KR20090087044A - ＴＡＦＩａ 억제제로서의 요소 및 설파미드 유도체 - Google Patents

ＴＡＦＩａ 억제제로서의 요소 및 설파미드 유도체 Download PDF

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KR20090087044A
KR20090087044A KR1020097011740A KR20097011740A KR20090087044A KR 20090087044 A KR20090087044 A KR 20090087044A KR 1020097011740 A KR1020097011740 A KR 1020097011740A KR 20097011740 A KR20097011740 A KR 20097011740A KR 20090087044 A KR20090087044 A KR 20090087044A
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South Korea
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alkylene
alkyl
phenyl
amino
substituted
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Korean (ko)
Inventor
크리스토퍼 칼루스
마르크 브로엔스트러프
베른가르트 크체흐티츠키
안드레아스 에베르스
마르쿠스 폴만
니스 할란트
헤르만 슈로이더
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사노피-아벤티스
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Publication of KR20090087044A publication Critical patent/KR20090087044A/ko
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
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    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
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US8354444B2 (en) 2008-09-18 2013-01-15 Hoffmann-La Roche Inc. Substituted pyrrolidine-2-carboxamides
AU2009310841A1 (en) * 2008-10-29 2010-05-06 Taisho Pharmaceutical Co., Ltd. Compounds having TAFIa inhibitory activity
EP3027611B1 (en) * 2013-06-10 2017-07-26 Sanofi Macrocyclic urea derivatives as inhibitors of tafi a, their preparation and their use as pharmaceuticals
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RU2687254C1 (ru) * 2018-10-03 2019-05-08 Федеральное государственное бюджетное учреждение науки Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) N-гетероциклические производные борниламина в качестве ингибиторов ортопоксвирусов

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US6482921B1 (en) * 1999-01-28 2002-11-19 Essential Therapeutics, Inc. Uridyl peptide antibiotic (UPA) derivatives, their synthesis and use
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ATE447557T1 (de) * 2000-08-17 2009-11-15 Pfizer Ltd Substitutuierte imidazole als tafia inhibitoren
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US20100035930A1 (en) 2010-02-11
ZA200903040B (en) 2010-02-24
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AU2007327959A1 (en) 2008-06-12
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