KR20100034528A - A herb medicine gelly and method for preparing the same - Google Patents

A herb medicine gelly and method for preparing the same Download PDF

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KR20100034528A
KR20100034528A KR1020080093720A KR20080093720A KR20100034528A KR 20100034528 A KR20100034528 A KR 20100034528A KR 1020080093720 A KR1020080093720 A KR 1020080093720A KR 20080093720 A KR20080093720 A KR 20080093720A KR 20100034528 A KR20100034528 A KR 20100034528A
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유병혁
조용택
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재단법인 대구테크노파크
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/254Acanthopanax or Eleutherococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

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Abstract

PURPOSE: A medicinal herb jelly using gelling component, sweetener, and natural antibacterial is provided to treat arthritis and effectively administer medicinal herb component. CONSTITUTION: A medicinal herb jelly contains mixture concentrate liquid of Panax notoginseng, Rehmanniae Radix Preparata and Eleutherococcus senticosus as active ingredient. A method for manufacturing the medicinal herb jelly comprises: a step of pulverizing the Panax notoginseng, Rehmanniae Radix Preparata and Eleutherococcus senticosus and mixing at a ratio of 5:4:1; a step of adding purified water, extracting with hot water, and filtering to obtain 50Brix of medicinal herb mixture concentrate liquid; a step of mixing with 65-70 weight% of kappa-carrageenan, 3.5-4.0 weight% of glucomannan, 11.0-11.5 weight% of LB.G, and 15-20 weight% of iota-carrageenan; a step of adding purified water and stirring by 90°C to obtain gelling solution; a step of mixing with 28-33 weight% of gelling agent, 60-65 weight% of medicinal herb mixture concentrate liquid, 1.5-2.0 weight% of sodium citrate, 4.0-4.5 weight% of potassium chloride, 0.5-1.0 weight% of steviten fresh, and 0.5-0.6 weight% of grapefruit seed extract; and a step of sterilizing and cooling the mixture.

Description

한방소재를 이용한 생약젤리 및 그 제조방법{A herb medicine gelly and method for preparing the same}Herbal medicine jelly using herbal materials and its manufacturing method {A herb medicine gelly and method for preparing the same}

본 발명은 한방소재를 이용한 생약젤리 및 그 제조방법에 관한 것으로, 보다 구체적으로는 생약 성분인 삼칠, 숙지황 및 가시오가피를 주성분으로 하고, 겔화 성분, 감미제, 천연 항균제 등을 혼합하여 겔화시켜 젤리형태로 제조된 복용이 편리하고 휴대가 간편한 한방소재 생약젤리 및 그 제조방법에 관한 것이다.The present invention relates to a herbal medicine jelly using a herbal material and a method for manufacturing the same, more specifically, the main ingredients of Samchil, Sukji sulfur and thorny opipi as a main ingredient, and gelling by mixing gelling ingredients, sweeteners, natural antibacterial agents, etc. It relates to a convenient herbal medicine prepared herbal medicine jelly and a method of manufacturing the same.

종래부터 한약은 약재를 달인 물로 색은 거무스름하고 맛은 쓰고 독특한 냄새가 나는 탕약’형태로 복용하는 것이 일반적이었으며, 약재적 특성으로 인하여 맛이 쓰고 먹기에 다소 힘들다는 단점이 있었다. 하지만 근래들어 현대인의 라이프 스타일에 맞춰 복용이 편리하고 휴대가 간편한 한약이 선보이고 있다.Traditionally, herbal medicines were used as a decoction of decoctions with sweetened water with a blackish color, taste, and a unique smell. However, recently, herbal medicines that are convenient to take and carry are being introduced according to the lifestyle of modern people.

예로써 기존 탕약의 약효와 성분을 그대로 유지하면서 먹기 좋게 초콜릿 향과 바닐라 향을 첨가한 ‘향기탕약’이 대표적이다. 최근에는 아이들의 장(腸) 건강을 위해 건강기능식품에 쓰이는 ‘올리고당’으로 약하게 단맛을 낸 한약도 나온 바 있다. 또한 색동한약은 약재를 증류한 맑은 탕약에 천연 약재에서 추출한 빨강, 주황, 노랑, 초록 등의 빛깔을 입힌 것. 오미자로 붉은색, 진피로 노랑색, 치자로 주황색을 내서 주스처럼 마실 수 있게 제조되고 있으며, 또한, 이미 만든 탕약을 농축해 젤리나 사탕을 만들기도 한다. 한약을 농축한 뒤 가루로 만든 과립제는 소화 흡수율이 좋고 오래 보관할 수 있는 장점이 있다. 짜먹는 한약은 요구르트 형태의 젤 타입으로 포장에서부터 약이라는 느낌이 들지 않는다. 입 안에 짜 넣으면 한약 성분이 든 알갱이가 입안에서 녹지 않고 식도를 넘어가면서 녹는다. 그밖에도, 한약을 액제, 정제, 환제, 과립제, 캡슐제, 주사제, 패치 등의 형태로 위생과 안전을 겸비한 한약이 선보이고 있다. For example, 'Fragrance Tang', which adds chocolate and vanilla flavors, is a good example. Recently, there has been a Chinese medicine that has been weakly sweetened with “oligosaccharides,” which are used in dietary supplements, for the intestinal health of children. In addition, Saekdong Herbal Medicine is a clear, distilled herbal medicine with red, orange, yellow, and green color extracted from natural medicines. It is made from Schisandra chinensis red, dermis yellow, and gardenia orange to drink like juice, and it also concentrates the already made decoction to make jelly or candy. Granules made of powder after concentrating Chinese medicine have the advantage of good digestion absorption and long storage. The salty Chinese medicine is a yoghurt gel type that doesn't feel like a medicine from the packaging. When squeezed into the mouth, the grains containing the herbal ingredients do not melt in the mouth, but melt over the esophagus. In addition, herbal medicines that combine hygiene and safety in the form of liquids, tablets, pills, granules, capsules, injections, patches, etc. are being introduced.

이들 중 한약을 젤리 형태로 제조하기 위한 기술로서 대한민국 특허출원 제10-1991-0014110호 "한약의 약리성분과 종합 아미노산의 영양을 복합적으로 겸비한 한방 젤라틴 생성물 및 이의 제조방법"에는 한약 생약으로부터 유효 성분을 추출하고 냉각한 후,순수한 동물성 단백질과 트립토판 및 메티오닌의 양 아미노산을 함께 첨가해서 균질하게 용해시킨 다음 냉각처리하여 묵과 같이 단단한 젤리상의 탄성체로 만드는 기술이 개시되어 있고, 대한민국 등록특허 제10-0448009호 "생약추출물 함유 기능성 젤리의 제조 방법 및 그에 의해 제조된 기능성 젤리"에는 한방생약으로부터 추출한 생약추출물 50 내지 80중량%에 올리고당 5 내지 30중량%, 젤화제 0.2 내지 5중량%, 유기산 0.1 내지 5중량%, 유기산염 0.1 내지 5중량% 및 식이섬유 0.1 내지 1중량%를 혼합함으로써 여러가지 기능성을 갖는 생약추출물 함유 기능성 젤리를 제조하는 방법이 개시되어 있다. As a technique for manufacturing a Chinese medicine in the form of jelly, Korean Patent Application No. 10-1991-0014110 "Herbal gelatin product combining the pharmacological component of the Chinese medicine and the nutrition of a comprehensive amino acid and a method for preparing the same" includes the active ingredients from Chinese herbal medicines After extracting and cooling, a pure animal protein, both amino acids of tryptophan and methionine are added together to dissolve homogeneously, and then cooled to make a hard jelly like elastomer as a jelly, and is disclosed in Korean Patent No. 10-0448009 No. "Method for preparing herbal extract-containing functional jelly and functional jelly prepared by the same" includes 50 to 80% by weight of herbal extract extracted from herbal medicines, 5 to 30% by weight oligosaccharide, 0.2 to 5% by weight gelling agent, and 0.1 to 5 organic acid. By mixing by weight, 0.1 to 5% by weight of organic acid salt and 0.1 to 1% by weight of dietary fiber A method for preparing a herbal extract-containing functional jelly having various functionalities is disclosed.

이 밖에 생약제품을 젤리 형태로 제조하는 다양한 기술이 공지되어 있다.In addition, a variety of techniques for preparing herbal products in the form of jelly are known.

한편, 관절염 관련 질환은 전세계 인구의 약 12% 이상이 고통을 겪고 있는 대표적인 퇴행성, 난치성 질환이다. 관절염은 크게 퇴행성 관절염, 류마티스 관절염, 관절외 류마티즘 또는 콜라겐 질환으로 크게 나누어 지며, 퇴행성 관절염이 주를 이룬다. Arthritis-related diseases, on the other hand, are representative degenerative and refractory diseases in which about 12% of the world's population suffers. Arthritis is largely divided into degenerative arthritis, rheumatoid arthritis, extra-articular rheumatoid or collagen disease, and degenerative arthritis is mainly.

현재까지 관절염의 정확한 병인은 확인이 되지 않고 있으나 관절염의 증상을 개선하는 약물요법과 수술들이 시행되고 있다. 하지만, 부작용이 발견되는 경우가 있으며 이에 새로운 작용점의 물질 탐색과 예방제가 필요하다. To date, the exact etiology of arthritis has not been identified, but drug therapies and surgeries to improve the symptoms of arthritis have been performed. However, there are cases where side effects are found, which necessitates the exploration and prevention of substances at new working points.

삼칠, 숙지황, 가시오가피는 각각 항염증과 연골 및 뼈 파괴 억제 효능이 우수한 물질로서 이미 동양권에서 2000년 이상 사용되어져 온 전통의 소재이며 그 안전성 또한 널리 알려져 있다. Samchil, Sukjihwang and Prickly Ophipi are excellent anti-inflammatory, cartilage and bone destruction inhibitors, and have been used for more than 2000 years in the East.

삼칠(Panax notoginseng)은 두릅나무과에 속하는 다년생 초본으로 가을에 채취하여 뿌리를 사용하는 약재로 우리나라를 비롯한 동양에서 심혈관 질환, 염증, 지혈 등의 목적으로 사용되어 왔으며 최근에는 ginsenoside와 notoginsenoside 같은 dammarane계 사포닌이 생리 활성을 나타내는 것으로 밝혀졌다. 우수한 소염, 진통 및 지혈작용이 있어 간염을 비롯한 많은 염증질환에 유효할 뿐 아니라 외상, 절상으로 생긴 출혈과 내출혈에 유효한 것으로 보고되어져 있다. Samchil ( Panax notoginseng ) is a perennial herb belonging to the family arboraceae , which is harvested in the fall and uses roots. It has been used in Korea and other countries for cardiovascular disease, inflammation, and hemostasis. Recently, dammarane saponins such as ginsenoside and notoginsenoside have been used. It was found to exhibit physiological activity. It has been reported to be effective for many inflammatory diseases including hepatitis as well as for anti-inflammatory, analgesic and hemostatic actions, as well as for bleeding and internal bleeding caused by trauma and cuts.

숙지황(Rehmanniae Radix Preparata)은 현삼과에 속하는 지황(Rehmannia glutinosa)의 뿌리를 황주(黃酒)에 적신 후 쪄서 말린 것으로 한방에서 약재로 사용되고 있으며, 허리와 무릎이 시리고 아픈 증상이나 월경이상, 어지럼증 등을 치 료하고 각종 만성병 중 몸이 허약하여 나타나는 내열, 인후건조(咽喉燥), 갈증 등의 증상에 쓰여져 왔다. 또한 지황은 약제의 가공방법에 따라 생지황, 건지황 및 숙지황으로 분류된다. 주요성분으로는 β-sitosterol, stigmasterol과 campesterol 등을 포함하는 phytosteol류, 당류, 아미노산, iridoid glycosides, inorganic elements 등이 보고되어 있으며, 이 중 iridoid glycosides는 free radical을 제거할 수 있는 항산화 효과를 가지고 있다고 보고되었다. Sukjihwang (Rehmanniae Radix Preparata) is a Korean herbal medicine used to soak the roots of Rehmannia glutinosa , which belongs to Hyeonsam family, and soak them in red wine. It has been used to treat symptoms such as heat, sore throat, and thirst that are caused by the weakness of the body among various chronic diseases. In addition, according to the processing method of the drug, it is classified as raw, sulfur and dried sulfur. Phytosteols, sugars, amino acids, iridoid glycosides and inorganic elements, including β-sitosterol, stigmasterol and campesterol, have been reported. Reported.

가시오가피(Eleutherococcus senticosus)는 두릅나무과(Araliaceae)에 속하며 뿌리와 줄기 및 가지의 껍질을 한방에서 약재로 사용하고 있다. 가시오가피는 자양강장, 강정, 진경 및 신진대사 활성작용이 있는 생약으로, 위궤양의 억제, 항염작용, 면역억제작용등의 효과가 있다고 알려져 있다.Gasiohgapi (Eleutherococcus senticosus) has used the roots and bark of the trunk and branches belonging to Araliaceae (Araliaceae) as in herbal medicine. Prickly ginseng is a herbal medicine with nourishing tonic, gangjeong, jingyeong and metabolic activity, and is known to have an effect of inhibiting gastric ulcer, anti-inflammatory and immunosuppressive effects.

본 발명자들은 종래 문헌에 기초한 관절염에 효과적인 천연 추출물을 제조하기 위해 예의 연구를 거듭한 결과, 휴대가 간편하고 복용이 용이할뿐만 아니라 약리적 효과에는 큰 영향력을 미치지 아니한 제품의 형태로서 생약젤리를 개발하고 본 발명에 이르게 되었다.The present inventors have intensively researched to prepare natural extracts effective for arthritis based on the conventional literature, and as a result, they have developed the herbal jelly as a product form that is not only portable and easy to take, but also does not have a great influence on the pharmacological effect. The present invention has been reached.

따라서 본 발명의 목적은 관절염에 효과적인 삼칠, 숙지황 및 가시오가피의 천연 추출물을 이용하여 제조된 생약젤리의 제조 방법을 제공하는 것이다.Therefore, it is an object of the present invention to provide a method for preparing herbal jelly prepared using natural extracts of Samchil, Sukjihwang and thorny opiaceum effective for arthritis.

또한 본 발명의 다른 목적은 상기의 제조방법으로 제조된 생약젤리를 제공하는 것이다.Another object of the present invention is to provide a herbal jelly prepared by the above production method.

상기와 같은 본 발명의 목적은 삼칠, 숙지황 및 가시오가피를 생약 원료로 하여 농축액으로 제조한 후, 이를 겔화제 및 기타 첨가제를 최적 성분으로 혼합하여 겔화시키고, 관능검사를 통해 최적 배합비를 확정함으로써 달성되었다.The object of the present invention as described above was achieved by preparing a concentrate as a raw material raw material, Shamil, Sukji sulfur and thorny opiaceous, then gelling and mixing the gelling agent and other additives as the optimum component, and confirmed the optimum compounding ratio through the sensory test .

본 발명은 삼칠, 숙지황 및 가시오가피를 주성분으로 하는 한방소재 생약젤리의 제조방법을 제공한다.The present invention provides a method for manufacturing herbal herbal medicine jelly containing Samchil, Sukji sulfur and thorny scabies as main ingredients.

본 발명에 따른 생약젤리의 제조 방법은 The manufacturing method of the herbal jelly according to the present invention

삼칠, 숙지황 및 가시오가피를 조분쇄하여 혼합하는 단계;Coarsely pulverizing and mixing the samchil, smutji sulfur and thorns

상기 혼합물에 10배수의 정제수를 가한 후, 열수 추출하고, 여과기로 여과하여 생액 혼합물 농축액을 제조하는 단계; Adding 10-fold purified water to the mixture, extracting hot water, and filtering with a filter to prepare a concentrate of a liquid solution mixture;

카파-카라기난, 글루코만난, L.B.G. 및 아이오타-카라기난를 혼합한 후, 정제수를 혼합하고, 교반하면서 90℃까지 가열하여 겔화제 용액을 제조하는 단계;Kappa-carrageenan, glucomannan, L.B.G. And mixing the iota-carrageenan, then mixing purified water and heating to 90 ° C. while stirring to prepare a gelling solution.

상기 겔화제와 생약 혼합물 농축액, 구연산 나트륨, 염화 칼륨, 스테비텐 후레쉬 및 자몽종자 추출물을 혼합하는 단계; 및Mixing the gelling agent and the herbal mixture concentrate, sodium citrate, potassium chloride, stebitene fresh and grapefruit seed extract; And

상기 혼합물을 중탕 살균하고, 냉각시키는 단계Sterilizing the mixture with water and cooling

로 이루어진다..

상기 본 발명에 따른 방법에 있어서, 삼칠, 숙지황 및 가시오가피의 혼합비는 바람직하게는 5:4:1이다. In the method according to the present invention, the mixing ratio of ginseng, succinct and yellow barley is preferably 5: 4: 1.

또한 본 발명에 따른 방법에 있어서, 겔화제 혼합물은 바람직하게는 카파-카라기난 65 내지 70 중량%, 글루코만난 3.5 내지 4.0 중량%, L.B.G. 11.0 내지 11.5 중량% 및 아이오타-카라기난 15 내지 20 중량%를 혼합되어 제조된다,.Also in the process according to the invention, the gelling agent mixture is preferably 65 to 70% by weight kappa-carrageenan, 3.5 to 4.0% by weight glucomannan, L.B.G. Prepared by mixing 11.0 to 11.5 weight percent and 15 to 20 weight percent of iota-carrageenan.

또한 본 발명에 따른 방법에 있어서, 생약젤리는 바람직하게는 겔화제 28 내지 33 중량%와 생약 혼합물 농축액 60 내지 65 중량%, 구연산 나트륨 1.5 내지 2.0 중량%, 염화 칼륨 4.0 내지 4.5 중량%, 스테비텐 후레쉬 0.5 내지 1.0 중량 % 및 자몽종자 추출물 0.5 내지 0.6 중량%를 혼합되어 제조된다.Also in the process according to the invention, the herbal jelly is preferably 28 to 33% by weight of the gelling agent and 60 to 65% by weight of the herbal mixture concentrate, 1.5 to 2.0% by weight of sodium citrate, 4.0 to 4.5% by weight of potassium chloride, stebitene It is prepared by mixing 0.5 to 1.0% by weight fresh flash and 0.5 to 0.6% by weight grapefruit seed extract.

본 발명에 있어서, 카파-카라기난, 글루코만난 및 L.B.G(Locost Bean Gum)는 겔화제로서 작용을 하며, 아이오타-카라기난은 겔화제인 동시에 이수방지제로서의 작용을 하고, 구연산 나트륨은 산도조절제, 스테비텐 후레쉬는 감미제, 자몽종자추출물은 천연 항균제 및 염화칼륨은 겔화 보조제로서 작용을 한다.In the present invention, kappa-carrageenan, glucomannan and LBG (Locost Bean Gum) act as a gelling agent, iota-carrageenan acts as a gelling agent and anti-digestion agent, sodium citrate is acidity regulator, steviten fresh Sweeteners and grapefruit seed extracts act as natural antibacterial agents and potassium chloride as a gelling aid.

또한 본 발명은 상기와 같은 방법으로 제조된 삼칠, 숙지황 및 가시오가피의 혼합 농축액을 유효성분으로 함유하는 한방소재 생액젤리를 제공한다.In another aspect, the present invention provides a herbal liquid raw liquid jelly containing a mixed concentrate of Samchil, Sukji sulfur and thorny ogapi prepared by the method as an active ingredient.

상기 본 발명에 따른 생약젤리는 바람직하게는 삼칠, 숙지황 및 가시오가피의 혼합 비율이 5:4:1인 것을 특징으로 한다.Herbal jelly according to the present invention is preferably characterized in that the mixing ratio of Shamil, Sukji sulfur and thorny scabies 5: 5: 1.

본 발명에 따른 한방소재 생약젤리는 생약 성분인 삼칠, 숙지황 및 가시오가피를 주성분으로 하고, 겔화 성분, 감미제, 천연 항균제 등을 혼합하여 겔화시켜 젤리로 제조됨으로써, 복용이 편리하고 휴대가 간편하여, 관절염에 효과가 있다고 알려진 삼칠, 숙지황 및 가시오가피를 보다 효과적으로 복용할 수 있는 효과가 있어, 식품 산업상 매우 유용한 발명인 것이다.Herbal herbal medicine jelly according to the present invention as a main ingredient in the herbal medicines Samchil, succinate and thorny opipi, and gelled by mixing the gelling ingredients, sweeteners, natural antibacterial agents, etc. to be prepared as a jelly, easy to take and easy to carry, arthritis It is effective to take Samchil, Sukji sulfur and thorny opipi, which is known to be effective against, and is a very useful invention in the food industry.

이하에서 본 발명의 바람직한 실시형태를 하기의 실시예를 참고로 보다 구체적으로 설명한다. 하지만 본 발명의 범위가 이러한 실시예에 한정되는 것은 아니다.Hereinafter, preferred embodiments of the present invention will be described in more detail with reference to the following examples. However, the scope of the present invention is not limited to these examples.

실시예 1 : 생약 추출물의 제조Example 1 Preparation of Herbal Extracts

삼칠과 숙지황, 가시오가피를 1차 조분쇄하여 5:4:1의 비율로 혼합하였다. 상기 혼합물에 10배수의 정제수를 가하고, 95℃에서 8시간 열수 추출하여 퍼라이트(입도 : #60 24%, #80 15%, #100 16%, #140 14%, #200 11%)로 코팅된 여과기로 여과를 실시하였다. Ssamchil, Sukjihwang, and thorny oak bark were firstly ground and mixed at a ratio of 5: 4: 1. 10 times of purified water was added to the mixture, and hot water extracted at 95 ° C. for 8 hours, coated with perlite (particle size: # 60 24%, # 80 15%, # 100 16%, # 140 14%, # 200 11%). Filtration was carried out with a filter.

한편, 상기 생약 혼합물을 효소 분해의 병행 방법으로 추출하였으며, 그 지표물질의 용출정도는 큰 차이가 없으며, 수율 역시 극명한 차이를 보이지는 않았다(데이터는 나타내지 않음)On the other hand, the herbal mixture was extracted by the method of enzymatic degradation in parallel, the elution degree of the indicator material was not significantly different, the yield also showed no significant difference (data not shown)

상기에서 수득한 여과된 추출액을 감압농축기를 사용하여 50Brix까지 농축하 였다. The filtered extract obtained above was concentrated to 50 Brix using a vacuum concentrator.

실시예 2 : 생약젤리의 제조Example 2 Preparation of Herbal Jelly

상기 실시예 1에서 제조한 생약 혼합물 농축액을 이용하여 생액젤리를 제조하기 위하여, 상기 생약 혼합물 농축액과 해조류 코토니에서 추출한 물질인 카파-카라기난, 정제곤약 베이스의 글루코만난, L.B.G(Locost Bean Gum), 해조류 스피노즘에서 추출한 물질인 아이오타-카라기난, 구연산 나트륨, 스테비텐 후레쉬, 자몽종자추출물 및 염화칼륨을 하기 표 1과 같은 비율로 배합하여 5 가지의 혼합물을 제조하였다.In order to prepare a raw liquid jelly using the herbal mixture concentrate prepared in Example 1, kappa-carrageenan, a substance extracted from the crude herb mixture concentrate and seaweed cortoni, glucomannan based on the purified konnyaku, LBG (Locost Bean Gum), seaweed A mixture of iota-carrageenan, sodium citrate, steviten fresh, grapefruit seed extract, and potassium chloride, which are extracted from the spinome, was mixed in the ratio as shown in Table 1 to prepare five mixtures.

<표 1>TABLE 1

Figure 112008067152788-PAT00001
Figure 112008067152788-PAT00001

상기에서 카파-카라기난, 글루코만난 및 L.B.G(Locost Bean Gum)는 겔화제로서 작용을 하며, 아이오타-카라기난은 겔화제인 동시에 이수방지제로서의 작용을 하고, 구연산 나트륨은 산도조절제, 스테비텐 후레쉬는 감미제, 자몽종자추출물은 천연 항균제 및 염화칼륨은 겔화 보조제로서 작용을 한다.In the above kappa-carrageenan, glucomannan and LBG (Locost Bean Gum) acts as a gelling agent, iota-carrageenan acts as a gelling agent and anti-digestion agent, sodium citrate acidity regulator, steviten freshener sweetener, grapefruit Seed extract acts as a natural antibacterial agent and potassium chloride as a gelling aid.

우선, 겔화제로서 카파-카라기난, 글루코만난 L.B.G. 및 아이오타-카라기난과 정제수를 혼합하고, 교반하면서 90℃까지 가열하여 분말을 완전히 용해시켰다. 상기 혼합 겔화제를 50℃까지 냉각시키고, 이를 생약 혼합물 농축액, 구연산 나트륨, 염화 칼륨, 스테비텐 후레쉬 및 자몽종자 추출물과 혼합하고, 20분 동안 교반하였다. 상기 혼합물을 용기에 충전하고 85℃에서 40분 동안 중탕 살균하였다. 이를 상온에서 냉각시켜 최종 생약 젤리를 제조하였다.First, kappa-carrageenan and glucomannan L.B.G. And iota-carrageenan and purified water were mixed and heated to 90 ° C. while stirring to dissolve the powder completely. The mixed gelling agent was cooled to 50 ° C. and mixed with the herbal mixture concentrate, sodium citrate, potassium chloride, stebitene fresh and grapefruit seed extract and stirred for 20 minutes. The mixture was charged to a vessel and sterilized in a bath at 85 ° C. for 40 minutes. This was cooled to room temperature to prepare the final herbal jelly.

실험예 1: 관능검사Experimental Example 1: sensory test

상기 실시예 2에서 5 가지 배합비로 제조된 생약 젤리에 대한 관능검사를 (재)대구테크노파크 바이오산업지원센터의 연구원11명과 영남대학교 식품가공학전공 대학원생 3명, 일심제약의 연구원 3명 등 17명이 실시하였다. 그 결과를 하기 표 2 및 도 2에 나타내었다.In Example 2, the sensory test on the herbal jelly prepared at the five compounding ratios was carried out by 17 researchers including 11 researchers at Daegu Technopark Bioindustry Support Center, 3 graduate students at Yeungnam University, and 3 researchers at Ilsim Pharmaceutical. Was carried out. The results are shown in Table 2 and FIG. 2.

<표 2>TABLE 2

Figure 112008067152788-PAT00002
Figure 112008067152788-PAT00002

* 가장 좋음 5점, 좋음 4점, 보통 3점, 나쁨 2점, 아주나쁨 1점. * Best 5, Good 4, Moderate 3, Poor 2, Poor 1.

상기 표 2에 나타낸 바와 같이, Je496의 경우 겔이 단단하고 퍼석하였으며, Je539의 경우 퍼석함과 함께 탄력이 부족하였고, Je136의 경우 전반적인 겔의 성질 은 양호하나 약간의 탄성이 부족하였다. JE972의 경우 전체적으로 양호하였으며, Je664의 경우 겔의 식감이 강하였다. As shown in Table 2, in the case of Je496, the gel was hard and permeable. In the case of Je539, the gel was poor and the elasticity was insufficient. In the case of Je136, the overall gel properties were good, but the elasticity was slight. In the case of JE972, the overall quality was good. In the case of Je664, the gel texture was strong.

도 1은 본 발명에 따른 생약젤리의 제조방법을 개략적으로 나타낸 공정도이다.1 is a process diagram schematically showing a method of manufacturing herbal jelly according to the present invention.

도 2는 본 발명에 따른 생약젤리에 대한 관능검사 결과를 나타낸 그래프이다.Figure 2 is a graph showing the sensory test results for the herbal jelly according to the present invention.

Claims (3)

삼칠, 숙지황 및 가시오가피를 조분쇄하여 5:4:1의 비율로 혼합하는 단계;Coarsely pulverizing samchil, sorghum and thorns and mixing in a ratio of 5: 4: 1; 상기 혼합물에 10배수의 정제수를 가한 후, 열수 추출하고, 여과기로 여과하여 50Brix 생액 혼합물 농축액을 제조하는 단계; Adding 10-fold purified water to the mixture, followed by hot water extraction and filtration with a filter to prepare a 50 Brix raw liquid mixture concentrate; 카파-카라기난 65 내지 70 중량%, 글루코만난 3.5 내지 4.0 중량%, L.B.G. 11.0 내지 11.5 중량% 및 아이오타-카라기난 15 내지 20 중량%를 혼합한 후, 정제수를 혼합하고, 교반하면서 90℃까지 가열하여 겔화제 용액을 제조하는 단계;Kappa-carrageenan 65 to 70% by weight, glucomannan 3.5 to 4.0% by weight, L.B.G. 11.0 to 11.5% by weight and 15 to 20% by weight of iota-carrageenan, followed by mixing purified water and heating to 90 ° C. while stirring to prepare a gelling agent solution; 상기 겔화제 28 내지 33 중량%와 생약 혼합물 농축액 60 내지 65 중량%, 구연산 나트륨 1.5 내지 2.0 중량%, 염화 칼륨 4.0 내지 4.5 중량%, 스테비텐 후레쉬 0.5 내지 1.0 중량 % 및 자몽종자 추출물 0.5 내지 0.6 중량%를 혼합하는 단계; 및The gelling agent 28 to 33% by weight and the herbal mixture concentrate 60 to 65% by weight, sodium citrate 1.5 to 2.0% by weight, potassium chloride 4.0 to 4.5% by weight, steviten fresh 0.5 to 1.0% by weight and grapefruit seed extract 0.5 to 0.6% by weight Mixing%; And 상기 혼합물을 중탕 살균하고, 냉각시키는 단계Sterilizing the mixture with water and cooling 로 이루어진 한방소재 생약젤리의 제조 방법.Method of manufacturing herbal herbal medicine jelly. 제1항의 방법으로 제조되어, 삼칠, 숙지황 및 가시오가피의 혼합 농축액을 유효성분으로 함유하는 한방소재 생액젤리.Herbal raw material liquid jelly prepared by the method of claim 1, containing a mixed concentrate of Samchil, Sukji sulfur and thorn oak as an active ingredient. 제2항에 있어서, 상기 삼칠, 숙지황 및 가시오가피의 혼합 비율이 5:4:1인 것을 특징으로 하는 한방소재 생액젤리.The herbal liquid raw liquid jelly according to claim 2, wherein the mixing ratio of Shamil, Sukji sulfur and thorny scabies is 5: 4: 1.
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104800260A (en) * 2015-05-11 2015-07-29 云南文山坤七药业股份有限公司 Radix-notoginseng superfine powder and preparation method thereof
KR20190104748A (en) * 2018-03-02 2019-09-11 동신대학교산학협력단 Preparation Method for Jelly Using Panax ginseng Sprout
KR102223638B1 (en) * 2020-07-28 2021-03-04 곽병상 PSA stabilizer in blood comprising antimicrobial composition containing silver compound and complexing agent and Panax notoginseng extract

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104800260A (en) * 2015-05-11 2015-07-29 云南文山坤七药业股份有限公司 Radix-notoginseng superfine powder and preparation method thereof
KR20190104748A (en) * 2018-03-02 2019-09-11 동신대학교산학협력단 Preparation Method for Jelly Using Panax ginseng Sprout
KR102223638B1 (en) * 2020-07-28 2021-03-04 곽병상 PSA stabilizer in blood comprising antimicrobial composition containing silver compound and complexing agent and Panax notoginseng extract

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