US20080271417A1 - Method of Manufacturing Packaging Comprising Pharmaceutical Products - Google Patents
Method of Manufacturing Packaging Comprising Pharmaceutical Products Download PDFInfo
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- US20080271417A1 US20080271417A1 US12/110,917 US11091708A US2008271417A1 US 20080271417 A1 US20080271417 A1 US 20080271417A1 US 11091708 A US11091708 A US 11091708A US 2008271417 A1 US2008271417 A1 US 2008271417A1
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- United States
- Prior art keywords
- supply
- blister
- drugs
- wells
- sealing film
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B11/00—Wrapping, e.g. partially or wholly enclosing, articles or quantities of material, in strips, sheets or blanks, of flexible material
- B65B11/50—Enclosing articles, or quantities of material, by disposing contents between two sheets, e.g. pocketed sheets, and securing their opposed free margins
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B5/00—Packaging individual articles in containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, jars
- B65B5/10—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles
- B65B5/101—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles by gravity
- B65B5/103—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles by gravity for packaging pills or tablets
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B5/00—Packaging individual articles in containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, jars
- B65B5/10—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles
- B65B5/105—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles by grippers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
- A61J1/035—Blister-type containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
- A61J7/0076—Medicament distribution means
- A61J7/0084—Medicament distribution means for multiple medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2207/00—Methods of manufacture, assembly or production
Definitions
- the invention pertains to methods for producing multi-day packages which contain various drugs for several days and for several administration times.
- the multiple blister pockets of conventional blister packs are intended to hold a single type of medicament.
- a device for filling these conventional blister packs is described in, for example, DE 199 26 893 C2.
- DE 10 2004 034 024 A1 describes a blister pack in which the drug pockets are arranged in a matrix divided into days of the week and administration times with seven lines and at least three columns.
- the individual drug pockets are designed as tub-like wells formed in a thin layer of plastic, and all the tablets which are to be taken at a particular time of day are put together in one of these wells. All the drug pockets are covered with blister film, and the sections assigned to the individual administration times are separated from each other by perforations, so that the individual administration sections for certain times of day and certain days of the week can be easily separated from the rest of the pack.
- a method for producing a packaging unit of this type to accommodate the patient's medicaments for a week is known from, for example, DE 10 2004 020 510 A1.
- Strip-like supply-blister packs containing the individual medicaments are wound up into rolls.
- the strips are conveyed over the above-described packaging unit in the transverse direction, and plungers are used to push the medicaments out of the strip-like supply-blister pack into the tub-like wells of the packaging unit.
- the packaging unit designed as a “one-week blister”, is sealed as a whole with sealing film.
- the above-mentioned production method is relatively cumbersome, however, because of the complicated mechanisms required and the double packaging step of the tablets.
- the method is also critical from a contamination standpoint, because, when the tablets are pushed out by the plungers, tablet dust is created, which settles on the plungers and in the tub-like wells.
- the method for producing a multi-day package with various drugs includes the following steps: a bottom layer is formed with a plurality of wells arranged in a pattern; a predetermined number of different drugs is arranged in predetermined positions at various dispensing stations of a filling device; the desired number of drugs are picked from their predetermined positions by at least one movable suction or gripper device; the medicaments are deposited in the predetermined wells; and a sealing film is applied to the bottom layer to seal off the wells.
- several suction or gripper devices which are arranged in correspondence with the pattern of the wells in the multi-day package and which are movable parallel to each other, are actuated individually in at least one dispensing station.
- a multi-day package containing various drugs is produced in an especially simple manner, quickly and without risk of contamination.
- the arrangement of a predetermined number of a drug in predetermined positions at a dispensing station of a filling device includes the following steps: a base layer extending a considerable distance in the longitudinal and transverse directions is formed, as a result of which a plurality of supply-blister pockets is obtained; drugs are loaded into the supply-blister pockets; the supply-blister pockets are sealed by a temporary sealing film, which is applied adhesively to the webs of the base layer between the supply-blister pockets, as a result of which a supply-blister sheet is formed; and the temporary sealing film is partially removed from the supply-blister sheet to release a predetermined number of drugs to the suction or gripper devices.
- a base layer extending a considerable distance in the longitudinal and transverse directions is formed, as a result of which a plurality of supply-blister pockets is obtained
- drugs are loaded into the supply-blister pockets
- the supply-blister pockets are sealed by a temporary sealing film, which is applied adhesively to the webs of the base layer between the supply
- the supply-blister sections are not necessarily limited to a single strip-like row of supply-blister pockets but can have instead several supply-blister pockets next to each other, so that the simultaneous removal of drugs from several supply-blister pockets by several suction or gripper devices is possible not only transversely, but also longitudinally to the transport direction of the multi-day package.
- the arrangement of a predetermined number of a drug in predetermined positions at a dispensing station of a filling device can also include the step of filling the holders of a sorting plate with drugs, the holders being arranged in accordance with the pattern of the wells of the multi-day package. This is especially effective when a large number of these drugs are to be packed into each multi-day package.
- the sorting plate can be very easily filled by using a vibrating chute to supply the tablets and then to apply brushing movement.
- the suction or gripper device is preferably monitored by a camera or by means of sensors.
- FIG. 1 is a schematic top view of a multi-day package containing various medicaments after the sealing film has been partially removed;
- FIG. 2 is a cross-sectional view through the multi-day package of FIG. 1 ;
- FIG. 3 is a flow chart of a first alternative of the inventive method for producing the multi-day package
- FIG. 4 is a flow chart of a second alternative of the inventive method for producing the multi-day package
- FIG. 5 is a schematic diagram of a first filling method which can be used in the inventive production method.
- FIG. 6 is a schematic diagram of a second filling method which can be used in the inventive production method.
- FIG. 1 is a schematic top view of an example of a multi-day package 1 .
- the packaging unit 1 comprises several segments 3 , each of which is assigned to a certain time of day of a certain day of the week and can hold several medicaments.
- the segments 3 are arranged in columns and rows and are preferably separated by perforations 2 , wherein, in the exemplary embodiment shown here, the first row 4 stands, for example, for “Monday”, the second row 5 for “Tuesday”, etc.
- the division into columns corresponds to the different administration times of the medicaments during the course of a specific day of the week, wherein, for example, the first column 6 is assigned to the administration time “morning”, the second column 7 to the administration time “noon”, the third column 8 to the administration time “evening”, and the fourth column 9 to the administration time “night”. It is also possible to package medicaments for more than 7 or less than 7 days in the multi-day package (e.g., a blister pack for a whole month) or to include only certain administration times.
- FIG. 2 is a cross-sectional view of part of an inventive packaging unit 1 with several adjacent segments 3 .
- the segments 3 are formed out of a bottom layer 11 , into which relatively large wells 10 are formed, each of which can hold several drugs.
- the bottom layer 11 consists preferably of PVC film, either transparent or of any desired color, or it can consist of polypropylene or a layer laminate with aluminum.
- the wells 10 can also have a shape different from the tub-like form shown in FIG. 2 and can also be arranged in almost any regular or irregular pattern, possibly a circular pattern, for example.
- Each well 10 is closed by a sealing film 12 , which is bonded adhesively to the webs 14 of the bottom layer located between the wells 10 .
- Aluminum foil, paper-lined foil, or polypropylene film can be used as the sealing film 12 .
- the sealing film 12 has no perforations in the areas where it covers the wells 10 , so that a secure and long-lasting seal is provided for the drug until it is needed.
- the perforations 2 in the webs 14 of the bottom layer 11 which form the boundaries of the wells 10 , and those in the sealing film 12 can be seen between the individual segments 3 .
- the sealing film 12 When the sealing film 12 is pulled from the webs 14 around a well 10 , it is therefore possible to access all of the medicaments intended for a certain administration time at once. For this purpose it is important for the sealing film 12 to be relatively tear-proof.
- the sealing film 12 can also be imprinted with a list of the medicaments contained in the individual wells 10 . It is also conceivable that an additional hinged cover could be provided, on which information about the medicaments is presented.
- FIG. 3 A flow chart of a first embodiment of the inventive method for producing the multi-day package is shown in FIG. 3 .
- wells 10 to hold the drugs are formed in a bottom layer 11 (step 32 ).
- the bottom layer 11 is pulled from a roll, possibly heated in a heating station, and then provided with the wells 10 in a following forming station.
- step 34 a predetermined number of different drugs are arranged (step 34 ) in predetermined positions at various dispensing stations of the filling station.
- the steps to be carried out for this purpose in the case of the embodiment according to FIG. 3 are explained in the following.
- step 35 a base layer of considerable size in the longitudinal and transverse directions is formed, as a result of which a large number of supply-blister pockets 16 is obtained.
- the base layer is unwound from a roll, possibly heated in a heating station, and provided with the supply-blister pockets 16 in a forming station.
- the supply-blister pockets 16 are filled with drugs (step 36 ); the results are subjected to quality control, and defective products are ejected.
- step 38 the supply-blister pockets 16 are closed by a temporary sealing film, which is applied adhesively to the webs of the base layer between the supply-blister pockets 16 .
- the temporary sealing film is unwound from a roll, applied in a sealing station to the webs of the base layer between the supply-blister pockets 16 , and then cooled in a cooling station.
- the cutting of the supply-blister sheet into separate supply-blister sections comprises preferably the cutting of the supply-blister sheet in the longitudinal direction by means of a longitudinal cutter.
- the supply-blister sheet is cut in the direction in which the supply-blister sheet is traveling.
- the cuts are made preferably by circular knives mounted on a shaft. This shaft will usually be located underneath the supply-blister sheet.
- Above the supply-blister sheet there is a shaft on which a round disk is mounted opposite each of the circular knives. The cut edge is formed between the circular knife and the round disk. Hold-downs press the supply-blister sheet from above against the guide to ensure a straight cut.
- the longitudinal cutter is usually driven by a motor and a toothed belt.
- a supply-blister section can be in the form of a strip, but it can also have several supply-blister pockets 16 adjacent to each other in the transverse direction. After that, the supply-blister sections are unwound from the roll, and the temporary sealing film is removed (step 42 ).
- the medicaments are picked up in a controlled manner by means of the movable suction or gripper devices 50 and placed in the wells 10 (step 44 ).
- FIG. 5 which is a schematic diagram of a filling method for the above-mentioned embodiment, illustrates an example of a suction device 50 , which can move in the transverse direction.
- the suction device 50 is a suction arm, which can move vertically and which is driven by a control unit (not shown).
- the device is designed to pick up individual tablets from the supply-blister pockets 16 from which the sealing film 12 has previously been removed and to place them in the individual desired wells 10 formed in the bottom layer 11 . Movement in the transverse direction along a rail 52 is also conceivable, but any other guided movement which can be controlled by the control unit can be used here.
- suction arm 50 Even though only one suction arm 50 is shown in the schematic diagram, several parallel suction arms 50 are used according to the invention, which are actuated independently so that several tablets can be introduced into the wells 10 simultaneously.
- the bottom layer 11 is preferably transported in interval fashion, and the multi-day package 1 will be filled with the individual tablets row by row. Thus, several rows or segments 3 can be filled simultaneously.
- the suction arms 50 it can also be advisable for the suction arms 50 to be movable in the transport direction of the multi-day package as well.
- a camera 54 which is installed in the area of the suction devices and which preferably moves along with them, serves to monitor both the suction method and the correct placement of the tablets in the wells 10 of the bottom layer 11 .
- Other sensors are also suitable for monitoring the picking and placing of the tablets.
- the last step is the sealing of the multi-day package with the sealing film 12 (step 46 ).
- the arrangement 34 of a predetermined number of a drug in predetermined positions at a dispensing station of the filling device can also be carried out in accordance with a second embodiment, as can be seen from FIGS. 4 and 6 .
- the holders of a sorting plate 56 which are arranged in correspondence with the pattern of the wells 10 in the multi-day package, are filled with drugs.
- the individually controlled suction or gripper devices 50 can be arranged above the sorting plate 56 in correspondence with the pattern of the holders. This is especially effective when large numbers of these drugs are to be packed into each multi-day package.
- the placing of the drugs onto the sorting plate 56 is preferably accomplished by means of a vibrating chute.
- a brushing movement with a brush device 58 is then preferably carried out, which also takes care of removing excess tablets from the sorting plate 56 .
Abstract
The method for producing a multi-day package containing various drugs has the following steps: a bottom layer is formed with a plurality of wells arranged in a pattern; a predetermined number of different drugs is arranged in predetermined positions at various dispensing stations of a filling device; the desired number of drugs are picked in a controlled manner from their predetermined positions at each dispensing station by at least one movable suction or gripper device, and the drugs are deposited in the predetermined wells; and a sealing film is applied to the bottom layer to seal off the wells. In the course of this method, in at least one dispensing station several suction or gripper devices, which are arranged in correspondence with the pattern of the wells in the multi-day package and which travel parallel to each other, are actuated individually.
Description
- This application claims priority based on European patent application EP 07 008 966.9, filed May 3, 2007.
- The invention pertains to methods for producing multi-day packages which contain various drugs for several days and for several administration times.
- The multiple blister pockets of conventional blister packs are intended to hold a single type of medicament. A device for filling these conventional blister packs is described in, for example, DE 199 26 893 C2.
- In the treatment of patients with chronic diseases, however, there is often room for improvement with respect to the patient's ability to take his or her medicaments consistently in accordance with the prescribed therapy. This is especially true when different sets of tablets must be taken at different times of day. To provide a memory aid which helps the patient take his or her medicaments correctly and also to ensure a reliable overview as to which medicaments have already been taken,
DE 10 2004 034 024 A1 describes a blister pack in which the drug pockets are arranged in a matrix divided into days of the week and administration times with seven lines and at least three columns. The individual drug pockets are designed as tub-like wells formed in a thin layer of plastic, and all the tablets which are to be taken at a particular time of day are put together in one of these wells. All the drug pockets are covered with blister film, and the sections assigned to the individual administration times are separated from each other by perforations, so that the individual administration sections for certain times of day and certain days of the week can be easily separated from the rest of the pack. - A method for producing a packaging unit of this type to accommodate the patient's medicaments for a week is known from, for example,
DE 10 2004 020 510 A1. Strip-like supply-blister packs containing the individual medicaments are wound up into rolls. At various dispensing stations, the strips are conveyed over the above-described packaging unit in the transverse direction, and plungers are used to push the medicaments out of the strip-like supply-blister pack into the tub-like wells of the packaging unit. The packaging unit, designed as a “one-week blister”, is sealed as a whole with sealing film. - The above-mentioned production method is relatively cumbersome, however, because of the complicated mechanisms required and the double packaging step of the tablets. The method is also critical from a contamination standpoint, because, when the tablets are pushed out by the plungers, tablet dust is created, which settles on the plungers and in the tub-like wells.
- Another production method is known from DE 10 2005 047 429 A1. Here a system for filling one-week blister packs is disclosed, which is intended primarily for situations in which comparatively small numbers of patients are involved (e.g., in clinical centers). Standard commercial blister packs are stored in stacks in sector magazines, each of which can be rotated to release a blister holding the desired type of tablet. The blister pocket, from which the tablet is to be taken, is then opened by punching out the blister cap. The blister cap is then removed by a suction pipette integrated into the punching tool, whereupon the suction pipette is also used to remove the tablet from the blister pocket and to load it into the one-week blister pack. The overall method is extremely complicated.
- It is an object of the present invention to create a method for producing a multi-day package holding various drugs, the method excluding contamination and being carried out easily and also very quickly.
- According to an embodiment of the invention, the method for producing a multi-day package with various drugs includes the following steps: a bottom layer is formed with a plurality of wells arranged in a pattern; a predetermined number of different drugs is arranged in predetermined positions at various dispensing stations of a filling device; the desired number of drugs are picked from their predetermined positions by at least one movable suction or gripper device; the medicaments are deposited in the predetermined wells; and a sealing film is applied to the bottom layer to seal off the wells. In the course of this method, several suction or gripper devices, which are arranged in correspondence with the pattern of the wells in the multi-day package and which are movable parallel to each other, are actuated individually in at least one dispensing station.
- Thus, a multi-day package containing various drugs is produced in an especially simple manner, quickly and without risk of contamination.
- In one embodiment, the arrangement of a predetermined number of a drug in predetermined positions at a dispensing station of a filling device includes the following steps: a base layer extending a considerable distance in the longitudinal and transverse directions is formed, as a result of which a plurality of supply-blister pockets is obtained; drugs are loaded into the supply-blister pockets; the supply-blister pockets are sealed by a temporary sealing film, which is applied adhesively to the webs of the base layer between the supply-blister pockets, as a result of which a supply-blister sheet is formed; and the temporary sealing film is partially removed from the supply-blister sheet to release a predetermined number of drugs to the suction or gripper devices. As a result, it is guaranteed that the drugs remain protected in the supply-blister pockets even during long periods of storage.
- It can be advantageous to cut the supply-blister sheet into supply-blister sections before the step of removing the temporary sealing film and to arrange the wound-up blister sections at the dispensing stations transversely to the transport direction of the multi-day package. As a result, effective access to individual, seldom-used tablets is possible. The supply-blister sections are not necessarily limited to a single strip-like row of supply-blister pockets but can have instead several supply-blister pockets next to each other, so that the simultaneous removal of drugs from several supply-blister pockets by several suction or gripper devices is possible not only transversely, but also longitudinally to the transport direction of the multi-day package.
- In another embodiment, the arrangement of a predetermined number of a drug in predetermined positions at a dispensing station of a filling device can also include the step of filling the holders of a sorting plate with drugs, the holders being arranged in accordance with the pattern of the wells of the multi-day package. This is especially effective when a large number of these drugs are to be packed into each multi-day package. The sorting plate can be very easily filled by using a vibrating chute to supply the tablets and then to apply brushing movement.
- It is also possible to apply the two embodiments of the method described above in combination, that is, at different dispensing stations of the same device.
- To simplify quality control, the suction or gripper device is preferably monitored by a camera or by means of sensors.
- By means of the additional step of introducing perforations into the bottom layer and into the sealing film between the wells, the possibility is obtained of being able to separate individual sections for specific administration times of specific days from the multi-day package.
- Additional details, features, and advantages of the present invention can be derived from the following description, which makes reference to the attached drawings.
-
FIG. 1 is a schematic top view of a multi-day package containing various medicaments after the sealing film has been partially removed; -
FIG. 2 is a cross-sectional view through the multi-day package ofFIG. 1 ; -
FIG. 3 is a flow chart of a first alternative of the inventive method for producing the multi-day package; -
FIG. 4 is a flow chart of a second alternative of the inventive method for producing the multi-day package; -
FIG. 5 is a schematic diagram of a first filling method which can be used in the inventive production method; and -
FIG. 6 is a schematic diagram of a second filling method which can be used in the inventive production method. -
FIG. 1 is a schematic top view of an example of amulti-day package 1. Thepackaging unit 1 comprisesseveral segments 3, each of which is assigned to a certain time of day of a certain day of the week and can hold several medicaments. Thesegments 3 are arranged in columns and rows and are preferably separated byperforations 2, wherein, in the exemplary embodiment shown here, thefirst row 4 stands, for example, for “Monday”, thesecond row 5 for “Tuesday”, etc. The division into columns corresponds to the different administration times of the medicaments during the course of a specific day of the week, wherein, for example, thefirst column 6 is assigned to the administration time “morning”, thesecond column 7 to the administration time “noon”, thethird column 8 to the administration time “evening”, and the fourth column 9 to the administration time “night”. It is also possible to package medicaments for more than 7 or less than 7 days in the multi-day package (e.g., a blister pack for a whole month) or to include only certain administration times. -
FIG. 2 is a cross-sectional view of part of aninventive packaging unit 1 with severaladjacent segments 3. Thesegments 3 are formed out of abottom layer 11, into which relativelylarge wells 10 are formed, each of which can hold several drugs. Thebottom layer 11 consists preferably of PVC film, either transparent or of any desired color, or it can consist of polypropylene or a layer laminate with aluminum. Thewells 10 can also have a shape different from the tub-like form shown inFIG. 2 and can also be arranged in almost any regular or irregular pattern, possibly a circular pattern, for example. - Each
well 10 is closed by asealing film 12, which is bonded adhesively to thewebs 14 of the bottom layer located between thewells 10. Aluminum foil, paper-lined foil, or polypropylene film can be used as thesealing film 12. Thesealing film 12 has no perforations in the areas where it covers thewells 10, so that a secure and long-lasting seal is provided for the drug until it is needed. Theperforations 2 in thewebs 14 of thebottom layer 11, which form the boundaries of thewells 10, and those in thesealing film 12 can be seen between theindividual segments 3. - When the
sealing film 12 is pulled from thewebs 14 around a well 10, it is therefore possible to access all of the medicaments intended for a certain administration time at once. For this purpose it is important for thesealing film 12 to be relatively tear-proof. - The
sealing film 12 can also be imprinted with a list of the medicaments contained in theindividual wells 10. It is also conceivable that an additional hinged cover could be provided, on which information about the medicaments is presented. - A flow chart of a first embodiment of the inventive method for producing the multi-day package is shown in
FIG. 3 . - First,
wells 10 to hold the drugs are formed in a bottom layer 11 (step 32). For this purpose, thebottom layer 11 is pulled from a roll, possibly heated in a heating station, and then provided with thewells 10 in a following forming station. - Then a predetermined number of different drugs are arranged (step 34) in predetermined positions at various dispensing stations of the filling station. The steps to be carried out for this purpose in the case of the embodiment according to
FIG. 3 are explained in the following. - First, in
step 35, a base layer of considerable size in the longitudinal and transverse directions is formed, as a result of which a large number of supply-blister pockets 16 is obtained. For this purpose, the base layer is unwound from a roll, possibly heated in a heating station, and provided with the supply-blister pockets 16 in a forming station. Then the supply-blister pockets 16 are filled with drugs (step 36); the results are subjected to quality control, and defective products are ejected. In the followingstep 38, the supply-blister pockets 16 are closed by a temporary sealing film, which is applied adhesively to the webs of the base layer between the supply-blister pockets 16. For this purpose, the temporary sealing film is unwound from a roll, applied in a sealing station to the webs of the base layer between the supply-blister pockets 16, and then cooled in a cooling station. - Then the large supply-blister sheet thus produced is cut into individual supply-blister sections (step 40). The cutting of the supply-blister sheet into separate supply-blister sections comprises preferably the cutting of the supply-blister sheet in the longitudinal direction by means of a longitudinal cutter. In the longitudinal cutter, the supply-blister sheet is cut in the direction in which the supply-blister sheet is traveling. The cuts are made preferably by circular knives mounted on a shaft. This shaft will usually be located underneath the supply-blister sheet. Above the supply-blister sheet there is a shaft on which a round disk is mounted opposite each of the circular knives. The cut edge is formed between the circular knife and the round disk. Hold-downs press the supply-blister sheet from above against the guide to ensure a straight cut. The longitudinal cutter is usually driven by a motor and a toothed belt.
- As a result, supply-blister sections are produced from the supply-blister sheet, and these sections are then wound up into rolls. A supply-blister section can be in the form of a strip, but it can also have several supply-
blister pockets 16 adjacent to each other in the transverse direction. After that, the supply-blister sections are unwound from the roll, and the temporary sealing film is removed (step 42). - Then the medicaments are picked up in a controlled manner by means of the movable suction or
gripper devices 50 and placed in the wells 10 (step 44). -
FIG. 5 , which is a schematic diagram of a filling method for the above-mentioned embodiment, illustrates an example of asuction device 50, which can move in the transverse direction. In this schematic diagram of an exemplary embodiment, thesuction device 50 is a suction arm, which can move vertically and which is driven by a control unit (not shown). The device is designed to pick up individual tablets from the supply-blister pockets 16 from which the sealingfilm 12 has previously been removed and to place them in the individual desiredwells 10 formed in thebottom layer 11. Movement in the transverse direction along arail 52 is also conceivable, but any other guided movement which can be controlled by the control unit can be used here. - Even though only one
suction arm 50 is shown in the schematic diagram, severalparallel suction arms 50 are used according to the invention, which are actuated independently so that several tablets can be introduced into thewells 10 simultaneously. Thebottom layer 11 is preferably transported in interval fashion, and themulti-day package 1 will be filled with the individual tablets row by row. Thus, several rows orsegments 3 can be filled simultaneously. For this purpose it can also be advisable for thesuction arms 50 to be movable in the transport direction of the multi-day package as well. - A
camera 54, which is installed in the area of the suction devices and which preferably moves along with them, serves to monitor both the suction method and the correct placement of the tablets in thewells 10 of thebottom layer 11. Other sensors are also suitable for monitoring the picking and placing of the tablets. - The last step is the sealing of the multi-day package with the sealing film 12 (step 46).
- The
arrangement 34 of a predetermined number of a drug in predetermined positions at a dispensing station of the filling device can also be carried out in accordance with a second embodiment, as can be seen fromFIGS. 4 and 6 . - In this case, the holders of a sorting
plate 56, which are arranged in correspondence with the pattern of thewells 10 in the multi-day package, are filled with drugs. The individually controlled suction orgripper devices 50 can be arranged above the sortingplate 56 in correspondence with the pattern of the holders. This is especially effective when large numbers of these drugs are to be packed into each multi-day package. The placing of the drugs onto the sortingplate 56 is preferably accomplished by means of a vibrating chute. To ensure that all of the holders of the sortingplate 56 are filled, a brushing movement with abrush device 58 is then preferably carried out, which also takes care of removing excess tablets from the sortingplate 56. - By means of the filling method shown schematically in
FIG. 6 , where, for reasons of clarity the sortingplate 56 is shown reduced in size and where only twosuction devices 50 of the matrix arrangement ofsuction devices 50 corresponding to the pattern ofwells 10 in the multi-day package are shown, it is possible to pick the drugs from the sortingplate 56 in any desired pattern and to place them in the correspondingwells 10 in the multi-day package, whereupon the empty holders are refilled. - It is possible to apply the embodiments of the method described above in combination, that is, at different dispensing stations of the same filling device.
- Thus, in an especially simple and rapid manner, a multi-day package for various drugs is created, in which the medicaments are sorted by administration times.
Claims (7)
1. A method for producing a multi-day package containing various drugs comprising the following steps:
forming a bottom layer with a plurality of wells arranged in a pattern;
arranging a predetermined number of different drugs in predetermined positions at various dispensing stations of a filling device;
picking the desired number of drugs in a controlled manner from their predetermined positions at each dispensing station by at least one movable suction or gripper device, and placing the drugs in predetermined wells; and
applying a sealing film to the bottom layer to seal off the wells,
wherein, in at least one dispensing station, several suction or gripper devices are arranged in correspondence with the pattern of the wells in the multi-day package, are actuated individually and travel parallel to each other.
2. The method of claim 1 wherein the step of arranging a predetermined number of a drug in predetermined positions at a dispensing station of a filling device includes the following steps:
forming a base layer extending a considerable distance in the longitudinal and transverse directions, as a result of which the plurality of supply-blister pockets is obtained; and
loading the drugs into the supply-blister pockets;
sealing the supply-blister pockets with a temporary sealing film, which is applied adhesively to the webs of the base layer between the supply-blister pockets, as a result of which a supply-blister sheet is formed; and
partially removing the temporary sealing film from the supply-blister sheet to release a predetermined number of drugs to the suction or gripper devices.
3. The method of claim 2 further comprising the additional step that, before the step of removing the temporary sealing film from the supply-blister sheet, the supply-blister sheet is cut into supply-blister sections, and the supply-blister sections are arranged on rolls at the dispensing station transversely to the transport direction of the multi-day package.
4. The method of claim 1 wherein the step of arranging a predetermined number of a drug in predetermined positions at a dispensing station of a filling device comprises the step of filling the holders of a sorting plate with drugs, the holders being arranged in correspondence with the pattern of the multi-day package.
5. The method of claim 4 wherein the sorting plate is filled completely by an oscillating movement of a vibrating chute, followed by a brushing movement of a brush device.
6. The method of claim 1 wherein each of the minimum of one suction or gripper devices is monitored by means of a camera or by sensors.
7. The method of claim 1 further comprising the additional steps that perforations are introduced into the bottom layer and into the sealing film between the wells.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07008966.9 | 2007-05-03 | ||
EP07008966A EP1988019B1 (en) | 2007-05-03 | 2007-05-03 | Method for manufacturing supply packs with various medicines for several days |
Publications (1)
Publication Number | Publication Date |
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US20080271417A1 true US20080271417A1 (en) | 2008-11-06 |
Family
ID=38523451
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Application Number | Title | Priority Date | Filing Date |
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US12/110,917 Abandoned US20080271417A1 (en) | 2007-05-03 | 2008-04-28 | Method of Manufacturing Packaging Comprising Pharmaceutical Products |
US12/110,840 Abandoned US20080295460A1 (en) | 2007-05-03 | 2008-04-28 | Method of Manufacturing Packaging Comprising Pharmaceutical Products |
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Application Number | Title | Priority Date | Filing Date |
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US12/110,840 Abandoned US20080295460A1 (en) | 2007-05-03 | 2008-04-28 | Method of Manufacturing Packaging Comprising Pharmaceutical Products |
Country Status (3)
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US (2) | US20080271417A1 (en) |
EP (2) | EP1988019B1 (en) |
DE (2) | DE502007001135D1 (en) |
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US20160122060A1 (en) * | 2014-11-04 | 2016-05-05 | Mts Medication Technologies, Inc. | Systems and methods for automatically verifying packaging of solid pharmaceuticals via robotic technology according to patient prescription data |
US9351907B2 (en) | 2011-07-19 | 2016-05-31 | Id-Con, Llc | Packaging systems and methods |
US20180319519A1 (en) * | 2015-08-25 | 2018-11-08 | Bayer Pharma Aktiengesellschaft | Blister packaging |
WO2019035325A1 (en) * | 2017-08-16 | 2019-02-21 | 株式会社イシダ | Box packing device |
US10934032B2 (en) | 2014-11-05 | 2021-03-02 | Mts Medication Technologies, Inc. | Dispensing canisters for packaging oral solid pharmaceuticals via robotic technology according to patient prescription data |
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JP2010001739A (en) * | 2008-02-20 | 2010-01-07 | Toyota Motor Corp | Thermostat device |
EP2343243B1 (en) | 2010-01-07 | 2012-06-13 | Uhlmann VisioTec GmbH | Assembly for monitored filling of solid pharmaceutical products |
DE102017130735A1 (en) | 2017-12-20 | 2019-06-27 | Delphi Salesconsulting Ag | Device for automated modification of the composition of a batch |
DE102020131097A1 (en) | 2020-11-24 | 2022-05-25 | go.ecoblister GmbH | Medication container, set for forming a medicament container and method for providing and method for opening a medicament container |
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US9027786B2 (en) | 2010-12-08 | 2015-05-12 | Mark C. Doyle | Packaging systems and methods |
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US20180319519A1 (en) * | 2015-08-25 | 2018-11-08 | Bayer Pharma Aktiengesellschaft | Blister packaging |
US10889393B2 (en) * | 2015-08-25 | 2021-01-12 | Bayer Pharma Aktiengesellschaft | Macro blister packaging |
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JPWO2019035325A1 (en) * | 2017-08-16 | 2020-07-30 | 株式会社イシダ | Boxing equipment |
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US11524808B2 (en) * | 2017-08-16 | 2022-12-13 | Ishida Co., Ltd. | Box packing apparatus |
JP7340250B2 (en) | 2017-08-16 | 2023-09-07 | 株式会社イシダ | packaging equipment |
Also Published As
Publication number | Publication date |
---|---|
DE502007000406D1 (en) | 2009-03-12 |
EP1988019B1 (en) | 2009-01-21 |
EP1988019A1 (en) | 2008-11-05 |
DE502007001135D1 (en) | 2009-09-03 |
EP2000410B1 (en) | 2009-07-22 |
EP2000410A1 (en) | 2008-12-10 |
US20080295460A1 (en) | 2008-12-04 |
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