KR20100094223A - The drinking water composition for dissolution of hangover - Google Patents

Abstract

PURPOSE: A drinking composition for reducing hangover is provided to protect the liver function of a user, and to secure the effect on helping the recovery from the hangover. CONSTITUTION: A drinking composition for reducing hangover contains 90~98.9wt% of clustered water, 0.1~9wt% of niacinamide, 0.5~9.4wt% of cinnamon extract, 0.5~9.4wt% of forsythia saxatilis extract, 5wt% of stevia, 1wt% of piperine, 1wt% of oldenlandia diffusa extract, and 1wt% of taraxacum platycarpum extract.

Description

Drinking water composition for hangovers {The drinking water composition for dissolution of hangover}

The present invention relates to a beverage composition for resolving hangover, more specifically, 90 to 98.9 wt% of clustered water, 0.1 to 9 wt% of niacinamide, 0.5 to 9.4 wt% of cinnamon extract, and 0.5 to pontoon extract It is composed of 9.4% by weight is harmless to the human body and has an excellent hangover effect and protects the liver function, and relates to a drink composition for hangover resolution to obtain a beverage having excellent fatigue recovery effect.

Modern people are subject to a lot of stress in their daily lives, not only do they drink as a way to relieve accumulated stress, but also increase their drinking opportunities due to drinking and entertainment.

However, the side effects of heavy drinking may be a hangover, such as heavy, painful or sore throat. This hangover is caused by the poisoning effect of ethanol or acetaldehyde accumulated in hepatocytes, and if these substances accumulate in the liver cells for a long time and cause poisoning, symptoms such as fatigue, abdominal bloating and vomiting may occur. Will be raised.

Alcohol is mainly absorbed in the digestive organs. Alcohol absorbed into the body is excreted in the urine and sweat through the respiration 10% and the rest is broken down in the liver.

In normal ethyl alcohol metabolism, ethyl alcohol is absorbed from the stomach or small intestine and enters the blood vessels and is transferred to the liver. Hepatocytes contain alcohol dehydrogenase (ADH), which oxidizes alcohol to acetaldehyde, and the acetaldehyde is decomposed into acetic acid by acetaldehyde dehydrogenase in hepatocytes and transferred to muscle or adipose tissue throughout the body. Finally, it is decomposed into carbon dioxide gas and water. In addition, the acetaldehyde dehydrogenase has a type II which initiates oxidation even at low concentrations of acetaldehyde and a type I which does not function unless acetaldehyde does not have a high concentration, but oriental people generally lack or lack type II acetaldehyde enzyme. Therefore, the oxidation of acetaldehyde is slow, and thus normal metabolism is disturbed by the poisoning of acetaldehyde and / or ethyl alcohol which is not oxidized, so that various hangovers are felt. In order to alleviate the hangover after drinking alcohol, a large number of drinks prepared by mixing single or mixed herbal preparations or artificial preparations have been developed.

Various types of medicines have been developed that contain ginseng and thorny ginseng as the main ingredients, which are known to be useful in relieving hangover as herbal medicine or folk remedies. Among them, many nourishment tonic drinks are commercially available. Various ingredients such as honey and vitamins are also marketed as nourishing tonic by formulating in an appropriate amount. However, although herbal medicines such as ginseng, thorny ginseng, Ocimum sanctum Linn and Tinosporamalabarica, and biomaterials such as melatonin have been reported to exhibit hangover, some of the various changes caused by drinking are reported. It appears to be effective only on the items or insignificant, and can not find a big characteristic technique simply by using the herbal extract that has been used as a herbal medicine in the Orient, usually to use nourishment tonic or known efficacy simply It is only for the purpose.

In addition, there have been active studies of preparations that can reduce the hangover and decrease the blood alcohol level, but no preparations have shown outstanding results. In the past, products that simply formulated coarse plant extract fermentation products have been introduced, but preparations using only existing plant extract fermentation broth often produce sediments when left for a long time, and are very difficult to take due to their unusual smell. In particular, in the case of preparing beverages by adding vitamins, minerals, amino acids, etc. to these plant extract fermentation broths, the effectiveness and stability of the products according to changes over time and the stability of products resulting from sterilization of various bacteria Problems are caused, and problems such as insoluble precipitates being produced and taste or color discoloration usually occur, so that the formulation was not successful.

Recently, products containing plant extracts containing soybean sprouts as main ingredients or products containing embryonic and soybean extracts have been introduced, but they are also pointed out that many problems still need to be solved in terms of stability of the preparation. As such, various herbal medicines have been used to remove hangovers after drinking, and recently, various drink preparations including herbal medicines for removing hangovers are commercially available. These drinks are used alone or after drinking alcoholic beverages with high alcohol content. In addition to drinking it.

However, a drink containing some herbal medicines may not only cause systemic boredom, bloating, vomiting or abdominal pain, but also some drink may be sold at high prices by using expensive herbal medicines.

For example, Korean Patent No. 178696 describes a medicinal composition for liver protection and treatment of liver disease, and Patent Publication No. 2001-0050333 discloses a beverage and a method for producing the herbal medicine for relieving hangover and improving liver function. , Patent No. 345798 discloses a hangover-relieving functional food using the earth tree, alder tree, 칡 mixture and its manufacturing method, and Patent Publication No. 2002-0021980 discloses "an alcohol metabolism enhancer and liver disorder reducing agent", Patent No. 2002-0004193 discloses "composition for removing hangover and soy sauce containing alcohol absorption inhibitor", and Patent No. 2003-0005127 discloses "health food based on earth and alder".

In addition, Patent No. 403720 discloses "lower alcohol insoluble extract fractions and polysaccharide substances having hepatotoxicity, hangover and fatigue-relieving activity isolated from larvae sprigs and compositions containing them", and Patent No. 403721 "isolating from larvae. Lower alcohol insoluble extract fractions and polysaccharide materials and compositions containing the same, which have been subjected to hepatotoxic and hangover-relieving activity, are described in Patent No. 403722, "Low alcohol insoluble extracts having hepatoprotective activity isolated from lumber wood, Polysaccharides and compositions containing the same are disclosed in Korean Patent Publication No. 2004-0052930, "Hangover releasing agent and hangover releasing agent containing the same as an active ingredient" and the like, but satisfactory hangover effect was not obtained.

Accordingly, an object of the present invention is to provide a hangover solution for the hangover that is harmless to the human body, has an excellent hangover effect and protects the liver function as well as excellent fatigue recovery effect.

In order to achieve the above objects as well as other objects that can be easily expressed, the present invention provides 90-98.9 wt% of clustered water, 0.1-9 wt% of niacinamide, 0.5-9.4 wt% of cinnamon extract, and duct bridge. By preparing and drinking a hangover drink composed of 0.5 ~ 9.4% by weight of the extract, there is no harm to the human body, it is excellent in the hangover relieving effect and protects the liver function, and the fatigue recovery effect can be obtained.

Drinking water composition for hangover relief according to the present invention is harmless to the human body is excellent hangover relief effect and can protect the liver function as well as obtain a fatigue recovery effect.

Hangover beverage composition according to the present invention is composed of 90 to 98.9% by weight of clustered water, 0.1 to 9% by weight of niacinamide, 0.5 to 9.4% by weight of cinnamon extract and 0.5 to 9.4% by weight duct extract Characterized.

Normally, water is composed of 35 water molecules connected to form a very large cluster, and when sulfur dioxide, carbon dioxide, carbon monoxide, and chlorine gas are dissolved in water, they are entangled between clusters of water molecules. These gases are dissolved in water to make sulfuric acid, sulfurous acid, carbonic acid, hydrochloric acid, and acidify the water, and toxic heavy metals such as mercury, lead, cadmium, and aluminum are also entangled in the cluster. The large water clusters containing gas streams and toxic metals that acidify the water are not effective because they not only have harmful effects on the human body but also prevent hangover resolution.

Therefore, in the present invention, the clusters of water molecules are subdivided into 5-6 molecules through far-infrared radiation, magnetization, ultrasonication, etc. in the range of 4-14 μm to blow toxic gases entangled between the clusters of water molecules into the air. Heavy metals are precipitated using clustered water with supernatant only.

The clustered water can be prepared by various known methods, and it is preferable to use those stabilized by known stabilization methods.

It is effective to use 90 to 98.9% by weight of the total composition of the clustered water, and when the amount of the clustered water is used to less than 90% by weight, the amount of the other components increases, and the hangover due to the increase of the amount of other components is increased. The effect of improving the resolution is not economical, and when used in excess of 98.9% by weight, the content of niacinamide, cinnamon extract or ductile extract is lowered there is a problem that the effect to be obtained in the present invention is not satisfactory.

Niacinamide is an amide compound of niacin, a vitamin B ₃ .

(니아신)

(Niacin)

(니아신아마이드)

(Niacinamide)

Vitamin B ₃ is derived from pyridine trihydrate, which has an anti-Pelagra effect. Niacinamide is a water-soluble vitamin that is heat sensitive and is temporarily stored in liver, brain and heart tissues.

In addition, niacin acts as a coenzyme in the enzyme reactions involved in carbohydrates, fats and protein metabolism, so it is an important vitamin that is used to make sure that all the foods we eat are used properly, and it also works to dilate blood vessels. In particular, the peripheral blood vessels to expand the action is necessary to nourish the heart or brain.

Most of animal tissues exist in the form of niacinamide, but the free form in animals is very small, and most of them are co-enzymes of niacinamide adenine dinucleotide (NAD) or niacinamide adenine dinucleotide phosphate (NADP).

In physiological action, it acts as a coenzyme of various dehydrogenases to receive hydrogen or electrons from the substrate, and oxidizes the substrate by reducing niacinamide, NAD or NADH.

It also acts as an important coenzyme for carbohydrate, fatty acid and amino acid metabolism, maintains proper body growth and energy supply, promotes the synthesis of bile acids necessary for the absorption of fats and fat-soluble nutrients (vitamins A, D, E and K) Regulates the synthesis of (thyroxine, insulin, somatropin, STH), activates in liver, skin, intestine, bone marrow, promotes fat metabolism, and inhibits synthesis of cholesterol and triglycerides.

Niacin is a plant, grain product, coffee, lean meat, fish, beef liver, soy, beef, chicken, lamb, lamb, veal, pea, fresh, radish, clam, pork salt, pork kidney, oyster, halibut, Unlike bream, greens, and other vitamins that must be absorbed from the outside, some of the required amount is synthesized in the liver from an essential amino acid called tryptophan.

Niacinamide used in the present invention serves to resolve the hangover by decomposing acetaldehyde with acetic acid. That is, as described in the following formula, niacinamide is decomposed to acetic acid through a reaction of dehydrogenation by separating hydrogen from acetaldehyde.

In the present invention, it is effective to use niacinamide in an amount of 0.1 to 9% by weight based on the total composition, and when niacinamide is used in less than 0.1% by weight, the hangover relieving effect is weak, and when used in excess of 9% by weight, niacinamide is added. The synergistic effect is not economical and can cause side effects from overdose.

Cinnamon is a bark of Cinnamomum cassia Blume or Cinnamomum zeylanicum Blume, or a similar bark of the same plant, which promotes blood circulation, eliminates coldness in the chest, promotes appetite and promotes digestion. It can be used for limb paralysis, etc., to suppress gastrointestinal spasms, to promote gastrointestinal tract movements, to release gas and improve absorption, and to prevent the fermentation of abnormal intestines. Pharmacological action has been reported to improve the bacteriostatic action, white bacteriophage suppression effect, pruning effect, saliva and gastric juice secretion action.

In the present invention, cinnamon acts to rapidly absorb niacinamide into hepatocytes by acting on the cell membrane of hepatocytes, and it is effective to use 0.5 to 9.4 wt% based on the total composition, and the amount of cinnamon used is less than 0.5 wt%. In this case, there is a disadvantage in that the addition effect is weak and the hangover is not quickly resolved. When the amount exceeds 9.4% by weight, the synergistic effect is not so low that it is not economical and raises the blood pressure.

Yeon-kyo is a forsythia fruit with a peculiar smell and a bitter taste. Yeonkyo lowers and detoxifies the fever so that the heat of the heart at the beginning of the fever, high fever and mental dreams, boils, rashes, appendicitis, lung abscess, lymphadenitis, sore throat, diuretic, anti-inflammatory effect.

Antimicrobial, anti-inflammatory, hypotensive, hemostatic, hepatic, antipyretic, anti-diuretic, diuretic effects were reported as pharmacological action. The appearance is oval or long oval-shaped debris with pointed ends and fruit stems at the base. There is also. The outer surface is light brown or dark brown with scattered light gray small ridges and two longitudinal grooves. The well-done splits along the longitudinal groove and the end is twisted. The inside of the split rind is yellowish brown with a septum in the middle. Seeds have elongated oval wings.

In the present invention, when the soft drink is a drink to drink the niacin amide contained in the drink to play a role to move quickly to the liver cells, it is effective to use 0.5 to 9.4% by weight based on the total composition, the amount of the soft drink is 0.5 If it is less than the weight percent of the addition effect is weak because there is a disadvantage that the hangover is not made quickly, if it exceeds 9.4% by weight the addition synergistic effect is not so weak economical.

In the present invention, the cinnamon and the duct extract are extracted with water, a lower alcohol having 1 to 4 carbon atoms or a mixed solvent thereof, most preferably by adding ethanol.

In addition, the cinnamon and smoked extract according to the present invention can be prepared as follows.

Wash cinnamon or ducts thoroughly with water and dry them in the shade. Dried cinnamon or ducts are placed in an extraction container, an appropriate amount of extraction solvent is added and extracted for a certain time at an appropriate temperature. The extract can be filtered and concentrated using a vacuum rotary evaporator or the like.

The amount of the extraction solvent is 2 to 10 times the dry weight of the herbal medicine, the extraction temperature is 30 to 90 ℃, more preferably 60 to 80 ℃, most preferably maintained at about 60 ℃ decay, discoloration and odor Most effective in the prevention of

In addition, the extraction time is carried out for 5 to 20 hours, preferably for 10 hours.

After obtaining the cinnamon or smoked extract, the solids may be removed using a filter paper, the suspension may be centrifuged, and the supernatant may be filtered under reduced pressure.

The filtered extract can be concentrated under reduced pressure at 20 ~ 100 ℃, preferably 50 ~ 70 ℃ with a vacuum rotary concentrator.

When preparing a drink using the drink composition for removing the hangover configured as described above, there is a fear that gourds may occur from the herbal ingredients, but in the present invention, stevia was used to correct the sugar.

Stevia is a plant boomed with low-calorie natural sweeteners introduced in our country in the 1970's. In the country of origin Paraguay, the native people called "Khaihae" since ancient times, it was used as tea sweetener in the Indian word meaning sweet grass. .

When you open the taste of stevia leaves, you can see that it has a sweet taste like sugar, and it is used as a sweetener in coffee or tea. Stevia leaves contain stevioside, which is 200 times sweeter than sucrose, and stevioside, extracted from leaves, is colorless and odorless. It is low in 4 calories of 1g of rape and is used as a sweetener for diabetics. Is effective.

In addition, it is well soluble in water and alcohol, heat-resistant and non-toxic, so it is used as a sweetener for ice cream, sherbet, chewing gum, soft drinks, medicines and diet foods.

Stevia is an effective sweetener at the time when the development of hypoglycemic agents such as diabetes, heart disease, obesity, and tooth decay, which is called the culture disease of modern people, is now commercialized as powders, tablets, tea bags, and the like.

In the present invention, it is used to provide not only sugar correction but also blood circulation improving effect and antioxidant effect, and may be appropriately adjusted according to the preference of the beverage to be prepared. Preferably it is effective to use less than 5% by weight of the composition consisting of clustered water, niacinamide, cinnamon extract and soft duct extract.

On the other hand, in the present invention, a substance having a known hangover-relieving effect, a substance which helps to quickly transport niacinamide to hepatocytes, in particular, piperine, white chlorosis extract, and dandelion extract extracted from pepper may be added.

Pepper, the fruit of piper nigrum, an Indian native shrub, is still the most commonly used spice, and its active ingredient is piperine, whose chemical formula is C ₁₇ H ₁₉ O ₃ N. The structural formula is as follows. The spicy taste we feel when we consume piperine is not actually a taste, but our painful nerve reaction to the chemical action that piperine produces. When a piperine molecule binds to a protein molecule at the nerve ending, the protein at the nerve ending emits a signal. This signal travels along the nerves to the brain, making it pungent.

Piperin extracted from the pepper in the present invention has a function such as duct bridge to assist in the rapid transport of niacinamide to hepatocytes, can be used as an additive for improving liver function, and is used in small amounts. Preferably it is effective to use less than 1% by weight of the composition consisting of clustered water, niacinamide, cinnamon extract and soft duct extract.

In addition, Baekhwasaengcho is a perennial herb of the dicotyledon plant Maddera Maddera, with a slight smell, bitter taste, and cold nature. It is used for seawater, tonsillitis, and sore throat due to waste heat, and is also used for appendicitis, pelvic inflammatory disease, jaundice hepatitis and dysentery.

In addition, Bacteria is effective against all cancers and tumors, removes waste products from the blood, removes inflammatory substances, clears blood, facilitates blood circulation, enhances human immune system, and promotes urine excretion. It excretes tissue waste and relieves edema.

In the present invention, Baekhwasaengcho is prepared in the form of extract using the same method as the method of obtaining cinnamon or poncho extract as well as the role of helping to relieve hangover, the function of helping the rapid absorption of niacinamide clustered water, niacin It is effective to use less than 1% by weight of the composition consisting of amide, cinnamon extract and duct extract.

Dandelion is a perennial herb of the dicotyledonous plant Lantern Asteraceae, and Pogongyoung, a plant before flowering, is known to be effective for heat swelling, mastitis, sore throat, appendicitis, peritonitis, acute hepatitis, and jaundice. Because it contains excellent effect of improving liver function, it can be useful for hepatitis, cirrhosis, cholelithiasis, jaundice.

Dandelion in the present invention is manufactured in the form of an extract using the same method as the method of obtaining cinnamon or yeonja extract not only helps to relieve hangover, but also functions to improve liver function clustered water, niacinamide, cinnamon extract And it is effective to use less than 1% by weight of the composition consisting of soft duct extract.

The following examples illustrate the invention in more detail, but do not limit the scope of the invention.

Example 1

 191cc of clustered water, 1g of niacinamide, finely divided the cluster of water molecules into 5-6 molecules through far-infrared radiation in the range of 5-10㎛, and then dried cinnamon or duct into a extraction container, 4 g of cinnamon and duct extract and 10 g of stevia, which were prepared by adding water and heating, extracting hot water for 2 hours, removing solids using a filter paper, centrifuging the suspension, and filtering the supernatant under reduced pressure, were mixed homogeneously. After stirring until, ultraviolet sterilization and packaging to prepare a hangover solution of the present invention.

Experimental Example 1

The stability and alcohol degradation efficacy of the beverages prepared in Example 1 were tested.

Acute toxicity test was performed using 6-week-old SPF SD rats. Two animals per group in the hangover relief composition of the present invention niacinamide, cinnamon extract, soft-leaved extract each and the prepared beverages were suspended in 0.5% methylcellulose solution at a ratio of 1: 1, twice at a dose of 15 ml / kg. Oral administration.

After administration of the test substance, the animals were examined for mortality, clinical symptoms, and weight changes. Hematological and blood biochemical tests were performed. After autopsy, the abdominal and thoracic organ abnormalities were observed. No significant clinical symptoms or deaths were noted in any of the animals, and no toxic changes were observed in weight changes, blood tests, blood biochemical tests, autopsy findings, etc.

In addition, as a result of comparing the microscopic findings of the experimental group and the control group not administered the hangover drink of the present invention, in the real organs such as liver, spleen, kidney, brain, skin, reproductive system, gastrointestinal, colon, heart, lung, etc. It has been confirmed that the hangover composition of the present invention does not exhibit toxicity.

As can be seen from the above results, all the drinking water composition for hangover resolution according to the present invention was determined to be a safe substance that does not show a toxicity change in rats up to 25 ml / kg.

On the other hand, 6 mice 6 weeks old (BALB / c, Biotechnology Research Institute, Laboratory Animal Center) were selected for 5 treatment groups and provided with only drinking water and fasted for 24 hours, followed by 40% ethanol in stainless steel sonde (length, 10 cm ) By forced oral administration. 10 ml / kg of 40% ethanol was orally administered per mouse, and at 1 hour, only 10 ml / kg of water was administered to the control group, and 10 ml / kg of drinking water for hangover prepared in Example 1 was orally administered to the experimental group. Four hours after oral administration, blood was drawn from the heart and an alcohol concentration kit (Sigma, USA, 337A) was used to measure blood alcohol concentration.

As a result of the experiment, when the blood alcohol concentration of the control group not administered the hangover drinker was converted to 100%, the blood alcohol concentration of the experimental group to which the hangover drinker of Example 1 was administered was reduced to 50% or less. . Therefore, it was confirmed that the composition for hangover elimination of the present invention has excellent alcohol resolving power and has an excellent hangover elimination effect.

In addition, as a result of measuring the acetaldehyde concentration in the liver at 4 hours after oral administration, when the acetaldehyde concentration in the liver of the control group which did not receive the hangover drink was converted to 100%, the hangover of Example 1 It was found that the acetaldehyde concentration of the experimental group to which the drinking water was administered decreased to 25% or less.

Claims (5)

90 to 98.9 wt% of clustered water, 0.1 to 9 wt% of niacinamide, 0.5 to 9.4 wt% of cinnamon extract, and 0.5 to 9.4 wt% of duct extract. The method of claim 1, wherein stevia is added to the total weight of the composition to 5% by weight or less characterized in that the hangover solution. The method according to claim 1 or 2, characterized in that the addition of 1% by weight or more pipelin separated from the pepper relative to the total weight of the composition hangover solution. The method according to claim 1 or 2, Hangover saengcho extract based on the total weight of the composition, characterized in that the addition of less than 1% by weight, hangover solution for drinking hangover. The method of claim 1 or 2, wherein the dandelion extract is added to the total weight of the composition to 1% by weight or less characterized in that the hangover solution.