KR20090108812A - Anti-aging cosmetic composition for skin - Google Patents

Abstract

PURPOSE: A cosmetic composition for preventing skin aging is provided to prolong life of skin cell and recover skin grossiness. CONSTITUTION: A cosmetic compositio for preventing skin aging comprises 1.0-3.0 weight% of apple stem cell, 0.5-1.0 weight% of Hibiscus seed extract or 0.5-1.0 weight% of argane oil based on the total weight as an effective ingredient.

Description

Anti-aging cosmetic composition for skin

The present invention is an apple stem cell, Hibiscus esculentus ) Contains seed extract and argan oil to resolve fine lines, dullness, crumbness, rough skin texture, and promote collagen synthesis by protecting growth factor, which decreases with age. The present invention relates to a cosmetic composition for preventing skin aging that enhances and exhibits an excellent effect on the recovery of skin radiance.

Skin is the body's primary protective film that protects internal organs from changes in temperature and humidity, and from stimuli from the external environment such as ultraviolet rays and pollutants, and plays an important role in maintaining homeostasis such as body temperature control. Like other organs of the human body, such skin gradually ages as a person ages, resulting in loss of skin elasticity, keratinization, wrinkle formation, blemishes, freckles, and black spots. The causes of skin aging can be broadly divided into two factors: internal factors caused by cell genetic variation and external factors such as ultraviolet light and humidity (Masamitsu Ichihashi, Fragrance Journal, Vol. 32, No 5, 24 ~ 30).

First, the structural changes of the skin according to aging, the thickness of the skin components epidermis, dermis and subcutaneous tissue becomes thin. In addition, the extracelluar matrix (ECM) component of dermal tissue responsible for skin elasticity and tension is changed. Collagen makes up about 70-80% of the total ECM. As aging progresses, the elasticity of the skin is greatly reduced due to a decrease in collagen and elastin. Various substances have been developed for the purpose of suppressing the reduction of collagen and elastin, and in particular, wrinkle-reducing or elasticity-reducing effects of retinoids such as retinol and retinoic acid are known (Dermatology therapy, 1998, 16, 357-364). However, these retinoids have a drawback that irritation occurs even when only a small amount is applied to the skin, and there is a problem of easily oxidative alteration when exposed to air due to instability. Accordingly, there has been a need for the development of active ingredients that can produce anti-aging effects without causing skin side effects.

Wounds hurt in childhood are easily healed without scars, but wounds after adulthood are slow and scarring. This change comes from the difference between the natural healing power of the skin and the degree of regeneration of the cells. The natural healing power of the skin and the regeneration of the cells are inherent characteristics of stem cells in the basement layer of the skin. Stem cells play an important role in maintaining homeostasis of living organisms, playing a key role in dealing with the regenerative and healing process entirely, while maintaining differentiation at regular intervals during human life.

It is known that about 2 ~ 7% of stem cells exist in the basement layer of the epidermis, and it is very sensitive to harmful environment inside and outside, and it loses stem cell performance as it gradually deteriorates with aging. It will gradually decrease. When skin stem cells lose or lose their capacity, the skin cells that are born and need to be replaced cannot be made well, and the skin's original regeneration is lost, causing various skin symptoms such as fine lines, dullness, crumbs, and rough skin. do. Therefore, in order to maintain healthy and beautiful skin, it is important to protect and maintain innate stem cells from these internal and external factors.

The present inventors maintain the skin stem cells to extend the life of the skin cells, protect the skin cells from various UV or stress, protect growth factors to promote the synthesis of collagen, etc. as an active ingredient that can make the skin younger As a result of the search, it was found that a mixture of plant stem cells, hibiscus seed extract, and argan oil can obtain excellent skin anti-aging effect and completed the present invention.

Accordingly, it is an object of the present invention to provide a skin composition for preventing skin aging containing plant stem cells, hibiscus seed extract, and argan oil having excellent efficacy of inhibiting skin aging as active ingredients.

In order to achieve the above object, the present invention provides a skin composition for preventing skin aging containing apple stem cells, hibiscus seed extract and argan oil as an active ingredient.

In addition, in the present invention, as an active ingredient, in addition to the above components, one or more selected from the group consisting of oat seed extract, hyaluronic acid, chitosan, soybean extract, polyglyceryl-8 stearate, ceramide, phytosphingosine and yeast extract Provided is a cosmetic composition for preventing skin aging.

The anti-aging cosmetic composition according to the present invention contains plant stem cells, hibiscus seed extract and argan oil as active ingredients to prolong skin cell life, restore skin density and gloss, and repair damaged skin to improve wrinkles. In addition, skin dullness and crumbness are improved to show excellent anti-aging effects.

The present invention provides a skin anti-aging cosmetic composition consisting of a mixture of apple stem cells, hibiscus seed extract and argan oil.

The anti-aging cosmetic composition according to the present invention preferably contains 1.0% to 3.0% by weight of apple stem cells, 0.5% to 1.0% by weight of hibiscus seed extract and 0.5% to 1.0% by weight of argan oil, based on the total weight of the composition. Do.

Hereinafter, the present invention will be described in more detail.

As skin ages, stem cell density decreases, resulting in poor skin regeneration, causing rough skin texture, and various skin symptoms such as reduced gloss. Aging skin can be improved through stem cell protection and activation.

When the plant is attacked or injured from the outside, the cells around the damaged tissue are returned to the regenerating baby cells (plant stem cells), which leads to an intensive and rapid wound regeneration process. Return to the original normal cell. Plant stem cells are rich in plant stem cell factors and various metabolites, which not only improve skin stem cell performance but also activate p63, an anti-aging protein, to extend the life of skin cells.

The p63 gene, known as one of the cancer suppressor genes, is also associated with aging. The lack of the p63 gene has been shown to promote aging, and studies have shown that removing p63 gene from mature mice has reduced premature life with premature phenomena. Therefore, p63 is said to be a gene that plays a basic biological role in the aging process. Rats born with no or completely p63 genes died early, and both pairs of p63 genes were removed from certain tissues, such as the skin of mature mice, resulting in hair loss, weight loss, and gradual curvature of the spine. Appears and the life is shortened. Aging and cancer are two sides of the same coin: cells stop dividing or not, or one of them, and the protein that the p63 gene makes on time, in the right cells, in the right amount must be kept in balance for tissues to live long without cancer This is done.

The method of obtaining the apple stem cells of the present invention is not very complicated. When the apple's outer surface is cut with a sharp cut, it attempts to regenerate due to the plant's unique response. At this time, the regeneration site is transferred to the medium plate to proliferate the cells through a general cell culture method. The cells multiply on the medium, yielding a large amount of apple stem cells. The reason why apples were chosen among many plants is that the stem cell proliferation of apples is faster than other plants and a large amount of stem cells can be obtained, which is suitable for use as a cosmetic raw material.

The anti-aging cosmetic composition according to the present invention preferably contains apple stem cells in an amount of 1.0% by weight to 3.0% by weight based on the total weight of the composition. This is because the apple stem cells show less efficacy at less than 1.0% by weight, and over 3.0% by weight, they exhibit the same efficacy as at 3.0% by weight or less.

Hibiscus esculentus ) Seed extract, a line factor, is a plant native to the equator and has been widely known for its relaxation and stimulation effects. Hibiscus seed extract has a raw material name of line factor, which is a unique name assigned by the raw material manufacturer. Hibiscus seed extract protects FGF-2 produced in fibroblasts and promotes collagen GAG synthesis to make young skin look younger. When FGF-2 is produced in fibroblasts, it binds to proteoglycans and stabilizes by binding to proteoglycans, which in turn binds to FGFR to regenerate skin, resulting in cell multiplication and collagen. And GAG synthesis.

Hibiscus seed extract is known to promote collagen synthesis by concentration, and when it contains 1%, it promotes collagen synthesis by about 18%, and when it contains 3%, it promotes collagen synthesis by about 23%. 2% GAG synthesis also promotes about 294% synthesis. When used at 1%, it is known to have 1.8 times and 1.3 times GAG synthesis effects than vitamin C and pentapeptide, respectively. Clinical trials showed that 3% hibiscus seed extract was used to improve 100% in the 50-60s compared to 3% vitamin C. In skin elasticity, there was about 37% improvement in the 50's and 60's. Wrinkle improvement showed that hibiscus seed extract was about 2.2 times more effective than vitamin C. After 42 days, the skin density of the 50s-60s was the same as that of the 40-50s, and the skin tissues of the 50s-60s were more improved than the 40s-50s.

Hibiscus seed extract is extracted by a known method, which is obtained by drying, grinding and extracting hibiscus seeds with water or an organic solvent. The organic solvent may be a polar solvent such as ethanol, butanol, acetone, or a non-polar solvent such as ether, hexane, benzene, chloroform, ethyl acetate, or a mixture thereof.

The anti-aging cosmetic composition according to the present invention preferably contains the hibiscus seed extract in an amount of 0.5% by weight to 1.0% by weight based on the total weight of the composition. If less than 0.5% by weight of the hibiscus seed extract is very small, when it exceeds 1.0% by weight is equivalent to less than 1.0% by weight.

Argan oil is high in tocopherols and forms a protective layer of skin cells that gives skin its softness and restores it. In addition, it instantly repairs damaged skin from the external environment, providing complete protection from the external environment. Argan oil also has a health-reducing effect as a food. Argan oil is rich in unsaturated fatty acids, which is excellent for curing heart disease, produces sperm in men, and is rich in phytosterol, a component that helps the brain's activity.

In addition to its health benefits, it has good health benefits. Known as a miracle-like extract that maintains youthfulness, it not only regenerates the skin but also strengthens the hair and nails. The skin moisturizing effect is 10 times higher than olive oil, and vitamin E is twice as antioxidant as olive oil. This is very excellent. Moroccan women have been using argan oil for centuries to protect their skin in the harsh climate of the desert. Argan oils produced in Morocco are all traditionally extracted by hand and are very environmentally friendly.

A common recipe for argan oil is Argania Spinosa ) knead the flour on the millstone, knead until oil bleeds by hand, collect the oil and extract the pure oil. On average, one tree of fruit is needed to extract one liter of oil, which is about 125 kg.

The anti-aging cosmetic composition according to the present invention preferably contains argan oil in an amount of 0.5% to 1.0% by weight based on the total weight of the composition. Less than 0.5% by weight of the argan oil appears to be very small, when the amount exceeds 1.0% by weight of the oil content is too much because the product itself is too oily.

In addition, the anti-aging cosmetic composition according to the present invention is selected from the group consisting of oat seed extract, hyaluronic acid, chitosan, soybean extract, polyglyceryl-8 stearate, ceramide, phytosphingosine, yeast extract with the three components It may further contain one or more kinds in an amount of 0.5% to 5.0% by weight relative to the total weight of the cosmetic composition. If the amount is less than 0.5% by weight, the efficacy of each component is very small, and when it exceeds 5.0% by weight, the efficacy is lowered by the cross reaction of different components.

The oat seed extract of the present invention imparts elasticity to the skin, hyaluronic acid, chitosan, soybean extract and yeast extract has the effect of moisturizing the skin and supplying nutrients. Polyglyceryl-8 stearate, ceramide, and phytosphingosine energize and energize the skin.

The anti-aging cosmetic composition according to the present invention is not particularly limited in its formulation. For example, supple cosmetics, astringent cosmetics, nourishing cosmetics, nourishing cream, massage cream, essence, eye cream, eye essence, cleansing cream, cleansing foam, cleansing water, pack, powder, body lotion, body cream, body oil, body It may be formulated as an essence, a makeup base or a foundation, or the like, or may be formulated as a cosmetic such as an anti-aging cosmetic or an ointment and a patch.

Hereinafter, although an Example and a comparative example demonstrate this invention more concretely, this invention is not limited only to these examples.

Example 1 and Comparative Example 1

To Example 1 and Comparative Example 1 was prepared in the cosmetic formulation with the composition of Table 1 (unit: wt%). Hibiscus seed extract used in the present invention was purchased from a raw material company called BASF, apple stem cells from a raw material company called Mibelle, and argan oil was purchased from a Moroccan company.

ingredient Comparative Example 1 (Unit: wt%) Example 1 (unit: wt%) Distilled water To 100 To 100 glycerin 1.0 1.0 Butylene Glycol 2.0 2.0 Dipropylene glycol 3.0 3.0 Hibiscus seed extract - 1.0 Apple stem cells - 3.0 Argan oil - 1.0 Polyglyceryl-3 Methylglucose Distearate 0.5 0.5 Cetyl 2-ethyl hexanoate 4.0 4.0 Meadowfoam seed oil 3.0 3.0 Cetostearyl alcohol 3.0 3.0 Methylparaben 0.2 0.2 Propylparaben 0.1 0.1 Hydroxyethyl acrylate. Sodium Acryloyldimethyl Taurate Copolymer 0.8 0.8

Thirty Korean women in their 30s and 50s were divided into the above two groups for a period of 6 weeks, and the cosmetic composition prepared in Examples and Comparative Examples was used twice a day to compare skin conditions by the following evaluation items. It was.

Evaluation items included corneometer moisturizing power, keratin condition and angular mass measurement using D-squame black tape, skin roughness and wrinkle measurement using PRISMO, skin density measurement using Dermascan C, skin gloss measurement using Sebumeter, Chromameter Subjective evaluation by skin brightness measurement and questionnaire.

[Test Example 1] Moisturizing power measurement

Moisturizing power, that is, the amount of moisture change, was measured before and after application of the composition of the embodiment of the present invention using a corneometer at 2, 4, and 6 weeks after application, and the results are shown in FIG. 1. It was.

As can be seen in Figure 1, after 6 weeks of applying the composition of the embodiment according to the present invention showed a skin moisture improvement of about 31%, it was possible to recover from the dry and dry skin to moist and smooth skin. On the other hand, compared to the case of the comparative example, the moisturizing power was reduced to 30% or less.

Test Example 2 Keratin state and angular mass measurement

Keratin and angular mass of the skin was measured before and after the start of the application of the composition of the embodiment according to the invention using the D-squame black tape and at 2, 4, 6 weeks after the application, the results are shown in Figure 2 It was.

As can be seen in FIG. 2, after 6 weeks of application of the composition of the embodiment according to the invention the angular mass of about 21% was reduced.

In addition, Figure 3 is a microscopic image showing the skin keratin state, it can be confirmed that the skin keratin state is improved to produce a smooth and smooth skin. On the other hand, in the comparative example, keratin was maintained as it was and the angular mass was large, showing a rough skin surface.

Test Example 3 Skin Gloss Measurement

Skin glossiness was measured before and after application of the composition of the embodiment of the present invention using the Seubumeter, 2 weeks, 4 weeks, 6 weeks after the application, the results are shown in FIG.

As can be seen in FIG. 4, skin shine increased by about 32% after 6 weeks of application of the compositions of the examples according to the invention.

In addition, the effect of improving the luster by age of the composition is shown in FIG. The skin gloss of 47 years old (mean age) at the time of not applying the composition of the embodiment according to the present invention is only about 78% of the skin gloss of 35 years old (mean age), but the same level at 6 weeks of applying the composition Increased to 12 years younger skin radiance than the original age. On the other hand, in the comparative example, about 6% of skin gloss increased after 6 weeks of applying the composition of the comparative example.

Test Example 4 Skin Roughness and Wrinkle Measurement

Skin roughness was measured before and after the start of the application of the composition of the embodiment according to the present invention and two weeks, four weeks, six weeks after the application using the PRISMO, the results are shown in Figures 6 and 7.

As can be seen in Figures 6 and 7, the composition of the embodiment according to the present invention showed a marked improvement in skin roughness and wrinkles after 6 weeks of application.

In addition, Figure 8 is a three-dimensional image of the skin roughness and wrinkles by using the PRISMO, after 6 weeks of use of the composition according to the invention the wrinkles become lighter than before, it can be seen that the skin roughness is much improved. On the other hand, in the case of the comparative example, there was no significant difference after 6 weeks and before application of the composition of the comparative example.

Test Example 5 Measurement of Skin Density

Skin density was measured before and after application of the composition of the embodiment of the present invention using the Dermascan C, 2 weeks, 4 weeks, 6 weeks after the application, the results are shown in FIG.

As can be seen in Figure 9, the composition of the embodiment according to the present invention showed a significant skin density improvement effect after 6 weeks of use as the skin density gradually increased.

In addition, Fig. 10 shows the results of the measurement of the skin density by age group, the skin density of 47 years (average age) after 4 weeks of use of the composition of the present invention is 35 years (average age) of not using the composition or used for 2 weeks It can be seen that the skin density is improved.

Figure 11 is a Dermascan image showing the change in skin density, showing that the skin density gradually increases with the period of use of the composition of the present invention. On the other hand, in the comparative example, there was no difference in skin density when comparing the composition 6 weeks after the application and before the application.

Test Example 6 Skin Brightness Measurement

Skin brightness improvement was measured before and after the start of the application of the composition of the embodiment according to the present invention using Chromameter 2 weeks, 4 weeks, 6 weeks after the application, the results are shown in Figure 12.

As can be seen in Figure 12, the composition of the embodiment according to the present invention showed an excellent skin brightness improvement effect after 6 weeks of use.

In addition, FIG. 13 shows the results of skin brightness measurement by age group, and after 6 weeks of using the composition of the present invention, the skin brightness of 47 years old (mean age) was improved to 35 years old (mean age). On the other hand, in the comparative example, compared with 6 weeks after the application of the composition and before the application was not effective in improving the skin brightness.

[Test Example 7] Subjective efficacy evaluation

At the end of Test Examples 1 to 6, subjects were tested for the composition of Examples and Comparative Examples, and subjective efficacy evaluations were performed. The results of the satisfaction are shown in Table 2 below.

Skin improvement effect Feeling Total satisfaction lubricity Skin tone improvement Increased skin radiance Absorbance Application Good makeup Example 90% 63% 77% 88% 70% 93% 90% Comparative example 60% 21% 33% 80% 65% 70% 55%

1 is a graph showing the results of measuring the skin moisture after application of the cosmetic composition according to the present invention.

2 is a graph showing the results of measuring the angular mass after application of the cosmetic composition according to the present invention.

Figure 3 is a keratin microscope image using a D-squame black tape showing the skin keratin state before and after the application of the cosmetic composition according to the present invention.

Figure 4 is a graph showing the result of measuring the skin gloss after application of the cosmetic composition according to the present invention.

Figure 5 is a graph showing the results of analysis by age group of skin luster improvement after application of the cosmetic composition according to the present invention.

Figure 6 is a graph showing the result of measuring the skin roughness after the application of the cosmetic composition according to the present invention.

Figure 7 is a graph showing the result of measuring the skin wrinkles after the application of the cosmetic composition according to the present invention.

8 is a three-dimensional image of the skin roughness and wrinkles by using the PRISMO after the application of the cosmetic composition according to the present invention.

9 is a graph showing the results of measuring skin density after application of the cosmetic composition according to the present invention.

10 is a graph showing the results of analysis by age group of skin density improvement after application of the cosmetic composition according to the present invention.

11 is a Dermascan image showing the skin density change after the application of the cosmetic composition according to the present invention.

12 is a graph showing the results of measuring skin brightness after application of the cosmetic composition according to the present invention.

Figure 13 is a graph showing the results of analysis by age group of skin brightness improvement after the application of the cosmetic composition according to the present invention.

Claims (8)

A skin composition for preventing skin aging, comprising apple stem cells, hibiscus seed extract and argan oil as active ingredients. The cosmetic composition for preventing skin aging according to claim 1, wherein the apple stem cells are contained in an amount of 1.0% by weight to 3.0% by weight based on the total weight of the composition. The cosmetic composition for preventing skin aging according to claim 1, wherein the hibiscus seed extract is contained in an amount of 0.5% to 1.0% by weight based on the total weight of the composition. The cosmetic composition for preventing skin aging according to claim 1, wherein the argan oil is contained in an amount of 0.5% to 1.0% by weight based on the total weight of the composition. The method of claim 1, wherein the composition further comprises one or more selected from the group consisting of oat seed extract, hyaluronic acid, chitosan, soybean extract, polyglyceryl-8 stearate, ceramide, phytosphingosine and yeast extract Skin anti-aging cosmetic composition characterized in. Apple stem cells, hibiscus seed extract and argan oil comprising a cosmetic composition for enhancing skin moisture, characterized in that it contains as an active ingredient. Apple stem cells, hibiscus seed extract and cosmetic composition for skin keratin reduction or skin keratin condition improvement comprising an argan oil as an active ingredient. Cosmetic composition for increasing skin gloss or reducing skin roughness, comprising apple stem cells, hibiscus seed extract and argan oil as active ingredients.

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