KR20100010509A - 면역자극 효과를 갖는 ａ 클래스 올리고뉴클레오타이드 - Google Patents
면역자극 효과를 갖는 ａ 클래스 올리고뉴클레오타이드 Download PDFInfo
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- KR20100010509A KR20100010509A KR1020097026396A KR20097026396A KR20100010509A KR 20100010509 A KR20100010509 A KR 20100010509A KR 1020097026396 A KR1020097026396 A KR 1020097026396A KR 20097026396 A KR20097026396 A KR 20097026396A KR 20100010509 A KR20100010509 A KR 20100010509A
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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| US60/930,580 | 2007-05-17 |
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| KR20100010509A true KR20100010509A (ko) | 2010-02-01 |
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| BR (1) | BRPI0811621A2 (enExample) |
| CA (1) | CA2687441A1 (enExample) |
| IL (1) | IL202096A0 (enExample) |
| MX (1) | MX2009012482A (enExample) |
| RU (1) | RU2009142211A (enExample) |
| TW (1) | TW200916115A (enExample) |
| WO (1) | WO2008142509A2 (enExample) |
| ZA (1) | ZA200908062B (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019240504A1 (en) * | 2018-06-12 | 2019-12-19 | Am Sciences Co., Ltd. | Modified oligonucleotides for inhibition of target gene expression |
| WO2019240503A1 (ko) * | 2018-06-12 | 2019-12-19 | 주식회사 에이엠사이언스 | B형 간염 예방 또는 치료용 조성물 |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030026782A1 (en) * | 1995-02-07 | 2003-02-06 | Arthur M. Krieg | Immunomodulatory oligonucleotides |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| US7276489B2 (en) * | 2002-10-24 | 2007-10-02 | Idera Pharmaceuticals, Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends |
| RU2302865C2 (ru) | 2002-04-04 | 2007-07-20 | Коли Фармасьютикал Гмбх | Иммуностимулирующие g, u-содержащие олигорибонуклеотиды |
| US20040053880A1 (en) | 2002-07-03 | 2004-03-18 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| AR040996A1 (es) | 2002-08-19 | 2005-04-27 | Coley Pharm Group Inc | Acidos nucleicos inmunoestimuladores |
| BR0315810A (pt) | 2002-10-29 | 2005-09-13 | Coley Pharmaceutical Group Ltd | Uso de oligonucleotìdeos cpg no tratamento de infecção por vìrus da hepatite c |
| CA2540949A1 (en) | 2003-10-30 | 2005-05-12 | Coley Pharmaceutical Gmbh | C-class oligonucleotide analogs with enhanced immunostimulatory potency |
| MX2009003398A (es) | 2006-09-27 | 2009-08-12 | Coley Pharm Gmbh | Analogos de oligonucleotidos cpg que contienen analogos t hidrofobos con actividad inmunoestimuladora mejorada. |
| CN103025351B (zh) * | 2010-05-28 | 2016-08-24 | 佐蒂斯比利时股份有限公司 | 包含胆固醇和作为唯一的佐剂-载剂分子的cpg的疫苗 |
| EP2471926A3 (en) | 2010-12-30 | 2012-07-11 | Intervet International BV | Immunostimulatory oligodeoxynucleotides |
| JP6453212B2 (ja) * | 2012-07-13 | 2019-01-16 | ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． | キラル制御 |
| US11268098B2 (en) | 2014-12-25 | 2022-03-08 | National Institutes Of Biomedical Innovation, Health And Nutrition | Non-aggregating immunostimulatory oligonucleotides |
| JP6698069B2 (ja) * | 2015-03-20 | 2020-05-27 | 国立研究開発法人医薬基盤・健康・栄養研究所 | 免疫賦活活性を有するＣｐＧスペーサーオリゴヌクレオチド含有複合体及びその用途 |
| EP3752194A4 (en) | 2018-02-13 | 2022-03-16 | Checkmate Pharmaceuticals, Inc. | ANTI-TUMOR IMMUNOTHERAPY COMPOSITIONS AND METHODS |
| US12084655B2 (en) | 2018-04-09 | 2024-09-10 | Checkmate Pharmaceuticals | Packaging oligonucleotides into virus-like particles |
| WO2023034853A2 (en) * | 2021-08-31 | 2023-03-09 | City Of Hope | Oligonucleotides having 6-thio-2'-deoxyguanosine residues and uses thereof |
| CN113517062B (zh) * | 2021-09-14 | 2021-12-10 | 青岛未来移动医疗科技有限公司 | 一种智能疫苗雾化系统及使用方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3854480A (en) * | 1969-04-01 | 1974-12-17 | Alza Corp | Drug-delivery system |
| US4469863A (en) * | 1980-11-12 | 1984-09-04 | Ts O Paul O P | Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof |
| US4675189A (en) * | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
| US5023243A (en) * | 1981-10-23 | 1991-06-11 | Molecular Biosystems, Inc. | Oligonucleotide therapeutic agent and method of making same |
| US4452775A (en) * | 1982-12-03 | 1984-06-05 | Syntex (U.S.A.) Inc. | Cholesterol matrix delivery system for sustained release of macromolecules |
| US5075109A (en) * | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| US5133974A (en) * | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
| DE4321946A1 (de) * | 1993-07-01 | 1995-01-12 | Hoechst Ag | Methylphosphonsäureester, Verfahren zu deren Herstellung und deren Verwendung |
| US5658738A (en) * | 1994-05-31 | 1997-08-19 | Becton Dickinson And Company | Bi-directional oligonucleotides that bind thrombin |
| DE69535036T3 (de) | 1994-07-15 | 2011-07-07 | The University of Iowa Research Foundation, IA | Immunomodulatorische oligonukleotide |
| US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US5736152A (en) * | 1995-10-27 | 1998-04-07 | Atrix Laboratories, Inc. | Non-polymeric sustained release delivery system |
| AU738513B2 (en) * | 1997-02-28 | 2001-09-20 | University Of Iowa Research Foundation, The | Use of nucleic acids containing unmethylated CpG dinucleotide in the treatment of LPS-associated disorders |
| EP1003531B1 (en) | 1997-05-20 | 2007-08-22 | Ottawa Health Research Institute | Processes for preparing nucleic acid constructs |
| ES2284247T3 (es) | 1998-04-03 | 2007-11-01 | University Of Iowa Research Foundation | Metodos y productos para estimular el sistema inmunitario usando oligonucleotidos y citoquinas inmunoterapeuticos. |
| EP1187629B1 (en) * | 1999-04-19 | 2004-09-22 | GlaxoSmithKline Biologicals S.A. | Adjuvant composition comprising saponin and an immunostimulatory oligonucleotide |
| US6949520B1 (en) * | 1999-09-27 | 2005-09-27 | Coley Pharmaceutical Group, Inc. | Methods related to immunostimulatory nucleic acid-induced interferon |
| DE60029460T3 (de) | 1999-09-27 | 2011-02-10 | Coley Pharmaceutical Gmbh | Verfahren mittels durch nukleinsäuren induziertes immunostimulatorisches interferon |
| CN1604795B (zh) | 2001-08-17 | 2010-05-26 | 科勒制药股份公司 | 具有提高的活性的组合基序免疫刺激寡肽 |
| WO2006091915A2 (en) * | 2005-02-24 | 2006-08-31 | Coley Pharmaceutical Group, Inc. | Immunostimulatory oligonucleotides |
| RU2007141402A (ru) * | 2005-04-08 | 2009-05-20 | Коли Фармасьютикал Груп, Инк. (Us) | Способы лечения астмы, осложненной инфекционными заболеваниями |
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2008
- 2008-05-15 RU RU2009142211/15A patent/RU2009142211A/ru not_active Application Discontinuation
- 2008-05-15 BR BRPI0811621-0A2A patent/BRPI0811621A2/pt not_active IP Right Cessation
- 2008-05-15 EP EP08750940A patent/EP2160199A2/en not_active Withdrawn
- 2008-05-15 AU AU2008252577A patent/AU2008252577A1/en not_active Abandoned
- 2008-05-15 MX MX2009012482A patent/MX2009012482A/es unknown
- 2008-05-15 WO PCT/IB2008/001199 patent/WO2008142509A2/en not_active Ceased
- 2008-05-15 US US12/600,364 patent/US20100285041A1/en not_active Abandoned
- 2008-05-15 KR KR1020097026396A patent/KR20100010509A/ko not_active Ceased
- 2008-05-15 CA CA002687441A patent/CA2687441A1/en not_active Abandoned
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- 2008-05-16 AR ARP080102108A patent/AR066626A1/es unknown
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2009
- 2009-11-12 IL IL202096A patent/IL202096A0/en unknown
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019240504A1 (en) * | 2018-06-12 | 2019-12-19 | Am Sciences Co., Ltd. | Modified oligonucleotides for inhibition of target gene expression |
| WO2019240503A1 (ko) * | 2018-06-12 | 2019-12-19 | 주식회사 에이엠사이언스 | B형 간염 예방 또는 치료용 조성물 |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2009142211A (ru) | 2011-05-27 |
| JP2009035530A (ja) | 2009-02-19 |
| WO2008142509A2 (en) | 2008-11-27 |
| WO2008142509A3 (en) | 2009-03-05 |
| CA2687441A1 (en) | 2008-11-27 |
| BRPI0811621A2 (pt) | 2014-10-21 |
| AR066626A1 (es) | 2009-09-02 |
| US20100285041A1 (en) | 2010-11-11 |
| TW200916115A (en) | 2009-04-16 |
| EP2160199A2 (en) | 2010-03-10 |
| CN101678098A (zh) | 2010-03-24 |
| IL202096A0 (en) | 2010-06-16 |
| MX2009012482A (es) | 2009-12-02 |
| AU2008252577A1 (en) | 2008-11-27 |
| ZA200908062B (en) | 2010-06-30 |
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