KR20110072636A - Cosmetic composition comprising the herbal mixed extract comprising poria cocos showing hair-growth stimulating activity and preventing activity from hair loss - Google Patents

Abstract

PURPOSE: A cosmetic composition containing Wolfporia cocos extract is provided to promote hair growth and to prevent hair loss without toxicity and side effects. CONSTITUTION: A cosmetic composition with effects of preventing hair loss and promoting hair growth contains complex extract of Wolfporia cocos, Rehmannia root, Ecliptae Herba, Acyranthes bidentata Blume, and dodder as an active ingredient. The extract is isolated using water including purified water, low alcohol of 1-4 carbon atoms, or mixture solvent thereof. Rehmannia root is dried Rehmannia root, steamed Rehmannia root, or raw Rehmannia root.

Description

Cosmetic composition having a hair loss prevention and hair growth promoting effect containing a compound herbal extracts such as Fukryeong {Cosmetic composition comprising the herbal mixed extract comprising poria cocos showing hair-growth stimulating activity and preventing activity from hair loss}

The present invention relates to a cosmetic composition having anti-hair loss, anti-dandruff production, scalp pruritus improvement effect and hair growth promoting effect containing complex herbal extracts of Bokryeong, sewage, baeksuo, jihwang, nasturtium, dew, earth and sand and golgol.

[Document 1] Korean Patent No. 0157667 (1998. 07. 31)

[Document 2] Republic of Korea Patent No. 0161338 (1998. 08. 24)

[Document 3] Korean Patent No. 259037 (2000. 03. 16)

[Document 4] Korean Patent No. 0260673 (2000. 04. 11)

[Reference 5] Information Sub and Shin Min-kyo, Hyang-Yaksa Dictionary, pp.40-42, Younglimsa, 1998

[Ref. 6] Jung Sup and Shin Min-kyo, Hyang-Yaksa Dictionary, pp.318-319, Younglimsa, 1998

[Ref. 7] Jung-seop Shin and Min-Kyo Shin, Hyang-Yaksa Dictionary, pp.984-985, Younglimsa, 1998

[Ref. 8] Jung-Seop Shin and Min-Kyo Shin, Hyang-Yaksa Dictionary, pp.906-907, Younglimsa, 1998

[Document 9] Information Sub and Shin Min-kyo, Hyang-Yaksa Dictionary, pp.1043-1044, Younglimsa, 1998

[Ref. 10] Jung-seop Jung and Shin Min-kyo, Hyangjeomsa Dictionary, p.340, Younglimsa, 1998

[Reference Document 11] Jung-Seop Jung and Shin Min-kyo, Hyang-Yak Dictionary, p.882, Younglimsa, 1998

[Ref. 12] Jung-Seop Shin and Min-Kyo Shin, Hyang-Yaksa Dictionary, pp.702-703, Younglimsa, 1998

      Human hair has a hair cycle, and after a certain period of time comes to rest from the scalp and fall out irrespective of the hair cycle is called alopecia, is also called toxicosis (禿髮 症) or apox (禿頭 病) disease. In other words, it is a condition in which abnormal hair loss or hair is not present or is poor. Not only the hair but also all the hair stops growing after a certain period of growth, and then enters the resting phase, depilates and repeats the hair growth. This is called the hair growth cycle. The growth cycle of eyebrows, eyelashes, and fluffy is less than 6 months. On the other hand, hair growth is longer than 2 to 6 years, resting period is shorter than 2 to 3 months, and each has an independent growth cycle. Adults have 2 to 5% of their hair at rest. The hairs at rest are lightly pigmented, glossy, hairy, and easily pulled off with hair and comb. In addition, fever disease, pregnancy, mental stress, such as the growth phase of the hair suddenly enters the resting period, a lot of missing, the cause is eliminated and is recovered. The causes of hair loss known to date include excessive sebum production due to abnormal circulation, abnormal circulation, blood circulation disorders, nutrient deprivation of hair roots, physical factors such as allergies and bacterial infections, genetic factors such as the effects of male hormones, various pollution and processing. It is caused by a combination of environmental factors such as food, shampoo, soap, mousse, hair gel, hair spray, perm, dyeing, hair dryer, psychosocial factors of modern people who are over stressed, and aging. It is estimated. In recent years, most hair loss patients have been found to be responsible for hair loss. Demodex is a parasitic mite belonging to spiders and aphids, which live on the sebaceous glands and hair follicles of human eyelids, around the nose, the ear canal, and the head. Among the conventional hair growth promoting drugs for treating such alopecia, oral finasteride (Finasteride, Merk, USA) and external preparation minoxidil (Minoxidil, Upjohn, USA). Minoxidil has a capillary dilation function that prevents hair loss by applying it to the scalp, but it must be applied twice a day continuously, and only after the drug stays on the scalp for 3 to 4 hours for some effect. In terms of the effect is inadequate, side effects such as itching, irritation appear. Finasteride (Finasteride) has the effect of inhibiting the production of 5α-dihydrotestosterone (DHT), a male hormone that causes hair loss, and is known to show hair growth or hair loss inhibitory effects when taken for 6 months to 1 year. There was a problem returning to the original state. In addition, side effects may include decreased sexual function, such as decreased libido, erectile dysfunction, etc. Women are known to not take because of the risk of birth defects.

     There have also been many attempts to promote hair growth by applying or taking herbal medicines to the scalp, using the extract of orchid plants (Korean Patent No. 0157667), and using the wormwood and mandrel (Korean Patent No. 0161338). ), Half, clove, Bokbunja, Sancho, Manza, Dansam and white porcelain (Korean Patent No. 259037), mungbean flour, soybean flour, black rice flour, perilla sesame powder, sesame powder, walnut powder, laver powder, mussel powder, Oyster powder, anchovy powder, seaweed powder, kelp powder, yeast concentrate or dry powder thereof (Korean Patent No. 0260673) has been published, but its principle of action is not clear and its efficacy has not been sufficiently verified. It is true.

     As described above, the above-mentioned hair restorers have problems such as economic burdens and pains to hair loss patients or cause side effects, use of only temporary or fragmentary pharmacological mechanisms, and the effects are more excellent and persistent. There is a growing demand for drugs that do not have side effects.

Pokryeong (茯 笭, Poria cocos ) is a dried fungal nucleus of Poria cocos, which is parasitic on the roots of pine trees such as pine trees. ), And the pink fungal nucleus in the outer shell is called Red Bok-Ryung-Ryong (赤 茯 笭), and known ingredients include β-pachyman, triterpenoid, pachymic acid, and turmeric logic extract ( tumulosic acid), 3 β-hydroxysilanostar-7,9 (11) (3 β-hydroxylanosta-7,9 (11)), 24-triene-2-acid, Chitin, sterol, lecithin, adenine, histidine, choline, lipase, proteinase, etc. (Information and Shin Min-kyo, Hyang-Yaksa Dictionary, pp.40-42, Younglimsa, 1998).

Sewage (何首烏, Polygonum multiflorum ) is a perennial herbaceous herbaceous herb in the form of reddish brown vines, and known ingredients include anthraquinones, chrysophanol, and emodin. , Rhein, physcione, chrysophanol anthrone, lecithin, etc., have been reported (information and Shinmingyo, medicinal metabolism, pp. 318-319, Younglim , 1998).

Baeksuo ( Cynanchum wilfordii ) is a vine perennial herb, the root of the woopiso, and has been reported to contain cynanchol as a known ingredient (Information and Shinmingyo). , Hyangjeomsa Dictionary, pp.984-985, Younglimsa, 1998).

Jihwang (生地黄, Remannia giutinosa ) is a perennial herb, the root of raw is raw sulfur (生地黄), dried dried kojihwang (乾 地 黄), steamed dried sujiji (Mature 地 黄) is called the main ingredient β- Β-sitosterol, mannitol, stigmasterol, stigmasterol, campesterol, rehmanin, alkaloid, catalpinoside, glucose, vitamin A (vitamin A) It has been reported that vitamin A), stachyose, alginin, and γ-butyl amino acid (Information and Shin Mingyo, Pharmacokinetic Dictionary, pp. 906-907, Younglimsa, 1998).

Eclipta prostrata L. is a herbaceous herb that is an annual herb and is known as muk hannyeon, and known ingredients include saponin, nicotine, tannin, Vitamin A, ecliptine, thiophene, α-terthienyl methanol, [2- (buta-1,3-

diynyl) -5- (but-3-en1-ynyl) thiohpene], [2- (buta-1,3-diynyl) -5-(-4-chloro-3-hydroxy-but-1-ynyl) thiophene, etc. It has been reported that it contains (Joo In-seop and Shin Mingyo, Hyangjedae Dictionary, pp.1043-1044, Younglimsa, 1998).

Achyranthes japonica is a perennial herb and refers to the roots of iron knees or urchins with amaranth, and known ingredients include triterpenoid saponin, oleanol, and potassium salt (potassium). Iii), ecdysterone and inosterone have been reported to be contained (Information and Shin Mingyo, Hyangje Dictionary, p.340, Yeonglimsa, 1998).

Cuscuta japonica is a seed of Korean ginseng, a parasitic herb that is parasitic on the leaves of the Verbena japonica- beetle, known as vitamin A (vitamin A), β- Carotene (β-carotene), γ-carotene (γ-carotene), 5,6-epoxy-α-carotene (5,6-epoxy-α-carotene), teraxanthin, rutin It has been reported (Information and Shin Min-kyo, Hyangjeomsa, p.882, Younglimsa, 1998).

Pgolgoji ( Psoralea corylifoli a) is an annual herb that is a fruit of pagoji, and known ingredients include methylglucoside, alkali, terpene, saponine, It has been reported to contain coumarin, psoralen and isopsoralen (Information and Shin Mingyo, Pharmacological Dictionary, pp.702-703, Younglimsa, 1998).

     Accordingly, the present inventors continue to search for raw materials with excellent stability and hair growth promoting effect among the herbal extracts used as herbal medicines, complex herbal extracts of Fuling, sewage, baeksuo, jihwang, nasturtium, dew, earthenware and Bogolji Through this clinical trial, it was confirmed that the hair loss prevention, dandruff production inhibition, scalp pruritus improvement effect and hair growth promoting effect to complete the present invention.

      In order to carry out the above object, the present invention is an anti-hair loss, anti-dandruff production, scalp pruritus improvement effect and hair growth containing the complex herbal extracts of Bokryeong, sewage, baeksuo, jihwang, nasturtium, dew, earth and sand, Bogolji as an active ingredient Provided is a cosmetic composition having a promoting effect.

     The extract as defined herein includes water, including purified water, lower alcohols having 1 to 4 carbon atoms or mixed solvents thereof, preferably extracts soluble in water.

     The compound herbal extract of the present invention has a composition ratio of Bokryeong: Shouo: Baeksuo: Chihwang: Nasturtium: Essence: Tosa: Bogolji = 1-5: 1-5: 1-5: 1-5: 1-5: 1 -5: 1-5: weight ratio (w / w) of 1-5, Preferably, Fuling: Sewao: Baeksuo: Chihwang: Nasturtium: Emulsion: Earthenware: Bogolji = 1-3: 1-3: 1-3 : 1: 3: 1: 3: 1: 3: 1: 3: 1: 3: 1 ~ 3 weight ratio (w / w), more preferably Fueryeong: Shaoo: Baeksuo: Chihwang: Nasturtium: Esoteric: Earthenware: Bulgogi = It is characterized by the weight ratio (w / w) of 1 to 2: 1 to 2: 1 to 2: 1 to 2: 1 to 2: 1: 1: 1.

     As used herein, “returned spirit” can be used as baekryokyeong, red bokyeongyeong, etc., but it is preferable to use baekryokyeong; “Sewage” is preferred to use dripping water; "Turmeric" can be used, but it is preferable to use dried or sulfur.

     The cosmetic composition is a hair tonic, hair conditioner, hair essence, hair lotion, hair nutrition lotion, hair shampoo, hair rinse, hair treatment, hair cream, hair nutrition cream, hair moisturizing cream, hair massage cream, hair wax, hair aerosol , Hair pack, nourishment pack, hair soap, hair cleansing foam, hair oil, hair drier, hair preservative, hair dye, hair wave, hair bleach, hair gel, hair glaze, hair dresser, hair lacquer, hair moisturizer, Formulations of hair mousse or hairspray.

     Hereinafter, a method of obtaining the complex herbal extract of the present invention will be described in detail.

     Complex herbal extract of the present invention is washed, dried and shredded Bokyeong, Sewao, Baeksuo, Jihwang, Nasturtium, Ursula, Tosa and Bogolji, respectively, and the herbal composition ratio is Bokryeong: Shouao: Baeksuo: Chihwang: Hannyeoncho: Wooslung Earth and sand: golgol = 1-5: 1-5: 1-5: 1-5: 1-5: 1-5: 1-5: 1-5 weight ratio (w / w), preferably Fuyeong: Sewao: Baeksuo: Chihwang: Hanryulcho: Wooseul: Earthenware: Bogolji = 1-3: 1-3, 1-3, 1-3: 1-3, 1-3: 1-3, 1-3: weight ratio of 1-3 w / w), More preferably, Fuling: Shouo: Baeksuo: Chihwang: Nasturtium: Essence: Earthenware: Bogolji = 1-2: 1-2: 1-2: 1: 1-2: 1-2: 1: 1 : First step of mixing at a weight ratio (w / w) of 1; Water containing about 1 to 200 times (w / w), preferably 10 to 100 times (w / w) purified water, lower alcohols having 1 to 4 carbon atoms or mixed solvents thereof, preferably The addition of water for 1 hour to 10 hours, preferably 2 hours to 6 hours at 100 ℃ twice extraction method such as cold extraction, hot water extraction, ultrasonic extraction, reflux cooling extraction, preferably, by performing a hot water extraction method A second step of obtaining an extract; A third step of allowing the extract obtained in the above to stand at room temperature for about 12 hours to 48 hours, preferably 18 hours to 36 hours, for first cooling; 10 to 90% by weight of the solution, preferably 30 to 70% by weight of a lower alcohol having 1 to 4 carbon atoms, preferably ethanol, about 1 to 20 days, preferably 3 to 10 days A fourth step of allowing the mixture to cool at room temperature for secondary cooling; The crude herbal extract of the present invention can be obtained through the fifth step of preparing the filtrate by filtering the cooled solution.

     The present invention provides a cosmetic composition having an anti-hair loss, dandruff production, scalp pruritus improvement effect and hair growth promoting effect containing the complex herbal extract obtained by the above production method as an active ingredient.

     The complex herbal extract obtained by the extraction method was confirmed that the liver growth effect using the human body showed a hair growth effect.

     The composition having the hair loss prevention, dandruff production, scalp pruritic improvement and hair growth promoting effect of the present invention, 0.00001 to 50% by weight (w / w), preferably 0.0001 To 20% by weight (w / w), more preferably 0.1 to 5% by weight (w / w).

     However, the composition as described above is not necessarily limited thereto, and may vary according to the condition and the degree of progression of the patient.

     The composition of the present invention can be used in a variety of hair cosmetics having hair loss prevention, dandruff production inhibitory, scalp pruritic improvement and hair growth promoting effect. Examples of products to which the composition can be added include, for example, hair tonic, hair conditioner, hair essence, hair lotion, hair nutrition lotion, hair shampoo, hair rinse, hair treatment, hair cream, hair nutrition cream, hair Moisture Cream, Hair Massage Cream, Hair Wax, Hair Aerosol, Hair Pack, Hair Nutrition Pack, Hair Soap, Hair Cleansing Foam, Hair Oil, Hair Dryer, Hair Preservative, Hair Dye, Hair Wave, Hair Bleach, Hair Gel, Hair Glaze , Cosmetics such as hair dresser, hair lacquer, hair moisturizer, hair mousse or hair spray and the like.

Cosmetics of the present invention comprises a composition selected from the group consisting of water-soluble vitamins, oil-soluble vitamins, polymer peptides, polymer polysaccharides, sphingolipids and seaweed extract.

The water-soluble vitamins may be any compound that can be incorporated into cosmetics, but preferably vitamin B1, vitamin B2, vitamin B6, pyridoxine, pyridoxine, vitamin B12, pantothenic acid, nicotinic acid, nicotinic acid amide, folic acid, vitamin C, vitamin H, and the like. Their salts (thiamine hydrochloride, sodium ascorbate salt, etc.) and derivatives (ascorbic acid-2-sodium phosphate salt, ascorbic acid-2-magnesium phosphate salt, etc.) may also be used in the water-soluble vitamins that can be used in the present invention. Included. The water-soluble vitamins can be obtained by conventional methods such as microbial transformation, purification from microorganism culture, enzyme or chemical synthesis.

     The oil-soluble vitamin may be any compound that can be formulated into cosmetics, but preferably vitamin A, carotene, vitamin D2, vitamin D3, vitamin E (d1-alpha tocopherol, d-alpha tocopherol, d-alpha tocopherol), and the like. And derivatives thereof (ascorbic palmitate, ascorbic stearate, ascorbic acid dipalmitate, dl-alpha tocopherol acetate, dl-alpha tocopherol nicotinic acid, 6 vitamin E, DL-pantothenyl alcohol, D-pantotenyl alcohol, panto Tenyl ethyl ether, etc.) is also included in the oil-soluble vitamin used in the present invention. Oil-soluble vitamins can be obtained by conventional methods such as microbial transformation, purification of microorganism culture, enzyme or chemical synthesis.

     The polymeric peptide may be any compound as long as it can be compounded in cosmetics, and examples thereof include collagen, hydrolyzed collagen, gelatin, elastin, hydrolyzed elastin, and keratin. Polymeric peptides can be purified and obtained by conventional methods such as purification from microbial cultures, enzymatic methods or chemical synthesis methods, or can be purified and used from natural products such as dermis and pig silk such as pigs and cattle.

     The polymer polysaccharide may be any compound as long as it can be incorporated into cosmetics. Preferably, hydroxyethyl cellulose, xanthan gum, sodium hyaluronate, chondroitin sulfate or a salt thereof (sodium salt, etc.) may be mentioned. For example, chondroitin sulfate or its salt, etc. can be normally purified from a mammal or fish.

The sphingolipid may be any compound as long as it can be blended into cosmetics. Preferably, ceramide, phytosphingosine, sphingosaccharide lipid, etc. may be mentioned. Sphingo lipids can usually be purified from mammals, fish, shellfish, yeasts or plants by conventional methods or obtained by chemical synthesis.

     The seaweed extract may be any compound as long as it can be blended into cosmetics. Preferably, the seaweed extract may include brown algae extract, red algae extract, green algae extract, and the like. Also, calginine, arginic acid, sodium arginate, Potassium arginate and the like are also included in the seaweed extract used in the present invention. Seaweed extract can be obtained by purification from seaweed by conventional methods.

     In addition to the said essential component, you may mix | blend the cosmetics of this invention with the other components normally mix | blended with cosmetics as needed.

     Other components that may be added include fats and oils, moisturizers, emollients, surfactants, organic and inorganic pigments, organic powders, ultraviolet absorbers, preservatives, fungicides, antioxidants, plant extracts, pH adjusters, alcohols, pigments, flavorings, Blood circulation accelerators, cooling agents, restriction agents, purified water and the like.

     Examples of the fat or oil component include ester fats, hydrocarbon fats, silicone fats, fluorine fats, animal fats, and vegetable fats and oils.

As ester fats and oils, glyceryl tri2-ethylhexanoate, cetyl 2-ethylhexanoate, isopropyl myristate, butyl mystinate, isopropyl palmitate, ethyl stearate, octyl palmitate, isocetyl isostearate, and stearic acid Butyl, ethyl linoleate, isopropyl linoleate, ethyl oleate, isocetyl acid isocetyl, isostyl acid isostearyl, isostaryl palmitate, octylate acid octyldodecyl, isostearic acid isetyl, diethyl sebacate, adipine Acid isopropyl, isoalkyl neopentane, tri (capryl, capric acid) glyceryl, trimethyl ethyl trimethylol propane, triisostearic acid trimethylol propane, tetra 2-ethylhexanoic penta erythritol Cetyl caprylate, lauric acid decyl, hexyl laurate, decyl myristin, myristin acid myristyl, myritic acid cetyl, stearyl stearate, decyl oleate, rininooleic acid Isostearyl laurate, isotridecyl myristin, isocetyl palmitate, octyl stearate, octyl stearate, isocetyl stearate, isodecate oleate, octylate dodecyl oleate, octyl dodecyl linoleate, isopropyl isopropyl, 2- Cetostearyl ethylhexanoate, stearyl 2-ethylhexanoate, hexyl isostearate, ethylene glycol dioctanoate, ethylene glycol dioleate, propylene glycol dicapric acid, propylene glycol di (capryl, capric acid) propylene glycol, dicapryl Acid propylene glycol, dipentane neopentyl glycol, dioctanoate neopentyl glycol, tricaprylate glyceryl, triundecyl glyceryl, triisopalmitate glyceryl, triisostearic acid glyceryl neopentane dodecyl, Isostearyl octanoate, octyl isononate, hexyldecyl neodecanoate, octyldodecyl neodecanoate, isocetyl isostearate, isstearyl isostearate, Sothete octylate, polyglycerol oleate, polyglycerine isostearate, triisocetyl citrate, triisoalkyl citrate, triisooctyl citrate, lauryl lactate, myritic lactate, octyl lactate, octyl lactate Ethyl, acetyl triethyl citrate, acetyl tributyl citrate, trioctyl citrate, diisostearyl malic acid, 2-ethylhexyl hydroxystearate, di2-ethylhexyl succinate, diisobutyl adipicate, diisopropyl sebacinate, Dioctyl sebacate, cholesteryl stearate, cholesteryl isostearate, cholesteryl hydroxystearate, cholesteryl oleate, dihydrocholesteryl oleate, physteryl isostearate, phytic oleate, 12-Steloylhydroxystearate isocetyl, 12-Steloylhydroxystearate stearyl, 12-steal One hydroxy stearic acid and the like esters such as cetearyl source.

Examples of the hydrocarbon-based oils and fats include hydrocarbon oils such as squalene, liquid paraffin, alpha-olefin oligomers, isoparaffins, ceresin, paraffins, liquid isoparaffins, polybutenes, microcrystalline waxes, and vaseline.

Examples of the silicone-based oils and fats include polymethylsilicone, methylphenylsilicone, methylcyclopolysiloxane, octamethylpolysiloxane, decamethylpolysiloxane, dodecamethylcyclosiloxane, dimethylsiloxane, methylcetyloxysiloxane copolymer, dimethylsiloxane and methylsteoxysiloxane copolymer, and alkyl. Modified silicone oil, amino modified silicone oil and the like.

Examples of the fluorine-based oil include perfluoropolyether and the like.

Animal or vegetable oils include avocado oil, almond oil, olive oil, sesame oil, rice bran oil, soybean oil, soybean oil, corn oil, rapeseed oil, almond oil, palm kernel oil, palm oil, castor oil, sunflower oil, grape seed oil. , Cottonseed oil, Palm oil, Cucumber nut oil, Wheat germ oil, Rice germ oil, Shea butter, Walnut colostrum oil, Marker demia nut oil, Meadow home oil, Egg yolk oil, Uji, Horse oil, Mink oil, Orange rape oil, Jojoba oil And animal or plant fats and oils such as candeler wax, carnava wax, liquid lanolin and hardened castor oil.

Examples of the moisturizing agent include a water-soluble low molecular moisturizer, a fat-soluble molecular moisturizer, a water-soluble polymer, and a fat-soluble polymer.

Water-soluble low molecular humectants include serine, glutamine, sorbitol, mannitol, pyrrolidone-sodium carboxylate, glycerin, propylene glycol, 1,3-butylene glycol, ethylene glycol, polyethylene glycol B (polymerization degree n = 2 or more), polypropylene Glycol (polymerization degree n = 2 or more), polyglycerol B (polymerization degree n = 2 or more), lactic acid, lactic acid salt, etc. are mentioned.

Examples of fat-soluble low molecular humectants include cholesterol and cholesterol esters.

Examples of the water-soluble polymer include carboxyvinyl polymer, polyasparaginate, tragacanth, xanthan gum, methyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, water soluble chitin, chitosan, and dextrin. Can be.

Examples of the fat-soluble polymers include polyvinylpyrrolidone-eicosene copolymers, polyvinylpyrrolidone-hexadecene copolymers, nitrocellulose, dextrin fatty acid esters, polymer silicones, and the like.

Examples of the emollient include long-chain acyl glutamic acid cholesteryl esters, hydroxy stearic acid cholesterol, 12-hydroxystearic acid, stearic acid, rosin acid, lanolin fatty acid cholesteryl esters, and the like.

As surfactant, nonionic surfactant, anionic surfactant, cationic surfactant, amphoteric surfactant, etc. are mentioned.

As nonionic surfactant, self-emulsifying glycerin monostearate, propylene glycol fatty acid ester, glycerin fatty acid ester, polyglycerol fatty acid ester, sorbitan fatty acid ester, POE (polyoxyethylene) sorbitan fatty acid ester, POE sorbitan fatty acid ester, POE Glycerin Fatty Acid Ester, POE Alkyl Ether, POE Fatty Acid Ester, POE Cured Castor Oil, POE Castor Oil, POE / POP (Polyoxyethylene / Polyoxypropylene) Copolymer, POE / POP Alkyl Ether, Polyether Modified Silicone, Laurin Acid Alkanolamide, alkylamine oxide, hydrogenated soybean phospholipid, etc. are mentioned.

Anionic surfactants include fatty acid soaps, alpha-acyl sulfonates, alkyl sulfonates, alkyl allyl sulfonates, alkyl naphthalene sulfonates, alkyl sulfates, POE alkyl ether sulfates, alkylamide sulfates, alkyl phosphates, POE alkylphosphates, and alkylamides. Phosphates, alkyloylalkyltaurine salts, N-acylamino acid salts, POE alkyl ether carboxylate salts, alkyl sulfosuccinate salts, sodium alkyl sulfo acetates, acylated hydrolyzed collagen peptide salts, perfluoroalkyl phosphate esters, and the like. have.

As cationic surfactant, alkyl trimethylammonium chloride, stearyl trimethyl ammonium chloride, stearyl trimethyl ammonium chloride, cetostearyl trimethyl ammonium chloride, distearyl dimethyl ammonium chloride, stearyl dimethyl benzyl ammonium bromide, behenyl trimethyl ammonium chloride, chloride Benzalkonium, diethylaminoethyl stearate, dimethylaminopropyl stearate, lanolin derivatives, quaternary ammonium salts, and the like.

Examples of amphoteric surfactants include the carboxybetaine type, the amide betain type, the sulfobetain type, the hydroxysulfobetain type, the amide sulfobetain type, the phosphobetaine type, the aminocarboxylate type, the imidazoline derivative type, and the amideamine type. An amphoteric surfactant etc. are mentioned.

Examples of the organic and inorganic pigments include inorganic pigments such as silicic acid, silicic anhydride, magnesium silicate, talc, sericite, mica, kaolin, Bengala, clay, bentonite, titanium mica, titanium oxide, bismuth chloride, zirconium oxide, magnesium oxide, Inorganic pigments such as calcium sulfate, barium sulfate, magnesium sulfate, calcium carbonate, magnesium carbonate, iron oxide, chromium oxide, chromium oxide, chromium hydroxide, Polyamide, Polyester, Polypropylene, Polystyrene, Polyurethane, Vinyl Resin, Urea Resin, Phenolic Resin, Fluoro Resin, Silicon Resin, Acryl Resin, Melamine Resin, Epoxy Resin, Polycarbonate Resin, Divinylbenzene, Styrene Copolymer And organic pigments such as silk powder, cellulose, CI pigment yellow, and CI pigment orange, and composite pigments of these inorganic pigments and organic pigments.

As organic powder, Metal soaps, such as a calcium stearate; Alkyl phosphate metal salts such as sodium cetylinate, zinc lauryl acid and calcium laurate; Acylamino acid polyvalent metal salts such as N-lauroyl-beta-alanine calcium, N-lauroyl-beta-alanine zinc, and N-lauroylglycine calcium; Amide sulfonic acid polyvalent metal salts, such as N-lauroyl-taurine calcium and N-palmitoyl-taurine calcium; N-epsilon-lauroyl-L-lysine, N-epsilon-palmitolyzine, N-alpha-paratoylol nitin, N-alpha-lauroyl arginine, N-alpha-cured fatty acid acyl arginine -Acyl basic amino acid; N-acyl polypeptides, such as N-lauroyl glycyl glycine; Alpha-amino fatty acids such as alpha-aminocaprylic acid and alpha-aminolauric acid; Polyethylene, polypropylene, nylon, polymethyl methacrylate, polystyrene, divinylbenzene-styrene copolymer, ethylene tetrafluoride and the like.

Examples of the ultraviolet absorber include paraaminobenzoic acid, ethyl paraaminobenzoate, amyl paraaminobenzoic acid, octyl paraaminobenzoate, ethylene glycol salicylate, phenyl salicylate, octyl salicylate, benzyl salicylate, butylphenyl salicylate, homomentyl salicylic acid and benzyl cinnamic acid. , Paramethoxy cinnamic acid-2-ethoxyethyl, paramethoxy cinnamic acid octyl, diparamethoxy cinnamic acid mono-2-ethylhexaneglyceryl, paramethoxy cinnamic acid isopropyl, diisopropyl diisopropyl cinnamic acid ester mixture, wuro Canonic acid, ethyl urokanoate, hydroxymethoxybenzophenone, hydroxymethoxybenzophenonesulfonic acid and salts thereof, dihydroxymethoxybenzophenone, dihydroxymethoxybenzophenone sodium disulfonate, dihydroxybenzophenone , Tetrahydroxybenzophenone, 4- tert -butyl-4'-methoxydibenzoylmethane, 2,4,6-trianilino- p- (carbo-2'-ethylhexyl-1'-oxy) -1 , 3,5-triazine, 2- (2-hi And the like can be mentioned hydroxy-5-methylphenyl) benzotriazole.

As fungicides, hinokithiol, trichloric acid, trichlorohydroxydiphenyl ether, chlorhexidine gluconate, phenoxyethanol, resorcin, isopropylmethylphenol, azulene, salicylic acid, ginxitlionone, benzalkonium chloride, photosensitive Sodium No. 301, sodium mononitrohydrol, undecylenic acid, and the like.

Examples of the antioxidant include butylhydroxyanisole, propyl gallic acid, and erythorbic acid.

     Examples of the pH adjuster include citric acid, sodium citrate, malic acid, sodium malate, fmaric acid, sodium pmarate, succinic acid, sodium succinate, sodium hydroxide, sodium dihydrogen phosphate, and the like.

Examples of the alcohol include higher alcohols such as cetyl alcohol.

In addition, the compounding component which may be added other than this is not limited to this, Although any said component can be mix | blended within the range which does not impair the objective and effect of this invention, Preferably it is 0.01 to 5% weight percentage with respect to a total weight, More Preferably 0.01 to 3% by weight.

The cosmetic of the present invention may take the form of a solution, an emulsion, a viscous mixture, or the like.

Components included in the cosmetic composition of the present invention may include components commonly used in cosmetic compositions in addition to the complex herbal extract as an active ingredient, for example, such as stabilizers, solubilizers, vitamins, pigments and flavorings Phosphorus aids and carriers.

     The cosmetic composition of the present invention may be prepared in any formulation commonly prepared in the art, and includes, for example, milky lotion, cream, lotion, pack, foundation, lotion, essence, hair cosmetic, and the like.

     When the formulation of the present invention is a paste, cream or gel, animal carriers, vegetable fibers, waxes, paraffins, starches, tracantes, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicas, talc or zinc oxide, etc. may be used as carrier components. Can be.

     In the case where the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. Especially, in the case of a spray, a mixture of chlorofluorohydrocarbons, propane / Propane or dimethyl ether.

     When the formulation of the present invention is a solution or emulsion, a solvent, solvating or emulsifying agent is used as the carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 Fatty acid esters of, 3-butylglycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan.

     When the dosage form of the present invention is a suspension, liquid carrier diluents such as water, ethanol or propylene glycol, suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystalline Cellulose, aluminum metahydroxy, bentonite, agar or tracant and the like can be used.

     When the formulation of the present invention is a surfactant-containing cleansing, the carrier component is an aliphatic alcohol sulfate, an aliphatic alcohol ether sulfate, a sulfosuccinic acid monoester, an isethionate, an imidazolinium derivative, a methyltaurate, a sarcosinate, a fatty acid amide. Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, linolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.

      The composition for preventing hair loss and promoting hair growth containing complex herbal extracts of Bokryeong, sewage, baeksuo, jihwang, nasturtium, dew, earth and sand and golgol of the present invention has no side effects or toxicity to the human body, and hair loss through a simple clinical trial. It is effective in preventing, preventing dandruff, improving scalp pruritus and promoting hair growth, and can be usefully used as a cosmetic composition exhibiting hair loss prevention, preventing dandruff, improving scalp pruritus and promoting hair growth.

Hereinafter, the present invention will be described in detail with reference to the following examples and experimental examples.

However, the following Examples and Experimental Examples are merely illustrative of the present invention, and the content of the present invention is not limited by the following Examples and Experimental Examples.

Example 1. Preparation of Complex Herbal Extract

900g Baekbokyeong purchased from Gyeongdong Market, 900g of Red Sewage, 900g of BaekSuo, 900g of Guernsey, 900g, 900g of Hannyeoncho, 450g of dew, 450g of Tosa, 450g of Bogolji and 450g of Bogolji, washed, dried and cut into a mechanical shaker. After repeated extracting twice at 100 ° C. for 4 hours to obtain a hot water extract, the extract was left to stand at room temperature for 24 hours to cool, and then 3 kg of ethanol corresponding to 30 to 70% by weight of the extract solution was added. . After leaving the extract for another week, the filtrate was filtered with filter paper (hereinafter, referred to as "KYE1 extract"), and used as a sample of the following experimental example.

Example 2 Preparation of Shampoo Composition

In order to compare the efficacy of the KYE1 extract of the present invention with the comparative example shampoo composition (no sample), a shampoo composition was prepared as follows.

Shampoo Cosmetic Composition (Unit: wt%) Raw material name Comparative example Example Triethanolamine Laurylsulfate 40.0 40.0 Lauryl Hydroxysorbate 12.0 12.0 glycerin 2.0 2.0 Polyquaternium-7 0.3 0.3 antiseptic Quantity Quantity Spices Quantity Quantity Zinc pyrithione solution (50%) 2.1 2.1 Nicotinic acid amide 0.3 0.3 KYE1 Extract - 3.0 Purified water Balance Balance Sum 100.0 100.0

Experimental Example 1. Measurement of the effect of inhibiting itching and dandruff production of the scalp

     In order to measure the scalp itching and dandruff production inhibitory effect of the shampoo composition obtained in the above example was performed as follows.

     Shampoo cosmetics were used once daily for 20 male and female subjects with dandruff and itching. After 2 months of use, the effect of eliminating itching and inhibiting dandruff production was observed according to the following determination method.

Remove the itching of the scalp and
Dandruff production inhibitory effect Comparative example Example 2 Very good 0 2 Great One 6 In a little 6 8 none 13 4

Experimental Example 2. Measurement of hair loss prevention effect

     In order to measure the hair loss prevention effect of the shampoo composition obtained in the above Example was performed as follows.

     Twenty male and female subjects who felt that they had a normal hair loss were asked to use a shampoo cosmetic once a day. After using for 2 months, the degree of hair loss prevention was measured according to the following determination method. (See Figs. 1 and 2).

Hair loss prevention effect Comparative example Example Very good 0 3 Great One 4 In a little 4 6 none 15 7

Experimental Example 3. Measurement of the Number of Hair Loss

     In order to measure the number of hair loss of the shampoo compositions obtained in the above example, the experiment was performed as follows.

    In order to determine the hair loss prevention effect of the shampoo products prepared according to the above Examples and Comparative Examples was applied to 20 healthy 40-50 adults. The number of hair loss was checked by combing after 5 days of product use.

Number of hair loss () Comparative example Example 0-1 0 0 2-4 0 One 5-6 0 2 7-9 3 7 more than 10 17 10

Shampoo containing KYE1 extract consisting of Baekbokryeong, Sewao, Baeksuo, Jihwang, Hannyeoncho, Emulsion, Tosa and Bulgogi for the effects of inhibiting itching and dandruff production and hair loss of the scalp as shown in Table 2, Table 3 and Table 4 The product showed an excellent effect compared to the existing shampoo products. In other words, the effects of KYE1 extract consisting of Baekbokryeong, Sewao, Baeksuo, Jihwang, Hanryok, Woo Seol, Tosa, Bogolji are effective in preventing hair loss, improving scalp itch, and preventing dandruff. there was.

Experimental Example 4. Skin irritation test

     In order to perform the skin irritation test of the shampoo composition obtained in the above example, the experiment was performed as follows.

     In order to examine the skin irritation of KYE1 extract, a sample (approximately 2.0 g) of each sample was buried in a hazel chamber for 48 hours in a group of 20 men and women in their late 30s to late 40s. After 4 hours of removing the hazel chamber, the skin condition was visually read.

sample Number of test subjects Judgment result A B C D Purified water 20 19 One 0 0 KYE1 Extract 20 18 2 0 0 Iris extract 20 17 2 One 0 Bokbokyeong Extract 20 18 2 0 0 Propylene glycol 20 16 2 2 0 Sodium Lauryl Sulfate Liquid 20 12 4 3 One * Judgment Table
A: No erythema or unusual symptoms
B: slightly reddened
C: redness
D: Severe redness and swelling

As shown in Table 5, propylene glycol, a polyhydric alcohol, and sodium lauryl sulfate solution, an anionic surfactant, showed severe skin irritation, whereas KYE1 extract, sewage extract, and Baekbokryeong extract were almost identical to purified water. No irritation was shown. These results show that KYE1 extract has excellent skin safety.

   In the present specification, a few examples of various manufacturing and analysis experiments performed by the inventors have been described as an example, and the technical idea of the present invention is not limited thereto and may be variously applied.

Hereinafter, the preparation examples of the composition including the extract of the present invention, but the present invention is not intended to limit it, but is intended to explain in detail only.

Formulation Example 1 Preparation of Hair Tonic

Resorcinol 0.1%

Menthol 0.05%

Panthenol 0.2%

Salicylic Acid 0.1%

Tocopheryl Acetate 0.1%

Pyridoxine hydrochloride 0.1%

Castor Oil 5.0%

KYE1 Extract 10.0%

Pigment amount

Spices

Ethanol

Purified water level

Total 100.0%

Formulation Example 2 Preparation of Hair Conditioner

Cetanol 3.5%

Self-emulsifying glycerin monostearate 1.5%

Propylene Glycol 2.5%

Stearylmethylbenzyl Ammonium Chloride (25%) 7.0%

0.3% methyl paraoxybenzoate

KYE1 Extract 2.5%

Pigment amount

Spices

Purified water level

Total 100.0%

Formulation Example 3 Preparation of Hair Lotion

Resorcinol 2.0%

Menthol 2.0%

Panthenol 0.5%

Pyroctonolamine 0.1%

KYE1 Extract 5.0%

Fragrance, pigment 0.5%

Purified water level

Total 100.0%

Formulation Example 4 Preparation of Hair Soap

KYE1 Extract 0.1%

Titanium dioxide 0.2%

Polyethylene Glycol 0.8%

Glycerin 0.5%

Ethylenediaminetetraacetic Acid 0.05%

Sodium 1.0%

Pigment amount

Soap flavor

Cosmetic soap base (13% moisture, parts by weight)

Total 100.0%

Figure 1 shows a photograph of the human hair before using the shampoo cosmetic of the present invention;

Figure 2 shows a human hair photograph after using the shampoo cosmetic of the present invention.

Claims (8)

      Cosmetic composition having anti-hair loss and hair growth promoting effect containing a complex herbal extract of Bokryeong, sewage, baeksuo, jihwang, nasturtium, hyssop, earth and sand, Bogolji as an active ingredient.       According to claim 1, wherein the compound herbal extract is a compounding ratio of Bokryeong: Sewao: Baeksuo: Chihwang: Nasturtium: Emulsion: Earthenware: Bogolji = 1-5: 1-5: 1-5: 1-5: 1 ~ 5: 1-5: 1-5: The cosmetic composition characterized by the weight ratio (w / w) of 1-5. The method of claim 1, The extract is a cosmetic composition which is an extract available in water, including purified water, lower alcohol having 1 to 4 carbon atoms or a mixed solvent thereof. The method of claim 1, The cosmetic composition, characterized in that using the baekryokyeong or red bokyeongyeong. The method of claim 1, The sulfuric acid is a cosmetic composition, characterized in that the use of dried sulfur, dried sulfur, or raw sulfur. The method of claim 1, The cosmetic composition is a hair tonic, hair conditioner, hair essence, hair lotion, hair nutrition lotion, hair shampoo, hair rinse, hair treatment, hair cream, hair nutrition cream, hair moisturizing cream, hair massage cream, hair wax, hair aerosol , Hair pack, nourishment pack, hair soap, hair cleansing foam, hair oil, hair drier, hair preservative, hair dye, hair wave, hair bleach, hair gel, hair glaze, hair dresser, hair lacquer, hair moisturizer, Cosmetic composition which is a formulation of hair mousse or hair spray. The cosmetic composition of claim 1 comprising 0.00001 to 50% by weight (w / w) of the complex herbal extract based on the total weight of the composition. Bokryeong, Sewao, Baeksuo, Jihwang, Hannyeoncho, Wooseul, Tosa and Bogolji, respectively. 5: 1-5: 1-5: 1-5: 1-5: 1-5: 1-5: 1-5: 1st step of mixing in the weight ratio (w / w) of 1-5; Cold extract, hot water twice at 100 ° C. for 1 hour to 10 hours by adding water containing about 1 to 200 times (w / w) purified water, a lower alcohol having 1 to 4 carbon atoms or a mixed solvent thereof A second step of obtaining an extract by performing an extraction method such as extraction, ultrasonic extraction, reflux cooling extraction, and the like; A third step of allowing the extract obtained above to be cooled at room temperature for about 12 to 48 hours; A fourth step of adding 10 to 90% by weight of a lower alcohol solvent having 1 to 4 carbon atoms in the weight of the solution and leaving it at room temperature for about 1 to 20 days for secondary cooling; The method for preparing the complex herbal extract of claim 1 comprising a fifth step of filtering the cooled solution to obtain a filtrate and freeze drying and concentrating it.

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