KR102286990B1 - Cosmetic composition comprising nanoemulsion containing bakuchiol as active ingredient - Google Patents

Abstract

It relates to a cosmetic composition for skin moisturizing or improving skin elasticity comprising a nanoemulsion containing bakuchiol as an active ingredient. Nanoemulsion containing bakuchiol in the present invention is characterized in that it is contained in an amount of 0.1 to 30.0% by weight based on the total weight of the cosmetic composition. According to the present invention, the nanoemulsion containing bakuchiol has the effect of improving skin elasticity and moisturizing the skin, so that various functional cosmetics can be provided.

Description

Cosmetic composition comprising a nanoemulsion containing bakuchiol as an active ingredient {COSMETIC COMPOSITION COMPRISING NANOEMULSION CONTAINING BAKUCHIOL AS ACTIVE INGREDIENT}

It relates to a cosmetic composition for skin moisturizing or improving skin elasticity comprising a nanoemulsion containing bakuchiol as an active ingredient.

Human skin undergoes various physical and chemical changes during the aging process. The causes are largely divided into intrinsic aging and photo-aging, and studies on these have been actively conducted. Free radicals are activated and caused by UV rays, stress, disease states, environmental factors, wounds, and aging. and accelerate aging.

More specifically, lipids, proteins, polysaccharides and nucleic acids, which are major constituents of the skin, are oxidized to destroy skin cells and tissues, and eventually skin aging occurs. In particular, the oxidation of proteins cuts the connective tissues of the skin, such as collagen, hyaluronic acid, elastin, proteoglycan, and fibronectin, causing severe hyperinflammatory reactions and disruption of skin elasticity. And if it gets worse, it leads to mutations, cancer induction, and decreased immune function due to DNA mutations.

Therefore, it is necessary to protect the cell membrane by eliminating free radicals generated during the body's metabolic process, UV irradiation, and free radicals mediated by inflammatory reactions, and to regenerate damaged cells through active metabolism to proliferate the cells. can recover quickly and maintain healthy skin.

Various natural ingredients and substances are used in cosmetic compositions to improve skin moisture and elasticity.

Korean Patent Application Laid-Open No. 2010-0066754 discloses a cosmetic composition for moisturizing the skin prepared by fermenting a mixture of herbal medicines consisting of Machihyeon, Maekmundong, Bogolji, Saengjihwang, Yeochunho, Yeonjayuk, Jisil, Cheongung, Cheonmundong and Tosaja.

An object of the present invention is to provide a cosmetic composition comprising a nanoemulsion containing bakuchiol having excellent skin moisturizing effect and skin elasticity improvement effect.

The above object is achieved by a cosmetic composition for skin moisturizing comprising a nanoemulsion comprising bakuchiol as an active ingredient, and a cosmetic composition for improving skin elasticity comprising a nanoemulsion comprising bakuchiol as an active ingredient.

The nanoemulsion containing bakuchiol contains 0.5 to 20.0% by weight of phospholipids, 0.1 to 10% by weight of bakuchiol, 0.1 to 10% by weight of antioxidant, and 0.1 to 20% by weight of oil, based on the total weight of the nanoemulsion. Masturbation; and an aqueous phase comprising 30 to 70.0% by weight of polyol and the remainder of purified water.

The nanoemulsion containing bakuchiol may be contained in an amount of 0.1 to 30.0% by weight based on the total weight of the cosmetic composition.

The cosmetic composition comprising the nanoemulsion containing bakuchiol according to the present invention exhibits an effect of strengthening skin moisturizing power, strengthening skin barrier, improving skin elasticity, and alleviating skin irritation.

All technical terms used in the present invention, unless otherwise defined, have the following definitions and have the meanings as commonly understood by one of ordinary skill in the art of the present invention. In addition, although preferred methods and samples are described herein, similar or equivalent ones are also included in the scope of the present invention.

The term "about" means 30, 25, 20, 15, 10, 9, 8, 7, 6, 5, means an amount, level, value, number, frequency, percentage, dimension, size, amount, weight or length varying by 4, 3, 2 or 1%.

Throughout this specification, unless the context requires otherwise, the terms "comprises" and "comprising" include the steps or components presented, or groups of steps or components, but include any other step or component, or It is to be understood as implying that a step or group of elements is not excluded.

The present invention provides a cosmetic composition comprising a nanoemulsion containing bakuchiol. The nanoemulsion is a nanoemulsion formed by mixing an oil phase containing bakuchiol, phospholipids, oil and antioxidants, and an aqueous phase containing polyol and purified water. The nanoemulsion according to the present invention is characterized in that it does not contain a monohydric alcohol.

In the present invention, 'nanoemulsion' refers to a liquid in which one of two or more liquids that do not dissolve in each other is dispersed in the form of small particles in the other, and the size of the particles is nano-unit size.

According to an embodiment of the present invention, the nanoemulsion comprising bakuchiol is 0.5 to 20.0 wt% of phospholipid, 0.1 to 10 wt% of bakuchiol, 0.1 to 10 wt% of antioxidant and 0.1 to the total weight of the nanoemulsion to 20% by weight of oil containing oil; and an aqueous phase comprising 30 to 70.0% by weight of polyol and the remainder of purified water.

The polyol used in the nanoemulsion of the present invention is not particularly limited, but preferably propylene glycol, dipropylene glycol, 1,3-butylene glycol, glycerin, methylpropanediol, isporene glycol, pentylene glycol, erythritol, xylitol , at least one selected from the group consisting of sorbitol and mixtures thereof. Preferably, it is selected from the group consisting of propylene glycol, 1,3-butylene glycol, glycerin and mixtures thereof, and most preferably glycerin. The polyol may be included in an amount of 30 to 70% by weight based on the total weight of the nanoemulsion.

The oil phase of the nanoemulsion of the present invention is composed of bakuchiol, phospholipids, oil and antioxidants.

Bakuchiol used in the nanoemulsion of the present invention is a compound (meroterpene) having a terpenophenol-based terpenoid structure, and has the following chemical formula.

[Formula 1]

Bakuchiol is a substance isolated from the seeds of a plant called bogolji (bakuchi, Psoralea corylifolia ) that is used as a herbal medicine in India or China , P. grandulosa , P. drupaceae, Ulmus davidiana , Otholobium pubescens , Piper longum , and Aerva sangulnolenta Blum. It is also known to be isolated from plants such as Bakuchiol was first known to have been synthesized in 1973 (Dmodaran, NP; Dev, Sukh (January 1973). "Meroterpenoids-III". Tetrahedron . 29 (9): 1209-1213.), Cytenol A (Sytenol® A, Sytheon Ltd.) is sold under the trade name. Bakuchiol is known for its antioxidant, anti-inflammatory, and antibacterial effects. In the present invention, bakuchiol extracted from bogolji and separated or synthetic bakuchiol may be used.

The present invention is characterized in that bakuchiol is included in a nanoemulsion and used in a cosmetic composition. Bakuchiol is preferably included in an amount of 0.1 to 10.0% by weight based on the total weight of the nanoemulsion. Through nano-emulsification, bakuchiol is well absorbed into the skin, and compared to the case without nano-emulsification, it has excellent skin moisturizing effect and skin elasticity improvement effect and almost no skin irritation.

In the present invention, the antioxidant may be tocopherol, a tocopherol derivative (eg, tocopyryl acetate) or a mixture thereof. The antioxidant is preferably included in an amount of 0.1 to 10.0% by weight based on the total weight of the nanoemulsion.

The oil of the nanoemulsion of the present invention is a hydrocarbon-based oil such as hexadecane and paraffin oil, an ester-based synthetic oil, a silicone oil such as dimethicone and cyclomethicone, vegetable oil such as sunflower oil, corn oil and soybean oil, blood It may include at least one selected from the group consisting of sphingonoid lipids and ceramides such as tosphingosine, sphingosine and sphinganine. The oil is preferably used in an amount of 0.1 to 20.0% by weight.

Phospholipids used in the nanoemulsion of the present invention are used as amphiphilic lipids, and include natural phospholipids (eg, egg yolk lecithin or soybean lecithin) and synthetic phospholipids (eg, dipalmitoylpostatidylcholine or hydrogenated lecithin), Preferably it is lecithin. More preferably, the lecithin is naturally-derived unsaturated lecithin or saturated lecithin extracted from soybean or egg yolk. In general, naturally occurring lecithin has an amount of phosphatidyl choline of 23-95%, and an amount of phosphatidylethanolamine of 20% or less. The amount of lecithin used in the nanoemulsion of the present invention is 0.5 to 20.0 wt%, more preferably 1.0 to 10.0 wt%, based on the total weight of the nanoemulsion.

Purified water used in the nanoemulsion of the present invention is generally deionized distilled water, and the amount used is 1.0-50.0 wt% based on the total weight of the nanoemulsion.

The preparation of the nanoemulsion can be made through various methods known in the art, but is preferably prepared by applying a mixture including the above components to a high-pressure homogenizer. The preparation of the nanoemulsion by the high-pressure homogenizer can be carried out under various conditions (eg, pressure, number of times, etc.) according to the desired particle size, preferably 1 to 5 times under a pressure of 600 to 1,200 bar. to pass through to prepare a nanoemulsion.

Hereinafter, the present invention will be described in more detail through examples. These examples are only for illustrating the present invention in more detail, and it will be apparent to those skilled in the art that the scope of the present invention is not limited by these examples according to the gist of the present invention. .

manufacturing example 1 and Comparative Preparation Example One: bakuchiol contain Nanoemulsion manufacturing

division ingredient Preparation Example 1 Comparative Preparation Example 1 A Purified water To 100 To 100 glycerin 65.0 65.0 B lecithin 2.00 2.00 bakuchiol 5.00 - dimethicone 5.00 5.00 tocopherol 1.00 1.00

Phase A and phase B were heated and mixed to 75° C., respectively, and then uniformly stirred. Then, the mixture was passed through a high-pressure homogenizer three times under the condition of 1,000 bar and then cooled to prepare a nanoemulsion having a particle size of about 50 nm.

Formulation example : bakuchiol contain nano emulsion. containing cosmetics Preparation of the composition

Using the nanoemulsion-containing cosmetic composition of Preparation Example 1 of Table 1, a cream having the composition shown in Table 2 was prepared. Example 1, which is a cosmetic containing nanoemulsion containing bakuchiol, was prepared, and Comparative Example 1 containing bakuchiol was prepared for efficacy comparison, Comparative Example 2 which did not contain both, and bakuchiol was not included Comparative Example 3, which is a cosmetic composition containing a nano-emulsion (Comparative Preparation Example 1), was prepared.

division ingredient Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 A Purified water To 100 To 100 To 100 To 100 glycerin 10.0 10.0 10.0 10.0 Butylene Glycol 5.00 5.00 5.00 5.00 Carbomer 0.30 0.30 0.30 0.30 B Polyglyceryl-3 methylglucose distearate 1.70 1.70 1.70 1.70 cetyl alcohol 2.50 2.50 2.50 2.50 dimethicone 1.00 1.00 1.00 1.00 shea butter 1.50 1.50 1.50 1.50 Caprylic/Capric Triglycerides 4.00 4.00 4.00 4.00 bakuchiol - 0.50 - - C tromethamine 0.25 0.25 0.25 0.25 antiseptic 0.50 0.50 0.50 0.50 Preparation Example 1 Nanoemulsion 10.00 - - - Nanoemulsion of Comparative Preparation Example 1 - - - 10.00

Experimental example 1: Moisturizing effect

The clinical moisturizing effect of the cosmetic compositions of Example 1 and Comparative Examples 1 to 3 was measured as follows. Through a survey, 100 healthy adult men and women who felt that their skin was dry were randomly divided into 4 groups (A, B, C and D) of 25 people each, and then the cosmetic composition of Example 1 was compared to group A and the cosmetic composition of Example 1 was compared to group B. The cosmetic composition of Example 1, the cosmetic composition of Comparative Example 2 to group C, and the cosmetic composition of Comparative Example 3 to group D were applied to the face twice a day for 2 weeks, respectively. The moisturizing effect was evaluated using Corneometer CM 820 (Corage +Khazaka, Germany) for every 1 week from the start of the actual use test, and the improvement effect after the end. The experimental results are shown in Table 3 below.

division before use 2 weeks after use 4 weeks after use Example 1 21.4 35.6 45.7 Comparative Example 1 23.7 29.4 35.9 Comparative Example 2 23.8 27.7 30.5 Comparative Example 3 23.2 28.2 32.1

As shown in Table 3, it was confirmed that the cosmetic composition of Example 1 containing the bakuchiol-containing nanoemulsion as an active ingredient had an excellent moisturizing effect compared to the cosmetic compositions of Comparative Examples 1 to 3.

Experimental example 2: Skin elasticity improvement effect

In this Experimental Example 2, in order to examine the skin elasticity improvement effect of the cosmetic compositions according to Examples and Comparative Examples, 40 women in their 30s and 40s with decreased elasticity were measured. After dividing into 4 groups of 10 people, 1 group received Example 1, group 2 received Comparative Example 1, group 3 received Comparative Example 2, and group 4 had Comparative Example 3 applied to the face twice daily in the morning and in the evening 12 times. After a weekly application, skin elasticity was measured after 12 weeks. The elasticity of the face was measured using a cutometer SEM575 (MPA 580, Courage+Khazaka GmbH, Germany), and R2 (biological elasticity), which indicates skin elasticity, was measured before and after application, and the improvement (%) was evaluated. . The results are shown in Table 4 below, and the results are the average values of the degree of improvement for each group.

division Skin elasticity improvement (%) Example 1 23.5 Comparative Example 1 16.2 Comparative Example 2 10.2 Comparative Example 3 11.3

As shown in Table 4, it was found that the cosmetic composition of Example 1 containing the bakuchiol-containing nanoemulsion as an active ingredient significantly improved skin elasticity compared to the cosmetic compositions of Comparative Examples 1 to 3.

Experimental example 3: human skin patch test

In order to investigate the objective stimulation of the primary irritation appearing on the skin, 20 subjects with healthy skin aged 20-50 years were tested. After dropping 20ul of the product into the patching chamber, volatile substances were volatilized for 1 hour, the patch was attached to the subject's back, and the patch was removed after 24 hours, and reading was performed after 30 minutes. The results are shown in Table 5.

division patch test Example 1 no irritation 0.00 Comparative Example 1 Unstimulated 3 0.41 Comparative Example 2 Unstimulated 1 0.13 Comparative Example 3 Unstimulated 1 0.13

As a result of the test on the primary skin irritation, in Comparative Example 1, non-irritation 3 of 0.41 was observed, but in Example 1, no-irritation was observed. From this, it was confirmed that the cosmetic composition of Example 1 gave less irritation to the skin.

As described above in detail a specific part of the present invention, for those of ordinary skill in the art, this specific description is only a preferred embodiment, and it is clear that the scope of the present invention is not limited thereto. Accordingly, the substantial scope of the present invention will be defined by the appended claims and their equivalents.

Claims (4)

Nanoemulsion containing bakuchiol as an active ingredient,
The nanoemulsion containing bakuchiol contains 1.0 to 10.0% by weight of lecithin, 0.1 to 10% by weight of bakuchiol, 0.1 to 10% by weight of antioxidant, and 0.1 to 20% by weight of oil, based on the total weight of the nanoemulsion. Masturbation; and an aqueous phase comprising 30 to 70.0% by weight of polyol and the remaining amount of purified water;
The nanoemulsion is a cosmetic composition for skin moisturizing, characterized in that it is prepared by heating and mixing the oil phase part and the aqueous phase part and then passing through a high pressure homogenizer 1 to 5 times under a pressure of 600 to 1,200 bar. Nanoemulsion containing bakuchiol as an active ingredient,
The nanoemulsion containing bakuchiol contains 1.0 to 10.0% by weight of lecithin, 0.1 to 10% by weight of bakuchiol, 0.1 to 10% by weight of antioxidant, and 0.1 to 20% by weight of oil, based on the total weight of the nanoemulsion. Masturbation; and an aqueous phase comprising 30 to 70.0% by weight of polyol and the remaining amount of purified water;
The nanoemulsion is a cosmetic composition for improving skin elasticity, characterized in that it is prepared by heating and mixing the oil phase part and the aqueous phase part and then passing through a high pressure homogenizer 1 to 5 times under a pressure of 600 to 1,200 bar. The cosmetic composition for moisturizing skin according to claim 1, wherein the nanoemulsion containing bakuchiol is contained in an amount of 0.1 to 30.0% by weight based on the total weight of the cosmetic composition. The cosmetic composition for improving skin elasticity according to claim 2, wherein the nanoemulsion containing bakuchiol is contained in an amount of 0.1 to 30.0% by weight based on the total weight of the cosmetic composition.