. 7 shows the lamellar body bag volume that comprises through stack made according to the method for the present invention according to another embodiment of the present invention with the form of side view;

Fig. 8 shows the lamellar body bag volume that comprises through stack made according to the method for the present invention according to another embodiment of the present invention with the form of perspective view; Lamellar body bag volume has the excision portion of step shape.

The specific embodiment

Reference marker identical in the accompanying drawing is represented components identical.

In Fig. 1, processing step according to the present invention has carried out schematically duplicating to the medicine of ready-made supply and the manufacturing installation that in the process of making stack, uses.The element that is illustrated can be represented and can be used in the device of implementing this method.Yet, also can adopt other structure of employed device, if their are fit to the method according to this invention.

The plate 7 of the medicinal bag of inclusion region form be supplied to module 30,30 ', 30 " in decompressor 26,26 '.The number of module obtains based on following: be included in the sum of the medicinal bag 4 in bag stack, and be included in the regional number of medicinal bag in the row on the plate, just be supplied to the number of the medicinal bag of each module.As an example, if totally 28 medicinal bags are incorporated into and have seven medicinal bags in the row in the stack and on the plate, four modules must be provided then.

In Fig. 2, represented the example of the plane graph of plate 7, totally 6 * 7=42 medicinal bag is positioned on the zone 5 of similar number.These zones are arranged to be listed as R and row S.In this example, six row and seven row are provided.Row and column is represented through arrow as an example in Fig. 2.The zone that is arranged in the row on the plate can be assigned to stack.The zone of different lines can be assigned to different stack.

In zone 5, can see respectively the regional extent 8 that is used for the hole ' with the mark boundaries of respective regions on mark part 18.In mark part, for example mark 3 is provided through typography, make the user keep watch on regularly taking of medicine more easily.Can find out; In all cases; Different lines but the position of mark on the mark boundaries in the same lines is identical; But one after the other follow the position of the mark in the zone that in string, is closely adjacent to each other: from following beginning; In minimum, the third from the bottom minimum mark part minimum, second from the bottom that mark is set at, or the like.

With medicinal bag from stripes 9 before the singulation, six adjacent columns R that at first every row had seven zones 5 are cut into six stripes 9 along cut-off rule 11.In all cases, through splitting each monomeric medicinal bag, each stripes is further processed.Then, the medicinal bag of singulation is stacked by self respectively in this way, for example is used to form a week (weekly) stack.Subsequently, handle another plate 7 through identical method.For example, from a plate produce six the 1 week stack.Through will being placed into respectively from other 21 medicinal bags that three other plates 7 obtain on six the one week stack that obtain from first plate 7, six stack altogether that each stack comprises 28 medicinal bags have been formed.Preferably at first make stripes 9, downcut or through punching press separate drug bag from corresponding stripes then, mean that the form that the medicinal bag quilt that belongs to a stack is able to stripes as far as possible for a long time keeps together.According to the mode of this execution this method, only, just they are separated from stripes 9 medicinal bag before self being stacked.Therefore, avoided explode error, to improve the reliability that stack is made.

Represented the prefabricated medicinal bag variation of Fig. 2 among Fig. 2 a.This ready-made supply 7 is different from top description, and the eight row R in seven zones 5 of every row provided herein are used to make medicinal bag.In addition, each zone has avette opening 8, first medicinal bag zone and its perforation 12 connected to one another of the second medicinal bag zone passage that is stamped out, and the side direction recess 13 of perforation place.In addition, have the border 14 of projection in vertical both sides of ready-made supply 7, wherein have successive perforation 15.These perforation 15 are used to transport ready-made supply 7, for example identical with feeding film mode.The row R of plate 7 is configured to be parallel to the direction that plate betransported in the manufacture process of medicinal bag (arrow 10).

Can see the mark 3 in the mark part 18 adjacent and the mark part in 5 in the zone with opening 8.In the row R adjacent one another are of seven zones 5 (numeral of zone circle is with reference to figure 2), the position of mark 3 gradually changes from the zone to the zone.On the other hand, going the position of the mark 3 among the S remains unchanged.

Ready-made supply 7 differences among Fig. 2 a are described according to Fig. 2 in the above, and the eight row R in seven zones 5 of every row provided herein are used to make medicinal bag.

According to Fig. 1, module 30,30 ', 30 " each be supplied to two this plates 7 (with reference to the arrow among the figure 1).Corresponding to zone on the plate of single-row R and S be similar to Fig. 1 in schematically show.

Plate 7 by be put into simultaneously decompressor 26,26 ' punching press platform 27,27 ' on.Here, medicinal bag 4 by with Fig. 2 and 2a in zone boundary corresponding mode punching press come out.Simultaneously, hole 8 also forms through punching press.The punching press platform is can be parallel mobile corresponding to the mode of arrow.Therefore, plate can be placed in below the decompressor, and before punching press, aligns alternatively, and after stamping out medicinal bag, can be moved out of stamped area (in Fig. 1, making progress).Therefore, at the medicinal bag that has stamped out and last punching press residue still by adjoining land when the punching press platform is removed, possible another plate has been placed on the punching press platform.For this purpose, punching operation occurs in the front region interior (in the following zone among Fig. 1) of punching press platform, and the sheet material that wherein is used for punching press at first is placed and fixes, for example through using vacuum equipment.After the punching press, punching press platform (being supplied with away from plate) moves backward, so that the medicinal bag that stamps out can be removed from the punching press platform.

What be used to remove single medicinal bag 4 is special mechanical hand (not shown), its be equipped with pick off be used to guarantee by the single medicinal bag of picking up picked up reliably, transportation and placing reliably once more reliably.Use mechanical hand, medicinal bag be placed into box 25,25 ', 25 ", 25 " ' ... in.Before first medicinal bag is put into, in all cases, in box, have the carrier that is used for bag stack, said carrier comprises rivet or other connecting device.Medicinal bag is guided through hole 8 with rivet mode is placed on the corresponding carrier.So medicinal bag is held and is guided in addition.Handled inadequately even formed bag stack has carried out, they also can no longer easily scatter (fall apart).

Module 30,30 ', 30 " each in 12 boxes are arranged.Therefore, module can be supplied to two plates 7 respectively simultaneously, because each plate comprises six row R medicinal bags.The plate 7 that is supplied to individual module is stamped simultaneously.In addition, in each module, the bag 4 of the particular row S that is stamped out is brought in the box simultaneously.

Module 30,30 ', 30 " in all medicinal bags 4 of plate 7 be transported to corresponding box 25,25 ', 25 ", 25 " ' ... in after, part stack (part-stack) has produced there.In this example, each the first's stack in first module 30 comprises seven medicinal bags.Second module 30 ' in, produced the second portion stack on first's stack through seven medicinal bags are stacked.Therefore, the second portion stack has comprised 14 medicinal bags, or the like.

After accomplishing the part stack respectively, module 30,30 ', 30 " all boxes 25,25 ', 25 ", 25 " ' ... moved to the right side simultaneously.Therefore, the box of first module 30 arrive second module 30 ', second module 30 ' box arrive three module 30 ", or the like.

Box 25,25 ', 25 ", 25 " ' ... From a module 30,30 ', 30 " after moving to the module that is arranged side by side on its right side, the medicinal bag 4 that stamps out from plate 7 be placed to module 30,30 ', 30 " box 25,25 ', 25 ", 25 " ' ... In.Therefore, first's stack of medicinal bag is formed in first module 30.Other module 30 ', 30 " in; other medicinal bag is added on the part stack that has existed; thereby in this example; the part stack with 14 medicinal bags be formed on second module 30 ' in, the part stack with 21 medicinal bags is formed in the three module and last stack with 28 medicinal bags is formed at four module 30 " in.

At four module 30 " in accomplish the stacking of bag after, remove stack, the rivet on the closed stack connects, and the carrier bar that turns back is with the protection stack.

Fig. 3 show the

medicinal bag

4,4 that is used to store and preserve medicine lamellar body 2 through the method for optimizing manufacturing ', 4 " stack 100, after stacking or stacking process Chinese medicine bag, be connected to each other.Each

medicinal bag

4,4 ', 4 " on mark boundaries, have mark 3 respectively, each mark is located among of a plurality of mark parts 18 of mark boundaries place setting adjacent one another are (only on the medicinal bag 4 that is positioned at the top, having represented

).Medicinal bag

4,4 ', 4 " it is regional 10 to have second medicinal bag zone, 11 and first medicinal bag, and respective openings 8 is in alignment with each other.Connection Element 200 is guided through opening 8.Connection Element 200 is connected to each other medicinal bag 4 and makes them relative to each other removable.Opening 8 is formed slotted hole and Connection Element 200 is formed rivet.10 and second medicinal bag zone, first medicinal bag zone 11 is connected to each other via perforation 12, so that separate the medicine lamellar body 2 that is arranged in second medicinal bag zone 11 from first medicinal bag zone 10 more easily at perforation 12 places.In this case, first medicinal bag zone 10 is retained in the stack 100.

In Fig. 4, show another embodiment that comprises through the lamellar body bag volume of bag stack 100 made according to the method for the present invention with the form of perspective view.The stack 100 of the lamellar body bag of Fig. 4 is substantially to form with the identical mode of lamellar body bag volume according to Fig. 3, though compare with Fig. 3, mark 3 is not adjacent with perforation 12 with mark part 18, but on the opposite boundary in medicinal bag zone 11.

The stack 100 of bag comprise a plurality of

medicinal bags

4,4 ', 4 ", 28 bags for example are wherein only to see uppermost medicinal bag 4.

Medicinal bag

4,4 ', 4 " have second medicinal bag zone, 11 and first medicinal bag regional 10.In all cases, medicinal bag comprises the lamellar body 2 that is encapsulated in the inside (welded-in).Lower boundary 17 places on the border that serves as a mark have mark part 18.Has mark 3 on a mark part therein.Second medicinal bag (invisible) below the visible medicinal bag on be arranged in, this mark are set on the adjacent next mark part of first mark part at mark place of uppermost medicinal bag.

10 and second medicinal bag zone, first medicinal bag zone 11 12 is connected to each other via boring a hole; Perforation is formed the perforation that totally is shorter than among Fig. 3; That is to say, it does not extend

medicinal bag

4,4 ', 4 " whole width, but its two ends converge to the

slit

13,13 that is similar to notch effect ' in.Through pulling down second medicinal bag zone 11 from first medicinal bag zone 10 more easily, have and remove the effect of medicine lamellar body 2 down more easily at perforation 12 places.First medicinal bag zone 10 remains in the lamellar body bag volume after pulling down second medicinal bag zone 11.In addition, medicinal bag has the respective openings that is in alignment with each other, and here is the form of slotted hole 8, and rivet 200 or rib pass this opening in the confined state of lamellar body bag volume.

In the present embodiment; Compare with Fig. 3; Medicinal bag 4,4 ', 4 " through comprising that down the Connection Element 200 of Connection Element part 210 and the compactness of last Connection Element part 220 is connected, it is complete filling opening 8 under the state that assembles, and said Connection Element is formed rivet.Above bag stack 100, show two-piece rivets 200: rivet has lower part 210 and top 220.Slotted hole 8 is passed in the lower part from below.Column rivet keeper 211,212 is secured to substrate 213, so that the mode of leading nose circle of the lateral border of rivet keeper pine loose ground butt slotted hole is spaced apart from each other.These lateral borders are inclined upwardly slightly, so that the medicinal bag that is placed into down in succession on the rivet portion is easy to utilize corresponding slotted hole to slide into (rivet keeper 212 is exaggerated and has represented) on the rivet.After having formed whole bag stack, closed rivet just will be gone up rivet portion 220 and be pressed between the column rivet keeper.To go up rivet portion for the type of service cooperation and be connected to down rivet portion, two rivet portion have the zigzag side surface interlocked with one another that is provided with for this purpose.After the rivet closure, can handle the bag stack and have no problem, and needn't worry in processing, possibly damage the integrity of stack.In addition, the bag stack of being riveted can also be used for loading again carrier.Be equipped with at the rivet shown in Fig. 4 d and make medicinal bag have the length in vertical gap in the above.Therefore, can be shaped on tolerance to the thickness difference that the lamellar body bag zone on the bag is compared with other zone.The also slip of no any friction on rivet of medicinal bag.

In the manufacturing of stack 100, following Connection Element 210 for example is held device and keeps, perhaps kept by carrier alternatively, and by the

medicinal bag

4,4 of singulation ', 4 " or the stack of accomplishing 100 is positioned over down on the Connection Element part 210 via opening 8.Subsequently, the closed Connection Element 200 through placing Connection Element part 220.

For example, following rivet portion 210 preferably is secured on the carrier bar 300.When making first's stack by medicinal bag 4, preferably at first with the carrier bar with rivet portion down put into box 25,25 ', 25 ", 25 " ' ... Interior (Fig. 1).Then, medicinal bag is put on this, the following rivet portion that is secured on the carrier bar slips into respectively in the slotted hole 8 of bag, and the bag that guides its position to be fixed also maintains them on the other hand on the one hand.

Stacked up and down after all medicinal bags of lamellar body bag volume, carrier bar 300 is provided the stripes 350 of each day in one week of expression.The stripes of representing each day in the week be configured to make its with

medicinal bag

4,4 ', 4 " on 18 one-tenth lines of mark part on.Which day of a week this lamellar body 2 that allows User Recognition to be arranged in the medicinal bag 4 above it must be taken.

Then, the carrier bar 300 that turns back in top and bottom makes the upper end form the lid 320 of lamellar body bag volume.For example relevant with manufacturer and medicine name information can be provided in to cover.Lid extends the whole area of medicinal bag 4 substantially.After turning back, it is fixing that it is pressed into down column rivet keeper 211, the last rivet portion between 212 220 of rivet portion 210.

The lower end of carrier bar 300 of turning back equally is so that it forms the lid 330 of medicinal bag 4.In Fig. 4 c, can see the closure state of lamellar body bag volume.Lid 330 arrives and covers 320 tops.These two parts are connected to each other via releasable closing device (closure).For example, hook-loop fastener 410,420 can be set at the outside of the inboard and lid of lid.The shackle closing device has been shown in Fig. 4 d.The magnetic button has been shown in Fig. 4 g.For this purpose, for example, on lid 330 border, preferably on the whole width of lid, bonding jumper is provided, and for example, the bonding jumper that is magnetized is provided in and covers on 320 the borderline region, equally preferably is provided on the whole width of lid.

The alternate embodiments of lamellar body bag volume has been shown in Fig. 4 e: substitute shackle closing device or magnetic and buckle, rubber strap 430 is provided, said rubber strap is secured to the lower part of carrier 300 and is pulled to cover and is used for closed volume on 320.

Another embodiment of lamellar body bag volume has been shown in Fig. 4 f.In this example, the tab 440 that forms through punching press and downwarping is provided in and covers on 320, and when closed lamellar body bag volume, said tab can join in the slotted hole 450 that covers in 330.

In Fig. 5, show another embodiment that comprises in the different phase of assembling with the form of perspective view through the lamellar body bag volume of bag stack 100 made according to the method for the present invention.

Bag stack 100 comprises a plurality of medicinal bags 4, and for example, 28 bags are wherein only to see uppermost medicinal bag.Medicinal bag comprises the lamellar body 2 that is encapsulated in the inside.Lower boundary 17 places on the border that serves as a mark have mark part 18.Has mark 3 on a mark part therein.Second medicinal bag (invisible) below the visible medicinal bag on be arranged in, this labelling are provided in the tight adjacent mark part of residing first mark part of mark on the wherein uppermost medicinal bag.

Medicinal bag 4, on the both sides upper area 13,13 ' in, by being shaped on recess, and have perforation 12.In addition, medicinal bag has slotted hole 8, and confined state middle rib 214 on the regular payroll passes slotted hole 8.

Among Fig. 5 b-1, what above bag stack 100, illustrate is clamp device 200, and it is formed two parts: clamp device has lower part 210 and top 220.The lower part comprises the rib 214 and framework 215 that all is provided on the substrate 13.Rib passes slotted hole 8 from below.Framework 215 limits three sides and limits substrate in the 4th limit part.When lacking framework, medicinal bag can arrive the top, coupling part with perforation.And this framework is the going up (first) part and therefore represent the external guidance part of medicinal bag of encapsulated drug bag comfily, so that guide member is fixedly secured on lamellar body bag volume by gapless.The top of clamp device forms through plate 220, and it can utilize form to cooperate or material combines to be secured on the lower part.Under the situation that combines to connect at materials used, for example plate can be connected to the lower part by means of ultra-sonic welded.For the connection that utilizes form to cooperate, for example, excision portion is provided on one of them of this two parts and projection is provided on another of this two parts.

After clamp device 200 is closed, can handles and have no problem (clamped) bag stack 100, and needn't worry in processing procedure, possibly damage the integrity of stack.

The lower part 210 of clamp device 200 is preferred, and is for example bonding through binding agent, is secured to carrier bar 300.If in order to make the stack of medicinal bag, first's stack is created, then preferably at first with the carrier bar together with lower part 210 put into corresponding box 25,25 ', 25 ", 25 " ' ... (Fig. 1) be used for from medicinal bag 4 production stack.Then medicinal bag is placed on this, the rib 214 that is secured to the lower part 210 on the carrier bar slips in the slotted hole 8 of bag.Medicinal bag is remained on the carrier bar by this rib and framework 215.In addition, the position of medicinal bag therefore can be by accurately fixing.

Stacked up and down after all medicinal bags of lamellar body bag volume, carrier bar 300 is provided the stripes 350 of each day in one week of expression.The stripes of representing each day in the week is configured to make itself and mark part 18, and therefore in all cases with medicinal bag 4 on mark 3 align.Which day of a week this lamellar body that allows User Recognition to be arranged in the medicinal bag above it must be taken.

Then, the carrier bar 300 that turns back in the lower end is so that this end forms the lid 330 of lamellar body bag volume.For example relevant with manufacturer and medicine name information can be provided in to cover.Lid extends the whole area of medicinal bag substantially in this case.

Do not turn back in the upper end of carrier bar 300.In this, clamp device 200 is formed on the box body of place, coboundary sealing lamellar body bag volume.In Fig. 5 d, can see the closure state of lamellar body bag volume.Lid 330 extends above whole clamp device.These two parts are connected to each other through releasable closing device.For example, the magnetic button can be provided in the inboard of lid and the outside of clamp device, for example, provides bonding jumper that the bonding jumper that is magnetized is provided at opposite side in a side.The subelement of magnetic button also can be included in the corresponding component with the mode of hiding.

In Fig. 6, show another embodiment that comprises in the different phase of assembling with the mode of perspective view through the lamellar body bag volume of bag stack 100 made according to the method for the present invention.

Bag stack 100 comprises a plurality of medicinal bags, and 28 bags for example are wherein only to see uppermost medicinal bag 4.Medicinal bag comprises the lamellar body 2 that is encapsulated in the inside.Lower boundary 17 places on the border that serves as a mark have mark part 18.Has mark 3 on a mark part therein.Second medicinal bag (invisible) below the visible medicinal bag on be arranged in, this labelling are provided in the tight adjacent mark part of residing first mark part of mark on the wherein uppermost medicinal bag.

Medicinal bag 4, on the both sides 13,13 ' upper zone located in, be shaped on recess, and had perforation 12.In addition, medicinal bag has slotted hole 8, and confined state middle rib 214 on the regular payroll passes slotted hole 8.

In Fig. 6 a, clamp device 200 is illustrated on the carrier bar 300.Clamp device is formed two parts: it has lower part 210 and top 220.The lower part comprises rib 214, framework 215 and substrate 213.Rib passes slotted hole 8 from below.Framework 215 is positioned on the border of substrate 213.It limits three sides and limits substrate on the 4th side sections ground.When lacking framework, medicinal bag 4 can arrive the top, coupling part with perforation.And this framework is the going up (first) part and therefore guide this part of encapsulated drug bag comfily, so that they firmly are fixed in the lamellar body bag volume by ground very close to each other.The top of clamp device is formed by plate 220, and it can type of service cooperates or material combines to be secured on the lower part.This plate 220 for example utilizes material to combine (the bonding or similar approach through binding agent) to be connected to carrier bar 300.

The lower part 210 of clamp device 200 is for example through the bonding carrier bar 300 that is secured to of binding agent.When making stack by medicinal bag or making first's stack by medicinal bag 4, preferably at first with the carrier bar together with lower part 210 put into box 25,25 ', 25 ", 25 " ' ... (Fig. 1).Then medicinal bag is placed on these, the rib 214 that is secured to the lower part of the clamp device on the carrier bar slips in the slotted hole 8 of bag.Medicinal bag is remained on the carrier bar by this rib and framework 215.In addition, its position is correctly fixing by framework.

Stacked up and down after all medicinal bags 4 of lamellar body bag volume, carrier bar 300 is provided the stripes 350 of each day in one week of expression.The stripes of representing each day in the week can be set on the position shown in Fig. 6 a or Fig. 6 e shown in the position on.The stripes of representing each day in the week be configured to medicinal bag 4 on 18 one-tenth lines of mark part.Which day of a week this lamellar body that allows User Recognition to be arranged in the medicinal bag above it must be taken.

Then, the carrier bar 300 that turns back in the upper end makes this end form the lid 320 of lamellar body bag volume.For example relevant with manufacturer and medicine name information can be provided in to cover.In this example, cover and extending above the whole area of medicinal bag 4 and above the projection of lower end carrier on the regular payroll.

Thereby the lower end of the carrier bar 300 that turns back obtains piece 340.Lid 320 arrives this piece.These two parts are interconnected through releasable closing device.For example, the magnetic button can be set at the inboard of lid and the outside of piece.

In case turned back and closed Connection Element, promptly accomplished the assembling of lamellar body bag volume.

Another embodiment that in Fig. 7, has represented lamellar body bag volume.The same with the instance of volume among Fig. 5, in closure state, the lid of carrier 300 330 is moved to bag stack 100 tops and is hidden a bag stack 100 from below.Compare with the embodiment of Fig. 5, rivet is used as Connection Element 200.The respective openings in lid is as the closing device of lamellar body bag volume simultaneously for this rivet, and promptly the extended portion of rivet is inserted in the hole of lid.

Fig. 8 shows the perspective view of the lamellar body bag volume of being made by prefabricated medicinal bag, and stack 100 is similar to Fig. 4 substantially, though in all cases

medicinal bag

4,4 ', 4 " have side cut in addition and remove portion 16.Excision portion 16 lay respectively at first and second medicinal bags zones, 10, the 11 public medicinal bags that have 4,4 ', 4 " the border on, each excision portion be configured to medicinal bag adjacent one another are 4,4 ', 4 " in increase gradually to next medicinal bag from a medicinal bag from the face of facing down.All

medicinal bags

4,4 from stack 100 ', 4 " in the top see, formed the successive excision portion 16 of the step shape from the medicinal bag to the medicinal bag.For example in manufacture process from each

medicinal bag

4,4 ', 4 " the excision portion 16 that stamps out appears the image of the pictorial symbolization of representing with two points 21, pictorial symbolization 21 be introduced into respectively the medicinal bag 4 that is arranged in below the stack 100 ', 4 " on the zone of excision portion 16.

In the present embodiment, stack 100 is arranged on the carrier 300.Stack 100 and carrier through three rivets 200,200 ', 200 " interconnect.Alternatively, also can be only with a rivet 200 ' or for example stack 100 is connected on the carrier according to the Connection Element of Fig. 4.On the medicinal bag 4 that is positioned at the top, can see that mark 3 and mark part 18 are arranged in second medicinal bag zone 11.

In the present embodiment; Carrier 300 has the zone 360 that projection exceeds the lower boundary in second medicinal bag zone 11; And on this zone, have time marker 350 (stripes of representing each day in the week), represent that here the time marker of each day in the week aligns with mark part 18.

Time marker 350 for example is provided through binding agent is attached, and has the indication of each day in the week that shows with German " Mo ", " Di ", " Mi ", " Do ", " Fr ", " Sa " and " So ".First day the indicated number that this stripes is made into to make one week of expression is in the leftmost side.First mark 3 that aligns with the indication of representing " Mo " in the week is provided on the medicinal bag 4 that is positioned at the top.Other mark 3 is not illustrated, and has hidden because they are positioned at the medicinal bag 4 of their tops.

Claims

1. make the medicinal bag (4 of storing and preserving medicine lamellar body (2) for one kind; 4 '; The method of stack 4 ") (100); each medicinal bag (4; 4 '; 4 ") on mark boundaries (17), have mark (3) respectively; Each mark is arranged in said mark boundaries (17) and locates of a plurality of mark parts (18) disposed adjacent one another; Said method comprises following processing step: stack medicinal bag (4 up and down; 4 '; 4 ") to form at least one stack (100); so as in said at least one stack (100), to have medicinal bag adjacent one another are (4; 4 '; 4 "); Their mark (3) is set in the mark part adjacent one another are (18); And the medicinal bag (4 that has alternatively, mark (3) at first end of mark boundaries (17); 4 '; 4 ") second end that is adjacent to mark boundaries (17) have mark (3) medicinal bag (4; 4 '; 4 ").

2. method according to claim 1 is characterized in that, said method comprises following processing step:

A) in first manufacturing installation (30), stack up and down medicinal bag (4,4 ', 4 ") to be to form at least one first's stack; so that in each first's stack, have medicinal bag adjacent one another are (4,4 ', 4 "); Their mark (3) is arranged in mark part adjacent one another are (18); And randomly, first end of mark boundaries (17) have mark (3) medicinal bag (4,4 ', 4 ") second end that is adjacent to mark boundaries (17) has the medicinal bag (4,4 ', 4 ") of mark (3);

B) in second manufacturing installation (30 '); With other medicinal bag (4,4 ', 4 ") stack on said at least one first's stack; so that in each the part stack that forms by this way, have medicinal bag adjacent one another are (4,4 ', 4 "); Their mark (3) is arranged in mark part adjacent one another are (18); And randomly, first end of mark boundaries (17) have mark (3) medicinal bag (4,4 ', 4 ") second end that is adjacent to mark boundaries (17) has the medicinal bag (4,4 ', 4 ") of mark (3);

C) randomly; Through in other manufacturing installation (30 "), respectively other medicinal bag (4,4 ', 4 ") is stacked second or another manufacturing installation (30 ') at least one part stack of making; And repeat one-time process step b) at least, thereby finally form at least one medicinal bag (4,4 ', the stack (10) of 4 ").

3. method according to claim 2; It is characterized in that; In said first manufacturing installation (30) through stack up and down medicinal bag (4,4 ', 4 ") make first's stack; in the second and the 3rd manufacturing installation (30 ') through with other medicinal bag (4,4 ', 4 ") stack make on each previous part stack that forms at least one second with the third part stack, and in the 4th manufacturing installation (30 ") through other medicinal bag (4,4 ', 4 ") is stacked and makes at least one stack (100) on each third part stack.

4. method according to claim 1 is characterized in that, said method comprises following processing step:

A) in first manufacturing installation (30), stack medicinal bag (4 up and down; 4 '; 4 ") to form at least one first's stack; and in all cases; other manufacturing installation (30 '; form at least one other part stack in 30 "); So that in each first's stack and other part stack, have medicinal bag adjacent one another are (4; 4 '; 4 "); their mark (3) is arranged in mark part adjacent one another are (18); and randomly, first end of mark boundaries (17) have mark (3) medicinal bag (4; 4 '; 4 ") second end that is adjacent to mark boundaries (17) has the medicinal bag (4 of mark (3); 4 '; 4 ");

B) overlay up and down said at least one first's stack that processing step forms in a) and said other part stack with form at least one medicinal bag (4,4 ', the stack (100) of 4 "); so that in each stack (100), have medicinal bag adjacent one another are (4,4 ', 4 "); Their mark (3) is arranged in mark part adjacent one another are (18); And randomly, first end of mark boundaries (17) have mark (3) medicinal bag (4,4 ', 4 ") second end that is adjacent to mark boundaries (17) has the medicinal bag (4,4 ', 4 ") of mark (3).

5. method according to claim 4 is characterized in that, in all cases, four part stack are stacked up and down, thus form medicinal bag in all cases (4,4 ', the stack (100) of 4 ").

6. according to the described method of aforementioned arbitrary claim, it is characterized in that, seven mark parts (18) be set at each medicinal bag (4,4 ', on the mark boundaries (17) of 4 ").

7. according to the described method of aforementioned arbitrary claim, it is characterized in that, in all cases, seven medicinal bags (4,4 ', 4 ") are stacked up and down and form first's stack.

8. according to arbitrary described method in the claim 2 to 7, it is characterized in that, in all cases, through stack up and down medicinal bag (4,4 ', 4 ") produce at least two first's stack simultaneously.

9. according to the described method of aforementioned arbitrary claim, it is characterized in that, in all cases, in box (25,25 ', 25 ", 25 " '), stack up and down medicinal bag (4,4 ', 4 ") are with the fabrication portion stack.

10. according to the described method of aforementioned arbitrary claim, it is characterized in that, in all cases, on carrier (300), stack up and down medicinal bag (4,4 ', 4 ") to be to make corresponding first stack.

11. method according to claim 10; It is characterized in that; Said carrier (300) have with medicinal bag (4,4 ', 4 ") remain at least one Connection Element (200) on the said carrier (300); and other medicinal bag (4,4 ', the other part stack of 4 ") or medicinal bag (4,4 ', 4 ") stacked on the said first stack so that said other medicinal bag (4,4 ', 4 ") or be included in medicinal bag in the said other part stack (4,4 ', 4 ") and also kept by said Connection Element (200).

12. method according to claim 11 is characterized in that, said carrier (300) also have be used for medicinal bag (4,4 ', 4 ") direct into the guide element (215) on the said carrier (300).

13., it is characterized in that time marker (350) is provided on the said carrier (300) with the mode of aliging with mark part (18) according to arbitrary described method among the claim 10-12.

14. method according to claim 13 is characterized in that, time marker (350) is indicated each day in the week.

15. according to the described method of aforementioned arbitrary claim, it is characterized in that, medicinal bag (4,4 ', 4 ") pass through, and the singulation manufacturing forms from the prefabricated medicinal bag (7).

16., it is characterized in that said method comprises the steps: according to the described method of aforementioned arbitrary claim

I) prefabricated medicinal bag (7) is provided; At least two adjacent columns (R) of said prefabricated medicinal bag (7) inclusion region (5); Medicinal bag (4,4 ', 4 ") are come out to form through singulation from row, and mark (3) is provided in the mark part adjacent one another are (18) on the zone adjacent one another are (5) in the row (R);

Ii) separate said at least two adjacent columns (R) along at least one separator bar (11) of split bar (R), comprise medicinal bag adjacent one another are in the row (R) (4,4 ', the stripes (9) of 4 ") formed with the mode corresponding to row (R) number;

Iii) through separate from stripes (9) each monomer medicine bag (4,4 ', 4 "), singulation be included in medicinal bag in the stripes (9) of corresponding formation (4,4 ', 4 ");

Iv) stack the singulation of corresponding stripes (9) medicinal bag (4,4 ', 4 ") to be to form corresponding stack (100); like this in each stack (100); from a medicinal bag (4,4 ', 4 ") to next medicinal bag (4,4 ', 4 ") little by little, medicinal bag (4,4 ', the respective token (3) on 4 ") is set in the mark part adjacent one another are (18).

17. method according to claim 16; It is characterized in that; Processing step i) is included in transporting direction (22) in addition and goes up transportation prefabricated medicinal bag (7); It is adjacent that said at least two row (R) are parallel to said transporting direction (22); And zone (5) is adjacent one another are on said transporting direction, said separator bar (11) following said transporting direction (22) and medicinal bag (4,4 ', 4 ") go up adjacent one another are at said transporting direction (22).

18. according to the described method of aforementioned arbitrary claim, it is characterized in that, stack (100) comprise 28 medicinal bags (4,4 ', 4 ").

19. according to the described method of aforementioned arbitrary claim; It is characterized in that; Said stack (100) is placed on carrier (300) and upward and through Connection Element (200) is connected to carrier (300); Perhaps, medicinal bag (4,4 ', 4 ") are overlayed, and carrier (300) is gone up and be connected to carrier (300) through said Connection Element (200).

20. according to the described method of aforementioned arbitrary claim, it is characterized in that, the medicinal bag that comprises medicine lamellar body (2) of being used for tearing (4,4 ', the perforation (12) in second medicinal bag zone (11) of 4 ") is introduced into each medicinal bag (4,4 ', 4 ") respectively.

21. method according to claim 20 is characterized in that, said mark (3) is arranged in said second medicinal bag zone (11).

22. according to arbitrary described method in the claim 16 to 21, it is characterized in that, separate said at least two adjacent columns (R) and carry out through cutting.

23. according to arbitrary described method in the claim 16 to 22, it is characterized in that, singulation be included in medicinal bag in the stripes (9) of formation (4,4 ', 4 ") carry out through cutting or punching press.

24., it is characterized in that said prefabricated medicinal bag (7) is a plate according to arbitrary described method in the claim 16 to 23.

25. method according to claim 24 is characterized in that, each plate (7) comprise medicinal bag adjacent one another are (4,4 ', six row adjacent one another are or eight row (R) of 4 "), and have in every row (R) seven medicinal bags adjacent one another are (4,4 ', 4 ").

26. according to arbitrary described method in the claim 16 to 25; It is characterized in that; Stack the medicinal bag of singulation (4,4 ', 4 ") provide another step before; wherein; in all cases; medicinal bag (4,4 ', 4 ") are provided border excision portion (16) in addition; Make excision portion (16) in stack (100) from medicinal bag (4,4 ', 4 ") to medicinal bags (4,4 ', 4 ") increase gradually; And from all medicinal bags (4,4 ', the top of 4 ") sees, in stack (100), forms the successive excision portion (16) of step shape.

27., it is characterized in that medicine lamellar body (2) is designed to contraception or hormone replaces treatment according to the described method of aforementioned arbitrary claim.

28. medicinal bag (4 that is used for making storage and preserves medicine lamellar body (2); 4 '; The prefabricated medicinal bag (7) of stack 4 ") (100); said prefabricated medicinal bag (7) comprise medicinal bag adjacent one another are (4; 4 '; 4 ") at least two adjacent columns (R); And each medicinal bag (4; 4 '; 4 ") on mark boundaries, have mark (3) respectively; each mark is arranged in of said mark boundaries place a plurality of mark parts (18) disposed adjacent one another; and mark (3); so that the medicinal bag adjacent one another are in the row (R) (4; 4 '; 4 ") on mark (3) be provided in the mode in the mark part adjacent one another are (18), be arranged at each medicinal bag (4 on the said prefabricated medicinal bag (7); 4 '; 4 ").

29. prefabricated medicinal bag according to claim 28 (7) is characterized in that, has seven mark parts (18) on each mark boundaries.

30. according to claim 28 or 29 described prefabricated medicinal bags (7), it is characterized in that, have in every row (R) seven medicinal bags (4,4 ', 4 ").

31., it is characterized in that medicine lamellar body (2) comprises and is used to practise contraception or hormone replaces the medicine of treatment according to arbitrary described prefabricated medicinal bag (7) in the claim 28 to 30.

32. according to arbitrary described prefabricated medicinal bag (7) in the claim 28 to 31, it is characterized in that, in all cases, medicinal bag (4,4 ', 4 ") have pictorial symbolization (21) in addition at boundary.

33. according to the purposes of arbitrary described prefabricated medicinal bag (7) among the claim 28-32, its medicinal bag that is used for making storage and preserve medicine lamellar body (2) (4,4 ', the stack (100) of 4 ").

34. purposes according to arbitrary described prefabricated medicinal bag (7) among the claim 28-33; The device that it is used for making storage and preserves medicine lamellar body (2); Comprise i) comprise medicine lamellar body (2) medicinal bag (4,4 ', the stack (100) of 4 "); in all cases; said medicinal bag (4,4 ', 4 ") have seven mark parts (18); Ii) carrier (300) is arranged at seven time markeies (350) that align with mark (3) in the above.