KR20070034075A - 스트론튬과 비타민 ｄ를 함유하는 조성물 및 그의 용도 - Google Patents
스트론튬과 비타민 ｄ를 함유하는 조성물 및 그의 용도 Download PDFInfo
- Publication number
- KR20070034075A KR20070034075A KR1020077001916A KR20077001916A KR20070034075A KR 20070034075 A KR20070034075 A KR 20070034075A KR 1020077001916 A KR1020077001916 A KR 1020077001916A KR 20077001916 A KR20077001916 A KR 20077001916A KR 20070034075 A KR20070034075 A KR 20070034075A
- Authority
- KR
- South Korea
- Prior art keywords
- strontium
- medicament
- calcium
- pharmaceutical composition
- vitamin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 90
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 title claims abstract description 51
- 229930003316 Vitamin D Natural products 0.000 title claims abstract description 45
- 235000019166 vitamin D Nutrition 0.000 title claims abstract description 45
- 239000011710 vitamin D Substances 0.000 title claims abstract description 45
- 229940046008 vitamin d Drugs 0.000 title claims abstract description 45
- 229910052712 strontium Inorganic materials 0.000 title claims description 103
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 title claims description 100
- 150000003710 vitamin D derivatives Chemical class 0.000 title description 25
- 239000003814 drug Substances 0.000 claims abstract description 186
- 159000000008 strontium salts Chemical class 0.000 claims abstract description 69
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 51
- -1 vitamin D compound Chemical class 0.000 claims abstract description 49
- AHBGXTDRMVNFER-UHFFFAOYSA-L strontium dichloride Chemical class [Cl-].[Cl-].[Sr+2] AHBGXTDRMVNFER-UHFFFAOYSA-L 0.000 claims abstract description 42
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- 229910000018 strontium carbonate Inorganic materials 0.000 claims abstract description 41
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- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims abstract description 24
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- 238000000034 method Methods 0.000 claims description 56
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- 229940047908 strontium chloride hexahydrate Drugs 0.000 claims description 8
- AMGRXJSJSONEEG-UHFFFAOYSA-L strontium dichloride hexahydrate Chemical compound O.O.O.O.O.O.Cl[Sr]Cl AMGRXJSJSONEEG-UHFFFAOYSA-L 0.000 claims description 8
- 229910052917 strontium silicate Inorganic materials 0.000 claims description 8
- QSQXISIULMTHLV-UHFFFAOYSA-N strontium;dioxido(oxo)silane Chemical compound [Sr+2].[O-][Si]([O-])=O QSQXISIULMTHLV-UHFFFAOYSA-N 0.000 claims description 8
- DHEQXMRUPNDRPG-UHFFFAOYSA-N strontium nitrate Chemical compound [Sr+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O DHEQXMRUPNDRPG-UHFFFAOYSA-N 0.000 claims description 6
- UBXAKNTVXQMEAG-UHFFFAOYSA-L strontium sulfate Chemical compound [Sr+2].[O-]S([O-])(=O)=O UBXAKNTVXQMEAG-UHFFFAOYSA-L 0.000 claims description 6
- KQAGKTURZUKUCH-UHFFFAOYSA-L strontium oxalate Chemical compound [Sr+2].[O-]C(=O)C([O-])=O KQAGKTURZUKUCH-UHFFFAOYSA-L 0.000 claims description 3
- QRVYVKGHSWMAJI-IYEMJOQQSA-L strontium;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Sr+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O QRVYVKGHSWMAJI-IYEMJOQQSA-L 0.000 claims description 3
- VUWAXXIHYHUOJV-TYYBGVCCSA-L strontium;(e)-but-2-enedioate Chemical compound [Sr+2].[O-]C(=O)\C=C\C([O-])=O VUWAXXIHYHUOJV-TYYBGVCCSA-L 0.000 claims description 3
- VUWAXXIHYHUOJV-ODZAUARKSA-L strontium;(z)-but-2-enedioate Chemical compound [Sr+2].[O-]C(=O)\C=C/C([O-])=O VUWAXXIHYHUOJV-ODZAUARKSA-L 0.000 claims description 3
- CPKHHOBKIQHTLE-UHFFFAOYSA-L strontium;1,2,2-trimethylcyclopentane-1,3-dicarboxylate Chemical compound [Sr+2].CC1(C)C(C([O-])=O)CCC1(C)C([O-])=O CPKHHOBKIQHTLE-UHFFFAOYSA-L 0.000 claims description 3
- IUMOPUXDPFMEMV-UHFFFAOYSA-L strontium;2,3-dihydroxybutanedioate Chemical compound [Sr+2].[O-]C(=O)C(O)C(O)C([O-])=O IUMOPUXDPFMEMV-UHFFFAOYSA-L 0.000 claims description 3
- RZDNXOOMMJEAFR-UHFFFAOYSA-L strontium;2-hydroxybutanedioate Chemical compound [Sr+2].[O-]C(=O)C(O)CC([O-])=O RZDNXOOMMJEAFR-UHFFFAOYSA-L 0.000 claims description 3
- CCUZKVDGQHXAFK-UHFFFAOYSA-L strontium;2-hydroxypropanoate Chemical compound [Sr+2].CC(O)C([O-])=O.CC(O)C([O-])=O CCUZKVDGQHXAFK-UHFFFAOYSA-L 0.000 claims description 3
- CRLDSNGPLRRUQU-UHFFFAOYSA-L strontium;butanedioate Chemical compound [Sr+2].[O-]C(=O)CCC([O-])=O CRLDSNGPLRRUQU-UHFFFAOYSA-L 0.000 claims description 3
- USBIHMTWQAZQAG-UHFFFAOYSA-L strontium;ethanesulfonate Chemical compound [Sr+2].CCS([O-])(=O)=O.CCS([O-])(=O)=O USBIHMTWQAZQAG-UHFFFAOYSA-L 0.000 claims description 3
- JKBSENMNXXOMSO-UHFFFAOYSA-L strontium;methanesulfonate Chemical compound [Sr+2].CS([O-])(=O)=O.CS([O-])(=O)=O JKBSENMNXXOMSO-UHFFFAOYSA-L 0.000 claims description 3
- LVZZABGEQTZXHP-UHFFFAOYSA-L strontium;propanedioate Chemical compound [Sr+2].[O-]C(=O)CC([O-])=O LVZZABGEQTZXHP-UHFFFAOYSA-L 0.000 claims description 3
- QGAPCDHPGCYAKM-UHFFFAOYSA-H tristrontium;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Sr+2].[Sr+2].[Sr+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QGAPCDHPGCYAKM-UHFFFAOYSA-H 0.000 claims description 3
- JOPDZQBPOWAEHC-UHFFFAOYSA-H tristrontium;diphosphate Chemical compound [Sr+2].[Sr+2].[Sr+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O JOPDZQBPOWAEHC-UHFFFAOYSA-H 0.000 claims description 3
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- 230000000694 effects Effects 0.000 description 24
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Inorganic Chemistry (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
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| DKPA200400991 | 2004-06-25 | ||
| DKPA200400991 | 2004-06-25 | ||
| DKPA200401733 | 2004-11-10 | ||
| DKPA200401733 | 2004-11-10 | ||
| PCT/DK2005/000425 WO2006000224A2 (en) | 2004-06-25 | 2005-06-24 | Compositions comprising strontium and vitamin d and uses thereof |
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| KR20070034075A true KR20070034075A (ko) | 2007-03-27 |
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| KR1020077001916A Withdrawn KR20070034075A (ko) | 2004-06-25 | 2005-06-24 | 스트론튬과 비타민 ｄ를 함유하는 조성물 및 그의 용도 |
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|---|---|
| US (1) | US8658206B2 (https=) |
| EP (1) | EP1768748B2 (https=) |
| JP (2) | JP5070046B2 (https=) |
| KR (1) | KR20070034075A (https=) |
| AT (1) | ATE443541T1 (https=) |
| AU (1) | AU2005256317B2 (https=) |
| BR (1) | BRPI0512357A (https=) |
| CA (1) | CA2571449C (https=) |
| DE (1) | DE602005016803D1 (https=) |
| DK (1) | DK1768748T4 (https=) |
| EA (1) | EA011814B1 (https=) |
| IL (1) | IL180144A0 (https=) |
| MX (1) | MXPA06015187A (https=) |
| NO (1) | NO20070206L (https=) |
| WO (1) | WO2006000224A2 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080118603A1 (en) * | 2006-11-21 | 2008-05-22 | Lada Mark W | Nutritional beverage for optimal bone health |
| ES2395740T3 (es) * | 2006-11-21 | 2013-02-14 | Strontin Aps | Composiciones que comprenden estroncio y usos de las mismas en el tratamiento o prevención de la gingivitis, la periodontitis, la periodontitis como una manifestacioón de enfermedades sistémicas y las enfermedades peridontales necrotizantes |
| ES2573327T3 (es) * | 2007-04-23 | 2016-06-07 | Baxter International Inc. | Composiciones de fibrina que contienen compuestos de estroncio |
| KR20100047869A (ko) * | 2007-07-19 | 2010-05-10 | 디에스엠 아이피 어셋츠 비.브이. | 친유성 헬스 성분의 정제화가능한 배합물 |
| CA2695504C (en) * | 2007-08-03 | 2017-05-30 | Nucitec S.A. De C.V. | Compositions and methods for treatment and prevention of osteoarthritis |
| EP2416756A2 (en) * | 2009-04-10 | 2012-02-15 | Mahmut Bilgic | Stable pharmaceutical compositions with high bioavailibility |
| FR2945748A1 (fr) * | 2009-05-20 | 2010-11-26 | Debregeas Et Associes Pharma | Medicament a base de calcium et de vitamine d. |
| FR2953139B1 (fr) * | 2009-11-27 | 2012-04-13 | Servier Lab | Composition pharmaceutique comprenant un sel de strontium, de la vitamine d et une cyclodextrine |
| WO2012006475A1 (en) * | 2010-07-07 | 2012-01-12 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| JP5823514B2 (ja) | 2010-07-07 | 2015-11-25 | アーデリクス，インコーポレーテッド | リン酸輸送を阻害する化合物及び方法 |
| WO2012006477A1 (en) | 2010-07-07 | 2012-01-12 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| EP2590655B1 (en) | 2010-07-07 | 2015-06-24 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| JP5827327B2 (ja) | 2010-07-07 | 2015-12-02 | アーデリクス，インコーポレーテッド | リン酸輸送を阻害する化合物及び方法 |
| AU2012212385B2 (en) * | 2011-02-02 | 2015-01-15 | Ent Technologies Pty Ltd | Compositions and methods for the treatment of nasal passages |
| EP2530068A1 (en) | 2011-05-31 | 2012-12-05 | Lacer, S.A. | New strontium salts, synthesis and use thereof in the treatment of osteoporosis |
| WO2014044756A1 (en) * | 2012-09-20 | 2014-03-27 | Mokwalo SA | Strontium as anti microbial compound |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3345265A (en) * | 1963-10-09 | 1967-10-03 | Kendall & Co | Multiple layer tablet with calcium salt central core separated from soluble fluoride outer coating |
| US3699221A (en) * | 1965-02-23 | 1972-10-17 | Murray L Schole | Dental preparations |
| US3988434A (en) * | 1972-08-07 | 1976-10-26 | Schole Murray L | Dental preparation |
| FR2633619B1 (fr) | 1988-06-29 | 1991-02-08 | Adir | Nouveau sel de strontium, son procede de preparation et les compositions pharmaceutiques le renfermant |
| FR2651497B1 (fr) | 1989-09-01 | 1991-10-25 | Adir | Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
| FR2658816A1 (fr) * | 1990-02-27 | 1991-08-30 | Adir | Nouveaux sels de metaux alcalinoterreux d'oxa-polyacides leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US5380530A (en) * | 1992-12-29 | 1995-01-10 | Whitehill Oral Technologies | Oral care composition coated gum |
| US5624906A (en) * | 1994-12-08 | 1997-04-29 | Lever Brothers Company, Division Of Conopco, Inc. | Oral hygiene compositions comprising heteroatom containing alkyl aldonamide compounds |
| FR2749759B1 (fr) * | 1996-06-17 | 1999-11-26 | Adir | Utilisation de sels de strontium pour l'obtention de compositions pharmaceutiques destinees au traitement de l'arthrose |
| CN1164603C (zh) | 2001-09-29 | 2004-09-01 | 南京化工大学 | 1，6－二磷酸果糖锶盐系列化合物及其制备方法和在医药中的应用 |
| FR2844797B1 (fr) | 2002-09-24 | 2004-10-22 | Servier Lab | Nouveau procede de synthese industriel des tetraesters de l'acide 5-[bis (carboxymethyl)]-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates |
| FR2844795B1 (fr) | 2002-09-24 | 2004-10-22 | Servier Lab | Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates |
| FR2844796A1 (fr) | 2002-09-24 | 2004-03-26 | Servier Lab | Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates |
| ES2394782T3 (es) | 2003-05-07 | 2013-02-05 | Osteologix A/S | Composición con estroncio y vitamina D para la profilaxis y/o tratamiento de afecciones de cartílagos y/o huesos |
| EP1622629B1 (en) * | 2003-05-07 | 2013-07-10 | Osteologix A/S | Controlled-release composition containing a strontium salt |
| EP1745791B1 (en) | 2003-05-07 | 2013-06-26 | Osteologix A/S | Treating cartilage/bone conditions with water-soluble strontium salts |
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2005
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- 2005-06-24 CA CA2571449A patent/CA2571449C/en not_active Expired - Fee Related
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- 2005-06-24 DE DE602005016803T patent/DE602005016803D1/de not_active Expired - Lifetime
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- 2005-06-24 MX MXPA06015187A patent/MXPA06015187A/es not_active Application Discontinuation
- 2005-06-24 JP JP2007516973A patent/JP5070046B2/ja not_active Expired - Fee Related
- 2005-06-24 US US11/570,767 patent/US8658206B2/en not_active Expired - Fee Related
- 2005-06-24 BR BRPI0512357-7A patent/BRPI0512357A/pt not_active IP Right Cessation
- 2005-06-24 AU AU2005256317A patent/AU2005256317B2/en not_active Ceased
- 2005-06-24 EP EP05750580.2A patent/EP1768748B2/en not_active Expired - Lifetime
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- 2006-12-18 IL IL180144A patent/IL180144A0/en unknown
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2007
- 2007-01-11 NO NO20070206A patent/NO20070206L/no not_active Application Discontinuation
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2012
- 2012-07-13 JP JP2012157477A patent/JP2012193208A/ja not_active Withdrawn
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| EP1768748B2 (en) | 2019-03-13 |
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| ATE443541T1 (de) | 2009-10-15 |
| IL180144A0 (en) | 2007-06-03 |
| EP1768748A2 (en) | 2007-04-04 |
| US8658206B2 (en) | 2014-02-25 |
| DK1768748T3 (da) | 2010-02-01 |
| DK1768748T4 (da) | 2019-06-11 |
| DE602005016803D1 (de) | 2009-11-05 |
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| EA011814B1 (ru) | 2009-06-30 |
| AU2005256317B2 (en) | 2011-09-15 |
| NO20070206L (no) | 2007-03-22 |
| EA200700130A1 (ru) | 2007-06-29 |
| MXPA06015187A (es) | 2007-09-27 |
| JP2012193208A (ja) | 2012-10-11 |
| JP2008503504A (ja) | 2008-02-07 |
| HK1102427A1 (en) | 2007-11-23 |
| BRPI0512357A (pt) | 2008-03-04 |
| CA2571449A1 (en) | 2006-01-05 |
| WO2006000224A2 (en) | 2006-01-05 |
| CA2571449C (en) | 2015-12-08 |
| WO2006000224A3 (en) | 2006-05-18 |
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