KR20070042567A - 글리세롤 분지쇄 폴리에틸렌 글리콜 인간 성장 호르몬공액체, 이의 제조 방법 및 이의 사용 방법 - Google Patents
글리세롤 분지쇄 폴리에틸렌 글리콜 인간 성장 호르몬공액체, 이의 제조 방법 및 이의 사용 방법 Download PDFInfo
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DE69838552T2 (de) | 1997-07-14 | 2008-05-21 | Bolder Biotechnology, Inc., Louisville | Derivate des wachstumshormons und verwandte proteine |
US7495087B2 (en) | 1997-07-14 | 2009-02-24 | Bolder Biotechnology, Inc. | Cysteine muteins in the C-D loop of human interleukin-11 |
EP2305804B1 (en) | 1999-01-14 | 2015-05-06 | Bolder Biotechnology, Inc. | MonoPEGylated human growth hormone |
US7855279B2 (en) | 2005-09-27 | 2010-12-21 | Amunix Operating, Inc. | Unstructured recombinant polymers and uses thereof |
EP1834963A1 (en) * | 2006-03-13 | 2007-09-19 | Siegfried Ltd. | Di-polymer protein conjugates and processes for their preparation |
US20090117077A1 (en) * | 2006-05-12 | 2009-05-07 | Dong-A Pharm. Co., Ltd. | Polyethylene glycol-interferon alpha conjugate |
JP2008069073A (ja) * | 2006-09-12 | 2008-03-27 | Yokohama Tlo Co Ltd | ラクトフェリン複合体及びその製造方法 |
KR101079993B1 (ko) * | 2006-11-17 | 2011-11-04 | 동아제약주식회사 | 폴리에틸렌글리콜 과립구 콜로니 자극인자 접합체 |
CL2008002399A1 (es) | 2007-08-16 | 2009-01-02 | Pharmaessentia Corp | Conjugado sustancialmente puro que posee una porcion polimerica, una porcion proteica (interferon alfa 2b) y un ligante alifatico de 1 a 10 atomos de carbono, util en el tratamiento de las hepatitis b o c. |
EP2300501B1 (en) * | 2008-07-23 | 2014-08-20 | Hanmi Science Co., Ltd. | A polypeptide complex comprising non-peptidyl polymer having three functional ends |
EA020347B1 (ru) | 2008-07-31 | 2014-10-30 | Фармаиссэншиа Корп. | Пептид-полимерные конъюгаты |
US8535655B2 (en) | 2008-10-10 | 2013-09-17 | Polyactiva Pty Ltd. | Biodegradable polymer—bioactive moiety conjugates |
WO2010040187A1 (en) | 2008-10-10 | 2010-04-15 | The Bionic Ear Institute | Polymer-bioactive agent conjugates |
EP2355853B1 (en) * | 2008-10-10 | 2016-12-07 | Polyactiva Pty Ltd | Biodegradable polymer - bioactive moiety conjugates |
US8680050B2 (en) | 2009-02-03 | 2014-03-25 | Amunix Operating Inc. | Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same |
BR122021021381B1 (pt) | 2009-02-03 | 2023-05-16 | Amunix Pharmaceuticals, Inc | Método de aprimoramento de uma propriedade de uma proteína biologicamente ativa |
US8703717B2 (en) | 2009-02-03 | 2014-04-22 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
US9849188B2 (en) | 2009-06-08 | 2017-12-26 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
US8841249B2 (en) | 2009-08-06 | 2014-09-23 | Novo Nordisk A/S | Growth hormones with prolonged in-vivo efficacy |
CN101831067A (zh) * | 2010-05-31 | 2010-09-15 | 王二新 | 聚乙二醇脂类缀合物及其在制备药物中的应用 |
EP2446898A1 (en) | 2010-09-30 | 2012-05-02 | Laboratorios Del. Dr. Esteve, S.A. | Use of growth hormone to enhance the immune response in immunosuppressed patients |
CN102367290B (zh) * | 2011-04-26 | 2013-05-08 | 厦门赛诺邦格生物科技有限公司 | 链官能化的多级支化聚乙二醇及其合成方法 |
WO2014110867A1 (zh) * | 2013-01-17 | 2014-07-24 | 厦门赛诺邦格生物科技有限公司 | 一种单一官能化的支化聚乙二醇及其修饰的生物相关物质 |
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WO1993000109A1 (en) * | 1991-06-28 | 1993-01-07 | Genentech, Inc. | Method of stimulating immune response using growth hormone |
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EP2305804B1 (en) * | 1999-01-14 | 2015-05-06 | Bolder Biotechnology, Inc. | MonoPEGylated human growth hormone |
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JP4412461B2 (ja) * | 2002-11-20 | 2010-02-10 | 日油株式会社 | 修飾された生体関連物質、その製造方法および中間体 |
EP1581260B1 (en) * | 2002-12-31 | 2014-09-17 | Nektar Therapeutics | Polymeric reagents comprising a ketone or a related functional group |
WO2005000360A2 (en) * | 2003-05-23 | 2005-01-06 | Nektar Therapeutics Al, Corporation | Peg derivatives having an amidocarbonate linkage |
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- 2005-08-25 AP AP2007003919A patent/AP2007003919A0/xx unknown
- 2005-08-25 CN CNA2005800291171A patent/CN101010105A/zh active Pending
- 2005-08-25 AU AU2005278903A patent/AU2005278903A1/en not_active Abandoned
- 2005-08-25 EP EP05784225A patent/EP1789092A2/en not_active Withdrawn
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- 2005-08-26 PE PE2005000991A patent/PE20060654A1/es not_active Application Discontinuation
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- 2005-08-29 UY UY29088A patent/UY29088A1/es not_active Application Discontinuation
- 2005-08-30 TW TW094129583A patent/TW200621291A/zh unknown
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- 2007-02-27 TN TNP2007000078A patent/TNSN07078A1/fr unknown
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TNSN07078A1 (fr) | 2008-06-02 |
CN101010105A (zh) | 2007-08-01 |
ECSP077281A (es) | 2007-03-29 |
MA28908B1 (fr) | 2007-10-01 |
AP2007003919A0 (en) | 2007-02-28 |
IL181085A0 (en) | 2007-07-04 |
MX2007002441A (es) | 2007-05-04 |
CA2577999A1 (en) | 2006-03-09 |
TW200621291A (en) | 2006-07-01 |
EP1789092A2 (en) | 2007-05-30 |
GT200500235A (es) | 2006-03-21 |
UY29088A1 (es) | 2006-03-31 |
NL1029828A1 (nl) | 2006-03-01 |
CR8942A (es) | 2007-08-16 |
ZA200701802B (en) | 2008-08-27 |
WO2006024953A2 (en) | 2006-03-09 |
JP2008511610A (ja) | 2008-04-17 |
NO20071322L (no) | 2007-05-29 |
BRPI0515118A (pt) | 2008-07-01 |
AU2005278903A1 (en) | 2006-03-09 |
AR050851A1 (es) | 2006-11-29 |
NL1029828C2 (nl) | 2006-10-20 |
PE20060654A1 (es) | 2006-08-12 |
WO2006024953A3 (en) | 2007-01-18 |
EA200700380A1 (ru) | 2007-10-26 |
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