KR20110004425A - 말초적 작용 오피오이드 길항제의 경구 투여 - Google Patents
말초적 작용 오피오이드 길항제의 경구 투여 Download PDFInfo
- Publication number
- KR20110004425A KR20110004425A KR1020107024868A KR20107024868A KR20110004425A KR 20110004425 A KR20110004425 A KR 20110004425A KR 1020107024868 A KR1020107024868 A KR 1020107024868A KR 20107024868 A KR20107024868 A KR 20107024868A KR 20110004425 A KR20110004425 A KR 20110004425A
- Authority
- KR
- South Korea
- Prior art keywords
- opioid
- therapeutically effective
- opioid antagonist
- hours
- peripherally acting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- 238000000034 method Methods 0.000 claims description 38
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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|---|---|---|---|
| US12686808P | 2008-05-07 | 2008-05-07 | |
| US61/126,868 | 2008-05-07 |
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| KR20110004425A true KR20110004425A (ko) | 2011-01-13 |
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| EP (1) | EP2300009A1 (https=) |
| JP (1) | JP2011519930A (https=) |
| KR (1) | KR20110004425A (https=) |
| CN (1) | CN102014907A (https=) |
| AU (1) | AU2009244805B2 (https=) |
| BR (1) | BRPI0912219A2 (https=) |
| CA (1) | CA2723685C (https=) |
| EA (1) | EA201001643A1 (https=) |
| IL (1) | IL208794A0 (https=) |
| MX (1) | MX2010011727A (https=) |
| MY (1) | MY156913A (https=) |
| NZ (1) | NZ589733A (https=) |
| WO (1) | WO2009137086A1 (https=) |
| ZA (1) | ZA201007531B (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| HRP20150037T4 (hr) | 2003-04-08 | 2022-09-02 | Progenics Pharmaceuticals, Inc. | Farmaceutske formulacije koje sadrže metilnaltrekson |
| TWI489984B (zh) | 2006-08-04 | 2015-07-01 | Wyeth Corp | 用於非經腸道傳輸化合物之配方及其用途 |
| UA123856C2 (uk) * | 2010-03-11 | 2021-06-16 | Уайт Елелсі | Фармацевтичні композиції метилналтрексону та натрію додецилсульфату для перорального введення |
| AU2011307608B8 (en) * | 2010-09-30 | 2015-08-27 | Grünenthal GmbH | Crystalline naloxol-PEG conjugate |
| KR20140107540A (ko) * | 2011-12-19 | 2014-09-04 | 샐릭스 파마슈티컬스 리미티드 | 메틸날트렉손의 경구 조성물을 사용하는 오피오이드 유발성 변비의 치료 및 예방 방법 |
| CA3042642A1 (en) | 2013-08-12 | 2015-02-19 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
| CN104546791A (zh) * | 2013-10-16 | 2015-04-29 | 辽宁亿灵科创生物医药科技有限公司 | 一种阿片受体拮抗剂的固体制剂及其制备方法 |
| US10172797B2 (en) | 2013-12-17 | 2019-01-08 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| LT3137081T (lt) | 2014-04-28 | 2018-02-26 | Orphomed, Inc. | Buprenorfino dimeras ir jo naudojimas gydant virškinamojo trakto sutrikimus |
| CA2955229C (en) | 2014-07-17 | 2020-03-10 | Pharmaceutical Manufacturing Research Services, Inc. | Immediate release abuse deterrent liquid fill dosage form |
| WO2016064873A1 (en) | 2014-10-20 | 2016-04-28 | Pharmaceutical Manufacturing Research Services, Inc. | Extended release abuse deterrent liquid fill dosage form |
| WO2017092638A1 (zh) * | 2015-12-01 | 2017-06-08 | 江苏恒瑞医药股份有限公司 | 阿片样受体拮抗剂类衍生物、其制备方法及其在医药上的应用 |
| CN107033154B (zh) * | 2016-02-02 | 2020-02-04 | 上海瀚迈生物医药科技有限公司 | 阿片受体拮抗剂缀合物及其应用 |
| CN109134479A (zh) * | 2017-06-27 | 2019-01-04 | 石家庄蒎格医药科技有限公司 | 结晶聚乙二醇纳洛酮草酸盐及制备方法 |
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| US6451806B2 (en) * | 1999-09-29 | 2002-09-17 | Adolor Corporation | Methods and compositions involving opioids and antagonists thereof |
| AU776567B2 (en) * | 1999-11-01 | 2004-09-16 | Evans, Brian K | Composition for treatment of constipation and irritable bowel syndrome |
| ES2654819T3 (es) * | 2001-10-18 | 2018-02-15 | Nektar Therapeutics | Conjugados poliméricos de antagonistas de opioides |
| US20060182692A1 (en) * | 2003-12-16 | 2006-08-17 | Fishburn C S | Chemically modified small molecules |
| EP2905033B1 (en) * | 2003-12-16 | 2020-09-02 | Nektar Therapeutics | Monodisperse PEGylated naloxol compositions |
| KR101421747B1 (ko) * | 2006-04-21 | 2014-07-30 | 넥타르 테라퓨틱스 | 모르피논의 입체선택적 환원 |
| JP2010509227A (ja) * | 2006-11-07 | 2010-03-25 | ネクター セラピューティックス エイエル，コーポレイション | オピオイド作動薬およびオピオイド拮抗薬の用量形態および同時投与 |
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2009
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2010
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2723685A1 (en) | 2009-11-12 |
| MY156913A (en) | 2016-04-15 |
| EP2300009A1 (en) | 2011-03-30 |
| BRPI0912219A2 (pt) | 2015-10-06 |
| MX2010011727A (es) | 2010-11-30 |
| EA201001643A1 (ru) | 2011-06-30 |
| AU2009244805A1 (en) | 2009-11-12 |
| ZA201007531B (en) | 2012-03-28 |
| AU2009244805B2 (en) | 2013-01-10 |
| IL208794A0 (en) | 2010-12-30 |
| WO2009137086A1 (en) | 2009-11-12 |
| US20110160239A1 (en) | 2011-06-30 |
| NZ589733A (en) | 2012-07-27 |
| CA2723685C (en) | 2016-09-27 |
| CN102014907A (zh) | 2011-04-13 |
| JP2011519930A (ja) | 2011-07-14 |
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