KR20080039442A - 스테로이드 니트록시 유도체들 - Google Patents
스테로이드 니트록시 유도체들 Download PDFInfo
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- KR20080039442A KR20080039442A KR1020087004591A KR20087004591A KR20080039442A KR 20080039442 A KR20080039442 A KR 20080039442A KR 1020087004591 A KR1020087004591 A KR 1020087004591A KR 20087004591 A KR20087004591 A KR 20087004591A KR 20080039442 A KR20080039442 A KR 20080039442A
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 16
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- 125000000217 alkyl group Chemical group 0.000 claims description 36
- -1 nitromethyl Chemical group 0.000 claims description 36
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 26
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 24
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- 125000001153 fluoro group Chemical group F* 0.000 claims description 23
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- 229910002651 NO3 Inorganic materials 0.000 claims description 6
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims description 6
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- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 6
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 6
- ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 claims description 6
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- 125000000623 heterocyclic group Chemical group 0.000 claims description 6
- IIPYXGDZVMZOAP-UHFFFAOYSA-N lithium nitrate Chemical compound [Li+].[O-][N+]([O-])=O IIPYXGDZVMZOAP-UHFFFAOYSA-N 0.000 claims description 6
- YIXJRHPUWRPCBB-UHFFFAOYSA-N magnesium nitrate Chemical compound [Mg+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O YIXJRHPUWRPCBB-UHFFFAOYSA-N 0.000 claims description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
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- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 claims description 6
- 229920006395 saturated elastomer Polymers 0.000 claims description 6
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 claims description 6
- 239000011593 sulfur Chemical group 0.000 claims description 6
- 229910052717 sulfur Inorganic materials 0.000 claims description 6
- ONDPHDOFVYQSGI-UHFFFAOYSA-N zinc nitrate Chemical compound [Zn+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ONDPHDOFVYQSGI-UHFFFAOYSA-N 0.000 claims description 6
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- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims description 4
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- 125000003031 C5-C7 cycloalkylene group Chemical group 0.000 claims description 4
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- 239000003054 catalyst Substances 0.000 claims description 4
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- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 239000000249 polyoxyethylene sorbitan monopalmitate Substances 0.000 description 1
- 235000010483 polyoxyethylene sorbitan monopalmitate Nutrition 0.000 description 1
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
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- 229940101027 polysorbate 40 Drugs 0.000 description 1
- 229940113124 polysorbate 60 Drugs 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
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- 239000011591 potassium Substances 0.000 description 1
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- 239000002243 precursor Substances 0.000 description 1
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- 201000009395 primary hyperaldosteronism Diseases 0.000 description 1
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- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
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- 235000013772 propylene glycol Nutrition 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- LVTJOONKWUXEFR-FZRMHRINSA-N protoneodioscin Natural products O(C[C@@H](CC[C@]1(O)[C@H](C)[C@@H]2[C@]3(C)[C@H]([C@H]4[C@@H]([C@]5(C)C(=CC4)C[C@@H](O[C@@H]4[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@H](CO)O4)CC5)CC3)C[C@@H]2O1)C)[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1 LVTJOONKWUXEFR-FZRMHRINSA-N 0.000 description 1
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- 238000011160 research Methods 0.000 description 1
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- 231100000444 skin lesion Toxicity 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
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- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
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- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
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- 229960001600 xylazine Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05019155.0 | 2005-09-02 | ||
| EP05019155 | 2005-09-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20080039442A true KR20080039442A (ko) | 2008-05-07 |
Family
ID=37450883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020087004591A Ceased KR20080039442A (ko) | 2005-09-02 | 2006-08-04 | 스테로이드 니트록시 유도체들 |
Country Status (19)
| Country | Link |
|---|---|
| US (5) | US20080221073A1 (https=) |
| EP (1) | EP1940863B1 (https=) |
| JP (1) | JP5216589B2 (https=) |
| KR (1) | KR20080039442A (https=) |
| CN (2) | CN101300265A (https=) |
| AR (1) | AR056868A1 (https=) |
| AU (1) | AU2006286838C1 (https=) |
| BR (1) | BRPI0614967A2 (https=) |
| CA (1) | CA2621117A1 (https=) |
| ES (1) | ES2393363T3 (https=) |
| IL (2) | IL189337A0 (https=) |
| NO (1) | NO20081614L (https=) |
| NZ (1) | NZ566128A (https=) |
| RU (1) | RU2415864C2 (https=) |
| SG (1) | SG158916A1 (https=) |
| TW (1) | TW200801031A (https=) |
| UY (1) | UY29779A1 (https=) |
| WO (1) | WO2007025632A2 (https=) |
| ZA (1) | ZA200801789B (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8802726B2 (en) | 2006-02-03 | 2014-08-12 | Nicox S.A. | Use of nitrooxyderivative of drug for the treatment of muscular dystrophies |
| BRPI0807078A2 (pt) * | 2007-02-05 | 2014-04-08 | Nicox Sa | Composto, e, formulação farmacêutica |
| EP1964550A1 (en) * | 2007-03-01 | 2008-09-03 | NicOx S.A. | Glucocorticoid-nitrooxyderivative compositions |
| ES2324007A1 (es) * | 2007-10-25 | 2009-07-28 | Ferrer Internacional, S.A. | Una forma amorfa de un compuesto antiinflamatorio. |
| ES2442720T3 (es) * | 2008-07-31 | 2014-02-13 | Nicox S.A. | Glucocorticoides unidos a ésteres de nitrato por medio de un enlazador aromático en posición 21 y su uso en oftalmología |
| CN102186873A (zh) * | 2008-08-05 | 2011-09-14 | 尼科克斯公司 | 用于治疗视网膜和黄斑疾病的新型释放no的甾类化合物 |
| CN102186874A (zh) * | 2008-08-05 | 2011-09-14 | 尼科克斯公司 | 新的释放no的类固醇衍生物 |
| US8062653B2 (en) | 2009-02-18 | 2011-11-22 | Bezwada Biomedical, Llc | Controlled release of nitric oxide and drugs from functionalized macromers and oligomers |
| EP2398761A4 (en) * | 2009-02-18 | 2015-11-04 | Bezwada Biomedical Llc | CONTROLLED RELEASE OF NITRIC OXIDE AND MEDICINES FROM FUNCTIONALIZED MACROMERS AND OLIGOMERS |
| US9022788B2 (en) * | 2009-10-17 | 2015-05-05 | Gregory John Stahler | System and method for cardiac defibrillation response simulation in health training mannequin |
| ES2359708B1 (es) * | 2009-11-16 | 2012-03-30 | Ferrer Internacional S.A. | Procedimiento de preparación de la (11beta,16alfa)-9-fluoro-11-hidroxi-16,17-[1-metil-etilidenebis(oxi)]-21-[1-oxo-[4-(nitrooximetil)benzoxi]]preña-1,4-dien-3,20-diona. |
| ES2362894B1 (es) | 2009-11-16 | 2012-05-21 | Ferrer Internacional S.A. | Procedimiento de preparación del �?cido 4-nitro-oxi-metil-benzoico. |
| CN110382033B (zh) * | 2016-10-14 | 2022-04-15 | 范安德尔研究所 | 用于设计高效力糖皮质激素的结构与机制 |
| AU2021241591A1 (en) | 2020-03-24 | 2022-10-20 | Michael W. BURNET | Anti-infective and anti-viral compounds and compositions |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56138200A (en) | 1980-02-15 | 1981-10-28 | Glaxo Group Ltd | Androstane carbothioate compound |
| GR1001529B (el) * | 1990-09-07 | 1994-03-31 | Elmuquimica Farm Sl | Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης. |
| US5824669A (en) * | 1996-03-22 | 1998-10-20 | Nitromed, Inc. | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders |
| US5985862A (en) * | 1996-05-02 | 1999-11-16 | G.D. Searle & Co. | Pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs |
| US5837698A (en) * | 1996-05-02 | 1998-11-17 | G. D. Searle & Co. | Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs |
| IT1285770B1 (it) * | 1996-10-04 | 1998-06-18 | Nicox Sa | Composti corticoidei |
| IT1311922B1 (it) | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| ITMI20020148A1 (it) * | 2002-01-29 | 2003-07-29 | Nicox Sa | Nuovi corticosteroidi |
| EP1336602A1 (en) * | 2002-02-13 | 2003-08-20 | Giovanni Scaramuzzino | Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases |
-
2006
- 2006-08-04 EP EP06776617A patent/EP1940863B1/en active Active
- 2006-08-04 BR BRPI0614967-7A patent/BRPI0614967A2/pt not_active IP Right Cessation
- 2006-08-04 CN CNA2006800405622A patent/CN101300265A/zh active Pending
- 2006-08-04 WO PCT/EP2006/007746 patent/WO2007025632A2/en not_active Ceased
- 2006-08-04 US US12/065,561 patent/US20080221073A1/en not_active Abandoned
- 2006-08-04 SG SG201000520-5A patent/SG158916A1/en unknown
- 2006-08-04 AU AU2006286838A patent/AU2006286838C1/en not_active Ceased
- 2006-08-04 NZ NZ566128A patent/NZ566128A/en not_active IP Right Cessation
- 2006-08-04 CA CA002621117A patent/CA2621117A1/en not_active Abandoned
- 2006-08-04 JP JP2008528372A patent/JP5216589B2/ja not_active Expired - Fee Related
- 2006-08-04 RU RU2008111076/04A patent/RU2415864C2/ru not_active IP Right Cessation
- 2006-08-04 CN CN2011100265155A patent/CN102134269A/zh active Pending
- 2006-08-04 ES ES06776617T patent/ES2393363T3/es active Active
- 2006-08-04 KR KR1020087004591A patent/KR20080039442A/ko not_active Ceased
- 2006-09-01 AR ARP060103835A patent/AR056868A1/es not_active Application Discontinuation
- 2006-09-01 UY UY29779A patent/UY29779A1/es unknown
- 2006-09-01 TW TW095132322A patent/TW200801031A/zh unknown
-
2008
- 2008-02-07 IL IL189337A patent/IL189337A0/en unknown
- 2008-02-25 ZA ZA200801789A patent/ZA200801789B/xx unknown
- 2008-04-01 NO NO20081614A patent/NO20081614L/no not_active Application Discontinuation
-
2009
- 2009-06-26 US US12/492,337 patent/US20090264393A1/en not_active Abandoned
- 2009-06-26 US US12/492,359 patent/US20090258849A1/en not_active Abandoned
- 2009-06-26 US US12/492,404 patent/US20090264394A1/en not_active Abandoned
-
2011
- 2011-08-10 US US13/207,231 patent/US20110294769A1/en not_active Abandoned
- 2011-11-22 IL IL216516A patent/IL216516A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20080221073A1 (en) | 2008-09-11 |
| AR056868A1 (es) | 2007-10-31 |
| WO2007025632A3 (en) | 2007-04-19 |
| US20090264393A1 (en) | 2009-10-22 |
| IL189337A0 (en) | 2008-06-05 |
| US20090264394A1 (en) | 2009-10-22 |
| JP5216589B2 (ja) | 2013-06-19 |
| AU2006286838C1 (en) | 2013-05-02 |
| US20110294769A1 (en) | 2011-12-01 |
| IL216516A0 (en) | 2011-12-29 |
| AU2006286838B2 (en) | 2012-03-29 |
| EP1940863A2 (en) | 2008-07-09 |
| WO2007025632A2 (en) | 2007-03-08 |
| CN102134269A (zh) | 2011-07-27 |
| CA2621117A1 (en) | 2007-03-08 |
| SG158916A1 (en) | 2010-02-26 |
| RU2415864C2 (ru) | 2011-04-10 |
| JP2009506994A (ja) | 2009-02-19 |
| ES2393363T3 (es) | 2012-12-20 |
| ZA200801789B (en) | 2008-12-31 |
| RU2008111076A (ru) | 2009-10-10 |
| AU2006286838A1 (en) | 2007-03-08 |
| EP1940863B1 (en) | 2012-09-05 |
| BRPI0614967A2 (pt) | 2013-01-01 |
| US20090258849A1 (en) | 2009-10-15 |
| TW200801031A (en) | 2008-01-01 |
| NZ566128A (en) | 2011-03-31 |
| UY29779A1 (es) | 2006-12-29 |
| CN101300265A (zh) | 2008-11-05 |
| NO20081614L (no) | 2008-05-28 |
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