KR20090013804A - 할로아릴 치환된 아미노퓨린, 이의 조성물 및 이를 이용한 치료 방법 - Google Patents

할로아릴 치환된 아미노퓨린, 이의 조성물 및 이를 이용한 치료 방법 Download PDF

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Publication number
KR20090013804A
KR20090013804A KR1020087028768A KR20087028768A KR20090013804A KR 20090013804 A KR20090013804 A KR 20090013804A KR 1020087028768 A KR1020087028768 A KR 1020087028768A KR 20087028768 A KR20087028768 A KR 20087028768A KR 20090013804 A KR20090013804 A KR 20090013804A
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South Korea
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substituted
unsubstituted
mmol
kinase
alkyl
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Korean (ko)
Inventor
로날드 제이. 앨버스
레티시아 아얄라
스티븐 에스. 클라린
마리아 메르세데스 델가도 메데로스
로버트 힐그라프
사예 지. 헷지
케빈 휴스
아담 코이스
베로니크 플란테빈-크레니트스키
맥 맥카리크
리사 나돌니
무어티 에스.에스. 팔란키
키란 사하스라무데
존 사피엔자
요시따까 사또
마리안 케이. 슬로스
엘리스 수드벡
조나단 라이트
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시그날 파마소티칼 엘엘씨
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Publication of KR20090013804A publication Critical patent/KR20090013804A/ko
Ceased legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/26Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32Nitrogen atom

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020087028768A 2006-04-26 2007-04-25 할로아릴 치환된 아미노퓨린, 이의 조성물 및 이를 이용한 치료 방법 Ceased KR20090013804A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/411,413 US7521446B2 (en) 2005-01-13 2006-04-26 Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
US11/411,413 2006-04-26

Publications (1)

Publication Number Publication Date
KR20090013804A true KR20090013804A (ko) 2009-02-05

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KR1020087028768A Ceased KR20090013804A (ko) 2006-04-26 2007-04-25 할로아릴 치환된 아미노퓨린, 이의 조성물 및 이를 이용한 치료 방법

Country Status (14)

Country Link
US (2) US7521446B2 (enExample)
EP (1) EP2010186B1 (enExample)
JP (1) JP2009535346A (enExample)
KR (1) KR20090013804A (enExample)
CN (2) CN101478972A (enExample)
AU (1) AU2007243287B2 (enExample)
BR (1) BRPI0710805A2 (enExample)
CA (1) CA2684999C (enExample)
ES (1) ES2400257T3 (enExample)
IL (1) IL194865A (enExample)
MX (1) MX2008013616A (enExample)
NZ (1) NZ572467A (enExample)
WO (1) WO2007127382A1 (enExample)
ZA (3) ZA200809356B (enExample)

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JP2010521157A (ja) 2007-03-14 2010-06-24 ワシントン ユニバーシティ 糖尿病および肥満の治療薬の同定方法
SA08290668B1 (ar) 2007-10-25 2012-02-12 شيونوجي آند كو.، ليمتد مشتقات أمين لها نشاط مضاد لمستقبل npy y5 واستخداماتها
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US8227618B2 (en) * 2009-04-23 2012-07-24 Shionogi & Co., Ltd. Amine-derivatives having NPY Y5 receptor antagonistic activity and the uses thereof
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US11202853B2 (en) * 2010-05-11 2021-12-21 Allergan, Inc. Porogen compositions, methods of making and uses
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US9493464B2 (en) 2012-02-29 2016-11-15 The Scripps Research Institute Wee1 degradation inhibitors
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HRP20211546T1 (hr) 2016-04-01 2022-01-07 Signal Pharmaceuticals, Llc (1s,4s)-4-(2-(((3s,4r)-3-fluortetrahidro-2h-piran-4-il)amino)-8-((2,4,6-triklorfenil)amino)-9h-purin-9-il)-1 -metilcikloheksan-1 -karboksamid i postupci njegove uporabe
CN109476696B (zh) * 2016-06-02 2022-06-10 细胞基因公司 动物及人抗锥虫和抗利什曼原虫剂
US10016436B2 (en) 2016-06-02 2018-07-10 Celgene Corporation Animal and human anti-malarial agents
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CN111417634A (zh) 2017-10-04 2020-07-14 细胞基因公司 用于制备顺式-4-[2-{[(3s,4r)-3-氟噁烷-4-基]氨基}-8-(2,4,6-三氯苯胺基)-9h-嘌呤-9-基]-1-甲基环己烷-1-甲酰胺的方法
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Also Published As

Publication number Publication date
IL194865A0 (en) 2009-08-03
MX2008013616A (es) 2009-03-06
AU2007243287A1 (en) 2007-11-08
CA2684999C (en) 2013-11-26
ZA200907418B (en) 2011-12-28
CN101478972A (zh) 2009-07-08
BRPI0710805A2 (pt) 2011-08-16
US7521446B2 (en) 2009-04-21
NZ572467A (en) 2010-10-29
IL194865A (en) 2015-08-31
WO2007127382A1 (en) 2007-11-08
ES2400257T3 (es) 2013-04-08
US8101588B2 (en) 2012-01-24
CA2684999A1 (en) 2007-11-08
US20070060598A1 (en) 2007-03-15
ZA200809356B (en) 2010-02-24
US20090275564A1 (en) 2009-11-05
JP2009535346A (ja) 2009-10-01
EP2010186A1 (en) 2009-01-07
AU2007243287B2 (en) 2012-02-16
ZA201103036B (en) 2012-08-29
CN103351389A (zh) 2013-10-16
EP2010186B1 (en) 2012-12-26
CN103351389B (zh) 2015-10-28

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