KR20080007376A - 무정형 시나칼셋 염산염 및 이의 제조 - Google Patents

무정형 시나칼셋 염산염 및 이의 제조 Download PDF

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Publication number
KR20080007376A
KR20080007376A KR1020077027080A KR20077027080A KR20080007376A KR 20080007376 A KR20080007376 A KR 20080007376A KR 1020077027080 A KR1020077027080 A KR 1020077027080A KR 20077027080 A KR20077027080 A KR 20077027080A KR 20080007376 A KR20080007376 A KR 20080007376A
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KR
South Korea
Prior art keywords
solvent
cinacalcet
amorphous
temperature
cinacalcet hydrochloride
Prior art date
Application number
KR1020077027080A
Other languages
English (en)
Korean (ko)
Inventor
레비털 리프쉬츠-리론
마이클 핀차소브
슐로미트 위젤
샤론 아브하르-메이단
Original Assignee
테바 파마슈티컬 인더스트리즈 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 테바 파마슈티컬 인더스트리즈 리미티드 filed Critical 테바 파마슈티컬 인더스트리즈 리미티드
Publication of KR20080007376A publication Critical patent/KR20080007376A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/62—Quaternary ammonium compounds
    • C07C211/63—Quaternary ammonium compounds having quaternised nitrogen atoms bound to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/30—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system formed by two rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020077027080A 2005-05-23 2006-05-23 무정형 시나칼셋 염산염 및 이의 제조 KR20080007376A (ko)

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US68415205P 2005-05-23 2005-05-23
US60/684,152 2005-05-23
US69861305P 2005-07-11 2005-07-11
US60/698,613 2005-07-11
US70291805P 2005-07-26 2005-07-26
US60/702,918 2005-07-26
US73466905P 2005-11-07 2005-11-07
US60/734,669 2005-11-07
US73882705P 2005-11-21 2005-11-21
US60/738,827 2005-11-21
US73921505P 2005-11-22 2005-11-22
US60/739,215 2005-11-22
US74262605P 2005-12-05 2005-12-05
US60/742,626 2005-12-05
US75091005P 2005-12-15 2005-12-15
US60/750,910 2005-12-15

Publications (1)

Publication Number Publication Date
KR20080007376A true KR20080007376A (ko) 2008-01-18

Family

ID=37101654

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020077027080A KR20080007376A (ko) 2005-05-23 2006-05-23 무정형 시나칼셋 염산염 및 이의 제조

Country Status (8)

Country Link
US (1) US7368606B2 (fr)
EP (1) EP1883625A2 (fr)
JP (1) JP2008507567A (fr)
KR (1) KR20080007376A (fr)
CA (1) CA2605764A1 (fr)
IL (1) IL185495A0 (fr)
MX (1) MX2007000982A (fr)
WO (1) WO2006127941A2 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007112280A1 (fr) 2006-03-23 2007-10-04 Amgen Inc. Procédés et compositions pour la fabrication et l'utilisation de polymorphes du cinacalcet
US20090258949A1 (en) * 2006-06-27 2009-10-15 Johannes Ludescher Amorphous form of cinacalcet
EP1914224A1 (fr) * 2006-10-19 2008-04-23 Sandoz AG Chlohydrate de cinacalcete amorphe
WO2008027522A2 (fr) * 2006-09-01 2008-03-06 Teva Pharmaceutical Industries Ltd. Composites solides d'un composé actif vis-à-vis du récepteur calcique
WO2008058236A2 (fr) * 2006-11-08 2008-05-15 Dr. Reddy's Labortories, Ltd. Procédés de préparation d'hydrochlorure de cinacalcet
WO2008063888A2 (fr) 2006-11-22 2008-05-29 Plexxikon, Inc. Composés modulant l'activité de c-fms et/ou de c-kit et utilisations associées
EP2170805B1 (fr) * 2007-06-21 2016-03-16 Amgen Inc. Procédés de synthèse du cinacalcet et de ses sels
US20090093652A1 (en) * 2007-08-16 2009-04-09 Michal Rafilovich Crystalline forms cinacalcet fumarate and cinacalcet succinate and processes for preparation thereof
US20110172455A1 (en) * 2008-07-08 2011-07-14 Ind-Swift Laboratories Limited Process for preparing cinacalcet and pharmaceutically acceptable salts thereof
WO2010067204A1 (fr) 2008-12-08 2010-06-17 Actavis Group Ptc Ehf Cinacalcet de pureté élevée ou l'un de ses sels de qualité pharmaceutique
CN110269838A (zh) * 2009-04-03 2019-09-24 豪夫迈罗氏公司 丙烷-1-磺酸{3-[5-(4-氯-苯基)-1H-吡咯并[2,3-b]吡啶-3-羰基]-2,4-二氟-苯基}-酰胺组合物及其用途
CA2780190C (fr) 2009-11-06 2020-05-05 Plexxikon, Inc. Composes et methodes de modulation des kinases et leurs indications d'emploi
JP5356323B2 (ja) * 2010-07-01 2013-12-04 富士化学工業株式会社 新規な非晶質ボセンタン及びその製造方法
CN101941911A (zh) * 2010-09-21 2011-01-12 上海应用技术学院 一种西纳卡塞的绿色合成方法
LT2672967T (lt) 2011-02-07 2018-12-10 Plexxikon Inc. Junginiai ir būdai skirti kinazės moduliavimui, ir jų indikacijos
AR085279A1 (es) 2011-02-21 2013-09-18 Plexxikon Inc Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
FR2995307A1 (fr) 2012-09-07 2014-03-14 Prod Chim Auxiliaires Et De Synthese Procede de preparation du cinacalcet et de ses sels pharmaceutiquement acceptables
CN109928881A (zh) * 2017-12-18 2019-06-25 浙江万晟药业有限公司 一种盐酸西那卡塞的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4966988A (en) * 1989-02-17 1990-10-30 Chevron Research Company Process for preparing acetonitrile 3-trifluoromethyl benzene
US6313146B1 (en) * 1991-08-23 2001-11-06 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6011068A (en) * 1991-08-23 2000-01-04 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6031003A (en) * 1991-08-23 2000-02-29 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
CN1312116C (zh) * 1994-10-21 2007-04-25 Nps药物有限公司 钙受体活性化合物
US5648541A (en) * 1995-09-28 1997-07-15 Nps Pharmaceuticals, Inc. Chiral reductions of imines leading to the syntheses of optically active amines
EP2316442A1 (fr) * 2003-09-12 2011-05-04 Amgen Inc. Composition à base de composé actif aux récepteurs au calcium, à vitesse de dissolution rapide
US20050234261A1 (en) * 2004-04-14 2005-10-20 Honeywell International Inc. Process for preparing cinnamic acids and alkyl esters thereof
MX2007011153A (es) * 2005-03-17 2007-12-12 Amgen Inc Metodos para reducir la calcificacion.
ES2332016T3 (es) 2005-05-16 2010-01-22 Teva Pharmaceutical Industries Ltd. Procedimiento para la preparacion de hidrocloruro de cinacalcet.

Also Published As

Publication number Publication date
US7368606B2 (en) 2008-05-06
JP2008507567A (ja) 2008-03-13
CA2605764A1 (fr) 2006-11-30
IL185495A0 (en) 2008-01-06
WO2006127941A2 (fr) 2006-11-30
WO2006127941A3 (fr) 2007-01-18
US20070054963A1 (en) 2007-03-08
WO2006127941A9 (fr) 2007-12-06
MX2007000982A (es) 2007-04-16
EP1883625A2 (fr) 2008-02-06

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E902 Notification of reason for refusal
E601 Decision to refuse application