CN1164603C - 1,6-二磷酸果糖锶盐系列化合物及其制备方法和在医药中的应用 - Google Patents
1,6-二磷酸果糖锶盐系列化合物及其制备方法和在医药中的应用 Download PDFInfo
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- CN1164603C CN1164603C CNB011272864A CN01127286A CN1164603C CN 1164603 C CN1164603 C CN 1164603C CN B011272864 A CNB011272864 A CN B011272864A CN 01127286 A CN01127286 A CN 01127286A CN 1164603 C CN1164603 C CN 1164603C
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- strontium salt
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Abstract
Description
性别 | 组别 | 动物数(只) | 骨密度(g/cm2) |
雄性 | 正常对照组 | 3 | 0.218±0.002 |
维甲酸模型组 | 5 | 0.210±0.003△△ | |
式II化合物30mg/kg | 4 | 0.212±0.006 | |
式II化合物100mg/kg | 4 | 0.216±0.003* | |
式II化合物300mg/kg | 5 | 0.216±0.005* | |
式II化合物1000mg/kg | 6 | 0.227±0.01** | |
羟乙基磷酸钠50mg/kg | 4 | 0.209±0.006 | |
雌性 | 正常对照组 | 4 | 0.237±0.008 |
维甲酸模型组 | 6 | 0.217±0.009△△ | |
式II化合物30mg/kg | 5 | 0.223±0.011 | |
式II化合物100mg/kg | 6 | 0.226±0.006* | |
式II化合物300mg/kg | 5 | 0.230±0.011** | |
式II化合物1000mg/kg | 6 | 0.232±0.013* | |
羟乙基磷酸钠50mg/kg | 6 | 0.230±0.009* |
组别 | 剂量mg/kg | 血钙mmol/L | 血磷mmol/L | 骨钙Cag/100g灰分 |
正常对照组 | 2.27±0.24 | 3.15±0.34 | 38.22±0.52 | |
维甲酸模型组 | 1.96±0.17 | 3.29±0.28 | 36.16±1.46△△ | |
式II化合物 | 30 | 1.91±0.16 | 3.31±0.34 | 37.71±1.50 |
式II化合物 | 100 | 1.92±0.08 | 3.32±0.30 | 38.76±0.79** |
式II化合物 | 300 | 1.92±0.08 | 3.14±0.19 | 38.40±1.84* |
式II化合物 | 1000 | 1.99±0.35 | 3.34±0.29 | 38.84±0.49** |
羟乙基磷酸钠 | 50 | 1.94±0.08 | 2.99±0.08 | 38.52±0.51** |
样品 | 性别 | 动物数(只) | 体重变化(天) | ||||
0 | 3 | 6 | 10 | 14 | |||
式II化合物 | 雄 | 10 | 19.9±0.34 | 21.5±1.1 | 22.4±1.3 | 22.9±1.3 | 23.8±1.4 |
雌 | 10 | 19.9±0.19 | 21.4±1.3 | 23.2±1.5 | 23.9±1.5 | 25.3±1.9 | |
对照组 | 雄 | 10 | 19.6±0.45 | 21.1±0.75 | 22.5±0.64 | 23.4±0.55 | 24.3±0.40 |
雌 | 10 | 19.5±0.33 | 21.1±0.65 | 22.7±0.38 | 23.8±0.69 | 26.0±0.64 |
Claims (10)
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CNB011272864A CN1164603C (zh) | 2001-09-29 | 2001-09-29 | 1,6-二磷酸果糖锶盐系列化合物及其制备方法和在医药中的应用 |
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CNB011272864A CN1164603C (zh) | 2001-09-29 | 2001-09-29 | 1,6-二磷酸果糖锶盐系列化合物及其制备方法和在医药中的应用 |
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CN1164603C true CN1164603C (zh) | 2004-09-01 |
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CN101018586B (zh) * | 2004-06-25 | 2014-08-27 | 莫克瓦洛Spf有限公司 | 含锶和维生素d的组合物及其用途 |
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CN100457114C (zh) * | 2005-11-24 | 2009-02-04 | 南京工业大学 | 1,6-二磷酸果糖锶盐在制药中的应用 |
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