KR20070121026A - 환자에 있어서 부정적 영향을 방지하거나 감소시키기 위한방법, 조성물 및 제제 - Google Patents

환자에 있어서 부정적 영향을 방지하거나 감소시키기 위한방법, 조성물 및 제제 Download PDF

Info

Publication number
KR20070121026A
KR20070121026A KR1020077024883A KR20077024883A KR20070121026A KR 20070121026 A KR20070121026 A KR 20070121026A KR 1020077024883 A KR1020077024883 A KR 1020077024883A KR 20077024883 A KR20077024883 A KR 20077024883A KR 20070121026 A KR20070121026 A KR 20070121026A
Authority
KR
South Korea
Prior art keywords
patient
surgery
amino
salt
prodrug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020077024883A
Other languages
English (en)
Korean (ko)
Inventor
데니스 티. 만가노
Original Assignee
페리코르 테라퓨틱스, 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 페리코르 테라퓨틱스, 인크. filed Critical 페리코르 테라퓨틱스, 인크.
Publication of KR20070121026A publication Critical patent/KR20070121026A/ko
Ceased legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/60Salicylic acid; Derivatives thereof
    • A61K31/612Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020077024883A 2005-03-28 2006-03-28 환자에 있어서 부정적 영향을 방지하거나 감소시키기 위한방법, 조성물 및 제제 Ceased KR20070121026A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66607105P 2005-03-28 2005-03-28
US60/666,071 2005-03-28

Publications (1)

Publication Number Publication Date
KR20070121026A true KR20070121026A (ko) 2007-12-26

Family

ID=37054068

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020077024883A Ceased KR20070121026A (ko) 2005-03-28 2006-03-28 환자에 있어서 부정적 영향을 방지하거나 감소시키기 위한방법, 조성물 및 제제

Country Status (14)

Country Link
US (3) US8993527B2 (enExample)
EP (3) EP3132796A1 (enExample)
JP (9) JP2008534601A (enExample)
KR (1) KR20070121026A (enExample)
CN (1) CN101184495B (enExample)
AU (1) AU2006230242B2 (enExample)
BR (1) BRPI0608654C1 (enExample)
CA (1) CA2602291C (enExample)
MX (1) MX2007012045A (enExample)
NO (1) NO342207B1 (enExample)
NZ (1) NZ561649A (enExample)
SG (3) SG194352A1 (enExample)
WO (1) WO2006105167A2 (enExample)
ZA (1) ZA200708277B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008007216A1 (de) 2007-05-29 2008-12-11 Samsung Electro - Mechanics Co., Ltd., Suwon Gedruckte Leiterplatte und Herstellungsverfahren derselben

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG194352A1 (en) 2005-03-28 2013-11-29 Pericor Therapeutics Inc Methods, compositions, and formulations for preventing or reducing adverse effects in a patient
US20070082859A1 (en) * 2005-10-07 2007-04-12 Stover Richard R Formulations of AICA riboside
WO2008086341A1 (en) * 2007-01-09 2008-07-17 Pericor Therapeutics, Inc. Methods. compositions, and formulations for preventing or reducing adverse effects in a patient
EP3753565A1 (en) * 2008-10-03 2020-12-23 ViCardia Therapeutics, Inc. Aica riboside analogs for treatment of cardiac and other conditions
WO2011075391A1 (en) * 2009-12-15 2011-06-23 Schering Corporation Formulations of acadesine
US8489182B2 (en) 2011-10-18 2013-07-16 General Electric Company System and method of quality analysis in acquisition of ambulatory electrocardiography device data
JP6593595B2 (ja) 2014-01-15 2019-10-23 正道 山本 Atp可視化動物およびその用途
CN112656780A (zh) 2014-02-20 2021-04-16 奥迪托皮克股份有限公司 用于吸入的干粉制剂
CN104140438B (zh) * 2014-06-11 2017-01-18 苏州景泓生物技术有限公司 5‑氨基‑4‑氨甲酰咪唑核苷碳环类似物的合成方法
CN116687887A (zh) 2014-07-31 2023-09-05 维克图拉公司 用于吸入的干粉制剂
WO2016176552A1 (en) * 2015-04-30 2016-11-03 Otitopic Inc. Dry power formulations for inhalation
JP6937134B2 (ja) 2016-11-21 2021-09-22 株式会社スタージェン 細胞内atp増強剤
WO2018092911A1 (ja) * 2016-11-21 2018-05-24 株式会社スタージェン 細胞内atp増強剤
JP7137225B2 (ja) * 2017-08-21 2022-09-14 国立大学法人三重大学 非ヒト哺乳類の脳梗塞モデルによる観察方法及び非ヒト哺乳類の脳梗塞モデルによる観察装置
EP4040991A4 (en) * 2019-10-09 2024-01-24 Mayo Foundation for Medical Education and Research TREATMENT OF GASTROINTESTINAL DISORDERS
EP3866176A1 (en) * 2020-02-17 2021-08-18 Siemens Healthcare GmbH Machine-based risk prediction for peri-procedural myocardial infarction or complication from medical data
US11266376B2 (en) 2020-06-19 2022-03-08 Ultrasound Ai Inc. Premature birth prediction
US12369883B2 (en) 2020-06-19 2025-07-29 Ultrasound AI, Inc. Artificial intelligence system for determining clinical values through medical imaging
WO2024073384A2 (en) * 2022-09-26 2024-04-04 The Penn State Research Foundation Anticoagulant-peptide nanogranules for thrombosis-actuated anticoagulation
WO2024192175A1 (en) * 2023-03-13 2024-09-19 Ultrasound AI, Inc. Artificial intelligence system for comprehensive medical diagnosis, prognosis, and treatment optimization through medical imaging

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1645976A1 (de) 1966-06-18 1971-01-21 Ajinomoto Kk Verfahren zur Herstellung von Adenosin und 2',3'-O-Isopropylidenadenosin
JPS4944349B1 (enExample) * 1967-06-16 1974-11-27
US4211771A (en) * 1971-06-01 1980-07-08 Robins Ronald K Treatment of human viral diseases with 1-B-D-ribofuranosyl-1,2,4-triazole-3-carboxamide
AT350735B (de) 1976-08-06 1979-06-11 Hoffmann La Roche Verfahren zur herstellung von neuen ribo- furanosyl-imidazolderivaten
EP0066909A3 (en) * 1981-05-15 1984-03-07 FISONS plc Imidazole derivatives, pharmaceutical compositions containing them and processes for their production
US4575498A (en) * 1983-07-21 1986-03-11 Duke University Method for restoring depleted purine nucleotide pools
US5008251A (en) * 1986-03-27 1991-04-16 The Regents Of The University Of California Method of treating autism
WO1987005807A1 (en) 1986-03-27 1987-10-08 Harry Edward Gruber A method of increasing adenosine excretion
US4912092A (en) 1986-03-27 1990-03-27 The Regents Of The University Of California Methods for increasing extracellular adenosine and for stabilizing mast cells
US5030623A (en) * 1986-03-27 1991-07-09 The Regents Of The University Of California Methods for increasing extracellular adenosine and for stabilizing mast cells
US5118601A (en) * 1986-03-27 1992-06-02 The Regents Of The University Of California Method of screening purine nucleoside compounds or analogs for the ability to enhance the cellular synthesis and release of adenosine
US5132291A (en) * 1989-01-24 1992-07-21 Gensia Pharmaceuticals, Inc. Antivirals and methods for increasing the antiviral activity of azt
US5200525A (en) * 1989-01-24 1993-04-06 Gensia Pharmaceuticals Anti-seizure compounds
US5658889A (en) * 1989-01-24 1997-08-19 Gensia Pharmaceuticals, Inc. Method and compounds for aica riboside delivery and for lowering blood glucose
US5082829A (en) * 1989-01-24 1992-01-21 Gensia Pharmaceuticals AICA riboside prodrugs
US5187162A (en) * 1989-09-15 1993-02-16 Gensia Pharmaceuticals Methods of treating neurodegenerative conditions
US5646128A (en) 1989-09-15 1997-07-08 Gensia, Inc. Methods for treating adenosine kinase related conditions
US5777100A (en) * 1990-08-10 1998-07-07 Gensia Inc. AICA riboside analogs
IL99124A (en) 1990-08-10 1998-02-22 Gensia Pharma Substituted imidazole analogs of aica riboside
IL99125A0 (en) * 1990-08-10 1992-07-15 Gensia Pharma Derivatives of imidazole analog of aica riboside and their use
IL103294A0 (en) 1991-09-30 1993-05-13 Gensia Pharma Pharmaceutical compositions for preventing tissue damage associated with decreased blood flow
DE69327796T2 (de) * 1992-12-16 2000-06-21 Agouron Pharmaceuticals , Inc. Antiproliferative substituierte 5-thiapyrimidinon- und 5-selenopyrimidinonverbindungen
IL108524A0 (en) * 1993-02-03 1994-05-30 Gensia Inc Imidazodiazepine analogs
US5366960A (en) * 1993-08-26 1994-11-22 Warner-Lambert Company Method of treating cerebral and cardiovascular disorders employing [R]3-(2-deoxy-β-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidaz 0-[4,5-d][1,3]diazepin-8-ol
US5629298A (en) * 1995-03-13 1997-05-13 University Of Massachusetts Medical Center Adenosine as a positive inotrop in the compromised heart
US5645128A (en) * 1995-06-05 1997-07-08 Schwall; Charles F. Fire safety grease seal
US5998386A (en) * 1997-09-19 1999-12-07 Feldman; Arthur M. Pharmaceutical compositions and method of using same for the treatment of failing myocardial tissue
US20040072138A1 (en) 1997-11-25 2004-04-15 Medical University Of South Carolina Attenuation of ischemia/reperfusion injury
WO1999026657A1 (en) 1997-11-25 1999-06-03 Musc Foundation For Research Development Inhibitors of nitric oxide synthase
US6103702A (en) * 1999-05-24 2000-08-15 Board Of Trustees Of The University Of Illinois Use of adenosine deaminase inhibitors to treat systemic inflammatory response syndrome
EP1492564A2 (en) 2001-10-31 2005-01-05 Université Libre de Bruxelles Amp-kinase agonists or adenosine pro-drugs as immuno-stimulating agents
ES2192495B1 (es) * 2002-03-21 2005-02-16 Universidad De Barcelona Nuevo uso terapeutico del ribosido de 5-aminoimidazol-4-carboxamida (acadesina).
SG194352A1 (en) 2005-03-28 2013-11-29 Pericor Therapeutics Inc Methods, compositions, and formulations for preventing or reducing adverse effects in a patient
US20070082859A1 (en) * 2005-10-07 2007-04-12 Stover Richard R Formulations of AICA riboside
WO2008086341A1 (en) 2007-01-09 2008-07-17 Pericor Therapeutics, Inc. Methods. compositions, and formulations for preventing or reducing adverse effects in a patient
US8710018B2 (en) 2008-01-25 2014-04-29 John E. Foker Methods and compositions for inhibiting progression to chronic cardiac failure

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008007216A1 (de) 2007-05-29 2008-12-11 Samsung Electro - Mechanics Co., Ltd., Suwon Gedruckte Leiterplatte und Herstellungsverfahren derselben

Also Published As

Publication number Publication date
JP2025084893A (ja) 2025-06-03
JP6122417B2 (ja) 2017-04-26
US8993527B2 (en) 2015-03-31
SG194352A1 (en) 2013-11-29
BRPI0608654B8 (pt) 2020-10-27
JP2013010795A (ja) 2013-01-17
JP2019089853A (ja) 2019-06-13
CN101184495B (zh) 2011-09-14
SG10201704913RA (en) 2017-07-28
ZA200708277B (en) 2011-03-30
NZ561649A (en) 2011-02-25
WO2006105167A3 (en) 2007-05-10
JP2015057436A (ja) 2015-03-26
CN101184495A (zh) 2008-05-21
US20150272978A1 (en) 2015-10-01
EP1863497A2 (en) 2007-12-12
CA2602291A1 (en) 2006-10-05
EP1863497A4 (en) 2009-08-12
NO20075400L (no) 2007-12-19
US9539274B2 (en) 2017-01-10
JP2008534601A (ja) 2008-08-28
CA2602291C (en) 2015-08-11
MX2007012045A (es) 2008-01-16
JP2017057222A (ja) 2017-03-23
JP2013010794A (ja) 2013-01-17
EP2594273A1 (en) 2013-05-22
BRPI0608654C1 (pt) 2021-05-25
JP7093739B2 (ja) 2022-06-30
EP3132796A1 (en) 2017-02-22
WO2006105167A2 (en) 2006-10-05
NO342207B1 (no) 2018-04-16
SG160425A1 (en) 2010-04-29
AU2006230242A1 (en) 2006-10-05
BRPI0608654A2 (pt) 2010-01-19
AU2006230242B2 (en) 2013-05-30
BRPI0608654B1 (pt) 2020-09-29
JP2020152737A (ja) 2020-09-24
US20170216335A1 (en) 2017-08-03
US20060293273A1 (en) 2006-12-28
JP2022093641A (ja) 2022-06-23

Similar Documents

Publication Publication Date Title
JP7093739B2 (ja) 患者における副作用を予防または減少するための方法、組成物および処方物
US4912092A (en) Methods for increasing extracellular adenosine and for stabilizing mast cells
US5658889A (en) Method and compounds for aica riboside delivery and for lowering blood glucose
JPH11509181A (ja) 水溶性アデノシンキナーゼ阻害剤
US5030623A (en) Methods for increasing extracellular adenosine and for stabilizing mast cells
US5008251A (en) Method of treating autism
US5777100A (en) AICA riboside analogs
US5082829A (en) AICA riboside prodrugs
AU5668886A (en) A method of increasing adenosine excretion
HK1234668A1 (en) Methods, compositions, and formulations for preventing or reducing adverse effects in a patient
WO1998055494A1 (en) Treatmemt and prophylaxis of infarction by dinucleotides
Abd-Elfattah et al. Is Adenosine 5′-Triphosphate Derangement or Free-Radical-AMediated Injury the Major Cause of Ventricular Dysfunction During Reperfusion?: Role of Adenine Nucleoside Transport in Myocardial Reperfusion Injury

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20071026

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20110325

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20130219

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20130730

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20130219

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I