KR20090129981A - 항혈전 활성을 갖는 이미노이미다조피리딘 유도체 - Google Patents

항혈전 활성을 갖는 이미노이미다조피리딘 유도체 Download PDF

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Publication number
KR20090129981A
KR20090129981A KR1020097002137A KR20097002137A KR20090129981A KR 20090129981 A KR20090129981 A KR 20090129981A KR 1020097002137 A KR1020097002137 A KR 1020097002137A KR 20097002137 A KR20097002137 A KR 20097002137A KR 20090129981 A KR20090129981 A KR 20090129981A
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KR
South Korea
Prior art keywords
alkyl
alkylene
formula
het
aryl
Prior art date
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Abandoned
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KR1020097002137A
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English (en)
Korean (ko)
Inventor
우베 하이넬트
아르민 호프마이슈터
외르크 체흐
Original Assignee
사노피-아벤티스
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Publication of KR20090129981A publication Critical patent/KR20090129981A/ko
Abandoned legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020097002137A 2006-08-02 2007-07-18 항혈전 활성을 갖는 이미노이미다조피리딘 유도체 Abandoned KR20090129981A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006036023.0 2006-08-02
DE102006036023A DE102006036023A1 (de) 2006-08-02 2006-08-02 Imino-imidazo-pyridinderivate mit antithrombotischer Aktivität

Publications (1)

Publication Number Publication Date
KR20090129981A true KR20090129981A (ko) 2009-12-17

Family

ID=38884850

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020097002137A Abandoned KR20090129981A (ko) 2006-08-02 2007-07-18 항혈전 활성을 갖는 이미노이미다조피리딘 유도체

Country Status (23)

Country Link
US (1) US7863269B2 (https=)
EP (1) EP2054412B1 (https=)
JP (1) JP5149897B2 (https=)
KR (1) KR20090129981A (https=)
CN (1) CN101495478B (https=)
AR (1) AR062158A1 (https=)
AT (1) ATE450537T1 (https=)
AU (1) AU2007280780B2 (https=)
BR (1) BRPI0714599A2 (https=)
CA (1) CA2663332C (https=)
CL (1) CL2007002240A1 (https=)
DE (2) DE102006036023A1 (https=)
DK (1) DK2054412T3 (https=)
DO (1) DOP2007000120A (https=)
ES (1) ES2336044T3 (https=)
IL (1) IL196789A (https=)
MX (1) MX2009000408A (https=)
MY (1) MY148611A (https=)
NO (1) NO20090741L (https=)
PE (1) PE20080687A1 (https=)
PT (1) PT2054412E (https=)
TW (1) TWI400240B (https=)
WO (1) WO2008014888A2 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS52264B (sr) * 2008-02-05 2012-10-31 Sanofi Triazolopiridazini kao inhibitori par1, njihovo dobijanje i upotreba kao lekova
US20160040247A1 (en) 2013-03-15 2016-02-11 Fundació Institut De Recerca Biomèdica (Irb Barcelona) Method for the diagnosis, prognosis, and tratment of cancer metastasis

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5124517B1 (https=) * 1971-03-15 1976-07-24
DE2221796A1 (de) 1972-05-04 1973-11-15 Kraemer Kg Wilhelm Batteriebehaelter fuer stabbatterien
JPS60161986A (ja) * 1983-12-24 1985-08-23 Nippon Soda Co Ltd イミダゾ(1,5−a)ピリジン−3−オン誘導体及びその製造方法
US6063847A (en) * 1997-11-25 2000-05-16 Schering Corporation Thrombin receptor antagonists
US7488742B2 (en) * 2000-06-15 2009-02-10 Schering Corporation Thrombin receptor antagonists
EP1394152A4 (en) * 2001-04-19 2005-02-02 Eisai Co Ltd 2-IMINOIMIDAZOLE DERIVATIVES (1)
BRPI0309309B8 (pt) 2002-04-16 2021-05-25 Merck Sharp & Dohme antagonistas de receptor de trombina tricíclicos
CN100439336C (zh) 2003-02-19 2008-12-03 卫材R&D管理有限公司 制备环状苯甲脒衍生物的方法
DE10353205A1 (de) 2003-11-13 2005-06-16 Aventis Pharma Deutschland Gmbh Ortho-substituierte Pentafluorsulfuranyl-Benzole, Verfahren zu ihrer Herstellung sowie ihre Verwendung als wertvolle Synthese-Zwischenstufen
US7317124B2 (en) * 2003-11-13 2008-01-08 Sanofi-Aventis Deutschland Gmbh Ortho-substituted pentafluorosulfanylbenzenes, process for their preparation and their use as valuable synthetic intermediates

Also Published As

Publication number Publication date
IL196789A (en) 2012-07-31
JP2009545542A (ja) 2009-12-24
DE502007002219D1 (de) 2010-01-14
DE102006036023A1 (de) 2008-02-07
JP5149897B2 (ja) 2013-02-20
IL196789A0 (en) 2009-11-18
US20090192150A1 (en) 2009-07-30
ATE450537T1 (de) 2009-12-15
ES2336044T3 (es) 2010-04-07
BRPI0714599A2 (pt) 2013-04-09
HK1135694A1 (en) 2010-06-11
EP2054412A2 (de) 2009-05-06
DK2054412T3 (da) 2010-04-19
NO20090741L (no) 2009-02-16
AR062158A1 (es) 2008-10-22
DOP2007000120A (es) 2008-02-29
TWI400240B (zh) 2013-07-01
CA2663332A1 (en) 2008-02-07
WO2008014888A2 (de) 2008-02-07
EP2054412B1 (de) 2009-12-02
PE20080687A1 (es) 2008-07-24
PT2054412E (pt) 2010-02-04
CA2663332C (en) 2015-06-02
AU2007280780A1 (en) 2008-02-07
MX2009000408A (es) 2009-01-27
TW200821308A (en) 2008-05-16
WO2008014888A3 (de) 2008-06-12
CN101495478B (zh) 2013-03-27
CL2007002240A1 (es) 2008-02-08
MY148611A (en) 2013-05-15
US7863269B2 (en) 2011-01-04
CN101495478A (zh) 2009-07-29
AU2007280780B2 (en) 2012-03-29

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Patent event date: 20090202

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Patent event code: PA02012R01D

Patent event date: 20120717

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Patent event date: 20140120

Patent event code: PE09021S01D

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PE0701 Decision of registration

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Patent event date: 20140729

NORF Unpaid initial registration fee
PC1904 Unpaid initial registration fee