CA2736939C - Means of achieving sustained-therapeutic sn-38 concentrations in a subject - Google Patents
Means of achieving sustained-therapeutic sn-38 concentrations in a subject Download PDFInfo
- Publication number
- CA2736939C CA2736939C CA2736939A CA2736939A CA2736939C CA 2736939 C CA2736939 C CA 2736939C CA 2736939 A CA2736939 A CA 2736939A CA 2736939 A CA2736939 A CA 2736939A CA 2736939 C CA2736939 C CA 2736939C
- Authority
- CA
- Canada
- Prior art keywords
- prodrug
- days
- irinotecan
- cancer
- dose
- Prior art date
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Classifications
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- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (7)
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| US61/099,516 | 2008-09-23 | ||
| US10693108P | 2008-10-20 | 2008-10-20 | |
| US61/106,931 | 2008-10-20 | ||
| US17343309P | 2009-04-28 | 2009-04-28 | |
| US61/173,433 | 2009-04-28 | ||
| PCT/US2009/005284 WO2010036335A1 (en) | 2008-09-23 | 2009-09-23 | Compositions and methods for achieving sustained therapeutic drug concentrations in a subject |
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| CA2736939A1 CA2736939A1 (en) | 2010-04-01 |
| CA2736939C true CA2736939C (en) | 2021-09-14 |
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| CA2736939A Active CA2736939C (en) | 2008-09-23 | 2009-09-23 | Means of achieving sustained-therapeutic sn-38 concentrations in a subject |
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| EP2349346B1 (en) | 2008-09-23 | 2019-08-28 | Nektar Therapeutics | Method of metronomic dosing with camptothecin prodrugs (e.g. peg-irinotecan) |
| ES2779225T3 (es) * | 2011-04-08 | 2020-08-14 | Sphaera Pharma Pte Ltd | Reactivos de merilformilo sustituido y procedimiento de uso de los mismos para modificar propiedades fisicoquímicas y/o farmacocinéticas de compuestos |
| JP6284541B2 (ja) * | 2012-11-28 | 2018-02-28 | ネクター セラピューティクス | 長時間作用型トポイソメラーゼｉ阻害薬による乳癌治療の有効性を評価及び予測する方法 |
| CA2976912A1 (en) * | 2015-02-17 | 2016-08-25 | Mallinckrodt Llc | Modified docetaxel liposome formulations and uses thereof |
| CA3026144A1 (en) | 2016-06-02 | 2017-12-07 | Innopharmax, Inc. | Metronomic oral gemcitabine for cancer therapy |
| CN106539557A (zh) * | 2016-10-08 | 2017-03-29 | 西安交通大学 | 一种基于恒速静脉输入的药代动力学参数的测定方法 |
| AU2019344783B2 (en) | 2018-09-17 | 2025-10-23 | The Children's Hospital Of Philadelphia | Polymer-based macromolecular prodrugs |
| US20240156808A1 (en) * | 2021-02-23 | 2024-05-16 | Edison Oncology | Compositions and methods to improve the therapeutic benefit of suboptimally chemical compounds and biological therapies including substituted camptothecins such as irinotecan and topotecan for the treatment of benign and neoplastic hyperproliferative disease conditions, infections, inflammatory and immunological diseases |
| CN115317486B (zh) * | 2022-08-17 | 2024-04-19 | 南昌大学 | 一种共载紫杉醇和伊立替康前药纳米制剂及其制备方法 |
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| AU4406793A (en) | 1992-06-04 | 1993-12-30 | Clover Consolidated, Limited | Water-soluble polymeric carriers for drug delivery |
| US5614549A (en) | 1992-08-21 | 1997-03-25 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US5880131A (en) | 1993-10-20 | 1999-03-09 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US5840900A (en) | 1993-10-20 | 1998-11-24 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US5965566A (en) | 1993-10-20 | 1999-10-12 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US5919455A (en) | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5605976A (en) | 1995-05-15 | 1997-02-25 | Enzon, Inc. | Method of preparing polyalkylene oxide carboxylic acids |
| TW438775B (en) | 1995-04-07 | 2001-06-07 | Pharmacia & Upjohn Co Llc | Novel intermediates and process for the manufacture of camptothecin derivatives (CPT-11) and related compounds |
| US5726181A (en) | 1995-06-05 | 1998-03-10 | Bionumerik Pharmaceuticals, Inc. | Formulations and compositions of poorly water soluble camptothecin derivatives |
| SG50747A1 (en) | 1995-08-02 | 1998-07-20 | Tanabe Seiyaku Co | Comptothecin derivatives |
| ATE314843T1 (de) | 1996-03-12 | 2006-02-15 | Pg Txl Co Lp | Wasserlösliche paclitaxel-prodrogen |
| US6011042A (en) | 1997-10-10 | 2000-01-04 | Enzon, Inc. | Acyl polymeric derivatives of aromatic hydroxyl-containing compounds |
| US6111107A (en) | 1997-11-20 | 2000-08-29 | Enzon, Inc. | High yield method for stereoselective acylation of tertiary alcohols |
| US6153655A (en) | 1998-04-17 | 2000-11-28 | Enzon, Inc. | Terminally-branched polymeric linkers and polymeric conjugates containing the same |
| JP2002542304A (ja) | 1999-04-28 | 2002-12-10 | ベクトレイムド インコーポレイテッド | 酵素的に活性化された重合薬物接合体 |
| WO2000066125A1 (en) | 1999-04-29 | 2000-11-09 | Aventis Pharma S.A. | Method for treating cancer using camptothecin derivatives and 5-fluorouracil |
| JP4861586B2 (ja) | 1999-12-22 | 2012-01-25 | ネクター セラピューティックス | 水溶性ポリマーの立体的に妨害される誘導体 |
| WO2001062299A2 (en) | 2000-02-28 | 2001-08-30 | Shearwater Corporation | Water-soluble polymer conjugates of artelinic acid |
| US6629995B1 (en) | 2000-03-31 | 2003-10-07 | Super Gen, Inc. | Camptothecin conjugates |
| WO2002008789A2 (en) | 2000-07-21 | 2002-01-31 | Services Petroliers Schlumberger | Nuclear magnetic resonance methods for extracting information about a fluid in a rock |
| JP2004514701A (ja) | 2000-11-30 | 2004-05-20 | ネクター セラピューティクス エーエル，コーポレイション | トリアジン誘導体の水溶性ポリマー複合体 |
| TWI246524B (en) | 2001-01-19 | 2006-01-01 | Shearwater Corp | Multi-arm block copolymers as drug delivery vehicles |
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| EP1441772A2 (en) | 2001-10-29 | 2004-08-04 | Nektar Therapeutics Al, Corporation | Polymer conjugates of protein kinase c inhibitors |
| CA2464346A1 (en) | 2001-10-30 | 2003-05-08 | Nektar Therapeutics Al, Corporation | Water-soluble polymer conjugates of retinoic acid |
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| US6608076B1 (en) | 2002-05-16 | 2003-08-19 | Enzon, Inc. | Camptothecin derivatives and polymeric conjugates thereof |
| BR0312685A (pt) | 2002-06-06 | 2005-09-06 | Univ Washington | Métodos de utilização de compostos do tipo artemisinina para prevenir ou retardar o aparecimento de cancêr |
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| US7462627B2 (en) * | 2006-02-09 | 2008-12-09 | Enzon Pharmaceuticals, Inc. | Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers |
| CN101421282B (zh) * | 2006-02-17 | 2013-08-14 | 俄勒冈州由俄勒冈州立大学代表高等教育委员会行使 | 用长春花生物碱n-氧化物和类似物治疗过度增殖性疾病 |
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| CN101199857B (zh) * | 2007-12-12 | 2011-04-13 | 中国药科大学 | mPEG-PLA-喜树碱类药物的结合物 |
| EP2349346B1 (en) | 2008-09-23 | 2019-08-28 | Nektar Therapeutics | Method of metronomic dosing with camptothecin prodrugs (e.g. peg-irinotecan) |
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| EP2349346B1 (en) | 2019-08-28 |
| PL2349346T3 (pl) | 2020-03-31 |
| JP2016216510A (ja) | 2016-12-22 |
| CN102164617A (zh) | 2011-08-24 |
| CA2736939A1 (en) | 2010-04-01 |
| US20180028525A1 (en) | 2018-02-01 |
| HUE047352T2 (hu) | 2020-04-28 |
| AU2009297091A1 (en) | 2010-04-01 |
| IL211888A0 (en) | 2011-06-30 |
| ES2744975T3 (es) | 2020-02-27 |
| SI2349346T1 (sl) | 2019-12-31 |
| DK2349346T3 (da) | 2019-10-07 |
| LT2349346T (lt) | 2019-09-25 |
| EP2349346A1 (en) | 2011-08-03 |
| US9801873B2 (en) | 2017-10-31 |
| IL211888A (en) | 2015-08-31 |
| US8906353B2 (en) | 2014-12-09 |
| US20150087668A1 (en) | 2015-03-26 |
| RS59607B1 (sr) | 2020-01-31 |
| SMT201900609T1 (it) | 2020-01-14 |
| JP6076317B2 (ja) | 2017-02-08 |
| PT2349346T (pt) | 2019-10-24 |
| US20110269789A1 (en) | 2011-11-03 |
| WO2010036335A1 (en) | 2010-04-01 |
| MX2011003063A (es) | 2011-04-21 |
| AU2009297091B2 (en) | 2015-03-05 |
| JP2012503602A (ja) | 2012-02-09 |
| JP2015034180A (ja) | 2015-02-19 |
| CY1122208T1 (el) | 2020-11-25 |
| US10525051B2 (en) | 2020-01-07 |
| HRP20192120T1 (hr) | 2020-02-21 |
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