KR20210017400A - Cosmetic composition comprising nanoemulsion containing bakuchiol as active ingredient - Google Patents

Abstract

The present invention relates to a cosmetic composition for skin moisturizing or improving skin elasticity, comprising a nanoemulsion containing bakuchiol as an active ingredient. In the present invention, the nanoemulsion containing bakuchiol is contained in an amount of 0.1 to 30.0 wt% based on the total weight of the cosmetic composition. According to the present invention, the nanoemulsion containing bakuchiol can provide various functional cosmetics by improving skin elasticity and moisturizing the skin.

Description

A cosmetic composition containing a nanoemulsion containing bakuchiol as an active ingredient {COSMETIC COMPOSITION COMPRISING NANOEMULSION CONTAINING BAKUCHIOL AS ACTIVE INGREDIENT}

It relates to a cosmetic composition for skin moisturizing or skin elasticity improvement comprising a nanoemulsion containing bakuchiol as an active ingredient.

Human skin undergoes various physical and chemical changes during the aging process. The causes are largely classified into intrinsic aging and photo-aging, and research on this has been actively conducted. UV rays, stress, disease conditions, environmental factors, wounds, and aging can be caused by activating free radicals.If such a condition intensifies, it destroys the antioxidant defenses existing in the living body and damages cells and tissues, leading to adult diseases. And promotes aging.

More specifically, skin cells and tissues are destroyed by oxidation of lipids, proteins, polysaccharides, and nucleic acids, which are major components of the skin, resulting in skin aging. Particularly, protein oxidation is severe in the skin's connective tissues, such as collagen, hyaluronic acid, elastin, proteoglycan, fibronectin, etc. If this gets worse, mutations in DNA lead to mutations, cancer, and immune function decline.

Therefore, free radicals generated during the body's metabolic process, UV irradiation, and free radicals mediated by inflammatory reactions are eliminated to protect the cell membrane, and cells that have already been damaged must be regenerated by active metabolism to proliferate the skin. Can recover quickly and maintain healthy skin.

Various natural ingredients and substances are used in cosmetic compositions to improve skin moisture and elasticity.

Korean Patent Publication No. 2010-0066754 discloses a skin moisturizing cosmetic composition prepared by fermenting a mixture of herbal materials consisting of Machihyeon, Maekmundong, Bogolji, Saengjihwang, Yeochunho, Yeonjayuk, Jisil, Cheongung, Cheonmundong, and soil.

An object of the present invention is to provide a cosmetic composition comprising a nanoemulsion containing bakuchiol having excellent skin moisturizing effect and skin elasticity improvement effect.

The above object is achieved by a cosmetic composition for skin moisturizing comprising a nanoemulsion containing bakuchiol as an active ingredient, and a cosmetic composition for improving skin elasticity comprising a nanoemulsion containing bakuchiol as an active ingredient.

The nanoemulsion containing bakuchiol comprises 0.5 to 20.0% by weight of phospholipid, 0.1 to 10% by weight of bakuchiol, 0.1 to 10% by weight of antioxidant and 0.1 to 20% by weight of oil based on the total weight of the nanoemulsion. Oily part; And an aqueous phase including 30 to 70.0% by weight of polyol and the remaining amount of purified water.

The nanoemulsion containing bakuchiol may be contained in an amount of 0.1 to 30.0% by weight based on the total weight of the cosmetic composition.

The cosmetic composition comprising a nanoemulsion containing bakuchiol according to the present invention exhibits skin moisturizing power, skin barrier enhancement, skin elasticity improvement effect, and skin irritation relief.

All technical terms used in the present invention, unless otherwise defined, have the following definitions and correspond to the meanings as commonly understood by one of ordinary skill in the relevant fields of the present invention. In addition, although preferred methods or samples are described in the present specification, those similar or equivalent are included in the scope of the present invention.

The term “about” refers to 30, 25, 20, 15, 10, 9, 8, 7, 6, 5, or 30, 25, 20, 15, 10, 9, 8, 7, 6, 5, or relative to a reference amount, level, value, number, frequency, percentage, dimension, size, amount, weight or length. It means an amount, level, value, number, frequency, percentage, dimension, size, amount, weight or length varying by 4, 3, 2 or 1%.

Throughout this specification, unless otherwise required by the context, the terms “comprise” and “comprising” include the steps or components presented, or groups of steps or components, but any other step or component, or It is to be understood that a step or group of components is not excluded.

The present invention provides a cosmetic composition comprising a nanoemulsion containing bakuchiol. The nanoemulsion is a nanoemulsion formed by mixing an oil phase containing bakuchiol, phospholipids, oils and antioxidants, and an aqueous phase containing polyol and purified water. The nanoemulsion according to the present invention is characterized in that it does not contain a monohydric alcohol.

In the present invention, the term'nanoemulsion' refers to a liquid in which one of two or more liquids that do not dissolve with each other is dispersed in the form of small particles on the other side, and the size of the particles is a nano-scale.

According to an embodiment of the present invention, the nanoemulsion containing bakuchiol is 0.5 to 20.0% by weight of phospholipid, 0.1 to 10% by weight of bakuchiol, 0.1 to 10% by weight of antioxidant and 0.1 based on the total weight of the nanoemulsion. Oil phase portion containing oil of 20% by weight; And an aqueous phase comprising 30 to 70.0% by weight of polyol and the remaining amount of purified water.

The polyol used in the nanoemulsion of the present invention is not particularly limited, but preferably propylene glycol, dipropylene glycol, 1,3-butylene glycol, glycerin, methylpropanediol, isforene glycol, pentylene glycol, erythritol, and xylitol , At least one selected from the group consisting of sorbitol and mixtures thereof. Preferably, it is selected from the group consisting of propylene glycol, 1,3-butylene glycol, glycerin and mixtures thereof, and most preferably glycerin. The polyol may be included in an amount of 30 to 70% by weight based on the total weight of the nanoemulsion.

The oily part of the nanoemulsion of the present invention is composed of bakuchiol, phospholipids, oils and antioxidants.

Bakuchiol used in the nanoemulsion of the present invention is a compound (meroterpene) having a terpenophenol-based terpenoid structure and has the following formula.

[Formula 1]

Bakuchiol is a substance isolated from the seeds of a plant called bakuchi ( Psoralea corylifolia ), which is used as a medicinal herb in India and China, and is P. grandulosa , P. drupaceae, Ulmus davidiana , Otholobium pubescens , Piper longum , and Aerva sangulnolenta Blum. It is also known to be isolated from such plants. Bakuchiol was first known to have been synthesized in 1973 (Damodaran, NP; Dev, Sukh (January 1973). "Meroterpenoids-III". Tetrahedron . 29 (9): 1209-1213.), Cytenol A (Sytenol®) A, Sytheon Ltd.). Bakuchiol is known for its antioxidant, anti-inflammatory, and antibacterial effects. In the present invention, bakuchiol extracted from Bogolji and separated or synthetic bakuchiol may be used.

The present invention is characterized in that bakuchiol is included in a nanoemulsion and used in a cosmetic composition. Bakuchiol is preferably contained in an amount of 0.1 to 10.0% by weight based on the total weight of the nanoemulsion. Bakuchiol is well absorbed into the skin through nanoemulsification, and has excellent skin moisturizing effect and skin elasticity improvement effect compared to the case without nanoemulsification, and has little skin irritation.

In the present invention, the antioxidant may be tocopherol, a tocopherol derivative (eg, tocopyryl acetate), or a mixture thereof. The antioxidant is preferably contained in an amount of 0.1 to 10.0% by weight based on the total weight of the nanoemulsion.

The oils of the nanoemulsion of the present invention include hydrocarbon oils such as hexadecane and paraffin oil, synthetic ester oils, silicone oils such as dimethicone and cyclomethicone, vegetable oils such as sunflower oil, corn oil and soybean oil, and blood. It may contain at least one selected from the group consisting of sphingoid lipids and ceramides such as tosphingosine, sphingosine and spingganine. The amount of oil used is preferably contained in an amount of 0.1 to 20.0% by weight.

Phospholipids used in the nanoemulsion of the present invention are used as amphiphilic lipids, and include natural phospholipids (e.g. egg yolk lecithin or soybean lecithin) and synthetic phospholipids (e.g. dipalmitoylpostatidylcholine or hydrogenated lecithin), Preferably it is lecithin. More preferably, the lecithin is naturally derived unsaturated lecithin or saturated lecithin extracted from soybean or egg yolk. Typically, the amount of phosphatidyl choline is 23-95%, and the amount of phosphadidylethanolamine is 20% or less in the naturally derived lecithin. In the nanoemulsion of the present invention, the amount of lecithin used is 0.5 to 20.0% by weight, more preferably 1.0 to 10.0% by weight, based on the total weight of the nanoemulsion.

Purified water used in the nanoemulsion of the present invention is generally deionized distilled water, and its amount is 1.0 to 50.0% by weight based on the total weight of the nanoemulsion.

The nanoemulsion may be prepared through various methods known in the art, but is preferably prepared by applying a mixture containing the above components to a high pressure homogenizer. The preparation of nanoemulsion by a high-pressure homogenizer can be carried out under various conditions (e.g., pressure, number of times, etc.) depending on the desired particle size, preferably 1 to 5 times under a pressure of 600 to 1,200 bar. To prepare a nanoemulsion.

Hereinafter, the present invention will be described in more detail through examples. These examples are only for describing the present invention in more detail, and it will be apparent to those of ordinary skill in the art that the scope of the present invention is not limited by these examples according to the gist of the present invention. .

Manufacturing example 1 and Comparative Production Example One: Bakuchiol contain Nano emulsion Produce

division ingredient Manufacturing Example 1 Comparative Production Example 1 A Purified water To 100 To 100 glycerin 65.0 65.0 B lecithin 2.00 2.00 Bakuchiol 5.00 - Dimethicone 5.00 5.00 Tocopherol 1.00 1.00

The phases A and B were heated and mixed to 75°C, respectively, and then uniformly stirred. Then, the mixture was passed through a high-pressure homogenizer three times under conditions of 1,000 bar and then cooled to prepare a nanoemulsion having a particle size of about 50 nm.

Formulation example : Bakuchiol contain Nanoemulsion Included Cosmetic Preparation of the composition

Using the nanoemulsion-containing cosmetic composition of Preparation Example 1 of Table 1, a cream having the composition shown in Table 2 was prepared. Nanoemulsion containing bakuchiol was prepared in Example 1, which is a cosmetic containing, and Comparative Example 1 containing bakuchiol was prepared for comparison of efficacy, Comparative Example 2 not containing both, and bakuchiol was not included. Comparative Example 3 was prepared, which is a cosmetic composition containing a non-woven nanoemulsion (Comparative Preparation Example 1).

division ingredient Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 A Purified water To 100 To 100 To 100 To 100 glycerin 10.0 10.0 10.0 10.0 Butylene Glycol 5.00 5.00 5.00 5.00 Carbomer 0.30 0.30 0.30 0.30 B Polyglyceryl-3methylglucose distearate 1.70 1.70 1.70 1.70 Cetyl alcohol 2.50 2.50 2.50 2.50 Dimethicone 1.00 1.00 1.00 1.00 Shea Butter 1.50 1.50 1.50 1.50 Caprylic/Capric Triglyceride 4.00 4.00 4.00 4.00 Bakuchiol - 0.50 - - C Tromethamine 0.25 0.25 0.25 0.25 antiseptic 0.50 0.50 0.50 0.50 Preparation Example 1 Nanoemulsion 10.00 - - - Nanoemulsion of Comparative Preparation Example 1 - - - 10.00

Experimental example 1: moisturizing effect

The clinical moisturizing effect of the cosmetic compositions of Example 1 and Comparative Examples 1 to 3 was measured as follows. Through a questionnaire survey, 100 healthy adult men and women who feel dry skin were randomly divided into four groups (A, B, C, and D) of 25 people, and then the cosmetic composition of Example 1 was compared to group A and group B. The cosmetic composition of Example 1, the cosmetic composition of Comparative Example 2 to the C group, and the cosmetic composition of Comparative Example 3 to the D group were applied to the face twice a day for 2 weeks. The moisturizing effect was evaluated every 1 week from the start of the actual use test, and the improvement effect after the end of the test using Corneometer CM 820 (Corage +Khazaka, Germany). The experimental results are shown in Table 3 below.

division Before use 2 weeks after use 4 weeks after use Example 1 21.4 35.6 45.7 Comparative Example 1 23.7 29.4 35.9 Comparative Example 2 23.8 27.7 30.5 Comparative Example 3 23.2 28.2 32.1

As shown in Table 3, it was confirmed that the cosmetic composition of Example 1 containing the bakuchiol-containing nanoemulsion as an active ingredient has excellent moisturizing effect compared to the cosmetic compositions of Comparative Examples 1 to 3.

Experimental example 2: Skin elasticity improvement effect

In this Experimental Example 2, in order to examine the effect of improving skin elasticity of the cosmetic compositions according to Examples and Comparative Examples, 40 women in their 30s to 40s with decreased elasticity were measured. After dividing into 4 groups of 10 people, Example 1 in Group 1, Comparative Example 1 in Group 2, Comparative Example 2 in Group 3, and Comparative Example 3 in Group 4, twice each morning and evening on the face 12 After weekly application, skin elasticity was measured after 12 weeks. The elasticity of the facial area was measured using a cutometer SEM575 (MPA 580, Courage+Khazaka GmbH, Germany), and R2 (biological elasticity), which represents skin elasticity, was measured before and after application, and then evaluated as a degree of improvement (%). . The results are shown in Table 4 below, and the results are an average of the degree of improvement for each group.

division Skin elasticity improvement (%) Example 1 23.5 Comparative Example 1 16.2 Comparative Example 2 10.2 Comparative Example 3 11.3

As shown in Table 4, it was found that the cosmetic composition of Example 1 containing bakuchiol-containing nanoemulsion as an active ingredient significantly improved skin elasticity compared to the cosmetic compositions of Comparative Examples 1 to 3.

Experimental example 3: human skin Patch exam

In order to investigate the objective irritation of the primary irritation on the skin, 20 subjects with healthy skin under the age of 20-50 were tested. After dropping the product into the patch chamber by 20ul each, volatile substances were volatilized for 1 hour, and then the patch was attached to the subject, and the patch was removed after 24 hours, and the reading was performed after 30 minutes. The results are shown in Table 5.

division Patch test Example 1 No irritation 0.00 Comparative Example 1 Non-irritating 3 0.41 Comparative Example 2 Unstimulated 1 0.13 Comparative Example 3 Unstimulated 1 0.13

As a result of the test for the primary skin irritation, in Comparative Example 1, 0.41 of non-irritation 3 was observed, but in Example 1, no irritation was observed. From this, it was confirmed that the cosmetic composition of Example 1 gave less irritation to the skin.

As described above, specific parts of the present invention have been described in detail, and it is obvious that these specific techniques are only preferred embodiments for those of ordinary skill in the art, and the scope of the present invention is not limited thereto. Therefore, it will be said that the practical scope of the present invention is defined by the appended claims and their equivalents.

Claims (4)

Skin moisturizing cosmetic composition comprising a nanoemulsion containing bakuchiol as an active ingredient. A cosmetic composition for improving skin elasticity comprising a nanoemulsion containing bakuchiol as an active ingredient. The method of claim 1 or 2, wherein the nanoemulsion containing bakuchiol is 0.5 to 20.0% by weight of phospholipid, 0.1 to 10% by weight of bakuchiol, 0.1 to 10% by weight of antioxidant and Oil phase containing 0.1 to 20% by weight of oil; And 30 to 70.0% by weight of the polyol and the water phase comprising the remaining amount of purified water; characterized in that it comprises a cosmetic composition. The cosmetic composition according to claim 1 or 2, wherein the nanoemulsion containing bakuchiol is contained in an amount of 0.1 to 30.0% by weight based on the total weight of the cosmetic composition.