KR20090099945A - 나복자 추출물을 유효성분으로 함유하는 고지혈증 또는비만의 예방 및 치료용 조성물 - Google Patents
나복자 추출물을 유효성분으로 함유하는 고지혈증 또는비만의 예방 및 치료용 조성물 Download PDFInfo
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- KR20090099945A KR20090099945A KR1020080025256A KR20080025256A KR20090099945A KR 20090099945 A KR20090099945 A KR 20090099945A KR 1020080025256 A KR1020080025256 A KR 1020080025256A KR 20080025256 A KR20080025256 A KR 20080025256A KR 20090099945 A KR20090099945 A KR 20090099945A
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- obesity
- fat
- blood
- hyperlipidemia
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- A23V2200/326—Foods, ingredients or supplements having a functional effect on health having effect on cardiovascular health
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Abstract
Description
정상사료 (g/kg diet) | 고지방 사료 (g/kg diet) | |
Ingredient | ||
Casein | 200 | 200 |
DL-Methionine | 3 | 3 |
Corn starch | 150 | 150 |
Sucrose | 500 | 150 |
Cellulose | 50 | 0 |
Corn Oil | 50 | 0 |
Beef tallow | 0 | 400 |
Mineral mixture | 35 | 35 |
Vitamin mixture | 10 | 10 |
Choline bitartrate | 2 | 2 |
Energy (kJ/g) | 0.91 | 1.30 |
Protein (% kcal/kg) | 13.3 | 13.3 |
Carbohydrate(% kcal/kg) | 47.4 | 19.8 |
Fat (% kcal/kg) | 8.0 | 65.7 |
Fiber (% kcal/kg) | 8.0 | 0 |
Other | 23.3 | 1.3 |
실험군 | 투여량 | 동물수 | 용매 | 기간 | |
Normal diet | 정상사료 대조군 | vehicle only | 10 마리 | 정제수 (10 ml/kg) | 고지방사료는 약물 투여개시 6일 전부터 84일동안 계속 공급 |
40% beef tallow가 함유된 AIN-76A 고지방 사료 | 고지방 사료 대조군 | vehicle only | |||
메타포민 투여군 | 250 mg/kg | ||||
RS 투여군 | 125 mg/kg | ||||
250 mg/kg | |||||
500 mg/kg |
실험군 | 체중 | 체중 증가량 (g) | |
약물투여개시일 | 투여 84일 | ||
대조군 | |||
정상사료 | 27.86± 0.94 | 37.42± 2.48 | 9.56± 2.44 |
고지방 사료 | 33.15± 2.03* | 55.99± 3.79* | 22.84± 3.08* |
메타포민 250 mg/kg | 33.01± 2.24* | 44.22± 2.09*,# | 11.21± 2.19# |
RS 투여군 | |||
500 mg/kg | 33.27± 2.74* | 41.98± 1.92*,# | 8.71± 2.84# |
250 mg/kg | 33.00± 2.13* | 43.83± 2.94*,# | 10.83± 2.66# |
125 mg/kg | 33.00± 2.47* | 50.58± 1.96*,# | 17.58± 2.78*,# |
정상사료에 비하여 통계적 유의성 * p<0.01; 고지방 사료에 비하여 통계적 유의성 # p<0.01 |
실험군 | 난소주위 지방함량 | |
습 중량 (g) | 체중 당 지방 중량 (%) | |
대조군 | ||
정상사료 | 0.067± 0.031 | 0.179± 0.086 |
고지방사료 | 0.829± 0.130* | 1.477± 0.167* |
메타포민 250 mg/kg | 0.291± 0.093*,# | 0.660± 0.208*,# |
RS 투여군 | ||
500 mg/kg | 0.187± 0.028*,# | 0.447± 0.075*,# |
250 mg/kg | 0.278± 0.075*,# | 0.640± 0.188*,# |
125 mg/kg | 0.521± 0.124*,# | 1.038± 0.276*,# |
정상사료에 비하여 통계적 유의성 * p<0.01; 고지방 사료에 비하여 통계적 유의성 # p<0.01 |
Claims (6)
- 나복자의 추출물을 유효성분으로 함유하는 고지혈증 또는 비만의 예방 및 치료용 약학조성물.
- 제 1항에 있어서, 상기 나복자는 십자화과의 무 (Raphanus sativus L.), 갯무 (Raphanus sativus var. hortensis for. raphanistroides Makino) 또는 서양무아재비 (Raphanus raphanistrum L.)의 건조된 종자를 포함함을 특징으로 하는 약학조성물.
- 제 1항에 있어서, 상기 추출물은 정제수를 포함한 물, 탄소수 1 내지 4의 저급알코올 또는 이들의 혼합용매로부터 선택된 용매에 가용한 추출물인 약학조성물.
- 제 1항에 있어서, 조성물 총 중량에 대하여 상기 추출물을 0.1 내지 50% 중량으로 포함됨을 특징으로 하는 약학조성물.
- 나복자의 추출물을 유효성분으로 함유하는 고지혈증 또는 비만의 예방 및 개선용 건강기능식품.
- 제 5항에 있어서, 분말, 과립, 정제, 캡슐, 시럽제 또는 음료인 건강기능식품.
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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KR101897770B1 (ko) * | 2017-10-17 | 2018-09-12 | 한국식품연구원 | 무순 추출물을 포함하는 이상지질혈증 예방 또는 치료용 약학 조성물 |
WO2022225297A1 (ko) * | 2021-04-21 | 2022-10-27 | 한국한의학연구원 | 악액질의 예방, 개선 또는 치료용 조성물 |
KR20220145175A (ko) * | 2021-04-21 | 2022-10-28 | 한국 한의학 연구원 | 밀몽화 추출물을 포함하는 악액질의 예방, 개선 또는 치료용 조성물 |
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KR100682047B1 (ko) * | 2005-03-30 | 2007-02-12 | 정두수 | 고지혈증 치료용 한약 추출물 |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101897770B1 (ko) * | 2017-10-17 | 2018-09-12 | 한국식품연구원 | 무순 추출물을 포함하는 이상지질혈증 예방 또는 치료용 약학 조성물 |
WO2022225297A1 (ko) * | 2021-04-21 | 2022-10-27 | 한국한의학연구원 | 악액질의 예방, 개선 또는 치료용 조성물 |
KR20220145175A (ko) * | 2021-04-21 | 2022-10-28 | 한국 한의학 연구원 | 밀몽화 추출물을 포함하는 악액질의 예방, 개선 또는 치료용 조성물 |
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