KR20110063457A - 대상에서의 지속적 치료 약물 농도 달성을 위한 조성물 및 방법 - Google Patents

대상에서의 지속적 치료 약물 농도 달성을 위한 조성물 및 방법 Download PDF

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Publication number
KR20110063457A
KR20110063457A KR1020117005982A KR20117005982A KR20110063457A KR 20110063457 A KR20110063457 A KR 20110063457A KR 1020117005982 A KR1020117005982 A KR 1020117005982A KR 20117005982 A KR20117005982 A KR 20117005982A KR 20110063457 A KR20110063457 A KR 20110063457A
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KR
South Korea
Prior art keywords
prodrug
days
administering
administration
irinotecan
Prior art date
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Ceased
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KR1020117005982A
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English (en)
Korean (ko)
Inventor
마이클 에이 엘든
시바니 에스 해리트
탐라 엘 바커
Original Assignee
넥타르 테라퓨틱스
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Application filed by 넥타르 테라퓨틱스 filed Critical 넥타르 테라퓨틱스
Publication of KR20110063457A publication Critical patent/KR20110063457A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
KR1020117005982A 2008-09-23 2009-09-23 대상에서의 지속적 치료 약물 농도 달성을 위한 조성물 및 방법 Ceased KR20110063457A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US9951608P 2008-09-23 2008-09-23
US61/099,516 2008-09-23
US10693108P 2008-10-20 2008-10-20
US61/106,931 2008-10-20
US17343309P 2009-04-28 2009-04-28
US61/173,433 2009-04-28

Publications (1)

Publication Number Publication Date
KR20110063457A true KR20110063457A (ko) 2011-06-10

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020117005982A Ceased KR20110063457A (ko) 2008-09-23 2009-09-23 대상에서의 지속적 치료 약물 농도 달성을 위한 조성물 및 방법

Country Status (21)

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US (3) US8906353B2 (cg-RX-API-DMAC7.html)
EP (1) EP2349346B1 (cg-RX-API-DMAC7.html)
JP (3) JP2012503602A (cg-RX-API-DMAC7.html)
KR (1) KR20110063457A (cg-RX-API-DMAC7.html)
CN (1) CN102164617A (cg-RX-API-DMAC7.html)
AU (1) AU2009297091B2 (cg-RX-API-DMAC7.html)
CA (1) CA2736939C (cg-RX-API-DMAC7.html)
CY (1) CY1122208T1 (cg-RX-API-DMAC7.html)
DK (1) DK2349346T3 (cg-RX-API-DMAC7.html)
ES (1) ES2744975T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20192120T1 (cg-RX-API-DMAC7.html)
HU (1) HUE047352T2 (cg-RX-API-DMAC7.html)
IL (1) IL211888A (cg-RX-API-DMAC7.html)
LT (1) LT2349346T (cg-RX-API-DMAC7.html)
MX (1) MX2011003063A (cg-RX-API-DMAC7.html)
PL (1) PL2349346T3 (cg-RX-API-DMAC7.html)
PT (1) PT2349346T (cg-RX-API-DMAC7.html)
RS (1) RS59607B1 (cg-RX-API-DMAC7.html)
SI (1) SI2349346T1 (cg-RX-API-DMAC7.html)
SM (1) SMT201900609T1 (cg-RX-API-DMAC7.html)
WO (1) WO2010036335A1 (cg-RX-API-DMAC7.html)

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EP2349346B1 (en) 2008-09-23 2019-08-28 Nektar Therapeutics Method of metronomic dosing with camptothecin prodrugs (e.g. peg-irinotecan)
ES2779225T3 (es) * 2011-04-08 2020-08-14 Sphaera Pharma Pte Ltd Reactivos de merilformilo sustituido y procedimiento de uso de los mismos para modificar propiedades fisicoquímicas y/o farmacocinéticas de compuestos
JP6284541B2 (ja) * 2012-11-28 2018-02-28 ネクター セラピューティクス 長時間作用型トポイソメラーゼｉ阻害薬による乳癌治療の有効性を評価及び予測する方法
CA2976912A1 (en) * 2015-02-17 2016-08-25 Mallinckrodt Llc Modified docetaxel liposome formulations and uses thereof
CA3026144A1 (en) 2016-06-02 2017-12-07 Innopharmax, Inc. Metronomic oral gemcitabine for cancer therapy
CN106539557A (zh) * 2016-10-08 2017-03-29 西安交通大学 一种基于恒速静脉输入的药代动力学参数的测定方法
AU2019344783B2 (en) 2018-09-17 2025-10-23 The Children's Hospital Of Philadelphia Polymer-based macromolecular prodrugs
US20240156808A1 (en) * 2021-02-23 2024-05-16 Edison Oncology Compositions and methods to improve the therapeutic benefit of suboptimally chemical compounds and biological therapies including substituted camptothecins such as irinotecan and topotecan for the treatment of benign and neoplastic hyperproliferative disease conditions, infections, inflammatory and immunological diseases
CN115317486B (zh) * 2022-08-17 2024-04-19 南昌大学 一种共载紫杉醇和伊立替康前药纳米制剂及其制备方法

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Also Published As

Publication number Publication date
EP2349346B1 (en) 2019-08-28
PL2349346T3 (pl) 2020-03-31
JP2016216510A (ja) 2016-12-22
CN102164617A (zh) 2011-08-24
CA2736939A1 (en) 2010-04-01
US20180028525A1 (en) 2018-02-01
HUE047352T2 (hu) 2020-04-28
AU2009297091A1 (en) 2010-04-01
IL211888A0 (en) 2011-06-30
ES2744975T3 (es) 2020-02-27
SI2349346T1 (sl) 2019-12-31
DK2349346T3 (da) 2019-10-07
LT2349346T (lt) 2019-09-25
EP2349346A1 (en) 2011-08-03
US9801873B2 (en) 2017-10-31
IL211888A (en) 2015-08-31
US8906353B2 (en) 2014-12-09
US20150087668A1 (en) 2015-03-26
CA2736939C (en) 2021-09-14
RS59607B1 (sr) 2020-01-31
SMT201900609T1 (it) 2020-01-14
JP6076317B2 (ja) 2017-02-08
PT2349346T (pt) 2019-10-24
US20110269789A1 (en) 2011-11-03
WO2010036335A1 (en) 2010-04-01
MX2011003063A (es) 2011-04-21
AU2009297091B2 (en) 2015-03-05
JP2012503602A (ja) 2012-02-09
JP2015034180A (ja) 2015-02-19
CY1122208T1 (el) 2020-11-25
US10525051B2 (en) 2020-01-07
HRP20192120T1 (hr) 2020-02-21

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