KR20060135945A - 염색체 안정화에 관한 유전자를 표적으로 하는 암세포 특이적 아포토시스 유도제 - Google Patents

염색체 안정화에 관한 유전자를 표적으로 하는 암세포 특이적 아포토시스 유도제 Download PDF

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KR20060135945A
KR20060135945A KR1020067023433A KR20067023433A KR20060135945A KR 20060135945 A KR20060135945 A KR 20060135945A KR 1020067023433 A KR1020067023433 A KR 1020067023433A KR 20067023433 A KR20067023433 A KR 20067023433A KR 20060135945 A KR20060135945 A KR 20060135945A
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모토키 다카기
가즈노부 후타미
아키라 시마모토
야스히로 후루이치
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Abstract

본 발명자들에 의해, 염색체의 안정화에 관련하는 여러 가지의 유전자에 대해서, 당해 유전자의 발현을 억제함으로써, 암세포 특이적으로 아포토시스가 유도되고, 세포증식의 억제가 일어나는 것이 명백하게 되었다. 염색체의 안정화에 관련하는 유전자의 발현 또는 당해 유전자에 의해 코드되는 단백질의 기능을 억제하는 화합물은, 암세포 특이적인 아포토시스 유도 효과를 갖는 것이라고 생각된다.

Description

염색체 안정화에 관한 유전자를 표적으로 하는 암세포 특이적 아포토시스 유도제{Carcinoma cell-specific apoptosis-inducing agent targeting gene relevant to chromosome stabilization}
본 발명은, 염색체의 안정화에 관여하는 유전자를 표적으로 하는 암세포 특이적 아포토시스 유도제 및 당해 아포토시스 유도제의 스크리닝 방법에 관한 것이다.
세포에 있어서는, 여러 가지의 기능(유전자)의 작용에 따라 염색체가 안정하게 유지되고 있다. 이 염색체의 안정화에 기여하는 세포에서의 대표적인 기능(유전자)으로서는, 예를 들어 이하와 같은 것을 들 수 있다.
(a) 인간 염색체 불안정성 질환 관련 유전자
인간 염색체 불안정성 질환의 환자 유래 세포에서는, 염색체의 절단·결실·전좌·이수화가 보이고, 또한 이들 질환의 환자 유래 세포는 DNA 손상을 일으키는 약제에 대해 감수성을 나타내는 등 염색체의 불안정화가 생기는 것으로부터, 인간 염색체 불안정성 질환 관련 유전자는 염색체 안정화에 관여하고 있다.
(b) 염색체 DNA의 복제 개시, 복제 포크(fork)의 진행을 포함하는 염색체 DNA 복제반응은 세포가 증식할 때, 염색체 DNA를 복제하는 역할을 맡고 있고, 1개 의 세포가 2개로 분열할 때에 정확하게 염색체를 2배로 복제하여 염색체 수를 유지하는 기능을 갖는다.
(c) DNA 손상 체크 포인트
DNA 손상 체크 포인트는, 세포주기가 G1기, S기, G2기, M기의 각 단계에서 다음 단계로 이행할 때, 염색체에 절단·화학수식·가교를 포함하는 DNA 손상을 체크하는 역할을 맡고 있고, 다음의 세포주기의 단계로 이행하기 전에 염색체상의 DNA 손상을 제거하는 기능을 갖는다.
(d) 자매 염색 분체 응집·분리
자매 염색 분체 응집·분리는, 체세포에 있어서 복제를 마친 자매 염색 분체를 낭세포에 정확하게 분리하는 역할을 맡고 있다.
(e) 염기 제거 수복
염기 제거 수복은, 염색체 DNA 중의 염기에 산화나 메틸화를 포함하는 화학수식 손상이 생긴 경우에 수식된 염기를 제거하는 역할을 맡고 있다.
(f) 미스매치 제거 수복
미스매치 제거 수복은, 염색체 DNA 중의 올바른 염기쌍 G-C와 A-T 이외의 미스매치 염기쌍을 인식하여 올바른 염기쌍에 수복하는 역할을 맡고 있다.
(g) 뉴클레오티드 제거 수복
뉴클레오티드 제거 수복은, 자외선 조사에 의해 염색체 DNA 중에 생기는 시클로부탄형 피리미딘 2량체나 6-4 광산물, 또한 시스플라틴에 의해 염색체 DNA 중의 인접한 염기의 사이에서 생기는 DNA 쇄 내 가교 등의 손상을 인식하여, 손상부 를 제거하여 수복하는 역할을 맡고 있다.
(h) 상동 재조합 수복
상동 재조합 수복은, 염기 제거 수복, 미스매치 제거 수복, 뉴클레오티드 제거 수복 등의 수복기구가 불완전하여 생긴 DNA 손상, 또한 염색체 DNA 중에 생긴 절단, 갭 등을 포함하는 여러 가지 DNA 손상을, 손상을 갖지 않는 상동 염색체를 주형으로 하여 수복하는 역할을 맡고 있다.
(i) 비상동 말단 결합 수복(비상동 재조합 수복)
비상동 말단 결합 수복(비상동 재조합 수복)은, 염색체 DNA 중에 생긴 이중쇄 절단의 말단을 결합하여 수복하는 역할을 맡고 있다.
(j) 이중쇄 DNA 절단 수복
이중쇄 DNA 절단 수복은, 염색체 DNA 중에 생긴 이중쇄 절단을 수복하는 역할을 맡고 있고, 상동 재조합 수복이나 비상동 말단 결합 수복(비상동 재조합 수복)이 이 수복기구에 포함된다.
(k) DNA 복제 후 수복(DNA 손상 내성)
DNA 복제 후 수복(DNA 손상 내성)은, 손상을 갖는 염색체 DNA가 복제되는 경우에, 손상이 존재하는 DNA쇄의 복제를 가능하게 하는 기구에서 남겨진 DNA 손상은 복제 후에 수복된다.
(l) DNA 가교 손상 수복
DNA 가교 손상 수복은, 시스플라틴 등의 가교제에 의해 생긴 염색체 내나 염색체 사이에서의 DNA 가교 손상을 수복하는 역할을 맡고 있다.
(m) DNA-단백질 가교 손상 수복
DNA-단백질 가교 손상 수복은, DNA 수복의 반응 중간체인 효소 단백질-DNA의 공유 결합체가 형성된 경우, 또한 염색체 DNA 중의 염기와 단백질의 가교결합이 형성된 경우에, 공유 결합체나 가교 결합체를 제거하는 역할을 맡고 있다.
(n) DNA 폴리머라아제
DNA 폴리머라아제는, 복제, 재조합, 수복 등의 염색체 안정화 기구에 있어서, DNA 합성반응을 행하는 역할을 맡고 있다.
(o) 뉴클레아제
뉴클레아제는, 복제, 재조합, 수복 등의 염색체 안정화 기구에 있어서, DNA 분해반응을 행하는 역할을 맡고 있다.
(p) 뉴클레오티드 정화
뉴클레오티드 정화는, DNA 합성반응의 기질이 되는 뉴클레오티드 중의 염기에 산화나 메틸화를 포함하는 화학 수식 손상이 생긴 경우에, 수식된 염기를 제거하는 역할을 맡고 있다.
(q) 염색질 구조 유지
염색질 구조 유지는, 염색체의 고차 구조를 개재한 복제, 재조합, 수복 등의 염색체 안정화 기구에 작동한다.
(r) 텔로미어 구조 유지
텔로미어 구조 유지는, 염색체 말단의 텔로미어 길이의 제어, 텔로미어 영역의 특수한 고차 구조의 형성·유지를 개재하여 염색체 안정화에 중요한 역할을 맡 고 있다.
또한, 상기 기능에 관련한 여러 가지의 유전자에 대해서, 염색체의 안정화에 관여하는 것이 보고되어 있다. 예를 들어, 염색체의 안정화에 관여하는 여러 가지의 유전자에 대해서, 여러 가지의 지견이 보고되어 있다(비특허문헌 1~83 참조).
그러나, 염색체의 안정화에 관여하는 상술한 기능(유전자)과 암세포 특이적인 아포토시스 유도의 관련은, 지금까지 알려져 있지 않았다.
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비특허문헌 2: Nyberg, K.A., Michelson, R.J., Putnam, C.W. and Weinert, T.A.(2002). Toward maintaining the genome: DNA damage and replication checkpoints Annu.Rev.Genet.36, 617-656.
비특허문헌 3: Sogo, J.M., Lopes, M. and Foiani, M.(2002). Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects Science, 297, 599-602.
비특허문헌 4: Casper, A.M., Ngheim, P., Arlt, M.F. and Glover, T.W.(2002). ATR regulates fragile site stability Cell, 111, 779-789.
비특허문헌 5: Zhou, B.-B.S. and Bartek, J.(2004). Targeting the checkpoint kinases: chemosensitization versus chemoprotection Nature Review, 4, 1-10.
비특허문헌 6: Rich, T., Allen, R. and Wyllie, A.H.(2000). Defying death after DNA damage Nature, 407, 777-783.
비특허문헌 7: Nigg, E.A.(2002). Centrosome aberrations: cause or consequence of cancer progression Nature Review, 2, 815-825.
비특허문헌 8: Miller, H. and Grollman, A.P.(2003). DNA repair investigations using siRNA DNA repair, 2, 759-763.
비특허문헌 9: Merchant, A.M., Kawasaki, Y., Chen, Y., Lei, M., Tye, B.K.(1997). A lesion in the DNA replication initiation factor Mcm10 induces pausing of elongation forks through chromosomal replication origins in Saccharomyces cerevisiae. Mol Cell Biol., 17, 3261-3271.
비특허문헌 10: Tugal, T., Zou-Yang, X.H., Gavin, K., Pappin, D., Canas, B., Kobayashi, R., Hunt, T. and Stillman, B.(1998). The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p J.Biol. Chem., 273, 32421-32429.
비특허문헌 11: Stoeber, K., Mills, A.D., Kubota, Y., Krude, T., Romanowski, P., Marheineke, K., Laskey, R.A. and Williams, G.(1998). Cdc6 protein causes premature entry into S phase in a mammalian cell-free system EMBO J., 17, 7219-7229.
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본 발명은, 암세포 특이적인 아포토시스 유도제의 제공을 과제로 한다. 보다 상세하게는, 염색체의 안정화를 저해하는 화합물, 염색체의 안정화에 관여하는 유전자의 발현을 저해하는 화합물, 또는, 당해 유전자에 의해 코드되는 단백질의 기능을 저해하는 화합물을 유효성분으로 하는 암세포 특이적 아포토시스 유도제 및 당해 아포토시스 유도제의 스크리닝 방법의 제공을 과제로 한다. 또, 아포토시스 유도제를 의약 조성물로서 제조하는 방법의 제공을 과제로 한다.
본 발명자들은 상기 과제를 해결하기 위해, 세포에 있어서 염색체의 안정화에 관련한 여러 가지의 기능에 대해서, 당해 기능의 이상에 따라 아포토시스가 암세포 특이적으로 유도되는지의 여부에 대한 검토를 행하였다. 세포에서의 염색체의 안정화에 관련한 기능으로서는, 염색체의 안정화에 깊게 관여하는 이하의 기능을 선택하였다. (a) 인간 염색체 불안정성 질환 관련 유전자, (b) 염색체 DNA의 복제 개시, 복제 포크의 진행을 포함하는 염색체 DNA 복제반응, (c) DNA 손상 체크 포인트, (d) 자매 염색분체 응집·분리, (e) 염기 제거 수복, (f) 미스매치 제거 수복, (g) 뉴클레오티드 제거 수복, (h) 상동 재조합 수복, (i) 비상동 말단 결합 수복(비상동 재조합 수복), (j) 이중쇄 DNA 절단 수복, (k) DNA 복제 후 수복(DNA 손상 내성), (l) DNA 가교 손상 수복, (m) DNA-단백질 가교 손상 수복, (n) DNA 폴리머라아제, (o) 뉴클레아제, (p) 뉴클레오티드 정화, (q) 염색질 구조 유지, (r) 텔로미어 구조 유지.
본 발명자들은, 상기 각종 기능에 관여하는 여러 가지의 유전자에 대해서, 당해 유전자의 발현 억제 효과를 갖는 siRNA를 이용하여 당해 유전자의 암세포에서의 아포토시스 유도효과를 검토하였다. 그 결과, 상기 각 기능에 관여하는 복수의 유전자에 대해서 그 발현을 억제함으로써, 암세포에 있어서 아포토시스가 유도되고, 세포증식의 억제를 일으키는 것을 발견하였다. 또, 본 발명자들은, 당해 유전자의 발현을 억제해도 정상 세포(야생형 세포)에 대해서는 아포토시스의 유도가 일어나지 않는 것을 처음으로 발견하였다. 당해 유전자는, 매우 우수한 부작용이 적은 항암제(제암제)의 타겟 분자라고 생각된다.
상술한 결과로부터, 상기 각종 기능에 관여하는 유전자의 발현을 억제함으로써, 아포토시스를 유도하는 것이 가능한 것이 나타났다. 또한, 당해 유전자는, 상기 각종 기능에 깊게 관여하고 있고, 통상, 당해 유전자의 발현이 억제됨으로써 상기 기능은 세포에 있어서 정상적으로 작동하지 않게 된다. 따라서, 본 발명자들에 의해 발견된 상기 지견은, 즉 상기 각종 기능의 이상에 따라 암세포 특이적으로 아포토시스가 유도되는 것을 나타내는 것이다. 따라서, 상기 각종 기능을 저해시키는 화합물은, 암세포 특이적인 아포토시스 유도작용을 갖는 것이라고 생각된다.
또, 상기 각종 기능의 이상에 의해, 염색체가 불안정화되는 것이 알려져 있다. 따라서, 세포에서의 염색체의 불안정화가 암세포 특이적인 아포토시스 유도의 계기가 되어 있는 것이 생각된다. 즉, 세포에서의 염색체 안정화를 저해하는 화합물, 혹은, 염색체 안정화에 관여하는 유전자의 기능을 저해하는 화합물은, 암세포 특이적인 아포토시스 유도제가 되는 것이 기대된다.
본 발명은, 염색체의 안정화를 저해하는 화합물, 염색체의 안정화에 관여하는 유전자의 발현을 저해하는 화합물, 또는, 당해 유전자에 의해 코드되는 단백질의 기능을 저해하는 화합물을 유효성분으로 하는 암세포 특이적 아포토시스 유도제 및 당해 아포토시스 유도제의 스크리닝 방법에 관하여, 보다 상세하게는,
〔1〕염색체의 안정화를 저해하는 화합물을 포함하는 암세포 특이적 아포토시스 유도제,
〔2〕염색체의 안정화의 저해가 이하의 (a)~(r)의 어느 하나의 기능을 저해하는 것에 의한 〔1〕에 기재된 아포토시스 유도제,
(a) 인간 염색체 불안정성 질환 관련 유전자
(b) 염색체 DNA의 복제 개시, 복제 포크의 진행을 포함하는 염색체 DNA 복제반응
(c) DNA 손상 체크 포인트
(d) 자매 염색분체 응집·분리
(e) 염기 제거 수복
(f) 미스매치 제거 수복
(g) 뉴클레오티드 제거 수복
(h) 상동 재조합 수복
(i) 비상동 말단 결합 수복(비상동 재조합 수복)
(j) 이중쇄 DNA 절단 수복
(k) DNA 복제 후 수복(DNA 손상 내성)
(l) DNA 가교 손상 수복
(m) DNA-단백질 가교 손상 수복
(n) DNA 폴리머라아제
(o) 뉴클레아제
(p) 뉴클레오티드 정화
(q) 염색질 구조 유지
(r) 텔로미어 구조 유지
〔3〕〔2〕의 (a)~(r)의 어느 하나의 기능에 관여하는 유전자의 발현을 저해하는 화합물을 포함하는 암세포 특이적 아포토시스 유도제,
〔4〕이하의 어느 하나에 기재된 유전자의 발현을 억제하는 화합물을 유효성분으로서 함유하는 암세포 특이적 아포토시스 유도제,
APE2, ATR, BRCA1, Chk1, Cdc5, Cdc6, Cdc7, Cdc45, Cdt1, CSA, CSB, Ctf18, DDB1, DDB2, DNA2, DUT, Elg1, EndoV, Esp1, Exonuclease1, FBH1, FEN1, Geminin, Hus1, KNTC2(NDC80), Ku80, Ligase1, Mad2, MBD4, Mcm3, Mcm4, Mcm5, Mcm6, Mcm7, Mcm8, Mcm10, MGMT, MLH3, Mms4, MPG, MSH2, Mus81, NBS1, NEIL2, NEIL3, NTH1, Orc1, Orc3, PARP1, PCNA, Pif1, PMS1, PMS2, PNK, Pola p180, Pola p70, Pola Spp1(Prim2a), Polb, Pold p125, Pole Dpb3, Pole Dpb4, Pole Pol2, Poli, Poll, Polm, Psf1, Psf2, Psf3, Rad1, Rad18, Rad23A, Rad23B, Rad51, Rad51D, Rad54, Rad6A, RPA34, RPA70, Scc1, Scc3, Sir2, SIRT1(Sirtuin), TDG, TDP1, TIMELESS, Tin2, Topoisomerase I, Topoisomerase IIIa, Topoisomerase IIIb, Ubc13, UNG, XAB2, XPC, XPF, XPG, Xrcc2, XRCC4
〔5〕〔4〕에 기재된 각 유전자의 염기배열이 배열번호: 1~637, 810~908에 기재된 염기배열로 이루어지는 군에서 선택되는 〔4〕에 기재된 아포토시스 유도제,
〔6〕〔4〕에 기재된 어느 하나의 유전자의 발현을 억제하는 화합물이 당해 유전자에 대해 RNAi 효과를 갖는 이중쇄 RNA(siRNA)인 〔4〕에 기재된 아포토시스 유도제,
〔7〕이중쇄 RNA가 〔4〕에 기재된 어느 하나의 유전자의 mRNA에서의 연속하는 임의의 20~30 염기와 상동인 배열로 이루어지는 센스 RNA 및 당해 센스 RNA에 상보적인 배열로 이루어지는 안티센스 RNA로 이루어지는 이중쇄 RNA인 〔6〕에 기재된 아포토시스 유도제,
〔7b〕RNAi 효과를 갖는 이중쇄 RNA가, 당해 이중쇄의 한쪽의 쇄가 배열번호: 724~809(단, 당해 배열에 있어서, 말단의 TT를 제외한 영역이 이중쇄의 한쪽의 쇄를 구성한다), 또는 974~1063의 어느 하나에 기재된 염기배열이고, 다른 쪽의 쇄가 당해 염기배열과 상보적인 염기배열인 것을 특징으로 하는 이중쇄 RNA인 〔6〕에 기재된 아포토시스 유도제,
〔7c〕RNAi 효과를 갖는 이중쇄 RNA가, 당해 이중쇄의 한쪽의 쇄가 배열번호: 724~809(단, 당해 배열에 있어서, 말단의 TT를 제외한 영역이 이중쇄의 한쪽의 쇄를 구성한다), 또는 974~1063의 어느 하나에 기재된 염기배열에 있어서 1 또는 소수의 염기가 부가, 결실, 치환된 염기배열이고, 다른 쪽의 쇄가 당해 염기배열과 상보적인 염기배열인 것을 특징으로 하는 이중쇄 RNA로서, 상기 〔4〕에 기재된 어느 하나의 유전자의 발현을 억제하는 기능을 갖는 이중쇄 RNA인 〔6〕에 기재된 아포토시스 유도제,
〔7d〕상기 이중쇄 RNA의 한쪽의 말단이 닫힌 구조인(헤어핀을 형성하는) 분자를 유효성분으로서 함유하는 암세포 특이적 아포토시스 유도제,
〔8〕〔4〕에 기재된 어느 하나의 유전자에 대해 RNAi 효과를 갖는 이중쇄 RNA를 발현할 수 있는 DNA를 유효성분으로서 함유하는 암세포 특이적 아포토시스 유도제,
〔9〕〔4〕에 기재된 어느 하나의 유전자의 발현을 억제하는 화합물이 이하의 (a) 또는 (b)인 〔4〕에 기재된 아포토시스 유도제,
(a) 상기 유전자의 전사 산물 또는 그 일부에 대한 안티센스 핵산
(b) 상기 유전자의 전사 산물을 특이적으로 개열(開裂)하는 리보자임 활성을 갖는 핵산
〔10〕〔4〕에 기재된 어느 하나의 유전자에 의해 코드되는 단백질의 기능을 억제하는 화합물을 유효성분으로서 함유하는 암세포 특이적 아포토시스 유도제,
〔11〕〔4〕에 기재된 어느 하나의 유전자에 의해 코드되는 단백질의 기능을 억제하는 화합물이 이하의 (a)~(c)의 어느 하나의 화합물인 〔10〕에 기재된 아포토시스 유도제,
(a) 상기 유전자에 의해 코드되는 단백질에 대해 우성 음성(dominant negative)의 성질을 갖는 변이체 단백질
(b) 상기 유전자에 의해 코드되는 단백질에 결합하는 항체
(c) 상기 유전자에 의해 코드되는 단백질에 결합하는 저분자 화합물
〔12〕〔1〕~〔11〕의 어느 하나에 기재된 아포토시스 유도제를 유효성분으로 하는 항암제,
〔13〕이하의 (a)~(c)의 공정을 포함하는 암세포 특이적 아포토시스 유도제의 스크리닝 방법,
(a)〔4〕에 기재된 어느 하나의 유전자에 의해 코드되는 단백질 또는 그 부분 펩티드와 시험 화합물을 접촉시키는 공정
(b) 상기 단백질 또는 그 부분 펩티드와 시험 화합물의 결합 활성을 측정하는 공정
(c) 상기 유전자에 의해 코드되는 단백질 또는 그 부분 펩티드와 결합하는 화합물을 선택하는 공정
〔14〕이하의 (a)~(c)의 공정을 포함하는 암세포 특이적 아포토시스 유도제의 스크리닝 방법,
(a)〔4〕에 기재된 어느 하나의 유전자를 발현하는 세포 또는 세포 추출액과 시험 화합물을 접촉시키는 공정
(b) 상기 유전자의 발현 수준을 측정하는 공정
(c) 시험 화합물의 비존재하에 있어서 측정한 경우와 비교하여, 당해 발현 수준을 저하시키는 화합물을 선택하는 공정
〔15〕이하의 (a)~(c)의 공정을 포함하는 암세포 특이적 아포토시스 유도제의 스크리닝 방법,
(a)〔4〕에 기재된 어느 하나의 유전자의 전사 조절 영역과 리포터 유전자가 기능적으로 결합한 구조를 갖는 DNA를 포함하는 세포 또는 세포 추출액과 시험 화합물을 접촉시키는 공정
(b) 상기 리포터 유전자의 발현 수준을 측정하는 공정
(c) 시험 화합물의 비존재하에 있어서 측정한 경우와 비교하여, 상기 발현 수준을 저하시키는 화합물을 선택하는 공정
〔16〕이하의 (a)~(c)의 공정을 포함하는 암세포 특이적 아포토시스 유도제의 스크리닝 방법,
(a)〔4〕에 기재된 어느 하나의 유전자에 의해 코드되는 단백질, 또는 당해 단백질을 발현하는 세포 또는 세포 추출액과 시험 화합물을 접촉시키는 공정
(b) 상기 단백질의 활성을 측정하는 공정
(c) 시험 화합물의 비존재하에 있어서 측정한 경우와 비교하여, 상기 단백질의 활성을 저하시키는 화합물을 선택하는 공정
〔17〕이하의 공정 (a) 및 (b)를 포함하는 〔4〕 또는 〔10〕에 기재된 아포토시스 유도제를 의약 조성물로서 제조하는 방법,
(a)〔13〕~〔16〕의 어느 하나에 기재된 방법에 의해 화합물을 스크리닝하는 공정
(b) 당해 화합물을 약학상 허용되는 담체와 혼합하는 공정을 제공하는 것이다.
또한, 본 발명의 구체적인 일태양에 있어서는, 배열번호: 724~809, 974~1063의 어느 하나에 기재된 염기배열을 당해 이중쇄 RNA의 한쪽의 쇄로 하는 siRNA 분자(배열번호: 724~809, 974~1063의 어느 하나에 기재된 염기배열과, 그 상보쇄로 이루어지는 siRNA 분자)를 유효성분으로서 포함하는 암세포 특이적 아포토시스 유도제,
〔18〕대상 세포에 상기 어느 하나의 아포토시스 유도제를 투여하는(접촉시키는) 공정을 포함하는 당해 세포의 아포토시스를 유도하는 방법,
〔19〕상기 아포토시스 유도제 또는 상기 항암제를 개체(암환자 등)에 투여하는 공정을 포함하는 암의 치료방법,
〔20〕염색체의 안정화를 저해하는 화합물(예를 들어, 상기 〔4〕에 기재된 어느 하나의 유전자의 발현, 또는 당해 유전자에 의해 코드되는 단백질의 기능을 억제하는 화합물)의 아포토시스 유도제의 제조에서의 사용,
〔21〕상기 아포토시스 유도제의 항암제의 제조에서의 사용
을 제공한다.
본 발명자들에 의해, 세포에서의 염색체의 안정화를 저해함으로써, 암세포(종양세포)에 있어서 특이적으로 아포토시스가 유도되는 것이 발견되었다.
본 발명은 우선, 염색체의 안정화를 저해하는 화합물을 포함하는 암세포 특이적(암세포에 대한) 아포토시스 유도제를 제공한다.
본 발명의 아포토시스 유도제는, 암세포에 대해 선택적으로 아포토시스 유도작용을 갖는 것을 특징으로 하는 것이다. 본 발명에 있어서 「암세포 특이적」이란, 정상세포에 대해서는 실질적인 아포토시스 유도작용을 나타내지 않고, 암세포에 대해 실질적으로 아포토시스 유도작용을 나타내는 것을 말하는데, 바람직하게는, 정상세포에 대해서는 아포토시스 유도작용이 보이지 않고, 암세포에 대해 아포토시스 유도작용을 갖는 것을 말한다.
아포토시스란, 일반적으로 생리적 조건하에서 세포가 스스로 적극적으로 일으키는 세포죽음을 말한다. 아포토시스의 형태로서는, 예를 들어 세포 핵의 염색체 응집, 세포 핵의 단편화, 세포 표층 미세융모의 소실, 세포질의 응집 등을 들 수 있다. 따라서, 본 발명에서의 아포토시스 유도작용이란, 예를 들어 세포에 있어서 상기 아포토시스의 형태를 유도하는 작용을 가리키는데, 반드시 상기 형태의 유도에만 한정되는 것은 아니다. 당업자에 있어서는, 세포의 아포토시스 유도가 일어나고 있는지의 여부에 대해서 적절히 판단하는 것이 가능하다.
본 발명의 암세포 특이적 아포토시스 유도제는, 예를 들어 아포토시스 유도작용을 기능 기작으로 하는 항암제(제암제)가 되는 것이라고 생각된다. 본 발명의 아포토시스 유도제는, 암세포 특이적으로 아포토시스를 유도하고, 정상세포에는 아포토시스가 유도되지 않기 때문에 부작용이 적은 안전한 항암제가 되는 것으로 기대된다.
또, 본 발명에서의 「항암제」는 제암제로 표기하는 것도 가능하다. 또한, 상기 「항암제」는, 「항종양제」, 「항종양 약제」 또는 「항종양 의약 조성물」 등으로 표현되는 경우도 있다.
본 발명에 있어서 「염색체의 안정화가 저해된다」란, 예를 들어 염색체 DNA 중에 수복되지 않고 남은 손상이 축적한 상태가 되는 것 등을 가리키고, 구체적으로는, 염색체 DNA 중에 1개 쇄가 노출한 영역이 축적하거나, 이중쇄 DNA절단부분이 다수 출현하는 상태를 가리키는데, 반드시 이러한 상태에 한정되지 않는다.
본 발명에서의 「염색체의 안정화」는, 예를 들어 세포에서의 이하의 기능에 의해 유지되어 있다. 따라서, 이하의 기능을 저해함으로써, 염색체의 안정화가 저해된다.
(a) 인간 염색체 불안정성 질환 관련 유전자
(b) 염색체 DNA의 복제 개시, 복제 포크의 진행을 포함하는 염색체 DNA 복제반응
(c) DNA 손상 체크 포인트
(d) 자매 염색분체 응집·분리
(e) 염기 제거 수복
(f) 미스매치 제거 수복
(g) 뉴클레오티드 제거 수복
(h) 상동 재조합 수복
(i) 비상동 말단 결합 수복(비상동 재조합 수복)
(j) 이중쇄 DNA 절단 수복
(k) DNA 복제 후 수복(DNA 손상 내성)
(l) DNA 가교 손상 수복
(m) DNA-단백질 가교 손상 수복
(n) DNA 폴리머라아제
(o) 뉴클레아제
(p) 뉴클레오티드 정화
(q) 염색질 구조 유지
(r) 텔로미어 구조 유지
본 발명의 바람직한 태양에 있어서, 염색체의 안정화 저해란, 예를 들어 상기 (a)~(r)의 어느 하나의 기능을 저해하는 것을 들 수 있다.
즉, 본 발명의 바람직한 태양에 있어서는, 상기 (a)~(r)의 어느 하나의 기능을 저해하는 화합물을 포함하는 암세포 특이적 아포토시스 유도제에 관한 것이다.
본 발명에 있어서, 상기 (a)~(r)의 어느 하나의 기능을 저해하기 위해서는, 예를 들어 당해 기능에 관여하는 유전자(본 명세서에 있어서는, 「염색체 안정화 관련 유전자」라고 기재하는 경우가 있음)의 발현을 저해하거나, 또는 당해 유전자에 의해 코드되는 단백질의 기능(활성)을 저해하는 것을 들 수 있다.
상기 각 기능에 관여하는 유전자로서는, 예를 들어 이하의 유전자를 들 수 있는데, 상기 각 기능에 관여하는 유전자이면 특히 제한되지 않는다.
(a) 인간 염색체 불안정성 질환 관련 유전자
인간 염색체 불안정성 질환으로서는, 예를 들어 색소성 건피증, 코케인(cockayne)증, 네이미겐(nijmegen breakage)증, 혈관 확장성 실조증, 판코니 빈혈증 혹은 조노증 등을 들 수 있다. 이들 각 질환에 관련한 유전자를 이하에 기재한다.
·색소성 건피증: (a1)XPB, (a2)XPD, (a3)XPG, (a4)XPF, (a5)XPC, (a6)RAD23B, (a7)CETN2, (a8)RAD23A, (a9)ERCC1
·코케인증: (a10)CSA, (a11)CSB, (a12)XAB
·네이미겐증: (a13)NBS1
·혈관 확장성 실조증: (a14)ATM
·판코니 빈혈증: (a15)FANCA, (a16)FANCC, (a17)FANCD2, (a18)FANCE, (a19)FANCF, (a20)FANCG
·조노증: (a21)WRN, (a22)BLM, (a23)RTS
(b) 염색체 DNA의 복제 개시, 복제 포크의 진행을 포함하는 염색체 DNA 복제반응
(b1) Mcm10, (b2)Orc1, (b3)Orc3, (b4)Cdc6, (b5)Cdt1, (b6)Geminin, (b7)Mcm3, (b8)Mcm4, (b9)Mcm5, (b10)Mcm6, (b11)Mcm7, (b12)Mcm8, (b13)Cdc7, (b14)Cdc5, (b15)Psf1, (b16)Psf2, (b17)Psf3, (b18)Cdc45, (b19)Pola p180, (b20)Pola p70, (b21)Pola Spp1(Prim2a), (b22)RPA70, (b23)RPA34, (b24)PCNA, (b25)Elg1, (b26)Ligase1, (b27)Pole Pol2, (b28)Pole Dpb3, (b29)Topoisomerase I, (b30)TDP1, (b31)Orc2, (b32)Orc4, (b33)Orc5, (b34)Orc6, (b35)Mcm2, (b36)Dbf4, (b37)TopBP1, (b38)Sld5, (b39)Pola Spp2, (b40)RFC1, (b41)RFC2, (b42)RFC3, (b43)RFC4, (b44)RFC5, (b45)Pif1, (b46)Pold p50, (b47)Pole Dpb2, (b48)Topoisomerase Iia, (b49)Topoisomerase Iib, (b50)RPA14, (b51)FEN1, (b52)DNA2, (b53)Pold p125, (b54)Pold p68, (b55)Pold p12, (b56)Pole Dpb4
(c) DNA 손상 체크 포인트
(c1)ATR, (c2)Chk1, (c3)NBS1, (c4)Hus1, (c5)Rad1, (c11)Mad2, (c12)BubR1, (c12)ATM, (c13)Rad50, (c14)Mre11, (c15)Mdc1, (c16)53BP1, (c17)Rad17, (c22)BubR1, (c23)ATRIP, (c24)Chk2, (c25)H2AX, (c26)RFC1, (c27)RFC2, (c28)RFC3, (c29)RFC4, (c30)RFC5, (c31)ATM, (c32)BRCA1, (c33)Chk1, (c34)Chk2, (c35)14-3-3eta, (c36)14-3-3sigma, (c37)cdc25A, (c38)cdc25c, (c39)wee1, (c40)ATR, (c41)ATRIP, (c42)Rad17, (c43)RFC2, (c44)RFC3, (c45)RFC4, (c46)RFC5, (c47)HUS1, (c48)Rad1, (c49)Rad9, (c50)P53, (c51)Rad50, (c52)Mre11, (c53)NBS1, (c54)TopBP1, (c55)53BP1, (c56)H2AX
(d) 자매 염색분체 응집·분리
(d1)Ctf18, (d2)Scc1, (d3)Scc3, (d4)Dcc1, (d5)Trf4-1, (d6)Trf4-2, (d7)Smc1, (d8)Smc3, (d9)Pds1(Securin), (d10)Mad2, (d11)BubR1, (d12)Esp1
(e) 염기 제거 수복
(e1)UNG, (e2)MBD4, (e3)TDG, (e4)NTH1, (e5)NEIL2, (e6)NEIL3, (e7)APE2, (e8)PARP1, (e9)PNK, (e10)Polb, (e11)OGG1, (e12)APE1, (e13)XRCC1, (e14)Ligase3, (e15)SMUG1, (e16)TDG, (e17)MYH, (e18)MPG, (e19)NEIL1, (e20)ADPRT, (e21)ADPRTL2, (e22)MGMT, (e23)ABH1, (e24)ABH2, (e25)ABH3
(f) 미스매치 제거 수복
(f1)MSH2, (f2)PMS1, (f3)PMS2, (f4)MLH3, (f5)Exonuclease1, (f6)MSH3, (f7)MSH6, (f8)MSH5, (f9)MLH1, (f10)MSH4, (f11)PMS2L3, (f12)Trex1, (f13)Trex2, (f14)PMS2L4
(g) 뉴클레오티드 제거 수복
(g1)XPC, (g2)Rad23A, (g3)Rad23B, (g4)CSA, (g5)CSB, (g6)XPG, (g7)XPF, (g8)DDB1, (g9)DDB2, (g10)XAB2, (g11)XPB, (g12)ERCC1, (g13)XPD, (g14)XPA, (g15)DDB2, (g16)Mms19, (g17)CETN2, (g18)RPA70, (g19)RPA34, (g20)RPA14, (g21)GTF2H1, (g22)GTF2H2, (g23)GTF2H3, (g24)GTF2H4, (g25)CDK7, (g26)CCNH, (g27)MNAT1, (g28)LigaseI, (g29)CSA, (g30)CSB
(h) 상동 재조합 수복
(h1)Rad51, (h2)Rad51L1, (h3)Rad51C, (h4)Rad51L3, (h5)DMC1, (h6)XRCC2, (h7)XRCC3, (h8)Rad52, (h9)Rad54L, (h10)Rad54B, (h11)BRCA1, (h12)BRCA2, (h13)Rad50, (h14)Mre11, (h15)NBS1, (h16)TopoisomeraseIIIa, (h17)TopoisomeraseIIIb, (h18)WHIP, (h19)WRN, (h20)BLM, (h21)RecQ1, (h22)RecQ5
(i) 비상동 말단 결합 수복(비상동 재조합 수복)
(i1)Ku70, (i2)Ku80, (i3)DNA-pk, (i4)Ligase4, (i5)XRCC4, (i6)Artemis, (i7)WRN
(j) 이중쇄 DNA절단 수복
(j1)Rad51, (j2)Rad51D, (j3)Xrcc2, (j4)Rad54, (j5)BRCA1, (j6)Ku80, (j7)XRCC4, (j8)Rad52, (j9)Rad51C, (j10)Dmc1, (j11)Rad54B, (j12)DNA-pk, (j13)Ku70, (j14)Ligase4, (j15)Rad51B, (j16)XRCC3, (j17)BRCA2, (j18)Artemis
(k) DNA 복제 후 수복(DNA 손상 내성)
(k1)Rad6A, (k2)Rad6B, (k3)Rad18, (k4)Ubc13, (k5)FBH1
(l) DNA 가교 손상 수복
(l1)FANCA, (l2)FANCC, (l3)FANCD2, (l4)FANCE, (l5)FANCF, (l6)FANCG
(m) DNA-단백질 가교 손상 수복
(m1)TDP1
(n) DNA폴리머라아제
(n1)Poli, (n2)Polh, (n3)Polq, (n4)Polk, (n5)Polz(REV3), (n6)Poll, (n7)Polm, (n8)Rev1, (n9)Polb, (n10)Polg, (n11)Pold p50, (n12)Pole Pol2, (n13)REV7, (n14)Poln, (n15)Pola P180, (n16)Pola p70, (n17)Pola Spp1, (n18)Pola Spp2, (n19)Pold p68, (n20)Pold p12, (n21)Pole Dpb2, (n22)Pole Dpb3, (n23)Pole Dpb4
(o) 뉴클레아제
(o1)FEN1, (o2)TREX1, (o3)TREX2, (o4)Exonuclease1, (o5)SPO11, (o6)ENDO V, (o7)APE1, (o8)APE2, (o9)Mre11, (o10)Artemis
(p) 뉴클레오티드 정화
(p1)MTH1, (p2)DUT, (p3)p53R2
(q) 염색질 구조 유지
(q1)H2AX, (q2)Sir2, (q3)SIRT1(Sirtuin)
(r) 텔로미어 구조 유지
(r1)Tin2, (r2)Sir2, (r3)hTert, (r4)TRF1, (r5)TRF2, (r6)Tankyrase, (r7)Pot1, (r8)Rap1, (r9)Pif1
상기 (a)~(r)의 각 기능에 관여하는 유전자로서는, 바람직하게는, 후술하는 실시예에 기재된 유전자를 매우 적합하게 나타낼 수 있다. 구체적으로는, 이하에 기재된 유전자를 들 수 있다.
APE2, ATR, BRCA1, Chk1, Cdc5, Cdc6, Cdc7, Cdc45, Cdt1, CSA, CSB, Ctf18, DDB1, DDB2, DNA2, DUT, Elg1, EndoV, Esp1, Exonuclease1, FBH1, FEN1, Geminin, Hus1, KNTC2(NDC80), Ku80, Ligase1, Mad2, MBD4, Mcm3, Mcm4, Mcm5, Mcm6, Mcm7, Mcm8, Mcm10, MGMT, MLH3, Mms4, MPG, MSH2, Mus81, NBS1, NEIL2, NEIL3, NTH1, Orc1, Orc3, PARP1, PCNA, Pif1, PMS1, PMS2, PNK, Pola p180, Pola p70, Pola Spp1(Prim2a), Polb, Pold p125, Pole Dpb3, Pole Dpb4, Pole Pol2, Poli, Poll, Polm, Psf1, Psf2, Psf3, Rad1, Rad18, Rad23A, Rad23B, Rad51, Rad51D, Rad54, Rad6A, RPA34, RPA70, Scc1, Scc3, Sir2, SIRT1(Sirtuin), TDG, TDP1, TIMELESS, Tin2, Topoisomerase I, Topoisomerase IIIa, Topoisomerase IIIb, Ubc13, UNG, XAB2, XPC, XPF, XPG, Xrcc2, XRCC4
본 발명의 바람직한 태양에 있어서는, 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)의 발현, 또는, 당해 유전자에 의해 코드되는 단백질의 기능을 억제하는 화합물을 유효성분으로서 함유하는 암세포 특이적 아포토시스 유도제를 제공한다.
본 명세서에 있어서 기재된 유전자명은, 널리 일반적으로 알려진 명칭인 것으로부터, 당업자이면, 당해 유전자의 염기배열에 대한 정보를 유전자명을 기초로 공공의 문헌 데이터베이스 혹은 유전자 데이터베이스(예를 들어, GenBank 등)로부터 적절히 취득할 수 있다.
본 발명의 상기 어느 하나에 기재된 각 유전자의 염기배열 및 당해 유전자에 의해 코드되는 단백질의 아미노산 배열의 구체예를 배열표에 게재한다. 상기 유전자의 배열정보가 취득 가능한 NCBI의 액세션 번호 및 당해 번호에 의해 취득되는 유전자의 염기배열의 배열번호와의 관계를 표 1~16에 나타낸다. 또한, 본 발명의 상기 각 유전자에 의해 코드되는 단백질의 아미노산 배열의 일례에 대해서도, 배열표에 나타낸다.
Figure 112006081847963-PCT00001
Figure 112006081847963-PCT00002
Figure 112006081847963-PCT00003
Figure 112006081847963-PCT00004
Figure 112006081847963-PCT00005
Figure 112006081847963-PCT00006
Figure 112006081847963-PCT00007
Figure 112006081847963-PCT00008
Figure 112006081847963-PCT00009
Figure 112006081847963-PCT00010
Figure 112006081847963-PCT00011
Figure 112006081847963-PCT00012
Figure 112006081847963-PCT00013
Figure 112006081847963-PCT00014
Figure 112006081847963-PCT00015
Figure 112006081847963-PCT00016
또, 상기에 기재된 각 유전자는, 염기배열 중의 다형의 유무 등에 의해, 동일한 유전자이어도 복수의 액세션 번호가 부여되어 있는 경우가 있다. 이 「다형」이란, 일염기의 치환, 결실, 삽입 변이로 이루어지는 일염기다형(SNP)에 한정되지 않고, 연속하는 수염기의 치환, 결실, 삽입 변이도 포함된다. 따라서, 상기 각 유전자의 염기배열로서는, 반드시 표 1~표 16에 기재된 액세션 번호에 의해 취득되는 배열 혹은 배열번호:1~637, 810~908에 기재된 배열에 한정되지 않는다. 마찬가지로, 상기 각 유전자에 의해 코드되는 단백질의 아미노산 배열도, 배열번호:638~723, 909~973에 기재된 아미노산 배열에 특히 한정되지 않는다.
본 발명의 상기 단백질은, 배열번호:638~723, 909~973에 기재된 아미노산 배열에 한정되지 않고, 당해 아미노산 배열에 있어서, 1 또는 복수의 아미노산 잔기가 부가, 결실, 치환, 삽입된 아미노산 배열로 이루어지는 단백질로서, 배열번호:638~723, 909~973에 기재된 단백질과 기능적으로 동등한 단백질이 포함된다.
또한, 본 발명의 염색체 안정화 관련 유전자(예를 들어, 상기 각 유전자)는 특히 제한되는 것은 아니지만, 통상 동물 유래이고, 보다 바람직하게는 포유동물 유래이며, 가장 바람직하게는 인간 유래이다.
즉, 본 발명은 인간의 암세포에 대한 특이적인 아포토시스 유도제에 한정되지 않고, 인간 이외의 동물의 암세포에 대한 아포토시스 유도제도 본 발명에 포함된다. 따라서, 본 발명의 유전자에는, 상기 각 유전자에 대한 인간 이외의 동물에서의 동족체(카운터 파트) 유전자가 포함된다. 예를 들어, 배열번호:1~637, 810~908에 기재된 각 염기배열로 이루어지는 유전자에 대응하는 다른 동물에서의 내재성의 유전자(동족체 등)가 포함된다. 당해 염기배열로 이루어지는 DNA에 대응하는 다른 동물의 내재성의 DNA는, 일반적으로 당해 배열번호에 기재된 DNA와 높은 상동성을 갖는다. 높은 상동성이란, 50% 이상, 바람직하게는 70% 이상, 더 바람직하게는 80% 이상, 보다 바람직하게는 90% 이상(예를 들어 95% 이상, 더 96%, 97%, 98% 또는 99% 이상)의 상동성을 의미한다. 이 상동성은, mBLAST 알고리즘(Altschul et al.(1990) Proc. Natl. Acad. Sci. USA 87: 2264-8; Karlin and Altschul(1993) Proc. Natl. Acad. Sci. USA 90: 5873-7)에 의해 결정할 수 있다. 또한, 당해 DNA는, 생체 내로부터 분리한 경우, 당해 배열번호에 기재된 DNA와 스트린전트 조건하에서 하이브리다이즈한다고 생각된다. 여기서, 「스트린전트 조건」으로서는, 예를 들어 [2×SSC, 0.1% SDS, 50℃」, [2×SSC, 0.1% SDS, 42℃」, 「1×SSC, 0.1% SDS, 37℃」, 보다 스트린전트 조건으로서 [2×SSC, 0.1% SDS, 65℃」, 「0.5×SSC, 0.1% SDS, 42℃」 및 「0.2×SSC, 0.1% SDS, 65℃」의 조건을 들 수 있다. 당업자에 있어서는, 다른 동물에서의 본 발명의 상기 각 유전자에 상당하는 내재성 유전자에 관한 정보(배열 등)에 대해서, 배열표에 게재된 염기배열을 기초로 적절히 취득하는 것이 가능하다.
또한, 본 발명은, 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)의 발현을 억제하는 화합물을 제공한다.
본 발명의 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)의 발현을 억제하는 화합물로서는, 예를 들어 당해 유전자에 대해 RNAi(RNA interferance; RNA 간섭)효과를 갖는 이중쇄 RNA를 매우 적합하게 들 수 있다. 일반적으로 RNAi란, 표적 유전자의 mRNA 배열과 상동인 배열로 이루어지는 센스 RNA 및 이것과 상보적인 배열로 이루어지는 안티센스 RNA로 이루어지는 이중쇄 RNA를 세포 내에 도입함으로써, 표적 유전자 mRNA의 파괴를 유도하고, 표적 유전자의 발현이 저해되는 현상을 말한다.
RNAi 기구의 상세에 대해서는 아직 불명한 부분도 있지만, DICER라고 하는 효소(RNase III 핵산분해효소 패밀리의 일종)가 이중쇄 RNA와 접촉하고, 이중쇄 RNA가 small interfering RNA 또는 siRNA라고 불리는 작은 단편으로 분해되는 것이라고 생각되고 있다. 본 발명에서의 RNAi 효과를 갖는 이중쇄 RNA에는, 이 siRNA도 포함된다. 또, 본 발명의 이중쇄 RNA를 발현할 수 있는 DNA도 본 발명에 포함된다.
본 발명의 바람직한 태양에 있어서는, 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)의 발현을 RNAi 효과에 의해 억제할 수 있는 RNA(siRNA)로서, 배열번호: 724~809, 974~1063의 어느 하나에 기재된 염기배열로 이루어지는 RNA와, 당해 RNA와 상보적인 배열로 이루어지는 RNA가 하이브리다이즈한 구조를 포함하는 이중쇄 RNA를 유효성분으로서 포함하는 암세포 특이적 아포토시스 유도제를 제공한다.
예를 들어, 배열번호: 724에 기재된 염기배열(5'-ggaaaaucuggccacucucTT-3')을 포함하는 본 발명의 siRNA란, 이하와 같은 구조의 RNA분자를 예시할 수 있다.
5'-ggaaaaucuggccacucuc-3'
IIIIIIIIIIIIIIIIIII
3'-ccuuuuagaccggugagag-5'
(상기 「I」는 수소결합을 나타낸다.)
또, 상기 RNA분자에 있어서 한쪽의 단이 닫힌 구조의 분자, 예를 들어 헤어핀 구조를 갖는 siRNA(shRNA)도 본 발명에 포함된다. 즉, 분자 내에 있어서 이중쇄 RNA구조를 형성할 수 있는 분자도 본 발명에 포함된다.
예를 들어,
5'-ggaaaaucuggccacucuc(xxxx)n gagaguggccagauuuucc-3'과 같은 분자도 본 발명에 포함된다(상기 「(xxxx)n」은 임의 염기 및 배열수로 이루어지는 폴리뉴클레오티드를 나타낸다).
상기 siRNA의 바람직한 태양으로서는, 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)의 발현을 RNAi 효과에 의해 억제할 수 있는 RNA(siRNA)로서, 배열번호: 724~809, 974~1063의 어느 하나에 기재된 염기배열로 이루어지는 RNA와, 당해 RNA와 상보적인 배열로 이루어지는 RNA가 하이브리다이즈한 구조를 포함하는 이중쇄 RNA를 매우 적합하게 나타낼 수 있다. 단, 이중쇄 RNA의 말단에 있어서, 예를 들어 1 또는 복수의 RNA가 부가 또는 결실된 구조의 이중쇄 RNA도 본 발명에 포함된다.
즉, 본 발명은, 본 발명의 이중쇄 RNA를 발현할 수 있는 DNA(벡터)를 제공한다. 본 발명의 상기 이중쇄 RNA를 발현할 수 있는 DNA(벡터)는, 통상 당해 이중쇄 RNA의 한쪽의 쇄를 코드하는 DNA 및 당해 이중쇄 RNA의 다른 쪽의 쇄를 코드하는 DNA가 각각 발현할 수 있도록 프로모터와 연결한 구조를 갖는 DNA이다. 본 발명의 상기 DNA는, 당업자에 있어서는, 일반적인 유전자 공학기술에 의해 용이하게 제작할 수 있다. 보다 구체적으로는, 본 발명의 RNA를 코드하는 DNA를 주지의 여러 가지의 발현벡터에 적절히 삽입함으로써, 본 발명의 발현벡터를 제작하는 것이 가능하다.
RNAi를 위해서 사용되는 RNA는, 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자) 또는 당해 유전자의 부분영역과 완전히 동일(상동)할 필요는 없지만, 완전한 동일(상동)성을 갖는 것이 바람직하다.
본 발명의 RNAi 효과를 갖는 이중쇄 RNA는, 통상 염색체 안정화 관련 유전자( 예를 들어, 상기 어느 하나에 기재된 유전자)의 mRNA에서의 연속하는 임의의 RNA 영역과 상동인 배열로 이루어지는 센스 RNA 및 당해 센스 RNA에 상보적인 배열로 이루어지는 안티센스 RNA로 이루어지는 이중쇄 RNA이다. 상기 「연속하는 임의의 RNA 영역」의 길이는 통상 20~30 염기이고, 바람직하게는 21~23 염기이다. 예를 들어, 배열번호:724~809, 974~1063의 어느 하나에 기재된 RNA를 한쪽의 쇄로 하는 siRNA의 길이를 들 수 있는데, 반드시 이들의 길이에 한정되지 않는다. 그러나, 그대로의 길이로는 RNAi 효과를 갖지 않는 장쇄의 RNA이어도, 세포에 있어서 RNAi 효과를 갖는 siRNA에 분해되는 것이 기대되기 때문에, 본 발명에서의 이중쇄 RNA의 길이는 특히 제한되지 않는다. 또한, 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)의 mRNA의 전체길이 또는 거의 전체길이의 영역에 대응하는 장쇄 이중쇄 RNA를, 예를 들어 미리 DICER로 분해시키고, 그 분해 산물을 본 발명의 아포토시스 유도제로서 이용하는 것이 가능하다. 이 분해 산물에는, RNAi 효과를 갖는 이중쇄 RNA분자(siRNA)가 포함되는 것이 기대된다. 이 방법에 의하면, RNAi 효과를 갖는 것이 기대되는 mRNA상의 영역을 특히 선택하지 않아도 된다. 즉, RNAi 효과를 갖는 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)의 mRNA상의 영역은, 반드시 정확히 규정될 필요는 없다. 단, 보다 바람직하게는, 후술하는 실시예에 있어서 사용한 각종 siRNA를 매우 적합하게 나타낼 수 있다.
또한, 통상 말단에 수염기의 오버행을 갖는 이중쇄 RNA는, RNAi 효과가 높은 것이 알려져 있고, 본 발명의 이중쇄 RNA는 말단에 수염기의 오버행을 갖는 것이 바람직하다. 이 오버행을 형성하는 염기의 길이는 특히 제한되지 않는다. 또한, 이 오버행은, DNA 및 RNA의 어느 것이어도 된다. 바람직하게는, 2염기의 오버행을 예시할 수 있다. 본 발명에 있어서는, 예를 들어 TT(티민이 2개), UU(우라실이 2개), 그 밖의 염기의 오버행을 갖는 이중쇄 RNA(가장 바람직하게는 19염기의 이중쇄 RNA와 2염기(TT)의 오버행을 갖는 분자)를 매우 적합하게 사용할 수 있다. 본 발명의 이중쇄 RNA에는, 이와 같이 오버행을 형성하는 염기가 DNA인 것과 같은 분자나, 표적 mRNA 배열과 상동인 배열도 포함된다.
예를 들어, 오버행 부분의 염기가 TT인 경우에는, 본 발명의 siRNA 분자로서는,
5'-ggaaaaucuggccacucucTT-3'
IIIIIIIIIIIIIIIIIII
3'-TTccuuuuagaccggugagag-5'
와 같은 분자(3´측에 TT가 부가된 분자)를 예시할 수 있다.
본 발명의 상기 「염색체 안정화 관련 유전자에 대해 RNAi 효과를 갖는 이중쇄 RNA」는, 당업자에 있어서는, 당해 이중쇄 RNA의 표적이 되는 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)의 염기배열을 기초로 적절히 제작할 수 있다. 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)의 염기배열은, 상술한 바와 같이 공공의 유전자 데이터베이스로부터 용이하게 취득할 수 있다. 일례를 나타내면, 배열번호: 1~637, 810~908의 어느 하나에 기재된 염기배열을 기초로 본 발명의 이중쇄 RNA를 제작할 수 있다. 즉, 배열번호: 1~637, 810~908의 어느 하나에 기재된 염기배열을 기초로 당해 배열의 전사 산물인 mRNA의 임의가 연속하는 RNA 영역을 선택하고, 이 영역에 대응하는 이중쇄 RNA를 제작하는 것은, 당업자에 있어서는 용이하게 행할 수 있는 것이다. 또한, 당해 배열의 전사 산물인 mRNA 배열로부터, 보다 강한 RNAi 효과를 갖는 siRNA 배열을 선택하는 방법은, 예를 들어 문헌(Reynold et al. Nature biotechnology 22. 326-330(2004), Ui-Tei et al. Nucleic Acids Res. 32. 936-948(2004), Boese Q, Leake D, Reynolds A, Read S, Scaringe SA, Marshall WS, Khvorova A. Mechanistic insights aid computational short interfering RNA design. Methods Enzymol. 2005;392:73-96., Snove O Jr, Nedland M, Fjeldstad SH, Humberset H, Birkeland OR, Grunfeld T, Saetrom P. Designing effective siRNAs with off-target control. Biochem Biophys Res Commun. 2004;325(3):769-73., Yiu SM, Wong PW, Lam TW, Mui YC, Kung HF, Lin M, Cheung YT. Filtering of Ineffective siRNAs and Improved siRNA Design Tool. Bioinformatics. 200515;21(2):144-51, Chalk AM, Wahlestedt C, Sonnhammer EL. Improved and automated prediction of effective siRNA. Biochem Biophys Res Commun. 2004;319(1):264-74., Amarzguioui M, Prydz H. An algorithm for selection of functional siRNA sequences. Biochem Biophys Res Commun. 2004;316(4):1050-8., SioudM, Leirdal M. Potential design rules and enzymatic synthesis of siRNAs. Methods Mol Biol. 2004;252:457-69.) 등을 참고하여, 당업자에 있어서는 적절히 실시하는 것이 가능하다. 또한, 한쪽의 쇄(예를 들어, 배열번호: 724~809, 974~1063의 어느 하나에 기재된 염기배열)가 판명되어 있으면, 당업자에 있어서는 용이하게 다른 쪽의 쇄(상보쇄)의 염기배열을 알 수 있다. siRNA는, 당업자에 있어서는 시판의 핵산 합성기를 이용하여 적절히 제작하는 것이 가능하다. 또한, 원하는 RNA의 합성에 대해서는, 일반의 합성수화 서비스를 이용하는 것이 가능하다.
또한, 본 발명에서의 siRNA는, 반드시 모든 뉴클레오티드가 리보뉴클레오티드(RNA)가 아니어도 된다. 즉, 본 발명에 있어서, siRNA를 구성하는 1 또는 복수의 뉴클레오티드는, 대응하는 디옥시리보뉴클레오티드이어도 된다. 이 「대응하는」이란, 당 부분의 구조는 다르지만, 동일한 염기종(아데닌, 구아닌, 시토신, 티민(우라실))인 것을 가리킨다. 예를 들어, 아데닌을 갖는 리보뉴클레오티드에 대응하는 디옥시리보뉴클레오티드란, 아데닌을 갖는 디옥시리보뉴클레오티드를 말한다. 또한, 상기 「복수」란 특히 제한되지 않지만, 바람직하게는 2~5개 정도의 소수를 가리킨다.
또한, 본 발명의 이중쇄 RNA의 기초가 되는 유전자(표적 유전자)의 배열은, 반드시 유전자 전체길이의 염기배열이 판명되어 있을 필요는 없다. 선택해야 할 임의의 연속하는 RNA 영역(예를 들어, 20~30 염기)이 판명되어 있으면 된다. 따라서, EST(Expressed Sequence Tag) 등과 같이 mRNA의 일부는 판명되어 있는데, 전체길이가 판명되어 있지 않은 유전자 단편으로부터도, 당해 단편의 염기배열을 기초로 본 발명의 이중쇄 RNA를 제작하는 것이 가능하다. 이하에, GenBank 데이터베이스에 있어서, 상기 어느 하나에 기재된 유전자와 높은 상동성을 나타낸 EST 배열의 액세션 번호를 각 유전자명마다 나누어 기재한다. 단, 이들은 다수 존재하는 EST 배열 중의 일례에 불과하고, 당업자에 있어서는, 적절한 EST 단편에 관한 정보를 공공의 데이터베이스로부터 용이하게 취득할 수 있다.
Mcm10: BQ230201, CK000876, BX324498, BM466246, BI086715, BE561621, BM781578, BE397209, BM781561, BF797760, BE268770, AI133628, BI860489, CA488245, BE018388, BM794417, AI005288, AV759891, BE536223, AI078425, BI023355, CB120985, AA305452, BX324497, AI636632, CB143720, BM465842, BM833978, AI962581, BE206240, BE536858, BQ432059, BX099770, BX346400, BE890219, BU542039, AI750442, BU542210, BQ929138, BG323332, AA312197, BG942019, BM755471, AA091854, BX346399, BG493975, T97047, BU615340, BG777950, BU618352, BG323324
Orc1: BM556110, AL558857, AL528479, AL530422, AU125429, BQ229865, BX370588, AL563154, BU552785, BQ055912, CD642483, BE903488, BU854876, BM908744, BF205157, BX372245, BQ230059, BX110476, BM743410, BG821765, AL530421, BI222366, BU198520, BF796650, BM476715, AL552393, AU127396, BM740840, BE781976, AL580583, BG391980, BM852299, CD654548, BQ423782, AW378723, AL582531, AL561250, BU194186, BQ048846, BG822626, AL552501, BU854819, BQ433201, BE782505, BG257286, BX281133, CF140351, BF795920, BG390855, BG831652, BF794915, BF797918, BG325714, AI651655, BM833692, BQ883238, BX474463, AI038384, AU129034, BP431296, BG328342, BP430683, H51719, AI739661, T96858, BE782390, BU630113, BG025019, BE937466, AA332534, AI343281, AU149094, BP430714, BI087773, AW393255, AU151220, BE076727, AI452809, AW877655, AI003527, AI391554, AW602975, AW877662, AA633915, BF108860, AU149996, T96859, R83277
Orc3: BM478060, BU509511, BQ718539, BU153003, AL533919, BQ220405, AU118962, BM550235, BG187255, AU117920, BQ719965, BQ716606, BQ953945, BU166296, AU119182, BI769170, BI819545, CD655888, BX409716, BI520392, BG214275, BI770086, BI091781, BM802602, BG187780, BU170385, BI769508, BX433033, BX507848, AU124361, BX488094, BM785800, BG205874, CD679490, BX490513, CB153029, AW967051, BM826548, AU139285, BG572634, AL533918, CB152486, AU136510, BE536929, BX352629, BQ102522, AW369628, AW449272, BF672680, BE882468, BX343146, BG943457, BF698289, CD702536, BF667912, AU280292, CA842624, BF674961, BF184165, BQ441255, BF794512, CD699734, AL600904, BX462706, BF215571, AL709158, AV753736, AI904063, CB123265, BX486937, BG214276, CD245870, BF059711, AI651375, BQ102253, AL711211, BF964587, AW500090, BM751168, CB963370, BI862225, AA442539, AW887723, AW801684, AV708200, BM152858, H17704, BF683230, BM848524, BQ772810, BQ361466, AL710982, CD242978, H11812, AA305227, AW607564, H94935, BU632641, BX328353, BI255412
Cdc6: AL562624, AL521818, BM465884, BQ064897, BX451346, BX349920, BU846236, BQ675107, BI260747, BU633837, BG256606, BM464160, BQ228599, BG252312, BM559225, AL521819, BE907412, BQ070080, BU619893, BF698043, BE741201, AL526150, BG765988, BU173127, BF699051, AA502608, BG165110, AU129648, CA488634, BM450676, BF028885, CB135870, BF185000, BG026757, CA429336, BF977528, BF240966, BG766090, AI478744, BM803439, AA045217, AA813386, BE565947, BF571756, AL710150, BF307679, AA723372, BG721945, AI433558, BF208758, BI559407, BX482661, BF102841, BE779410, BQ441118, N69246, BF310791, CF123750, BI006635, BQ775002, AA907374, BM011340, CA429634, W03300, BM845715, AA113790, BF210909, BM706052, H59204, BI255053, AI424746, H59203, AI052065, BE073887, BE550416, AI341585, BG025851, BF221502, T83032, T90351, BG720011, AI953729, AI699473, BF115521, BF223422, AI808683, BE085836, AI699980, BX355209, BE086769, AW518847, AA099980, BE965778, AA836395, AI766778, BE869748, AI802324, AA584340, BE693538, AI567411
Cdt1: BX332414, BQ935210, BU931977, BM811548, BU849056, BQ062875, BQ053758, BU187852, BX406047, AL555432, BQ278148, BX402195, BU845736, AL580756, BQ058496, AL581992, BX332413, AL557066, BU930971, BM016975, BX421258, BU190377, BQ960305, BG824304, AL520240, BM917547, BQ053108, AL582018, BG393757, AL520239, BF791881, BM019024, AL556319, BI092793, BI258203, AL559054, AL527465, AL558613, BU856820, AL524910, AL580393, BX333703, BQ063175, BG259986, BI335580, BG327660, BM556535, BI222927, BG251456, AL520887, BI224536, BI335105, AL524909, BQ053124, BI093258, BG745159, BX405984, AL515463, BE910713, AL518299, BQ054892, BQ053069, BI333817, AL518300, BU189533, BI260243, BF972427, BQ684815, BM695575, BQ652285, BQ649771, BQ647760, BQ647212, BQ645148, BG822442, AL581566, BQ652445, BQ649937, BE544515, AL577935, BX405983, BM927844, BE727635, AL515464, BU176676, BU931060, BU859159, BX366934, BX355022, BM800496, BM463356, BG389325, BU164161, BE388067, BX464574, BE778380, BF237902, BU158281, BM917445, BM809482
Geminin: BM550773, AL522354, BI092791, BX375519, BX414734, AL562503, BI861855, BM471496, AL518006, BQ430578, AL580178, BG577005, BG032232, AL525229, AL518005, AL522353, CA417249, AU118695, BQ645204, BG612964, BI855710, BQ718513, BG577324, BI086620, AL558330, BG776051, BG777134, BE893489, BF967933, BG776192, AW996997, BF666338, BQ015308, BQ064691, CD366250, BE910343, BM699599, BG776218, BF029154, BU629613, CB992796, BG825264, BE613337, CB131959, CB049968, BQ772723, BE564333, BI759810, BF666672, BF808421, BF700297, BG337926, BE565866, BG776386, CD367234, BF213350, CB136099, BI830428, BG612435, BE535264, BQ575533, BF667576, BG505022, AA447810, CA442918, BU623074, BF696555, AA393139, CD708137, BF699912, BF967209, BF056288, CA503202, CA312813, BG530534, BF109418, AV756510, BG778341, AA235222, BI093913, BF248391, AI968057, CD686529, BU685799, BG777305, AV734242, AV689368, BF240393, AW006287, AI828103, BF003138, CB049969, BF947954, BF594599, BE048465, BG429246, BG180421, AI803434, AV734302, BE219705
Mcm3: BM467763, AL551465, BQ066322, BQ061652, AL559830, BQ059704, BM471050, BU849776, AL545116, BQ063041, BU541430, BU860117, BM542415, AU124791, BU857116, BM453648, BQ056448, BM927480, BQ218351, BQ057647, BQ940737, AU119321, BX462455, BQ898140, CF995699, BI772155, AL549372, BQ214499, BU856617, BM007763, BI223143, BQ652945, BQ649476, BU509755, BQ058522, BQ641758, BQ064200, BG281527, AU133404, BE249947, BU601317, BU154249, BQ927115, BI457651, BX462766, BU558287, BQ051029, BM917594, AU134083, BM561561, CD656673, BQ422727, BQ058080, BM478599, BQ881515, BE795211, BI196606, BG034961, BE892181, BQ649956, BM479437, BG765473, AL527918, BE560376, BI261474, BI599305, BX348989, BE793456, BM461732, BE620320, BE783059, BE799563, BE561200, BQ064568, BE620857, BG681460, BE616575, AU124152, BM832703, BG392301, BG259417, AW083217, BI086286, BQ650935, BI259905, BG686972, CD642696, BI091236, CD655620, BI551396, BE778348, BG773437, BU193733, BE274144, BE891644, AW732422, AU131124, BG742232, BU178300, AU123260
Mcm4: BX363316, BM557639, BM479183, BU163628, BX341147, BQ956710, BQ689703, BU855555, BM423607, BQ689028, BQ684773, BU149764, BM917541, BQ877570, BQ962733, BQ213101, BQ679476, BQ931933, BQ670123, BQ680471, BQ878671, BU196152, BQ218770, BQ687458, BQ058022, BU838204, BQ231069, AU124599, BQ060869, AI936566, BQ066067, BQ066435, BU182872, BQ065206, BQ061896, AL710281, AU125558, BM560344, AU124716, AU130095, BX341146, BQ060907, BG683134, AU131502, BM909380, BI259276, BQ676347, BQ054534, BU601939, BQ056963, BQ883247, AU124662, AU134265, BQ681631, BI092911, AU124469, BU151359, AU131979, BU860012, BQ058401, AU126357, BE740475, BG772025, BU154598, BF058934, BQ670493, BI520579, BQ681697, CD643530, CD655257, BQ948077, BE796484, BQ681384, AI738700, BF569146, AU124670, BQ772225, BI117233, AI923706, BX100324, BF059052, BQ652623, AU131348, CF265157, CF594355, BU940867, BG339157, BF116228, BQ682913, BG029854, BG421025, BG248645, BI223223, BE891270, BE741088, AU130533, BG684174, BQ675821, BI830911, AU136189
Mcm5: BX446933, BX443180, BU179314, BX465121, BX360307, BQ219621, BQ059059, BX374727, BM560991, BM802651, BU148505, BM478574, BM480184, BX407417, BM558890, BU538182, BX331301, BX465031, BQ893665, BQ671418, BM559170, BX331344, BU156108, BQ645833, BQ069574, BX458285, BQ895922, BQ057750, BQ054136, BQ957762, BX367432, BG767144, BQ065023, BQ055590, BM470663, BU839673, BQ065213, BX368805, BU192073, BQ065931, BQ232104, BM917136, BQ880654, BX346462, BU163845, BQ672003, BQ434878, BQ647973, BG770644, BU557340, BU165017, BG760478, BQ671606, BU541449, BQ670216, BQ649375, BI086963, BQ669996, BI909897, BQ935556, BM043366, BQ642797, BU195081, BQ222354, BU190738, BI869446, BX346537, BQ066237, BG770167, BU557310, BX465120, BX388269, BQ943544, BQ069268, BQ679299, BQ683703, BG576914, BX341163, BM051781, BM719141, BQ440728, BQ431588, BQ643976, BX381461, BU845031, BU839453, BQ213876, BX407118, AU131148, BG685544, BU178502, BQ929382, BU556785, BM457715, BU166135, BM927634, BE735173, BX428497, BX407353, BE253723
Mcm6: BM563815, BQ689609, BU178707, BU185218, BM917146, BU180530, BQ691498, BM917702, BQ721374, BQ430793, BQ710328, BQ276415, AU124829, BM551692, BM457121, BQ919455, BQ688139, BQ685964, BQ424418, BM453163, BQ671824, AU143594, BU542273, BU146898, BU178966, BQ072203, BM461535, AU131056, AU133299, AU125636, BU180371, BE383991, BU181929, BQ691761, AU125495, BG686841, CD242701, BG685821, AU117647, BX483567, BM564401, BG390247, AU133321, BI870675, BI084962, BE731324, BI084168, BG532524, AU126102, BM803211, BE734309, BM450955, BG419290, BU146822, BM013848, BG680470, CD643818, BU176030, BM917579, BM045567, BE733405, BG877987, BG538573, AU142944, AU130133, AU124506, BE796828, AU137338, BG253660, BQ879136, BG386500, BM048943, BG914034, AU124893, BX451899, BM012817, BG389994, BG030690, BE731558, BG877979, BE407913, BG878155, BX416717, BE385730, AU128720, BE618973,BE268695, BX118733, BG256582, BG878151, BE513514, BG877982, BG335342, BE281191, BE778969, BM842510, BG878152, BG877994, BU506698, BE280389
Mcm7: BX446600, BM916932, AL555833, BM451540, BX342306, BX424231, BQ279230, BM462954, BM468766, BU500250, BM803547, BM557336, BX443366, BQ070647, AL561620, BX355367, BM908241, BQ924446, BQ887320, BM912799, CD108811, BX324854, BQ643995, BM463747, BU183306, BM927622, BQ055649, BQ053452, BX428085, BQ673910, BM921077, BQ887860, BQ883251, BU147232, BQ071179, BQ935246, BQ652903, BQ883056, BQ674104, BQ641811, BQ053620, BM917214, BU162886, BQ052004, BQ891995, BQ878240, BQ953990, BQ063971, BX405959, BQ898941, BQ061151, BQ054401, BQ917453, BM564271, BU189313, BQ058499, BU161199, BM469583, BQ218009, BI522846, BU855416, BQ056795, BQ643247, BQ069037, BQ920442, AU125112, BU194965, BU854868, BU183465, BQ720104, BQ228405, BQ214543, BQ064840, BQ650571, BQ642612, AU125755, BQ956957, BU526752, BE740091, AL561593, BU165222, BE792286, BQ643233, BQ676107, BQ070446, BQ225752, BQ670399, BQ932333, BM810332, CD051232, BU527906, BU942698, BI335520, BQ057726, BM554740, BE799854, AU124962, BM914800, BI825746, BX324853
Mcm8: BQ055956, BQ070426, BM454681, BU556999, BM904262, BQ441929, BM559514, BM808018, BM459480, BM808016, BQ070219, BM009484, BQ940417, BU162199, BM558689, BM912457, BQ434761, BI862190, BM810194, CD642958, BG422937, BG338287, BM015340, BI859244, BG762185, BU509003, BG420680, BG023796, BF309111, BM453735, BM466057, CA495297, BF306586, BE513731, BI086506, BM009302, BX504348, BE898012, BG338630, AW955317, BE273079, BG827920, BG396259, BE269095, BM793002, CF137101, BF308208, BM913291, CA425682, AW960988, BX282225, BG168597, BF973469, BE278386, AV645497, AA325061, BE311854, BG339877, BF754616, W94454, CB136734, BI225492, BG434327, CA445505, BG761050, W25728, BM751186, BE842789, BM825974, BU955551, BF127844, BQ007416, CD299273, AI086063, BE928109, BF088599, AA225696, BQ071854, AA226268, AW440309, AA370141, AA193063, BQ334627, AW845751, W94336, AA609373, CA436668, AI609077, BQ320963, AA563920, AI537281, AI200790, BG259140, AI219139, AA192859
Cdc7: CA441701, BG170872, BM463748, AL044123, BE789148, AU120443, AU129167, AU116849, AW968900, AW574512, BI462237, AL602215, BM789148, CB959717, AL039323, AA814975, AA936081, BG721963, BU657893, CB216422, AU117631, AA768993, AA131310, BF366907, W76628, N40295, BF982876, AA488999, AW405542, AL044122, BF031756, BQ221549, AA291015, BX419687, BF696442, AA488783, CD523327, BG116756, D20593, CD689440, BG116838, BU568048, CD642993
Cdc5: BX350355, BU192616, BQ427813, BQ961587, BI222621, BQ962695, BX331396, CD107746, BQ427606, BE275179, BF982513, BU195085, BX483740, AL558731, BG431157, BM450338, BM925609, BU073210, BG028239, CB306835, AL706102, BG178910, BF025810, BX446071, BU508497, BM718344, BX349125, BQ423785, BM505336, BF977508, BI823054, CD103634, AL135197, AU135978, BF132826, CB160730, AL710914, AI679458, BE617311, BG390164, AW959030, BU933396, BF217466, BG502998, BM894208, AW268817, CF135420, BM146535, BU071659, BE884277, CD101983, BF035463, BG424071, AI143113, AA044750, CF143619, BG722285, BM127700, BG327622, AI122932, BM804765, AV682172, AW954903, AI279537, AL580487, BM894481, BE781164, CK024078, AV762357, BF744457, BM834441, BG121920, BE541230, BF679988, AA811533, AI221677, BG897659, CB052718, AU136923, BU623810, BG497404, CA448370, BF813646, BI048250, BF214089, AU131684, BG540599, BG942273, AA191036, BP429997, AA249176, AL710062, BE140574, AU127833, BG614948, BE140795, AI583919, AI909768, BI918547, BF795413
Psf1: BM458856, BU171017, BM450503, BX384069, BQ070512, AW499844, BM151985, AA860312, BF692084, BU430742, AI190765, BQ440331, BM152648, AA725561, AA383128, BM465819, BU659306, BI333600, AA355925, BG910353, BI223929, BF892016, AU099454, AL044646, AI184188, N39921, N39947, AU076561, AL597443
Psf2: BU597296, BU184963, BM449472, BM043804, BF683514, BF311745, BE514071, BE513254, BE382866, BQ277667, BQ229290, BG825252, BG772776, BG284180, BG104289, BF795157, AU126087, BF035586, BE796384, BE795838, BE795306, BE561044, BE274253, BE312319, AW249012, CK001498, AL560880, AL560669, BQ233393, BG420251, BE267495, BE258240, CA455226, BE251065, BU957713, BE791539, BE267221, BX415204, BI196248, BG118214, AL529785, BU595469, BF310321, BI257993, BF684568, BE561525, BE251621, BG475509, BG527542, BE793125, BE562088, BG519560, BG475384, BE259285, BU601226, BG339264, BX456910, AV712739, BF312439, AL526847, BU603101, BE260083, BI832397, BU940719, BE255698, BE514978, AA521273, BG469677, BF209856, AL563552, AI828992, AI583174, AL582217, CB112523, BF238335, BG531588, CB129701, BF312015, BE878751, BU625683, AL582077, BE222543, AA262870, AL562756, AW958853, BU506537, BQ361100, AA251319, BM832297, BE296429, AI827298, AL560926, BE907417, BU729618, BE799212, BE268868, BM126492, BE262182, AA053046, AL582250
Psf3: BQ231741, BQ948256, BI489800, AL555105, AL524624, BM904357, AL525185, BX406244, AL529159, AL550963, AL524746, BI753591, BI770007, AL561070, BM016893, BG387533, BQ422835, BE782757, BF316873, BF797649, BG765190, BF796771, BM925118, BM722252, BG769825, CF141388, CD676320, BE749159, AL711201, BE297646, AW674872, BQ645203, BM926055, CD693113, BM804294, BG257517, CF552524, BM786881, BF797402, AU142374, BE208552, BF239248, BF310190, BQ890204, BE256868, BG249299, BE907809, W79671, BM754989, BX328153, BU939987, BE281396, CA430225, BQ304813, BQ027991, BM542908, BF769732, BG744402, AA353408, BP430213, BM564422
Cdc45: BM550683, BX366266, BX358668, BM478173, BX345270, BX355266, BX366366, BM557094, BM557313, BX358667, BX346442, BX371229, BX352708, BX366365, BX451104, BX352909, BX349664, BX331394, BX328445, BQ069733, BX448615, CA454819, BX448616, BX447114, BX349663, BU184174, BX328421, BQ427880, BX328446, BX451105, BX352910, BX334120, BX409672, BQ214084, BU171037, BQ233704, BX391089, BE747427, BX346464, BX428526, BX422691, BX331393, BX367431, BX367477, BX391088, BX367513, BX325504, BX352709, BX362080, BX367505, BF026159, BE869669, BX325558, BX366268, BE260534, CB124085, BX371230, BG122390, BG387745, BG252967, BG180337, BE897594, BX367410, BM917964, BX346526, BX328422, BQ674776, BM912689, BQ436443, BF965716, BX376594, BG720395, BF125841, BI546622, BQ216400, BU537659, AL711006, CF139190, BU618386, BX367472, BX328725, AI768340, CA454402, AW081615, BX366267, BM751026, BX328423, BE795241, BU618460, BE255146, BG386934, AI369688, BX367409, AW674262, BE903958, AW674908, AA700904, BX389190, CF141215, BE501602
Pola p180: BU508486, AL543898, AU121118, CB134498, AU132112, BX327138, BQ883339, CB121808, AW674983, CB149914, CB140712, CB152927, BQ882043, AL570197, BF210579, BE835570, BE818389, AA379019, BE837514, BQ312037, BE837504, AI354751, BM475170, CB122291, AL044294, BE771020, AA355814, BQ351870, AW589637, AA383406, BE717631, R72191, BX117096, AA828105, BF888988, AI261685, BE163167, BE817842, CD000139, CB999470, BF899310, BG926114
Pola p70: BU508486, AL543898, AU121118, CB134498, AU132112, BX327138, BQ883339, CB121808, AW674983, CB149914, CB140712, CB152927, BQ882043, AL570197, BF210579, BE835570, BE818389, AA379019, BE837514, BQ312037, BE837504, AI354751, BM475170, CB122291, AL044294, BE771020, AA355814, BQ351870, AW589637, AA383406, BE717631, R72191, BX117096, AA828105, BF888988, AI261685, BE163167, BE817842, CD000139, CB999470, BF899310, BG926114
Pola Spp1(Prim2a): AL556161, AL513776, BM546142, AL549894, BX401418, BU187783, BM459297, BU193561, BI523986, BI907286, BG034836, BG215267, CF595567, CA406143, BX280180, BM926617, BF572603, BQ947185, BX404971, BM852865, BM756079, BI547222, BF978626, AL578476, BF747008, BX401417, AL573915, BF745947, AV757142, CF140555, AI557036, T75233, BF745931, BF744295, BM464505, AA465014, T10253, BG183395, BE697488, BG205656, BG209815, BG195945, AA434502, CB113799, BG184433, BF746454, BE766105, AA361880, AA255550, BG191366, BE766167, BE766098, BE766038, BE765690, BE769157, N80963, AI216670, BX114039, AW951150, N80656, BE714429, AA255569, BE843957, R61073, BE714404, BF000349, AA093814, BE538394, T93658, R00642, F12922, BE543709, BF172325, T05292, BQ001605, CA411912, BX455830, BM551302
RPA70: BM456944, BQ222582, AU119564, AL576308, AU124434, AU125631, AU122638, BM556841, BQ222302, BM542894, BU177749, BU508590, BM456314, BM466291, BG108961, BX425090, BU633264, BU153418, BU184357, BU517134, BG251944, BG828190, BG764082, BI858388, BG758555, BG035161, BG287240, BF796027, BG036436, BG826869, BX488619, BF971387, BM790584, BG119012, BG765594, BG685852, BE292972, BG761657, BE898956, BE743787, BE897915, BF983057, BF665538, BM792560, BI253949, BG755233, AU125797, BE178302, BI093003, BG120570, BQ218906, BM743518, BM742537, BF698180, BE178464, CD579303, BM848213, BM844440, CF121414, BF344035, BM838207, BE927446, CB121597, BE542431, BF664182, CB115068, BM847443, CD580024, BM848384, BF028723, BM851538, BE927448, BE773962, BE773949, BF751549, BM016568, BQ214159, AA460805, BE764622, AU128580, BG029093, BF082772, BX339968, CB130706, BQ230034, BM711058, CB160550, BE927450, BU501405, BE932015, BE773964, BF699259, BF919259, BE932029, BM541370, BM462468, BE171973, BM845370, BX477548, AL553255
RPA34: BX333932, BQ064852, BX442975, BQ069120, BQ943330, BQ063763, BQ674220, AU118399, BQ059648, AU143441, BQ673815, BQ439053, BQ278675, BU856528, BE741729, BQ066157, BG825398, BQ668543, BI600038, BQ641985, BI757393, BG333934, BQ054635, BQ070050, BQ066715, BI518754, AI419040, BE271646, BQ063545, BQ058415, AI890508, BM543895, BG336979, BE898769, BI818496, BG421195, BE901546, BG469742, BE887147, AU134052, BI756891, BF308713, BM312218, BE902956, BG433978, BG334708, AI744901, BG254134, BU943380, AI929664, CA488595, BE298500, BG826547, BE394497, BI599375, CK002534, BG779099, BE313107, BE298150, BG501316, BG826213, AU129936, BQ059808, AU126353, BI113916, BE297131, BG424340, BQ642824, BI193274, BI546749, BG716673, BQ055902, BG777777, BG428439, BE019650, AV762431, CD687322, CA842220, BE898527, BE294795, BG616118, BG615827, BF791819, BE568731, BQ059622, BQ054654, BG436837, BF686542, CD702944, CD710078, BG479643, BE898609, BM698831, BQ924421, BE394931, AI961707, BX283385, AA641800, CB145745, BF692608
PCNA: BM464765, AL547405, BU162573, BQ233597, BM923901, BM475636, BM809424, BU506972, AL549034, AL549068, BI254350, BU187589, BG686220, BQ716438, BM477662, BM542830, AL572455, BM474328, BQ231284, BU195180, BU161781, BG774625, BQ681114, BQ649204, BU634227, BM474327, BI765443, BM979950, CD519986, BU626265, BQ682146, BI767353, BG707111, BQ679867, BG755768, CD367344, BI254540, BG166783, BQ014636, BI598197, BM977646, BU624262, BG686801, BM016212, CA442951, CA443088, BM976306, BU628431, BQ009665, BE889822, BE738456, AA910951, BQ218579, BI829094, BI226337, BQ050978, CD238945, BG503955, BE888544, CD367010, BQ429019, BM466077, AI348072, AA843679, BE739511, BG540339, BF685141, BM842748, BM829821, AI125272, BU656120, AV717345, BU154500, BI831672, BG533644, BM850147, BQ016237, CB529827, CA446890, BQ447329, BM781704, BG503385, CD364739, BG614065, BG290688, BQ681737, BE887284, BE883191, BG613869, BE746433, CB529409, BQ016228, BQ003193, BG502601, BX473856, CA443057, AV649575, BM995025, BU154811, BG532459
Elg1: BX435523, CD643489, AW976468, CB161634, CB051111, BE551573, AW514252, BE042824, AI621250, AI623298, BF669931, AA651909, AW450012, BG389184, CD644045, AA972691, AU149697, BU509262, AA724028, AU126948, AI656767, BI094506, BU428574, BF243394, BE886708, BX102408, AA744478, W87913, BF212165, BE834403, AA857981, AA136031, AA703271, D29036, BE152409, BX109066, H56423, H68973, BE005696, BX461696, AA610813, BE834436, BM312382, AI078312, BG207827, N90506, BG197401, BM724358, CB051112, BE148289, AA806690, AW978010, BX108248, BX104136, AL712199, BG619264, BE163388, AA976805, AA707097, AA705010, AA702235, AA436301, AA436174, H59615, BU682299, BF993160
FEN1: BU538692, BX397634, BQ058498, BX424210, BX333531, BU170538, BX443166, BU860300, BQ888965, BQ880548, CA489528, BX433300, BM015629, BX448621, AL560007, AL531350, BX331605, BU535646, BQ957039, BU931957, BX445725, BG828048, BU167885, BM561765, BM560757, BG575417, BU931950, AL519300, BQ918754, BM546237, BX425258, BQ642352, BU538026, BQ641309, BU178840, BU553925, BQ690414, BU539094, BG574950, BX448789, BG337603, BM552061, BQ053379, BQ424018, BF686180, BU176039, BG676364, BQ064038, BU170972, CA454699, BU859837, BI116779, AL560377, AL560395, BE793493, BG576479, BE792164, BG756459, BG773958, BE311755, BE796307, BG474425, BI767742, BX394237, BM542385, BE795541, BI827898, BU931956, BE799080, BE397382, BQ050062, BE796569, BI117469, BQ227585, BI115669, BE780262, BE274648, BQ946363, CF131987, BM917670, BG825257, BU189559, BM803891, BU856251, BU165752, BE794075, BE793759, BQ777102, BI256835, BU541327, BU152651, BE799325, CD243456, BQ278519, BQ219034, BG287218, BI334366, BI116455, BE798996, BG472198
DNA2: BX390869, BX329314, AL527195, BG289876, BI869219, BX384719, CD644575, BG106738, BE866952, BG117032, BG036343, BG177711, BE748018, AW134972, AA284382, BG501340, BX384718, AW369063, AW369067, BU658975, BF213278, AW367239, AA282895, BE085640, BQ435874, C20980, BG944343, CD514528, AA974495, AA830575, AA767191, AA748680, AA282803, AW977920, AA732685, AW367310, BF089037, AI186294, AW361984, AI940759, AI940744, AA812151, BF357542, AI248069, W86421, AW378978, BG961093, R05855, BI091087, BI091081, BG505976
Ligase1: BI916625, BM555654, BX325045, BU154275, BM044202, BM548700, AL530699, BG743952, BG678604, BU168385, BG774713, BM015149, BG825382, BG681554, BI755126, BU152699, BU543078, BG744633, AU120968, BX329161, BE747873, BM472230, BG257399, BI856896, AU143382, BE794374, BE744087, BM763360, AU120985, BG327553, BE512655, BE873444, AL570759, AL042689, BG747144, BX325044, BE047619, BQ072622, BF038182, BU159409, BM013639, CD579385, BM794429, BF529953, BQ923144, BE297514, BE263744, BQ648677, BG257587, BX362172, BG251839, BF205184, AL558263, BI765243, BM917641, BE512703, AU128254, BE294485, BQ644838, BG024771, CB109099, BQ654248, AA306774, BM711430, BG177788, BX370252, BM846234, CB270211, BI025622, BE257136, BM975458, BM819487, BE266691, BX475022, AL530700, BQ231386, BQ071175, AL710126, AL705975, AL705915, AL697933, BM749091, BI463850, AL602262, BG333926, BG116773, BE294757, BX362173, BM456382, BF797607, CB121210, BM458469, BX503423, BG685986, BM836632, BG469591, BE907368, BX475021, BM793401, BI829665
Pold p125: AL578715, BX382861, BX366475, AL560083, AL556466, BX366474, BX402885, AL525375, AL514720, BX350425, BM479873, BM905305, BQ920464, BU855691, BQ054258, BU527550, CA455120, BM008549, BQ070749, AL559084, BQ688129, BQ068026, BQ955289, BU542295, BM048573, BE311672, BQ958499, BM044191, BU859048, BI859768, BG744446, BQ936440, BU173332, BU931011, BG826841, AL580780, BU527075, BQ918345, BE737103, BM008621, CF125207, BG745091, BG472420, CA455000, BQ890540, BU154168, BI334420, BF205093, BG340726, BE798460, BI118205, BG683283, BE547846, BU185961, AL514719, BQ071299, BG258722, BE796517, CD101690, BE274988, BU844535, BE298157, BQ953920, BG390567, BE731346, CD615429, BG029434, BF346914, BG911621, BG281172, BU944555, BF206631, BE513504, BE391305, BG832159, CB321982, BG749237, BG285702, BQ343533, BF312202, BE901507, BU553455, BF304095, BU501677, CD615427, BI227211, BG120642, BE255898, BU161275, BM012106, BF529600, BQ232039, BU539859, BG115290, BM471494, BM742222, BF203965, BQ071659, BE514532, BF689201
Pole Pol2: BM799918, BX368245, CA489133, BX452508, AU124277, BX448917, BI524150, BX432893, BE613576, BX400486, BX448918, AI341337, AW629043, BX444300, BU617156, BF029073, BX280062, AW974329, AA448761, BE966475, AA709119, BX400487, BQ318645, BM784534, AI039222, BQ946037, BM454666, AW439589, BE782680, AA282380, BU742406, BM193890, AA448664, BM665497, BF738758, BF766844, BG473220, BM751106, AA333178, AW139478, AI636255, AW242762, BF766936, CA941526, CA941235, BM509588, BF766967, BF766969, BX384417, BM505194, AA812343, N53947, BF766934, BM751342, BG195865, BG185004, BX414432, BG219868, BG210945, BG207825, BG197398, BG193392, BG188146, BG195403, BG190325, BG207824, BG216817, BG216115, BG212524, BG209425, BG196918, BG190326, BG189205, BG188145, BG218864, BG203607, BG182912, BG215183, BG220834, BG216818, BG203604, BG195863, BG194393, BG194392, BG181396, BG212527, BG197926, BG195866, BG189206, M62099, BG214127, BG193903, BG192860, BG212525, BG207823, BG207822, BG204615, BG202577, BG202576, BG202042
Pole Dpb3: BX471071, AL544919, AL531155, CD171731, BX422049, BX403356, CB159628, CB152302, CA487866, BU956441, BU931411, BU844651, BU844620, BU193214, BU181445, BU178251, BU160282, BU153515, BQ956965, BQ932794, BQ896428, BQ883962, BQ691435, BQ688656, BQ643218, BQ437007, BQ425615, BQ421168, BQ227667, BQ224773, BQ220928, BQ057666, AL713425, AL711259, BM853361, BM830557, BM818099, BM811580, BM552527, BM478816, BM474837, BM465332, BM463844, BM451660, BI463584, BI224290, BI091613, BG181075, BG111071, BF978613, BE895839, BE883232, BE872164, AW246427, BE910559, BU161793, CD300569, AL542290, CB132298, BQ924495, BM920044, BM847093, BM451747, BM013495, BI668995, BG700033, BE781043, AL598822, AL550727, BM749328, BM477218, BI755256, BG720455, BG505578, BG387715, BF983616, BF978547, AL541402, BM557688, BM558417, BM193306, BG024009, BE543436, BI333822, BQ059205, BI561738, AU280159, AA524279, BM753932, BM014466, BE880199, BE242720, CD710143, BU959989, AW136187, W03622, BU571151, AI634435, AI991485, BI334810
Pole Dpb4: CD674888, BU597500, BU595433, BU594966, BM924454, BM555016, BM551010, BM009306, BG491874, AW081785, BE910607, CD107195, CA307504, BU520765, BQ233876, BM912894, BM809080, BM727074, BF237493, AI554783, AI436367, AI886832, BU597812, CA454961, BM929605, AI432454, BI667558, F26406, BQ954219, AI815728, BF025828, BE276764, BF764960, BM725423, BF107426, BG760830, BU740914, BG740141, BU077279, BU963250, BF237693, BG683544, AW970445, AA927473, AI142293, BM714678, BU739305, BM984649, BI599890, BU076938, AI797479, R07547, AI188727, BG682813, AI815926, AA513753, BP431280, BU537093, H27059, BP429067, BM677848, AA811357, BQ219306, AI833007, AI090223, AW368694, AI148002, AA676886, AA353038, AA740345, BQ640428, AI191303, BQ013037, BX112032, BU953216, AW955899, AA400317, BQ011449, BM688755, BM687694, AA368986, CD693537, AA400632, BF944449, BF378717, BE615920, BE408046, BF978324, BM723287, BM682293, AA536076, AI336523, AF202331, BG461940, AA639692, AI970899, CF529348, AI017725, AA468753, AA978356
Topoisomerase I: BU175449, BG574241, BQ918804, BQ720771, CA488073, BG506927, BM788013, BG546269, BM722996, CF137671, BX403047, BX391491, AI878932, BG493034, BU934394, BF977810, BE748187, BQ230349, BE733657, AW025108, CA487823, BE070282, BG401860, CB242988, BF912374, BG433599, BI561949, BG252538, BX406161, BI092973, CB959389, BF887734, CF145440, BG529331, BF594476, BF726053, BI087263, BG540279, BF002422, BF214159, AA765988, AA594329, R60159, AW368554, BF768633, BF923424, BF573926, D55538, BF105824, BF741104, AW854287, BF095014, AV708869, AI493041, CF127017, CD523275, AL559809, BU625720, BU195531, BQ950231, BQ718893, BG778556, F07589, BI834633, BU940860, BG169393, BE818064, BQ438538, BU429936, AI271876, BX389156, D54890, BX391490, BM541278, AA887955, BM699908, BF216295, AW368250, AW368275, AI479910, BG532987, BM720782, BF342838, BQ379859, AW003919, AA639463, BX403046, BE172121, BF924434, BG942263, BG611737, AI337284, AA987503, BF030802, BP430593, AI637947, BM985011, BF694314, BG569753, BF887735
TDP1: BM545366, BX357935, BX352942, BX368062, BU185781, BX336700, BQ214685, BQ233509, BX367994, BX368251, BQ689475, BQ049211, BU163540, CD654830, BI253420, BX388603, BX357934, BG291484, BQ277263, CD642861, BX336701, BU174608, CK000808, BE894450, BE613472, BI490906, BX352941, BM150331, BQ223905, BX472747, BX363837, AU136908, BX407827, BX461234, AW968944, BX368068, BX474790, BE387073, BE614223, BE786331, BI222338, BU429540, BG772310, AU135919, AW249271, BX367862, BU849335, BI822990, AL602103, BX477415, AL598723, BI861569, BI489958, AW962673, AL705760, BE909004, BE747879, BM712636, CA425849, BX401951, BE312937, AW849814, AW849937, BG475315, CD641965, AW007897, H49893, BQ010512, BE246145, W76100, AA332235, BF196744, BM462605, AW410205, AI480141, CD703683, BE247287, AA609339, BX475227, AA477148, AI209111, AW961554, AA330280, W72865, BU738356, AA336839, AA514317, AA620407, AW000979, AA504522, H49894, AU156926, AW129282, AA628378, AW589860, AI636696, AI989590, AA716609, AA489121, BF896143
Ctf18: BQ231004, BX447012, BM806765, AL562324, BX371387, BU553656, BE795677, AL516520, BQ962210, BQ650965, BE797877, BQ645686, BU845747, BQ646300, BE898071, BE901267, BU509771, BQ650789, BI457170, BI196074, BG481033, BI823171, BU625412, BU633872, BE888887, BI766695, AL516519, BE902046, BG168881, AL524240, BM674122, BQ648925, BQ651106, BQ646373, BM715777, BM127632, BF308850, AW973666, BG761379, BU845239, BM832965, BU616468, BF306837, BQ645867, BQ773121, BM127327, CA421425, BE262702, BU159091, BM703773, BM793661, BF513105, BM005987, BE314193, BF347314, BM906352, BE313266, BQ644028, BQ650233, BQ647544, AI831961, D61532, BG480239, BX117345, BE780529, AI650845, BE300859, AW196692, BM150350, BF093805, BQ367862, BQ073027, AA478378, AI824849, BE279389, AI620989, BU540454, AW236312, BG825945, AI918000, BE242499, AW662226, AA352175, AI355547, AI916173, BM701214, BF182688, AA610722, AI276362, BQ651661, AW149595, AW631061, BF434726, AW467884, BF091910, BG488804, AI401116, AW904596, AI689357, AI382635
Scc1: BM466374, BU146139, BU164770, BQ434145, BU190012, BQ222984, CF552154, BM474979, BM477931, AU130565, BU156118, BX390631, CD657694, CD654104, AU123599, AU131556, AU123557, BM927599, BI089741, AU124372, BI869474, BU625171, AU137268, BM920285, BM479826, AU138617, BM803806, BG779064, BG503734, AI905425, AU134242, AU130905, BU175990, BG289967, CB959416, BQ437529, BE870127, BU940947, AU135199, BQ229673, BF797759, BG254176, BU178041, CF619358, BM452576, BI093343, BE560508, AI627668, BG390625, BQ638398, BQ230670, BU509303, CD358988, BQ574279, BE867847, AW028126, BQ230181, BU181371, Z78332, BQ218011, BU598145, BF103682, CB143108, AL705581, CD557703, AU134649, AU125960, BM833822, BM749176, BM452530, BG505923, BU431249, Z78334, AI739002, BF540787, AU128854, BE895809, AL540173, AU133303, CF135927, BM907180, AU129400, BF091717, AA129353, AL558080, AL046011, BM833939, BM467920, AU135442, BF794442, AW500227, BM461566, BF590668, BE748270, AI017447, BI093513, AI367597, CB143109, AA699622, BM478563
Scc3: BQ946254, BQ224497, BG678247, AU131359, AU141951, BX643586, CA488740, AW993480, BG284625, BM468092, AL042846, BX506229, BI223205, AL582073, BQ229101, BF796496, BU431562, BG682345, BQ718426, BG114650, BE871224, AU132652, BE929374, BM799307, AL701691, AW499961, BX505839, BQ422046, BF085120, AW966123, BF085121, AW993214, AA311870, BE817052, BU430955, N25477, AW937839, AW501973, BX503773, CB988449, AL701626, BE541958, AL710194, BE817053, BF085130, BX505398, AW892743, CB963696, AL582049, BX643342, BX643410, AA179766, BI088302, CA454732, AL708036, AW999070, AW966631, BF367226, BE540683, AI064692, AL692142, AA334313, BG698257, BX473973, CD238866, BQ371413, BF330420, BE832149, BU431563, BE832148, AA385639, D78828, BE844082, AL710458, BE844095, AW993032, BX473971, BM751899, BG951313, AA249600, BG187519, AL603592, AU117247, BX102249, BX646186, BM718664, BX474425, BI771735, BM833941, AL600231, BE708022, BG536049, AI351861, BG899130, BF830533, BX437683, BG167708, H75808, BM561699, BG256800
ATR: BM452469, BU146099, BU193242, CD359676, AU133155, BQ226453, BU616550, AU138930, BU521017, CA771525, BG679313, BI259481, BE894977, BX476619, CB134903, CA771217, BU620031, BG770191, AI685264, BE221326, BU676069, BQ432546, BM855140, BX646290, BX476608, BM141700, BX476618, BM129429, BM129718, BM141963, AW769028, AA453176, AL707012, BG768017, AW029178, BG960271, BE646363, AU154536, AA746485, BQ025557, AW769551, BG960875, BE091396, BG026395, AU157822, BM796532, AI584172, BU431210, AI288527, BM459025, AA731840, BE859077, AL039634, AW976047, BF222914, AA825525, AV751232, AW390089, AW152454, BG392173, BG223235, AA551327, CD644383, BF094478, BF930497, AI962936, AI871554, AI279279, AA837410, AW978820, AI394218, AI285634, AI280393, AI127664, AI078770, AI027417, BU076885, BX497770, BG192205, BG189101, BG184889, AI088580, BU077225, AA215661, BG208865, BF110182, AW237573, BG210328, BG221227, BG201951, BG191706, BG182288, AI902747, BG194892, BG204028, BG208221, AA747410, AW390065, CD642306, AI689705
Chk1: BX384024, BX425856, BX352948, BM458297, BM803862, BX363020, BX384025, BX383978, BX363830, BX443777, BQ071454, AL515222, BQ919396, BX346314, BX363829, BX414303, BQ424951, BX345096, BM048703, BM478961, BU620586, BX386787, BX386786, BU181250, BG717056, BX440542, BG687019, AL523644, BG258170, CA441277, AI924526, BI088504, BF795495, AL708308, BG612596, BQ226720, BM968823, BG339614, BG944287, BE299090, BI521358, BX351192, BG828404, BQ223060, BF310022, BQ641604, BM558032, BG218896, BF242017, BF001625, BG470645, CB127107, BG192348, CB124258, BF204894, CB124369, BE464453, CB125201, BG256454, AL559804, BE298964, BX383977, CB124285, BG194802, CB998143, BE904400, AL559805, BG216281, BG191840, BX425855, BG215785, N99369, BG470702, BM193374, BX363019, BI197298, BE882051, BE297644, N53057, BE548526, BI824209, BG211479, BX346313, CB142976, AA224307, CD694666, BQ322635, AA962684, AI536947, BM455102, R86187, H67490, BF973418, AL515221, BF946916, N71469, AI750793, AL523643, H59530, BU927896
NBS1: BM542698, BX405940, BG182890, BU166634, BM461758, BG214621, BG388866, BG284646, CF593314, CB123692, BU517247, BU661996, BM014420, AW976050, AI796269, BG483074, AU118357, BG109073, AW978306, BG392111, CF994271, CB250418, AW183153, BF027776, BU620472, AI888159, BE694454, CB989468, BF511289, AL713597, BG292394, BI962748, BG202556, AW363125, BF028917, AI767797, BE142989, AV715636, BU686090, BE695861, AU144944, BF219376, AI478631, BF208284, AW237021, BF217323, AA535147, AL041061, AA741007, AA577530, N22869, BE694368, AA713939, BF222791, BE892618, BQ354782, BE566896, H98655, AW391193, BE694374, AW340253, BG197194, BF062731, BM835126, AI890179, AA807181, AW025671, AW593423, BE089552, BG194661, BG194211, BG187424, AA463450, BG184671, BG209170, BM833754, BE694416, BG198067, BG214402, AI478521, AA835830, BU172525, BQ380443, N36514, AI858133, AA907134, BF096050, N51586, BG196671, BU429506, BE694353, AI952672, AI377839, CF137847, BE142840, CB135538, R48068, AA535711, AW207441, BF219034
Hus1: BX510134, CD520767, AL554895, CD104810, BU933524, BU932644, BU600981, BU171912, BF185772, BG386353, BG286955, BE874516, BM462752, BU932377, BE568470, BE892098, BM546627, BF510091, BE543378, BG330719, BU193379, BG703514, BM906889, BE644764, BF796878, BM822628, BE566605, AA902233, AA280710, CA418558, BQ646867, CD678464, AI675254, AI968159, BG028551, BU680921, AI968626, AI750426, BU784416, BE891273, BF056974, AW518029, R29753, AW270395, CD357688, AI656993, BX115181, AI149713, AI538328, CB992757, AW965692, BU588470, BF222727, AI654498, AA693873, AA353895, AA828114, AA773515, AA897773, AA652723, BX500811, BF998283, AI968739, AI656972, BX370241, AW467865, BF211281, BU928301
Rad1: BX439078, BX362814, BM915064, BU508168, AU142492, BG325636, BG254417, BE739684, BU942019, CB997499, BG528822, BF305274, BU192569, BE379759, BX472344, BM453151, BG502187, CD365064, BI821006, AW779759, CD370483, BU567700, BE542464, BQ277303, BF381656, BF103945, AL697883, BG687436, BU431185, AI732815, AI870850, BE866735, AA486301, BM875591, BX362071, BU623683, CB126098, AW237104, BG687442, BF084168, BE565545, AI052547, AI628587, BX105685, CA432131, AW373219, CB306975, BU682777, BM875344, AW473643, AW473637, BM790461, BG777245, AW104439, AW001011, BF667027, BQ214495, BG108349, BQ433094, CD513520, AI685362, AI075030, CD672667, AA968417, AA029300, BF807890, BM264116, BG036263, BE843169, AW779236, AW819703, BX373966, CB218092, AA768474, BF242093, AW579006, AA464502, AA227739, BE930194, BF375637, BE549430, AA913007, BI862650, AI871190, BX369672, BX369671, AA228124, BF748944, AU157657, AU123712, BE928477, BX435862, BM015762, BE645342, BE379989, AI885817, AI734194, BG612563, AV711443, AA464501
Topoisomerase IIIb: BX424738, BX425419, BQ651682, BX403442, CD107506, BX446190, CA453925, BX346535, BX418504, BG763535, BM549973, BX403443, BX388297, BQ649447, BQ279059, BX353337, BX428354, BM562369, BX389266, BF690073, BM922961, BQ884077, BI254650, BG751464, BF348239, BG767127, BX375918, BI199856, BQ425197, BX333417, BQ939934, BG748897, BX418503, AI361851, BQ183439, BX428593, BM719837, BF689997, BG827105, BG180123, BX431485, BM020904, BX431486, BG251915, BF568363, BX430251, BM982636, BM542563, BX353336, BF839819, BX389265, BX456723, AW082912, BU739692, BM668058, AA581879, BM929485, BX375917, BF569140, BF840332, AW081400, BQ072301, BI908256, BI458744, BQ437166, BE262344, BX471363, BX333418, AI653725, BG281858, AI432376, BG910301, AI271458, BQ018902, AW594115, AW580188, BF683888, BQ052367, CB958279, BU733478, BU956077, CD656636, AA576862, BX425418, BQ925386, BG519835, BQ267454, AA789096, AI884361, BQ270362, BU194029, AI654571, AV724647, AI797309, BX088825, AI252649, AI368666, H30621, BG281907, BF971171
Rad6A: CF242862, AL556664, AL554264, AL551212, AL545489, AL527666, CD245975, BX420488, BU177002, BU176550, BU158774, BU155911, BQ938012, BM904536, BM671147, BM547988, BM460782, AL601372, BG477320, AL557798, AL552044, BU594647, BQ773667, BM127839, AU137774, BE873022, AI126625, BM128123, AL547443, AL547028, BG771586, AL561578, BU596427, BE893452, BG037200, BM128046, BM127780, AU135850, AI912983, AW051875, AA917931, BM172179, BE280929, BE504240, BF308088, AI367248, BM888354, BE465165, BI914734, BI562526, BG426078, BG399765, AU128974, BI117499, BG709332, BI223209, AU123986, AU126997, AL540766, AL545955, BQ717080, BX377743, BE276997, BG429673, AI830472, CB118540, CA398015, AU280101, AI367259, BE001808, CD673205, AU128994, BQ050943, BE934281, AA314005, BG249012, AW206875, AI984287, BM752230, AI097110, BF030505, CD299140, CB962261, BE867709, AW205767, AI371888, AI087376, BG680605, AW139418, BP431686, BM741851, BE002061, BF694346, AA442497, T80555, CB127128, W77761, AA340148, R92832, AA808831
Rad18: AL515920, AL525404, AL562493, AL515921, BM479176, AL519429, BX327634, BU633444, AU130305, AU124369, AL519379, BQ878144, BX118224, BI260485, BX644573, CD657250, BQ002046, BG403172, BG187245, BG687139, BQ438688, AL519378, AL602096, BG501779, AV689196, BG434615, BX506345, BG528199, BU928268, BM827802, CB146761, BM783792, AU152279, AI674134, BM987526, BF062100, BE538599, AW024863, AW188470, AW852547, AI140776, BM739442, AI140772, AA625471, AA628928, BM820601, AA953817, AV689200, AL600012, AV689197, BI463280, AV689198, AI075759, BQ012909, BU588168, BE245247, AI826396, AW274711, R59255, AA311754, AI266146, BE715962, AI051483, BI060361, R59197, AI292169, BQ305165, H79432, CD643305, AA972797, AW607437, CD709390, BF241055, R42938, H79318, R17601, AI262720, BQ013328, AL044563, AA494524, AI536060, R18043, R13366, AW804426, AW607158, AW969432, AA745596, R40881, BI060362, AW804432, BG992485
Ubc13: CF130960, CD710574, CD692115, CD673025, AL543503, CD245362, CB988950, AU280192, CB215753, CB161684, CB161357, CB159339, CB158868, CB147566, BX110715, CA453274, CA310015, BU959707, BU942968, BU941352, BU935537, BU787955, BU509214, BU195662, BU177345, BQ670955, BQ651546, BQ438057, BQ434581, BQ431772, BQ278353, BQ233659, BQ233603, BQ233591, BQ220048, BQ212232, BQ071631, BQ053849, BQ053589, BM927363, BM920802, BM916123, BM810273, BM805692, BM548060, BM480191, BM456876, BM449746, BI830293, BI829065, BI822117, BI753449, BI603033, BI193140, BG759142, BG758336, BG720632, BG716212, BG701931, BG613290, BG548397, BG531270, BG503962, BG432626, BF974186, AU125145, AU119879, AV758049, BE747116, BE266994, BE314665, BE207615, AW246428, CD685196, CD558824, CB987518, BU940976, BU177313, BG715594, BG715088, BG714343, BG701027, BG615565, BG504869, AW950789, AW250538, BG716471, BE262841, AW673494, CD686244, CB957396, BI197667, BE313357, CD701933, AL583561, CD385216, BU596184, BX415171, BX400510, AL534723
FBH1: BQ668450, CD518455, BM475590, BQ073711, BX350417, BM556786, BX385835, BU171774, BM462614, CA976039, AL555827, BU527061, BG682347, BQ932104, BU184837, BM811347, CD513292, BM051895, CF552522, BF792094, BQ953076, BM469767, BU856754, BU507355, AL580250, BQ672631, BM541777, BG575794, BG396523, BM019265, BI462395, AL578234, BQ710339, BQ889679, BQ706264, CF125476, CA439526, BU535409, BM916651, BM014236, BF683805, BG104902, BG385761, BX369664, BG483429, BQ722509, BQ894882, BG028476, BG422497, CD722593, BE253172, BX483033, AL558429, BE513039, BG117837, AW369165, BQ437287, BG479586, BG830784, BQ129343, BM686491, BX117109, BE541008, BE736140, CA393619, BG109986, BG913455, BM717015, BX356080, BG323256, BF684368, AA045149, BE730963, BG682808, AL044721, BF349688, AW964614, BQ951138, BQ325260, BI006637, BM707421, CB113655, BQ898291, BE378693, AW963805, AA430290, CB159047, CB161429, CA438158, BX364723, BM707309, BM699811, AA428015, AW963835, BQ129349, CA395354, CB321675, BM798328, AI459539, CA945183
Mad2: BX092337, BU509241, BQ959603, BQ440642, BQ428342, BM472395, BM472304, BI766194, BU508933, BG532327, BQ425846, BG702724, BU509710, BG614828, BG505458, BX443383, BU963707, BX325759, BU198649, BM016150, BG503527, BX404037, BG679723, BG533781, BX449727, BX346251, BE270292, BU177716, BU662541, BG530972, BG531198, BG116166, BG527529, BE886793, BF305710, BU928412, CA489378, BG503886, BE311763, BX401098, BG496604, AW950858, BE778450, BE270518, BG613007, BF034523, BG504712, BG249673, AW411207, BG501915, BF219704, BE890707, BU598703, CA489522, BG504001, BF130567, BE296423, BF030667, BG531869, BF694258, BE295856, BQ277112, BE895923, BF666701, BI560148, BE543883, AW674988, CD700655, BU659357, BG169697, BE960883, BM458351, BG615578, BM837848, BG506388, BE870543, CA488467, AA490658, BF184132, BE567312, AV715949, BF667164, BG284883, BF666681, BM450737, BU661109, CB137773, CB137684, CB134844, BF698236, BU158230, BF701297, BF240809, BF185562, BF696854, BG613188, BE738000, BG290170, BF696888, BE270517
XPC: AL537156, BQ898206, BM556322, BQ918948, BU506961, AU125870, AU130697, BE260062, BQ892451, BG751164, CD643621, CK000090, BE730655, BF981364, BG748625, BG341433, BF972749, BG338028, BU602325, BF317427, BF306190, BI255928, BE278952, BM461420, BE733920, BE252615, BG752811, BI670281, AU120699, AU130155, BE254313, BX474915, BM729318, BG340238, BF314903, AU280283, BG489139, AA287404, BG337505, AU127391, CF995178, BG335426, BQ308142, BG259049, BQ649424, BQ307301, BX505750, BE260137, BF683997, CF140093, BF685974, BX470382, BE257840, AI123414, AU150414, BQ477814, CF141168, BM827376, AA657557, BE221715, BG571695, BX475123, BF090364, BF207269, AL709045, BM856351, BX497971, BM708556, AW504862, BM833387, BG178613, BG620310, BX283619, BG749233, CB269927, CB267080, BM700758, BX486869, AU143301, BX493543, BM852149, AU128095, AA190694, BE702371, BE074001, BX644722, BG396899, CD250721, AL710884, BE262208, AW903238, BF827957, BE766460, AV736879, BG116273, AA329947, BX476805, BM454293, AV734541, BM908255
Rad23A: BX386817, BM555668, AL556689, BM923938, BX462941, BQ226301, BX383110, AL518853, BM563676, BX346368, BX443456, BX458814, AL560403, BM800629, BM546406, BM450093, BX400223, BM905361, BQ067487, AL538737, BX448989, BX376642, BU182138, BU501586, BM460305, BM455101, BM553961, BX405327, BX439481, BQ959921, BG397266, BQ231221, AL528006, BQ649073, BU161613, CD516432, CD300604, BU161547, AL527519, BU170588, BQ922155, BM922503, BM806531, BM811343, BQ878719, BX416323, BQ431936, BX424587, BQ231191, BM553778, BU166711, BQ068184, BI115640, BX336880, BE743148, BU902824, BM543659, CD517476, BX440266, BM928421, BE793785, BM805413, BU663811, BM767302, BI771571, BU543634, BI488410, BI831370, BG828123, BM702259, BG826357, BQ671655, AU120562, BI756007, AL554211, BG575011, CD359531, BI092253, BQ923295, BG765676, CF146536, BE254829, BM764880, BI768800, BE254847, BU186368, AL548714, CD580418, BQ430734, AL708410, BU598395, BU160883, BI770418, BI458425, CB243750, CD300680, BE296271, BU624195, BE792673, BF982409
Rad23B: AL542437, BU508207, CF242874, BI761813, BX385070, BX344701, BX397027, BX406219, AL544467, AL540969, BG617563, AU135170, BM785167, BG681545, CD516576, BM846302, BI094479, AL532383, AL554483, AL549735, BI524081, BI086980, AW747914, BM843069, BF949974, AL570682, BE166667, BI460482, BF696085, BG290212, BE018477, BE566434, AW117407, AW631016, AW629978, BM919879, AL516156, BE218017, AA460535, AA305019, BM845855, AW610521, BQ927520, BF082151, AL571657, AW080867, AI221288, BF239610, BF116028, BE218477, BG035090, BF238781, AW610520, BE926034, BG718045, CB995306, BM705797, AL569427, BX411441, BI868477, BF817189, AA316654, AW821231, BF433951, BF906503, AW578686, BF762435, AA932185, BG958581, CA406436, BX387819, AW389400, CA389879, BU959168, AI261824, AW991331, AW663949, BF374886, AW770657, AI703064, AW510997, BE925443, BE220051, BE674734, AW389398, CF553075, BF088680, BF762431, BF692478, BF111238, BX422214, AA359699, BF994844, BE613559, BQ929186, BE817876, BM480327, BF755677, BF795639, BX500679
CSA: BI918304, BM833676, BG611935, BM017684, BG722970, BG612963, BI458951, AI950957, BI601669, BU603353, BU533681, AA454500, AW954940, BI828404, BE540951, BF244952, BE567160, AL691658, CB160846, BG387575, AW388466, AW388282, BF206366, AW301277, BI850241, BF665074, CD687697, AW409745, W19086, BF790869, BM147057, BF665145, BG616128, BE568475, BQ218876, BX116922, AA129369, CD109410, BG032140, BG037177, BF588485, BF000147, CF552572, AA159858, BI561029, BM835908, BQ645232, AW418819, BF247700, AU100233
CSB: CD653749, AL039860, BG723092, BX644251, BX474980, BF508753, AL702189, BM759548, AL039851, BF094116, BG121679, BI020594, AU185158, BE763975, AV725351, AI418429, AU185476, CA502920, BX485503, BE841244, AA305555, BQ015647, BG259982
XPG: BX370344, AL537284, BQ215712, BM461711, BX383623, BI518401, AL537285, BG754702, CD243930, BU680238, BG574639, BQ002437, BI836225, CA503022, AW044617, BQ045373, BU608348, BG282989, CF619292, BQ014611, BI091747, BU624982, AA843311, CA418268, BM793974, AW772514, BU617777, BQ186957, BG400427, BU732780, BU608324, BQ221301, BM504121, BG391687, BG286779, BI711387, AI680931, BQ775943, AI417946, CA424453, BM875436, M797308, BE170510, AW317068, BF576042, BE552270, BM507072, BM750705, BM675983, AI885477, CB142083, AI623400, BQ614576, BM830049, BM875687, BE350942, AW854025, CD579376, BM677102, BF360483, BU740308, BQ002355, BM504348, D250763, AI768283, BG282957, AA548114, CB270753, BF515914, AW369265, AA312903, AI702437, BX471563, AA582936, AI907200, BQ215703, BM712460, AW504101, AI452675, BI459976, BE772886, AW576371, BM838528, AW401569, BE772887, AI218110, BE349982, BG723008, BM506721, AA592904, AI458250, AI272121, AW966715, AI572661, AI023105, BM831424, AI285500, AA808705, BU738082, AA506450
XPF: BI522552, CB956135, BG620282, BG181154, CF529228, BQ013114, BX503907, BQ310815, BM671280, BQ011470, AW977575, BM710111, BG724387, AL705565, BE818393, AA291199, AA770518, BE837466, CD674166, AA774566, AI431784, AA256859, AW271424, AA638976, AV685090, BE818447, AA255461, AW242081, AA723776, AV692790, BE814005, AI653508, AA721794, BX103000, AA834535, AA292809, AA808363, BI459712, AA284141, AA639091
DDB1: BM927667, BM545266, AL547974, BM559217, BM474381, BQ057079, BQ230722, BQ051604, BQ927173, BQ943701, BM799741, BU543084, BQ220481, BQ070702, BQ061047, AL521541, BU931018, BM469013, BU153954, BQ945468, BU165038, AL555048, BQ898580, BQ068618, BQ050859, BG764306, BQ057811, BU159948, BU508051, BQ065776, BM804642, BU845856, BM905933, BQ935651, BQ060859, BQ052770, BQ066316, BQ066118, AU125547, BM803322, BQ927550, BM552236, BM473607, AU121686, BG746666, BU535682, BM556709, BQ931953, BG831447, BG751027, BG677450, BQ683506, BQ642180, BM476800, BQ063089, AL549443, BM553844, BU178933, BI256821, BQ059091, CD652436, BQ962485, BU542556, BQ061252, BU156588, BQ642770, BU501977, BQ897254, BG762513, AU140587, BM046600, BQ070862, BI260236, BG747001, AU140248, BU154345, BQ060945, AU140289, BE743760, AU130230, BQ056360, BE794022, BG327224, BE747530, BI457215, AU140521, BM456004, BG481963, BG469259, BU943325, BQ943596, BQ213497, BM043469, BQ439584, AU140209, BG769813, CK000424, BQ279191, BQ438774, AU140418
DDB2: BX401847, BX400795, BM460187, BQ688926, BM563807, BU159281, BX384437, BM008599, BE792938, BG479004, BQ940060, BE797218, BM560871, BX117885, BM018420, BM455897, BI256001, BX360369, BI868487, BX385303, BE799933, BM009575, BM553220, CA487463, BU174903, BX366945, BM850079, CD518332, BI915455, BG756997, BM782789, BI915534, BM554617, BG118313, BE261143, BG913101, BE783395, AL566516, CB142981, BG035565, BX403426, BI838828, BG756904, BE885720, BX400794, BE018683, BI761524, BM746344, BX363265, AW247981, BM743623, BE536472, BE903342, AA309052, BG612441, BQ063694, BM744890, BX384436, BI255783, BM791178, BM924491, CD696204, BG106780, AL536826, BQ062583, BF974680, AW803143, BM783399, BF791778, BG759533, BX366944, BF974639, AL702736, AA278480, BG613246, BM840145, BM821166, AA311506, CD685541, BM920389, BF375336, BF576398, BX360368, BX384709, AL702729, BP431548, BI092193, BF382434, BQ001750, BI261116, BF184818, CF144601, AA128445, BE798846, AW802999, BF203187, BQ001644, BE247271, BQ003952, BQ575065
XAB2: BX356659, AL518679, AL519886, BX424193, BM922374, BX381810, BX381811, AL557238, AL535342, AL525436, AL538943, AL518678, BX342559, AL565880, BX397557, BX383379, BX383380, BX382204, BQ053451, BX383814, BQ643137, AL561830, BQ050225, AL519590, CA488373, BU845857, AL560324, AL521338, AL534944, BX370726, AL560477, BQ935369, BU153161, BM476327, BG488778, AL516161, BX336874, BX392023, BM806807, BX364648, BI771923, BQ927835, BG488879, BM917523, BI822736, AL514374, BQ227702, BU541210, BQ221081, BM451911, BI772072, BX446010, BU855544, BU179797, BI823391, BM913999, BX448905, BQ054530, BG744221, BI910746, BQ956926, BG480524, BI261656, BM469671, BX464425, BI767323, BE253641, BI768994, BG386812, BQ063543, BI911058, BI518767, BE799838, BQ212885, BI459403, BU528530, BQ073165, BM048645, BE898732, BG468301, BE531308, BF311851, BI561194, BI560801, BF569424, BF686448, CD672626, BG425290, AL559075, BU170853, BE728374, BE871613, BE274104, BF314780, BE280310, BM456485, BU856266, BM020680, BI911907, AW837892
UNG: BM926584, BM799989, BX438441, BX342506, BU165625, BU943452, BX378897, BM471137, BM928006, BQ228775, AL559968, BX379137, CF551970, BX378357, BX372231, BU161952, BU176423, BQ882986, BQ420300, BX361226, AV705903, BM919577, BX440252, BI823926, BQ048928, BM458045, BG105781, BQ962046, BU187892, CD643361, BX366166, BM541301, CD512104, CD686190, AU126319, BM718553, BE793197, BM449708, AI879177, BX429498, BE902908, BQ950839, BG326541, BG389571, BM012071, BQ670076, BF342799, AA290918, BG392330, BM799653, BX368057, BE734542, BG717638, BI198939, BI226322, CA454788, BG176725, BX347126, BE882172, BG256273, H09366, BI226401, AL079771, BE781768, BQ348703, BG390499, BF701762, BG176633, BE559523, BG282433, AU279887, BQ365552, BE883671, BE270595, BQ917973, BE258817, BE546123, AW401453, BG106747, BE268637, BI259016, BU168154, BX346912, T78215, BG481771, BX346928, CB130269, CB129289, BE261638, BQ348874, AA573859, BP429782, CD672939, BM751245, R25268, AA356048, BI766031, BM825376, BE263990, BQ322779
MBD4: AL556619, BX372087, BM459663, BI767663, CD105484, BG032353, CD367008, BM690016, AL549313, BQ722669, BE561716, BI521142, BG032516, BI765468, BM465252, BI823689, BG686312, CA773665, BG716078, CD364595, CB989176, BF446103, BE622249, CA943572, BM314436, BI596708, AW964068, BI820928, BF033618, AW073379, BM857488, CA773226, AA741175, CA395073, CB136245, CA867841, BE541307, CB995679, AL578833, BM749974, AL553305, BE614377, CD557525, CB158348, AL553419, CB243592, BM462436, AU138081, AW138783, BU789775, AW193960, AA167425, AW195025, BG621850, BF509234, CA390195, BQ005967, BG613448, AW958704, AA939068, BF509053, AA167418, BU619480, BM476709, BM314740, BI462718, BM015493, BI544324, BF109031, AA905592, AA648364, BF109027, BF515981, AA167414, AI682256, AA011232, AI225045, BU153530, CA487592, BM857715, AA954283, BX390695, AW474165, AA825707, BI517400, BG742246, AA353798, CD678412, BG031116, BU732453, BM836637, BM709307, AI217321, AA247185, AA618259, BU678959, AW959666, CB144059, BI669635, AA171632
TDG: BM479641, BM905541, BX370775, BM456725, AU128073, CD652973, CD657696, BG621267, AV708234, BE779060, BX331941, BX483618, BX382383, BF033788, BM476558, BX385505, AV649391, AV649244, AV649186, AA477864, BE181979, BX338343, CB145292, CD642813, CD644103, BM729260, BI760123, AL600750, BX509348, BX492385, BX476996, CD110168, CB994452, CB961815, CB267807, AL701375, BM915474, BG114997, BF002914, AW590228, AW502250, AW136393, AL120270, AW051610, AI916834, AI868982, AI767246, AI669518, AI493141, AI360256, AI352697, AI332786, AA306938, AA257018, AA143198, AA131695, AA316331, CD109607, CD109351, CB989389, CB959951, AL699594, BF674842, BE502468, AI769788, BU566171, BX366012, AV654940, AL710869, BE784882, AI272154, BX340488, T34101, AW408102, BM457221, BF001989, AW138490, AW135094, H14409, BG940420, BU564446, AI869223, BE536675, BF241047, BE882613, AI435880, BF195990, BE080436, AW955279, CD050602, CA406412, AI272147, AI338205, BX646789, AA356499, BM556682, CB047650, CB047649, AI937774, AA360035
NTH1: BM553336, AL536460, BM921161, AL566343, BM803928, BM472681, BG760523, BX438358, BM019398, BQ052788, BG821962, BI868261, AL545181, BI199103, BG766177, BI832477, BQ216562, BI757515, BQ431466, BQ052774, BE799423, BG519584, BG490410, BG747350, BG472059, BE746343, BI839163, BI196060, BG468596, CA488808, BF794685, BU182347, BG388749, BI226382, BE792632, BG248655, BQ881995, BF525435, BE797167, BM917598, BM451836, BF315844, BF312887, BG468607, BE790928, BG114969, BF337743, BE878633, BM677868, BF205470, AL545152, BQ958991, BG827031, BE266472, BE314558, BM811237, BF219845, BM831407, BX445525, BM424115, BM916696, BE313626, BG678320, BE262196, BF220231, BG331307, CB142490, BQ647925, BU622908, BQ575671, BF303821, BE891721, BE744813, BG468617, BU535559, BU634434, BM982354, BM129563, BE250955, BM821556, BM851724, BM725444, AW246140, BG469318, BX444894, AI610226, BX379864, CA488850, BE256091, AI818303, BU957532, BM129299, BM831443, BU902454, BF002443, AI968475, AW732463, AI424835, BU849457, AW103041
NEIL2: BX401292, BX418848, BX386695, AL529804, AL530971, BX341864, BG759722, BQ942628, BG697467, BX427919, BI522685, BU158642, BX386994, BX333648, BI224185, AW411371, BE887573, BI113772, AL555248, BF305600, BI522781, BI520072, CB112109, BG700461, BM466367, BI601338, BU189576, CF145781, BM011284, CD558091, CF147070, BE736612, BE736412, CF139009, BF346473, AL524751, BF932051, CD671249, BF241652, BE153549, BI962581, BI793306, Z43722, BX340965, BI548326, Z46109, BU165567, BU193072, CB126915, BM729333, BM450046, BI789116, AI968247, BF761462, BF529055, BI793006, BU168329, BE153640, BI439197
NEIL3: AL528028, BU170388, BX391576, BM458786, BU173488, BX112923, BQ687469, AU133212, BQ054308, BQ220911, BX348730, AL528027, BF700528, BG397668, BX391575, BE885006, BG026947, BF664630, BG758440, BF030084, BG495300, BF103925, BF217043, BQ441413, BE882646, BE865481, BF183915, BU689565, BG122779, BQ422423, T85431, AA373561, BG388415, AI307746, AA815079, CB145683, AU154583, AA677552
APE2: BX325338, AL556617, AL519979, BQ277791, AL561128, BX395132, AL531548, BX433301, BQ050352, BM541964, AL559217, BX385097, AL528954, BI093915, BU931498, BM016132, BI859309, BQ921050, BI086544, AL582410, BQ428526, BE531337, BU553240, BM015733, BE737187, BI767790, BU184166, BU164122, CA495324, BE794688, CA495346, BI196397, BI912615, BX325337, BI669515, BQ229782, BM807966, BG709216, BX382166, BI333249, AL527692, BI909503, AL561839, BE616906, BM016478, BM726096, BE547006, BU942097, BE885110, BI837686, AL527693, BG024450, BE794496, BI915874, BX452361, BI911544, BG752268, BG386237, BF203315, BI858986, AL578831, BX394096, BI859870, BI256178, BF308964, BF310943, BF307805, BI223857, BI160978, BI160236, BE548576, BF981813, AL580878, BQ328004, BF931957, CB993692, BE280661, BI033411, AL711190, BE729174, CF146056, AL564091, BM682530, AL528953, BG438154, BX374269, BE265083, BX392349, CD366445, CD514757, BE795242, AI547012, BU540750, BE076387, AI547003, BG897167, AW386829, BI094006, AI907885, BF792036
PARP1: BX425285, BM474368, BM473858, BM458759, BM458491, BQ216584, BM468375, BU164317, BM924278, BU149272, BM474022, BM905935, BG281447, AL542989, BQ946216, BQ918876, BU849139, BX438143, BX443246, BX420713, BU166033, BM012504, BM454330, BQ438889, BI091452, BX395490, BU844993, BM472955, BM555163, BX368206, BU171470, BM472260, BG280821, BX464445, BI833606, BQ882633, AU124412, BM463285, CK000195, CD653823, CF552559, AU124072, BE740909, AU131873, BQ213230, CK000758, BQ954235, BU156802, BX460089, BX450439, BI253230, BM450940, BM478605, BI334768, BQ222114, BM805846, CD651914, CD108986, BX462212, AU125041, BQ708310, BM043633, BM452637, BX388560, BM012492, CD521009, BF976506, BX431987, AU138067, BX421686, BM469381, BU942653, BM545681, AL517083, BG499313, BG533818, BU177793, BE270913, BU178223, BI908423, BE783663, BI087079, BE270845, BE899131, BE561235, BG177824, BG031594, BG393066, BE560200, CK000604, BE744678, BM799547, BM453457, BI093436, BG259918, BQ691997, BI113824, BG123019, AA401836, BM472073
PNK: AL577752, AL542181, AL529432, AL578082, BX440754, AL529433, AL531397, AL563677, AL563673, BM552937, AL530233, AL555192, BM811617, BI523512, AL562615, BX385339, BM047190, AL582405, BI761490, BI765355, BG519795, BU957084, AL518252, BU541073, AL561123, BG912156, AL531398, AL529487, AL555795, BI488573, BQ943952, AL518253, AL555631, BI908075, BF971606, AL525997, BX331554, BU552518, BF314736, BI522840, BE312745, AL530223, BM011630, BI489474, BQ219713, BI766984, BI199796, AL519579, AL563456, BQ877856, BI834426, BG252407, BE799855, BQ055605, BQ067892, AL519578, BF315056, AL042657, BU956990, BI820868, BM045471, BM710277, BE394572, BG330783, BI909140, CB529741, BU527521, BM974879, BU619715, AV655619, BM917371, BI907002, AL526117, BU543115, BG118159, BE313034, BM982849, BI599430, CA425985, BM910694, BQ772660, BI770327, BE734945, BU622816, BG939419, AL525953, BI116338, BM923265, CF594119, BI822801, CA439970, BI827695, BE272050, BM819357, BE266096, BM687914, BE260690, AI984026, BX279591, AI830883
Polb: AL572526, AL547658, BU157194, BG743462, BX383155, BU166001, BG251605, BI761008, BM790436, BQ430835, BQ434342, BG032291, AL705932, BI753835, BI915120, BI559405, AL558615, BX646755, BE394043, CD641318, BM928122, BX395185, CA314334, CD671591, CA313995, AU121247, AA916271, CD579745, BF131951, BQ188410, AI654868, CA439409, BI598628, AA130183, AL580395, BG506123, BU188474, CB125716, CB141008, AA172068, CB130159, AL702696, AA706903, BG025809, BU933432, AI827117, BM852849, BE280856, AL702481, AA172228, AA130175, BF693388, AI124907, AW957764, AW102789, AI825920, BM725613, BM678092, BX115761, BU934294, BF245489, AW070694, AI014834, BQ053443, BI461358, AW402160, AI689323, AA315716, BF219035, AI034273, AA856902, BM931013, BM684499, AA977230, BG339593, CB144384, AA809775, BQ574627, BM979958, BF590500, AW269977, AL120608, AI128173, AI057605, AI032461, AI017499, BF507649, AI087793, AW887363, AI949400, BG196141, AA723600, BG209074, BQ186692, BQ184899, BG212204, BE889161, CD110437, BG220062, BG200837
MSH2: BM479882, AL528268, BX461033, BM557852, BM457765, BX431195, CD247876, BM543463, AU125214, AU125592, BQ878410, BQ225922, BI256610, CD655479, AU118136, BI090516, BU154902, BG756122, AU123630, CD656123, AU133361, CD519566, AU133333, BG773440, BI769598, BU178986, CB955666, AU131598, AU124367, AL563106, BX436686, BM475467, BI093054, AU120648, BU182908, BE792530, BQ223894, BI757481, AU131477, AU124664, CD656999, CD652376, CD657313, BG716960, BQ431632, BM834569, CD557029, CD693039, BE778241, BU934097, CD653693, BE779907, BG773429, BQ643544, BQ422633, BG388582, BG759539, BE894244, BG721947, BE268484, BE297145, BF033549, BQ221216, BI561347, BG773147, BE870260, AU123223, AA502616, AI792246, BX436685, AU126323, BF205395, AU144782, AU129482, AI823868, AU151529, BE254661, AU123102, BQ334510, BX413346, AW951649, BF834144, AU129404, BM788022, BM455023, CA843563, BU620631, AV693408, BU600314, AA287480, BE897216, AW402832, AA219060, AV732547, CB135442, AW003984, BE550379, BG499470, AW515731, CB143683
PMS1: BX353664, BM479838, BX328949, BX327629, BM553209, BX117693, BM800196, BG193431, CB157373, BG168340, BQ429685, BX435290, BI464618, BG536475, BM723144, BF666456, BG163660, BG776017, BX452128, AL043809, AW945172, CB161021, BF699885, AL705101, CB131671, BG292439, BX419980, CB136057, CB268969, BG120880, BM677668, BQ771615, BF978494, BU599098, BM742128, BI545790, BG401461, CA415469, AI811371, CB852984, BG827501, BG719470, BG772717, BU623174, AL043785, AI458470, BE779274, AI636100, AA278390, BM820659, AI076038, BE350913, BG222592, AA781041, BX353663, BF056020, BG716188, AA833518, Z36291, BM009631, BU597828, BE350907, BG614286, BI438347, BM996496, AV730735, BE972698, CB144057, BF210947, AW269877, AA573397, AA393893, BQ574496, AA573406, AI660351, BF570703, BU854630, BG196186, AI367805, AA210907, AA393809, BG215472, BG207030, AA092955, AI277404, BG195153, AI278080, AA297925, BQ220187, BG182167, AW661801, BG209122, AV732009, AV731296, BP431712, AI828829, AI655707, AL600680, BU561560, AA282075
PMS2: BQ951503, BM474394, BU153042, BQ881303, BU178449, BQ069438, AU140605, BG829980, BQ644101, BG720607, BQ436841, BU153051, AL708946, BU622416, BF568181, BU171754, BE884933, BQ221907, BM012037, BQ369274, BM701781, AL699728, AU280501, BE763779, BF840656, BG177103, BQ045117, BE304459, BX385541, BI548246, BM669686, BM144251, BX283912, BF674494, BU193656, BQ775383, AL701903, BQ232687, BI544939, BX283370, BM967072, BM148437, BE090126, BM967300, BI912345, BG565558, BU665027, BM147147, BX385540, BE090067, AL702122, BF114739, CB111334, BG708195, AA151500, BI752285, BF697242, BU934799, BU728992, BF381825, BM698903, AV655809, BQ322673, BQ050630, BG776255, AA428236, BU604958, AI096500, AA256227, AI147872, AA256169, BM893955, BI037161, BF840055, AI539402, BM893782, BX095320, BQ221253, BE675175, BQ368913, BI829104, BE676031, CF124711, BU622696, BU620584, AI831722, BQ644699, AI341574, BM714146, BQ129192, BG398558, BF216419, AA297413, CB306237, AA707711, AA458667, AA206606, AA078218, AA418026, AW968473
MLH3: AU121422, BQ878851, BQ716451, BG499557, BM551767, BU939998, BU183004, BM019183, CD103565, BX105329, CB118745, BM272299, Z78340, BM910096, BI752941, AV716905, AW340308, AW362032, BM738947, BE702562, AA679054, AA910059, CD701194, BM977366, AA766226, CD691614, BF540730, AI694991, AI792373, BG531828, BF207616, AA128984, H14680, BG119667, T08142, AV763342, AV764126, AA128983, BF364343, BQ002635, BQ008613, CA423918, BM792789, CA417441, CA418772, Z78339, W90440, N28386, D59901, R24851, BM684959, BM931907, AI685618, BG621929, AW007533, CA440408, AI768447, Z42933, AW385347, AI743250, AA649171, BF593505, AI683070, BQ316181, BM989024, AW896052, BM021521, AA682848, BQ428064, BM021241, AI768554, N99774, AI769320, BF197240, BF475901, BM023592, AW814434, BM146299, R20012, AL709475, BM023291, BF197600, AU147242, AA043269, AA043268, BM148801, CD678743, AI147056, N20033, AI825216, BF507953, AI934949, AI452776, W90107, AI857356, N71335, AA403079, N71385, AA249090
Exonuclease1: AL561030, BX416336, BU159140, AU124774, BU166252, AL582335, AL517937, BU190454, BG762651, BG764476, BU179240, BU163048, BG120654, BE780022, BE260617, AA486526, AL043793, BE385439, BM788680, AL517936, AL530611, BG111229, BM837022, BX280790, AV712138, BU616763, AL530610, CA419695, W79628, BF793400, AW390232, BE538507, BU178737, BX437336, BQ576087, BE082055, BM988542, CA446317, BQ776150, BM983504, BU617051, AW390243, BQ015148, BG251725, BU619316, BF435309, CD644038, AI693533, AW665143, BE464836, BF240758, BM479145, AL043794, AA489549, BM465399, BF478070, AA703000, AW977979, AI768937, AA485938, AU148568, BF979589, AA122095, AA122096, N74770, W79484, AI653837, AA972063, BE737930, AI968408, AA578654, AI859579, BE738387, BF870905, AI683464, AA812220, BU623456, CA430743, BE154204, BQ012304, BE274208, AI357911, AA485921, BF870910, AW663404, AI005418, AI023645, AA622919, BE085798, AW080921, AI040508, AI084836, AW664078, AA909643, AA832160, BI494500, BI494499, BG527833, BX470325, BF435984
Poli: BX360120, BX370036, BX329075, BX436380, BM453196, BX370037, BM470558, BM450274, BG428228, BG532401, CD642641, BX378703, BG564733, BQ316794, BX360119, BM788353, BM714817, BG724156, BI560521, AA156839, BU958811, W60418, BG678675, BF219796, BG718281, CA431039, BI465231, BX378704, BE895738, BQ438265, AW852908, AW247603, CA418634, C18134, BQ086307, BM979833, BQ429462, BM918353, CA447232, BQ365259, CA446505, BU688625, C18844, BQ365051, CB243862, BU624232, BX386327, AW974469, AA878207, BQ102388, N57090, AA812734, AA856713, AA156602, AW418676, AW857684, R37923, AA648538, BM559425, AW150751, AA383550, AW880052, AW269829, AI634894, AW468818, BF111492, AA825419, AW070469, AA890447
Rad51: AL541688, AL524788, AL530472, BQ053625, BM808716, BQ070341, AL526587, AL526399, BU182612, BX364160, BX349297, BQ438308, BU553012, BM910438, BM558629, AI347079, BM810067, BG826929, BG774318, BU508719, BI827729, BE262785, BU164989, AL563696, BQ278437, BE256767, BQ424388, BI826961, BF969466, BM804639, BQ918872, BU624430, BF311612, BF313593, AU118946, AL563755, BF970732, BG325079, AL524787, BM791694, BM018810, BG338607, AL530290, BE312219, BM011814, BM745228, BE883694, BG474115, BU931527, BF982698, AL526641, BG420079, AW732525, BF203788, BM557367, BG480368, BM972210, BE514829, BF684891, AU123935, BF313295, AL569030, AL526670, BE394150, BI197901, BQ070384, BG469700, AW006523, AA568782, AU145391, BG774691, AI419710, CF139164, BE280848, BI193363, BG470554, BM147841, BX475529, BX494877, BE890859, BU596395, BM555611, BM796675, AI670798, BQ224221, AW103435, AA873056, BE779265, BX475478, BE926933, BE186007, BQ316481, BQ316480, BF683589, BF764274, AI018041, AW392597, AU100170, BM145097, BQ316451
Rad51D: BX443779, BM915550, BU681257, AL559564, BI915527, BI254468, BG829674, BI823883, BM476837, BU521767, BQ961661, BI916871, BG475664, CD387861, AI692982, AA707504, BX327473, AL581158, BE382759, AL597240, BI915277, AW631291, N57184, BU786480, AU098391, AA352205, AA868613, BQ576251, AA868612, D59413, BU784751, BI561390, BX111725, BF905526, CA423187, BF905698, BM559794, BE827486, AW948521
Xrcc2: BQ068576, BX283699, BQ430896, AW795339, BX490624, AL575509, CD365380, CD364971, CD299443, BX452455, CD103503, CB998612, CB241699, CB161449, CB160341, BX112725, CA436504, CA433495, BU681335, BU677265, BU508799, BQ771572, BQ229516, BQ217842, BQ030362, BQ028254, BQ026904, BQ017903, BQ000324, BM992214, BM710721, BM707110, BM353061, BM312475, BM054681, BM047586, BM023098, BI911022, BI907991, BI222447, BG621955, BG259639, BG121288, BF695702, BF573900, BF475941, BE962487, AV713355, BE768228, BE768138, BE716250, BE674520, BE617958, BE617517, BE243767, BE046093, BE044165, AW856234, AW795333, AW469111, AW338249, AW272847, AW192175, AW152595, AW081629, AI921359, AI866980, AI859056, AI812052, AI807730, AI761522, AI693828, AI636343, AI587436, AI469779, AI458271, AI423414, AI401226, AI357497, AI347767, AI346854, AI346825, AI343926, AI304763, AI304314, AI299263, AI223196, AI222728, AI220037, AI219853, AI140511, AI125306, AI094986, AI089590, AI051303, AI021980, AI018616, AA928999, AA782270, AL574032
Rad54: BX403014, BX333113, BX363903, BQ277879, BU552753, BU932120, BX363304, BU553867, BX402970, BG679516, BU170678, BU173543, AL520104, BX414817, BU160045, BU932121, BQ225695, BX403013, AU124617, BG471582, BX363902, BI819429, BX363303, BG393630, BX386730, BU553362, BQ048878, BE797412, BG763599, BG258318, BF689785, BU855314, BM789908, BM720371, BE378872, BE397391, BE270285, BG768944, BM739336, BG030016, BX414818, BF304094, BM795109, BE742863, BU633988, BQ224151, BF308260, BM821481, BF663661, BX483240, BG323434, BF690175, BE614490, BX329613, BU634286, BG740710, CD696837, BE872543, CA414068, AI818766, BM754736, AI061463, AL040507, BG395239, BM773411, BM825772, AA313874, BG944997, BG827295, BU934008, BM772100, BF769132, AW516286, BM745768, BM765732, BG720800, AU148441, BM746228, BM678712, AA227600, AW236802, AA582917, BG114710, BM753165, AI990748, BM753679, BM745825, AA724587, BU849113, BX106292, AL520105, BI255111, BE613982, AI372035, BM857179, BF913956, BE708827, AA227900, BM801845, AW003486
BRCA1: BQ679749, BQ068830, BU194336, BU155689, AU122476, BM452288, BQ683955, BU552955, BU163307, AU142729, BQ878445, BU171200, BG681276, BQ676829, BU163141, BQ681242, CF121736, BQ422380, AU125312, BF508987, BF791668, BM042892, BU147444, BQ677666, BQ215100, CB155501, BG178466, BF983078, BG777447, AI992040, AL704228, AI589028, BF794879, BG257190, AL135363, AA608570, BG530796, BM800251, BM042282, CB118225, BE264293, AW295197, AW968546, AA205436, BE043993, AW968720, AI915085, CB158976, AA804632, AW504244, AU148997, BE018878, BE206562, AA702344, BQ214737, AW514868, AA812019, BE564528, AI684595, BU617173, AA486004, BU679389, BX102233, CB150491, AA814998, AA484941, CF142324, CF138586, CB136844, CB108172, AA773331, AI680547, BU677011, BM755214, CF596982, CF143993, AA111870, CF144118, AI040685, BM988066, BF447679, BF028959, BQ308670, BX644276, H90415, AW673569, BM755305, AA086435, BF795489, AW408596, BQ378479, AW575729, BQ378695, AW964452, BE560149, BX497486, AI217721, AL043576, AA205474, AA917008
Ku80: AL542654, AL537322, AL556485, AL552210, BM927751, AL557736, BX418952, BM801948, AL541582, AL516832, BX425176, BM905671, BX458362, BU193782, AL540737, BQ679008, AL550730, BM471778, BX446693, BU146999, BM560171, AL548391, BQ213485, BQ220595, AL542266, BU542616, BQ651471, AL541946, BM803480, BX439845, BQ899268, BQ672013, BM800555, BX419500, BX415043, BM543372, AU131739, BQ679661, BU188691, BQ059109, BM451420, BQ880232, BQ645929, BM467250, BM453905, BQ650072, AU142506, BU188386, BM451883, AU124221, BU168862, BQ649861, BU170704, BU155107, BU146251, BQ226372, AU125704, BU177113, CF552735, BX439846, BQ424597, BM549064, BU509423, BM809313, BI259161, BQ878391, BU158765, BQ226911, BX421454, AU119267, BQ898623, BQ425827, BG827810, BQ642849, BU177743, CD107663, CF265072, BM466124, AU141293, CD243745, AL575698, BQ921196, BQ427943, BM470728, AU131108, BG576028, AU131971, BU150184, AU132099, BU176974, BQ223936, BX447056, BU153309, BM466876, AU132244, AU122435, BQ229983, BQ881903, BM454471, BQ924231
XRCC4: BX362079, BX340876, AL543920, BM471375, AL551668, BI760531, AL558342, BI770803, CD580212, BG682493, BI758185, BG699970, BG505339, BI822602, BI463813, BG772422, BM465969, BU664243, BG776379, CA394395, BI464058, BQ226357, BI828556, BQ233170, BF183927, CB962180, BE748849, BE748380, CB146884, BF211589, BX281210, BQ421318, AW950192, BF572503, BM846671, AA314379, BF669890, CD706606, AL580186, AA447878, BX279574, AL575167, AA258143, CB144620, BG500252, BF247013, BG499117, AA448976, BF107431, BF214359, R19860, AV717223, CA453949, BG497598, AA065267, BE254850, BU171074, BM564730, AU099389, BE781259, BE780721, BE778165, AA398779, BE781955, BE783342, AA398935, AV743689, AL570210, BF895164, BF242563, BX362078, R14027, CD358588, AI795996, BG282107, BG206341, BG204714, BG199056, BG193494, BG219448, BG218328, BX389897, BG221405, BG208423, BG204713, BG201112, BG196512, BG187196, BG192946, BG214239, BG211030, BG208424, BG203200, BG198531, BG198530, BG186701, BG186093, BG181983, BG213659, BG214740
Tin2: BM911894, BQ941808, BX398174, BM915062, BQ066985, BX430064, BX347075, BX387627, BI837194, BQ423479, BX347045, BI871294, BE747943, BX429614, BX347087, BX337436, BU942629, CD244144, BX388585, BF793349, BX346850, BX388520, BX423719, BX367761, BG420146, BE903807, BE727299, BX388767, BX428959, BX430065, BX326045, BX346831, BX355414, BX428954, BX367991, BI193188, BX388709, BX398173, BX394341, BX442338, BX326233, BX432669, BQ707785, CK005692, BE562849, BU187043, BX429889, BM541314, BX444001, BX474320, BX386120, BX355792, BX395024, BQ218393, BE408455, BX381411, BX423718, BQ222471, BF125394, BE410701, BX388630, BI909268, BX374920, BX375500, BX368189, BF125791, BM549897, BF125418, BE743717, BX333804, BX450403, BI754471, BI760932, BX388787, BX356844, BI518422, BI488522, BQ707493, AA428113, AV686147, BQ720769, BM545840, BE383960, BI764031, BI767028, CB216205, BG824273, AW402903, BI835774, BQ707958, BM452819, BI833476, BI755739, BM919172, BX326360, AV693747, BI116486, BX368042, BE882159, BI821458
Sir2: BM544569, BX445007, BI834120, BM547962, BQ228980, BU507144, AL550142, BX367337, BQ072979, BI766740, CD624348, BQ052789, BU182713, BQ068262, BM920249, BQ951302, BE379525, BI862361, BX375262, CF264878, BF528797, BM462565, BX340941, BM806242, BI518634, CD515474, BX453795, BU195684, BQ068338, BQ058696, BE798693, BQ645221, BG437042, CD517619, BX380923, BQ068347, AL519386, BU197397, BM903578, BI554088, CD624352, BQ221442, BM473470, AL533183, BM924936, BI766260, BI918160, BI762157, BF034485, CD674710, BQ653076, BI603360, BG723057, BG339784, BM546244, BQ929517, CD624347, BI523850, BX428185, BG339736, BG468891, BG386360, BI838558, BI771058, CD624353, BF345522, BI823957, CD558177, BI766390, BI768954, BI768415, AL549311, BI907256, BM906233, BG819884, BI910251, BI760600, BI517372, BM805816, BF529638, AL561653, BQ430510, BQ339694, CB150996, BF975840, BG032959, BF531032, BI756237, BF975705, BU196170, BI763858, BI918541, BI524122, BG332544, BG328012, CD624351, BF686436, BG288542, BI838925, BE867361
MGMT: BU931774, BU859113, BU172662, BQ641434, BQ220709, BI771279, BI520278, BG753063, BU850242, BQ228817, BQ710379, BI520938, BG764104, BX094941, BQ279107, BI226276, BU858086, BX509195, BM759902, BI520029, BU154192, AL520114, BM974121, CF130478, BM738844, CB992752, BI772512, BG436862, AL520115, BM973348, BG249568, BI520980, AL524961, CB993639, BM009017, BU845865, BM970224, BX373012, BU616455, CB055208, BI225271, BI333401, BX376972, CB055209, BU947266, CB997161, BE858532, BM972582, AI719186, BM670373, BU845870, AA978354, BM744653, BG340352, BQ222473, BM758658, CD369999, BG183775, BX351398, BE541556, CD249663, BM744647, BU737340, BM754382, BG181704, AW168149, BM712082, AI963126, AW274265, BF109578, BE464809, BM711175, AI016474, AA126722, AI143841, AA948354, BU786059, BM049297, AA779559, AI052155, W58681, N95214, AA988766, BU566480, BX349121, BQ072274, AI057145, BM823702, AI040746, W25247, AA677158, AA136191, BX383619, AI123988, R72558, BQ217761, AW804292, AA565025, BE774145, AA868690
DUT: AL576853, AL519489, BM757904, CD247125, BM457507, BI091680, BQ440183, BM915011, BM740990, BU600705, BE386365, AL532465, AI686520, BM475441, AW968574, BF338018, BF206146, AI680930, BG682494, BI836025, BE221492, BI255334, AI951891, BI868234, AW968748, BM470935, BG700386, BE897174, CB529208, BU677683, BU677665, BU620392, AL554011, BQ777742, BE254729, CA777885, BU597092, AU119115, BU623296, BG717317, BG655751, AW162006, BI670458, BG705392, BE902236, BG717215, BG53201, BG610639, BG677850, AI635074, AI261871, BI091131, BG163981, BG113287, BE706306, AA056738, BE644721, CB110414, BF317403, BE551158, AA737006, BM554499, BE222283, AL532464, BM840182, AA256721, AI373097, AW629827, CA778151, CB117412, BE549576, BG505144, BE218639, BF058963, AW341118, AW967946, AA278799, BE504213, AI191219, BI860728, AW962792, AI697600, CB137303, CB133275, BE502892, AA291243, AI199667, AA446533, BE673841, AI937879, AA434589, AI986329, AA433910, CA488337, BF938984, BU608498, BM559498, BU683317, BG403290, BM817453
TIMELESS: BM467715, BM927658, BM541298, BM801216, BQ052552, BQ945096, AL560919, BQ068552, BU845242, BQ071352, BU930918, BU854737, BQ068451, BQ961203, BQ055183, BU500665, BX390921, BX401304, BQ962781, BQ672871, BG749383, BX346012, BU521442, CF242984, BU552412, CD653932, AU125640, BU543485, BQ927368, BQ051381, BI222498, BG822789, BQ944034, BM046877, BU146750, BU956003, BQ670516, BQ061549, BG757741, BE797452, CA430803, BG819936, BE746308, BU187951, BE794062, BM013386, BE795708, BU553769, BM552373, BQ424129, CD654639, BM910771, BG388233, BE729276, BM013167, BE791318, BE514198, BM740568, BX350660, BG110568, BX110927, BI087328, BQ958679, BE727460, BG823400, BE729002, BG289919, BF971197, BM048813, BE514731, BE314800, BQ887260, BE745259, BE408808, BE208475, CA489086, BG478136, BU188642, CD673319, BE389356, AW382754, BE793649, BQ214512, AW383633, BM793905, BM789297, BQ221649, AW383534, AW673493, BM018763, CB990372, AW383548, BQ937242, BQ678339, BU172010, BU167922, BU163559, BQ679317, BQ679254, BQ679251
Pif1: AI655645.1, AI280491.1, AI654749.1, AI333976.1, AA743647.1, AA872541.1, AA279102.1, AA278838.1, AI827264.1, AI652391.1, AW004048.1, CN358868.1, CN358870.1, T85126.1, T88870.1, CN358869.1, T54683.1, T54599.1, CN358871.1, CN265097.1, AA464521.1, BG231673.1, AA642924.1, BX109827.1, AI696210.1, AI745642.1, AI984536.1, AW170361.1, AW590310.1, AW663962.1, AW801494.1, BF516453.1, BG951026.1, BI116535.1, BM043514.1, W60651.1, W60880.1, BM888249.1, BQ061682.1, BQ065272.1, BQ958807.1, BU502486.1, CA310274.1, AA464522.1, BE280562.1, BF316643.1, AA827755.1, CN259034.1, CN277199.1, AA973831.1, CN259037.1, CN259036.1, BX283578.1, AI889087.1, BG323851.1, BI063248.1, BI063942.1, BQ315498.1, BE148134.1
Mms4: BI918962.1, BE613887.1, AW672839.1, R86709.1, R85191.1, H80469.1, CN290252.1, CN281043.1, CN342824.1, R83093.1, BX333338.2, BX327691.2, D25658.1, AW955836.1, BE378681.1, BE542457.1, CN484982.1, R87430.1, BE887145.1, BE895828.1, BE897152.1, AU118079.1, BF244395.1, BE547467.1, BG028794.1, BG000465.1, BG167025.1, BG167838.1, BG255030.1, BG256327.1, BG436043.1, BG393362.1, BG498016.1, BI084419.1, BI088431.1, BF793987.1, BG996952.1, BI255051.1, BI256195.1, BI258650.1, BM462968.1, BM800592.1, BM802118.1, BM809503.1, BM906256.1, BM918347.1, BQ072173.1, BG992888.1, BQ216341.1, BQ218372.1, BQ230208.1, BQ232225.1, BG116791.1, BG120099.1, AA243757.1, AA443229.1, AA481119.1, AA774064.1, BX108233.1, BX333337.2, BX443561.2, BX328975.1, AI305107.1, BP429202.1, BX509606.1, BP430970.1, AW250729.1, BP430731.1, CK023740.1, CN482590.1, BQ082456.1
TopoisomeraseIIIa: BM462184.1, BQ226006.1, BQ215187.1, AI933546.1, AI694682.1, AW005757.1, AI871758.1, AI627306.1, AI357363.1, CN431712.1, CN431714.1, AI131044.1, CN431713.1, CN431717.1, CN431715.1, AI863107.1, N21546.1, AI652693.1, AI637907.1, AI917456.1, AW370762.1, AW375839.1, AW411282.1, AW411283.1, AW449041.1, AW449710.1, AW450373.1, CK300631.1, CD619024.1, CD619023.1, AW513442.1, AW748535.1, AW954652.1, BE062796.1, BE062799.1, BE062870.1, BE062878.1, BE275290.1, BE294390.1, BE297536.1, BE383990.1, BE384385.1, BE388003.1, BE389807.1, BE408865.1, BE410098.1, BE886538.1, AU125151.1, AU130137.1, BF307775.1, BF345890.1, AW601235.1, BF060985.1, AU148874.1, AU152155.1, BF772443.1, BF913078.1, AL555800.3, AL578214.3, BG281391.1, BG333658.1, BM046431.1, BM046548.1, BM049492.1, BM553540.1, BM683614.1, BM804018.1, BM817686.1, BM910465.1, BQ187307.1, BQ334676.1, BQ342906.1, BQ673046.1, BM929666.1, BQ883495.1, BQ897944.1, BQ929795.1, BU159208.1, AL601602.1, BU542042.1, BU191611.1, BU902730.1, AA307047.1, AA325934.1, AI206124.1, AI206134.1, CB123137.1, R45840.1, AL040785.1, BX394136.2, BX359327.2, BX359328.2, BX348607.2, AI969044.1, AI978571.1, BX499775.1, AW270386.1, AW351792.1, AW370749.1, AW370750.1, AW370754.1, AW370756.1, AW370757.1, AW370758.1, BU169620.1
Mus81: BI828324.1, BI822910.1, BI772783.1, BI766615.1, BI551731.1, BE313033.1, BF317447.1, BG912942.1, BG388554.1, BG336401.1, BM926996.1, BG334598.1, BG330488.1, BG328798.1, BG327203.1, BG165822.1, BM561952.1, BM795493.1, BI871701.1, BI909656.1, W05036.1, BM787599.1, BM015068.1, BM762869.1, BM715429.1, W46505.1, BM051590.1, BM193717.1, BM820646.1, BM673914.1, W46441.1, W46397.1, W46466.1, D81040.1, D81583.1, N66260.1, BI083900.1, BI084569.1, BI058696.1, N74665.1, BI015411.1, BI225125.1, BI261175.1, BI334628.1, BI520226.1, BI520852.1, BI495735.1, BI495736.1, N99229.1, BI818186.1, BI818415.1, BI821127.1, BI816797.1, AA278513.1, CA426286.1, CA428478.1, CA439511.1, CA488369.1, AA310067.1, AA321039.1, AA325265.1, AA353351.1, AA361208.1, AA361844.1, AA410784.1, AA412362.1, AA425903.1, AA483867.1, T24587.1, AA588568.1, AA742229.1, AA742315.1, R07365.1, AA767217.1, AA808486.1, AA811878.1, AA830456.1, AA831614.1, AA935774.1, BM828633.1, W86124.1, BQ004754.1, BQ007168.1, W94929.1, W92200.1, W96213.1, W96307.1, BQ219750.1, BQ421044.1, BQ673374.1, BQ716313.1, BM147893.1, BQ951454.1, BQ787518.1, BU626130.1, BU630449.1, AA195097.1, AA195293.1, AA235399.1, BU855063.1, AA256727.1, AA258031.1, AA261839.1, AA262485.1, AA262698.1, CB989437.1, CB995814.1, BX329339.2, BX363788.2, BX363789.2, BX364239.2, BX364240.2, BX376440.2, BX376441.2, BX352736.2, BX352737.2, BX400774.2, BX393197.2, AW008546.1, Z46145.1, Z41778.1, AW080590.1, AW081005.1, CF130974.1, AW057824.1, AI174987.1, CF272441.1, AW292451.1, AW296475.1, AA989261.1, AI004770.1, AI027750.1, AI078127.1, AI161039.1, BX117949.1, AI223161.1, AI198223.1, AI289132.1, AI291347.1, AI312012.1, AI423724.1, AI355186.1, AI444946.1, AI565701.1, AI568723.1, AI401565.1, AI589837.1, AI561084.1, AI696162.1, AI701699.1, AI708157.1, AI796616.1, AI809463.1, BE843407.1, AV683439.1, AV684455.1, AV692941.1, AV695347.1, BE871764.1, AV706138.1, AV737334.1, AV749817.1, D53819.1, BF337818.1, BF340725.1, BF345411.1, AA836608.1, H70568.1, BF594105.1, BF594519.1, BF742954.1, BF801584.1, BG026984.1, BF940759.1, AL535449.3, AL535450.3, BG393857.1, AW387757.1, CF995326.1, AW469599.1, CD632462.1, CD632461.1, AW905089.1, AW954207.1, CN336481.1, CN336479.1, CN336477.1, CN336478.1, CN336480.1, AW967947.1, CN422010.1, CN422011.1, CN422012.1, AW978460.1, CV028339.1, BE328203.1, H25803.1, BE379473.1, BE396264.1, BE396772.1, BE513701.1, BE564111.1, AW365100.1, AW365101.1
SIRT1(Sirtuin): AI037953.1, AA236993.1, N23557.1, H98832.1, R86123.1, AA044634.1, AI381553.1, AA608812.1, AI378978.1, AI367389.1, CN357085.1, AI972705.1, H12698.1, AI217748.1, CN357086.1, BE072031.1, BE081871.1, BE245026.1, BE463430.1, AV660110.1, AV660133.1, D59300.1, BE883278.1, D62968.1, AV704288.1, AV704956.1, AV750129.1, BF445130.1, BF692058.1, BF848464.1, BF848494.1, AW615289.1, AV718812.1, AV720195.1, BF590111.1, BF796692.1, BG026102.1, BG036612.1, BF999696.1, BG178600.1, BG282746.1, BG283059.1, BG496097.1, BG498089.1, N68314.1, BI091351.1, BG705339.1, BG717615.1, BI258271.1, AL599794.1, BI520244.1, BI869083.1, BI918557.1, BM273130.1, BM475115.1, BM697223.1, BM905888.1, BM980158.1, BM986798.1, BQ025488.1, BQ219206.1, BQ226337.1, BQ631955.1, BQ632248.1, BM152225.1, BU186744.1, BM452557.1, AA251252.1, AA382573.1, AA452304.1, AA460952.1, AA461259.1, AA828109.1, BX105044.1, AI751813.1, AI751814.1, AI807525.1, AL042303.1, CD110682.1, AW007728.1, AW020605.2, AW021852.1, BX505161.1, AW504399.1, CK820052.1, CK820053.1, AW967429.1, AW996552.1, BU935054.1
Esp1:BM456594.1, BM051112.1, BM049903.1, BM044277.1, BM013405.1, BI262337.1, BI117483.1, BI200147.1, BI195989.1, BI023133.1, BG821987.1, BG767950.1, BG760762.1, BG756617.1, BG684814.1, BG493667.1, BG490228.1, BG480927.1, BG479609.1, BG469946.1, BG386315.1, BG337498.1, BG328178.1, BF932278.1, BF973206.1, BF972380.1, BF764335.1, BF742768.1, AA780037.1, AA581005.1, AA580948.1, AA548572.1, T86767.1, AA455415.1, T86675.1, AA339975.1, AA248889.1, BU856483.1, BU855930.1, BU844826.1, BQ958098.1, BQ939849.1, BQ894059.1, BQ893225.1, BQ882493.1, BQ881349.1, BF924624.1, BQ361233.1, BQ069829.1, BQ052875.1, BQ052507.1, BQ014621.1, BM905149.1, BM837056.1, BM797577.1, BM468940.1, AW207246.1, CF137736.1, CF137709.1, CF137594.1, CF135495.1, BX483646.1, CD579284.2, AW009863.1, AW008862.1, CD359905.1, CD299902.1, BX415621.2, AI816969.1, AL046060.1, AI800823.1, R42883.1, AI458447.1, AI446360.1, AI283098.1, AI268609.1, AI214569.1, AI127437.1, R21501.1, AA928961.1, AI023991.1, AI023899.1, AI022797.1, AA948058.1, BF512245.1, BF698487.1, BF697145.1, BF686746.1, BF683733.1, AA694341.1, BF314077.1, BF155328.1, BF154952.1, BF154938.1, BE538398.1, BE467107.1, CR746800.1, BE019694.1, CN356489.1, CN356487.1, CN356486.1, CN356485.1, CN356484.1, CN356488.1, CN356495.1, CN356494.1, CN356493.1, CN356492.1, CN356491.1, CN356490.1, AW867242.1, AW497592.1
MPG: BE567173.1, BF678850.1, BG769688.1, BM663214.1, BM690361.1, BM707428.1, BM750136.1, BM771938.1, BM796074.1, BM796301.1, BM822805.1, BM823382.1, BM823606.1, BM825519.1, BM831379.1, W69334.1, W69335.1, BM852297.1, BM909194.1, BM914408.1, W76127.1, BM922561.1, BM970297.1, BQ053339.1, BQ224541.1, AA010929.1, AA011317.1, BQ416588.1, BQ416589.1, BQ416891.1, BQ416892.1, BQ430971.1, BF174738.1, BG469815.1, BG479289.1, BG574541.1, BG686214.1, BG779735.1, BG746848.1, BG763639.1, BG823448.1, BG830627.1, BI253826.1, BI259059.1, BI524092.1, N90880.1, N91934.1, BI552950.1, BI713520.1, BI759543.1, BI818264.1, BI820665.1, BI791744.1, BI870400.1, BI858760.1, BI964886.1, BI906325.1, W17097.1, BM194361.1, BM471029.1, BM543869.1, BM552363.1, BM556912.1, BU565588.1, BU631253.1, AA187311.1, AA187412.1, BU684880.1, BU687924.1, BU858254.1, BU860310.1, BU956115.1, CA337274.1, CA423548.1, CA438664.1, CA441991.1, CA488184.1, CA488371.1, AA299077.1, AA285256.1, AA491244.1, AA503832.1, AA527886.1, AA568795.1, AA578450.1, AA603076.1, AA621361.1, AA732078.1, AA761676.1, AA767201.1, AA768478.1, AA768552.1, AA806008.1, AA853981.1, AA857130.1, AA026824.1, AA026957.1, BQ447759.1, BQ668747.1, BQ675987.1, BQ676108.1, BQ676179.1, BQ676405.1, BQ678708.1, BQ678722.1, BQ680099.1, BQ682489.1, BQ684616.1, BQ686780.1, BQ773643.1, BM147473.1, BM149314.1, BQ888825.1, BQ921148.1, BQ927180.1, BQ945550.1, AA065084.1, AA064997.1, BU195384.1, BU149567.1, BU157028.1, BU168113.1, BU172290.1, AA113980.1, AA113972.1, AA115941.1, AA122238.1, AI695611.1, AI739369.1, AI750356.1, AI754347.1, AI765874.1, AI798386.1, CB267218.1, BX281276.1, AI817691.1, AI913581.1, AI922106.1, AI928586.1, CB997674.1, BX395164.2, CD105357.1, BX353976.2, BX372753.2, BX392614.1, BX357530.2, BX391673.2, AI961117.1, CD368856.1, AW007326.1, AW072347.1, AW083039.1, AW131829.1, AW149104.1, AJ573841.1, AJ573842.1, AW204546.1, AW206735.1, AA971357.1, AI015443.1, AI037999.1, AI089498.1, AI131317.1, AI143697.1, CB044049.1, CB044050.1, CB048492.1, CB048493.1, CB048779.1, CB049248.1, CB049249.1, AI149080.1, AI188471.1, AI205596.1, AI208926.1, AI209171.1, CB128954.1, AI203215.1, AI345964.1, AI350908.1, AI382391.1, AI453105.1, AI457314.1, AI521404.1, AI553664.1, AI569449.1, AI580320.1, AI679185.1, AI695608.1, BF001487.1, BF002356.1, T28409.1, BF109116.1, BF219424.1, AA862053.1, BF664362.1, BF669361.1, BF526924.1, BF572325.1, BF790595.1, BG033001.1, BG033146.1, BF974328.1, BF940863.1, BG165742.1, BG153198.1, AL520051.3, AL520052.3, AL521514.3, AL521515.3, N26769.1, AL524386.3, AL524387.3, AL527543.3, AL527544.3, AL530961.3, AL530962.3, N30855.1, BG284431.1, BG430698.1, F04542.1, AW291955.1, CF993786.1, AW452798.1, AW590115.1, AW593038.1, CK902061.1, CN266626.1, CN266627.1, CN266628.1, CN266629.1, CN266630.1, CN266631.1, CN266632.1, AW973756.1, BE045501.1, BE207420.1, BE275484.1, BE385924.1, BE394756.1, BE408565.1, BE465105.1, BE502294.1, BE538276.1, BE733520.1, BE735753.1, BE780181.1, AV694099.1, BE908188.1, BE909470.1, BF000140.1, BF000556.1, CB114652.1, CN276703.1, N41382.1, BQ694950.1
Poll: BQ052050.1, BQ072779.1, BQ232853.1, BG823706.1, BE264721.1, BI758654.1, BE539840.1, BE541711.1, BG389885.1, BG331116.1, BI770175.1, BE880092.1, BM544877.1, BI825514.1, BE974036.1, BI827122.1, BI910222.1, BI906881.1, BI909106.1, BI906886.1, BI772047.1, BG945087.1, BI091406.1, BG770791.1, BG764790.1, BG763955.1, BG751184.1, BG749688.1, BG490202.1, BF171635.1, AL562678.3, AL541662.3, AL526446.3, BG149290.1, BG024414.1, BF807384.1, BF591938.1, BF476040.1, BF475279.1, AA807380.1, AA742404.1, T81701.1, CA406519.1, CA405484.1, BU855318.1, AA234405.1, BU618135.1, BU194042.1, BU184350.1, BU191914.1, BU159682.1, BQ957310.1, BQ932866.1, BM148925.1, M145476.1, BG118565.1, BG056482.1, BQ311579.1, BQ276405.1, AL702021.1, AL702011.1, AL698041.1, M923533.1, BM908370.1, W69888.1, BM824844.1, BM801377.1, BM354225.1, BM273229.1, BI912822.1, BI909369.1, AW406239.1, AW418802.1, AW377370.1, AW377335.1, AW377300.1, AW377298.1, AW377264.1, AW377257.1, AW367852.1, CF147037.1, CF140209.1, CF140207.1, BX426881.2, BX372137.1, BX384565.2, BX384564.2, AA991853.1, AA927738.1, AA922738.1, CA976110.1, CB151800.1, CB131141.1, AI538103.1, AI922500.1, BX333693.2, BX351220.1, BX361517.2, BX382774.2, BX398077.2, BX398078.2, BX400678.2, BX374468.2, BX390819.1, BE144586.1, BE162920.1, BP871239.1, CV025896.1, BE392666.1, BE562674.1, BE744935.1, BE819364.1, BE905104.1, BE938379.1, BE938389.1, AV705731.1, AU118033.1, AU122737.1, AU141478.1, AU144697.1, BF433511.1, AW673654.1, AW731648.1, AW752914.1, AW752922.1, AW768836.1, AW769721.1, CK820138.1, CK820139.1, CN304569.1, CN304570.1, CN304571.1, CN304572.1, CN304573.1, CN304574.1, CN304575.1, CN304576.1, H11886.1, CD243848.1, BX448084.2, BG488800.1, BI027900.1, BI460283.1, BM479907.1, BM541632.1, BM563437.1, BQ232479.1, BQ923975.1, BQ954336.1, BU195355.1
Polm: BI914097.1, BI908863.1, BI907196.1, BI858799.1, BG700584.1, BM920340.1, BI769194.1, BG483069.1, BG499408.1, BG910514.1, BI029339.1, BI001584.1, BI752559.1, BI838830.1, BI857029.1, BM739081.1, BM739884.1, BM739966.1, BM744174.1, AV692664.1, AV697631.1, AV697781.1, AV699741.1, BF102699.1, AU129189.1, AA694217.1, AA766124.1, AW613566.1, BF530871.1, BF819685.1, BF895261.1, BG253328.1, AL523598.3, AL529987.2, AL529988.3, AL562232.3, BG231904.1, BG386713.1, BM148157.1, BM148944.1, BM149019.1, BM151641.1, BU517199.1, BU520948.1, AA077726.1, CA388951.1, CA487306.1, CA487434.1, AA298793.1, CA944555.1, AA507121.1, AA605050.1, AA769270.1, AA814924.1, AA815032.1, AA832314.1, AA917987.1, BM744180.1, BM747399.1, BM752457.1, BM755685.1, BM756419.1, BM756478.1, BM804478.1, BM808078.1, BM853841.1, BM911482.1, BM911832.1, AL700896.1, BQ015336.1, BQ214851.1, BQ686436.1, AA046576.1, AA046663.1, BG116876.1, BM147833.1, BX390956.2, BX350666.1, BX385063.2, BX385064.2, CD109226.1, BX354131.1, BX354132.2, BX351215.2, BX376517.2, BX376518.2, BX395027.2, BX335337.2, BX335338.2, BX383403.1, BX383404.2, BX383221.2, BX402828.2, BX402829.2, BX384388.2, AI025113.1, AA928729.1, AI057140.1, AI208523.1, AA910584.1, AI365238.1, AI365240.1, AI392687.1, AI419960.1, AI458707.1, AI459543.1, AI469103.1, AI627311.1, AI652512.1, AI654109.1, AI738949.1, AI767982.1, AI638032.1, CB990757.1, BE241524.1, BE241656.1, BE241950.1, BE242681.1, BE242829.1, BE242932.1, BE243489.1, BE244287.1, BE247085.1, BE247483.1, CR735361.1, BE503442.1, BE789823.1, AV685517.1, AV688018.1, AV688777.1, AV689313.1, AV689923.1, AV691130.1, BX393262.2, BX435165.2, BX419627.2, CD252488.1, BX477278.1, AW070683.1, AW137352.1, AW182301.1, CF529830.1, AW207742.1, AW296010.1, AW361738.1, AW402473.1, AW575118.1, AW578625.1, AW592532.1, CN480773.1, CN304577.1, CN304578.1, CB104684.1, AI438940.1, CB266611.1, CN293022.1, AA078383.1
EndoV: BQ279208.1, BM554738.1, BM911430.1, BI830073.1, BI829389.1, BG681481.1, BG819544.1, BI117355.1, BI551407.1, BQ287914.1, BQ050806.1, BQ024655.1, BQ021027.1, W87446.1, BM926784.1, BM128679.1, BM128571.1, BM128352.1, AA720808.1, AA452047.1, AA363057.1, AA351281.1, BU621053.1, BU553848.1, BU527982.1, BQ957094.1, AA056490.1, BQ923151.1, BQ923003.1, BQ772531.1, BQ435901.1, BQ429806.1, BQ429804.1, BQ427432.1, BQ417371.1, BQ342726.1, R14533.1, CB143295.1, AI370900.1, BX334744.2, BX355957.2, Z41683.1, AW157406.1, CK819308.1, CN288502.1, CN310874.1, CN310875.1, CN310876.1, AW975617.1, H09974.1, BE619534.1, BE905153.1, BE938460.1, BF686490.1, BF477753.1, AL541721.3, AL569045.3, BG749082.1, BI549266.1, BI550542.1, BI550562.1, BI837982.1, BI917934.1, BM007984.1, BM008131.1, BM043073.1, BM047737.1, BX092874.1, AI219827.1, AI249283.1, AA926664.1, AI223657.1, AI290823.1, AI300416.1, AI311040.1, AI349370.1, AI393803.1, AI307620.1, AI571214.1, AI635870.1, AI660440.1, AI681370.1, AI702794.1, AW001931.1, AW136860.1, AW204051.1, AW438764.1, BE041666.1, BE043347.1, BE049112.1, BE219425.1, BE219749.1, BE672512.1, BF194919.1, BF196166.1, BF718311.1, BF840896.1, BM662670.1, BM665527.1, BM671155.1, BM684408.1, BM689003.1, BM710007.1, BM711618.1, BM930887.1, AA451847.1, AA593804.1, AA617805.1, T96971.1
KNTC2(NDC80): BG612856.1, BG532554.1, BG531886.1, BI093871.1, BG500282.1, BI825656.1, BE561023.1, BE564344.1, BE565202.1, BE566742.1, BE903220.1, BQ233581.1, BQ425406.1, BF029347.1, CD557751.1, BU507911.1, BF977553.1, BF976962.1, BF700934.1, BF219086.1, BF244797.1, BF700668.1, BF246890.1, BF684028.1, BF667950.1, BF666100.1, BF665251.1, AU151690.2, BF540908.1, AU099103.1, BF576929.1, BG403284.1, BF589484.1, AL583281.3, AL583241.3, AL531915.3, AL531914.3, AL527360.3, BF984727.1, AL527307.3, BG257162.1, BF899120.1, BF994346.1, BF978548.1, BU633554.1, AA188980.1, AA188981.1, AA189047.1, AA211359.1, BU943322.1, AA249583.1, AA249666.1, CA311030.1, CA446863.1, AA312280.1, T89463.1, AA492580.1, AA628019.1, AA639709.1, AA700427.1, AA857356.1, AA878068.1, BG679506.1, BI087094.1, BI260526.1, N88235.1, BI861865.1, BM194061.1, BM453009.1, BM476696.1, BM806248.1, BM828736.1, BM995677.1, W72679.1, AL711170.1, AL710845.1, BQ307283.1, BQ307306.1, BQ776047.1, BQ776118.1, CN294243.1, CN294241.1, CN294240.1, CN294239.1, CN294238.1, CN294237.1, AW821289.1, AW955129.1, AW573107.1, AW449014.1, BP430527.1, AW069561.1, AI979323.1, BX453617.2, AI955047.1, AI954614.1, BX431751.2, BX372554.2, BX353230.2, BX351284.2, BX333981.2, AI913466.1, AI866885.1, BX284007.1, BF246242.1, AI660156.1, AI380253.1, BP369219.1, BF218992.1, BP282259.1, AU129601.1, BP283529.1, AI341287.1, BF084870.1, BP290528.1, BP242960.1, BP239153.1, CV030676.1, CN294245.1, CN294236.1, BF082771.1, BE503512.1, AI341285.1, BF038467.1, BE543964.1, CB150849.1, CB160181.1, BF001266.1, BE672102.1, CN294234.1, CN294233.1, R94766.1, CV363738.1, BE927464.1, AA911686.1, AV718407.2, BE940500.1, BE857720.1, BE889796.1, AV718036.1, BF687621.1, BF447144.1, CN294232.1, CN294235.1, CN294244.1, R92253.1
본 발명의 바람직한 태양에 있어서는, 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자) 또는 상기 각 EST에 대응하는 mRNA에서의 연속하는 RNA 영역을 한쪽의 쇄로 하는 RNAi 효과를 갖는 이중쇄 RNA를 포함하는 아포토시스 유도제를 제공한다.
상술한 바와 같이 상기 어느 하나에 기재된 유전자에는, 동일한 유전자이어도 여러 가지의 다형이 포함되어 있는 경우가 있다. 당업자에 있어서는, 배열번호: 1~637, 810~908의 어느 하나에 기재된 염기배열 또는 상기 EST 배열에 대해, 예를 들어 상기 어느 하나에 기재된 유전자에 관한 공공의 다형 데이터베이스로부터의 정보를 가미하고, RNAi 효과를 갖는 것이 기대되는 RNA의 배열을 적절히 설계할 수 있다. 이러한 RNA를 포함하는 아포토시스 유도제도 본 발명에 포함된다. 또한, 당업자에 있어서는, 복수종 제작된 본 발명의 이중쇄 RNA로부터 최적의 RNAi 효과를 갖는 RNA를 적절히 선택하여 아포토시스 유도제로 하는 것도 가능하다.
본 발명의 상기 「RNAi 효과를 갖는 이중쇄 RNA」의 구체예로서, 도 1~도 4 및 도 28~도 32에 기재된 염기배열(배열번호: 724~809, 974~1063의 어느 하나에 기재된 염기배열)을 당해 이중쇄 RNA의 한쪽의 쇄로 하는 siRNA 분자(배열번호: 724~809, 974~1063의 어느 하나에 기재된 염기배열과 그 상보 쇄로 이루어지는 siRNA 분자)를 들 수 있다. 즉, 본 발명의 하나의 태양으로서는, RNAi 효과를 갖는 이중쇄 RNA의 한쪽의 쇄가 배열번호: 724~809, 974~1063의 어느 하나에 기재된 염기배열로 이루어지는 siRNA 분자(배열번호: 724~809, 974~1063의 어느 하나에 기재된 염기배열과 그 상보 쇄로 이루어지는 siRNA 분자)를 유효성분으로서 포함하는 암세포 특이적 아포토시스 유도제를 제공한다.
또한, 상기 siRNA 분자에 있어서 이중쇄를 형성하는 영역의 한쪽의 RNA 배열은, 반드시 상기 배열번호: 724~809, 974~1063의 어느 하나에 기재된 염기배열과 완전히 동일한 것에 제한되지 않는다. 예를 들어, 당해 염기배열에 있어서 1 또는 복수의 염기가 개변된 배열로 이루어지는 염기배열을 이중쇄 RNA의 한쪽의 쇄로 하는 siRNA 분자이어도, 본 발명의 유전자의 발현을 억제하는 기능을 갖는 것이면 된다.
즉, 본 발명의 바람직한 태양에 있어서, RNAi 효과를 갖는 이중쇄 RNA란, 당해 이중쇄의 한쪽의 쇄가 배열번호: 724~809 또는 974~1063의 어느 하나에 기재된 염기배열에 있어서 1 또는 복수의 염기가 부가, 결실, 치환된 염기배열이고, 다른 쪽의 쇄가 당해 염기배열과 상보적인 염기배열인 것을 특징으로 하는 이중쇄 RNA로서, 본 발명의 유전자의 발현을 억제하는 기능을 갖는 이중쇄 RNA이다. 또, 상기 「복수」란, 통상 소수를 의미하고, 보다 구체적으로는 2~10을 의미하며, 바람직하게는 2~5를 의미하고, 보다 바람직하게는 2~3을 의미한다.
또한, 본 발명의 바람직한 태양으로서는, 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)의 발현을 억제하는 화합물이 이하의 (a) 또는 (b)인 아포토시스 유도제를 제공한다.
(a) 본 발명의 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)의 전사 산물 또는 그 일부에 대한 안티센스 핵산
(b) 본 발명의 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)의 전사 산물을 특이적으로 개열하는 리보자임 활성을 갖는 핵산
본 발명에서의 「핵산」이란, RNA 또는 DNA를 의미한다. 특정의 내재성 유전자의 발현을 저해(억제)하는 방법으로서는, 안티센스 기술을 이용하는 방법이 당업자에게 잘 알려져 있다. 안티센스 핵산이 표적 유전자의 발현을 저해하는 작용으로서는, 이하와 같은 복수의 요인이 존재한다. 즉, 삼중쇄 형성에 의한 전사 개시 저해, RNA 폴리머라아제에 의해 국부적으로 개상태 루프 구조가 만들어진 부위와의 하이브리드 형성에 의한 전사 저해, 합성이 계속 진행되고 있는 RNA와의 하이브리드 형성에 의한 전사 저해, 인트론과 엑손의 접합점에서의 하이브리드 형성에 의한 스플라이싱 저해, 스플라이솜 형성부위와의 하이브리드 형성에 의한 스플라이싱 저해, mRNA와의 하이브리드 형성에 의한 핵에서 세포질로의 이행 저해, 캡핑부위나 폴리(A) 부가 부위와의 하이브리드 형성에 의한 스플라이싱 저해, 번역개시인자 결합부위와의 하이브리드 형성에 의한 번역개시 저해, 개시 코돈 근방의 리보솜 결합부위와의 하이브리드 형성에 의한 번역 저해, mRNA의 번역 영역이나 폴리솜 결합부위와의 하이브리드 형성에 의한 펩티드 쇄의 신장 저해 및 발현제어영역과 전사조절인자의 상호작용 부위와의 하이브리드 형성에 의한 유전자 발현 저해 등이다. 이와 같이 안티센스 핵산은, 전사, 스플라이싱 또는 번역 등 여러 가지의 과정을 저해함으로써, 표적 유전자의 발현을 저해한다(히라시마 및 이노우에 저, 신생화학실험강좌 2핵산 IV유전자의 복제와 발현, 일본 생화학회편, 동경화학동인, 1993년, p.319-347).
본 발명에서 사용되는 안티센스 핵산은, 상기 어떠한 작용에 의해 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)의 발현을 저해해도 된다. 하나의 태양으로서는, 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)의 mRNA의 5'단 근방의 비번역 영역에 상보적인 안티센스 배열을 설계하면, 유전자의 번역 저해에 효과적이라고 생각된다. 또한, 코드 영역 또는 3'측의 비번역 영역에 상보적인 배열도 사용할 수 있다. 이와 같이, 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)의 번역영역뿐만 아니라, 비번역 영역의 배열의 안티센스 배열을 포함하는 핵산도, 본 발명에서 이용되는 안티센스 핵산에 포함된다. 사용되는 안티센스 핵산은, 적당한 프로모터의 하류에 연결되고, 바람직하게는 3'측에 전사 종결 시그널을 포함하는 배열이 연결된다. 또한, 임상 응용을 고려하는 경우, 사용되는 안티센스 핵산은, 통상 합성 올리고머이고, 뉴클레아제 분해에 대한 감수성을 줄이며, 또한 안티센스 핵산으로서의 활성을 유지하기 위해, 인산 에스테르 결합부의 O(산소)를 S(유황)로 치환한 S올리고(포스포로티오에이트형 올리고 뉴클레오티드)의 이용이 일반적으로 알려져 있다. 이 S올리고는 현재에서는 안티센스 약으로서, 직접 환부에 주입되는 임상시험이 행해지고 있다. 본 발명에 있어서도 이 S올리고를 매우 적합하게 사용할 수 있다. 안티센스 핵산의 배열은, 표적 유전자 또는 그 일부와 상보적인 배열인 것이 바람직하지만, 유전자의 발현을 유효하게 억제할 수 있는 한 완전히 상보적이 아니어도 된다. 전사된 RNA는, 표적 유전자의 전사 산물에 대해 바람직하게는 90% 이상, 가장 바람직하게는 95% 이상의 상보성을 갖는다. 안티센스 핵산을 이용하여 표적 유전자의 발현을 효과적으로 억제하는 데는, 안티센스 핵산의 길이는 적어도 15 염기 이상이고, 바람직하게는 100 염기 이상이며, 더 바람직하게는 500 염기 이상이다.
또한, 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)의 발현의 저해는, 리보자임 또는 리보자임을 코드하는 DNA를 이용하여 행하는 것도 가능하다. 리보자임이란, 촉매활성을 갖는 RNA분자를 가리킨다. 리보자임에는 여러 가지의 활성을 갖는 것이 존재하고, RNA를 부위 특이적으로 절단하는 리보자임의 설계도 가능하다. 리보자임에는, 그룹I 인트론형이나 RNase P에 포함되는 M1 RNA와 같이 400 뉴클레오티드 이상의 크기의 것도 있지만, 해머 헤드형이나 헤어핀형이라고 불리는 40 뉴클레오티드 정도의 활성 도메인을 갖는 것도 있다(고이즈미 마코토 및 오오츠카 에이코, 단백질 핵산 효소, 1990년, 35, 2191).
예를 들어, 해머 헤드형 리보자임의 자기절단 도메인은, G13U14C15라는 배열의 C15의 3'측을 절단하는데, 그 활성에는 U14와 A9의 염기쌍 형성이 중요하게 되고, C15 대신에 A15 또는 U15에서도 절단될 수 있는 것이 나타나 있다(Koizumi, M.등 저, FEBS Lett, 1988년, 228, 228.). 기질 결합부위가 표적부위 근방의 RNA 배열과 상보적인 리보자임을 설계하면, 표적 RNA 중의 UC, UU 또는 UA라는 배열을 인식하는 제한 효소적인 RNA 절단 리보자임을 작출할 수 있다(Koizumi, M. 등 저, FEBS Lett, 1988년, 239, 285., 고이즈미 마코토 및 오오츠카 에이코, 단백질 핵산 효소, 1990년, 35, 2191., Koizumi, M. 등 저, Nucl Acids Res, 1989년, 17, 7059.).
또한, 헤어핀형 리보자임도 본 발명의 목적에 유용하다. 이 리보자임은, 예를 들어 담배 링 스폿 바이러스의 새틀라이트 RNA의 마이너스 쇄에 발견된다(Buzayan, JM., Nature, 1986년, 323, 349.). 헤어핀형 리보자임으로부터도, 표적 특이적인 RNA 절단 리보자임을 작출할 수 있는 것이 나타나 있다(Kikuchi, Y. & Sasaki, N., Nucl Acids Res, 1991, 19, 6751., 기쿠치 히로시, 화학과 생물, 1992, 30, 112.). 이와 같이, 리보자임을 이용하여 본 발명에서의 염색체 안정화 관련 유전자의 전사 산물을 특이적으로 절단함으로써, 당해 유전자의 발현을 저해할 수 있다.
또, 본 발명은, 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)에 의해 코드되는 단백질의 기능(활성)을 억제하는 화합물을 유효성분으로서 함유하는 암세포 특이적 아포토시스 유도제에 관한 것이다.
본 발명의 염색체 안정화 관련 유전자에 의해 코드되는 단백질에는, 당해 단백질의 아미노산 배열에 있어서 1 또는 복수의 아미노산이 결실, 치환 또는 부가된 아미노산 배열을 포함하는, 염색체 안정화 관련 유전자에 의해 코드되는 단백질의 변이 단백질 또는 동족체 단백질로서, 염색체 안정화 관련 유전자에 의해 코드되는 단백질과 기능적으로 동등한 단백질도 포함된다. 여기서, 「기능적으로 동등한 단백질」이란, 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)에 의해 코드되는 단백질에서의 기능(예를 들어, 상술한 (a)~(s)의 어느 하나의 기능)과 같은 기능을 구비한 단백질이다.
혹은 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)에 의해 코드되는 단백질의 아미노산 배열에 대해, 예를 들어 90% 이상, 바람직하게는 95% 이상, 더 바람직하게는 99% 이상의 상동성을 갖는 단백질을 염색체 안정화 관련 유전자에 의해 코드되는 단백질과 기능적으로 동등한 단백질로서 나타낼 수 있다.
본 발명의 바람직한 태양에 있어서는, 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)에 의해 코드되는 단백질의 기능(활성)을 억제하는 화합물이 이하의 (a)~(c)의 어느 하나에 기재된 화합물인 아포토시스 유도제를 제공한다. 이들의 화합물은, 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)에 의해 코드되는 단백질의 기능 또는 활성을 저해함(저하시킴)으로써, 암세포에 대해 아포토시스 유도작용을 갖는 것이라고 생각된다.
(a) 본 발명의 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)에 의해 코드되는 단백질에 대해 우성 음성의 성질을 갖는 변이체 단백질
(b) 본 발명의 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)에 의해 코드되는 단백질에 결합하는 항체
(c) 본 발명의 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)에 의해 코드되는 단백질에 결합하는 저분자 화합물
상기 (a)에 있어서 「우성 음성의 성질을 갖는 변이체 단백질」이란, 내재성의 야생형 단백질의 활성을 소실 또는 저하시키는 기능을 갖는, 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)에 의해 코드되는 단백질 변이체를 가리킨다.
또한, 상기 (b)의 「항체」는, 당업자에게 주지의 방법에 의해 조제하는 것이 가능하다. 폴리클로날 항체이면, 예를 들어 다음과 같이 하여 얻을 수 있다. 천연 또는 재조합의 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)에 의해 코드되는 단백질, 혹은 GST와의 융합 단백질로서 대장균 등의 미생물에 있어서 발현시킨 재조합체인 염색체 안정화 관련 유전자에 의해 코드되는 단백질, 또는 그 부분 펩티드를 토끼 등의 소동물에 면역하여 혈청을 얻는다. 이를, 예를 들어 황산 암모늄 침전, 프로틴A 칼럼 및 프로틴G 칼럼, DEAE 이온교환 크로마토그래피, 염색체 안정화 관련 유전자에 의해 코드되는 단백질이나 합성 펩티드를 커플링한 친화성 칼럼 등에 의해 정제함으로써 조제한다. 또한, 모노클로날 항체이면, 예를 들어 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)에 의해 코드되는 단백질 또는 그 부분 펩티드를 마우스 등의 소동물에 면역을 행하고, 상기 마우스로부터 비장을 적출하며, 이를 잘게 부수어 세포를 분리하고, 당해 세포와 마우스 미에로마 세포를 폴리에틸렌 글리콜 등의 시약을 이용하여 융합시키며, 이에 의해 생긴 융합세포(하이브리도마) 중에서, 염색체 안정화 관련 유전자에 의해 코드되는 단백질에 결합하는 항체를 생산하는 클론을 선택한다. 다음에, 얻어진 하이브리도마를 마우스 복강 내에 이식하고, 상기 마우스로부터 복수를 회수하며, 얻어진 모노클로날 항체를, 예를 들어 황산 암모늄 침전, 프로틴A 칼럼 및 프로틴G 칼럼, DEAE 이온교환 크로마토그래피, 염색체 안정화 관련 유전자에 의해 코드되는 단백질이나 합성 펩티드를 커플링한 친화성 칼럼 등에 의해 정제함으로써 조제하는 것이 가능하다.
본 발명의 항체는, 본 발명의 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)에 의해 코드되는 단백질에 결합할 수 있는 것이면 특히 제한되지 않고, 상기 폴리클로날 항체, 모노클로날 항체 외에, 인간 항체, 유전자 재조합에 의한 인간화 항체, 또 그 항체 단편이나 항체 수식물 등도 포함된다.
항체 취득의 감작 항원으로서 사용되는 본 발명의 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)에 의해 코드되는 단백질은, 그 유래가 되는 동물 종에 제한되지 않는데, 포유동물, 예를 들어 마우스, 인간 유래의 단백질이 바람직하고, 특히 인간 유래의 단백질이 바람직하다.
본 발명에 있어서, 감작 항원으로서 사용되는 단백질은, 완전한 단백질 외에 당해 단백질의 부분 펩티드이어도 된다. 단백질의 부분 펩티드로서는, 예를 들어 단백질의 아미노기(N) 말단 단편이나 카르복시(C) 말단 단편을 들 수 있다. 본 명세서에서의 「항체」란, 통상 단백질의 전체 길이 또는 단편에 반응하는 항체를 의미한다.
또한, 인간 이외의 동물에 항원을 면역하여 상기 하이브리도마를 얻는 것 외에, 인간 림프구, 예를 들어 EB바이러스에 감염한 인간 림프구를 in vitro로 단백질, 단백질 발현 세포 또는 그 용해물로 감작하고, 감작 림프구를 인간 유래의 영구분열능을 갖는 미에로마 세포, 예를 들어 U266과 융합시켜, 단백질에의 결합활성을 갖는 원하는 인간 항체를 생산하는 하이브리도마를 얻을 수도 있다. 본 발명의 항체를 인체에 투여하는 목적(항체치료)으로 사용하는 경우에는, 면역원성을 저하시키기 때문에, 인간 항체나 인간형 항체가 바람직하다.
염색체 안정화 관련 유전자에 의해 코드되는 단백질과 결합하는 것이 이미 알려져 있는 화합물로서, 예를 들어 상기 어느 하나에 기재된 유전자에 의해 코드되는 단백질에 대한 모노클로날 또는 폴리클로날 항체를 들 수 있다.
본 발명의 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)의 발현 또는 당해 유전자에 의해 코드되는 단백질의 기능(활성)을 억제하는 화합물은, 천연 또는 인공의 화합물의 어느 것이어도 된다. 통상, 당업자에게 주지의 방법을 이용함으로써 제조 또는 취득·단리 가능한 화합물이다. 예를 들어, 유기화합물, 무기화합물, 핵산, 단백질, 펩티드, 당 등의 단일화합물, 혹은, 화합물 라이브러리, 유전자 라이브러리의 발현 산물, 세포추출물, 세포배양 상청, 발효 미생물 생산물, 해양생물 추출물, 식물 추출물 등 또는 당해 추출물로부터 단리 정제되는 화합물을 들 수 있다.
또, 본 발명은, 암세포 특이적 아포토시스 유도제의 스크리닝 방법을 제공한다.
본 발명의 상기 방법의 바람직한 태양에 있어서는, 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)에 의해 코드되는 단백질 또는 그 부분 펩티드와 시험 화합물의 결합활성을 지표로 하는 방법이다. 통상, 염색체 안정화 관련 유전자에 의해 코드되는 단백질 또는 그 부분 펩티드와 결합하는 화합물은, 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)에 의해 코드되는 단백질의 기능을 저해하는 효과를 갖는 것이 기대된다.
본 발명의 상기 방법에 있어서는, 우선, 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)에 의해 코드되는 단백질 또는 그 부분 펩티드와 시험 화합물을 접촉시킨다. 염색체 안정화 관련 유전자에 의해 코드되는 단백질 또는 그 부분 펩티드는, 시험 화합물과의 결합을 검출하기 위한 지표에 따라, 예를 들어 염색체 안정화 관련 유전자에 의해 코드되는 단백질 또는 그 부분 펩티드의 정제된 형태, 세포 내 또는 세포 밖으로 발현한 형태, 혹은 친화성 칼럼에 결합한 형태일 수 있다. 이 방법에 사용하는 시험 화합물은 필요에 따라 적절히 표식하여 사용할 수 있다. 표식으로서는, 예를 들어 방사표식, 형광표식 등을 들 수 있다.
본 방법에 있어서는, 다음에, 염색체 안정화 관련 유전자에 의해 코드되는 단백질 또는 그 부분 펩티드와 시험 화합물의 결합활성을 측정한다. 염색체 안정화 관련 유전자에 의해 코드되는 단백질 또는 그 부분 펩티드와 시험 화합물의 결합활성은, 예를 들어 염색체 안정화 관련 유전자에 의해 코드되는 단백질 또는 그 부분 펩티드에 결합한 시험 화합물에 부가된 표식에 따라 측정할 수 있다. 또한, 세포 내 또는 세포 밖으로 발현하고 있는 염색체 안정화 관련 유전자에 의해 코드되는 단백질 또는 그 부분 펩티드에의 시험 화합물의 결합에 의해 생기는 당해 단백질의 활성의 변화를 지표로서 측정하는 것도 가능하다.
본 방법에 있어서는, 다음에, 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)에 의해 코드되는 단백질 또는 그 부분 펩티드와 결합하는 시험 화합물을 선택한다.
본 방법에 사용하는 시험 화합물로서는, 특히 제한은 없다. 예를 들어, 천연화합물, 유기화합물, 무기화합물, 핵산, 단백질, 펩티드, 당 등의 단일화합물 및 화합물 라이브러리, 유전자 라이브러리의 발현 산물, 세포추출물, 세포배양 상청, 발효미생물 생산물, 해양생물 추출물, 식물 추출물, 인공작출 화합물 등을 들 수 있는데, 이들에 한정되지 않는다.
본 발명의 스크리닝 방법의 다른 태양에 있어서는, 우선 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)를 발현하는 세포 또는 세포추출액과 시험 화합물을 접촉시킨다. 상기 「염색체 안정화 관련 유전자를 발현하는 세포」로서는, 내인성의 염색체 안정화 관련 유전자를 발현하고 있는 세포, 또는 외래성의 염색체 안정화 관련 유전자가 도입되고, 당해 유전자를 발현하고 있는 세포를 이용할 수 있다. 외래성의 염색체 안정화 관련 유전자가 발현한 세포는, 통상 당해 유전자를 포함하는 발현벡터를 숙주세포에 도입함으로써 제작할 수 있다. 이 발현벡터는, 당업자에 있어서는 일반적인 유전자 공학기술에 의해 제작할 수 있다. 본 발명의 스크리닝 방법에 있어서, 염색체 안정화 관련 유전자를 발현하는 세포로서, 예를 들어 MCF7(유방암), A549(폐암), U2OS(골육종), C33A(자궁경암), HT1080(섬유육종), PA-1(난소의 기형암), Tera2(태생기암), T24(방광암), K562(만성 골수성 백혈병), Molt4(급성 림프아구성 백혈병), A172(신경교아세포종), HeLa(자궁경암), HepG2(간암), ACC62(멜라노마), KP4(췌장암), CaKi-1(신장암), MKN45(위암), LNcap(전립선암), MDA-MB435(유방암), EJ 1(방광암), OVCAR3(난소암) 등의 각종 종양세포를 매우 적합하게 사용할 수 있다.
상기 염색체 안정화 관련 유전자를 발현하는 세포에의 시험 화합물의 「접촉」은, 통상 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)를 발현하는 세포의 배양액에 시험 화합물을 첨가함으로써 행하는데, 이 방법에 한정되지 않는다. 시험 화합물이 단백질 등의 경우에는, 당해 단백질을 발현하는 DNA 벡터를 당해 세포에 도입함으로써 「접촉」을 행할 수 있다.
다음에, 본 방법에 있어서는, 염색체 안정화 관련 유전자의 발현수준을 측정한다. 여기서, 「유전자의 발현」에는, 전사 및 번역의 쌍방이 포함된다. 유전자의 발현수준의 측정은, 당업자에게 주지의 방법에 의해 행할 수 있다. 예를 들어, 염색체 안정화 관련 유전자를 발현하는 세포로부터 mRNA를 정법에 따라 추출하고, 이 mRNA를 주형으로 한 노던 하이브리다이제이션법 또는 RT-PCR법을 실시함으로써, 당해 유전자의 전사수준을 측정할 수 있다. 또한, 상기 염색체 안정화 관련 유전자를 발현하는 세포로부터 단백질 화분을 회수하고, 당해 유전자에 의해 코드되는 단백질의 발현을 SDS-PAGE 등의 전기영동법으로 검출함으로써, 유전자의 번역수준을 측정할 수도 있다. 또, 상기 유전자에 의해 코드되는 단백질에 대한 항체를 이용하여 웨스턴 블로팅법을 실시함으로써, 당해 단백질의 발현을 검출하고, 유전자의 번역수준을 측정하는 것도 가능하다. 상기 유전자에 의해 코드되는 단백질의 검출에 사용하는 항체로서는, 검출가능한 항체이면 특히 제한은 없지만, 예를 들어 모노클로날 항체 또는 폴리클로날 항체의 양방을 이용할 수 있다.
본 방법에 있어서는, 또, 시험 화합물의 비존재하에 있어서 측정한 경우(대조)와 비교하여, 당해 발현수준을 저하시키는 화합물을 선택한다. 이와 같이 하여 선택된 화합물은, 암세포에 대해 아포토시스를 유도하는 작용을 갖는 것이 기대된다. 또, 당해 화합물은, 아포토시스 유도를 작용 기작으로 하는 제암제(항암제)가 되는 것이 기대된다.
본 발명의 방법의 또 다른 태양에 있어서는, 본 발명의 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)의 발현수준을 저하시키는 화합물을 리포터 유전자를 이용하여 스크리닝하는 방법이다.
본 방법에 있어서는, 우선, 상기 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)의 전사조절영역과 리포터 유전자가 기능적으로 결합한 구조를 갖는 DNA를 포함하는 세포 또는 세포 추출액과 시험 화합물을 접촉시킨다. 여기서, 「기능적으로 결합한」이란, 상기 염색체 안정화 관련 유전자의 전사조절영역에 전사인자가 결합함으로써, 리포터 유전자의 발현이 유도되도록, 당해 유전자의 전사조절영역과 리포터 유전자가 결합되어 있는 것을 말한다. 따라서, 리포터 유전자가 다른 유전자와 결합하고 있고, 다른 유전자 산물과의 융합 단백질을 형성하는 경우이어도, 당해 유전자의 전사조절영역에 전사인자가 결합함으로써, 당해 융합 단백질의 발현이 유도되는 것이면, 상기 「기능적으로 결합한」의 뜻에 포함된다. 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)의 cDNA 염기배열에 기초하여, 당업자에 있어서는, 게놈 중에 존재하는 당해 유전자의 전사조절영역을 주지의 방법에 의해 취득하는 것이 가능하다.
본 방법에 사용하는 리포터 유전자로서는, 그 발현이 검출가능하면 특히 제한되지 않고, 예를 들어 CAT 유전자, lacZ 유전자, 루시페라아제 유전자 및 GFP 유전자 등을 들 수 있다. 「염색체 안정화 관련 유전자의 전사조절영역과 리포터 유전자가 기능적으로 결합한 구조를 갖는 DNA를 포함하는 세포」로서, 예를 들어 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)의 전사조절영역과 리포터 유전자가 기능적으로 결합한 구조를 갖는 벡터가 도입된 세포 등을 들 수 있다. 상기 벡터는, 당업자에 있어서는 일반적인 유전자 공학기술에 의해 제작할 수 있다. 벡터의 세포에의 도입은, 일반적인 방법, 예를 들어 인산칼슘 침전법, 전기펄스 천공법, 리포펙타민법, 마이크로 인젝션법 등에 의해 실시할 수 있다. 「염색체 안정화 관련 유전자의 전사조절영역과 리포터 유전자가 기능적으로 결합한 구조를 갖는 DNA를 포함하는 세포」에는, 염색체에 당해 구조가 삽입된 세포도 포함된다. 염색체에의 DNA 구조의 삽입은, 당업자에게 일반적으로 사용되는 방법, 예를 들어 무작위 삽입이나, 상동 재조합을 이용한 유전자 도입법에 의해 행할 수 있다.
「염색체 안정화 관련 유전자의 전사조절영역과 리포터 유전자가 기능적으로 결합한 구조를 갖는 DNA를 포함하는 세포추출액」이란, 예를 들어 시판의 시험관 내 전사번역 키트에 포함되는 세포추출액에, 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)의 전사조절영역과 리포터 유전자가 기능적으로 결합한 구조를 갖는 DNA를 첨가한 것을 들 수 있다.
본 방법에서의 「접촉」은, 「염색체 안정화 관련 유전자의 전사조절영역과 리포터 유전자가 기능적으로 결합한 구조를 갖는 DNA를 포함하는 세포」의 배양액에 시험 화합물을 첨가하거나, 또는 당해 DNA를 포함하는 상기 시판된 세포추출액에 시험 화합물을 첨가함으로써 행할 수 있지만, 이들의 방법에 한정되지 않는다. 시험 화합물이 단백질의 경우에는, 예를 들어 당해 단백질을 발현하는 DNA 벡터를 당해 세포에 도입함으로써 접촉을 하는 것도 가능하다.
본 방법에 있어서는, 다음에, 당해 리포터 유전자의 발현수준을 측정한다. 리포터 유전자의 발현수준은, 당해 리포터 유전자의 종류에 따라, 당업자에게 주지의 방법에 의해 측정할 수 있다. 예를 들어, 리포터 유전자가 CAT유전자인 경우에는, 당해 유전자 산물에 의한 클로람페니콜의 아세틸화를 검출함으로써, 리포터 유전자의 발현량을 측정할 수 있다. 리포터 유전자가 1acZ 유전자인 경우에는, 당해 유전자 발현 산물의 촉매작용에 의한 색소화합물의 발색을 검출함으로써, 또한, 루시페라아제 유전자인 경우에는, 당해 유전자 발현 산물의 촉매작용에 의한 형광화합물의 형광을 검출함으로써, 또, GFP유전자인 경우에는, GFP단백질에 의한 형광을 검출함으로써, 리포터 유전자의 발현량을 측정할 수 있다.
본 방법에 있어서는, 다음에, 측정한 리포터 유전자의 발현수준을, 시험 화합물의 비존재하에 있어서 측정한 경우와 비교하여, 저하시키는 화합물을 선택한다. 이와 같이 하여 선택된 화합물은, 암세포 특이적 아포토시스 유도제가 된다.
본 발명의 방법의 다른 태양에 있어서는, 본 발명의 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)에 의해 코드되는 단백질의 활성을 지표로 하는 화합물의 스크리닝 방법이다.
본 방법에 있어서는, 우선 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)에 의해 코드되는 단백질, 또는 당해 단백질을 발현하는 세포 또는 세포추출액과 시험 화합물을 접촉시킨다. 다음에, 당해 단백질의 활성을 측정한다. 당해 단백질의 활성으로서는, 예를 들어 상기 (a)~(r)에 나타낸 기능(활성) 등을 들 수 있다. 당업자에 있어서는, 스크리닝에 있어서 지표로 하는 단백질에 대한 기능(활성) 및 당해 기능(활성)의 평가(측정)방법에 대한 정보를, 예를 들어 문헌 데이터베이스 등에 의해 적절히 입수할 수 있다.
일례를 나타내면, 지표가 되는 단백질이 Mcm10인 경우는, 예를 들어 ARS(Autonomously replicating sequences)의 거동을 이차원 전기영동으로 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(MCB(1997)3261-3271.).
지표가 되는 단백질이 Orc1인 경우는, 예를 들어 당해 단백질을 포함하는 Orc1-6의 복합체 형성, 혹은 CaCl2 존재하에서의 Orc1-6 복합체의 전기영동적 이동도의 변화를 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(JBC(1998)273,32421-32429).
지표가 되는 단백질이 Orc3인 경우는, 예를 들어 당해 단백질을 포함하는 Orc1-6의 복합체 형성, 당해 단백질의 Ori 특이적인 결합을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(JCB(1998)273,32421-32429.).
지표가 되는 단백질이 Cdc6인 경우는, 예를 들어 무세포 DNA 복제 분석을 이용하여 당해 단백질의 기능을 평가(측정)할 수 있다(EMBO(1998)17,7219-7229.).
지표가 되는 단백질이 Cdt1인 경우는, 예를 들어 당해 단백질과 Geminin의 결합을 검출함으로써, 혹은 무세포 DNA 복제 분석을 이용하여 당해 단백질의 기능을 평가(측정)할 수 있다(Science(2000)290,2309-2312.).
지표가 되는 단백질이 Geminin인 경우는, 예를 들어 무세포 DNA 복제 분석을 이용한 DNA 복제 저해 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Cell(1998)93,1043-1053.).
지표가 되는 단백질이 Mcm3인 경우는, 예를 들어 당해 단백질을 포함하는 Mcm2,3,5 복합체에 의한 Mcm4,6,7의 헬라카아제 활성 저해 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(JBC(1998)273,8369-8375.).
지표가 되는 단백질이 Mcm4인 경우는, 예를 들어 당해 단백질을 포함하는 Mcm4,6,7 복합체에 의한 ssDNA 결합 활성, ATPase 활성, 헬라카아제 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(JBC(1997)272,24508-24513.).
지표가 되는 단백질이 Mcm5인 경우는, 예를 들어 당해 단백질을 포함하는 Mcm2,3,5 복합체에 의한 Mcm4,6,7의 헬리카아제 활성 저해 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(JBC(1998)273,8369-8375.).
지표가 되는 단백질이 Mcm6인 경우는, 예를 들어 당해 단백질을 포함하는 Mcm4,6,7 복합체에 의한 ssDNA 결합 활성, ATPase 활성, 헬라카아제 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(JBC(1997)272,24508-24513.).
지표가 되는 단백질이 Mcm7인 경우는, 예를 들어 당해 단백질을 포함하는 Mcm4,6,7 복합체에 의한 ssDNA 결합 활성, ATPase 활성, 헬라카아제 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(JBC(1997)272,24508-24513.).
지표가 되는 단백질이 Mcm8인 경우는, 예를 들어 당해 단백질과 Mcm4,6,7 복합체의 결합을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Nucleic.Acids Res.(2003)31,570-579.).
지표가 되는 단백질이 Cdc7인 경우는, 예를 들어 MCM 복합체를 기질로 한 당해 단백질의 인산화 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(EMBO(1997)16,4340-4351.).
지표가 되는 단백질이 cdc5인 경우는, 예를 들어 당해 단백질의 전사 활성화능을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(JBC(1998)273,4666-4671.).
지표가 되는 단백질이 Psf1인 경우는, 예를 들어 당해 단백질을 포함하는 Psf1-4와 Sld5에 의한 GINS 복합체 형성, GINS에 의한 Dpb11, Sld3, Cdc47의 Ori배열에의 결합을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Genes&Dev.(2003)17,1153-1165.).
지표가 되는 단백질이 Psf2인 경우는, 예를 들어 당해 단백질을 포함하는 Psf1-4와 Sld5에 의한 GINS 복합체 형성, GINS에 의한 Dpb11, Sld3, Cdc47의 Ori배열에의 결합을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Genes&Dev.(2003)17,1153-1165.).
지표가 되는 단백질이 Psf3인 경우는, 예를 들어 당해 단백질을 포함하는 Psf1-4와 Sld5에 의한 GINS 복합체 형성, GINS에 의한 Dpb11, Sld3, Cdc47의 Ori배열에의 결합을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Genes&Dev.(2003)17,1153-1165.).
지표가 되는 단백질이 Cdc45인 경우는, 예를 들어 당해 단백질과 Mcm7, Pola p70의 결합을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Eur.J.Biochem.265,936-943.).
지표가 되는 단백질이 Pola p180인 경우는, 예를 들어 당해 단백질을 포함하는 Pola p180, p70, p58, p48에 의한 4량체 형성 혹은 이 복합체의 프라머라아제(Primerase), 폴리머라아제 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Eur.J.Biochem.222,781-793.).
지표가 되는 단백질이 Pola p70인 경우는, 예를 들어 당해 단백질을 포함하는 Pola p180, p70, p58, p48에 의한 4량체 형성 혹은 이 복합체의 프리마아제(Primase), 폴리머라아제 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Eur.J.Biochem.222,781-793.).
지표가 되는 단백질이 Pola Spp1(p58)인 경우는, 예를 들어 당해 단백질을 포함하는 Pola p180, p70, p58, p48에 의한 4량체 형성 혹은 이 복합체의 프리마아제, 폴리머라아제 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Eur.J.Biochem.222,781-793.).
지표가 되는 단백질이 RPA70인 경우는, 예를 들어 당해 단백질의 ssDNA에의 결합을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Nature(1997)385,176-181.).
지표가 되는 단백질이 RPA34인 경우는, 예를 들어 당해 단백질의 ssDNA에의 결합을 검출함으로써, 혹은 당해 단백질을 포함하는 시험관 내 복제 분석을 이용하여 당해 단백질의 기능을 평가(측정)할 수 있다(JBC(1990)265,3177-3182.).
지표가 되는 단백질이 PCNA인 경우는, 예를 들어 당해 단백질을 포함하는 시험관 내 복제 분석을 이용하여 당해 단백질의 기능을 평가(측정)할 수 있다(JBC(1990)265,3177-3182.).
지표가 되는 단백질이 Ligase1인 경우는, 예를 들어 당해 단백질을 포함하는 DNA 연결 활성에 의해 당해 단백질의 기능을 평가(측정)할 수 있다(PNAS(1990)87,6679-6683.).
지표가 되는 단백질이 Pole Pol2인 경우는, 예를 들어 당해 단백질을 포함하는 Pole 정제표품의 DNA 합성 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(PNAS(1990)87,6664-6668.).
지표가 되는 단백질이 Pole Dpb3인 경우는, 예를 들어 당해 단백질을 포함하는 Pole 정제표품의 DNA 합성 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(PNAS(1990)87,6664-6668.).
지표가 되는 단백질이 Topoisomerase 1인 경우는, 예를 들어 플라스미드 DNA를 기질로 한 당해 단백질의 릴렉싱(relaxing) 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(PNAS(1988)85,2543-2547.).
지표가 되는 단백질이 TDP1인 경우는, 예를 들어 ssDNA의 3'말단에 결합시킨 티로신 잔기의 당해 단백질에 의한 유리 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Science(1999)286,552-555.).
지표가 되는 단백질이 FEN1인 경우는, 예를 들어 5'-오버행 플랩(flap) 구조를 갖는 이중쇄 DNA를 기질로 한 플랩 구조의 제거 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Genomics(1995)25,220-225.).
지표가 되는 단백질이 Pold P125인 경우는, 예를 들어 당해 단백질과 Pold P68, P50, P12의 헤테로 4량체 형성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Biochemistry.2002 41(44):13133-13142.).
지표가 되는 단백질이 Pole Dpb4인 경우는, 당해 단백질을 포함하는 Pole 정제표품의 DNA 합성 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(PNAS(1990)87,6664-6668.).
지표가 되는 단백질이 DNA2인 경우는, 예를 들어 ssDNA 결합능, ATPase 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(PNAS(1995)92,7642-7646.).
지표가 되는 단백질이 ATR인 경우는, 예를 들어 UV 손상부위를 갖는 이중쇄 DNA에의 당해 단백질의 결합, 혹은 p53 단백질을 기질로 한 당해 단백질에 의한 인산화를 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(PNAS(2002)99,6673-6678.).
지표가 되는 단백질이 Chk1인 경우는, 예를 들어 p53 단백질을 기질로 한 당해 단백질에 의한 인산화를 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Genes Dev.(2000)14,289-300).
지표가 되는 단백질이 NBS1인 경우는, 예를 들어 DNA 손상에 응답한 당해 단백질과 Mre11/Rad50의 복합체 형성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Cell(1998)93,477-486.).
지표가 되는 단백질이 Hus1인 경우는, 예를 들어 DNA 손상에 응답한 당해 단백질과 Rad1, Rad9의 복합체 형성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(JCB(1999)274,567-570.).
지표가 되는 단백질이 Rad1인 경우는, 예를 들어 DNA 손상에 응답한 당해 단백질과 Rad1, Rad9의 복합체 형성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(JCB(1999)274,567-570.).
지표가 되는 단백질이 Mad2인 경우는, 예를 들어 당해 단백질과 Mad1의 복합체 형성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Science 274(1996),246-248).
지표가 되는 단백질이 Ctf18인 경우는, 예를 들어 당해 단백질과 Ctf8, Dcc1의 복합체 형성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(JBC(2003),30051-30056.).
지표가 되는 단백질이 Scc1인 경우는, 예를 들어 당해 단백질과 Smc1, Smc3, Scc1의 14S cohesin 복합체 형성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(JCB(2000)151,749-761.).
지표가 되는 단백질이 Scc3인 경우는, 예를 들어 당해 단백질과 Smc1, Smc3, Scc1의 14S cohesin 복합체 형성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(JCB(2000)151,749-761.).
지표가 되는 단백질이 UNG인 경우는, 예를 들어 ssDNA 중의 데옥시우리딘을 기질로 한 글리코실라아제 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(EMBO(1989)8,3121-3125.).
지표가 되는 단백질이 MBD4인 경우는, 예를 들어 당해 단백질의 메틸화 CpG 배열에의 결합 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(MCB(1998)18,6538-6547.).
지표가 되는 단백질이 NTH1인 경우는, 예를 들어 당해 단백질의 글리코실라아제 활성이나 AP 분해효소(lyase) 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(PNAS(1997)94,109-114.).
지표가 되는 단백질이 NEIL2인 경우는, 예를 들어 염기에 손상을 갖는 DNA를 기질로 한 당해 단백질의 AP 분해효소 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(JBC(2002)277,30417-30420.).
지표가 되는 단백질이 NEIL3인 경우는, 예를 들어 8-oxo, AP site, 5-히드록시 시토신을 포함하는 DNA를 기질로 한 당해 단백질의 AP 분해효소 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Nucleic Acids Res.(2002)316,853-866.).
지표가 되는 단백질이 APE2인 경우는, 예를 들어 당해 단백질의 AP 엔도뉴클레아제 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(JMB(2002)316,853-866.).
지표가 되는 단백질이 PARP1인 경우는, 예를 들어 ADP-리보오스를 기질로 한 당해 단백질의 닉(nick) DNA에의 ADP-리보오스 폴리머라아제 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(JBC(1990)35,21907-21913.).
지표가 되는 단백질이 PNK인 경우는, 예를 들어 올리고(dT)를 기질로 한 폴리뉴클레오티드 키나아제 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(JBC(1999)274,24176-24186.).
지표가 되는 단백질이 Polb인 경우는, 예를 들어 당해 단백질의 gap-filling 폴리머라아제 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Biochemistry(1988),901-909.).
지표가 되는 단백질이 MGMT인 경우는, 예를 들어 당해 단백질에 의한 메틸화 DNA로부터의 메틸기 전이반응을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(JBC(1990)265,14754-14762.).
지표가 되는 단백질이 TDG인 경우는, 예를 들어 당해 단백질에 의한 미스매치 티미딘의 절단 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(JBC(1993)268,21218-21224.).
지표가 되는 단백질이 MSH2인 경우는, 예를 들어 당해 단백질의 미스매치를 포함하는 이중쇄 DNA에의 결합을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Cancer Res.(1994)54,5539-5542.).
지표가 되는 단백질이 PMS1인 경우는, 예를 들어 당해 단백질의 DNA 결합능, ATPase 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Nucleic Acids Res.(2003)31,2025-2034.).
지표가 되는 단백질이 PMS2인 경우는, 예를 들어 당해 단백질과 MLH1의 상호작용을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Hum. Mutat.19,108-113.).
지표가 되는 단백질이 Exonuclease 1인 경우는, 예를 들어 당해 단백질의 엑소뉴클레아제 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Nucleic Acids Res.(1998)26,3762-3768.).
지표가 되는 단백질이 XPC인 경우는, 예를 들어 당해 단백질의 ssDNA에의 결합능을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(EMBO(1994)15,1831-1843.).
지표가 되는 단백질이 Rad23A인 경우는, 예를 들어 당해 단백질의 N말단에서의 26S 프로테아좀과의 상호작용, C말단에서의 Rad4와의 결합을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Nature(1998)391,715-718.).
지표가 되는 단백질이 Rad23B인 경우는, 예를 들어 당해 단백질의 N말단에서의 26S 프로테아좀과의 상호작용, C말단에서의 Rad4와의 결합을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Nature(1998)391,715-718.).
지표가 되는 단백질이 CSA인 경우는, 예를 들어 당해 단백질과 CSB, TFIIH의 상호작용을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Cell(1995)82,555-564.).
지표가 되는 단백질이 CSB인 경우는, 예를 들어 당해 단백질의 DNA 의존적 ATPase 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(JBC(1997)272,1885-1890.).
지표가 되는 단백질이 XPG인 경우는, 예를 들어 버블구조를 갖는 부분적인 duplex를 기질로 한 당해 단백질의 엔도뉴클레아제 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Nature(1994)371,423-425.).
지표가 되는 단백질이 XPF인 경우는, 예를 들어 당해 단백질과 ERCC1의 복합체 형성, 스템-루프(stem-loop) 구조 DNA를 기질로 한 당해 단백질의 엔도뉴클레아제 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Cell(1996)86,811-822.).
지표가 되는 단백질이 DDB1인 경우는, 예를 들어 당해 단백질의 UV조사 DNA에의 결합을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(JBC(1993)268,21293-21300.).
지표가 되는 단백질이 XAB2인 경우는, 예를 들어 당해 단백질과 XPA, CSA, CSB, RNA 폴리머라아제 II의 상호작용을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(JBC(2000)275,34931-34937.).
지표가 되는 단백질이 DDB2인 경우는, 예를 들어 당해 단백질의 UV 손상 DNA에의 결합 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(DNA repair(2002)6,601-616.).
지표가 되는 단백질이 Topoisomerase IIIb인 경우는, 예를 들어 RecQ5 헬리카아제와의 상호작용을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Nucleic Acids Res.(2000)28,1647-1655.).
지표가 되는 단백질이 Rad51인 경우는, 예를 들어 당해 단백질의 ssDNA 의존성 ATPase 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(JBC(2002)277,14417-14425.).
지표가 되는 단백질이 Rad51D인 경우는, 예를 들어 당해 단백질을 포함하는 Rad51B/Rad51C/Rad51D/Xrcc2 복합체의 ssDNA에의 결합능, ssDNA 의존적 ATPase 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Genes. Dev.(2001)15,329-3307.).
지표가 되는 단백질이 XRCC2인 경우는, 예를 들어 당해 단백질을 포함하는 Rad51B/Rad51C/Rad51D/Xrcc2 복합체의 ssDNA에의 결합능, ssDNA 의존적 ATPase 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Nature(1999)401,397-399.).
지표가 되는 단백질이 Rad54인 경우는, 예를 들어 당해 단백질의 DNA 의존적 ATPase 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Curr. Biol(1996)6,828-838.).
지표가 되는 단백질이 BRCA1인 경우는, 예를 들어 당해 단백질의 E3 유비퀴틴 리가아제 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(EMBO J.(2002)21,6755-6762.).
지표가 되는 단백질이 Ku80인 경우는, 예를 들어 당해 단백질의 DNA 말단에의 결합 및 Ku70와의 복합체 형성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(PNAS(1990)87,1777-1781.).
지표가 되는 단백질이 XRCC4인 경우는, 예를 들어 당해 단백질과 Ligase4의 결합 및 당해 단백질의 DNA 결합을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Cell(1995)83,1079-1089.).
지표가 되는 단백질이 Ubc13인 경우는, 예를 들어 당해 단백질의 유비퀴틴 접합 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Cell(1999)96,645-653.).
지표가 되는 단백질이 Rad6A인 경우는, 예를 들어 당해 단백질과 Rad18의 복합체 형성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(PNAS(1991)88,8865-8869.).
지표가 되는 단백질이 Rad18인 경우는, 예를 들어 당해 단백질의 DNA 결합을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Nucleic. Acids Res.(2000)28,2847-2854.).
지표가 되는 단백질이 FBH1인 경우는, 예를 들어 당해 단백질의 헬라카아제 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(JCB(2002)277,24530-24537.).
지표가 되는 단백질이 Poli인 경우는, 예를 들어 미스매치 부분적인 duplex DNA로부터의 프라이머 연장 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(JBC(2001)276,30615-30622.).
지표가 되는 단백질이 DUT1인 경우는, 예를 들어 당해 단백질의 dUTPase 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(J.Biol.Chem., (1996)271,7745-7751.).
지표가 되는 단백질이 Tin2인 경우는, 예를 들어 당해 단백질과 TRF1의 상호작용을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Nat Genet(1999)23,405-412.).
지표가 되는 단백질이 Sir2인 경우는, 예를 들어 당해 단백질의 히스톤 탈아세틸화 분석에 의해 당해 단백질의 기능을 평가(측정)할 수 있다(Gene(1999)234,161-168.).
지표가 되는 단백질이 Elg1인 경우는, 예를 들어 당해 단백질과 RFC2, RFC3, RFC4, RFC5의 복합체 형성을 검출함으로써, 당해 단백질의 기능을 평가할 수 있다(EMBO J.(2003)22,4304-4313.).
지표가 되는 단백질이 TIMELESS인 경우는, 예를 들어 당해 단백질과 mammalian clock Period proteins(mPERs)의 복합체 형성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Science(2003)302,439-442.).
지표가 되는 단백질이 Pif1인 경우는, 예를 들어 당해 단백질의 ATP 의존적 헬라카아제 활성, DNA 의존적 ATPase 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다.
지표가 되는 단백질이 Mms4인 경우는, 예를 들어 당해 단백질과 Mus81 단백질의 복합체가 갖는 엔도뉴클레아제 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(JBC(2003)278,21715-21720.).
지표가 되는 단백질이 Topoisomerase IIIa인 경우는, 예를 들어 당해 단백질의 국소이성화효소(topoisomerase) 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Nucleic Acids Res.(2002)30,4823-4829.).
지표가 되는 단백질이 Mus81인 경우는, 예를 들어 당해 단백질과 Mms4 단백질의 복합체가 갖는 엔도뉴클레아제 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(JBC(2003)278,21715-21720.).
지표가 되는 단백질이 SIRT1인 경우는, 예를 들어 당해 단백질의 NAD 의존성 히스톤 탈아세틸화효소를 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Nature(2000)403,795-800.).
지표가 되는 단백질이 ESP1인 경우는, 예를 들어 당해 단백질의 프로테아제 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(FEBS Lett.(2002)528,246-250.).
지표가 되는 단백질이 MPG인 경우는, 예를 들어 당해 단백질의 글리코실라아제 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Carcinogenesis(1996)17,2177-2182.).
지표가 되는 단백질이 Poll인 경우는, 예를 들어 당해 단백질의 DNA 폴리머라아제 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(J Biol Chem.(2000)275,31233-31238.).
지표가 되는 단백질이 Polm인 경우는, 예를 들어 당해 단백질의 DNA 폴리머라아제 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(J Biol Chem.(2002)277,44582-44587.).
지표가 되는 단백질이 Endo V인 경우는, 예를 들어 당해 단백질의 엔도뉴클레아제 활성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다.
지표가 되는 단백질이 KNTC2(NDC80)인 경우는, 예를 들어 당해 단백질과 인간 Nuf2 단백질의 복합체 형성을 검출함으로써, 당해 단백질의 기능을 평가(측정)할 수 있다(Mol Biol Cell.(2005)16,519-531.).
다음에, 시험 화합물의 비존재하에 있어서 측정한 경우와 비교하여, 염색체 안정화 관련 유전자에 의해 코드되는 단백질의 활성을 저하시키는 화합물을 선택한다. 상기 방법에 사용하는 당해 유전자에 의해 코드되는 단백질은, 변이를 포함하지 않는 전체길이 단백질인 것이 바람직하지만, 당해 단백질과 동등한 활성을 갖는 것이면, 일부의 아미노산 배열이 치환 및/혹은 결실된 단백질이어도 된다.
또한, 본 발명은, 본 발명의 암세포 특이적 아포토시스 유도제를 유효성분으로서 함유하는 항암제(암치료를 위한 의약조성물)를 제공한다.
또, 본 발명은, 아포토시스 유도제 또는 항암제를 의약조성물로서 제조하는 방법을 제공한다. 본 방법에 있어서는, 우선, 본 발명의 상기 스크리닝 방법에 의해, 암세포 특이적 아포토시스 유도제가 되는 화합물을 선택한다. 다음에, 선택된 화합물을 약학상 허용되는 담체와 혼합한다. 이들 약학상 허용되는 담체로서, 예를 들어 계면활성제, 부형제, 착색료, 착향료, 보존료, 안정제, 완충제, 현탁제, 등장화제, 결합제, 붕괴제, 활택제, 유동성 촉진제, 교미제 등을 들 수 있는데, 이들에 제한되지 않고, 그 밖의 상용의 담체를 적절히 사용할 수 있다.
본 발명의 아포토시스 유도제 또는 항암제 등의 약제의 제제(製劑)화에 있어서는, 상법에 따라, 필요에 따라 상기 담체를 첨가할 수 있다. 구체적으로는, 경질무수규산, 유당, 결정 셀룰로오스, 만니톨, 전분, 카르멜로스 칼슘, 카르멜로스 나트륨, 히드록시프로필셀룰로오스, 히드록시프로필메틸셀룰로오스, 폴리비닐아세탈디에틸아미노아세테이트, 폴리비닐피롤리돈, 젤라틴, 중쇄 지방산 트리글리세라이드, 폴리옥시에틸렌 경화 히마시유60, 백설탕, 카르복시메틸셀룰로오스, 콘스타치, 무기염류 등을 들 수 있다.
상기 약제의 제형의 종류로서는, 예를 들어 경구제로서 정제, 분말제, 환제, 산제, 과립제, 세립제, 연·경 캡슐제, 필름 코팅제, 펠렛제, 설하제, 페이스트제 등, 비경구제로서 주사제, 좌제, 경피제, 연고제, 경고제, 외용액제 등을 들 수 있고, 당업자에 있어서는 투여경로나 투여대상 등에 따른 최적의 제형을 선택할 수 있다. 염색체 안정화 관련 유전자(예를 들어, 상기 어느 하나에 기재된 유전자)에 의해 코드되는 단백질을 발현하는 DNA, 염색체 안정화 관련 유전자를 억제하는 안티센스 RNA, 리보자임, siRNA를 발현하는 DNA를 생체 내에 투여하는 경우, 레트로바이러스, 아데노바이러스, 센다이바이러스 등의 바이러스 벡터나 리포솜 등의 비바이러스 벡터를 이용할 수 있다. 또한, 염색체 안정화 관련 유전자를 억제하는 합성 안티센스 핵산이나 합성 siRNA를 생체 내에 투여하는 경우, 리포솜, 고분자 미셀, 양이온성 캐리어 등의 비바이러스 벡터를 이용할 수 있다. 투여방법으로서는, 예를 들어 in vivo법 및 ex vivo법을 들 수 있다.
본 발명에는, 아포토시스 유도작용을 갖는 상기 의약조성물도 포함된다.
본 발명의 약제 또는 의약조성물의 투여량은, 제형의 종류, 투여방법, 환자의 연령이나 체중, 환자의 증상 등을 고려하여, 최종적으로는 의사의 판단에 의해 적절히 결정할 수 있다.
또한, 본 발명은, 원하는 암세포에 대해서 아포토시스를 유도하는 방법에 관한 것이다. 당해 방법의 바람직한 태양으로서는, 아포토시스를 유도하고자 하는 세포(대상 세포)에 본 발명의 아포토시스 유도제를 투여하는(접촉시키는) 공정을 포함하는 당해 세포의 아포토시스를 유도하는 방법이다. 예를 들어, 본 발명의 아포토시스 유도제의 유효성분이 핵산인 경우에는, 당해 약제(핵산)를 대상 세포 내에 도입시키는 것이 바람직하다.
또, 본 발명은, 본 발명의 아포토시스 유도제 또는 본 발명의 항암제를 개체(암환자 등)에 투여하는 공정을 포함하는 암의 치료방법에 관한 것이다.
상기 치료방법에서의 개체란, 통상 암질환의 환자를 가리키고, 특히 제한되지 않지만, 바람직하게는 인간이다. 개체에의 투여는, 일반적으로는, 예를 들어 동맥 내 주사, 정맥 내 주사, 피하 주사 등 당업자에게 주지의 방법에 의해 행할 수 있다. 투여량은, 환자의 체중이나 연령, 투여방법 등에 의해 변동하지만, 당업자이면 적당한 투여량을 적절히 선택하는 것이 가능하다. 또한, 당해 화합물이 DNA에 의해 코드될 수 있는 것이면, 당해 DNA를 유전자 치료용 벡터에 내장하고, 유전자 치료를 행하는 것도 생각된다. 유전자 치료용 벡터로서는, 예를 들어 레트로바이러스 벡터, 아데노바이러스 벡터, 아데노수반 바이러스 벡터 등의 바이러스 벡터나 리포솜 등의 비바이러스 벡터 등을 예시할 수 있다. 당해 벡터를 이용하여, ex vivo법이나 in vivo법 등에 의해 환자에 목적의 DNA의 투여를 행할 수 있다. 또한, 본 발명의 핵산을 직접 개체에 투여하는 것도 가능하다.
또, 본 발명은, 염색체의 안정화를 저해하는 화합물(예를 들어, 본 발명의 유전자의 발현 또는 당해 유전자에 의해 코드되는 단백질의 기능을 억제하는 화합물 등)의 아포토시스 유도제 또는 항암제의 제조에서의 사용에 관한 것이다.
또, 본 명세서에 있어서 인용된 모든 선행기술문헌은, 참조로서 본 명세서에 내장된다.
도 1은, 실시예에서 사용한 유전자명, 액세션 번호(Accession no.), siRNA 배열, 배열번호, HeLa 세포에서의 유전자 발현 억제, MTT 분석(HeLa 세포), Tunel법의 결과, TIG3 세포에서의 유전자 발현 억제, MTT 분석(TIG3 세포)을 나타낸다. 「HeLa 세포에서의 유전자 발현 억제」의 열은, 각 유전자에 대한 siRNA를 각각 HeLa 세포에 도입하고, 도입 48시간 후의 각 mRNA의 발현을 Taqman PCR에 의해 정량한 결과를 나타낸다. 「MTT 분석(HeLa 세포)」의 열은, 각 유전자에 대한 siRNA를 HeLa 세포에 도입하고, 도입 4일 후의 세포 생존율을 MTT 분석으로 조사한 결과를 나타낸다. 「Tunel법」의 열은, 염색이 인정된 경우, 즉 아포토시스 양성의 경우를 YES로 표시하였다. 「TIG3 세포에서의 유전자 발현 억제」의 열은, 각 유전자에 대한 siRNA를 TIG3 세포에 도입하고, 72시간 후의 mRNA의 발현을 Taqman PCR에 의해 정량한 결과를 나타낸다. ND는 검출 불가능을 나타낸다. 「MTT 분석(TIG3 세포)」의 열은, 각 유전자에 대한 siRNA를 각각 TIG3 세포에 도입하고, 4일 후의 세포 생존율을 MTT 분석으로 조사한 결과를 나타낸다. 또, 유전자는 각각이 갖는 기 능에 따라 분별하였다.
도 2는, 도 1의 계속도이다.
도 3은, 도 2의 계속도이다.
도 4는, 도 3의 계속도이다.
도 5는, HeLa 세포에서의 각 유전자의 mRNA 발현의 억제에 의한 아포토시스의 유도를 나타내는 사진이다. 각 유전자에 대한 siRNA를 각각 HeLa 세포에 도입하고, TUNEL법을 이용하여 도입 48시간 후의 HeLa 세포에서의 아포토시스 유도를 검토한 결과를 나타낸다. 각 도면의 왼쪽의 녹색(흑백 도면을 게재)은 아포토시스가 유도된 핵을, 각 도면의 오른쪽은 시야에 존재하는 세포의 핵을 나타낸다.
도 6은, 도 5의 계속 사진이다.
도 7은, 도 6의 계속 사진이다.
도 8은, 도 7의 계속 사진이다.
도 9는, 도 8의 계속 사진이다.
도 1O은, 안티-ssDNA 항체를 이용하여 염색체 DNA 중의 1개 쇄 DNA가 노출한 영역을 면역 염색한 결과를 나타내는 사진이다. 1 유전자에 대해, 3장 세트의 사진을 나타낸다. 왼쪽부터 안티-ssDNA상, 핵 염색상, 이중 상이다.
도 11은, 도 10의 계속도이다.
도 12는, 도 11의 계속도이다.
도 13은, 도 12의 계속도이다.
도 14는, 도 13의 계속도이다.
도 15는, 도 14의 계속도이다.
도 16은, 도 15의 계속도이다.
도 17은, 도 16의 계속도이다.
도 18은, 도 17의 계속도이다.
도 19는, 도 18의 계속도이다.
도 20은, 도 19의 계속도이다.
도 21은, 도 20의 계속도이다.
도 22는, 도 21의 계속도이다.
도 23은, 도 22의 계속도이다.
도 24는, 도 23의 계속도이다.
도 25는, 도 24의 계속도이다.
도 26은, 도 25의 계속도이다.
도 27은, 도 26의 계속도이다.
도 28은, 실시예에서 사용한 유전자명, 액세션 번호(액세션 No.), 그 밖의 액세션 No., siRNA 배열, 배열번호, HeLa 세포에서의 유전자 발현 억제, HeLa 세포에서의 증식 억제, TIG3 세포에서의 유전자 발현 억제, TIG3 세포에서의 증식 억제를 나타낸다. 「40nM HeLa 세포에서의 유전자 발현 억제」의 열은, 각 유전자에 대한 siRNA 배열을 각각 HeLa 세포에 도입하고, 도입 48시간 후의 각 mRNA의 발현을 Taqman PCR에 의해 정량한 결과를 나타낸다. 「40nM HeLa 세포에서의 증식 억제」의 열은, 각 유전자에 대한 siRNA 배열을 각각 HeLa 세포에 도입하고, 도입 4일 후 의 세포 생존율을 MTT 분석으로 조사한 결과를 나타낸다. 「40nM TIG3 세포에서의 유전자 발현 억제」의 열은, 각 유전자에 대한 siRNA를 TIG3 세포에 도입하고, 72시간 후의 mRNA의 발현을 Taqman PCR에 의해 정량한 결과를 나타낸다. 또, 도면 중의 「**」은 “미결정(Not determined)”을 나타낸다. 「40nM TIG3 세포에서의 증식 억제」의 열은, 각 유전자에 대한 siRNA 배열을 각각 TIG3 세포에 도입하고, 도입 4일 후의 세포 생존율을 MTT 분석으로 조사한 결과를 나타낸다. 또, 유전자는 각각이 갖는 기능에 따라 분별하였다.
도 29는, 도 28의 계속도이다.
도 30은, 도 29의 계속도이다.
도 31은, KNTC2(NDC80) 유전자의 별명, 액세션 번호(액세션 No.), mRNA 등록, siRNA ID, siRNA 배열, 배열번호, HeLa 세포에서의 mRNA 발현, HeLa 세포에서의 증식 억제, HeLa 세포에서의 아포토시스, HDF 세포에서의 mRNA 발현, HDF 세포에서의 증식 억제, HDF 세포에서의 아포토시스를 나타낸다. HeLa 세포에서의 「mRNA 발현」의 열은, KNTC2(NDC80) 유전자에 대한 siRNA 배열을 각각 HeLa 세포에 도입하고, 도입 48시간 후의 각 mRNA의 발현을 Taqman PCR에 의해 정량한 결과를 나타낸다. HeLa 세포에서의 「증식 억제」의 열은, KNTC2(NDC80) 유전자에 대한 siRNA 배열을 각각 HeLa 세포에 도입하고, 도입 4일 후의 세포 생존율을 MTT 분석으로 조사한 결과를 나타낸다. HeLa 세포에서의 「아포토시스」의 열은, 염색이 인정된 경우, 즉 아포토시스 양성의 경우를 YES로 표시하였다. HDF 세포에서의 「mRNA 발현」의 열은, KNTC2(NDC80) 유전자에 대한 siRNA 배열을 각각 HDF 세포에 도입하고, 도입 48시간 후의 각 mRNA의 발현을 Taqman PCR에 의해 정량한 결과를 나타낸다. HDF 세포에서의 「증식 억제」의 열은, KNTC2(NDC80) 유전자에 대한 siRNA 배열을 각각 HDF 세포에 도입하고, 도입 4일 후의 세포 생존율을 MTT 분석으로 조사한 결과를 나타낸다. HDF 세포에서의 「아포토시스」의 열은, 염색이 인정된 경우, 즉 아포토시스 양성의 경우를 YES로 표시하였다.
도 32는, 실시예에서 사용한 유전자명, siRNA ID, siRNA 배열, 배열번호, HeLa 세포에서의 mRNA 발현, HeLa 세포에서의 증식 억제, HeLa 세포에서의 아포토시스, HDF 세포에서의 mRNA 발현, HDF 세포에서의 증식 억제, HDF 세포에서의 아포토시스를 나타낸다. HeLa 세포에서의 mRNA「발현」의 열은, 각 유전자에 대한 siRNA 배열을 각각 HeLa 세포에 도입하고, 도입 48시간 후의 각 mRNA의 발현을 Taqman PCR에 의해 정량한 결과를 나타낸다. HeLa 세포에서의 「증식」억제의 열은, 각 유전자에 대한 siRNA 배열을 각각 HeLa 세포에 도입하고, 도입 4일 후의 세포 생존율을 MTT 분석으로 조사한 결과를 나타낸다. HeLa 세포에서의 「아포토시스」의 열은, 염색이 인정된 경우, 즉 아포토시스 양성의 경우를 +(플러스)로 표시하였다. HDF 세포에서의 mRNA「발현」의 열은, 각 유전자에 대한 siRNA 배열을 각각 HDF 세포에 도입하고, 도입 48시간 후의 각 mRNA의 발현을 Taqman PCR에 의해 정량한 결과를 나타낸다. HDF 세포에서의 「증식」억제의 열은, 각 유전자에 대한 siRNA 배열을 각각 HDF 세포에 도입하고, 도입 4일 후의 세포 생존율을 MTT 분석으로 조사한 결과를 나타낸다. HDF 세포에서의 「아포토시스」의 열은, 염색이 인정된 경우, 즉 아포토시스 양성의 경우를 +(플러스), 아포토시스 음성의 경우를 -(마 이너스)로 표시하였다.
도 33은, HeLa 세포 및 TIG3 세포에서의 Pif1, Mms4, TopoisomeraseIIIa, Mus81, SIRT1(Sirtuin), Esp1, MPG, Poll, Polm, EndoV의 각 유전자의 mRNA 발현의 억제에 의한 아포토시스의 유도를 나타내는 사진이다. 각 유전자에 대한 siRNA를 각각 HeLa 세포 및 TIG3 세포에 도입하고, TUNEL법을 이용하여 도입 48시간 후의 HeLa 세포 및 도입 72시간 후의 TIG3 세포에서의 아포토시스 유도를 검토한 결과를 나타낸다.
도 34는, 도 33의 계속 사진이다.
도 35는, HeLa 세포 및 TIG3 세포에서의 KNTC2(NDC80) 유전자의 mRNA 발현의 억제에 의한 아포토시스의 유도를 나타내는 사진이다. KNTC2(NDC80) 유전자에 대한 siRNA를 각각 HeLa 세포 및 TIG3 세포에 도입하고, TUNEL법을 이용하여 도입 48시간 후의 HeLa 세포 및 도입 72시간 후의 TIG3 세포에서의 아포토시스 유도를 검토한 결과를 나타낸다. 좌측의 사진에는 아포토시스가 유도된 핵이 찍혀 있다. 우측의 사진에는 시야에 존재하는 세포의 핵이 찍혀 있다.
도 36은, 안티-ssDNA 항체를 이용하여 염색체 DNA 중의 1개 쇄 DNA가 노출한 영역을 면역 염색한 결과를 나타내는 사진이다.
이하, 실시예에 의해 본 발명을 구체적으로 설명하는데, 본 발명은 이것에 한정되는 것은 아니다.
본 실시예에 있어서 「염색체 안정화에 관련하는 유전자」로서 사용한 유전 자는, 이하에 나타내는 97개의 유전자이다:
APE2, ATR, BRCA1, Chk1, Cdc5, Cdc6, Cdc7, Cdc45, Cdt1, CSA, CSB, Ctf18, DDB1, DDB2, DNA2, DUT, Elg1, Endo V, Esp1, Exonuclease1, FBH1, FEN1, Geminin, Hus1, KNTC2(NDC80), Ku80, Ligase1, Mad2, MBD4, Mcm3, Mcm4, Mcm5, Mcm6, Mcm7, Mcm8, Mcm10, MGMT, MLH3, Mms4, MPG, MSH2, Mus81, NBS1, NEIL2, NEIL3, NTH1, Orc1, Orc3, PARP1, PCNA, Pif1, PMS1, PMS2, PNK, Pola p180, Pola p70, Pola Spp1(Prim2a), Polb, Pold p125, Pole Dpb3, Pole Dpb4, Pole Pol2, Poli, Poll, Polm, Psf1, Psf2, Psf3, Rad1, Rad18, Rad23A, Rad23B, Rad51, Rad51D, Rad54, Rad6A, RPA34, RPA70, Scc1, Scc3, Sir2, SIRT1(Sirtuin), TDG, TDP1, TIMELESS, Tin2, Topoisomerase I, Topoisomerase IIIa, Topoisomerase IIIb, Ubc13, UNG, XAB2, XPC, XPF, XPG, Xrcc2, XRCC4
〔실시예 1〕세포 배양
인간 배양세포로서, HeLa(인간 자궁경부암 세포), TIG3(정상 이배체 섬유아세포)를 사용하였다. 이들의 인간 배양세포를 10% 우태아 혈청, 50㎍/ml 겐타마이신을 포함하는 둘베코 변형 이글 배지에서 37도, 5% CO2 조건하에서 배양하였다.
〔실시예 2〕염색체 안정화에 관련하는 유전자의 발현 억제가 암세포의 증식에 미치는 영향의 검토
염색체 안정화에 관련하는 유전자의 발현 억제가 암세포의 증식에 미치는 영향을 검토할 목적으로, 상기 각 유전자에 대한 siRNA를 선정하였다. siRNA의 합성 은, 주식회사 키아겐(동경) 및 Dhamacon, Inc.(Colorado, USA)에 있어서 행해졌다.
상기 각 유전자의 siRNA 배열을 도 1~4의 「siRNA 배열」의 열에 나타낸다. 또, 배열표에는 센스 쇄만 기재하고, 대응하는 안티센스 쇄는 배열표에서 생략하였다. 또한, 각 siRNA 배열의 「dTdT」의 기재는 배열표에서는 「TT」로 생략하였다.
이들 siRNA를 인간 자궁경부암 유래 HeLa 세포에 도입하였다. 구체적으로는, siRNA의 트랜스펙션을 행하는 24시간 전에, 24웰 플레이트에 HeLa 세포를 파종하여 생착시키고, 20-50% 컨플루언트의 상태에서 트랜스펙션을 행하였다. 트랜스펙션 시약으로서 Oligofectoamine(Invitrogen)을 사용하고, 첨부하는 매뉴얼에 따라서 트랜스펙션을 행하였다. 도입 48시간 후에 상기 각 유전자의 mRNA의 발현을 Taqman PCR에 의해 정량하였다.
상세하게는, siRNA를 트랜스펙션 후, 48시간의 세포로부터 RNeasy Mini Kit(Qiagen)을 이용하여 모든 RNA를 추출하였다. 정량적 PCR에는, ABI PRISM 7000 Sequence Detection System(Applied Biosystems)를 사용하였다. 상기 각 유전자 및 β-액틴 유전자의 RT-PCR용 프라이머 및 TaqMan 프로브를 Applied Biosystems로부터 구입하였다. RT-PCR 반응시약으로서 TaqMan One-Step RT-PCR Master Mix Reagents Kit(Applied Biosystems)를 사용하고, 첨부하는 매뉴얼에 따라 RT-PCR을 행하였다. β-액틴을 표준으로서 이용하여 비교정량을 행하였다.
대조군 RNA(NS)를 도입한 세포에서의 각 mRNA의 발현을 100%로 하여, 각 siRNA를 도입한 세포에서의 각 mRNA의 발현을 비교한 바, 도 1~4의 「HeLa 세포에서의 유전자 발현 억제」의 열에 나타내는 바와 같이, 각 유전자에 대한 siRNA는 각각의 mRNA 발현을 효율적으로 억제하였다.
〔실시예 3〕HeLa 세포의 생존율
실시예 2에서 선정한 상기 각 유전자에 대한 siRNA를 각각 HeLa 세포에 도입하고, 도입 4일 후의 세포 생존율을 MTT 분석에 의해 조사하였다. 도입 96시간 후의 생세포수를 생세포수 측정시약 SF(Nacalai Tesque)를 이용하여 측정하였다.
그 결과, 도 1~4의 「MTT 분석(HeLa 세포)」의 열에 나타내는 바와 같이, 상기 각 유전자의 siRNA를 도입한 HeLa 세포에 있어서, 현저한 생존율의 저하가 인정되었다.
〔실시예 4〕siRNA의 HeLa 세포에서의 아포토시스 유도효과
상기 각 유전자에 대한 siRNA를 도입한 HeLa 세포에서의 생존율의 저하가 아포토시스에 의한 것인지 어떤지를 조사하였다. 각 유전자에 대한 siRNA를 각각 HeLa 세포에 도입하고, TUNEL법을 이용하여 도입 48시간 후의 HeLa 세포에서의 아포토시스 유도를 검토하였다.
결과, 도 1~4의 「Tunel법」의 열 및 도 5 내지 도 9의 사진에 나타내는 바와 같이, 상기 각 유전자에 대한 siRNA를 도입한 HeLa 세포 전부에 있어서, 현저하게 아포토시스의 유도가 인정되었다. 한편, 대조군 RNA(NS)가 도입된 HeLa 세포에서는 아포토시스의 유도는 인정되지 않았다(도 5의 좌상 「비특이적」).
즉, 본 발명의 상기 각 유전자의 발현을 억제함으로써, 효과적인 아포토시스의 유도가 일어나는 것이 명백하게 되었다.
〔실시예 5〕siRNA가 정상세포의 증식에 미치는 영향
상기 각 유전자에 대한 siRNA가 정상세포인 인간 태아폐 유래 이배체 섬유아세포 TIG3 세포의 증식에 미치는 영향을 검토하였다. 트랜스펙션 시약으로서 Lipofectoamine 2000(Invitrogen)을 사용하고, TIG3 세포에 상기 각 유전자에 대한 siRNA를 각각 도입하여, 도입 48시간 후에 상기 각 유전자의 mRNA의 발현을 Taqman PCR에 의해 측정하였다. 이 실험에서는 대조군 RNA(NS)를 도입한 TIG3 세포에서의 각 mRNA의 발현을 100%로 하여, 각 siRNA를 도입한 TIG3 세포에서의 각 mRNA의 발현을 비교하였다.
그 결과, 도 1~4의 「TIG3 세포에서의 유전자 발현 억제」의 열에 나타내는 바와 같이, 각 siRNA를 도입한 TIG3 세포에서는 상기 각 유전자의 mRNA의 발현은, 대조군 RNA(NS)를 도입한 TIG3 세포에서의 이들의 mRNA의 발현과 비교하여 현저하게 억제되어 있었다.
〔실시예 6〕TIG3 세포의 생존율
상기 siRNA를 각각 TIG3 세포에 도입하고, 도입 4일 후의 세포 생존율을 MTT 분석에 의해 조사하였다. 그 결과, 도 1~4의 「MTT 분석(TIG3 세포)」의 열에 나타내는 바와 같이, 상기 각 유전자에 대한 siRNA를 도입한 TIG3 세포의 생존율은, 당해 siRNA를 도입한 HeLa 세포의 생존율과 비교하여 높고, 현저한 저하는 인정되지 않았다.
상술한 결과로부터, 본 발명의 유전자의 발현을 억제함으로써, 암세포 특이적으로 아포토시스가 유도되는 것이라고 생각된다.
〔실시예 7〕항-단일쇄 DNA 항체를 이용한 게놈 붕괴과정의 해석
anti-ssDNA(항-단일쇄 DNA) 항체는, 1개 쇄 DNA를 특이적으로 인식하는 항체이다. 본래, 이중쇄로 이루어지는 DNA에 있어서, DNA 손상 등의 염색체 불안정화에 의해 게놈구조가 붕괴하면, 부분적으로 1개 쇄 영역이 노출된다고 한다. 따라서, 본 항체를 이용함으로써, 이 게놈의 붕괴과정을 특이적으로 인식하고, 가시화하는 것이 가능하다.
슬라이드 유리 상에 HeLa 세포를 파종하고, 상기 각 유전자에 대한 siRNA를 트랜스펙션하였다. siRNA 도입 약 30시간 후에 세포를 포르말린으로 고정하고, 1차 항체로서 anti-ssDNA 항체를 반응시켰다. anti-ssDNA 항체에 대한 형광표식 항체를 2차 항체로서 사용하고, 공초점 레이저 현미경으로 관찰하였다. 그 결과, 도 10~27에 나타내는 바와 같이, 1개 쇄 DNA를 갖는 핵이 녹색으로 염색되었다.
즉, 상기 각 유전자의 발현을 억제함으로써, 1개 쇄 DNA의 생성을 동반하는 DNA 손상이 생기는 것이 확인되었다.
〔실시예 8〕세포 배양
하기의 실시예에 있어서는, 「염색체 안정화에 관련하는 유전자」로서 이하에 나타내는 11개의 유전자를 사용하였다.
Pif1, Mms4, Topoisomerase IIIa, Mus81, SIRT1(Sirtuin), Esp1, MPG, Poll, Polm, EndoV, KNTC2(NDC80)
또한, 인간 배양 세포로서, 실시예 1에 기재된 HeLa 세포 및 TIG3 세포 외에, 정상세포로서 인간 피부 유래의 이배체 섬유아세포(HDF 세포)를 사용하였다. 배양은, 실시예 1과 같은 조건으로 행하였다.
〔실시예 9〕염색체 안정화에 관련하는 유전자의 발현 억제가 암세포의 증식에 미치는 영향의 검토
염색체 안정화에 관련하는 상기 11개의 유전자의 발현 억제가 암세포의 증식에 미치는 영향을 검토할 목적으로, 상기 각 유전자에 대한 siRNA를 선정하였다. siRNA의 합성은, 실시예 2와 같이 행하였다.
상기 11개의 각 유전자의 siRNA 배열을 도 28~32의 「siRNA 배열」의 열에 나타낸다. 또, 배열표에는 센스 쇄만 기재하고, 대응하는 안티센스 쇄는 배열표에서 생략하였다.
이들 siRNA를 HeLa 세포에 도입하였다. 구체적으로는, 실시예 2에 기재된 조건과 같이 하여 실시하였다. 도입 48시간 후에 상기 11 유전자의 mRNA의 발현을 Taqman PCR에 의해 정량하였다. 정량방법은 실시예 2와 같이 하여 행하였다.
대조군 RNA(NS)를 도입한 세포에서의 각 mRNA의 발현을 100%로 하여, 각 siRNA를 도입한 세포에서의 각 mRNA의 발현을 비교한 바, 도 28~30의 「40nM HeLa 세포에서의 유전자 발현 억제」의 열, 도 31의 HeLa 세포에서의 「mRNA 발현」의 열, 혹은 도 32의 HeLa 세포에서의 「발현」의 열에 나타내는 바와 같이, 각 유전자에 대한 siRNA는 각각의 mRNA 발현을 효율적으로 억제하였다.
〔실시예 10〕HeLa 세포의 생존율
상기 11개의 각 유전자에 대한 siRNA를 각각 HeLa 세포에 도입하고, 도입 4일 후의 세포 생존율을 MTT 분석에 의해 조사하였다. 도입 96시간 후의 생세포수를, 생세포수 측정시약 SF(Nacalai Tesque)를 이용하여 측정하였다.
그 결과, 도 28~30의 「40nM HeLa 세포에서의 증식 억제」의 열, 도 31의 HeLa 세포에서의 「증식 억제」의 열, 혹은 도 32의 HeLa 세포에서의 「증식」의 열에 나타내는 바와 같이, 상기 각 유전자의 siRNA를 도입한 HeLa 세포에 있어서 현저한 생존율의 저하가 인정되었다.
〔실시예 11〕siRNA의 HeLa 세포에서의 아포토시스 유도효과
상기 11개의 각 유전자에 대한 siRNA를 도입한 HeLa 세포에서의 생존율의 저하가 아포토시스에 의한 것인지 어떤지를 조사하였다. 각 유전자에 대한 siRNA를 각각 HeLa 세포에 도입하고, TUNEL법을 이용하여 도입 48시간 후의 HeLa 세포에서의 아포토시스 유도를 검토하였다.
결과, 도 31의 HeLa 세포에서의 「아포토시스」의 열, 도 32의 HeLa 세포에서의 「아포토시스」의 열, 또 도 33 및 34의 「HeLa 세포」의 사진 및 도 35의 HeLa 세포의 TUNEL염색의 사진에 나타내는 바와 같이, 상기 각 유전자에 대한 siRNA를 도입한 HeLa 세포 전부에 있어서 현저하게 아포토시스의 유도가 인정되었다.
즉, 본 발명의 상기 각 유전자의 발현을 억제함으로써, 효과적인 아포토시스의 유도가 일어나는 것이 명백하게 되었다.
〔실시예 12〕siRNA가 정상세포의 증식에 미치는 영향
상기 11개의 각 유전자에 대한 siRNA가 정상세포인 인간 태아폐 유래 이배체 섬유아세포 TIG3 세포 혹은 인간 피부 섬유아세포 HDF 세포의 증식에 미치는 영향을 검토하였다. 트랜스펙션 시약으로서 Lipofectoamine 2000(Invitrogen)을 사용하 고, TIG3 세포 혹은 HDF 세포에 상기 각 유전자에 대한 siRNA를 각각 도입하여, 도입 48시간 후에 상기 각 유전자의 mRNA의 발현을 Taqman PCR에 의해 측정하였다. 이 실험에서는 대조군 RNA(NS)를 도입한 TIG3 세포 혹은 HDF 세포에서의 각 mRNA의 발현을 100%로 하여, 각 siRNA를 도입한 TIG3 세포 혹은 HDF 세포에서의 각 mRNA의 발현을 비교하였다.
그 결과, 도 28~30의 「40nM TIG3 세포에서의 유전자 발현 억제」의 열, 도 31의 HDF 세포에서의 「mRNA 발현」의 열, 혹은 도 32의 HDF 세포에서의 「발현」의 열에 나타내는 바와 같이, 각 siRNA를 도입한 TIG3 세포 혹은 HDF 세포에서는 상기 각 유전자의 mRNA의 발현은, 대조군 RNA(NS)를 도입한 TIG3 세포 혹은 HDF 세포에서의 이들의 mRNA의 발현과 비교하여 현저하게 억제되어 있었다.
〔실시예 13〕TIG3 세포 혹은 HDF 세포의 생존율
상기 11개의 각 유전자의 siRNA를 각각 TIG3 세포 혹은 HDF 세포에 도입하고, 도입 4일 후의 세포 생존율을 MTT 분석에 의해 조사하였다. 그 결과, 도 28~30의 「40nM TIG3 세포에서의 증식 억제」의 열, 도 31의 HDF 세포에서의 「증식 억제」의 열, 혹은 도 32의 HDF 세포의 「증식」의 열에 나타내는 바와 같이, 상기 각 유전자에 대한 siRNA를 도입한 TIG3 세포 혹은 HDF 세포의 생존율은, 당해 siRNA를 도입한 HeLa 세포의 생존율과 비교하여 높고, 현저한 저하는 인정되지 않았다.
상술한 결과로부터, 본 발명의 유전자의 발현을 억제함으로써, 암세포 특이적으로 아포토시스가 유도되는 것이라고 생각된다.
〔실시예 14〕항-단일쇄 DNA 항체를 이용한 게놈 붕괴과정의 해석
슬라이드 유리 상에 HeLa 세포를 파종하고, Pif1, Mms4, Topoisomerase IIIa, Mus81, SIRT1(Sirtuin), Esp1, MPG, Poll, Polm, EndoV의 각 유전자에 대한 siRNA를 트랜스펙션했다. siRNA 도입 약 30시간 후에 세포를 포르말린으로 고정하고, 1차 항체로서 항-ssDNA 항체를 반응시켰다. 항-ssDNA 항체에 대한 형광표식 항체를 2차 항체로서 사용하고, 공초점 레이저 현미경으로 관찰하였다. 그 결과, 도 36에 나타내는 바와 같이, 1개 쇄 DNA를 갖는 핵이 녹색으로 염색되었다.
즉, 상기 각 유전자의 발현을 억제함으로써, 1개 쇄 DNA의 생성을 동반하는 DNA 손상이 생기는 것이 확인되었다.
본 발명의 세포에서의 염색체 안정화를 저해하는 화합물, 혹은, 염색체 안정화에 관여하는 유전자의 기능을 저해하는 화합물은, 암세포 특이적인 아포토시스 유도작용을 갖는다. 당해 화합물을 포함하는 의약 조성물은, 아포토시스 유도작용을 기서로 하는 부작용이 적은 항암제가 되는 것이라고 생각된다. 본 발명에 의해, 염색체 안정화에 관한 유전자를 표적으로 한 아포토시스 유도작용을 기서로 하는 암세포 특이적인 항암제가 처음으로 제공되었다.
어떤 화합물에 대해서 아포토시스 유도작용을 갖는 것을 알 수 있는 경우에서도, 정상세포에 대한 아포토시스 유도작용의 유무가 불명한 화합물은, 의약품으로서 사용하는 것은 어렵다. 당해 화합물이 정상세포에 있어서도 아포토시스 유도작용이 보이는 경우, 부작용의 위험을 동반하기 때문이다. 즉, 아포토시스 유도작 용이 암세포 특이적인 것이 아니면, 실제로 의약품으로서 사용하는 것은 통상 곤란하다. 본 발명의 약제(화합물)는, 아포토시스 유도작용이 암세포 특이적인 점에서, 매우 실용적이고 실효성이 높은 약제라고 할 수 있다.
또한, 염색체 안정화의 저해에 의해, 암세포 특이적으로 아포토시스가 유도되는 메카니즘에 대해서, 본 발명자들에 의해 발견된 지견으로부터 이하와 같이 고찰하는 것이 가능하다.
많은 암세포에서는 암 억제 유전자인 p53에 돌연변이나 결손이 있는 것이 알려져 있고, 또한 DNA 손상 체크 포인트 기구에 이상이 생겨 암화하는 케이스도 알려져 있다. p53이나 DNA 손상 체크 포인트 기구가 이상한 암세포에서는, 기능적인 염색체 안정화 유전자의 발현이 siRNA 등에 의해 억제되어 기능하지 않게 되면, 염색체 안정화 기구가 파탄하여 염색체 DNA에 생긴 손상을 수복할 수 없고, 이러한 세포에서는, 수복되지 않고 남아 있는 DNA 손상이 원인으로 아포토시스가 유도되는 것이라고 생각된다. 한편, 이배체 섬유아세포와 같은 정상세포에서는, 기능적인 염색체 안정화 유전자의 발현이 siRNA 등에 의해 억제되어 기능하지 않게 되면, p53이나 DNA 손상 체크 포인트 기구의 작용에 의해 세포주기가 일시적으로 정지하여, 염색체 DNA에 생긴 손상이 수복되는 것이라고 생각된다.
본 발명은, 암세포 특이적인 아포토시스 유도제를 제공한 것에 덧붙여, 암세포 특이적인 아포토시스 유도의 메카니즘의 해명에서의 매우 유용한 학술적인 지견을 제공하는 것이다.
SEQUENCE LISTING <110> GENECARE RESEARCH INSTITUTE CO.LTD. <120> CARCINOMA CELL-SPECIFIC APOPTOSIS INDUCING AGENT TARGETING GENE RELEVANT TO CHROMOSOME STABILIZATION <130> G3-A0401P <140> PCT/JP2005/006914 <141> 2005-04-08 <150> JP 2004-115404 <151> 2004-04-09 <160> 1063 <170> PatentIn version 3.1 <210> 1 <211> 4535 <212> DNA <213> Homo sapiens <400> 1 gaacgaagaa ggcgtcccgg catcggccaa gattctacat tgctcatctg ggcatctgag 60 cctccttcga agtttcctgt cacaactgtc ctcttgacag catggatgag gaggaagaca 120 atctgtctct gctgaccgca ctgctggaag aaaatgagtc agccttggat tgtaattcag 180 aagaaaataa cttcttgacg cgggaaaatg gcgagcccga cgcatttgat gagctctttg 240 atgccgacgg cgacggtgaa tcttatacag aagaggctga tgatggagaa acaggagaga 300 caagagacga aaaggaaaat ctggccactc tctttggaga tatggaggac ttaacagatg 360 aagaagaagt tcccgcatca cagtcaactg aaaatagggt cctccctgct cctgccccca 420 ggcgagagaa aacgaatgaa gagttgcaag aggaattaag gaatttgcaa gagcaaatga 480 aggccttaca agagcagcta aaagtaacaa caattaaaca gacagcaagc ccagcccgtc 540 tgcaaaaatc ccctgtagag aagtctcccc ggccacctct taaggagagg agagttcaga 600 gaattcagga gtcaacatgc ttttctgcgg agcttgatgt ccctgcgcta ccaagaacca 660 agagggtggc tcgaacacca aaggcttcac ctccagatcc caaaagctca tcttcaagga 720 tgacaagtgc accctcccaa cccctacaga cgatttctcg gaacaaacct agtgggataa 780 ctagaggtca aattgtgggg accccaggaa gttctgggga aacgactcaa cccatctgtg 840 tggaagcctt ctctggtctg cggctcaggc ggcctcgagt atcctccaca gaaatgaaca 900 agaaaatgac cggccgaaaa ctgatcagac tgtctcagat caaggaaaag atggccagag 960 agaagctgga agaaatagat tgggtgacat ttggggttat attgaagaag gttacgccac 1020 agagtgtgaa tagtggaaaa accttcagca tatggaaact gaatgatctt cgtgacctga 1080 cacaatgtgt gtccttgttc ttatttggag aagttcacaa agcgctctgg aagacggagc 1140 aggggactgt cgtagggatc ctcaatgcca accccatgaa gcccaaggat ggttcagagg 1200 aggtgtgttt atctatcgat catcctcaga aggtcttaat tatgggtgaa gctcttgacc 1260 tgggaacctg taaagccaag aagaagaatg gagagccgtg cacgcagact gtgaatttgc 1320 gtgactgtga gtactgtcag taccatgtcc aggctcagta caagaagctc agcgcaaagc 1380 gtgcggatct gcagtccacc ttctctggag gacgaattcc aaagaagttt gcccgcagag 1440 gcaccagcct caaagaacgg ctgtgccaag atggctttta ctacggaggg gtttcttctg 1500 cctcgtatgc agcttcaatt gcagcagctg tggctcctaa gaagaagatt caaaccactc 1560 tgagtaatct ggttgttaag ggcacaaact tgatcatcca ggaaacacgg caaaaactcg 1620 gaatacccca gaagagcctg tcttgctctg aggagttcaa ggaactgatg gacctgccga 1680 cgtgtggagc caggaactta aaacaacatt tagccaaagc cacagcttca gggattatgg 1740 ggagcccaaa accagccatc aagtccatct cggcctcagc actcttgaag caacagaagc 1800 agcggatgtt ggagatgagg agaaggaaat cagaagaaat acagaagcga tttctgcaga 1860 gctcaagtga agttgagagc ccagctgtgc catcttcatc aagacagccc cctgctcagc 1920 ctccacggac aggatccgag ttccccaggc tggagggagc cccggccaca atgacgccca 1980 agctggggcg aggtgtcttg gaaggagatg atgttctctt ttatgatgag tcaccaccac 2040 caagaccaaa actgagtgct ttagcagaag ccaaaaagtt agctgctatc accaaattaa 2100 gggcaaaagg ccaggttctt acaaaaacaa acccaaacag cattaagaag aaacaaaagg 2160 accctcagga catcctggag gtgaaggaac gtgtagaaaa aaacaccatg ttttcttctc 2220 aagctgagga tgaattggag cctgccagga aaaaaaggag agaacaactt gcctatctgg 2280 aatctgagga atttcagaaa atcctaaaag caaaatcaaa acacacaggc atcctgaaag 2340 aggccgaggc tgagatgcag gagcgctact ttgagccact ggtgaaaaaa gaacaaatgg 2400 aagaaaagat gagaaacatc agagaagtga agtgccgtgt cgtgacatgc aagacgtgcg 2460 cctataccca cttcaagctg ctggagacct gcgtcagtga gcagcatgaa taccactggc 2520 atgatggtgt gaagaggttt ttcaaatgtc cctgtggaaa cagaagcatc tccttggaca 2580 gactcccgaa caagcactgc agtaactgtg gcctctacaa atgggaacgg gacggaatgc 2640 taaaggaaaa gactggtcca aagataggag gagaaactct gttaccaaga ggagaagaac 2700 atgctaaatt tctgaacagc cttaaataac ccgaacttca gacattttcc cacagacttc 2760 ctggcctcct gtgactctgg aaagcaaagg attggctgtg tattgtccat tgattcctga 2820 ttgacgccgt caaaaacaaa tgcttgttaa gcccataagc tttgcctgct tactttctgc 2880 cattgggttg gtttgatacc acatttaaca ttgacattta agtggaaaac caagttatca 2940 ttgtcttttc taagctcagt gtggatgatt gcattacttc attcactgaa gtttttgccc 3000 aaaaattgga aggtaaacag agagctatgt ttctgtatct tttggttata gagtgttcac 3060 ttctttatca taacaaaatt ctagtgttta tacgaacacc cagaggcaaa agaatttggc 3120 ttaattctca ctccaggtaa gtagcttaac ttctgggctt cagttttctc atctgtaaaa 3180 tcaggaagat tggactaagt gatcctgaaa tgtatttttt agcactggat ttctacaaat 3240 aataaaactt tcccatctag ataatgatga tcacatagtc ttgatgtacg gacattaaaa 3300 gccagatttc ttcattcaat tctgttatct ctgttttact ctttgaaatt gatcaagcca 3360 ctgaatcact ttgcatttca gtttatatat atagagagaa agaaggtgtc tgctcttaca 3420 ttattgtgga gccctgtgat agaaatatgt aaaatctcat attatttttt ttttaatttt 3480 tttatttttt atgacagggt ctcactatgt caccctggct ggagtgcagt agtgcgatcg 3540 cggcacactg cagccttggc ttccctgggc tcaagcagtc ctcccacctc agtctcccaa 3600 atagctagga ctacaggcgt gcgtgaccaa gcccagctaa tttttgcatt ttttgtagag 3660 atggggtttt gccatgttgc tcaggctggt ctcaaactcc tgagcactag caatccaccc 3720 acctctgttt ccaaaaaaaa aaaaaaaatg aaaggtcaac ccctatgcaa attaccacag 3780 caaaggtttc attcaggaga ttcttccatc tgggcaacct ggttttccaa atatcatttg 3840 acctaagtga atgttgatac tagctaaaga ttgggtaaat tggttgaatt attgtattga 3900 agcttgagct gtagctaaaa gtaatttagg tttcccctaa gatgttatta tgttagggac 3960 ataacacttt tgggaggttg ttgtgggaga tggttgattt aggttttcaa aagctagaaa 4020 taaaatttac atgccttaga tttcataaaa ttctgctcta attgggtgga aggtgctgta 4080 tctaacttgt gttcctccta aggttatgtc ctaataacta ttcttttagg agtatacttc 4140 tactttatag aaggttgctt ttctttttaa ttttttctaa caaagaaaag aataaagtat 4200 ttattaataa gaaccagaaa gcacttgaaa ctgatgtttt taatggctca tttagggtag 4260 atttatttat ctcattaact taaaacagct atgtgtatga aataggtcac aacagaactt 4320 gaacaccagg ttggtgtctg agcaatccct ttcttatggg aaaaacaatg ttcttgtttg 4380 aacagagggt atcattgcag tcagtattca cgtgtatatt gttatataag ttgtataata 4440 tgcttgtaaa ggctgagggt gagctgtatc tggatgcctt tttacaattt gattttaact 4500 tttaaaataa atttaaaaca taaaaaaaaa aaaaa 4535 <210> 2 <211> 4532 <212> DNA <213> Homo sapiens <400> 2 gaacgaagaa ggcgtcccgg catcggccaa gattctacat tgctcatctg ggcatctgag 60 cctccttcga agtttcctgt cacaactgtc ctcttgacag catggatgag gaggaagaca 120 atctgtctct gctgaccgca ctgctggaag aaaatgagtc agccttggat tgtaattcag 180 aagaaaataa cttcttgacg cgggaaaatg gcgagcccga cgcatttgat gagctctttg 240 atgccgacgg cgacggtgaa tcttatacag aagaggctga tgatggagaa acaggagaga 300 caagagacga aaaggaaaat ctggccactc tctttggaga tatggaggac ttaacagatg 360 aagaagaagt tcccgcatca cagtcaactg aaaatagggt cctccctgct cctgccccca 420 ggcgagagaa aacgaatgaa gagttgcaag aggaattaag gaatttgcaa gagcaaatga 480 aggccttaca agagcagcta aaagtaacaa caattaaaca gacagcaagc ccagcccgtc 540 tgcaaaaatc ccctgagaag tctccccggc cacctcttaa ggagaggaga gttcagagaa 600 ttcaggagtc aacatgcttt tctgcggagc ttgatgtccc tgcgctacca agaaccaaga 660 gggtggctcg aacaccaaag gcttcacctc cagatcccaa aagctcatct tcaaggatga 720 caagtgcacc ctcccaaccc ctacagacga tttctcggaa caaacctagt gggataacta 780 gaggtcaaat tgtggggacc ccaggaagtt ctggggaaac gactcaaccc atctgtgtgg 840 aagccttctc tggtctgcgg ctcaggcggc ctcgagtatc ctccacagaa atgaacaaga 900 aaatgaccgg ccgaaaactg atcagactgt ctcagatcaa ggaaaagatg gccagagaga 960 agctggaaga aatagattgg gtgacatttg gggttatatt gaagaaggtt acgccacaga 1020 gtgtgaatag tggaaaaacc ttcagcatat ggaaactgaa tgatcttcgt gacctgacac 1080 aatgtgtgtc cttgttctta tttggagaag ttcacaaagc gctctggaag acggagcagg 1140 ggactgtcgt agggatcctc aatgccaacc ccatgaagcc caaggatggt tcagaggagg 1200 tgtgtttatc tatcgatcat cctcagaagg tcttaattat gggtgaagct cttgacctgg 1260 gaacctgtaa agccaagaag aagaatggag agccgtgcac gcagactgtg aatttgcgtg 1320 actgtgagta ctgtcagtac catgtccagg ctcagtacaa gaagctcagc gcaaagcgtg 1380 cggatctgca gtccaccttc tctggaggac gaattccaaa gaagtttgcc cgcagaggca 1440 ccagcctcaa agaacggctg tgccaagatg gcttttacta cggaggggtt tcttctgcct 1500 cgtatgcagc ttcaattgca gcagctgtgg ctcctaagaa gaagattcaa accactctga 1560 gtaatctggt tgttaagggc acaaacttga tcatccagga aacacggcaa aaactcggaa 1620 taccccagaa gagcctgtct tgctctgagg agttcaagga actgatggac ctgccgacgt 1680 gtggagccag gaacttaaaa caacatttag ccaaagccac agcttcaggg attatgggga 1740 gcccaaaacc agccatcaag tccatctcgg cctcagcact cttgaagcaa cagaagcagc 1800 ggatgttgga gatgaggaga aggaaatcag aagaaataca gaagcgattt ctgcagagct 1860 caagtgaagt tgagagccca gctgtgccat cttcatcaag acagccccct gctcagcctc 1920 cacggacagg atccgagttc cccaggctgg agggagcccc ggccacaatg acgcccaagc 1980 tggggcgagg tgtcttggaa ggagatgatg ttctctttta tgatgagtca ccaccaccaa 2040 gaccaaaact gagtgcttta gcagaagcca aaaagttagc tgctatcacc aaattaaggg 2100 caaaaggcca ggttcttaca aaaacaaacc caaacagcat taagaagaaa caaaaggacc 2160 ctcaggacat cctggaggtg aaggaacgtg tagaaaaaaa caccatgttt tcttctcaag 2220 ctgaggatga attggagcct gccaggaaaa aaaggagaga acaacttgcc tatctggaat 2280 ctgaggaatt tcagaaaatc ctaaaagcaa aatcaaaaca cacaggcatc ctgaaagagg 2340 ccgaggctga gatgcaggag cgctactttg agccactggt gaaaaaagaa caaatggaag 2400 aaaagatgag aaacatcaga gaagtgaagt gccgtgtcgt gacatgcaag acgtgcgcct 2460 atacccactt caagctgctg gagacctgcg tcagtgagca gcatgaatac cactggcatg 2520 atggtgtgaa gaggtttttc aaatgtccct gtggaaacag aagcatctcc ttggacagac 2580 tcccgaacaa gcactgcagt aactgtggcc tctacaaatg ggaacgggac ggaatgctaa 2640 aggaaaagac tggtccaaag ataggaggag aaactctgtt accaagagga gaagaacatg 2700 ctaaatttct gaacagcctt aaataacccg aacttcagac attttcccac agacttcctg 2760 gcctcctgtg actctggaaa gcaaaggatt ggctgtgtat tgtccattga ttcctgattg 2820 acgccgtcaa aaacaaatgc ttgttaagcc cataagcttt gcctgcttac tttctgccat 2880 tgggttggtt tgataccaca tttaacattg acatttaagt ggaaaaccaa gttatcattg 2940 tcttttctaa gctcagtgtg gatgattgca ttacttcatt cactgaagtt tttgcccaaa 3000 aattggaagg taaacagaga gctatgtttc tgtatctttt ggttatagag tgttcacttc 3060 tttatcataa caaaattcta gtgtttatac gaacacccag aggcaaaaga atttggctta 3120 attctcactc caggtaagta gcttaacttc tgggcttcag ttttctcatc tgtaaaatca 3180 ggaagattgg actaagtgat cctgaaatgt attttttagc actggatttc tacaaataat 3240 aaaactttcc catctagata atgatgatca catagtcttg atgtacggac attaaaagcc 3300 agatttcttc attcaattct gttatctctg ttttactctt tgaaattgat caagccactg 3360 aatcactttg catttcagtt tatatatata gagagaaaga aggtgtctgc tcttacatta 3420 ttgtggagcc ctgtgataga aatatgtaaa atctcatatt attttttttt taattttttt 3480 attttttatg acagggtctc actatgtcac cctggctgga gtgcagtagt gcgatcgcgg 3540 cacactgcag ccttggcttc cctgggctca agcagtcctc ccacctcagt ctcccaaata 3600 gctaggacta caggcgtgcg tgaccaagcc cagctaattt ttgcattttt tgtagagatg 3660 gggttttgcc atgttgctca ggctggtctc aaactcctga gcactagcaa tccacccacc 3720 tctgtttcca aaaaaaaaaa aaaaatgaaa ggtcaacccc tatgcaaatt accacagcaa 3780 aggtttcatt caggagattc ttccatctgg gcaacctggt tttccaaata tcatttgacc 3840 taagtgaatg ttgatactag ctaaagattg ggtaaattgg ttgaattatt gtattgaagc 3900 ttgagctgta gctaaaagta atttaggttt cccctaagat gttattatgt tagggacata 3960 acacttttgg gaggttgttg tgggagatgg ttgatttagg ttttcaaaag ctagaaataa 4020 aatttacatg ccttagattt cataaaattc tgctctaatt gggtggaagg tgctgtatct 4080 aacttgtgtt cctcctaagg ttatgtccta ataactattc ttttaggagt atacttctac 4140 tttatagaag gttgcttttc tttttaattt tttctaacaa agaaaagaat aaagtattta 4200 ttaataagaa ccagaaagca cttgaaactg atgtttttaa tggctcattt agggtagatt 4260 tatttatctc attaacttaa aacagctatg tgtatgaaat aggtcacaac agaacttgaa 4320 caccaggttg gtgtctgagc aatccctttc ttatgggaaa aacaatgttc ttgtttgaac 4380 agagggtatc attgcagtca gtattcacgt gtatattgtt atataagttg tataatatgc 4440 ttgtaaaggc tgagggtgag ctgtatctgg atgccttttt acaatttgat tttaactttt 4500 aaaataaatt taaaacataa aaaaaaaaaa aa 4532 <210> 3 <211> 3721 <212> DNA <213> Homo sapiens <400> 3 agaaggcgtc ccggcatcgg ccaagattct acattgctca tctgggcatc tgagcctcct 60 tcgaagtttc ctgtcacaac tgtcctcttg acagcatgga tgaggaggaa gacaatctgt 120 ctctgctgac cgcactgctg gaagaaaatg agtcagcctt ggattgtaat tcagaagaaa 180 ataacttctt gacgcgggaa aatggcgagc ccgacgcatt tgatgagctc tttgatgccg 240 acggcgacgg tgaatcttat acagaagagg ctgatgatgg agaaacagga gagacaagag 300 acgaaaagga aaatctggcc actctctttg gagatatgga ggacttaaca gatgaagaag 360 aagttcccgc atcacagtca actgaaaata gggtcctccc tgctcctgcc cccaggcgag 420 agaaaacgaa tgaagagttg caagaggaat taaggaattt gcaagagcaa atgaaggcct 480 tacaagagca gctaaaagta acaacaatta aacagacagc aagcccagcc cgtctgcaaa 540 aatcccctga gaagtctccc cggccacctc ttaaggagag gagagttcag agaattcagg 600 agtcaacatg cttttctgcg gagcttgatg tccctgcgct accaagaacc aagagggtgg 660 ctcgaacacc aaaggcttca cctccagatc ccaaaagctc atcttcaagg atgacaagtg 720 caccctccca acccctacag acgatttctc ggaacaaacc tagtgggata actagaggtc 780 aaattgtggg gaccccagga agttctgggg aaacgactca acccatctgt gtggaagcct 840 tctctggtct gcggctcagg cggcctcgag tatcctccac agaaatgaac aagaaaatga 900 ccggccgaaa actgatcaga ctgtctcaga tcaaggaaaa gatggccaga gagaagctgg 960 aagaaataga ttgggtgaca tttggggtta tattgaagaa ggttacgcca cagagtgtga 1020 atagtggaaa aaccttcagc atatggaaac tgaatgatct tcgtgacctg acacaatgtg 1080 tgtccttgtt cttatttgga gaagttcaca aagcgctctg gaagacggag caggggactg 1140 tcgtagggat cctcaatgcc aaccccatga agcccaagga tggttcagag gaggtgtgtt 1200 tatctatcga tcatcctcag aaggtcttaa ttatgggtga agctcttgac ctgggaacct 1260 gtaaagccaa gaagaagaat ggagagccgt gcacgcagac tgtgaatttg cgtgactgtg 1320 agtactgtca gtaccatgtc caggctcagt acaagaagct cagcgcaaag cgtgcggatc 1380 tgcagtccac cttctctgga ggacgaattc caaagaagtt tgcccgcaga ggcaccagcc 1440 tcaaagaacg gctgtgccaa gatggctttt actacggagg ggtttcttct gcctcgtatg 1500 cagcttcaat tgcagcagct gtggctccta agaagaagat tcaaaccact ctgagtaatc 1560 tggttgttaa gggcacaaac ttgatcatcc aggaaacacg gcaaaaactc ggaatacccc 1620 agaagagcct gtcttgctct gaggagttca aggaactgat ggacctgccg acgtgtggag 1680 ccaggaactt aaaacaacat ttagccaaag ccacagcttc agggattatg gggagcccaa 1740 aaccagccat caagtccatc tcggcctcag cactcttgaa gcaacagaag cagcggatgt 1800 tggagatgag gagaaggaaa tcagaagaaa tacagaagcg atttctgcag agctcaagtg 1860 aagttgagag cccagctgtg ccatcttcat caagacagcc ccctgctcag cctccacgga 1920 caggatccga gttccccagg ctggagggag ccccggccac aatgacgccc aagctggggc 1980 gaggtgtctt ggaaggagat gatgttctct tttatgatga gtcaccacca ccaagaccaa 2040 aactgagtgc tttagcagaa gccaaaaagt tagctgctat caccaaatta agggcaaaag 2100 gccaggttct tacaaaaaca aacccaaaca gcattaagaa gaaacaaaag gaccctcagg 2160 acatcctgga ggtgaaggaa cgtgtagaaa aaaacaccat gttttcttct caagctgagg 2220 atgaattgga gcctgccagg aaaaaaagga gagaacaact tgcctatctg gaatctgagg 2280 aatttcagaa aatcctaaaa gcaaaatcaa aacacacagg catcctgaaa gaggccgagg 2340 ctgagatgca ggagcgctac tttgagccac tggtgaaaaa agaacaaatg gaagaaaaga 2400 tgagaaacat cagagaagtg aagtgccgtg tcgtgacatg caagacgtgc gcctataccc 2460 acttcaagct gctggagacc tgcgtcagtg agcagcatga ataccactgg catgatggtg 2520 tgaagaggtt tttcaaatgt ccctgtggaa acagaagcat ctccttggac agactcccga 2580 acaagcactg cagtaactgt ggcctctaca aatgggaacg ggacggaatg ctaaaggaaa 2640 agactggtcc aaagatagga ggagaaactc tgttaccaag aggagaagaa catgctaaat 2700 ttctgaacag ccttaaataa cccgaacttc agacattttc ccacagactt cctggcctcc 2760 tgtgactctg gaaagcaaag gattggctgt gtattgtcca ttgattcctg attgacgccg 2820 tcaaaaacaa atgcttgtta agcccataag ctttgcctgc ttactttctg ccattgggtt 2880 ggtttgatac cacatttaac attgacattt aagtggaaaa ccaagttatc attgtctttt 2940 ctaagctcag tgtggatgat tgcattactt cattcactga agtttttgcc caaaaattgg 3000 aaggtaaaca gagagctatg tttctgtatc ttttggttat agagtgttca cttctttatc 3060 ataacaaaat tctagtgttt atacgaacac ccagaggcaa aagaatttgg cttaattctc 3120 actccaggta agtagcttaa cttctgggct tcagttttct catctgtaaa atcaggaaga 3180 ttggactaag tgatcctgaa atgtattttt tagcactgga tttctacaaa taataaaact 3240 ttcccatcta gataatgatg atcacatagt cttgatgtac ggacattaaa agccagattt 3300 cttcattcaa ttctgttatc tctgttttac tctttgaaat tgatcaagcc actgaatcac 3360 tttgcatttc agtttatata tatagagaga aagaaggtgt ctgctcttac attattgtgg 3420 agccctgtga tagaaatatg taaaatctca tattattttt tttttaattt ttttattttt 3480 tatgacaggg tctcactatg tcaccctggc tggagtgcag tagtgcgatc gcggcacact 3540 gcagccttgg cttccctggg ctcaagcagt cctcccacct cagtctccca aatagctagg 3600 actacaggcg tgcgtgacca agcccagcta atttttgcat tttttgtaga gatggggttt 3660 tgccatgttg ctcaggctgg tctcaaactc ctgagcacta gcaatccacc cacctctgtt 3720 t 3721 <210> 4 <211> 4619 <212> DNA <213> Homo sapiens <400> 4 gaaggcgtcc cggcatcggc caagattcta cattgctcat ctgggcatct gagcctcctt 60 cgaagtttcc tgtcacaact gtcctcttga cagcatggat gaggaggaag acaatctgtc 120 tctgctgacc gcactgctgg aagaaaatga gtcagccttg gattgtaatt cagaagaaaa 180 taacttcttg acgcgggaaa atggcgagcc cgacgcattt gatgagctct ttgatgccga 240 cggcgacggt gaatcttata cagaagaggc tgatgatgga gaaacaggag agacaagaga 300 cgaaaaggaa aatctggcca ctctctttgg agatatggag gacttaacag atgaagaaga 360 agttcccgca tcacagtcaa ctgaaaatag ggtcctccct gctcctgccc ccaggcgaga 420 gaaaacgaat gaagagttgc aagaggaatt aaggaatttg caagagcaaa tgaaggcctt 480 acaagagcag ctaaaagtaa caacaattaa acagacagca agcccagccc gtctgcaaaa 540 atcccctgag aagtctcccc ggccacctct taaggagagg agagttcaga gaattcagga 600 gtcaacatgc ttttctgcgg agcttgatgt ccctgcgcta ccaagaacca agagggtggc 660 tcgaacacca aagccttcac ctccagatcc caaaagctca tcttcaagga tgacaagtgc 720 accctcccaa cccctacaga cgatttctcg gaacaaacct agtgggataa ctagaggtca 780 aattgtgggg accccaggaa gttctgggga aacgactcaa cccatctgtg tggaagcctt 840 ctctggtctg cggctcaggc ggcctcgagt atcctccaca gaaatgaaca agaaaatgac 900 cggccgaaaa ctgatcagac tgtctcagat caaggaaaag atggccagag agaagctgga 960 agaaatagat tgggtgacat ttggggttat attgaagaag gttacgccac agagtgtgaa 1020 tagtggaaaa accttcagca tatggaaact gaatgatctt cgtgacctga cacaatgtgt 1080 gtccttgttc ttatttggag aagttcacaa agcgctctgg aagacggagc aggggactgt 1140 cgtagggatc ctcaatgcca accccatgaa gcccaaggat ggttcagagg aggtgtgttt 1200 atctatcgat catcctcaga aggtcttaat tatgggtgaa gctcttgacc tgggaacctg 1260 taaagccaag aagaagaatg gagagccgtg cacgcagact gtgaatttgc gtgactgtga 1320 gtactgtcag taccatgtcc aggctcagta caagaagctc agtgcaaagc gtgcggatct 1380 gcagtccacc ttctctggag gacgaattcc aaagaagttt gcccgcagag gcaccagcct 1440 caaagaacgg ctgtgccaag atggctttta ctacggaggg gtttcttctg cctcgtatgc 1500 agcttcaatt gcagcagctg tggctcctaa gaagaagatt caaaccactc tgagtaatct 1560 ggttgttaag ggcacaaact tgatcatcca ggaaacacgg caaaaactcg gaatacccca 1620 gaagagcctg tcttgctctg aggagttcaa ggaactgatg gacctgccga cgtgtggagc 1680 caggaactta aaacaacatt tagccaaagc ctcagcttca gggattatgg ggagcccaaa 1740 accagccatc aagtccatct cggcctcagc actcttgaag caacagaagc agcggatgtt 1800 ggagatgagg agaaggaaat cagaagaaat acagaagcga tttctgcaga gctcaagtga 1860 agttgagagc ccagctgtgc catcttcatc aagacagccc cctgctcagc ctccacggac 1920 aggatccgag ttccccaggc tggagggagc cccggccaca atgacgccca agctggggcg 1980 aggtgtcttg gaaggagatg atgttctctt ttatgatgag tcaccaccac caagaccaaa 2040 actgagtgct ttagcagaag ccaaaaagtt agctgctatc accaaattaa gggcaaaagg 2100 ccaggttctt acaaaaacaa acccaaacag cattaagaag aaacaaaagg accctcagga 2160 catcctggag gtgaaggaac gtgtagaaaa aaacaccatg ttttcttctc aagctgagga 2220 tgaattggag cctgccagga aaaaaaggag agaacaactt gcctatctgg aatctgagga 2280 atttcagaaa atcctaaaag caaaatcaaa acacacaggc atcctgaaag aggccgaggc 2340 tgagatgcag gagcgctact ttgagccact ggtgaaaaaa gaacaaatgg aagaaaagat 2400 gagaaacatc agagaagtga agtgccgtgt cgtgacatgc aagacgtgcg cctataccca 2460 cttcaagctg ctggagacct gcgtcagtga gcagcatgaa taccactggc atgatggtgt 2520 gaagaggttt ttcaaatgtc cctgtggaaa cagaagcatc tccttggaca gactcccgaa 2580 caagcactgc agtaactgtg gcctctacaa atgggaacgg gacggaatgc taaaggtatg 2640 ccatttgcgt actaattttt gactcctttt agtgacccat gctaataatg tggaaccatc 2700 tcctattaaa atattttcat ttttctagga aaagactggt ccaaagatag gaggagaaac 2760 tctgttacca agaggagaag aacatgctaa atttctgaac agccttaaat aacccgaact 2820 tcagacattt tcccacagac ttcctggcct cctgtgactc tggaaagcaa aggattggct 2880 gtgtattgtc cattgattcc tgattgacgc cgtcaaaaac aaatgcttgt taagcccata 2940 agctttgcct gcttactttc tgccattggg ttggtttgat accacattta acattgacat 3000 ttaagtggaa aaccaagtta tcattgtctt ttctaagctc agtgtggatg attgcattac 3060 ttcattcact gaagtttttg cccaaaaatt ggaaggtaaa cagagagcta tgtttctgta 3120 tcttttggtt atagagtgtt cacttcttta tcataacaaa attctagtgt ttatacgaac 3180 acccagaggc aaaagaattt ggcttaattc tcactccagg taagtagctt aacttctggg 3240 cttcagtttt ctcatctgta aaatcaggaa gattggacta agtgatcctg aaatgtattt 3300 tttagcactg gatttctaca aataataaaa ctttcccatc tagataatga tgatcacata 3360 gtcttgatgt acggacatta aaagccagat ttcttcattc aattctgtta tctctgtttt 3420 actctttgaa attgatcaag ccactgaatc actttgcatt tcagtttata tatagagaga 3480 gaaagaaggc tgtctgctct tacattattg tggagccctg tgatagaaat atgtaaaatc 3540 tcatattatt ttttttttaa tttttttatt ttttatgaca gggtctcact atgtcaccct 3600 ggctggagtg cagtagtgcg atcgcggcac actgcagcct tggcttccct gggctcaagc 3660 agtcctccca cctcagtctc ccaaatagct aggactacag gcgtgcgtga ccaagcccag 3720 ctaatttttg cattttttgt agagatgggg ttttgccatg ttgctcaggc tggtctcaaa 3780 ctcctgagca ctagcaatcc acccacctct gtttccaaaa aaaaaaaaaa aatgaaaggt 3840 caacccctat gcaaattacc acagcaaagg tttcattcag gagattcttc catctgggca 3900 acctggtttt ccaaatatca tttgacctaa gtgaatgttg atactagcta aagattgggt 3960 aaattggttg aattattgta ttgaagcttg agctgtagct aaaagtaatt taggtttccc 4020 ctaagatgtt attatgttag ggacataaca cttttgggag gttgttgtgg gagatggttg 4080 atttaggttt tcaaaagcta gaaataaaat ttacatgcct tagatttcat aaaattctgc 4140 tctaattggg tggaaggtgc tgtatctaac ttgtgttcct cctaaggtta tgtcctaata 4200 actattcttt taggagtata cttctacttt atagaaggtt gcttttcttt ttaatttttt 4260 ctaacaaaga aaagaataaa gtatttatta ataagaacca gaaagcactt gaaactgatg 4320 tttttaatgg ctcatttagg gtagatttat ttatctcatt aacttaaaac agctatgtgt 4380 atgaaatagg tcacaacaga acttgaacac caggttggtg tctgagcaat ccctttctta 4440 tgggaaaaac aatgttcttg tttgaacaga gggtatcatt gcagtcagta ttcacgtgta 4500 tattgttata taagttgtat aatatgcttg taaaggctga gggtgagctg tatctggatg 4560 cctttttaca atttgatttt aacttttaaa ataaatttaa aacataaaaa aaaaaaaaa 4619 <210> 5 <211> 2141 <212> DNA <213> Homo sapiens <400> 5 gaacgaagaa ggcgtcccgg catcggccaa gattctacat tgctcatctg ggcatctgag 60 cctccttcga agtttcctgt cacaactgtc ctcttgacag catggatgag gaggaagaca 120 atctgtctct gctgaccgca ctgctggaag aaaatgagtc agccttggat tgtaattcag 180 aagaaaataa cttcttgacg cgggaaaatg gcgagcccga cgcatttgat gagctctttg 240 atgccgacgg cgacggtgaa tcttatacag aagaggctga tgatggagaa acaggagaga 300 caagagacga aaaggaaaat ctggccactc tctttggaga tatggaggac ttaacagatg 360 aagaagaagt tcccgcatca cagtcaactg aaaatagggt cctccctgct cctgccccca 420 ggcgagagaa aacgaatgaa gagttgcaag aggaattaag gaatttgcaa gagcaaatga 480 aggccttaca agagcagcta aaagtaacaa caattaaaca gacagcaagc ccagcccgtc 540 tgcaaaaatc ccctgtagag aagtctcccc ggccacctct taaggagagg agagttcaga 600 gaattcagga gtcaacatgc ttttctgcgg agcttgatgt ccctgcgcta ccaagaacca 660 agagggtggc tcgaacacca aagccttcac ctccagatcc caaaagctca tcttcaagga 720 tgacaagtgc accctcccaa cccctacaga cgatttctcg gaacaaacct agtgggataa 780 ctagaggtca aattgtgggg accccaggaa gttctgggga aacgactcaa cccatctgtg 840 tggaagcctt ctctggtctg cggctcaggc ggcctcgagt atcctccaca gaaatgaaca 900 agaaaatgac cggccgaaaa ctgatcagac tgtctcagat caaggaaaag atggccagag 960 agaagctgga agaaatagat tgggtgacat ttggggttat attgaagagg gttacgccac 1020 agagtgtgaa tagtggaaaa accttcagca tatggaaact gaatgatctt cgtgacctga 1080 cacaatgtgt gtccttgttc ttatttggag aagttcacaa agcgctctgg aagacggagc 1140 aggggactgt cgtagggatc ctcaatgcca accccatgaa gcccaaggat ggttcagagg 1200 aggtgtgttt atctatcgat catcctcaga aggtcttaat tatgggtgaa gctcttgacc 1260 tgggaacctg taaagccaag aagaagaatg gagagccgtg cacgcagact gtgaatttgc 1320 gtgactgtga gtactgtcag taccatgtcc aggctcagta caagaagctc agcgcaaagc 1380 gtgcggatct gcagtccacc ttctctggag gacgaattcc aaagaagttt gcccgcagag 1440 gcaccagcct caaagaacgg ctgtgccaag atggctttta ctacggaggg gtttcttctg 1500 cctcgtatgc agcttcaatt gcagcagctg tggctcctaa gaagaagatt caaaccactc 1560 tgagtaatct ggttgttaag ggcacaaact tgatcatcca ggaaacacgg caaaaactcg 1620 gaatacccca gaagagcctg tcttgctctg aggagttcaa ggaactgatg gacctgccga 1680 cgtgtggagc caggaactta aaacaacatt tagccaaagc cacagcttca gggattatgg 1740 ggagcccaaa accagccatc aagtccatct cggcctcagc actcttgaag caacagaagc 1800 agcggatgtt ggagatgagg agaaggaaat cagaagaaat acagaagcga tttctgcaga 1860 gctcaagtga agttgagagc ccagctgtgc catcttcatc aagacagccc cctgctcagc 1920 ctccacggac aggatccgag ttccccaggc tggagggagc cccggccaca atgacgccca 1980 agctggggcg aggtgtcttg gaaggagatg atgttctctt ttatgatgag tcaccaccac 2040 caagaccaaa actgagtgct ttagcagaag ccaaaaagtt agctgctatc accaaattaa 2100 gggcaaaagg ccaggttctt acaaaaacaa acccaaacag c 2141 <210> 6 <211> 2989 <212> DNA <213> Homo sapiens <400> 6 cggaacaaac ctagtgggat aactagaggt caaattgtgg ggaccccagg aagttctggg 60 gaaacgactc aacccatctg tgtggaagcc ttctctggtc tgcggctcag gcggcctaga 120 gtatcctcca cagaaatgaa caagaaaatg accggccgaa aactgatcag actgtctcag 180 atcaaggaaa agatggccag agagaagctg gaagaaatag attgggtgac atttggggtt 240 atattgaaga aggttacgcc acagagtgtg aatagtggaa aaaccttcag catatggaaa 300 ctgaatgatc ttcgtgacct gacacaatgt gtgtccttgt tcttatttgg agaagttcac 360 aaagcgctct ggaagacgga gcaggggact gtcgtaggga tcctcaatgc caaccccatg 420 aagcccaagg atggttcaga ggaggtgtgt ttatctatcg atcatcctca gaaggtctta 480 attatgggtg aagctcttga cctgggaacc tgtaaagcca agaagaagaa tggagagccg 540 tgcacgcaga ctgtgaattt gcgcgactgt gagtactgtc agtaccatgt ccaggctcag 600 tacaagaagc tcagtgcaaa gcgtgcggat ctgcagtcca ccttctctgg aggacgaatt 660 ccaaagaagt ttgcccgcag aggcaccagc ctcaaagaac ggctgtgcca agatggcttt 720 tactacggag gggtttcttc tgcctcgtat gcagcttcaa ttgcagcagc tgtggctcct 780 aagaagaaga ttcaaaccac tctgagtaat ctggttgtta agggcacaaa cttgatcatc 840 caggaaacac ggcaaaaact cggaataccc cagaagagcc tgtcttgctc tgaggagttc 900 aaggaactga tggacctgcc gacgtgtgga gccaggaact taaaacaaca tttagccaaa 960 gcctcagctt cagggattat ggggagccca aaaccagcca tcaagtccat ctcggcctca 1020 gcactcttga agcaacagaa gcagcggatg ttggagatga ggagaaggaa atcagaagaa 1080 atacagaagc gatttctgca gagctcaagt gaagttgaga gcccagctgt gccatcttca 1140 tcaagacagc cccctgctca gcctccacgg acaggatccg agttccccag gctggaggga 1200 gccccggcca caatgacgcc caagctgggg cgaggtgtct tggaaggaga tgatgttctc 1260 ttttatgatg agtcaccacc accaagacca aaactgagtg ctttagcaga agccaaaaag 1320 ttagctgcta tcaccaaatt aagggcaaaa ggccaggttc ttacaaaaac aaacccaaac 1380 agcattaaga agaaacaaaa ggaccctcag gacatcctgg aggtgaagga acgtgtagaa 1440 aaaaacacca tgttttcttc tcaagctgag gatgaattgg agcctgccag gaaaaaaagg 1500 agagaacaac ttgcctatct ggaatctgag gaatttcaga aaatcctaaa agcaaaatca 1560 aaacacacag gcatcctgaa agaggccgag gctgagatgc aggagcgcta ctttgagcca 1620 ctggtgaaaa aagaacaaat ggaagaaaag atgagaaaca tcagagaagt gaagtgccgt 1680 gtcgtgacat gcaagacgtg cgcctatacc cacttcaagc tgctggagac ctgcgtcagt 1740 gagcagcatg aataccactg gcatgatggt gtgaagaggt ttttcaaatg tccctgtgga 1800 aacagaagca tctccttgga cagactcccg aacaagcact gcagtaactg tggcctctac 1860 aaatgggaac gggacggaat gctaaaggaa aagactggtc caaagatagg aggagaaact 1920 ctgttaccaa gaggagaaga acatgctaaa tttctgaaca gccttaaata acccgaactt 1980 cagacatttt cccacagact tcctggcctc ctgtgactct ggaaagcaaa ggattggctg 2040 tgtattgtcc attgattcct gattgacgcc gtcaaaaaca aatgcttgtt aagcccataa 2100 gctttgcctg cttactttct gccattgggt tggtttgata ccacatttaa cattgacatt 2160 taagtggaaa accaagttat cattgtcttt tctaagctca gtgtggatga ttgcattact 2220 tcattcactg aagtttttgc ccaaaaattg gaaggtaaac agagagctat gtttctgtat 2280 cttttggtta tagagtgttc acttctttat cataacaaaa ttctagtgtt tatacgaaca 2340 cccagaggca aaagaatttg gcttaattct cactccaggt aagtagctta acttctgggc 2400 ttcagttttc tcatctgtaa aatcaggaag attggactaa gtgatcctga aatgtatttt 2460 ttagcactgg atttctacaa ataataaaac tttcccatct agataatgat gatcacatag 2520 tcttgatgta cggacattaa aagccagatt tcttcattca attctgttat cgctgtttta 2580 ctctttgaaa ttgatcaagc cactgaatca ctttgcattt cagtttatat atagagagag 2640 aaagaaggct gtctgctctt acattattgt ggagccctgt gatagaaata tgtaaaatct 2700 catattattt tttttttaat ttttttattt tttatgacag ggtctcacta tgtcaccctg 2760 gctggagtgc agtagtgcga tcgcggcaca ctgcagcctt ggcttccctg ggctcaagca 2820 gtcctcccac ctcagtctcc caaatagcta ggactacagg cgtgcgtgac caagcccagc 2880 taatttttgc attttttgta gagatggggt tttgccatgt tgctcaggct ggtctcaaac 2940 tcctgagcac tagcaatcca cccacctctg tttccaaaaa aaaaaaaaa 2989 <210> 7 <211> 2312 <212> DNA <213> Homo sapiens <400> 7 ggcacgaggc tgaatgatct tcgtgacctg acacaatgtg tgtccttgtt cttatttgga 60 gaagttcaca aagcgctctg gaagacggag caggggactg tcgtagggat cctcaatgcc 120 aaccccatga agcccaagga tggttcagag gaggtgtgtt tatctatcga tcatcctcag 180 aaggtcttaa ttatgggtga agctcttgac ctgggaacct gtaaagccaa gaagaagaat 240 ggagagccgt gcacgcagac tgtgaatttg cgtgactgtg agtactgtca gtaccatgtc 300 caggctcagt acaagaagct cagcgcaaag cgtgcggatt tgcagtccac cttctctgga 360 ggacgaattc caaagaagtt tgcccgcaga ggcaccagcc tcaaagaacg gctgtgccaa 420 gatggctttt actacggagg ggtttcttct gcctcgtatg cagcttcaat tgcagcagct 480 gtggctccta agaagaagat tcaaaccact ctgagtaatc tggttgttaa gggcacaaac 540 ttgatcatcc aggaaacacg gcaaaaactc ggaatacccc agaagagcct gtcttgctct 600 gaggagttca aggaactgat ggacctgccg acgtgtggag ccaggaactt aaaacaacat 660 ttagccaaag ccacagcttc agggattatg gggagcccaa aaccagccat caagtccatc 720 tcggcctcag cactcttgaa gcaacagaag cagcggatgt tggagatgag gagaaggaaa 780 tcagaagaaa tacagaagcg atttctgcag agctcaagtg aagttgagag cccagctgtg 840 ccatcttcat caagacagcc ccctgctcag cctccacgga caggatccga gttccccagg 900 ctggagggag ccccggccac aatgacgccc aagctggggc gaggtgtctt ggaaggagat 960 gatgttctct tttatgatga gtcaccacca ccaagaccaa aactgagtgc tttagcagaa 1020 gccaaaaagt tagctgctat caccaaatta agggcaaaag gccaggttct tacaaaaaca 1080 aacccaaaca gcattaagaa gaaacaaaag gaccctcagg acatcctgga ggtgaaggaa 1140 cgtgtagaaa aaaacaccat gttttcttct caagctgagg atgaattgga gcctgccagg 1200 aaaaaaagga gagaacaact tgcctatctg gaatctgagg aatttcagaa aatcctaaaa 1260 gcaaaatcaa aacacacagg catcctgaaa gaggccgagg ctgagatgca ggagcgctac 1320 tttgagccac tggtgaaaaa agaacaaatg gaagaaaaga tgagaaacat cagagaagtg 1380 aagtgccgtg tcgtgacatg caagacgtgc gcctataccc acttcaagct gctggagacc 1440 tgcgtcagtg agcagcatga ataccactgg catgatggtg tgaagaggtt tttcaaatgt 1500 ccctgtggaa acagaagcat ctccttggac agactcccga acaagcactg cagtaactgt 1560 ggcctctaca aatgggaacg ggacggaatg ctaaaggaaa agactggtcc aaagatagga 1620 ggagaaactc tgttaccaag aggagaagaa catgctaaat ttctgaacag ccttaaataa 1680 cccgaacttc agacattttc ccacagactt cctggcctcc tgtgactctg gaaagcaaag 1740 gattggctgt gtattgtcca ttgattcctg attgacgccg tcaaaaacaa atgcttgtta 1800 agcccataag ctttgcctgc ttactttctg ccattgggtt ggtttgatac cacatttaac 1860 attgacattt aagtggaaaa ccaagttatc attgtctttt ctaagctcag tgtggatgat 1920 tgcattactt cattcactga agtttttgcc caaaaattgg aaggtaaaca gagagctatg 1980 tttctgtatc ttttggttat agagtgttca cttctttatc ataacaaaat tctagtgttt 2040 atacgaacac ccagaggcaa aagaatttgg cttaattctc actccaggta agtagcttaa 2100 cttctgggct tcagttttct catctgtaaa atcaggaaga ttggactaag tgatcctgaa 2160 atgtattttt tagcactgga tttctacaaa taataaaact ttcccatcta gataatgatg 2220 atcacatagt cttgatgtac ggacattaaa agccagattt cttcattcaa aaaaaaaaaa 2280 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa 2312 <210> 8 <211> 1658 <212> DNA <213> Homo sapiens <400> 8 gaattcccac ctgaggagtt caaggaactg atggacctgc cgacgtgtgg agccaggaac 60 ttaaaacaac atttagccaa agccacagct tcagggatta tggggagccc aaaaccagcc 120 atcaagtcca tctcggcctc agcactcttg aagcaacaga agcagcggat gttggagatg 180 aggagaagga aatcagaaga aatacagaag cgatttctgc agagctcaag tgaagttgag 240 agcccagctg tgccatcttc atcaagacag ccccctgctc agcctccacg gacaggatcc 300 gagttcccca ggctggaggg agccccggcc acaatgacgc ccaagctggg gcgaggtgtc 360 ttggaaggag atgatgttct cttttatgat gagtcaccac caccaagacc aaaactgagt 420 gctttagcag aagccaaaaa gttagctgct atcaccaaat taagggcaaa aggccaggtt 480 cttacaaaaa caaacccaaa cagcattaag aagaaacaaa aggaccctca ggacatcctg 540 gaggtgaagg aacgtgtaga aaaaaacacc atgttttctt ctcaagctga ggatgaattg 600 gagcctgcca ggaaaaaaag gagagaacaa cttgcctatc tggaatctga ggaatttcag 660 aaaatcctaa aagcaaaatc aaaacacaca ggcatcctga aagaggccga ggctgagatg 720 caggagcgct actttgagcc actggtgaaa aaagaacaaa tggaagaaaa gatgagaaac 780 atcagagaag tgaagtgccg tgtcgtgaca tgcaagacgt gcgcctatac ccacttcaag 840 ctgctggaga cctgcgtcag tgagcagcat gaataccact ggcatgatgg tgtgaagagg 900 tttttcaaat gtccctgtgg aaacagaagc atctccttgg acagactccc gaacaagcac 960 tgcagtaact gtggcctcta caaatgggaa cgggacggaa tgctaaagga aaagactggt 1020 ccaaagatag gaggagaaac tctgttacca agaggagaag aacatgctaa atttctgaac 1080 agccttaaat aacccgaact tcagacattt tcccacagac ttcctggcct cctgtgactc 1140 tggaaagcaa aggattggct gtgtattgtc cattgattcc tgattgacgc cgtcaaaaac 1200 aaatgcttgt taagcccata agctttgcct gcttactttc tgccattggg ttggtttgat 1260 accacattta acattgacat ttaagtggaa aaccaagtta tcattgtctt ttctaagctc 1320 agtgtggatg attgcattac ttcattcact gaagtttttg cccaaaaatt ggaaggtaaa 1380 cagagagcta tgtttctgta tcttttggtt atagagtgtt cacttcttta tcataacaaa 1440 attctagtgt ttatacgaac acccagaggc aaaagaattt ggcttaattc tcactccagg 1500 taagtagctt aacttctggg cttcagtttt ctcatctgta aaatcaggaa gattggacta 1560 agtgatcctg aaatgtattt tttagcactg gatttctaca aataataaaa ctttcccatc 1620 taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa 1658 <210> 9 <211> 3180 <212> DNA <213> Homo sapiens <400> 9 cggggccacg ccgattggcg cgaagttttc ttttctcctt ccaccttctt ttcatttcta 60 gtgagacaca cgctttggtc ctggctttcg gcccgtagtt gtagaaggag ccctgctggt 120 gcaggttaga ggtgccgcat cccccggagc tctcgaagtg gaggcggtag gaaacggagg 180 gcttgcggct agccggagga agctttggag ccggaagcca tggcacacta ccccacaagg 240 ctgaagacca gaaaaactta ttcatgggtt ggcaggccct tgttggatcg aaaactgcac 300 taccaaacct atagagaaat gtgtgtgaaa acagaaggtt gttccaccga gattcacatc 360 cagattggac agtttgtgtt gattgaaggg gatgatgatg aaaacccgta tgttgctaaa 420 ttgcttgagt tgttcgaaga tgactctgat cctcctccta agaaacgtgc tcgagtacag 480 tggtttgtcc gattctgtga agtccctgcc tgtaaacggc atttgttggg ccggaagcct 540 ggtgcacagg aaatattctg gtatgattac ccggcctgtg acagcaacat taatgcggag 600 accatcattg gccttgttcg ggtgatacct ttagccccaa aggatgtggt accgacgaat 660 ctgaaaaatg agaagacact ctttgtgaaa ctatcctgga atgagaagaa attcaggcca 720 ctttcctcag aactatttgc ggagttgaat aaaccacaag agagtgcagc caagtgccag 780 aaacccgtga gagccaagag taagagtgca gagagccctt cttggacccc agcagaacat 840 gtggccaaaa ggattgaatc aaggcactcc gcctccaaat ctcgccaaac tcctacccat 900 cctcttaccc caagagccag aaagaggctg gagcttggca acttaggtaa ccctcagatg 960 tcccagcaga cttcatgtgc ctccttggat tctccaggaa gaataaaacg gaaagtggcc 1020 ttctcggaga tcacctcacc ttctaagaga tctcagcctg ataaacttca aaccttgtct 1080 ccagctctga aagccccaga gaaaaccaga gagactggac tctcttatac tgaggatgac 1140 aagaaggctt cacctgaaca tcgcataatc ctgagaaccc gaattgcagc ttcgaaaacc 1200 atagacatta gagaggagag aacacttacc cctatcagtg ggggacagag atcttcagtg 1260 gtgccatccg tgattctgaa accagaaaac atcaaaaaga gggatgcaaa agaagcaaaa 1320 gcccagaatg aagcgacctc tactccccat cgtatccgca gaaagagttc tgtcttgact 1380 atgaatcgga ttaggcagca gcttcggttt ctaggtaata gtaaaagtga ccaagaagag 1440 aaagagattc tgccagcagc agagatttca gactctagca gtgacgaaga agaggcttcc 1500 acaccgcccc ttccaaggag agcacccaga actgtgtcca ggaacctgcg atcttccttg 1560 aagtcatcct tacataccct cacgaaggtg ccaaagaaga gtctcaagcc tagaacgcca 1620 cgttgtgccg ctcctcagat ccgtagtcga agcctggctg cccaggagcc agccagtgtg 1680 ctggaggaag cccgactgag gctgcatgtt tctgctgtac ctgagtctct tccctgtcgg 1740 gaacaggaat tccaagacat ctacaatttt gtggaaagca aactccttga ccataccgga 1800 gggtgcatgt acatctccgg tgtccctggg acagggaaga ctgccactgt tcatgaagtg 1860 atacgctgcc tgcagcaggc agcccaagcc aatgatgttc ctccctttca atacattgag 1920 gtcaatggca tgaagctgac ggagccccac caagtctatg tgcaaatctt gcagaagcta 1980 acaggccaaa aagcaacagc caaccatgcg gcagaactgc tggcaaagca attctgcacc 2040 cgagggtcac ctcaggaaac caccgtcctg cttgtggatg agctcgacct tctgtggact 2100 cacaaacaag acataatgta caatctcttt gactggccca ctcataagga ggcccggctt 2160 gtggtcctgg caattgccaa cacaatggac ctgccagagc gaatcatgat gaaccgggtg 2220 tccagccgac tgggtcttac caggatgtgc ttccagccct atacatatag ccagctgcag 2280 cagatcctaa ggtcccggct caagcatcta aaggcctttg aagatgatgc catccagctg 2340 gtagccagga aggtagcagc actgtctgga gatgcacgac ggtgcctgga catctgcagg 2400 cgtgccacag agatctgtga gttctcccag cagaagcctg actcccctgg cctggtcacc 2460 atagcccact caatggaagc tgtggatgag atgttttcat catcatacat cacggccatc 2520 aaaaattcct ctgttctgga acagagcttc ctgagagcca tcctcgcaga gttccgtcga 2580 tcaggactgg aggaagccac gtttcaacag atatatagtc aacatgtggc actgtgcaga 2640 atggagggac tgccgtaccc caccatgtca gagaccatgg ccgtgtgttc tcacctgggc 2700 tcctgtcgcc tcctgcttgt ggagcccagc aggaacgatc tgctccttcg ggtgcggctc 2760 aacgtcagcc aggatgatgt gctgtatgcg ctgaaagacg agtaaagggg cttcacaagt 2820 taaaagactg gggtcttgct gggttttgtt ttttgagaca gggtcttgct ctgtcgccca 2880 ggctggagtg cagtggcacg atcatggctc actgcagcct tgacttctca ggcttaggtg 2940 accccccaac ctcatcctcc caggtggctg aaactacagg cacatgccac catgcccagc 3000 tgattttttg tagagacagg gcttcaccat gttgccaagc tagtctacaa agcatctgat 3060 tttggaagta catggaattg ttgtaacaaa gtatattgaa tggaaatggc tctcatgtat 3120 tttggaattt tccattaaat aatttgcttt ttcctgaaaa aaaaaaaaaa aaaaaaaaaa 3180 <210> 10 <211> 3172 <212> DNA <213> Homo sapiens <400> 10 ccgctgaatt ctcgaagttt tcttttctcc ttccaccttc ttttcatttc tagtgagaca 60 cacgctttgg tcctggcttt cggcccgtag ttgtagaagg agccctgctg gtgcaggtta 120 gaggtgccgc atcccccgga gctctcgaag tggaggcggt aggaaacgga gggcttgcgg 180 ctagccggag gaagctttgg agccggaagc catggcacac taccccacaa ggctgaagac 240 cagaaaaact tattcatggg ttggcaggcc cttgttggat cgaaaactgc actaccaaac 300 ctatagagaa atgtgtgtga aaacagaagg ttgttccacc gagattcaca tccagattgg 360 acagtttgtg ttgattgaag gggatgatga tgaaaacccg tatgttgcta aattgcttga 420 gttgttcgaa gatgactctg atcctcctcc taagaaacgt gctcgagtac agtggtttgt 480 ccgattctgt gaagtccctg cctgtaaacg gcatttgttg ggccggaagc ctggtgcaca 540 ggaaatattc tggtatgatt acccggcctg tgacagcaac attaatgcgg agaccatcat 600 tggccttgtt cgggtgatac ctttagcccc aaaggatgtg gtaccgacga atctgaaaaa 660 tgagaagaca ctctttgtga aactatcctg gaatgagaag aaattcaggc cactttcctc 720 agaactattt gcggagttga ataaaccaca agagagtgca gccaagtgcc agaaacccgt 780 gagagccaag agtaagagtg cagagagccc ttcttggacc ccagcagaac atgtggccaa 840 aaggattgaa tcaaggcact ccgcctccaa atctcgccaa actcctaccc atcctcttac 900 cccaagagcc agaaagaggc tggagcttgg caacttaggt aaccctcaga tgtcccagca 960 gacttcatgt gcctccttgg attctccagg aagaataaaa cggaaagtgg ccttctcgga 1020 gatcacctca ccttctaaga gatctcagcc tgataaactt caaaccttgt ctccagctct 1080 gaaagcccca gagaaaacca gagagactgg actctcttat actgaggatg acaagaaggc 1140 ttcacctgaa catcgcataa tcctgagaac ccgaattgca gcttcgaaaa ccatagacat 1200 tagagaggag agaacactta cccctatcag tgggggacag agatcttcag tggtgccatc 1260 cgtgattctg aaaccagaaa acatcaaaaa gagggatgca aaagaagcaa aagcccagaa 1320 tgaagcgacc tctactcccc atcgtatccg cagaaagagt tctgtcttga ctatgaatcg 1380 gattaggcag cagcttcggt ttctaggtaa tagtaaaagt gaccaagaag agaaagagat 1440 tctgccagca gcagagattt cagactctag cagtgacgaa gaagaggctt ccacaccgcc 1500 ccttccaagg agagcaccca gaactgtgtc caggaacctg cgatcttcct tgaagtcatc 1560 cttacatacc ctcacgaagg tgccaaagaa gagtctcaag cctagaacgc cacgttgtgc 1620 cgctcctcag atccgtagtc gaagcctggc tgcccaggag ccagccagtg tgctggagga 1680 agcccgactg aggctgcatg tttctgctgt acctgagtct cttccctgtc gggaacagga 1740 attccaagac atctacaatt ttgtggaaag caaactcctt gaccataccg gagggtgcat 1800 gtacatctcc ggtgtccctg ggacagggaa gactgccact gttcatgaag tgatacgctg 1860 cctgcagcag gcagcccaag ccaatgatgt tcctcccttt caatacattg aggtcaatgg 1920 catgaagctg acggagcccc accaagtcta tgtgcaaatc ttgcagaagc taacaggcca 1980 aaaagcaaca gccaaccatg cggcagaact gctggcaaag caattctgca cccgagggtc 2040 acctcaggaa accaccgtcc tgcttgtgga tgagctcgac cttctgtgga ctcacaaaca 2100 agacataatg tacaatctct ttgactggcc cactcataag gaggcccggc ttgtggtcct 2160 ggcaattgcc aacacaatgg acctgccaga gcgaatcatg atgaaccggg tgtccagccg 2220 actgggtctt accaggatgt gcttccagcc ctatacatat agccagctgc agcagatcct 2280 aaggtcccgg ctcaagcatc taaaggcctt tgaagatgat gccatccagc tggtagccag 2340 gaaggtagca gcactgtctg gagatgcacg acggtgcctg gacatctgca ggcgtgccac 2400 agagatctgt gagttctccc agcagaagcc tgactcccct ggcctggtca ccatagccca 2460 ctcaatggaa gctgtggatg agatgttttc atcatcatac atcacggcca tcaaaaattc 2520 ctctgttctg gaacagagct tcctgagagc catcctcgca gagttccgtc gatcaggact 2580 ggaggaagcc acgtttcaac agatatatag tcaacatgtg gcactgtgca gaatggaggg 2640 actgccgtac cccaccatgt cagagaccat ggccgtgtgt tctcacctgg gctcctgtcg 2700 cctcctgctt gtggagccca gcaggaacga tctgctcctt cgggtgcggc tcaacgtcag 2760 ccaggatgat gtgctgtatg cgctgaaaga cgagtaaagg ggcttcacaa gttaaaagac 2820 tggggtcttg ctgggttttg ttttttgaga cagggtcttg ctctgtcgcc caggctggag 2880 tgcagtggca cgatcatggc tcactgcagc cttgacttct caggcttagg tgacccccca 2940 acctcatcct cccaggtggc tgaaactaca ggcacatgcc accatgccca gctgattttt 3000 tgtagagaca gggcttcacc atgttgccaa gctagtctac aaagcatctg attttggaag 3060 tacatggaat tgttgtaaca aagtatattg aatggaaatg gctctcatgt attttggaat 3120 tttccattaa ataatttgct ttttcctgaa aaaaaaaaaa aaaaaaaaaa aa 3172 <210> 11 <211> 3153 <212> DNA <213> Homo sapiens <400> 11 ccggggccac gcgattggcg cgaagttttc ttttctcctt ccaccttctt ttcatttcta 60 gtgagacaca cgctttggtc ctggctttcg gcccgtagtt gtagaaggag ccctgctggt 120 gcaggttaga ggtgccgcat cccccggagc tctcgaagtg gaggcggtag gaaacggagg 180 gcttgcggct agccggagga agctttggag ccggaagcca tggcacacta ccccacaagg 240 ctgaagacca gaaaaactta ttcatgggtt ggcaggccct tgttggatcg aaaactgcac 300 taccaaacct atagagaaat gtgtgtgaaa acagaaggtt gttccaccga gattcacatc 360 cagattggac agtttgtgtt gattgaaggg gatgatgatg aaaacccgta tgttgctaaa 420 ttgcttgagt tgttcgaaga tgactctgat cctcctccta agaaacgtgc tcgagtacag 480 tggtttgtcc gattctgtga agtccctgcc tgtaaacggc atttgttggg ccggaagcct 540 ggtgcacagg aaatattctg gtatgattac ccggcctgtg acagcaacat taatgcggag 600 accatcattg gccttgttcg ggtgatacct ttagccccaa aggatgtggt accgacgaat 660 ctgaaaaatg agaagacact ctttgtgaaa ctatcctgga atgagaagaa attcaggcca 720 ctttcctcag aactatttgc ggagttgaat aaaccacaag agagtgcagc caagtgccag 780 aaacccgtga gagccaagag taagagtgca gagagccctt cttggacccc agcagaacat 840 gtggccaaaa ggattgaatc aaggcactcc gcctccaaat ctcgccaaac tcctacccat 900 cctcttaccc caagagccag aaagaggctg gagcttggca acttaggtaa ccctcagatg 960 tcccagcaga cttcatgtgc ctccttggat tctccaggaa gaataaaacg gaaagtggcc 1020 ttctcggaga tcacctcacc ttctaagaga tctcagcctg ataaacttca aaccttgtct 1080 ccagctctga aagccccaga gaaaaccaga gagactggac tctcttatac tgaggatgac 1140 aagaaggctt cacctgaaca tcgcataatc ctgagaaccc gaattgcagc ttcgaaaacc 1200 atagacatta gagaggagag aacacttacc cctatcagtg ggggacagag atcttcagtg 1260 gtgccatccg tgattctgaa accagaaaac atcaaaaaga gggatgcaaa agaagcaaaa 1320 gcccagaatg aagcgacctc tactccccat cgtatccgca gaaagagttc tgtcttgact 1380 atgaatcgga ttaggcagca gcttcggttt ctaggtaata gtaaaagtga ccaagaagag 1440 aaagagattc tgccagcagc agagatttca gactctagca gtgacgaaga agaggcttcc 1500 acaccgcccc ttccaaggag agcacccaga actgtgtcca ggaacctgcg atcttccttg 1560 aagtcatcct tacataccct cacgaaggtg ccaaagaaga gtctcaagcc tagaacgcca 1620 cgttgtgccg ctcctcagat ccgtagtcga agcctggctg cccaggagcc agccagtgtg 1680 ctggaggaag cccgactgag gctgcatgtt tctgctgtac ctgagtctct tccctgtcgg 1740 gaacaggaat tccaagacat ctacaatttt gtggaaagca aactccttga ccataccgga 1800 gggtgcatgt acatctccgg tgtccctggg acagggaaga ctgccactgt tcatgaagtg 1860 atacgctgcc tgcagcaggc agcccaagcc aatgatgttc ctccctttca atacattgag 1920 gtcaatggca tgaagctgac ggagccccac caagtctatg tgcacatctt gcagaagcta 1980 acaggccaaa aagcaacagc caaccatgcg gcagaactgc tggcaaagca attctgcacc 2040 cgagggtcac ctcaggaaac caccgtcctg cttgtggatg agctcgacct tctgtggact 2100 cacaaacaag acataatgta caatctcttt gactggccca ctcataagga ggcccggctt 2160 gtggtcctgg caattgccaa cacaatggac ctgccagagc gaatcatgat gaaccgggtg 2220 tccagccgac tgggtcttac caggatgtgc ttccagccct atacatatag ccagctgcag 2280 cagatcctaa ggtcccggct caagcatcta aaggcctttg aagatgatgc catccagctg 2340 gtagccagga aggtagcagc actgtctgga gatgcacgac ggtgcctgga catctgcagg 2400 cgtgccacag agatctgtga gttctcccag cagaagcctg actcccctgg cctggtcacc 2460 atagcccact caatggaagc tgtggatgag atgttttcat catcatacat cacggccatc 2520 aaaaattcct ctgttctgga acagagcttc ctgagagcca tcctcgcaga gttccgtcga 2580 tcaggactgg aggaagccac gtttcaacag atatatagtc aacatgtggc actgtgcaga 2640 atggagggac tgccgtaccc caccatgtca gagaccatgg ccgtgtgttc tcacctgggc 2700 tcctgtcgcc tcctgcttgt ggagcccagc aggaacgatc tgctccttcg ggtgcggctc 2760 aacgtcagcc aggatgatgt gctgtatgcg ctgaaagacg agtaaagggg cttcacaagt 2820 taaaagactg gggtcttgct gggttttgtt ttttgagaca gggtcttgct ctgtcgccca 2880 ggctggagtg cagtggcacg atcatggctc actgcagcct tgacttctca ggcttaggtg 2940 accccccaac ctcatcctcc caggtggctg aaactacagg cacatgccac catgcccagc 3000 tgattttttg tagagacagg gcttcaccat gttgccaagc tagtctacaa agcatctgat 3060 tttggaagta catggaattg ttgtaacaaa gtatattgaa tggaaatggc tctcatgtat 3120 tttggaattt tccattaaat aatttgcttt tta 3153 <210> 12 <211> 3136 <212> DNA <213> Homo sapiens <400> 12 ctttggtcct ggctttcggc ccgtagttgt agaaggagcc ctgctggtgc aggttagagg 60 tgccgcatcc cccggagctc tcgaagtgga ggcggtagga aacggagggc ttgcggctag 120 ccggaggaag ctttggagcc ggccatggca cactacccca caaggctgac taccagaaaa 180 acttattcat gggttggcag gcccttgttg gatcgaaaac tgcactacca aacctataga 240 gaaatgtgtg tgaaaacaga aggttgttcc accgagattc acatccagat tggacagttt 300 gtgttgattg aaggggatga tgatgaaaac ccgtatgttg ctaaattgct tgagttgttc 360 gaagatgact ctgatcctcc tcctaagaaa cgtgctcgag tacagtggtt tgtccgattc 420 tgtgaagtcc ctgcctgtaa acggcatttg ttgggccgga agcctggtgc acaggaaata 480 ttctggtatg attacccggc ctgtgacagc aacattaatg cggagaccat cattggcctt 540 gttcgggtga tacctttagc cccaaaggat gtggtaccga cgaatctgaa aaatgagaag 600 acactctttg tgaaactatc ctggaatgag aagaaattca ggccactttc ctcagaacta 660 tttgcggagt tgaataaacc acaagagagt gcagccaagt gccagaaacc cgtgagagcc 720 aagagtaaga gtgcagagag cccttcttgg accccagcag aacatgtggc caaaaggatt 780 gaatcaaggc actccgcctc caaatctcgc caaactccta cccatcctct taccccaaga 840 gccagaaaga ggctggagct tggcaactta ggtaaccctc agatgtccca gcagacttca 900 tgtgcctcct tggattctcc aggaagaata aaacggaaag tggccttctc ggagatcacc 960 tcaccttcta agagatctca gcctgataaa cttcaaacct tgtctccagc tctgaaagcc 1020 ccagagaaaa ccagagagac tggactctct tatactgagg atgacaagaa ggcttcacct 1080 gaacatcgca taatcctgag aacccgaatt gcagcttcga aaaccataga cattagagag 1140 gagagaacac ttacccctat cagtggggga cagagatctt cagtggtgcc atccgtgatt 1200 ctgaaaccag aaaacatcaa aaagagggat gcaaaagaag caaaagccca gaatgaagcg 1260 acctctactc cccatcgtat ccgcagaaag agttctgtct tgactatgaa tcggattagg 1320 cagcagcttc ggtttctagg taatagtaaa agtgaccaag aagagaaaga gattctgcca 1380 gcagcagaga tttcagactc tagcagtgac gaagaagagg cttccacacc gccccttcca 1440 aggagagcac ccagaactgt gtccaggaac ctgcgatctt ccttgaagtc atccttacat 1500 accctcacga aggtgccaaa gaagagtctc aagcctagaa cgccacgttg tgccgctcct 1560 cagatccgta gtcgaagcct ggctgcccag gagccagcca gtgtgctgga ggaagcccga 1620 ctgaggctgc atgtttctgc tgtacctgag tctcttccct gtcgggaaca ggaattccaa 1680 gacatctaca attttgtgga aagcaaactc cttgaccata ccggagggtg catgtacatc 1740 tccggtgtcc ctgggacagg gaagactgcc actgttcatg aagtgatacg ctgcctgcag 1800 caggcagccc aagccaatga tgttcctccc tttcaataca ttgaggtcaa tggcatgaag 1860 ctgacggagc cccaccaagt ctatgtgcaa atcttgcaga agctaacagg ccaaaaagca 1920 acagccaacc atgcggcaga actgctggca aagcaattct gcacccgagg gtcacctcag 1980 gaaaccaccg tcctgcttgt ggatgagctc gaccttctgt ggactcacaa acaagacata 2040 atgtacaatc tctttgactg gcccactcat aaggaggccc ggcttgtggt cctggcaatt 2100 gccaacacaa tggacctgcc agagcgaatc atgatgaacc gggtgtccag ccgactgggt 2160 cttaccagga tgtgcttcca gccctataca tatagccagc tgcagcagat cctaaggtcc 2220 cggctcaagc atctaaaggc ctttgaagat gatgccatcc agctggtagc caggaaggta 2280 gcagcactgt ctggagatgc acgacggtgc ctggacatct gcaggcgtgc cacagagatc 2340 tgtgagttct cccagcagaa gcctgactcc cctggcctgg tcaccatagc ccactcaatg 2400 gaagctgtgg atgagatgtt ttcatcatca tacatcacgg ccatcaaaaa ttcctctgtt 2460 ctggaacaga gcttcctgag agccatcctc gcagagttcc gtcgatcagg actggaggaa 2520 gccacgtttc aacagatata tagtcaacat gtggcactgt gcagaatgga gggactgccg 2580 taccccacca tgtcagagac catggccgtg tgttctcacc tgggctcctg tcgcctcctg 2640 cttgtggagc ccagcaggaa cgatctgctc cttcgggtgc ggctcaacgt cagccaggat 2700 gatgtgctgt atgcgctgaa agacgagtaa aggggcttca caagttaaaa gactggggtc 2760 ttgctgggtt ttgttttttg agacggggtc ttgctctgtc gcccaggctg gagtgcagtg 2820 gcacgatcat ggctcactgc agccttgact tctcaggctt aggtgacccc ccaacctcat 2880 cctcccgggt ggctgaaact acaggcacat gccaccatgc ccagctgatt ttttgtagag 2940 acagggcttc accatgttgc caagctagtc tacaaagcat ctgattttgg aagtacatgg 3000 aattgttgta acaaagtata ttgaatggaa atggctctca tgtattttgg aattttccat 3060 taaataattt gctttttcct aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 3120 aaaaaaaaaa aaaaaa 3136 <210> 13 <211> 2528 <212> DNA <213> Homo sapiens <400> 13 gggaaatccc gagtgcatct ggaatacgca gagtcagtaa gaccatggct acgtcctcga 60 tgtctaaggg ttgctttgtt tttaagccaa actccaaaaa gagaaagatc tctctgccaa 120 tagaggacta ttttaacaaa gggaaaaatg agcctgagga cagtaagctt cgattcgaaa 180 cttatcagtt gatatggcag cagatgaaat ctgaaaatga gcgactacaa gaggaattaa 240 ataaaaactt gtttgacaat ctgattgaat ttctgcaaaa atcacattct ggattccaga 300 agaattcaag agacttgggc ggtcaaataa aactcagaga aattccaact gctgctcttg 360 ttcttggtgt gaatgtcaca gatcatgatt tgacattcgg aagtctaaca gaggcccttc 420 agaataatgt cacaccatat gtagtctcat tgcaagctaa agattgtcca gatatgaaac 480 attttttgca aaagttgatc tcacagttga tggactgctg tgtagatata aaatccaaag 540 aggaggaaag tgttcacgtc acccaaagaa agacacatta ttcaatggat tcactttcca 600 gttggtatat gactgtcaca cagaagacgg acccaaaaat gctaagcaaa aaaaggacta 660 cttctagcca atggcagtct cctcctgttg tcgttatctt gaaggatatg gaaagctttg 720 ccacaaaagt actacaagac ttcataatta tcagcagtca acatctccat gaatttccac 780 taatactcat ttttggaata gccacatctc ctattatcat ccaccgattg cttcctcatg 840 cagtatcatc tctattgtgc atagaactgt tccaatcttt gtcttgtaag gagcacctga 900 ctacggtact cgataagcta cttcttacaa ctcagtttcc ctttaaaata aatgaaaaag 960 tattacaggt tctgaccaac atctttttgt atcatgattt ctcagttcaa aactttataa 1020 aaggacttca gctttctcta ttagagcatt tctattccca gcccttaagt gtcctgtgct 1080 gtaatcttcc agaagccaaa agaagaataa attttttatc aaataatcaa tgtgaaaaca 1140 tccgacgtct accatctttt aggaggtacg tggaaaagca agcttcagaa aagcaagttg 1200 cgctcttgac caatgagaga tatttgaagg aggaaacaca attattacta gaaaacctgc 1260 atgtttatca tatgaattac ttcctggttt tgagatgtct tcataagttc acctcttctc 1320 ttcccaagta tccactaggt cgacagatca gagagttgta ctgtacatgt ttagaaaaga 1380 acatatggga ttcagaggag tatgcatcag tcttgcagct gctgaggatg ttggcaaagg 1440 atgaactgat gaccatactt gagaaatgtt tcaaggtttt taagtcttat tgtgaaaacc 1500 accttggcag cacagctaag agaatagagg agttcctggc ccagtttcag agcctcgatg 1560 cagaaaccaa agaggaagaa gatgcttctg ggtcacagcc aaaggggctt cagaagacag 1620 acctctatca tcttcagaag tccttattgg aaatgaagga gttaagaaga agtaagaagc 1680 aaaccaaatt tgaagtactc agagaaaatg ttgtgaactt cattgactgt ctagtgagag 1740 aataccttct gcctcctgag acacagcctc tccatgaggt ggtgtacttc agtgctgccc 1800 atgcccttcg tgagcattta aatgctgctc cgcgaattgc cctccatact gcactcaaca 1860 atccttacta ttatctcaag aatgaagcac tgaaaagcga agaaggctgc attccgaata 1920 tcgccccaga catctgcata gcatacaaac tgcacctaga gtgtagcagg ctcatcaacc 1980 tcgtggactg gtcagaggct tttgcaacag ttgtgacagc tgctgaaaaa atggatgcaa 2040 attctgcaac ctcagaagaa atgaatgaaa ttatccatgc tcggtttatt agagctgttt 2100 ctgaactaga acttttagga tttataaaac ctaccaaaca gaagactgac catgtggcaa 2160 gactaacatg gggaggctgc tagaaagcaa ataagcaaag ccagaactat cacatttagc 2220 ttaagagaaa aaggtgacca gtcatattta catatattag aggagcctgt tttgttgaga 2280 agataaatgt gtaaccccca ttgatgttta accagaaaag tacattgcta accccaaaca 2340 ggcatgtatc aaaacacctg tggagtactt tagactccaa caaataataa tgtaactaaa 2400 actgctcaca cattttactg tactttccaa agtcattact aaattgtgag taaatcattc 2460 ttgaacttag agtatgtaaa tgtaataaat tccgttatcc aggagtataa aaaaaaaaaa 2520 aaaaaaaa 2528 <210> 14 <211> 2528 <212> DNA <213> Homo sapiens <400> 14 gggaaatccc gagtgcatct ggaatacgca gagtcagtaa gaccatggct acgtcctcga 60 tgtctaaggg ttgctttgtt tttaagccaa actccaaaaa gagaaagatc tctctgccaa 120 tagaggacta ttttaacaaa gggaaaaatg agcctgagga cagtaagctt cgattcgaaa 180 cttatcagtt gatatggcag cagatgaaat ctgaaaatga gcgactacaa gaggaattaa 240 ataaaaactt gtttgacaat ctgattgaat ttctgcaaaa atcacattct ggattccaga 300 agaattcaag agacttgggc ggtcaaataa aactcagaga aattccaact gctgctcttg 360 ttcttggtgt gaatgtcaca gatcatgatt tgacattcgg aagtctaaca gaggcccttc 420 agaataatgt cacaccatat gtagtctcat tgcaagctaa agattgtcca gatatgaaac 480 attttttgca aaagttgatc tcacagttga tggactgctg tgtagatata aaatccaaag 540 aggaggaaag tgttcacgtc acccaaagaa agacacatta ttcaatggat tcactttcca 600 gttggtatat gactgtcaca cagaagacgg acccaaaaat gctaagcaaa aaaaggacta 660 cttctagcca atggcagtct cctcctgttg tcgttatctt gaaggatatg gaaagctttg 720 ccacaaaagt actacaagac ttcataatta tcagcagtca acatctccat gaatttccac 780 taatactcat ttttggaata gccacatctc ctattatcat ccaccgattg cttcctcatg 840 cagtatcatc tctattgtgc atagaactgt tccaatcttt gtcttgtaag gagcacctga 900 ctacggtact cgataagcta cttcttacaa ctcagtttcc ctttaaaata aatgaaaaag 960 tattacaggt tctgaccaac atctttttgt atcatgattt ctcagttcaa aactttataa 1020 aaggacttca gctttctcta ttagagcatt tctattccca gcccttaagt gtcctgtgct 1080 gtaatcttcc agaagccaaa agaagaataa attttttatc aaataatcaa tgtgaaaaca 1140 tccgacgtct accatctttt aggaggtacg tggaaaagca agcttcagaa aagcaagttg 1200 cgctcttgac caatgagaga tatttgaagg aggaaacaca attattacta gaaaacctgc 1260 atgtttatca tatgaattac ttcctggttt tgagatgtct tcataagttc acctcttctc 1320 ttcccaagta tccactaggt cgacagatca gagagttgta ctgtacatgt ttagaaaaga 1380 acatatggga ttcagaggag tatgcatcag tcttgcagct gctgaggatg ttggcaaagg 1440 atgaactgat gaccatactt gagaaatgtt tcaaggtttt taagtcttat tgtgaaaacc 1500 accttggcag cacagctaag agaatagagg agttcctggc ccagtttcag agcctcgatg 1560 aaaccaaaga ggaagaagat gcttctgggt cacagccaaa ggggcttcag aagacagacc 1620 tctatcatct tcagaagtcc ttattggaaa tgaaggagtt aagaagaagt aagaagcaaa 1680 ccaaatttga agtactcaga gaaaatgttg tgaacttcat tgactgtcta gtgagagaat 1740 accttctgcc tcctgagaca cagcctctcc atgaggtggt gtacttcagt gctgcccatg 1800 cccttcgtga gcatttaaat gctgctccgc gaattgccct ccatactgca ctcaacaatc 1860 cttactatta tctcaagaat gaagcactga aaagcgaaga aggctgcatt ccgaatatcg 1920 ccccagacat ctgcatagca tacaaactgc acctagagtg tagcaggctc atcaacctcg 1980 tggactggtc agaggctttt gcaacagttg tgacagctgc tgaaaaaatg gatgcaaatt 2040 ctgcaacctc agaagaaatg aatgaaatta tccatgctcg gtttattaga gctgtttctg 2100 aactagaact tttaggattt ataaaaccta ccaaacagaa gactgaccat gtggcaagac 2160 taacatgggg aggctgctag aaagcaaata agcaaagcca gaactatcac atttagctta 2220 agagaaaaag gtgaccagtc atatttacat atattagagg agcctgtttt gttgagaaga 2280 taaatgtgta acccccattg atgtttaacc agaaaagtac attgctaacc ccaaacaggc 2340 atgtatcaaa acacctgtgg agtactttag actccaacaa ataataatgt aactaaaact 2400 gctcacacat tttactgtac tttccaaagt cattactaaa ttgtgagtaa atcattcttg 2460 aacttagagt atgtaaatgt aataaattcc gttatccagg agtataaaaa aaaaaaaaaa 2520 aaaaaaaa 2528 <210> 15 <211> 2505 <212> DNA <213> Homo sapiens <400> 15 ggcacgaggg cagagtcagt aagaccatgg ctacgtcctc gatgtctaag ggttgctttg 60 tttttaagcc aaactccaaa aagagaaaga tctctctgcc aatagaggac tattttaaca 120 aagggaaaaa tgagcctgag gacagtaagc ttcgattcga aacttatcag ttgatatggc 180 agcagatgaa atctgaaaat gagcgactac aagaggaatt aaataaaaac ttgtttgaca 240 atctgattga atttctgcaa aaatcacatt ctggattcca gaagaattca agagacttgg 300 gcggtcaaat aaaactcaga gaaattccaa ctgctgctct tgttcttggt gtgaatgtca 360 cagatcatga tttgacattc ggaagtctaa cagaggccct tcagaataat gtcacaccat 420 atgtagtctc attgcaagct aaagattgtc cagatatgaa acattttttg caaaagttga 480 tctcacagtt gatggactgc tgtgtagata taaaatccaa agaggaggaa agtgttcacg 540 tcacccaaag aaagacacat tattcaatgg attcactttc cagttggtat atgactgtca 600 cacagaagac ggacccaaaa atgctaagca aaaaaaggac tacttctagc caatggcagt 660 ctcctcctgt tgtcgttatc ttgaaggata tggaaagctt tgccacaaaa gtactacaag 720 acttcataat tatcagcagt caacatctcc atgaatttcc actaatactc atttttggaa 780 tagccacatc tcctattatc atccaccgat tgcttcctca tgcagtatca tctctattgt 840 gcatagaact gttccaatct ttgtcttgta aggagcacct gactacggta ctcgataagc 900 tacttcttac aactcagttt ccctttaaaa taaatgaaaa agtattacag gttctgacca 960 acatcttttt gtatcatgat ttctcagttc aaaactttat aaaaggactt cagctttctc 1020 tattagagca tttctattcc cagcccttaa gtgtcctgtg ctgtaatctt ccagaagcca 1080 aaagaagaat aaatttttta tcaaataatc aatgtgaaaa catccgacgt ctaccatctt 1140 ttaggaggta cgtggaaaag caagcttcag aaaagcaagt tgcgctcttg accaatgaga 1200 gatatttgaa ggaggaaaca caattattac tagaaaacct gcatgtttat catatgaatt 1260 acttcctggt tttgagatgt cttcataagt tcacctcttc tcttcccaag tatccactag 1320 gtcgacagat cagagagttg tactgtacat gtttagaaaa gaacatatgg gattcagagg 1380 agtatgcatc agtcttgcag ctgctgagga tgttggcaaa ggatgaactg atgaccatac 1440 ttgagaaatg tttcaaggtt tttaagtctt attgtgaaaa ccaccttggc agcacagcta 1500 agagaataga ggagttcctg gcccagtttc agagcctcga tgaaaccaaa gaggaagaag 1560 atgcttctgg gtcacagcca aaggggcttc agaagacaga cctctatcat cttcagaagt 1620 ccttattgga aatgaaggag ttaagaagaa gtaagaagca aaccaaattt gaagtactca 1680 gagaaaatgt tgtgaacttc attgactgtc tagtgagaga ataccttctg cctcctgaga 1740 cacagcctct ccatgaggtg gtgtacttca gtgctgccca tgcccttcgt gagcatttaa 1800 atgctgctcc gcgaattgcc ctccatactg cactcaacaa tccttactat tatctcaaga 1860 atgaagcact gaaaagcgaa gaaggctgca ttccgaatat cgccccagac atctgcatag 1920 catacaaact gcacctagag tgtagcaggc tcatcaacct cgtggactgg tcagaggctt 1980 ttgcaacagt tgtgacagct gctgaaaaaa tggatgcaaa ttctgcaacc tcagaagaaa 2040 tgaatgaaat tatccatgct cggtttatta gagctgtttc tgaactagaa cttttaggat 2100 ttataaaacc taccaaacag aagactgacc atgtggcaag actaacatgg ggaggctgct 2160 agaaagcaaa taagcaaagc cagaactatc acatttagct taagagaaaa aggtgaccag 2220 tcatatttac atatattaga ggagcctgtt ttgttgagaa gataaatgtg taacccccat 2280 tgatgtttaa ccagaaaagt acattgctaa ccccaaacag gcatgtatca aaacacctgt 2340 ggagtacttt agactccaac aaataataat gtaactaaaa ctgctcacac attttactgt 2400 actttccaaa gtcattacta aattgtgagt aaatcattct tgaacttaga gtatgtaaat 2460 gtaataaatt ccgttatcca ggagtataaa aaaaaaaaaa aaaaa 2505 <210> 16 <211> 2496 <212> DNA <213> Homo sapiens <400> 16 cgagtgcatc tggaatacgc agagtcagta agaccatggc tacgtcctcg atgtctaagg 60 gttgctttgt ttttaagcca aactccaaaa agagaaagat ctctctgcca atagaggact 120 attttaacaa agggaaaaat gagcctgagg acagtaagct tcgattcgaa acttatcagt 180 tgatatggca gcagatgaaa tctgaaaatg agcgactaca agaggaatta aataaaaact 240 tgtttgacaa tctgattgaa tttctgcaaa aatcacattc tggattccag aagaattcaa 300 gagacttggg cggtcaaata aaactcagag aaattccaac tgctgctctt gttcttggtg 360 tgaatgtcac agatcatgat ttgacattcg gaagtctaac agaggccctt cagaataatg 420 tcacaccata tgtagtctca ttgcaagcta aagattgtcc agatatgaaa cattttttgc 480 aaaagttgat ctcacagttg atggactgct gtgtagatat aaaatccaaa gaggaggaaa 540 gtgttcacgt cacccaaaga aagacacatt attcaatgga ttcactttcc agttggtata 600 tgactgtcac acagaagacg gacccaaaaa tgctaagcaa aaaaaggact acttctagcc 660 aatggcagtc tcctcctgtt gtcgttatct tgaaggatat ggaaagcttt gccacaaaag 720 tactacaaga cttcataatt atcagcagtc aacatctcca tgaatttcca ctaatactca 780 tttttggaat agccacatct cctattatca tccaccgatt gcttcctcat gcagtatcat 840 ctctattgtg catagaactg ttccaatctt tgtcttgtaa ggagcacctg actacggtac 900 tcgataagct acttcttaca actcagtttc cctttaaaat aaatgaaaaa gtattacagg 960 ttctgaccaa catctttttg tatcatgatt tctcagttca aaactttata aaaggacttc 1020 agctttctct attagagcat ttctattccc agcccttaag tgtcctgtgc tgtaatcttc 1080 cagaagccaa aagaagaata aattttttat caaataatca atgtgaaaac atccgacgtc 1140 taccatcttt taggaggtac gtggaaaagc aagcttcaga aaagcaagtt gcgctcttga 1200 ccaatgagag atatttgaag gaggaaacac aattattact agaaaacctg catgtttatc 1260 atatgaatta cttcctggtt ttgagatgtc ttcataagtt cacctcttct cttcccaagt 1320 atccactagg tcgacagatc agagagttgt actgtacatg tttagaaaag aacatatggg 1380 attcagagga gtatgcatca gtcttgcagc tgctgaggat gttggcaaag gatgaactga 1440 tgaccatact tgagaaatgt ttcaaggttt ttaagtctta ttgtgaaaac caccttggca 1500 gcacagctaa gagaatagag gagttcctgg cccagtttca gagcctcgat gaaaccaaag 1560 aggaagaaga tgcttctggg tcacagccaa aggggcttca gaagacagac ctctatcatc 1620 ttcagaagtc cttattggaa atgaaggagt taagaagaag taagaagcaa accaaatttg 1680 aagtactcag agaaaatgtt gtgaacttca ttgactgtct agtgagagaa taccttctgc 1740 ctcctgagac acagcctctc catgaggtgg tgtacttcag tgctgcccat gcccttcgtg 1800 agcatttaaa tgctgctccg cgaattgccc tccatactgc actcaacaat ccttactatt 1860 atctcaagaa tgaagcactg aaaagcgaag aaggctgcat tccgaatatc gccccagaca 1920 tctgcatagc atacaaactg cacctagagt gtagcaggct catcaacctc gtggactggt 1980 cagaggcttt tgcaacagtt gtgacagctg ctgaaaaaat ggatgcaaat tctgcaacct 2040 cagaagaaat gaatgaaatt atccatgctc ggtttattag agctgtttct gaactagaac 2100 ttttaggatt tataaaacct accaaacaga agactgacca tgtggcaaga ctaacatggg 2160 gaggctgcta gaaagcaaat aagcaaagcc agaactatca catttagctt aagagaaaaa 2220 ggtgaccagt catatttaca tatattagag gagcctgttt tgttgagaag ataaatgtgt 2280 aacccccatt gatgtttaac cagaaaagta cattgctaac cccaaacagg catgtatcaa 2340 aacacctgtg gagtacttta gactccaaca aataataatg taactaaaac tgctcacaca 2400 ttttactgta ctttccaaag tcattactaa attgtgagta aatcattctt gaacttagag 2460 tatgtaaatg taataaattc cgttatccag gagtat 2496 <210> 17 <211> 2484 <212> DNA <213> Homo sapiens <400> 17 atggctacgt cctcgatgtc taagggttgc tttgttttta agccaaactc caaaaagaga 60 aagatctctc tgccaataga ggactatttt aacaaaggga aaaatgagcc tgaggacagt 120 aagcttcgat tcgaaactta tcagttgata tggcagcaga tgaaatctga aaatgagcga 180 ctacaagagg aattaaataa aaacttgttt gacaatctga ttgaatttct gcaaaaatca 240 cattctggat tccagaagaa ttcaagagac ttgggcggtc aaataaaact cagagaaatt 300 ccaactgctg ctcttgttct tggtgtgaat gtcacagatc atgatttgac attcggaagt 360 ctaacagagg cccttcagaa taatgtcaca ccatatgtag tctcattgca agctaaagat 420 tgtccagata tgaaacattt tttgcaaaag ttgatctcac agttgatgga ctgctgtgta 480 gatataaaat ccaaagagga ggaaagtgtt cacgtcaccc aaagaaagac acattattca 540 atggattcac tttccagttg gtatatgact gtcacacaga agacggaccc aaaaatgcta 600 agcaaaaaaa ggactacttc tagccaatgg cagtctcctc ctgttgtcgt tatcttgaag 660 gatatggaaa gctttgccac aaaagtacta caagacttca taattatcag cagtcaacat 720 ctccatgaat ttccactaat actcattttt ggaatagcca catctcctat tatcatccac 780 cgattgcttc ctcatgcagt atcatctcta ttgtgcatag aactgttcca atctttgtct 840 tgtaaggagc acctgactac ggtactcgat aagctacttc ttacaactca gtttcccttt 900 aaaataaatg aaaaagtatt acaggttctg accaacatct ttttgtatca tgatttctca 960 gttcaaaact ttataaaagg acttcagctt tctctattag agcatttcta ttcccagccc 1020 ttaagtgtcc tgtgctgtaa tcttccagaa gccaaaagaa gaataaattt tttatcaaat 1080 aatcaatgtg aaaacatccg acgtctacca tcttttagga ggtacgtgga aaagcaagct 1140 tcagaaaagc aagttgcgct cttgaccaat gagagatatt tgaaggagga aacacaatta 1200 ttactagaaa acctgcatgt ttatcatatg aattacttcc tggttttgag atgtcttcat 1260 aagttcacct cttctcttcc caagtatcca ctaggtcgac agatcagaga gttgtactgt 1320 acatgtttag aaaagaacat atgggattca gaggagtatg catcagtctt gcagctgctg 1380 aggatgttgg caaaggatga actgatgacc atacttgaga aatgtttcaa ggtttttaag 1440 tcttattgtg aaaaccacct tggcagcaca gctaagagaa tagaggagtt cctggcccag 1500 tttcagagcc tcgatgaaac caaagaagaa gaagatgctt ctgggtcaca gccaaagggg 1560 cttcagaaga cagacctcta tcatcttcag aagtccttat tggaaatgaa ggagttaaga 1620 agaagtaaga agcaaaccaa atttgaagta ctcagagaaa atgttgtgaa cttcattgac 1680 tgtctagtga gagaatacct tctgcctcct gagacacagc ctctccatga ggtggtgtac 1740 ttcagtgctg cccatgccct tcgtgagcat ttaaatgctg ctccgcgaat tgccctccat 1800 actgcactca acaatcctta ctattatctc aagaatgaag cactgaaaag cgaagaaggc 1860 tgcattccga atatcgcccc agacatctgc atagcataca aactgcacct agagtgtagc 1920 aggctcatca acctcgtgga ctggtcagag gcttttgcaa cagttgtgac agctgctgaa 1980 aaaatggatg caaattctgc aacctcagaa gaaatgaatg aaattatcca tgctcggttt 2040 attagagctg tttctgaact agaactttta ggatttataa aacctaccaa acagaagact 2100 gaccatgtgg caagactaac atggggaggc tgctagaaag caaataagca aagccagaac 2160 tatcacattt agcttaagag aaaaaggtga ccagtcatat ttacatatat tagaggagcc 2220 tgttttgttg agaagataaa tgtgtaaccc ccattgatgt ttaaccagaa aagtacattg 2280 ctaaccccaa acaggcatgt atcaaaacac ctgtggagta ctttagactc caacaaataa 2340 taatgtaact aaaactgctc acacatttta ctgtactttc caaagtcatt actaaattgt 2400 gagtaaatca ttcttgaact tagagtatgt aaatgtaata aattccgtta tccaggagta 2460 taaaaaaaaa aaaaaaaaaa aaaa 2484 <210> 18 <211> 2524 <212> DNA <213> Homo sapiens <400> 18 gaagggggag tgcatctgga atacgcagag tcagtaagac catggctacg tcctcgatgt 60 ctaagggttg ctttgttttt aagccaaact ccaaaaagag aaagatctct ctgccaatag 120 aggactattt taacaaaggg aaaaatgagc ctgaggacag taagcttcga ttcgaaactt 180 atcagttgat atggcagcag atgaaatctg aaaatgagcg actacaagag gaattaaata 240 aaaacttgtt tgacaatctg attgaatttc tgcaaaaatc acattctgga ttccagagga 300 attcaagaga cttgggcggt caaataaaac tcagagaaat tccaactgct gctcttgttc 360 ttggtgtgaa tgtcacagat catgatttga cattcggaag tctaacagag gcccttcaga 420 ataatgtcac accatatgta gtctcattgc gagctaaaga ttgtccagat atgaaacatt 480 ttttgcaaaa gttgatctca cagttgatgg actgctgtgt agatataaaa tccaaagagg 540 aggaaagtgt tcacgtcacc caaagaaaga cacattattc aatggattca ctttccagtt 600 ggtatatgac tgtcacacag aagacggacc caaaaatgct aagcaaaaaa aggactactt 660 ctagccaatg gcagtctcct cctgttgtcg ttatcttgaa ggatatggaa agctttgcca 720 caaaagtact acaagacttc ataattatca gcagtcaaca tctccatgaa tttccactaa 780 tactcatttt tggaatagcc acatctccta ttatcatcca ccgattgctt cctcatgcag 840 tatcatctct attgtgcata gaactgttcc aatctttgtc ttgtaaggag cacctgacta 900 cggtactcga taagctactt cttacaactc agtttccctt taaaataaat gaaaaagtat 960 tacaggttct gaccaacatc tttttgtatc atgatttctc agttcaaaac tttataaaag 1020 gacttcagct ttctctatta gagcatttct attcccagcc cttaagtgtc ctgtgctgta 1080 atcttccaga agccaaaaga agaataaatt ttttatcaaa taatcaatgt gaaaacatcc 1140 gacgtctacc atcttttagg aggtacgtgg aaaagcaagc ttcagaaaag caagttgcgc 1200 tcttgaccaa tgagagatat ttgaaggagg aaacacaatt attactagaa aacctgcatg 1260 tttatcatat gaattacttc ctggttttga gatgtcttca taagttcacc tcttctcttc 1320 ccaagtatcc actaggtcga cagatcagag agttgtactg tacatgttta gaaaagaaca 1380 tatgggattc agaggagtat gcatcagtct tgcagctgct gaggatgttg gcaaaggatg 1440 aactgatgac catacttgag aaatgtttca aggtttttaa gtcttattgt gaaaaccacc 1500 ttggcagcac agctaagaga atagaggagt tcctggccca gtttcagagc ctcgatgcag 1560 aaaccaaaga ggaagaagat gcttctgggt cacagccaaa ggggcttcag aagacagacc 1620 tctatcatct tcagaggtcc ttattggaaa tgaaggagtt aagaagaagt aagaagcaaa 1680 ccaaatttga agtactcaga gaaaatgttg tgaacttcat tgactgtcta gtgagagaat 1740 accttctgcc tcctgagaca cagcctctcc atgaggtggt gtacttcagt gccgcccatg 1800 cccttcgtga gcatttaaat gctgctccgc gaattgccct ccatactgca ctcaacaatc 1860 cttactatta tctcaagaat gaagcactga aaagcgaaga aggctgcatt ccgaatatcg 1920 ccccagacat ctgcatagca tacaaactgc acctagagtg tagcaggctc atcaacctcg 1980 tggactggtc agaggctttt gcaacagttg tgacagctgc tgaaaaaatg gacgcaaatt 2040 ctgcaacctc agaagaaatg aatgaaatta tccatgctcg gtttattaga gctgtttctg 2100 aactagaact tttaggattt ataaaaccta ccaaacagaa gactgaccat gtggcaagac 2160 taacatgggg aggctgctag aaagcaaata agcaaagcca gaactatcac atttagctta 2220 agagaaaaag gtgaccagtc atatttacat atattagagg agcctgtttt gttgagaaga 2280 taaatgtgta acccccattg atgtttaacc agaaaagtac attgctaacc ccaaacaggc 2340 atgtatcaaa acacctgtgg agtactttag actccaacaa aataataatg taactaaaac 2400 tgctcacaca ttttactgta ctttccaaag tcattactaa attgtgagta aatcattctt 2460 gaacttagag tatgtaaatg tgataaattc cgttatccag gagtaaaaaa aaaaaaaaaa 2520 aaaa 2524 <210> 19 <211> 2510 <212> DNA <213> Homo sapiens <400> 19 ctggaatacg cagagtcagt aagaccatgg ctacgtcctc gatgtctaag ggttgctttg 60 tttttaagcc aaactccaaa aagagaaaga tctctctgcc aatagaggac tattttaaca 120 aagggaaaaa tgagcctgag gacagtaagc ttcgattcga aacttatcag ttgatatggc 180 agcagatgaa atctgaaaat gagcgactac aagaggaatt aaataaaaac ttgtttgaca 240 atctgattga atttctgcaa aaatcacatt ctggattcca gaagaattca agagacttgg 300 gcggtcaaat aaaactcaga gaaattccaa ctgctgctct tgttcttggt gtgaatgtca 360 cagatcatga tttgacattc ggaagtctaa cagaggccct tcagaataat gtcacaccat 420 atgtagtctc attgcaagct aaagattgtc cagatatgaa acattttttg caaaagttga 480 tctcacagtt gatggactgc tgtgtagata taaaatccaa agaggaggaa agtgttcacg 540 tcacccaaag aaagacacat tattcaatgg attcactttc cagttggtat atgactgtca 600 cacagaagac ggacccaaaa atgctaagca aaaaaaggac tacttctagc caatggcagt 660 ctcctcctgt tgtcgttatc ttgaaggata tggaaagctt tgccacaaaa gtactacaag 720 acttcataat tatcagcagt caacatctcc atgaatttcc actaatactc atttttggaa 780 tagccacatc tcctattatc atccaccgat tgcttcctca tgcagtatca tctctattgt 840 gcatagaact gttccaatct ttgtcttgta aggagcacct gactacggta ctcgataagc 900 tacttcttac aactcagttt ccctttaaaa taaatgaaaa agtattacag gttctgacca 960 acatcttttt gtatcatgat ttctcagttc aaaactttat aaaaggactt cagctttctc 1020 tattagagca tttctattcc cagcccttaa gtgtcctgtg ctgtaatctt ccagaagcca 1080 aaagaagaat aaatttttta tcaaataatc aatgtgaaaa catccgacgt ctaccatctt 1140 ttaggaggta cgtggaaaag caagcttcag aaaagcaagt tgcgctcttg accaatgaga 1200 gatatttgaa ggaggaaaca caattattac tagaaaacct gcatgtttat catatgaatt 1260 acttcctggt tttgagatgt cttcataagt tcacctcttc tcttcccaag tatccactag 1320 gtcgacagat cagagagttg tactgtacat gtttagaaaa gaacatatgg gattcagagg 1380 agtatgcatc agtcttgcag ctgctgagga tgttggcaaa ggatgaactg atgaccatac 1440 ttgagaaatg tttcaaggtt tttaagtctt attgtgaaaa ccaccttggc agcacagcta 1500 agagaataga ggagttcctg gcccagtttc agagcctcga tgaaaccaaa gaagaagaag 1560 atgcttctgg gtcacagcca aaggggcttc agaagacaga cctctatcat cttcagaagt 1620 ccttattgga aatgaaggag tttagaagaa gtaagaagca aaccaaattt gaagtactca 1680 gagaaaatgt tgtgaacttc attgactgtc tagtgagaga ataccttctg cctcctgaga 1740 cacagcctct ccatgaggtg gtgtacttca gtgctgccca tgcccttcgt gagcatttaa 1800 atgctgctcc gcgaattgcc ctccatactg cactcaacaa tccttactat tatctcaaga 1860 atgaagcact gaaaagcgaa gaaggctgca ttccgaatat cgccccagac atctgcatag 1920 catacaaact gcacctagag tgtagcaggc tcatcaacct cgtggactgg tcagaggctt 1980 ttgcaacagt tgtgacagct gctgaaaaaa tggatgcaaa ttctgcaacc tcagaagaaa 2040 tgaatgaaat tatccatgct cggtttatta gagctgtttc tgaactagaa cttttaggat 2100 ttataaaacc taccaaacag aagactgacc atgtggcaag actaacatgg ggaggctgct 2160 agaaagcaaa taagcaaagc cagaactatc acatttagct taagagaaaa aggtgaccag 2220 tcatatttac atatattaga ggagcctgtt ttgttgagaa gataaatgtg taacccccat 2280 tgatgtttaa ccagaaaagt acattgctaa ccccaaacag gcatgtatca aaacacctgt 2340 ggagtacttt agactccaac aaataataat gtaactaaaa ctgctcacac attttactgt 2400 actttccaaa gtcattacta aattgtgagt aaatcattct tgaacttaga gtatgtaaat 2460 gtaataaatt ccgttatcca ggagtataaa aaaaaaaaaa aaaaaaaaaa 2510 <210> 20 <211> 2047 <212> DNA <213> Homo sapiens <400> 20 cgcagagtca gtaagaccat ggctacgtcc tcgatgtcta agggttgctt tgtttttaag 60 ccaaactcca aaaagagaaa gatctctctg ccaatagagg actattttaa caaagggaaa 120 aatgagcctg aggacagtaa gcttcgattc gaaacttatc agttgatatg gcagcagatg 180 aaatctgaaa atgagcgact acaagaggaa ttaaataaaa acttgtttga caatctgatt 240 gaatttctgc aaaaatcaca ttctggattc cagaagaatt caagagactt gggcggtcaa 300 ataaaactca gagaaattcc aactgctgct cttgttcttg gtgtgaatgt cacagatcat 360 gatttgacat tcggaagtct aacagaggcc cttcagaata atgtcacacc atatgtagtc 420 tcattgcaag ctaaagattg tccagatatg aaacattttt tgcaaaagtt gatctcacag 480 ttgatggact gctgtgtaga tataaaatcc aaagaggagg aaagtgttca cgtcacccaa 540 agaaagacac attattcaat ggattcactt tccagttggt atatgactgt cacacagaag 600 acggacccaa aaatgctaag caaaaaaagg actacttcta gccaatggca gtctcctcct 660 gttgtcgtta tcttgaagga tatggaaagc tttgccacaa aagtactaca agacttcata 720 attatcagca gtcaacatct ccatgaattt ccactaatac tcatttttgg aatagccaca 780 tctcctatta tcatccaccg attgcttcct catgcagtat catctctatt gtgcatagaa 840 ctgttccaat ctttgtcttg taaggagcac ctgactacgg tactcgataa gctacttctt 900 acaactcagt ttccctttaa aataaatgaa aaagtattac aggttctgac caacatcttt 960 ttgtatcatg atttctcagt tcaaaacttt ataaaaggac ttcagctttc tctattagag 1020 catttctatt cccagccctt aagtgtcctg tgctgtaatc ttccagaagc caaaagaaga 1080 ataaattttt tatcaaataa tcaatgtgaa aacatccgac gtctaccatc ttttaggagg 1140 tacgtggaaa agcaagcttc agaaaagcaa gttgcgctct tgaccaatga gagatatttg 1200 aaggaggaaa cacaattatt actagaaaac ctgcatgttt atcatatgaa ttacttcctg 1260 gttttgagat gtcttcataa gttcacctct tctcttccca agtatccact aggtcgacag 1320 atcagagagt tgtactgtac atgtttagaa aagaacatat gggattcaga ggagtatgca 1380 tcagtcttgc agctgctgag gatgttggca aaggatgaac tgatgaccat acttgagaaa 1440 tgtttcaagg tttttaagtc ttattgtgaa aaccaccttg gcagcacagc taagagaata 1500 gaggagttcc tggcccagtt tcagagcctc gatgcagaaa ccaaagagga agaagatgct 1560 tctgggtcac agccaaaggg gcttcagaag acagacctct atcatcttca gaagtcctta 1620 ttggaaatga aggagttaag aagaagtaag aagcaaacca aatttgaagt actcagagaa 1680 aatgttgtga acttcattga ctgtctagtg agagaatacc ttctgcctcc tgagacacag 1740 cctctccatg aggtggtgta cttcagtgct gcccatgccc ttcgtgagca tttaaatgct 1800 gctccgcgaa ttgccctcca tactgcactc aacaatcctt actattatct caagaatgaa 1860 gcactgaaaa gcgaagaagg ctgcattccg aatatcgccc cagacatctg catagcatac 1920 aaactgcacc tagagtgtag caggctcatc aacctcgtgg actggtcaga ggcttttgca 1980 acagttgtga cagctgctga aaaaatggat gcaaattctg caacctcaga agaaaaaaaa 2040 aaaaaaa 2047 <210> 21 <211> 2152 <212> DNA <213> Homo sapiens <400> 21 ggcacgaggg atttgacatt cggaagtcta acagaggccc ttcagaataa tgtcacacca 60 tatgtagtct cattgcaagc taaagattgt ccagatatga aacatttttt tgcaaaagtt 120 gatctcacag ttgatggact gctgtgtaga tataaaatcc aaagaggagg aaagtgttca 180 cgtcacccaa agaaagacac attattcaat ggattcactt tccagttggt atatgactgt 240 cacacagaag acggacccaa aaatgctaag caaaaaaagg actacttcta gccaatggca 300 gtctcctcct gttgtcgtta tcttgaagga tatggaaagc tttgccacaa aagtactaca 360 agacttcata attatcagca gtcaacatct ccatgaattt ccactaatac tcatttttgg 420 aatagccaca tctcctatta tcatccaccg attgcttcct catgcagtat catctctatt 480 gtgcatagaa ctgttccaat ctttgtcttg taaggagcac ctgactacgg tactcgataa 540 gctacttctt acaactcagt ttccctttaa aataaatgaa aaagtattac aggttctgac 600 caacatcttt ttgtatcatg atttctcagt tcaaaacttt ataaaaggac ttcagctttc 660 tctattagag catttctatt cccagccctt aagtgtcctg tgctgtaatc ttccagaagc 720 caaaagaaga ataaattttt tatcaaataa tcaatgtgaa aacatccgac gtctaccatc 780 ttttaggagg tacgtggaaa agcaagcttc agaaaagcaa gttgcgctct tgaccaatga 840 gagatatttg aaggaggaaa cacaattatt actagaaaac ctgcatgttt atcatatgaa 900 ttacttcctg gttttgagat gtcttcataa gttcacctct tctcttccca agtatccact 960 aggtcgacag atcagagagt tgtactgtac atgtttagaa aagaacatat gggattcaga 1020 ggagtatgca tcagtcttgc agctgctgag gatgttggca aaggatgaac tgatgaccat 1080 acttgagaaa tgtttcaagg tttttaagtc ttattgtgaa aaccaccttg gcagcacagc 1140 taagagaata gaggagttcc tggcccagtt tcagagcctc gatgaaacca aagaagaaga 1200 agatgcttct gggtcacagc caaaggggct tcagaagaca gacctctatc atcttcagaa 1260 gtccttattg gaaatgaagg agtttagaag aagttagaag caaaccaaat ttgaagtact 1320 cagagaaaat gttgtgaact tcattgactg tctagtgaga gaataccttc tgcctcctga 1380 gacacagcct ctccatgagg tggtgtactt cagtgctgcc catgcccttc gtgagcattt 1440 aaatgctgct ccgcgaattg ccctccatac tgcactcaac aatccttact attatctcaa 1500 gaatgaagca ctgaaaagcg aagaaggctg cattccgaat atcgccccag acatctgcat 1560 agcatacaaa ctgcacctag agtgtagcag gctcatcaac ctcgtggact ggtcagaggc 1620 ttttgcaaca gttgtgacag ctgctgaaaa aatggatgca aattctgcaa cctcagaaga 1680 aatgaatgaa attatccatg ctcggtttat tagagctgtt tctgaactag aacttttagg 1740 atttataaaa cctaccaaac agaagactga ccatgtggca agactaacat ggggaggctg 1800 ctagaaagca aataagcaaa gccagaacta tcacatttag cttaagagaa aaaggtgacc 1860 agtcatattt acatatatta gaggagcctg ttttgttgag aagataaatg tgtaaccccc 1920 attgatgttt aaccagaaaa gtacattgct aaccccaaac aggcatgtat caaaacacct 1980 gtggagtact ttagactcca acaaataata atgtaactaa aactgctcac acattttact 2040 gtactttcca aagtcattac taaattgtga gtaaatcatt cttgaactta gagtatgtaa 2100 atgtaataaa ttccgttatc caggagtata aaaaaaaaaa aaaaaaaaaa aa 2152 <210> 22 <211> 1886 <212> DNA <213> Homo sapiens <400> 22 aattattgta gaaagaggaa gataaagttt tatactttta aaaaaaccct gtggaaattt 60 actatttggt ctacccttaa caattgccat atttagtggt tgtctacttt ttgttgttgt 120 tgttggggtt taaattttag ttcaagtaac cagttcaatt tctcagtaat catagtctac 180 ttagctttgt ttctttctcc caagttagca atattagtat ttctcctcat ttttttatta 240 tgaaagatgt caaatataag tgaattagtt gtattacaaa atgcccacat tctggatttg 300 tctgttactt catggttaat attagaactt tttttttttt tttgagactg agtctcactc 360 tgttgcccag gctggagtgc agtgtcgtga tctcagctcg ctgcaacctc cgactccccg 420 gttccagcga ttctcctgcc tcagcctccc gagtagctgg gactacaggc gcccaccact 480 acacccggct aattttttat aattttagta gagacgaggt ttcaccgtgg tagccaggat 540 ggtcttgatc tcctgacctc gtggtccacc cgcctcggcc tcccaaagtg ctgggattac 600 aggtgtgagc caccgtgcct ggaaatatta gaacttttaa tcatcatagt tttaatgact 660 tagatgcatt tgctgagaat aatttgaata tttgtgtaat gccactgctt aaaaattcct 720 aatattggtc tgattccttt tgatgccatt actgagtatg atcttagtgg agaaatcctg 780 taaactccaa gaacaagatc ctaactttag aatatctgta ttttctctcc atttctaaca 840 aagatttctt ctatagctgt gaatgagcta ctcaaccact ctgcctgtgc tataaataac 900 aattagatct gcctacttca tttaaagttc agtgggttta ctgactgatg tttataaagc 960 ccataggaga tgtaaagcat agtttaaatg gtgataatta gagaaatgag tgtactattt 1020 tggttctttc aaacaagttt acatttagca cgtcatatct tctgtagaca tttcttattt 1080 catatgtacg tttagatcaa aagaaaggaa aactatcatt aaatgcctac tgtgtggtaa 1140 gcactgtgct agagtcttcc attgcttctt ctcatttaat ttttaagtct ccatctaacc 1200 tgtgaaataa gcaagttatt atttccattt tacagacaac gaaccaagga tcagagatgt 1260 ataataacct tattctttat tacaaacatc atgttagagc cacactatga atccagacct 1320 ttgtaaattt tctaagctaa actttatcat gagaaccctt caagaattct tctgaatgtc 1380 acatatatgg aggaaaatct ctccaaaaaa tgttggtagc tactaatgaa gaaatgaatg 1440 aaattatcca cctccagtgc tcggtttatt agagctgttt ctgaactaga acttttagga 1500 tttataaaac ctaccaaaca gaagactgac catgtggcaa gactaacatg gggaggctgc 1560 tagaaagcaa ataagcaaag ccagaactat cacatttagc ttaagagaaa aaggtgacca 1620 gtcatattta catatattag aggagcctgt tttgttgaga agataaatgt gtaaccccca 1680 ttgatgttta accagaaaag tacattgcta accccaaaca ggcatgtatc aaaacacctg 1740 tggagtactt tagactccaa caaataataa tgtaactaaa actgctcaca cattttactg 1800 tactttccaa agtcattact aaattgtgag taaatcattc ttgaacttag agtatgtaaa 1860 tgtaataaat tccgttatcc aggagt 1886 <210> 23 <211> 2653 <212> DNA <213> Homo sapiens <400> 23 gagcgcggct ggagtttgct gctgccgctg tgcagtttgt tcaggggctt gtggtggtga 60 gtccgagagg ctgcgtgtga gagacgtgag aaggatcctg cactgaggag gtggaaagaa 120 gaggattgct cgaggaggcc tggggtctgt gaggcagcgg agctgggtga aggctgcggg 180 ttccggcgag gcctgagctg tgctgtcgtc atgcctcaaa cccgatccca ggcacaggct 240 acaatcagtt ttccaaaaag gaagctgtct cgggcattga acaaagctaa aaactccagt 300 gatgccaaac tagaaccaac aaatgtccaa accgtaacct gttctcctcg tgtaaaagcc 360 ctgcctctca gccccaggaa acgtctgggc gatgacaacc tatgcaacac tccccattta 420 cctccttgtt ctccaccaaa gcaaggcaag aaagagaatg gtccccctca ctcacataca 480 cttaagggac gaagattggt atttgacaat cagctgacaa ttaagtctcc tagcaaaaga 540 gaactagcca aagttcacca aaacaaaata ctttcttcag ttagaaaaag tcaagagatc 600 acaacaaatt ctgagcagag atgtccactg aagaaagaat ctgcatgtgt gagactattc 660 aagcaagaag gcacttgcta ccagcaagca aagctggtcc tgaacacagc tgtcccagat 720 cggctgcctg ccagggaaag ggagatggat gtcatcagga atttcttgag ggaacacatc 780 tgtgggaaaa aagctggaag cctttacctt tctggtgctc ctggaactgg aaaaactgcc 840 tgcttaagcc ggattctgca agacctcaag aaggaactga aaggctttaa aactatcatg 900 ctgaattgca tgtccttgag gactgcccag gctgtattcc cagctattgc tcaggagatt 960 tgtcaggaag aggtatccag gccagctggg aaggacatga tgaggaaatt ggaaaaacat 1020 atgactgcag agaagggccc catgattgtg ttggtattgg acgagatgga tcaactggac 1080 agcaaaggcc aggatgtatt gtacacgcta tttgaatggc catggctaag caattctcac 1140 ttggtgctga ttggtattgc taataccctg gatctcacag atagaattct acctaggctt 1200 caagctagag aaaaatgtaa gccacagctg ttgaacttcc caccttatac cagaaatcag 1260 atagtcacta ttttgcaaga tcgacttaat caggtatcta gagatcaggt tctggacaat 1320 gctgcagttc aattctgtgc ccgcaaagtc tctgctgttt caggagatgt tcgcaaagca 1380 ctggatgttt gcaggagagc tattgaaatt gtagagtcag atgtcaaaag ccagactatt 1440 ctcaaaccac tgtctgaatg taaatcacct tctgagcctc tgattcccaa gagggttggt 1500 cttattcaca tatcccaagt catctcagaa gttgatggta acaggatgac cttgagccaa 1560 gaaggagcac aagattcctt ccctcttcag cagaagatct tggtttgctc tttgatgctc 1620 ttgatcaggc agttgaaaat caaagaggtc actctgggga agttatatga agcctacagt 1680 aaagtctgtc gcaaacagca ggtggcggct gtggaccagt cagagtgttt gtcactttca 1740 gggctcttgg aagccagggg cattttagga ttaaagagaa acaaggaaac ccgtttgaca 1800 aaggtgtttt tcaagattga agagaaagaa atagaacatg ctctgaaaga taaagcttta 1860 attggaaata tcttagctac tggattgcct taaattcttc tcttacaccc cacccgaaag 1920 tattcagctg gcatttagag agctacagtc ttcattttag tgctttacac attcgggcct 1980 gaaaacaaat atgacctttt ttacttgaag ccaatgaatt ttaatctata gattctttaa 2040 tattagcaca gaataatatc tttgggtctt actattttta cccataaaag tgaccaggta 2100 gacccttttt aattacattc actacttcta ccacttgtgt atctctagcc aatgtgcttg 2160 caagtgtaca gatctgtgta gaggaatgtg tgtatattta cctcttcgtt tgctcaaaca 2220 tgagtgggta tttttttgtt tgtttttttt gttgttgttg tttttgaggc gcgtctcacc 2280 ctgttgccca ggctggagtg caatggcgcg ttctctgctc actacagcac ccgcttccca 2340 ggttgaagtg attctcttgc ctcagcctcc cgagtagctg ggattacagg tgcccaccac 2400 cgcgcccagc taatttttta atttttagta gagacagggt tttaccatgt tggccaggct 2460 ggtcttgaac tcctgaccct caagtgatct gcccaccttg gcctccctaa gtgctgggat 2520 tataggcgtg agccaccatg ctcagccatt aaggtatttt gttaagaact ttaagtttag 2580 ggtaagaaga atgaaaatga tccagaaaaa tgcaagcaag tccacatgga gatttggagg 2640 acactggtta aag 2653 <210> 24 <211> 2021 <212> DNA <213> Homo sapiens <220> <221> misc_feature <222> (1886)..(1886) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (1896)..(1896) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (1928)..(1928) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (1934)..(1934) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (1973)..(1973) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (2010)..(2010) <223> "n" means any of A, T, G, and C. <400> 24 gaattccggg gaggcctggg gtctgtgagg cagcggagct gggtgaaggc tgcgggttcc 60 ggcgaggcct gagctgtgct gtcgtcatgc ctcaaacccg atcccaggca caggctacaa 120 tcagttttcc aaaaaggaag ctgtctcggg cattgaacaa agctaaaaac tccagtgatg 180 ccaaactaga accaacaaat gtccaaaccg taacctgttc tcctcgtgta aaagccctgc 240 ctctcagccc caggaaacgt ctgggcgatg acaacctatg caacactccc catttacctc 300 cttgttctcc accaaagcaa ggcaagaaag agaatggtcc ccctcactca catacactta 360 agggacgaag attggtattt gacaatcagc tgacaattaa gtctcctagc aaaagagaac 420 tagccaaagt tcaccaaaac aaaatacttt cttcagttag aaaaagtcaa gagatcacaa 480 caaattctga gcagagatgt ccactgaaga aagaatctgc atgtgtgaga ctattcaagc 540 aagaaggcac ttgctaccag caagcaaagc tggtcctgaa cacagctgtc ccagatcggc 600 tgcctgccag ggaaagggag atggatgtca tcaggaattt cttgagggaa cacatctgtg 660 ggaaaaaagc tggaagcctt tacctttctg gtgctcctgg aactggaaaa actgcctgct 720 taagccggat tctgcaagac ctcaagaagg aactgaaagg ctttaaaact atcatgctga 780 attgcatgtc cttgaggact gcccaggctg tattcccagc tattgctcag gagatttgtc 840 aggaagaggt atccaggcca gctgggaagg acatgatgag gaaattggaa aaacatatga 900 ctgcagagaa gggccccatg attgtgttgg tattggacga gatggatcaa ctggacagca 960 aaggccagga tgtattgtac acgctatttg aatggccatg gctaagcaat tctcacttgg 1020 tgctgattgg tattgctaat accctggatc tcacagatag aattctacct aggcttcaag 1080 ctagagaaaa atgtaagcca cagctgttga acttcccacc ttataccaga aatcagatag 1140 tcactatttt gcaagatcga cttaatcagg tatctagaga tcaggttctg gacaatgctg 1200 cagttcaatt ctgtgcccgc aaagtctctg ctgtttcagg agatgttcgc aaagcactgg 1260 atgtttgcag gagagctatt gaaattgtag agtcagatgt caaaagccag actattctca 1320 aaccactgtc tgaatgtaaa tcaccttctg agcctctgat tcccaagagg gttggtctta 1380 ttcacatatc ccaagtcatc tcagaagttg atggtaacag gatgaccttg agccaagaag 1440 gagcacaaga ttccttccct cttcagcaga agatcttggt ttgctctttg atgctcttga 1500 tcaggcagtt gaaaatcaaa gaggtcactc tggggaagtt atatgaagcc tacagtaaag 1560 tctgtcgcaa acagcaggtg gcggctgtgg accagtcaga gtgtttgtca ctttcagggc 1620 tcttggaagc caggggcatt ttaggattaa agagaaacaa ggaaacccgt ttgacaaagg 1680 tgtttttcaa gattgaagag aaagaaatag aacatgctct gaaagataaa gctttaattg 1740 gaaatatctt agctactgga ttgccttaaa ttcttctctt acaccccacc cgaaagtatt 1800 cagctgggca tttagagagc tacagtcttc attttagtgc tttacacatt cgggcctgaa 1860 aacaaatatg acctttttta cttganggcc aatggnattt taatctatag gattctttta 1920 atattagnca cagnaattaa tatctttggg ggtctttact tatttttacc ccnttaaaaa 1980 gtgaccgggg taggacccct tttttaattn ccatttcact a 2021 <210> 25 <211> 2861 <212> DNA <213> Homo sapiens <400> 25 ctgccgctgt gcagtttgtt caggggcttg tggtggtgag tccgagaggc tgcgtgtgag 60 agacgtgaga aggatcctgc actgaggagg tggaaagaag aggattgctc gaggaggcct 120 ggggtctgtg aggcagcgga gctgggtgaa ggctgcgggt tccggcgagg cctgagctgt 180 gctgtcgtca tgcctcaaac ccgatcccag gcacaggcta caatcagttt tccaaaaagg 240 aagctgtctc gggcattgaa caaagctaaa aactccagtg atgccaaact agaaccaaca 300 aatgtccaaa ccgtaacctg ttctcctcgt gtaaaagccc tgcctctcag ccccaggaaa 360 cgtctgggcg atgacaacct atgcaacact ccccatttac ctccttgttc tccaccaaag 420 caaggcaaga aagagaatgg tccccctcac tcacatacac ttaagggacg aagattggta 480 tttgacaatc agctgacaat taagtctcct agcaaaagag aactagccaa agttcaccaa 540 aacaaaatac tttcttcagt tagaaaaagt caagagatca caacaaattc tgagcagaga 600 tgtccactga agaaagaatc tgcatgtgtg agactattca agcaagaagg cacttgctac 660 cagcaagcaa agctggtcct gaacacagct gtcccagatc ggctgcctgc cagggaaagg 720 gagatggatg tcatcaggaa tttcttgagg gaacacatct gtgggaaaaa agctggaagc 780 ctttaccttt ctggtgctcc tggaactgga aaaactgcct gcttaagccg gattctgcaa 840 gacctcaaga aggaactgaa aggctttaaa actatcatgc tgaattgcat gtccttgagg 900 actgcccagg ctgtattccc agctattgct caggagattt gtcaggaaga ggtatccagg 960 ccagctggga aggacatgat gaggaaattg gaaaaacata tgactgcaga gaagggcccc 1020 atgattgtgt tggtattgga cgagatggat caactggaca gcaaaggcca ggatgtattg 1080 tacacgctat ttgaatggcc atggctaagc aattctcact tggtgctgat tggtattgct 1140 aataccctgg atctcacaga tagaattcta cctaggcttc aagctagaga aaaatgtaag 1200 ccacagctgt tgaacttccc accttatacc agaaatcaga tagtcactat tttgcaagat 1260 cgacttaatc aggtatctag agatcaggtt ctggacaatg ctgcagttca attctgtgcc 1320 cgcaaagtct ctgctgtttc aggagatgtt cgcaaagcac tggatgtttg caggagagct 1380 attgaaattg tagagtcaga tgtcaaaagc cagactattc tcaaaccact gtctgaatgt 1440 aaatcacctt ctgagcctct gattcccaag agggttggtc ttattcacat atcccaagtc 1500 atctcagaaa ttgatggtaa caggatgacc ttgagccaag aaggagcaca agattccttc 1560 cctcttcagc agaagatctt ggtttgctct ttgatgctct tgatcaggca gttgaaaatc 1620 aaagaggtca ctctggggaa gttatatgaa gcctacagta aagtctgtcg caaacagcag 1680 gtggcggctg tggaccagtc agagtgtttg tcactttcag ggctcttgga agccaggggc 1740 attttaggat taaagagaaa caaggaaacc cgtttgacaa aggtgttttt caagattgaa 1800 gagaaagaaa tagaacatgc tctgaaagat aaagctttaa ttggaaatat cttagctact 1860 ggattgcctt aaattcttct cttacacccc acccgaaagt attcagctgg catttagaga 1920 gctacagtct tcattttagt gctttacaca ttcgggcctg aaaacaaata tgaccttttt 1980 tacttgaagc caatgaattt taatctatag attctttaat attagcacag aataatatct 2040 ttgggtctta ctatttttac ccataaaagt gaccaggtag acccttttta attacattca 2100 ctacttctac cacttgtgta tctctagcca atgtgcttgc aagtgtacag atctgtgtag 2160 aggaatgtgt gtatatttac ctcttcgttt gctcaaacat gagtgggtat ttttttgttt 2220 gttttttttg ttgttgttgt ttttgaggcg cgtctcaccc tgttgcccag gctggagtgc 2280 aatggcgcgt tctctgctca ctacagcacc cgcttcccag gttgaagtga ttctcttgcc 2340 tcagcctccc gagtagctgg gattacaggt gcccaccacc gcgcccagct aattttttaa 2400 tttttagtag agacagggtt ttaccatgtt ggccaggctg gtcttgaact cctgaccctc 2460 aagtgatctg cccaccttgg cctccctaag tgctgggatt ataggcgtga gccaccatgc 2520 tcagccatta aggtattttg ttaagaactt taagtttagg gtaagaagaa tgaaaatgat 2580 ccagaaaaat gcaagcaagt ccacatggag atttggagga cactggttaa agaatttatt 2640 tctttgtata gtatactatg ttcatggtgc agatactaca acattgtggc attttagact 2700 cgttgagttt cttgggcact cccaagggcg ttggggtcat aaggagacta taactctaca 2760 gattgtgaat atatttattt tcaagttgca ttctttgtct ttttaagcaa tcagatttca 2820 agagagctca agctttcaga aaaaaaaaaa aaaaaaaaaa a 2861 <210> 26 <211> 2653 <212> DNA <213> Homo sapiens <400> 26 gagcgcggct ggagtttgct gctgccgctg tgcagtttgt tcaggggctt gtggcggtga 60 gtccgagagg ctgcgtgtga gagacgtgag aaggatcctg cactgaggag gtggaaagaa 120 gaggattgct cgaggaggcc tggggtctgt gagacagcgg agctgggtga aggctgcggg 180 ttccggcgag gcctgagctg tgctgtcgtc atgcctcaaa cccgatccca ggcacaggct 240 acaatcagtt ttccaaaaag gaagctgtct cgggcattga acaaagctaa aaactccagt 300 gatgccaaac tagaaccaac aaatgtccaa accgtaacct gttctcctcg tgtaaaagcc 360 ctgcctctca gccccaggaa acgtctgggc gatgacaacc tatgcaacac tccccattta 420 cctccttgtt ctccaccaaa gcaaggcaag aaagagaatg gtccccctca ctcacataca 480 cttaagggac gaagattggt atttgacaat cagctgacaa ttaagtctcc tagcaaaaga 540 gaactagcca aagttcacca aaacaaaata ctttcttcag ttagaaaaag tcaagagatc 600 acaacaaatt ctgagcagag atgtccactg aagaaagaat ctgcatgtgt gagactattc 660 aagcaagaag gcacttgcta ccagcaagca aagctggtcc tgaacacagc tgtcccagat 720 cggctgcctg ccagggaaag ggagatggat gtcatcagga atttcttgag ggaacacatc 780 tgtgggaaaa aagctggaag cctttacctt tctggtgctc ctggaactgg aaaaactgcc 840 tgcttaagcc ggattctgca agacctcaag aaggaactga aaggctttaa aactatcatg 900 ctgaattgca tgtccttgag gactgcccag gctgtattcc cagctattgc tcaggagatt 960 tgtcaggaag aggtatccag gccagctggg aaggacatga tgaggaaatt ggaaaaacat 1020 atgactgcag agaagggccc catgattgtg ttggtattgg acgagatgga tcaactggac 1080 agcaaaggcc aggatgtatt gtacacgcta tttgaatggc catggctaag caattctcac 1140 ttggtgctga ttggtattgc taataccctg gatctcacag atagaattct acctaggctt 1200 caagctagag aaaaatgtaa gccacagctg ttgaacttcc caccttatac cagaaatcag 1260 atagtcacta ttttgcaaga tcgacttaat caggtatcta gagatcaggt tctggacaat 1320 gctgcagttc aattctgtgc ccgcaaagtc tctgctgttt caggagatgt tcgcaaagca 1380 ctggatgttt gcaggagagc tattgaaatt gtagagtcag atgtcaaaag ccagactatt 1440 ctcaaaccac tgtctgaatg taaatcacct tctgagcctc tgattcccaa gagggttggt 1500 cttattcaca tatcccaagt catctcagaa gttgatggta acaggatgac cttgagccaa 1560 gagggagcac aagattcctt ccctcttcag cagaagatct tggtttgctc tttgatgctc 1620 ttgatcaggc agttgaaaat caaagaggtc actctgggga agttatatga agcctacagt 1680 aaagtctgtc gcaaacagca ggtggcggct gtggaccagt cagagtgttt gtcactttca 1740 gggctcttgg aagccagggg cattttagga ttaaagagaa acaaggaaac ccgtttgaca 1800 aaggtgtttt tcaagattga agagaaagaa atagaacatg ctctgaaaga taaagcttta 1860 attggaaata tcttagctac tggattgcct taaattcttc tcttacaccc cacccgaaag 1920 tattcagctg gcatttagag agctacagtc ttcattttag tgctttacac attcgggcct 1980 gaaaacaaat atgacctttt ttacttgaag ccaatgaatt ttaatctata gattctttaa 2040 tattagcaca gaataatatc tttgggtctt actattttta cccataaaag tgaccaggta 2100 gacccttttt aattacattc actacttcta ccacttgtgt atctctagcc aatgtgcttg 2160 caagtgtaca gatctgtgta gaggaatgtg tgtatattta cctcttcgtt tgctcaaaca 2220 tgagtgggta tttttttgtt tgtttttttt gttgttgttg tttttgaggc gcgtctcacc 2280 ctgttgccca ggctggagtg caatggcgcg ttctctgctc actacagcac ccgcttccca 2340 ggttgaagtg attctcttgc ctcagcctcc cgagtagctg ggattacagg tgcccaccac 2400 cgcgcccagc taatttttta atttttagta gagacagggt tttaccatgt tggccaggct 2460 ggtcttgaac tcctgaccct caagtgatct gcccaccttg gcctccctaa gtgctgggat 2520 tataggcgtg agccaccatg ctcagccatt aaggtatttt gttaagaact ttaagtttag 2580 ggtaagaaga atgaaaatga tccagaaaaa tgcaagcaag tccacatgga gatttggagg 2640 acactggtta aag 2653 <210> 27 <211> 2742 <212> DNA <213> Homo sapiens <400> 27 cccgcctctt cctcccttcc ttctttcctt gctttcgccg cgcactccgc cgccatggag 60 cagcgccgcg tcaccgactt cttcgcgcgc cgccgccccg ggcccccccg catcgcgccg 120 cccaagctgg cctgccgcac ccccagcccc gccaggcccg cactccgcgc cccggcctcc 180 gctaccagtg gcagccgcaa gcgcgcccgc ccgcccgccg cccccggacg cgaccaggcc 240 aggccaccgg cccgcaggag actgcggctg tcggtggacg aggtttccag ccccagtacc 300 cccgaggccc cagacatccc agcctgccct tctccgggcc agaagataaa gaaatccacc 360 ccggcagcag gtcagccgcc ccacctgaca tccgcgcagg accaggacac catctctgag 420 cttgcgtcat gcctgcaacg ggcccgggag ctgggggcaa gagtccgggc gctgaaggcc 480 agtgcccagg atgctgggga gtcctgcacc ccagaggccg agggccgccc tgaggagcca 540 tgtggcgaga aggcgcccgc ctaccagcgc ttccatgccc tggcccagcc cggcctgccg 600 ggactcgtgc tgccctacaa gtaccaggtg ctggcggaga tgttccgcag catggacacc 660 atcgtgggca tgctccacaa ccgctccgag acgcccacct ttgccaaggt ccagcggggc 720 gtccaggaca tgatgcgtag gcgttttgag gagcgcaatg ttggccagat caaaaccgtg 780 tacccggcct cctaccgctt ccgccaggag cgcagtgtcc ccaccttcaa ggatggcgcc 840 aggaggtcag attaccagct caccatcgag ccactgctgg agcaggaggc tgacggagca 900 gccccccagc tcacggcctc gcgcctcctg cagcgacggc agatcttcag ccagaagctg 960 gtggagcacg tcaaggagca ccacaaggcc ttcctggcct ccctgagccc cgccatggtg 1020 gtgccggagg accagctgac ccgctggcac ccgcgcttca acgtggatga agtacccgac 1080 atcgagccgg ccgcgctgcc ccagccaccc gccacggaga agctcaccac tgctcaggag 1140 gtgctggccc gggcccgcaa cctgatttca cccaggatgg agaaggcctt gagtcaattg 1200 gccctgcgct ctgctgcgcc cagcagcccc gggtctccca ggccagcact gccggctacc 1260 ccaccagcca ccccgcctgc agcctctccc agtgctctga agggggtgtc ccaggatctg 1320 ctggagcgga tccgagccaa ggaggcacag aagcagctgg cacagatgac gcggtgcccg 1380 gagcaggagc agcggctgca gcgcttagaa cggctgcctg agctggcccg cgtgctgcgg 1440 agcgtctttg tgtccgaacg caagcctgcg ctcagcatgg aggtggcctg tgccaggatg 1500 gtgggcagct gttgtactat catgagccct ggggaaatgg agaagcacct gctgctcctc 1560 tccgagctgc tgccggactg gctcagcctc caccgcatcc gcaccgacac ctacgtcaag 1620 ctggacaagg ccgcggacct ggcccacatc actgcacgcc tggcccacca gacacgtgct 1680 gaggaggggc tgtgagcctg ggggccactg tggacagacg tgggcttcag aagctcgctg 1740 gcctgggccc accagcattt tcttttatga acatgataca ctttggcctt cctttcccca 1800 gcgcccctga gggccagagg cagatgtggg ctgcaggctg cacagcccga gggtctctgg 1860 ctgcgggcgg tgggcccctt catggggctc acctggtgga ttcacattaa accggtttct 1920 gtgggcacct ttgtccttgc tgctggtggg gaagggaagc cagatccagc accccctggg 1980 gggccatcgg gagtgtggct gggggtgaag ggggctctgt ggcaatatgg ggttgggtag 2040 tgtgggtggc aggccatccc ctctaatctt ggaacctctg aatatgggac ctcccacagc 2100 aaagggtgac ttttgtcatt aagaaagact ggggtgggtg tggtggctca cgcctgtaac 2160 cccagcactt tgggaggcca aggtgggcag atcacgaggt caagagatcg agaccatcct 2220 ggcgaacatg gtgaaacccc atctctacta aaaatacaaa aaattagccg ggtgtggtgg 2280 tgggcacctg tcgtcccagc tactagggag gctgaggcag gagaatggtg tgaacccagg 2340 aggcacagct tgcagtgagc gaagatcgca ccactgcacg cactccagcc tgggtgacag 2400 agcgagactc cgtctcaaaa aaaaaaattt caagactgga gaggtgatcc tgaattgtcc 2460 agctacgccc catgtcatca cagggccttc atgacagggc cagagccagc cagctttgaa 2520 gacgcggccc tgccccgaca caggcagcct ggagaagctg ggcaggacaa gtaggacatc 2580 cctggagcct ccagaaggga ctggcctctg cccacacctt gacttcagta tttctgacct 2640 cctaaactct aataaagtca tgcttacagc cactaaaaaa aaaaaaaaaa aaaaaaaaaa 2700 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa 2742 <210> 28 <211> 1805 <212> DNA <213> Homo sapiens <400> 28 ctccgcgccc cggcctccgc taccagtggc agccgcaagc gcgcccgccc gcccgccgcc 60 cccggacgcg accaggccag gccaccggcc cgcaggagac tgcggctgtc ggtggacgag 120 gtttccagcc ccagtacccc cgaggcccca gacatcccag cctgcccttc tccgggccag 180 aagataaaga aatccacccc ggcagcaggt cagccgcccc acctgacatc cgcgcaggac 240 caggacacca tctctgagct tgcgtcatgc ctgcaacggg cccgggagct gggggcaaga 300 gtccgggcgc tgaaggccag tgcccaggat gctggggagt cctgcacccc agaggccgag 360 ggccgccctg aggagccatg tggcgagaag gcgcccgcct accagcgctt ccatgccctg 420 gcccagcccg gcctgccggg actcgtgctg ccctacaagt accaggtgct ggcggagatg 480 ttccgcagca tggacaccat cgtgggcatg ctccacaacc gctccgagac gcccaccttt 540 gccaaggtcc agcggggcgt ccaggacatg atgcgtaggc gttttgagga gcgcaatgtt 600 ggccagatca aaaccgtgta cccggcctcc taccgcttcc gccaggagcg cagtgtcccc 660 accttcaagg atggcgccag gaggtcagat taccagctca ccatcgagcc actgctggag 720 caggaggctg acggagcagc cccccagctc acggcctcgc gcctcctgca gcgacggcag 780 atcttcagcc agaagctggt ggagcacgtc aaggagcacc acaaggcctt cctggcctcc 840 ctgagccccg ccatggtggt gccggaggac cagctgaccc gctggcaccc gcgcttcaac 900 gtggatgaag tacccgacat cgagccggcc gcgctgcccc agccacccgc cacggagaag 960 ctcaccactg ctcaggaggt gctggcccgg gcccgcaacc tgatttcacc caggatggag 1020 aaggccttga gtcaattggc cctgcgctct gctgcgccca gcagccccgg gtctcccagg 1080 ccagcactgc cggctacccc accagccacc ccgcctgcag cctctcccag tgctctgaag 1140 ggggtgtccc aggatctgct ggagcggatc cgagccaagg aggcacagaa gcagctggca 1200 cagatgacgc ggtgcccgga gcaggagcag cggctgcagc gcttagaacg gctgcctgag 1260 ctggcccgcg tgctgcggag cgtctttgtg tccgaacgca agcctgcgct cagcatggag 1320 gtggcctgtg ccaggatggt gggcagctgt tgtactatca tgagccctgg ggaaatggag 1380 aagcacctgc tgctcctctc cgagctgctg ccggactggc tcagcctcca ccgcatccgc 1440 accgacacct acgtcaagct ggacaaggcc gcggacctgg cccacatcac tgcacgcctg 1500 gcccaccaga cacgtgctga ggaggggctg tgagcctggg ggccactgtg gacagacgtg 1560 ggcttcagaa gctcgctggc ctgggcccac cagcattttc ttttatgaac atgatacact 1620 ttggtcttcc tttccccagc gcccctgagg gccagaggca gatgtgggct gcaggctgca 1680 cagcccgagg gtctctggct gcgggcggtg ggccccttca tggggctcac ctggtggatt 1740 cacattaaac cggtttctgt gggcaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1800 aaaaa 1805 <210> 29 <211> 1924 <212> DNA <213> Homo sapiens <400> 29 acgcgtccgc gcgcactccg ccgccatgga gcagcgccgc gtcaccgact tcttcgcgcg 60 ccgccgcccc gggccccccc gcatcgcgcc gcccaagctg gcctgccgca cccccagccc 120 cgccaggccc gcactccgcg ccccggcctc cgctaccagt ggcagccgca agcgcgcccg 180 cccgcccgcc gcccccggac gcgaccaggc caggccaccg gcccgcagga gactgcggct 240 gtcggtggac gaggtttcca gccccagtac ccccgaggcc ccagacatcc cagcctgccc 300 ttctccgggc cagaagataa agaaatccac cccggcagca ggtcagccgc cccacctgac 360 atccgcgcag gaccaggaca ccatctctga gcttgcgtca tgcctgcaac gggcccggga 420 gctgggggca agagtccggg cgctgaaggc cagtgcccag gatgctgggg agtcctgcac 480 cccagaggcc gagggccgcc ctgaggagcc atgtggcgag aaggcgcccg cctaccagcg 540 cttccatgcc ctggcccagc ccggcctgcc gggactcgtg ctgccctaca agtaccaggt 600 gctggcggag atgttccgca gcatggacac catcgtgggc atgctccaca accgctccga 660 gacgcccacc tttgccaagg tccagcgggg cgtccaggac atgatgcgta ggcgttttga 720 ggagcgcaat gttggccaga tcaaaaccgt gtacccggcc tcctaccgct tccgccagga 780 gcgcagtgtc cccaccttca aggatggcgc caggaggtca gattaccagc tcaccatcga 840 gccactgctg gagcaggagg ctgacggagc agccccccag ctcacggcct cgcgcctcct 900 gcagcgacgg cagatcttca gccagaagct ggtggagcac gtcaaggagc accacaaggc 960 cttcctggcc tccctgagcc ccgccatggt ggtgccggag gaccagctga cccgctggca 1020 cccgcgcttc aacgtggatg aagtacccga catcgagccg gccgcgctgc cccagccacc 1080 cgccacggag aagctcacca ctgctcagga ggtgctggcc cgggcccgca acctgatttc 1140 acccaggatg gagaaggcct tgagtcaatt ggccctgcgc tctgctgcgc ccagcagccc 1200 cgggtctccc aggccagcac tgccggctac cccaccagcc accccgcctg cagcctctcc 1260 cagtgctctg aagggggtgt cccaggatct gctggagcgg atccgagcca aggaggcaca 1320 gaagcagctg gcacagatga cgcggtgccc ggagcaggag cagcggctgc agcgcttaga 1380 acggctgcct gagctggccc gcgtgctgcg gagcgtcttt gtgtccgaac gcaagcctgc 1440 gctcagcatg gaggtggcct gtgccaggat ggtgggcagc tgttgtacta tcatgagccc 1500 tggggaaatg gagaagcacc tgctgctcct ctccgagctg ctgccggact ggctcagcct 1560 ccaccgcatc cgcaccgaca cctacgtcaa gctggacaag gccgcggacc tggcccacat 1620 cactgcacgc ctggcccacc agacacgtgc tgaggagggg ctgtgagcct gggggccact 1680 gtggacagac gtgggcttca gaagctcgct ggcctgggcc caccagcatt ttcttttatg 1740 aacatgatac actttggtct tcctttcccc agcgcccctg agggccagag gcagatgtgg 1800 gctgcaggct gcacagcccg agggtctctg gctgcgggcg gtgggcccct tcatggggct 1860 cacctggtgg attcacatta aaccggtttc tgtgggcaaa aaaaaaaaaa aaaaaaaaaa 1920 aaaa 1924 <210> 30 <211> 2742 <212> DNA <213> Homo sapiens <400> 30 cccgcctctt cctcccttcc ttctttcctt gctttcgccg cgcactccgc cgccatggag 60 cagcgccgcg tcaccgactt cttcgcgcgc cgccgccccg ggcccccccg catcgcgccg 120 cccaagctgg cctgccgcac ccccagcccc gccaggcccg cactccgcgc cccggcctcc 180 gctaccagtg gcagccgcaa gcgcgcccgc ccgcccgccg cccccggacg cgaccaggcc 240 aggccaccgg cccgcaggag actgcggctg tcggtggacg aggtttccag ccccagtacc 300 cccgaggccc cagacatccc agcctgccct tctccgggcc agaagataaa gaaatccacc 360 ccggcagcag gtcagccgcc ccacctgaca tccgcgcagg accaggacac catctctgag 420 cttgcgtcat gcctgcaacg ggcccgggag ctgggggcaa gagtccgggc gctgaaggcc 480 agtgcccagg atgctgggga gtcctgcacc ccagaggccg agggccgccc tgaggagcca 540 tgtggcgaga aggcgcccgc ctaccagcgc ttccatgccc tggcccagcc cggcctgccg 600 ggactcgtgc tgccctacaa gtaccaggtg ctggcggaga tgttccgcag catggacacc 660 atcgtgggca tgctccacaa ccgctccgag acgcccacct ttgccaaggt ccagcggggc 720 gtccaggaca tgatgcgtag gcgttttgag gagcgcaatg ttggccagat caaaaccgtg 780 tacccggcct cctaccgctt ccgccaggag cgcagtgtcc ccaccttcaa ggatggcgcc 840 aggaggtcag attaccagct caccatcgag ccactgctgg agcaggaggc tgacggagca 900 gccccccagc tcacggcctc gcgcctcctg cagcgacggc agatcttcag ccagaagctg 960 gtggagcacg tcaaggagca ccacaaggcc ttcctggcct ccctgagccc cgccatggtg 1020 gtgccggagg accagctgac ccgctggcac ccgcgcttca acgtggatga agtacccgac 1080 atcgagccgg ccgcgctgcc ccagccaccc gccacggaga agctcaccac tgctcaggag 1140 gtgctggccc gggcccgcaa cctgatttca cccaggatgg agaaggcctt gagtcaattg 1200 gccctgcgct ctgctgcgcc cagcagcccc gggtctccca ggccagcact gccggctacc 1260 ccaccagcca ccccgcctgc agcctctccc agtgctctga agggggtgtc ccaggatctg 1320 ctggagcgga tccgagccaa ggaggcacag aagcagctgg cacagatgac gcggtgcccg 1380 gagcaggagc agcggctgca gcgcttagaa cggctgcctg agctggcccg cgtgctgcgg 1440 agcgtctttg tgtccgaacg caagcctgcg ctcagcatgg aggtggcctg tgccaggatg 1500 gtgggcagct gttgtactat catgagccct ggggaaatgg agaagcacct gctgctcctc 1560 tccgagctgc tgccggactg gctcagcctc caccgcatcc gcaccgacac ctacgtcaag 1620 ctggacaagg ccgcggacct ggcccacatc actgcacgcc tggcccacca gacacgtgct 1680 gaggaggggc tgtgagcctg ggggccactg tggacagacg tgggcttcag aagctcgctg 1740 gcctgggccc accagcattt tcttttatga acatgataca ctttggcctt cctttcccca 1800 gcgcccctga gggccagagg cagatgtggg ctgcaggctg cacagcccga gggtctctgg 1860 ctgcgggcgg tgggcccctt catggggctc acctggtgga ttcacattaa accggtttct 1920 gtgggcacct ttgtccttgc tgctggtggg gaagggaagc cagatccagc accccctggg 1980 gggccatcgg gagtgtggct gggggtgaag ggggctctgt ggcaatatgg ggttgggtag 2040 tgtgggtggc aggccatccc ctctaatctt ggaacctctg aatatgggac ctcccacagc 2100 aaagggtgac ttttgtcatt aagaaagact ggggtgggtg tggtggctca cgcctgtaac 2160 cccagcactt tgggaggcca aggtgggcag atcacgaggt caagagatcg agaccatcct 2220 ggcgaacatg gtgaaacccc atctctacta aaaatacaaa aaattagccg ggtgtggtgg 2280 tgggcacctg tcgtcccagc tactagggag gctgaggcag gagaatggtg tgaacccagg 2340 aggcacagct tgcagtgagc gaagatcgca ccactgcacg cactccagcc tgggtgacag 2400 agcgagactc cgtctcaaaa aaaaaaattt caagactgga gaggtgatcc tgaattgtcc 2460 agctacgccc catgtcatca cagggccttc atgacagggc cagagccagc cagctttgaa 2520 gacgcggccc tgccccgaca caggcagcct ggagaagctg ggcaggacaa gtaggacatc 2580 cctggagcct ccagaaggga ctggcctctg cccacacctt gacttcagta tttctgacct 2640 cctaaactct aataaagtca tgcttacagc cactaaaaaa aaaaaaaaaa aaaaaaaaaa 2700 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa 2742 <210> 31 <211> 2661 <212> DNA <213> Homo sapiens <400> 31 cgcgcactcc gccgccatgg agcagcgccg cgtcaccgac ttcttcgcgc gccgccgccc 60 cgggcccccc cgcatcgcgc cgcccaagct ggcctgccgc acccccagcc ccgccaggcc 120 cgcactccgc gccccggcct ccgctaccag tggcagccgc aagcgcgccc gcccgcccgc 180 cgcccccgga cgcgaccagg ccaggccacc ggcccgcagg agactgcggc tgtcggtgga 240 cgaggtttcc agccccagta cccccgaggc cccagacatc ccagcctgcc cttctccggg 300 ccagaagata aagaaatcca ccccggcagc aggtcagccg ccccacctga catccgcgca 360 ggaccaggac accatctctg agcttgcgtc atgcctgcaa cgggcccggg agctgggggc 420 aagagtccgg gcgctgaagg ccagtgccca ggatgctggg gagtcctgca ccccagaggc 480 cgagggccgc cctgaggagc catgtggcga gaaggcgccc gcctaccagc gcttccatgc 540 cctggcccag cccggcctgc cgggactcgt gctgccctac aagtaccagg tgctggcgga 600 gatgttccgc agcatggaca ccatcgtggg catgctccac aaccgctccg agacgcccac 660 ctttgccaag gtccagcggg gcgtccagga catgatgcgt aggcgttttg aggagcgcaa 720 tgttggccag atcaaaaccg tgtacccggc ctcctaccgc ttccgccagg agcgcagtgt 780 ccccaccttc aaggatggca ccaggaggtc agattaccag ctcaccatcg agccactgct 840 ggagcaggag gctgacggag cagcccccca gctcacggcc tcgcgcctcc tgcagcgacg 900 gcagatcttc agccagaagc tggtggagca cgtcaaggag caccacaagg ccttcctggc 960 ctccctgagc cccgccatgg tggtgccgga ggaccagctg acccgctggc acccgcgctt 1020 caacgtggat gaagtacccg acatcgagcc ggccgcgctg ccccagccac ccgccacgga 1080 gaagctcacc actgctcagg aggtgctggc ccgggcccgc aacctgattt cacccaggat 1140 ggagaaggcc ttgagtcaat tggccctgcg ctctgctgcg cccagcagcc ccgggtctcc 1200 caggccagca ctgccggcta ccccaccagc caccccgcct gcagcctctc ccagtgctct 1260 gaagggggtg tcccaggatc tgctggagcg gatccgagcc aaggaggcac agaagcagct 1320 ggcacagatg acgcggtgcc cggagcagga gcagcggctg cagcgcttag aacggctgcc 1380 tgagctggcc cgcgtgctgc ggagcgtctt tgtgtccgaa cgcaagcctg cgctcagcat 1440 ggaggtggcc tgtgccagga tggtgggcag ctgttgtact atcatgagcc ctggggaaat 1500 ggagaagcac ctgctgctcc tctccgagct gctgccggac tggctcagcc tccaccgcat 1560 ccgcaccgac acctacgtca agctggacaa ggccgcggac ctcgcccaca tcactgcacg 1620 cctggcccac cagacacgtg ctgaggaggg gctgtgagcc tgggggccac tgtggacaga 1680 cgtgggcttc agaagctcgc tggcctgggc ccaccagcat tttcttttat gaacatgata 1740 cactttggcc ttcctttccc cagcgcccct gagggccaga ggcagatgtg ggctgcaggc 1800 tgcacagccc gagggtctct ggctgcgggc ggtgggcccc ttcatggggc tcacctggtg 1860 gattcacatt aaaccggttt ctgtgggcac ctctgtcctt gctgctggtg gggaagggaa 1920 gccagatcca gcaccccctg gggggccatc gggagtgtgg ctgggggtga agggggctct 1980 gtggcaatat ggggttgggt agtgtgggtg gcaggccatc ccctctaatc ttggaacctc 2040 tgaatatggg acctcccaca gcaaagggtg acttttgtca ttaagaaaga ctggggtggg 2100 tgtggtggct cacgcctgta accccagcac tttgggaggc caaggtgggc agatcacgag 2160 gtcaagagat cgagaccatc ctggcgaaca tggtgaaacc ccatctctac taaaaataca 2220 aaaaattagc cgggtgtggt ggtgggcacc tgtcgtccca gctactaggg aggctgaggc 2280 aggagaatgg tgtgaaccca ggaggcacag cttgcagtga gcgaagatcg caccactgca 2340 cgcactccag cctgggtgac agagcgagac tccgtctcaa aaaaaaaaat ttcaagactg 2400 gagaggtgat cctgaattgt ccagctacgc cccatgtcat cacagggcct tcatgacagg 2460 gccagagcca gccagctttg aagacgcggc cctgccccga cacaggcagc ctggagaagc 2520 tgggcaggac aagtaggaca tccctggagc ctccagaagg gactggcctc tgcccacccc 2580 ttgacttcag tatttctgac ctcctaaact ctaataaagt catgcttaca gcccctaaaa 2640 aaaaaaaaaa aaaaaaaaaa a 2661 <210> 32 <211> 2589 <212> DNA <213> Homo sapiens <400> 32 ccgcatcgcg ccgcccaagc tggcctgccg cacccccagc cccgccaggc ccgcactccg 60 cgccccggcc tccgctacca gtggcagccg caagcgcgcc cgcccgcccg ccgcccccgg 120 acgcgaccag gccaggccac cggcccgcag gagactgcgg ctgtcggtgg acgaggtttc 180 cagccccagt acccccgagg ccccagacat cccagcctgc ccttctccgg gccagaagat 240 aaagaaatcc accccggcag caggtcagcc gccccacctg acatccgcgc aggaccagga 300 caccatctct gagcttgcgt catgcctgca acgggcccgg gagctggggg caagagtccg 360 ggcgctgaag gccagtgccc aggatgctgg ggagtcctgc accccagagg ccgagggccg 420 ccctgaggag ccatgtggcg agaaggcgcc cgcctaccag cgcttccatg ccctggccca 480 gcccggcctg ccggggctcg tgctgcccta caagtaccag gtgctggcgg agatgttccg 540 cagcatggac accatcgtgg gcatgctcca caaccgctcc gagacgccca cctttgccaa 600 ggtccagcgg ggcgtccagg acatgatgcg taggcgtttt gaggagcgca atgttggcca 660 gatcaaaacc gtgtacccgg cctcctaccg cttccgccag gagcgcagtg tccccacctt 720 caaggatggc gccaggaggt cagattacca gctcaccatc gagccactgc tggagcagga 780 ggctgacgga gcagcccccc agctcacggc ctcgcgcctc ctgcagcgac ggcagatctt 840 cagccagaag ctggtggagc acgtcaagga gcaccacaag gccttcctgg cctccctgag 900 ccccgccatg gtggtgccgg aggaccagct gacccgctgg cacccgcgct tcaacgtgga 960 tgaagtaccc gacatcgagc cggccgcgct gccccagcca cccgccacgg agaagctcac 1020 cactgctcag gaggtgctgg cccgggcccg caacctgatt tcacccagga tggagaaggc 1080 cttgagtcaa ttggccctgc gctctgctgc gcccagcagc cccgggtctc ccaggccagc 1140 actgccggct accccaccag ccaccccgcc tgcagcctct cccagtgctc tgaagggggt 1200 gtcccaggat ctgctggagc ggatccgagc caaggaggca cagaagcagc tggcacagat 1260 gacgcggtgc ccggagcagg agcagcggct gcagcgctta gaacggctgc ctgagctggc 1320 ccgtgtgctg cggagcgtct ttgtgtccga acgcaagcct gcgctcagca tggaggtggc 1380 ctgtgccagg atggtgggca gctgttgtac tatcatgagc cctggggaaa tggagaagca 1440 cctgctgctc ctctccgagc tgctgccgga ctggctcagc ctccaccgca tccgcaccga 1500 cacctacgtc aagctggaca aggccgcgga cctggcccac atcactgcac gcctggccca 1560 ccagacacgt gctgaggagg ggctgtgagc ctgggggcca ctgtggacag acgtgggctt 1620 cagaagctcg gtggcctggg cccaccagca ttttctttta tgaacatgat acactttggt 1680 cttcctttcc ccagcgcccc tgagggccag aggcagatgt gggctgcagg ctgcacagcc 1740 cgagggtctc tggctgcggg cggtgggccc cttcatgggg ctcacctgat ggattcacat 1800 taaaccggtt tctgtgggca cctctgtcct tgctgctggt ggggaaggga agccagatcc 1860 agcaccccct ggggggccat cgggagtgtg gctgggggtg aagggggctc tgtggcaata 1920 tggggttggg tagtgtgggt ggcaggccat cccctctaat cttggaacct ctgaatatgg 1980 gacctcccac agcaaagggt gacttttgtc attaagaaag actggggtgg gtgtggtggc 2040 tcacgcctgt aaccccagca ctttgggagg ccaaggtggg cagatcacga ggtcaagaga 2100 tcgagaccat cctggcgaac atggtgaaac cccatctcta ctaaaaataa aaaaaaaatt 2160 agccgggtgt ggtggtgggc acctgtcgtc ccagctacta gggaggctga ggcaggagaa 2220 tggtgtgaac ccaggaggca cagcttgcag tgagcgaaga tcgcaccact gcacgcactc 2280 cagcctgggc gacagagcga gactccgtct caaaaaaaaa aaatttcaag actggagagg 2340 tgatcctgaa ttgtccagct acgccccatg tcatcacagg gccttcatga cagggccaga 2400 gccagccagc tttgaagacg cggccctgcc ccgacacagg cagcctggag aagctgggca 2460 ggacaagtag gacatccctg gagcctccag aagggactgg cctctgccca caccttgact 2520 tcagtatttc tgacctccta aactctaata aagtcatgct tacagccact aaaaaaaaaa 2580 aaaaaaaaa 2589 <210> 33 <211> 1930 <212> DNA <213> Homo sapiens <400> 33 ctccgccgcc atggagcagc gccgcgtcac cgacttcttc gcgcgccgcc gccccgggcc 60 cccccgcatc gcgccgccca agctggcctg ccgcaccccc agccccgcca ggcccgcact 120 ccgcgccccg gcctccgcta ccagtggcag ccgcaagcgc gcccgcccgc ccgccgcccc 180 cggacgcgac caggccaggc caccggcccg caggagactg cggctgtcgg tggacgaggt 240 ttccagcccc agtacccccg aggccccaga catcccagcc tgcccttctc cgggccagaa 300 gataaagaaa tccaccccgg cagcaggtca gccgccccac ctgacatccg cgcaggacca 360 ggacaccatc tctgagcttg cgtcatgcct gcaacgggcc cgggagctgg gggcaagagt 420 ccgggcgctg aaggccagtg cccaggatgc tggggagtcc tgcaccccag aggccgaggg 480 ccgccctgag gagccatgtg gcgagaaggc gcccgcctac cagcgcttcc atgccctggc 540 ccagcccggc ctgccgggac tcgtgctgcc ctacaagtac caggtgctgg cggagatgtt 600 ccgcagcatg gacaccatcg tgggcatgct ccacaaccgc tccgagacgc ccacctttgc 660 caaggtccag cggggcgtcc aggacatgat gcgtaggcgt tttgaggagc gcaatgttgg 720 ccagatcaaa accgtgtacc cggcctccta ccgcttccgc caggagcgca gtgtccccac 780 cttcaaggat ggcaccagga ggtcagatta ccagctcacc atcgagccac tgctggagca 840 ggaggctgac ggagcagccc cccagctcac ggcctcgcgc ctcctgcagc gacggcagat 900 cttcagccag aagctggtgg agcatgtcaa ggagcaccac aaggccttcc tggcctccct 960 gagccccgcc atggtggtgc cggaggacca gctgacccgc tggcacccgc gcttcaacgt 1020 ggatgaagta cccgacatcg agccggccgc gctgccccag ccacccgcca cggagaagct 1080 caccactgct caggaggtgc tggcccgggc ccgcaacctg atttcaccca ggatggagaa 1140 ggccttgagt caattggccc tgcgctctgc tgcgcccagc agccccgggt ctcccaggcc 1200 agcactgccg gctaccccac cagccacccc gcctgcagcc tctcccagtg ctctgaaggg 1260 ggtgtcccag gatctgctgg agcggatccg agccaaggag gcacagaagc agctggcaca 1320 gatgacgcgg tgcccggagc aggagcagcg gctgcagcgc ttagaacggc tgcctgagct 1380 ggcccgcgtg ctgcggagcg tctttgtgtc cgaacgcaag cctgcgctca gcatggaggt 1440 ggcctgtgcc aggatggtgg gcagctgttg tactatcatg agccctgggg aaatggagaa 1500 gcacctgctg ctcctctccg agctgctgcc ggactggctc agcctccacc gcatccgcac 1560 cgacacctac gtcaagctgg acaaggccgc ggacctcgcc cacatcactg cacgcctggc 1620 ccaccagaca cgtgctgagg aggggctgtg agcctggggg ccactgtgga cagacgtggg 1680 cttcagaagc tcgctggcct gggcccacca gcattttctt ttatgaacat gatacacttt 1740 ggccttcctt tccccagcgc ccctgagggc cagaggcaga tgtgggctgc aggctgcaca 1800 gcccgagggt ctctggctgc gggcggtggg ccccttcatg gggctcacct ggtggattca 1860 cattaaaccg gtttctgtgg gcaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1920 aaaaaaaaaa 1930 <210> 34 <211> 1546 <212> DNA <213> Homo sapiens <400> 34 caggaccagg acaccatctc tgagcttgcg tcatgcctgc aacgggcccg ggagctgggg 60 gcaagagtcc gggcgctgaa ggccagtgcc caggatgctg gggagtcctg caccccagag 120 gccgagggcc gccctgagga gccatgtggc gagaaggcgc ccgcctacca gcgcttccat 180 gccctggccc agcccggcct gccgggactc gtgctgccct acaagtacca ggtgctggcg 240 gagatgttcc gcagcatgga caccatcgtg ggcatgctcc acaaccgctc cgagacgccc 300 acctttgcca aggtccagcg gggcgtccag gacatgatgc gtaggcgttt tgaggagcgc 360 aatgttggcc agatcaaaac cgtgtacccg gcctcctacc gcttccgcca ggagcgcagt 420 gtccccacct tcaaggatgg cgccaggagg tcagattacc agctcaccat cgagccactg 480 ctggagcagg aggctgacgg agcagccccc cagctcacgg cctcgcgcct cctgcagcga 540 cggcagatct tcagccagaa gctggtggag cacgtcaagg agcaccacaa ggccttcctg 600 gcctccctga gccccgccat ggtggtgccg gaggaccagc tgacccgctg gcacccgcgc 660 ttcaacgtgg atgaagtacc cgacatcgag ccggccgcgc tgccccagcc acccgccacg 720 gagaagctca ccactgctca ggaggtgctg gcccgggccc gcaacctgat ttcacccagg 780 atggagaagg ccttgagtca attggccctg cgctctgctg cgcccagcag ccccgggtct 840 cccaggccag cactgccggc taccccacca gccaccccgc ctgcagcctc tcccagtgct 900 ctgaaggggg tgtcccagga tctgctggag cggatccgag ccaaggaggc acagaagcag 960 ctggcacaga tgacgcggtg cccggagcag gagcagcggc tgcagcgctt agaacggctg 1020 cctgagctgg cccgcgtgct gcggagcgtc tttgtgtccg aacgcaagcc tgcgctcagc 1080 atggaggtgg cctgtgccag gatggtgggc agctgttgta ctatcatgag ccctgggaaa 1140 atggagaagc acctgctgct cctctccgag ctgctgccgg actggctcag cctccaccgc 1200 atccgcaccg acacctacgt caagctggac aaggccgcgg acctggccca catcactgca 1260 cgcctggccc accagacacg tgctgaggag gggctgtgag cctgggggcc actgtggaca 1320 gacgtgggct tcagaagctc gctggcctgg gcccaccagc attttctttt atgaacatga 1380 tacactttgg ccttcctttc cccagcgccc ctgagggcca gaggcagatg tgggctgcag 1440 gctgcacagc ccgagggtct ctggctgcgg gcggtgggcc ccttcatggg gctcacctgg 1500 tggattcaca ttaaaccggt ttctgtgggc aaaaaaaaaa aaaaaa 1546 <210> 35 <211> 1503 <212> DNA <213> Homo sapiens <400> 35 gcgctgaagg ccagtgccca ggatgctggg gagtcctgca ccccagaggc cgagggccgc 60 cctgaggagc catgtggcga gaaggcgccc gcctaccagc gcttccatgc cctggcccag 120 cccggcctgc cgggactcgt gctgccctac aagtaccagg tgctggcgga gatgttccgc 180 agcatggaca ccatcgtggg catgctccac aaccgctccg agacgcccac ctttgccaag 240 gtccagcggg gcgtccagga catgatgcgt aggcgttttg aggagcgcaa tgttggccag 300 atcaaaaccg tgtacccggc ctcctaccgc ttccgccagg agcgcagtgt ccccaccttc 360 aaggatggcg ccaggaggtc agattaccag ctcaccatcg agccactgct ggagcaggag 420 gctgacggag cagcccccca gctcacggcc tcgcgcctcc tgcagcgacg gcagatcttc 480 agccagaagc tggtggagca cgtcaaggag caccacaagg ccttcctggc ctccctgagc 540 cccgccatgg tggtgccgga ggaccagctg acccgctggc acccgcgctt caacgtggat 600 gaagtacccg acatcgagcc ggccgcgctg ccccagccac ccgccacgga gaagctcacc 660 actgctcagg aggtgctggc ccgggcccgc aacctgattt cacccaggat ggagaaggcc 720 ttgagtcaat tggccctgcg ctctgctgcg cccagcagcc ccgggtctcc caggccagca 780 ctgccggcta ccccaccagc caccccgcct gcagcctctc ccagtgctct gaagggggtg 840 tcccaggatc tgctggagcg gatccgagcc aaggaggcac agaagcagct ggcacagatg 900 acgcggtgcc cggagcagga gcagcggctg cagcgcttag aacggctgcc tgagctggcc 960 cgcgtgctgc ggagcgtctt tgtgtccgaa cgcaagcctg cgctcagcat ggaggtggcc 1020 tgtgccagga tggtgggcag ctgttgtact atcatgagcc ctggggaaat ggagaagcac 1080 ctgctgctcc tctccgagct gctgccggac tggctcagcc tccaccgcat ccgcaccgac 1140 acctacgtca agctggacaa ggccgcggac ctggcccaca tcactgcacg cctggcccac 1200 cagacacgtg ctgaggaggg gctgtgagcc tgggggccac tgtggacaga cgtgggcttc 1260 agaagctcgc tggcctgggc ccaccagcat tttcttttat gaacatgata cactttggcc 1320 ttcctttccc cagcgcccct gagggccaga ggcagatgtg ggctgcaggc tgcacagccc 1380 gagggtctct ggctgcgggc ggtgggcccc ttcatggggc tcacctggtg gattcacatt 1440 aaaccggttt ctgtgggcaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1500 aaa 1503 <210> 36 <211> 1492 <212> DNA <213> Homo sapiens <400> 36 agagtccggg cgctgaaggc cagtgcccag gatgctgggg agtcctgcac cccagaggcc 60 gagggccgcc ctgaggagcc atgtggcgag aaggcgcccg cctaccagcg cttccatgcc 120 ctggcccagc ccggcctgcc gggactcgtg ctgccctaca agtaccaggt gctggcggag 180 atgttccgca gcatggacac catcgtgggc atgctccaca accgctccga gacgcccacc 240 tttgccaagg tccagcgggg cgtccaggac atgatgcgta ggcgttttga ggagcgcaat 300 gttggccaga tcaaaaccgt gtacccggcc tcctaccgct tccgccagga gcgcagtgtc 360 cccaccttca aggatggcgc caggaggtca gattaccagc tcaccatcga gccactgctg 420 gagcaggagc tgacggagca gccccccagc tcacggcctc gcgcctcctg cagcgacggc 480 agatcttcag ccagaagctg gtggagcacg tcaaggagca ccacaagcct tcctggcctc 540 cctgagcccc gccatggtgg tgccggagga ccagctgacc cgctggcacc cgcgcttcaa 600 cgtggatgaa gtacccgaca tcgagccggc cgcgctgccc cagccacccg ccacggagaa 660 gctcaccact gctcaggagg tgctggcccg ggcccgcaac ctgatttcac ccaggatgga 720 gaaggccttg agtcaattgg ccctgcgctc tgctgcgccc agcagccccg ggtctcccag 780 gccagcactg ccggctaccc caccagccac cccgcctgca gcctctccca gtgctctgaa 840 gggggtgtcc caggatctgc tggagcggat ccgagccaag gaggcacaga agcagctggc 900 acagatgacg cggtgcccgg agcaggagca gcggctgcag cgcttagaac ggctgcctga 960 gctggcccgc gtgctgcgga gcgtctttgt gtccgaacgc aagcctgcgc tcagcatgga 1020 ggtggcctgt gccaggatgg tgggcagctg ttgtactatc atgagccctg gggaaatgga 1080 gaagcacctg ctgctcctct ccgagctgct gccggactgg ctcagcctcc accgcatccg 1140 caccgacacc tacgtcaagc tggacaaggc cgcggacctg gcccacatca ctgcacgcct 1200 ggcccaccag acacgtgctg aggaggggct gtgagcctgg gggccactgt ggacagacgt 1260 gggcttcaga agctcgctgg cctgggccca ccagcatttt cttttatgaa catgatacac 1320 tttggtcttc ctttccccag cgcccctgag ggccagaggc agatgtgggc tgcaggctgc 1380 acagcccgag ggtctctggc tgcgggcggt gggccccttc atggggctca cctggtggat 1440 tcacattaaa ccggtttctg tgggcaaaaa aaaaaaaaaa aaaaaaaaaa aa 1492 <210> 37 <211> 1222 <212> DNA <213> Homo sapiens <400> 37 ggcacgaggg gcgttttgag gagcgcaatg ttggccagat caaaaccgtg tacccggcct 60 cctaccgctt ccgccaggag cgcagtgtcc ccaccttcaa ggatggcgcc aggaggtcag 120 attaccagct caccatcgag ccactgctgg agcaggaggc tgacggagca gccccccagc 180 tcacggcctc gcgcctcctg cagcgacggc agatcttcag ccagaagctg gtggagcacg 240 tcaaggagca ccacaaggcc ttcctggcct ccctgagccc cgccatggtg gtgccggagg 300 accagctgac ccgctggcac ccgcgcttca acgtggatga agtacccgac atcgagccgg 360 ccgcgctgcc ccagccaccc gccacggaga agctcaccac tgctcaggag gtgctggccc 420 gggcccgcaa cctgatttca cccaggatgg agaaggcctt gagtcaattg gccctgcgct 480 ctgctgcgcc cagcagcccc gggtctccca ggccagcact gccggctacc ccaccagcca 540 ccccgcctgc agcctctccc agtgctctga agggggtgtc ccaggatctg ctggagcgga 600 tccgagccaa ggaggcacag aagcagctgg cacagatgac gcggtgcccg gagcaggagc 660 agcggctgca gcgcttagaa cggctgcctg agctggcccg cgtgctgcgg agcgtctttg 720 tgtccgaacg caagcctgcg ctcagcatgg aggtggcctg tgccaggatg gtgggcagct 780 gttgtactat catgagccct ggggaaatgg agaagcacct gctgctcctc tccgagctgc 840 tgccggactg gctcagcctc caccgcatcc gcaccgacac ctacgtcaag ctggacaagg 900 ccgcggacct ggcccacatc actgcacgcc tggcccacca gacacgtgct gaggaggggc 960 tgtgagcctg ggggccactg tggacagacg tgggcttcag aagctcgctg gcctgggccc 1020 accagcattt tcttttatga acatgataca ctttggtctt cctttcccca gcgcccctga 1080 gggccagagg cagatgtggg ctgcaggctg cacagcccga gggtctctgg ctgcgggcgg 1140 tgggcccctt catggggctc acctggtgga ttcacattaa accggtttct gtgggcaaaa 1200 aaaaaaaaaa aaaaaaaaaa aa 1222 <210> 38 <211> 1215 <212> DNA <213> Homo sapiens <400> 38 cgtcagttgg tcacgtggtt gttcggagcg ggcgagcgga gttagcaggg ctttactgca 60 gagcgcgccg ggcactccag cgaccgtggg gatcagcgta ggtgagctgt ggccttttgc 120 gaggtgctgc agccatagct acgtgcgttc gctacgagga ttgagcgtct ccacccagta 180 agtgggcaag aggcggcagg aagtgggtac gcaggggcgc aaggcgcaca gcctctagac 240 gactcgcttt ccctccggcc aacctctgaa gccgcgtcct actttgacag ctgcagggcc 300 gcggcctggt cttctgtgct tcaccatcta cataatgaat cccagtatga agcagaaaca 360 agaagaaatc aaagagaata taaagaatag ttctgtccca agaagaactc tgaagatgat 420 tcagccttct gcatctggat ctcttgttgg aagagaaaat gagctgtccg caggcttgtc 480 caaaaggaaa catcggaatg accacttaac atctacaact tccagccctg gggttattgt 540 cccagaatct agtgaaaata aaaatcttgg aggagtcacc caggagtcat ttgatcttat 600 gattaaagaa aatccatcct ctcagtattg gaaggaagtg gcagaaaaac ggagaaaggc 660 gctgtatgaa gcacttaagg aaaatgagaa acttcataaa gaaattgaac aaaaggacaa 720 tgaaattgcc cgcctgaaaa aggagaataa agaactggca gaagtagcag aacatgtaca 780 gtatatggca gagctaatag agagactgaa tggtgaacct ctggataatt ttgaatcact 840 ggataatcag gaatttgatt ctgaagaaga aactgttgag gattctctag tggaagactc 900 agaaattggc acgtgtgctg aaggaactgt atcttcctct acggatgcaa agccatgtat 960 atgaaatgca ttaatatttg actgttgaga attttactgc cgaagtttac ctccactagt 1020 tctttgtagc agagtacata actacataat gccaactctg gaatcaaatt tccttgtttg 1080 aatcctggga ccctattgca ttaaagtaca aatactatgt atttttaatc tatgatggtt 1140 tatgtgaata ggattttctc agttgtcagc catgacttat gtttattact aaataaactt 1200 caaactcctg ttgaa 1215 <210> 39 <211> 1224 <212> DNA <213> Homo sapiens <400> 39 gttcggagcg ggcgagcgga gttagcaggg ctttactgca gagcgcgccg ggcactccag 60 cgaccgtggg gatcagcgta ggtgagctgt ggccttttgc gaggtgctgc agccatagct 120 acgtgcgttc gctacgagga ttgagcgtct ccacccagta agtgggcaag aggcggcagg 180 aagtgggtac gcaggggcgc aaggcgcaca gcctctagac gactcgcttt ccctccggcc 240 aacctctgaa gccgcgtcct actttgacag ctgcagggcc gcggcctggt cttctgtgct 300 tcaccatcta cataatgaat cccagtatga agcagaaaca agaagaaatc aaagagaata 360 taaagaatag ttctgtccca agaagaactc tgaagatgat tcagccttct gcatctggat 420 ctcttgttgg aagagaaaat gagctgtccg caggcttgtc caaaaggaaa catcggaatg 480 accacttaac atctacaact tccagccctg gggttattgt cccagaatct agtgaaaata 540 aaaatcttgg aggagtcacc caggagtcat ttgatcttat gattaaagaa aatccatcct 600 ctcagtattg gaaggaagtg gcagaaaaac ggagaaaggc gctgtatgaa gcacttaagg 660 aaaatgagaa acttcataaa gaaattgaac aaaaggacaa tgaaattgcc cgcctgaaaa 720 aggagaataa agaactggca gaagtagcag aacatgtaca gtatatggca gagctaatag 780 agagactgaa tggtgaacct ctggataatt ttgaatcact ggataatcag gaatttgatt 840 ctgaagaaga aactgttgag gattctctag tggaagactc agaaattggc acgtgtgctg 900 aaggaactgt atcttcctct acggatgcaa agccatgtat atgaaatgca ttaatatttg 960 actgttgaga attttactgc cgaagtttac ctccactagt tctttgtagc agagtacata 1020 actacataat gccaactctg gaatcaaatt tccttgtttg aatcctggga ccctattgca 1080 ttaaagtaca aatactatgt atttttaatc tatgatggtt tatgtgaata ggattttctc 1140 agttgtcagc catgacttat gtttattact aaataaactt caaactcctg tggaaaaaaa 1200 aaaaaaaaaa aaaaaaaaaa aaaa 1224 <210> 40 <211> 1223 <212> DNA <213> Homo sapiens <400> 40 cactccagcg accgtgggga tcagcgtagg tgagctgtgg ccttttgcga ggtgctgcag 60 ccatagctac gtgcgttcgc tacgaggatt gagcgtctcc acccagtaag tgggcaagag 120 gcggcaggaa gtgggtacgc aggggcgcaa ggcgcacagc ctctagacga ctcgctttcc 180 ctccggccaa cctctgaagc cgcgtcctac tttgacagct gcagggccgc ggcctggtct 240 tctgtgcttc accatctaca taatgaatcc cagtatgaag cagaaacaag aagaaatcaa 300 agagaatata aagaatagtt ctgtcccaag aagaactctg aagatgattc agccttctgc 360 atctggatct cttgttggaa gagaaaatga gctgtccgca ggcttgtcca aaaggaaaca 420 tcggaatgac cacttaacat ctacaacttc cagccctggg gttattgtcc cagaatctag 480 tgaaaataaa aatcttggag gagtcaccca ggagtcattt gatcttatga ttaaagaaaa 540 tccatcctct cagtattgga aggaagtggc agaaaaacgg agaaaggcgc tgtatgaagc 600 acttaaggaa aatgagaaac ttcataaaga aattgaacaa aaggacaatg aaattgcccg 660 cctgaaaaag gagaataaag aactggcaga agtagcagaa catgtacagt atatggcaga 720 gctaatagag agactgaatg gtgaacctct ggataatttt gaatcactgg ataatcagga 780 atttgattct gaagaagaaa ctgttgagga ttctctagtg gaagactcag aaattggcac 840 gtgtgctgaa ggaactgtat cttcctctac ggatgcaaag ccatgtatat gaaatgcatt 900 aatatttgac tgttgagaat tttactgccg aagtttacct ccactagttc tttgtagcag 960 agtacataac tacataatgc caactctgga atcaaatttc cttgtttgaa tcctgggacc 1020 ctattgcatt aaagtacaaa tactatgtat ttttaatcta tgatggttta tgtgaatagg 1080 attttctcag ttgtcagcca tgacttatgt ttattactaa ataaacttca aactcctgtt 1140 gaacattgtg tataacttag aataatgaaa tataaggagt atgtgtataa aaaaaaaaaa 1200 aaaaaaaaaa aacaaaaaaa aaa 1223 <210> 41 <211> 961 <212> DNA <213> Homo sapiens <400> 41 tcttctgtgc ttcaccatct acataatgaa tcccagtatg aagcagaaac aagaagaaat 60 caaagagaat ataaagaata gttctgtccc aagaagaact ctgaagatga ttcagccttc 120 tgcatctggw tctcttgttg gaagagaaaa tgagctgtcc gcaggcttgt ccaaaaggaa 180 acatcggaat gaccacttaa catctacaac ttccagccct ggggttattg tcccagaatc 240 tagtgaaaat aaaaatcttg gaggagtcac ccaggagtca tttgatctta tgattaaaga 300 aaatccatcc tctcagtatt ggaaggaagt ggcagaaaaa cggagaaagg cgctgtatga 360 agcacttaag gaaaatgaga aacttcataa agaaattgaa caaaaggaca atgaaattgc 420 ccgcctgaaa aaggagaata aagaactggc agaagtagca gaacatgtac agtatatggc 480 agagctaata gagagactga atggtgaacc tctggataat tttgaatcac tggataatca 540 ggaatttgat tctgaagaag aaactgttga ggattctcta gtggaagact cagaaattgg 600 cacgtgtgct gaaggaactg tatcttcctc tacggatgca aagccatgta tatgaaatgc 660 attaatattt gactgttgag aattttactg ccgaagttta cctccactag ttctttgtag 720 cagagtacat aactacataa tgccaactct ggaatcaaat ttccttgttt gaatcctggg 780 accctattgc attaaagtac aaatactatg tatttttaat ctatgatggt ttatgtgaat 840 aggattttct cagttgtcag ccatgactta tgtttattac taaataaact tcaaactcct 900 gttgaacatt gtgtataact tagaataatg aaatataagg agtatgtgta gaaaaaaaaa 960 a 961 <210> 42 <211> 1133 <212> DNA <213> Homo sapiens <400> 42 gtctgcgtca gttggtcacg tggttgttcg gagcgggcga gcggagttag cagggcttta 60 ctgcagagcg cgccgggcac tccagcgacc gtggggatca gcgtaggtga gctgtggcct 120 tttgcgaggt gctgcagcca tagctacgtg cgttcgctac gaggattgag cgtctccacc 180 catcttctgt gcttcaccat ctacataatg aatcccagta tgaagcagaa acaagaagaa 240 atcaaagaga atataaagac tagttctgtc ccaagaagaa ctctgaagat gattcagcct 300 tctgcatctg gatctcttgt tggaagagaa aatgagctgt ccgcaggctt gtccaaaagg 360 aaacatcgga atgaccactt aacatctaca acttccagcc ctggggttat tgtcccagaa 420 tctagtgaaa ataaaaatct tggaggagtc acccaggagt catttgatct tatgattaaa 480 gaaaatccat cctctcagta ttggaaggaa gtggcagaaa aacggagaaa ggcgctgtat 540 gaagcactta aggaaaatga gaaacttcat aaagaaattg aacaaaagga caatgaaatt 600 gcccgcctga aaaaggagaa taaagaactg gcagaagtag cagaacatgt acagtatatg 660 gcagagctaa tagagagact gaatggtgaa cctctggata attttgaatc actggataat 720 caggaatttg attctgaaga agaaactgtt gaggattctc tagtggaaga ctcagaaatt 780 ggcacgtgtg ctgaaggaac tgtatcttcc tctacggatg caaagccatg tatatgaaat 840 gcattaatat ttgactgttg agaattttac tgccgaagtt tacctccact agttctttgt 900 agcagagtac ataactacat aatgccaact ctggaatcaa atttccttgt ttgaatcctg 960 ggaccctatt gcattaaagt acaaatacta tgtattttta atctatgatg gtttatgtga 1020 ataggatttt ctcagttgtc agccatgact tatgtttatt actaaataaa cttcaaactc 1080 ctgttgaaca ttgtgtataa cttagaataa tgaaatataa ggagtatgtg tag 1133 <210> 43 <211> 3067 <212> DNA <213> Homo sapiens <400> 43 catcctggga acctccacgc gactttggtg gaggtagttc tttggcagcg ggcatggcgg 60 gtaccgtggt gctggacgat gtggagctgc gggaggctca gagagattac ctggacttcc 120 tggacgacga ggaagaccag ggaatttatc agagcaaagt tcgggagctg atcagtgaca 180 accaataccg gctgattgtc aatgtgaatg acctgcgcag gaaaaacgag aagagggcta 240 accggcttct gaacaatgcc tttgaggagc tggttgcctt ccagcgggcc ttaaaggatt 300 ttgtggcctc cattgatgct acctatgcca agcagtatga ggagttctac gtaggactgg 360 aaggcagctt tggctccaag cacgtctccc cgcggactct tacctcctgc ttcctcagct 420 gtgtggtctg tgtggagggc attgtcacta aatgttctct agttcgtccc aaagtcgtcc 480 gcagtgtcca ctactgtcct gctactaaga agaccataga gcgacgttat tctgatctca 540 ccaccctggt ggcctttccc tccagctctg tctatcctac caaggatgag gagaacaatc 600 cccttgagac agaatatggc ctttctgtct acaaggatca ccagaccatc accatccagg 660 agatgccgga gaaggcccca gccggccagc tcccccgctc tgtggacgtc attctggatg 720 atgacttggt ggataaagcg aagcctggtg accgggttca ggtggtggga acctaccgtt 780 gccttcctgg aaagaaggga ggctacacct ctgggacctt caggactgtc ctgattgcct 840 gtaatgttaa gcagatgagc aaggatgctc agccctcttt ctctgctgag gatatagcca 900 agatcaagaa gttcagtaaa acccgatcca aggatatctt tgaccagctg gccaagtcat 960 tggccccaag tatccatggg catgactatg tcaagaaagc aatcctctgc ttgctcttgg 1020 gaggggtgga acgagaccta gaaaatggca gccacatccg tggggacatc aatattcttc 1080 taataggaga cccatccgtt gccaagtctc agcttctgcg gtatgtgctt tgcactgcac 1140 cccgagctat ccccaccact ggccggggct cctctggagt gggtctgacg gctgctgtca 1200 ccacagacca ggaaacagga gagcgccgtc tggaagcagg ggccatggtc ctggctgacc 1260 gaggcgtggt ttgcattgat gaatttgaca aaatgtctga catggatcgc acagccatcc 1320 atgaagtgat ggagcagggt cgagtgacca ttgccaaggc tggcatccat gctcggctga 1380 atgcccgctg cagtgttttg gcagctgcca accctgtcta cggcaggtat gaccagtata 1440 agactccaat ggagaacatt gggctacagg actcactgct gtcacgattt gacttgctct 1500 tcatcatgct ggatcagatg gatcctgagc aggatcggga gatctcagac catgtccttc 1560 ggatgcaccg ttacagagca cctggggagc aggatggcga tgctatgccc ttgggtagtg 1620 ctgtggatat cctggccaca gatgatccca actttagcca ggaagatcag caggacaccc 1680 agatttatga gaagcatgac aaccttctac atgggaccaa gaagaaaaag gagaagatgg 1740 tgagtgcagc attcatgaag aagtacatcc atgtggccaa aatcatcaag cctgtcctga 1800 cacaggagtc ggccacctac attgcagaag agtattcacg cctgcgcagc caggatagca 1860 tgagctcaga caccgccagg acatctccag ttacagcccg aacactggaa actctgattc 1920 gactggccac agcccatgcg aaggcccgca tgagcaagac tgtggacctg caggatgcag 1980 aggaagctgt ggagttggtc cagtatgctt actttaagaa ggttctggag aaggagaaga 2040 aacgtaagaa gcgaagtgag gatgaatcag agacagaaga tgaagaggag aaaagccaag 2100 aggaccagga gcagaagagg aagagaagga agactcgcca gccagatgcc aaagatgggg 2160 attcatacga cccctatgac ttcagtgaca cagaggagga aatgcctcaa gtacacactc 2220 caaagacggc agactcacag gagaccaagg aatcccagaa agtggagttg agtgaatcca 2280 ggttgaaggc attcaaggtg gccctcttgg atgtgttccg ggaagctcat gcgcagtcaa 2340 tcggcatgaa tcgcctcaca gaatccatca accgggacag cgaagagccc ttctcttcag 2400 ttgagatcca ggctgctctg agcaagatgc aggatgacaa tcaggtcatg gtgtctgagg 2460 gcatcatctt cctcatctga ggaggcctcg tctctgaact tgggttgtgc cgagagagtt 2520 tgttctgtgt ttcccaccct ctccctgacc caagtctttg cctctactcc cttaacagtg 2580 ttgaattcaa ctgaaggcga ggaatgttgg tgatgaagct gagttcagga ctcggtggac 2640 cctttgggaa tgggtcatga aagctgccat ggggtgagga aagaggagac agtgggagag 2700 gacaatgact attgcatctt cattgcaaaa gcactggctc atccgcccta cttcccatcc 2760 cacacaaacc caattgtaaa taacatatga cttctgagta cttttggggg cacaactgtt 2820 ttctgtttgc tgtttttttg ttttgttttt tttctccaga gcactttggt ctagactagg 2880 ctttgggtgg ttccaattgg tggagagaag ctctgaggca cgtcatgcag gtcaagaaag 2940 ctttctttgc agtagcacca gttaaggtga atatgtattg tatcacaaaa caaacccaat 3000 atccagatga atatccgaga tgttgaataa acttagccat ttcgtaaaaa aaaaaaaaaa 3060 aaaaaaa 3067 <210> 44 <211> 3143 <212> DNA <213> Homo sapiens <400> 44 ctcgaggtaa cctttggtgg cgggaagagt tcggaagttt tcgcgccggg gtggagtcat 60 cctgggaacc tccacgcgac tttggtggag gtagttcttt ggcagcgggc atggcgggta 120 ccgtggtgct ggacgatgtg gagctgcggg aggctcagag agattacctg gacttcctgg 180 acgacgagga agaccaggga atttatcaga gcaaagttcg ggagctgatc agtgacaacc 240 aataccggct gattgtcaat gtgaatgacc tgcgcaggaa aaacgagaag agggctaacc 300 ggcttctgaa caatgccttt gaggagctgg ttgccttcca gcgggcctta aaggattttg 360 tggcctccat tgatgctacc tatgccaagc agtatgagga gttctacgta ggactggaag 420 gcagctttgg ctccaagcac gtctccccgc ggactcttac ctcctgcttc ctcagctgtg 480 tggtctgtgt ggagggcatt gtcactaaat gttctctagt tcgtcccaaa gtcgtccgca 540 gtgtccacta ctgtcctgct actaagaaga ccatagagcg acgttattct gatctcacca 600 ccctggtggc ctttccctcc agctctgtct atcctaccaa ggatgaggag aacaatcccc 660 ttgagacaga atatggcctt tctgtctaca aggatcacca gaccatcacc atccaggaga 720 tgccggagaa ggccccagcc ggccagctcc cccgctctgt ggacgtcatt ctggatgatg 780 acttggtgga taaagcgaag cctggtgacc gggttcaggt ggtgggaacc taccgttgcc 840 ttcctggaaa gaagggaggc tacacctctg ggaccttcag gactgtcctg attgcctgta 900 atgttaagca gatgagcaag gatgctcagc cctctttctc tgctgaggat atagccaaga 960 tcaagaagtt cagtaaaacc cgatccaagg atatctttga ccagctggcc aagtcattgg 1020 ccccaagtat ccatgggcat gactatgtca agaaagcaat cctctgcttg ctcttgggag 1080 gggtggaacg agacctagaa aatggcagcc acatccgtgg ggacatcaat attcttctaa 1140 taggagaccc atccgttgcc aagtctcagc ttctgcggta tgtgctttgc actgcacccc 1200 gagctatccc caccactggc cggggctcct ctggagtggg tctgacggct gctgtcacca 1260 cagaccagga aacaggagag cgccgtctgg aagcaggggc catggtcctg gctgaccgag 1320 gcgtggtttg cattgatgaa tttgacaaaa tgtctgacat ggatcgcaca gccatccatg 1380 aagtgatgga gcagggtcga gtgaccattg ccaaggctgg catccatgct cggctgaatg 1440 cccgctgcag tgttttggca gctgccaacc ctgtctacgg caggtatgac cagtataaga 1500 ctccaatgga gaacattggg ctacaggact cactgctgtc acgatttgac ttgctcttca 1560 tcatgctgga tcagatggat cctgagcagg atcgggagat ctcagaccat gtccttcgga 1620 tgcaccgtta cagagcacct ggggagcagg atggcgatgc tatgcccttg ggtagtgctg 1680 tggatatcct ggccacagat gatcccaact ttagccagga agatcagcag gacacccaga 1740 tttatgagaa gcatgacaac cttctacatg ggaccaagaa gaaaaaggag aagatggtga 1800 gtgcagcatt catgaagaag tacatccatg tggccaaaat catcaagcct gtcctgacac 1860 aggagtcggc cacctacatt gcagaagagt attcacgcct gcgcagccag gatagcatga 1920 gctcagacac cgccaggaca tctccagtta cagcccgaac actggaaact ctgattcgac 1980 tggccacagc ccatgcgaag gcccgcatga gcaagactgt ggacctgcag gatgcagagg 2040 aagctgtgga gttggtccag tatgcttact ttaagaaggt tctggagaag gagaagaaac 2100 gtaagaagcg aagtgaggat gaatcagaga cagaagatga agaggagaaa agccaagagg 2160 accaggagca gaagaggaag agaaggaaga ctcgccagcc agatgccaaa gatggggatt 2220 catacgaccc ctatgacttc agtgacacag aggaggaaat gcctcaagta cacactccaa 2280 agacggcaga ctcacaggag accaaggaat cccagaaagt ggagttgagt gaatccaggt 2340 tgaaggcatt caaggtggcc ctcttggatg tgttccggga agctcatgcg cagtcaatcg 2400 gcatgaatcg cctcacagaa tccatcaacc gggacagcga agagcccttc tcttcagttg 2460 agatccaggc tgctctgagc aagatgcagg atgacaatca ggtcatggtg tctgagggca 2520 tcatcttcct catctgagga ggcctcgtct ctgaacttgg gttgtgccga gagagtttgt 2580 tctgtgtttc ccaccctctc cctgacccaa gtctttgcct ctactccctt aacagtgttg 2640 aattcaactg aaggcgagga atgttggtga tgaagctgag ttcaggactc ggtggaccct 2700 ttgggaatgg gtcatgaaag ctgccatggg gtgaggaaag aggagacagt gggagaggac 2760 aatgactatt gcatcttcat tgcaaaagca ctggctcatc cgccctactt cccatcccac 2820 acaaacccaa ttgtaaataa catatgactt ctgagtactt ttgggggcac aactgttttc 2880 tgtttgctgt ttttttgttt tgtttttttt ctccagagca ctttggtcta gactaggctt 2940 tgggtggttc caattggtgg agagaagctc tgaggcacgt catgcaggtc aagaaagctt 3000 tctttgcagt agcaccagtt aaggtgaata tgtattgtat cacaaaacaa acccaatatc 3060 cagatgaata tccgagatgt tgaataaact tagccatttc gtacacatgg taaaaaaaaa 3120 aaaaaaaaaa aaaaaaaaaa aaa 3143 <210> 45 <211> 3084 <212> DNA <213> Homo sapiens <400> 45 atcctgggaa cctccacgcg actttggtgg aggtagttct ttggcagcgg gcatggcggg 60 taccgtggtg ctggacgatg tggagctgcg ggaggctcag agagattacc tggacttcct 120 ggacgacgag gaagaccagg gaatttatca gagcaaagtt cgggagctga tcagtgacaa 180 ccaataccgg ctgattgtca atgtgaatga cctgcgcagg aaaaacgaga agagggctaa 240 ccggcttctg aacaatgcct ttgaggagct ggttgccttc cagcgggcct taaaggattt 300 tgtggcctcc attgatgcta cctatgccaa gcagtatgag gagttctacg taggactgga 360 aggcagcttt ggctccaagc acgtctcccc gcggactctt acctcctgct tcctcagctg 420 tgtggtctgt gtggagggca ttgtcactaa atgttctcta gttcgtccca aagtcgtccg 480 cagtgtccac tactgtcctg ctactaagaa gaccatagag cgacgttatt ctgatctcac 540 caccctggtg gcctttccct ccagctctgt ctatcctacc aaggatgagg agaacaatcc 600 ccttgagaca gaatatggcc tttctgtcta caaggatcac cagaccatca ccatccagga 660 gatgccggag aaggccccag ccggccagct cccccgctct gtggacgtca ttctggatga 720 tgacttggtg gataaagcga agcctggtga ccgggttcag gtggtgggaa cctaccgttg 780 ccttcctgga aagaagggag gctacacctc tgggaccttc aggactgtcc tgattgcctg 840 taatgttaag cagatgagca aggatgctca gccctctttc tctgctgagg atatagccaa 900 gatcaagaag ttcagtaaaa cccgatccaa ggatatcttt gaccagctgg ccaagtcatt 960 ggccccaagt atccatgggc atgactatgt caagaaagca atcctctgct tgctcttggg 1020 aggggtggaa cgagacctag aaaatggcag ccacatccgt ggggacatca atattcttct 1080 aataggagac ccatccgttg ccaagtctca gcttctgcgg tatgtgcttt gcactgcacc 1140 ccgagctatc cccaccactg gccggggctc ctctggagtg ggtctgacgg ctgctgtcac 1200 cacagaccag gaaacaggag agcgccgtct ggaagcaggg gccatggtcc tggctgaccg 1260 aggcgtggtt tgcattgatg aatttgacaa aatgtctgac atggatcgca cagccatcca 1320 tgaagtgatg gagcagggtc gagtgaccat tgccaaggct ggcatccatg ctcggctgaa 1380 tgcccgctgc agtgttttgg cagctgccaa ccctgtctac ggcaggtatg accagtataa 1440 gactccaatg gagaacattg ggctacagga ctcactgctg tcacgatttg acttgctctt 1500 catcatgctg gatcagatgg atcctgagca ggatcgggag atctcagacc atgtccttcg 1560 gatgcaccgt tacagagcac ctggggagca ggatggcgat gctatgccct tgggtagtgc 1620 tgtggatatc ctggccacag atgatcccaa ctttagccag gaagatcagc aggacaccca 1680 gatttatgag aagcatgaca accttctaca tgggaccaag aagaaaaagg agaagatggt 1740 gagtgcagca ttcatgaaga agtacatcca tgtggccaaa atcatcaagc ctgtcctgac 1800 acaggagtcg gccacctaca ttgcagaaga gtattcacgc ctgcgcagcc aggatagcat 1860 gagctcagac accgccagga catctccagt tacagcccga acactggaaa ctctgattcg 1920 actggccaca gcccatgcga aggcccgcat gagcaagact gtggacctgc aggatgcaga 1980 ggaagctgtg gagttggtcc agtatgctta ctttaagaag gttctggaga aggagaagaa 2040 acgtaagaag cgaagtgagg atgaatcaga gacagaagat gaagaggaga aaagccaaga 2100 ggaccaggag cagaagagga agagaaggaa gactcgccag ccagatgcca aagatgggga 2160 ttcatacgac ccctatgact tcagtgacac agaggaggaa atgcctcaag tacacactcc 2220 aaagacggca gactcacagg agaccaagga atcccagaaa gtggagttga gtgaatccag 2280 gttgaaggca ttcaaggtgg ccctcttgga tgtgttccgg gaagctcatg cgcagtcaat 2340 cggcatgaat cgcctcacag aatccatcaa ccgggacagc gaagagccct tctcttcagt 2400 tgagatccag gctgctctga gcaagatgca ggatgacaat caggtcatgg tgtctgaggg 2460 catcatcttc ctcatctgag gaggcctcgt ctctgaactt gggttgtgcc gagagagttt 2520 gttctgtgtt tcccaccctc tccctgaccc aagtctttgc ctctactccc ttaacagtgt 2580 tgaattcaac tgaaggcgag gaatgttggt gatgaagctg agttcaggac tcggtggacc 2640 ctttgggaat gggtcatgaa agctgccatg gggtgaggaa agaggagaca gtgggagagg 2700 acaatgacta ttgcatcttc attgcaaaag cactggctca tccgccctac ttcccatccc 2760 acacaaaccc aattgtaaat aacatatgac ttctgagtac ttttgggggc acaactgttt 2820 tctgtttgct gtttttttgt tttgtttttt ttctccagag cactttggtc tagactaggc 2880 tttgggtggt tccaattggt ggagagaagc tctgaggcac gtcatgcagg tcaagaaagc 2940 tttctttgca gtagcaccag ttaaggtgaa tatgtattgt atcacaaaac aaacccaata 3000 tccagatgaa tatccgagat gttgaataaa cttagccatt tcgtacacat ggaaaaaaaa 3060 aaaaaaaaaa aaaaaaaaaa aaaa 3084 <210> 46 <211> 3091 <212> DNA <213> Homo sapiens <400> 46 attaccaatc gcgaaaccgc gactttggtg gaggtagttc tttggcagcg ggcatggcgg 60 gtaccgtggt gctggacgat gtggagctgc gggaggctca gagagattac ctggacttcc 120 tggacgacga ggaagaccag ggaatttatc agagcaaagt tcgggagctg atcagtgaca 180 accaataccg gctgattgtc aatgtgaatg acctgcgcag gaaaaacgag aagagggcta 240 accggcttct gaacaatgcc tttgaggagc tggttgcctt ccagcgggcc ttaaaggatt 300 ttgtggcctc cattgatgct acctatgcca agcagtatga ggagttctac gtaggactgg 360 aaggcagctt tggctccaag cacgtctccc cgcggactct tacctcctgc ttcctcagct 420 gtgtggtctg tgtggagggc attgtcacta aatgttctct agttcgtccc aaagtcgtcc 480 gcagtgtcca ctactgtcct gctactaaga agaccataga gcgacgttat tctgatctca 540 ccaccctggt ggcctttccc tccagctctg tctatcctac caaggatgag gagaacaatc 600 cccttgagac agaatatggc ctttctgtct acaaggatca ccagaccatc accatccagg 660 agatgccgga gaaggcccca gccggccagc tcccccgctc tgtggacgtc attctggatg 720 atgacttggt ggataaagcg aagcctggtg accgggttca ggtggtggga acctaccgtt 780 gccttcctgg aaagaaggga ggctacacct ctgggacctt caggactgtc ctgattgcct 840 gtaatgttaa gcagatgagc aaggatgctc agccctcttt ctctgctgag gatatagcca 900 agatcaagaa gttcagtaaa acccgatcca aggatatctt tgaccagctg gccaagtcat 960 tggccccaag tatccatggg catgactatg tcaagaaagc aatcctctgc ttgctcttgg 1020 gaggggtgga acgagaccta gaaaatggca gccacatccg tggggacatc aatattcttc 1080 taataggaga cccatccgtt gccaagtctc agcttctgcg gtatgtgctt tgcactgcac 1140 cccgagctat ccccaccact ggccggggct cctctggagt gggtctgacg gctgctgtca 1200 ccacagacca ggaaacagga gagcgccgtc tggaagcagg ggccatggtc ctggctgacc 1260 gaggcgtggt ttgcattgat gaatttgaca aaatgtctga catggatcgc acagccatcc 1320 atgaagtgat ggagcagggt cgagtgacca ttgccaaggc tggcatccat gctcggctga 1380 atgcccgctg cagtgttttg gcagctgcca accctgtcta cggcaggtat gaccagtata 1440 agactccaat ggagaacatt gggctacagg actcactgct gtcacgattt gacttgctct 1500 tcatcatgct ggatcagatg gatcctgagc aggatcggga gatctcagac catgtccttc 1560 ggatgcaccg ttacagagca cctggggagc aggatggcga tgctatgccc ttgggtagtg 1620 ctgtggatat cctggccaca gatgatccca actttagcca ggaagatcag caggacaccc 1680 agatttatga gaagcatgac aaccttctac atgggaccaa gaagaaaaag gagaagatgg 1740 tgagtgcagc attcatgaag aagtacatcc atgtggccaa aatcatcaag cctgtcctga 1800 cacaggagtc ggccacctac attgcagaag agtattcacg cctgcgcagc caggatagca 1860 tgagctcaga caccgccagg acatctccag ttacagcccg aacactggaa actctgattc 1920 gactggccac agcccatgcg aaggcccgca tgagcaagac tgtggacctg caggatgcag 1980 aggaagctgt ggagttggtc cagtatgctt actttaagaa ggttctggag aaggagaaga 2040 aacgtaagaa gcgaagtgag gatgaatcag agacagaaga ttgaagagga gaaaagccaa 2100 gaggaccagg agcagaagag gaagagaagg aagactcgcc agccagatgc caaagatggg 2160 gattcatacg acccctatga cttcagtgac acagaggagg aaatgcctca agtacacact 2220 ccaaagacgg cagactcaca ggagaccaag gaatcccaga aagtggagtt gagtgaatcc 2280 aggttgaagg cattcaaggt ggccctcttg gatgtgttcc gggaagctca tgcgcagtca 2340 atcggcatga atcgcctcac agaatccatc aaccgggaca gcaaagagcc cttctcttca 2400 gttgagatcc aggctgctct gagcaagatg caggatgaca atcaggtcat ggtgtctgag 2460 ggcatcatct tcctcatctg aggaggcctc gtctctgaac ttgggttgtg ccgagagagt 2520 ttgttctgtg tttcccaccc tctccctgac ccaagtcttt gcctctactc ccttaacagt 2580 gttgaattca actgaaggcg aggaatgttg gtgatgaagc tgagttcagg actcggtgga 2640 ccctttggga atgggtcatg aaagctgcca tggggtgagg aaagaggaga cagtgggaga 2700 ggacaatgac tattgcatct tcattgcaaa agcactggct catccgccct acttcccatc 2760 ccacacaaac ccaattgtaa ataacatatg acttctgagt acttttgggg gcacaactgt 2820 tttctgtttg ctgttttttt gttttgtttt ttttctccag agcactttgg tctagactag 2880 gctttgggtg gttccaattg gtggagagaa gctctgaggc acgtcatgca ggtcaagaaa 2940 gctttctttg cagtagcacc agttaaggtg aatatgtatt gtatcacaaa acaaacccaa 3000 tatccagatg aatatccgag atgttgaata aacttagcca tttcgtacac atggaaaaga 3060 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a 3091 <210> 47 <211> 3061 <212> DNA <213> Homo sapiens <400> 47 cggcacgagg cgactttggt ggaggtagtt ctttggcagc gggcatggcg ggtaccgtgg 60 tgctggacga tgtggagctg cgggaggctc agagagatta cctggacttc ctggacgacg 120 aggaagacca gggaatttat cagagcaaag ttcgggagct gatcagtgac aaccaatacc 180 ggctgattgt caatgtgaat gacctgcgca ggaaaaacga gaagagggct aaccggcttc 240 tgaacaatgc ctttgaggag ctggttgcct tccagcgggc cttaaaggat tttgtggcct 300 ccattgatgc tacctatgcc aagcagtatg aggagttcta cgtaggactg gaaggcagct 360 ttggctccaa gcacgtctcc ccgcggactc ttacctcctg cttcctcagc tgtgtggtct 420 gtgtggaggg cattgtcact aaatgttctc tagttcgtcc caaagtcgtc cgcagtgtcc 480 actactgtcc tgctactaag aagaccatag agcgacgtta ttctgatctc accaccctgg 540 tggcctttcc ctccagctct gtctatccta ccaaggatga ggagaacaat ccccttgaga 600 cagaatatgg cctttctgtc tacaaggatc accagaccat caccatccag gagatgccgg 660 agaaggcccc agccggccag ctcccccgct ctgtggacgt cattctggat gatgacttgg 720 tggataaagc gaagcctggt gaccgggttc aggtggtggg aacctaccgt tgccttcctg 780 gaaagaaggg aggctacacc tctgggacct tcaggactgt cctgattgcc tgtaatgtta 840 agcagatgag caaggatgct cagccctctt tctctgctga ggatatagcc aagatcaaga 900 agttcagtaa aacccgatcc aaggatatct ttgaccagct ggccaagtca ttggccccaa 960 gtatccatgg gcatgactat gtcaagaaag caatcctctg cttgctcttg ggaggggtgg 1020 aacgagacct agaaaatggc agccacatcc gtggggacat caatattctt ctaataggag 1080 acccatccgt tgccaagtct cagcttctgc ggtatgtgct ttgcactgca ccccgagcta 1140 tccccaccac tggccggggc tcctctggag tgggtctgac ggctgctgtc accacagacc 1200 aggaaacagg agagcgccgt ctggaagcag gggccatggt cctggctgac cgaggcgtgg 1260 tttgcattga tgaatttgac aaaatgtctg acatggatcg cacagccatc catgaagtga 1320 tggagcaggg tcgagtgacc attgccaagg ctggcatcca tgctcggctg aatgcccgct 1380 gcagtgtttt ggcagctgcc aaccctgtct acggcaggta tgaccagtat aagactccaa 1440 tggagaacat tgggctacag gactcactgc tgtcacgatt tgacttgctc ttcatcatgc 1500 tggatcagat ggatcctgag caggatcggg agatctcaga ccatgtcctt cggatgcacc 1560 gttacagagc acctggggag caggatggcg atgctatgcc cttgggtagt gctgtggata 1620 tcctggccac agatgatccc aactttagcc aggaagatca gcaggacacc cagatttatg 1680 agaagcatga caaccttcta catgggacca agaagaaaaa ggagaagatg gtgagtgcag 1740 cattcatgaa gaagtacatc catgtggcca aaatcatcaa gcctgtcctg acacaggagt 1800 cggccaccta cattgcagaa gagtattcac gcctgcgcag ccaggatagc atgagctcag 1860 acaccgccag gacatctcca gttacagccc gaacactgga aactctgatt cgactggcca 1920 cagcccatgc gaaggcccgc atgagcaaga ctgtggacct gcaggatgca gaggaagctg 1980 tggagttggt ccagtatgct tactttaaga aggttctgga gaaggagaag aaacgtaaga 2040 agcgaagtga ggatgaatca gagacagaag atgaagagga gaaaagccaa gaggaccagg 2100 agcagaagag gaagagaagg aagactcgcc agccagatgc caaagatggg gattcatacg 2160 acccctatga cttcagtgac acagaggagg aaatgcctca agtacacact ccaaagacgg 2220 cagactcaca ggagaccaag gaatcccaga aagtggagtt gagtgaatcc aggttgaagg 2280 cattcaaggt ggccctcttg gatgtgttcc gggaagctca tgcgcagtca atcggcatga 2340 atcgcctcac agaatccatc aaccgggaca gcgaagagcc cttctcttca gttgagatcc 2400 aggctgctct gagcaagatg caggatgaca atcaggtcat ggtgtctgag ggcatcatct 2460 tcctcatctg aggaggcctc gtctctgaac ttgggttgtg ccgagagagt ttgttctgtg 2520 tttcccaccc tctccctgac ccaagtcttt gcctctactc ccttaacagt gttgaattca 2580 actgaaggcg aggaatgttg gtgatgaagc tgagttcagg actcggtgga ccctttggga 2640 atgggtcatg aaagctgcca tggggtgagg aaagaggaga cagtgggaga ggacaatgac 2700 tattgcatct tcattgcaaa agcactggct catccgccct acttcccatc ccacacaaac 2760 ccaattgtaa ataacatatg acttctgagt acttttgggg gcacaactgt tttctgtttg 2820 ctgttttttt gttttgtttt ttttctccag agcactttgg tctagactag gctttgggtg 2880 gttccaattg gtggagagaa gctctgaggc acgtcatgca ggtcaagaaa gctttctttg 2940 cagtagcacc agttaaggtg aatatgtatt gtatcacaaa acaaacccaa tatccagatg 3000 aatatccgag atgttgaata aacttagcca tttcgtacaa aaaaaggggg gcccggtaaa 3060 c 3061 <210> 48 <211> 3071 <212> DNA <213> Homo sapiens <400> 48 gaagttttcg cgccgcggtg gagtcatcct gggaacctcc acgcgacttt ggtggaggta 60 gttctttggc agcgggcatg gcgggtaccg tggtgctgga cgatgtggag ctgcgggagg 120 ctcagagaga ttacctggac ttcctggacg acgaggaaga ccagggaatt tatcagagca 180 aagttcggga gctgatcagt gacaaccaat accggctgat tgtcaatgtg aatgacctgc 240 gcaggaaaaa cgagaagagg gctaaccggc ttctgaacaa tgcctttgag gagctggttg 300 ccttccagcg ggccttaaag gattttgtgg cctccattga tgctacctat gccaagcagt 360 atgaggagtt ctacgtagga ctggaaggca gctttggctc caagcacgtc tccccgcgga 420 ctcttacctc ctgcttcctc agctgtgtgg tctgtgtgga gggcattgtc actaaatgtt 480 ctctagttcg tcccaaagtc gtccgcagtg tccactactg tcctgctact aagaagacca 540 tagagcgacg ttattctgat ctcaccaccc tggtggcctt tccctccagc tctgtctatc 600 ctaccaagga tgaggagaac aatccccttg agacagaata tggcctttct gtctacaagg 660 atcaccagac catcaccatc caggagatgc cggagaaggc cccagccggc cagctccccc 720 gctctgtgga cgtcattctg gatgatgact tggtggataa agcgaacgct ggtgaccggg 780 ttcaggtggt gggaacctac cgttgccttc ctggaaagaa gggaggctac acctctggga 840 ccttcaggac tgtcctgatt gcctgtaatg ttaagcagat gagcaaggat gctcagccct 900 ctttctctgc tgaggatata gccaagatca agaagttcag taaaacccga tccaaggata 960 tctttgacca gctggccaag tcattggccc caagtatcca tgggcatgac tatgtcaaga 1020 aagcaatcct ctgcttgctc ttgggagggg tggaacgaga cctagaaaat ggcagccaca 1080 tccgtgggga catcaatatt cttctaatag gagacccatc cgttgccaag tctcagcttc 1140 tgcggtatgt gctttgcact gcaccccgag ctatccccac cactggccgg ggctcctctg 1200 gagtgggtct gacggctgct gtcaccacag accaggaaac aggagagcgc cgtctggaag 1260 caggggccat ggtcctggct gaccgaggcg tggtttgcat tgatgaattt gacaaaatgt 1320 ctgacatgga tcgcacagcc atccatgaag tgatggagca gggtcgagtg accattgcca 1380 aggctggcat ccatgctcgg ctgaatgccc gctgcagtgt tttggcagct gccaaccctg 1440 tctacggcag gtatgaccag tataagactc caatggagaa cattgggcta caggactcac 1500 tgctgtcacg atttgacttg ctcttcatca tgctggatca gatggatcct gagcaggatc 1560 gggagatctc agaccatgtc cttcggatgc accgttacag agcacctggg gagcaggatg 1620 gcgatgctat gcccttgggt agtgctgtgg atatcctggc cacagatgat cccaacttta 1680 gccaggaaga tcagcaggac acccagattt atgagaagca tgacaacctt ctacatggga 1740 ccaagaagaa aaaggagaag atggtgagtg cagcattcat gaagaagtac atccatgtgg 1800 ccaaaatcat caagcctgtc ctgacacagg agtcggccac ctacattgca gaagagtatt 1860 cacgcctgcg cagccaggat agcatgagct cagacaccgc caggacatct ccagttacag 1920 cccgaacact ggaaactctg attcgactgg ccacagccca tgcgaaggcc cgcatgagca 1980 agactgtgga cctgcaggat gcagaggaag ctgtggagtt ggtccagtat gcttacttta 2040 agaaggttct ggagaaggag aagaaacgta agaagcgaag tgaggatgaa tcagagacag 2100 aagatgaaga ggagaaaagc caagaggacc aggagcagaa gaggaagaga aggaagactc 2160 gccagccaga tgccaaagat ggggattcat acgaccccta tgacttcagt gacacagagg 2220 aggaaatgcc tcaagtacac actccaaaga cggcagactc acaggagacc aaggaatccc 2280 agaaagtgga gttgagtgaa tccaggttga aggcattcaa ggtggccctc ttggatgtgt 2340 tccgggaagc tcatgcgcag tcaatcggca tgaatcgcct cacagaatcc atcaaccggg 2400 acagcgaaga gcccttctct tcagttgaga tccaggctgc tctgagcaag atgcaggatg 2460 acaatcaggt catggtgtct gagggcatca tcttcctcat ctgaggaggc ctcgtctctg 2520 aacttgggtt gtgccgagag agtttgttct gtgtttccca ccctctccct gaccaaagtc 2580 tttgcctcta ctcccttaac agtgttgaat tcaactgaag ccgaggaatg ttggtgatga 2640 agctgagttc aggactcggt ggaccctttg ggaatgggtc atgaaagctg ccatggggtg 2700 aggaaagagg agacagtggg agaggacaat gactattgca tcttcattgc aaaagcactg 2760 gctcatccgc cctacttccc atcccacaca aacccaattg taaataacat atgacttctg 2820 agtacttttg ggggcacaac tgttttctgt ttgctgtttt tttgttttgt tttttttctc 2880 cagagcactt tggtctagac taggctttgg gtggttccaa ttggtggaga gaagctctga 2940 ggcacgtcat gcaggtcaag aaagctttct ttgcagtagc accagttaag gtgaatatgt 3000 attgtatcac aaaacaaacc caatatccag atgaatatcc gagatgttga ataaacttag 3060 ccatttcgta c 3071 <210> 49 <211> 1024 <212> DNA <213> Homo sapiens <400> 49 gaaggacttc ctcctctgtg tcactgaagt cataggggtg tatgaatccc catcttggca 60 tctggctggc gagtcttcct tctcttcctc ttctgctcct ggtcctcttg gcttttctcc 120 tcttcatctt ctgtctctga ttcatcctca cttcgcttct tacgtttctt ctccttctcc 180 agaaccttct taaagtaagc atactggacc aactccacag cttccttcga tcctgcaggt 240 ccacagtctt gctcatgcgg gccttcgcat gggctgtggc cagtcgaatc agagtttcca 300 gtgttcgggc tgtaactgga gatggaattc cggatcaaga agatcatgca gacggacgaa 360 gagattggga aggtggcggc ggcggtgcct gtcatcatct cccgggcgct cgagctcttc 420 ctagagtcgc tgttgaagaa ggcctgccag gtgacccagt cgcggaacgc gaagaccatg 480 accacatccc acctgaagca gtgcatcgag ctggagcagc agtttgactt cttgaaggac 540 ctggtggcat ctgttcccga catgcagggg gacggggaag acaaccacat ggatggggac 600 aagggcgccc gcaggggccg gaagccaggc agcggcggcc ggaagaacgg tgggatggga 660 acgaaaagca aggacaagaa gctgtccggg acagactcgg agcaggagga tgaatctgag 720 gacacagata ctgatgggga agaggagaca tcacaacccc caccccaggc cagccacccc 780 tctgcccact ttcagagccc cccgacaccc ttcctgccct tcgcctctac tctgcctttg 840 cccccagcgc ccccgggccc ctcagcacct gatgaagagg acgaagaaga ttacgactcc 900 tagcgccttc tgccccccag accatagccc cttttagttg gtttttcatt cccgttgtta 960 tggagggcca catctgccag agcctggagt ctgcgaaggc cgggaccggt tccccggccc 1020 acag 1024 <210> 50 <211> 3533 <212> DNA <213> Homo sapiens <400> 50 gggtctcgcg gtttgggagc gctactcgcc aggtggactc ggagtccgcg agcgtcgtcg 60 gcaagcggcc gcctttccac ggtaaccgcg cgccggcggg gagggcgtgg cgcggagccg 120 acgggaacgt ccgcgctgcg gagcagggca gggaagccgg gaggcgggcc cggcccgagc 180 ttgtccttgt cgcgcaggta ctccgagcac tatgtcgtcc ccggcgtcga ccccgagccg 240 ccgcggcagc cggcgtggaa gggccacccc cgcccagacg cctcggagtg aggatgccag 300 gtcatctccc tctcagagac gtagaggcga ggattccacc tccacggggg agttgcagcc 360 gatgccaacc tcgcctggag tggacctgca gagccctgct gcgcaggacg tgctgttttc 420 cagccctccc caaatgcatt cttcagctat ccctcttgac tttgatgtta gttcaccact 480 gacatacggc actcccagct ctcgggtaga gggaacccca agaagtggtg ttaggggcac 540 acctgtgaga cagaggcctg acctgggctc tgcacagaag ggcctgcaag tggatctgca 600 gtctgacggg gcagcagcag aagatatagt ggcaagtgag cagtctctag gccaaaaact 660 tgtgatctgg ggaacagatg taaatgtggc agcatgcaaa gaaaactttc agagatttct 720 tcagcgtttt attgaccctc tggctaaaga agaagaaaat gttggcatag atattactga 780 acctctatac atgcaacgac ttggggagat taatgttatt ggtgagccat ttttaaatgt 840 gaactgtgaa cacatcaaat catttgacaa aaatttgtac agacaactca tctcttaccc 900 acaggaagtt attccaactt ttgacatggc tgtcaatgaa atcttctttg accgttaccc 960 tgactcaatc ttagaacatc agattcaagt aagaccattc aacgcattga agactaagaa 1020 tatgagaaac ctgaatccag aagacattga ccagctcatc accatcagcg gcatggtgat 1080 caggacatcc cagctgattc ccgagatgca ggaggccttc ttccagtgcc aagtgtgtgc 1140 ccacacgacc cgggtggaga tggaccgcgg ccgcattgca gagcccagtg tgtgcgggcg 1200 ctgccacacc acccacagca tggcactcat ccacaaccgc tccctcttct ctgacaagca 1260 gatgatcaag cttcaggagt ctccggaaga catgcctgca gggcagacac cacacacagt 1320 tatcctgttt gctcacaatg atctcgttga caaggtccag cctggggaca gagtgaatgt 1380 tacaggcatc tatcgagctg tgcctattcg agtcaatcca agagtgagta atgtgaagtc 1440 tgtctacaaa acccacattg atgtcattca ttatcggaaa acggatgcaa aacgtctgca 1500 tggccttgat gaagaagcag aacagaaact tttttcagag aaacgtgtgg aattgcttaa 1560 ggaactttcc aggaaaccag acatttatga gaggcttgct tcagccttgg ctccaagcat 1620 ttatgaacat gaagatataa agaagggaat tttgcttcag ctctttggcg ggacaaggaa 1680 ggattttagt cacactggaa ggggcaaatt tcgggctgag atcaacatct tgctgtgtgg 1740 cgaccctggt accagcaagt cccagctgct gcagtacgtg tacaacctcg tccccagggg 1800 ccagtacacg tctgggaagg gctccagtgc agttggcctc actgcgtacg taatgaaaga 1860 ccctgagaca aggcagctgg tcctgcagac aggtgctctt gtcctgagtg acaacggcat 1920 ctgctgtatc gatgagttcg acaagatgaa tgaaagtaca agatcggtat tgcatgaagt 1980 catggaacag cagactctgt ccattgcaaa ggctgggatc atctgtcagc tcaatgcgcg 2040 cacctctgtc ctggcagcag caaatcccat tgagtctcag tggaatccta aaaaaacaac 2100 cattgaaaac atccagctgc ctcatacttt attatcaagg tttgatttga tcttcctctt 2160 gctggaccct caggacgaag cctatgacag gcgtctggct caccacctgg tcgcactgta 2220 ctaccagagc gaggagcagg cagaggagga gctcctggac atggcggtgc taaaggacta 2280 cattgcctac gcgcacagca ccatcatgcc gcggctaagt gaggaagcca gccaggctct 2340 catcgaggct tatgtagaca tgaggaagat tggcagtagc cggggaatgg tttctgcata 2400 ccctcgacag ctagagtcat taatccgctt agcagaagcc catgctaaag taagattgtc 2460 taacaaagtt gaagccattg atgtggaaga ggccaaacgc ctccatcggg aagctctgaa 2520 gcagtctgca actgatcccc ggactggcat cgtggacata tctattctta ctacggggat 2580 gagtgccacc tctcgtaaac ggaaagaaga attagctgaa gcattgaaaa agcttatttt 2640 atctaagggc aaaacaccag ctctaaaata ccagcaactt tttgaagata ttcggggaca 2700 atctgacata gcaattacta aagatatgtt tgaagaagca ctgcgtgccc tggcagatga 2760 tgatttcctg acagtgactg ggaagaccgt gcgcttgctc tgaagccttg tgagcaagga 2820 aggctccctg catgtcctgc ttgctgcacg ccacatgggt gtggtctgca tctcagttgg 2880 ccgccatcag tgtaaataga gcttaaagtc atggtttggc tgcataaaaa ttttctaact 2940 tgggttcaat atttgtagtg aagtatctgt tttcattttt ttcacgttat aaataaaaat 3000 actatgctgg ccgggcgcgg tggctcacac ctgtaatccc agcactttgg gaggccaatg 3060 tgggtggatc atgaggtcag gagttcaaga ccagcctagc caagatggtg aaaccccgtc 3120 tctagtaaag ataacaaaaa attagctggg cttgatggca tgcgcctgta atcccagcta 3180 ctcgggaggt tgaggcagga gaatcgctta aacccaggcg gcagaggttg cagtgagcca 3240 agatcgcgcc actgcactcc agcctcagca atagagtgag actgtctcaa aaaaaaaaaa 3300 aaaaaaaaaa cctgccaatt ttcaaacata ccgtagagat tattttcagg tgccatttta 3360 tagtatagca gcagggcttt tactctgtgt atgcacagat gcagtctggg gcatggtttg 3420 tgtgctggac tttctcatgg ccatcatcag tatgcttatg gatttgatga caggcatagc 3480 ctgggcatat cacctcattg gtaaagggct agagcctttc ttttttatgg cac 3533 <210> 51 <211> 3249 <212> DNA <213> Homo sapiens <400> 51 cggagtccgc gagcgtcgtc ggcaagcggc cgcctttcca cggtaaccgc gcgccggcgg 60 ggagggcgtg gcgcggagcc gacgggaacg tccgcgctgc ggagcagggc agggaagccg 120 ggaggcgggc ccggcccgag cttgtccttg tcgcgcaggt actccgagca ctatgtcgtc 180 cccggcgtcg accccgagcc gccgcggcag ccggcgtgga agggccaccc ccgcccagac 240 gcctcggagt gaggatgcca ggtcatctcc ctctcagaga cgtagaggcg aggattccac 300 ctccacgggg gagttgcagc cgatgccaac ctcgcctgga gtggacctgc agagccctgc 360 tgcgcaggac gtgctgtttt ccagccctcc ccaaatgcat tcttcagcta tccctcttga 420 ctttgatgtt agttcaccac tgacatacgg cactcccagc tctcgggtag agggaacccc 480 aagaagtggt gttaggggca cacctgtgag acagaggcct gacctgggct ctgcacagaa 540 gggcctgcaa gtggatctgc agtctgacgg ggcagcagca gaagatatag tggcaagtga 600 gcagtctcta ggccaaaaac ttgtgatctg gggaacagat gtaaatgtgg cagcatgcaa 660 agaaaacttt cagagatttc ttcagcgttt tattgaccct ctggctaaag aagaagaaaa 720 tgttggcata gatattactg aacctctata catgcaacga cttggggaga ttaatgttat 780 tggtgagcca tttttaaatg tgaactgtga acacatcaaa tcatttgaca aaaatttgta 840 cagacaactc atctcttacc cacaggaagt tattccaact tttgacatgg ctgtcaatga 900 aatcttcttt gaccgttacc ctgactcaat cttagaacat cagattcaag taagaccatt 960 caacgcattg aagactaaga atatgagaaa cctgaatcca gaagacattg accagctcat 1020 caccatcagc ggcatggtga tcaggacatc ccagctgatt cccgagatgc aggaggcctt 1080 cttccagtgc caagtgtgtg cccacacgac ccgggtggag atggaccgcg gccgcattgc 1140 agagcccagt gtgtgcgggc gctgccacac cacccacagc atggcactca tccacaaccg 1200 ctccctcttc tctgacaagc agatgatcaa gcttcaggag tctccggaag acatgcctgc 1260 agggcagaca ccacacacag ttatcctgtt tgctcacaat gatctcgttg acaaggtcca 1320 gcctggggac agagtgaatg ttacaggcat ctatcgagct gtgcctattc gagtcaatcc 1380 aagagtgagt aatgtgaagt ctgtctacaa aacccacatt gatgtcattc attatcggaa 1440 aacggatgca aaacgtctgc atggccttga tgaagaagca gaacagaaac ttttttcaga 1500 gaaacgtgtg gaattgctta aggaactttc caggaaacca gacatttatg agaggcttgc 1560 ttcagccttg gctccaagca tttatgaaca tgaagatata aagaagggaa ttttgcttca 1620 gctctttggc gggacaagga aggattttag tcacactgga aggggcaaat ttcgggctga 1680 gatcaacatc ttgctgtgtg gcgaccctgg taccagcaag tcccagctgc tgcagtacgt 1740 gtacaacctc gtccccaggg gccagtacac gtctgggaag ggctccagtg cagttggcct 1800 cactgcgtac gtaatgaaag accctgagac aaggcagctg gtcctgcaga caggtgctct 1860 tgtcctgagt gacaacggca tctgctgtat cgatgagttc gacaagatga atgaaagtac 1920 aagatcggta ttgcatgaag tcatggaaca gcagactctg tccattgcaa aggctgggat 1980 catctgtcag ctcaatgcgc gcacctctgt cctggcagca gcaaatccca ttgagtctca 2040 gtggaatcct aaaaaaacaa ccattgaaaa catccagctg cctcatactt tattatcaag 2100 gtttgatttg atcttcctct tgctggaccc tcaggacgaa gcctatgaca ggcgtctggc 2160 tcaccacctg gtcgcactgt actaccagag cgaggagcag gcagaggagg agctcctgga 2220 catggcggtg ctaaaggact acattgccta cgcgcacagc accatcatgc cgcggctaag 2280 tgaggaagcc agccaggctc tcatcgaggc ttatgtagac atgaggaaga ttggcagtag 2340 ccggggaatg gtttctgcat accctcgaca gctagagtca ttaatccgct tagcagaagc 2400 ccatgctaaa gtaagattgt ctaacaaagt tgaagccatt gatgtggaag aggccaaacg 2460 cctccatcgg gaagctctga agcagtctgc aactgatccc cggactggca tcgtggacat 2520 atctattctt actacgggga tgagtgccac ctctcgtaaa cggaaagaag aattagctga 2580 agcattgaaa aagcttattt tatctaaggg caaaacacca gctctaaaat accagcaact 2640 ttttgaagat attcggggac aatctgacat agcaattact aaagatatgt ttgaagaagc 2700 actgcgtgcc ctggcagatg atgatttcct gacagtgact gggaagaccg tgcgcttgct 2760 ctgaagcctt gtgagcaagg aaggctccct gcatgtcctg cttgctgcac gccacatggg 2820 tgtggtctgc atctcagttg gccgccatca gtgtaaatag agcttaaagt catggtttgg 2880 ctgcataaaa attttctaac ttgggttcaa tatttgtagt gaagtatctg ttttcatttt 2940 tttcacgtta taaataaaaa tactatgctg gccgggcgcg gtggctcaca cctgtaatcc 3000 cagcactttg ggaggccaat gtgggtggat catgaggtca ggagttcaag accagcctag 3060 ccaagatggt gaaaccccgt ctctagtaaa gataacaaaa aattagctgg gcttgatggc 3120 atgcgcctgt aatcccagct actcgggagg ttgaggcagg agaatcgctt aaacccaggc 3180 ggcagaggtt gcagtgagcc aagatcgcgc cactgcactc cagcctcagc aatagagtga 3240 gactgtctc 3249 <210> 52 <211> 3273 <212> DNA <213> Homo sapiens <400> 52 gaattcggca cgagcgagtc gcgacgtcgt cggcaagcgg ccgccttcca cgtaacgcgc 60 gccggcgggg gagggcgttg gcgcggagcc gacgggaacg tccgcgctgc ggagcagggc 120 agggaagccg ggaggcgggc ccggcccgag cttgtccttg tcgcgcaggt actccgagca 180 ctatgtcgtc cccggcgtcg accccgagcc gccgcggcag ccggcgtgga agggccaccc 240 ccgcccagac gcctcggagt gaggatgcca ggtcatctcc ctctcagaga cgtagaggcg 300 aggattccac ctccacgggg gagttgcagc cgatgccaac ctcgcctgga gtggacctgc 360 agagcactgc tgcgcaggac gtgctgtttt ccagccctcc ccaaatgcat tcttcagcta 420 tccctcttga ctttgatgtt agttcaccac tgacatacgg cactcccagc tctcgggtag 480 agggaacccc aagaagtggt gttaggggca cacctgtgag acagaggcct gacctgggct 540 ctgcacagaa gggcctgcaa gtggatctgc agtctgacgg ggcagcagca gaagatatag 600 tggcaagtga gcagtctcta ggccaaaaac ttgtgatctg gggaacagat gtaaatgtgg 660 cagcatgcaa agaaaacttt cagagatttc ttcagcgttt tattgaccct ctggctaaag 720 aagaagaaaa tgttggcata gatattactg aacctctata catgcaacga cttggggaga 780 ttaatgttat tggtgagcaa tttttaaatg tgaactgtga acacatcaaa tcatttgaca 840 aaaatttgta cagacaactc atctcttacc cacaggaagt tattccaact tttgacatgg 900 ctgtcaatga aatcttcttt gaccgttacc ctgactcaat cttagaacat cagattcaag 960 taagaccatt caacgcattg aagactaaga atatgagaaa cctgaatcca gaagacattg 1020 accagctcat caccatcagc ggcatggtga tcaggacatc ccagctgatt cccgagatgc 1080 aggaggcctt cttccagtgc caagtgtgtg cccacacgac ccgggtggag atggaccgcg 1140 gccgcattgc agagcccagt gtgtgcgggc gctgccacac cacccacagc atggcactca 1200 tccacaaccg ctccctcttc tctgacaagc agatgatcaa gcttcaggag tctccggaag 1260 acatgcctgc agggcagaca ccacacacag ttatcctgtt tgctcacaat gatctcgttg 1320 acaaggtcca gcctggggac agagtgaatg ttacaggcat ctatcgagct gtgcctattc 1380 gagtcaatcc aagagtgagt aatgtgaagt ctgtctacaa aacccacatt gatgtcattc 1440 attatcggaa aacggatgca aaacgtctgc atggccttga tgaagaagca gaacagaaac 1500 ttttttcaga gaaacgtgtg gaattgctta aggaactttc caggaaacca gacatttatg 1560 agaggcttgc ttcagccttg gctccaagca tttatgaaca tgaagatata aagaagggaa 1620 ttttgcttca gctctttggc gggacaagga aggattttag tcacactgga aggggcaaat 1680 ttcgggctga gatcaacatc ttgctgtgtg gcgaccctgg taccagcaag tcccagctgc 1740 tgcagtacgt gtacaacctc gtccccaggg gccagtacac gtctgggaag ggctccagtg 1800 cagttggcct cactgcgtac gtaatgaaag accctgagac aaggcagctg gtcctgcaga 1860 caggtgctct tgtcctgagt gacaacggca tctgctgtat cgatgagttc gacaagatga 1920 atgaaagtac aagatcggta ttgcatgaag tcatggaaca gcagactctg tccattgcaa 1980 aggctgggat catctgtcag ctcaatgcgc gcacctctgt cctggcagca gcaaatccca 2040 ttgagtctca gtggaatcct aaaaaaacaa ccattgaaaa catccagctg cctcatactt 2100 tattatcaag gtttgatttg atcttcctca tgctggaccc tcaggacgaa gcctatgaca 2160 ggcgtctggc tcaccacctg gtcgcactgt actaccagag cgaggagcag gcagaggagg 2220 agctcctgga catggcggtg ctaaaggact acattgccta cgcgcacagc accatcatgc 2280 cgcggctaag tgaggaagcc agccaggctc tcatcgaggc ttatgtagac atgaggaaga 2340 ttggcagtag ccggggaatg gtttctgcat accctcgaca gctagagtca ttaatccgct 2400 tagcagaagc ccatgctaaa gtaagattgt ctaacaaagt tgaagccatt gatgtggaag 2460 aggccaaacg cctccatcgg gaagctctga agcagtctgc aactgatccc cggactggca 2520 tcgtggacat atctattctt actacgggga tgagtgccac ctctcgtaaa cggaaagaag 2580 aattagctga agcattgaaa aagcttattt tatctaaggg caaaacacca gctctaaaat 2640 accagcaact ttttgaagat attcggggac aatctgacat agcaattact aaagatatgt 2700 ttgaagaagc actgcgtgcc ctggcagatg atgatttcct gacagtgact gggaagaccg 2760 tgcgcttgct ctgaagcctt gtgagcaagg aaggctccct gcatgtcatg caattctgca 2820 cgccacatgg gtgtggtcat gcaatcatca gttggccgcc atcagtgtaa atagagctta 2880 aagtcatggt ttggctgcat aaaaaatttt ctaacttggg ttcaatattt gtagtgaagt 2940 atctgttttc atttttttca cgttataaat aaaaatacta tgctggccgg gcgcggtggc 3000 tcacacctgt aatcccagca ctttgggagg ccaatgtggg tggatcatga ggtcaggagt 3060 tcaagaccag cctagccaag atggtgaaac cccgtctcta gtaaagataa caaaaaatta 3120 gctgggcttg atggcatgcg cctgtaatcc cagctactcg ggaggttgag gcaggagatc 3180 gcttaaaccc aggcggcaga ggttgcagtg agccaagatc gcgccactgc actccagcct 3240 cagcaataga gtgagactgt ctcaaaaaaa aaa 3273 <210> 53 <211> 3417 <212> DNA <213> Homo sapiens <400> 53 gggtctcgcg gtttgggagc gctactcgcc aggtggactc ggagtccgcg agcgtcgtcg 60 gcaagcggcc gcctttccac ggtactccga gcactatgtc gtccccggcg tcgaccccga 120 gccgccgcgg cagccggcgt ggaagggcca cccccgccca gacgcctcgg agtgaggatg 180 ccaggtcatc tccctctcag agacgtagag gcgaggattc cacctccacg ggggagttgc 240 agccgatgcc aacctcgcct ggagtggacc tgcagagccc tgctgcgcag gacgtgctgt 300 tttccagccc tccccaaatg cattcttcag ctatccctct tgactttgat gttagttcac 360 cactgacata cggcactccc agctctcggg tagagggaac cccaagaagt ggtgttaggg 420 gcacacctgt gagacagagg cctgacctgg gctctgcaca gaagggcctg caagtggatc 480 tgcagtctga cggggcagca gcagaagata tagtggcaag tgagcagtct ctaggccaaa 540 aacttgtgat ctggggaaca gatgtaaatg tggcagcatg caaagaaaac tttcagagat 600 ttcttcagcg ttttattgac cctctggcta aagaagaaga aaatgttggc atagatatta 660 ctgaacctct atacatgcaa cgacttgggg agattaatgt tattggtgag ccatttttaa 720 atgtgaactg tgaacacatc aaatcatttg acaaaaattt gtacagacaa ctcatctctt 780 acccacagga agttattcca acttttgaca tggctgtcaa tgaaatcttc tttgaccgtt 840 accctgactc aatcttagaa catcagattc aagtaagacc attcaacgca ttgaagacta 900 agaatatgag aaacctgaat ccagaagaca ttgaccagct catcaccatc agcggcatgg 960 tgatcaggac atcccagctg attcccgaga tgcaggaggc cttcttccag tgccaagtgt 1020 gtgcccacac gacccgggtg gagatggacc gcggccgcat tgcagagccc agtgtgtgcg 1080 ggcgctgcca caccacccac agcatggcac tcatccacaa ccgctccctc ttctctgaca 1140 agcagatgat caagcttcag gagtctccgg aagacatgcc tgcagggcag acaccacaca 1200 cagttatcct gtttgctcac aatgatctcg ttgacaaggt ccagcctggg gacagagtga 1260 atgttacagg catctatcga gctgtgccta ttcgagtcaa tccaagagtg agtaatgtga 1320 agtctgtcta caaaacccac attgatgtca ttcattatcg gaaaacggat gcaaaacgtc 1380 tgcatggcct tgatgaagaa gcagaacaga aacttttttc agagaaacgt gtggaattgc 1440 ttaaggaact ttccaggaaa ccagacattt atgagaggct tgcttcagcc ttggctccaa 1500 gcatttatga acatgaagat ataaagaagg gaattttgct tcagctcttt ggcgggacaa 1560 ggaaggattt tagtcacact ggaaggggca aatttcgggc tgagatcaac atcttgctgt 1620 gtggcgaccc tggtaccagc aagtcccagc tgctgcagta cgtgtacaac ctcgtcccca 1680 ggggccagta cacgtctggg aagggctcca gtgcagttgg cctcactgcg tacgtaatga 1740 aagaccctga gacaaggcag ctggtcctgc agacaggtgc tcttgtcctg agtgacaacg 1800 gcatctgctg tatcgatgag ttcgacaaga tgaatgaaag tacaagatcg gtattgcatg 1860 aagtcatgga acagcagact ctgtccattg caaaggctgg gatcatctgt cagctcaatg 1920 cgcgcacctc tgtcctggca gcagcaaatc ccattgagtc tcagtggaat cctaaaaaaa 1980 caaccattga aaacatccag ctgcctcata ctttattatc aaggtttgat ttgatcttcc 2040 tcttgctgga ccctcaggac gaagcctatg acaggcgtct ggctcaccac ctggtcgcac 2100 tgtactacca gagcgaggag caggcagagg aggagctcct ggacatggcg gtgctaaagg 2160 actacattgc ctacgcgcac agcaccatca tgccgcggct aagtgaggaa gccagccagg 2220 ctctcatcga ggcttatgta gacatgagga agattggcag tagccgggga atggtttctg 2280 cataccctcg acagctagag tcattaatcc gcttagcaga agcccatgct aaagtaagat 2340 tgtctaacaa agttgaagcc attgatgtgg aagaggccaa acgcctccat cgggaagctc 2400 tgaagcagtc tgcaactgat ccccggactg gcatcgtgga catatctatt cttactacgg 2460 ggatgagtgc cacctctcgt aaacggaaag aagaattagc tgaagcattg aaaaagctta 2520 ttttatctaa gggcaaaaca ccagctctaa aataccagca actttttgaa gatattcggg 2580 gacaatctga catagcaatt actaaagata tgtttgaaga agcactgcgt gccctggcag 2640 atgatgattt cctgacagtg actgggaaga ccgtgcgctt gctctgaagc cttgtgagca 2700 aggaaggctc cctgcatgtc ctgcttgctg cacgccacat gggtgtggtc tgcatctcag 2760 ttggccgcca tcagtgtaaa tagagcttaa agtcatggtt tggctgcata aaaattttct 2820 aacttgggtt caatatttgt agtgaagtat ctgttttcat ttttttcacg ttataaataa 2880 aaatactatg ctggccgggc gcggtggctc acacctgtaa tcccagcact ttgggaggcc 2940 aatgtgggtg gatcatgagg tcaggagttc aagaccagcc tagccaagat ggtgaaaccc 3000 cgtctctagt aaagataaca aaaaattagc tgggcttgat ggcatgcgcc tgtaatccca 3060 gctactcggg aggttgaggc aggagaatcg cttaaaccca ggcggcagag gttgcagtga 3120 gccaagatcg cgccactgca ctccagcctc agcaatagag tgagactgtc tcaaaaaaaa 3180 aaaaaaaaaa aaaacctgcc aattttcaaa cataccgtag agattatttt caggtgccat 3240 tttatagtat agcagcaggg cttttactct gtgtatgcac agatgcagtc tggggcatgg 3300 tttgtgtgct ggactttctc atggccatca tcagtatgct tatggatttg atgacaggca 3360 tagcctgggc atatcacctc attggtaaag ggctagagcc tttctttttt atggcac 3417 <210> 54 <211> 2851 <212> DNA <213> Homo sapiens <400> 54 gggagccgac gggaacgtcc gcgctgcgga gcagggcagg gaagccggga ggcgggcccg 60 gcccgagctt gtccttgtcg cgcaggtact ccgagcacta tgtcgtcccc ggcgtcgacc 120 ccgagccgcc gcggcagccg gcgtggaagg gccacccccg cccagacgcc tcggagtgag 180 gatgccaggt catctccctc tcagagacgt agaggcgagg attccacctc cacgggggag 240 ttgcagccga tgccaacctc gcctggagtg gacctgcaga gccctgctgc gcaggacgtg 300 ctgttttcca gccctcccca aatgcattct tcagctatcc ctcttgactt tgatgttagt 360 tcaccactga catacggcac tcccagctct cgggtagagg gaaccccaag aagtggtgtt 420 aggggcacac ctgtgagaca gaggcctgac ctgggctctg cacagaaggg cctgcaagtg 480 gatctgcagt ctgacggggc agcagcagaa gatatagtgg caagtgagca gtctctaggc 540 caaaaacttg tgatctgggg aacagatgta aatgtggcag catgcaaaga aaactttcag 600 agatttcttc agcgttttat tgaccctctg gctaaagaag aagaaaatgt tggcatagat 660 attactgaac ctctatacat gcaacgactt ggggagatta atgttattgg tgagccattt 720 ttaaatgtga actgtgaaca catcaaatca tttgacaaaa atttgtacag acaactcatc 780 tcttacccac aggaagttat tccaactttt gacatggctg tcaatgaaat cttctttgac 840 cgttaccctg actcaatctt agaacatcag attcaagtaa gaccattcaa cgcattgaag 900 actaagaata tgagaaacct gaatccagaa gacattgacc agctcatcac catcagcggc 960 atggtgatca ggacatccca gctgattccc gagatgcagg aggccttctt ccagtgccaa 1020 gtgtgtgccc acacgacccg ggtggagatg gaccgcggcc gcattgcaga gcccagtgtg 1080 tgcgggcgct gccacaccac ccacagcatg gcactcatcc acaaccgctc cctcttctct 1140 gacaagcaga tgatcaagct tcaggagtct ccggaagaca tgcctgcagg gcagacacca 1200 cacacagtta tcctgtttgc tcacaatgat ctcgttgaca aggtccagcc tggggacaga 1260 gtgaatgtta caggcatcta tcgagctgtg cctattcgag tcaatccaag agtgagtaat 1320 gtgaagtctg tctacaaaac ccacattgat gtcattcatt atcggaaaac ggatgcaaaa 1380 cgtctgcatg gccttgatga agaagcagaa cagaaacttt tttcagagaa acgtgtggaa 1440 ttgcttaagg aactttccag gaaaccagac atttatgaga ggcttgcttc agccttggct 1500 ccaagcattt atgaacatga agatataaag aagggaattt tgcttcagct ctttggcggg 1560 acaaggaagg attttagtca cactggaagg ggcaaatttc gggctgagat caacatcttg 1620 ctgtgtggcg accctggtac cagcaagtcc cagctgctgc agtacgtgta caacctcgtc 1680 cccaggggcc agtacacgtc tgggaagggc tccagtgcag ttggcctcac tgcgtacgta 1740 atgaaagacc ctgagacaag gcagctggtc ctgcagacag gtgctcttgt cctgagtgac 1800 aacggcatct gctgtatcga tgagttcgac aagatgaatg aaagtacaag atcggtattg 1860 catgaagtca tggaacagca gactctgtcc attgcaaagg ctgggatcat ctgtcagctc 1920 aatgcgcgca cctctgtcct ggcagcagca aatcccattg agtctcagtg gaatcctaaa 1980 aaaacaacca ttgaaaacat ccagctgcct catactttat tatcaaggtt tgatttgatc 2040 ttcctcatgc tggaccctca ggacgaagcc tatgacaggc gtctggctca ccacctggtc 2100 gcactgtact accagagcga ggagcaggca gaggaggagc tcctggacat ggcggtgcta 2160 aaggactaca ttgcctacgc gcacagcacc atcatgccgc ggctaagtga ggaagccagc 2220 caggctctca tcgaggctta tgtagacatg aggaagattg gcagtagccg gggaatggtt 2280 tctgcatacc ctcgacagct agagtcatta atccgcttag cagaagccca tgctaaagta 2340 agattgtcta acaaagttga agccattgat gtggaagagg ccaaacgcct ccatcgggaa 2400 gctctgaagc agtctgcaac tgatccccgg actggcatcg tggacatatc tattcttact 2460 acggggatga gtgccacctc tcgtaaacgg aaagaagaat tagctgaagc attgaaaaag 2520 cttattttat ctaagggcaa aacaccagct ctaaaatacc agcaactttt tgaagatatt 2580 cggggacaat ctgacatagc aattactaaa gatatgtttg aagaagcact gcgtgccctg 2640 gcagatgatg atttcctgac agtgactggg aagaccgtgc gcttgctctg aagccttgtg 2700 agcaaggaag gctccctgca tgtcctgctt gctgcacgcc acatgggtgt ggtctgcatc 2760 tcagttggcc gccatcagtg taaatagagc ttaaagtcat ggtttggctg cataaaaatt 2820 ttctaacttg ggttcaaaaa aaaaaaaaaa a 2851 <210> 55 <211> 2860 <212> DNA <213> Homo sapiens <400> 55 ggagtccgcg agcgtcgtcg gcaagcggcc gcctttccac ggtactccga gcactatgtc 60 gtccccggcg tcgaccccga gccgccgcgg cagccggcgt ggaagggcca cccccgccca 120 gacgcctcgg agtgaggatg ccaggtcatc tccctctcag agacgtagag gcgaggattc 180 cacctccacg ggggagttgc agccgatgcc aacctcgcct ggagtggacc tgcagagccc 240 tgctgcgcag gacgtgctgt tttccagccc tccccaaatg cattcttcag ctatccctct 300 tgactttgat gttagttcac cactgacata cggcactccc agctctcggg tagagggaac 360 cccaagaagt ggtgttaggg gcacacctgt gagacagagg cctgacctgg gctctgcaca 420 gaagggcctg caagtggatc tgcagtctga cggggcagca gcagaagata tagtggcaag 480 tgagcagtct ctaggccaaa aacttgtgat ctggggaaca gatgtaaatg tggcagcatg 540 caaagaaaac tttcagagat ttcttcagcg ttttattgac cctctggcta aagaagaaga 600 aaatgttggc atagatatta ctgaacctct atacatgcaa cgacttgggg agattaatgt 660 tattggtgag ccatttttaa atgtgaactg tgaacacatc aaatcatttg acaaaaattt 720 gtacagacaa ctcatctctt acccacagga agttattcca acttttgaca tggctgtcaa 780 tgaaatcttc tttgaccgtt accctgactc aatcttagaa catcagattc aagtaagacc 840 attcaacgca ttgaagacta agaatatgag aaacctgaat ccagaagaca ttgaccagct 900 catcaccatc agcggcatgg tgatcaggac atcccagctg attcccgaga tgcaggaggc 960 cttcttccag tgccaagtgt gtgcccacac gacccgggtg gagatggacc gcggccgcat 1020 tgcagagccc agtgtgtgcg ggcgctgcca caccacccac agcatggcac tcatccacaa 1080 ccgctccctc ttctctgaca agcagatgat caagcttcag gagtctccgg aagacatgcc 1140 tgcagggcag acaccacaca cagttatcct gtttgctcac aatgatctcg ttgacaaggt 1200 ccagcctggg gacagagtga atgttacagg catctatcga gctgtgccta ttcgagtcaa 1260 tccaagagtg agtaatgtga agtctgtcta caaaacccac attgatgtca ttcattatcg 1320 gaaaacggat gcaaaacgtc tgcatggcct tgatgaagaa gcagaacaga aacttttttc 1380 agagaaacgt gtggaattgc ttaaggaact ttccaggaaa ccagacattt atgagaggct 1440 tgcttcagcc ttggctccaa gcatttatga acatgaagat ataaagaagg gaattttgct 1500 tcagctcttt ggcgggacaa ggaaggattt tagtcacact ggaaggggca aatttcgggc 1560 tgagatcaac atcttgctgt gtggcgaccc tggtaccagc aagtcccagc tgctgcagta 1620 cgtgtacaac ctcgtcccca ggggccagta cacgtctggg aagggctcca gtgcagttgg 1680 cctcactgcg tacgtaatga aagaccctga gacaaggcag ctggtcctgc agacaggtgc 1740 tcttgtcctg agtgacaacg gcatctgctg tatcgatgag ttcgacagga tgaatgaaag 1800 tacaagatcg gtattgcatg aagtcatgga acagcagact ctgtccattg caaaggctgg 1860 gatcatctgt cagctcaatg cgcgcacctc tgtcctggca gcagcaaatc ccattgagtc 1920 tcagtggaat cctaaaaaaa caaccattga aaacatccag ctgcctcata ctttattatc 1980 aaggtttgat ttgatcttcc tcatgctgga ccctcaggac gaagcctatg acaggcgtct 2040 ggctcaccac ctggtcgcac tgtactacca gagcgaggag caggcagagg aggagctcct 2100 ggacatggcg gtgctaaagg actacattgc ctacgcgcac agcaccatca tgccgcggct 2160 aagtgaggaa gccagccagg ctctcatcga ggcttatgta gacatgagga agattggcag 2220 tagccgggga atggtttctg cataccctcg acagctagag tcattaatcc gcttagcaga 2280 agcccatgct aaagtaagat tgtctaacaa agttgaagcc attgatgtgg aagaggccaa 2340 acgcctccat cgggaagctc tgaagcagtc tgcaactgat ccccggactg gcatcgtgga 2400 catatctatt cttactacgg ggatgagtgc cacctctcgt aaacggaaag aagaattagc 2460 tgaagcattg aaaaagctta ttttatctaa gggcaaaaca ccagctctaa aataccagca 2520 actttttgaa gatattcggg gacaatctga catagcaatt actaaagata tgtttgaaga 2580 agcactgcgt gccctggcag atgatgattt cctgacagtg actgggaaga ccgtgcgctt 2640 gctctgaagc cttgtgagca aggaaggctc cctgcatgtc ctgcttgctg cacgccacat 2700 gggtgtggtc tgcatctcag ttggccgcca tcagtgtaaa tagagcttaa agtcatggtt 2760 tggctgcata aaaattttct aacttgggtt caatatttgt agtgaagtat ctgttttcat 2820 ttttttcacg ttataaataa aaatactatg ctggccgggc 2860 <210> 56 <211> 2548 <212> DNA <213> Homo sapiens <400> 56 ttttcccgcg aaactcggcg gctgagcgtg gaggttcttg tctcccctgg tttgtgaagt 60 gcggaaaacc agaggcgcag tcatgtcggg attcgacgat cctggcattt tctacagcga 120 cagcttcggg ggcgacgccc aggccgacga ggggcaggcc cgcaaatcgc agctgcagag 180 gcgcttcaag gagttcctgc ggcagtaccg agtgggcacc gaccgcacgg gcttcacctt 240 caaatacagg gatgaactca agcggcatta caacctgggg gagtactgga ttgaggtgga 300 gatggaggat ctggccagct ttgatgagga cctggccgac tacttgtaca agcagccagc 360 cgagcacctg cagctgctgg aggaagctgc caaggaggta gctgatgagg tgacccggcc 420 ccggccttct ggggaggagg tgctccagga catccaggtc atgctcaagt cggacgccag 480 cccttccagc attcgtagcc tgaagtcgga catgatgtca cacctggtga agatccctgg 540 catcatcatc gcggcctctg cggtccgtgc caaggccacc cgcatctcta tccagtgccg 600 cagctgccgc aacaccctca ccaacattgc catgcgccct ggcctcgagg gctatgccct 660 gcccaggaag tgcaacacag atcaggctgg gcgccccaaa tgcccattgg acccgtactt 720 catcatgccc gacaaatgca aatgcgtgga cttccagacc ctgaagctgc aggagctgcc 780 tgatgcagtc ccccacgggg agatgcccag acacatgcag ctctactgcg acaggtacct 840 gtgtgacaag gtcgtccctg ggaacagggt taccatcatg ggcatctact ccatcaagaa 900 gtttggcctg actaccagca ggggccgtga cagggtgggc gtgggcatcc gaagctccta 960 catccgtgtc ctgggcatcc aggtggacac agatggctct ggccgcagct ttgctggggc 1020 cgtgagcccc caggaggagg aggagttccg tcgcctggct gccctcccaa atgtctatga 1080 ggtcatctcc aagagcatcg ccccctccat ctttgggggc acagacatga agaaggccat 1140 tgcctgcctg ctctttgggg gctcccgaaa gaggctccct gatggactta ctcgccgagg 1200 agacatcaac ctgctgatgc taggggaccc tgggacagcc aagtcccagc ttctgaagtt 1260 tgtggagaag tgttctccca ttggggtata cacgtctggg aaaggcagca gcgcagctgg 1320 actgacagcc tcggtgatga gggacccttc gtcccggaat ttcatcatgg agggcggagc 1380 catggtcctg gccgatggtg gggtcgtctg tattgacgag tttgacaaga tgcgagaaga 1440 tgaccgtgtg gcaatccacg aagccatgga gcagcagacc atctctatcg ccaaggctgg 1500 gatcaccacc accctgaact cccgctgctc cgtcctggct gctgccaact cagtgttcgg 1560 ccgctgggat gagacgaagg gggaggacaa cattgacttc atgcccacca tcttgtcgcg 1620 cttcgacatg atcttcatcg tcaaggatga gcacaatgag gagagggatg tgatgctggc 1680 caagcatgtc atcactctgc acgtgagcgc actgacacag acacaggctg tggagggcga 1740 gattgacctg gccaagctga agaagtttat tgcctactgc cgagtgaagt gtggcccccg 1800 gctgtcagca gaggctgcag agaaactgaa gaaccgctac atcatcatgc ggagcggggc 1860 ccgtcagcac gagagggaca gtgaccgccg ctccagcatc cccatcactg tgcggcagct 1920 ggaggccatt gtgcgcatcg cggaagccct cagcaagatg aagctgcagc ccttcgccac 1980 agaggcagat gtggaggagg ccctgcggct cttccaagtg tccacgttgg atgctgcctt 2040 gtccggtacc ctgtcagggg tggagggctt caccagccag gaggaccagg agatgctgag 2100 ccgcatcgag aagcagctca agcgccgctt tgccattggc tcccaggtgt ctgagcacag 2160 catcatcaag gacttcacca agcagaaata cccggagcac gccatccaca aggtgctgca 2220 gctcatgctg cggcgcggcg agatccagca tcgcatgcag cgcaaggttc tctaccgcct 2280 caagtgagtc gcgccgcctc actggactca tggactcgcc cacgcctcgc ccctcctgcc 2340 gctgcctgcc attgacaatg ttgctgggac ctctgcctcc ccactgcagc cctcgaactt 2400 cccaggcacc ctcctttctg ccccagagga aggagctgta gtgtcctgct gcctctgggc 2460 gcccgcctct agcgcggttc tgggaagtgt gcttttggca tccgttaata ataaagccac 2520 ggtgtgttca ggtaaaaaaa aaaaaaaa 2548 <210> 57 <211> 2496 <212> DNA <213> Homo sapiens <400> 57 gcggaaaacc agaggcgcag tcatgtcggg attcgacgat cctggcattt tctacagcga 60 cagcttcggg ggcgacgccc aggccgacga ggggcaggcc cgcaaatcgc agctgcagag 120 gcgcttcaag gagttcctgc ggcagtaccg agtgggcacc gaccgcacgg gcttcacctt 180 caaatacagg gatgaactca agcggcatta caacctgggg gagtactgga ttgaggtgga 240 gatggaggat ctggccagct ttgatgagga cctggccgac tacttgtaca agcagccagc 300 cgagcacctg cagctgctgg aggaagctgc caaggaggta gctgatgagg tgacccggcc 360 ccggccttct ggggaggagg tgctccagga catccaggtc atgctcaagt cggacgccag 420 cccttccagc attcgtagcc tgaagtcgga catgatgtca cacctggtga agatccctgg 480 catcatcatc gcggcctctg cggtccgtgc caaggccacc cgcatctcta tccagtgccg 540 cagctgccgc aacaccctca ccaacattgc catgcgccct ggcctcgagg gctatgccct 600 gcccaggaag tgcaacacag atcaggctgg gcgccccaaa tgcccattgg acccgtactt 660 catcatgccc gacaaatgca aatgcgtgga cttccagacc ctgaagctgc aggagctgcc 720 tgatgcagtc ccccacgggg agatgcccag acacatgcag ctctactgcg acaggtacct 780 gtgtgacaag gtcgtccctg ggaacagggt taccatcatg ggcatctact ccatcaagaa 840 gtttggcctg actaccagca ggggccgtga cagggtgggc gtgggcatcc gaagctccta 900 catccgtgtc ctgggcatcc aggtggacac agatggctct ggccgcagct ttgctggggc 960 cgtgagcccc caggaggagg aggagttccg tcgcctggct gccctcccaa atgtctatga 1020 ggtcatctcc aagagcatcg ccccctccat ctttgggggc acagacatga agaaggccat 1080 tgcctgcctg ctctttgggg gctcccgaaa gaggctccct gatggactta ctcgccgagg 1140 agacatcaac ctgctgatgc taggggaccc tgggacagcc aagtcccagc ttctgaagtt 1200 tgtggagaag tgttctccca ttggggtata cacgtctggg aaaggcagca gcgcagctgg 1260 actgacagcc tcggtgatga gggacccttc gtcccggaat ttcatcatgg agggcggagc 1320 catggtcctg gccgatggtg gggtcgtctg tattgacgag tttgacaaga tgcgagaaga 1380 tgaccgtgtg gcaatccacg aagccatgga gcagcagacc atctctatcg ccaaggctgg 1440 gatcaccacc accctgaact cccgctgctc cgtcctggct gctgccaact cagtgttcgg 1500 ccgctgggat gagacgaagg gggaggacaa cattgacttc atgcccacca tcttgtcgcg 1560 cttcgacatg atcttcatcg tcaaggatga gcacaatgag gagagggatg tgatgctggc 1620 caagcatgtc atcactctgc acgtgagcgc actgacacag acacaggctg tggagggcga 1680 gattgacctg gccaagctga agaagtttat tgcctactgc cgagtgaagt gtggcccccg 1740 gctgtcagca gaggctgcag agaaactgaa gaaccgctac atcatcatgc ggagcggggc 1800 ccgtcagcac gagagggaca gtgaccgccg ctccagcatc cccatcactg tgcggcagct 1860 ggaggccatt gtgcgcatcg cggaagccct cagcaagatg aagctgcagc ccttcgccac 1920 agaggcagat gtggaggagg ccctgcggct cttccaagtg tccacgttgg atgctgcctt 1980 gtccggtacc ctgtcagggg tggagggctt caccagccag gaggaccagg agatgctgag 2040 ccgcatcgag aagcagctca agcgccgctt tgccattggc tcccaggtgt ctgagcacag 2100 catcatcaag gacttcacca agcagaaata cccggagcac gccatccaca aggtgctgca 2160 gctcatgctg cggcgcggcg agatccagca tcgcatgcag cgcaaggttc tctaccgcct 2220 caagtgagtc gcgccgcctc actggactca tggactcgcc cacgcctcgc ccctcctgcc 2280 gctgcctgcc attgacaatg ttgctgggac ctctgcctcc ccactgcagc cctcgaactt 2340 cccaggcacc ctcctttctg ccccagagga aggagctgta gtgtcctgct gcctctgggc 2400 gcccgcctct agcgcggttc tgggaagtgt gcttttggca tccgttaata ataaagccac 2460 ggtgtgttca ggtaaaaaaa aaaaaaaaaa aaaaaa 2496 <210> 58 <211> 2534 <212> DNA <213> Homo sapiens <400> 58 ggaaaaccag aggcgcagtc atgtcgggat tcgacgatcc tggcattttc tacagcgaca 60 gcttcggggg cgacgcccag gccgacgagg ggcaggcccg caaatcgcag ctgcagaggc 120 gcttcaagga gttcctgcgg cggtaccgag tgggcaccga ccgcacgggc ttcaccttca 180 aatacaggga tgaactcaag cggcattaca acctggggga gtactggatt gaggtggaga 240 tggaggatct ggccagcttt gatgaggacc tggccgacta cttgtacaag cagccagccg 300 agcacctgca gctgctggag gaagctgcca aggaggtagc tgatgaggtg acccggcccc 360 ggccttctgg ggaggaggtg ctccaggaca tccaggtcat gctcaagtcg gacgccagcc 420 cttccagcat tcgtagcctg aagtcggaca tgatgtcaca cctggtgaag atccctggca 480 tcatcatcgc ggcctctgcg gtccgtgcca aggccacccg catctctatc cagtgccgca 540 gctgccgcaa caccctcacc aacattgcca tgcgccctgg cctcgagggc tatgccctgc 600 ccaggaagtg caacacagat caggctgggc gccccaaatg cccattggac ccgtacttca 660 tcatgcccga caaatgcaaa tgcgtggact tccagaccct gaagctgcag gagctgcctg 720 atgcagtccc ccacggggag atgcccagac acatgcagct ctactgcgac aggtacctgt 780 gtgacaaggt cgtccctggg aacagggtta ccatcatggg catctactcc atcaagaagt 840 ttggcctgac taccagcagg ggccgtgaca gggtgggcgt gggcatccga agctcctaca 900 tccgtgtcct gggcatccag gtggacacag atggctctgg ccgcagcttt gctggggccg 960 tgagccccca ggaggaggag gagttccgtc gcctggctgc cctcccaaat gtctatgagg 1020 tcatctccaa gagcatcgcc ccctccatct ttgggggcac agacatgaag aaggccattg 1080 cctgcctgct ctttgggggc tcccgaaaga ggctccctga tggacttact cgccgaggag 1140 acatcaacct gctgatgcta ggggaccctg ggacagccaa gtcccagctt ctgaagtttg 1200 tggagaagtg ttctcccatt ggggtataca cgtctgggaa aggcagcagc gcagctggac 1260 tgacagcctc ggtgatgagg gacccttcgt cccggaattt catcatggag ggcggagcca 1320 tggtcctggc cgatggtggg gtcgtctgta ttgacgagtt tgacaagatg cgagaagatg 1380 accgtgtggc aatccacgaa gccatggagc agcagaccat ctctatcgcc aaggctggga 1440 tcaccaccac cctgaactcc cgctgctccg tcctggctgc tgccaactca gtgttcggcc 1500 gctgggatga gacgaagggg gaggacaaca ttgacttcat gcccaccatc ttgtcgcgct 1560 tcgacatgat cttcatcgtc aaggatgagc acaatgagga gagggatgtg atgctggcca 1620 agcatgtcat cactctgcac gtgagcgcac tgacacagac acaggctgtg gagggcgaga 1680 ttgacctggc caagctgaag aagtttattg cctactgccg agtgaagtgt ggcccccggc 1740 tgtcagcaga ggctgcagag aaactgaaga accgctacat catcatgcgg agcggggccc 1800 gtcagcacga gagggacagt gaccgccgct ccagcatccc catcactgtg cggcagctgg 1860 aggccattgt gcgcatcgcg gaagccctca gcaagatgaa gctgcagccc ttcgccacag 1920 aggcagatgt ggaggaggcc ctgcggctct tccaagtgtc cacgttggat gctgccttgt 1980 ccggtaccct gtcaggggtg gagggcttca ccagccagga ggaccaggag atgctgagcc 2040 gcatcgagaa gcagctcaag cgccgctttg ccattggctc ccaggtgtct gagcacagca 2100 tcatcaagga cttcaccaag cagaaatacc cggagcacgc catccacaag gtgctgcagc 2160 tcatgctgcg gcgcggcgag atccagcatc gcatgcagcg caaggttctc taccgcctca 2220 agtgagtcgc gccgcctcac tggactcatg gactcgccca cgcctcgccc ctcctgccgc 2280 tgcctgccat tgacaatgtt gctgggacct ctgcctcccc actgcagccc tcgaacttcc 2340 caggcaccct cctttctgcc ccagaggaag gagctgtagt gtcctgctgc ctctgggcgc 2400 ccgcctctag cgcggttctg ggaagtgtgc ttttggcatc cgttaataat aaagccacgg 2460 tgtgttcagg taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2520 aaaaaaaaaa aaaa 2534 <210> 59 <211> 2512 <212> DNA <213> Homo sapiens <400> 59 cttgtctccc ctggtttgtg aagtgcggaa aaccagaggc gcagtcatgt cgggattcga 60 cgatcctggc attttctaca gcgacagctt cgggggcgac gcccaggccg acgaggggca 120 ggcccgcaaa tcgcagctgc agaggcgctt caaggagttc ctgcggcagt accgagtggg 180 caccgaccgc acgggcttca ccttcaaata cagggatgaa ctcaagcggc attacaacct 240 gggggagtac tggattgagg tggagatgga ggatctggcc agctttgatg aggacctggc 300 cgactacttg tacaagcagc cagccgagca cctgcagctg ctggaggaag ctgccaagga 360 ggtagctgat gaggtgaccc ggccccggcc ttctggggag gaggtgctcc aggacatcca 420 ggtcatgctc aagtcggacg ccagcccttc cagcattcgt agcctgaagt cggacatgat 480 gtcacacctg gtgaagatcc ctggcatcat catcgcggcc tctgcggtcc gtgccaaggc 540 cacccgcatc tctatccagt gccgcagctg ccgcaacacc ctcaccaaca ttgccatgcg 600 ccctggcctc gagggctatg ccctgcccag gaagtgcaac acagatcagg ctgggcgccc 660 caaatgccca ttggacccgt acttcatcat gcccgacaaa tgcaaatgcg tggacttcca 720 gaccctgaag ctgcaggagc tgcctgatgc agtcccccac ggggagatgc ccagacacat 780 gcagctctac tgcgacaggt acctgtgtga caaggtcgtc cctgggaaca gggttaccat 840 catgggcatc tactccatca agaagtttgg cctgaccacc agcaggggcc gtgacagggt 900 gggcgtgggc atccgaagct cctacatccg tgtcctgggc atccaggtgg acacagatgg 960 ctctggccgc agctttgctg gggccgtgag cccccaggag gaggaggagt tccgtcgcct 1020 ggctgccctc ccaaatgtct atgaggtcat ctccaagagc atcgccccct ccatctttgg 1080 gggcacagac atgaagaagg ccattgcctg cctgctcttt gggggctccc gaaagaggct 1140 ccctgatgga cttactcgcc gaggagacat caacctgctg atgctagggg accctgggac 1200 agccaagtcc cagcttctga agtttgtgga gaagtgttct cccattgggg tatacacgtc 1260 tgggaaaggc agcagcgcag ctggactgac agcctcggtg atgagggacc cttcgtcccg 1320 gaatttcatc atggagggcg gagccatggt cctggccgat ggtggggtcg tctgtattga 1380 cgagtttgac aagatgcgag aagatgaccg tgtggcaatc cacgaagcca tggagcagca 1440 gaccatctct atcgccaagg ctgggatcac caccaccctg aactcccgct gctccgtcct 1500 ggctgctgcc aactcagtgt tcggccgctg ggatgagacg aagggggagg acaacattga 1560 cttcatgccc accatcttgt cgcgcttcga catgatcttc atcgtcaagg atgagcacaa 1620 tgaggagagg gatgtgatgc tggccaagca tgtcatcact ctgcacgtga gcgcactgac 1680 acagacacag gctgtggagg gcgagattga cctggccaag ctgaagaagt ttattgccta 1740 ctgccgagtg aaatgtggcc cccggctgtc agcagaggct gcagagaaac tgaagaaccg 1800 ctacatcatc atgcggagcg gggcccgtca gcacgagagg gacagtgacc gccgctccag 1860 catccccatc actgtgcggc agctggaggc cattgtgcgc atcgcggaag ccctcagcaa 1920 gatgaagctg cagcccttcg ccacagaggc agatgtggag gaggccctgc ggctcttcca 1980 agtgtccacg ttggatgctg ccttgtccgg taccctgtca ggggtggagg gcttcaccag 2040 ccaggaggac caggagatgc tgagccgcat cgagaagcag ctcaagcgcc gctttgccat 2100 tggctcccag gtgtctgagc acagcatcat caaggacttc accaagcaga aatacccgga 2160 gcacgccatc cacaaggtgc tgcagctcat gctgcggcgc ggcgagatcc agcatcgcat 2220 gcagcgcaag gttctctacc gcctcaagtg agtcgcgccg cctcactgga ctcatggact 2280 cgcccacgcc tcgcccctcc tgccgctgcc tgccattgac aatgttgctg ggacctctgc 2340 ctccccactg cagccctcga acttcccagg caccctcctt tctgccccag aggaaggagc 2400 tgtagtgtcc tgctgcctct gggcgcccgc ctctagcgcg gttctgggaa gtgtgctttt 2460 ggcatccgtt aataataaag ccacggtgtg ttcaggtaaa aaaaaaaaaa aa 2512 <210> 60 <211> 2525 <212> DNA <213> Homo sapiens <400> 60 ttttcccgcg aaactcggcg gctgagcgtg gaggttcttg tctcccctgg tttgtgaagt 60 gcggaaaacc agaggcgcag tcatgtcggg attcgacgat cctggcattt tctacagcga 120 cagcttcggg ggcgacgccc aggccgacga ggggcaggcc cgcaaatcgc agctgcagag 180 gcgcttcaag gagttcctgc ggcagtaccg agtgggcacc gaccgcacgg gcttcacctt 240 caaatacagg gatgaactca agcggcatta caacctgggg gagtactgga ttgaggtgga 300 gatggaggat ctggccagct ttgatgagga cctggccgac tacttgtaca agcagccagc 360 cgagcacctg cagctgctgg aggaagctgc caaggaggta gctgatgagg tgacccggcc 420 ccggccttct ggggaggagg tgctccagga catccaggtc atgctcaagt cggacgccag 480 cccttccagc attcgtagcc tgaagtcgga catgatgtca cacctggtga agatccctgg 540 catcatcatc gcggcctctg cggtccgtgc caaggccacc cgcatctcta tccagtgccg 600 cagctgccgc aacaccctca ccaacattgc catgcgccct ggcctcgagg gctatgccct 660 gcccaggaag tgcaacacag atcaggctgg acgccccaaa tgcccattgg acccgtactt 720 catcatgccc gacaaatgca aatgcgtgga cttccagacc ctgaagctgc aggagctgcc 780 tgatgcagtc ccccacgggg agatgcccag acacatgcag ctctactgcg acaggtacct 840 gtgtgacaag gtcgtccctg ggaacagggt taccatcatg ggcatctact ccatcaagaa 900 gtttggcctg actaccagca ggggccgtga cagggtgggc gtgggcatcc gaagctccta 960 catccgtgtc ctgggcatcc aggtggacac agatggctct ggccgcagct ttgctggggc 1020 cgtgagcccc caggaggagg aggagttccg tcgcctggct gccctcccaa atgtctatga 1080 ggtcatctcc aagagcatcg ccccctccat ctttgggggc acagacatga agaaggccat 1140 tgcctgcctg ctctttgggg gctcccgaaa gaggctccct gatggactta ctcgccgagg 1200 agacatcaac ctgctgatgc taggggaccc tgggacagcc aagtcccagc ttctgaagtt 1260 tgtggagaag tgttctccca ttggggtata cacgtctggg aaaggcagca gcgcagctgg 1320 actgacagcc tcggtgatga gggacccttc gtcccggaat ttcatcatgg agggcggagc 1380 catggtcctg gccgatggtg gggtcgtctg tattgacgag tttgacaaga tgcgagaaga 1440 tgaccgtgtg gcaatccacg aagccatgga gcagcagacc atctctatcg ccaaggctgg 1500 gatcaccacc accctgaact cccgctgctc cgtcctggct gctgccaact cagtgttcgg 1560 ccgctgggat gagacgaagg gggaggacaa cattgacttc atgcccacca tcttgtcgcg 1620 cttcgacatg atcttcatcg tcaaggatga gcacaatgag gtgagggatg tgatgctggc 1680 caagcatgtc atcactctgc acgtgagtgc actgacacag acacaggctg tggagggcga 1740 gattgacctg gccaagctga agaagtttat tgcctactgc cgagtgaagt gtggcccccg 1800 gctgtcagca gaggctgcag agaaactgaa gaaccgctac atcatcatgc ggacggggcc 1860 cgtcagcacg agagggacag tgaccgcgtc cagcatcccc atcactgtgc ggcagttgga 1920 ggccattgtg cgcatcgcgg aagccctcag caagatgaag ctgcagccct tcgccacaga 1980 ggcagatgtg gaggaggccc tgcggctctt ccaagtgtcc acgttggatg ctgccttgtc 2040 cggtaccctg tcaggggtgg agggcttcac cagccaggag gaccaggaga tgctgagccg 2100 catcgagaag cagctcaagc gccgctttgc cattggctcc caggtgtctg agcacagcat 2160 catcaaggac ttcaccaagc agaaataccc ggagcacgcc atccacaagg tgctgcagct 2220 catgctgcgg cgcggcgaga tccagcatcg catgcagcgc aaggttctct accgcctcaa 2280 gtgagtcgcg ccgctcactg gactcatgga ctcgccacgc tcgccctcct tgccgctgcc 2340 tgccattgac aatgttgctg ggacctctgc ctccccactg cagccctcga acttcccagg 2400 caccctcctt tctgccccag aggaaggagc tgtagtgtcc tgctgcctct gggcgcccgc 2460 tctagcgggt tctgggaagt gtgcttttgg catccgttaa taataaagcc acggtgtgtt 2520 caggt 2525 <210> 61 <211> 2499 <212> DNA <213> Homo sapiens <400> 61 gcgaaactcg gcggctgagc gtggaggttc ttgtctcccc tggtttgtga agtgcggaaa 60 accagaggcg cagtcatgtc gggattcgac gatcctggca ttttctacag cgacagcttc 120 gggggcgacg cccaggccga cgaggggcag gcccgcaaat cgcagctgca gaggcgcttc 180 aaggagttcc tgcggcagta ccgagtgggc accgaccgca cgggcttcac cttcaaatac 240 agggatgaac tcaagcggca ttacaacctg gaggatctgg ccagctttga tgaggacctg 300 gccgactact tgtacaagca gccagccgag cacctgcagc tgctggagga agctgccaag 360 gaggtagctg atgaggtgac ccggccccgg ccttctgggg aggaggtgct ccaggacatc 420 caggtcatgc tcaagtcgga cgccagccct tccagcattc gtagcctgaa gtcggacatg 480 atgtcacacc tggtgaagat ccctggcatc atcatcgcgg cctctgcggt ccgtgccaag 540 gccacccgca tctctatcca gtgccgcagc tgccgcaaca ccctcaccaa cattgccatg 600 cgccctggcc tcgagggcta tgccctgccc aggaagtgca acacagatca ggctgggcgc 660 cccaaatgcc cattggaccc gtacttcatc atgcccgaca aatgcaaatg cgtggacttc 720 cagaccctga agctgcagga gctgcctgat gcagtccccc acggggagat gcccagacac 780 atgcagctct actgcgacag gtacctgtgt gacaaggtcg tccctgggaa cagggttacc 840 atcatgggca tctactccat caagaagttt ggcctgacta ccagcagggg ccgtgacagg 900 gtgggcgtgg gcatccgaag ctcctacatc cgtgtcctgg gcatccaggt ggacacagat 960 ggctctggcc gcagctttgc tggggccgtg agcccccagg aggaggagga gttccgtcgc 1020 ctggctgccc tcccaaatgt ctatgaggtc atctccaaga gcatcgcccc ctccatcttt 1080 gggggcacag acatgaagaa ggccattgcc tgcctgctct ttgggggctc ccgaaagagg 1140 ctccctgatg gacttactcg ccgaggagac atcaacctgc tgatgctagg ggaccctggg 1200 acagccaagt cccagcttct gaagtttgtg gagaagtgtt ctcccattgg ggtatacacg 1260 tctgggaaag gcagcagcgc agctggactg acagcctcgg tgatgaggga cccttcgtcc 1320 cggaatttca tcatggaggg cggagccatg gtcctggccg atggtggggt cgtctgtatt 1380 gacgagtttg acaagatgcg agaagatgac cgtgtggcaa tccacgaagc catggagcag 1440 cagaccatct ctatcgccaa ggctgggatc accaccaccc tgaactcccg ctgctccgtc 1500 ctggctgctg ccaactcagt gttcggccgc tgggatgaga cgaaggggga ggacaacatt 1560 gacttcatgc ccaccatctt gtcgcgcttc gacatgatct tcatcgtcaa ggatgagcac 1620 aatgaggaga gggatgtgat gctggccaag catgtcatca ctctgcacgt gagcgcactg 1680 acacagacac aggctgtgga gggcgagatt gacctggcca agctgaagaa gtttattgcc 1740 tactgccgag tgaagtgtgg cccccggctg tcagcagagg ctgcagagaa actgaagaac 1800 cgctacatca tcatgcggag cggggcccgt cagcacgaga gggacagtga ccgccgctcc 1860 agcatcccca tcactgtgcg gcagctggag gccattgtgc gcatcgcgga agccctcagc 1920 aagatgaagc tgcagccctt cgccacagag gcagatgtgg aggaggccct gcggctcttc 1980 caagtgtcca cgttggatgc tgccttgtcc ggtaccctgt caggggtgga gggcttcacc 2040 agccaggagg accaggagat gctgagccgc atcgagaagc agctcaagcg ccgctttgcc 2100 attggctccc aggtgtctga gcacagcatc atcaaggact tcaccaagca gaaatacccg 2160 gagcacgcca tccacaaggt gctgcagctc atgctgcggc gcggcgagat ccagcatcgc 2220 atgcagcgca aggttctcta ccgcctcaag tgagtcgcgc cgcctcactg gactcatgga 2280 ctcgcccacg cctcgcccct cctgccgctg cctgccattg acaatgttgc tgggacctct 2340 gcctccccac tgcagccctc gaacttccca ggcaccctcc tttctgcccc agaggaagga 2400 gctgtagtgt cctgctgcct ctgggcgccc gcctctagcg cggttctggg aagtgtgctt 2460 ttggcatccg ttaataataa agccacggtg tgttcaggt 2499 <210> 62 <211> 2393 <212> DNA <213> Homo sapiens <400> 62 aactcggcgg ctgagcgtgg aggttcttgt ctcccctggt ttgtgaagtg cggaaaacca 60 gaggcgcagt catgtcggga ttcgacgatc ctggcatttt ctacagcgac agcttcgggg 120 gcgacgccca ggccgacgag gggcaggccc gcaaatcgca gctgcagagg cgcttcaagg 180 agttcctgcg gcagtaccga gtgggcaccg accgcacggg cttcaccttc aaatacaggg 240 atgaactcaa gcggcattac aacctggggg agtactggat tgaggtggag atggaggatc 300 tggccagctt tgatgaggac ctggccgact acttgtacaa gcagccagcc gagcacctgc 360 agctgtcgga catgatgtca cacctggtga agatccctgg catcatcatc gcggcctctg 420 cggtccgtgc caaggccacc cgcatctcta tccagtgccg cagctgccgc aacaccctca 480 ccaacattgc tatgcgccct ggcctcgagg gctatgccct gcccaggaag tgcaacacag 540 atcaggctgg gcgccccaaa tgcccattgg acccgtactt catcatgccc gacaaatgca 600 aatgcgtgga cttccagacc ctgaagctgc aggagctgcc tgatgcagtc ccccacgggg 660 agatgcccag acacatgcag ctctactgcg acaggtacct gtgtgacaag gtcgtccctg 720 ggaacagggt taccatcatg ggcatctact ccatcaagaa gtttggcctg actaccagca 780 ggggccgtga cagggtgggc gtgggcatcc gaagctccta catccgtgtc ctgggcatcc 840 aggtggacac agatggctct ggccgcagct ttgctggggc cgtgagcccc caggaggagg 900 atgagttccg tcgcctggct gccctcccaa atgtctatga ggtcatctcc aagagcatcg 960 ccccctccat ctttgggggc acagacatga agaaggccat tgcctgcctg ctctttgggg 1020 gctcccgaaa gaggctccct gatggactta ctcgccgagg agacatcaac ctgctgatgc 1080 taggggaccc tgggacagcc aagtcccagc ttctgaagtt tgtggagaag tgttctccca 1140 ttggggtata cacgtctggg aaaggcagca gcgcagctgg actgacagcc tcggtgatga 1200 gggacccttc gtcccggaat ttcatcatgg agggcggagc catggtcctg gccgatggtg 1260 gggtcgtctg tattgacgag tttgacaaga tgcgagaaga tgaccgtgtg gcaatccacg 1320 aagccatgga gcagcagacc atctctatcg ccaaggctgg gatcaccacc accctgaact 1380 cccgctgctc cgtcctggct gctgccaact cagtgttcgg ccgctgggat gagacgaagg 1440 gggaggacaa cattgacttc atgcccacca tcttgtcgcg cttcgacatg atcttcatcg 1500 tcaaggatga gcacaatgag gagagggatg tgatgctggc caagcatgtc atcactctgc 1560 acgtgagcgc actgacacag acacaggctg tggagggcga gattgacctg gccaagctga 1620 agaagtttat tgcctactgc cgagtgaagt gtggcccccg gctgtcagca gaggctgcag 1680 agaaactgaa gaaccgctac atcatcatgc ggagcggggc ccgtcagcac gagagggaca 1740 gtgaccgccg ctccagcatc cccatcactg tgcggcagct ggaggccatt gtgcgcatcg 1800 cggaagccct cagcaagatg aagctgcagc cctccgccac agaggcagat gtggaggagg 1860 ccctgcggct cttccaagtg tccacgttgg atgctgcctt gtccggtacc ctgtcagggg 1920 tggagggctt caccagccag gaggaccagg agatgctgag ccgcatcgag aagcagctca 1980 agcgccgctt tgccattggc tcccaggtgt ctgagcacag catcatcaag gacttcacca 2040 agcagaaata cccggagcac gccatccaca aggtgctgca gctcatgctg cggcgcggcg 2100 agatccagca tcgcatgcag cgcaaggttc tctaccgcct caagtgagtc gcgccgcccc 2160 actggactca tggactcgcc cacgcctcgc ccctcctgcc gctgcctgcc attgacaatg 2220 ttgctgggac ctctgcctcc ccactgcagc cctcgaactt cccaggcacc ctcctttctg 2280 ccccagagga aggagctgta gtgtcctgct gcctctgggc gcccgcctct agcgcggttc 2340 tgggaagtgt gcttttggca tccgttaata ataaagccac ggtgtgttca ggt 2393 <210> 63 <211> 2412 <212> DNA <213> Homo sapiens <400> 63 gtccaccgcg cggagattct cagcttcccc aggagcaaga cctctgagcc cgccaagcgc 60 ggccgcacgg ccctcggcag cgatggcact gaaggactac gcgctagaga aggaaaaggt 120 taagaagttc ttacaagagt tctaccagga tgatgaactc gggaagaagc agttcaagta 180 tgggaaccag ttggttcggc tggctcatcg ggaacaggtg gctctgtatg tggacctgga 240 cgacgtagcc gaggatgacc ccgagttggt ggactcaatt tgtgagaatg ccaggcgcta 300 cgcgaagctc tttgctgatg ccgtacaaga gctgctgcct cagtacaagg agagggaagt 360 ggtaaataaa gatgtcctgg acgtttacat tgagcatcgg ctaatgatgg agcagcggag 420 tcgggaccct gggatggtcc gaagccccca gaaccagtac cctgctgaac tcatgcgcag 480 atttgagctg tattttcaag gccctagcag caacaagcct cgtgtgatcc gggaagtgcg 540 ggctgactct gtggggaagt tggtaactgt gcgtggaatc gtcactcgtg tctctgaagt 600 caaacccaag atggtggtgg ccacttacac ttgtgaccag tgtggggcag agacctacca 660 gccgatccag tctcccactt tcatgcctct gatcatgtgc ccaagccagg agtgccaaac 720 caaccgctca ggagggcggc tgtatctgca gacacggggc tccagattca tcaaattcca 780 ggagatgaag atgcaagaac atagtgatca ggtgcctgtg ggaaatatcc ctcgtagtat 840 cacggtgctg gtagaaggag agaacacaag gattgcccag cctggagacc acgtcagcgt 900 cactggtatt ttcttgccaa tcctgcgcac tgggttccga caggtggtac agggtttact 960 ctcagaaacc tacctggaag cccatcggat tgtgaagatg aacaagagtg aggatgatga 1020 gtctggggct ggagagctca ccagggagga gctgaggcaa attgcagagg aggatttcta 1080 cgaaaagctg gcagcttcaa tcgccccaga aatatacggg catgaagatg tgaagaaggc 1140 actgctgctc ctgctagtcg ggggtgtgga ccagtctcct cgaggcatga aaatccgggg 1200 caacatcaac atctgtctga tgggggatcc tggtgtggcc aagtctcagc tcctgtcata 1260 cattgatcga ctggcgcctc gcagccagta cacaacaggc cggggctcct caggagtggg 1320 gcttacggca gctgtgctga gagactccgt gagtggagaa ctgaccttag agggtggggc 1380 cctggtgctg gctgaccagg gtgtgtgctg cattgatgag ttcgacaaga tggctgaggc 1440 cgaccgcaca gccatccacg aggtcatgga gcagcagacc atctccattg ccaaggccgg 1500 cattctcacc acactcaatg cccgctgctc catcctggct gccgccaacc ctgcctacgg 1560 gcgctacaac cctcgccgca gcctggagca gaacatacag ctacctgctg cactgctctc 1620 ccggtttgac ctcctctggc tgattcagga ccggcccgac cgagacaatg acctacggtt 1680 ggcccagcac attacctatg tgcaccagca cagccggcag cccccctccc agtttgaacc 1740 tctggacatg aagctcatga ggcgttacat agccatgtgc cgcgagaagc agcccatggt 1800 gccagagtct ctggctgact acatcacagc agcatacgtg gagatgaggc gagaggcttg 1860 ggctagtaag gatgccacct atacttctgc ccggaccctg ctggctatcc tgcgcctttc 1920 cactgctctg gcacgtctga gaatggtgga tgtggtggag aaagaagatg tgaatgaagc 1980 catcaggcta atggagatgt caaaggactc tcttctagga gacaaggggc agacagctag 2040 gactcagaga ccagcagatg tgatatttgc caccgtccgt gaactggtct cagggggccg 2100 aagtgtccgg ttctctgagg cagagcagcg ctgtgtatct cgtggcttca cacccgccca 2160 gttccaggcg gctctggatg aatatgagga gctcaatgtc tggcaggtca atgcttcccg 2220 gacacggatc acttttgtct gattccagcc tgcttgcaac cctggggtcc tcttgttccc 2280 tgctggcctg ccccttggga aggggcagtg atgcctttga ggggaaggag gagcccctct 2340 ttctcccatg ctgcacttac tccttttgct aataaaagtg tttgtagatt gtcaaaaaaa 2400 aaaaaaaaaa aa 2412 <210> 64 <211> 2900 <212> DNA <213> Homo sapiens <400> 64 agtgtcgtgt aaacagtgtc cttccgcgcg gcggccgcgg agagagctgc ggcccggggg 60 ggcgtgcctg ggatccggag cttcgctcgg gcccgggaaa ggcggcagtg ggctgggatc 120 gcggtgtctc tgggtgtgat ggccaatggc tggactggct cccgccctgg gcggaggaat 180 cccgagctgt gaagcggctg gaatccgggc ccatgtgctt ctttgtttac taagagcgga 240 agcgatggcg ggagcggggg tggggtgcgg tggcggggtg cggtggcgga ggtcccggtg 300 aaatcagggg ctaaggggac ccaaagaagg cgggggatca taggggtgga aagaaagctg 360 agaaccttga gaccggagtg tgaggggcca acggggaagg gcgctagaat tttaaactaa 420 agtagggacc ggaattcccc tggggagatg ttggatggcc ctgtgcactg ccacgggctc 480 tttattcttc gctggttaga aacagacttg tgaaaaagag ttatgcccac tttggggaga 540 cttcgaaaag gttaagaagt tcttacaaga gttctaccag gatgatgaac tcgggaagaa 600 gcagttcaag tatgggaacc agttggttcg gctggctcat cgggaacagg tggctctgta 660 tgtggacctg gacgacgtag ccgaggatga ccccgagttg gtggactcaa tttgtgagaa 720 tgccaggcgc tacgcgaagc tctttgctga tgccgtacaa gagctgctgc ctcagtacaa 780 ggagagggaa gtggtaaata aagatgtcct ggacgtttac attgagcatc ggctaatgat 840 ggagcagcgg agtcgggacc ctgggatggt ccgaagcccc cagaaccagt accctgctga 900 actcatgcgc agattgtgag tggtctctgt cgggaaagat gtagggattg gttctccagg 960 atcttgtttg tgactgtttt ctccccttag tgagctgtat tttcaaggcc ctagcagcaa 1020 caagcctcgt gtgatccggg aagtgcgggc tgactctgtg gggaagttgg taactgtgcg 1080 tggaatcgtc actcgtgtct ctgaagtcaa acccaagatg gtggtggcca cttacacttg 1140 tgaccagtgt ggggcagaga cctaccagcc gatccagtct cccactttca tgcctctgat 1200 catgtgccca agccaggagt gccaaaccaa ccgctcagga gggcggctgt atctgcagac 1260 acggggctcc agattcatca aattccagga gatgaagatg caagaacata gtgatcaggt 1320 gcctgtggga aatatccctc gtagtatcac ggtgctggta gaaggagaga acacaaggat 1380 tgcccagcct ggagaccacg tcagcgtcac tggtattttc ttgccaatcc tgcgcactgg 1440 gttccgacag gtggtacagg gtttactctc agaaacctac ctggaagccc atcggattgt 1500 gaagatgaac aagagtgagg atgatgagtc tggggctgga gagctcacca gggaggagct 1560 gaggcaaatt gcagaggagg atttctacga aaagctggca gcttcaatcg ccccagaaat 1620 atacgggcat gaagatgtga agaaggcact gctgctcctg ctagtcgggg gtgtggacca 1680 gtctcctcga ggcatgaaaa tccggggcaa catcaacatc tgtctgatgg gggatcctgg 1740 tgtggccaag tctcagctcc tgtcatacat tgatcgactg gcgcctcgca gccagtacac 1800 aacaggccgg ggctcctcag gagtggggct tacggcagct gtgctgagag actccgtgag 1860 tggagaactg accttagagg gtggggccct ggtgctggct gaccagggtg tgtgctgcat 1920 tgatgagttc gacaagatgg ctgaggccga ccgcacagcc atccacgagg tcatggagca 1980 gcagaccatc tccattgcca aggccggcat tctcaccaca ctcaatgccc gctgctccat 2040 cctggctgcc gccaaccctg cctacgggcg ctacaaccct cgccgcagcc tggagcagaa 2100 catacagcta cctgctgcac tgctctcccg gtttgacctc ctctggctga ttcaggaccg 2160 gcccgaccga gacaatgacc tacggttggc ccagcacatc acctatgtgc accagcacag 2220 ccggcagccc ccctcccagt ttgaacctct ggacatgaag ctcatgaggc gttacatagc 2280 catgtgccgc gagaagcagc ccatggtgcc agagtctctg gctgactaca tcacagcagc 2340 atacgtggag atgaggcgag aggcttgggc tagtaaggat gccacctata cttctgcccg 2400 gaccctgctg gctatcctgc gcctttccac tgctctggca cgtctgagaa tggtggatgt 2460 ggtggagaaa gaagatgtga atgaagccat caggctaatg gagatgtcaa aggactctct 2520 tctaggagac aaggggcaga cagctaggac tcagagacca gcagatgtga tatttgccac 2580 cgtccgtgaa ctggtctcag ggggccgaag tgtccggttc tctgaggcag agcagcgctg 2640 tgtatctcgt ggcttcacac ccgcccagtt ccaggcggct ctggatgaat atgaggagct 2700 caatgtctgg caggtcaatg cttcccggac acggatcact tttgtctgat tccagcctgc 2760 ttgcaaccct ggggtcctct tgttccctgc tggcctgccc cttgggaagg ggcagtgatg 2820 cctttgaggg gaaggaggag cccctctttc tcccatgctg cacttactcc ttttgctaat 2880 aaaagtgttt gtagattgtc 2900 <210> 65 <211> 2821 <212> DNA <213> Homo sapiens <400> 65 cgccccttcc cagccccaag ggtctaggat acagtctttg tagatgagcg ggtccccctt 60 ggaggacaga atgaagaatt gggaaatcat ggccgttctg gagagtagac aagaagacgg 120 cgaaagtcgg gcctgccccg ccctgcggcc ccggaacaaa agaacgcgtg tgcgctggcc 180 ctttaagagc gattctcctc cgcccgcgcc agctcggacc gcgggaaacc cggcgcctgc 240 actaccccgc ccggagattc ccttccgacg cccgcaccgc ctccccgtca ctcattctag 300 gcccgcacgg tgattggctt gcggctagcg ggaggtgaag aaggccgcct tgtccgattg 360 gcccgcacgc agtggcgccg gtcacgtggg gggcgacgtt tcgcgccaat ttcggttggc 420 cggccacagt ccaccgcgcg gagattctca gcttccccag gagcaagacc tctgagcccg 480 ccaagcgcgg ccgcacggcc ctcggcagcg atggcactga aggactacgc gctagagaag 540 gaaaaggtta agaagttctt acaagagttc taccaggatg atgaactcgg gaagaagcag 600 ttcaagtatg ggaaccagtt ggttcggctg gctcatcggg aacaggtggc tctgtatgtg 660 gacctggacg acgtagccga ggatgacccc gagttggtgg actcaatttg tgagaatgcc 720 aggcgctacg cgaagctctt tgctgatgcc gtacaagagc tgctgcctca gtacaaggag 780 agggaagtgg taaataaaga tgtcctggac gtttacattg agcatcggct aatgatggag 840 cagcggagtc gggaccctgg gatggtccga agcccccaga accagtaccc tgctgaactc 900 atgcgcagat ttgagctgta ttttcaaggc cctagcagca acaagcctcg tgtgatccgg 960 gaagtgcggg ctgactctgt ggggaagttg gtaactgtgc gtggaatcgt cactcgtgtc 1020 tctgaagtca aacccaagat ggtggtggcc acttacactt gtgaccagtg tggggcagag 1080 acctaccagc cgatccagtc tcccactttc atgcctctga tcatgtgccc aagccaggag 1140 tgccaaacca accgctcagg agggcggctg tatctgcaga cacggggctc cagattcatc 1200 aaattccagg agatgaagat gcaagaacat agtgatcagg tgcctgtggg aaatatccct 1260 cgtagtatca cggtgctggt agaaggagag aacacaagga ttgcccagcc tggagaccac 1320 gtcagcgtca ctggtatttt cttgccaatc ctgcgcactg ggttccgaca ggtggtacag 1380 ggtttactct cagaaaccta cctggaagcc catcggattg tgaagatgaa caagagtgag 1440 gatgatgagt ctggggctgg agagctcacc agggaggagc tgaggcaaat tgcagaggag 1500 gatttctacg aaaagctggc agcttcaatc gccccagaaa tatacgggca tgaagatgtg 1560 aagaaggcac tgctgctcct gctagtcggg ggtgtggacc agtctcctcg aggcatgaaa 1620 atccggggca acatcaacat ctgtctgatg ggggatcctg gtgtggccaa gtctcagctc 1680 ctgtcataca ttgatcgact ggcgcctcgc agccagtaca caacaggccg gggctcctca 1740 ggagtggggc ttacggcagc tgtgctgaga gactccgtga gtggagaact gaccttagag 1800 ggtggggccc tggtgctggc tgaccagggt gtgtgctgca ttgatgagtt cgacaagatg 1860 gctgaggccg accgcacagc catccacgag gtcatggagc agcagaccat ctccattgcc 1920 aaggccggca ttctcaccac actcaatgcc cgctgctcca tcctggctgc cgccaaccct 1980 gcctacgggc gctacaaccc tcgccgcagc ctggagcaga acatacagct acctgctgca 2040 ctgctctccc ggtttgacct cctctggctg attcaggacc ggcccgaccg agacaatgac 2100 ctacggttgg cccagcacat cacctatgtg caccagcaca gccggcagcc cccctcccag 2160 tttgaacctc tggacatgaa gctcatgagg cgttacatag ccatgtgccg cgagaagcag 2220 cccatggtgc cagagtctct ggctgactac atcacagcag catacgtgga gatgaggcga 2280 gaggcttggg ctagtaagga tgccacctat acttctgccc ggaccctgct ggctatcctg 2340 cgcctttcca ctgctctggc acgtctgaga atggtggatg tggtggagaa agaagatgtg 2400 aatgaagcca tcaggctaat ggagatgtca aaggactctc ttctaggaga caaggggcag 2460 acagctagga ctcagagacc agcagatgtg atatttgcca ccgtccgtga actggtctca 2520 gggggccgaa gtgtccggtt ctctgaggca gagcagcgct gtgtatctcg tggcttcaca 2580 cccgcccagt tccaggcggc tctggatgaa tatgaggagc tcaatgtctg gcaggtcaat 2640 gcttcccgga cacggatcac ttttgtctga ttccagcctg cttgcaaccc tggggtcctc 2700 ttgttccctg ctggcctgcc ccttgggaag gggcagtgat gcctttgagg ggaaggagga 2760 gcccctcttt ctcccatgct gcacttactc cttttgctaa taaaagtgtt tgtagattgt 2820 c 2821 <210> 66 <211> 2327 <212> DNA <213> Homo sapiens <400> 66 cgcaaacatt atgggacccc tttaaatcaa agataagaat ctggcattcc tgggctgcat 60 atagcccata gatctgtttg atttggctaa ttcggttttt aggattgaat ttattgacaa 120 ttctgaacat tcgggccatt tcccataaag ctcactattt ccaatttccc ttgagaaaat 180 ggaaagctcc cacataggtg ggtgtgttca cttggggctc agtagtggtg gccctgtttt 240 caagagggca gtcctcacca tgtcacccca tccccaccta gcctgcttct ctcaattatt 300 ttacctgcct ggtccctata ggcatttgtg tcagcccctt ttgctttaag tctctgtcgg 360 gaaagatgta gggattggtt ctccaggatc ttgtttgtga ctgttttctc cccttagtga 420 gctgtatttt caaggcccta gcagcaacaa gcctcgtgtg atccgggaag tgcgggctga 480 ctctgtgggg aagttggtaa ctgtgcgtgg aatcgtcact cgtgtctctg aagtcaaacc 540 caagatggtg gtggccactt acacttgtga ccagtgtggg gcagagacct accagccgat 600 ccagtctccc actttcatgc ctctgatcat gtgcccaagc caggagtgcc aaaccaaccg 660 ctcaggaggg cggctgtatc tgcagacacg gggctccaga ttcatcaaat tccaggagat 720 gaagatgcaa gaacatagtg atcaggtgcc tgtgggaaat atccctcgta gtatcacggt 780 gctggtagaa ggagagaaca caaggattgc ccagcctgga gaccacgtca gcgtcactgg 840 tattttcttg ccaatcctgc gcactgggtt ccgacaggtg gtacagggtt tactctcaga 900 aacctacctg gaagcccatc ggattgtgaa gatgaacaag agtgaggatg atgagtctgg 960 ggctggagag ctcaccaggg aggagctgag gcaaattgca gaggaggatt tctacgaaaa 1020 gctggcagct tcaatcgccc cagaaatata cgggcatgaa gatgtgaaga aggcactgct 1080 gctcctgcta gtcgggggtg tggaccagtc tcctcgaggc atgaaaatcc ggggcaacat 1140 caacatctgt ctgatggggg atcctggtgt ggccaagtct cagctcctgt catacattga 1200 tcgactggcg cctcgcagcc agtacacaac aggccggggc tcctcaggag tggggcttac 1260 ggcagctgtg ctgagagact ccgtgagtgg agaactgacc ttagagggtg gggccctggt 1320 gctggctgac cagggtgtgt gctgcattga tgagttcgac aagatggctg aggccgaccg 1380 cacagccatc cacgaggtca tggagcagca gaccatctcc attgccaagg ccggcattct 1440 caccacactc aatgcccgct gctccatcct ggctgccgcc aaccctgcct acgggcgcta 1500 caaccctcgc cgcagcctgg agcagaacat acagctacct gctgcactgc tctcccggtt 1560 tgacctcctc tggctgattc aggaccggcc cgaccgagac aatgacctac ggttggccca 1620 gcacatcacc tatgtgcacc agcacagccg gcagcccccc tcccagtttg aacctctgga 1680 catgaagctc atgaggcgtt acatagccat gtgccgcgag aagcagccca tggtgccaga 1740 gtctctggct gactacatca cagcagcata cgtggagatg aggcgagagg cttgggctag 1800 taaggatgcc acctatactt ctgcccggac cctgctggct atcctgcgcc tttccactgc 1860 tctggcacgt ctgagaatgg tggatgtggt ggagaaagaa gatgtgaatg aagccatcag 1920 gctaatggag atgtcaaagg actctcttct aggagacaag gggcagacag ctaggactca 1980 gagaccagca gatgtgatat ttgccaccgt ccgtgaactg gtctcagggg gccgaagtgt 2040 ccggttctct gaggcagagc agcgctgtgt atctcgtggc ttcacacccg cccagttcca 2100 ggcggctctg gatgaatatg aggagctcaa tgtctggcag gtcaatgctt cccggacacg 2160 gatcactttt gtctgattcc agcctgcttg caaccctggg gtcctcttgt tccctgctgg 2220 cctgcccctt gggaaggggc agtgatgcct ttgaggggaa ggaggagccc ctctttctcc 2280 catgctgcac ttactccttt tgctaataaa agtgtttgta gattgtc 2327 <210> 67 <211> 2900 <212> DNA <213> Homo sapiens <400> 67 agtgtcgtgt aaacagtgtc cttccgcgcg gcggccgcgg agagagctgc ggcccggggg 60 ggcgtgcctg ggatccggag cttcgctcgg gcccgggaaa ggcggcagtg ggctgggatc 120 gcggtgtctc tgggtgtgat ggccaatggc tggactggct cccgccctgg gcggaggaat 180 cccgagctgt gaagcggctg gaatccgggc ccatgtgctt ctttgtttac taagagcgga 240 agcgatggcg ggagcggggg tggggtgcgg tggcggggtg cggtggcgga ggtcccggtg 300 aaatcagggg ctaaggggac ccaaagaagg cgggggatca taggggtgga aagaaagctg 360 agaaccttga gaccggagtg tgaggggcca acggggaagg gcgctagaat tttaaactaa 420 agtagggacc ggaattcccc tggggagatg ttggatggcc ctgtgcactg ccacgggctc 480 tttattcttc gctggttaga aacagacttg tgaaaaagag ttatgcccac tttggggaga 540 cttcgaaaag gttaagaagt tcttacaaga gttctaccag gatgatgaac tcgggaagaa 600 gcagttcaag tatgggaacc agttggttcg gctggctcat cgggaacagg tggctctgta 660 tgtggacctg gacgacgtag ccgaggatga ccccgagttg gtggactcaa tttgtgagaa 720 tgccaggcgc tacgcgaagc tctttgctga tgccgtacaa gagctgctgc ctcagtacaa 780 ggagagggaa gtggtaaata aagatgtcct ggacgtttac attgagcatc ggctaatgat 840 ggagcagcgg agtcgggacc ctgggatggt ccgaagcccc cagaaccagt accctgctga 900 actcatgcgc agattgtgag tggtctctgt cgggaaagat gtagggattg gttctccagg 960 atcttgtttg tgactgtttt ctccccttag tgagctgtat tttcaaggcc ctagcagcaa 1020 caagcctcgt gtgatccggg aagtgcgggc tgactctgtg gggaagttgg taactgtgcg 1080 tggaatcgtc actcgtgtct ctgaagtcaa acccaagatg gtggtggcca cttacacttg 1140 tgaccagtgt ggggcagaga cctaccagcc gatccagtct cccactttca tgcctctgat 1200 catgtgccca agccaggagt gccaaaccaa ccgctcagga gggcggctgt atctgcagac 1260 acggggctcc agattcatca aattccagga gatgaagatg caagaacata gtgatcaggt 1320 gcctgtggga aatatccctc gtagtatcac ggtgctggta gaaggagaga acacaaggat 1380 tgcccagcct ggagaccacg tcagcgtcac tggtattttc ttgccaatcc tgcgcactgg 1440 gttccgacag gtggtacagg gtttactctc agaaacctac ctggaagccc atcggattgt 1500 gaagatgaac aagagtgagg atgatgagtc tggggctgga gagctcacca gggaggagct 1560 gaggcaaatt gcagaggagg atttctacga aaagctggca gcttcaatcg ccccagaaat 1620 atacgggcat gaagatgtga agaaggcact gctgctcctg ctagtcgggg gtgtggacca 1680 gtctcctcga ggcatgaaaa tccggggcaa catcaacatc tgtctgatgg gggatcctgg 1740 tgtggccaag tctcagctcc tgtcatacat tgatcgactg gcgcctcgca gccagtacac 1800 aacaggccgg ggctcctcag gagtggggct tacggcagct gtgctgagag actccgtgag 1860 tggagaactg accttagagg gtggggccct ggtgctggct gaccagggtg tgtgctgcat 1920 tgatgagttc gacaagatgg ctgaggccga ccgcacagcc atccacgagg tcatggagca 1980 gcagaccatc tccattgcca aggccggcat tctcaccaca ctcaatgccc gctgctccat 2040 cctggctgcc gccaaccctg cctacgggcg ctacaaccct cgccgcagcc tggagcagaa 2100 catacagcta cctgctgcac tgctctcccg gtttgacctc ctctggctga ttcaggaccg 2160 gcccgaccga gacaatgacc tacggttggc ccagcacatc acctatgtgc accagcacag 2220 ccggcagccc ccctcccagt ttgaacctct ggacatgaag ctcatgaggc gttacatagc 2280 catgtgccgc gagaagcagc ccatggtgcc agagtctctg gctgactaca tcacagcagc 2340 atacgtggag atgaggcgag aggcttgggc tagtaaggat gccacctata cttctgcccg 2400 gaccctgctg gctatcctgc gcctttccac tgctctggca cgtctgagaa tggtggatgt 2460 ggtggagaaa gaagatgtga atgaagccat caggctaatg gagatgtcaa aggactctct 2520 tctaggagac aaggggcaga cagctaggac tcagagacca gcagatgtga tatttgccac 2580 cgtccgtgaa ctggtctcag ggggccgaag tgtccggttc tctgaggcag agcagcgctg 2640 tgtatctcgt ggcttcacac ccgcccagtt ccaggcggct ctggatgaat atgaggagct 2700 caatgtctgg caggtcaatg cttcccggac acggatcact tttgtctgat tccagcctgc 2760 ttgcaaccct ggggtcctct tgttccctgc tggcctgccc cttgggaagg ggcagtgatg 2820 cctttgaggg gaaggaggag cccctctttc tcccatgctg cacttactcc ttttgctaat 2880 aaaagtgttt gtagattgtc 2900 <210> 68 <211> 2007 <212> DNA <213> Homo sapiens <400> 68 tacttgagca tcggctaatg atggagcagc ggagtcggga ccctgggatg gtccgaagcc 60 cccagaacca gtaccctgct gaactcatgc gcagatttga gctgtatttt caaggcccta 120 gcagcaacaa gcctcgtgtg atccgggaag tgcgggctga ctctgtgggg aagttggtaa 180 ctgtgcgtgg aatcgtcact cgtgtctctg aagtcaaacc caagatggtg gtggccactt 240 acacttgtga ccagtgtggg gcagagacct accagccgat ccagtctccc actttcatgc 300 ctctgatcat gtgcccaagc caggagtgcc aaaccaaccg ctcaggaggg cggctgtatc 360 tgcagacacg gggctccaga ttcatcaaat tccaggagat gaagatgcaa gaacatagtg 420 atcaggtgcc tgtgggaaat atccctcgta gtatcacggt gctggtagaa ggagagaaca 480 caaggattgc ccagcctgga gaccacgtca gcgtcactgg tattttcttg ccaatcctgc 540 gcactgggtt ccgacaggtg gtacagggtt tactctcaga aacctacctg gaagcccatc 600 ggattgtgaa gatgaacaag agtgaggatg atgagtctgg ggctggagag ctcaccaggg 660 aggagctgag gcaaattgca gaggaggatt tctacgaaaa gctggcagct tcaatcgccc 720 cagaaatata cgggcatgaa gatgtgaaga aggcactgct gctcctgcta gtcgggggtg 780 tggaccagtc tcctcgaggc atgaaaatcc ggggcaacat caacatctgt ctgatggggg 840 atcctggtgt ggccaagtct cagctcctgt catacattga tcgactggcg cctcgcagcc 900 agtacacaac aggccggggc tcctcaggag tggggcttac ggcagctgtg ctgagagact 960 ccgtgagtgg agaactgacc ttagagggtg gggccctggt gctggctgac cagggtgtgt 1020 gctgcattga tgagttcgac aagatggctg aggccgaccg cacagccatc cacgaggtca 1080 tggagcagca gaccatctcc attgccaagg ccggcattct caccacactc aatgcccgct 1140 gctccatcct ggctgccgcc aaccctgcct acgggcgcta caaccctcgc cgcagcctgg 1200 agcagaacat acagctacct gctgcactgc tctcccggtt tgacctcctc tggctgattc 1260 aggaccggcc cgaccgagac aatgacctac ggttggccca gcacatcacc tatgtgcacc 1320 agcacagccg gcagcccccc tcccagtttg aacctctgga catgaagctc atgaggcgtt 1380 acatagccat gtgccgcgag aagcagccca tggtgccaga gtctctggct gactacatca 1440 cagcagcata cgtggagatg aggcgagagg cttgggctag taaggatgcc acctatactt 1500 ctgcccggac cctgctggct atcctgcgcc tttccactgc tctggcacgt ctgagaatgg 1560 tggatgtggt ggagaaagaa gatgtgaatg aagccatcag gctaatggag atgtcaaagg 1620 actctcttct aggagacaag gggcagacag ctaggactca gagaccagca gatgtgatat 1680 ttgccaccgt ccgtgaactg gtctcagggg gccgaagtgt ccggttctct gaggcagagc 1740 agcgctgtgt atctcgtggc ttcacacccg cccagttcca ggcggctctg gatgaatatg 1800 aggagctcaa tgtctggcag gtcaatgctt cccggacacg gatcactttt gtctgattcc 1860 agcctgcttg caaccctggg gtcctcttgt tccctgctgg cctgcccctt gggaaggggc 1920 agtgatgcct ttgaggggaa ggaggagccc ctctttctcc catgctgcac ttactccttt 1980 tgctaataaa agtgtttgta gattgtc 2007 <210> 69 <211> 1255 <212> DNA <213> Homo sapiens <400> 69 cactgctgct cctgctagtc gggggtgtgg accagtctcc tcgaggcatg aaaatccggg 60 gcaacatcaa catctgtctg atgggggatc ctggtgtggc caagtctcag ctcctgtcat 120 acattgatcg actggcgcct cgcagccagt acacaacagg ccggggctcc tcaggagtgg 180 ggcttacggc agctgtgctg agagactccg tgagtggaga actgacctta gagggtgggg 240 ccctggtgct ggctgaccag ggtgtgtgct gcattgatga gttcgacaag atggctgagg 300 ccgaccgcac agccatccac gaggtcatgg agcagcagac catctccatt gccaaggccg 360 gcattctcac cacactcaat gcccgctgct ccatcctggc tgccgccaac cctgcctacg 420 ggcgctacaa ccctcgccgc agcctggagc agaacataca gctacctgct gcactgctct 480 cccggtttga cctcctctgg ctgattcagg accggcccga ccgagacaat gacctacggt 540 tggcccagca catcacctat gtgcaccagc acagccggca gcccccctcc cagtttgaac 600 ctctggacat gaagctcatg aggcgttaca tagccatgtg ccgcgagaag cagcccatgg 660 tgccagagtc tctggctgac tacatcacag cagcatacgt ggagatgagg cgagaggctt 720 gggctagtaa ggatgccacc tatacttctg cccggaccct gctggctatc ctgcgccttt 780 ccactgctct ggcacgtctg agaatggtgg atgtggtgga gaaagaagat gtgaatgaag 840 ccatcaggct aatggagatg tcaaaggact ctcttctagg agacaagggg cagacagcta 900 ggactcagag accagcagat gtgatatttg ccaccgtccg tgaactggtc tcagggggcc 960 gaagtgtccg gttctctgag gcagagcagc gctgtgtatc tcgtggcttc acacccgccc 1020 agttccaggc ggctctggat gaatatgagg agctcaatgt ctggcaggtc aatgcttccc 1080 ggacacggat cacttttgtc tgattccagc ctgcttgcaa ccctggggtc ctcttgttcc 1140 ctgctggcct gccccttggg aaggggcagt gatgcctttg aggggaagga ggagcccctc 1200 tttctcccat gctgcactta ctccttttgc taataaaagt gtttgtagat tgtca 1255 <210> 70 <211> 2427 <212> DNA <213> Homo sapiens <400> 70 gacgtttcgc gccaatttcg gttggccggc cacagtccac cgcgcggaga ttctcagctt 60 ccccaggagc aagacctctg agcccgccaa gcgcggccgc acggccctcg gcagcgatgg 120 cactgaagga ctacgcgcta gagaaggaaa aggttaagaa gttcttacaa gagttctacc 180 aggatgatga actcgggaag aagcagttca agtatgggaa ccagttggtt cggctggctc 240 atcgggaaca ggtggctctg tatgtggacc tggacgacgt agccgaggat gaccccgagt 300 tggtggactc aatttgtgag aatgccaggc gctacgcgaa gctctttgct gatgccgtac 360 aagagctgct gcctcagtac aaggagaggg aagtggtaaa taaagatgtc ctggacgttt 420 acattgagca tcggctaatg atggagcagc ggagtcggga ccctgggatg gtccgaagcc 480 cccagaacca gtaccctgct gaactcatgc gcagatttga gctgtatttt caaggcccta 540 gcagcagcaa gcctcgtgtg atccgggaag tgcgggctga ctctgtgggg aagttggtaa 600 ctgtgcgtgg aatcgtcact cgtgtctctg aagtcaaacc caagatggtg gtggccactt 660 acacttgtga ccagtgtggg gcagagacct accagccgat ccagtctccc actttcatgc 720 ctctgatcat gtgcccaagc caggagtgcc aaaccaaccg ctcaggaggg cggctgtatc 780 tgcagacacg gggctccaga ttcatcaaat tccaggagat gaagatgcaa gaacatagtg 840 atcaggtgcc tgtgggaaat atccctcgta gtatcacggt gctggtagaa ggagagaaca 900 caaggattgc ccagcctgga gaccacgtca gcgtcactgg tattttcttg ccaatcctgc 960 gcactgggtt ccgacaggtg gtacagggtt tactctcaga aacctacctg gaagcccatc 1020 ggattgtgaa gatgaacaag agtgaggatg atgagtctgg ggctggagag ctcaccaggg 1080 aggagctgag gcaaattgca gaggaggatt tctacgaaaa gctggcagct tcaatcgccc 1140 cagaaatata cgggcatgaa gatgtgaaga aggcactgct gctcctgcta gtcgggggtg 1200 tggaccagtc tcctcgaggc atgaaaatcc ggggcaacat caacatctgt ctgatggggg 1260 atcctggtgt ggccaagtct cagctcctgt catacattga tcgactggcg cctcgcagcc 1320 agtacacaac aggccggggc tcctcaggag tggggcttac ggcagctgtg ctgagagact 1380 ccgtgagtgg agaactgacc ttagagggtg gggccctggt gctggctgac cagggtgtgt 1440 gctgcattga tgagttcgac aagatggctg aggccgaccg cacagccatc cacgaggtca 1500 tggagcagca gaccatctcc attgccaagg ccggcattct caccacactc aatgcccgct 1560 gctccatcct ggctgccgcc aaccctgcct acgggcgcta caaccctcgc cgcagcctgg 1620 agcagaacat acagctacct gctgcactgc tctcccggtt tgacctcctc tggctgattc 1680 aggaccggcc cgaccgagac aatgacctac ggttggccca gcacatcacc tatgtgcacc 1740 agcacagccg gcagcccccc tcccagtttg aacctctgga catgaagctc atgaggcgtt 1800 acatagccat gtgccgcgag aagcagccca tggtgccaga gtctctggct gactacatca 1860 cagcagcata cgtggagatg aggcgagagg cttgggctag taaggatgcc acctatactt 1920 ctgcccggac cctgctggct atcctgcgcc tttccactgc tctggcacgt ctgagaatgg 1980 tggatgtggt ggagaaagaa gatgtgaatg aagccatcag gctaatggag atgtcaaagg 2040 actctcttct aggagacaag gggcagacag ctaggactca gagaccagca gatgtgatat 2100 ttgccaccgt ccgtgaactg gtctcagggg gccgaagtgt ccggttctct gaggcagagc 2160 agcgctgtgt atctcgtggc ttcacacccg cccagttcca ggcggctctg gatgaatatg 2220 aggagctcaa tgtctggcag gtcaatgctt cccggacacg gatcactttt gtctgattcc 2280 agcctgcttg caaccctggg gtcctcttgt tccctgctgg cctgcccctt gggaaggggc 2340 agtgatgcct ttgaggggaa ggaggagccc ctctttctcc catgctgcac ttactccttt 2400 tgctaataaa agtgtttgta gattgtc 2427 <210> 71 <211> 2321 <212> DNA <213> Homo sapiens <400> 71 tcggttggcc ggccacagtc caccgcgcgg agattctcag cttccccagg agcaagacct 60 ctgagcccgc caagcgcggc cgcacggccc tcggcagcga tggcactgaa ggactacgcg 120 ctagagaagg aaaaggttaa gaagttctta caagagttct accaggatga tgaactcggg 180 aagaagcagt tcaagtatgg gaaccagttg gttcggctgg ctcatcggga acaggtggct 240 ctgtatgtgg acctggacga cgtagcctca gtacaaggag agggaagtgg taaataaaga 300 tgtcctggac gtttacattg agcatcggct aatgatggag cagcggagtc gggaccctgg 360 gatggtccga agcccccaga accagtaccc tgctgaactc atgcgcagat ttgagctgta 420 ttttcaaggc cctagcagca gcaagcctcg tgtgatccgg gaagtgcggg ctgactctgt 480 ggggaagttg gtaactgtgc gtggaatcgt cactcgtgtc tctgaagtca aacccaagat 540 ggtggtggcc acttacactt gtgaccagtg tggggcagag acctaccagc cgatccagtc 600 tcccactttc atgcctctga tcatgtgccc aagccaggag tgccaaacca accgctcagg 660 agggcggctg tatctgcaga cacggggctc cagattcatc aaattccagg agatgaagat 720 gcaagaacat agtgatcagg tgcctgtggg aaatatccct cgtagtatca cggtgctggt 780 agaaggagag aacacaagga ttgcccagcc tggagaccac gtcagcgtca ctggtatttt 840 cttgccaatc ctgcgcactg ggttccgaca ggtggtacag ggtttactct cagaaaccta 900 cctggaagcc catcggattg tgaagatgaa caagagtgag gatgatgagt ctggggctgg 960 agagctcacc agggaggagc tgaggcaaat tgcagaggag gatttctacg aaaagctggc 1020 agcttcaatc gccccagaaa tatacgggca tgaagatgtg aagaaggcac tgctgctcct 1080 gctagtcggg ggtgtggacc agtctcctcg aggcatgaaa atccggggca acatcaacat 1140 ctgtctgatg ggggatcctg gtgtggccaa gtctcagctc ctgtcataca ttgatcgact 1200 ggcgcctcgc agccagtaca caacaggccg gggctcctca ggagtggggc ttacggcagc 1260 tgtgctgaga gactccgtga gtggagaact gaccttagag ggtggggccc tggtgctggc 1320 tgaccagggt gtgtgctgca ttgatgagtt cgacaagatg gctgaggccg accgcacagc 1380 catccacgag gtcatggagc agcagaccat ctccattgcc aaggccggca ttctcaccac 1440 actcaatgcc cgctgctcca tcctggctgc cgccaaccct gcctacgggc gctacaaccc 1500 tcgccgcagc ctggagcaga acatacagct acctgctgca ctgctctccc ggtttgacct 1560 cctctggctg attcaggacc ggcccgaccg agacaatgac ctacggttgg cccagcacat 1620 cacctatgtg caccagcaca gccggcagcc cccctcccag tttgaacctc tggacatgaa 1680 gctcatgagg cgttacatag ccatgtgccg cgagaagcag cccatggtgc cagagtctct 1740 ggctgactac atcacagcag catacgtgga gatgaggcga gaggcttggg ctagtaagga 1800 tgccacctat acttctgccc ggaccctgct ggctatcctg cgcctttcca ctgctctggc 1860 acgtctgaga atggtggatg tggtggagaa agaagatgtg aatgaagcca tcaggctaat 1920 ggagatgtca aaggactctc ttctaggaga caaggggcag acagctagga cccagagacc 1980 agcagatgtg atatttgcca ccgtccgtga actggtctca gggggccgaa gtgtccggtt 2040 ctctgaggca gagcagcgct gtgtatctcg tggcttcaca cccgcccagt tccaggcggc 2100 tctggatgaa tatgaggagc tcaatgtctg gcaggtcaat gcttcccgga cacggatcac 2160 ttttgtctga ttccagcctg cttgcaaccc tggggtcctc ttgttccctg ctggcctgcc 2220 ccttgggaag gggcagtgat gcctttgagg ggaaggagga gcccctcttt ctcccatgct 2280 gcacttactc cttttgctaa taaaagtgtt tgtagattgt c 2321 <210> 72 <211> 3769 <212> DNA <213> Homo sapiens <400> 72 aaagctgcag cgtctggaaa aaagcgactt gtggcggtcg agcgtggcgc aggcgaatcc 60 tcggcactaa gcaaatatgg acctcgcggc ggcagcggag ccgggcgccg gcagccagca 120 cctggaggtc cgcgacgagg tggccgagaa gtgccagaaa ctgttcctgg acttcttgga 180 ggagtttcag agcagcgatg gagaaattaa atacttgcaa ttagcagagg aactgattcg 240 tcctgagaga aacacattgg ttgtgagttt tgtggacctg gaacaattta accagcaact 300 ttccaccacc attcaagagg agttctatag agtttaccct tacctgtgtc gggccttgaa 360 aacattcgtc aaagaccgta aagagatccc tcttgccaag gatttttatg ttgcattcca 420 agacctgcct accagacaca agattcgaga gctcacctca tccagaattg gtttgctcac 480 tcgcatcagt gggcaggtgg tgcggactca cccagttcac ccagagcttg tgagcggaac 540 ttttctgtgc ttggactgtc agacagtgat cagggatgta gaacagcagt tcaaatacac 600 acagccaaac atctgccgaa atccagtttg tgccaacagg aggagattct tactggatac 660 aaataaatca agatttgttg attttcaaaa ggttcgtatt caagagaccc aagctgagct 720 tcctcgaggg agtatccccc gcagtttaga agtaatttta agggctgaag ctgtggaatc 780 agctcaagct ggtgacaagt gtgactttac agggacactg attgttgtgc ctgacgtctc 840 caagcttagc acaccaggag cacgtgcaga aactaattcc cgtgtcagtg gtgttgatgg 900 atatgagaca gaaggcattc gaggactccg ggcccttggt gttagggacc tttcttatag 960 gctggtcttt cttgcctgct gtgttgcgcc aaccaaccca aggtttgggg ggaaagagct 1020 cagagatgag gaacagacag ctgagagcat taagaaccaa atgactgtga aagaatggga 1080 gaaagtgttt gagatgagtc aagataaaaa tctataccac aatctttgta ccagcctgtt 1140 ccctactata catggcaatg atgaagtaaa acggggtgtc ctgctgatgc tctttggtgg 1200 cgttccaaag acaacaggag aagggacctc tcttcgaggg gacataaatg tttgcattgt 1260 tggtgaccca agtacagcta agagccaatt tctcaagcac gtggaggagt tcagccccag 1320 agctgtctac accagtggta aagcgtccag tgctgctggc ttaacagcag ctgttgtgag 1380 agatgaagaa tctcatgagt ttgtcattga ggctggagct ttgatgttgg ctgataatgg 1440 tgtgtgttgt attgatgaat ttgataagat ggacgtgcgg gatcaagttg ctattcatga 1500 agctatggaa cagcagacca tatccatcac taaagcagga gtgaaggcta ctctgaacgc 1560 ccggacgtcc attttggcag cagcaaaccc aatcagtgga cactatgaca gatcaaaatc 1620 attgaaacag aatataaatt tgtcagctcc catcatgtcc cgattcgatc tcttctttat 1680 ccttgtggat gaatgtaatg aggttacaga ttatgccatt gccaggcgca tagtagattt 1740 gcattcaaga attgaggaat caattgatcg tgtctattcc ctcgatgata tcagaagata 1800 tcttctcttt gcaagacagt ttaaacccaa gatttccaaa gagtcagagg acttcattgt 1860 ggagcaatat aaacatctcc gccagagaga tggttctgga gtgaccaagt cttcatggag 1920 gattacagtg cgacagcttg agagcatgat tcgtctctct gaagctatgg ctcggatgca 1980 ctgctgtgat gaggtccaac ctaaacatgt gaaggaagct ttccggttac tgaataaatc 2040 aatcatccgt gtggaaacac ctgatgtcaa tctagatcaa gaggaagaga tccagatgga 2100 ggtagatgag ggtgctggtg gcatcaatgg tcatgctgac agccctgctc ctgtgaacgg 2160 gatcaatggc tacaatgaag acataaatca agagtctgct cccaaagcct ccttaaggct 2220 gggcttctct gagtactgcc gaatctctaa ccttattgtg cttcacctca gaaaggtgga 2280 agaagaagag gacgagtcag cattaaagag gagcgagctt gttaactggt acttgaagga 2340 aatcgaatca gagatagact ctgaagaaga acttataaat aaaaaaagaa tcatagagaa 2400 agttattcat cgactcacac actatgatca tgttctaatt gagctcaccc aggctggatt 2460 gaaaggctcc acagagggaa gtgagagcta tgaagaagat ccctacttgg tagttaaccc 2520 taactacttg ctcgaagatt gagatagtga aagtaactga ccagagctga ggaactgtgg 2580 cacagcacct cgtggcctgg agcctggctg gagctctgct agggacagaa gtgtttctgg 2640 aagtgatgct tccaggattt gttttcagaa acaagaattg agttgatggt cctatgtgtc 2700 acattcatca caggtttcat accaacacag gcttcagcac ttcctttggt gtgtttcctg 2760 tcccagtgaa gttggaacca aataatgtgt agtctctata accaatacct ttgttttcat 2820 gtgtaagaaa aggcccatta cttttaaggt atgtgctgtc ctattgagca aataactttt 2880 tttcaattgc cagctactgc ttttattcat caaaataaaa taacttgttc tgaagttgtc 2940 tattggattt ctttctactg taccctgatt attacttcca tctacttctg aatgtgagac 3000 tttccctttt tgcttaacct ggagtgaaga ggtagaactg tggtattatg gatgaggttt 3060 ctatgagaag gagtcattag agaactcata tgaaagctag aggccttaga gatgactttc 3120 caaggttaat tccagttgtt tttttttttt tttaagttta taaaagttta ttatactttt 3180 ttaaaattac tctttagtaa tttattttac ttctgtgtcc taagggtaat ttctcaggat 3240 tgttttcaaa ttgctttttt aggggaaata ggtcatttgc tatattacaa gcaatcccca 3300 aattttatgg tcttccagga aaagttatta ccgtttatga tactaacagt tcctgagact 3360 tagctatgat cagtatgttc atgaggtgga gcagttcctg tgttgcagct tttaacaaca 3420 gatggcattc attaaatcac aaagtatgtt aaaggtcaca aaagcaaaat aactgtctga 3480 ggctaaggcc cacgtgggac agtctaatac ccatgagtac tcaacttgcc ttgatgtctg 3540 agctttccag tgcaatgtga atttgagcag ccagaaatct attagtagaa agcaagacag 3600 attaatatag gttaaaacaa tgatttaaat atgtttctcc caataattat ctctttccct 3660 ggaatcaact tgtatgaaac cttgtcaaaa tgtactccac aagtatgtac aattaagtat 3720 tttaaaaata aatggcaaac attaaaaaca aaaaaaaaaa aaaaaaaaa 3769 <210> 73 <211> 2923 <212> DNA <213> Homo sapiens <400> 73 gtcgagcgtg gcgtaggcga atcctcggca ctaagcaaat atggacctcg cggcggcagc 60 ggagccgggc gccggcagcc agcacctgga ggtccgcgac gaggtggccg agaagtgcca 120 gaaactgttc ctggacttct tggaggagtt tcagagcagc gatggagaaa ttaaatactt 180 gcaattagca gaggaactga ttcgtcctga gagaaacaca ttggttgtga gttttgtgga 240 cctggaacaa tttaaccagc aactttccac caccattcaa gaggagttct atagagttta 300 cccttacctg tgtcgggcct tgaaaacatt cgtcaaagac cgtaaagaga tccctcttgc 360 caaggatttt tatgttgcat tccaagacct gcctaccaga cacaagattc gagagctcac 420 ctcatccaga attggtttgc tcactcgcat cagtgggcag gtggtgcgga ctcacccagt 480 tcacccagag cttgtgagcg gaacttttct gtgcttggac tgtcagacag tgatcaggga 540 tgtagaacag cagttcaaat acacacagcc aaacatctgc cgaaatccag tttgtgccaa 600 caggaggaga ttcttactgg atacaaataa atcaagattt gttgattttc aaaaggttcg 660 tattcaagag acccaagctg agcttcctcg agggagtatc ccccgcagtt tagaagtaat 720 tttaagggct gaagctgtgg aatcagctca agctggtgac aagtgtgact ttacagggac 780 actgattgtt gtgcctgacg tctccaagct tagcacacca ggagcacgtg cagaaactaa 840 ttcccgtgtc agtggtgttg atggatatga gacagaaggc attcgaggac tccgggccct 900 tggtgttagg gacctttctt ataggctggt ctttcttgcc tgctgtgttg cgccaaccaa 960 cccaaggttt ggggggaaag agctcagaga tgaggaacag acagctgaga gcattaagaa 1020 ccaaatgact gtgaaagaat gggagaaagt gtttgagatg agtcaagata aaaatctata 1080 ccacaatctt tgtaccagcc tgttccctac tatacatggc aatgatgaag taaaacgggg 1140 tgtcctgctg atgctctttg gtggcgttcc aaagacaaca ggagaaggga cctctcttcg 1200 aggggacata aatgtttgca ttgttggtga cccaagtaca gctaagagcc aatttctcaa 1260 gcacgtggag gagttcagcc ccagagctgt ctacaccagt ggtaaagcgt ccagtgctgc 1320 tggcttaaca gcagctgttg tgagagatga agaatctcat gagtttgtca ttgaggctgg 1380 agctttgatg ttggctgata atggtgtgtg ttgtattgat gaatttgata agatggacgt 1440 gcgggatcaa gttgctattc atgaagctat ggaacagcag accatatcca tcactaaagc 1500 aggagtgaag gctactctga acgcccggac gtccattttg gcagcagcaa acccaatcag 1560 tggacactat gacagatcaa aatcattgaa acagaatata aatttgtcag ctcccatcat 1620 gtcccgattc gatctcttct ttatccttgt ggatgaatgt aatgaggtta cagattatgc 1680 cattgccagg cgcatagtag atttgcattc aagaattgag gaatcaattg atcgtgtcta 1740 ttccctcgat gatatcagaa gatatcttct ctttgcaaga cagtttaaac ccaagatttc 1800 caaagagtca gaggacttca ttgtggagca atataaacat ctccgccaga gagatggttc 1860 tggagtgacc aagtcttcat ggaggattac agtgcgacag cttgagagca tgattcgtct 1920 ctctgaagct atggctcgga tgcactgctg tgatgaggtc caacctaaac atgtgaagga 1980 agctttccgg ttactgaata aatcaatcat ccgtgtggaa acacctgatg tcaatctaga 2040 tcaagaggaa gagatccaga tggaggtaga tgagggtgct ggtggcatca atggtcatgc 2100 tgacagccct gctcctgtga acgggatcaa tggctacaat gaagacataa atcaagagtc 2160 tgctcccaaa gcctccttaa ggctgggctt ctctgagtac tgccgaatct ctaaccttat 2220 tgtgcttcac ctcagaaagg tggaagaaga agaggacgag tcagcattaa agaggagcga 2280 gcttgttaac tggtacttga aggaaatcga atcagagata gactctgaag aagaacttat 2340 aaataaaaaa agaatcatag agaaagttat tcatcgactc acacactatg atcatgttct 2400 aattgagctc acccaggctg gattgaaagg ctccacagag ggaagtgaga gctatgaaga 2460 agatccctac ttggtagtta accctaacta cttgctcgaa gattgagata gtgaaagtaa 2520 ctgaccagag ctgaggaact gtggcacagc acctcgtggc ctggagcctg gctggagctc 2580 tgctagggac agaagtgttt ctggaagtga tgcttccagg atttgttttc agaaacaaga 2640 attgagttga tggtcctatg tgtcacattc atcacaggtt tcataccaac acaggcttca 2700 gcacttcctt tggtgtgttt cctgtcccag tgaagttgga accaaataat gtgtagtctc 2760 tataaccaat acctttgttt tcatgtgtaa gaaaaggccc attactttta aggtatgtgc 2820 tgtcctattg agcaaataac tttttttcaa ttgccagcta ctgcttttat tcatcaaaat 2880 aaaataactt gttctgaaaa aaaaaaaaaa aaaaaaaaaa aaa 2923 <210> 74 <211> 2917 <212> DNA <213> Homo sapiens <400> 74 ggaaaaaagc gacttgtggc ggtcgagcgt ggcgcaggcg aatcctcggc actaagcaaa 60 tatggacctc gcggcggcag cggagccggg cgccggcagc cagcacctgg aggtccgcga 120 cgaggtggcc gagaagtgcc agaaactgtt cctggacttc ttggaggagt ttcagagcag 180 cgatggagaa attaaatact tgcaattagc agaggaactg attcgtcctg agagaaacac 240 attggttgtg agttttgtgg acctggaaca atttaaccag caactttcca ccaccattca 300 agaggagttc tatagagttt acccttacct gtgtcgggcc ttgaaaacat tcgtcaaaga 360 ccgtaaagag atccctcttg ccaaggattt ttatgttgca ttccaagacc tgcctaccag 420 acacaagatt cgagagctca cctcatccag aattggtttg ctcactcgca tcagtgggca 480 ggtggtgcgg actcacccag ttcacccaga gcttgtgagc ggaacttttc tgtgcttgga 540 ctgtcagaca gtgatcaggg atgtagaaca gcagttcaaa tacacacagc caaacatctg 600 ccgaaatcca gtttgtgcca acaggaggag attcttactg gatacaaata aatcaagatt 660 tgttgatttt caaaaggttc gtattcaaga gacccaagct gagcttcctc gagggagtat 720 cccccgcagt ttagaagtaa ttttaagggc tgaagctgtg gaatcagctc aagctggtga 780 caagtgtgac tttacaggga cactgattgt tgtgcctgac gtctccaagc ttagcacacc 840 aggagcacgt gcagaaacta attcccgtgt cagtggtgtt gatggatatg agacagaagg 900 cattcgagga ctccgggccc ttggtgttag ggacctttct tataggctgg tctttcttgc 960 ctgctgtgtt gcgccaacca acccaaggtt tggggggaaa gagctcagag atgaggaaca 1020 gacagctgag agcattaaga accaaatgac tgtgaaagaa tgggagaaag tgtttgagat 1080 gagtcaagat aaaaatctat accacaatct ttgtaccagc ctgttcccta ctatacatgg 1140 caatgatgaa gtaaaacggg gtgtcctgct gatgctcttt ggtggcgttc caaagacaac 1200 aggagaaggg acctctcttc gaggggacat aaatgtttgc attgttggtg acccaagtac 1260 agctaagagc caatttctca agcacgtgga ggagttcagc cccagagctg tctacaccag 1320 tggtaaagcg tccagtgctg ctggcttaac agcagctgtt gtgagagatg aagaatctca 1380 tgagtttgtc attgaggctg gagctttgat gttggctgat aatggtgtgt gttgtattga 1440 tgaatttgat aagatggacg tgcgggatca agttgctatt catgaagcta tggaacagca 1500 gaccatatcc atcactaaag caggagtgaa ggctactctg aacgcccgga cgtccatttt 1560 ggcagcagca aacccaatca gtggacacta tgacagatca aaatcattga aacagaatat 1620 aaatttgtca gctcccatca tgtcccgatt cgatctcttc tttatccttg tggatgaatg 1680 taatgaggtt acagattatg ccattgccag gcgcatagta gatttgcatt caagaattga 1740 ggaatcaatt gatcgtgtct attccctcga tgatatcaga agatatcttc tctttgcaag 1800 acagtttaaa cccaagattt ccaaagagtc agaggacttc attgtggagc aatataaaca 1860 tctccgccag agagatggtt ctggagtgac caagtcttca tggaggatta cagtgcgaca 1920 gcttgagagc atgattcgtc tctctgaagc tatggctcgg atgcactgct gtgatgaggt 1980 ccaacctaaa catgtgaagg aagctttccg gttactgaat aaatcaatca tccgtgtgga 2040 aacacctgat gtcaatctag atcaagagga agagatccag atggaggtag atgagggtgc 2100 tggtggcatc aatggtcatg ctgacagccc tgctcctgtg aacgggatca atggctacaa 2160 tgaagacata aatcaagagt ctgctcccaa agcctcctta aggctgggct tctctgagta 2220 ctgccgaatc tctaacctta ttgtgcttca cctcagaaag gtggaagaag aagaggacga 2280 gtcagcatta aagaggagcg agcttgttaa ctggtacttg aaggaaatcg aatcagagat 2340 agactctgaa gaagaactta taaataaaaa aagaatcata gagaaagtta ttcatcgact 2400 cacacactat gatcatgttc taattgagct cacccaggct ggattgaaag gctccacaga 2460 gggaagtgag agctatgaag aagatcccta cttggtagtt aaccctaact acttgctcga 2520 agattgagat agtgaaagta actgaccaga gctgaggaac tgtggcacag cacctcgtgg 2580 cctggagcct ggctggagct ctgctaggga cagaagtgtt tctggaagtg atgcttccag 2640 gatttgtttt cagaaacaag aattgagttg atggtcctat gtgtcacatt catcacaggt 2700 ttcataccaa cacaggcttc agcacttcct ttggtgtgtt tcctgtccca gtgaagttgg 2760 aaccaaataa tgtgtagtct ctataaccaa tacctttgtt ttcatgtgta agaaaaggcc 2820 cattactttt aaggtatgtg ctgtcctatt gagcaaataa ctttttttca attgccagct 2880 actgctttta ttcatcaaaa taaaataact tgttctg 2917 <210> 75 <211> 3744 <212> DNA <213> Homo sapiens <400> 75 ccacgcgtcc ggtggcggtc gagcgtggcg taggcgaatc ctcggcacta agcatatgga 60 cctcgcggcg gcagcggagc cgggcgccgg cagccagcac ctggaggtcc gcgacgaggt 120 ggccgagaag tgccagaaac tgttcctgga cttcttggag gagtttcaga gcagcgatgg 180 agaaattaaa tacttgcaat tagcagagga actgattcgt cctgagagaa acacattggt 240 tgtgagtttt gtggacctgg aacaatttaa ccagcaactt tccaccacca ttcaagagga 300 gttctataga gtttaccctt acctgtgtcg ggccttgaaa acattcgtca aagaccgtaa 360 agagatccct cttgccaagg atttttatgt tgcattccaa gacctgccta ccagacacaa 420 gattcgagag ctcacctcat ccagaattgg tttgctcact cgcatcagtg ggcaggtggt 480 gcggactcac ccagttcacc cagagcttgt gagcggaact tttctgtgct tggactgtca 540 gacagtgatc agggatgtag aacagcagtt caaatacaca cagccaaaca tctgccgaaa 600 tccagtttgt gccaacagga ggagattctt actggataca aataaatcaa gatttgttga 660 ttttcaaaag gttcgtattc aagagaccca agctgagctt cctcgaggga gtatcccccg 720 cagtttagaa gtaattttaa gggctgaagc tgtggaatca gctcaagctg gtgacaagtg 780 tgactttaca gggacactga ttgttgtgcc tgacgtctcc aagcttagca caccaggagc 840 acgtgcagaa actaattccc gtgtcagtgg tgttgatgga tatgagacag aaggcattcg 900 aggactccgg gcccttggtg ttagggacct ttcttatagg ctggtctttc ttgcctgctg 960 tgttgcgcca accaacccaa ggtttggggg gaaagagctc agagatgagg aacagacagc 1020 tgagagcatt aagaaccaaa tgactgtgaa agaatgggag aaagtgtttg agatgagtca 1080 agataaaaat ctataccaca atctttgtac cagcctgttc cctactatac atggcaatga 1140 tgaagtaaaa cggggtgtcc tgctgatgct ctttggtggc gttccaaaga caacaggaga 1200 agggacctct cttcgagggg acataaatgt ttgcattgtt ggtgacccaa gtacagctaa 1260 gagccaattt ctcaagcacg tggaggagtt cagccccaga gctgtctaca ccagtggtaa 1320 agcgtccagt gctgctggct taacagcagc tgttgtgaga gatgaagaat ctcatgagtt 1380 tgtcattgag gctggagctt tgatgttggc tgataatggt gtgtgttgta ttgatgaatt 1440 tgataagatg gacgtgcggg atcaagttgc tattcatgaa gctatggaac agcagaccat 1500 atccatcact aaagcaggag tgaaggctac tctgaacgcc cggacgtcca ttttggcagc 1560 agcaaaccca atcagtggac actatgacag atcaaaatca ttgaaacaga atataaattt 1620 gtcagctccc atcatgtccc gattcgatct cttctttatc cttgtggatg aatgtaatga 1680 ggttacagat tatgccattg ccaggcgcat agtagatttg cattcaagaa ttgaggaatc 1740 aattgatcgt gtctattccc tcgatgatat cagaagatat cttctctttg caagacagtt 1800 taaacccaag atttccaaag agtcagagga cttcattgtg gagcaatata aacatctccg 1860 ccagagagat ggttctggag tgaccaagtc ttcatggagg attacagtgc gacagcttga 1920 gagcatgatt cgtctctctg aagctatggc tcggatgcac tgctgtgatg aggtccaacc 1980 taaacatgtg aaggaagctt tccggttact gaataaatca atcatccgtg tggaaacacc 2040 tgatgtcaat ctagatcaag aggaagagat ccagatggag gtagatgagg gtgccggtgg 2100 catcaatggt catgctgaca gccctgctcc tgtgaacggg atcaatggct acaatgaaga 2160 cataaatcaa gagtctgctc ccaaagcctc cttaaggctg ggcttctctg agtactgccg 2220 aatctctaac cttattgtgc ttcacctcag aaaggtggaa gaagaagagg acgagtcagc 2280 attaaagagg agcgagcttg ttaactggta cttgaaggaa atcgaatcag agatagactc 2340 tgaagaagaa cttataaata aaaaaagaat catagagaaa gttattcatc gactcacaca 2400 ctatgatcat gttctaattg agctcaccca ggctggattg aaaggctcca cagagggaag 2460 tgagagctat gaagaagatc cctacttggt agttaaccct aactacttgc tcgaagattg 2520 agatagtgaa agtaactgac cagagctgag gaactgtggc acagcacctc gtggcctgga 2580 gcctggctgg agctctgcta gggacagaag tgtttctgga agtgatgctt ccaggatttg 2640 ttttcagaaa caagaattga gttgatggtc ctatgtgtca cattcatcac aggtttcata 2700 ccaacacagg cttcagcact tcctttggtg tgtttcctgt cccagtgaag ttggaaccaa 2760 ataatgtgta gtctctataa ccaatacctt tgttttcatg tgtaagaaaa ggcccattac 2820 ttttaaggta tgtgctgtcc tattgagcaa ataacttttt ttcaattgcc agctactgct 2880 tttattcatc aaaataaaat aacttgttct gaagttgtct attggatttc tttctactgt 2940 accctgatta ttacttccat ctacttctga atgtgagact ttcccttttt gcttaacctg 3000 gagtgaagag gtagaactgt ggtattatgg atgaggtttc tatgagaagg agtcattaga 3060 gaactcatat gaaagctaga ggccttagag atgactttcc aaggttaatt ccagtttttt 3120 ttttttttaa gtttataaaa gtttattata cttttttaaa attactcttt agtaatttat 3180 tttacttctg tgtcctaagg gtaatttctc aggattgttt tcaaattgct tttttagggg 3240 aaataggtca tttgctatat tacaagcaat ccccaaattt tatggtcttc caggaaaagt 3300 tattaccgtt tatgatacta acagttcctg agacttagct atgatcagta tgttcatgag 3360 gtggagcagt tcctgtgttg cagcttttaa caacagatgg cattcattaa atcacaaagt 3420 atgttaaagg tcacaaaagc aaaataactg tctgaggcta aggcccacgt gggacagtct 3480 aatacccatg agtactcaac ttgccttgat gtctgagctt tccagtgcaa tgtgaatttg 3540 agcagccaga aatctattag tagaaagcaa gacagattaa tataggttaa aacaatgatt 3600 taaatatgtt tctcccaata attatctctt tccctggaat caacttgtat gaaaccttgt 3660 caaaatgtac tccacaagta tgtacaatta agtattttaa aaataaatgg caaacattaa 3720 aaaaaaaaaa aaaaaaaaaa aaaa 3744 <210> 76 <211> 2913 <212> DNA <213> Homo sapiens <400> 76 cttgtggcgg tcgagcgtgg cgtaggcgaa tcctcggcac taagcaaata tggacctcgc 60 ggcggcagcg gagccgggcg ccggcagcca gcacctggag gtccgcgacg aggtggccga 120 gaagtgccag aaactgttcc tggacttctt ggaggagttt cagagcagcg atggagaaat 180 taaatacttg caattagcag aggaactgat tcgtcctgag agaaacacat tggttgtgag 240 ttttgtggac ctggaacaat ttaaccagca actttccacc accattcaag aggagttcta 300 tagagtttac ccttacctgt gtcgggcctt gaaaacattc gtcaaagacc gtaaagagat 360 ccctcttgcc aaggattttt atgttgcatt ccaagacctg cctaccagac acaagattcg 420 agagctcacc tcatccagaa ttggtttgct cactcgcatc agtgggcagg tggtgcggac 480 tcacccagtt cacccagagc ttgtgagcgg aacttttctg tgcttggact gtcagacagt 540 gatcagggat gtagaacagc agttcaaata cacacagcca aacatctgcc gaaatccagt 600 ttgtgccaac aggaggagat tcttactgga tacaaataaa tcaagatttg ttgattttca 660 aaaggttcgt attcaagaga cccaagctga gcttcctcga gggagtatcc cccgcagttt 720 agaagtaatt ttaagggctg aagctgtgga atcagctcaa gctggtgaca agtgtgactt 780 tacagggaca ctgattgttg tgcctgacgt ctccaagctt agcacaccag gagcacgtgc 840 agaaactaat tcccgtgtca gtggtgttga tggatatgag acagaaggca ttcgaggact 900 ccgggccctt ggtgttaggg acctttctta taggctggtc tttcttgcct gctgtgttgc 960 gccaaccaac ccaaggtttg gggggaaaga gctcagagat gaggaacaga cagctgagag 1020 cattaagaac caaatgactg tgaaagaatg ggagaaagtg tttgagatga gtcaagataa 1080 aaatctatac cacaatcttt gtaccagcct gttccctact atacatggca atgatgaagt 1140 aaaacggggt gtcctgctga tgctctttgg tggcgtttcc aaagacaaca ggagaaggga 1200 cctctcttca ggggacataa atgtttgcat tgttggtgac ccaagtacag ctaagagcca 1260 atttctcaag cacgtggagg agttcagccc cagagctgtc tacaccagtg gtaaagcgtc 1320 cagtgctgct ggcttaacag cagctgttgt gagagatgaa gaatctcatg agtttgtcat 1380 tgaggctgga gctttgatgt tggctgataa tggtgtgtgt tgtattgatg aatttgataa 1440 gatggacgtg cgggatcaag ttgctattca tgaagctatg gaacagcaga ccatatccat 1500 cactaaagca ggagtgaagg ctactctgaa cacccggacg tccattttgg cagcagcaaa 1560 cccaatcagt ggacactatg acagatcaaa atcattgaaa cagaatataa atttgtcagc 1620 tcccatcatg tcccgattcg atctcttctt tatccttgtg gatgaatgta atgaggttac 1680 agattatgcc attgccaggc gcatagtaga tttgcattca agaattgagg aatcaattga 1740 tcgtgtctat tccctcgatg atatcagaag atatcttctc tttgcaagac agtttaaacc 1800 caagatttcc aaagagtcag aggacttcat tgtggagcaa tataaacatc tccgccagag 1860 agatggttct ggagtgacca agtcttcatg gaggattaca gtgcgacagc ttgagagcat 1920 gattcgtctc tctgaagcta tggctcggat gcactgctgt gatgaggtcc aacctaaaca 1980 tgtgaaggaa gctttccggt tactgaataa atcaatcatc cgtgtggaaa cacctgatgt 2040 caatctagat caagaggaag agatccagat ggaggtagat gagggtgctg gtggcatcaa 2100 tggtcatgct gacagccctg ctcctgtgaa cgggatcaat ggctacaatg aagacataaa 2160 tcaagagtct gctcccaaag cctccttaag gctgggcttc tctgagtact gccgaatctc 2220 taaccttatt gtgcttcacc tcagaaaggt ggaagaagaa gaggacgagt cagcattaaa 2280 gaggagcgag cttgttaact ggtacttgaa ggaaatcgaa tcagagatag actctgaaga 2340 agaacttata aataaaaaaa gaatcataga gaaagttatt catcgactca cacactatga 2400 tcatgttcta attgagccca cccaggctgg attgaaaggc tccacagagg gaagtgagag 2460 ctatgaagaa gatccctact tggtagttaa ccctaactac ttgctcgaag attgagatag 2520 tgaaagtaac tgaccagagc tgaggaactg tggcacagca cctcgtggcc tggagcctgg 2580 ctggagctct gctagggaca gaagtgtttc tggaagtgat gcttccagga tttgttttca 2640 gaaacaagaa ttgagttgat ggtcctatgt gtcacattca tcacaggttt cataccaaca 2700 caggcttcag cacttccttt ggtgtgtttc ctgtcccagt gaagttggaa ccaaataatg 2760 tgtagtctct ataaccaata cctttgtttt catgtgtaag aaaaggccca ttacttttaa 2820 ggtatgtgct gtcctattga gcaaataact ttttttcaat tgccagctac tgcttttatt 2880 catcaaaata aaataacttg ttctgaaaaa aaa 2913 <210> 77 <211> 2379 <212> DNA <213> Homo sapiens <400> 77 ggaaaaaagc gacttgtggc ggtcgagcgt ggcgcaggcg aatcctcggc actaagcaaa 60 tatggacctc gcggcggcag cggagccggg cgccggcagc cagcacctgg aggtccgcga 120 cgaggtggcc gagaagtgcc agaaactgtt cctggacttc ttggaggagt ttcagagcag 180 cgatggagaa attaaatact tgcaattagc agaggaactg attcgtcctg agagaaacac 240 attggttgtg agttttgtgg acctggaaca atttaaccag caactttcca ccaccattca 300 agaggagttc tatagagttt acccttacct gtgtcgggcc ttgaaaacat tcgtcaaaga 360 ccgtaaagag atccctcttg ccaaggattt ttatgttgca ttccaagacc tgcctaccag 420 acacaagatt cgagagctca cctcatccag aattggtttg ctcactcgca tcagtgggca 480 ggtggtgcgg actcacccag ttcacccaga gcttgtgagc ggaacttttc tgtgcttgga 540 ctgtcagaca gtgatcaggg atgtagaaca gcagttcaaa tacacacagc caaacatctg 600 ccgaaatcca gtttgtgcca acaggaggag attcttactg gatacaaata aatcaagatt 660 tgttgatttt caaaaggttc gtattcaaga gacccaagct gagcttcctc gagggagtat 720 cccccgcagt ttagaagtaa ttttaagggc tgaagctgtg gaatcagctc aagctggtga 780 caagtgtgac tttacaggga cactgattgt tgtgcctgac gtctccaagc ttagcacacc 840 aggagcacgt gcagaaacta attcccgtgt cagtggtgtt gatggatatg agacagaagg 900 cattcgagga ctccgggccc ttggtgttag ggacctttct tataggctgg tctttcttgc 960 ctgctgtgtt gcgccaacca acccaaggtt tggggggaaa gagctcagag atgaggaaca 1020 gacagctgag agcattaaga accaaatgac tgtgaaagaa tgggagaaag tgtttgagat 1080 gagtcaagat aaaaatctat accacaatct ttgtaccagc ctgttcccta ctatacatgg 1140 caatgatgaa gtaaaacggg gtgtcctgct gatgctcttt ggtggcgttc caaagacaac 1200 aggagaaggg acctctcttc gaggggacat aaatgtttgc attgttggtg acccaagtac 1260 agctaagagc caatttctca agcacgtgga ggagttcagc cccagagctg tctacaccag 1320 tggtaaagcg tccagtgctg ctggcttaac agcagctgtt gtgagagatg aagaatctca 1380 tgagtttgtc attgaggctg gagctttgat gttggctgat aatggtgtgt gttgtattga 1440 tgaatttgat aagatggacg tgcgggatca agttgctatt catgaagcta tggaacagca 1500 gaccatatcc atcactaaag caggagtgaa ggctactctg aacgcccgga cgtccatttt 1560 ggcagcagca aacccaatca gtggacacta tgacagatca aaatcattga aacagaatat 1620 aaatttgtca gctcccatca tgtcccgatt cgatctcttc tttatccttg tggatgaatg 1680 taatgaggtt acagattatg ccattgccag gcgcatagta gatttgcatt caagaattga 1740 ggaatcaatt gatcgtgtct attccctcga tgatatcaga agatatcttc tctttgcaag 1800 acagtttaaa cccaagattt ccaaagagtc agaggacttc attgtggagc aatataaaca 1860 tctccgccag agagatggtt ctggagtgac caagtcttca tggaggatta cagtgcgaca 1920 gcttgagagc atgattcgtc tctctgaagc tatggctcgg atgcactgct gtgatgaggt 1980 ccaacctaaa catgtgaagg aagctttccg gttactgaat aaatcaatca tccgtgtgga 2040 aacacctgat gtcaatctag atcaagagga agagatccag atggaggtag atgagggtgc 2100 tggtggcatc aatggtcatg ctgacagccc tgctcctgtg aacgggatca atggctacaa 2160 tgaagacata aatcaagagt ctgctcccaa agcctcctta aggctgggct tctctgagta 2220 ctgccgaatc tctaacctta ttgtgcttca cctcagaaag gtggaagaag aagaggacga 2280 gtcagcatta aagaggagcg agcttgttaa ctggtacttg aaggaaatcg aatcagagat 2340 agactctgaa gaagaactta taaaaaaaaa aaaaaaaaa 2379 <210> 78 <211> 1437 <212> DNA <213> Homo sapiens <400> 78 ctcagcttcc ccaggagcaa gacctctgag cccgccaagc gcggccgcac ggccctcggc 60 agcgatggca ctgaaggact acgcgctaga gaaggaaaag gttaagaagt tcttacaaga 120 gttctaccag gatgatgaac tcgggaagaa gcagttcaag tatgggaacc agttggttcg 180 gctggctcat cgggaacagg tggctctgta tgtggacctg gacgacgtag ccgaggatga 240 ccccgagttg gtggactcaa tttgtgagaa tgccaggcgc tacgcgaagc tctttgctga 300 tgccgtacaa gagctgctgc ctcagtacaa ggagagggaa gtggtaaata aagatgtcct 360 ggacgtttac attgagcatc ggctaatgat ggagcagcgg agtcgggacc ctgggatggt 420 ccgaagcccc cagaaccagt accctgctga actcatgcgc agatttgagc tgtattttca 480 aggccctagc agcagcaagc ctcgtgtgat ccgggaagtg cgggctgact ctgtggggaa 540 gttggtaact gtgcgtggaa tcgtcactcg tgtctctgaa gtcaaaccca agatggtggt 600 ggccacttac acttgtgacc agtgtggggc agagacctac cagccgatcc agtctcccac 660 tttcatgcct ctgatcatgt gcccaagcca ggagtgccaa accaaccgct caggagggcg 720 gctgtatctg cagacacggg gctccagatt catcaaattc caggagatga agatgcaaga 780 acatagtgat caggtgcctg tgggaaatat ccctcgtagt atcacggtgc tggtagaagg 840 agagaacaca aggattgccc agcctggaga ccacgtcagc gtcactggta ttttcttgcc 900 aatcctgcgc actgggttcc gacaggtggt acagggttta ctctcagaaa cctacctgga 960 agcccatcgg attgtgaaga tgaacaagag tgaggatgat gagtctgggg ctggagagct 1020 caccagggag gagctgaggc aaattgcaga tgtgatattt gccaccgtcc gtgaactggt 1080 ctcagggggc cgaagtgtcc ggttctctga ggcagagcag cgctgtgtat ctcgtggctt 1140 cacacccgcc cagttccagg cggctctgga tgaatatgag gagctcaatg tctggcaggt 1200 caatgcttcc cggacacgga tcacttttgt ctgattccag cctgcttgca accctggggt 1260 cctcttgttc cctgctggcc tgccccttgg gaaggggcag tgatgccttt gaggggaagg 1320 aggagcccct ctttctccca tgctgcactt actccttttg ctaataaaag tgtttgtaga 1380 ttgtcaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa 1437 <210> 79 <211> 655 <212> DNA <213> Homo sapiens <400> 79 gggaacaggt ggctctgtat gtggacctgg acgacgtagc cgaggatgac cccgagttgg 60 tggactcaat ttgtgagaat gccagaccat ctccattgcc aaggccggca ttctcaccac 120 actcaatgcc cgctgctcca tcctggctgc cgccaaccct gcctacgggc gccacaaccc 180 tcgccgcagc ctggagcaga acatacagct acctgctgca ctgctctccc ggtttgacct 240 cctctggctg attcaggacc ggcccgaccg agacaatgac ctacggttgg cccagcacat 300 tacctatgtg caccagcaca gccggcagcc cccctcccag tttgaacctc tggacatgaa 360 gctcatgagg cgttacatag ccatgtgccg cgagaagcag cccatggtgc cagagtctct 420 ggctgactac atcacagcag catacgtgga gatgaggcga gaggcttggg ctagtaagga 480 tgccacctat acttctgccc ggaccctgct ggctattctg cgccttttca ctgctctggc 540 acgtctgaga atggtggatg tggtggaaaa agaagatgtg aatgaagcct tcagcttatg 600 gagatgcaaa ggacttcttt ttaagagaca aagggcagac aggcttggac tcaca 655 <210> 80 <211> 3704 <212> DNA <213> Homo sapiens <400> 80 ctttgagcgg aagttggatc actgaagcgc caaaaaagaa tttaggggaa gacctgattt 60 tcgcttgagg catttttgcg gcgctgtgcg ctacagacac cttctggaag ctgcggtggg 120 gaaactgagt ttcccgagcc gttgagacag atggggttca gcaccgcgcg gggacgacag 180 gaaagctgcg gctgaagaga actgcggact tggcaggagt cgcctgagga gctaagatcc 240 cggagactct tagccccgtg gtgcttctct acgggaggga gggagggaga atccggccgg 300 acagatctgc gcgtatcctg gagccggccc agttgtgaac taggagagct ttgggacctc 360 tgtcccaagc aagagagatg aatggagagt atagaggcag aggatttgga cgaggaagat 420 ttcaaagctg gaaaagggga agaggtggtg ggaacttctc aggaaaatgg agagaaagag 480 aacacagacc tgatctgagt aaaaccacag gaaaacgtac ttctgaacaa accccacagt 540 ttttgctttc aacaaagacc ccacagtcaa tgcagtcaac attggatcga ttcataccat 600 ataaaggctg gaagctttat ttctctgaag tttacagcga tagctctcct ttgattgaga 660 agattcaagc atttgaaaaa tttttcacaa ggcatattga tttgtatgac aaggatgaaa 720 tagaaagaaa gggaagtatt ttggtagatt ttaaagaact gacagaaggt ggtgaagtaa 780 ctaacttgat accagatata gcaactgaac taagagatgc acctgagaaa accttggctt 840 gcatgggttt ggcaatacat caggtgttaa ctaaggacct tgaaaggcat gcagctgagt 900 tacaagccca ggaaggattg tctaatgatg gagaaacaat ggtaaatgtg ccacatattc 960 atgcaagggt gtacaactat gagcctttga cacagctcaa gaatgtcaga gcaaattact 1020 atggaaaata cattgctcta agagggacag tggttcgtgt cagtaatata aagcctcttt 1080 gcaccaagat ggcttttctt tgtgctgcat gtggagaaat tcagagcttt cctcttccag 1140 atggaaaata cagtcttccc acaaagtgtc ctgtgcctgt gtgtcgaggc aggtcattta 1200 ctgctctccg cagctctcct ctcacagtta cgatggactg gcagtcaatc aaaatccagg 1260 aattgatgtc tgatgatcag agagaagcag gtcggattcc acgaacaata gaatgtgagc 1320 ttgttcatga tcttgtggat agctgtgtcc cgggagacac agtgactatt actggaattg 1380 tcaaagtctc aaatgcggaa gaaggttctc gaaataagaa tgacaagtgt atgttccttt 1440 tgtatattga agcaaattct attagtaata gcaaaggaca gaaaacaaag agttctgagg 1500 atgggtgtaa gcatggaatg ttgatggagt tctcacttaa agacctttat gccatccaag 1560 agattcaagc tgaagaaaac ctgtttaaac tcattgtcaa ctcgctttgc cctgtcattt 1620 ttggtcatga acttgttaaa gcaggtttgg cattagcact ctttggagga agccagaaat 1680 acgcagatga caaaaacaga attccaattc ggggagaccc ccacatcctt gttgttggag 1740 atccaggcct aggaaaaagt caaatgctac aggcagcgtg caatgttgcc ccacgtggcg 1800 tgtatgtttg tggtaacacc acgaccacct ctggtctgac ggtaactctt tcaaaagata 1860 gttcctctgg agattttgct ttggaagctg gtgccctggt acttggtgat caaggtattt 1920 gtggaatcga tgaatttgat aagatgggga atcaacatca agccttgttg gaagccatgg 1980 agcagcaaag tattagtctt gctaaggctg gtgtggtttg tagccttcct gcaagaactt 2040 ccattattgc tgctgcaaat ccagttggag gacattacaa taaagccaaa acagtttctg 2100 agaatttaaa aatggggagt gcactactat ccagatttga tttggtcttt atcctgttag 2160 atactccaaa tgagcatcat gatcacttac tctctgaaca tgtgattgca ataagagctg 2220 gaaagcagag aaccattagc agtgccacag tagctcgtat gaatagtcaa gattcaaata 2280 cttccgtact tgaagtagtt tctgagaagc cattatcaga aagactaaag gtggttcctg 2340 gagaaacaat agatcccatt ccccaccagc tattgagaaa gtacattggc tatgctcggc 2400 agtatgtgta cccaaggcta tccacagaag ctgctcgagt tcttcaagat ttttaccttg 2460 agctccggaa acagagccag aggttaaata gctcaccaat cactaccagg cagctggaat 2520 ctttgattcg tctgacagag gcacgagcaa ggttggaatt gagagaggaa gcaaccaaag 2580 aagacgctga ggatatagtg gaaattatga aatatagcat gctaggaact tactctgatg 2640 aatttgggaa cctagatttt gagcgatccc agcatggttc tggaatgagc aacaggtcaa 2700 cagcgaaaag atttatttct gctctcaaca acgttgctga aagaacttat aataatatat 2760 ttcaatttca tcaacttcgg cagattgcca aagaactaaa cattcaggtt gctgattttg 2820 aaaattttat tggatcacta aatgaccagg gttacctctt gaaaaaaggc ccaaaagttt 2880 accagcttca aactatgtaa aaggacttca ccaagttagg gcctcctggg tttattgcag 2940 attaaagcca tctcagtgaa gatatgcgtg cacgcacaga cagacagaca cacacacaca 3000 cacacacaca cacacacaca cacacacaca cagtcaaata ctgttctctg aaaaatgatg 3060 tcccaaaagt attataatag gaaaaaagca ttaaatataa taaactaatt taagaagtga 3120 taaagtctcc agatgcagta gctcacactg taatcacagt gactcaggag gctgaggtga 3180 gaggattcct tgaggccagg gttcgagacc aaccttgggc aacatagcaa gaccccattt 3240 cttaaaaaaa aaaaaaaaaa atttaaactt agctgggtat ggtggcacat gcctatagtc 3300 tcagctactt gtgaggctga ggcaggagga ttctttgagc ccaggagttt gaggttacag 3360 tgagccacaa tcacaccaat cactgcactc cagcctgggc aataaagtaa ctcttgactc 3420 aaaaaaataa aaaaaattgt agtggtagcc atgtgttaat tgttaaataa attctccaaa 3480 gggctaaaag taaattactt ataaattttt tatagttgta tttttgacct gccttttata 3540 tgtatgaata tttcatagtt ttgcatatca gatgtaggca tacagacaaa tacataaacc 3600 aatgaatata ttacatattc tgtgttccaa taaaacttta tttatggaca ctaaaatttg 3660 aatttcataa aattttccca tgtcaagaat acaaaaaaaa aaaa 3704 <210> 81 <211> 3254 <212> DNA <213> Homo sapiens <220> <221> misc_feature <222> (2907)..(2907) <223> "n" means any of A, T, G, and C. <400> 81 ctttgagcgg aagttggatc actgaagcgc caaaaaagaa tttaggggaa gacctgattt 60 tcgcttgagg catttttgcg gcgctgtgcg ctacagacac cttctggaag ctgcggtggg 120 gaaactgagt ttcccgagcc gttgagacag atggggttca gcaccgcgcg gggacgacag 180 gaaagctgcg gctgaagaga actgcggact tggcaggagt cgcctgagga gctaagatcc 240 cggagactct tagccccgtg gtgcttctct acgggagcgg gggagggaga atccggccgg 300 acagatctgc gcgtatcctg gagccggccc agttgtgaac taggagagct ttgggacctc 360 tgtcccaagc aagagagatg aatggagagt atagaggcag aggatttgga cgaggaagat 420 ttcaaagctg gaaaagggga agaggtggtg ggaacttctc aggaaaatgg agagaaagag 480 aacacagacc tgatctgagt aaaaccacag gaaaacgtac ttctgaacaa accccacagt 540 ttttgctttc aacaaagacc ccacagtcaa tgcagtcaac attggatcga ttcataccat 600 ataaaggctg gaagctttat ttctctgaag tttacagcga tagctctcct ttgattgaga 660 agattcaagc atttgaaaaa tttttcacaa ggcatattga tttgtatgac aaggatgaaa 720 tagaaagaaa gggaagtatt ttggtagatt ttaaagaact gacagaaggt ggtgaagtaa 780 ctaacttgat accagatata gcaactgaac taagagatgc acctgagaaa accttggctt 840 gcatgggttt ggcaatacat caggtgttaa ctaaggacct tgaaaggcat gcagctgagt 900 tacaagccca ggaaggattg tctaatgatg gagaaacaat ggtaaatgtg ccacatattc 960 atgcaagggt gtacaactat gagcctttga cacagctcaa gaatgtccga gcaaattact 1020 atggaaaata cattgctcta agagggacag tggttcgtgt cagtaatata aagcctcttt 1080 gcaccaagat ggcttttctt tgtgctgcat gtggagaaat tcagagcttt cctcttccag 1140 atggaaaata cagtcttccc acaaagtgtc ctgtgcctgt gtgtcgaggc aggtcattta 1200 ctgctctccg cagctctcct ctcacagtta cgatggactg gcagtcaatc aaaatccagg 1260 aattgatgtc tgatgatcag agagaagcag gtcggattcc acgaacaata gaatgtgagc 1320 ttgttcatga tcttgtggat agctgtgtcc cgggagacac agtgactatt actggaattg 1380 tcaaagtctc aaatgcggaa gaaggttctc gaaataagaa tgacaagtgt atgttccttt 1440 tgtatattga agcaaattct attagtaata gcaaaggaca gaaaacaaag agttctgagg 1500 atgggtgtaa gcatggaatg ttgatggagt tctcacttaa agacctttat gccatccaag 1560 agattcaagc tgaagaaaac ctgtttaaac tcattgtcaa ctcgctttgc cctgtcattt 1620 ttggtcatga acttgttaaa gcaggtttgg cattagcact ctttggagga agccagaaat 1680 acgcagatga caaaaacaga attccaattc ggggagaccc ccacatcctt gttgttggag 1740 atccaggcct aggaaaaagt cagatgctac aggcagcgtg caatgttgcc ccacgtggcg 1800 tgtatgtttg tggtaacacc acgaccacct ctggtctgac ggtaactctt tcaaaagata 1860 gttcctctgg agattttgct ttggaagctg gtgccctggt acttggtgat caaggtattt 1920 gtggaatcga tgaatttgat aagatgggga atcaacatca agccttgttg gaagccatgg 1980 agcagcaaag tattagtctt gctaaggctg gtgtggtttg tagccttcct gcaagaactt 2040 ccattattgc tgctgcaaat ccagttggag gacattacaa taaagccaaa acagtttctg 2100 agaatttaaa aatggggagt gcactactat ccagatttga tttggtcttt atcctgttag 2160 atactccaaa tgagcatcat gatcacttac tctctgaaca tgtgattgca ataagagctg 2220 gaaagcagag aaccattagc agtgccacag tagctcgtat gaatagtcaa gattcaaata 2280 cttccgtact tgaagtagtt tctgagaagc cattatcaga aagactaaag gtggttcctg 2340 gagaaacaat agatcccatt ccccaccagc tattgagaaa gtacattggc tatgctcggc 2400 agtatgtgta cccaaggcta tccacagaag ctgctcgagt tcttcaagat ttttaccttg 2460 agctccggaa acagagccag aggttaaata gctcaccaat cactaccagg cagctggaat 2520 ctttgattcg tctgacagag gcacgagcaa ggttggaatt gagagaggaa gcaaccaaag 2580 aagacgctga ggatatagtg gaaattatga aatatagcat gctaggaact tactctgatg 2640 aatttgggaa cctagatttt gagcgatccc agcatggttc tggaatgagc aacaggtcaa 2700 cagcgaaaag atttatttct gctctcaaca acgttgctga aagaacttat aataatatat 2760 ttcaatttca tcaacttcgg cagattgcca aagaactaaa cattcaggtt gctgattttg 2820 aaaattttat tggatcacta aatgaccagg gttacctctt gaaaaaaggc ccaaaagttt 2880 accagcttca aactatgtaa aaggacnttc accaagttag ggcctcctgg gtttattgca 2940 gattaaagcc atctcagtga agatatgcgt gcacgcacag acagacagac acacacacac 3000 acacacacac acacacacac acacacacac agtcaaatac tgttctctga aaaatgatgt 3060 cccaaaagta ttataatagg aaaaaagcat taaatataat aaactaattt aagaagtgat 3120 aaagtctcca gatgcagtag ctcacactgt aatcacagtg actcaggagg ctgaggtgag 3180 aggattcctt gaggccaggg ttcgagacca accttgggca acatagcaag accccatttc 3240 ttaaaaaaaa aaaa 3254 <210> 82 <211> 2585 <212> DNA <213> Homo sapiens <400> 82 ggcacgaggg gcatattgat ttgtatgaca aggatgaaat agaaagaaag ggaagtattt 60 tggtagattt taaagaactg acagaaggtg gtgaagtaac taacttgata ccagatatag 120 caactgaact aagagatgca cctgagaaaa ccttggcttg catgggtttg gcaatacatc 180 aggtgttaac taaggacctt gaaaggcatg cagctgagtt acaagcccag gaaggattgt 240 ctaatgatgg agaaacaatg gtaaatgtgc cacatattca tgcaagggtg tacaactatg 300 agcctttgac acagctcaag aatgtcagag caaattacta tggaaaatac attgctctaa 360 gagggacagt ggttcgtgtc agtaatataa agcctctttg caccaagatg gcttttcttt 420 gtgctgcatg tggagaaatt cagagctttc ctcttccaga tggaaaatac agtcttccca 480 caaagtgtcc tgtgcctgtg tgtcgaggca ggtcatttac tgctctccgc agctctcctc 540 tcacagttac gatggactgg cagtcaatca aaatccagga attgatgtct gatgatcaga 600 gagaagcagg tcggattcca cgaacaatag aatgtgagct tgttcatgat cttgtggata 660 gctgtgtccc gggagacaca gtgactatta ctggaattgt caaagtctca aatgcggaag 720 aaggttctcg aaataagaat gacaagtgta tgttcctttt gtatattgaa gcaaattcta 780 ttagtaatag caaaggacag aaaacaaaga gttctgagga tgggtgtaag catggaatgt 840 tgatggagtt ctcacttaaa gacctttatg ccatccaaga gattcaagct gaagaaaacc 900 tgtttaaact cattgtcaac tcgctttgcc ctgtcatttt tggtcatgaa cttgttaaag 960 caggtttggc attagcactc tttggaggaa gccagaaata cgcagatgac aaaaacagaa 1020 ttccaattcg gggagacccc cacatccttg ttgttggaga tccaggccta ggaaaaagtc 1080 aaatgctaca ggcagcgtgc aatgttgccc cacgtggcgt gtatgtttgt ggtaacacca 1140 cgaccacctc tggtctgacg gtaactcttt caaaagatag ttcctctgga gattttgctt 1200 tggaagctgg tgccctggta cttggtgatc aaggtatttg tggaatcgat gaatttgata 1260 agatggggaa tcaacatcaa gccttgttgg aagccatgga gcagcaaagt attagtcttg 1320 ctaaggctgg tgtggtttgt agccttcctg caagaacttc cattattgct gctgcaaatc 1380 cagttggagg acattacaat aaagccaaaa cagtttctga gaatttaaaa atggggagtg 1440 cactactatc cagatttgat ttggtcttta tcctgttaga tactccaaat gagcatcatg 1500 atcacttact ctctgaacat gtgattgcaa taagagctgg aaagcagaga accattagca 1560 gtgccacagt agctcgtatg aatagtcaag attcaaatac ttccgtactt gaagtagttt 1620 ctgagaagcc attatcagaa agactaaagg tggttcctgg agaaacaata gatcccattc 1680 cccaccagct attgagaaag tacattggct atgctcggca gtatgtgtac ccaaggctat 1740 ccacagaagc tgctcgagtt cttcaagatt tttaccttga gctccggaaa cagagccaga 1800 ggttaaatag ctcaccaatc actaccaggc agctggaatc tttgattcgt ctgacagagg 1860 cacgagcaag gttggaattg agagaggaag caaccaaaga agacgctgag gatatagtgg 1920 aaattatgaa atatagcatg ctaggaactt actctgatga atttgggaac ctagattttg 1980 agcgatccca gcatggttct ggaatgagca acaggtcaac agcgaaaaga tttatttctg 2040 ctctcaacaa cgttgctgaa agaacttata ataatatatt tcaatttcat caacttcggc 2100 agattgccaa agaactaaac attcaggttg ctgattttga aaattttatt ggatcactaa 2160 atgaccaggg ttacctcttg aaaaaaggcc caaaagttta ccagcttcaa actatgtaaa 2220 aggacttcac caagttaggg cctcctgggt ttattgcaga ttaaagccat ctcagtgaag 2280 atatgcgtgc acgcacagac agacagacac acacacacac acacacacac acacacacac 2340 acacacacag tcaaatactg ttctctgaaa aatgatgtcc caaaagtatt ataataggaa 2400 aaaagcatta aatataataa actaatttaa gaagtgataa agtctccaga tgcagtagct 2460 cacactgtaa tcacagtgac tcaggaggct gaggtgagag gattccttga ggccagggtt 2520 cgagaccaac cttgggcaac atagcaagac cccatttctt aaaaaaaaaa aaaaaaaaaa 2580 aaaaa 2585 <210> 83 <211> 2284 <212> DNA <213> Homo sapiens <400> 83 tgcaagggtg tacaactatg agcctttgac acagctcaag aatgtcagag caaattacta 60 tggaaaatac attgctctaa gagggacagt ggttcgtgtc agtaatataa agcctctttg 120 caccaagatg gcttttcttt gtgctgcatg tggagaaatt cagagctttc ctcttccaga 180 tggaaaatac agtcttccca caaagtgtcc tgtgcctgtg tgtcgaggca ggtcatttac 240 tgctctccgc agctctcctc tcacagttac gatggactgg cagtcaatca aaatccagga 300 attgatgtct gatgatcaga gagaagcagg tcggattcca cgaacaatag aatgtgagct 360 tgttcatgat cttgtggata gctgtgtccc gggagacaca gtgactatta ctggaattgt 420 caaagtctca aatgcggaag aaggttctcg aaataagaat gacaagtgta tgttcctttt 480 gtatattgaa gcaaattcta ttagtaatag caaaggacag aaaacaaaga gttctgagga 540 tgggtgtaag catggaatgt tgatggagtt ctcacttaaa gacctttatg ccatccaaga 600 gattcaagct gaagaaaacc tgtttaaact cattgtcaac tcgctttgcc ctgtcatttt 660 tggtcacgaa cttgttaaag caggtttggc attagcactc tttggaggaa gccagaaata 720 cgcagatgac aaaaacagaa ttccaattcg gggagacccc cacatccttg ttgttggaga 780 tccaggccta ggaaaaagtc aaatgctaca ggcagcgtgc aatgttgccc cacgtggcgt 840 gtatgtttgt ggtaacacca cgaccacctc tggtctgacg gtaactcttt caaaagatag 900 ttcctctgga gattttgctt tggaagctgg tgccctggta cttggtgatc aaggtatttg 960 tggaatcgat gaatttgata agatggggaa tcaacatcaa gccttgttgg aagccatgga 1020 gcagcaaagt attagtcttg ctaaggctgg tgtggtttgt agccttcctg caagaacttc 1080 cattattgct gctgcaaatc cagttggagg acattacaat aaagccaaaa cagtttctga 1140 gaatttaaaa atggggagtg cactactatc cagatttgat ttggtcttta tcctgttaga 1200 tactccaaat gagcatcatg atcacttact ctctgaacat gtgattgcaa taagagctgg 1260 aaagcagaga accattagca gtgccacagt agctcgtatg aatagtcaag attcaaatac 1320 ttccgtactt gaagtagttt ctgagaagcc attatcagaa agactaaagg tggttcctgg 1380 agaaacaata gatcccattc cccaccagct attgagaaag tacattggct atgctcggca 1440 gtatgtgtac ccaaggctat ccacagaagc tgctcgagtt cttcaagatt tttaccttga 1500 gctccggaaa cagagccaga ggttaaatag ctcaccaatc actaccaggc agctggaatc 1560 tttgattcgt ctgacagagg cacgagcaag gttggaattg agagaggaag caaccaaaga 1620 agacgctgag gatatagtgg aaattatgaa atatagcatg ctaggaactt actctgatga 1680 atttgggaac ctagattttg agcgatccca gcatggttct ggaatgagca acaggtcaac 1740 agcgaaaaga tttatttctg ctctcaacaa cgttgctgaa agaacttata ataatatatt 1800 tcaatttcat caacttcggc agattgccaa agaactaaac attcaggttg ctgattttga 1860 aaattttatt ggatcactaa atgaccaggg ttacctcttg aaaaaaggcc caaaagttta 1920 ccagcttcaa actatgtaaa aggacttcac caagttaggg cctcctgggt ttattgcaga 1980 ttaaagccat ctcagtgaag atatgcgtgc acgcacagac agacagacac acacacacac 2040 acacacacac acacacacac acacacacac acagtcaaat actgttctct gaaaaatgat 2100 gtcccaaaag tattataata ggaaaaaagc attaaatata ataaactaat ttaagaagtg 2160 ataaagtctc cagatgcagt agctcacact gtaatcacag tgactcagga ggctgaggtg 2220 agaggattcc ttgaggccag ggttcgagac caaccttggg caacatagca agaccccatt 2280 tctt 2284 <210> 84 <211> 3710 <212> DNA <213> Homo sapiens <400> 84 ctttgagcgg aagttggatc actgaagcgc caaaaaagaa tttaggggaa gacctgattt 60 tcgcttgagg catttttgcg gcgctgtgcg ctacagacac cttctggaag ctgcggtggg 120 gaaactgagt ttcccgagcc gttgagacag atggggttca gcaccgcgcg gggacgacag 180 gaaagctgcg gctgaagaga actgcggact tggcaggagt cgcctgagga gctaagatcc 240 cggagactct tagccccgtg gtgcttctct acgggaggga gggagggaga atccggccgg 300 acagatctgc gcgtatcctg gagccggccc agttgtgaac taggagagct ttgggacctc 360 tgtcccaagc aagtaagaac tttagcctta ggagatgtaa ataaagtagt atttgaagaa 420 gcacaggaga gatgaatgga gagtatagag gcagaggatt tggacgagga agatttcaaa 480 gctggaaaag gggaagaggt ggtgggaact tctcaggaaa atggagagaa agagaacaca 540 gacctgatct gagtaaaacc acaggaaaac gtacttctga acaaacccca cagtttttgc 600 tttcaacaaa gaccccacag tcaatgcagt caacattgga tcgattcata ccatataaag 660 gctggaagct ttatttctct gaagtttaca gcgatagctc tcctttgatt gagaagattc 720 aagcatttga aaaatttttc acaaggcata ttgatttgta tgacaaggat gaaatagaaa 780 gaaagggaag tattttggta gattttaaag aactgacaga aggtggtgaa gtaactaact 840 tgataccaga tatagcaact gaactaagag atgcacctga gaaaaccttg gcttgcatgg 900 gtttggcaat acatcaggtg ttaactaagg accttgaaag gcatgcagct gagttacaag 960 cccaggaagg attgtctaat gatggagaaa caatggtaaa tgtgccacat attcatgcaa 1020 gggtgtacaa ctatgagcct ttgacacagc tcaagaatgt cagagcaaat tactatggaa 1080 aatacattgc tctaagaggg acagtggttc gtgtcagtaa tataaagcct ctttgcacca 1140 agatggcttt tctttgtgct gcatgtggag aaattcagag ctttcctctt ccagatggaa 1200 aatacagtct tcccacaaag tgtcctgtgc ctgtgtgtcg aggcaggtca tttactgctc 1260 tccgcagctc tcctctcaca gttacgatgg actggcagtc aatcaaaatc caggaattga 1320 tgtctgatga tcagagagaa gcaggtcgga ttccacgaac aatagaatgt gagcttgttc 1380 atgatcttgt ggatagctgt gtcccgggag acacagtgac tattactgga attgtcaaag 1440 tctcaaatgc ggaagaagca aattctatta gtaatagcaa aggacagaaa acaaagagtt 1500 ctgaggatgg gtgtaagcat ggaatgttga tggagttctc acttaaagac ctttatgcca 1560 tccaagagat tcaagctgaa gaaaacctgt ttaaactcat tgtcaactcg ctttgccctg 1620 tcatttttgg tcatgaactt gttaaagcag gtttggcatt agcactcttt ggaggaagcc 1680 agaaatacgc agatgacaaa aacagaattc caattcgggg agacccccac atccttgttg 1740 ttggagatcc aggcctagga aaaagtcaaa tgctacaggc agcgtgcaat gttgccccac 1800 gtggcgtgta tgtttgtggt aacaccacga ccacctctgg tctgacggta actctttcaa 1860 aagatagttc ctctggagat tttgctttgg aagctggtgc cctggtactt ggtgatcaag 1920 gtatttgtgg aatcgatgaa tttgataaga tggggaatca acatcaagcc ttgttggaag 1980 ccatggagca gcaaagtatt agtcttgcta aggctggtgt ggtttgtagc cttcctgcaa 2040 gaacttccat tattgctgct gcaaatccag ttggaggaca ttacaataaa gccaaaacag 2100 tttctgagaa tttaaaaatg gggagtgcac tactatccag atttgatttg gtctttatcc 2160 tgttagatac tccaaatgag catcatgatc acttactctc tgaacatgtg attgcaataa 2220 gagctggaaa gcagagaacc attagcagtg ccacagtagc tcgtatgaat agtcaagatt 2280 caaatacttc cgtacttgaa gtagtttctg agaagccatt atcagaaaga ctaaaggtgg 2340 ttcctggaga aacaatagat cccattcccc accagctatt gagaaagtac attggctatg 2400 ctcggcagta tgtgtaccca aggctatcca cagaagctgc tcgagttctt caagattttt 2460 accttgagct ccggaaacag agccagaggt taaatagctc accaatcact accaggcagc 2520 tggaatcttt gattcgtctg acagaggcac gagcaaggtt ggaattgaga gaggaagcaa 2580 ccaaagaaga cgctgaggat atagtggaaa ttatgaaata tagcatgcta ggaacttact 2640 ctgatgaatt tgggaaccta gattttgagc gatcccagca tggttctgga atgagcaaca 2700 ggtcaacagc gaaaagattt atttctgctc tcaacaacgt tgctgaaaga acttataata 2760 atatatttca atttcatcaa cttcggcaga ttgccaaaga actaaacatt caggttgctg 2820 attttgaaaa ttttattgga tcactaaatg accagggtta cctcttgaaa aaaggcccaa 2880 aagtttacca gcttcaaact atgtaaaagg acttcaccaa gttagggcct cctgggttta 2940 ttgcagatta aagccatctc agtgaagata tgcgtgcacg cacagacaga cagacacaca 3000 cacacacaca cacacacaca cacacacaca cacacacagt caaatactgt tctctgaaaa 3060 atgatgtccc aaaagtatta taataggaaa aaagcattaa atataataaa ctaatttaag 3120 aagtgataaa gtctccagat gcagtagctc acactgtaat cacagtgact caggaggctg 3180 aggtgagagg attccttgag gccagggttc gagaccaacc ttgggcaaca tagcaagacc 3240 ccatttctta aaaaaaaaaa aaaaaaattt aaacttagct gggtatggtg gcacatgcct 3300 atagtctcag ctacttgtga ggctgaggca ggaggattct ttgagcccag gagtttgagg 3360 ttacagtgag ccacaatcac accaatcact gcactccagc ctgggcaata aagtaactct 3420 tgactcaaaa aaataaaaaa aattgtagtg gtagccatgt gttaattgtt aaataaattc 3480 tccaaagggc taaaagtaaa ttacttataa attttttata gttgtatttt tgacctgcct 3540 tttatatgta tgaatatttc atagttttgc atatcagatg taggcataca gacaaataca 3600 taaaccaatg aatatattac atattctgtg ttccaataaa actttattta tggacactaa 3660 aatttgaatt tcataaaatt ttcccatgtc aagaatacaa aaaaaaaaaa 3710 <210> 85 <211> 2974 <212> DNA <213> Homo sapiens <400> 85 cagatctgcg cgtatcctgg agccggccca gttgtgaact aggagagctt tgggacctct 60 gtcccaagca agtaagaact ttagccttag gagatgtaaa taaagtagta tttgaagaag 120 cacaggagag atgaatggag agtatagagg cagaggattt ggacgaggaa gatttcaaag 180 ctggaaaagg ggaagaggtg gtgggaactt ctcaggaaaa tggagagaaa gagaacacag 240 acctgatctg agtaaaacca caggaaaacg tacttctgaa caaaccccac agtttttgct 300 ttcaacaaag accccacagt caatgcagtc aacattggat cgattcatac catataaagg 360 ctggaagctt tatttctctg aagtttacag cgatagctct cctttgattg agaagattca 420 agcatttgaa aaatttttca caaggcatat tgatttgtat gacaaggatg aaatagaaag 480 aaagggaagt attttggtag attttaaaga actgacagaa ggtggtgaag taactaactt 540 gataccagat atagcaactg aactaagaga tgcacctgag aaaaccttgg cttgcatggg 600 tttggcaata catcaggtgt taactaagga ccttgaaagg catgcagctg agttacaagc 660 ccaggaagga ttgtctaatg atggagaaac aatggtaaat gtgccacata ttcatgcaag 720 ggtgtacaac tatgagcctt tgacacagct caagaatgtc agagcaaatt actatggaaa 780 atacattgct ctaagaggga cagtggttcg tgtcagtaat ataaagcctc tttgcaccaa 840 gatggctttt ctttgtgctg catgtggaga aattcagagc tttcctcttc cagatggaaa 900 atacagtctt cccacaaagt gtcctgtgcc tgtgtgtcga ggcaggtcat ttactgctct 960 ccgcagctct cctctcacag ttacgatgga ctggcagtca atcaaaatcc aggaattgat 1020 gtctgatgat cagagagaag caggtcggat tccacgaaca atagaatgtg agcttgttca 1080 tgatcttgtg gatagctgtg tcccgggaga cacagtgact attactggaa ttgtcaaagt 1140 ctcaaatgcg gaagaagcaa attctattag taatagcaaa ggacagaaaa caaagagttc 1200 tgaggatggg tgtaagcatg gaatgttgat ggagttctca cttaaagacc tttatgccat 1260 ccaagagatt caagctgaag aaaacctgtt taaactcatt gtcaactcgc tttgccctgt 1320 catttttggt catgaacttg ttaaagcagg tttggcatta gcactctttg gaggaagcca 1380 gaaatacgca gatgacaaaa acagaattcc aattcgggga gacccccaca tccttgttgt 1440 tggagatcca ggcctaggaa aaagtcaaat gctacaggca gcgtgcaatg ttgccccacg 1500 tggcgtgtat gtttgtggta acaccacgac cacctctggt ctgacggtaa ctctttcaaa 1560 agatagttcc tctggagatt ttgctttgga agctggtgcc ctggtacttg gtgatcaagg 1620 tatttgtgga atcgatgaat ttgataagat ggggaatcaa catcaagcct tgttggaagc 1680 catggagcag caaagtatta gtcttgctaa ggctggtgtg gtttgtagcc ttcctgcaag 1740 aacttccatt attgctgctg caaatccagt tggaggacat tacaataaag ccaaaacagt 1800 ttctgagaat ttaaaaatgg ggagtgcact actatccaga tttgatttgg tctttatcct 1860 gttagatact ccaaatgagc atcatgatca cttactctct gaacatgtga ttgcaataag 1920 agctggaaag cagagaacca ttagcagtgc cacagtagct cgtatgaata gtcaagattc 1980 aaatacttcc gtacttgaag tagtttctga gaagccatta tcagaaagac taaaggtggt 2040 tcctggagaa acaatagatc ccattcccca ccagctattg agaaagtaca ttggctatgc 2100 tcggcagtat gtgtacccaa ggctatccac agaagctgct cgagttcttc aagattttta 2160 ccttgagctc cggaaacaga gccagaggtt aaatagctca ccaatcacta ccaggcagct 2220 ggaatctttg attcgtctga cagaggcacg agcaaggttg gaattgagag aggaagcaac 2280 caaagaagac gctgaggata tagtggaaat tatgaaatat agcatgctag gaacttactc 2340 tgatgaattt gggaacctag attttgagcg atcccagcat ggttctggaa tgagcaacag 2400 gtcaacagcg aaaagattta tttctgctct caacaacgtt gctgaaagaa cttataataa 2460 tatatttcaa tttcatcaac ttcggcagat tgccaaagaa ctaaacattc aggttgctga 2520 ttttgaaaat tttattggat cactaaatga ccagggttac ctcttgaaaa aaggcccaaa 2580 agtttaccag cttcaaacta tgtaaaagga cttcaccaag ttagggcctc ctgggtttat 2640 tgcagattaa agccatctca gtgaagatat gcgtgcacgc acagacagac agacacacac 2700 acacacacac acacacacac acacacacac acacacacag tcaaatactg ttctctgaaa 2760 aatgatgtcc caaaagtatt ataataggaa aaaagcatta aatataataa actaatttaa 2820 gaaggtgata aagtctccag atgcaggtag gctcacactg taatcacagt gactcaggag 2880 gctgaggtga gaggattcct tgaggccagg gttcgagacc aaccttgggc aacatagcaa 2940 gaccccattt cttaaaaaaa aaaaaaaaaa aaaa 2974 <210> 86 <211> 2971 <212> DNA <213> Homo sapiens <400> 86 cagatctgcg cgtatcctgg agccggccca gttgtgaact aggagagctt tgggacctct 60 gtcccaagca agtaagaact ttagccttag gagatgtaaa taaagtagta tttgaagaag 120 cacaggagag atgaatggag agtatagagg cagaggattt ggacgaggaa gatttcaaag 180 ctggaaaagg ggaagaggtg gtgggaactt ctcaggaaaa tggagagaaa gagaacacag 240 acctgatctg agtaaaacca caggaaaacg tacttctgaa caaaccccac agtttttgct 300 ttcaacaaag accccacagt caatgcagtc aacattggat cgattcatac catataaagg 360 ctggaagctt tatttctctg aagtttacag cgatagctct cctttgattg agaagattca 420 agcatttgaa aaatttttca caaggcatat tgatttgtat gacaaggatg aaatagaaag 480 aaagggaagt attttggtag attttaaaga actgacagaa ggtggtgaag taactaactt 540 gataccagat atagcaactg aactaagaga tgcacctgag aaaaccttgg cttgcatggg 600 tttggcaata catcaggtgt taactaagga ccttgaaagg catgcagctg agttacaagc 660 ccaggaagga ttgtctaatg atggagaaac aatggtaaat gtgccacata ttcatgcaag 720 ggtgtacaac tatgagcctt tgacacagct caagaatgtc agagcaaatt actatggaaa 780 atacattgct ctaagaggga cagtggttcg tgtcagtaat ataaagcctc tttgcaccaa 840 gatggctttt ctttgtgctg catgtggaga aattcagagc tttcctcttc cagatggaaa 900 atacagtctt cccacaaagt gtcctgtgcc tgtgtgtcga ggcaggtcat ttactgctct 960 ccgcagctct cctctcacag ttacgatgga ctggcagtca atcaaaatcc aggaattgat 1020 gtctgatgat cagagagaag caggtcggat tccacgaaca atagaatgtg agcttgttca 1080 tgatcttgtg gatagctgtg tcccgggaga cacagtgact attactggaa ttgtcaaagt 1140 ctcaaatgcg gaagaagcaa attctattag taatagcaaa ggacagaaaa caaagagttc 1200 tgaggatggg tgtaagcatg gaatgttgat ggagttctca cttaaagacc tttatgccat 1260 ccaagagatt caagctgaag aaaacctgtt taaactcatt gtcaactcgc tttgccctgt 1320 catttttggt catgaacttg ttaaagcagg tttggcatta gcactctttg gaggaagcca 1380 gaaatacgca gatgacaaaa acagaattcc aattcgggga gacccccaca tccttgttgt 1440 tggagatcca ggcctaggaa aaagtcaaat gctacaggca gcgtgcaatg ttgccccacg 1500 tggcgtgtat gtttgtggta acaccacgac cacctctggt ctgacggtaa ctctttcaaa 1560 agatagttcc tctggagatt ttgctttgga agctggtgcc ctggtacttg gtgatcaagg 1620 tatttgtgga atcgatgaat ttgataagat ggggaatcaa catcaagcct tgttggaagc 1680 catggagcag caaagtatta gtcttgctaa ggctggtgtg gtttgtagcc ttcctgcaag 1740 aacttccatt attgctgctg caaatccagt tggaggacat tacaataaag ccaaaacagt 1800 ttctgagaat ttaaaaatgg ggagtgcact actatccaga tttgatttgg tctttatcct 1860 gttagatact ccaaatgagc atcatgatca cttactctct gaacatgtga ttgcaataag 1920 agctggaaag cagagaacca ttagcagtgc cacagtagct cgtatgaata gtcaagattc 1980 aaatacttcc gtacttgaag tagtttctga gaagccatta tcagaaagac taaaggtggt 2040 tcctggagaa acaatagatc ccattcccca ccagctattg agaaagtaca ttggctatgc 2100 tcggcagtat gtgtacccaa ggctatccac agaagctgct cgagttcttc aagattttta 2160 ccttgagctc cggaaacaga gccagaggtt aaatagctca ccaatcacta ccaggcagct 2220 ggaatctttg attcgtctga cagaggcacg agcaaggttg gaattgagag aggaagcaac 2280 caaagaagac gctgaggata tagtggaaat tatgaaatat agcatgctag gaacttactc 2340 tgatgaattt gggaacctag attttgagcg atcccagcat ggttctggaa tgagcaacag 2400 gtcaacagcg aaaagattta tttctgctct caacaacgtt gctgaaagaa cttataataa 2460 tatatttcaa tttcatcaac ttcggcagat tgccaaagaa ctaaacattc aggttgctga 2520 ttttgaaaat tttattggat cactaaatga ccagggttac ctcttgaaaa aaggcccaaa 2580 agtttaccag cttcaaacta tgtaaaagga cttcaccaag ttagggcctc ctgggtttat 2640 tgcagattaa agccatctca gtgaagatat gcgtgcacgc acagacagac agacacacac 2700 acacacacac acacacacac acacacacac acacacacag tcaaatactg ttctctgaaa 2760 aatgatgtcc caaaagtatt ataataggaa aaaagcatta aatataataa actaatttaa 2820 gaagtgataa agtctccaga tgcagtagct cacactgtaa tcacagtgac tcaggaggct 2880 gaggtgagag gattccttga ggccagggtt cgagaccaac cttgggcaac atagcaagac 2940 cccatttctt aaaaaaaaaa aaaaaaaaaa a 2971 <210> 87 <211> 3178 <212> DNA <213> Homo sapiens <400> 87 gatctcttgg agacggcgac ccaggcatct ggggagccac agaagtcgta ctcccttaaa 60 ccctgctttg ctccccctgt ggatgtaacc ccttagctgg cattttgcat ctcaattggc 120 ttgtgatgga ggcgtctttg gggattcaga tggatgagcc aatggctttt tctccccagc 180 gtgaccggtt tcaggctgaa ggctctttaa aaaaaaacga gcagaatttt aaacttgcag 240 gtgttaaaaa agatattgag aagctttatg aagctgtacc acagcttagt aatgtgttta 300 agattgagga caaaattgga gaaggcactt tcagctctgt ttatttggcc acagcacagt 360 tacaagtagg acctgaagag aaaattgctc taaaacactt gattccaaca agtcatccta 420 taagaattgc agctgaactt cagtgcctaa cagtggctgg ggggcaagat aatgtcatgg 480 gagttaaata ctgctttagg aagaatgatc atgtagttat tgctatgcca tatctggagc 540 atgagtcgtt tttggacatt ctgaattctc tttcctttca agaagtacgg gaatatatgc 600 ttaatctgtt caaagctttg aaacgcattc atcagtttgg tattgttcac cgtgatgtta 660 agcccagcaa ttttttatat aataggcgcc tgaaaaagta tgccttggta gactttggtt 720 tggcccaagg aacccatgat acgaaaatag agcttcttaa atttgtccag tctgaagctc 780 agcaggaaag gtgttcacaa aacaaatccc acataatcac aggaaacaag attccactga 840 gtggcccagt acctaaggag ctggatcagc agtccaccac aaaagcttct gttaaaagac 900 cctacacaaa tgcacaaatt cagattaaac aaggaaaaga cggaaaggag ggatctgtag 960 gcctttctgt ccagcgctct gtttttggag aaagaaattt caatatacac agctccattt 1020 cacatgagag ccctgcagtg aaactcatga agcagtcaaa gactgtggat gtactgtcta 1080 gaaagttagc aacaaaaaag aaggctattt ctacgaaagt tatgaatagt gctgtgatga 1140 ggaaaactgc cagttcttgc ccagctagcc tgacctgtga ctgctatgca acagataaag 1200 tttgtagtat ttgcctttca aggcgtcagc aggttgcccc tagggcaggt acaccaggat 1260 tcagagcacc agaggtcttg acaaagtgcc ccaatcaaac tacagcaatt gacatgtggt 1320 ctgcaggtgt catatttctt tctttgctta gtggacgata tccattttat aaagcaagtg 1380 atgatttaac tgctttggcc caaattatga caattagggg atccagagaa actatccaag 1440 ctgctaaaac ttttgggaaa tcaatattat gtagcaaaga agttccagca caagacttga 1500 gaaaactctg tgagagactc aggggtatgg attctagcac tcccaagtta acaagtgata 1560 tacaagggca tgcttctcat caaccagcta tttcagagaa gactgaccat aaagcttctt 1620 gcctcgttca aacacctcca ggacaatact cagggaattc atttaaaaag ggggatagta 1680 atagctgtga gcattgtttt gatgagtata ataccaattt agaaggctgg aatgaggtac 1740 ctgatgaagc ttatgacctg cttgataaac ttctagatct aaatccagct tcaagaataa 1800 cagcagaaga agctttgttg catccatttt ttaaagatat gagcttgtga taatggatct 1860 tcatttaatg tttactgtta tgaggtagaa taaaaaagaa tactttgtaa tagccacaag 1920 ttcttgttta gagaccagag caggattaat aatttatttt aacattttag tgtttggtgg 1980 cacattctaa aatatagatt aagaatactt aaaatgcctg ggatagttct tgggactaac 2040 aacatgatct tctttgagtt aaacctacct aagtagattt taggtgggtt cctattaggt 2100 cagattttta gcttccctaa ttacctttca ctgacataca gaaaaaggag cagttttagt 2160 tttaattaat taaaattaac agatgtgatg aggattaaat gaatcaaaag acttaatttg 2220 tagattcttt tagagttatg agctaggtat agtttgggga aactcaacct ggtgctggtg 2280 ctcttaacaa ttttgtaaat aaagaagata atttcctttt ctagaggtac atattaggcc 2340 ttttatgaac actaaaacaa tgaggaaatg ttggtcatgg ggcaaagtat cacttaaaat 2400 tgaattcatc catttttaaa aaacacttca tgaaagcatt ctggtgtgaa ttgccatttt 2460 tttcttactg gcttctcaat tttcttcctt ctctgcccct acctaaaaca ttctcctcgg 2520 aaattacatg gtgctgacca caaagtttct ggatgtttta ttaaatattg tacgtgttta 2580 cagttgggaa tttaaaataa tacatacact ggttgataaa gggaagctgc aggaccaagg 2640 tgaagattga tagtccaaat gcttttcttt tttgagttgt atattttttc acaccatctt 2700 agatataatt aggtagctgc tgaaaggaaa agtgaataca gaattgacgg tattattgga 2760 gatttttcct ctgcgtagag ccatccagat ctctgtatcc tgttttgact aagtcttagg 2820 tgggttggga agacagataa tgaagtaggc aaagagaaaa ggacccaaga tagaggttta 2880 tattcagaaa tggtatatat caatgacagc atatcaaact tcctatggga aaaagtctgg 2940 tgggtggtca gctgacagat ttcccattta gtagtcatag aatacagaaa tagtttaggg 3000 acatgtattc attttgttat tttgagcatt gataggtcag tatatctacc taatctgttt 3060 ggtaagtata ggatatataa accattacca ttgatctgtc ttatgccata atcttaaaaa 3120 aaaattgaat gctcttgaat ttgtatattc aataaagtta tccttttata aaaaaaaa 3178 <210> 88 <211> 3212 <212> DNA <213> Homo sapiens <400> 88 gaattcgcgg ccgcgtcgac gatctcttgg agacggcgac ccaggcatct ggggagccac 60 agaagtcgta ctcccttaaa ccctgctttg ctccccctgt ggatgtaacc ccttagctgg 120 cattttgcat ctcaattggc ttgtgatgga ggcgtctttg gggattcaga tggatgagcc 180 aatggctttt tctccccagc gtgaccggtt tcaggctgaa ggctctttaa aaaaaaacga 240 gcagaatttt aaacttgcag gtgttaaaaa agatattgag aagctttatg aagctgtacc 300 acagcttagt aatgtgttta agattgagga caaaattgga gaaggcactt tcagctctgt 360 ttatttggcc acagcacagt tacaagtagg acctgaagag aaaattgctc taaaacactt 420 gattccaaca agtcatccta taagaattgc agctgaactt cagtgcctaa cagtggctgg 480 ggggcaagat aatgtcatgg gagttaaata ctgctttagg aagaatgatc atgtagttat 540 tgctatgcca tatctggagc atgagtcgtt tttggacatt ctgaattctc tttcctttca 600 agaagtacgg gaatatatgc ttaatctgtt caaagctttg aaacgcattc atcagtttgg 660 tattgttcac cgtgatgtta agcccagcaa ttttttatat aataggcgcc tgaaaaagta 720 tgccttggta gactttggtt tggcccaagg aacccatgat acgaaaatag agcttcttaa 780 atttgtccag tctgaagctc agcaggaaag gtgttcacaa aacaaatccc acataatcac 840 aggaaacaag attccactga gtggcccagt acctaaggag ctggatcagc agtccaccac 900 aaaagcttct gttaaaagac cctacacaaa tgcacaaatt cagattaaac aaggaaaaga 960 cggaaaggag ggatctgtag gcctttctgt ccagcgctct gtttttggag aaagaaattt 1020 caatatacac agctccattt cacatgagag ccctgcagtg aaactcatga agcagtcaaa 1080 gactgtggat gtactgtcta gaaagttagc aacaaaaaag aaggctattt ctacgaaagt 1140 tatgaatagt gctgtgatga ggaaaactgc cagttcttgc ccagctagcc tgacctgtga 1200 ctgctatgca acagataaag tttgtagtat ttgcctttca aggcgtcagc aggttgcccc 1260 tagggcaggt acaccaggat tcagagcacc agaggtcttg acaaagtgcc ccaatcaaac 1320 tacagcaatt gacatgtggt ctgcaggtgt catatttctt tctttgctta gtggacgata 1380 tccattttat aaagcaagtg atgatttaac tgctttggcc caaattatga caattagggg 1440 atccagagaa actatccaag ctgctaaaac ttttgggaaa tcaatattat gtagcaaaga 1500 agttccagca caagacttga gaaaactctg tgagagactc aggggtatgg attctagcac 1560 tcccaagtta acaagtgata tacaagggca tgcttctcat caaccagcta tttcagagaa 1620 gactgaccat aaagcttctt gcctcgttca aacacctcca ggacaatact cagggaattc 1680 atttaaaaag ggggatagta atagctgtga gcattgtttt gatgagtata ataccaattt 1740 agaaggctgg aatgaggtac ctgatgaagc ttatgacctg cttgataaac ttctagatct 1800 aaatccagct tcaagaataa cagcagaaga agctttgttg catccatttt ttaaagatat 1860 gagcttgtga taatggatct tcatttaatg tttactgtta tgaggtagaa taaaaaagaa 1920 tactttgtaa tagccacaag ttcttgttta gagaccagag caggattaat aatttatttt 1980 aacattttag tgtttggtgg cacattctaa aatatagatt aagaatactt aaaatgcctg 2040 ggatagttct tgggactaac aacatgatct tctttgagtt aaacctacct aagtagattt 2100 taggtgggtt cctattaggt cagattttta gcttccctaa ttacctttca ctgacataca 2160 gaaaaaggag cagttttagt tttaattaat taaaattaac agatgtgatg aggattaaat 2220 gaatcaaaag acttaatttg tagattcttt tagagttatg agctaggtat agtttgggga 2280 aactcaacct ggtgctggtg ctcttaacaa ttttgtaaat aaagaagata atttcctttt 2340 ctagaggtac atattaggcc ttttatgaac actaaaacaa tgaggaaatg ttggtcatgg 2400 ggcaaagtat cacttaaaat tgaattcatc catttttaaa aaacacttca tgaaagcatt 2460 ctggtgtgaa ttgccatttt tttcttactg gcttctcaat tttcttcctt ctctgcccct 2520 acctaaaaca ttctcctcgg aaattacatg gtgctgacca caaagtttct ggatgtttta 2580 ttaaatattg tacgtgttta cagttgggaa tttaaaataa tacatacact ggttgataaa 2640 gggaagctgc aggaccaagg tgaagattga tagtccaaat gcttttcttt tttgagttgt 2700 atattttttc acaccatctt agatataatt aggtagctgc tgaaaggaaa agtgaataca 2760 gaattgacgg tattattgga gatttttcct ctgcgtagag ccatccagat ctctgtatcc 2820 tgttttgact aagtcttagg tgggttggga agacagataa tgaagtaggc aaagagaaaa 2880 ggacccaaga tagaggttta tattcagaaa tggtatatat caatgacagc atatcaaact 2940 tcctatggga aaaagtctgg tgggtggtca gctgacagat ttcccattta gtagtcatag 3000 aatacagaaa tagtttaggg acatgtattc attttgttat tttgagcatt gataggtcag 3060 tatatctacc taatctgttt ggtaagtata ggatatataa accattacca ttgatctgtc 3120 ttatgccata atcttaaaaa aaaattgaat gctcttgaat ttgtatattc aataaagtta 3180 tccttttata aaaaaaaagt cgacgcggcc gc 3212 <210> 89 <211> 3187 <212> DNA <213> Homo sapiens <400> 89 gaattcggca cgagttggag acggcgaccc aggcatctgg ggagcacaga agtcgtactc 60 ccttaaaccc tgctttgctc cccctgtgga tgtaacccct tagctggcat tttgcatctc 120 aattggcttg tgatggaggc gtctttgggg attcagatgg atgagccaat ggctttttct 180 ccccagcgtg accggtttca ggctgaaggc tctttaaaaa aaaacgagca gaattttaaa 240 cttgcaggtg ttaaaaaaga tattgagaag ctttatgaag ctgtaccaca gcttagtaat 300 gtgtttaaga ttgaggacaa aattggagaa ggcactttca gctctgttta tttggccaca 360 gcacagttac aagtaggacc tgaagagaaa attgctctaa aacacttgat tccaacaagt 420 catcctataa gaattgcagc tgaacttcag tgcctaacag tggctggggg gcaagataat 480 gtcatgggag ttaaatactg ctttaggaag aatgatcatg tagttattgc tatgccatat 540 ctggagcatg agtcgttttt ggacattctg aattctcttt cctttcaaga agtacgggaa 600 tatatgctta atctgttcaa agctttgaaa cgcattcatc agtttggtat tgttcaccgt 660 gatgttaagc ccagcaattt tttatataat aggcgcctga aaaagtatgc cttggtagac 720 tttggtttgg cccaaggaac ccatgatacg aaaatagagc ttcttaaatt tgtccagtct 780 gaagctcagc aggaaaggtg ttcacaaaac aaatcccaca taatcacagg aaacaagatt 840 ccactgagtg gcccagtacc taaggagctg gatcagcagt ccaccacaaa agcttctgtt 900 aaaagaccct acacaaatgc acaaattcag attaaacaag gaaaagacgg aaaggaggga 960 tctgtaggcc tttctgtcca gcgctctgtt tttggagaaa gaaatttcaa tatacacagc 1020 tccatttcac atgagagccc tgcagtgaaa ctcatgaagc agtcaaagac tgtggatgta 1080 ctgtctagaa agttagcaac aaaaaagaag gctatttcta cgaaagttat gaatagtgct 1140 gtgatgagga aaactgccag ttcttgccca gctagcctga cctgtgactg ctatgcaaca 1200 gataaagttt gtagtatttg cctttcaagg cgtcagcagg ttgcccctag ggcaggtaca 1260 ccaggattca gagcaccaga ggtcttgaca aagtgcccca atcaaactac agcaattgac 1320 atgtggtctg caggtgtcat atttctttct ttgcttagtg gacgatatcc attttataaa 1380 gcaagtgatg atttaactgc tttggcccaa attatgacaa ttaggggatc cagagaaact 1440 atccaagctg ctaaaacttt tgggaaatca atattatgta gcaaagaagt tccagcacaa 1500 gacttgagaa aactctgtga gagactcagg ggtatggatt ctagcactcc caagttaaca 1560 agtgatatac aagggcatgc ttctcatcaa ccagctattt cagagaagac tgaccataaa 1620 gcttcttgcc tcgttcaaac acctccagga caatactcag ggaattcatt taaaaagggg 1680 gatagtaata gctgtgagca ttgttttgat gagtataata ccaatttaga aggctggaat 1740 gaggtacctg atgaagctta tgacctgctt gataaacttc tagatctaaa tccagcttca 1800 agaataacag cagaagaagc tttgttgcat ccatttttta aagatatgag cttgtgataa 1860 tggatcttca tttaatgttt actgttatga ggtagaataa aaaagaatac tttgtaatag 1920 ccacaagttc ttgtttagag accagagcag gattaataat ttattttaac attttagtgt 1980 ttggtggcac attctaaaat atagattaag aatacttaaa atgcctggga tagttcttgg 2040 gactaacaac atgatcttct ttgagttaaa cctacctaag tagattttag gtgggttcct 2100 attaggtcag atttttagct tccctaatta cctttcactg acatatacag aaaaaggagc 2160 agttttagtt ttaattaatt aaaattaaca gatgtgatga ggattaaatg aatcaaaaga 2220 cttaatttgt agattctttt agagttatga gctaggtata gtttggggaa actcaacctg 2280 gtgctggtgc tcttaacaat tttgtaaata aagaagataa tttccttttc tagaggtaca 2340 tattaggcct tttatgaaca ctaaaacaat gaggaaatgt tggtcatggg gcaaagtatc 2400 acttaaaatt gaattcatcc atttttaaaa aacacttcat gaaagcattc tggtgtgaat 2460 tgccattttt ttcttactgg cttctcaatt ttcttccttc tctgccccta cctaaaacat 2520 tctcctcgga aattacatgg tgctgaccac aaagtttctg gatgttttat taaatattgt 2580 acgtctttac agttgggaat ttaaaataat acatacactg gttgataaag ggaagctgca 2640 ggaccaaggt gaagattgat agtccaaatg cttttctttt ttgagttgta tatttttgga 2700 caccatctta gatataatta ggtagctgct gaaaggaaaa gtgaatacag aattgacggt 2760 attattggag atttttcctc tgcgtagagc catccagatc tctgtatcct gttttgacta 2820 agtcttaggt gggttgggaa gacagataat gaagtgtagg caaagagaaa aggacccaag 2880 atagaggttt atattcagaa atggtatata tcaatgacag catatcaaac ttcctatggg 2940 aaaaagtctg gtgggtggtc agctgacaga tttcccattt agtagtcata gaatacagaa 3000 atagtttagg gacatgtatt cattttgtta ttttgagcat tgataggtca gtatatctac 3060 ctaatctgtt tggtaagtat aggatatata aaccattacc attgatctgt cttatgccat 3120 aatcttaaaa aaaaattgaa tgctcttgaa tttgtatatt caataaagtt atccttttat 3180 atttttt 3187 <210> 90 <211> 1725 <212> DNA <213> Homo sapiens <400> 90 atggaggcgt ctttggggat tcagatggat gagccaatgg ctttttctcc ccagcgtgac 60 cggtttcagg ctgaaggctc tttaaaaaaa aacgagcaga attttaaact tgcaggtgtt 120 aaaaaagata ttgagaagct ttatgaagct gtaccacagc ttagtaatgt gtttaagatt 180 gaggacaaaa ttggagaagg cactttcagc tctgtttatt tggccacagc acagttacaa 240 gtaggacctg aagagaaaat tgctgtaaaa cacttgattc caacaagtca tcctataaga 300 attgcagctg aacttcagtg cctaacagtg gctggggggc aagataatgt catgggagtt 360 aaatactgct ttaggaagaa tgatcatgta gttattgcta tgccatatct ggagcatgag 420 tcgtttttgg acattctgaa ttctctttcc tttcaagaag tacgggaata tatgcttaat 480 ctgttcaaag ctttgaaacg cattcatcag tttggtattg ttcaccgtga tgttaagccc 540 agcaattttt tatataatag gcgcctgaaa aagtatgcct tggtagactt tggtttggcc 600 caaggaaccc atgatacgaa aatagagctt cttaaatttg tccagtctga agctcagcag 660 gaaaggtgtt cacaaaacaa atcccacata atcacaggaa acaagattcc actgagtggc 720 ccagtaccta aggagctgga tcagcagtcc accacaaaag cttctgttaa aagaccctac 780 acaaatgcac aaattcagat taaacaagga aaagacggaa aggagggatc tgtaggcctt 840 tctgtccagc gctctgtttt tggagaaaga aatttcaata tacacagctc catttcacat 900 gagagccctg cagtgaaact catgaagcag tcaaagactg tggatgtact gtctagaaag 960 ttagcaacaa aaaagaaggc tatttctacg aaagttatga atagtgctgt gatgaggaaa 1020 actgccagtt cttgcccagc tagcctgacc tgtgactgct atgcaacaga taaagtttgt 1080 agtatttgcc tttcaaggcg tcagcaggtt gcccctaggg caggtacacc aggattcaga 1140 gcaccagagg tcttgacaaa gtgccccaat caaactacag caattgacat gtggtctgca 1200 ggtgtcatat ttctttcttt gcttagtgga cgatatccat tttataaagc aagtgatgat 1260 ttaactgctt tggcccaaat tatgacaatt aggggatcca gagaaactat ccaagctgct 1320 aaaacttttg ggaaatcaat attatgtagc aaagaagttc cagcacaaga cttgagaaaa 1380 ctctgtgaga gactcagggg tatggattct agcactccca agttaacaag tgatatacag 1440 gggcatgctt ctcatcaacc agctatttca gagaagactg accataaagc ttcttgcctc 1500 gttcaaacac ctccaggaca atactcaggg aattcattta aaaaggggga tagtaatagc 1560 tgtgagcatt gttttgatga gtataatacc aatttagaag gctggaatga ggtacctgat 1620 gaagcttatg acctgcttga taaacttcta gatctaaatc cagcttcaag aataacagca 1680 gaagaagctt tgttgcatcc attttttaaa gatatgagct tgtga 1725 <210> 91 <211> 2846 <212> DNA <213> Homo sapiens <400> 91 gcttggagga agtggcggct ttgagtccgg tggcccaatc gctgttacta cttctctgaa 60 gctcctctcg gctgcttgcc gagacaccct gccgccaaga tgcctcgaat tatgatcaag 120 gggggcgtat ggaggaatac cgaggatgaa attctgaaag cagcggtaat gaaatatggg 180 aaaaatcagt ggtctaggat tgcctcattg ctgcatagaa aatcagcaaa gcagtgcaaa 240 gccagatggt atgaatggct ggatccaagc attaagaaga cagaatggtc cagagaagaa 300 gaggaaaaac tcttgcactt ggccaagttg atgccaactc agtggaggac cattgctcca 360 atcattggaa gaacagcggc ccagtgctta gaacactatg aatttcttct ggataaagct 420 gcccaaagag acaatgaaga ggaaacaaca gatgatccac gaaaacttaa acctggagaa 480 atagatccaa atccagaaac aaaaccagcg cggcctgatc caattgatat ggatgaggat 540 gaacttgaga tgctttctga agccagagcc cgcttggcta atactcaggg aaagaaggcc 600 aagaggaaag caagagagaa acaattggaa gaagcaagac gtcttgctgc cctccaaaaa 660 agaagagaac ttcgagcagc tggcatagaa attcagaaga aaagaaaaag gaagagagga 720 gttgattata atgccgaaat cccatttgaa aaaaagcctg cccttggttt ttatgatact 780 tctgaggaaa actaccaagc tcttgacgca gatttcagga aattaagaca acaggatctt 840 gatggggagc taagatctga aaaagaagga agagatagaa aaaaagacaa acagcatttg 900 aaaaggaaaa aagaatctga tttaccatca gctattcttc aaactagtgg tgtttctgaa 960 tttactaaaa agagaagcaa actagtactt cctgcccctc agatttcaga tgcagaactc 1020 caggaagttg taaaagtagg ccaagcgagt gaaattgcac gtcaaactgc cgaggaatct 1080 ggcataacaa attctgcttc cagtacactt ttgtctgagt acaatgtcac caacaacagc 1140 gttgctctta gaacaccacg aacaccagct tcccaggaca gaattctgca ggaagcccag 1200 aacctcatgg ccctcaccaa tgtggacacc ccattgaaag gtggacttaa taccccattg 1260 catgagagtg acttctcagg tgtaactcca cagcgacaag ttgtacagac tccaaacaca 1320 gttctctcta ctccattcag gactccttct aatggagctg aagggctgac tccccggagt 1380 ggaacaactc ccaaaccagt tattaactct actccgggta gaactcctct tcgagacaag 1440 ttaaacatta atcccgagga tggaatggca gactatagtg atccctctta cgtgaagcag 1500 atggaaagag aatcccgaga acatctccgt ttagggttgt tgggccttcc tgcccctaag 1560 aatgattttg aaattgttct accagaaaat gccgagaagg agctggaaga acgtgaaata 1620 gatgatactt acattgaaga tgctgctgat gtggatgctc gaaagcaggc catacgagat 1680 gcagagcgtg taaaggaaat gaaacgaatg cataaagctg tccagaaaga tctgccaaga 1740 ccatcagaag taaatgaaac tattctaaga cccttaaatg tagaaccgcc tttaacagat 1800 ttacagaaaa gtgaagaact aatcaaaaaa gaaatgatca caatgcttca ttatgacctt 1860 ctacatcacc cttatgaacc atctggaaat aaaaaaggca aaactgtagg gtttggtacc 1920 aataattcag agcacattac ctatctggaa cataatcctt atgaaaagtt ctccaaagaa 1980 gagctgaaaa aggcccagga tgttttggtg caggagatgg aagtggttaa acaaggaatg 2040 agccatggag agctctcaag tgaagcttat aaccaggtgt gggaagaatg ctacagtcaa 2100 gttttatatc ttcctgggca gagccgctac acacgggcca atctggctag taaaaaggac 2160 agaattgaat cacttgaaaa gaggctcgag ataaacaggg gtcacatgac gacagaagcc 2220 aagagggctg caaagatgga aaagaagatg aaaattttgc ttgggggtta ccagtctcgt 2280 gctatggggc tcatgaaaca gttgaatgac ttatgggacc aaattgaaca ggctcacttg 2340 gagttacgca cttttgaaga actcaagaaa catgaagatt ctgctattcc ccggaggcta 2400 gagtgtctaa aagaagacgt tcagcgacaa caagaaagag aaaaggaact tcaacataga 2460 tatgctgatt tgctgctgga gaaagagact ttaaagtcaa aattctgaag tacagtttat 2520 attctgtcac aggattaatt aattgccggt tttcatactc tagaaggctg aaactgatgt 2580 ttatcttcat tgacaaattt acccaccatc tgtggttttt cagttgttta ttttaaatga 2640 tatcgatctt acacattctg tgtataaaga ccttaactcc acaggacgga cattttagag 2700 tttaaattat taaggctatc attcttttag taatgtcata tttgcaaact tttttagttt 2760 tggcctttaa tttaaaaagc ctaattttaa agtgctgcct gtgagtaact cttgaataaa 2820 aacaaaatat aaaaaaaaaa aaaaaa 2846 <210> 92 <211> 3012 <212> DNA <213> Homo sapiens <400> 92 gctttggcca gagtggtttg atggttttgt gttagtcttc ctgcagctga gcttccacaa 60 gacacttttt ccctttcagc cacccaatat ctcgcgagac ttgctattct gcgccccctc 120 ctaccttgcg cttgcgcaga tcttcaaagc agaaggtcgc gcttggagga agtggcggct 180 ttgagtccgg tggcccaatc gctgttacta cttctctgaa gctcctctcg gctgcttgcc 240 gagacaccct gccgccaaga tgcctcgaat tatgatcaag gggggcgtat ggaggaatac 300 cgaggatgaa attctgaaag cagcggtaat gaaatatggg aaaaatcagt ggtctaggat 360 tgcctcattg ctgcatagaa aatcagcaaa gcagtgcaaa gccagatggt atgaatggct 420 ggatccaagc attaagaaga cagaatggtc cagagaagaa gaggaaaaac tcttgcactt 480 ggccaagttg atgccaactc agtggaggac cattgctcca atcattggaa gaacagcggc 540 ccagtgctta gaacactatg aatttcttct ggataaagct gcccaaagag acaatgaaga 600 ggaaacaaca gatgatccac gaaaacttaa acctggagaa atagatccaa atccagaaac 660 aaaaccagcg cggcctgatc caattgatat ggatgaggat gaacttgaga tgctttctga 720 agccagagcc cgcttggcta atactcaggg aaagaaggcc aagaggaaag caagagagaa 780 acaattggaa gaagcaagac gtcttgctgc cctccaaaaa agaagagaac ttcgagcagc 840 tggcatagaa attcagaaga aaagaaaaag gaagagagga gttgattata atgccgaaat 900 cccatttgaa aaaaagcctg cccttggttt ttatgatact tctgaggaaa actaccaagc 960 tcttgacgca gatttcagga aattaagaca acaggatctt gatggggagc taagatctga 1020 aaaagaagga agagatagaa aaaaagacaa acagcatttg aaaaggaaaa aagaatctga 1080 tttaccatca gctattcttc aaactagtgg tgtttctgaa tttactaaaa agagaagcaa 1140 actagtactt cctgcccctc agatttcaga tgcagaactc caggaagttg taaaagtagg 1200 ccaagcgagt gaaattgcac gtcaaactgc cgaggaatct ggcataacaa attctgcttc 1260 cagtacactt ttgtctgagt acaatgtcac caacaacagc gttgctctta gaacaccacg 1320 aacaccagct tcccaggaca gaattctgca ggaagcccag aacctcatgg ccctcaccaa 1380 tgtggacacc ccattgaaag gtggacttaa taccccattg catgagagtg acttctcagg 1440 tgtaactcca cagcgacaag ttgtacagac tccaaacaca gttctctcta ctccattcag 1500 gactccttct aatggagctg aagggctgac tccccggagt ggaacaactc ccaaaccagt 1560 tattaactct actccgggta gaactcctct tcgagacaag ttaaacatta atcccgagga 1620 tggaatggca gactatagtg atccctctta cgtgaagcag atggaaagag aatcccgaga 1680 acatctccgt ttagggttgt tgggccttcc tgcccctaag aatgattttg aaattgttct 1740 accagaaaat gccgagaagg agctggaaga acgtgaaata gatgatactt acattgaaga 1800 tgctgctgat gtggatgctc gaaagcaggc catacgagat gcagagcgtg taaaggaaat 1860 gaaacgaatg cataaagctg tccagaaaga tctgccaaga ccatcagaag taaatgaaac 1920 tattctaaga cccttaaatg tagaaccgcc tttaacagat ttacagaaaa gtgaagaact 1980 aatcaaaaaa gaaatgatca caatgcttca ttatgacctt ctacatcacc cttatgaacc 2040 atctggaaat aaaaaaggca aaactgtagg gtttggtacc aataattcag agcacattac 2100 ctatctggaa cataatcctt atgaaaagtt ctccaaagaa gagctgaaaa aggcccagga 2160 tgttttggtg caggagatgg aagtggttaa acaaggaatg agccatggag agctctcaag 2220 tgaagcttat aaccaggtgt gggaagaatg ctacagtcaa gttttatatc ttcctgggca 2280 gagccgctac acacgggcca atctggctag taaaaaggac agaattgaat cacttgaaaa 2340 gaggctcgag ataaacaggg gtcacatgac gacagaagcc aagagggctg caaagatgga 2400 aaagaagatg aaaattttgc ttgggggtta ccagtctcgt gctatggggc tcatgaaaca 2460 gttgaatgac ttatgggacc aaattgaaca ggctcacttg gagttacgca cttttgaaga 2520 actcaagaaa catgaagatt ctgctattcc ccggaggcta gagtgtctaa aagaagacgt 2580 tcagcgacaa caagaaagag aaaaggaact tcaacataga tatgctgatt tgctgctgga 2640 gaaagagact ttaaagtcaa aattctgaag tacagtttat attctgtcac aggattaatt 2700 aattgccggt tttcatactc tagaaggctg aaactgatgt ttatcttcat tgacaaattt 2760 acccaccatc tgtggttttt cagttgttta ttttaaatga tatcgatctt acacattctg 2820 tgtataaaga ccttaactcc acaggacgga cattttagag tttaaattat taaggctatc 2880 attcttttag taatgtcata tttgcaaact tttttagttt tggcctttaa tttaaaaagc 2940 ctaattttaa agtgctgcct ttgagtaact cttgaataaa aacaaaatat aaaaaattga 3000 aaaaaaaaaa aa 3012 <210> 93 <211> 2409 <212> DNA <213> Homo sapiens <400> 93 atgcctcgaa ttatgatcaa ggggggcgta tggaggaata ccgaggatga aattctgaaa 60 gcagcggtaa tgaaatatgg gaaaaatcag tggtctagga ttgcctcatt gctgcataga 120 aaatcagcaa agcagtgcaa agccagatgg tatgaatggc tggatccaag cattaagaag 180 acagaatggt ccagagaaga agaggaaaaa ctcttgcact tggccaagtt gatgccaact 240 cagtggagga ccattgctcc aatcattgga agaacagcgg cccagtgctt agaacactat 300 gaatttcttc tggataaagc tgcccaaaga gacaatgaag aggaaacaac agatgatcca 360 cgaaaactta aacctggaga aatagatcca aatccagaaa caaaaccagc gcggcctgat 420 ccaattgata tggatgagga tgaacttgag atgctttctg aagccagagc ccgcttggct 480 aatactcagg gaaagaaggc caagaggaaa gcaagagaga aacaattgga agaagcaaga 540 cgtcttgctg ccctccaaaa aagaagagaa cttcgagcag ctggcataga aattcagaag 600 aaaagaaaaa ggaagagagg agttgattat aatgccgaaa tcccatttga aaaaaagcct 660 gcccttggtt tttatgatac ttctgaggaa aactaccaag ctcttgacgc agatttcagg 720 aaattaagac aacaggatct tgatggggag ctaagatctg aaaaagaagg aagagataga 780 aaaaaagaca aacagcattt gaaaaggaaa aaagaatctg atttaccatc agctattctt 840 caaactagtg gtgtttctga atttactaaa aagagaagca aactagtact tcctgcccct 900 cagatttcag atgcagaact ccaggaagtt gtaaaagtag gccaagcgag tgaaattgca 960 cgtcaaactg ccgaggaatc tggcataaca aattctgctt ccagtacact tttgtctgag 1020 tacaatgtca ccaacaacag cgttgctctt agaacaccac gaacaccagc ttcccaggac 1080 agaattctgc aggaagccca gaacctcatg gccctcacca atgtggacac cccattgaaa 1140 ggtggactta ataccccatt gcatgagagt gacttctcag gtgtaactcc acagcgacaa 1200 gttgtacaga ctccaaacac agttctctct actccattca ggactccttc taatggagct 1260 gaagggctga ctccccggag tggaacaact cccaaaccag ttattaactc tactccgggt 1320 agaactcctc ttcgagacaa gttaaacatt aatcccgagg atggaatggc agactatagt 1380 gatccctctt acgtgaagca gatggaaaga gaatcccgag aacatctccg tttagggttg 1440 ttgggccttc ctgcccctaa gaatgatttt gaaattgttc taccagaaaa tgccgagaag 1500 gagctggaag aacgtgaaat agatgatact tacattgaag atgctgctga tgtggatgct 1560 cgaaagcagg ccatacgaga tgcagagcgt gtaaaggaaa tgaaacgaat gcataaagct 1620 gtccagaaag atctgccaag accatcagaa gtaaatgaaa ctattctaag acccttaaat 1680 gtagaaccgc ctttaacaga tttacagaaa agtgaagaac taatcaaaaa agaaatgatc 1740 acaatgcttc attatgacct tctacatcac ccttatgaac catctggaaa taaaaaaggc 1800 aaaactgtag ggtttggtac caataattca gagcacatta cctatctgga acataatcct 1860 tatgaaaagt tctccaaaga agagctgaaa aaggcccagg atgttttggt gcaggagatg 1920 gaagtggtta aacaaggaat gagccatgga gagctctcaa gtgaagctta taaccaggtg 1980 tgggaagaat gctacagtca agttttatat cttcctgggc agagccgcta cacacgggcc 2040 aatctggcta gtaaaaagga cagaattgaa tcacttgaaa agaggctcga gataaacagg 2100 ggtcacatga cgacagaagc caagagggct gcaaagatgg aaaagaagat gaaaattttg 2160 cttgggggtt accagtctcg tgctatgggg ctcatgaaac agttgaatga cttatgggac 2220 caaattgaac aggctcactt ggagttacgc acttttgaag aactcaagaa acatgaagat 2280 tctgctattc cccggaggct agagtgtcta aaagaagacg ttcagcgaca acaagaaaga 2340 gaaaaggaac ttcaacatag atatgctgat ttgctgctgg agaaagagac tttaaagtca 2400 aaattctga 2409 <210> 94 <211> 2836 <212> DNA <213> Homo sapiens <400> 94 cttcaaagca gaaggtcgcg cttggaggaa gtggcggctt tgagtccggt ggcccaatcg 60 ctgttactac ttctctgaag ctcctctcgg ctgcttgccg agacaccctg ccgccaagat 120 gcctcgaatt atgatcaagg ggggcgtatg gaggaatacc gaggatgaaa ttctgaaagc 180 agcggtaatg aaatatggga aaaatcagtg gtctaggatt gcctcattgc tgcatagaaa 240 atcagcaaag cagtgcaaag ccagatggta tgaatggctg gatccaagca ttaagaagac 300 agaatggtcc agagaagaag aggaaaaact cttgcacttg gccaagttga tgccaactca 360 gtggaggacc attgctccaa tcattggaag aacagcggcc cagtgcttag aacactatga 420 atttcttctg gataaagctg cccaaagaga caatgaagag gaaacaacag atgatccacg 480 aaaacttaaa cctggagaaa tagatccaaa tccagaaaca aaaccagcgc ggcctgatcc 540 aattgatatg gatgaggatg aacttgagat gctttctgaa gccagagccc gcttggctaa 600 tactcaggga aagaaggcca agaggaaagc aagagagaaa caattggaag aagcaagacg 660 tcttgctgcc ctccaaaaaa gaagagaact tcgagcagct ggcatagaaa ttcagaagaa 720 aagaaaaagg aagagaggag ttgattataa tgccgaaatc ccatttgaaa aaaagcctgc 780 ccttggtttt tatgatactt ctgaggaaaa ctaccaagct cttgacgcag atttcaggaa 840 attaagacaa caggatcttg atggggagct aagatctgaa aaagaaggaa gagatagaaa 900 aaaagacaaa cagcatttga aaaggaaaaa agaatctgat ttaccatcag ctattcttca 960 aactagtggt gtttctgaat ttactaaaaa gagaagcaaa ctagtacttc ctgcccctca 1020 gatttcagat gcagaactcc aggaagttgt aaaagtaggc caagcgagtg aaattgcacg 1080 tcaaactgcc gaggaatctg gcataacaaa ttctgcttcc agtacacttt tgtctgagta 1140 caatgtcacc aacaacagcg ttgctcttag aacaccacga acaccagctt cccaggacag 1200 aattctgcag gaagcccaga acctcatggc cctcaccaat gtggacaccc cattgaaagg 1260 tggacttaat accccattgc atgagagtga cttctcaggt gtaactccac agcgacaagt 1320 tgtacagact ccaaacacag ttctctctac tccattcagg actccttcta atggagctga 1380 agggctgact ccccggagtg gaacaactcc caaaccagtt attaactcta ctccgggtag 1440 aactcctctt cgagacaagt taaacattaa tcccgaggat ggaatggcag actatagtga 1500 tccctcttac gtgaagcaga tggaaagaga atcccgagaa catctccgtt tagggttgtt 1560 gggccttcct gcccctaaga atgattttga aattgttcta ccagaaaatg ccgagaagga 1620 gctggaagaa cgtgaaatag atgatactta cattgaagat gctgctgatg tggatgctcg 1680 aaagcaggcc atacgagatg cagagcgtgt aaaggaaatg aaacgaatgc ataaagctgt 1740 ccagaaagat ctgccaagac catcagaagt aaatgaaact attctaagac ccttaaatgt 1800 agaaccgcct ttaacagatt tacagaaaag tgaagaacta atcaaaaaag aaatgatcac 1860 aatgcttcat tatgaccttc tacatcaccc ttatgaacca tctggaaata aaaaaggcaa 1920 aactgtaggg tttggtacca ataattcaga gcacattacc tatctggaac ataatcctta 1980 tgaaaagttc tccaaagaag agctgaaaaa ggcccaggat gttttggtgc aggagatgga 2040 agtggttaaa caaggaatga gccatggaga gctctcaagt gaagcttata accaggtgtg 2100 ggaagaatgc tacagtcaag ttttatatct tcctgggcag agccgctaca cacgggccaa 2160 tctggctagt aaaaaggaca gaattgaatc acttgaaaag aggctcgaga taaacagggg 2220 tcacatgacg acagaagcca agagggctgc aaagatggaa aagaagatga aaattttgct 2280 tgggggttac cagtctcgtg ctatggggct catgaaacag ttgaatgact tatgggacca 2340 aattgaacag gctcacttgg agttacgcac ttttgaagaa ctcaagaaac atgaagattc 2400 tgctattccc cggaggctag agtgtctaaa agaagacgtt cagcgacaac aagaaagaga 2460 aaaggaactt caacatagat atgctgattt gctgctggag aaagagactt taaagttaaa 2520 attctgaagt acagtttata ttctgtcaca ggattaatta attgccggtt ttcatactct 2580 agaaggctga aactgatgtt tatcttcatt gacaaattta cccaccatct gtggtttttc 2640 agttgtttat tttaaatgat atcgatctta cacattctgt gtataaagac cttaactcca 2700 caggacggac attttagagt ttaaattatt aaggctatca ttcttttagt aatgtcatat 2760 ttgcaaactt ttttagtttt ggcctttaat ttaaaaagcc taattttaaa gtgctgcctg 2820 tgagtaactc ttgaat 2836 <210> 95 <211> 6201 <212> DNA <213> Homo sapiens <400> 95 gctttgagtc cggtggccca atcgctgtta ctacttctct gaagctcctc tcggctgctt 60 gccgagacac cctgccgcca agatgcctcg aattatgatc aaggggggcg tatggaggaa 120 taccgaggat gaaattctga aagcagcggt aatgaaatat gggaaaaatc agtggtctag 180 gattgcctca ttgctgcata gaaaatcagc aaagcagtgc aaagccagat ggtatgaatg 240 gctggatcca agcattaaga agacagaatg gtccagagaa gaagaggaaa aactcttgca 300 cttggccaag ttgatgccaa ctcagtggag gaccattgct ccaatcattg gaagaacagc 360 agcccagtgc ttagaacact atgaatttct tctggataaa gctgcccaaa gagacaatga 420 agaggaaaca acagatgatc cacgaaaact taaacctgga gaaatagatc caaatccaga 480 aacaaaacca gcgcggcctg atccaattga tatggatgag gatgaacttg agatgctttc 540 tgaagccaga gcccgcttgg ctaatactca gggaaagaag gccaagagga aagcaagaga 600 gaaacaattg gaagaagcaa gacgtcttgc tgccctccaa aaaagaagag aacttcgagc 660 agctggcata gaaattcaga agaaaagaaa aaggaagaga ggagttgatt ataatgccga 720 aatcccattt gaaaaaaagc ctgcccttgg tttttatgat acttctgagg aaaactacca 780 agctcttgac gcagatttca ggaaattaag acaacaggat cttgatgggg agctaagatc 840 tgaaaaagaa ggaagagata gaaaaaaaga caaacagcat ttgaaaagga aaaaagaatc 900 tgatttacca tcagctattc ttcaaactag tggtgtttct gaatttacta aaaagagaag 960 caaactagta cttcctgccc ctcagatttc agatgcagaa ctccaggaag ttgtaaaagt 1020 aggccaagcg agtgaaattg cacgtcaaac tgccgaggaa tctggcataa caaattctgc 1080 ttccagtaca cttttgtctg agtacaatgt caccaacaac agcgttgctc ttagaacacc 1140 acgaacacca gcttcccagg acagaattct gcaggaagcc cagaacctca tggccctcac 1200 caatgtggac accccattga aaggtggact taatacccca ttgcatgaga gtgacttctc 1260 aggtgtaact ccacagcgac aagttgtaca gactccaaac acagttctct ctactccatt 1320 caggactcct tctaatggag ctgaagggct gactccccgg agtggaacaa ctcccaaacc 1380 agttattaac tctactccgg gtagaactcc tcttcgagac aagttaaaca ttaatcccga 1440 ggatggaatg gcagactata gtgatccctc ttacgtgaag cagatggaaa gagaatcccg 1500 agaacatctc cgtttagggt tgttgggcct tcctgcccct aagaatgatt ttgaaattgt 1560 tctaccagaa aatgccgaga aggagctgga agaacgtgaa atagatgata cttacattga 1620 agatgctgct gatgtggatg ctcgaaagca ggccatacga gatgcagagc gtgtaaagga 1680 aatgaaacga atgcataaag ctgtccagaa agatctgcca agaccatcag aagtaaatga 1740 aactattcta agacccttaa atgtagaacc gcctttaaca gatttacaga aaagtgaaga 1800 actaatcaaa aaagaaatga tcacaatgct tcattatgac cttctacatc acccttatga 1860 accatctgga aataaaaaag gcaaaactgt agggtttggt accaataatt cagagcacat 1920 tacctatctg gaacataatc cttatgaaaa gttctccaaa gaagagctga aaaaggccca 1980 ggatgttttg gtgcaggaga tggaagtggt taaacaagga atgagccatg gagagctctc 2040 aagtgaagct tataaccagg tgtgggaaga atgctacagt caagttttat atcttcctgg 2100 gcagagccgc tacacacggg ccaatctggc tagtaaaaag gacagaattg aatcacttga 2160 aaagaggctc gagataaaca ggggtcacat gacgacagaa gccaagaggg ctgcaaagat 2220 ggaaaagaag atgaaaattt tgctaggggg ttaccagtct cgtgctatgg ggctcatgaa 2280 acagttgaat gacttatggg accaaattga acaggctcac ttggagttac gcacttttga 2340 agaactcaag aaacatgaag attctgctat tccccggagg ctagagtgtc taaaagaaga 2400 cgttcagcga caacaagaaa gagaaaagga acttcaacat agatatgctg atttgctgct 2460 ggagaaagag actttaaagt caaaattctg aagtacagtt tatattctgt cacaggatta 2520 attaattgcc ggttttcata ctctagaagg ctgaaactga tgtttatctt cattgacaaa 2580 tttacccacc atctgtggtt tttcagttgt ttattttaaa tgatatcgat cttacacatt 2640 ctgtgtataa agaccttaac tccacaggac ggacatttta gagtttaaat tattaaggct 2700 atcattcttt tagtaatgtc atatttgcaa acttttttag ttttggcctt taatttaaaa 2760 agcctaattt taaagtgctg cctgtgagta actcttgaat aaaaacaaaa tataaaaaat 2820 tgagaatgta gccttttgtt tgaagtaatt agatacttaa gagtgcctgc aaaccagcag 2880 ctatgtactc tgtgtcatat ttaatgagta actcttgggt aatcaaaatg gtgatgcagt 2940 atcttaaaca cttaagaggc agttctttgt ggctttgtta gtttcagcaa agagtggtca 3000 tttctgtata cactgacaag ttagattaac tttttagtac ctcaaatttt ttttttgtta 3060 atatcacttt aaagaaggtc tcttgtctgc cagctactta aataatttat gggtcagggc 3120 ttaaaagatt taacttcctt gccccattat tttcttataa gtattttttg acaaaggcat 3180 tttaaaagtt aatttcaaga aggccatcaa acttaaagct ctatgtttag cctaagaagt 3240 cagttacatc agtgtagaat ttggggaatg gatagaggtg gagatattta attttatata 3300 attcatataa attgatttag ttacagtatc agttggctac aagctcatta tagactagca 3360 atgttttgac atcaccaaaa acgtttgccc agtcttagaa tactagggac tataggaagg 3420 gaagggattc attcattcat tcgatattga atgtataccc tgtgccagag tcttagagag 3480 agaacaacaa acaaaatagg cctagttctt gtttagtaga gcttatagtc ttttgagaat 3540 gacagacaat taaaatccaa atgtttattt ggtgattctt atgtgtcaga cacttaagtg 3600 ttgggagata agcagttatt aagacagagt tcttgctctc atggaggtga cattagtggg 3660 gaggagatac taagtatgtc cagggaaagt atcagaccat gagttttaga ttctgtggag 3720 gaaattaaag tagggtgatt atgagatagt gaatgagtgg ctattttaga ctggacgatc 3780 aaagagacct cttggaaggc agctatgctc accactatac cactgcactg tgccgcaccg 3840 taccactata agctgcacgg ccaaagagac ctcttaaaga agtaacattt aagataacat 3900 gtgattgaca ttttagaatg ggctatcctt gtgagattca aggaaagaac atcctaggtg 3960 gagtgaatag caaacataaa gcctcttttg tatgtttgag gaacaaaaag gacaatgcag 4020 ctagagtgtc aagaatggca tttctgtata taagacctcg ttgtatagag ccacataaat 4080 aaggctataa taaggaattt ggatcttact ttaaatatga taagaatcga tgagaagatc 4140 taagcaaagg aatgacatga tcagatttgg ttttagaaac atcactatct ccttagtgtg 4200 taaaatctca ccaggctgga gatagggaag ccagtccaat taggagcctg atgcagtgat 4260 ccagacaaaa aaataatagt gattctaact agagtccagg taatagtagt ggagatatgt 4320 ggagagacat gataggtata tacttaatag tcttatcaga cgataaattg atattttcct 4380 ggtgtgtagt cacttaattc aaatactttt ttcagtaagt tctgggtttt ctaggaaaaa 4440 cttcagtatc atcagtgaat aatgatagtg tttcttctga tagttttatt tcacttttat 4500 tgcatgtttt gttatctgaa atgtttagga caatgttaac aataatgatg ttagacattt 4560 ttttttctta ttttaatggg aatgtccata gttttaagtt tgctgttggg agttagatag 4620 tctttatctg aaagacagtg tctctctttt agtttttaaa gagtttgaat tagaaatggc 4680 tctggaactt taaacagtat accatttggg catctattaa agcattcata taattgttct 4740 catttgatgt tttgatgagg tatattaata gattttccca cattaaatca tctttgcact 4800 cctggaatca ggtagattaa tttttaaaag aaattttaaa ggatttatag tttatttgca 4860 ctttttgtag acttgaatta tatggattta aaagttgatc taatattaat aaaggctcac 4920 tttgttttca aaatttgaag taattcacat acttatagcc taaaatcggc aggaattaca 4980 aaatttcaaa actggcacat tgtaaactgc atatgcattt gccaggtagt ggtgccactt 5040 gaaatggtga acagacacac tgttatcctt tgtcagtatc ctgtaaagcc caggattctt 5100 taccagcacc atacagcgat tttggtgact attttaacat tcacactgag gccaggggtg 5160 gtgagtcatg cctgtaatcc tagcactttg ggaggccaag gtgggaggat catttgagct 5220 caggagttca agattagcct gggtaacata gtgagaccct gtctctatta aaaaataata 5280 ataaaaataa cattcacatt ggtattgttc actaaggtat tggttgttaa ggcattcatt 5340 aaggtattgt taaaacttgt gttaagcatg ttaaagtctc agtaactttg ggatagaaat 5400 aaaatgtgat aaaaagctga aagaaaccac cacaagggag agtccttttt gaaatattag 5460 agacataatg ctgtctaata aaaaacgaca tcaaagaaaa actacactac agtgactgca 5520 gacttaatgt tggccaacca tgcatcctcc ctagaaatgc atttgaattt gatttactaa 5580 tcttttattt aggaaattta catttttaca ttagtgagat tggtcttttg ggctattgta 5640 cttttttttt tttttttttt gagatggagt cttgctctct cacccaggct ggagtgcagt 5700 agtgcaatct tggcccactg caacctctgc ctcctgggct cgagtgattc tctgcctcag 5760 ccttccaagt agctgggact acaggcatgt gccaccgcac tggctaattt ttgtgttttt 5820 agtagagatg gggttttgct atgttggcca ggctggtctt gaattcctga cctcaggtga 5880 tccacctacc tcggcctccc aaagtgctag aattacaggt gtgagccacc atgcccagcc 5940 tggttattgt attttgatat tgggattttg ctagctctct aaagtaaata ggataactgt 6000 atatcttttt ctgtgcatta agcagttata acatgggaat gatttgttca tgaaaggttg 6060 aaagtctgta cttacagaac ttttgagttc acagtgcttt ctggagataa tttctttata 6120 actgtcagtt tcttttgtga ctattatgtt acctattttt aaatttaagc aactttaaat 6180 taaaaaaatt gtttttaaaa t 6201 <210> 96 <211> 464 <212> DNA <213> Homo sapiens <400> 96 gggggcgttt ggaagaatac cgaggatgaa attctgaaag cagcggtaat gaaatatggg 60 aaaaatcagt ggtctaggat tgcctcattg ctgcatagaa aatcagcaaa gcagtgcaaa 120 gccagatggt atgaatggct ggatccaagc attaagaaga cagaatggtc cagagaagaa 180 gaggaaaaac tcttgcactt ggccaagttg atgccaactc agtggaggac cattgctcca 240 atcattggaa gaacagcggc ccagtgctta gaacactatg aatttcttct ggataaagct 300 gcccaaagag acaatgaaga ggaaacaaca gatgatccac gaaaacttaa acctggagaa 360 atagatccaa atccagaaac aaaaccagcg cggcctgacc caattgatat ggatgaggat 420 gaacttgaga tgctttctga agccagagcc cgcttggcta atac 464 <210> 97 <211> 3248 <212> DNA <213> Homo sapiens <400> 97 ctagaacgaa aggagtgagg cgccgagagc ccagatacca ttttggcgtg agagctggtg 60 gttggcaagg ccgcgggagt gggaagcgtc cgccatgttc tgcgaaaaag ccatggaact 120 gatccgcgag ctgcatcgcg cgcccgaagg gcaactgcct gccttcaacg aggatggact 180 cagacaagtt ctggaggaga tgaaagcttt gtatgaacaa aaccagtctg atgtgaatga 240 agcaaagtca ggtggacgaa gtgatttgat accaactatc aaatttcgac actgttctct 300 gttaagaaat cgacgctgca ctgtagcata cctgtatgac cgcttgcttc ggatcagagc 360 actcagatgg gaatatggta gcgtcttgcc aaatgcatta cgatttcaca tggctgctga 420 agaaatggag tggtttaata attataaaag atctcttgct acttatatga ggtcactggg 480 aggagatgaa ggtttggaca ttacacagga tatgaaacca ccaaaaagcc tatatattga 540 agtccggtgt ctaaaagact atggagaatt tgaagttgat gatggcactt cagtcctatt 600 aaaaaaaaat agccagcact ttttacctcg atggaaatgt gagcagctga tcagacaagg 660 agtcctggag cacatcctgt catgaccatg cgccgaggca cttccaggct tcactcaact 720 catggactcc tctgtactca ctctctccac cctcccttca cctccctctt tgattttaga 780 agctatagac attgtttaag ataactaaga atacttggct aagaagtata atttgctaac 840 tattaaggac tttctttttt taatgttgta cactattctt cctactcttt tttggttttg 900 gttttgtttt gtagagactg tctcactatg ttgcccaagc tggtctcaaa ctcctggcct 960 caagcagtcc tcccacctta gcttctcaaa gtgttgagat cacaggcgtg agccactgca 1020 cccgacccct actccttttt ctaataagct gtatctgtaa tcacagcatt cctacagttg 1080 ttacagtgtg ttttttaaat gaaagtaaac atggttacat ttgaatctct taaataatca 1140 gtcacttggc tggacaggaa gaaggtagat cctgtgtgtc ttgttttctg gtcatgtgta 1200 ttgtacaagc tagagagctg aatttctgag atacacattt tcaaatcaca tgcaagtgaa 1260 gatgatggtc tgtagaaatt ttcagtatat ataatgttta atgacatact aatttatcat 1320 ctggctattt gggaaggaag gacacacatg gattttgcac atttccacca tggtggctgg 1380 tgtggcttgt ggctatgggg tgatcaccag tatcaccact ttggaagggg acagtgaaat 1440 tggggctaga gaaggaactt tgtacagttt tccctgagat tcagattgac tgaaaagtca 1500 catgaagagt tgattgtctt ttaatggtat gttttaaaca gctgacattt taaattttga 1560 tgaaatccag tttattcgtt tgttctttta tgctttgggt gttgcatccg agaaatcttt 1620 tcccatccca agatcacaat tttttttcct ttttacttct agaagtgtta taattttaag 1680 ctttatactt tggtctatga cccgtttttt tttttgtttt gttttgtttt ttcgtttgtt 1740 tctttgtttt gagatggagt cttgttctgt cacccaggct ggggtgcagt ggcgtgatct 1800 tggctcactg caatctctat cccctgggtt caagtgattc tcttgtctca gcctcccaag 1860 tagctgggat tacaggcaca ggccgccacg cccggctaat ttttgtattt ttagtagaga 1920 cagagtttta ccatgttggc caggctggtt tcaaactcct gacctcaagt gacccacctt 1980 ggcctcccaa agttttggga ttacaagtgt gggccaccgc ggccagccta tgatccattt 2040 tgaatgaatt ttttatatgg tgcaaggtgt caatccacct tcactttttc ttgggaatat 2100 agatatccag ctgtttcact accatttttt gaaaggactg ccctttgctc tatcaccttt 2160 gcatttttgt taaaaagtag ttgtcaatgt atatgtgggt ttatttcagg actctgtttt 2220 gttccattga cctgtttttc tctcctgaat gccaatacca tatttgtatg tagtgtatgt 2280 aattttctaa taattcttga aacagatagt attaatgcgt catatttttg ctgttgtttg 2340 tattttttgt ggagatgggg tttcaccatg ttggccaggc tgtgttgaac tcctgagcta 2400 aagcaataca cttgcctcgt cctccccatg tgctgggatt acaggcgtga gccttggtgc 2460 tggcccagtg taccacattt ctttttgaga tttgttttgg ctatgttaag tcctttgctt 2520 ttgatgtgaa atttgggaac aggcagggtg tggtggctta tgcctgtaat cctagaactt 2580 tgggaggcct agatgggtgg atcacttgag ctcaggagtt ccagaccagc ccgggcctat 2640 ggcgaaactc cgtctctaca aaaaatagaa aaaattagcc aggtgtggtg gtgcatgcct 2700 gtagtcacag ttacacggca ggctgaggtg ggaggatcac ttgaacccca gaggtcaaga 2760 ctgcagtgag ctgagatcac accactgtac tccagcctgg gtgacaaagt gagactctat 2820 ctcaaaaaga aattaggatc aacttgtcaa tttctacaac aacaacaaca aaaacccctg 2880 ttgggcacct tgattgagat tgcattgaat ttatataaaa ctgttgggag aattgacatc 2940 ttaataatat tgagtcttct ggcctataaa caaggtctgt cttcctaggt attaatgttt 3000 tgtcttctat ttctcttaat aatcttttgt agttttcagt gtacaggtct accatgtcag 3060 catttcatag ttttgatgct aaatggtatt ttaaaatttc aaattctaac cacttgttgc 3120 tagtaaatag aaatacaatt gatgttgaac ttgtatcctt cagccttgct aaactgtgag 3180 ttctcatggt gtttttgtaa attacatcaa cagtcatgtg ttctatgaat aaagagtttt 3240 actccttc 3248 <210> 98 <211> 3248 <212> DNA <213> Homo sapiens <400> 98 ctagaacgaa aggagtgagg cgccgagagc ccagatacca ttttggcgtg agagctggtg 60 gttggcaagg ccgcgggagt gggaagcgtc cgccatgttc tgcgaaaaag ccatggaact 120 gatccgcgag ctgcatcgcg cgcccgaagg gcaactgcct gccttcaacg aggatggact 180 cagacaagtt ctggaggaga tgaaagcttt gtatgaacaa aaccagtctg atgtgaatga 240 agcaaagtca ggtggacgaa gtgatttgat accaactatc aaatttcgac actgttctct 300 gttaagaaat cgacgctgca ctgtagcata cctgtatgac cgcttgcttc ggatcagagc 360 actcagatgg gaatatggta gcgtcttgcc aaatgcatta cgatttcaca tggctgctga 420 agaaatggag tggtttaata attataaaag atctcttgct acttatatga ggtcactggg 480 aggagatgaa ggtttggaca ttacacagga tatgaaacca ccaaaaagcc tatatattga 540 agtccggtgt ctaaaagact atggagaatt tgaagttgat gatggcactt cagtcctatt 600 aaaaaaaaat agccagcact ttttacctcg atggaaatgt gagcagctga tcagacaagg 660 agtcctggag cacatcctgt catgaccatg cgccgaggca cttccaggct tcactcaact 720 catggactcc tctgtactca ctctctccac cctcccttca cctccctctt tgattttaga 780 agctatagac attgtttaag ataactaaga atacttggct aagaagtata atttgctaac 840 tattaaggac tttctttttt taatgttgta cactattctt cctactcttt tttggttttg 900 gttttgtttt gtagagactg tctcactatg ttgcccaagc tggtctcaaa ctcctggcct 960 caagcagtcc tcccacctta gcttctcaaa gtgttgagat cacaggcgtg agccactgca 1020 cccgacccct actccttttt ctaataagct gtatctgtaa tcacagcatt cctacagttg 1080 ttacagtgtg ttttttaaat gaaagtaaac atggttacat ttgaatctct taaataatca 1140 gtcacttggc tggacaggaa gaaggtagat cctgtgtgtc ttgttttctg gtcatgtgta 1200 ttgtacaagc tagagagctg aatttctgag atacacattt tcaaatcaca tgcaagtgaa 1260 gatgatggtc tgtagaaatt ttcagtatat ataatgttta atgacatact aatttatcat 1320 ctggctattt gggaaggaag gacacacatg gattttgcac atttccacca tggtggctgg 1380 tgtggcttgt ggctatgggg tgatcaccag tatcaccact ttggaagggg acagtgaaat 1440 tggggctaga gaaggaactt tgtacagttt tccctgagat tcagattgac tgaaaagtca 1500 catgaagagt tgattgtctt ttaatggtat gttttaaaca gctgacattt taaattttga 1560 tgaaatccag tttattcgtt tgttctttta tgctttgggt gttgcatccg agaaatcttt 1620 tcccatccca agatcacaat tttttttcct ttttacttct agaagtgtta taattttaag 1680 ctttatactt tggtctatga cccgtttttt tttttgtttt gttttgtttt ttcgtttgtt 1740 tctttgtttt gagatggagt cttgttctgt cacccaggct ggggtgcagt ggcgtgatct 1800 tggctcactg caatctctat cccctgggtt caagtgattc tcttgtctca gcctcccaag 1860 tagctgggat tacaggcaca ggccgccacg cccggctaat ttttgtattt ttagtagaga 1920 cagagtttta ccatgttggc caggctggtt tcaaactcct gacctcaagt gacccacctt 1980 ggcctcccaa agttttggga ttacaagtgt gggccaccgc ggccagccta tgatccattt 2040 tgaatgaatt ttttatatgg tgcaaggtgt caatccacct tcactttttc ttgggaatat 2100 agatatccag ctgtttcact accatttttt gaaaggactg ccctttgctc tatcaccttt 2160 gcatttttgt taaaaagtag ttgtcaatgt atatgtgggt ttatttcagg actctgtttt 2220 gttccattga cctgtttttc tctcctgaat gccaatacca tatttgtatg tagtgtatgt 2280 aattttctaa taattcttga aacagatagt attaatgcgt catatttttg ctgttgtttg 2340 tattttttgt ggagatgggg tttcaccatg ttggccaggc tgtgttgaac tcctgagcta 2400 aagcaataca cttgcctcgt cctccccatg tgctgggatt acaggcgtga gccttggtgc 2460 tggcccagtg taccacattt ctttttgaga tttgttttgg ctatgttaag tcctttgctt 2520 ttgatgtgaa atttgggaac aggcagggtg tggtggctta tgcctgtaat cctagaactt 2580 tgggaggcct agatgggtgg atcacttgag ctcaggagtt ccagaccagc ccgggcctat 2640 ggcgaaactc cgtctctaca aaaaatagaa aaaattagcc aggtgtggtg gtgcatgcct 2700 gtagtcacag ttacacggca ggctgaggtg ggaggatcac ttgaacccca gaggtcaaga 2760 ctgcagtgag ctgagatcac accactgtac tccagcctgg gtgacaaagt gagactctat 2820 ctcaaaaaga aattaggatc aacttgtcaa tttctacaac aacaacaaca aaaacccctg 2880 ttgggcacct tgattgagat tgcattgaat ttatataaaa ctgttgggag aattgacatc 2940 ttaataatat tgagtcttct ggcctataaa caaggtctgt cttcctaggt attaatgttt 3000 tgtcttctat ttctcttaat aatcttttgt agttttcagt gtacaggtct accatgtcag 3060 catttcatag ttttgatgct aaatggtatt ttaaaatttc aaattctaac cacttgttgc 3120 tagtaaatag aaatacaatt gatgttgaac ttgtatcctt cagccttgct aaactgtgag 3180 ttctcatggt gtttttgtaa attacatcaa cagtcatgtg ttctatgaat aaagagtttt 3240 actccttc 3248 <210> 99 <211> 1861 <212> DNA <213> Homo sapiens <400> 99 gggagcgcgg agcggaggcc gaggcgagag cctggcgctg taggactaga acgaaaggag 60 tgaggcgccg agagcccaga taccattttg gcgtgagagc tggtggttgg caaggccgcg 120 ggagtgggaa gcgtccgcca tgttctgcga aaaagccatg gaactgatcc gcgagctgca 180 tcgcgcgccc gaagggcaac tgcctgcctt caacgaggat ggactcagac aagttctgga 240 ggagatgaaa gctttgtatg aacaaaacca gtctgatgtg aatgaagcaa agtcaggtgg 300 acgaagtgat ttgataccaa ctatcaaatt tcgacactgt tctctgttaa gaaatcgacg 360 ctgcactgta gcatacctgt atgaccgctt gcttcggatc agagcactca gatgggaata 420 tggtagcatc ttgccaaatg cattacgatt tcacatggct gctgaagaaa tggagtggtt 480 taataattat aaaagatctc ttgctactta tatgaggtca ctgggaggag atgaaggttt 540 ggacattaca caggatatga aaccaccaaa aagcctatat attgaagtcc ggtgtctaaa 600 agactatgga gaatttgaag ttgatgatgg cacttcagtc ctattaaaaa aaaatagcca 660 gcacttttta cctcgatgga aatgtgagca gctgatcaga caaggagtcc tggagcacat 720 cctgtcatga ccatgcgccg aggcacttcc aggcttcact caactcatgg actcctctgt 780 actcactctc tccaccactc ccttcacctc cctctttgat tttagaagct atagacattg 840 tttaagataa ctaagaatac ttggctaaga agtataattt gctaactatt aaggactttc 900 tttttttaat gttgtacact attcttccta ctcttttttg gttttggttt tgttttgtag 960 agactgtctc actatgttgc ccaagctggt ctcaaactcc tggcctcaag cagtcctccc 1020 accttagctt ctcaaagtgt tgagatcaca ggcgtgagcc actgcacccg gcccctactc 1080 ctttttctaa taagctgtat ctgtaatcac agcattccta cagttgttac agtgtgtttt 1140 ttaaatgaaa gtaaacatgg ttacatttga atctcttaaa taagcagtca cttggctgga 1200 caggaagaag gtagatcctg tgtgtcttgt tttctggtca tgtgtattgt acaagctaga 1260 gagctgaatt tctgagatac acattttcaa atcacatgca agtgaagatg atggtctgta 1320 gaaattttca gtatatataa tgtttaatga catactaatt tatcatctgg ctatttggga 1380 aggaaggaca cacatggatt ttgcacattt ccaccatggt ggctggtgtg gcttgtggct 1440 atggggtgat caccagtatc accactttgg aaggggacag tgaaattggg gctagagaag 1500 gaactttgta cagttttccc tgagattcag attgactgaa aagtcacatg aagagttgat 1560 tgtcttttaa tggtatgttt taaacagctg acattttaaa ttttgatgaa atccagttta 1620 ttcgtttgtt cttttatgct ttgggtgttg catccgagaa atcttttccc atcccaagat 1680 cacaattttt tttccttttt acttctagaa gtgttataat tttaagcttt atactttggt 1740 ctatgacccg tttttttttt tgttttgttt tgttttttcg tttgtttctt tgttttgaga 1800 tggagcctgg gtgatagagt gagacactgt cttgccaaaa aaaaaaaaaa aaaaaaaaaa 1860 a 1861 <210> 100 <211> 1171 <212> DNA <213> Homo sapiens <400> 100 ccgggacgct gaggggcccg aggagaccgt gaggctctgg cctgcagctc gcgccgccat 60 ggacgctgcc gaggtcgaat tcctcgccga gaaggagctg gttaccatta tccccaactt 120 cagtctggac aagatctacc tcatcggggg ggacctgggg ccttttaacc ctggtttacc 180 cgtggaagtg cccctgtggc tggcgattaa cctgaaacaa agacagaaat gtcgcctgct 240 ccctccagag tggatggatg tagaaaagtt ggagaagatg agggatcatg aacgaaagga 300 agaaactttt accccaatgc ccagccctta ctacatggaa cttacgaagc tcctgttaaa 360 tcatgcttca gacaacatcc cgaaggcaga cgaaatccgg accctggtca aggatatgtg 420 ggacactcgt atagccaaac tccgagtgtc tgctgacagc tttgtgagac agcaggaggc 480 acatgccaag ctggataact tgaccttgat ggagatcaac accagcggga ctttcctcac 540 acaagcgctc aaccacatgt acaaactccg cacgaacctc cagcctctgg agagtactca 600 gtctcaggac ttctagagaa aggcctggtg caggcggctt gctgggggat gtgagcgctc 660 aggacgtgat gaggtactcg tggttctgga gctctagaaa cacttctgat gcatgaaaaa 720 tgtgtgatgg tgcaaggaat ggattcagga tgttgttgga gaaacaagtt tgtgattagt 780 ccttaaaact tagctccctg ggacattctt caattccaca tctgtttcta gaaaccagcc 840 ctttttcccc ccacttttga gaaataaaaa agccttaggt aaataagtca ttctccctag 900 cagagccact tgggtctcct gcatggaagc cgtcacactt gggcaggtgt tcagtgactg 960 gtaggtgtag atacagcagg agtggccatg tggtccacgg ctttttaccc cttcttgatc 1020 ctgatttctt gggctgaatt tagactctct cacagaggtg gctcacagag aaggatggca 1080 gatggtgcag ccaacaatgc tgaccggtgc ttatcctcta agccctgatc cacaataaaa 1140 atggacccaa ctcaaaaaaa aaaaaaaaaa a 1171 <210> 101 <211> 1182 <212> DNA <213> Homo sapiens <400> 101 gcggccggcg gcgtctcctc ccgggacgct gaggggcccg aggagaccgt gaggctctgg 60 cctgcagctc gcgccgccat ggacgctgcc gaggtcgaat tcctcgccga gaaggagctg 120 gttaccatta tccccaactt cagtctggac aagatctacc tcatcggggg ggacctgggg 180 ccttttaacc ctggtttacc cgtggaagtg cccctgtggc tggcgattaa cctgaaacaa 240 agacagaaat gtcgcctgct ccctccagag tggatggatg tagaaaagtt ggagaagatg 300 agggatcatg aacgaaagga agaaactttt accccaatgc ccagccctta ctacatggaa 360 cttacgaagc tcctgttaaa tcatgcttca gacaacatcc cgaaggcaga cgaaatccgg 420 accctggtca aggatatgtg ggacactcgt atagccaaac tccgagtgtc tgctgacagc 480 tttgtgagac agcaggaggc acatgccaag ctggataact tgaccttgat ggagatcaac 540 accagcggga ctttcctcac acaagcgctc aaccacatgt acaaactccg cacgaacctc 600 cagcctctgg agagtactca gtctcaggac ttctagagaa aggcctggtg caggcggctt 660 gctgggggat gtgagcgctc aggatgtgat gaggtactcg tggttctgga gctctagaaa 720 cacttctgat gcatgaaaaa tgtgtgatgg tgcaaggaat ggattcagga tgttgttgga 780 gaaacaagtt tgtgattagt ccttaaaact tagctccctg ggacattctt caattccaca 840 tctgtttcta gaaaccagcc ctttttcccc ccacttttga gaaataaaaa agccttaggt 900 aaataagtca ttctccctag cagagccact tgggtctcct gcatggaagc cgtcacactt 960 gggcaggtgt tcagtgactg gtaggtgtag atacagcagg agtggccatg tggtccacgg 1020 ctttttaccc cttcttgatc ctgatttctt gggctgaatt tagactctct cacagaggtg 1080 gctcacagag aaggatggca gatggtgcag ccaacaatgc tgaccggtgc ttatcctcta 1140 agccctgatc cacaataaaa atggacccaa ctcaaaaaaa aa 1182 <210> 102 <211> 1174 <212> DNA <213> Homo sapiens <400> 102 gcggccgcgg cgtctcctcc gggacgctga ggggcccgag gagaccgtga ggctctggcc 60 tgcagctcgc gccgccatgg acgctgccga ggtcgaattc ctcgccgaga aggagctggt 120 taccattatc cccaacttca gtctggacaa gatctacctc atcggggggg acctggggcc 180 ttttaaccct ggtttacccg tggaagtgcc cctgtggctg gcgattaacc tgaaacaaag 240 acagaaatgt cgcctgctcc ctccagagtg gatggatgta gaaaagttgg agaagatgag 300 ggatcatgaa cgaaaggaag aaacttttac cccaatgccc agcccttact acatggaact 360 tacgaagctc ctgttaaatc atgcttcaga caacatcccg aaggcagacg aaatccggac 420 cctggtcaag gatatgtggg acactcgtat agccaaactc cgagtgtctg ctgacagctt 480 tgtgagacag caggaggcac atgccaagct ggataacttg accttgatgg agatcaacac 540 cagcgggact ttcctcacac aagcgctcaa ccacatgtac aaactccgca cgaacctcca 600 gcctctggag agtactcagt ctcaggactt ctagagaaag gcctggtgca ggcggcttgc 660 tgggggatgt gagcgctcag gacgtgatga ggtactcgtg gttctggagc tctagaaaca 720 cttctgatgc atgaaaaatg tgtgatggtg caaggaatgg attcaggatg ttgttggaga 780 aacaagtttg tgattagtcc ttaaaactta gctccctggg acattcttca attccacatc 840 tgtttctaga aaccagccct ttttcccccc acttttgaga aataaaaaag ccttaggtaa 900 ataagtcatt ctccctagca gagccacttg ggtctcctgc atggaagcca tcacacttgg 960 gcaggtgttc agtgactggt aggtgtagat acagcaggag tggccatgtg gtccacggct 1020 ttttacccct tcttgatcct catttcttgg gctgaattta gactctctca cagaggtggc 1080 tcacagagaa ggatggcaga tggtgcagcc aacaatgctg accggtgctt atcctctaag 1140 ccctgatcca caataaaaat ggacccaact caaa 1174 <210> 103 <211> 1182 <212> DNA <213> Homo sapiens <400> 103 gcggccggcg gcgtctcctc ccgggacgct gaggggcccg aggagaccgt gaggctctgg 60 cctgcagctc gcgccgccat ggacgctgcc gaggtcgaat tcctcgccga gaaggagctg 120 gttaccatta tccccaactt cagtctggac aagatctacc tcatcggggg ggacctgggg 180 ccttttaacc ctggtttacc cgtggaagtg cccctgtggc tggcgattaa cctgaaacaa 240 agacagaaat gtcgcctgct ccctccagag tggatggatg tagaaaagtt ggagaagatg 300 agggatcatg aacgaaagga agaaactttt accccaatgc ccagccctta ctacatggaa 360 cttacgaagc tcctgttaaa tcatgcttca gacaacatcc cgaaggcaga cgaaatccgg 420 accctggtca aggatatgtg ggacactcgt atagccaaac tccgagtgtc tgctgacagc 480 tttgtgagac agcaggaggc acatgccaag ctggataact tgaccttgat ggagatcaac 540 accagcggga ctttcctcac acaagcgctc aaccacatgt acaaactccg cacgaacctc 600 cagcctctgg agagtactca gtctcaggac ttctagagaa aggcctggtg caggcggctt 660 gctgggggat gtgagcgctc aggatgtgat gaggtactcg tggttctgga gctctagaaa 720 cacttctgat gcatgaaaaa tgtgtgatgg tgcaaggaat ggattcagga tgttgttgga 780 gaaacaagtt tgtgattagt ccttaaaact tagctccctg ggacattctt caattccaca 840 tctgtttcta gaaaccagcc ctttttcccc ccacttttga gaaataaaaa agccttaggt 900 aaataagtca ttctccctag cagagccact tgggtctcct gcatggaagc cgtcacactt 960 gggcaggtgt tcagtgactg gtaggtgtag atacagcagg agtggccatg tggtccacgg 1020 ctttttaccc cttcttgatc ctgatttctt gggctgaatt tagactctct cacagaggtg 1080 gctcacagag aaggatggca gatggtgcag ccaacaatgc tgaccggtgc ttatcctcta 1140 agccctgatc cacaataaaa atggacccaa ctcaaaaaaa aa 1182 <210> 104 <211> 858 <212> DNA <213> Homo sapiens <400> 104 gagaccgtga ggctctggcc tgcagctcgc gccgccatgg acgctgccga ggtcgaattc 60 ctcgccgaga aggagctggt taccattatc cccaacttca gtctggacaa gatctacctc 120 atcggggggg acctggggcc ttttaaccct ggtttacccg tggaagtgcc cctgtggctg 180 gcgattaacc tgaaacaaag acagaaatgt cgcctgctcc ctccagagtg gatggatgta 240 gaaaagttgg agaagatgag ggatcatgaa cgaaaggaag aaacttttac cccaatgccc 300 agcccttact acatggaact tacgaagctc ctgttaaatc atgcttcaga caacatcccg 360 aaggcagacg aaatccggac cctggtcaag gatatgtggg acactcgtat agccaaactc 420 cgagtgtctg ctgacagctt tgtgagacag caggaggcac atgccaagct ggataacttg 480 accttgatgg agatcaacac cagcgggact ttcctcacac aagcgctcaa ccacatgtac 540 aaactccgca cgaacctcca gcctctggag agtactcagt ctcaggactt ctagagaaag 600 gcctggtgca ggcggcttgc tgggggatgt gagcgctcag gacgtgatga ggtactcgtg 660 gttctggagc tctagaaaca cttctgatgc atgaaaaatg tgtgatggtg caaggaatgg 720 attcaggatg ttgttggaga aacaagtttg tgattagtcc ttaaaactta gctccctggg 780 acattcttca attccacatc tgtttctaga aaccagccct ttttcccccc acttttgaga 840 aataaaaaag ccttaggt 858 <210> 105 <211> 1188 <212> DNA <213> Homo sapiens <400> 105 gcggccgcgg cgtctcctcc cggacgctga ggggcccgag gagaccgtga ggctctggcc 60 tgcagctcgc gccgccatgg acgctgccga ggtcgaattc ctcgccgaga aggagctggt 120 taccattatc cccaacttca gtctggacaa gatctacctc atcggggggg acctggggcc 180 ttttaaccct ggtttacccg tggaagtgcc cctgtggctg gcgattaacc tgaaacaaag 240 acagaaatgt cgcctgctcc ctccagagtg gatggatgta gaaaagttgg agaagatgag 300 ggatcatgaa cgaaaggaag aaacttttac cccaatgccc agcccttact acatggaact 360 tacgaagctc ctgttaaatc atgcttcaga caacatcccg aaggcagacg aaatccggac 420 cctggtcaag gatatgtggg acactcgtat agccaaactc cgagtgtctg ctgacagctt 480 tgtgagacag caggaggcac atgccaagct ggataacttg accttgatgg agatcaacac 540 cagcgggact ttcctcacac aagcgctcaa ccacatgtac aaactccgca cgaacctcca 600 gcctctggag agtactcagt ctcaggactt ctagagaaag gcctggtgca ggcggcttgc 660 tgggggatgt gagcgctcag gacgtgatga ggtactcgtg gttctggagc tctagaaaca 720 cttctgatgc atgaaaaatg tgtgatggtg caaggaatgg attcaggatg ttgttggaga 780 aacaagtttg tgattagtcc ttaaaactta gctccctggg acattcttca attccacatc 840 tgtttctaga aaccagccct ttttcccccc acttttgaga aataaaaaag ccttaggtaa 900 ataagtcatt ctccctagca gagccacttg ggtctcctgc atggaagcca tcacacttgg 960 gcaggtgttc agtgactggt aggtgtagat acagcaggag tggccatgtg gtccacggct 1020 ttttacccct tcttgatcct gatttcttgg gctgaattta gactctctca cagaggtggc 1080 tcacagagaa ggatggcaga tggtgcagcc aacaatgctg accggtgctt atcctctaag 1140 ccctgatcca caataaaaat ggacccaact caaaaaaaaa aaaaaaaa 1188 <210> 106 <211> 891 <212> DNA <213> Homo sapiens <400> 106 aggggcccga ggagaccgtg aggctctggc ctgcagctcg cgccgccatg gacgctgccg 60 aggtcgaatt cctcgccgag aaggagctgg ttaccattat ccccaacttc agtctggaca 120 agatctacct catcgggggg gacctggggc cttttaaccc tggtttaccc gtggaagtgc 180 ccctgtggct ggcgattaac ctgaaacaaa gacagaaatg tcgcctgctc cctccagagt 240 ggatggatgt agaaaagttg gagaagatga gggatcatga acgaaaggaa gaaactttta 300 ccccaatgcc cagcccttac tacatggaac ttacgaagct cctgttaaat catgcttcag 360 acaacatccc gaaggcagac gaaatccgga ccctggtcaa ggatatgtgg gacactcgta 420 tagccaaact ccgagtgtct gctgacagct ttgtgagaca gcaggaggca catgccaagc 480 tggataactt gaccttgatg gagatcaaca ccagcgggac tttcctcaca caagcgctca 540 accacatgta caaactccgc acaaacctcc agcctctgga gagtactcag tctcaggact 600 tctagagaaa ggcctggtgc aggcggcttg ctgggggatg tgagcgctca ggacgtgatg 660 aggtactcgt ggttctggag ctctagaaac acttctgatg catgaaaaat gtgtgatggt 720 gcaaggaatg gattcaggat gttgttggag aaacaagttt gtgattagtc cttaaaactt 780 agctccctgg gacattcttc aattccacat ctgtttctag aaaccagccc tttttccccc 840 cacttttgag aaataaaaaa gccttaggta aataaaaaaa aaaaaaaaaa a 891 <210> 107 <211> 1203 <212> DNA <213> Homo sapiens <400> 107 ggaaaacggc ggccgcggcg tctcctccgg gacgctgagg ggcccgagga gaccgtgagg 60 ctctggcctg cagctcgcgc cgccatggac gctgccgagg tcgaattcct cgccgagaag 120 gagctggtta ccattatccc caacttcagt ctggacaaga tctacctcat cgggggggac 180 ctggggcctt ttaaccctgg tttacccgtg gaagtgcccc tgtggctggc gattaacctg 240 aaacaaagac agaaatgtcg cctgctccct ccagagtgga tggatgtaga aaagttggag 300 aagatgaggg atcatgaacg aaaggaagaa acttttaccc caatgcccag cccttactac 360 atggaactta cgaagctcct gttaaatcat gcttcagaca acatcccgaa ggcagacgaa 420 atccggaccc tggtcaagga tatgtgggac actcgtatag ccaaactccg agtgtctgct 480 gacagctttg tgagacagca ggaggcacat gccaagctgg ataacttgac cttgatggag 540 atcaacacca gcgggacttt cctcacacaa gcgctcaacc acatgtacaa actccgcaca 600 aacctccagc ctctggagag tactcagtct caggacttct agagaaaggc ctggtgcagg 660 cggcttgctg ggggatgtga gcgctcagga cgtgatgagg tactcgtggt tctggagctc 720 tagaaacact tctgatgcat gaaaaatgtg tgatggtgca aggaatggat tcaggatgtt 780 gttggagaaa caagtttgtg attagtcctt aaaacttagc tccctgggac attcttcaat 840 tccacatctg tttctagaaa ccagcccttt ttccccccac ttttgagaaa taaaaaagcc 900 ttaggtaaat aagtcattct ccctagcaga gccacttggg tctcctgcat ggaagccatc 960 acacttgggc aggtgttcag tgactggtag gtgtagatac agcaggagtg gccatgtggt 1020 ccacggcttt ttaccccttc ttgatcctca tttcttgggc tgaatttaga ctctctcaca 1080 gaggtggctc acagagaagg atggcagatg gtgcagccaa caatgctgac cggtgcttat 1140 cctctaagcc ctgatccaca ataaaaatgg acccaactca aaaaaaaaaa aaaaaaaaaa 1200 aaa 1203 <210> 108 <211> 1183 <212> DNA <213> Homo sapiens <400> 108 gggggacgct gaggggcccg aggagaccgt gaggctctgg cctgcagctc gcgccgccat 60 ggacgctgcc gaggtcgaat tcctcgccga gaaggagctg gttaccatta tccccaactt 120 cagtctggac aagatctacc tcatcggggg ggacctgggg ccttttaacc ctggtttacc 180 cgtggaagtg cccctgtggc tggcgattaa cctgaaacaa agacagaaat gtcgcctgct 240 ccctccagag tggatggatg tagaaaagtt ggagaagatg agggatcatg aacgaaagga 300 agaaactttt accccaatgc ccagccctta ctacatggaa cttacgaagc tcctgttaaa 360 tcatgcttca gacaacatcc cgaaggcaga cgaaatccgg accctggtca aggatatgtg 420 ggacactcgt atagccaaac tccgagtgtc tgctgacagc tttgtgagac agcaggaggc 480 acatgccaag ctggataact tgaccttgat ggagatcaac accagcggga ctttcctcac 540 acaagcgctc aaccacatgt acaaactccg cacaaatctc cagcctctgg agagtactca 600 gtctcaggac ttctagagaa aggcctggtg caggcggctt gctgggggat gtgagcgctc 660 aggacgtgat gaggtactcg tggttctgga gctctagaaa cacttctgat gcatgaaaaa 720 tgtgtgatgg tgcaaggaat ggattcagga tgttgttgga gaaacaagtt tgtgattagt 780 ccttaaaact tagctccctg ggacattctt caattccaca tctgtttcta gaaaccagcc 840 ctttttcccc ccacttttga gaaataaaaa agccttaggt aaataagtca ttctccctag 900 cagagccact tgggtctcct gcatggaagc catcacactt gggcaggtgt tcagtgactg 960 gtaggtgtag atacagcagg agtggccatg tggtccacgg ctttttaccc cttcttgatc 1020 ctcatttctt gggctgaatt tagactctct cacagaggtg gctcacagag aaggatggca 1080 gatggtgcag ccaacaatgc tgaccggtgc ttatcctcta agccctgatc cacaataaaa 1140 atggacccaa cgcaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa 1183 <210> 109 <211> 3097 <212> DNA <213> Homo sapiens <400> 109 gaccgtgagg ctctggcctg cagctcgcgc cgccatggac gctgccgagg tcgaattcct 60 cgccgagaag gagctggtta ccattatccc caacttcagt ctggacaaga tctacctcat 120 cgggggggac ctggggcctt ttaaccctgg tttacccgtg gaagtgcccc tgtggctggc 180 gattaacctg aaacaaagac agaaatgtcg cctgctccct ccagagtgga tggatgtaga 240 aaagttggag aagatgaggg atcatgaacg aaaggaagaa acttttaccc caatgcccag 300 cccttactac atggaactta cgaagctcct gttaaatcag taagtagatc tcacctctta 360 gaggccacac ccaagactgg actcgccatg cccttcccct aaccctagtc cttcctctcc 420 gcttccctgc ttattgcctc agtaagtggc aacactggcc gccctgtttc tcaggtcagt 480 gaccatgagg tcatctgtgt acacacacct gccaggtgca ctctgtctgt ctctgtgtgt 540 ctttctgtct gttctttgcc tttctctgtc tctcattttt ccttttctcc acttcccggt 600 gaagcccttg gctctttttg ttctgcctca catcactcga cattggaccc cagtgtgagc 660 caccagcatc tcacagaatc ggcagtagcc attctttgcc atgtatgtgt tttatttagc 720 acagctttac tcctgtttct ccttggagta ggtggatttg agtttttttg tgtctttcgc 780 aggaaaggcc agagggcttg tgcttaggct gagatgaggc tgcagtcagc ccatgaattt 840 cataaaaagc tgagaagcag caatgcacca agcattccac tcggcagtgg cgtttgtccc 900 ataggcctgc ttcctggtgt ggtgcgggag agatgtgggc ctgggagcct atagtgaatc 960 ttcagtgtga ccaatgctct tgacagtcca tcagagcgca gtaaggccag gtggtgccag 1020 agagggctca cagaggtttg ctgggagtgc agacttgtag gaggtggacg gtaggggaga 1080 gggcagtgag gcaggaactg atatgctcag gcagagtgtg aaggacctgg tgtagccggg 1140 caagcagaga tatttgagga tgtgtagtac attcatggga gcagaggaat ggaggcatag 1200 gttctgctgc agtggccagc ccctgggagg ggcatgtggc ctcagaggga cctgagagag 1260 actgtagtgg tggtggggat ggtagctgga agggagagga tctataaaca ggctaggtaa 1320 gaatttggca ttagctaggt gagggggcct atccattttt tgtttttgaa gttcaatata 1380 ttatggatgt agtttttatc aaaaaccttg ttttataatt cattcggtta agggacttaa 1440 ttttacgttt gttctatagt tcagttgacg aggagttggg gtcctttgtc ctttaacctg 1500 ctgttcagag cacaagatct aaatgtttgg gtttataaat aaaactcact acataaattt 1560 tgtaccagtg gtttgccact tactcatcag gaattaattg tagcatatgg agagaatgtc 1620 tagcgtaacc tgtaatgcct agtgacgaac aatatttgct tctgctttta tcgtgtagtt 1680 tttcttcaaa ggttagttta aaatacttca caacgggagc ctcgactttg tgaaagcctt 1740 ccttcatccc ttgctggctt tgagcttcta gccagaattt tgctatgtgt aggtgtgctc 1800 actgtatact aatttgcagt ttcttctgtg atttttgaaa cttgtttttg tcttctctga 1860 agagcaggag agtcccttcc cttcagggct tttgtgagga tagaaatgcc aggtaaagtg 1920 ctgagcccag tacctggcat ggagttggcg ttttccttct ctaggctgtg agccctggat 1980 tcctggtggg gaatagggag acctgctcaa cactctgtaa atgaggagca atagaactcg 2040 acctttgagc cagccctcga aactgattcc ttgtagatgg aggttaggca gcacggaatg 2100 ctgttatcct gagacagagg cttctgactt agagctgatt ctctactaat tttcttaggt 2160 aaacagcagt cctgttcagc agcctgccat gggatagtta atgtgagcaa aagaaactcc 2220 atgtggatca ctgccgcacc aagcttaact gctacaaatc tttacaccct aaagttgaaa 2280 ataaagcaaa acagactttc tgagtctgga atagccacgg tattttgcct gaaaagagcc 2340 actctatcca gcattgcctc aggttatcaa gtgttccccg actgacttta gcccttgctc 2400 ctttagtgct tcagacaaca tcccgaaggc agacgaaatc cggactctgg tcaaggatat 2460 gtgggacact cgtatagcca aactccgagt gtctgctgac agctttgtga gacagcagga 2520 ggcacatgcc aaggtaggtg ccgccttgcc tgggtgctgg tggccttgat gccgcataat 2580 ttcacatggc tcccgtctgc tgaggctatt acaggcaggc attactagct gtgcttttca 2640 acagttcatt ggtttcttat ttttattcag tagagtttac ctttttctca aaatcaaaaa 2700 ctccttggcc aacttggtct gttttcttgc tttagctgga taacttgacc ttgatggaga 2760 tcaacaccag cgggactttc ctcacacaag cgctcaacca catgtacaaa ctccgcacga 2820 acctccagcc tctggagagt actcagtctc aggacttcta gagaaaggcc tggtgcaggc 2880 ggcttgctgg gggatgtgag cgctcaggat gtgatgaggt actcgtggtt ctggagctct 2940 agaaacactt ctgatgcatg aaaaatgtgt gatggtgcaa ggaatggatt caggatgttg 3000 ttggagaaac aagtttgtga ttagtcctta aaacttagct ccctgggaca ttcttcaatt 3060 ccacatctgt ttctagaaac cagccctttt tcccccc 3097 <210> 110 <211> 2176 <212> DNA <213> Homo sapiens <400> 110 ccgcttcccc gtcttgtaca cccctaactc ctgaggctcc tccgaatcac gcgagtggaa 60 gcggagaagc tcaagtggcc gccatgtcag aggcttattt ccgagtggag tcgggtgcgc 120 tggggcctga ggagaacttt ctttctttgg acgacatcct gatgtcccac gagaagctgc 180 cggtgcgcac ggagaccgcc atgcctcgcc ttggcgcttt cttcctggag cggagcgcag 240 gcgccgagac tgacaacgcg gtcccacagg gttccaagct tgaactaccc ttgtggctgg 300 caaaaggact ttttgacaac aagcgacgga tcctttctgt ggaactcccc aagatctacc 360 aagagggttg gaggactgtg ttcagtgcag atcccaatgt ggtggacctc cacaaaatgg 420 ggccccattt ctacgggttt ggctcccagc tcctgcattt tgacagtccc gagaatgcag 480 acatttccca gtctctgctg cagactttta tcggacgttt tcgccgcatc atggactcct 540 cacagaatgc ttacaacgaa gacacttcag ccctggtagc caggctagac gagatggaga 600 ggggcttatt tcaaacaggg cagaaaggac tgaatgactt tcagtgttgg gagaaggggc 660 aggcttctca gatcacagct tccaacctcg ttcagaatta caagaagaga aaattcactg 720 atatggaaga ctgaaagccg gaagaacaca gaatggctcc tcacagacgt atccctccgt 780 gtgtccttga taggagctgg ttgaccttgt acagaaccag aatcctgtcc catttcatgg 840 cttatttcct gtggccatag agaattatag ggaactggac atgctggagg atgtgggtgt 900 ccctggctct gtgagtcttc caggaccgtc ccaccctgct gacccacagc ccaggccctt 960 taacccaaga acccatggcc aaggagaaat caaagtcctt cctaaataag aatcactgcc 1020 atataatata tcacagtaga gttgcaactg agattccttg tgtctgggag tttggacagc 1080 ttcagatgta cagtttcact agccacaaag cacaggtaca aactgggtca tcgcctgttc 1140 acaaaatgct ctcttgatct tatttgcctc atcttcctca tggttgtaca gaggatagca 1200 ccccaccatg ccagcctgac ttggagatat ctcctgctgc ctgcctgcag ggagttaccc 1260 cagtttccaa aaacagtcgc ccagataaag gaggaaaagg gaaaggcaga cgaatggcat 1320 ggcttttact aaagaaaaga tgttggcctc atactctata ctcagggctt aatgaactgg 1380 aatctgcata actcagcagt caacccagaa gggaaatggt taaactgagc ttgttattgc 1440 ctcggagagc ctaagagcac ccgcacactt aattctactc cctgtctaga aaagctgtca 1500 gggagtcgtt tggaattgca atgtagttat taagggctgt taaccagcct gcattacatc 1560 tggaagtcag gacttgggtg ctgactatga agggccctgt tttcaaaatc taacattgca 1620 agtgtaaatg ggcaagaagc ctccgttgtg cttttttttt cctcttcagt aacttttgca 1680 acattattgc atagaagatc cctgaccatt tactaggaac ctggttaagc aagcactaat 1740 ctcttttcct ggagatcaag gatgcaacct caggttgaga aagaaacagg gttccctggg 1800 cccattagac tgtttgcagg gcatcactgc ttccccctga cacctcacaa ctagcaaaaa 1860 ttgtctttgt ctttggaaat tatagaggga tttgggtatc cagattgtgc agatgcaaac 1920 ttaggctgtc ttgatgcaaa cttagaacca cagaaatgct tttaaaatgc ctgttttaag 1980 atggaattgt tgtttttata atttgatttt agtgctaaat aaatgattgg ctttgtacat 2040 gaatatgttc tgtacaagtg ctctttcact agtactacag ataatcaaag ctatcagaat 2100 tgtgtctttg atcatatttg acggtaatac acaaataaat ccatgtttta gcaaaaaaaa 2160 aaaaaaaaaa aaaaaa 2176 <210> 111 <211> 2079 <212> DNA <213> Homo sapiens <400> 111 caaccatcct gcccagtctc cgcttccccg tcttgtacac ccctaactcc tgaggctcct 60 ccgaatcacg cgagtggaag cggagaagct caagtggccg ccatgtcaga ggcttatttc 120 cgagtggagt cgggtgcgct ggggcctgag gagaactttc tttctttgga cgacatcctg 180 atgtcccacg agaagctgcc ggtgcgcacg gagaccgcca tgcctcgcct tggcgctttc 240 ttcctggagc ggagcgcagg cgccgagact gacaacgcgg tcccacaggg ttccaagctt 300 gaactaccct tgtggctggc aaaaggactt tttgacaaca agcgacggat cctttctgtg 360 gaactcccca agatctacca agagggttgg aggactgtgt tcagtgcaga tcccaatgtg 420 gtggacctcc acaaaatggg gccccatttc tacgggtttg gctcccagct cctgcatttt 480 gacagtcccg agaatgcaga catttcccag tctctgctgc agacttttat cggacgtttt 540 cgccgcatca tggactcctc acagaatgct tacaacgaag acacttcagc cctggtagcc 600 aggctagacg agatggagag gggcttattt caaacagggc agaaaggact gaatgacttt 660 cagtgttggg agaaggggca ggcttctcag atcacagctt ccaacctcgt tcagaattac 720 aagaagagaa aattcactga tatggaagac tgaaagccgg aagaacacag aatggctcct 780 cacagacgta tccctccgtg tgtccttgat aggagctggt tgaccttgta cagaaccaga 840 atcctgtccc atttcatggc ttatttcctg tggccataga gaattatagg gaactggaca 900 tgctggagga tgtgggtgtc cctggctctg tgagtcttcc aggaccgtcc caccctgctg 960 acccacagcc caggcccttt aacccaagaa cccatggcca aggagaaatc aaagtccttc 1020 ctaaataaga atcactgcca tataatatat cacagtagag ttgcaactga gattccttgt 1080 gtctgggagt ttggacagct tcagatgtac agtttcacta gccacaaagc acaggtacaa 1140 actgggtcat cgcctgttca caaaatgctc tcttgatctt atttgcctca tcttcctcat 1200 ggttgtacag aggatagcac cccaccatgc cagcctgact tggagatatc tcctgctgcc 1260 tgcctgcagg gagttacccc agtttccaaa aacagtcgcc cagataaagg aggaaaaggg 1320 aaaggcagac gaatggcatg gcttttacta aagaaaagat gttggcctca tactctatac 1380 tcagggctta atgaactgga atctgcataa ctcagcagtc aacccagaag ggaaatggtt 1440 aaactgagct tgttattgcc tcggagagcc taagagcacc cgcacactta attctactcc 1500 ctgtctagaa aagctgtcag ggagtcgttt ggaattgcaa tgtagttatt aagggctgtt 1560 aaccagcctg cattacatct ggaagtcagg acttgggtgc tgactatgaa gggccctgtt 1620 ttcaaaatct aacattgcaa gtgtaaatgg gcaagaagcc tccgttgtgc tttttttttc 1680 ctcttcagta acttttgcaa cattattgca tagaagatcc ctgaccattt actaggaacc 1740 tggttaagca agcactaatc tcttttcctg gagatcaagg atgcaacctc aggttgagaa 1800 agaaacaggg ttccctgggc ccattagact gtttgcaggg catcactgct tccccctgac 1860 acctcacaac tagcaaaaat tgtctttgtc tttggaaatt atagagggat ttgggtatcc 1920 agattgtgca gatgcaaact taggctgtct tgatgcaaac ttagaaccac agaaatgctt 1980 ttaaaatgcc tgttttaaga tggaattgtt gtttttataa tttgatttta gtgctaaata 2040 aatgattggc tttgtacatg aaaaaaaaaa aaaaaaaaa 2079 <210> 112 <211> 2176 <212> DNA <213> Homo sapiens <400> 112 ccgcttcccc gtcttgtaca cccctaactc ctgaggctcc tccgaatcac gcgagtggaa 60 gcggagaagc tcaagtggcc gccatgtcag aggcttattt ccgagtggag tcgggtgcgc 120 tggggcctga ggagaacttt ctttctttgg acgacatcct gatgtcccac gagaagctgc 180 cggtgcgcac ggagaccgcc atgcctcgcc ttggcgcttt cttcctggag cggagcgcag 240 gcgccgagac tgacaacgcg gtcccacagg gttccaagct tgaactaccc ttgtggctgg 300 caaaaggact ttttgacaac aagcgacgga tcctttctgt ggaactcccc aagatctacc 360 aagagggttg gaggactgtg ttcagtgcag atcccaatgt ggtggacctc cacaaaatgg 420 ggccccattt ctacgggttt ggctcccagc tcctgcattt tgacagtccc gagaatgcag 480 acatttccca gtctctgctg cagactttta tcggacgttt tcgccgcatc atggactcct 540 cacagaatgc ttacaacgaa gacacttcag ccctggtagc caggctagac gagatggaga 600 ggggcttatt tcaaacaggg cagaaaggac tgaatgactt tcagtgttgg gagaaggggc 660 aggcttctca gatcacagct tccaacctcg ttcagaatta caagaagaga aaattcactg 720 atatggaaga ctgaaagccg gaagaacaca gaatggctcc tcacagacgt atccctccgt 780 gtgtccttga taggagctgg ttgaccttgt acagaaccag aatcctgtcc catttcatgg 840 cttatttcct gtggccatag agaattatag ggaactggac atgctggagg atgtgggtgt 900 ccctggctct gtgagtcttc caggaccgtc ccaccctgct gacccacagc ccaggccctt 960 taacccaaga acccatggcc aaggagaaat caaagtcctt cctaaataag aatcactgcc 1020 atataatata tcacagtaga gttgcaactg agattccttg tgtctgggag tttggacagc 1080 ttcagatgta cagtttcact agccacaaag cacaggtaca aactgggtca tcgcctgttc 1140 acaaaatgct ctcttgatct tatttgcctc atcttcctca tggttgtaca gaggatagca 1200 ccccaccatg ccagcctgac ttggagatat ctcctgctgc ctgcctgcag ggagttaccc 1260 cagtttccaa aaacagtcgc ccagataaag gaggaaaagg gaaaggcaga cgaatggcat 1320 ggcttttact aaagaaaaga tgttggcctc atactctata ctcagggctt aatgaactgg 1380 aatctgcata actcagcagt caacccagaa gggaaatggt taaactgagc ttgttattgc 1440 ctcggagagc ctaagagcac ccgcacactt aattctactc cctgtctaga aaagctgtca 1500 gggagtcgtt tggaattgca atgtagttat taagggctgt taaccagcct gcattacatc 1560 tggaagtcag gacttgggtg ctgactatga agggccctgt tttcaaaatc taacattgca 1620 agtgtaaatg ggcaagaagc ctccgttgtg cttttttttt cctcttcagt aacttttgca 1680 acattattgc atagaagatc cctgaccatt tactaggaac ctggttaagc aagcactaat 1740 ctcttttcct ggagatcaag gatgcaacct caggttgaga aagaaacagg gttccctggg 1800 cccattagac tgtttgcagg gcatcactgc ttccccctga cacctcacaa ctagcaaaaa 1860 ttgtctttgt ctttggaaat tatagaggga tttgggtatc cagattgtgc agatgcaaac 1920 ttaggctgtc ttgatgcaaa cttagaacca cagaaatgct tttaaaatgc ctgttttaag 1980 atggaattgt tgtttttata atttgatttt agtgctaaat aaatgattgg ctttgtacat 2040 gaatatgttc tgtacaagtg ctctttcact agtactacag ataatcaaag ctatcagaat 2100 tgtgtctttg atcatatttg acggtaatac acaaataaat ccatgtttta gcaaaaaaaa 2160 aaaaaaaaaa aaaaaa 2176 <210> 113 <211> 3205 <212> DNA <213> Homo sapiens <400> 113 cattgcttcg agtcacgacc aggtcttctg tgcttgacag ccactccccc aaagagaaaa 60 ggcagtattg cgcaggcgat gtgtatttcc ttttcgtcac acacatttgc tgtgttactt 120 gtctgttttt aaaatctaca ttcatgcatg ctgcagggtt ccaagcttga actacccttg 180 tggctggcaa aaggactttt tgacaacaag cgacggatcc tttctgtgga actccccaag 240 atctaccaag agggttggag gactgtgttc agtgcagatc ccaatgtggt ggacctccac 300 aaaatggggc cccatttcta cgggtttggc tcccagctcc tgcattttga cagtcccgag 360 aatgcagaca tttcccagtc tctgctgcag gcaagtaatg ggtgtgaaaa cctgtggtgc 420 tgcacttgtc tcaagagcca gccacagata ctacttttac ccaggacagt gtatgacttg 480 taaatttagt ctgtttttat tccaggtcag cctacagtta cactgtctgt ccattttata 540 tatttacata tatacacaca cacacacaca cacacacaca tttttttaat atgacttgtc 600 tgccactcct catatttgct tgctacaagt tgaggccagc aggaactcta ggaaatgaga 660 aaagggtgat gatggccagg catggtggct cacacctgta atcccagcac tttgggaggc 720 caaggcagga ggatcgctga gcccaggagt tcaagaccaa cctgggcaac atagtgagat 780 cccatctcta ttaaaaagaa aaaagagaaa aaaagggcta tggtgcatta caggtgacag 840 gcacttagat acacagtccc aggcctggcc taagggttcc tgttggaaat acaagagtta 900 ttgggttgtt tccttccttt gttctggggt tagggcttgg ccctgccatg aactagcaat 960 atgacttggt caagctactt gacctctcta gacatcaatt cacctgtaag aattgatgga 1020 gatgataata gtgccaaaat tatagagttg tggtaaaact atgtaatgcc gtgtaataaa 1080 caataactca tattgttatt acttttccag gacaaaacaa tgttatacat ctgttcccaa 1140 cctttatggt ataaccttat tttaattttt cataattact tttttattct gttactgtta 1200 gaagaaacca tcatttcttc ctcttgggac agaagcattt gctactaatg acaataatag 1260 gtgatgcttc tcaaggagct tgctgtgtgc tagccatttg ctaggtgcat tacatgtatt 1320 cattggtttt cttaacaact tactggattt tcataacaat ccacttcaca gatgaggaaa 1380 ttgaggcatg gcaatgtgca ataacttact tgggtgctag agggaattca gacctccttc 1440 tgagtcctac acatcattct ttcttttcat gccatttaaa tgttctgaga taaaaatgga 1500 tatgactttg tggggtgtga ggtcaaccct gacttgtctt actcccttgt ttcccagact 1560 tttatcggac gttttcgccg catcatggac tcctcacaga atgcttacaa cgaagacact 1620 tcagccctgg tagccaggct agacgagatg gagaggggct tatttcaaac agggcagaaa 1680 ggactgaatg actttcagtg ttgggagaag gggcaggctt ctcagatcac agcttccaac 1740 ctcgttcaga attacaagaa gagaaaattc actgatatgg aagactgaaa gccggaagaa 1800 cacagaatgg ctcctcacag acgtatccct ccgtgtgtcc ttgataggag ctggttgacc 1860 ttgtacagaa ccagaatcct gtcccatttc atggcttatt tcctgtggcc atagagagtt 1920 atagggaact ggacatgctg gaggatgtgg gtgtccctgg ctctgtgagt cttccaggac 1980 cgtcccaccc tgctgaccca cagcccaggc cctttaaccc aagaacccat ggccaaggag 2040 aaatcaaagt ccttcctaaa taagaatcac tgccatataa tatatcacag tagagttgca 2100 actgagattc cttgtgtctg ggagtttgga cagcttcaga tgtacagttt cactagccac 2160 aaagcacagg tacaaactgg gtcatcgcct gttcacaaaa tgctctcttg atcttatttg 2220 cctcatcttc ctcatggttg tacagaggat agcaccccac catgccagcc tgacttggag 2280 atatctcctg ctgcctgcct gcagggagtt accccagttt ccaaaaacag tcgcccagat 2340 aaaggaggaa aagggaaagg cagacgaatg gcatggcttt tactaaagaa aagatgttgg 2400 cctcatactc tatactcagg gcttaatgaa ctggaatctg cataactcag cagtcaaccc 2460 agaagggaaa tggttaaact gagcttgtta ttgcctcgga gagcctaaga gcacccgcac 2520 acttaattct actccctgtc tagaaaagct gtcagggagt cgtttggaat tgcaatgtag 2580 ttattaaggg ctgttaacca gcctgcatta catctggaag tcaggacttg ggtgctgact 2640 atgaagggcc ctgttttcaa aatctaacat tgcaagtgta aatgggcaag aagcctccgt 2700 tgtgcttttt tttcctcttc agtaactttt gcaacattat tgcatagaag atccctgacc 2760 atttactagg aacctggtta agcaagcact aatctctttt cctggagatc aaggatgcaa 2820 cctcaggttg agaaagaaac agggttccct gggcccatta gactgtttgc agggcatcac 2880 tgcttccccc tgacacctca caactagcaa aaattgtctt tgtctttgga aattatagag 2940 ggatttgggt atccagattg tgcagatgca aacttaggct gtcttgatgc aaacttagaa 3000 ccacagaaat gcttttaaaa tgcctgtttt aagatggaat tgttgttttt ataatttgat 3060 tttagtgcta aataaatgat tggctttgta catgaatatg ttctgtacaa gtgctctttc 3120 actagtacta cagataatca aagctatcag aattgtgtct ttgatcatat ttgacggtaa 3180 tacacaaata aatccatgtt ttagc 3205 <210> 114 <211> 1837 <212> DNA <213> Homo sapiens <400> 114 ttttcctgac cccaaccatc ctgcccagtc tccgcttccc cgtcttgtac acccctaact 60 cctgaggctc ctccgaatca cgcgagtgga agcggagaag ctcaagtggc cgccatgtca 120 gaggcttatt tccgagtgga gtcgggtgcg ctggggcctg aggagaactt tctttctttg 180 gacgacatcc tgatgtccca cgagaagctg ccggtgcgca cggagaccgc catgcctcgc 240 cttggcgctt tcttcctgga gcggagcgca ggcgccgaga ctgacaacgc ggtcccacag 300 acttttatcg gacgttttcg ccgcatcatg gactcctcac agaatgctta caacgaagac 360 acttcagccc tggtagccag gctagacgag atggagaggg gcttatttca aacagggcag 420 aaaggactga atgactttca gtgttgggag aaggggcagg cttctcagat cacagcttcc 480 aacctcgttc agaattacaa gaagagaaaa ttcactgata tggaagactg aaagccggaa 540 gaacacagaa tggctcctca cagacgtatc cctccgtgtg tccttgatag gagctggttg 600 accttgtaca gaaccagaat cctgtcccat ttcatggctt atttcctgtg gccatagaga 660 attataggga actggacatg ctggaggatg tgggtgtccc tggctctgtg agtcttccag 720 gaccgtccca ccctgctgac ccacagccca ggccctttaa cccaagaacc catggccaag 780 gagaaatcaa agtccttcct aaataagaat cactgccata taatatatca cagtagagtt 840 gcaactgaga ttccttgtgt ctgggagttt ggacagcttc agatgtacag tttcactagc 900 cacaaagcac aggtacaaac tgggtcatcg cctgttcaca aaatgctctc ttgatcttat 960 ttgcctcatc ttcctcatgg ttgtacagag gatagcaccc caccatgcca gcctgacttg 1020 gagatatctc ctgctgcctg cctgcaggga gttaccccag tttccaaaaa cagtcgccca 1080 gataaaggag gaaaagggaa aggcagacga atggcatggc ttttactaaa gaaaagatgt 1140 tggcctcata ctctatactc agggcttaat gaactggaat ctgcataact cagcagtcaa 1200 cccagaaggg aaatggttaa actgagcttg ttattgcctc ggagagccta agagcacccg 1260 cacacttaat tctactccct gtctagaaaa gctgtcaggg agtcgtttgg aattgcaatg 1320 tagttattaa gggctgttaa ccagcctgca ttacatctgg aagtcaggac ttgggtgctg 1380 actatgaagg gccctgtttt caaaatctaa cattgcaagt gtaaatgggc aagaagcctc 1440 cgttgtgctt ttttttcctc ttcagtaact tttgcaacat tattgcatag aagatccctg 1500 accatttact aggaacctgg ttaagcaagc actaatctct tttcctggag atcaaggatg 1560 caacctcagg ttgagaaaga aacagggttc cctgggccca ttagactgtt tgcagggcat 1620 cactgcttcc ccctgacacc tcacaactag caaaaattgt ctttgtcttt ggaaattata 1680 gagggatttg ggtatccaga ttgtgcagat gcaaacttag gctgtcttga tgcaaactta 1740 gaaccacaga aatgctttta aaatgcctgt tttaagatgg aattgttgtt tttataattt 1800 gattttagtg ctaaataaat gattggcttt gtacatg 1837 <210> 115 <211> 1513 <212> DNA <213> Homo sapiens <400> 115 gatctcacag atgctacacg agacacttca gccctggtag ccaggctaga cgagatggag 60 aggggcttat ttcaaacagg gcagaaagga ctgaatgact ttcagtgttg ggagaagggg 120 caggcttctc agatcacagc ttccaacctc gttcagaatt acaagaagag aaaattcact 180 gatatggaag actgaaagcc ggaagaacac agaatggctc ctcacagacg tatccctccg 240 tgtgtccttg ataggagctg gttgaccttg tacagaacca gaatcctgtc ccatttcatg 300 gcttatttcc tgtggccata gagaattata gggaactgga catgctggag gatgtgggtg 360 tccctggctc tgtgagtctt ccaggaccgt cccaccctgc tgacccacag cccaggccct 420 ttaacccaag aacccatggc caaggagaaa tcaaagtcct tcctaaataa gaatcactgc 480 catataatat atcacagtag agttgcaact gagattcctt gtgtctggga gtttggacag 540 cttcagatgt acagtttcac tagccacaaa gcacaggtac aaactgggtc atcgcctgtt 600 cacaaaatgc tctcttgatc ttatttgcct catcttcctc atggttgtac agaggatagc 660 accccaccat gccagcctga cttggagata tctcctgctg cctgcctgca gggagttacc 720 ccagtttcca aaaacagtcg cccagataaa ggaggaaaag ggaaaggcag acgaatggca 780 tggcttttac taaagaaaag atgttggcct catactctat actcagggct taatgaactg 840 gaatctgcat aactcagcag tcaacccaga agggaaatgg ttaaactgag cttgttattg 900 cctcggagag cctaagagca cccgcacact taattctact ccctgtctag aaaagctgtc 960 agggagtcgt ttggaattgc aatgtagtta ttaagggctg ttaaccagcc tgcattacat 1020 ctggaagtca ggacttgggt gctgactatg aagggccctg ttttcaaaat ctaacattgc 1080 aagtgtaaat gggcaagaag cctccgttgt gctttttttt tcctcttcag taacttttgc 1140 aacattattg catagaagat ccctgaccat ttactaggaa cctggttaag caagcactaa 1200 tctcttttcc tggagatcaa ggatgcaacc tcaggttgag aaagaaacag ggttccctgg 1260 gcccattaga ctgtttgcag ggcatcactg cttccccctg acacctcaca actagcaaaa 1320 attgtctttg tctttggaaa ttatagaggg atttgggtat ccagattgtg cagatgcaaa 1380 cttaggctgt cttgatgcaa acttagaacc acagaaatgc ttttaaaatg cctgttttaa 1440 gatggaattg ttgtttttat aatttgattt tagtgctaaa taaatgattg gctttgtaca 1500 tgaaaaaaaa aaa 1513 <210> 116 <211> 1938 <212> DNA <213> Homo sapiens <400> 116 gatttggcgg gagtcttgac cgccgccggg ctcttggtac ctcagcgcga gcgccaggcg 60 tccggccgcc gtggctatgt tcgtgtccga tttccgcaaa gagttctacg aggtggtcca 120 gagccagagg gtccttctct tcgtggcctc ggacgtggat gctctgtgtg cgtgcaagat 180 ccttcaggcc ttgttccagt gtgaccacgt gcaatatacg ctggttccag tttctgggtg 240 gcaagaactt gaaactgcat ttcttgagca taaagaacag tttcattatt ttattctcat 300 aaactgtgga gctaatgtag acctattgga tattcttcaa cctgatgaag acactatatt 360 ctttgtgtgt gacacccata ggccagtcaa tgtcgtcaat gtatacaacg atacccagat 420 caaattactc attaaacaag atgatgacct tgaagttccc gcctatgaag acatcttcag 480 ggatgaagag gaggatgaag agcattcagg aaatgacagt gatgggtcag agccttctga 540 gaagcgcaca cggttagaag aggagatagt ggagcaaacc atgcggagga ggcagcggcg 600 agagtgggag gcccggagaa gagacatcct ctttgactac gagcagtatg aatatcatgg 660 gacatcgtca gccatggtga tgtttgagct ggcttggatg ctgtccaagg acctgaatga 720 catgctgtgg tgggccatcg ttggactaac agaccagtgg gtgcaagaca agatcactca 780 aatgaaatac gtgactgatg ttggtgtcct gcagcgccac gtttcccgcc acaaccaccg 840 gaacgaggat gaggagaaca cactctccgt ggactgcaca cggatctcct ttgagtatga 900 cctccgcctg gtgctctacc agcactggtc cctccatgac agcctgtgca acaccagcta 960 taccgcagcc aggttcaagc tgtggtctgt gcatggacag aagcggctcc aggagttcct 1020 tgcagacatg ggtcttcccc tgaagcaggt gaagcagaag ttccaggcca tggacatctc 1080 cttgaaggag aatttgcggg aaatgattga agagtctgca aataaatttg ggatgaagga 1140 catgcgcgtg cagactttca gcattcattt tgggttcaag cacaagtttc tggccagcga 1200 cgtggtcttt gccaccatgt ctttgatgga gagccccgag aaggatggct cagggacaga 1260 tcacttcatc caggctctgg acagcctctc caggagtaac ctggacaagc tgtaccatgg 1320 cctggaactc gccaagaagc agctgcgagc cacccagcag accattgcca gctgcctttg 1380 caccaacctc gtcatctccc aggggccttt cctgtactgc tctctcatgg agggcactcc 1440 agatgtcatg ctgttctcta ggccggcatc cctaagcctg ctcagcaaac acctgctcaa 1500 gtcctttgtg tgttcgacaa agaaccggcg ctgcaaactg ctgcccctgg tgatggctgc 1560 ccccctgagc atggagcatg gcacagtgac cgtggtgggc atccccccag agaccgacag 1620 ctcggacagg aagaactttt ttgggagggc gtttgagaag gcagcggaaa gcaccagctc 1680 ccggatgctg cacaaccatt ttgacctctc agtaattgag ctgaaagctg aggatcggag 1740 caagtttctg gacgcactta tttccctcct gtcctaggaa tttgattctt ccagaatgac 1800 cttcttattt atgtaactgg ctttcattta gattgtaagt tatggacatg atttgagatg 1860 tagaagccat tttttattaa ataaaatgct tattttaggc tccgtcccca aaaaaaaaaa 1920 aaaaaaaaaa aaaaaaaa 1938 <210> 117 <211> 1860 <212> DNA <213> Homo sapiens <400> 117 cctcgtgccg ccgggctctt ggtacctcag cgcgagcgcc aggcgtccgg ccgccgtggc 60 tatgttcgtg tccgatttcc gcaaagagtt ctacgaggtg gtccagagcc agagggtcct 120 tctcttcgtg gcctcggacg tggatgctct gtgtgcgtgc aagatccttc aggccttgtt 180 ccagtgtgac cacgtgcaat atacgctggt tccagtttct gggtggcaag aacttgaaac 240 tgcatttctt gagcataaag aacagtttca ttattttatt ctcataaact gtggagctaa 300 tgtagaccta ttggatattc ttcaacctga tgaagacact atattctttg tgtgtgacac 360 ccataggcca gtcaatgtcg tcaatgtata caacgatacc cagatcaaat tactcattaa 420 acaagatgat gaccttgaag ttcccgccta tgaagacatc ttcagggatg aagaggagga 480 tgaagagcat tcaggaaatg acagtgatgg gtcagagcct tctgagaagc gcacacggtt 540 agaagaggag atagtggagc aaaccatgcg gaggaggcag cggcgagagt gggaggcccg 600 gagaagagac atcctctttg actacgagca gtatgaatat catgggacat cgtcagccat 660 ggtgatgttt gagctggctt ggatgctgtc caaggacctg aatgacatgc tgtggtgggc 720 catcgttgga ctaacagacc agtgggtgca agacaagatc actcaaatga aatacgtgac 780 tgatgttggt gtcctgcagc gccacgtttc ccgccacaac caccggaacg aggatgagga 840 gaacacactc tccgtggact gcacacggat ctcctttgag tatgacctcc gcctggtgct 900 ctaccagcac tggtccctcc atgacagcct gtgcaacacc agctataccg cagccaggtt 960 caagctgtgg tctgtgcatg gacagaagcg gctccaggag ttccttgcag acatgggtct 1020 tcccctgaag caggtgaagc agaagttcca ggccatggac atctccttga aggagaattt 1080 gcgggaaatg attgaagagt ctgcaaataa atttgggatg aaggacatgc gcgtgcagac 1140 tttcagcatt cattttgggt tcaagcacaa gtttctggcc agcgacgtgg tctttgccac 1200 catgtctttg atggagagcc ccgagaagga tggctcaggg acagatcact tcatccaggc 1260 tctggacagc ctctccagga gtaacctgga caagctgtac catggcctgg aactcgccaa 1320 gaagcagctg cgagccaccc agcagaccat tgccagctgc ctttgcacca acctcgtcat 1380 ctcccagggg cctttcctgt actgctctct catggagggc actccagatg tcatgctgtt 1440 ctctaggccg gcatccctaa gcctgctcag caaacacctg ctcaagtcct ttgtgtgttc 1500 gacaaagaac cggcgctgca aactgctgcc cctggtgatg gctgcccccc tgagcatgga 1560 gcatggcaca gtgaccgtgg tgggcatccc cccagagacc gacagctcgg acaggaagaa 1620 cttttttggg agggcgtttg agaaggcagc ggaaagcacc agctcccgga tgctgcacaa 1680 ccattttgac ctctcagtaa ttgagctgaa agctgaggat cggagcaagt ttctggacgc 1740 acttatttcc ctcctgtcct aggaatttga ttcttccaga atgaccttct tatttatgta 1800 actggctttc atttagattg taagttatgg acatgatttg agatgtagaa gccatttttt 1860 <210> 118 <211> 1701 <212> DNA <213> Homo sapiens <400> 118 atgttcgtgt ccgatttccg caaagagttc tacgaggtgg tccagagcca gagggtcctt 60 ctcttcgtgg cctcggacgt ggatgctctg tgtgcgtgca agatccttca ggccttgttc 120 cagtgtgacc acgtgcaata tacgctggtt ccagtttctg ggtggcaaga acttgaaact 180 gcatttcttg agcataaaga acagtttcat tattttattc tcataaactg tggagctaat 240 gtagacctat tggatattct tcaacctgat gaagacacta tattctttgt gtgtgacacc 300 cataggccag tcaatgtcgt caatgtatac aacgataccc agatcaaatt actcattaaa 360 caagatgatg accttgaagt tcccgcctat gaagacatct tcagggatga agaggaggat 420 gaagagcatt caggaaatga cagtgatggg tcagagcctt ctgagaagcg cacacggtta 480 gaagaggaga tagtggagca aaccatgcgg aggaggcagc ggcgagagtg ggaggcccgg 540 agaagagaca tcctctttga ctacgagcag tatgaatatc atgggacatc gtcagccatg 600 gtgatgtttg agctggcttg gatgctgtcc aaggacctga atgacatgct gtggtgggcc 660 atcgttggac taacagacca gtgggtgcaa gacaagatca ctcaaatgaa atacgtgact 720 gatgttggtg tcctgcagcg ccacgtttcc cgccacaacc accggaacga ggatgaggag 780 aacacactct ccgtggactg cacacggatc tcctttgagt atgacctccg cctggtgctc 840 taccagcact ggtccctcca tgacagcctg tgcaacacca gctataccgc agccaggttc 900 aagctgtggt ctgtgcatgg acagaagcgg ctccaggagt tccttgcaga catgggtctt 960 cccctgaagc aggtgaagca gaagttccag gccatggaca tctccttgaa ggagaatttg 1020 cgggaaatga ttgaagagtc tgcaaataaa tttgggatga aggacatgcg cgtgcagact 1080 ttcagcattc attttgggtt caagcacaag tttctggcca gcgacgtggt ctttgccacc 1140 atgtctttga tggagagccc cgagaaggat ggctcaggga cagatcactt catccaggct 1200 ctggacagcc tctccaggag taacctggac aagctgtacc atggcctgga actcgccaag 1260 aagcagctgc gagccaccca gcagaccatt gccagctgcc tttgcaccaa cctcgtcatc 1320 tcccaggggc ctttcctgta ctgctctctc atggagggca ctccagatgt catgctgttc 1380 tctaggccgg catccctaag cctgctcagc aaacacctgc tcaagtcctt tgtgtgttcg 1440 acaaagaacc ggcgctgcaa actgctgccc ctggtgatgg ctgcccccct gagcatggag 1500 catggcacag tgaccgtggt gggcatcccc ccagagaccg acagctcgga caggaagaac 1560 ttttttggga gggcgtttga gaaggcagcg gaaagcacca gctcccggat gctgcacaac 1620 cattttgacc tctcagtaat tgagctgaaa gctgaggatc ggagcaagtt tctggacgca 1680 cttatttccc tcctgtccta g 1701 <210> 119 <211> 1899 <212> DNA <213> Homo sapiens <400> 119 ggcacgaggc tcttggtacc tcagcgcgag cgccaggcgt ccggccgccg tggctatgtt 60 cgtgtccgat ttccgcaaag agttctacga ggtggtccag agccagaggg tccttctctt 120 cgtggcctcg gacgtggatg ctctgtgtgc gtgcaagatc cttcaggcct tgttccagtg 180 tgaccacgtg caatatacgc tggttccagt ttctgggtgg caagaacttg aaactgcatt 240 tcttgagcat aaagaacagt ttcattattt tattctcata aactgtggag ctaatgtaga 300 cctattggat attcttcaac ctgatgaaga cactatattc tttgtgtgtg acacccatag 360 gccagtcaat gtcgtcaatg tatacaacga tacccagatc aaattactca ttaaacaaga 420 tgatgacctt gaagttcccg cctatgaaga catcttcagg gatgaagagg aggatgaaga 480 gcattcagga aatgacagtg atgggtcaga gccttctgag aagcgcacac ggttagaaga 540 ggagatagtg gagcaaacca tgcggaggag gcagcggcga gagtgggagg cccggagaag 600 agacatcctc tttgactacg agcagtatga atatcatggg acatcgtcag ccatggtgat 660 gtttgagctg gcttggatgc tgtccaagga cctgaatgac atgctgtggt gggccatcgt 720 tggactaaca gaccagtggg tgcaagacaa gatcactcaa atgaaatacg tgactgatgt 780 tggtgtcctg cagcgccacg tttcccgcca caaccaccgg aacgaggatg aggagaacac 840 actctccgtg gactgcacac ggatctcctt tgagtatgac ctccgcctgg tgctctacca 900 gcactggtcc ctccatgaca gcctgtgcaa caccagctat accgcagcca ggttcaagct 960 gtggtctgtg catggacaga agcggctcca ggagttcctt gcagacatgg gtcttcccct 1020 gaagcaggtg aagcagaagt tccaggccat ggacatctcc ttgaaggaga atttgcggga 1080 aatgattgaa gagtctgcaa ataaatttgg gatgaaggac atgcgcgtgc agactttcag 1140 cattcatttt gggttcaagc acaagtttct ggccagcgac gtggtctttg ccaccatgtc 1200 tttgatggag agccccgaga aggatggctc agggacagat cacttcatcc aggctctgga 1260 cagcctctcc aggagtaacc tggacaagct gtaccatggc ctggaactcg ccaagaagca 1320 gctgcgagcc acccagcaga ccattgccag ctgcctttgc accaacctcg tcatctccca 1380 ggggcctttc ctgtactgct ctctcatgga gggcactcca gatgtcatgc tgttctctag 1440 gccggcatcc ctaagcctgc tcagcaaaca cctgctcaag tcctttgtgt gttcgacaaa 1500 gaaccggcgc tgcaaactgc tgcccctggt gatggctgcc cccctgagca tggagcatgg 1560 cacagtgacc gtggtgggca tccccccaga gaccgacagc tcggacagga agaacttttt 1620 tgggagggcg tttgagaagg cagcggaaag caccagctcc cggatgctgc acaaccattt 1680 tgacctctca gtaattgagc tgaaagctga ggatcggagc aagtttctgg acgcacttat 1740 ttccctcctg tcctaggaat ttgattcttc cagaatgacc ttcttattta tgtaactggc 1800 tttcatttag attgtaagtt atggacatga tttgagatgt agaagccatt ttttattaaa 1860 taaaatgctt attttaaaaa aaaaaaaaaa aaaaaaaaa 1899 <210> 120 <211> 1893 <212> DNA <213> Homo sapiens <400> 120 cgcgagcgcc aggcgtccgg ccgccgtggc tatgttcgtg tccgatttcc gcaaagagtt 60 ctacgaggtg gtccagagcc agagggtcct tctcttcgtg gcctcggacg tggatgctct 120 gtgtgcgtgc aagatccttc aggccttgtt ccagtgtgac cacgtgcaat atacgctggt 180 tccagtttct gggtggcaag aacttgaaac tgcatttctt gagcataaag aacagtttca 240 ttattttatt ctcataaact gtggagctaa tgtagaccta ttggatattc ttcaacctga 300 tgaagacact atattctttg tgtgtgacac ccataggcca gtcaatgtcg tcaatgtata 360 caacgatacc cagatcaaat tactcattaa acaagatgat gaccttgaag ttcccgccta 420 tgaagacatc ttcagggatg aagaggagga tgaagagcat tcaggaaatg acagtgatgg 480 gtcagagcct tctgagaagc gcacacggtt agaagaggag atagtggagc aaaccatgcg 540 gaggaggcag cggcgagagt gggaggcccg gagaagagac atcctctttg actacgagca 600 gtatgaatat catgggacat cgtcagccat ggtgatgttt gagctggctt ggatgctgtc 660 caaggacctg aatgacatgc tgtggtgggc catcgttgga ctaacagacc agtgggtgca 720 agacaagatc actcaaatga aatacgtgac tgatgttggt gtcctgcagc gccacgtttc 780 ccgccacaac caccggaacg aggatgagga gaacacactc tccgtggact gcacacggat 840 ctcctttgag tatgacctcc gcctggtgct ctaccagcac tggtccctcc atgacagcct 900 gtgcaacacc agctataccg cagccaggtt caagctgtgg tctgtgcatg gacagaagcg 960 gctccaggag ttccttgcag acatgggtct tcccctgaag caggtgaagc agaagttcca 1020 ggccatggac atctccttga aggagaattt gcgggaaatg attgaagagt ctgcaaataa 1080 atttgggatg aaggacatgc gcgtgcagac tttcagcatt cattttgggt tcaagcacaa 1140 gtttctggcc agcgacgtgg tctttgccac catgtctttg atggagagcc ccgagaagga 1200 tggctcaggg acagatcact tcatccaggc tctggacagc ctctccagga gtaacctgga 1260 caagctgtac catggcctgg aactcgccaa gaagcagctg cgagccaccc agcagaccat 1320 tgccagctgc ctttgcacca acctcgtcat ctcccagggg cctttcctgt actgctctct 1380 catggagggc actccagatg tcatgctgtt ctctaggccg gcatccctaa gcctgctcag 1440 caaacacctg ctcaagtcct ttgtgtgttc gacaaagaac cggcgctgca aactgctgcc 1500 cctggtgatg gctgcccccc tgagcatgga gcatggcaca gtgaccgtgg tgggcatccc 1560 cccagagacc gacagctcgg acaggaagaa cttttttggg agggcgtttg agaaggcagc 1620 ggaaagcacc agctcccgga tgctgcacaa ccattttgac ctctcagtaa ttgagctgaa 1680 agctgaggat cggagcaagt ttctggacgc acttatttcc ctcctgtcct aggaatttga 1740 ttcttccaga atgaccttct tatttatgta actggctttc atttagattg taagttatgg 1800 acatgatttg agatgtagaa gccatttttt attaaataaa atgcttattt taggctccgt 1860 ccccaaaaaa aaaaaaaaaa aaaaaaaaaa aaa 1893 <210> 121 <211> 1865 <212> DNA <213> Homo sapiens <400> 121 gccaggcgtc cggccgccgt ggctatgttc gtgtccgatt tccgcaaaga gttctacgag 60 gtggtccaga gccagagggt ccttctcttc gtggcctcgg acgtggatgc tctgtgtgcg 120 tgcaagatcc ttcaggcctt gttccagtgt gaccacgtgc aatatacgct ggttccagtt 180 tctgggtggc aagaacttga aactgcattt cttgagcata aagaacagtt tcattatttt 240 attctcataa actgtggagc taatgtagac ctattggata ttcttcaacc tgatgaagac 300 actatattct ttgtgtgtga cacccatagg ccagtcaatg tcgtcaatgt atacaacgat 360 acccagatca aattactcat taaacaagat gatgaccttg aagttcccgc ctatgaagac 420 atcttcaggg atgaagagga ggatgaagag cattcaggaa atgacagtga tgggtcagag 480 ccttctgaga agcgcacacg gttagaagag gagatagtgg agcaaaccat gcggaggagg 540 cagcggcgag agtgggaggc ccggagaaga gacatcctct ttgactacga gcagtatgaa 600 tatcatggga catcgtcagc catggtgatg tttgagctgg cttggatgct gtccaaggac 660 ctgaatgaca tgctgtggtg ggccatcgtt ggactaacag accagtgggt gcaagacaag 720 atcactcaaa tgaaatacgt gactgatgtt ggtgtcctgc agcgccacgt ttcccgccac 780 aaccaccgga acgaggatga ggagaacaca ctctccgtgg actgcacacg gatctccttt 840 gagtatgacc tccgcctggt gctctaccag cactggtccc tccatgacag cctgtgcaac 900 accagctata ccgcagccag gttcaagctg tggtctgtgc atggacagaa gcggctccag 960 gagttccttg cagacatggg tcttcccctg aagcaggtga agcagaagtt ccaggccatg 1020 gacatctcct tgaaggagaa tttgcgggaa atgattgaag agtctgcaaa taaatttggg 1080 atgaaggaca tgcgcgtgca gactttcagc attcattttg ggttcaagca caagtttctg 1140 gccagcgacg tggtctttgc caccatgtct ttgatggaga gccccgagaa ggatggctca 1200 gggacagatc acttcatcca ggctctggac agcctctcca ggagtaacct ggacaagctg 1260 taccatggcc tggaactcgc caagaagcag ctgcgagcca cccagcagac cattgccagc 1320 tgcctttgca ccaacctcgt catctcccag gggcctttcc tgtactgctc tctcatggag 1380 ggcactccag atgtcatgct gttctctagg ccggcatccc taagcctgct cagcaaacac 1440 ctgctcaagt cctttgtgtg ttcgacaaag aaccggcgct gcaaactgct gcccctggtg 1500 atggctgccc ccctgagcat ggagcatggc acagtgaccg tggtgggcat ccccccagag 1560 accgacagct cggacaggaa gaactttttt gggagggcgt ttgagaaggc agcggaaagc 1620 accagctccc ggatgctgca caaccatttt gacctctcag taattgagct gaaagctgag 1680 gatcggagca agtttctgga cgcacttatt tccctcctgt cctaggaatt tgattcttcc 1740 agaatgacct tcttatttat gtaactggct ttcatttaga ttgtaagtta tggacatgat 1800 ttgagatgta gaagccattt tttattaaat aaaatgctta ttttagaaaa aaaaaaaaaa 1860 aaaaa 1865 <210> 122 <211> 1892 <212> DNA <213> Homo sapiens <400> 122 gagtcttgac cgccgccggg ctcttggtac ctcagcgcga gcgccaggcg tccggccgcc 60 gtggctatgt tcgtgtccga tttccgcaaa gagttctacg aggtggtcca gagccagagg 120 gtccttctct tcgtggcctc ggacgtggat gctctgtgtg cgtgcaagat ccttcaggcc 180 ttgttccagt gtgaccacgt gcaatatacg ctggttccag tttctgggtg gcaagaactt 240 gaaactgcat ttcttgagca taaagaacag tttcattatt ttattctcat aaactgtgga 300 gctaatgtag acctattgga tattcttcaa cctgatgaag acactatatt ctttgtgtgt 360 gactcccata ggccagtcaa tgtcgtcaat gtatacaacg atacccagat caaattactc 420 attaaacaag atgatgacct tgaagttccc gcctatgaag acatcttcag ggatgaagag 480 gaggatgaag agcattcagg aaatgacagt gatgggtcag agccttctga gaagcgcaca 540 cggttagaag aggagatagt ggagcaaacc atgcggagga ggcagcggcg agagtgggag 600 gcccggagaa gagacatcct ctttgactac gagcagtatg aatatcatgg gacatcgtca 660 gccatggtga tgtttgagct ggcttggatg ctgtccaagg acctgaatga catgctgtgg 720 tgggccatcg ttggactaac agaccagtgg gtgcaagaca agatcactca aatgaaatac 780 gtgactgatg ttggtgtcct gcagcgccac gtttcccgcc acaaccaccg gaacgaggat 840 gaggagaaca cactctccgt ggactgcaca cggatctcct ttgagtatga cctccgcctg 900 gtgctctacc agcactggtc cctccatgac agcctgtgca acaccagcta taccgcagcc 960 aggttcaagc tgtggtctgt gcatggacag aagcggctcc aggagttcct tgcagacatg 1020 ggtcttcccc tgaagcaggt gaagcagaag ttccaggcca tggacatctc cttgaaggag 1080 aatttgcggg aaatgattga agagtctgca aataaatttg ggatgaagga catgcgcgtg 1140 cagactttca gcattcattt tgggttcaag cacaagtttc tggccagcga cgtggtcttt 1200 gccaccatgt ctttgatgga gagccccgag aaggatggct cagggacaga tcacttcatc 1260 caggctctgg acagcctctc caggagtaac ctggacaagc tgtaccatgg cctggaactc 1320 gccaagaagc agctgcgagc cacccagcag accattgcca gctgcctttg caccaacctc 1380 gtcatctccc aggggccttt cctgtactgc tctctcatgg agggcactcc agatgtcatg 1440 ctgttctcta ggccggcatc cctaagcctg ctcagcaaac acctgctcaa gtcctttgtg 1500 tgttcgacaa agaaccggcg ctgcaaactg ctgcccctgg tgatggctgc ccccctgagc 1560 atggagcatg gcacagtgac cgtggtgggc atccccccag agaccgacag ctcggacagg 1620 aagaactttt ttgggagggc gtttgagaag gcagcggaaa gcaccagctc ccggatgctg 1680 cacaaccatt ttgacctctc agtaattgag ctgaaagctg aggatcggag caagtttctg 1740 gacgcactta tttccctcct gtcctaggaa tttgattctt ccagaatgac cttcttattt 1800 atgtaactgg ctttcattta gattgtaagt tatggacatg atttgagatg tagaagccat 1860 tttttattaa ataaaatgct tattttagga aa 1892 <210> 123 <211> 1856 <212> DNA <213> Homo sapiens <400> 123 cccggccgcc gtggctatgt tcgtgtccga tttccgcaaa gagttctacg aggtggtcca 60 gagccagagg gtccttctct tcgtggcctc ggacgtggat gctctgtgtg cgtgcaagat 120 ccttcaggcc ttgttccagt gtgaccacgt gcaatatacg ctggttccag tttctgggtg 180 gcaagaactt gaaactgcat ttcttgagca taaagaacag tttcattatt ttattctcat 240 aaactgtgga gctaatgtag acctattgga tattcttcaa cctgatgaag acactatatt 300 ctttgtgtgt gacacccata ggccagtcaa tgtcgtcaat gtatacaacg atacccagat 360 caaattactc attaaacaag atgatgacct tgaagttccc gcctatgaag acatcttcag 420 ggatgaagag gaggatgaag agcattcagg aaatgacagt gatgggtcag agccttctga 480 gaagcgcaca cggttagaag aggagatagt ggagcaaacc atgcggagga ggcagcggcg 540 agagtgggag gcccggagaa gagacatcct ctttgactac gagcagtatg aatatcatgg 600 gacatcgtca gccatggtga tgtttgagct ggcttggatg ctgtccaagg acttgaatga 660 catgctgtgg tgggccatcg ttggactaac agaccagtgg gtgcaagaca agatcactca 720 aatgaaatac gtgactgatg ttggtgtcct gcagcgccac gtttcccgcc acaaccaccg 780 gaacgaggat gaggagaaca cactctccgt ggactgcaca cggatctcct ttgagtatga 840 cctccgcctg gtgctctacc agcactggtc cctccatgac agcctgtgca acaccagcta 900 taccgcagcc aggttcaagc tgtggtctgt gcatggacag aagcggctcc aggagttcct 960 tgcagacatg ggtcttcccc tgaagcaggt gaagcagaag ttccaggcca tggacatctc 1020 cttgaaggag aatttgcggg aaatgattga acagtctgca aataaatttg ggatgaagga 1080 catgcgcgtg cagactttca gcattcattt tgggttcaag cacaagtttc tggccagcga 1140 cgtggtcttt gccaccatgt ctttgatgga gagccccgag aaggatggct cagggacaga 1200 tcacttcatc caggctctgg acagcctctc caggagtaac ctggacaagc tgtaccatgg 1260 cctggaactc gccaagaagc agctgcgagc cacccagcag accattgcca gctgcctttg 1320 caccaacctc gtcatctccc aggggccttt cctgtactgc tctctcatgg agggcactcc 1380 agatgtcatg ctgttctcta ggccggcatc cctaagcctg ctcagcaaac acctgctcaa 1440 gtcctttgtg tgttcgacaa agaaccggcg ctgcaaactg ctgcccctgg tgatggctgc 1500 ccccctgagc atggagcatg gcacagtgac cgtggtgggc atccccccag agaccgacag 1560 ctcggacagg aagaactttt ttgggagggc gtttgagaag gcagcggaaa gcaccagctc 1620 ccggatgctg cacaaccatt ttgacctctc agtaattgag ctgaaagctg aggatcggag 1680 caagtttctg gacgcactta tttccctcct gtcctaggaa tttgattctt ccagaatgac 1740 cttcttattt atgtaactgg ctttcattta gattgtaagt tatggacatg atttgagatg 1800 tagaagccat tttttattaa ataaaatgct tattttaggc tccgtcaaaa aaaaaa 1856 <210> 124 <211> 1871 <212> DNA <213> Homo sapiens <400> 124 gcgagcgcca ggcgtccggc cgccgtggct atgttcgtgt ccgatttccg caaagagttc 60 tacgaggtgg tccagagcca gagggtcctt ctcttcgtgg cctcggacgt ggatgctctg 120 tgtgcgtgca agatccttca ggccttgttc cagtgtgacc acgtgcaata tacgctggtt 180 ccagtttctg ggtggcaaga acttgaaact gcatttcttg agcataaaga acagtttcat 240 tattttattc tcataaactg tggagctaat gtagacctat tggatattct tcaacctgat 300 gaagacacta tattctttgt gtgtgacacc cataggccag tcaatgtcgt caatgtatac 360 aacgataccc aggtcaaatt actcattaaa caagatgatg accttgaagt tcccgcctat 420 gaagacatct tcagggatga agaggaggat gaagagcatt caggaaatga cagtgatggg 480 tcagagcctt ctgagaagcg cacacggtta gaagaggaga tagtggagca aaccatgcgg 540 aggaggcagc ggcgagagtg ggaggcccgg agaagagaca tcctctttga ctacgagcag 600 tatgaatatc atgggacatc gtcagccatg gtgatgtttg agctggcttg gatgctgtcc 660 aaggacctga atgacatgct gtggtgggcc atcgttggac taacagacca gtgggtgcaa 720 gacaagatca ctcaaatgaa atacgtgact gatgttggtg tcctgcagcg ccacgtttcc 780 cgccacaacc accggaacga ggatgaggag aacacactct ccgtggactg cacacggatc 840 tcctttgagt atgacctccg cctggtgctc taccagcact ggtccctcca tgacagcctg 900 tgcaacacca gctataccgc agccaggttc aagctgtggt ctgtgcatgg acagaagcgg 960 ctccaggagt tccttgcaga catgggtctt cccctgaagc aggtgaagca gaagttccag 1020 gccatggaca tctccttgaa ggagaatttg cgggaaatga ttgaagaatc tgcaaataaa 1080 tttgggatga aggacatgcg cgtgcagact ttcagcattc attttgggtt caagcacaag 1140 tttctggcca gcgacgtggt ctttgccacc atgtctttga tggagagccc cgagaaggat 1200 ggctcaggga cagatcactt catccaggct ctggacagcc tctccaggag taacctggac 1260 aagctgtacc atggcctgga actcgccaag aagcagctgc gagccaccca gcagaccatt 1320 gccagctgcc tttgcaccaa cctcgtcatc tcccaggggc ctttcctgta ctgctctctc 1380 atggagggca ctccagatgt catgctgttc tctaggccgg catccctaag cctgctcagc 1440 aaacacctgc tcaagtcctt tgtgtgttcg acaaagaacc ggcgctgcaa actgctgccc 1500 ctggtgatgg ctgcccccct gagcatggag catggcacag tgaccgtggt gggcatcccc 1560 ccagagaccg acagctcgga caggaagaac ttttttggga gggcgtttga gaaggcagcg 1620 gaaagcacca gctcccggat gctgcacaac cattttgacc tctcagtaat tgagctgaaa 1680 gctgaggatc ggagcaagtt tctggacgca cttatttccc tcctgtccta ggaatttgat 1740 tcttccagaa tgaccttctt atttatgtaa ctggctttca tttagattgt aagttatgga 1800 catgatttga gatgtagaag ccatttttta ttaaataaaa tgcttatttt agaaaaaaaa 1860 aaaaaaaaaa a 1871 <210> 125 <211> 5433 <212> DNA <213> Homo sapiens <400> 125 ggggagattc gggaccatgg cacctgtgca cggcgacgac tctctgtcag attcagggag 60 ttttgtatct tctcgagccc ggcgagaaaa aaaatcaaag aaggggcgcc aagaagccct 120 agaaagactg aaaaaggcta aagctggtga gaagtataaa tatgaagtcg aggacttcac 180 aggtgtttat gaagaagttg atgaagaaca gtattcgaag ctggttcagg cacgccagga 240 tgatgactgg attgtggatg atgatggtat tggctatgtg gaagatggcc gagagatttt 300 tgatgatgac cttgaagatg atgcccttga tgctgatgag aaaggaaaag atggtaaagc 360 acgcaataaa gacaagagga atgtaaagaa gctcgcagtg acaaaaccga acaacattaa 420 gtcaatgttc attgcttgtg ctggaaagaa aactgcagat aaagctgtag acttgtccaa 480 ggatggtctg ctaggtgaca ttctacagga tcttaacact gagacacctc aaataactcc 540 accacctgta atgatactga agaagaaaag atccattgga gcttcaccga atcctttctc 600 tgtgcacacc gccacggcag ttccttcagg aaaaattgct tcccctgtct ccagaaagga 660 gcctccatta actcctgttc ctcttaaacg tgctgaattt gctggcgatg atgtacaggt 720 cgagagtaca gaagaagagc aggagtcagg ggcaatggag tttgaagatg gtgactttga 780 tgagcccatg gaagttgaag aggtggacct ggagcctatg gctgccaagg cttgggacaa 840 agagagtgag ccagcagagg aagtgaaaca agaggcggat tctgggaaag ggaccgtgtc 900 ctacttagga agttttctcc cggatgtctc ttgttgggac attgatcaag aaggtgatag 960 cagtttctca gtgcaagaag ttcaagtgga ttccagtcac ctcccattgg taaaaggggc 1020 agatgaggaa caagtattcc acttttattg gttggatgct tatgaggatc agtacaacca 1080 accaggtgtg gtatttctgt ttgggaaagt ttggattgaa tcagccgaga cccatgtgag 1140 ctgttgtgtc atggtgaaaa atatcgagcg aacgctttac ttccttcccc gtgaaatgaa 1200 aattgatcta aatacgggga aagaaacagg aactccaatt tcaatgaagg atgtttatga 1260 ggaatttgat gagaaaatag caacaaaata taaaattatg aagttcaagt ctaagccagt 1320 ggaaaagaac tatgcttttg agatacctga tgttccagaa aaatctgagt acttggaagt 1380 taaatactcg gctgaaatgc cacagcttcc tcaagatttg aaaggagaaa ctttttctca 1440 tgtatttggg accaacacat ctagcctgga actgttcttg atgaacagaa agatcaaagg 1500 accttgttgg cttgaagtaa aaaagtccac agctcttaat cagccagtca gttggtgtaa 1560 agttgaggca atggctttga aaccagacct ggtgaatgta attaaggatg tcagtccacc 1620 accgcttgtc gtgatggctt tcagcatgaa gacaatgcag aatgcaaaga accatcaaaa 1680 tgagattatt gctatggcag ctttggtcca tcacagtttt gcattggata aagcagcccc 1740 aaagcctccc tttcagtcac acttctgtgt tgtgtctaaa ccaaaggact gtatttttcc 1800 atatgctttc aaagaagtca ttgagaaaaa gaatgtgaag gttgaggttg ctgcaacaga 1860 aagaacactg ctaggttttt tccttgcaaa agttcacaaa attgatcctg atatcattgt 1920 gggtcataat atttatgggt ttgaactgga agtactactg cagagaatta atgtgtgcaa 1980 agctcctcac tggtccaaga taggtcgact gaagcgatcc aacatgccaa agcttggggg 2040 ccggagtgga tttggtgaaa gaaatgctac ctgtggtcga atgatctgtg atgtggaaat 2100 ttcagcaaag gaattgattc gttgtaaaag ctaccatctg tctgaacttg ttcagcagat 2160 tctaaaaact gaaagggttg taatcccaat ggaaaatata caaaatatgt acagtgaatc 2220 ttctcaactg ttatacctgt tggaacacac ctggaaagat gccaagttca ttttgcagat 2280 catgtgtgag ctaaatgttc ttccattagc attgcagatc actaacatcg ctgggaacat 2340 tatgtccagg acgctgatgg gtggacgatc cgagcgtaac gagttcttgt tgcttcatgc 2400 attttacgaa aacaactata ttgtgcctga caagcagatt ttcagaaagc ctcagcaaaa 2460 actgggagat gaagatgaag aaattgatgg agataccaat aaatacaaga aaggacgtaa 2520 gaaaggagct tatgctggag gcttggtttt ggaccccaaa gttggttttt atgataagtt 2580 cattttgctt ctggacttca acagtctata tccttccatc attcaggaat ttaacatttg 2640 ttttacaaca gtacaaagag ttgcttcaga ggcacagaaa gttacagagg atggagaaca 2700 agaacagatc cctgagttgc cagatccaag cttagaaatg ggcattttgc ccagagagat 2760 ccggaaactg gtagaacgga gaaaacaagt caaacagcta atgaaacagc aagacttaaa 2820 tccagacctt attcttcagt atgacattcg acagaaggct ttgaagctca cagcgaacag 2880 tatgtatggt tgcctgggat tttcctatag cagattttac gccaaaccac tggctgcctt 2940 ggtgacatac aaaggaaggg agattttgat gcatacgaaa gagatggtac aaaagatgaa 3000 tcttgaagtt atttatggag atacagattc aattatgata aacaccaata gcaccaatct 3060 ggaagaagta tttaagttgg gaaacaaggt aaaaagtgaa gtgaataagt tgtacaaact 3120 gcttgaaata gacattgatg gggttttcaa gtctctgcta ctgctgaaaa aaaagaagta 3180 cgctgctctg gttgttgagc caacgtcgga tgggaattat gtcaccaaac aggagctcaa 3240 aggattagat atagttagaa gagattggtg tgatcttgct aaagacactg gaaactttgt 3300 gattggccag attctttctg atcaaagccg ggacactata gtggaaaaca ttcagaagag 3360 gctgatagaa attggagaaa atgtgctaaa tggcagtgtc ccagtgagcc agtttgaaat 3420 taacaaggca ttgacaaagg atccccagga ttaccctgat aaaaaaagcc tacctcatgt 3480 acatgttgcc ctctggataa attctcaagg aggcagaaag gtgaaagctg gagatactgt 3540 gtcatatgtc atctgtcagg atggatcaaa cctcactgca agtcagaggg cctatgcgcc 3600 tgagcagctg cagaaacagg ataatctaac cattgacacc cagtactacc tggcccagca 3660 gatccaccca gtcgtggctc ggatctgtga accaatagac ggaattgatg ctgtcctcat 3720 tgcaacgtgg ttgggacttg accccaccca atttagagtt catcattatc ataaagatga 3780 agagaatgat gctctacttg gtggcccagc acagctcact gatgaagaga aatacaggga 3840 ctgtgaaaga ttcaaatgtc catgccctac atgtggaact gagaatattt atgataatgt 3900 ctttgatggt tcgggaacag atatggagcc cagcttgtat cgttgcagta acatcgattg 3960 taaggcttca cctctgacct ttacagtaca actgagcaac aaattgatca tggacattag 4020 acgtttcatt aaaaagtact atgatggctg gttgatatgt gaagagccaa cctgtcgcaa 4080 tcgaactcgt caccttcccc ttcaattctc ccgaactggg cctctttgcc cagcctgcat 4140 gaaagctaca cttcaaccag agtattctga caagtccctg tacacccagc tgtgctttta 4200 ccggtacatt tttgatgcgg agtgtgcact ggagaaactt actaccgatc atgagaaaga 4260 taaattgaag aagcaatttt ttacccccaa agttctgcag gactacagaa aactcaagaa 4320 cacagcagag caattcttgt cccgaagtgg ctactccgaa gtgaatctga gcaaactctt 4380 cgctggttgt gccgtgaaat cctaagggaa tcccaggagt aaccaaggag ggggtagttg 4440 aaaaatccca gcttcctctg tgcctccact ctggccctaa atgctcctcc agcatctgtt 4500 tctcccttgg gactgtgtct catgtttgtg tgaatgtaga ccaggaaagg gggctgcaaa 4560 aatgttgagt ctaatgttcg taagcatcat agaaattcct gtcttcatat taagatgtac 4620 tgctttaaaa cacaactcca gagcccctcc ccaagctccc ctccccaagc tcctgaagac 4680 ccggtttctg agggagggaa attgctactt ggattgagag tagctggaat gtaagtgacc 4740 ccaggctttg ctcagggcct ttagcctatg tcccccccac ataaagagag cttctcagag 4800 cctgactgaa gagctgacgt tttgcttttt catatgccaa ttaaacccgg tctaaatcca 4860 aatgcttctc cagccatcca ggagtggctg tccttttcag tcttgtcttt tatataggta 4920 gctgaggggg aagatttaga agccttgcac tcactaaata gattaaacag agcaggcttg 4980 tttgttgaat tgctccaaag tccaacagac acacactgag caggtgtttt acactcacat 5040 tccctttttg ccccttaaat agaaagtgca ggtaaaggtt tatacaacaa gaaagcacat 5100 tgaaaataat ttgatactct aacaatccat taacatgtgt aggggttacg gtgaggatca 5160 tgtgttgtat tcgaaaaacg gggagaggga tgcttaattg gccctcgctt gctatttttt 5220 tctcatttct tcacaatagg accgtctttg gcagcagcaa aatgtatttc agtatggcag 5280 tctttcctct cttacattat tggtaagatt atactaacaa aatgtttccc cttgtacaat 5340 tatgctgtgt ttttaaaaaa cattgacctg tgtgttttta taaaagaaaa agtatgttgt 5400 gccttcttct taagaataaa gttttctaaa ggg 5433 <210> 126 <211> 5433 <212> DNA <213> Homo sapiens <400> 126 ggggagattc gggaccatgg cacctgtgca cggcgacgac tctctgtcag attcagggag 60 ttttgtatct tctcgagccc ggcgagaaaa aaaatcaaag aaggggcgcc aagaagccct 120 agaaagactg aaaaaggcta aagctggtga gaagtataaa tatgaagtcg aggacttcac 180 aggtgtttat gaagaagttg atgaagaaca gtattcgaag ctggttcagg cacgccagga 240 tgatgactgg attgtggatg atgatggtat tggctatgtg gaagatggcc gagagatttt 300 tgatgatgac cttgaagatg atgcccttga tgctgatgag aaaggaaaag atggtaaagc 360 acgcaataaa gacaagagga atgtaaagaa gctcgcagtg acaaaaccga acaacattaa 420 gtcaatgttc attgcttgtg ctggaaagaa aactgcagat aaagctgtag acttgtccaa 480 ggatggtctg ctaggtgaca ttctacagga tcttaacact gagacacctc aaataactcc 540 accacctgta atgatactga agaagaaaag atccattgga gcttcaccga atcctttctc 600 tgtgcacacc gccacggcag ttccttcagg aaaaattgct tcccctgtct ccagaaagga 660 gcctccatta actcctgttc ctcttaaacg tgctgaattt gctggcgatg atgtacaggt 720 cgagagtaca gaagaagagc aggagtcagg ggcaatggag tttgaagatg gtgactttga 780 tgagcccatg gaagttgaag aggtggacct ggagcctatg gctgccaagg cttgggacaa 840 agagagtgag ccagcagagg aagtgaaaca agaggcggat tctgggaaag ggaccgtgtc 900 ctacttagga agttttctcc cggatgtctc ttgttgggac attgatcaag aaggtgatag 960 cagtttctca gtgcaagaag ttcaagtgga ttccagtcac ctcccattgg taaaaggggc 1020 agatgaggaa caagtattcc acttttattg gttggatgct tatgaggatc agtacaacca 1080 accaggtgtg gtatttctgt ttgggaaagt ttggattgaa tcagccgaga cccatgtgag 1140 ctgttgtgtc atggtgaaaa atatcgagcg aacgctttac ttccttcccc gtgaaatgaa 1200 aattgatcta aatacgggga aagaaacagg aactccaatt tcaatgaagg atgtttatga 1260 ggaatttgat gagaaaatag caacaaaata taaaattatg aagttcaagt ctaagccagt 1320 ggaaaagaac tatgcttttg agatacctga tgttccagaa aaatctgagt acttggaagt 1380 taaatactcg gctgaaatgc cacagcttcc tcaagatttg aaaggagaaa ctttttctca 1440 tgtatttggg accaacacat ctagcctgga actgttcttg atgaacagaa agatcaaagg 1500 accttgttgg cttgaagtaa aaaagtccac agctcttaat cagccagtca gttggtgtaa 1560 agttgaggca atggctttga aaccagacct ggtgaatgta attaaggatg tcagtccacc 1620 accgcttgtc gtgatggctt tcagcatgaa gacaatgcag aatgcaaaga accatcaaaa 1680 tgagattatt gctatggcag ctttggtcca tcacagtttt gcattggata aagcagcccc 1740 aaagcctccc tttcagtcac acttctgtgt tgtgtctaaa ccaaaggact gtatttttcc 1800 atatgctttc aaagaagtca ttgagaaaaa gaatgtgaag gttgaggttg ctgcaacaga 1860 aagaacactg ctaggttttt tccttgcaaa agttcacaaa attgatcctg atatcattgt 1920 gggtcataat atttatgggt ttgaactgga agtactactg cagagaatta atgtgtgcaa 1980 agctcctcac tggtccaaga taggtcgact gaagcgatcc aacatgccaa agcttggggg 2040 ccggagtgga tttggtgaaa gaaatgctac ctgtggtcga atgatctgtg atgtggaaat 2100 ttcagcaaag gaattgattc gttgtaaaag ctaccatctg tctgaacttg ttcagcagat 2160 tctaaaaact gaaagggttg taatcccaat ggaaaatata caaaatatgt acagtgaatc 2220 ttctcaactg ttatacctgt tggaacacac ctggaaagat gccaagttca ttttgcagat 2280 catgtgtgag ctaaatgttc ttccattagc attgcagatc actaacatcg ctgggaacat 2340 tatgtccagg acgctgatgg gtggacgatc cgagcgtaac gagttcttgt tgcttcatgc 2400 attttacgaa aacaactata ttgtgcctga caagcagatt ttcagaaagc ctcagcaaaa 2460 actgggagat gaagatgaag aaattgatgg agataccaat aaatacaaga aaggacgtaa 2520 gaaaggagct tatgctggag gcttggtttt ggaccccaaa gttggttttt atgataagtt 2580 cattttgctt ctggacttca acagtctata tccttccatc attcaggaat ttaacatttg 2640 ttttacaaca gtacaaagag ttgcttcaga ggcacagaaa gttacagagg atggagaaca 2700 agaacagatc cctgagttgc cagatccaag cttagaaatg ggcattttgc ccagagagat 2760 ccggaaactg gtagaacgga gaaaacaagt caaacagcta atgaaacagc aagacttaaa 2820 tccagacctt attcttcagt atgacattcg acagaaggct ttgaagctca cagcgaacag 2880 tatgtatggt tgcctgggat tttcctatag cagattttac gccaaaccac tggctgcctt 2940 ggtgacatac aaaggaaggg agattttgat gcatacgaaa gagatggtac aaaagatgaa 3000 tcttgaagtt atttatggag atacagattc aattatgata aacaccaata gcaccaatct 3060 ggaagaagta tttaagttgg gaaacaaggt aaaaagtgaa gtgaataagt tgtacaaact 3120 gcttgaaata gacattgatg gggttttcaa gtctctgcta ctgctgaaaa aaaagaagta 3180 cgctgctctg gttgttgagc caacgtcgga tgggaattat gtcaccaaac aggagctcaa 3240 aggattagat atagttagaa gagattggtg tgatcttgct aaagacactg gaaactttgt 3300 gattggccag attctttctg atcaaagccg ggacactata gtggaaaaca ttcagaagag 3360 gctgatagaa attggagaaa atgtgctaaa tggcagtgtc ccagtgagcc agtttgaaat 3420 taacaaggca ttgacaaagg atccccagga ttaccctgat aaaaaaagcc tacctcatgt 3480 acatgttgcc ctctggataa attctcaagg aggcagaaag gtgaaagctg gagatactgt 3540 gtcatatgtc atctgtcagg atggatcaaa cctcactgca agtcagaggg cctatgcgcc 3600 tgagcagctg cagaaacagg ataatctaac cattgacacc cagtactacc tggcccagca 3660 gatccaccca gtcgtggctc ggatctgtga accaatagac ggaattgatg ctgtcctcat 3720 tgcaacgtgg ttgggacttg accccaccca atttagagtt catcattatc ataaagatga 3780 agagaatgat gctctacttg gtggcccagc acagctcact gatgaagaga aatacaggga 3840 ctgtgaaaga ttcaaatgtc catgccctac atgtggaact gagaatattt atgataatgt 3900 ctttgatggt tcgggaacag atatggagcc cagcttgtat cgttgcagta acatcgattg 3960 taaggcttca cctctgacct ttacagtaca actgagcaac aaattgatca tggacattag 4020 acgtttcatt aaaaagtact atgatggctg gttgatatgt gaagagccaa cctgtcgcaa 4080 tcgaactcgt caccttcccc ttcaattctc ccgaactggg cctctttgcc cagcctgcat 4140 gaaagctaca cttcaaccag agtattctga caagtccctg tacacccagc tgtgctttta 4200 ccggtacatt tttgatgcgg agtgtgcact ggagaaactt actaccgatc atgagaaaga 4260 taaattgaag aagcaatttt ttacccccaa agttctgcag gactacagaa aactcaagaa 4320 cacagcagag caattcttgt cccgaagtgg ctactccgaa gtgaatctga gcaaactctt 4380 cgctggttgt gccgtgaaat cctaagggaa tcccaggagt aaccaaggag ggggtagttg 4440 aaaaatccca gcttcctctg tgcctccact ctggccctaa atgctcctcc agcatctgtt 4500 tctcccttgg gactgtgtct catgtttgtg tgaatgtaga ccaggaaagg gggctgcaaa 4560 aatgttgagt ctaatgttcg taagcatcat agaaattcct gtcttcatat taagatgtac 4620 tgctttaaaa cacaactcca gagcccctcc ccaagctccc ctccccaagc tcctgaagac 4680 ccggtttctg agggagggaa attgctactt ggattgagag tagctggaat gtaagtgacc 4740 ccaggctttg ctcagggcct ttagcctatg tcccccccac ataaagagag cttctcagag 4800 cctgactgaa gagctgacgt tttgcttttt catatgccaa ttaaacccgg tctaaatcca 4860 aatgcttctc cagccatcca ggagtggctg tccttttcag tcttgtcttt tatataggta 4920 gctgaggggg aagatttaga agccttgcac tcactaaata gattaaacag agcaggcttg 4980 tttgttgaat tgctccaaag tccaacagac acacactgag caggtgtttt acactcacat 5040 tccctttttg ccccttaaat agaaagtgca ggtaaaggtt tatacaacaa gaaagcacat 5100 tgaaaataat ttgatactct aacaatccat taacatgtgt aggggttacg gtgaggatca 5160 tgtgttgtat tcgaaaaacg gggagaggga tgcttaattg gccctcgctt gctatttttt 5220 tctcatttct tcacaatagg accgtctttg gcagcagcaa aatgtatttc agtatggcag 5280 tctttcctct cttacattat tggtaagatt atactaacaa aatgtttccc cttgtacaat 5340 tatgctgtgt ttttaaaaaa cattgacctg tgtgttttta taaaagaaaa agtatgttgt 5400 gccttcttct taagaataaa gttttctaaa ggg 5433 <210> 127 <211> 2562 <212> DNA <213> Homo sapiens <400> 127 gggaatcggg agattcggga ccatggcacc tgtgcacggc gacgactgtg agataggggc 60 gagtgctctg tcagattcag ggagttttgt atcttctcga gcccggcgag aaaaaaaatc 120 aaagaagggg cgccaagaag ccctagaaag actgaaaaag gctaaagctg gtgagaagta 180 taaatatgaa gtcgaggact tcacaggtgt ttatgaagaa gttgatgaag aacagtattc 240 gaagctggtt caggcacgcc gggatgatga ctggattgtg gatgatgatg gtattggcta 300 tgtggaagat ggccgagaga tttttgatga tgaccttgaa gatgatgccc ttgatgctga 360 tgagaaagga aaagatggta aagcacgcaa taaagacaag aggaatgtaa agaagctcgc 420 agtgacaaaa ccgaacaaca ttaagtcaat gttcattgct tgtgctggaa agaaaactgc 480 agataaagct gtagacttgt ccaaggatgg tctgctaggt gacattctac aggatcttaa 540 cactgagaca cctcaaataa ctccaccacc tgtaatgata ctgaagaaga aaagatccat 600 tggagcttca ccgaatcctt tctctgtgca caccgccacg gcagttcctt caggaaaaat 660 tgcttcccct gtctccagaa aggagcctcc attaactcct gttcctctta aacgtgctga 720 atttgctggc gatgatgtac aggtcgagag tacagaagaa gagcaggagt cagaggcaat 780 ggagtttgaa gatggtgact ttgatgagcc catggaagtt gaagaggtgg acctggagcc 840 tatggctgcc aaggcttggg acaaagagag tgagccagca gaggaagtga aacaagaggc 900 ggattctggg aaagggaccg tgtcctactt aggaagtttt ctcccggatg tctcttgttg 960 ggacattgat caagaaggtg atagcagttt ctcagtgcaa gaagttcaag tggattccag 1020 tcacctccca ttggtaaaag gggcagatga ggaacaagta ttccactttt attggttgga 1080 tgcttatgag gatcagtaca accaaccagg tgtggtattt ctgtttggga aagtttggat 1140 tgaatcagcc gagacccatg tgagctgttg tgtcatggtg aaaaatatcg agcgaacgct 1200 ttacttcctt ccccgtgaaa tgaaaattga tctaaatacg gggaaagaaa caggaactcc 1260 aatttcaatg aaggatgttt atgaggaatt tgatgagaaa atagcaacaa aatataaaat 1320 tatgaagttc aagtctaagc cagtggaaaa gaactatgct tttgagatac ctgatgttcc 1380 agaaaaatct gagtacttgg aagttaaata ctcggctgaa atgccacagc ttcctcaaga 1440 tttgaaagga gaaacttttt ctcatgtatt tgggaccaac acatctagcc tggaactgtt 1500 cttgatgaac agaaagatca aaggaccttg ttggcttgaa gtaaaaagtc cacagctctt 1560 gaatcagcca gtcagttggt gtaaagttga ggcaatggct ttgaaaccag acctggtgaa 1620 tgtaattaag gatgtcagtc caccaccgct tgtcgtgatg gctttcagca tgaagacaat 1680 gcagaatgca aagaaccatc aaaatgaggt ttaaaaaata ggacagattt tgtacccatg 1740 ccttagatgt gttacttgcc tgaacttgca cagctttgct ttaagagaaa gttgttcttt 1800 ttggagggga aagaatacta attcactact aaactcttat agagaatgaa ttgaatttgt 1860 ctagtgttgg agttttttct taaagactta aattgctgaa cttattttta tttttgtcta 1920 ttaaattttt tacttaggag agcttcaaat ggacacagac agaataataa aatgaactcc 1980 ccataccaat cactcatatt cagcagttag caagattttg ttacacttgt ttatttccct 2040 cctttttttt cttcttgaag tattttaaag ctagtctcag acattgtgtc attttccctg 2100 tgaaccttgg tatgcttctc tcaaaatgtg gtatttctta tataatacca ttagcacacc 2160 taataacatt aacagtgact ccttggtata atctaaaata cccagtccat acttacatga 2220 ctctgtctct caagatgcct tttaaaactc agtttgtttg aatcaggatt cacacaagat 2280 tcgcagatgg tatttaatct atgtgcctct tgaatctctt ttaaacagga agaactcact 2340 cctactctcc agttttttta atgacattga ataattaaag aatcattgtt ggttgtcttg 2400 taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2460 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2520 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa 2562 <210> 128 <211> 2187 <212> DNA <213> Homo sapiens <400> 128 gaattccggc ttgggcgcag gtcggagctg ggtgggccgg ctccccggcc tggcttgggc 60 gaccatgtcc gcatccgccc agcagctggc ggaggagctg cagatcttcg gcctagactg 120 cgaggaggct ctaattgaga aattggtaga gctttgtgtt cagtatggac agaatgagga 180 gggaatggta ggcgagctta tagccttctg caccagcaca cataaagttg gccttacctc 240 agagatcctg aactcttttg agcatgagtt tctgagcaaa agattatcga aagccaggca 300 tagtacctgc aaggacagtg gccatgcagg agctagagac attgtttcca ttcaagagct 360 aattgaagtg gaagaagaag aggaaatcct cttgaactct tacaccacac cttcaaaggg 420 ttctcagaag cgagctatct ctaccccaga aaccccccta acaaaaagga gtgtgtcaac 480 tcgtagcccc catcagctac tctcaccgtc aagtttctct ccaagtgcta ctccctccca 540 gaaatacaac tcacgaagta accgaggaga agtggttacc tccttcggct tagcacaggg 600 agtatcttgg tctgggagag gaggagctgg aaacatcagc ctgaaggtct tgggatgtcc 660 agaggcacta actgggagct acaaatccat gtttcagaag ctcccagaca ttcgagaagt 720 tctgacctgt aagatagaag aacttggcag cgaactcaag gaacattaca agattgaagc 780 tttcactcct ttgctagccc cagcacagga gcctgtcact ctgctgggcc agattggctg 840 tgatagcaac gggaagctga acaacaagtc agtgattctc gagggagacc gggaacattc 900 ctcgggtgct caaattccag tggatttatc tgagcttaag gaatattctc tgtttcctgg 960 acaggttgta attatggaag gaatcaacac cactggtagg aaacttgttg ccaccaaact 1020 ctacgagggt gtgccacttc cattttatca gcccactgaa gaggatgcag actttgagca 1080 aagcatggtc ctggttgcct gtggaccata caccacatct gacagcatca cgtatgaccc 1140 cctgcttgac ctgattgctg tcatcaacca tgaccggcca gatgtctgca tcctgtttgg 1200 ccctttcctg gagtctaagc atgaacaggt ggagaattgt ctactgacaa gtccatttga 1260 agacattttc aagcagtgtc tacgaacaat tattgaaggc acaagaagct ccggctccca 1320 ccttgtcttt gtcccgtcat tgagagatgt gcaccatgag cctgtgtacc cccagccgcc 1380 tttcagctac tccgatctgt ctcgagagga caaaaagcaa gtacagtttg tgtccgagcc 1440 ctgcagcctc tccataaacg gagtgatctt cggcttgaca tccacagatc tgcttttcca 1500 cctgggggcc gaggagatca gtagttcttc cggaacttca gacagattca gccgaatact 1560 caagcacatc ttgacccaga ggagctacta cccactctac ccgccccaag aagacatggc 1620 cattgactat gagtcgttct atgtttacgc acagctgcct gtcaccccag atgtcctcat 1680 catcccgtca gagctgaggt acttcgtgaa ggatgtcctc ggctgtgtct gtgtgaaccc 1740 tgggcgcctt accaaagggc aggtgggagg caccttcgcc cgactctacc ttaggaggcc 1800 ggcagcggac ggggcagaga ggcagagccc atgcattgct gtgcaggtcg tcaggatctg 1860 aggcttctgt cctctgctgt tctctgctgt gtgggccctt aaagtcttag ccaagagcca 1920 agacatagcc ctgtgacaag gtgaacagtt gggtgggaaa ggagagagga gccagccagg 1980 gaggggcagc tgcagtgacc aggcccagca ggaggacttg tgcagccggg cctgcctgtg 2040 agtggtgcct ctcctggaag aagctcttgc ttctcagtcc atgctccgtg tccagaagta 2100 agccagctgt ggatcccgcc cactcagaaa aggcgagaag gctttgtgat tttctacatg 2160 aatcaaacac agaaacaccg gaattcc 2187 <210> 129 <211> 2514 <212> DNA <213> Homo sapiens <400> 129 cctcgtgccg cagttctgcc accgtcactg agaagctcag cggtagcttt tgggaagcag 60 gacgttctca ccaggagagc gtcctctcga gatttctgct ccctccattc agggcgtttg 120 ggagccaccc cttcattttt taaaaaaagt atttctctgt gaccgacggc cggggccttc 180 tgacggtctg aggtcttgct tgggccagtc acctcctgtc acggtccgcg gaggggggaa 240 ggataagagg gcgaggagct catcgctcgc cacccccgtg ggcttcttgg gcgcaggtcg 300 gagctgggtg ggccggctcc ccggcccctg gcttgggcga ccatgtccgc atccgcccag 360 cagctggcgg aggagctgca gatcttcggc ctagactgcg aggaggctct aattgagaaa 420 ttggtagagc tttgtgttca gtatggacag aatgaggagg gaatggtagg cgagcttata 480 gccttctgca ccagcacaca taaagttggc cttacctcag agatcctgaa ctcttttgag 540 catgagtttc tgagcaaaag attatcgaaa gccaggcata gtacctgcaa ggacagtggc 600 catgcaggag ctagagacat tgtttccatt caagagctaa ttgaagtgga agaagaagag 660 gaaatcctct tgaactctta caccacacct tcaaagggtt ctcagaagcg agctatctct 720 accccagaaa cccccctaac aaaaaggagt gtgtcaactc gtagccccca tcagctactc 780 tcaccgtcaa gtttctctcc aagtgctact ccctcccaga aatacaactc acgaagtaac 840 cgaggagaag tggttacctc cttcggctta gcacagggag tatcttggtc tgggagagga 900 ggagctggaa acatcagcct gaaggtcttg ggatgtccag aggcactaac tgggagctac 960 aaatccatgt ttcagaagct cccagacatt cgagaagttc tgacctgtaa gatagaagaa 1020 cttggcagcg aactcaagga acattacaag attgaagctt tcactccttt gctagcccca 1080 gcacaggagc ctgtcactct gctgggccag attggctgtg atagcaacgg gaagctgaac 1140 aacaagtcag tgattctcga gggagaccgg gaacattcct cgggtgctca aattccagtg 1200 gatttatctg agcttaagga atattctctg tttcctggac aggttgtaat tatggaagga 1260 atcaacacca ctggtaggaa acttgttgcc accaaactct acgagggtgt gccacttcca 1320 ttttatcagc ccactgaaga ggatgcagac tttgagcaaa gcatggtcct ggttgcctgt 1380 ggaccataca ccacatctga cagcatcacg tatgaccccc tgcttgacct gattgctgtc 1440 atcaaccatg accggccaga tgtctgcatc ctgtttggcc ctttcctgga tgctaagcat 1500 gaacaggtgg agaattgtct actgacaagt ccatttgaag acattttcaa gcagtgtcta 1560 cgaacaatta ttgaaggcac aagaagctcc ggctcccacc ttgtctttgt cccgtcattg 1620 agagatgtgc accatgagcc tgtgtacccc cagccgcctt tcagctactc cgatctgtct 1680 cgagaggaca aaaagcaagt acagtttgtg tccgagccct gcagcctctc cataaacgga 1740 gtgatcttcg gcttgacatc cacagatctg cttttccacc tgggggccga ggagatcagt 1800 agttcttccg gaacttcaga cagattcagc cgaatactca agcacatctt gacccagagg 1860 agctactacc cactctaccc gccccaagaa gacatggcca ttgactatga gtcgttctat 1920 gtttacgcac agctgcctgt caccccagat gtcctcatca tcccgtcaga gctgaggtac 1980 ttcgtgaagg atgtcctcgg ctgtgtctgt gtgaaccctg ggcgccttac caaagggcag 2040 gtgggaggca ccttcgcccg actctacctt aggaggccgg cagcggacgg ggcagagagg 2100 cagagcccat gcattgctgt gcaggtcgtc aggatctgag gcttctgtcc tctgctgttc 2160 tctgctgtgt gggcccttaa agtcttagcc aagagccaag acatagccct gtgacaaggt 2220 gaacagttgg gtgggaaagg agagaggagc cagccaggga ggggcagctg cagtgaccag 2280 gcccagcagg gaggacttgt gcagccgggc ctgcctctga gtggtgcctc tcctggaagg 2340 aagctcttgc ttctcagtcc atgctccgtg tccagaagta agccagctgt ggatcccgcc 2400 cactcagaaa aggcgagaag gctttgtgat tttctacatg aatcaaacac agaaacaact 2460 tttggagaaa ttaaattctg agtgtgaaaa aaaaaaaaaa aaaaaaaaaa aaaa 2514 <210> 130 <211> 2514 <212> DNA <213> Homo sapiens <400> 130 cctcgtgccg cagttctgcc accgtcactg agaagctcag cggtagcttt tgggaagcag 60 gacgttctca ccaggagagc gtcctctcga gatttctgct ccctccattc agggcgtttg 120 ggagccaccc cttcattttt taaaaaaagt atttctctgt gaccgacggc cggggccttc 180 tgacggtctg aggtcttgct tgggccagtc acctcctgtc acggtccgcg gaggggggaa 240 ggataagagg gcgaggagct catcgctcgc cacccccgtg ggcttcttgg gcgcaggtcg 300 gagctgggtg ggccggctcc ccggcccctg gcttgggcga ccatgtccgc atccgcccag 360 cagctggcgg aggagctgca gatcttcggc ctagactgcg aggaggctct aattgagaaa 420 ttggtagagc tttgtgttca gtatggacag aatgaggagg gaatggtagg cgagcttata 480 gccttctgca ccagcacaca taaagttggc cttacctcag agatcctgaa ctcttttgag 540 catgagtttc tgagcaaaag attatcgaaa gccaggcata gtacctgcaa ggacagtggc 600 catgcaggag ctagagacat tgtttccatt caagagctaa ttgaagtgga agaagaagag 660 gaaatcctct tgaactctta caccacacct tcaaagggtt ctcagaagcg agctatctct 720 accccagaaa cccccctaac aaaaaggagt gtgtcaactc gtagccccca tcagctactc 780 tcaccgtcaa gtttctctcc aagtgctact ccctcccaga aatacaactc acgaagtaac 840 cgaggagaag tggttacctc cttcggctta gcacagggag tatcttggtc tgggagagga 900 ggagctggaa acatcagcct gaaggtcttg ggatgtccag aggcactaac tgggagctac 960 aaatccatgt ttcagaagct cccagacatt cgagaagttc tgacctgtaa gatagaagaa 1020 cttggcagcg aactcaagga acattacaag attgaagctt tcactccttt gctagcccca 1080 gcacaggagc ctgtcactct gctgggccag attggctgtg atagcaacgg gaagctgaac 1140 aacaagtcag tgattctcga gggagaccgg gaacattcct cgggtgctca aattccagtg 1200 gatttatctg agcttaagga atattctctg tttcctggac aggttgtaat tatggaagga 1260 atcaacacca ctggtaggaa acttgttgcc accaaactct acgagggtgt gccacttcca 1320 ttttatcagc ccactgaaga ggatgcagac tttgagcaaa gcatggtcct ggttgcctgt 1380 ggaccataca ccacatctga cagcatcacg tatgaccccc tgcttgacct gattgctgtc 1440 atcaaccatg accggccaga tgtctgcatc ctgtttggcc ctttcctgga tgctaagcat 1500 gaacaggtgg agaattgtct actgacaagt ccatttgaag acattttcaa gcagtgtcta 1560 cgaacaatta ttgaaggcac aagaagctcc ggctcccacc ttgtctttgt cccgtcattg 1620 agagatgtgc accatgagcc tgtgtacccc cagccgcctt tcagctactc cgatctgtct 1680 cgagaggaca aaaagcaagt acagtttgtg tccgagccct gcagcctctc cataaacgga 1740 gtgatcttcg gcttgacatc cacagatctg cttttccacc tgggggccga ggagatcagt 1800 agttcttccg gaacttcaga cagattcagc cgaatactca agcacatctt gacccagagg 1860 agctactacc cactctaccc gccccaagaa gacatggcca ttgactatga gtcgttctat 1920 gtttacgcac agctgcctgt caccccagat gtcctcatca tcccgtcaga gctgaggtac 1980 ttcgtgaagg atgtcctcgg ctgtgtctgt gtgaaccctg ggcgccttac caaagggcag 2040 gtgggaggca ccttcgcccg actctacctt aggaggccgg cagcggacgg ggcagagagg 2100 cagagcccat gcattgctgt gcaggtcgtc aggatctgag gcttctgtcc tctgctgttc 2160 tctgctgtgt gggcccttaa agtcttagcc aagagccaag acatagccct gtgacaaggt 2220 gaacagttgg gtgggaaagg agagaggagc cagccaggga ggggcagctg cagtgaccag 2280 gcccagcagg gaggacttgt gcagccgggc ctgcctctga gtggtgcctc tcctggaagg 2340 aagctcttgc ttctcagtcc atgctccgtg tccagaagta agccagctgt ggatcccgcc 2400 cactcagaaa aggcgagaag gctttgtgat tttctacatg aatcaaacac agaaacaact 2460 tttggagaaa ttaaattctg agtgtgaaaa aaaaaaaaaa aaaaaaaaaa aaaa 2514 <210> 131 <211> 2514 <212> DNA <213> Homo sapiens <400> 131 cctcgtgccg cagttctgcc accgtcactg agaagctcag cggtagcttt tgggaagcag 60 gacgttctca ccaggagagc gtcctctcga gatttctgct ccctccattc agggcgtttg 120 ggagccaccc cttcattttt taaaaaaagt atttctctgt gaccgacggc cggggccttc 180 tgacggtctg aggtcttgct tgggccagtc acctcctgtc acggtccgcg gaggggggaa 240 ggataagagg gcgaggagct catcgctcgc cacccccgtg ggcttcttgg gcgcaggtcg 300 gagctgggtg ggccggctcc ccggcccctg gcttgggcga ccatgtccgc atccgcccag 360 cagctggcgg aggagctgca gatcttcggc ctagactgcg aggaggctct aattgagaaa 420 ttggtagagc tttgtgttca gtatggacag aatgaggagg gaatggtagg cgagcttata 480 gccttctgca ccagcacaca taaagttggc cttacctcag agatcctgaa ctcttttgag 540 catgagtttc tgagcaaaag attatcgaaa gccaggcata gtacctgcaa ggacagtggc 600 catgcaggag ctagagacat tgtttccatt caagagctaa ttgaagtgga agaagaagag 660 gaaatcctct tgaactctta caccacacct tcaaagggtt ctcagaagcg agctatctct 720 accccagaaa cccccctaac aaaaaggagt gtgtcaactc gtagccccca tcagctactc 780 tcaccgtcaa gtttctctcc aagtgctact ccctcccaga aatacaactc acgaagtaac 840 cgaggagaag tggttacctc cttcggctta gcacagggag tatcttggtc tgggagagga 900 ggagctggaa acatcagcct gaaggtcttg ggatgtccag aggcactaac tgggagctac 960 aaatccatgt ttcagaagct cccagacatt cgagaagttc tgacctgtaa gatagaagaa 1020 cttggcagcg aactcaagga acattacaag attgaagctt tcactccttt gctagcccca 1080 gcacaggagc ctgtcactct gctgggccag attggctgtg atagcaacgg gaagctgaac 1140 aacaagtcag tgattctcga gggagaccgg gaacattcct cgggtgctca aattccagtg 1200 gatttatctg agcttaagga atattctctg tttcctggac aggttgtaat tatggaagga 1260 atcaacacca ctggtaggaa acttgttgcc accaaactct acgagggtgt gccacttcca 1320 ttttatcagc ccactgaaga ggatgcagac tttgagcaaa gcatggtcct ggttgcctgt 1380 ggaccataca ccacatctga cagcatcacg tatgaccccc tgcttgacct gattgctgtc 1440 atcaaccatg accggccaga tgtctgcatc ctgtttggcc ctttcctgga tgctaagcat 1500 gaacaggtgg agaattgtct actgacaagt ccatttgaag acattttcaa gcagtgtcta 1560 cgaacaatta ttgaaggcac aagaagctcc ggctcccacc ttgtctttgt cccgtcattg 1620 agagatgtgc accatgagcc tgtgtacccc cagccgcctt tcagctactc cgatctgtct 1680 cgagaggaca aaaagcaagt acagtttgtg tccgagccct gcagcctctc cataaacgga 1740 gtgatcttcg gcttgacatc cacagatctg cttttccacc tgggggccga ggagatcagt 1800 agttcttccg gaacttcaga cagattcagc cgaatactca agcacatctt gacccagagg 1860 agctactacc cactctaccc gccccaagaa gacatggcca ttgactatga gtcgttctat 1920 gtttacgcac agctgcctgt caccccagat gtcctcatca tcccgtcaga gctgaggtac 1980 ttcgtgaagg atgtcctcgg ctgtgtctgt gtgaaccctg ggcgccttac caaagggcag 2040 gtgggaggca ccttcgcccg actctacctt aggaggccgg cagcggacgg ggcagagagg 2100 cagagcccat gcattgctgt gcaggtcgtc aggatctgag gcttctgtcc tctgctgttc 2160 tctgctgtgt gggcccttaa agtcttagcc aagagccaag acatagccct gtgacaaggt 2220 gaacagttgg gtgggaaagg agagaggagc cagccaggga ggggcagctg cagtgaccag 2280 gcccagcagg gaggacttgt gcagccgggc ctgcctctga gtggtgcctc tcctggaagg 2340 aagctcttgc ttctcagtcc atgctccgtg tccagaagta agccagctgt ggatcccgcc 2400 cactcagaaa aggcgagaag gctttgtgat tttctacatg aatcaaacac agaaacaact 2460 tttggagaaa ttaaattctg agtgtgaaaa aaaaaaaaaa aaaaaaaaaa aaaa 2514 <210> 132 <211> 2514 <212> DNA <213> Homo sapiens <400> 132 cctcgtgccg cagttctgcc accgtcactg agaagctcag cggtagcttt tgggaagcag 60 gacgttctca ccaggagagc gtcctctcga gatttctgct ccctccattc agggcgtttg 120 ggagccaccc cttcattttt taaaaaaagt atttctctgt gaccgacggc cggggccttc 180 tgacggtctg aggtcttgct tgggccagtc acctcctgtc acggtccgcg gaggggggaa 240 ggataagagg gcgaggagct catcgctcgc cacccccgtg ggcttcttgg gcgcaggtcg 300 gagctgggtg ggccggctcc ccggcccctg gcttgggcga ccatgtccgc atccgcccag 360 cagctggcgg aggagctgca gatcttcggc ctagactgcg aggaggctct aattgagaaa 420 ttggtagagc tttgtgttca gtatggacag aatgaggagg gaatggtagg cgagcttata 480 gccttctgca ccagcacaca taaagttggc cttacctcag agatcctgaa ctcttttgag 540 catgagtttc tgagcaaaag attatcgaaa gccaggcata gtacctgcaa ggacagtggc 600 catgcaggag ctagagacat tgtttccatt caagagctaa ttgaagtgga agaagaagag 660 gaaatcctct tgaactctta caccacacct tcaaagggtt ctcagaagcg agctatctct 720 accccagaaa cccccctaac aaaaaggagt gtgtcaactc gtagccccca tcagctactc 780 tcaccgtcaa gtttctctcc aagtgctact ccctcccaga aatacaactc acgaagtaac 840 cgaggagaag tggttacctc cttcggctta gcacagggag tatcttggtc tgggagagga 900 ggagctggaa acatcagcct gaaggtcttg ggatgtccag aggcactaac tgggagctac 960 aaatccatgt ttcagaagct cccagacatt cgagaagttc tgacctgtaa gatagaagaa 1020 cttggcagcg aactcaagga acattacaag attgaagctt tcactccttt gctagcccca 1080 gcacaggagc ctgtcactct gctgggccag attggctgtg atagcaacgg gaagctgaac 1140 aacaagtcag tgattctcga gggagaccgg gaacattcct cgggtgctca aattccagtg 1200 gatttatctg agcttaagga atattctctg tttcctggac aggttgtaat tatggaagga 1260 atcaacacca ctggtaggaa acttgttgcc accaaactct acgagggtgt gccacttcca 1320 ttttatcagc ccactgaaga ggatgcagac tttgagcaaa gcatggtcct ggttgcctgt 1380 ggaccataca ccacatctga cagcatcacg tatgaccccc tgcttgacct gattgctgtc 1440 atcaaccatg accggccaga tgtctgcatc ctgtttggcc ctttcctgga tgctaagcat 1500 gaacaggtgg agaattgtct actgacaagt ccatttgaag acattttcaa gcagtgtcta 1560 cgaacaatta ttgaaggcac aagaagctcc ggctcccacc ttgtctttgt cccgtcattg 1620 agagatgtgc accatgagcc tgtgtacccc cagccgcctt tcagctactc cgatctgtct 1680 cgagaggaca aaaagcaagt acagtttgtg tccgagccct gcagcctctc cataaacgga 1740 gtgatcttcg gcttgacatc cacagatctg cttttccacc tgggggccga ggagatcagt 1800 agttcttccg gaacttcaga cagattcagc cgaatactca agcacatctt gacccagagg 1860 agctactacc cactctaccc gccccaagaa gacatggcca ttgactatga gtcgttctat 1920 gtttacgcac agctgcctgt caccccagat gtcctcatca tcccgtcaga gctgaggtac 1980 ttcgtgaagg atgtcctcgg ctgtgtctgt gtgaaccctg ggcgccttac caaagggcag 2040 gtgggaggca ccttcgcccg actctacctt aggaggccgg cagcggacgg ggcagagagg 2100 cagagcccat gcattgctgt gcaggtcgtc aggatctgag gcttctgtcc tctgctgttc 2160 tctgctgtgt gggcccttaa agtcttagcc aagagccaag acatagccct gtgacaaggt 2220 gaacagttgg gtgggaaagg agagaggagc cagccaggga ggggcagctg cagtgaccag 2280 gcccagcagg gaggacttgt gcagccgggc ctgcctctga gtggtgcctc tcctggaagg 2340 aagctcttgc ttctcagtcc atgctccgtg tccagaagta agccagctgt ggatcccgcc 2400 cactcagaaa aggcgagaag gctttgtgat tttctacatg aatcaaacac agaaacaact 2460 tttggagaaa ttaaattctg agtgtgaaaa aaaaaaaaaa aaaaaaaaaa aaaa 2514 <210> 133 <211> 2514 <212> DNA <213> Homo sapiens <400> 133 cctcgtgccg cagttctgcc accgtcactg agaagctcag cggtagcttt tgggaagcag 60 gacgttctca ccaggagagc gtcctctcga gatttctgct ccctccattc agggcgtttg 120 ggagccaccc cttcattttt taaaaaaagt atttctctgt gaccgacggc cggggccttc 180 tgacggtctg aggtcttgct tgggccagtc acctcctgtc acggtccgcg gaggggggaa 240 ggataagagg gcgaggagct catcgctcgc cacccccgtg ggcttcttgg gcgcaggtcg 300 gagctgggtg ggccggctcc ccggcccctg gcttgggcga ccatgtccgc atccgcccag 360 cagctggcgg aggagctgca gatcttcggc ctagactgcg aggaggctct aattgagaaa 420 ttggtagagc tttgtgttca gtatggacag aatgaggagg gaatggtagg cgagcttata 480 gccttctgca ccagcacaca taaagttggc cttacctcag agatcctgaa ctcttttgag 540 catgagtttc tgagcaaaag attatcgaaa gccaggcata gtacctgcaa ggacagtggc 600 catgcaggag ctagagacat tgtttccatt caagagctaa ttgaagtgga agaagaagag 660 gaaatcctct tgaactctta caccacacct tcaaagggtt ctcagaagcg agctatctct 720 accccagaaa cccccctaac aaaaaggagt gtgtcaactc gtagccccca tcagctactc 780 tcaccgtcaa gtttctctcc aagtgctact ccctcccaga aatacaactc acgaagtaac 840 cgaggagaag tggttacctc cttcggctta gcacagggag tatcttggtc tgggagagga 900 ggagctggaa acatcagcct gaaggtcttg ggatgtccag aggcactaac tgggagctac 960 aaatccatgt ttcagaagct cccagacatt cgagaagttc tgacctgtaa gatagaagaa 1020 cttggcagcg aactcaagga acattacaag attgaagctt tcactccttt gctagcccca 1080 gcacaggagc ctgtcactct gctgggccag attggctgtg atagcaacgg gaagctgaac 1140 aacaagtcag tgattctcga gggagaccgg gaacattcct cgggtgctca aattccagtg 1200 gatttatctg agcttaagga atattctctg tttcctggac aggttgtaat tatggaagga 1260 atcaacacca ctggtaggaa acttgttgcc accaaactct acgagggtgt gccacttcca 1320 ttttatcagc ccactgaaga ggatgcagac tttgagcaaa gcatggtcct ggttgcctgt 1380 ggaccataca ccacatctga cagcatcacg tatgaccccc tgcttgacct gattgctgtc 1440 atcaaccatg accggccaga tgtctgcatc ctgtttggcc ctttcctgga tgctaagcat 1500 gaacaggtgg agaattgtct actgacaagt ccatttgaag acattttcaa gcagtgtcta 1560 cgaacaatta ttgaaggcac aagaagctcc ggctcccacc ttgtctttgt cccgtcattg 1620 agagatgtgc accatgagcc tgtgtacccc cagccgcctt tcagctactc cgatctgtct 1680 cgagaggaca aaaagcaagt acagtttgtg tccgagccct gcagcctctc cataaacgga 1740 gtgatcttcg gcttgacatc cacagatctg cttttccacc tgggggccga ggagatcagt 1800 agttcttccg gaacttcaga cagattcagc cgaatactca agcacatctt gacccagagg 1860 agctactacc cactctaccc gccccaagaa gacatggcca ttgactatga gtcgttctat 1920 gtttacgcac agctgcctgt caccccagat gtcctcatca tcccgtcaga gctgaggtac 1980 ttcgtgaagg atgtcctcgg ctgtgtctgt gtgaaccctg ggcgccttac caaagggcag 2040 gtgggaggca ccttcgcccg actctacctt aggaggccgg cagcggacgg ggcagagagg 2100 cagagcccat gcattgctgt gcaggtcgtc aggatctgag gcttctgtcc tctgctgttc 2160 tctgctgtgt gggcccttaa agtcttagcc aagagccaag acatagccct gtgacaaggt 2220 gaacagttgg gtgggaaagg agagaggagc cagccaggga ggggcagctg cagtgaccag 2280 gcccagcagg gaggacttgt gcagccgggc ctgcctctga gtggtgcctc tcctggaagg 2340 aagctcttgc ttctcagtcc atgctccgtg tccagaagta agccagctgt ggatcccgcc 2400 cactcagaaa aggcgagaag gctttgtgat tttctacatg aatcaaacac agaaacaact 2460 tttggagaaa ttaaattctg agtgtgaaaa aaaaaaaaaa aaaaaaaaaa aaaa 2514 <210> 134 <211> 2490 <212> DNA <213> Homo sapiens <400> 134 tgcggtagct tttgggaagc aggacgttct caccaggaga gcgtcctctc gagatttctg 60 ctccctccat tcagggcgtt tgggagccac cccttcattt tttaaaaaaa gtatttctct 120 gtgaccgacg gccggggcct tctgacggtc tgaggtcttg cttgggccag tcacctcctg 180 tcacggtccg cggagggggg aaggataaga gggcgaggag ctcatcgctc gccacccccg 240 tgggcttctt gggcgcaggt cggagctggg tgggccggct ccccggcccc tggcttgggc 300 gaccatgtcc gcatccgccc agcagctggc ggaggagctg cagatcttcg gcctagactg 360 cgaggaggct ctaattgaga aattggtaga gctttgtgtt cagtatggac agaatgagga 420 gggaatggta ggcgagctta tagccttctg caccagcaca cataaagttg gccttacctc 480 agagatcctg aactcttttg agcatgagtt tctgagcaaa agattatcga aagccaggca 540 tagtacctgc aaggacagtg gccatgcagg agctagagac attgtttcca ttcaagagct 600 aattgaagtg gaagaagaag aggaaatcct cttgaactct tacaccacac cttcaaaggg 660 ttctcagaag cgagctatct ctaccccaga aaccccccta acaaaaagga gtgtgtcaac 720 tcgtagcccc catcagctac tctcaccgtc aagtttctct ccaagtgcta ctccctccca 780 gaaatacaac tcacgaagta accgaggaga agtggttacc tccttcggct tagcacaggg 840 agtatcttgg tctgggagag gaggagctgg aaacatcagc ctgaaggtct tgggatgtcc 900 agaggcacta actgggagct acaaatccat gtttcagaag ctcccagaca ttcgagaagt 960 tctgacctgt aagatagaag aacttggcag cgaactcaag gaacattaca agattgaagc 1020 tttcactcct ttgctagccc cagcacagga gcctgtcact ctgctgggcc agattggctg 1080 tgatagcaac ggggagctga acaacaagtc agtgattctc gagggagacc gggaacattc 1140 ctcgggtgct caaattccag tggatttatc tgagcttaag gaatattctc tgtttcctgg 1200 acaggttgta attatggaag gaatcaacac cactggtagg aaacttgttg ccaccaaact 1260 ctacgagggt gtgccacttc cattttatca gcccactgaa gaggatgcag actttgagca 1320 aagcatggtc ctggttgcct gtggaccata caccacatct gacagcatca cgtatgaccc 1380 cctgcttgac ctgattgctg tcatcaacca tgaccggcca gatgtctgca tcctgtttgg 1440 ccctttcctg gatgctaagc atgaacaggt ggagaattgt ctactgacaa gtccatttga 1500 agacattttc aagcagtgtc tacgaacaat tattgaaggc acaagaagct ccggctccca 1560 ccttgtcttt gtcccgtcat tgagagatgt gcaccatgag cctgtgtacc cccagccgcc 1620 tttcagctac tccgatctgt ctcgagagga caaaaagcaa gtacagtttg tgtccgagcc 1680 ctgcagcctc tccataaacg gagtgatctt cggcttgaca tccacagatc tgcttttcca 1740 cctgggggcc gaggagatca gtagttcttc cggaacttca gacagattca gccgaatact 1800 caagcacatc ttgacccaga ggagctacta cccactctac ccgccccaag aagacatggc 1860 cattgactat gagtcgttct atgtttacgc acagctgcct gtcaccccag atgtcctcat 1920 catcccgtca gagctgaggt acttcgtgaa ggatgtcctc ggctgtgtct gtgtgaaccc 1980 tgggcgcctt accaaagggc aggtgggagg caccttcgcc cgactctacc ttaggaggcc 2040 ggcagcggac ggggcagaga ggcagagccc atgcattgct gtgcaggtcg tcaggatctg 2100 aggcttctgt cctctgctgt tctctgctgt gtgggccctt aaagtcttag ccaagagcca 2160 agacatagcc ctgtgacaag gtgaacagtt gggtgggaaa ggagagagga gccagccagg 2220 gaggggcagc tgcagtgacc aggcccagca gggaggactt gtgcagccgg gcctgcctct 2280 gagtggtgcc tctcctggaa ggaagctctt gcttctcagt ccatgctccg tgtccagaag 2340 taagccagct gtggatcccg cccactcaga aaaggcgaga aggctttgtg attttctaca 2400 tgaatcaaac acagaaacaa cttttggaga aattaaattc tgagtgtgac ttctgaaaaa 2460 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2490 <210> 135 <211> 1925 <212> DNA <213> Homo sapiens <400> 135 ttgactaaat tatctaacct ttctgttgct tgttttcctc atctgtaaaa tggatacagt 60 aatgtccacc cgatggttgt tgcaaggatt aaatgagtta atacatataa aatgcctaag 120 aatacatttt agaacagtgc atggtattta gtaagctcaa gaaatgttag ctattattaa 180 gtagttatag ctgcccaaag atgcagtggg ctgccctggg gtggtgagga cagggtgggg 240 taggcatcca ggggcaagtt cccctacact agagatgctc acacttaggc agcctcctag 300 gaaggctcaa gtgctgggtg gataggtgga caagatgccc tttcagagtt cttccatcct 360 gagagtcagt gatgacgcgg tagtcacctc agggtcaaag caatgccctg ccaagaaatg 420 tatttgttgt ttgcagtttg ttttgctatt caccctatcg acttcagatt ttgagctcct 480 gctccaaaga ctgtcattct tatgctgtga ccttcctttg gtaggagcct gtcactctgc 540 tgggccagat tggctgtgat agcaacggga agctgaacaa caagtcagtg attctcgagg 600 gagaccggga acattcctcg ggtgctcaaa ttccagtgga tttatctgag cttaaggaat 660 attctctgtt tcctggacag gttgtaatta tggaaggaat caacaccact ggtaggaaac 720 ttgttgccac caaactctac gagggtgtgc cacttccatt ttatcagccc actgaagagg 780 atgcagactt tgagcaaagc atggtcctgg ttgcctgtgg accatacacc acatctgaca 840 gcatcacgta tgaccccctg cttgacctga ttgctgtcat caaccatgac cggccagatg 900 tctgcatcct gtttggccct ttcctggatg ctaagcatga acaggtggag aattgtctac 960 tgacaagtcc atttgaagac attttcaagc agtgtctacg aacaattatt gaaggcacaa 1020 gaagctccgg ctcccacctt gtctttgtcc cgtcattgag agatgtgcac catgagcctg 1080 tgtaccccca gccgcctttc agctactccg atctgtctcg agaggacaaa aagcaagtac 1140 agtttgtgtc cgagccctgc agcctctcca taaacggagt gatcttcggc ttgacatcca 1200 cagatctgct tttccacctg ggggccgagg agatcagtag ttcttccgga acttcagaca 1260 gattcagccg aatactcaag cacatcttga cccagaggag ctactaccca ctctacccgc 1320 cccaagaaga catggccatt gactatgagt cgttctatgt ttacgcacag ctgcctgtca 1380 ccccagatgt cctcatcatc ccgtcagagc tgaggtactt cgtgaaggat gtcctcggct 1440 gtgtctgtgt gaaccctggg cgccttacca aagggcaggt gggaggcacc ttcgcccgac 1500 tctaccttag gaggccggca gcggacgggg cagagaggca gagcccatgc attgctgtgc 1560 aggtcgtcag gatctgaggc ttctgtcctc tgctgttctc tgctgtgtgg gcccttaaag 1620 tcttagccaa gagccaagac atagccctgt gacaaggtga acagttgggt gggaaaggag 1680 agaggagcca gccagggagg ggcagctgca gtgaccaggc ccagcaggga ggacttgtgc 1740 agccgggcct gcctctgagt ggtgcctctc ctggaaggaa gctcttgctt ctcagtccat 1800 gctccgtgtc cagaagtaag ccagctgtgg atcccgccca ctcagaaaag gcgagaaggc 1860 tttgtgattt tctacatgaa tcaaacacag aaacaacttt tggagaaatt aaattctgag 1920 tgtga 1925 <210> 136 <211> 2353 <212> DNA <213> Homo sapiens <400> 136 ggtttcatat gaactctccc gccacccggg aacagtggct gccaccgttt gtgttttccc 60 gagtttgaat tcttgcaggt gaccaagatg gagttttctg gaagaaagtg gaggaagctg 120 aggttggcag gtgaccagag gaatgcttcc taccctcatt gccttcagtt ttacttgcag 180 ccaccttctg aaaacatatc tttaatagaa tttgaaaact tggctattga tagagttaaa 240 ttgttaaaat cagttgaaaa tcttggagtg agctatgtga aaggaactga acaataccag 300 agtaagttgg agagtgagct tcggaagctc aagttttcct acagagaaaa cttagaagat 360 gaatatgaac cacgaagaag agatcatatt tctcatttta ttttgcggct tgcttattgc 420 cagtctgaag aacttagacg ctggttcatt caacaagaaa tggatctcct tcgatttaga 480 tttagtattt tacccaagga taaaattcag gatttcttaa aggatagcca attgcagttt 540 gaggctataa gtgatgaaga gaagactctt cgagaacagg agattgttgc ctcatcacca 600 agtttaagtg gacttaagtt ggggttcgag tccatttata agatcccttt tgctgatgct 660 ctggatttgt ttcgaggaag gaaagtctat ttggaagatg gctttgctta cgtaccactt 720 aaggacattg tggcaatcat cctgaatgaa tttagagcca aactgtccaa ggctttggca 780 ttaacagcca ggtccttgcc tgctgtgcag tctgatgaaa gacttcagcc tctgctcaat 840 cacctcagtc attcctacac tggccaagat tacagtaccc agggaaatgt tgggaagatt 900 tctttagatc agattgattt gctttctacc aaatccttcc caccttgcat gcgtcagtta 960 cataaagcct tgcgggaaaa tcaccatctt cgtcatggag gccgaatgca gtatggccta 1020 tttctgaagg gcattggttt aactttggaa caggcattgc agttctggaa gcaagaattt 1080 atcaaaggaa agatggatcc agacaagttt gataaaggtt actcttacaa catccgtcac 1140 agctttggaa aggaaggcaa gaggacagac tatacacctt tcagttgcct gaagattatt 1200 ctgtccaatc caccaagcca aggggattat catgggtgcc cattccgtca cagtgatcca 1260 gagctgctga agcaaaagtt gcagtcatac aagatctctc ctggagggat aagccagatt 1320 ttggatttag taaaggggac acattaccag gtagcctgtc aaaaatactt tgagatgata 1380 cacaatgtgg atgattgtgg cttttctttg aatcatccta atcagttctt ttgtgagagc 1440 caacgtattc taaatggtgg taaagacata aagaaggaac ctatccaacc agaaactcct 1500 caacccaaac caagtgtcca gaaaaccaag gatgcatcat ctgctctggc ctctttaaat 1560 tcctctctgg aaatggatat ggaaggacta gaagattact ttagtgaaga ttcttaggca 1620 gttttataac cctttttcct caatagcctg tttcctgttt ttaagatttt gcctttgttg 1680 ttgaaaaagg gtttcactct gtcaccaagg cttagtgcag tgacacaatt acagctgatt 1740 gcagccttga ccttcccagc tcaagtgatc ctcctacctc agcctcccaa gtagttagga 1800 ccacaggtgt gcacctcata tccagataat ttttttcaat ttttttttgt agaggtgggg 1860 ggtctcccta tgttgcccag gcagatctca gactcctggg ctcaagcgat cctcacacct 1920 cagcgtccca gagtgctggg attacggttg tgagccactg tgcctggcct tttttttttt 1980 ttttaacctt tttgtttaac ttctctcttc actgcatccc aatccatcta caggcatgca 2040 cacttattag gaaaggaggt ttgaggtaac aacagagact ttcactatat tttgctttga 2100 cagaaggaaa gaggaggagt ttctattaaa atctgtcact tgagtgatgt catttaagtc 2160 ctattttagg agataaaaac agctttgggg actggttaaa gtcccccaga aactacaata 2220 aagaacaact tttgttttaa ctcttaatca ctttgtaatt ttgactcaat ccttttctgg 2280 accatttttg ttaataaata tcaaagtgta aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2340 aaaaaaaaaa aaa 2353 <210> 137 <211> 2306 <212> DNA <213> Homo sapiens <400> 137 ggtttcatat gaactctccc gccacccggg aacagctggc tgccaccgtt tgtgttttcc 60 gagtttgtat tcttgcaggt gaccaagatg gagttttctg gaagaaagcg gaggaagctg 120 aggttggcag gtgaccagag gaatgcttcc taccctcatt gccttcagtt ttacttgcag 180 ccaccttctg aaaacatatc tttaacagaa tttgaaaact tggctattga tagagttaaa 240 ttgttaaaat cagttgaaaa tcttggagtg agctatgtga aaggaactga acaataccag 300 agtaagttgg agagtgagct tcggaagctc aagttttcct acagagagaa gctagaagat 360 gaatatgaac cacgaagaag agatcatatt tctcatttta ttttgcggct tgcttattgc 420 cagtctgaag aacttagacg ctggttcatt caacaagaaa tggatctcct tcgatttaga 480 tttagtattt tacccaagga taaaattcag gatttcttaa aggatagcca attgcagttt 540 gaggctataa gtgatgaaga gaagactctt cgagaacagg agattgttgc ctcatcacca 600 agtttaagtg gacttaagtt ggggttcgag tccatttata agatcccttt tgctgatgct 660 ctggatttgt ttcgaggaag gaaagtctat ttggaagatg gctttgctta cgtaccactt 720 aaggacattg tggcaatcat cctgaatgaa tttagagcca aactgtccaa ggctttggca 780 ttaacagcca ggtccttgcc tgctgtgcag tctgatgaaa gacttcagcc tctgctcaat 840 cacctcagtc attcctacac tggccaagat tacagtaccc agggaaatgt tgggaagatt 900 tctttagatc agattgattt gctttctacc aaatccttcc caccttgcat gcgtcagtta 960 cataaagcct tgcgggaaaa tcaccatctt cgtcatggag gccgaatgca gtatggccta 1020 tttctgaagg gcattggttt aactttggaa caggcattgc agttctggaa gcaagaattt 1080 atcaaaggaa agatggatcc agacaagttt gataaaggtt actcttacaa catccgtcac 1140 agctttggaa aggaaggcaa gaggacagac tatacacctt tcagttgcct gaagattatt 1200 ctgtccaatc caccaagcca aggggattat catgggtgcc cattccgtca cagtgatcca 1260 gagctgctga agcaaaagtt gcagtcatac aagatctctc ctggagggat aagccagatt 1320 ttggatttag taaaggggac acattaccag gtagcctgtc aaaaatactt tgagatgata 1380 cacaatgtgg atgattgtgg cttttctttg aatcatccta atcagttctt ttgtgagagc 1440 caacgtattc taaatggtgg taaagacata aagaaggaac ctatccaacc agaaactcct 1500 caacccaaac caagtgtcca gaaaaccaag gatgcatcat ctgctctggc ctctttaaat 1560 tcctctctgg aaatggatat ggaaggacta gaagattact ttagtgaaga ttcttaggca 1620 gttttataac cctttttcct caatagcctg tttcctgttt ttaagatttt gcctttgttg 1680 ttgaaaaagg gtttcactgt caccaaggct tagtgcagtg acacaattac agctgattgc 1740 agccttgacc ttcccagctc aagtgatcct cctacctcag cctcccaagt agttaggaca 1800 cacaggtgtg cacctcatat ccagataatt tttttcaatt tttttttgta gaggtggggg 1860 gtctccctat gttgcccagg cagatctcag actcctgggc tcaagcgatc ctcacacctc 1920 agcgtcccag agtgctggga ttacagttgt gagccactgt gcctggcctt tttttttttt 1980 taaccttttc gtttaacttc tctcttcact gcatcccaat ccatctacag gcatgcacac 2040 ttattaggaa aggaggtttg aggtaacaac agagactttc actatatttt gctttgacag 2100 aaggaaagag gaggagtttc tattaaaatc tgtcacttga gtgatgtcat ttaagtccta 2160 ttttaggaga taaaaacagc tttggggact ggttaaagtc ccccagaaac tacaataaag 2220 aacaactttt gttttaactc ttaatcactt tgtaattttg actcaatcct tttctggacc 2280 atttttgtta ataaatatca aagtgt 2306 <210> 138 <211> 902 <212> DNA <213> Homo sapiens <400> 138 ctcttccggt ttcatatgaa ctctcccgcc acccgggaac agtggctgcc accgtttgtg 60 ttttcccgag tttgaattct tgcaggtgac caagatggag ttttctggaa gaaagtggag 120 gaagctgagg ttggcaggtg accagaggaa tgcttcctac cctcattgcc ttcagtttta 180 cttgcagcca ccttctgaaa acatatcttt aatagaattt gaaaacttgg ctattgatag 240 agttaaattg ttaaaatcag ttgaaaatct tggagtgagc tatgtgaaag gaactgaaca 300 ataccagagt aagttggaga gtgagcttcg gaagctcaag ttttcctaca gagaaaactt 360 agaagatgaa tatgaaccac gaagaagaga tcatatttct cattttattt tgcggcttgc 420 ttattgccag tctgaagaac ttagacgctg gttcattcaa caagaaatgg atctccttcg 480 atttagattt agtattttac ccaaggataa aattcaggat ttcttaaagg atagccaatt 540 gcagtttgag gctgtaagta tatttttgta gttatttcta attgttctca ccattcattt 600 ttcccttctg tcttaagtgc tggtactaat gtgtagtgtg ttctctttac attctccaag 660 tacctgcctg aaacagtagc taatagcttt ggataacaat atatctttcc ttctctatga 720 ctagaagaaa aggactcctt aataacaaag tctcacactt acttgctctg ttaaatgtgt 780 gctttattaa agcacaagaa ggtttagttt ataaaggttc atctttaacc aaaattttgt 840 cggccaaaat aaagctaata atgtgttaaa ccaaaaaaaa aaaaaaaaaa aaaaaaaaaa 900 aa 902 <210> 139 <211> 2824 <212> DNA <213> Homo sapiens <400> 139 ggagctgttg cggggtccgc ggggaagtct tggcggtgga gccatggtcg gccaactgag 60 cgagggggcc attgcggcca tcatgcagaa gggggataca aacataaagc ccatcctcca 120 agtcatcaac atccgtccca ttactacggg gaatagtccg ccgcgttatc gactgctcat 180 gagtgatgga ttgaacactc tatcctcttt catgttggcg acacagttga accctctcgt 240 ggaggaagaa caattgtcca gcaactgtgt atgccagatt cacagattta ttgtgaacac 300 tctgaaagac ggaaggagag tagttatctt gatggaatta gaagttttga agtcagctga 360 agcagttgga gtgaagattg gcaatccagt gccctataat gaaggactcg ggcagccgca 420 agtagctcct ccagcgccag cagccagccc agcagcaagc agcaggcccc agccgcagaa 480 tggaagctcg ggaatgggtt ctactgtttc taaggcttat ggtgcttcaa agacatttgg 540 aaaagctgca ggtcccagcc tgtcacacac ttctggggga acacagtcca aagtggtgcc 600 cattgccagc ctcactcctt accagtccaa gtggaccatt tgtgctcgtg ttaccaacaa 660 aagtcagatc cgtacctgga gcaactcccg aggggaaggg aagcttttct ccctagaact 720 ggttgacgaa agtggtgaaa tccgagctac agctttcaat gagcaagtgg acaagttctt 780 tcctcttatt gaagtgaaca aggtgtatta tttctcgaaa ggcaccctga agattgctaa 840 caagcagttc acagctgtta aaaatgacta cgagatgacc ttcaataacg agacttccgt 900 catgccctgt gaggacgacc atcatttacc tacggttcag tttgatttca cggggattga 960 tgacctcgag aacaagtcga aagactcact tgtagacatc atcgggatct gcaagagcta 1020 tgaagacgcc actaaaatca cagtgaggtc taacaacaga gaagttgcca agaggaatat 1080 ctacttgatg gacacatctg ggaaggtggt gactgctaca ctgtgggggg aagatgctga 1140 taaatttgat ggttctagac agcccgtgtt ggctatcaaa ggagcccgag tctctgattt 1200 cggtggacgg agcctctccg tgctgtcttc aagcactatc attgcgaatc ctgacatccc 1260 agaggcctat aagcttcgtg gatggtttga cgcagaagga caagccttag atggtgtttc 1320 catctctgat ctaaagagcg gcggagtcgg agggagtaac accaactgga aaaccttgta 1380 tgaggtcaaa tccgagaacc tgggccaagg cgacaagccg gactacttta gttctgtggc 1440 cacagtggtg tatcttcgca aagagaactg catgtaccaa gcctgcccga ctcaggactg 1500 caataagaaa gtgattgatc aacagaatgg attgtaccgc tgtgagaagt gcgacaccga 1560 atttcccaat ttcaagtacc gcatgatcct gtcagtaaat attgcagatt ttcaagagaa 1620 tcagtgggtg acttgtttcc aggagtctgc tgaagctatc cttggacaaa atgctgctta 1680 tcttggggaa ttaaaagaca agaatgaaca ggcatttgaa gaagttttcc agaatgccaa 1740 cttccgatct ttcatattca gagtcagggt caaagtggag acctacaacg acgagtctcg 1800 aattaaggcc actgtgatgg acgtgaagcc cgtggactac agagagtatg gccgaaggct 1860 ggtcatgagc atcaggagaa gtgcattgat gtgagaggag cagtgccaat cgggcagaag 1920 tttgcaaata ggcagaatgg aatcgatttc ctcccacctc cgtgtgacga tcccatgtta 1980 gctacacagt gcagaggctc ttgatggtgg actaagcaat ttcctccctt gtgcgcatct 2040 cagaacccat cggtaggcaa aggaaaatac gctcaggtgg ttgtggtgta gactgtgtca 2100 ggcctacgga gtcagccagt ggctagcgca agaccagtca ctccctctgc cttcaggctt 2160 ctgtcaattt cattatcatc aagcaggaat tatgtcgtaa gtcactgacc ctaactgcag 2220 accatgaagt aaattatgta actaggtttt tgcttctcca gtggtgacca cccccccccc 2280 atccccgctc acaacttggg ttcttctcag cggggcgagc tgagaagcgg tcatgagcac 2340 ctggggattt tagtaagtgt gtcttcctag aattcgaagg ctctctcttt ctagaggtgc 2400 tacatagttg gtaatgcttg gaatggcaat agggtagaat gattaatcaa aggcatatct 2460 tctatatctg aagagtatcc ttccttcagg gtttaataga ctgagtcaga tgggtctgat 2520 attaatcaaa attgtctctt ctgaggaccg ctgataagca ttgacttgct gtcccctaag 2580 gaaatccgag cggctacaaa gcgtttcttt acttttcact tcaattaatg ctgcgcttcg 2640 cttggtgagt gcgtactttt tctacctgta cacattcctg cattcatgta ttttgttttt 2700 tttgactaaa gctatgttac atggaaagga ttttgaagcc ttttgtttcc cttgctttgt 2760 tttaataaac agtatattct ttggttgtga atcctaaaaa aaaaaaaaaa aaaaaaaaaa 2820 aaaa 2824 <210> 140 <211> 2824 <212> DNA <213> Homo sapiens <400> 140 ggagctgttg cggggtccgc ggggaagtct tggcggtgga gccatggtcg gccaactgag 60 cgagggggcc attgcggcca tcatgcagaa gggggataca aacataaagc ccatcctcca 120 agtcatcaac atccgtccca ttactacggg gaatagtccg ccgcgttatc gactgctcat 180 gagtgatgga ttgaacactc tatcctcttt catgttggcg acacagttga accctctcgt 240 ggaggaagaa caattgtcca gcaactgtgt atgccagatt cacagattta ttgtgaacac 300 tctgaaagac ggaaggagag tagttatctt gatggaatta gaagttttga agtcagctga 360 agcagttgga gtgaagattg gcaatccagt gccctataat gaaggactcg ggcagccgca 420 agtagctcct ccagcgccag cagccagccc agcagcaagc agcaggcccc agccgcagaa 480 tggaagctcg ggaatgggtt ctactgtttc taaggcttat ggtgcttcaa agacatttgg 540 aaaagctgca ggtcccagcc tgtcacacac ttctggggga acacagtcca aagtggtgcc 600 cattgccagc ctcactcctt accagtccaa gtggaccatt tgtgctcgtg ttaccaacaa 660 aagtcagatc cgtacctgga gcaactcccg aggggaaggg aagcttttct ccctagaact 720 ggttgacgaa agtggtgaaa tccgagctac agctttcaat gagcaagtgg acaagttctt 780 tcctcttatt gaagtgaaca aggtgtatta tttctcgaaa ggcaccctga agattgctaa 840 caagcagttc acagctgtta aaaatgacta cgagatgacc ttcaataacg agacttccgt 900 catgccctgt gaggacgacc atcatttacc tacggttcag tttgatttca cggggattga 960 tgacctcgag aacaagtcga aagactcact tgtagacatc atcgggatct gcaagagcta 1020 tgaagacgcc actaaaatca cagtgaggtc taacaacaga gaagttgcca agaggaatat 1080 ctacttgatg gacacatctg ggaaggtggt gactgctaca ctgtgggggg aagatgctga 1140 taaatttgat ggttctagac agcccgtgtt ggctatcaaa ggagcccgag tctctgattt 1200 cggtggacgg agcctctccg tgctgtcttc aagcactatc attgcgaatc ctgacatccc 1260 agaggcctat aagcttcgtg gatggtttga cgcagaagga caagccttag atggtgtttc 1320 catctctgat ctaaagagcg gcggagtcgg agggagtaac accaactgga aaaccttgta 1380 tgaggtcaaa tccgagaacc tgggccaagg cgacaagccg gactacttta gttctgtggc 1440 cacagtggtg tatcttcgca aagagaactg catgtaccaa gcctgcccga ctcaggactg 1500 caataagaaa gtgattgatc aacagaatgg attgtaccgc tgtgagaagt gcgacaccga 1560 atttcccaat ttcaagtacc gcatgatcct gtcagtaaat attgcagatt ttcaagagaa 1620 tcagtgggtg acttgtttcc aggagtctgc tgaagctatc cttggacaaa atgctgctta 1680 tcttggggaa ttaaaagaca agaatgaaca ggcatttgaa gaagttttcc agaatgccaa 1740 cttccgatct ttcatattca gagtcagggt caaagtggag acctacaacg acgagtctcg 1800 aattaaggcc actgtgatgg acgtgaagcc cgtggactac agagagtatg gccgaaggct 1860 ggtcatgagc atcaggagaa gtgcattgat gtgagaggag cagtgccaat cgggcagaag 1920 tttgcaaata ggcagaatgg aatcgatttc ctcccacctc cgtgtgacga tcccatgtta 1980 gctacacagt gcagaggctc ttgatggtgg actaagcaat ttcctccctt gtgcgcatct 2040 cagaacccat cggtaggcaa aggaaaatac gctcaggtgg ttgtggtgta gactgtgtca 2100 ggcctacgga gtcagccagt ggctagcgca agaccagtca ctccctctgc cttcaggctt 2160 ctgtcaattt cattatcatc aagcaggaat tatgtcgtaa gtcactgacc ctaactgcag 2220 accatgaagt aaattatgta actaggtttt tgcttctcca gtggtgacca cccccccccc 2280 atccccgctc acaacttggg ttcttctcag cggggcgagc tgagaagcgg tcatgagcac 2340 ctggggattt tagtaagtgt gtcttcctag aattcgaagg ctctctcttt ctagaggtgc 2400 tacatagttg gtaatgcttg gaatggcaat agggtagaat gattaatcaa aggcatatct 2460 tctatatctg aagagtatcc ttccttcagg gtttaataga ctgagtcaga tgggtctgat 2520 attaatcaaa attgtctctt ctgaggaccg ctgataagca ttgacttgct gtcccctaag 2580 gaaatccgag cggctacaaa gcgtttcttt acttttcact tcaattaatg ctgcgcttcg 2640 cttggtgagt gcgtactttt tctacctgta cacattcctg cattcatgta ttttgttttt 2700 tttgactaaa gctatgttac atggaaagga ttttgaagcc ttttgtttcc cttgctttgt 2760 tttaataaac agtatattct ttggttgtga atcctaaaaa aaaaaaaaaa aaaaaaaaaa 2820 aaaa 2824 <210> 141 <211> 2393 <212> DNA <213> Homo sapiens <400> 141 cggcgcggga cccgggtggg gaagctggag ctgttgcggg gtccgcgggg aagtcttggc 60 ggtggagcca tggtcggcca gctgagcgag ggggccattg cggccatcat gcagaagggg 120 gatacaaaca taaagcccat cctccaagtc atcaacatcc gtcccattac tacggggaat 180 agtccgccgc gttatcgact gctcatgagt gatggattga acactctatc ctctttcatg 240 ttggcgacac agttgaaccc tctcgtggag gaagaacaat tgtccagcaa ctgtgtatgc 300 cagattcaca gatttattgt gaacactctg aaagacggaa ggagagtagt tatcttgatg 360 gaattagaag ttttgaagtc agctgaagca gttggagtga agattggcaa tccagtgccc 420 tataatgaag gactcgggca gccgcaagta gctcctccag cgccagcagc cagcccagca 480 gcaagcagca ggccccagcc gcagaatgga agctcgggaa tgggttctac tgtttctaag 540 gcttatggtg cttcaaagac atttggaaaa gctgcaggtc ccagcctgtc acacacttct 600 gggggaacac agtccaaagt ggtgcccatt gccagcctca ctccttacca gtccaagtgg 660 accatttgtg ctcgtgttac caacaaaagt cagatccgta cctggagcaa ctcccgaggg 720 gaagggaagc ttttctccct agaactggtt gacgaaagtg gtgaaatccg agctacagct 780 ttcaatgagc aagtggacaa gttctttcct cttattgaag tgaacaaggt gtattatttc 840 tcgaaaggca ccctgaagat tgctaacaag cagttcacag ctgttaaaaa tgactacgag 900 atgaccttca ataacgagac ttccgtcatg ccctgtgagg acgaccatca tttacctacg 960 gttcagtttg atttcacggg gattgatgac ctcgagaaca agtcgaaaga ctcacttgta 1020 gacatcatcg ggatctgcaa gagctatgaa gacgccacta aaatcacagt gaggtctaac 1080 aacagagaag ttgccaagag gaatatctac ttgatggaca catccgggaa ggtggtgact 1140 gctacactgt ggggggaaga tgctgataaa tttgatggtt ctagacagcc cgtgttggct 1200 atcaaaggag cccgagtctc tgatttcggt ggacggagcc tctccgtgct gtcttcaagc 1260 actatcattg cgaatcctga catcccagag gcctataagc ttcgtggatg gtttgacgca 1320 gaaggacaag ccttagatgg tgtttccatc tctgatctaa agagcggcgg agtcggaggg 1380 agtaacacca actggaaaac cttgtatgag gtcaaatccg agaacctggg ccaaggcgac 1440 aagccggact actttagttc tgtggccaca gtggtgtatc ttcgcaaaga gaactgcatg 1500 taccaagcct gcccgactca ggactgcaat aagaaagtga ttgatcaaca gaatggattg 1560 taccgctgtg agaagtgcga caccgaattt cccaatttca agtaccgcat gatcctgtca 1620 gtaaatattg cagattttca agagaatcag tgggtgactt gtttccagga gtctgctgaa 1680 gctatccttg gacaaaatgc tgcttatctt ggggaattaa aagacaagaa tgaacaggca 1740 tttgaagaag ttttccagaa tgccaacttc cgatctttca tattcagagt cagggtcaaa 1800 gtggagacct acaacgacga gtctcgaatt aaggccactg tgatggacgt gaagcccgtg 1860 gactacagag agtatggccg aaggctggtc atgagcatca ggagaagtgc attgatgtga 1920 gaggagcagt gccaatcggg cagaagtttg caaataggca gaatggaatc gatttcctcc 1980 cacctccgtg tgacgatccc atgttagcta cacagtgcag aggctcttga tggtggacta 2040 agcaattcct ccctcgtgcg catctcagaa cccatcggta ggcaaaggaa aatacgctca 2100 ggtggttgtg gtgtagactg tgtcaggcct acggagtcag ccagtggcta gcgcaagacc 2160 agtcactccc tctgccttca ggcttctgtc aatttcatta tcatcaagca ggaattatgt 2220 cgtaagtcac tgaccctaac tgcagaccat gaagtaaatt atgtaactag gtttttgctt 2280 ctccagtggt gaccaccccc ccccatcccc gctcacaact tgggttcttc tcagcggggc 2340 gagctgagaa gcggtcatga gcacctgggg attttagtaa gtgtgtcttc cta 2393 <210> 142 <211> 1741 <212> DNA <213> Homo sapiens <400> 142 cttcgtaaag atggccgcgg aggcttttgg agccaactgg gagcgcagta cgcgttttct 60 ggagcatggg cagaggagac aggaacaagc gtagcatccg tgagcaccga ttggctgaag 120 cgagcacccc gggagctgac tggctccgcc attcgcggga aggcgtttgt ggtgccagag 180 aaaagtagcc agagcggcgc agtggcggcc gcgttctgtg gttttccgct attcccccag 240 acccgcacct tctcggcctc tttgcggaga atcgtgacca agatgtggaa cagtggattc 300 gaaagctatg gcagctcctc atacggggga gccggcggct acacgcagtc cccggggggc 360 tttggatcgc ccgcaccttc tcaagccgaa aagaaatcaa gagcccgagc ccagcacatt 420 gtgccctgta ctatatctca gctgctttct gccactttgg ttgatgaagt gttcagaatt 480 gggaatgttg agatttcaca ggtcactatt gtggggatca tcagacatgc agagaaggct 540 ccaaccaaca ttgtttacaa aatagatgac atgacagctg cacccatgga cgttcgccag 600 tgggttgaca cagatgacac cagcagtgaa aacactgtgg ttcctccaga aacatatgtg 660 aaagtggcag gccacctgag atcttttcag aacaaaaaga gcctggtagc ctttaagatc 720 atgcccctgg aggatatgaa tgagttcacc acacatattc tggaagtgat caatgcacac 780 atggtactaa gcaaagccaa cagccagccc tcagcaggga gagcacctat cagcaatcca 840 ggaatgagtg aagcagggaa ctttggtggg aatagcttca tgccagcaaa tggcctcact 900 gtggcccaaa accaggtgtt gaatttgatt aaggcttgtc caagacctga agggttgaac 960 tttcaggatc tcaagaacca gctgaaacac atgtctgtat cctcaatcaa gcaagctgtg 1020 gattttctga gcaatgaggg gcacatctat tctactgtgg atgatgacca ttttaaatcc 1080 acagatgcag aataactgga tctaactggg tacctgagat attttacagc tggacctagt 1140 ttcacaatct gttgtctcca gctctgcata tgtctggcca gggggcttct aggaagtagg 1200 tttcatctat caaatgtctc ctctgacttc cttttgaaac ttactgctct tctgttttat 1260 tttgttttgt ttgaagctca gagggagatg ggcaattgac agggatgcaa tccagggtgg 1320 gatttcttga ggaagttaca aataagcttg ttacaacatc aagatagatg gaattggaag 1380 gatgctacca ggagagtact tacatagtgc tcaggagttt ctcttcttaa aatgtttact 1440 gctgaaagat gagcaggacc agggcgttat aggcagagcc ctagccgaga aacctgctgg 1500 cctctgcctg ttttcatttc ccactttggt tgtgtggcat tactttcaga attgcacttt 1560 cctgcttgtc atgacttttt gacacacttg ccatgacgtg tgtttctgtg aacatgaagt 1620 tctgcggtag tgcctccagg ggcagaggaa aagaagaagt gttactgcgt tttgtacaaa 1680 ataaatacag tcatatgttt aataaaacag ttctattgta aaaaaaaaaa aaaaaaaaaa 1740 a 1741 <210> 143 <211> 1741 <212> DNA <213> Homo sapiens <400> 143 cttcgtaaag atggccgcgg aggcttttgg agccaactgg gagcgcagta cgcgttttct 60 ggagcatggg cagaggagac aggaacaagc gtagcatccg tgagcaccga ttggctgaag 120 cgagcacccc gggagctgac tggctccgcc attcgcggga aggcgtttgt ggtgccagag 180 aaaagtagcc agagcggcgc agtggcggcc gcgttctgtg gttttccgct attcccccag 240 acccgcacct tctcggcctc tttgcggaga atcgtgacca agatgtggaa cagtggattc 300 gaaagctatg gcagctcctc atacggggga gccggcggct acacgcagtc cccggggggc 360 tttggatcgc ccgcaccttc tcaagccgaa aagaaatcaa gagcccgagc ccagcacatt 420 gtgccctgta ctatatctca gctgctttct gccactttgg ttgatgaagt gttcagaatt 480 gggaatgttg agatttcaca ggtcactatt gtggggatca tcagacatgc agagaaggct 540 ccaaccaaca ttgtttacaa aatagatgac atgacagctg cacccatgga cgttcgccag 600 tgggttgaca cagatgacac cagcagtgaa aacactgtgg ttcctccaga aacatatgtg 660 aaagtggcag gccacctgag atcttttcag aacaaaaaga gcctggtagc ctttaagatc 720 atgcccctgg aggatatgaa tgagttcacc acacatattc tggaagtgat caatgcacac 780 atggtactaa gcaaagccaa cagccagccc tcagcaggga gagcacctat cagcaatcca 840 ggaatgagtg aagcagggaa ctttggtggg aatagcttca tgccagcaaa tggcctcact 900 gtggcccaaa accaggtgtt gaatttgatt aaggcttgtc caagacctga agggttgaac 960 tttcaggatc tcaagaacca gctgaaacac atgtctgtat cctcaatcaa gcaagctgtg 1020 gattttctga gcaatgaggg gcacatctat tctactgtgg atgatgacca ttttaaatcc 1080 acagatgcag aataactgga tctaactggg tacctgagat attttacagc tggacctagt 1140 ttcacaatct gttgtctcca gctctgcata tgtctggcca gggggcttct aggaagtagg 1200 tttcatctat caaatgtctc ctctgacttc cttttgaaac ttactgctct tctgttttat 1260 tttgttttgt ttgaagctca gagggagatg ggcaattgac agggatgcaa tccagggtgg 1320 gatttcttga ggaagttaca aataagcttg ttacaacatc aagatagatg gaattggaag 1380 gatgctacca ggagagtact tacatagtgc tcaggagttt ctcttcttaa aatgtttact 1440 gctgaaagat gagcaggacc agggcgttat aggcagagcc ctagccgaga aacctgctgg 1500 cctctgcctg ttttcatttc ccactttggt tgtgtggcat tactttcaga attgcacttt 1560 cctgcttgtc atgacttttt gacacacttg ccatgacgtg tgtttctgtg aacatgaagt 1620 tctgcggtag tgcctccagg ggcagaggaa aagaagaagt gttactgcgt tttgtacaaa 1680 ataaatacag tcatatgttt aataaaacag ttctattgta aaaaaaaaaa aaaaaaaaaa 1740 a 1741 <210> 144 <211> 1602 <212> DNA <213> Homo sapiens <400> 144 ctggctccgc cattcgcggg aaggcgtttg tggtgccaga gaaaagtagc cagagcggcg 60 cagtggcggc cgcgttctgt ggttttccgc tattccccca gacccgcacc ttctcggcct 120 ctttgcggag aatcgtgacc aagatgtgga acagtggatt cgaaagctat ggcagctcct 180 catacggggg agccggcggc tacacgcagt ccccgggggg ctttggatcg cccgcacctt 240 ctcaagccga aaagaaatca agagcccgag cccagcacat tgtgccctgt actatatctc 300 agctgctttc tgccactttg gttgatgaag tgttcagaat tgggaatgtt gagatttcac 360 aggtcactat tgtggggatc atcagacatg cagagaaggc tccaaccaac attgtttaca 420 aaatagatga catgacagct gcacccatgg acgttcgcca gtgggttgac acagatgaca 480 ccagcagtga aaacactgtg gttcctccag aaacatatgt gaaagtggca ggccacctga 540 gatcttttca gaacaaaaag agcctggtag cctttaagat catgcccctg gaggatatga 600 atgagttcac cacacatatt ctggaagtga tcaatgcaca catggtacta agcaaagcca 660 acagccagcc ctcagcaggg agagcaccta tcagcaatcc aggaatgagt gaagcaggga 720 actttggtgg gaatagcttc atgccagcaa atggcctcac tgtggcccaa aaccaggtgt 780 tgaatttgat taaggcttgt ccaagacctg aagggttgaa ctttcaggat ctcaagaacc 840 agctgaaaca catgtctgta tcctcaatca agcaagctgt ggattttctg agcaatgagg 900 ggcacatcta ttctactgtg gatgatgacc attttaaatc cacagatgca gaataactgg 960 atctaactgg gtacctgaga tattttacag ctggacctag tttcacaatc tgttgtctcc 1020 agctctgcat atgtctggcc agggggcttc taggaagtag gtttcatcta tcaaatgtct 1080 cctctgactt ccttttgaaa cttactgctc ttctgtttta ttttgttttg tttgaagctc 1140 agagggagat gggcaattga cagggatgca atccagggtg ggatttcttg aggaagttac 1200 aaataagctt gttacaacat caagatagat ggaattggaa ggatgctacc aggagagtac 1260 ttacatagtg ctcaggagtt tctcttctta aaatgtttac tgctgaaaga tgagcaggac 1320 cagggcgtta taggcagagc cctagccgag aaacctgctg gcctctgcct gttttcattt 1380 cccactttgg ttgtgtggca ttactttcag aattgcactt tcctgcttgt catgactttt 1440 tgacacactt gccatgacgt gtgtttctgt gaacatgaag ttctgcggta gtgcctccag 1500 gggcagagga aaagaagaag tgttactgcg ttttgtacaa aataaataca gtcatatgtt 1560 taataaaaca gttctattgt aaaaaaaaaa aaaaaaaaaa aa 1602 <210> 145 <211> 1546 <212> DNA <213> Homo sapiens <400> 145 gagcggcgca gtggcggccg cgttctgtgg ttttccgcta ttcccccaga cccgcacctt 60 ctcggcctct ttgcggagaa tcgtgaccaa gatgtggaac agtggattcg aaagctatgg 120 cagctcctca tacgggggag ccggcggcta cacgcagtcc ccggggggct ttggatcgcc 180 cgcaccttct caagccgaaa agaaatcaag agcccgagcc cagcacattg tgccctgtac 240 tatatctcag ctgctttctg ccactttggt tgatgaagtg ttcagaattg ggaatgttga 300 gatttcacag gtcactattg tggggatcat cagacatgca gagaaggctc caaccaacat 360 tgtttacaaa atagatgaca tgacagctgc acccatggac gttcgccagt gggttgacac 420 agatgacacc agcagtgaaa acactgtggt tcctccagaa acatatgtga aagtggcagg 480 ccacctgaga tcttttcaga acaaaaagag cctggtagcc tttaagatca tgcccctgga 540 ggatatgaat gagttcacca cacatattct ggaagtgatc aatgcacaca tggtactaag 600 caaagccaac agccagccct cagcagggag agcacctatc agcaatccag gaatgagtga 660 agcagggaac tttggtggga atagcttcat gccagcaaat ggcctcactg tggcccaaaa 720 ccaggtgttg aatttgatta aggcttgtcc aagacctgaa gggttgaact ttcaggatct 780 caagaaccag ctgaaacaca tgtctgtatc ctcaatcaag caagctgtgg attttctgag 840 caatgagggg cacatctatt ctactgtgga tgatgaccat tttaaatcca cagatgcaga 900 ataactggat ctaactgggt acctgagata ttttacagct ggacctagtt tcacaatctg 960 ttgtctccag ctctgcatat gtctggccag ggggcttcta ggaagtaggt ttcatctatc 1020 aaatgtctcc tctgacttcc ttttgaaact tactgctctt ctgttttatt ttgttttgtt 1080 tgaagctcag agggagatgg gcaattgaca gggatgcaat ccagggtggg atttcttgag 1140 gaagttacaa ataagcttgt tacaacatca agatagatgg aattggaagg atgctaccag 1200 gagagtactt acatagtgct caggagtttc tcttcttaaa atgtttactg ctgaaagatg 1260 agcaggacca gggcgttata ggcagagccc tagccgagaa acctgctggc ctctgcctgt 1320 tttcatttcc cactttggtt gtgtggcatt actttcagaa ttgcactttc ctgcttgtca 1380 tgactttttg acacacttgc catgacgtgt gtttctgtga acatgaagtt ctgcggtagt 1440 gcctccaggg gcagaggaaa agaagaagtg ttactgcatt ttgtacaaaa taaatacagt 1500 catatgttta ataaaacagt tctattgtaa aaaaaaaaaa aaaaaa 1546 <210> 146 <211> 1512 <212> DNA <213> Homo sapiens <400> 146 cggccgcgtt ctgtggtttt ccgctattcc cccagacccg caccttctcg gcctctttgc 60 ggagaatcgt gaccaagatg tggaacagtg gattcgaaag ctatggcagc tcctcatacg 120 ggggagccgg cggctacacg cagtccccgg ggggctttgg atcgcccgca ccttctcaag 180 ccgaaaagaa atcaagagcc cgagcccagc acattgtgcc ctgtactata tctcagctgc 240 tttctgccac tttggttgat gaagtgttca gaattgggaa tgttgagatt tcacaggtca 300 ctattgtggg gatcatcaga catgcagaga aggctccaac caacattgtt tacaaaatag 360 atgacatgac agctgcaccc atggacgttc gccagtgggt tgacacagat gacaccagca 420 gtgaaaacac tgtggttcct ccagaaacat atgtgaaagt ggcaggccac ctgagatctt 480 ttcagaacaa aaagagcctg gtagccttta agatcatgcc cctggaggat atgaatgagt 540 tcaccacaca tattctggaa gtgatcaatg cacacatggt actaagcaaa gccaacagcc 600 agccctcagc agggagagca cctatcagca atccaggaat gagtgaagca gggaactttg 660 gtgggaatag cttcatgcca gcaaatggcc tcactgtggc ccaaaaccag gtgttgaatt 720 tgattaaggc ttgtccaaga cctgaagggt tgaactttca ggatctcaag aaccagctga 780 aacacatgtc tgtatcctca atcaagcaag ctgtggattt tctgagcaat gaggggcaca 840 tctattctac tgtggatgat gaccatttta aatccacaga tgcagaataa ctggatctaa 900 ctgggtacct gagatatttt acagctggac ctagtttcac aatctgttgt ctccagctct 960 gcatatgtct ggccaggggg cttctaggaa gtaggtttca tctatcaaat gtctcctctg 1020 acttcctttt gaaacttact gctcttctgt tttattttgt tttgtttgaa gctcagaggg 1080 agatgggcaa ttgacaggga tgcaatccag ggtgggattt cttgaggaag ttacaaataa 1140 gcttgttaca acatcaagat agatggaatt ggaaggatgc taccaggaga gtacttacat 1200 agtgctcagg agtttctctt cttaaaatgt ttactgctga aagatgagca ggaccagggc 1260 gttataggca gagccctagc cagaaacctg ctggcctctg cctgttttca tttcccactt 1320 tggttgtgtg gcattacttt cagaattgca ctttcctgct tgtcatgact ttttgacaca 1380 cttgccatga cgtgtgtttc tgtgaacatg aagttctgcg gtagtgcctc caggggcaga 1440 ggaaaagaag aagtgttact gcattttgta caaaataaat acagtcatat gtttaataaa 1500 acagttctac cg 1512 <210> 147 <211> 1355 <212> DNA <213> Homo sapiens <400> 147 ggatggccgg agctggcgcc ctggttctgg aggtaaccgg ttactgaggg cgagaagcgc 60 cacccggagg ctctagcctg acaaatgctt gctgacctgg gccagagctc ttcccttacg 120 caagtctcag ccggtcgtcg cgacgttcgc ccgctcgctc tgaggctcct gaagccgaaa 180 ccagctagac tttcctcctt cccgcctgcc tgtagcggcg ttgttgccac tccgccacca 240 tgttcgaggc gcgcctggtc cagggctcca tcctcaagaa ggtgttggag gcactcaagg 300 acctcatcaa cgaggcctgc tgggatatta gctccagcgg tgtaaacctg cagagcatgg 360 actcgtccca cgtctctttg gtgcagctca ccctgcggtc tgagggcttc gacacctacc 420 gctgcgaccg caacctggcc atgggcgtga acctcaccag tatgtccaaa atactaaaat 480 gcgccggcaa tgaagatatc attacactaa gggccgaaga taacgcggat accttggcgc 540 tagtatttga agcaccaaac caggagaaag tttcagacta tgaaatgaag ttgatggatt 600 tagatgttga acaacttgga attccagaac aggagtacag ctgtgtagta aagatgcctt 660 ctggtgaatt tgcacgtata tgccgagatc tcagccatat tggagatgct gttgtaattt 720 cctgtgcaaa agacggagtg aaattttctg caagtggaga acttggaaat ggaaacatta 780 aattgtcaca gacaagtaat gtcgataaag aggaggaagc tgttaccata gagatgaatg 840 aaccagttca actaactttt gcactgaggt acctgaactt ctttacaaaa gccactccac 900 tctcttcaac ggtgacactc agtatgtctg cagatgtacc ccttgttgta gagtataaaa 960 ttgcggatat gggacactta aaatactact tggctcccaa gatcgaggat gaagaaggat 1020 cttaggcatt cttaaaattc aagaaaataa aactaagctc tttgagaact gcttctaaga 1080 tgccagcata tactgaagtc ttttctgtca ccaaatttgt acctctaagt acatatgtag 1140 atattgtttt ctgtaaataa cctatttttt tctctattct ctgcaatttg tttaaagaat 1200 aaagtccaaa gtcagatctg gtctagttaa cctagaagta tttttgtctc ttagaaatac 1260 ttgtgatttt tataatacaa aagggtcttg actctaaatg cagttttaag aattgttttt 1320 gaatttaaat aaagttactt gaatttcaaa catca 1355 <210> 148 <211> 1319 <212> DNA <213> Homo sapiens <400> 148 aacgcggcgc agggtgagag cgcgcgcttg cggacgcggc ggcattaaac ggttgcaggc 60 gtagcagagt ggtcgttgtc tttctaggtc tcagccggtc gtcgcgacgt tcgcccgctc 120 gctctgaggc tcctgaagcc gaaaccagct agactttcct ccttcccgcc tgcctgtagc 180 ggcgttgttg ccactccgcc accatgttcg aggcgcgcct ggtccagggc tccatcctca 240 agaaggtgtt ggaggcactc aaggacctca tcaacgaggc ctgctgggat attagctcca 300 gcggtgtaaa cctgcagagc atggactcgt cccacgtctc tttggtgcag ctcaccctgc 360 ggtctgaggg cttcgacacc taccgctgcg accgcaacct ggccatgggc gtgaacctca 420 ccagtatgtc caaaatacta aaatgcgccg gcaatgaaga tatcattaca ctaagggccg 480 aagataacgc ggataccttg gcgctagtat ttgaagcacc aaaccaggag aaagtttcag 540 actatgaaat gaagttgatg gatttagatg ttgaacaact tggaattcca gaacaggagt 600 acagctgtgt agtaaagatg ccttctggtg aatttgcacg tatatgccga gatctcagcc 660 atattggaga tgctgttgta atttcctgtg caaaagacgg agtgaaattt tctgcaagtg 720 gagaacttgg aaatggaaac attaaattgt cacagacaag taatgtcgat aaagaggagg 780 aagctgttac catagagatg aatgaaccag ttcaactaac ttttgcactg aggtacctga 840 acttctttac aaaagccact ccactctctt caacggtgac actcagtatg tctgcagatg 900 taccccttgt tgtagagtat aaaattgcgg atatgggaca cttaaaatac tacttggctc 960 ccaagatcga ggatgaagaa ggatcttagg cattcttaaa attcaagaaa ataaaactaa 1020 gctctttgag aactgcttct aagatgccag catatactga agtcttttct gtcaccaaat 1080 ttgtacctct aagtacatat gtagatattg ttttctgtaa ataacctatt tttttctcta 1140 ttctctgcaa tttgtttaaa gaataaagtc caaagtcaga tctggtctag ttaacctaga 1200 agtatttttg tctcttagaa atacttgtga tttttataat acaaaagggt cttgactcta 1260 aatgcagttt taagaattgt ttttgaattt aaataaagtt acttgaattt caaacatca 1319 <210> 149 <211> 1271 <212> DNA <213> Homo sapiens <400> 149 gcgtagcaga gtggtcgttg tctttctagg tctcagccgg tcgtcgcgac gttcgcccgc 60 tcgctctgag gctcctgaag ccgaaaccag ctagactttc ctccttcccg cctgcctgta 120 gcggcgttgt tgccactccg ccaccatgtt cgaggcgcgc ctggtccagg gctccatcct 180 caagaaggtg ttggaggcac tcaaggacct catcaacgag gcctgctggg atattagctc 240 cagcggtgta aacctgcaga gcatggactc gtcccacgtc tctttggtgc agctcaccct 300 gcggtctgag ggcttcgaca cctaccgctg cgaccgcaac ctggccatgg gcgtgaacct 360 caccagtatg tccaaaatac taaaatgcgc cggcaatgaa gatatcatta cactaagggc 420 cgaagataac gcggatacct tggcgctagt atttgaagca ccaaaccagg agaaagtttc 480 agactatgaa atgaagttga tggatttaga tgttgaacaa cttggaattc cagaacagga 540 gtacagctgt gtagtaaaga tgccttctgg tgaatttgca cgtatatgcc gagatctcag 600 ccatattgga gatgctgttg taatttcctg tgcaaaagac ggagtgaaat tttctgcaag 660 tggagaactt ggaaatggaa acattaaatt gtcacagaca agtaatgtcg ataaagagga 720 ggaagctgtt accatagaga tgaatgaacc agttcaacta acttttgcac tgaggtacct 780 gaacttcttt acaaaagcca ctccactctc ttcaacggtg acactcagta tgtctgcaga 840 tgtacccctt gttgtagagt ataaaattgc ggatatggga cacttaaaat actacttggc 900 tcccaagatc gaggatgaag aaggatctta ggcattctta aaattcaaga aaataaaact 960 aagctctttg agaactgctt ctaagatgcc agcatatact gaagtctttt ctgtcaccaa 1020 atttgtacct ctaagtacat atgtagatat tgttttctgt aaataaccta tttttttctc 1080 tattctctgc aatttgttta aagaataaag tccaaagtca gatctggtct agttaaccta 1140 gaagtatttt tgtctcttag aaatacttgt gatttttata atacaaaagg gtcttgactc 1200 taaatgcagt tttaagaatt gtttttgaat ttaaataaag ttacttgaat ttcaaaaaaa 1260 aaaaaaaaaa a 1271 <210> 150 <211> 1231 <212> DNA <213> Homo sapiens <400> 150 aggtctcagc cggtcgtcgc gacgttcgcc cgctcgctct gaggctcctg aagccgaaac 60 tagctagact ttcctccttc ccgcctgcct gtagcggcgt tgttgccact ccgccaccat 120 gttcgaggcg cgcctggtcc agggctccat cctcaagaag gtgttggagg cactcaagga 180 cctcatcaac gaggcctgct gggatattag ctccagcggt gtaaacctgc agagcatgga 240 ctcgtcccac gtctctttgg tgcagctcac cctgcggtct gagggcttcg acacctaccg 300 ctgcgaccgc aacctggcca tgggcgtgaa cctcaccagt atgtccaaaa tactaaaatg 360 cgccggcaat gaagatatca ttacactaag ggccgaagat aacgcggata ccttggcgct 420 agtatttgaa gcaccaaacc aggagaaagt ttcagactat gaaatgaagt tgatggattt 480 agatgttgaa caacttggaa ttccagaaca ggagtacagc tgtgtagtaa agatgccttc 540 tggtgaattt gcacgtatat gccgagatct cagccatatt ggagatgctg ttgtaatttc 600 ctgtgcaaaa gacggagtga aattttctgc aagtggagaa cttggaaatg gaaacattaa 660 attgtcacag acaagtaatg tcgataaaga ggaggaagct gttaccatag agatgaatga 720 accagttcaa ctaacttttg cactgaggta cctgaacttc tttacaaaag ccactccact 780 ctcttcaacg gtgacactca gtatgtctgc agatgtaccc cttgttgtag agtataaaat 840 tgcggatatg ggacacttaa aatactactt ggctcccaag atcgaggatg aagaaggatc 900 ttaggcattc ttaaaattca agaaaataaa actaagctct ttgagaactg cttctaagat 960 gccagcatat actgaagtct tttctgtcac caaatttgta cctctaagta catatgtaga 1020 tattgttttc tgtaaataac ctattttttt tctctattct ctccaatttg tttaaagaat 1080 aaagtccaaa gtctgatctg gtctagttaa cctagaagta tttttgtctc ttagaaatac 1140 ttgtgatttt tataatacaa aagggtcttg actctaaatg cagttttaag aagtgttttt 1200 gaatttaaat aaagttactt gaatttcaaa c 1231 <210> 151 <211> 6245 <212> DNA <213> Homo sapiens <400> 151 tttcctccga agctctgtgg tccgatctgc ggtccgcttg ctttccctgc ccggtcccga 60 gcgctcagcc tgaagcgccg ctttcgaggg caccctgcat acactggccg cgcctcaggg 120 atctcattgc ccgcgctttc tcattgcctc tttccgtgtt cgattcggct gatctgggcc 180 cagcctccgc tcccgctctc tgtcggtggg cgcgggggaa tccgaaacgg ctcagcagaa 240 tcccagcagc ttgctgctac tggagcgggc cgcctccatg gcctccaggc aggccgggct 300 ggaccgcgtg aggtcctagg agacgggatt ccgggaagcg gggagtatgg tgggggtcct 360 ggccatggcg gctgcagctg ctccgcctcc cgtgaaggac tgcgagattg agccatgcaa 420 aaagcgaaag aaagatgatg acacatctac ctgcaaaaca attacaaaat atttatcacc 480 actagggaag actagagaca gggtttttgc tccaccaaaa cctagtaata ttctggatta 540 ttttagaaag acttcaccca caaatgagaa gacacaatta gggaaagagt gcaagataaa 600 gtcacctgaa tcagtacctg ttgacagcaa caaagactgt acgacacctt tggaaatgtt 660 ctcaaatgta gagtttaaga agaaaagaaa gagggttaat ttatctcatc aactaaataa 720 tattaaaact gaaaatgaag ctccaattga aattagtagc gacgatagca aagaagacta 780 tagtttaaat aatgattttg tggaaagtag tacttctgtt ttacgttaca agaaacaagt 840 agaggtactt gcagaaaaca ttcaagatac aaaaagtcaa ccaaatacta tgacctccct 900 gcaaaattct aaaaaagtaa atcctaaaca agggaccaca aaaaatgact tcaaaaagtt 960 gagaaaaagg aaatgcagag atgtagtaga tctatctgaa agcttaccct tggcagagga 1020 actaaatttg cttaaaaaag atggtaaaga tactaaacag atggagaata ctacaagcca 1080 tgcaaactct agagataacg taactgaagc agcccagtta aatgatagta taataactgt 1140 ctcatatgag gaatttttaa aaagtcacaa ggaaaataaa gtggaagaga taccagactc 1200 tacaatgtca atttgtgttc cttctgaaac tgtcgacgaa atagtcaaaa gtggttatat 1260 aagtgaatca gaaaactccg aaatttccca gcaggtacgc tttaagacag ttactgttct 1320 tgcacaggtt caccctattc cgcccaaaaa gacagggaaa ataccccgaa ttttcttgaa 1380 acaaaagcaa tttgaaatgg aaaatagttt atctgatcct gagaatgaac agacagttca 1440 gaaaagaaaa tctaatgttg ttatacagga ggaagaatta gaattggctg ttttggaagc 1500 tggaagttct gaagctgtga aaccaaaatg cactctagaa gaaagacagc aatttatgaa 1560 agcatttagg cagccagcat cagatgcact taaaaatgga gttaaaaagt cttctgataa 1620 gcagaaagac cttaatgaaa aatgtctata tgaagtagga agagatgata attctaaaaa 1680 aatcatggaa aattctggta tccaaatggt ttcaaaaaat ggcaatttac agttacacac 1740 tgataaagga agttttctga aggagaaaaa taaaaagcta aagaagaaga ataagaaaac 1800 attagatact ggggctattc caggcaaaaa cagagaggga aacactcaaa agaaagaaac 1860 aacctttttc ttaaaagaga aacaatatca aaatagaatg agtttaagac aaaggaaaac 1920 agagtttttc aaaagcagca ctttatttaa caatgaaagt cttgtttatg aagatatagc 1980 aaatgatgac cttctaaagg tttcctctct gtgtaacaat aataaattgt caagaaaaac 2040 cagcatacca gttaaagata ttaagcttac acagtctaaa gctgaatctg aagccagctt 2100 gctaaatgtt tccacgccca agtcaactag aagatctgga agaattagca gcacacctac 2160 tacagaaacc attagaggta ttgattctga cgatgtacaa gataatagtc aactaaaggc 2220 ttccactcaa aaagcagcca acttatcgga aaagcacagc ttatatacag cagaattaat 2280 aacagtaccc tttgattcag agagccctat tagaatgaaa ttcaccagaa ttagtactcc 2340 caaaaaatct aagaaaaaat ctaacaaaag atctgagaaa tctgaagcaa ctgatggagg 2400 ttttacttct cagattagaa aggcaagcaa tacttcaaaa aacatatcaa aagcaaaaca 2460 attgattgaa aaagcaaaag ctttacacat cagtaggtca aaggtgactg aagaaatagc 2520 gataccctta aggcgctcct ctagacatca gacacttcct gaaaggaaga aattgtcaga 2580 aacagaagat tctgttataa taatagattc aagtcctact gctttaaagc atccagagaa 2640 aaatcagaag aaacttcagt gtttgaatga tgtgctagga aaaaaactta acacatccac 2700 taaaaatgta cctggaaaaa tgaaagtcgc tcctttattt cttgtcagaa aagcacaaaa 2760 agcagctgat cctgtcccta gttttgatga aagcagtcaa gatacatctg aaaaatctca 2820 ggattgtgat gttcaatgta aagcaaagcg tgacttccta atgagtggtt tgccagattt 2880 gttgaaacgg caaattgcaa agaaagctgc tgcgctggat gtgtacaatg cagtgagtac 2940 cagtttccag agagtcgtac atgtgcaaca aaaggatgat gggtgttgtt tgtggcattt 3000 gaaaccaccc tcttgtcctc tcttaactaa atttaaagaa ctgaacacta aagtaataga 3060 tctctcaaaa tgtggtattg ctcttggtga attttcaaca ttgaattcaa agttgaaaag 3120 cggtaactct gctgctgtgt tcatgaggac aaggaaggaa tttactgaag aagtaagaaa 3180 tcttttgctt gaggaaatta ggtggtcaaa tcctgaattt tcattgaaaa aatattttcc 3240 cttactccta aaaaaacaaa ttgagcacca agtactttct tccgagtgtc atagtaaaca 3300 agaactggag gctgatgtca gccataaaga aaccaaaagg aaactcgtag aagcagaaaa 3360 ttctaagtca aaaagaaaga aaccaaatga gtattcaaaa aatctggaga agaccaatag 3420 gaagtcagaa gaacttagca aaagaaacaa ctcttctggg ataaagctag attcttccaa 3480 agattctgga actgaagaca tgctttggac agaaaagtat caacctcaga ctgccagtga 3540 acttatagga aatgagttag ctataaaaaa gttacatagt tggttgaaag actggaaaag 3600 aagagctgaa ttggaagaaa ggcagaatct gaagggaaaa agagatgaga aacatgaaga 3660 tttctcgggt ggcatagact ttaaaggcag ttcagatgat gaagaagaga gtcgtctttg 3720 caatactgtc cttataacag ggccaacagg agtgggaaaa actgctgcag tgtatgcttg 3780 tgcccaggag cttggattta agatatttga agtgaatgcc tcttcccagc gcagtggtag 3840 acaaattcta tctcagttga aggaagctac tcagtcccat caagtagaca aacaaggtgt 3900 aaactcacaa aaaccctgtt tttttaatag ctactacata ggcaagtcac caaaaaaaat 3960 aagctcccct aagaaagttg ttacatcacc aagaaaagtt cctccaccat caccaaaaag 4020 tagtggacca aagcgagcac ttcctcccaa aaccttggca aattatttta aagtatctcc 4080 caaacctaaa aataatgaag aaataggaat gcttctggaa aataataaag gaataaaaaa 4140 ttcttttgaa cagaaacaaa ttactcagac taaatctaca aatgcaacta attcaaatgt 4200 caaagacgtt ggagctgaag aacccagcag aaaaaatgca acatctctta ttctttttga 4260 ggaggttgat gtaatttttg atgaagatgc tgggtttttg aatgcaatca aaacattcat 4320 ggcaacaact aaacgacctg taatccttac tacaagtgac ccaacattta gtttaatgtt 4380 tgatggctgc tttgaagaaa tcaagttcag tactccttcc ctgctaaatg ttgccagcta 4440 cctacaaatg atttgcttaa ctgagaattt tagaactgat gtaaaagact ttgtaacctt 4500 gttaactgca aatacttgtg atatcagaaa aagtatcctt tacttacaat tctggattag 4560 aagtggaggt ggagttttag aagaacgacc attaaccctt tatcgtggaa atagcagaaa 4620 tgtacaacta gtttgctctg aacatggcct tgataacaaa atttacccta aaaatactaa 4680 aaagaaacgt gtagaccttc caaaatgtga cagtggctgt gctgagacct tgtttggcct 4740 taagaacatt ttttccccat ctgaagactt attttcattt ttaaagcaca aaatcacaat 4800 gaaggaagaa tggcataaat tcatccagct tcttacagaa ttccaaatgc ggaatgtaga 4860 ttttttatat agtaatcttg agtttattct accattacca gttgatacca ttccagaaac 4920 taaaaacttt tgtggcccat cagtaactgt ggatgccagt gcagcaacaa aaagtatgaa 4980 ttgtcttgct aggaaacact ctgaaagaga acagccattg aaaaagtccc agaaaaagaa 5040 acaaaagaaa acattggtaa tattagatga tagtgatcta tttgacactg acttggactt 5100 tcctgatcaa tctattagcc tgtcctctgt atcatcttcc tcaaatgcag aagaaagcaa 5160 aaccggagac gaagaaagca aagccagaga caaaggaaac aatccagaga caaagaaatc 5220 tattccttgt cctcctaaaa caactgcagg aaaaaaatgt tctgcccttg tttctcattg 5280 tttaaattct ctctctgagt tcatggataa catgtccttc ttagatgcac ttttaactga 5340 tgtaagggaa caaaacaaat acggtagaaa tgactttagt tggacaaatg gaaaggttac 5400 aagtggactt tgtgatgagt ttagtcttga gagtaatgat ggatggactt ctcaaagctc 5460 tggagaatta aaggcagctg cagaagctct cagctttact aaatgttctt ctgctatttc 5520 aaaagcattg gaaaccttga attcttgcaa gaaattagga agagatccaa ccaacgatct 5580 tactttttat gtttcacaaa agcgcaataa tgtatacttt agtcagtcag cagctaattt 5640 agacaatgct tggaagagga tatcagtcat taaaagtgta ttttcgagtc gatctcttct 5700 ctatgtgggt aatagacaag ctagtataat tgaatacctg ccaacccttc gaaacatctg 5760 taagactgag aagctaaaag aacaaggaaa aagtaaaaga agattcctgc actattttga 5820 aggaattcat cttgacattc caaaagagac tgtgaatact ttggcagctg acttccctta 5880 atgttccata ctaacaatgc tttgtataga ttatcatgtg gtccttaaga tacattttta 5940 tattatgtgg atcttcatgg aaaagtatat ttctcgatgt acattttaaa caaacaattt 6000 gtatattttt ttattggcgg gtaaatattt aaaatatttg agttacaaat tttatatatg 6060 attgtaattt tttttctgaa ttttttgtat tatctgattt agctttgttg gagtattttt 6120 tgtatgtgag tgaactgttt ctggaaggta gagttcatta agatgaactc cctatttcaa 6180 gtgtttatat tatatattag cttaatattc agatacatta tcttggctgc taacattagt 6240 gtcac 6245 <210> 152 <211> 6245 <212> DNA <213> Homo sapiens <400> 152 tttcctccga agctctgtgg tccgatctgc ggtccgcttg ctttccctgc ccggtcccga 60 gcgctcagcc tgaagcgccg ctttcgaggg caccctgcat acactggccg cgcctcaggg 120 atctcattgc ccgcgctttc tcattgcctc tttccgtgtt cgattcggct gatctgggcc 180 cagcctccgc tcccgctctc tgtcggtggg cgcgggggaa tccgaaacgg ctcagcagaa 240 tcccagcagc ttgctgctac tggagcgggc cgcctccatg gcctccaggc aggccgggct 300 ggaccgcgtg aggtcctagg agacgggatt ccgggaagcg gggagtatgg tgggggtcct 360 ggccatggcg gctgcagctg ctccgcctcc cgtgaaggac tgcgagattg agccatgcaa 420 aaagcgaaag aaagatgatg acacatctac ctgcaaaaca attacaaaat atttatcacc 480 actagggaag actagagaca gggtttttgc tccaccaaaa cctagtaata ttctggatta 540 ttttagaaag acttcaccca caaatgagaa gacacaatta gggaaagagt gcaagataaa 600 gtcacctgaa tcagtacctg ttgacagcaa caaagactgt acgacacctt tggaaatgtt 660 ctcaaatgta gagtttaaga agaaaagaaa gagggttaat ttatctcatc aactaaataa 720 tattaaaact gaaaatgaag ctccaattga aattagtagc gacgatagca aagaagacta 780 tagtttaaat aatgattttg tggaaagtag tacttctgtt ttacgttaca agaaacaagt 840 agaggtactt gcagaaaaca ttcaagatac aaaaagtcaa ccaaatacta tgacctccct 900 gcaaaattct aaaaaagtaa atcctaaaca agggaccaca aaaaatgact tcaaaaagtt 960 gagaaaaagg aaatgcagag atgtagtaga tctatctgaa agcttaccct tggcagagga 1020 actaaatttg cttaaaaaag atggtaaaga tactaaacag atggagaata ctacaagcca 1080 tgcaaactct agagataacg taactgaagc agcccagtta aatgatagta taataactgt 1140 ctcatatgag gaatttttaa aaagtcacaa ggaaaataaa gtggaagaga taccagactc 1200 tacaatgtca atttgtgttc cttctgaaac tgtcgacgaa atagtcaaaa gtggttatat 1260 aagtgaatca gaaaactccg aaatttccca gcaggtacgc tttaagacag ttactgttct 1320 tgcacaggtt caccctattc cgcccaaaaa gacagggaaa ataccccgaa ttttcttgaa 1380 acaaaagcaa tttgaaatgg aaaatagttt atctgatcct gagaatgaac agacagttca 1440 gaaaagaaaa tctaatgttg ttatacagga ggaagaatta gaattggctg ttttggaagc 1500 tggaagttct gaagctgtga aaccaaaatg cactctagaa gaaagacagc aatttatgaa 1560 agcatttagg cagccagcat cagatgcact taaaaatgga gttaaaaagt cttctgataa 1620 gcagaaagac cttaatgaaa aatgtctata tgaagtagga agagatgata attctaaaaa 1680 aatcatggaa aattctggta tccaaatggt ttcaaaaaat ggcaatttac agttacacac 1740 tgataaagga agttttctga aggagaaaaa taaaaagcta aagaagaaga ataagaaaac 1800 attagatact ggggctattc caggcaaaaa cagagaggga aacactcaaa agaaagaaac 1860 aacctttttc ttaaaagaga aacaatatca aaatagaatg agtttaagac aaaggaaaac 1920 agagtttttc aaaagcagca ctttatttaa caatgaaagt cttgtttatg aagatatagc 1980 aaatgatgac cttctaaagg tttcctctct gtgtaacaat aataaattgt caagaaaaac 2040 cagcatacca gttaaagata ttaagcttac acagtctaaa gctgaatctg aagccagctt 2100 gctaaatgtt tccacgccca agtcaactag aagatctgga agaattagca gcacacctac 2160 tacagaaacc attagaggta ttgattctga cgatgtacaa gataatagtc aactaaaggc 2220 ttccactcaa aaagcagcca acttatcgga aaagcacagc ttatatacag cagaattaat 2280 aacagtaccc tttgattcag agagccctat tagaatgaaa ttcaccagaa ttagtactcc 2340 caaaaaatct aagaaaaaat ctaacaaaag atctgagaaa tctgaagcaa ctgatggagg 2400 ttttacttct cagattagaa aggcaagcaa tacttcaaaa aacatatcaa aagcaaaaca 2460 attgattgaa aaagcaaaag ctttacacat cagtaggtca aaggtgactg aagaaatagc 2520 gataccctta aggcgctcct ctagacatca gacacttcct gaaaggaaga aattgtcaga 2580 aacagaagat tctgttataa taatagattc aagtcctact gctttaaagc atccagagaa 2640 aaatcagaag aaacttcagt gtttgaatga tgtgctagga aaaaaactta acacatccac 2700 taaaaatgta cctggaaaaa tgaaagtcgc tcctttattt cttgtcagaa aagcacaaaa 2760 agcagctgat cctgtcccta gttttgatga aagcagtcaa gatacatctg aaaaatctca 2820 ggattgtgat gttcaatgta aagcaaagcg tgacttccta atgagtggtt tgccagattt 2880 gttgaaacgg caaattgcaa agaaagctgc tgcgctggat gtgtacaatg cagtgagtac 2940 cagtttccag agagtcgtac atgtgcaaca aaaggatgat gggtgttgtt tgtggcattt 3000 gaaaccaccc tcttgtcctc tcttaactaa atttaaagaa ctgaacacta aagtaataga 3060 tctctcaaaa tgtggtattg ctcttggtga attttcaaca ttgaattcaa agttgaaaag 3120 cggtaactct gctgctgtgt tcatgaggac aaggaaggaa tttactgaag aagtaagaaa 3180 tcttttgctt gaggaaatta ggtggtcaaa tcctgaattt tcattgaaaa aatattttcc 3240 cttactccta aaaaaacaaa ttgagcacca agtactttct tccgagtgtc atagtaaaca 3300 agaactggag gctgatgtca gccataaaga aaccaaaagg aaactcgtag aagcagaaaa 3360 ttctaagtca aaaagaaaga aaccaaatga gtattcaaaa aatctggaga agaccaatag 3420 gaagtcagaa gaacttagca aaagaaacaa ctcttctggg ataaagctag attcttccaa 3480 agattctgga actgaagaca tgctttggac agaaaagtat caacctcaga ctgccagtga 3540 acttatagga aatgagttag ctataaaaaa gttacatagt tggttgaaag actggaaaag 3600 aagagctgaa ttggaagaaa ggcagaatct gaagggaaaa agagatgaga aacatgaaga 3660 tttctcgggt ggcatagact ttaaaggcag ttcagatgat gaagaagaga gtcgtctttg 3720 caatactgtc cttataacag ggccaacagg agtgggaaaa actgctgcag tgtatgcttg 3780 tgcccaggag cttggattta agatatttga agtgaatgcc tcttcccagc gcagtggtag 3840 acaaattcta tctcagttga aggaagctac tcagtcccat caagtagaca aacaaggtgt 3900 aaactcacaa aaaccctgtt tttttaatag ctactacata ggcaagtcac caaaaaaaat 3960 aagctcccct aagaaagttg ttacatcacc aagaaaagtt cctccaccat caccaaaaag 4020 tagtggacca aagcgagcac ttcctcccaa aaccttggca aattatttta aagtatctcc 4080 caaacctaaa aataatgaag aaataggaat gcttctggaa aataataaag gaataaaaaa 4140 ttcttttgaa cagaaacaaa ttactcagac taaatctaca aatgcaacta attcaaatgt 4200 caaagacgtt ggagctgaag aacccagcag aaaaaatgca acatctctta ttctttttga 4260 ggaggttgat gtaatttttg atgaagatgc tgggtttttg aatgcaatca aaacattcat 4320 ggcaacaact aaacgacctg taatccttac tacaagtgac ccaacattta gtttaatgtt 4380 tgatggctgc tttgaagaaa tcaagttcag tactccttcc ctgctaaatg ttgccagcta 4440 cctacaaatg atttgcttaa ctgagaattt tagaactgat gtaaaagact ttgtaacctt 4500 gttaactgca aatacttgtg atatcagaaa aagtatcctt tacttacaat tctggattag 4560 aagtggaggt ggagttttag aagaacgacc attaaccctt tatcgtggaa atagcagaaa 4620 tgtacaacta gtttgctctg aacatggcct tgataacaaa atttacccta aaaatactaa 4680 aaagaaacgt gtagaccttc caaaatgtga cagtggctgt gctgagacct tgtttggcct 4740 taagaacatt ttttccccat ctgaagactt attttcattt ttaaagcaca aaatcacaat 4800 gaaggaagaa tggcataaat tcatccagct tcttacagaa ttccaaatgc ggaatgtaga 4860 ttttttatat agtaatcttg agtttattct accattacca gttgatacca ttccagaaac 4920 taaaaacttt tgtggcccat cagtaactgt ggatgccagt gcagcaacaa aaagtatgaa 4980 ttgtcttgct aggaaacact ctgaaagaga acagccattg aaaaagtccc agaaaaagaa 5040 acaaaagaaa acattggtaa tattagatga tagtgatcta tttgacactg acttggactt 5100 tcctgatcaa tctattagcc tgtcctctgt atcatcttcc tcaaatgcag aagaaagcaa 5160 aaccggagac gaagaaagca aagccagaga caaaggaaac aatccagaga caaagaaatc 5220 tattccttgt cctcctaaaa caactgcagg aaaaaaatgt tctgcccttg tttctcattg 5280 tttaaattct ctctctgagt tcatggataa catgtccttc ttagatgcac ttttaactga 5340 tgtaagggaa caaaacaaat acggtagaaa tgactttagt tggacaaatg gaaaggttac 5400 aagtggactt tgtgatgagt ttagtcttga gagtaatgat ggatggactt ctcaaagctc 5460 tggagaatta aaggcagctg cagaagctct cagctttact aaatgttctt ctgctatttc 5520 aaaagcattg gaaaccttga attcttgcaa gaaattagga agagatccaa ccaacgatct 5580 tactttttat gtttcacaaa agcgcaataa tgtatacttt agtcagtcag cagctaattt 5640 agacaatgct tggaagagga tatcagtcat taaaagtgta ttttcgagtc gatctcttct 5700 ctatgtgggt aatagacaag ctagtataat tgaatacctg ccaacccttc gaaacatctg 5760 taagactgag aagctaaaag aacaaggaaa aagtaaaaga agattcctgc actattttga 5820 aggaattcat cttgacattc caaaagagac tgtgaatact ttggcagctg acttccctta 5880 atgttccata ctaacaatgc tttgtataga ttatcatgtg gtccttaaga tacattttta 5940 tattatgtgg atcttcatgg aaaagtatat ttctcgatgt acattttaaa caaacaattt 6000 gtatattttt ttattggcgg gtaaatattt aaaatatttg agttacaaat tttatatatg 6060 attgtaattt tttttctgaa ttttttgtat tatctgattt agctttgttg gagtattttt 6120 tgtatgtgag tgaactgttt ctggaaggta gagttcatta agatgaactc cctatttcaa 6180 gtgtttatat tatatattag cttaatattc agatacatta tcttggctgc taacattagt 6240 gtcac 6245 <210> 153 <211> 4195 <212> DNA <213> Homo sapiens <400> 153 ggcaggacgg cgcgaaaacc caattgacaa gaattccctc cgaagctctg tggtccgatc 60 tgcggtccgc ttgctttccc tgcccggtcc cgagcgctca gcctgaagcg ccgctttcga 120 gggcaccctg catacactgg ccgcgcctca gggatctcat tgcccgcgct ttctcattgc 180 ctctttccgt gttcgattcg gctgatctgg gcccagcctc cgctcccgct ctctgtcggt 240 gggcgcgggg gaatccgaaa cggctcagca gaatcccagc agcttgctgc tactggagcg 300 ggccgcctcc atggcctcca ggcaggccgg gctggaccgc gtgaggtcct aggagacggg 360 attccgggaa gcggggagta tggtgggggt cctggccatg gcggctgcag ctgctccgcc 420 tcccgtgaag gactgcgaga ttgagccatg caaaaagcga aagaaagatg atgacacatc 480 tacctgcaaa acaattacaa aatatttatc accactaggg aagactagag acagggtttt 540 tgctccacca aaacctagta atattctgga ttattttaga aagacttcac ccacaaatga 600 gaagacacaa ttagggaaag agtgcaagat aaagtcacct gaatcagtac ctgttgacag 660 cgacaaagac tgtacgacac ctttggaaat gttctcaaat gtagagttta agaagaaaag 720 aaagagggtt aatttatctc atcaactaaa taatattaaa actgaaaatg aagctccaat 780 tgaaattagt agcgacgata gcaaagaaga ctatagttta aataatgatt ttgtggaaag 840 tagtacttct gttttacgtt acaagaaaca agtagaggta cttgcagaaa acattcaaga 900 tacaaaaagt caaccaaata ctatgacctc cctgcaaaat tctaaaaaag taaatcctaa 960 acaagggacc acaaaaaatg acttcaaaaa gttgagaaaa aggaaatgca gagatgtagt 1020 agatctatct gaaagcttac ccttggcaga ggaactaaat ttgcttaaaa aagatggtaa 1080 agatactaaa cagatggaga atactacaag ccatgcaaac tctagagata acgtaactga 1140 agcagcccag ttaaatgata gtataataac tgtctcatat gaggaatttt taaaaagtca 1200 caaggaaaat aaagtggaag agataccaga ctctacaatg tcaatttgtg ttccttctga 1260 aactgtcgac gaaatagtca aaagtggtta tataagtgaa tcagaaaact ccgaaatttc 1320 ccagcaggta cgctttaaga cagttactgt tcttgcacag gttcacccta ttccgcccaa 1380 aaagacaggg aaaatacccc gaattttctt gaaacaaaag caatttgaaa tggaaaatag 1440 tttatctgat cctgagaatg aacagacagt tcagaaaaga aaatctaatg ttgttataca 1500 ggaggaagaa ttagaattgg ctgttttgga agctggaagt tctgaagctg tgaaaccaaa 1560 atgcactcta gaagaaagac agcaatttat gaaagcattt aggcagccag catcagatgc 1620 acttaaaaat ggagttaaaa agtcttctga taagcagaaa gaccttaatg aaaaatgtct 1680 atatgaagta ggaagagatg ataattctaa aaaaatcatg gaaaattctg gtatccaaat 1740 ggtttcaaaa aatggcaatt tacagttaca cgctgataaa ggaagttttc tgaaggagaa 1800 aaataaaaag ctaaagaaga agaataagaa aacattagat actggggcta ttccaggcaa 1860 aaacagagag ggaaacactc aaaagaaaga aacaaccttt ttcttaaaag agaaacaata 1920 tcaaaataga atgagtttaa gacaaaggaa aacagagttt ttcaaaagca gcactttatt 1980 taacaatgaa agtcttgttt atgaagatat agcaaatgat gaccttctaa aggtttcctc 2040 tctgtgtaac aataataaat tgtcaagaaa aaccagcata ccagttaaag atattaagct 2100 tacacagtct aaagctgaat ctgaagccag cttgctaaat gtttccacgc ccaagtcaac 2160 tagaagatct ggaagaatta gcagcacacc tactacagaa accattagag gtactgattc 2220 tgacgatgta caagataata gtcaactaaa ggcttccact caaaaagcag ccaacttatc 2280 ggaaaagcac agcttatata cagcagaatt aataacagta ccctttgatt cagagagccc 2340 tattagaatg aaattcacca gaattagtac tcccaaaaaa tctaagaaaa aatctaacaa 2400 aagatctgag aaatctgaag caactgatgg aggttttact tctcagatta gaaaggcaag 2460 caatacttca aaaaacatat caaaagcaaa acaattgatt gaaaaagcaa aagctttaca 2520 catcagtagg tcaaaggtga ctgaagaaat agcgataccc ttaaggcgct cctctagaca 2580 tcagacactt cctgaaagga agaaattgtc agaaacagaa gattctgtta taataataga 2640 ttcaagtcct actgctttaa agcatccaga gaaaaatcag aagaaacttc agtgtttgaa 2700 tgatgtgcta ggaaaaaaac ttaacacatc cactaaaaat gtacctggaa aaatgaaagt 2760 cgctccttta tttcttgtca gaaaagcaca aaaagcagct gatcctgtcc ctagttttga 2820 tgaaagcagt caagatacat ctgaaaaatc tcaggattgt gatgttcaat gtaaagcaaa 2880 gcgtgacttc ctaatgagtg gtttgccaga tttgttgaaa cggcaaattg caaagaaagc 2940 tgctgcgctg gatgtgtaca atgcagtgag taccagtttc cagagagtcg tacatgtgca 3000 acaaaaggat gatgggtgtt gtttgtggca tttgaaacca ccctcttgtc ctctcttaac 3060 taaatttaaa gaactgaaca ctaaagtaat agatctctca aaatgtggta ttgctcttgg 3120 tgaattttca acattgaatt caaagttgaa aagcggtaac tctgctgctg tgttcatgag 3180 gacaaggaag gaatttactg aagaagtaag aaatcttttg cttgaggaaa ttaggtggtc 3240 aaatcctgaa ttttcattga aaaaatattt tcccttactc ctaaaaaaac aaattgagca 3300 ccaagtactt tcttccgagt gtcatagtaa acaagaactg gaggctgatg tcagccataa 3360 agaaaccaaa aggaaactcg tagaagcaga aaattctaag tcaaaaagaa agaaaccaaa 3420 tgagtattca aaaaatctgg agaagaccaa taggaagtca gaagaactta gcaaaagaaa 3480 caactcttct gggataaagc tagattcttc caaagattct ggaactgaag acatgctttg 3540 gacagaaaag tatcaacctc agactgccag tgaacttata ggaaatgagt tagctataaa 3600 aaagttacat agttggttga aagactggaa aagaagagct gaattggaag aaaggcagaa 3660 tctgaaggga aaaagagatg agaaacatga agatttctcg ggtggcatag actttaaagg 3720 cagttcagat gatgaagaag agagtcgtct ttgcaatact gtccttataa cagggccaac 3780 aggagtggga aaaactgctg cagtgtatgc ttgtgcccag gagcttggat ttaagatatt 3840 tgaagtgaat gcctcttccc agcgcagtgg tagacaaatt ctatctcagt tgaaggaagc 3900 tactcagtcc catcaagtag acaaacaagg tgtaaactca caaaaaccct gtttttttaa 3960 tagctactac ataggcaagt caccaaaaaa aataagctcc cctaagaaag ttgttacatc 4020 accaagaaaa gttcctccac catcaccaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 4080 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 4140 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa 4195 <210> 154 <211> 2545 <212> DNA <213> Homo sapiens <400> 154 agaattagaa ttggctgttt tggaagctgg aagttctgaa gctgtgaaac caaaatgcac 60 tctagaagaa agacagcaat ttatgaaagc atttaggcag ccagcatcag atgcacttaa 120 aaatggagtt aaaaagtctt ctgataagca gaaagacctt aatgaaaaat gtctatatga 180 agtaggaaga gatgataatt ctaaaaaaat catggaaaat tctggtatcc aaatggtttc 240 aaaaaatggc aatttacagt tacacactga taaaggaagt tttctgaagg agaaagataa 300 aaagctaaag aagaagaata agaaaacatt agatactggg gctattccag gcaaaaacag 360 agagggaaac actcaaaaga aagaaacaac ctttttctta aaagagaaac aatatcaaaa 420 tagaatgagt ttaagacaaa ggaaaacaga gtttttcaaa agcagcactt tatttaacaa 480 tgaaagtctt gtttatgaag atatagcaaa tgatgacctt ctaaaggttt cctctctgtg 540 taacaataat aaattgtcaa gaaaaaccag cataccagtt aaagatatta agcttacaca 600 gtctaaagct gaatctgaag ccagcttgct aaatgtttcc acgcccaagt caactagaag 660 atctggaaga attagcagca cacctactac agaaaccatt agaggtattg attctgacga 720 tgtacaagat aatagtcaac taaaggcttc cactcaaaaa gcagccaact tatcggaaaa 780 gcacagctta tatacagcag aattaataac agtacccttt gattcagaga gccctattag 840 aatgaaattc accagaatta gtactcccaa aaaatctaag aaaaaatcta acaaaagatc 900 tgagaaatct gaagcaactg atggaggttt tacttctcag attagaaagg caagcaatac 960 ttcaaaaaac atatcaaaag caaaacaatt gattgaaaaa gcaaaagctt tacacatcag 1020 taggtcaaag gtgactgaag aaatagcgat acccttaagg cgctcctcta gacatcagac 1080 acttcctgaa aggaagaaat tgtcagaaac agaagattct gttataataa tagattcaag 1140 tcctactgct ttaaagcatc cagagaaaaa tcagaagaaa cttcagtgtt tgaatgatgt 1200 gctaggaaaa aaacttaaca catccactaa aaatgtacct ggaaaaatga aagtcgctcc 1260 tttatttctt gtcagaaaag cacaaaaagc agctgatcct gtccctagtt ttgatgaaag 1320 cagtcaagat acatctgaaa aatctcagga ttgtgatgtt caatgtaaag caaagcgtga 1380 cttcctaatg agtggtttgc cagatttgtt gaaacggcaa attgcaaaga aagctgctgc 1440 gctggatgtg tacaatgcag tgagtaccag tttccagaga gtcgtacatg tgcaacaaaa 1500 ggatgatggg tgttgtttgt ggcatttgaa accaccctct tgtcctctct taactaaatt 1560 taaagaactg aacactaaag taatagatct ctcaaaatgt ggtattgctc ttggtgaatt 1620 ttcaacattg aattcaaagt tgaaaagcgg taactctgct gctgtgttca tgaggacaag 1680 gaaggaattt actgaagaag taagaaatct tttgcttgag gaaattaggt ggtcaaatcc 1740 tgaattttca ttgaaaaaat attttccctt actcctaaaa aaacaaattg agcaccaagt 1800 actttcttcc gagtgtcata gtaaacaaga actggaggct gatgtcagcc ataaagaaac 1860 caaaaggaaa ctcgtagaag cagaaaattc taagtcaaaa agaaagaaac caaatgagta 1920 ttcaaaaaat ctggagaaga ccaataggaa gtcagaagaa cttagcaaaa gaaacaactc 1980 ttctgggata aagctagatt cttccaaaga ttctggaact gaagacatgc tttggacaga 2040 aaagtatcaa cctcagactg ccagtgaact tataggaaat gagttagcta taaaaaagtt 2100 acatagttgg ttgaaagact ggaaaagaag agctgaattg gaagaaaggc agaatctgaa 2160 gggaaaaaga gatgagaaac atgaagattt ctcgggtggc atagacttta aaggcagttc 2220 agatgatgaa gaagagagtc gtctttgcaa tactgtcctt ataacagggc caacaggagt 2280 gggaaaaact gctgcagtgt atgcttgtgc ccaggagctt ggatttaaga tatttgaagt 2340 gaatgcctct tcccagcgca gtggtagaca aattctatct cagttgaagg aagctactca 2400 gtcccatcaa gtagacaaac aaggtgtaaa ctcacaaaaa ccctgttttt ttaatagcta 2460 ctacataggc aagtcaccaa gtaagtaaac tattttcctt aagccataat gttttgaaaa 2520 aaataaaatc taagaaagta atgtt 2545 <210> 155 <211> 1801 <212> DNA <213> Homo sapiens <400> 155 cgaaaaccca attgacaaga attccctccg aagctctgtg gtccgatctg cggtccgctt 60 gctttccctg cccggtcccg agcgctcagc ctgaagcgcc gctttcgagg gcaccctgca 120 tacactggcc gcgcctcagg gatctcattg cccgcgcttt ctcattgcct ctttccgtgt 180 tcgattcggc tgatctgggc ccagcctccg ctcccgctct ctgtcggtgg gcgcggggga 240 atccgaaacg gctcagcaga atcccagcag cttgctgcta ctggagcggg ccgcctccat 300 ggcctccagg caggccgggc tggaccgcgt gaggtcctag gagacgggat tccgggaagc 360 ggggagtatg gtgggggtcc tggccatggc ggctgcagct gctccgcctc ccgtgaagga 420 ctgcgagatt gagccatgca aaaagcgaaa gaaagatgat gacacatcta cctgcaaaac 480 aattacaaaa tatttatcac cactagggaa gactagagac agggtttttg ctccaccaaa 540 acctagtaat attctggatt attttagaaa gacttcaccc acaaatgaga agacacaatt 600 agggaaagag tgcaagataa agtcacctga atcagtacct gttgacagca acaaagactg 660 tacgacacct ttggaaatgt tctcaaatgt agagtttaag aagaaaagaa agagggttaa 720 tttatctcat caactaaata atattaaaac tgaaaatgaa gctccaattg gaattagtag 780 cgacgatagc aaagaagact atagtttaaa taatgatttt gtggaaagta gtacttctgt 840 tttacgttac aagaaacaag tagaggtact tgcagaaaac attcaagata caaaaagtca 900 accaaatact atgacctccc tgcaaaattc taaaaaagta aatcctaaac aagggaccac 960 aaaaaatgac ttcaaaaagt tgagaaaaag gaaatgcaga gatgtagtag atctatctga 1020 aagcttaccc ttggcagagg aactaaattt gcttaaaaaa gatggtaaag atactaaaca 1080 gatggagaat actacaagcc atgcaaactc tagagataac gtaactgaag cagcccagtt 1140 aaatgatagt ataataactg tctcatatga ggaattttta aaaagtcaca aggaaaataa 1200 agtggaagag ataccagact ctacaatgtc aatttgtgtt ccttctgaaa ctgtcgacga 1260 aatagtcaaa agtggttata taagtgaatc agaaaactcc gaaatttccc agcaggtacg 1320 ctttaagaca gttactgttc ttgcacaggt tcaccctatt ccgcccaaaa agacagggaa 1380 aataccccga attttcttga aacaaaagca atttgaaatg gaaaatagtt tatctgatcc 1440 tgagaatgaa cagacagttc agaaaagaaa atctaatgtt gttatacagg aggaagaatt 1500 agaattggct gttttggaag ctggaagttc tgaagctgtg aaaccaaaat gcactctaga 1560 agaaagacag caatttatga aagcatttag gcagccagca tcagatgcac ttaaaaatgg 1620 agttaaaaag tcttctgata agcagaaaga ccttaatgaa aaatgtctat atgaagtagg 1680 aagagatgat aattctaaaa aaatcatgga aaattctggt atccaaatgg tttcaaaaaa 1740 tggcaattta cagttacaca ctgataaagg aagttttctg aaggagaaaa aaaaaaaaaa 1800 a 1801 <210> 156 <211> 2265 <212> DNA <213> Homo sapiens <400> 156 agtcctgcga tttcgggtgt agagggagca ggggcctgcg gggacctggt gtgggtggag 60 tggggacaag cggtggagaa gggtacgcca gggtcgctga gagactctgt tctccctgga 120 gggactggtt gccatgagag cagccgtctg aggggacgca gcctgcacta cgcgccccaa 180 gaggctgtgc gtggcgagca ggtcacgtga cgggagcgcg ggctttggaa ggcggctgaa 240 cgtcaggcca cccgccgcta agctgagaag ggagagcgag cttaggaccg cctgcccggg 300 gcaaccccga accaagcttt agccgccgag gccgcgtgtc ccaaaggcca gtcatccctc 360 ctctgtgttg ccatgggaat tcaaggcctg gccaaactaa ttgctgatgt ggcccccagt 420 gccatccggg agaatgacat caagagctac tttggccgta aggtggccat tgatgcctct 480 atgagcattt atcagttcct gattgctgtt cgccagggtg gggatgtgct gcagaatgag 540 gagggtgaga ccaccagcca cctgatgggc atgttctacc gcaccattcg catgatggag 600 aacggcatca agcccgtgta tgtctttgat ggcaagccgc cacagctcaa gtcaggcgag 660 ctggccaaac gcagtgagcg gcgggctgag gcagagaagc agctgcagca ggctcaggct 720 gctggggccg agcaggaggt ggaaaaattc actaagcggc tggtgaaggt cactaagcag 780 cacaatgatg agtgcaaaca tctgctgagc ctcatgggca tcccttatct tgatgcaccc 840 agtgaggcag aggccagctg tgctgccctg gtgaaggctg gcaaagtcta tgctgcggct 900 accgaggaca tggactgcct caccttcggc agccctgtgc taatgcgaca cctgactgcc 960 agtgaagcca aaaagctgcc aatccaggaa ttccacctga gccggattct gcaggagctg 1020 ggcctgaacc aggaacagtt tgtggatctg tgcatcctgc taggcagtga ctactgtgag 1080 agtatccggg gtattgggcc caagcgggct gtggacctca tccagaagca caagagcatc 1140 gaggagatcg tgcggcgact tgaccccaac aagtaccctg tgccagaaaa ttggctccac 1200 aaggaggctc accagctctt cttggaacct gaggtgctgg acccagagtc tgtggagctg 1260 aagtggagcg agccaaatga agaagagctg atcaagttca tgtgtggtga aaagcagttc 1320 tctgaggagc gaatccgcag tggggtcaag aggctgagta agagccgcca aggcagcacc 1380 cagggccgcc tggatgattt cttcaaggtg accggctcac tctcttcagc taagcgcaag 1440 gagccagaac ccaagggatc cactaagaag aaggcaaaga ctggggcagc agggaagttt 1500 aaaaggggaa aataaatgtg tttccccatt atacctcctt caccccagaa tatttgccgt 1560 cttgtaccct taagagctac agctagagaa accttcacgg ggtggagaga ggattctaag 1620 gcttttctag cgtgaccctt ttcagtagtg ctagtccctt ttttacttga tcttaatggc 1680 aagaaggcca cagaggtact tttccttttt tagctcagga aaatatgtca ggctcaaacc 1740 acttctcagg cagtttaatg gacactaagt ccattgttac atgaaagtga tagatagcaa 1800 caagttttgg agaagagaga gggagataaa agggggagac aaaagatgta cagaaatgat 1860 ttcctggctg gccaactggt ggccagtggg aggtgatggt ggacctagac tgtgcttttc 1920 tgtcttgttc agccttgacc caccttgaga gagagccacc aggaaggcgc atcttagcag 1980 atgggaggaa ctgctgagag aagatgggca gaaagctgga gcccctggag ttggctgtgt 2040 ctgtgtttgt gactgattac tggctgtgtc ttgggtgggc agaaactcga acttgctatg 2100 taatttgtgt ctagttattc agaggagtaa gatggtgatg ttcacctggc aatcagctga 2160 gttgagactt tggaataaga cactggtttt catgcgctgt ttttgtttta aagttatgaa 2220 gaaaaaagtc aataaaattc taaaagtaaa aaaaaaaaaa aaaaa 2265 <210> 157 <211> 2022 <212> DNA <213> Homo sapiens <400> 157 caggccaccc gccgctaagc tgagaaggga gagcgagctt aggaccgcct gcccggggca 60 accccgaacc aagctttagc cgccgaggcc gcgtgtccca aaggccagtc atccctcctc 120 tgtgttgcca tgggaattca aggcctggcc aaactaattg ctgatgtggc ccccagtgcc 180 atccgggaga atgacatcaa gagctacttt ggccgtaagg tggccattga tgcctctatg 240 agcatttatc agttcctgat tgctgttcgc cagggtgggg atgtgctgca gaatgaggag 300 ggtgagacca ccagccacct gatgggcatg ttctaccgca ccattcgcat gatggagaac 360 ggcatcaagc ccgtgtatgt ctttgatggc aagccgccac agctcaagtc aggcgagctg 420 gccaaacgca gtgagcggcg ggctgaggca gagaagcagc tgcagcaggc tcaggctgct 480 ggggccgagc aggaggtgga aaaattcact aagcggctgg tgaaggtcac taagcagcac 540 aatgatgagt gcaaacatct gctgagcctc atgggcatcc cttatcttga tgcacccagt 600 gaggcagagg ccagctgtgc tgccctggtg aaggctggca aagtctatgc tgcggctacc 660 gaggacatgg actgcctcac cttcggcagc cctgtgctaa tgcgacacct gactgccagt 720 gaagccaaaa agctgccaat ccaggaattc cacctgagcc ggattctgca ggagctgggc 780 ctgaaccagg aacagtttgt ggatctgtgc atcctgctag gcagtgacta ctgtgagagt 840 atccggggta ttgggcccaa gcgggctgtg gacctcatcc agaagcacaa gagcatcgag 900 gagatcgtgc ggcgacttga ccccaacaag taccctgtgc cagaaaattg gctccacaag 960 gaggctcacc agctcttctt ggaacctgag gtgctggacc cagagtctgt ggagctgaag 1020 tggagcgagc caaatgaaga agagctgatc aagttcatgt gtggtgaaaa gcagttctct 1080 gaggagcgaa tccgcagtgg ggtcaagagg ctgagtaaga gccgccaagg cagcacccag 1140 ggccgcctgg atgatttctt caaggtgacc ggctcactct cttcagctaa gcgcaaggag 1200 ccagaaccca agggatccac taagaagaag gcaaagactg gggcagcagg gaagtttaaa 1260 aggggaaaat aaatgtgttt ccccattata cctccttcac cccagaatat ttgccgtctt 1320 gtacccttaa gagctacagc tagagaaacc ttcacggggt ggagagagga ttctaaggct 1380 tttctagcgt gacccttttc agtagtgcta gtcccttttt tacttgatct taatggcaag 1440 aaggccacag aggtactttt ccttttttag ctcaggaaaa tatgtcaggc tcaaaccact 1500 tctcaggcag tttaatggac actaagtcca ttgttacatg aaagtgatag atagcaacaa 1560 gttttggaga agagagaggg agataaaagg gggagacaaa agatgtacag aaatgatttc 1620 ctggctggcc aactggtggc cagtgggagg tgatggtgga cctagactgt gcttttctgt 1680 cttgttcagc cttgacccac cttgagagag agccaccagg aaggcgcatc ttagcagatg 1740 ggaggaactg ctgagagaag atgggcagaa agctggagcc cctggagttg gctgtgtctg 1800 tgtttgtgac tgattactgg ctgtgtcttg ggtgggcaga aactcgaact tgctatgtaa 1860 tttgtgtcta gttattcaga ggagtaagat ggtgatgttc acctggcaat cagctgagtt 1920 gagactttgg aataagacac tggttttcat gcgctgtttt tgttttaaag ttatgaagaa 1980 aaaagtcaat aaaattctaa aagtaaaaaa aaaaaaaaaa aa 2022 <210> 158 <211> 1757 <212> DNA <213> Homo sapiens <400> 158 agtcctgcga tttcggtgta gaggagcagg ggctgcggga cctggtgtgg gtggagtggg 60 acaagcggtg gagaagggta cgccagggtc gctgagagac tctgttctcc ctggagggac 120 tggttgccat gagagcagcc gtctgagggg acgcagcctg cactacgcgc cccaagaggc 180 tgtgcgtggc gagcaggtca cgtgacggga gcgcgggctt tggaaggcgg ctgaacgtca 240 ggccacccgc cgctaagctg agaagggaga gcgagcttag gaccgcctgc ccggggcaac 300 cccgaaccaa gctttagccg ccgaggccgc gtgtcccaaa ggccagtcat ccctcctctg 360 tgttgccatg ggaattcaag gcctggccaa actaattgct gatgtggccc ccagtgccat 420 ccgggagaat gacatcaaga gctactttgg ccgtaaggtg gccattgatg cctctatgag 480 catttatcag ttcctgattg ctgttcgcca gggtggggat gtgctgcaga atgaggaggg 540 tgagaccacc agccacctga tgggcatgtt ctaccgcacc attcgcatga tggagaacgg 600 catcaagccc gtgtatgtct ttgatggcaa gccgccacag ctcaagtcag gcgagctggc 660 caaacgcagt gagcggcggg ctgaggcaga gaagcagctg cagcaggctc aggctgctgg 720 ggccgagcag gaggtggaaa aattcactaa gcggctggtg aaggtcacta agcagcacaa 780 tgatgagtgc aaacatctgc tgagcctcat gggcatccct tatcttgatg cacccagtga 840 ggcagaggcc agctgtgctg ccctggtgaa ggctggcaaa gtctatgctg cggctaccga 900 ggacatggac tgcctcacct tcggcagccc tgtgctaatg cgacacctga ctgccagtga 960 agccaaaaag ctgccaatcc aggaattcca cctgagccgg attctgcagg agctgggcct 1020 gaaccaggaa cagtttgtgg atctgtgcat cctgctaggc agtgactact gtgagagtat 1080 ccggggtatt gggcccaagc gggctgtgga cctcatccag aagcacaaga gcatcgagga 1140 gatcgtgcgg cgacttgacc ccaacaagta ccctgtgcca gaaaattggc tccacaagga 1200 ggctcaccag ctcttcttgg aacctgaggt gctggaccca gagtctgtgg agctgaagtg 1260 gagcgagcca aatgaagaag agctgatcaa gttcatgtgt ggtgaaaagc agttctctga 1320 ggagcgaatc cgcagtgggg tcaagaggct gagtaagagc cgccaaggca gcacccaggg 1380 ccgcctggat gatttcttca aggtgaccgg ctcactctct tcagctaagc gcaaggagcc 1440 agaacccaag ggatccacta agaagaaggc aaagactggg gcagcaggga agtttaaaag 1500 gggaaaataa atgtgtttcc ccattatacc tccttcaccc cagaatattt gccgtcttgt 1560 acccttaaga gctacagcta gagaaacctt cacggggtgg agagaggatt ctaaggcttt 1620 tctagcgtga cccttttcag tagtgctagt ccctttttta cttgatctta atggcaagaa 1680 ggccacagag gtacttttcc tttttttagc tcaggaaaat atgtcaggct caaaccactt 1740 ctcaggcagt ttaatgg 1757 <210> 159 <211> 1144 <212> DNA <213> Homo sapiens <400> 159 atgggaattc aaggcctggc caaactaatt gctgatgtgg cccccagtgc catccgggag 60 aatgacatca agagctactt tggccgtaag gtggccattg atgcctctat gagcatttat 120 cagttcctga ttgctgttcg ccagggtggg gatgtgctgc agaatgagga gggtgagacc 180 accagccacc tgatgggcat gttctaccgc accattcgca tgatggagaa cggcatcaag 240 cccgtgtatg tctttgatgg caagccgcca cagctcaagt caggcgagct ggccaaacgc 300 agtgagcggc gggctgaggc agagaagcag ctgcagcagg ctcaggctgc tggggccgag 360 caggaggtgg aaaaattcac taagcggctg gtgaaggtca ctaagcagca caatgatgag 420 tgcaaacatc tgctgagcct catgggcatc ccttatcttg atgcacccag tgaggcagag 480 gccagctgtg ctgccctggt gaaggctggc aaagtctatg ctgcggctac cgaggacatg 540 gactgcctca ccttcggcag ccctgtgcta atgcgacacc tgactgccag tgaagccaaa 600 aagctgccaa tccaggaatt ccacctgagc cggattctgc aggagctggg cctgaaccag 660 gaacagtttg tggatctgtg catcctgcta ggcagtgact actgtgagag tatccggggt 720 attgggccca agcgggctgt ggacctcatc cagaagcaca agagcatcga ggagatcgtg 780 cggcgacttg accccaacaa gtaccctgtg ccagaaaatt ggctccacaa ggaggctcac 840 cagctcttct tggaacctga ggtgctggac ccagagtctg tggagctgaa gtggagcgag 900 ccaaatgaag aagagctgat caagttcatg tgtggtgaaa agcagttctc tgaggagcga 960 atccgcagtg gggtcaagag gctgagtaag agccgccaag gcagcaccca gggccgcctg 1020 gatgatttct tcaaggtgac cggctcactc tcttcagcta agcgcaagga gccagaaccc 1080 aagggatcca ctaagaagaa ggcaaagact ggggcagcag ggaagtttaa aaggggaaaa 1140 taaa 1144 <210> 160 <211> 591 <212> DNA <213> Homo sapiens <400> 160 ccagggcaac cctgaatcaa gctttagccg ccgaggcctc gtgtcccaaa ggccagtcat 60 ccctcctctg tgttgccatg ggtattcaag gcctggccaa actaattgct gatgtggccc 120 ccagtgccac ccgggagaat gacatcaaga gctactttgg ccgtaaggtg gccattgatg 180 cctctatgag cacttatcag ttcctgattg ctgttcgcca gggtggggat gtgctgcaga 240 acgaggaggg tgagaccacc agccacctga taggcatgtt ctaccgcact attcgcgtga 300 tggagaacgg catcaagccc atgtatgtct ttgagggcac gccaccacag cacaagtcag 360 gcgagctggc caaatgcagt gaactgcggg gctgaggcag agaagcagct acagcaggct 420 caggctgctg gggccgagca ggtggtggaa aaattcacta agtggctggt gaaggtcact 480 aagcagcaca acgatgattt cttcaaggtg actggctcac tctcttcagc taagtgcaag 540 gagccagaat caaagggatc cactaagaag aaggcaaaga ctggggcagc a 591 <210> 161 <211> 4207 <212> DNA <213> Homo sapiens <400> 161 ccccggttcc gctgtctttt ctgtctacag tttgcgatcc ccgcgtccag gatggagcag 60 ctgaacgaac tggagctgct gatggagaag agtttttggg aggaggcgga gctgccggcg 120 gagctatttc agaagaaagt ggtagcttcc tttccaagaa cagttctgag cacaggaatg 180 gataaccggt acctggtgtt ggcagtcaat actgtacaga acaaagaggg aaactgtgaa 240 aagcgcctgg tcatcactgc ttcacagtca ctagaaaata aagaactatg catccttagg 300 aatgactggt gttctgttcc agtagagcca ggagatatca ttcatttgga gggagactgc 360 acatctgaca cttggataat agataaagat tttggatatt tgattctgta tccagacatg 420 ctgatttctg gcaccagcat agccagtagt attcgatgta tgagaagagc tgtcctgagt 480 gaaactttta ggagctctga tccagccaca cgccaaatgc taattggtac ggttctccat 540 gaggtgtttc aaaaagccat aaataatagc tttgccccag aaaagctaca agaacttgct 600 tttcaaacaa ttcaagaaat aagacatttg aaggaaatgt accgcttaaa tctaagtcaa 660 gatgaaataa aacaagaagt agaggactat cttccttcgt tttgtaaatg ggcaggagat 720 ttcatgcata aaaacacttc gactgacttc cctcagatgc agctctctct gccaagtgat 780 aatagtaagg ataattcaac atgtaacatt gaagtcgtga aaccaatgga tattgaagaa 840 agcatttggt cccctaggtt tggattgaaa ggcaaaatag atgttacagt tggtgtgaaa 900 atacatcgag ggtataaaac aaaatacaag ataatgccgc tggaacttaa aactggcaaa 960 gaatcaaatt ctattgaaca ccgtagtcag gttgttctgt acactctact aagccaagag 1020 agaagagctg atccagaggc tggcttgctt ctctacctca agactggtca gatgtaccct 1080 gtgcctgcca accatctaga taaaagagaa ttattaaagc taagaaacca gatggcattc 1140 tcattgtttc accgtattag caaatctgct actagacaga agacacagct tgcttctttg 1200 ccacaaataa ttgaggaaga gaaaacttgt aaatattgtt cacaaattgg caattgtgct 1260 ctttatagca gagcagttga acaacagatg gattgtagtt cagtcccaat tgtgatgctg 1320 cccaaaatag aagaagaaac ccagcatctg aagcaaacac acttagaata tttcagcctt 1380 tggtgtctaa tgttaaccct ggagtcacaa tcgaaggata ataaaaagaa tcaccaaaat 1440 atctggctaa tgcctgcttc ggaaatggag aagagtggca gttgcattgg aaacctgatt 1500 agaatggaac atgtaaagat agtttgtgat gggcaatatt tacataattt ccaatgtaaa 1560 catggtgcca tacctgtcac aaatctaatg gcaggtgaca gagttattgt aagtggagaa 1620 gaaaggtcac tgtttgcttt gtctagagga tatgtgaagg agattaacat gacaacagta 1680 acttgtttat tagacagaaa cttgtcggtc cttccagaat caactttgtt cagattagac 1740 caagaagaaa aaaattgtga tatagatacc ccattaggaa atctttccaa attgatggaa 1800 aacacgtttg tcagcaaaaa acttcgagat ttaattattg actttcgtga acctcagttt 1860 atatcctacc ttagttctgt tcttccacat gatgcaaagg atacagttgc ctgcattcta 1920 aagggtttga ataagcctca gaggcaagcg atgaaaaagg tacttctttc aaaagactac 1980 acactcatcg tgggtatgcc tgggacagga aaaacaacta cgatatgtac tctcgtaaga 2040 attctctacg cctgtggttt tagcgttttg ttgaccagct atacacactc tgctgttgac 2100 aatattcttt tgaagttagc caagtttaaa ataggatttt tgcgtttggg tcagattcag 2160 aaggttcatc cagctatcca gcaatttaca gagcaagaaa tttgcagatc aaagtccatt 2220 aaatccttag ctcttctaga agaactctac aatagtcaac ttatagttgc aacaacatgt 2280 atgggaataa accatccaat attttcccgt aaaatttttg atttttgtat tgtggatgaa 2340 gcctctcaaa ttagccaacc aatttgtctg ggcccccttt ttttttcacg gagatttgtg 2400 ttagtggggg accatcagca gcttcctccc ctggtgctaa accgtgaagc aagagctctt 2460 ggcatgagtg aaagcttatt caagaggctg gagcagaata agagtgctgt tgtacagtta 2520 accgtgcagt acagaatgaa cagtaaaatt atgtccttaa gtaataagct gacctatgag 2580 ggcaagctgg agtgtggatc agacaaagtg gccaatgcag tgataaacct acgtcacttt 2640 aaagatgtga agctggaact ggaattttat gctgactatt ctgataatcc ttggttgatg 2700 ggagtatttg aacccaacaa tcctgtttgt ttccttaata cagacaaggt tccagcgcca 2760 gaacaagttg aaaaaggtgg tgtgagcaat gtaacagaag ccaaactcat agttttccta 2820 acctccattt ttgttaaggc tggatgcagt ccctctgata ttggtattat tgcaccgtac 2880 aggcagcaat taaagatcat caatgattta ttggcacgtt ctattgggat ggtcgaagtt 2940 aatacagtag acaaatacca aggaagggac aaaagtattg tcctagtatc ttttgttaga 3000 agtaataagg atggaactgt tggtgaactc ttgaaagatt ggcgacgtct taatgttgct 3060 ataaccagag ccaaacataa actgattctt ctggggtgtg tgccctcact aaattgctat 3120 cctcctttgg agaagctgct taatcattta aactcagaaa aattaatcat tgatcttcca 3180 tcaagagaac atgaaagtct ttgccacata ttgggtgact ttcaaagaga ataaaacact 3240 atttcccttg ccttttcata ctagggcagt atctcctcta gctagtgccc atacagaaaa 3300 ttctatcacc atacaaaatt taatgcagta tttatgtttt aaagcacagg tgtaccgaaa 3360 actgtgaaaa gtctgaattt atgggttcta tgcatgcatt tttgcctaac ctagagaaag 3420 agtttgataa atttttacca gctttgaaga tggattaact tttgactttg agctttaaac 3480 ttttaagtca gacatttcag gactaatttg attttgtaga tatcattgta agaactttat 3540 ttgaaagact gaataaaggg atttgatttg ttttcatcat ttaagcacag tcttgtgatg 3600 atgagaacat aagtgtgatt cttttctgta ttttgaggtc cctaatccaa agcccatttt 3660 gctaggattt tttctgctat cagatgtgtt ttcactctaa acctagtctt ttatgacatg 3720 aattgattac ttcctgttaa ttttctatcc tcccttacta tcctcctttt ttgttttcag 3780 tattcagtat ttcagtattc tagagtagat tttgatataa aagaaaataa ttcttacatc 3840 atcttttgca acaaattttg ttttctgaat tgataataaa tttaaaaagt tgattcctat 3900 tttcacatat gttcatatgc ccctatgttt gggggtatca ctcagttttc ccttttttgt 3960 gtaaagatgt tttgtaaaac aaaattgtct caaagtgatt atattatata tataaaaagt 4020 aacagatttt aacaaaggtt aaaagattct tggggtaaca gattcttctg gggttggaaa 4080 tcttccattt ctcttgaggg ttttttttaa tgagtgttaa atatgttaaa atttttattt 4140 ctacctcatg tgttttttta aattattact tgaagttttt tatttaataa attttttcta 4200 ctaatgg 4207 <210> 162 <211> 4253 <212> DNA <213> Homo sapiens <400> 162 atgggacagt ggtctggttt ccagattgat aactttctgt gttacccccg gttccgctgt 60 cttttctgtc tacagtttgc gatccccgcg tccaggatgg agcagctgaa cgaactggag 120 ctgctgatgg agaagagttt ttgggaggag gcggagctgc cggcggagct atttcagaag 180 aaagtggtag cttcctttcc aagaacagtt ctgagcacag gaatggataa ccggtacctg 240 gtgttggcag tcaatactgt acagaacaaa gagggaaact gtgaaaagcg cctggtcatc 300 actgcttcac agtcactaga aaataaagaa ctatgcatcc ttaggaatga ctggtgttct 360 gttccagtag agccaggaga tatcattcat ttggagggag actgcacatc tgacacttgg 420 ataatagata aagattttgg atatttgatt ctgtatccag acatgctgat ttctggcacc 480 agcatagcca gtagtattcg atgtatgaga agagctgtcc tgagtgaaac ttttaggagc 540 tctgatccag ccacacgcca aatgctaatt ggtacggttc tccatgaggt gtttcaaaaa 600 gccataaata atagctttgc cccagaaaag ctacaagaac ttgcttttca aacaattcaa 660 gaaataagac atttgaagga aatgtaccgc ttaaatctaa gtcaagatga aataaaacaa 720 gaagtagagg actatcttcc ttcgttttgt aaatgggcag gagatttcat gcataaaaac 780 acttcgactg acttccctca gatgcagctc tctctgccaa gtgataatag taaggataat 840 tcaacatgta acattgaagt cgtgaaacca atggatattg aagaaagcat ttggtcccct 900 aggtttggat tgaaaggcaa aatagatgtt acagttggtg tgaaaataca tcgagggtat 960 aaaacaaaat acaagataat gccgctggaa cttaaaactg gcaaagaatc aaattctatt 1020 gaacaccgta gtcaggttgt tctgtacact ctactaagcc aagagagaag agctgatcca 1080 gaggctggct tgcttctcta cctcaagact ggtcagatgt accctgtgcc tgccaaccat 1140 ctagataaaa gagaattatt aaagctaaga aaccagatgg cattctcatt gtttcaccgt 1200 attagcaaat ctgctactag acagaagaca cagcttgctt ctttgccaca aataattgag 1260 gaagagaaaa cttgtaaata ttgttcacaa attggcaatt gtgctcttta tagcagagca 1320 gttgaacaac agatggattg tagttcagtc ccaattgtga tgctgcccaa aatagaagaa 1380 gaaacccagc atctgaagca aacacactta gaatatttca gcctttggtg tctaatgtta 1440 accctggagt cacaatcgaa ggataataaa aagaatcacc aaaatatctg gctaatgcct 1500 gcttcggaaa tggagaagag tggcagttgc attggaaacc tgattagaat ggaacatgta 1560 aagatagttt gtgatgggca atatttacat aatttccaat gtaaacatgg tgccatacct 1620 gtcacaaatc taatggcagg tgacagagtt attgtaagtg gagaagaaag gtcactgttt 1680 gctttgtcta gaggatatgt gaaggagatt aacatgacaa cagtaacttg tttattagac 1740 agaaacttgt cggtccttcc agaatcaact ttgttcagat tagaccaaga agaaaaaaat 1800 tgtgatatag ataccccatt aggaaatctt tccaaattga tggaaaacac gtttgtcagc 1860 aaaaaacttc gagatttaat tattgacttt cgtgaacctc agtttatatc ctaccttagt 1920 tctgttcttc cacatgatgc aaaggataca gttgcctgca ttctaaaggg tttgaataag 1980 cctcagaggc aagcgatgaa aaaggtactt ctttcaaaag actacacact catcgtgggt 2040 atgcctggga caggaaaaac aactacgata tgtactctcg taagaattct ctacgcctgt 2100 ggttttagcg ttttgttgac cagctataca cactctgctg ttgacaatat tcttttgaag 2160 ttagccaagt ttaaaatagg atttttgcgt ttgggtcaga ttcagaaggt tcatccagct 2220 atccagcaat ttacagagca agaaatttgc agatcaaagt ccattaaatc cttagctctt 2280 ctagaagaac tctacaatag tcaacttata gttgcaacaa catgtatggg aataaaccat 2340 ccaatatttt cccgtaaaat ttttgatttt tgtattgtgg atgaagcctc tcaaattagc 2400 caaccaattt gtctgggccc cctttttttt tcacggagat ttgtgttagt gggggaccat 2460 cagcagcttc ctcccctggt gctaaaccgt gaagcaagag ctcttggcat gagtgaaagc 2520 ttattcaaga ggctggagca gaataagagt gctgttgtac agttaaccgt gcagtacaga 2580 atgaacagta aaattatgtc cttaagtaat aagctgacct atgagggcaa gctggagtgt 2640 ggatcagaca aagtggccaa tgcagtgata aacctacgtc actttaaaga tgtgaagctg 2700 gaactggaat tttatgctga ctattctgat aatccttggt tgatgggagt atttgaaccc 2760 aacaatcctg tttgtttcct taatacagac aaggttccag cgccagaaca agttgaaaaa 2820 ggtggtgtga gcaatgtaac agaagccaaa ctcatagttt tcctaacctc catttttgtt 2880 aaggctggat gcagtccctc tgatattggt attattgcac cgtacaggca gcaattaaag 2940 atcatcaatg atttattggc acgttctatt gggatggtcg aagttaatac agtagacaaa 3000 taccaaggaa gggacaaaag tattgtccta gtatcttttg ttagaagtaa taaggatgga 3060 actgttggtg aactcttgaa agattggcga cgtcttaatg ttgctataac cagagccaaa 3120 cataaactga ttcttctggg gtgtgtgccc tcactaaatt gctatcctcc tttggagaag 3180 ctgcttaatc atttaaactc agaaaaatta atcattgatc ttccatcaag agaacatgaa 3240 agtctttgcc acatattggg tgactttcaa agagaataaa acactatttc ccttgccttt 3300 tcatactagg gcagtatctc ctctagctag tgcccataca gaaaattcta tcaccataca 3360 aaatttaatg cagtatttat gttttaaagc acaggtgtac cgaaaactgt gaaaagtctg 3420 aatttatggg ttctatgcat gcatttttgc ctaacctaga gaaagagttt gataaatttt 3480 taccagcttt gaagatggat taacttttga ctttgagctt taaactttta agtcagacat 3540 ttcaggacta atttgatttt gtagatatca ttgtaagaac tttatttgaa agactgaata 3600 aagggatttg atttgttttc atcatttaag cacagtcttg tgatgatgag aacataagtg 3660 tgattctttt ctgtattttg aggtccctaa tccaaagccc attttgctag gattttttct 3720 gctatcagat gtgttttcac tctaaaccta gtcttttatg acatgaattg attacttcct 3780 gttaattttc tatcctccct tactatcctc cttttttgtt ttcagtattc agtatttcag 3840 tattctagag tagattttga tataaaagaa aataattctt acatcatctt ttgcaacaaa 3900 ttttgttttc tgaattgata ataaatttaa aaagttgatt cctattttca catatgttca 3960 tatgccccta tgtttggggg tatcactcag ttttcccttt tttgtgtaaa gatgttttgt 4020 aaaacaaaat tgtctcaaag tgattatatt atatatataa aaagtaacag attttaacaa 4080 aggttaaaag attcttgggg taacagattc ttctggggct tggaaatctt ccatttctct 4140 tgagggtttt ttttaatgag tgttaaatat gttaaaattt ttatttctac ctcatgtgtt 4200 tttttaaatt attacttgaa gttttttatt taataaattt tttctactaa tgg 4253 <210> 163 <211> 3484 <212> DNA <213> Homo sapiens <400> 163 gtttgcgatc cccgcgtcca ggatggagca gctgaacgaa ctggagctgc tgatggagaa 60 gagtttttgg gaggaggcgg agctgccggc ggagctattt cagaagaaag tggtagcttc 120 ctttccaaga acagttctga gcacaggaat ggataaccgg tacctggtgt tggcagtcaa 180 tactgtacag aacaaagagg gaaactgtga aaagcgcctg gtcatcactg cttcacagtc 240 actagaaaat aaagaactat gcatccttag gaatgactgg tgttctgttc cagtagagcc 300 aggagatatc attcatttgg agggagactg cacatctgac acttggataa tagataaaga 360 ttttggatat ttgattctgt atccagacat gctgatttct ggcaccagca tagccagtag 420 tattcgatgt atgagaagag ctgtcctgag tgaaactttt aggagctctg atccagccac 480 acgccaaatg ctaattggta cggttctcca tgaggtgttt caaaaagcca taaataatag 540 ctttgcccca gaaaagctac aagaacttgc ttttcaaaca attcaagaaa taagacattt 600 gaaggaaatg taccgcttaa atctaagtca agatgaaata aaacaagaag tagaggacta 660 tcttccttcg ttttgtaaat gggcaggaga tttcatgcat aaaaacactt cgactgactt 720 ccctcagatg cagctctctc tgccaagtga taatagtaag gataattcaa catgtaacat 780 tgaagtcgtg aaaccaatgg atattgaaga aagcatttgg tcccctaggt ttggattgaa 840 aggcaaaata gatgttacag ttggtgtgaa aatacatcga gggtataaaa caaaatacaa 900 gataatgccg ctggaactta aaactggcaa agaatcaaat tctattgaac accgtagtca 960 ggttgttctg tacactctac taagccaaga gagaagagct gatccagagg ctggcttgct 1020 tctctacctc aagactggtc agatgtaccc tgtgcctgcc aaccatctag ataaaagaga 1080 attattaaag ctaagaaacc agatggcatt ctcattgttt caccgtatta gcaaatctgc 1140 tactagacag aagacacagc ttgcttcttt gccacaaata attgaggaag agaaaacttg 1200 taaatattgt tcacaaattg gcaattgtgc tctttatagc agagcagttg aacaacagat 1260 ggattgtagt tcagtcccaa ttgtgatgct gcccaaaata gaagaagaaa cccagcatct 1320 gaagcaaaca cacttagaat atttcagcct ttggtgtcta atgttaaccc tggagtcaca 1380 atcgaaggat aataaaaaga atcaccaaaa tatctggcta atgcctgctt cggaaatgga 1440 gaagagtggc agttgcattg gaaacctgat tagaatggaa catgtaaaga tagtttgtga 1500 tgggcaatat ttacataatt tccaatgtaa acatggtgcc atacctgtca caaatctaat 1560 ggcaggtgac agagttattg taagtggaga agaaaggtca ctgtttgctt tgtctagagg 1620 atatgtgaag gagattaaca tgacaacagt aacttgttta ttagacagaa acttgtcggt 1680 ccttccagaa tcaactttgt tcagattaga ccaagaagaa aaaaattgtg atatagatac 1740 cccattagga aatctttcca aattgatgga aaacacgttt gtcagcaaaa aacttcgaga 1800 tttaattatt gactttcgtg aacctcagtt tatatcctac cttagttctg ttcttccaca 1860 tgatgcaaag gatacagttg cctgcattct aaagggtttg aataagcctc agaggcaagc 1920 gatgaaaaag gtacttcttt caaaagacta cacactcatc gtgggtatgc ctgggacagg 1980 aaaaacaact acgatatgta ctctcgttcc agcgccagaa caagttgaaa aaggtggtgt 2040 gagcaatgta acagaagcca aactcatagt tttcctaacc tccatttttg ttaaggctgg 2100 atgcagtccc tctgatattg gtattattgc accgtacagg cagcaattaa agatcatcaa 2160 tgatttattg gcacgttcta ttgggatggt cgaagttaat acagtagaca aataccaagg 2220 aagggacaaa agtattgtcc tagtatcttt tgttagaagt aataaggatg gaactgttgg 2280 tgaactcttg aaagattggc gacgtcttaa tgttgctata accagagcca aacataaact 2340 gattcttctg gggtgtgtgc cctcactaaa ttgctatcct cctttggaga agctgcttaa 2400 tcatttaaac tcagaaaaat taatcattga tcttccatca agagaacatg aaagtctttg 2460 ccacatattg ggtgactttc aaagagaata aaacactatt tcccttgcct tttcatacta 2520 gggcagtatc tcctctagct agtgcccata cagaaaattc tatcaccata caaaatttaa 2580 tgcagtattt atgttttaaa gcacaggtgt accgaaaact gtgaaaagtc tgaatttatg 2640 ggttctatgc atgcattttt gcctaaccta gagaaagagt ttgataaatt tttaccagct 2700 ttgaagatgg attaactttt gactttgagc tttaaacttt taagtcagac atttcaggac 2760 taatttgatt ttgtagatat cattgtaaga actttatttg aaagactgaa taaagggatt 2820 tgatttgttt tcatcattta agcacagtct tgtgatgatg agaacataag tgtgattctt 2880 ttctgtattt tgaggtccct aatccaaagc ccattttgct aggatttttt ctgctatcag 2940 atgtgttttc actctaaacc tagtctttta tgacatgaat tgattacttc ctgttaattt 3000 tctatcctcc cttactatcc tccttttttg ttttcagtat tcagtatttc agtattctag 3060 agtagatttt gatataaaag aaaataattc ttacatcatc ttttgcaaca aattttgttt 3120 tctgaattga taataaattt aaaaagttga ttcctatttt cacatatgtt catatgcccc 3180 tatgtttggg ggtatcactc agttttccct tttttgtgta aagatgtttt gtaaaacaaa 3240 attgtctcaa agtgattata ttatatatat aaaaagtaac agattttaac aaaggttaaa 3300 agattcttgg ggtaacagat tcttctgggg cttggaaatc ttccatttct cttgagggtt 3360 ttttttaatg agtgttaaat atgttaaaat ttttatttct acctcatgtg tttttttaaa 3420 ttattacttg aagtttttta tttaataaat tttttctact aatggaaaaa aaaaaaaaaa 3480 aaaa 3484 <210> 164 <211> 2476 <212> DNA <213> Homo sapiens <400> 164 aaaaaattgt gatatagata ccccattagg aaatctttcc aaattgatgg aaaacacgtt 60 tgtcagcaaa aaacttcgag atttaattat tgactttcgt gaacctcagt ttatatccta 120 ccttagttct gttcttccac atgatgcaaa ggatacagtt gcctgcattc taaagggttt 180 gaataagcct cagaggcaag cgatgaaaaa ggtacttctt tcaaaagact acacactcat 240 cgtgggtatg cctgggacag gaaaaacaac tacgatatgt actctcgtaa gaattctcta 300 cgcctgtggt tttagcgttt tgttgaccag ctatacacac tctgctgttg acaatattct 360 tttgaagtta gccaagttta aaataggatt tttgcgtttg ggtcagattc agaaggttca 420 tccagctatc cagcaattta cagagcaaga aatttgcaga tcaaagtcca ttaaatcctt 480 agctcttcta gaagaactct acaatagtca acttatagtt gcaacaacat gtatgggaat 540 aaaccatcca atattttccc gtaaaatttt tgatttttgt attgtggatg aagcctctca 600 aattagccaa ccaatttgtc tgggccccct ttttttttca cggagatttg tgttagtggg 660 ggaccatcag cagcttcctc ccctggtgct aaaccgtgaa gcaagagctc ttggcatgag 720 tgaaagctta ttcaagaggc tggagcagaa taagagtgct gttgtacagt taaccgtgca 780 gtacagaatg aacagtaaaa ttatgtcctt aagtaataag ctgacctatg agggcaagct 840 ggagtgtgga tcagacaaag tggccaatgc agtgataaac ctacgtcact ttaaagatgt 900 gaagctggaa ctggaatttt atgctgacta ttctgataat ccttggttga tgggagtatt 960 tgaacccaac aatcctgttt gtttccttaa tacagacaag gttccagcgc cagaacaagt 1020 tgaaaaaggt ggtgtgagca atgtaacaga agccaaactc atagttttcc taacctccat 1080 ttttgttaag gctggatgca gtccctctga tattggtatt attgcaccgt acaggcagca 1140 attaaagatc atcaatgatt tattggcacg ttctattggg atggtcgaag ttaatacagt 1200 agacaaatac caaggaaggg acaaaagtat tgtcctagta tcttttgtta gaagtaataa 1260 ggatggaact gttggtgaac tcttgaaaga ttggcgacgt cttaatgttg ctataaccag 1320 agccaaacat aaactgattc ttctggggtg tgtgccctca ctaaattgct atcctccttt 1380 ggagaagctg cttaatcatt taaactcaga aaaattaatc attgatcttc catcaagaga 1440 acatgaaagt ctttgccaca tattgggtga ctttcaaaga gaataaaaca ctatttccct 1500 tgccttttca tactagggca gtatctcctc tagctagtgc ccatacagaa aattctatca 1560 ccatacaaaa tttaatgcag tatttatgtt ttaaagcaca ggtgtaccga aaactgtgaa 1620 aagtctgaat ttatgggttc tatgcatgca tttttgccta acctagagaa agagtttgat 1680 aaatttttac cagctttgaa gatggattaa cttttgactt tgagctttaa acttttaagt 1740 cagacatttc aggactaatt tgattttgta gatatcattg taagaacttt atttgaaaga 1800 ctgaataaag ggatttgatt tgttttcatc atttaagcac agtcttgtga tgatgagaac 1860 ataagtgtga ttcttttctg tattttgagg tccctaatcc aaagcccatt ttgctaggat 1920 tttttctgct atcagatgtg ttttcactct aaacctagtc ttttatgaca tgaattgatt 1980 acttcctgtt aattttctat cctcccttac tatcctcctt ttttgttttc agtattcagt 2040 atttcagtat tctagagtag attttgatat aaaagaaaat aattcttaca tcatcttttg 2100 caacaaattt tgttttctga attgataata aatttaaaaa gttgattcct attttcacat 2160 atgttcatat gcccctatgt ttgggggtat cactcagttt tccctttttt gtgtaaagat 2220 gttttgtaaa acaaaattgt ctcaaagtga ttatattata tatataaaaa gtaacagatt 2280 ttaacaaagg ttaaaagatt cttggggtaa cagattcttc tggggcttgg aaatcttcca 2340 tttctcttga gggttttttt ttaatgagtg ttaaatatgt taaaattttt atttctacct 2400 catgtgtttt tttaaattat tacttgaagt tttttattta ataaattttt tctactaatg 2460 gaaaaaaaaa aaaaaa 2476 <210> 165 <211> 2300 <212> DNA <213> Homo sapiens <400> 165 gtttgaataa gcctcagagg caagcgatga aaaaggtact tctttcaaaa gactacacac 60 tcatcgtggg tatgcctggg acaggaaaaa caactacgat atgtactctc gtaagaattc 120 tctacgcctg tggttttagc gttttgttga ccagctatac acactctgct gttgacaata 180 ttcttttgaa gttagccaag tttaaaatag gatttttgcg tttgggtcag attcagaagg 240 ttcatccagc tatccagcaa tttacagagc aagaaatttg cagatcaaag tccattaaat 300 ccttagctct tctagaagaa ctctacaata gtcaacttat agttgcaaca acatgtatgg 360 gaataaacca tccaatattt tcccgtaaaa tttttgattt ttgtattgtg gatgaagcct 420 ctcaaattag ccaaccaatt tgtctgggcc cccttttttt ttcacggaga tttgtgttag 480 tgggggacca tcagcagctt cctcccctgg tgctaaaccg tgaagcaaga gctcttggca 540 tgagtgaaag cttattcaag aggctggagc agaataagag tgctgttgta cagttaaccg 600 tgcagtacag aatgaacagt aaaattatgt ccttaagtaa taagctgacc tatgagggca 660 agctggagtg tggatcagac aaagtggcca atgcagtgat aaacctacgt cactttaaag 720 atgtgaagct ggaactggaa ttttatgctg actattctga taatccttgg ttgatgggag 780 tatttgaacc caacaatcct gtttgtttcc ttaatacaga caaggttcca gcgccagaac 840 aagttgaaaa aggtggtgtg agcaatgtaa cagaagccaa actcatagtt ttcctaacct 900 ccatttttgt taaggctgga tgcagtccct ctgatattgg tattattgca ccgtacaggc 960 agcaattaaa gatcatcaat gatttattgg cacgttctat tgggatggtc gaagttaata 1020 cagtagacaa ataccaagga agggacaaaa gtattgtcct agtatctttt gttagaagta 1080 ataaggatgg aactgttggt gaactcttga aagattggcg acgtcttaat gttgctataa 1140 ccagagccaa acataaactg attcttctgg ggtgtgtgcc ctcactaaat tgctatcctc 1200 ctttggagaa gctgcttaat catttaaact cagaaaaatt aatcattgat cttccatcaa 1260 gagaacatga aagtctttgc cacatattgg gtgactttca aagagaataa aacactattt 1320 cccttgcctt ttcatactag ggcagtatct cctctagcta gtgcccatac agaaaattct 1380 atcaccatac aaaatttatt gcagtattta tgttttaaag cacaggtgta ccgaaaactg 1440 tgaaaagtct gaatttatgg gttctatgca tgcatttttg cctaacctag agaaagagtt 1500 tgataaattt ttaccagctt tgaagatgga ttaacttttg actttgagct ttaaactttt 1560 aagtcagaca tttcaggact aatttgattt tgtagatatc attgtaagaa ctttatttga 1620 aagactgaat aaagggattt gatttgtttt catcatttaa gcacagtctt gtgatgatga 1680 gaacataagt gtgattcttt tctgtatttt gaggtcccta atccaaagcc cattttgcta 1740 ggattttttc tgctatcaga tgtgttttca ctctaaacct agtcttttat gacatgaatt 1800 gattacttcc tgttaatttt ctatcctccc ttactatcct ccttttttgt tttcagtatt 1860 cagtatttca gtattctaga gtagattttg atataaaaga aaataattct tacatcatct 1920 tttgcaacaa attttgtttt ctgaattgat aataaattta aaaagttgat tcctattttc 1980 acatatgttc atatgcccct atgtttgggg gtatcactca gttttccctt ttttgtgtaa 2040 agatgttttg taaaacaaaa ttgtctcaaa gtgattatat tatatatata aaaagtaaca 2100 gattttaaca aaggttaaaa gattcttggg gtaacagatt cttctggggc ttggaaatct 2160 tccatttctc ttgagggttt tttttaatga gtgttaaata tgttaaaatt tttatttcta 2220 cctcatgtgt ttttttaaat tattacttga agttttttat ttaataaatt ttttctacta 2280 atggaaaaaa aaaaaaaaaa 2300 <210> 166 <211> 1218 <212> DNA <213> Homo sapiens <400> 166 ccacgcgtcc gctctgctgt tgacaatatt cttttgaagt tagccaagtt taaaatagga 60 tttttgcgtt tgggtcagat tcagaaggtt catccagcta tccagcaatt tacagagcaa 120 gaaatttgca gatcaaagtc cattaaatcc ttagctcttc tagaagaact ctacaatagt 180 caacttatag ttgcaacaac atgtatggga ataaaccatc caatattttc ccgtaaaatt 240 tttgattttt gtattgtgga tgaagcctct caaattagcc aaccaatttg tctgggcccc 300 cttttttttt cacggagatt tgtgttagtg ggggaccatc agcagcttcc tcccctggtg 360 ctaaaccgtg aagcaagagc tcttggcatg agtgaaagct tattcaagag gctggagcag 420 aataagagtg ctgttgtaca gttaaccgtg cagtacagaa tgaacagtaa aattatgtcc 480 ttaagtaata agctgaccta tgagggcaag ctggagtgtg gatcagacaa agtggccaat 540 gcagtgataa acctacgtca ctttaaagat gtgaagctgg aactggaatt ttatgctgac 600 tattctgata atccttggtt gatgggagta tttgaaccca acaatcctgt ttgtttcctt 660 aatacagaca aggttccagc gccagaacaa gttgaaaaag gtggtgtgag caatgtaaca 720 gaagccaaac tcatagtttt cctaacctcc atttttgtta aggctggatg cagtccctct 780 gatattggta ttattgcacc gtacaggcag caattaaaga tcatcaatga tttattggca 840 cgttctattg ggatggtcga agttaataca gtagacaaat accaaggaag ggacaaaagt 900 attgtcctag tatcttttgt tagaagtaat aatgatggaa ctgttggtga actcttgaaa 960 gattggcgac gtcttaatgt tgctataacc agagccaaac ataaactgat tcttctgggg 1020 tgtgtgccct cactaaattg ctatcctcct ttggagaagc tgcttaatca tttaaactca 1080 gaaaaattaa tatccttttt cttctgtata tggtcacatt tgattgcact gttgtgagta 1140 tttatttgct tgtttaaatt aaagctctca ctatgttgct taaaaaaaaa aaaaaaaaaa 1200 aaaaaaaaaa aaaaaaaa 1218 <210> 167 <211> 1648 <212> DNA <213> Homo sapiens <400> 167 gttgcaacaa catgtatggg aataaaccat ccaatatttt cccgtaaaat ttttgatttt 60 tgtattgtgg atgaagcctc tcaaattagc caaccaattt gtctgggccc cctttttttt 120 tcacggagat ttgtgttagt gggggaccat cagcagcttc ctcccctggt gctaaaccgt 180 gaagcaagag ctcttggcat gagtgaaagc ttattcaaga ggctggagca gaataagagt 240 gctgttgtac agttaaccgt gcagtacaga atgaacagta aaattatgtc cttaagtaat 300 aagctgacct atgagggcaa gctggagtgt ggatcagaca aagtggccaa tgcagtgata 360 aacctacgtc actttaaaga tgtgaagctg gaactggaat tttatgctga ctattctgat 420 aatccttggt tgatgggagt atttgaaccc aacaatcctg tttgtttcct taatacagac 480 aaggttccag cgccagaaca agttgaaaaa ggtggtgtga gcaatgtaac agaagccaaa 540 ctcatagttt tcctaacctc catttttgtt aaggctggat gcagtccctc tgatattggt 600 attattgcac cgtacaggca gcaattaaag atcatcaatg atttattggc acgttctatt 660 gggatggtcg aagttaatac agtagacaaa taccaaggaa gggacaaaag tattgtccta 720 gtatcttttg ttagaagtaa taaggatgga actgttggtg aactcttgaa agattggcga 780 cgtcttaatg ttgctataac cagagccaaa cataaactga ttcttctggg gtgtgtgccc 840 tcactaaatt gctatcctcc tttggagaag ctgcttaatc atttaaactc agaaaaatta 900 atcattgatc ttccatcaag agaacatgaa agtctttgcc acatattggg tgactttcaa 960 agagaataaa acactatttc ccttgccttt tcatactagg gcagtatctc ctctagctag 1020 tgcccataca gaaaattcta tcaccataca aaatttaatg cagtatttat gttttaaagc 1080 acaggtgtac cgaaaactgt gaaaagtctg aatttatggg ttctatgcat gcatttttgc 1140 ctaacctaga gaaagagttt gataaatttt taccagcttt gaagatggat taacttttga 1200 ctttgagctt taaactttta agtcagacat ttcaggacta atttgatttt gtagatatca 1260 ttgtaagaac tttatttgaa agactgaata aagggatttg atttgttttc atcatttaag 1320 cacagtcttg tgatgatgag aacataagtg tgattctttt ctgtattttg aggtccctaa 1380 tccaaagccc attttgctag gattttttct gctatcagat gtgttttcac tctaaaccta 1440 gtcttttatg acatgaattg attacttcct gttaattttc tatcctccct tactatcctc 1500 cttttttgtt ttcagtattc agtatttcag tattctagag tagattttga tataaaagaa 1560 aataattctt acatcatctt ttgcaacaaa ttttgttttc tgaattgata ataaatttaa 1620 aaagttgatt cctaaaaaaa aaaaaaaa 1648 <210> 168 <211> 3083 <212> DNA <213> Homo sapiens <400> 168 cagaggcgcg cctggcggat ctgagtgtgt tgcccgggca gcggcgcgcg ggaccaacgc 60 aaggagcagc tgacagacga agaaaagtgc tggacaggaa gggagaattc tgacgccaac 120 atgcagcgaa gtatcatgtc atttttccac cccaagaaag agggtaaagc aaagaagcct 180 gagaaggagg catccaatag cagcagagag acggagcccc ctccaaaggc ggcactgaag 240 gagtggaatg gagtggtgtc cgagagtgac tctccggtga agaggccagg gaggaaggcg 300 gcccgggtcc tgggcagcga aggggaagag gaggatgaag cccttagccc tgctaaaggc 360 cagaagcctg ccctggactg ctcacaggtc tccccgcccc gtcctgccac atctcctgag 420 aacaatgctt ccctctctga cacctctccc atggacagtt ccccatcagg gattccgaag 480 cgtcgcacag ctcggaagca gctcccgaaa cggaccattc aggaagtcct ggaagagcag 540 agtgaggacg aggacagaga agccaagagg aagaaggagg aggaagaaga ggagaccccg 600 aaagaaagcc tcacagaggc tgaagtggca acagagaagg aaggagaaga cggggaccag 660 cccaccacgc ctcccaagcc cctaaagacc tccaaagcag agaccccgac ggaaagcgtt 720 tcagagcctg aggtggccac gaagcaggaa ctgcaggagg aggaagagca gaccaagcct 780 ccccgcagag ctcccaagac gctcagcagc ttcttcaccc cccggaagcc agcagtcaaa 840 aaagaagtga aggaagagga gccaggggct ccaggaaagg agggagctgc tgagggaccc 900 ctggatccat ctggttacaa tcctgccaag aacaactatc atcccgtgga agatgcctgc 960 tggaaaccgg gccagaaggt tccttacctg gctgtggccc ggacgtttga gaagatcgag 1020 gaggtgtctg ctcggctccg gatggtggag acgctgagca acttgctgcg ctccgtggtg 1080 gccctgtcgc ctccagacct cctccctgtc ctctacctca gcctcaacca ccttgggcca 1140 ccccagcagg gcctggagct tggcgtgggt gatggtgtcc ttctcaaggc agtggcccag 1200 gccacaggtc ggcagctgga gtccgtccgg gctgaggcag ccgagaaagg cgacgtgggg 1260 ctggtggccg agaacagccg cagcacccag aggctcatgc tgccaccacc tccgctcact 1320 gcctccgggg tcttcagcaa gttccgcgac atcgccaggc tcactggcag tgcttccaca 1380 gccaagaaga tagacatcat caaaggcctc tttgtggcct gccgccactc agaagcccgg 1440 ttcatcgcta ggtccctgag cggacggctg cgccttgggc tggcagagca gtcggtgctg 1500 gctgccctct cccaggcagt gagcctcacg cccccgggcc aagaattccc accagccatg 1560 gtggatgctg ggaagggcaa gacagcagag gccagaaaga cgtggctgga ggagcaaggc 1620 atgatcctga agcagacgtt ctgcgaggtt cccgacctgg accgaattat ccccgtgctg 1680 ctggagcacg gcctggaacg tctcccggag cactgcaagc tgagcccagg gattcccctg 1740 aaaccaatgt tggcccatcc cacccggggc atcagcgagg tcctgaaacg ctttgaggag 1800 gcagctttca cctgcgaata caaatatgac gggcagaggg cacagatcca cgccctggaa 1860 ggcggggagg tgaagatctt cagcaggaat caggaagaca acactgggaa gtacccggac 1920 atcatcagcc gcatccccaa gattaaactc ccatcggtca catccttcat cctggacacc 1980 gaagccgtgg cttgggaccg ggaaaagaag cagatccagc cattccaagt gctcaccacc 2040 cgcaaacgca aggaggtgga tgcgtctgag atccaggtgc aggtgtgttt gtacgccttc 2100 gacctcatct acctcaatgg agagtccctg gtacgtgagc ccctttcccg gcgccggcag 2160 ctgctccggg agaactttgt ggagacagag ggcgagtttg tcttcgccac ctccctggac 2220 accaaggaca tcgagcagat cgccgagttc ctggagcagt cagtgaaaga ctcctgcgag 2280 gggctgatgg tgaagaccct ggatgttgat gccacctacg agatcgccaa gagatcgcac 2340 aactggctca agctgaagaa ggactacctt gatggcgtgg gtgacaccct ggacctggtg 2400 gtgatcggcg cctacctggg ccgggggaag cgggccggcc ggtacggggg cttcctgctg 2460 gcctcctacg acgaggacag tgaggagctg caggccatat gcaagcttgg aactggcttc 2520 agtgatgagg agctggagga gcatcaccag agcctcaagg cgctggtgct gcccagccca 2580 cgcccttacg tgcggataga tggcgctgtg attcccgacc actggctgga ccccagcgct 2640 gtgtgggagg tgaagtgcgc tgacctctcc ctctctccca tctaccctgc tgcgcggggc 2700 ctggtggata gtgacaaggg catctccctt cgcttccctc ggtttattcg agtccgtgaa 2760 gacaagcagc cggagcaggc caccaccagt gctcaggtgg cctgtttgta ccggaagcaa 2820 agtcagattc agaaccaaca aggcgaggac tcaggctctg accctgaaga tacctactaa 2880 gccctcgccc tcctagggcc tgggtacagg gcatgagttg gacggacccc agggttatta 2940 ttgcctttgc tttttagcaa atctgctgtg gcaggctgtg gattttgaga gtcaggggag 3000 gggtgtgtgt gtgagggggt ggcttactcc ggagtctggg attcatcccg tcatttcttt 3060 caataaataa ttattggata gct 3083 <210> 169 <211> 3083 <212> DNA <213> Homo sapiens <400> 169 cagaggcgcg cctggcggat ctgagtgtgt tgcccgggca gcggcgcgcg ggaccaacgc 60 aaggagcagc tgacagacga agaaaagtgc tggacaggaa gggagaattc tgacgccaac 120 atgcagcgaa gtatcatgtc atttttccac cccaagaaag agggtaaagc aaagaagcct 180 gagaaggagg catccaatag cagcagagag acggagcccc ctccaaaggc ggcactgaag 240 gagtggaatg gagtggtgtc cgagagtgac tctccggtga agaggccagg gaggaaggcg 300 gcccgggtcc tgggcagcga aggggaagag gaggatgaag cccttagccc tgctaaaggc 360 cagaagcctg ccctggactg ctcacaggtc tccccgcccc gtcctgccac atctcctgag 420 aacaatgctt ccctctctga cacctctccc atggacagtt ccccatcagg gattccgaag 480 cgtcgcacag ctcggaagca gctcccgaaa cggaccattc aggaagtcct ggaagagcag 540 agtgaggacg aggacagaga agccaagagg aagaaggagg aggaagaaga ggagaccccg 600 aaagaaagcc tcacagaggc tgaagtggca acagagaagg aaggagaaga cggggaccag 660 cccaccacgc ctcccaagcc cctaaagacc tccaaagcag agaccccgac ggaaagcgtt 720 tcagagcctg aggtggccac gaagcaggaa ctgcaggagg aggaagagca gaccaagcct 780 ccccgcagag ctcccaagac gctcagcagc ttcttcaccc cccggaagcc agcagtcaaa 840 aaagaagtga aggaagagga gccaggggct ccaggaaagg agggagctgc tgagggaccc 900 ctggatccat ctggttacaa tcctgccaag aacaactatc atcccgtgga agatgcctgc 960 tggaaaccgg gccagaaggt tccttacctg gctgtggccc ggacgtttga gaagatcgag 1020 gaggtgtctg ctcggctccg gatggtggag acgctgagca acttgctgcg ctccgtggtg 1080 gccctgtcgc ctccagacct cctccctgtc ctctacctca gcctcaacca ccttgggcca 1140 ccccagcagg gcctggagct tggcgtgggt gatggtgtcc ttctcaaggc agtggcccag 1200 gccacaggtc ggcagctgga gtccgtccgg gctgaggcag ccgagaaagg cgacgtgggg 1260 ctggtggccg agaacagccg cagcacccag aggctcatgc tgccaccacc tccgctcact 1320 gcctccgggg tcttcagcaa gttccgcgac atcgccaggc tcactggcag tgcttccaca 1380 gccaagaaga tagacatcat caaaggcctc tttgtggcct gccgccactc agaagcccgg 1440 ttcatcgcta ggtccctgag cggacggctg cgccttgggc tggcagagca gtcggtgctg 1500 gctgccctct cccaggcagt gagcctcacg cccccgggcc aagaattccc accagccatg 1560 gtggatgctg ggaagggcaa gacagcagag gccagaaaga cgtggctgga ggagcaaggc 1620 atgatcctga agcagacgtt ctgcgaggtt cccgacctgg accgaattat ccccgtgctg 1680 ctggagcacg gcctggaacg tctcccggag cactgcaagc tgagcccagg gattcccctg 1740 aaaccaatgt tggcccatcc cacccggggc atcagcgagg tcctgaaacg ctttgaggag 1800 gcagctttca cctgcgaata caaatatgac gggcagaggg cacagatcca cgccctggaa 1860 ggcggggagg tgaagatctt cagcaggaat caggaagaca acactgggaa gtacccggac 1920 atcatcagcc gcatccccaa gattaaactc ccatcggtca catccttcat cctggacacc 1980 gaagccgtgg cttgggaccg ggaaaagaag cagatccagc cattccaagt gctcaccacc 2040 cgcaaacgca aggaggtgga tgcgtctgag atccaggtgc aggtgtgttt gtacgccttc 2100 gacctcatct acctcaatgg agagtccctg gtacgtgagc ccctttcccg gcgccggcag 2160 ctgctccggg agaactttgt ggagacagag ggcgagtttg tcttcgccac ctccctggac 2220 accaaggaca tcgagcagat cgccgagttc ctggagcagt cagtgaaaga ctcctgcgag 2280 gggctgatgg tgaagaccct ggatgttgat gccacctacg agatcgccaa gagatcgcac 2340 aactggctca agctgaagaa ggactacctt gatggcgtgg gtgacaccct ggacctggtg 2400 gtgatcggcg cctacctggg ccgggggaag cgggccggcc ggtacggggg cttcctgctg 2460 gcctcctacg acgaggacag tgaggagctg caggccatat gcaagcttgg aactggcttc 2520 agtgatgagg agctggagga gcatcaccag agcctcaagg cgctggtgct gcccagccca 2580 cgcccttacg tgcggataga tggcgctgtg attcccgacc actggctgga ccccagcgct 2640 gtgtgggagg tgaagtgcgc tgacctctcc ctctctccca tctaccctgc tgcgcggggc 2700 ctggtggata gtgacaaggg catctccctt cgcttccctc ggtttattcg agtccgtgaa 2760 gacaagcagc cggagcaggc caccaccagt gctcaggtgg cctgtttgta ccggaagcaa 2820 agtcagattc agaaccaaca aggcgaggac tcaggctctg accctgaaga tacctactaa 2880 gccctcgccc tcctagggcc tgggtacagg gcatgagttg gacggacccc agggttatta 2940 ttgcctttgc tttttagcaa atctgctgtg gcaggctgtg gattttgaga gtcaggggag 3000 gggtgtgtgt gtgagggggt ggcttactcc ggagtctggg attcatcccg tcatttcttt 3060 caataaataa ttattggata gct 3083 <210> 170 <211> 3443 <212> DNA <213> Homo sapiens <400> 170 agtcaggggt cacggcggcg taggctgtgg cgggaaacgc tgtttgaagc gggatggatg 60 gcaagcggcg gccaggccca gggcccgggg tgcccccaaa gcgggcccgt gggggcctct 120 gggatgatga tgatgcacct tggccatccc aattcgagga ggacctggca ctgatggagg 180 agatggaggc agaacacagg ctgcaggagc aggaggagga ggagctgcag tcagtcctgg 240 agggggttgc agacgggcag gtcccaccat cagccataga tcctcgctgg cttcggccca 300 caccaccagc gctggacccc cagacagagc ccctcatctt ccaacagttg gagattgacc 360 attatgtggg cccagcgcag cctgtgcctg gggggccccc accatcccgc ggctccgtgc 420 ctgtgctccg cgccttcggg gtcaccgatg aggggttctc tgtctgctgc cacatccacg 480 gcttcgctcc ctacttctac accccagcgc cccctggttt cgggcccgag cacatgggtg 540 acctgcaacg ggagctgaac ttggccatca gccgggacag tcgcgggggg agggagctga 600 ctgggccggc cgtgctggct gtggaactgt gctcccgaga gagcatgttt gggtaccacg 660 ggcacggccc ctccccgttc ctgcgcatca ccgtggcgct gccgcgcctc gtggccccgg 720 cccgccgtct cctggaacag ggcatccgtg tggcaggcct gggcacgccc agcttcgcgc 780 cctacgaggc caacgtcgac tttgagatcc ggttcatggt ggacacggac atcgtcggct 840 gcaactggct ggagctccca gctgggaaat acgccctgag gctgaaggag aaggctacgc 900 agtgccagct ggaggcggac gtgctgtggt ctgacgtggt cagtcaccca ccggaagggc 960 catggcagcg cattgcgccc ttgcgcgtgc tcagcttcga tatcgagtgc gccggccgca 1020 aaggcatctt ccctgagcct gagcgggacc ctgtcatcca gatctgctcg ctgggcctgc 1080 gctgggggga gccggagccc ttcctacgcc tggcgctcac cctgcggccc tgtgccccca 1140 tcctgggtgc caaggtgcag agctacgaga aggaggagga cctgctgcag gcctggtcca 1200 ccttcatccg tatcatggac cccgacgtga tcaccggtta caacatccag aacttcgacc 1260 ttccgtacct catctctcgg gcccagaccc tcaaggtaca aacattccct ttcctgggcc 1320 gtgtggccgg cctttgctcc aacatccggg actcttcatt ccagtccaag cagacgggcc 1380 ggcgggacac caaggttgtc agcatggtgg gccgcgtgca gatggacatg ctgcaggtgc 1440 tgctgcggga gtacaagctc cgctcccaca cgctcaatgc cgtgagcttc cacttcctgg 1500 gcgagcagaa ggaggacgtg cagcacagca tcatcaccga cctgcagaat gggaacgacc 1560 agacccgccg ccgcctggct gtgtactgcc tgaaggatgc ctacctgcca ctgcggctgc 1620 tggagcggct catggtgctg gtgaacgccg tggagatggc gagggtcact ggcgtgcccc 1680 tcagctacct gctcagtcgt ggccagcagg tcaaagtcgt atcccagctg ttgcggcagg 1740 ccatgcacga ggggctgctg atgcccgtgg tgaagtcaga gggcggcgag gactacacgg 1800 gagccactgt catcgagccc ctcaaagggt actacgacgt ccccatcgcc accctggact 1860 tctcctcgct gtacccgtcc atcatgatgg cccacaacct gtgttacacc acgctccttc 1920 ggcccgggac tgcacagaaa ctgggcctga ctgaggatca gttcatcagg acccccaccg 1980 gggacgagtt tgtgaagacc tcagtgcgga aggggctgct gccccagatc ctggagaacc 2040 tgctcagtgc ccggaagagg gccaaggccg agctggccaa ggagacagac cccctccggc 2100 gccaggtcct ggatggacgg cagctggcgc tgaaggtgag cgccaactcc gtatacggct 2160 tcactggcgc ccaggtgggc aagttgccgt gcctggagat ctcacagagc gtcacggggt 2220 tcggacgtca gatgatcgag aaaaccaagc agctggtgga gtctaagtac acagtggaga 2280 atggctacag caccagtgcc aaggtggtgt atggtgacac tgactccgtc atgtgccgat 2340 tcggcgtgtc ctcggtggct gaggcgatgg ccctggggcg ggaggccgcg gactgggtgt 2400 caggtcactt cccgtcgccc atccggctgg agtttgagaa ggtctacttc ccatacctgc 2460 ttatcagcaa gaagcgctac gcgggcctgc tcttctcctc ccggcccgac gcccacgacc 2520 gcatggactg caagggcctg gaggccgtgc gcagggacaa ctgccccctc gtggccaacc 2580 tggtcactgc ctcactgcgc cgcctgctca tcgaccgaga ccctgagggc gcggtggctc 2640 acgcacagga cgtcatctcg gacctgctgt gcaaccgcat cgatatctcc cagctggtca 2700 tcaccaagga gctgacccgc gcggcctccg actatgccgg caagcaggcc cacgtggagc 2760 tggccgagag gatgaggaag cgggaccccg ggagtgcgcc cagcctgggc gaccgcgtcc 2820 cctacgtgat catcagtgcc gccaagggtg tggccgccta catgaagtcg gaggacccgc 2880 tgttcgtgct ggagcacagc ctgcccattg acacgcagta ctacctggag cagcagctgg 2940 ccaagcccct cctgcgcatc ttcgagccca tcctgggcga gggccgtgcc gaggctgtgc 3000 tactgcgggg ggaccacacg cgctgcaaga cggtgctcac gggcaaggtg ggcggcctcc 3060 tggccttcgc caaacgccgc aactgctgca ttggctgccg cacagtgctc agccaccagg 3120 gagccgtgtg tgagttctgc cagccccggg agtctgagct gtatcagaag gaggtatccc 3180 atctgaatgc cctggaggag cgcttctcgc gcctctggac gcagtgccag cgctgccagg 3240 gcagcctgca cgaggacgtc atctgcacca gccgggactg ccccatcttc tacatgcgca 3300 agaaggtgcg gaaggacctg gaagaccagg agcagctcct gcggcgcttc ggaccccctg 3360 gacctgaggc ctggtgacct tgcaagcatc ccatggggcg ggggcgggac cagggagaat 3420 taataaagtt ctggactttt gct 3443 <210> 171 <211> 3443 <212> DNA <213> Homo sapiens <400> 171 agtcaggggt cacggcggcg taggctgtgg cgggaaacgc tgtttgaagc gggatggatg 60 gcaagcggcg gccaggccca gggcccgggg tgcccccaaa gcgggcccgt gggggcctct 120 gggatgatga tgatgcacct tggccatccc aattcgagga ggacctggca ctgatggagg 180 agatggaggc agaacacagg ctgcaggagc aggaggagga ggagctgcag tcagtcctgg 240 agggggttgc agacgggcag gtcccaccat cagccataga tcctcgctgg cttcggccca 300 caccaccagc gctggacccc cagacagagc ccctcatctt ccaacagttg gagattgacc 360 attatgtggg cccagcgcag cctgtgcctg gggggccccc accatcccgc ggctccgtgc 420 ctgtgctccg cgccttcggg gtcaccgatg aggggttctc tgtctgctgc cacatccacg 480 gcttcgctcc ctacttctac accccagcgc cccctggttt cgggcccgag cacatgggtg 540 acctgcaacg ggagctgaac ttggccatca gccgggacag tcgcgggggg agggagctga 600 ctgggccggc cgtgctggct gtggaactgt gctcccgaga gagcatgttt gggtaccacg 660 ggcacggccc ctccccgttc ctgcgcatca ccgtggcgct gccgcgcctc gtggccccgg 720 cccgccgtct cctggaacag ggcatccgtg tggcaggcct gggcacgccc agcttcgcgc 780 cctacgaggc caacgtcgac tttgagatcc ggttcatggt ggacacggac atcgtcggct 840 gcaactggct ggagctccca gctgggaaat acgccctgag gctgaaggag aaggctacgc 900 agtgccagct ggaggcggac gtgctgtggt ctgacgtggt cagtcaccca ccggaagggc 960 catggcagcg cattgcgccc ttgcgcgtgc tcagcttcga tatcgagtgc gccggccgca 1020 aaggcatctt ccctgagcct gagcgggacc ctgtcatcca gatctgctcg ctgggcctgc 1080 gctgggggga gccggagccc ttcctacgcc tggcgctcac cctgcggccc tgtgccccca 1140 tcctgggtgc caaggtgcag agctacgaga aggaggagga cctgctgcag gcctggtcca 1200 ccttcatccg tatcatggac cccgacgtga tcaccggtta caacatccag aacttcgacc 1260 ttccgtacct catctctcgg gcccagaccc tcaaggtaca aacattccct ttcctgggcc 1320 gtgtggccgg cctttgctcc aacatccggg actcttcatt ccagtccaag cagacgggcc 1380 ggcgggacac caaggttgtc agcatggtgg gccgcgtgca gatggacatg ctgcaggtgc 1440 tgctgcggga gtacaagctc cgctcccaca cgctcaatgc cgtgagcttc cacttcctgg 1500 gcgagcagaa ggaggacgtg cagcacagca tcatcaccga cctgcagaat gggaacgacc 1560 agacccgccg ccgcctggct gtgtactgcc tgaaggatgc ctacctgcca ctgcggctgc 1620 tggagcggct catggtgctg gtgaacgccg tggagatggc gagggtcact ggcgtgcccc 1680 tcagctacct gctcagtcgt ggccagcagg tcaaagtcgt atcccagctg ttgcggcagg 1740 ccatgcacga ggggctgctg atgcccgtgg tgaagtcaga gggcggcgag gactacacgg 1800 gagccactgt catcgagccc ctcaaagggt actacgacgt ccccatcgcc accctggact 1860 tctcctcgct gtacccgtcc atcatgatgg cccacaacct gtgttacacc acgctccttc 1920 ggcccgggac tgcacagaaa ctgggcctga ctgaggatca gttcatcagg acccccaccg 1980 gggacgagtt tgtgaagacc tcagtgcgga aggggctgct gccccagatc ctggagaacc 2040 tgctcagtgc ccggaagagg gccaaggccg agctggccaa ggagacagac cccctccggc 2100 gccaggtcct ggatggacgg cagctggcgc tgaaggtgag cgccaactcc gtatacggct 2160 tcactggcgc ccaggtgggc aagttgccgt gcctggagat ctcacagagc gtcacggggt 2220 tcggacgtca gatgatcgag aaaaccaagc agctggtgga gtctaagtac acagtggaga 2280 atggctacag caccagtgcc aaggtggtgt atggtgacac tgactccgtc atgtgccgat 2340 tcggcgtgtc ctcggtggct gaggcgatgg ccctggggcg ggaggccgcg gactgggtgt 2400 caggtcactt cccgtcgccc atccggctgg agtttgagaa ggtctacttc ccatacctgc 2460 ttatcagcaa gaagcgctac gcgggcctgc tcttctcctc ccggcccgac gcccacgacc 2520 gcatggactg caagggcctg gaggccgtgc gcagggacaa ctgccccctc gtggccaacc 2580 tggtcactgc ctcactgcgc cgcctgctca tcgaccgaga ccctgagggc gcggtggctc 2640 acgcacagga cgtcatctcg gacctgctgt gcaaccgcat cgatatctcc cagctggtca 2700 tcaccaagga gctgacccgc gcggcctccg actatgccgg caagcaggcc cacgtggagc 2760 tggccgagag gatgaggaag cgggaccccg ggagtgcgcc cagcctgggc gaccgcgtcc 2820 cctacgtgat catcagtgcc gccaagggtg tggccgccta catgaagtcg gaggacccgc 2880 tgttcgtgct ggagcacagc ctgcccattg acacgcagta ctacctggag cagcagctgg 2940 ccaagcccct cctgcgcatc ttcgagccca tcctgggcga gggccgtgcc gaggctgtgc 3000 tactgcgggg ggaccacacg cgctgcaaga cggtgctcac gggcaaggtg ggcggcctcc 3060 tggccttcgc caaacgccgc aactgctgca ttggctgccg cacagtgctc agccaccagg 3120 gagccgtgtg tgagttctgc cagccccggg agtctgagct gtatcagaag gaggtatccc 3180 atctgaatgc cctggaggag cgcttctcgc gcctctggac gcagtgccag cgctgccagg 3240 gcagcctgca cgaggacgtc atctgcacca gccgggactg ccccatcttc tacatgcgca 3300 agaaggtgcg gaaggacctg gaagaccagg agcagctcct gcggcgcttc ggaccccctg 3360 gacctgaggc ctggtgacct tgcaagcatc ccatggggcg ggggcgggac cagggagaat 3420 taataaagtt ctggactttt gct 3443 <210> 172 <211> 3460 <212> DNA <213> Homo sapiens <400> 172 cggcggcgta ggctgtggcg ggaaacgctg tttgaagcgg caggatggat ggcaagcggc 60 ggccaggccc agggcccggg gtgcccccaa agcgggcccg tgggggcctc tgggatgatg 120 atgatgcacc tcggccatcc caattcgagg aggacctggc actgatggag gagatggagg 180 cagaacacag gctgcaggag caggaggagg aggagctgca gtcagtcctg gagggggttg 240 cagacgggca ggtcccacca tcagccatag atcctcgctg gcttcggccc acaccaccag 300 cgctggaccc ccagacagag cccctcatct tccaacagtt ggagattgac cattatgtgg 360 gcccagcaca gcctgtgcct ggggggcccc caccatccca cggctccgtg cctgtgctcc 420 gcgccttcgg ggtcaccgat gaggggttct ctgtctgctg ccacatccac ggcttcgctc 480 cctacttcta caccccagcg ccccctggtt tcgggcccga gcacatgggt gacctgcaac 540 gggagctgaa cttggccatc agccgggaca gtcgcggggg gagggagctg actgggccgg 600 ccgtgctggc tgtggaactg tgctcccgag agagcatgtt tgggtaccac gggcacggcc 660 cctccccgtt cctgcgcatc accgtggcgc tgccgcgcct cgtggccccg gcccgccgtc 720 tcctggaaca gggcatccgt gtggcaggcc tgggcacgcc cagcttcgcg ccctacgagg 780 ccaacgtcga ctttgagatc cggttcatgg tggacacgga catcgtcggc tgcaactggc 840 tggagctccc agctgggaaa tacgccctga ggctgaagga gaaggctacg cagtgccagc 900 tggaggcgga cgtgctgtgg tctgacgtgg tcagtcaccc accggaaggg ccatggcagc 960 gcattgcgcc cttgcgcgtg ctcagcttcg atatcgagtg cgccggccgc aaaggcatct 1020 tccctgagcc tgagcgggac cctgtcatcc agatctgctc gctgggcctg cgctgggggg 1080 agccggagcc cttcctacgc ctggcgctca ccctgcggcc ctgtgccccc atcctgggtg 1140 ccaaggtgca gagctacgag aaggaggagg acctgctgca ggcctggtcc accttcatcc 1200 gtatcatgga ccccgacgtg atcaccggtt acaacatcca gaacttcgac cttccgtacc 1260 tcatctctcg ggcccagacc ctcaaggtac aaacattccc tttcctgggc cgtgtggccg 1320 gcctttgctc caacatccgg gactcttcat tccagtccaa gcagacgggc cggcgggaca 1380 ccaaggttgt cagcatggtg ggccgcgtgc agatggacat gctgcaggtg ctgctgcggg 1440 agtacaagct ccgctcctac acgctcaatg ccgtgagctt ccacttcctg ggcgagcaga 1500 aggaggacgt gcagcacagc atcatcaccg acctgcagaa tgggaacgac cagacccgcc 1560 gccgcctggc tgtgtactgc ctgaaggatg cctacctgcc actgcggctg ctggagcggc 1620 tcatggtgct ggtgaacgcc gtggagatgg cgagggtcac tggcgtgccc ctcagctacc 1680 tgctcagtcg tggccagcag gtcaaggtcg tatcccagct gttgcggcag gccatgcacg 1740 aggggctgct gatgcccgtg gtgaagtcag agggcggcga ggactacacg ggagccactg 1800 tcatcgagcc cctcaaaggg tactacgacg tccccatcgc caccctggac ttctcctcgc 1860 tgtacccgtc catcatgatg gcccacaacc tgtgttacac cacgctcctt cggcccggga 1920 ctgcacagaa actgggcctg actgaggatc agttcatcag gacccccacc ggggacgagt 1980 ttgtgaagac ctcagtgcgg aaggggctgc tgccccagat cctggagaac ctgctcagtg 2040 cccggaagag ggccaaggcc gagctggcca aggagacaga ccccctccgg cgccaggtcc 2100 tggatggacg gcagctggcg ctgaaggtga gcgccaactc cgtatacggc ttcactggcg 2160 cccaggtggg caagttgccg tgcctggaga tctcacagag cgtcacgggg ttcggacgtc 2220 agatgatcga gaaaaccaag cagctggtgg agtctaagta cacagtggag aatggctaca 2280 gcaccagtgc caaggtggtg tatggtgaca ctgactccgt catgtgccga ttcggcgtgt 2340 cctcggtggc tgaggcgatg gccctggggc gggaggccgc ggactgggtg tcaggtcact 2400 tcccgtcgcc catccggctg gagtttgaga aggtctactt cccatacctg cttatcagca 2460 agaagcgcta cgcgggcctg ctcttctcct cccggcccga cgcccacgac cgcatggact 2520 gcaagggcct ggaggccgtg cgcagggaca actgccccct cgtggccaac ctggtcactg 2580 cctcactgcg ccgcctgctc atcgaccgag accctgaggg cgcggtggct cacgcacagg 2640 acgtcatctc ggacctgctg tgcaaccgca tcgatatctc ccagctggtc atcaccaagg 2700 agctgacccg cgcggcctcc gactatgccg gcaagcaggc ccacgtggag ctggccgaga 2760 ggatgaggaa gcgggacccc gggagtgcgc ccagcctggg cgaccgcgtc ccctacgtga 2820 tcatcagtgc cgccaagggt gtggccgcct acatgaagtc ggaggacccg ctgttcgtgc 2880 tggagcacag cctgcccatt gacacgcagt actacctgga gcagcagctg gccaagcccc 2940 tcctgcgcat cttcgagccc atcctgggcg agggccgtgc cgaggctgtg ctactgcggg 3000 gggaccacac gcgctgcaag acggtgctca cgggcaaggt gggcggcctc ctggccttcg 3060 ccaaacgccg caactgctgc attggctgcc gcacagtgct cagccaccag ggagccgtgt 3120 gtgagttctg ccagccccgg gagtctgagc tgtatcagaa ggaggtatcc catctgaatg 3180 ccctggagga gcgcttctcg cgcctctgga cgcagtgcca gcgctgccag ggcagcctgc 3240 acgaggacgt catctgcacc agccgggact gccccatctt ctacatgcgc aagaaggtgc 3300 ggaaggacct ggaagaccag gagcagctcc tgcggcgctt cggaccccct ggacctgagg 3360 cctggtgacc ttgcaagcat cccatggggc gggggcggga ccagggagaa ttaataaagt 3420 tctggacttt tgctacaaaa aaaaaaaaaa aaaaaaaaaa 3460 <210> 173 <211> 3435 <212> DNA <213> Homo sapiens <400> 173 acggcggcgt aggctgtggc gggaaacgct gtttgaagcg ggatggatgg caagcggcgg 60 ccaggcccag ggcccggggt gcccccaaag cgggcccgtg ggggcctctg ggatgatgat 120 gatgcacctc ggccatccca attcgaggag gacctggcac tgatggagga gatggaggca 180 gaacacaggc tgcaggagca ggaggaggag gagctgcagt cagtcctgga gggggttgca 240 gacgggcagg tcccaccatc agccatagat cctcgctggc ttcggcccac accaccagcg 300 ctggaccccc agacagagcc cctcatcttc caacagttgg agattgacca ttatgtgggc 360 ccagcgcagc ctgtgcctgg ggggccccca ccatcccacg gctccgtgcc tgtgctccgc 420 gccttcgggg tcaccgatga ggggttctct gtctgctgcc acatccacgg cttcgctccc 480 tacttctaca ccccagcgcc ccctggtttc gggcccgagc acatgggtga cctgcaacgg 540 gagctgaact tggccatcaa ccgggacagt cgcgggggga gggagctgac tgggccggcc 600 gtgctggctg tggaactgtg ctcccgagag agcatgtttg ggtaccacgg gcacggcccc 660 tccccgttcc tgcgcatcac cgtggcgctg ccgcgcctcg tggccccggc ccgccgtctc 720 ctggaacagg gcatccgtgt ggcaggcctg ggcacgccca gcttcgcgcc ctacgaggcc 780 aacgtcgact ttgagatccg gttcatggtg gacacggaca tcgtcggctg caactggctg 840 gagctcccag ccgggaaata cgccctgagg ctgaaggaga aggctacgca gtgccagctg 900 gaggcggacg tgctgtggtc tgacgtggtc agtcacccac cggaagggcc atggcagcgc 960 attgcgccct tgcgcgtgct cagcttcgat atcgagtgcg ccggccgcaa aggcatcttc 1020 cctgagcctg agcgggaccc tgtcatccag atctgctcgc tgggcctgcg ctggggggag 1080 ccggagccct tcctacgcct ggcgctcacc ctgcggccct gtgcccccat cctgggtgcc 1140 aaggtgcaga gctacgagaa ggaggaggac ctgctgcagg cctggtccac cttcatccgt 1200 atcatggacc ccgatgtgat caccggttac aacatccaga acttcgacct tccgtacctc 1260 atctctcggg cccagaccct caaggtacaa acattccctt tcctgggccg tgtggccggc 1320 ctttgctcca acatccggga ctcttcattc cagtccaagc agacgggccg gcgggacacc 1380 aaggttgtca gcatggtggg ccgcgtgcag atggacatgc tgcaggtgct gctgcgggag 1440 tacaagctcc gctcctacac gctcaatgcc gtgagcttcc acttcctggg cgagcagaag 1500 gaggacgtgc agcacagcat catcaccgac ctgcagaatg ggaacgacca gacccgccgc 1560 cgcctggctg tgtactgcct aaaggatgct tacctgccac tgcggctgct ggagcggctc 1620 atggtgctgg tgaacgccgt ggagatggcg agggtcactg gcgtgcccct cagctacctg 1680 ctcagtcgtg gccagcaggt caaggtcgta tcccagctgt tgcggcaggc catgcacgag 1740 gggctgctga tgcccgtggt gaagtcagag ggcggcgagg actacacggg agccactgtc 1800 attgagcccc tcaaagggta ctacgacgtc cccatcgcca ccctggactt ctcctcgctg 1860 tacccgtcca tcatgatggc ccacaacctg tgttacacca cactccttcg gcccgggact 1920 gcacagaaac tgggcctgac tgaggatcag ttcatcagga cccccaccgg ggacgagttt 1980 gtgaagacct cagtgcgtaa ggggctgctg ccccagatcc tggagaacct gctcagtgcc 2040 cggaagaggg ccaaggccga gctggccaag gagacagacc ccctccggcg ccaggtcctg 2100 gatggacggc agctggcgct gaaggtgagc gccaactccg tatacggctt cactggcgcc 2160 caggtgggca agttgccgtg cctggagatc tcacagagcg tcacggggtt cggacgtcag 2220 atgatcgaga aaaccaagca gctggtggag tctaagtaca cagtggagaa tggctacagc 2280 accagcgcca aggtggtgta tggtgacact gactccgtca tgtgccgatt cggcgtgtcc 2340 tcggtggctg aggcgatggc cctgggcggg gaggccgcgg actgggtgtc aggtcacttc 2400 ccgtcgccca tccggctgga gtttgagaag gtctacttcc catacctgct tatcagcaag 2460 aagcgctacg cgggcctgct cttctcctcc cggcccgacg cccacgaccg catggactgc 2520 aagggcctgg aggcggtgcg cagggacaac tgccccctcg tggccaacct ggtcactgcc 2580 tcactgcgcc gcctgctcat cgaccgagac cctgagggcg cggtggctca cgcacaggac 2640 gtcatctcgg acctgctgtg caaccgcatc gatatctccc agctggtcat caccaaggag 2700 ctgacccgcg cggcctccga ctatgccggc aagcaggccc acgtggagct ggccgagagg 2760 atgaggaagc gggaccccgg gagtgcgccc agcctgggcg accgcgtccc ctacgtgatc 2820 atcagtgccg ccaagggtgt ggccgcctac atgaagtcgg aggacccgct gttcgtgctg 2880 gagcacagcc tgcccattga cacgcagtac tacctggagc agcagctggc caagcccctc 2940 ctgcgcatct tcgagcccat cctgggcgag ggccgtgccg aggctgtgct actgcggggg 3000 gaccacacgc gctgcaagac ggtgctcacg ggcaaggtgg gcggcctcct ggccttcgcc 3060 aaacgccgca actgctgcat tggctgccgc acagtgctca gccaccaggg agccgtgtgt 3120 gagttctgcc agccccggga gtctgagctg tatcagaagg aggtatccca tctgaatgcc 3180 ctggaggagc gcttctcgcg cctctggacg cagtgccagc gctgccaggg cagcctgcac 3240 gaggacgtca tctgcaccag ccgggactgc cccatcttct acatgcgcaa gaaggtgcgg 3300 aaggacctgg aagaccagga gcagctcctg cggcgcttcg gaccccctgg acctgaggcc 3360 tggtgacctt gcaagcatcc catggggcgg gggcgggacc agggagaatt aataaagttc 3420 tggacttttg ctaca 3435 <210> 174 <211> 6912 <212> DNA <213> Homo sapiens <400> 174 cgccaaattt ctcccctgaa gcagaggtgg tagccaacgg ctccatgtct ctgaggagcg 60 gcgggcggcg gcgcgcggac ccaggcgcgg atggcgaggc cagcagggat gatggcgcca 120 cttcctcagt ttcggcactc aagcgcctgg aacggagtca gtggacggat aagatggatt 180 tgcggtttgg ttttgagcgg ctgaaggagc ctggtgagaa gacaggctgg ctcattaaca 240 tgcatcctac cgagatttta gatgaagata agcgcttagg cagtgcagtg gattactact 300 ttattcaaga tgacggaagc agatttaagg tggctttgcc ctataaaccg tatttctaca 360 ttgcgaccag aaagggttgt gagcgagaag tttcatcttt tctctccaag aagtttcagg 420 gcaaaattgc aaaagtggag actgtcccca aagaggatct ggacttgcca aatcacttgg 480 tgggtttgaa gcgaaattac atcaggctgt ccttccacac tgtggaggat cttgtcaaag 540 tgaggaagga gatctcccct gccgtgaaga agaacaggga gcaggatcac gccagcgacg 600 cgtacacagc tctgctttcc agtgttctgc agaggggcgg tgtcattact gatgaagagg 660 aaacctctaa gaagatagct gaccagttgg acaacattgt ggacatgcgc gagtacgatg 720 ttccctacca catccgcctc tccattgacc tgaagatcca cgtggctcat tggtacaatg 780 tcagataccg aggaaatgct tttccggtag aaatcacccg ccgagatgac cttgttgaac 840 gacctgaccc tgtggttttg gcatttgaca ttgagacgac caaactgccc ctcaagtttc 900 ctgatgctga gacagaccag attatgatga tttcctacat gatcgatggc cagggctacc 960 tcatcaccaa cagggagatt gtttcagaag atattgaaga ttttgagttc acccccaagc 1020 cagaatatga aggccccttt tgtgtcttca atgaacccga tgaggctcat ctgatccaaa 1080 ggtggtttga acacgtccag gagaccaaac ccaccatcat ggtcacctac aacggggact 1140 tttttgactg gccatttgtg gaggcccggg cagcagtcca cggtctgagc atgcagcagg 1200 agataggctt ccagaaggac agccaggggg agtacaaggc gccccagtgc atccacatgg 1260 actgcctcag gtgggtgaag agggacagtt accttcctgt gggcagtcat aatctcaagg 1320 cggccgccaa ggccaagcta ggctatgatc ccgtggagct agacccggag gacatgtgcc 1380 ggatggccac ggagcagccc cagactctgg ccacgtattc tgtgtcagat gctgtcgcca 1440 cttactacct gtacatgaag tacgtccacc cattcatctt tgctctgtgc accattattc 1500 ccatggagcc cgacgaggtg ctgcggaagg gctctggcac tctgtgtgag gccttgctga 1560 tggtgcaggc cttccacgcc aacatcatct tccccaacaa gcaagagcag gagttcaata 1620 agctgacgga cgacggacac gtgctggact ctgagaccta cgtcgggggc cacgtggagg 1680 ccctcgagtc tggggttttc cgcagcgata tcccttgccg gtttaggatg aatcctgccg 1740 cctttgactt cctgctgcag cgggttgaga agaccttgcg ccacgccctt gaggaagagg 1800 agaaagtgcc tgtggagcaa gtcaccaact ttgaagaggt gtgtgatgag attaagagca 1860 agcttgcctc cctgaaggac gttcccagcc gcatcgagtg tccactcatc taccacctgg 1920 acgtgggggc catgtacccc aacatcatcc tgaccaaccg cctgcagccc tctgccatgg 1980 tggacgaagc cacctgtgct gcctgtgact tcaataagcc tggagcaaac tgccagcgga 2040 agatggcctg gcagtggagg ggcgagttca tgccagccag tcgcagcgaa taccatcgga 2100 tccagcacca gctggagtca gagaagttcc cccccttgtt cccagagggg ccagctcggg 2160 cctttcatga actgtcccgc gaggaacagg cgaaatacga gaagagaagg ctggcggatt 2220 actgccggaa agcctacaag aagatccaca tcaccaaggt ggaagagcgt ctcaccacca 2280 tctgccagcg ggaaaactcc ttctacgtgg acaccgtgcg tgccttccgg gacaggcgtt 2340 acgagttcaa agggctccac aaggtgtgga aaaagaagct ctcggcggcc gtggaggtgg 2400 gcgacgcggc tgaggtgaag cgctgcaaga acatggaggt gctgtatgac tcgctgcagc 2460 tggcccacaa gtgcatcctg aactccttct atggctatgt catgcgcaag ggggctcgct 2520 ggtactccat ggagatggct ggcatcgtct gcttcacagg ggccaacatc atcacccagg 2580 cacgggagct gatcgagcag attgggaggc ccttagagct ggacacagat ggtatatggt 2640 gcgtcctgcc caacagcttc ccagaaaatt ttgtcttcaa gacgaccaat gtgaagaagc 2700 ccaaagtgac catctcctac ccaggcgcca tgttgaacat catggtcaag gaaggcttca 2760 ccaatgacca gtaccaggag ctggctgagc cgtcctcact cacctacgtc acccgctcag 2820 agaacagcat cttttttgag gttgatgggc cctaccttgc catgattctt ccagcctcca 2880 aggaagaagg caagaaattg aagaagaggt atgctgtgtt caatgaagac ggttctctgg 2940 ctgagctcaa gggctttgag gtcaaacgcc gcggggaact gcagctgatt aagatcttcc 3000 aatcctcggt gtttgaggcc ttcctcaagg gcagcacgct ggaagaggtg tatggctctg 3060 tagccaaggt ggctgactac tggctggacg tgctgtacag caaggcagcc aacatgcctg 3120 actctgagct attcgagctc atctctgaga accgttccat gtctcggaag ctggaagatt 3180 acggggagca gaagtctaca tccatcagca cagcaaagcg cctggccgag ttcctgggag 3240 accagatggt caaggatgca gggctgagtt gccgctacat catctcccgc aagcccgagg 3300 gctcccctgt cacggagagg gccatcccac ttgccatttt ccaagcagag cccacggtga 3360 ggaagcactt tctccggaaa tggctcaaga gctcttccct tcaagacttt gatattcgag 3420 caattctgga ttgggactac tacattgagc ggctgggaag cgccatccag aagatcatca 3480 ccatccctgc ggccctgcag caggtaaaga acccagtgcc acgtgtcaaa caccccgact 3540 ggctgcacaa aaaactgctg gagaagaatg atgtctacaa gcagaagaag atcagtgagc 3600 tcttcaccct ggagggcagg agacaggtca cgatggccga ggcctcagaa gacagtccga 3660 ggccaagtgc tcctgacatg gaggacttcg gcctcgtaaa gctgcctcac ccagcagccc 3720 ctgtcactgt gaagaggaag cgagttcttt gggagagcca ggaggagtcc caggacctca 3780 cgccgactgt gccctggcag gaaatcttgg ggcagcctcc cgccctggga accagccagg 3840 aggaatggct tgtctggctc cggttccaca agaagaagtg gcagctgcag gcccggcagc 3900 gcctcgcccg caggaagagg cagcgtctgg agtcggcaga gggtgtgctc aggcccgggg 3960 ccatccggga tggtcctgcc acggggctgg ggagcttctt gcgaagaact gcccgcagca 4020 tcctggacct tccgtggcag attgtgcaga tcagcgagac cagccaggcc ggcctgttca 4080 ggctgtgggc gctcgttggc agtgacttgc actgcatcag gctgagcatc ccccgtgtgt 4140 tctacgtgaa ccagcgagtc gctaaagcgg aggagggtgc ttcgtatcgc aaggtaaatc 4200 gggtccttcc tcgctccaac atggtctaca atctctatga gtattcagtg ccagaggaca 4260 tgtaccagga acacatcaac gagatcaacg ctgagctgtc agcgccagac atcgagggcg 4320 tatatgagac tcaggttccg ttactgttcc gggccctggt gcacctgggc tgtgtgtgtg 4380 tggtcaataa acagctggtg aggcaccttt caggctggga agcagagacc tttgctcttg 4440 agcacctgga gatgcgctct ctggcccagt tcagctacct ggaaccaggg agtatccgcc 4500 atatctacct gtaccaccac gcacaggccc acaaagcgct cttcgggatc ttcatcccct 4560 cacagcgcag ggcatccgtc tttgtgctgg acactgtgcg cagcaaccag atgcccagcc 4620 ttggcgccct gtactcagca gagcacggcc tcctcctgga gaaggtgggc cctgagctcc 4680 tgccaccccc caaacacacc ttcgaagttc gggcagaaac tgacctgaag accatctgca 4740 gagccatcca gcgattcctg ctcgcctaca aggaggagcg ccgggggccc acactcatcg 4800 ctgttcagtc cagctgggag ctgaagaggc tggccagtga aattcctgtc ttggaggaat 4860 tcccactggt gcctatctgt gtggctgaca agatcaacta tggggtcctg gactggcagc 4920 gccatggagc ccggcgcatg atccgtcact acctcaacct ggacacctgc ctgtcgcagg 4980 ccttcgagat gagcaggtac tttcacattc ccattgggaa cctaccagag gacatctcca 5040 cattcggctc cgacctcttc tttgcccgcc acctccagcg ccacaaccac ctgctctggc 5100 tgtcccctac agcccgccct gacctgggtg gaaaggaggc tgatgacaac tgtcttgtca 5160 tggagttcga tgaccaagcc actgttgaga tcaacagttc aggctgttac tccacagtgt 5220 gtgtggagct ggaccttcag aacctggccg tcaacaccat tctccagtct caccatgtca 5280 acgacatgga gggggccgac agcatgggga tcagcttcga cgtgatccag caggcctccc 5340 tggaggacat gatcacgggt ggtcaggctg ccagtgcccc ggccagctac gatgagacag 5400 ccctgtgctc taacaccttc aggatcctga agagcatggt cgtgggctgg gtgaaggaga 5460 tcacccagta ccacaacatc tatgcagaca accaggtgat gcacttctac cgctggcttc 5520 ggtcgccatc ctctctgctt catgaccctg ccctgcaccg cacactccac aacatgatga 5580 agaagctctt cctgcagctc atcgctgagt tcaagcgcct ggggtcatca gtcatctacg 5640 ccaacttcaa ccgcatcatc ctctgtacaa agaagcgccg tgtggaagat gccatcgctt 5700 acgtggagta catcaccagc agcatccatt caaaggagac cttccattct ctgacaattt 5760 ctttctctcg atgctgggaa tttcttctct ggatggatcc atctaactat ggcggaatca 5820 aaggaaaagt ttcatctcgt attcactgtg gactgcaaga ctcccagaaa gcagggggag 5880 cagaggatga gcaggaaaat gaggacgatg aggaggaaag agatggggag gaggaggaag 5940 aggcggagga atccaacgtg gaggatttac tggaaaacaa ctggaacatt ttgcagtttt 6000 tgccacaggc agcctcctgc cagaactact tcctcatgat tgtttcagcg tacatcgtgg 6060 ccgtgtacca ctgcatgaag gacgggctga ggcgcagtgc tccagggagc acccccgtga 6120 ggaggagggg ggccagccag ctctcccagg aggccgaggg ggcggtcgga gcccttcccg 6180 gaatgatcac cttctctcag gattatgtcg caaatgagct cactcagagc ttcttcacca 6240 tcactcagaa gattcagaag aaagtcacag gctctcggaa ctccactgag ctctcagaga 6300 tgtttcctgt cctccccggt tcccacttgc tgctcaataa ccctgccctg gagttcatca 6360 aatacgtgtg caaggtgctg tccctggaca ccaacatcac aaaccaggtg aataagctga 6420 accgagacct gcttcgcctg gtggatgtcg gcgagttctc cgaggaggcc cagttccgag 6480 acccctgccg ctcctacgtg cttcctgagg tcatctgccg cagctgtaac ttctgccgcg 6540 acctggacct gtgtaaagac tcttccttct cagaggatgg ggcggtcctg cctcagtggc 6600 tctgctccaa ctgtcaggcg ccctacgact cctctgccat cgagatgacg ctggtggaag 6660 ttctacagaa gaagctgatg gccttcaccc tgcaggacct ggtctgcctg aagtgccgcg 6720 gggtgaagga gaccagcatg cctgtgtact gcacgtgcgc gggagacttc gccctcacca 6780 tccacaccca ggtcttcatg gaacagatcg gaatattccg gaacattgcc cagcactacg 6840 gcatgtcgta cctcctggag accctggagt ggctgctgca gaagaaccca cagctgggcc 6900 attagccagc cc 6912 <210> 175 <211> 6912 <212> DNA <213> Homo sapiens <400> 175 cgccaaattt ctcccctgaa gcagaggtgg tagccaacgg ctccatgtct ctgaggagcg 60 gcgggcggcg gcgcgcggac ccaggcgcgg atggcgaggc cagcagggat gatggcgcca 120 cttcctcagt ttcggcactc aagcgcctgg aacggagtca gtggacggat aagatggatt 180 tgcggtttgg ttttgagcgg ctgaaggagc ctggtgagaa gacaggctgg ctcattaaca 240 tgcatcctac cgagatttta gatgaagata agcgcttagg cagtgcagtg gattactact 300 ttattcaaga tgacggaagc agatttaagg tggctttgcc ctataaaccg tatttctaca 360 ttgcgaccag aaagggttgt gagcgagaag tttcatcttt tctctccaag aagtttcagg 420 gcaaaattgc aaaagtggag actgtcccca aagaggatct ggacttgcca aatcacttgg 480 tgggtttgaa gcgaaattac atcaggctgt ccttccacac tgtggaggat cttgtcaaag 540 tgaggaagga gatctcccct gccgtgaaga agaacaggga gcaggatcac gccagcgacg 600 cgtacacagc tctgctttcc agtgttctgc agaggggcgg tgtcattact gatgaagagg 660 aaacctctaa gaagatagct gaccagttgg acaacattgt ggacatgcgc gagtacgatg 720 ttccctacca catccgcctc tccattgacc tgaagatcca cgtggctcat tggtacaatg 780 tcagataccg aggaaatgct tttccggtag aaatcacccg ccgagatgac cttgttgaac 840 gacctgaccc tgtggttttg gcatttgaca ttgagacgac caaactgccc ctcaagtttc 900 ctgatgctga gacagaccag attatgatga tttcctacat gatcgatggc cagggctacc 960 tcatcaccaa cagggagatt gtttcagaag atattgaaga ttttgagttc acccccaagc 1020 cagaatatga aggccccttt tgtgtcttca atgaacccga tgaggctcat ctgatccaaa 1080 ggtggtttga acacgtccag gagaccaaac ccaccatcat ggtcacctac aacggggact 1140 tttttgactg gccatttgtg gaggcccggg cagcagtcca cggtctgagc atgcagcagg 1200 agataggctt ccagaaggac agccaggggg agtacaaggc gccccagtgc atccacatgg 1260 actgcctcag gtgggtgaag agggacagtt accttcctgt gggcagtcat aatctcaagg 1320 cggccgccaa ggccaagcta ggctatgatc ccgtggagct agacccggag gacatgtgcc 1380 ggatggccac ggagcagccc cagactctgg ccacgtattc tgtgtcagat gctgtcgcca 1440 cttactacct gtacatgaag tacgtccacc cattcatctt tgctctgtgc accattattc 1500 ccatggagcc cgacgaggtg ctgcggaagg gctctggcac tctgtgtgag gccttgctga 1560 tggtgcaggc cttccacgcc aacatcatct tccccaacaa gcaagagcag gagttcaata 1620 agctgacgga cgacggacac gtgctggact ctgagaccta cgtcgggggc cacgtggagg 1680 ccctcgagtc tggggttttc cgcagcgata tcccttgccg gtttaggatg aatcctgccg 1740 cctttgactt cctgctgcag cgggttgaga agaccttgcg ccacgccctt gaggaagagg 1800 agaaagtgcc tgtggagcaa gtcaccaact ttgaagaggt gtgtgatgag attaagagca 1860 agcttgcctc cctgaaggac gttcccagcc gcatcgagtg tccactcatc taccacctgg 1920 acgtgggggc catgtacccc aacatcatcc tgaccaaccg cctgcagccc tctgccatgg 1980 tggacgaagc cacctgtgct gcctgtgact tcaataagcc tggagcaaac tgccagcgga 2040 agatggcctg gcagtggagg ggcgagttca tgccagccag tcgcagcgaa taccatcgga 2100 tccagcacca gctggagtca gagaagttcc cccccttgtt cccagagggg ccagctcggg 2160 cctttcatga actgtcccgc gaggaacagg cgaaatacga gaagagaagg ctggcggatt 2220 actgccggaa agcctacaag aagatccaca tcaccaaggt ggaagagcgt ctcaccacca 2280 tctgccagcg ggaaaactcc ttctacgtgg acaccgtgcg tgccttccgg gacaggcgtt 2340 acgagttcaa agggctccac aaggtgtgga aaaagaagct ctcggcggcc gtggaggtgg 2400 gcgacgcggc tgaggtgaag cgctgcaaga acatggaggt gctgtatgac tcgctgcagc 2460 tggcccacaa gtgcatcctg aactccttct atggctatgt catgcgcaag ggggctcgct 2520 ggtactccat ggagatggct ggcatcgtct gcttcacagg ggccaacatc atcacccagg 2580 cacgggagct gatcgagcag attgggaggc ccttagagct ggacacagat ggtatatggt 2640 gcgtcctgcc caacagcttc ccagaaaatt ttgtcttcaa gacgaccaat gtgaagaagc 2700 ccaaagtgac catctcctac ccaggcgcca tgttgaacat catggtcaag gaaggcttca 2760 ccaatgacca gtaccaggag ctggctgagc cgtcctcact cacctacgtc acccgctcag 2820 agaacagcat cttttttgag gttgatgggc cctaccttgc catgattctt ccagcctcca 2880 aggaagaagg caagaaattg aagaagaggt atgctgtgtt caatgaagac ggttctctgg 2940 ctgagctcaa gggctttgag gtcaaacgcc gcggggaact gcagctgatt aagatcttcc 3000 aatcctcggt gtttgaggcc ttcctcaagg gcagcacgct ggaagaggtg tatggctctg 3060 tagccaaggt ggctgactac tggctggacg tgctgtacag caaggcagcc aacatgcctg 3120 actctgagct attcgagctc atctctgaga accgttccat gtctcggaag ctggaagatt 3180 acggggagca gaagtctaca tccatcagca cagcaaagcg cctggccgag ttcctgggag 3240 accagatggt caaggatgca gggctgagtt gccgctacat catctcccgc aagcccgagg 3300 gctcccctgt cacggagagg gccatcccac ttgccatttt ccaagcagag cccacggtga 3360 ggaagcactt tctccggaaa tggctcaaga gctcttccct tcaagacttt gatattcgag 3420 caattctgga ttgggactac tacattgagc ggctgggaag cgccatccag aagatcatca 3480 ccatccctgc ggccctgcag caggtaaaga acccagtgcc acgtgtcaaa caccccgact 3540 ggctgcacaa aaaactgctg gagaagaatg atgtctacaa gcagaagaag atcagtgagc 3600 tcttcaccct ggagggcagg agacaggtca cgatggccga ggcctcagaa gacagtccga 3660 ggccaagtgc tcctgacatg gaggacttcg gcctcgtaaa gctgcctcac ccagcagccc 3720 ctgtcactgt gaagaggaag cgagttcttt gggagagcca ggaggagtcc caggacctca 3780 cgccgactgt gccctggcag gaaatcttgg ggcagcctcc cgccctggga accagccagg 3840 aggaatggct tgtctggctc cggttccaca agaagaagtg gcagctgcag gcccggcagc 3900 gcctcgcccg caggaagagg cagcgtctgg agtcggcaga gggtgtgctc aggcccgggg 3960 ccatccggga tggtcctgcc acggggctgg ggagcttctt gcgaagaact gcccgcagca 4020 tcctggacct tccgtggcag attgtgcaga tcagcgagac cagccaggcc ggcctgttca 4080 ggctgtgggc gctcgttggc agtgacttgc actgcatcag gctgagcatc ccccgtgtgt 4140 tctacgtgaa ccagcgagtc gctaaagcgg aggagggtgc ttcgtatcgc aaggtaaatc 4200 gggtccttcc tcgctccaac atggtctaca atctctatga gtattcagtg ccagaggaca 4260 tgtaccagga acacatcaac gagatcaacg ctgagctgtc agcgccagac atcgagggcg 4320 tatatgagac tcaggttccg ttactgttcc gggccctggt gcacctgggc tgtgtgtgtg 4380 tggtcaataa acagctggtg aggcaccttt caggctggga agcagagacc tttgctcttg 4440 agcacctgga gatgcgctct ctggcccagt tcagctacct ggaaccaggg agtatccgcc 4500 atatctacct gtaccaccac gcacaggccc acaaagcgct cttcgggatc ttcatcccct 4560 cacagcgcag ggcatccgtc tttgtgctgg acactgtgcg cagcaaccag atgcccagcc 4620 ttggcgccct gtactcagca gagcacggcc tcctcctgga gaaggtgggc cctgagctcc 4680 tgccaccccc caaacacacc ttcgaagttc gggcagaaac tgacctgaag accatctgca 4740 gagccatcca gcgattcctg ctcgcctaca aggaggagcg ccgggggccc acactcatcg 4800 ctgttcagtc cagctgggag ctgaagaggc tggccagtga aattcctgtc ttggaggaat 4860 tcccactggt gcctatctgt gtggctgaca agatcaacta tggggtcctg gactggcagc 4920 gccatggagc ccggcgcatg atccgtcact acctcaacct ggacacctgc ctgtcgcagg 4980 ccttcgagat gagcaggtac tttcacattc ccattgggaa cctaccagag gacatctcca 5040 cattcggctc cgacctcttc tttgcccgcc acctccagcg ccacaaccac ctgctctggc 5100 tgtcccctac agcccgccct gacctgggtg gaaaggaggc tgatgacaac tgtcttgtca 5160 tggagttcga tgaccaagcc actgttgaga tcaacagttc aggctgttac tccacagtgt 5220 gtgtggagct ggaccttcag aacctggccg tcaacaccat tctccagtct caccatgtca 5280 acgacatgga gggggccgac agcatgggga tcagcttcga cgtgatccag caggcctccc 5340 tggaggacat gatcacgggt ggtcaggctg ccagtgcccc ggccagctac gatgagacag 5400 ccctgtgctc taacaccttc aggatcctga agagcatggt cgtgggctgg gtgaaggaga 5460 tcacccagta ccacaacatc tatgcagaca accaggtgat gcacttctac cgctggcttc 5520 ggtcgccatc ctctctgctt catgaccctg ccctgcaccg cacactccac aacatgatga 5580 agaagctctt cctgcagctc atcgctgagt tcaagcgcct ggggtcatca gtcatctacg 5640 ccaacttcaa ccgcatcatc ctctgtacaa agaagcgccg tgtggaagat gccatcgctt 5700 acgtggagta catcaccagc agcatccatt caaaggagac cttccattct ctgacaattt 5760 ctttctctcg atgctgggaa tttcttctct ggatggatcc atctaactat ggcggaatca 5820 aaggaaaagt ttcatctcgt attcactgtg gactgcaaga ctcccagaaa gcagggggag 5880 cagaggatga gcaggaaaat gaggacgatg aggaggaaag agatggggag gaggaggaag 5940 aggcggagga atccaacgtg gaggatttac tggaaaacaa ctggaacatt ttgcagtttt 6000 tgccacaggc agcctcctgc cagaactact tcctcatgat tgtttcagcg tacatcgtgg 6060 ccgtgtacca ctgcatgaag gacgggctga ggcgcagtgc tccagggagc acccccgtga 6120 ggaggagggg ggccagccag ctctcccagg aggccgaggg ggcggtcgga gcccttcccg 6180 gaatgatcac cttctctcag gattatgtcg caaatgagct cactcagagc ttcttcacca 6240 tcactcagaa gattcagaag aaagtcacag gctctcggaa ctccactgag ctctcagaga 6300 tgtttcctgt cctccccggt tcccacttgc tgctcaataa ccctgccctg gagttcatca 6360 aatacgtgtg caaggtgctg tccctggaca ccaacatcac aaaccaggtg aataagctga 6420 accgagacct gcttcgcctg gtggatgtcg gcgagttctc cgaggaggcc cagttccgag 6480 acccctgccg ctcctacgtg cttcctgagg tcatctgccg cagctgtaac ttctgccgcg 6540 acctggacct gtgtaaagac tcttccttct cagaggatgg ggcggtcctg cctcagtggc 6600 tctgctccaa ctgtcaggcg ccctacgact cctctgccat cgagatgacg ctggtggaag 6660 ttctacagaa gaagctgatg gccttcaccc tgcaggacct ggtctgcctg aagtgccgcg 6720 gggtgaagga gaccagcatg cctgtgtact gcacgtgcgc gggagacttc gccctcacca 6780 tccacaccca ggtcttcatg gaacagatcg gaatattccg gaacattgcc cagcactacg 6840 gcatgtcgta cctcctggag accctggagt ggctgctgca gaagaaccca cagctgggcc 6900 attagccagc cc 6912 <210> 176 <211> 6858 <212> DNA <213> Homo sapiens <400> 176 atgtctctga ggagcggcgg gcggcggcgc gcggacccag gcgcggatgg cgaggccagc 60 agggatgatg gcgccacttc ctcagtttcg gcactcaagc gcctggaacg gagtcagtgg 120 acggataaga tggatttgcg gtttggtttt gagcggctga aggagcctgg tgagaagaca 180 ggctggctca ttaacatgca tcctaccgag attttagatg aagataagcg cttaggcagt 240 gcagtggatt actactttat tcaagatgac ggaagcagat ttaaggtggc tttgccctat 300 aaaccgtatt tctacattgc gaccagaaag ggttgtgagc gagaagtttc atcttttctc 360 tccaagaagt ttcagggcaa aattgcaaaa gtggagactg tccccaaaga ggatctggac 420 ttgccaaatc acttggtggg tttgaagcga aattacatca ggctgtcctt ccacactgtg 480 gaggatcttg tcaaagtgag gaaggagatc tcccctgccg tgaagaagaa cagggagcag 540 gatcacgcca gcgacgcgta cacagctctg ctttccagtg ttctgcagag gggcggtgtc 600 attactgatg aagaggaaac ctctaagaag atagctgacc agttggacaa cattgtggac 660 atgcgcgagt acgatgttcc ctaccacatc cgcctctcca ttgacctgaa gatccacgtg 720 gctcattggt acaatgtcag ataccgagga aatgcttttc cggtagaaat cacccgccga 780 gatgaccttg ttgaacgacc tgaccctgtg gttttggcat ttgacattga gacgaccaaa 840 ctgcccctca agtttcctga tgctgagaca gaccagatta tgatgatttc ctacatgatc 900 gatggccagg gctacctcat caccaacagg gagattgttt cagaagatat tgaagatttt 960 gagttcaccc ccaagccaga atatgaaggc cccttttgtg tcttcaatga acccgatgag 1020 gctcatctga tccaaaggtg gtttgaacac gtccaggaga ccaaacccac catcatggtc 1080 acctacaacg gggacttttt tgactggcca tttgtggagg cccgggcagc agtccacggt 1140 ctgagcatgc agcaggagat aggcttccag aaggacagcc agggggagta caaggcgccc 1200 cagtgcatcc acatggactg cctcaggtgg gtgaagaggg acagttacct tcctgtgggc 1260 agtcataatc tcaaggcggc cgcaagcaag ctaggctatg atcccgtgga gctagacccg 1320 gaggacatgt gccggatggc cacggagcag ccccagactc tggccacgta ttctgtgtca 1380 gatgctgtcg ccacttacta cctgtacatg aagtacgtcc acccattcat ctttgctctg 1440 tgcaccatta ttcccatgga gcccgacgag gtgctgcgga agggctctgg cactctgtgt 1500 gaggccttgc tgatggtgca ggccttccac gccaacatca tcttccccaa caagcaagag 1560 caggagttca ataagctgac ggacgacgga cacgtgctgg actctgagac ctacgtcggg 1620 ggccacgtgg aggccctcga gtctggggtt ttccgcagcg atatcccttg ccggtttagg 1680 atgaatcctg ccgcctttga cttcctgctg cagcgggttg agaagacctt gcgccacgcc 1740 cttgaggaag aggagaaagt gcctgtggag caagtcacca actttgaaga ggtgtgtgat 1800 gagattaaga gcaagcttgc ctccctgaag gacgttccca gccgcatcga gtgtccactc 1860 atctaccacc tggacgtggg ggccatgtac cccaacatca tcctgaccaa ccgcctgcag 1920 ccctctgcca tggtggacga agccacctgt gctgcctgtg acttcaataa gcctggagca 1980 aactgccagc ggaagatggc ctggcagtgg aggggcgagt tcatgccagc cagtcgcagc 2040 gaataccatc ggatccagca ccagctggag tcagagaagt tccccccctt gttcccagag 2100 gggccagctc gggcctttca tgaactgtcc cgcgaggaac aggcgaaata cgagaagaga 2160 aggctggcgg attactgccg gaaagcctac aagaagatcc acatcaccaa ggtggaagag 2220 cgtctcacca ccatctgcca gcgggaaaac tccttctacg tggacaccgt gcgtgccttc 2280 cgggacaggc gttacgagtt caaagggctc cacaaggtgt ggaaaaagaa gctctcggcg 2340 gccgtggagg tgggcgacgc ggctgaggtg aagcgctgca agaacatgga ggtgctgtat 2400 gactcgctgc agctggccca caagtgcatc ctgaactcct tctatggcta tgtcatgcgc 2460 aagggggctc gctggtactc catggagatg gctggcatcg tctgcttcac aggggccaac 2520 atcatcaccc aggcacggga gctgatcgag cagattggga ggcccttaga gctggacaca 2580 gatggtatat ggtgcgtcct gcccaacagc ttcccagaaa attttgtctt caagacgacc 2640 aatgtgaaga agcccaaagt gaccatctcc tacccaggcg ccatgttgaa catcatggtc 2700 aaggaaggct tcaccaatga ccagtaccag gagctggctg agccgtcctc actcacctac 2760 gtcacccgct cagagaacag catctttttt gaggttgatg ggccctacct tgccatgatt 2820 cttccagcct ccaaggaaga aggcaagaaa ttgaagaaga ggtatgctgt gttcaatgaa 2880 gacggttctc tggctgagct caagggcttt gaggtcaaac gccgcgggga actgcagctg 2940 attaagatct tccaatcctc ggtgtttgag gccttcctca agggcagcac gctggaagag 3000 gtgtatggct ctgtagccaa ggtggctgac tactggctgg acgtgctgta cagcaaggca 3060 gccaacatgc ctgactctga gctattcgag ctcatctctg agaaccgttc catgtctcgg 3120 aaactggaag attacgggga gcagaagtct acatccatca gcacagcaaa gcgcctggcc 3180 gagttcctgg gagaccagat ggtcaaggat gcagggctga gttgccgcta catcatctcc 3240 cgcaagcccg agggctcccc tgtcacggag agggccatcc cacttgccat tttccaagca 3300 gagcccacgg tgaggaagca ctttctccgg aaatggctca agagctcttc ccttcaagac 3360 tttgatattc gagcaattct ggattgggac tactacattg agcggctggg aagcgccatc 3420 cagaagatca tcaccatccc tgcggccctg cagcaggtaa agaacccagt gccacgtgtc 3480 aaacaccccg actggctgca caaaaaactg ctggagaaga atgatgtcta caagcagaag 3540 aagatcagtg agctcttcac cctggagggc aggagacagg tcacgatggc cgaggcctca 3600 gaagacagtc cgaggccaag tgctcctgac atggaggact tcggcctcgt aaagctgcct 3660 cacccagcag cccctgtcac tgtgaagagg aagcgagttc tttgggagag ccaggaggag 3720 tcccaggacc tcacgccgac tgtgccctgg caggaaatct tggggcagcc tcccgccctg 3780 ggaaccagcc aggaggaatg gcttgtctgg ctccggttcc acaagaagaa gtggcagctg 3840 caggcccggc agcgcctcgc ccgcaggaag aggcagcgtc tggagtcggc agatggtgtg 3900 ctcaggcccg gggccatccg ggatggtcct gccacggggc tggggagctt cttgcgaaga 3960 actgcccgca gcatcctgga ccttccgtgg cagattgtgc agatcagcga gaccagccag 4020 gccggcctgt tcaggctgtg ggcgctcgtt ggcagtgact tgcactgcat caggctgagc 4080 atcccccgtg tgttctacgt gaaccagcga gtcgctaaag cggaggaggg tgcttcgtat 4140 cgcaaggtaa atcgggtcct tcctcgctcc aacatggtct acaatctcta tgagtattca 4200 gtgccagagg acatgtacca ggaacacatc aacgagatca acgctgagct gtcagcgcca 4260 gacatcgagg gcgtatatga gactcaggtt ccgttactgt tccgggccct ggtgcacctg 4320 ggctgtgtgt gtgtggtcaa taaacagctg gtgaggcacc tttcaggctg ggaagcagag 4380 acctttgctc ttgagcacct ggagatgcgc tctctggccc agttcagcta cctggaacca 4440 gggagtatcc gccatatcta cctgtaccac cacgcacagg cccacaaagc gctcttcggg 4500 atcttcatcc cctcacagcg cagggcatcc gtctttgtgc tggacactgt gcgcagcaac 4560 cagatgccca gccttggcgc cctgtactca gcagagcacg gcctcctcct ggagaaggtg 4620 ggccctgagc tcctgccacc ccccaaacac accttcgaag ttcgggcaga aactgacctg 4680 aagaccatct gcagagccat ccagcgattc ctgctcgcct acaaggagga gcgccggggg 4740 cccacactca tcgctgttca gtccagctgg gagctgaaga ggctggccag tgaaattcct 4800 gtcttggagg aattcccact ggtgcctatc tgtgtggctg acaagatcaa ctatggggtc 4860 ctggactggc agcgccatgg agcccggcgc atgatccgtc actacctcaa cctggacacc 4920 tgcctgtcgc aggccttcga gatgagcagg tactttcaca ttcccattgg gaacctacca 4980 gaggacatct ccacattcgg ctccgacctc ttctttgccc gccacctcca gcgtcacaac 5040 cacctgctct ggctgtcccc tacagcccgc cctgacctgg gtggaaagga ggctgatgac 5100 aactgtcttg tcatggagtt cgatgaccaa gccactgttg agatcaacag ttcaggctgt 5160 tactccacag tgtgtgtgga gctggacctt cagaacctgg ccgtcaacac cattctccag 5220 tctcaccatg tcaacgacat ggagggggcc gacagcatgg ggatcagctt cgacgtgatc 5280 cagcaggcct ccctggagga catgatcacg ggtggtcagg ctgccagtgc cccggccagc 5340 tacgatgaga cagccctgtg ctctaacacc ttcaggatcc tgaagagcat ggtcgtgggc 5400 tgggtgaagg agatcaccca gtaccacaac atctatgcag acaaccaggt gatgcacttc 5460 taccgctggc ttcggtcgcc atcctctctg cttcatgacc ctgccctgca ccgcacactc 5520 cacaacatga tgaagaagct cttcctgcag ctcatcgctg agttcaagcg cctggggtca 5580 tcagtcatct acgccaactt caaccgcatc atcctctgta caaagaagcg ccgtgtggaa 5640 gatgccatcg cttacgtgga gtacatcacc agcagcatcc attcaaagga gaccttccat 5700 tctctgacaa tttctttctc tcgatgctgg gaatttcttc tctggatgga tccatctaac 5760 tatggcggaa tcaaaggaaa agtttcatct cgtattcact gtggactgca agactcccag 5820 aaagcagggg gagcagagga tgagcaggaa aatgaggacg atgaggagga aagagatggg 5880 gaggaggagg aagaggcgga ggaatccaac gtggaggatt tactggaaaa caactggaac 5940 attttgcagt ttttgccaca ggcagcctcc tgccagaact acttcctcat gattgtttca 6000 gcgtacatcg tggccgtgta ccactgcatg aaggacgggc tgaggcgcag tgctccaggg 6060 agcacccccg tgaggaggag gggggccagc cagctctccc aggaggccga gggggcggtc 6120 ggagcccttc ccggaatgat caccttctct caggattatg tcgcaaatga gctcactcag 6180 agcttcttca ccatcactca gaagattcag aagaaagtca caggctctcg gaactccact 6240 gagctctcgg agatgtttcc tgtcctcccc ggttcccact tgctgctcaa taaccctgcc 6300 ctggagttca tcaaatacgt gtgcaaggtg ctgtccctgg acaccaacat cacaaaccag 6360 gtgaataagc tgaaccgaga cctgcttcgc ctggtggatg tcggcgagtt ctccgaggag 6420 gcccagttcc gagacccctg ccgctcctac gtgcttcctg aggtcatctg ccgcagctgt 6480 aacttctgcc gcgacctgga cctgtgtaaa gactcttcct tctcagagga tggggcggtc 6540 ctgcctcagt ggctctgctc caactgtcag gcgccctacg actcctctgc catcgagatg 6600 acgctggtgg aagttctaca gaagaagctg atggccttca ccctgcagga cctggtctgc 6660 ctgaagtgcc gcggggtgaa ggagaccagc atgcctgtgt actgcagctg cgcgggagac 6720 ttcgccctca ccatccacac ccaggtcttc atggaacaga tcggaatatt ccggaacatt 6780 gcccagcact acggcatgtc gtacctcctg gagaccctgg agtggctgct gcagaagaac 6840 ccacagctgg gccattag 6858 <210> 177 <211> 6794 <212> DNA <213> Homo sapiens <400> 177 agccaacggc tccatgtctc tgaggagcgg cgggcggcgg cgcgcggacc caggcgcgga 60 tggcgaggcc agcagggatg atggcgccac ttcctcagtt tcggcactca agcgcctgga 120 acggagtcag tggacggata agatggattt gcggtttggt tttgagcggc tgaaggagcc 180 tggtgagaag acaggctggc tcattaacat gcatcctgtg gctttgccct ataaaccgta 240 tttctacatt gcgaccagaa agggttgtga gcgagaagtt tcatcttttc tctccaagaa 300 gtttcagggc aaaattgcaa aagtggagac tgtccccaaa gaggatctgg acttgccaaa 360 tcacttggtg ggtttgaagc gaaattacat caggctgtcc ttccacactg tggaggatct 420 tgtcaaagtg aggaaggaga tctcccctgc cgtgaagaag aacagggagc aggatcacgc 480 cagcgacgcg tacacagctc tgctttccag tgttctgcag aggggcggtg tcattactga 540 tgaagaggaa acctctaaga agatagctga ccagttggac aacattgtgg acatgcgcga 600 gtacgatgtt ccctaccaca tccgcctctc cattgacctg aagatccacg tggctcattg 660 gtacaatgtc agataccgag gaaatgcttt tccggtagaa atcacccgcc gagatgacct 720 tgttgaacga cctgaccctg tggttttggc atttgacatt gagacgacca aactgcccct 780 caagtttcct gatgctgaga cagaccagat tatgatgatt tcctacatga tcgatggcca 840 gggctacctc atcaccaaca gggagattgt ttcagaagat attgaagatt ttgagttcac 900 ccccaagcca gaatatgaag gccccttttg tgtcttcaat gaacccgatg aggctcatct 960 gatccaaagg tggtttgaac acgtccagga gaccaaaccc accatcatgg tcacctacaa 1020 cggggacttt tttgactggc catttgtgga ggcccgggca gcagtccacg gtctgagcat 1080 gcagcaggag ataggcttcc agaaggacag ccagggggag tacaaggcgc cccagtgcat 1140 ccacatggac tgcctcaggt gggtgaagag ggacagttac cttcctgtgg gcagtcataa 1200 tctcaaggcg gccgcaagca agctaggcta tgatcccgtg gagctagacc cggagacatg 1260 tgccggatcg acggagcagc cccagactct ggccacgtat tctgtgtcag atgctgtcgc 1320 cacttactac ctgtacatga agtacgtcca cccattcatc tttgctctgt gcaccattat 1380 tcccatggag cccgacgagg tgctgcggaa gggctctggc actctgtgtg aggccttgct 1440 gatggtgcag gccttccacg ccaacatcat cttccccaac aagcaagagc aggagttcaa 1500 taagctgacg gacgacggac acgtgctgga ctctgagacc tacgtcgggg gccacgtgga 1560 ggccctcgag tctggggttt tccgcagcga tatcccttgc cggtttagga tgaatcctgc 1620 cgcctttgac ttcctgctgc agcgggttga gaagaccttg cgccacgccc ttgaggaaga 1680 ggagaaagtg cctgtggagc aagtcaccaa ctttgaagag gtgtgtgatg agattaagag 1740 caagcttgcc tccctgaagg acgttcccag ccgcatcgag tgtccactca tctaccacct 1800 ggacgtgggg gccatgtacc ccaacatcat cctgaccaac cgcctgcagc cctctgccat 1860 ggtggacgaa gccacctgtg ctgcctgtga cttcaataag cctggagcaa actgccagcg 1920 gaagatggcc tggcagtgga ggggcgagtt catgccagcc agtcgcagcg aataccatcg 1980 gatccagcac cagctggagt cagagaagtt cccccccttg ttcccagagg ggccagctcg 2040 ggcctttcat gaactgtccc gcgaggaaca ggcgaaatac gagaagagaa ggctggcgga 2100 ttactgccgg aaagcctaca agaagatcca catcaccaag gtggaagagc gtctcaccac 2160 catctgccag cgggaaaact ccttctacgt ggacaccgtg cgtgccttcc gggacaggcg 2220 ttacgagttc aaagggctcc acaaggtgtg gaaaaagaag ctctcggcgg ccgtggaggt 2280 gggcgacgcg gctgaggtga agcgctgcaa gaacatggag gtgctgtatg actcgctgca 2340 gctggcccac aagtgcatcc tgaactcctt ctatggctat gtcatgcgca agggggctcg 2400 ctggtactcc atggagatgg ctggcatcgt ctgcttcaca ggggccaaca tcatcaccca 2460 ggcacgggag ctgatcgagc agattgggag gcccttagag ctggacacag atggtatatg 2520 gtgcgtcctg cccaacagct tcccagaaaa ttttgtcttc aagacgacca atgtgaagaa 2580 gcccaaagtg accatctcct acccaggcgc catgttgaac atcatggtca aggaaggctt 2640 caccaatgac cagtaccagg agctggctga gccgtcctca ctcacctacg tcacccgctc 2700 agagaacagc atcttttttg aggttgatgg gccctacctt gccatgattc ttccagcctc 2760 caaggaagaa ggcaagaaat tgaagaagag gtatgctgtg ttcaatgaag acggttctct 2820 ggctgagctc aagggctttg aggtcaaacg ccgcggggaa ctgcagctga ttaagatctt 2880 ccaatcctcg gtgtttgagg ccttcctcaa gggcagcacg ctggaagagg tgtatggctc 2940 tgtagccaag gtggctgact actggctgga cgtgctgtac agcaaggcag ccaacatgcc 3000 tgactctgag ctattcgagc tcatctctga gaaccgttcc atgtctcgga agctggaaga 3060 ttacggggag cagaagtcta cgtccatcag cacagcaaag cgcctggccg agttcctggg 3120 agaccagatg gtcaaggatg cagggctgag ttgccgctac atcatctccc gcaacgccga 3180 gggctcccct gtcacggaga gggccatccc acttgccatt ttccaagcag agcccacggt 3240 gaggaagcac tttctccgga aatggctcaa gagctcttcc cttcaagact ttgatattcg 3300 agcaattctg gattgggact actacattga gcggctggga agcgccatcc agaagatcat 3360 caccatccct gcggccctgc agcaggtaaa gaacccagtg ccacgtgtca aacaccccga 3420 ctggctgcac aaaaaactgc tggagaagaa tgatgtctac aagcagaaga agatcagtga 3480 gctcttcacc ctggagggca ggagacaggt cacgatggcc gaggcctcag aagacagtcc 3540 gaggccaagt gctcctgaca tggaggactt cggcctcgta aagctgcctc acccagcagc 3600 ccctgtcact gtgaagagga agcgagttct ttgggagagc caggaggagt cccaggacct 3660 cacgccgact gtgccctggc aggaaatctt ggggcagcct cccgccctgg gaaccagcca 3720 ggaggaatgg cttgtctggc tccggttcca caagaagaag tggcagctgc aggcccggca 3780 gcgcctcgcc cgcaggaaga ggcagcgtct ggagtcggca gagggtgtgc tcaggcccgg 3840 ggccatccgg gatggtcctg ccacggggct ggggagcttc ttgcgaagaa ctgcccgcag 3900 catcctggac cttccgtggc agattgtgca gatcagcgag accagccagg ccggcctgtt 3960 caggctgtgg gcgctcgttg gcagtgactt gcactgcatc aggctgagca tcccccgtgt 4020 gttctacgtg aaccagcgag tgcctaaagc ggaggagggt gcttcgtatc gcaaggtaaa 4080 tcgggtcctt cctcgctcca acatggtcta caatctctat gagtattcag tgccagagga 4140 catgtaccag gaacacatca acgagatcaa cgctgagctg tcagcgccag acatcgaggg 4200 cgtatatgag actcaggttc cgttactgtt ccgggccctg gtgcacctgg gctgtgtgtg 4260 tgtggtcaat aaacagctgg tgaggcacct ttcaggctgg gaagcagaga cctttgctct 4320 tgagcacctg gagatgcgct ctctggccca gttcagctac ctggaaccag ggagtatccg 4380 ccatatctac ctgtaccacc acgcacaggc ccacaaagcg ctcttcggga tcttcatccc 4440 ctcacagcgc agggcatccg tctttgtgct ggacactgtg cgcacagacc agatgcccag 4500 ccttggcgcc ctgtactcag cagagcacgg cctcctcctg gagaaggtgg gccctgagct 4560 cctgccaccc cccaaacaca ccttcgaagt tcgggcagaa actgacctga agaccatctg 4620 cagagccatc cagcgattcc tgctcgccta caaggaggag cgccgggggc ccacactcat 4680 cgctgttcag tccagctggg agctgaagag gctggccagt gaaattcctg tcttggagga 4740 attcccactg gtgcctatct gtgtggctga caagatcaac tatggggtcc tggactggca 4800 gcgccatgga gcccggcgca tgatccgtca ctacctcaac ctggacacct gcctgtcgca 4860 ggccttcgag atgagcaggt actttcacat tcccattggg aacctaccag aggacatctc 4920 cacattcggc tccgacctct tctttgcccg ccacctccag cgccacaacc acctgctctg 4980 gctgtcccct acagcccgcc ctgacctggg tggaaaggag gctgatgaca actgtcttgt 5040 catggagttc gatgaccaag ccactgttga gatcaacagt tcaggctgtt actccacagt 5100 gtgtgtggag ctggaccttc agaacctggc cgtcaacacc attctccagt ctcaccatgt 5160 caacgacatg gagggggccg acagcatggg gatcagcttc gacgtgatcc agcaggcctc 5220 cctggaggac atgatcacgg gtggtcaggc tgccagtgcc ccggccagct acgatgagac 5280 agccctgtgc tctaacacct tcaggatcct gaagagcatg gtcgtgggct gggtgaagga 5340 gatcacccag taccacaaca tctatgcaga caaccaggtg atgcacttct accgctggct 5400 tcggtcgcca tcctctctgc ttcatgaccc tgccctgcac cgcacactcc acaacatgat 5460 gaagaagctc ttcctgcagc tcatcgctga gttcaagcgc ctggggtcat cagtcatcta 5520 cgccaacttc aaccgcatca tcctctgtac aaagaagcgc cgtgtggaag atgccatcgc 5580 ttacgtggag tacatcacca gcagcatcca ttcaaaggag accttccatt ctctgacaat 5640 ttctttctct cgatgctggg aatttcttct ctggatggat ccatctaact atggcggaat 5700 caaaggaaaa gtttcatctc gtattcactg tggactgcaa gactcccaga aagcaggggg 5760 agcagaggat gagcaggaaa atgaggacga tgaggaggaa agagatgggg aggaggagga 5820 agaggcggag gaatccaacg tggaggattt actggaaaac aactggaaca ttttgcagtt 5880 tttgccacag gcagcctcct gccagaacta cttcctcatg attgtttcag cgtacatcgt 5940 ggccgtgtac cactgcatga aggacgggct gaggcgcagt gctccaggga gcacccccgt 6000 gaggaggagg ggggccagcc agctctccca ggaggccgag ggggcggtcg gagcccttcc 6060 cggaatgatc accttctctc aggattatgt cgcaaatgag ctcactcaga gcttcttcac 6120 catcactcag aagattcaga agaaagtcac aggctctcgg aactccactg agctctcaga 6180 gatgtttcct gtcctccccg gttcccactt gctgctcaat aaccctgccc tggagttcat 6240 caaatacgtg tgcaaggtgc tgtccctgga caccaacatc acaaaccagg tgaataagct 6300 gaaccgagac ctgcttcgcc tggtggatgt cggcgagttc tccgaggagg cccagttccg 6360 agacccctgc cgctcctacg tgcttcctga ggtcatctgc cgcagctgta acttctgccg 6420 cgacctggac ctgtgtaaag actcttcctt ctcagaggat ggggcggtcc tgcctcagtg 6480 gctctgctcc aactgtcagg cgccctacga ctcctctgcc atcgagatga cgctggtgga 6540 agttctacag aagaagctga tggccttcac cctgcaggac ctggtctgcc tgaagtgccg 6600 cggggtgaag gagaccagca tgcctgtgta ctgcacgtgc gcgggagact tcgccctcac 6660 catccacacc caggtcttca tggaacagat cggaatattc cggaacattg cccagcacta 6720 cggcatgtcg tacctcctgg agaccctgga gtggctgctg cagaagaacc cacagctggg 6780 ccattagcca gccc 6794 <210> 178 <211> 5469 <212> DNA <213> Homo sapiens <400> 178 tttttttttt tttttttcgg tggttatata caaataggac cagtacaaat gcctgcatgg 60 ggttgatgaa caccagaata agggttgtct ttacttctgt gtgaggaggg aataggttgg 120 ggtcacacag ggcttcactc taatcgtctc acaaaggaag tcagagtggc caagtgttga 180 agcttgatgg agccgagtgg atcgtagtgt gcgtgtcttc tttaggtctc cttatgtttg 240 cagtattcac cacagatgtt tcctccagtg aaagggaagc actgacggtt gccagttgct 300 ttgctagtga catgaaaaca ggctcgtttt ttctagaaag cagcctgagt cttctgtgtg 360 ttactcagca aggaacatgt agacatggtt atgaacgtgc acgtttgcct gtatgcatgc 420 acgtggttac tcagaaacgc agacatgttt acgcacacac gcatgtcttt gcctatacgc 480 atgcgcgtgg ttactcagaa acgtagacat gtttacgcac gcatgcgttt atgtatgtgc 540 atgcacatgg ttatgccgtg agaaacatgt agacatagtt acgaacatgc acgtgtttgc 600 ctgtacgcat gcacgtggtt actcaatgag aaacgcagac atgtctacgc acacgcatgt 660 gtttatgtat atgcatgccc atggttacgc tgtgaggaac atgtagacat gtttacgtgc 720 acacacgcac gtgtttacac atacgcacgt gttactcccc gaggaacctg taggcatgtt 780 tgtgcataca tatgcacgca gatgtataca ttgatgtttg tgaacagctg ttacacgtcc 840 ttatttccat gttcatttga taagagttag gatcagattt tgggtgattt tcactgttac 900 tgagctgtgt gcctgtcttc cttacccagg gccatcccac ttgccatttt ccaagcagag 960 cccacggtga ggaagcactt tctccggaaa tggctcaaga gctcttccct tcaagacttt 1020 gatattcgag caattctgga ttgggactac tacattgagc ggctgggaag cgccatccag 1080 aagatcatca ccatccctgc ggccctgcag caggtaaaga acccagtgcc acgtgtcaaa 1140 caccccgact ggctgcacaa aaaactgctg gagaagaatg atgtctacaa gcagaagaag 1200 atcagtgagc tcttcaccct ggagggcagg agacaggtca cgatggccga ggcctcagaa 1260 gacagtccga ggccaagtgc tcctgacatg gaggacttcg gcctcgtaaa gctgcctcac 1320 ccagcagccc ctgtcactgt gaagaggaag cgagttcttt gggagagcca ggaggagtcc 1380 caggacctca cgccgactgt gccctggcag gaaatcttgg ggcagcctcc cgccctggga 1440 accagccagg aggaatggct tgtctggctc cggttccaca agaagaagtg gcagctgcag 1500 gcccggcagc gcctcgcccg caggaagagg cagcgtctgg agtcggcaga gggtgtgctc 1560 aggcccgggg ccatccggga tggtcctgcc acggggctgg ggagcttctt gcgaagaact 1620 gcccgcagca tcctggacct tccgtggcag attgtgcaga tcagcgagac cagccaggcc 1680 ggcctgttca ggctgtgggc gctcgttggc agtgacttgc actgcatcag gctgagcatc 1740 ccccgtgtgt tctacgtgaa ccagcgagtc gctaaagcgg aggagggtgc ttcgtatcgc 1800 aaggtaaatc gggtccttcc tcgctccaac atggtctaca atctctatga gtattcagtg 1860 ccagaggaca tgtaccagga acacatcaac gagatcaacg ctgagctgtc agcgccagac 1920 atcgagggcg tatatgagac tcaggttccg ttactgttcc gggccctggt gcacctgggc 1980 tgtgtgtgtg tggtcaataa acagctggtg aggcaccttt caggctggga agcagagacc 2040 tttgctcttg agcacctgga gatgcgctct ctggcccagt tcagctacct ggaaccaggg 2100 agtatccgcc atacctacct gtaccaccac gcacaggccc acaaagcgct cttcgggatc 2160 ttcatcccct cacagcgcag ggcatccgtc tttgtgctgg acactgtgcg cagcaaccag 2220 atgcccagcc ttggcgccct gtactcagca gagcacggcc tcctcctgga gaaggtgggc 2280 cctgagctcc tgccaccccc caaacacacc ttcgaagttc gggcagaaac tgacctgaag 2340 accatctgca gagccatcca gcgattcctg ctcgcctaca aggaggagcg ccgggggccc 2400 acactcatcg ctgttcagtc cagctgggag ctgaagaggc tggccagtga aattcctgtc 2460 ttggaggaat tcccactggt gcctatctgt gtggctgaca agatcaacta tggggtcccg 2520 gactggcagc gccatggagc ccggcgcatg atccgtcact acctcaacct ggacacctgc 2580 ctgtcgcagg ccttcgagat gagcaggtac tttcacattc ccattgggaa cctaccagag 2640 gacatctcca cattcggctc cgacctcttc tttgcccgcc acctccagcg ccacaaccac 2700 ctgctctggc tgtcccctac agcccgccct gacctgggtg gagaggaggc tgatgacaac 2760 tgtcttgtca tggagttcga tgaccaagcc actgttgaga tcaacagttc aggctgttac 2820 tccacagtgt gtgtggagct ggaccttcag aacctggccg tcaacaccat tctccagtct 2880 caccatgtca acgacatgga gggggccgac agcatgggga tcagcttcga cgtgatccag 2940 caggcctccc tggaggacat gatcacgggt ggtcaggctg ccagtgcccc ggccagctac 3000 gatgagacag ccctgtgctc taacaccttc aggatcctga agagcatggt cgtgggctgg 3060 gtgaaggaga tcacccagta ccacaacatc tatgcagaca accaggtgat gcacttctac 3120 cgctggcttc ggtcgccatc ctctctgctt catgaccctg ccctgcaccg cacactccac 3180 aacatgatga agaagctctt cctgcagctc atcgctgagt tcaagcgcct ggggtcatca 3240 gtcatctacg ccaacttcaa ccgcatcatc ctctgtacaa agaagcgccg tgtggaagat 3300 gccatcgctt acgtggagta catcaccagc agcatccatt caaaggagac cttccattct 3360 ctgacaattt ctttctctcg atgctgggaa tttcttctct ggatggatcc atctaactat 3420 ggcggaatca aaggaaaagt ttcatctcgt attcactgtg gactgcaaga ctcccagaaa 3480 gcagggggag cagaggatga gcaggaaaat gaggacgatg aggaggaaag agatggggag 3540 gaggaggaag aggcggagga atccaacgtg gaggatttac aggaaaacaa ctggaacatt 3600 ttgcagtttt tgccacaggc agcctcctgc cagaactact tcctcatgat tgtttcagcg 3660 tacatcgtgg ccgtgtacca ctgcatgaag gacgggctga ggcgcagtgc tccagggagc 3720 acccccgtga ggaggagggg ggccagccag ctctcccagg aggccgaggg ggcggtcgga 3780 gcccttcccg gaatgatcac cttctctcag gattatgtcg caaatgagct cactcagagc 3840 ttcttcacca tcactcagaa gattcagaag aaagtcacag gctctcggaa ctccactgag 3900 ctctcagaga tgtttcctgt cctccccggt tcccacttgc tgctcaataa ccctgccctg 3960 gagttcatca aatacgtgtg caaggtgctg tccctggaca ccaacatcac aaaccaggtg 4020 aataagctga accgagacct gcttcgcctg gtggatgtcg gcgagttctc cgaggaggcc 4080 cagttccgag acccctgccg ctcctacgtg cttcctgagg tcatctgccg cagctgtaac 4140 ttctgccgcg acctggacct gtgtaaagac tcttccttct cagaggatgg ggcggtcctg 4200 cctcagtggc tctgctccaa ctgtcaggcg ccctacgact cctctgccat cgagatgacg 4260 ctggtggaag ttctacagaa gaagctgatg gccttcaccc tgcaggacct ggtctgcctg 4320 aagtgccgcg gggtgaagga gaccagcatg cctgtgtact gcagctgcgc gggagacttc 4380 gccctcacca tccacaccca ggtcttcatg gaacagatcg gaatattccg gaacattgcc 4440 cagcactacg gcatgtcgta cctcctggag accctggagt ggctgctgca gaagaaccca 4500 cagctgggcc attagccagc cccgggcccc gggtgcctct gcgtccgtgc caggcctcct 4560 gatgccaagg ccacatcccc gtgcttccag tgaccagacc actgaccacc ctgactgtcc 4620 aaacctgtga ccccaggcca gggaacgggg aggaaaccaa agaaaaccat tttcagggag 4680 ctcagacgtc acaggaggga gcgggagcag gatgtggccc tggcctcgcc agagcacctg 4740 aagaagcagg ccgtgagcga ggctgcgagt gccctgggcg ccgtttctca cgcagtgaat 4800 gcttttccag gcctctgttg cttcctgcac cacacctggt ggggtgggag cgtcctctag 4860 gtgcccctag ttctttgtcc tgcctcccag agggaggaaa agcccctggg ggcttctggc 4920 tccctgagat tgggctctga gacgagacgg gttcccaagg ccctggtggg gctggagtct 4980 cacctgtttg catggagaaa tgggctggcc ccacagcctc acaggagcag tttgtgggct 5040 ggtttcccca ggaatccaga ccctaacccg tgagaatctg gattttggct tgtgagccct 5100 gcttatttgg agccgggtct agagggaacc ctctatcagc ctcaggaaaa caagacctct 5160 gtgcacctca cttttggctc actgcagccc ttgtccttca cctccacaca ggaccagctg 5220 gaagcagaaa gaagaaaggc caatttcaca gggcaccaaa caagtatgaa atgtaaatca 5280 gaaatgcaga caccccagac gagagcctca caggagggag ggggccccac aggctcccca 5340 ggaggctcgt gtctttggcc cagagccagc cttagtttgt ccctgccatc tactgtctga 5400 ggccatcgct gctacacttt gtttttattt gtatttcata ctgaagtttc aaaaaaaaaa 5460 aaaaaaaaa 5469 <210> 179 <211> 3349 <212> DNA <213> Homo sapiens <400> 179 tgtaccacca cgcacaggcc cacaaagcgc tcttcgggat cttcatcccc tcacagcgca 60 gggcgtccgt ctttgtgctg gacactgtgc gcagcaacca gatgcccagc cttggcgccc 120 tgtactcagc agagcacggc ctcctcctgg agaaggtggg ccctgagctc ctgccacccc 180 ccaaacacac cttcgaagtt cgggcagaaa ctgacctgaa gaccatctgc agagccatcc 240 agcgattcct gctcgcctac aaggaggagc gccgggggcc cacactcatc gctgttcagt 300 ccagctggga gctgaagagg ctggccagtg aaattcctgt cttggaggaa ttcccactgg 360 tgcctatctg tgtggctgac aagatcaact atggggtcct ggactggcag cgccatggag 420 cccggcgcat gatccgtcac tacctcaacc tggacacctg cctgtcgcag gccttcgaga 480 tgagcaggta ctttcacatt cccattggga acctaccaga ggacatctcc acattcggct 540 ccgacctctt ctttgcccgc cacctccagc gccacaacca cctgctctgg ctgtccccta 600 cagcccgccc tgacctgggt ggaaaggagg ctgatgacaa ctgtcttgtc atggagttcg 660 atgaccaagc cactgttgag atcaacagtt caggctgtta ctccacagtg tgtgtggagc 720 tggaccttca gaacctggcc gtcaacacca ttctccagtc tcaccatgtc aacgacatgg 780 agggggccga cagcatgggg atcagcttcg acgtgatcca gcaggcctcc ctggaggaca 840 tgatcacggg tggtcaggct gccagtgccc cggccagcta cgatgagaca gccctgtgct 900 ctaacacctt caggatcctg aagagcatgg tcgtgggctg ggtgaaggag atcacccagt 960 accacaacat ctatgcagac aaccaggtga tgcacttcta ccgctggctt cggtcgccat 1020 cctctctgct tcatgaccct gccctgcacc gcacactcca caacatgatg aagaagctct 1080 tcctgcagct catcgctgag ttcaagcgcc tggggtcatc agtcatctac gccaacttca 1140 accgcatcat cctctgtaca aagaagcgcc gtgtggaaga tgccatcgct tacgtggagt 1200 acatcaccag cagcatccat tcaaaggaga ccttccattc tctgacaatt tctttctctc 1260 gatgctggga atttcttctc tggatggatc catctaacta tggcggaatc aaaggaaaag 1320 tttcatctcg tattcactgt ggactgcaag actcccagaa agcaggggga gcagaggatg 1380 agcaggaaaa tgaggacgat gaggaggaaa gagatgggga ggaggaggaa gaggcggagg 1440 aatccaacgt ggaggattta ctggaaaaca actggaacat tttgcagttt ttgccacagg 1500 cagcctcctg ccagaactac ttcctcatga ttgtttcagc gtacatcgtg gccgtgtacc 1560 actgcatgaa ggacgggctg aggcgcagtg ctccagggag cacccccgtg aggaggaggg 1620 gggccagcca gctctcccag gaggccgagg gggcggtcgg agcccttccc ggaatgatca 1680 ccttctctca ggattatgtc gcaaatgagc tcactcagag cttcttcacc atcactcaga 1740 agattcagaa gaaagtcaca ggctctcgga actccactga gctctcggag atgtttcctg 1800 tcctccccgg ttcccacttg ctgctcaata accctgccct ggagttcatc aaatacgtgt 1860 gcaaggtgct gtccctggac accaacatca caaaccaggt gaataagctg aaccgagacc 1920 tgcttcgcct ggtggatgtc ggcgagttct ccgaggaggc ccagttccga gacccctgcc 1980 gctcctacgt gcttcctgag gtcatctgcc gcagctgtaa cttctgccgc gacctggacc 2040 tgtgtaaaga ctcttccttc tcagaggatg gggcggtcct gcctcagtgg ctctgctcca 2100 actgtcaggc gccctacgac tcctctgcca tcgagatgac gctggtggaa gttctacaga 2160 agaagctgat ggccttcacc ctgcaggacc tggtctgcct gaagtgccgc ggggtgaagg 2220 agaccagcat gcctgtgtac tgcagctgcg cgggagactt cgccctcacc atccacaccc 2280 aggtcttcat ggaacagatc ggaatattcc ggaacattgc ccagcactac ggcatgtcgt 2340 acctcctgga gaccctggag tggctgctgc agaagaaccc acagctgggc cattagccag 2400 ccccgggccc cgggtgcctc tgcgtccgtg ccaggcctcc tgatgccaag gccacatccc 2460 cgtgcttcca gtgaccagac cactgaccac cctgactgtc caaacctgtg accccaggcc 2520 agggaacggg gaggaaacca aagaaaacca ttttcaggga gctcagacgt cacaggaggg 2580 agcgggagca ggatgtggcc ctggcctcgc cagagcacct gaagaagcag gccgtgagcg 2640 aggctgcgag tgccctgggc gccgtttctc acgcagtgaa tgcttttcca ggcctctgtt 2700 gcttcctgca ccacacctgg tggggtggga gcgtcctcta ggtgccccta gttctttgtc 2760 ctgcctccca gagggaggaa aagcccctgg gggcttctgg ctccctgaga ttgggctctg 2820 agacgagacg ggttcccaag gccctggtgg ggctggagtc tcacctgttt gcatggagaa 2880 atgggctggc cccacagcct cacaggagca gtttgtgggc tggtttcccc gggaatccag 2940 accctaaccc gtgagaatct ggattttggc ttgtgagccc tgcttatttg gagccgggtc 3000 tagagggaac cctctatcag cctcaggaaa acaagacctc tgtgcacctc acttttggct 3060 cactgcagcc cttgtccttc acctccacac aggaccagct ggaagcagaa agaagaaagg 3120 ccaatttcac agggcaccaa acaagtatga aatgtaaatc agaaatgcag acaccccaga 3180 cgagagcctc acaggaggga gggggcccca caggctcccc aggaggctcg tgtctttggc 3240 ccagagccag ccttagtttg tccctgccat ctactgtctg aggccatcgc tgctacactt 3300 tgtttttatt tgtatttcat actgaagttt caaaaaaaaa aaaaaaaaa 3349 <210> 180 <211> 2334 <212> DNA <213> Homo sapiens <400> 180 ctctctgctt catgaccctg ccctgcaccg cacactccac aacatgatga agaagctctt 60 cctgcagctc atcgctgagt tcaagcgcct ggggtcatca gtcatctacg ccaacttcaa 120 ccgcatcatc ctctgtacaa agaagcgccg tgtggaagat gccatcgctt acgtggagta 180 catcaccagc agcatccatt caaaggagac cttccattct ctgacaattt ctttctctcg 240 atgctgggaa tttcttctct ggatggatcc atctaactat ggcggaatca aaggaaaagt 300 ttcatctcgt attcactgtg gactgcaaga ctcccagaaa gcagggggag cagaggatga 360 gcaggaaaat gaggacgatg aggaggaaag agatggggag gaggaggaag aggcggagga 420 atccaacgtg gaggatttac tggaaaacaa ctggaacatt ttgcagtttt tgccacaggc 480 agcctcctgc cagaactact tcctcatgat tgtttcagcg tacatcgtgg ccgtgtacca 540 ctgcatgaag gacgggctga ggcgcagtgc tccagggagc acccccgtga ggaggagggg 600 ggccagccag ctctcccagg aggccgaggg ggcggtcgga gcccttcccg gaatgatcac 660 cttctctcag gattatgtcg caaatgagct cactcagagc ttcttcacca tcactcagaa 720 gattcagaag aaagtcacag gctctcggaa ctccactgag ctctcagaga tgtttcctgt 780 cctccccggt tcccacttgc tgctcaataa ccctgccctg gagttcatca aatacgtgtg 840 caaggtgctg tccctggaca ccaacatcac aaaccaggtg aataagctga accgagacct 900 gcttcgcctg gtggatgtcg gcgagttctc cgaggaggcc cagttccgag acccctgccg 960 ctcctacgtg cttcctgagg tcatctgccg cagctgtaac ttctgccgcg acctggacct 1020 gtgtaaagac tcttccttct cagaggatgg ggcggtcctg cctcagtggc tctgctccaa 1080 ctgtcaggcg ccctacgact cctctgccat cgagatgacg ctggtggaag ttctacagaa 1140 gaagctgatg gccttcaccc tgcaggacct ggtctgcctg aagtgccgcg gggtgaagga 1200 gaccagcatg cctgtgtact gcagctgcgc gggagacttc gccctcacca tccacaccca 1260 ggtcttcatg gaacagatcg gaatattccg gaacattgcc cagcactacg gcatgtcgta 1320 cctcctggag accctggagt ggctgctgca gaagaaccca cagctgggcc attagccagc 1380 cccgggcccc gggtgcctct gcgtccgtgc caggcctcct gatgccaagg ccacatcccc 1440 gtgcttccag tgaccagacc actgaccacc ctgactgtcc aaacctgtga ccccaggcca 1500 gggaacgggg aggaaaccaa agaaaaccat tttcagggag ctcagacgtc acaggaggga 1560 gcgggagcag gatgtggccc tggcctcgcc agagcacctg aagaagcagg ccgtgagcga 1620 ggctgcgagt gccctgggcg ccgtttctca cgcagtgaat gcttttccag gcctctgttg 1680 cttcctgcac cacacctggt ggggtgggag cgtcctctag gtgcccctag ttctttgtcc 1740 tgcctcccag agggaggaaa agcccctggg ggcttctggc tccctgagat tgggctctga 1800 gacgagacgg gttcccaagg ccctggtggg gctggagtct cacctgtttg catggagaaa 1860 tgggctggcc ccacagcctc acaggagcag tttgtgggct ggtttcccca ggaatccaga 1920 ccctaacccg tgagaatctg gattttggct tgtgagccct gcttatttgg agccgggtct 1980 agagggaacc ctctatcagc ctcaggaaaa caagacctct gtgcacctca cttttggctc 2040 actgcagccc ttgtccttca cctccacaca ggaccagctg gaagcagaaa gaagaaaggc 2100 caatttcaca gggcaccaaa caagtatgaa atgtaaatca gaaatgcaga caccccagac 2160 gagagcctca caggagggag ggggccccac aggctcccca ggaggctcgt gtctttggcc 2220 cagagccagc cttagtttgt ccctgccatc tactgtctga ggccatcgct gctacacttt 2280 gtttttattt gtatttcata ctgaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa 2334 <210> 181 <211> 3001 <212> DNA <213> Homo sapiens <400> 181 agtgttacta atagaagggt cttatccttt gcccttaatt tggaaagcta aggtctaaga 60 cagggtccat tgggcttccc ttagtcttaa tggcagagcc agagaccact gtgtggcgag 120 ttttccatag tctattgtct ttaccactgt gggggtccgg cctggtccct ggcgactgtt 180 cagtgtgctg cctctgacct ccctgtggcc agaggtacct cacacagagt ctttctaacc 240 agggccactt ttcgatgtga ccaaaggtac atcacaggga tctccagcca gctctactga 300 gtatgatgtg tgaggcatca gcacttaggt gtcaggagct gtcggtctgc tgcagagggc 360 atggttgagg gtcaggagcc atcagtctgc ggagagcatg gttgagggca gctactcgca 420 ttacccacca gcggtggttc atgctgggca atgcttgctg tgtaccagga ggtgggccga 480 gcacttcgca ttctgcctct gtccccacat cagcccaggg acggggagcg gttattgtct 540 gtttttcaga taaggaaact gaggtcagag gggctgcctt tgtggtcata ccacaaatga 600 atggaaggga tcctgaagag catggtcgtg ggctgggtga aggagatcac ccagtaccac 660 aacatctatg cagacaacca ggtgatgcac ttctaccgct ggcttcggtc gccatcctct 720 ctgcttcatg accctgccct gcaccgcaca ctccacaaca tgatgaagaa gctcttcctg 780 cagctcatcg ctgagttcaa gcgcctgggg tcatcagtca tctacgccaa cttcaaccgc 840 atcatcctct gtacaaagaa gcgccgtgtg gaagatgcca tcgcttacgt ggagtacatc 900 accagcagca tccattcaaa ggagaccttc cattctctga caatttcttt ctctcgatgc 960 tgggaatttc ttctctggat ggatccatct aactatggcg gaatcaaagg aaaagtttca 1020 tctcgtattc actgtggact gcaagactcc cagaaagcag ggggagcaga ggatgagcag 1080 gaaaatgagg acgatgagga ggaaagagat ggggaggagg aggaagaggc ggaggaatcc 1140 aacgtggagg atttactgga aaacaactgg aacattttgc agtttttgcc acaggcagcc 1200 tcctgccaga actacttcct catgattgtt tcagcgtaca tcgtggccgt gtaccactgc 1260 atgaaggacg ggctgaggcg cagtgctcca gggagcaccc ccgtgaggag gaggggggcc 1320 agccagctct cccaggaggc cgagggggcg gtcggagccc ttcccggaat gatcaccttc 1380 tctcaggatt atgtcgcaaa tgagctcact cagagcttct tcaccatcac tcagaagatt 1440 cagaagaaag tcacaggctc tcggaactcc actgagctct cggagatgtt tcctgtcctc 1500 cccggttccc acttgctgct caataaccct gccctggagt tcatcaaata cgtgtgcaag 1560 gtgctgtccc tggacaccaa catcacaaac caggtgaata agctgaaccg agacctgctt 1620 cgcctggtgg atgtcggcga gttctccgag gaggcccagt tccgagaccc ctgccgctcc 1680 tacgtgcttc ctgaggtcat ctgccgcagc tgtaacttct gccgcgacct ggacctgtgt 1740 aaagactctt ccttctcaga ggatggggcg gtcctgcctc agtggctctg ctccaactgt 1800 caggcgccct acgactcctc tgccatcgag atgacgctgg tggaagttct acagaagaag 1860 ctgatggcct tcaccctgca ggacctggtc tgcctgaagt gccgcggggt gaaggagacc 1920 agcatgcctg tgtactgcag ctgcgcggga gacttcgccc tcaccatcca cacccaggtc 1980 ttcatggaac agatcggaat attccggaac attgcccagc actacggcat gtcgtacctc 2040 ctggagaccc tggagtggct gctgcagaag aacccacagc tgggccatta gccagcccca 2100 ggcctcctga tgccaaggcc acatccccgt gcttccagtg accagaccac tgaccaccct 2160 gactgtccaa acctgtgacc ccaggccagg gaacggggag gaaaccaaag aaaaccattt 2220 tcagggagct cagacgtcac aggagggagc gggagcagga tgtggccctg gcctcgccag 2280 agcacctgaa gaagcaggcc gtgagcgagg ctgcgagtgc cctgggcgcc gtttctcacg 2340 cagtgaacgc ttttccaggc ctctgttgct tcctgcacca cacctggtgg ggtgggagcg 2400 tcctctaggt gcccctagtt ctttgtcctg cctcccagag ggaggaaaag cccctggggg 2460 cttctggctc cctgagattg ggctctgaga cgagacgggt tcccaaggcc ctggtggggc 2520 tggagtctca cctgtttgca tggagaaatg ggctggcccc acagcctcac aggagcagtt 2580 tgtgggctgg tttccccggg aatccagacc ctaacccgtg agaatctgga ttttggcttg 2640 tgagccctgc ttatttggag ccgggtctag agggaaccct ctatcagcct caggaaaaca 2700 agacctctgt gcacctcact tttggctcac tgcagccctt gtccttcacc tccacacagg 2760 accagctgga agcagaaaga agaaaggcca atttcacagg gcaccaaaca agtatgaaat 2820 gtaaatcaga aatgcagaca ccccagacga gagcctcaca ggagggaggg ggccccacag 2880 gctccccagg aggctcgtgt ctttggccca gagccagcct tagtttgtcc ctgccatcta 2940 ctgtctgagg ccatcgctgc tacactttgt ttttatttgt atttcatact gaagtttctc 3000 t 3001 <210> 182 <211> 2098 <212> DNA <213> Homo sapiens <400> 182 ttctctcgat gctgggaatt tcttctctgg atggatccat ctaactatgg cggaatcaaa 60 ggaaaagttt catctcgtat tcactgtgga ctgcaagact cccagaaagc agggggagca 120 gaggatgagc aggaaaatga ggacgatgag gaggaaagag atggggagga ggaggaagag 180 gcggaggaat ccaacgtgga ggatttactg gaaaacaact ggaacatttt gcagtttttg 240 ccacaggcag cctcctgcca gaactacttc ctcatgattg tttcagcgta catcgtggcc 300 gtgtaccact gcatgaagga cgggctgagg cgcagtgctc cagggagcac ccccgtgagg 360 aggagggggg ccagccagct ctcccatgag gccgaggggg cggtcggagc ccttcccgga 420 atgatcacct tctctcagga ttatgtcgca aatgagctca ctcagagctt cttcaccatc 480 actcagaaga ttcagaagaa agtcacaggc tctcggaact ccactgagct ctcggagatg 540 tttcctgtcc tccccggttc ccacttgctg ctcaataacc ctgccctgga gttcatcaaa 600 tacgtgtgca aggtgctgtc cctggacacc aacatcacaa accaggtgaa taagctgaac 660 cgagacctgc ttcgcctggt ggatgtcggc gagttctccg aggaggccca gttccgagac 720 ccctgccgct cctacgtgct tcctgaggtc atctgccgca gctgtaactt ctgccgcgac 780 ctggacctgt gtaaagactc ttccttctca gaggatgggg cggtcctgcc tcagtggctc 840 tgctccaact gtcaggcgcc ctacgactcc tctgccatcg agatgacgct ggtggaagtt 900 ctacagaaga agctgatggc cttcaccctg caggacctgg tctgcctgaa gtgccgcggg 960 gtgaaggaga ccagcatgcc tgtgtactgc agctgcgcgg gagacttcgc cctcaccatc 1020 cacacccagg tcttcatgga acagatcgga atattccgga acattgccca gcactacggc 1080 atgtcgtacc tcctggagac cctggagtgg ctgctgcaga agaacccaca gctgggccat 1140 tagccagccc cgggccccgg gtgcctctgc gtccgtgcca ggcctcctga tgccaaggcc 1200 acatccccgt gcttccagtg accagaccac tgaccaccct gactgtccaa acctgtgacc 1260 ccaggccagg gaacggggag gaaaccaaag aaaaccattt tcagggagct cagacgtcac 1320 aggagggagc gggagcagga tgtggccctg gcctcgccag agcacctgaa gaagcaggcc 1380 gtgagcgagg ctgcgagtgc cctgggcgcc gtttctcacg cagtgaatgc ttttccaggc 1440 ctctgttgct tcctgcacca cacctggtgg ggtgggagcg tcctctaggt gcccctagtt 1500 ctttgtcctg cctcccagag ggaggaaaag cccctggggg cttctggctc cctgagattg 1560 ggctctgaga cgagacgggt tcccaaggcc ctggtggggc tggagtctca cctgtttgca 1620 tggagaaatg ggctggcccc acagcctcac aggagcagtt tgtgggctgg tttccccggg 1680 aatccagacc ctaacccgtg agaatctgga ttttggcttg tgagccctgc ttatttggag 1740 ccgggtctag agggaaccct ctatcagcct caggaaaaca agacctctgt gcacctcact 1800 tttggctcac tgcagccctt gtccttcacc tccacacagg accagctgga agcagaaaga 1860 agaaaggcca atttcacagg gcaccaaaca agtatgaaat gtaaatcaga aatgcagaca 1920 ccccagacga gagcctcaca ggagggaggg ggccccacag gctccccagg aggctcgtgt 1980 ctttggccca gagccagcct tagtttgtcc ctgccatcta ctgtctgagg ccatcgctgc 2040 tacactttgt ttttatttgt atttcatact gaagtttcaa aaaaaaaaaa aaaaaaaa 2098 <210> 183 <211> 1913 <212> DNA <213> Homo sapiens <400> 183 gaggaatcca acgtggagga tttactggaa aacaactgga acattttgca gtttttgcca 60 caggcagcct cctgctagaa ctacttcctc atgattgttt cagcgtacat cgtggccgtg 120 taccactgca tgaaggacgg gctgaggcgc agtgctccag ggagcacccc cgtgaggagg 180 aggggggcca gccagctctc ccaggaggcc gagggggcgg tcggagccct tcccggaatg 240 atcaccttct ctcaggatta tgtcgcaaat gagctcactc agagcttctt caccatcact 300 cagaagattc agaagaaagt cacaggctct cggaactcca ctgagctctc agagatgttt 360 cctgtcctcc ccggttccca cttgctgctc aataaccctg ccctggagtt catcaaatac 420 gtgtgcaagg tgctgtccct ggacaccaac atcacaacca ggtgaataag ctgaaccgag 480 acctgcttcg cctggtggat gtcggcgagt tctccgagga ggcccagttc cgagacccct 540 gccgctccta cgtgcttcct gaggtcatct gccgcagctg taacttctgc cgcgacctgg 600 acctgtgtaa agactcttcc ttctcagagg atggggcggt cctgcctcag tggctctgct 660 ccaactgtca ggcgccctac gactcctctg ccatcgagat gacgctggtg gaagttctac 720 agaagaagct gatggccttc accctgcagg acctggtctg cctgaagtgc cgcggggtga 780 aggagaccag catgcctgtg tactgcagct gcgcgggaga cttcgccctc accatccaca 840 cccaggtctt catggaacag atcggaatat tccggaacat tgcccagcac tacggcatgt 900 cgtacctcct ggagaccctg gagtggctgc tgcagaagaa cccacagctg ggccattagc 960 cagccccggg ccccgggtgc ctctgcgtcc gtgccaggcc tcctgatgcc aaggccacat 1020 ccccgtgctt ccagtgacca gaccactgac caccctgact gtccaaacct gtgaccccag 1080 gccagggaac ggggaggaaa ccaaagaaaa ccattttcag ggagctcaga cgtcacagga 1140 gggagcggga gcaggatgtg gccctggcct cgccagagca cctgaagaag caggccgtga 1200 gcgaggctgc gagtgccctg ggcgccgttt ctcacgcagt gaatgctttt ccaggcctct 1260 gttgcttcct gcaccacacc tggtggggtg ggagcgtcct ctaggtgccc ctagttcttt 1320 gtcctgcctc ccagagggag gaaaagcccc tgggggcttc tggctccctg agattgggct 1380 ctgagacgag acgggttccc aaggccctgg tggggctgga gtctcacctg tttgcatgga 1440 gaaatgggct ggccccacag cctcacagga gcagtttgtg ggctggtttc cccaggaatc 1500 cagaccctaa cccgtgagaa tctggatttt ggcttgtgag ccctgcttat ttggagccgg 1560 gtctagaggg aaccctctat cagcctcagg aaaacaagac ctctgtgcac ctcacttttg 1620 gctcactgca gcccttgtcc ttcacctcca cacaggacca gctggaagca gaaagaagaa 1680 aggccaattt cacagggcac caaacaagta tgaaatgtaa atcagaaatg cagacacccc 1740 agacgagagc ctcacaggag ggagggggcc ccacaggctc cccaggaggc tcgtgtcttt 1800 ggcccagagc cagccttagt ttgtccctgc catctactgt ctgaggccat cgctgctaca 1860 ctttgttttt atttgtattt catactgaag tttcaaaaaa aaaaaaaaaa aaa 1913 <210> 184 <211> 1604 <212> DNA <213> Homo sapiens <400> 184 ggtgaataag ctgaaccgag acctgcttcg cctggtggat gtcggcgagt tctccgagga 60 ggcccagttc cgagacccct gccgctccta cgtgcttcct gaggtcatct gccgcagctg 120 taacttctgc cgcgacctgg acctgtgtaa agactcttcc ttctcagagg atggggcggt 180 cctgcctcag tggctctgct ccaactgtca ggcgccctac gactcctctg ccatcgagat 240 gacgctggtg gaagttctac agaagaagct gatggccttc accctgcagg acctgaagga 300 ggcagacact cccaagtgtg aagagaagga aaggaggaag agggagttgc gcagctcggc 360 cacaggaagg tcttgccgag gggcatctga gcagaggctg ggggacgcgc caagctgccg 420 tgtggtggtg cacggcgttc aggcctgcag gatggaggga gtctgcctga agtgccgcgg 480 ggtgaaggag accagcatgc ctgtgtactg cagctgcgcg ggagacttcg ccctcaccat 540 ccacacccag gtcttcatgg aacagatcgg aatattccgg aacattgccc agcactacgg 600 catgtcgtac ctcctggaga ccctggagtg gctgctgcag aagaacccac agctgggcca 660 ttagccagcc ccgggccccg ggtgcctctg cgtccgtgcc aggcctcctg atgccaaggc 720 cacatccccg tgcttccagt gaccagacca ctgaccaccc tgactgtcca aacctgtgac 780 cccaggccag ggaacgggga ggaaaccaaa gaaaaccatt ttcagggagc tcagacgtca 840 caggagggag cgggagcagg atgtggccct ggcctcgcca gagcacctga agaagcaggc 900 cgtgagcgag gctgcgagtg ccctgggcgc cgtttctcac gcagtgaatg cttttccagg 960 cctctgttgc ttcctgcacc acacctggtg gggtgggagc gtcctctagg tgcccctagt 1020 tctttgtcct gcctcccaga gggaggaaaa gcccctgggg gcttctggct ccctgagatt 1080 gggctctgag acgagacggg ttcccaaggc cctggtgggg ctggagtctc acctgtttgc 1140 atggagaaat gggctggccc cacagcctca caggagcagt ttgtgggctg gtttccccgg 1200 gaatccagac cctaacccgt gagaatctgg attttggctt gtgagccctg cttatttgga 1260 gccgggtcta gagggaaccc tctatcagcc tcaggaaaac aagacctctg tgcacctcac 1320 ttttggctca ctgcagccct tgtccttcac ctccacacag gaccagctgg aagcagaaag 1380 aagaaaggcc aatttcacag ggcaccaaac aagtatgaaa tgtaaatcag aaatgcagac 1440 accccagacg agagcctcac aggagggagg gggccccaca ggctccccag gaggctcgtg 1500 tctttggccc agagccagcc ttagtttgtc cctgccatct actgtctgag gccatcgctg 1560 ctacactttg tttttatttg tatttcatac tgaagtttca aaaa 1604 <210> 185 <211> 2096 <212> DNA <213> Homo sapiens <400> 185 cggaatgttg tcctaggaag ggctcaagtg caggtgggag gccagagtgc gtgcagctgc 60 actcaggaga ctcgcccgtc accaggcgct tctcacagcc ccttcctctc ctgagatcct 120 gcccatggca ctgtggtctg gaggctgggc tggtgacctc tcgcactctt gctctgccta 180 ggatggggcg gtcctgcctc agtggctctg ctccaactgt caggcgccct acgactcctc 240 tgccatcgag atgacgctgg tggaagttct acagaagaag ctgatggcct tcaccctgca 300 ggacctggtg agtcgtgcat gccgcctgcc cgtgtgccct ggagtccaca ggggggtttc 360 tgtgcactcc cgggagccgg ggtgtgtgca ggtcctgagg cacgccctgg tgtcttccaa 420 ggggcctgcc ctgcagacca gtccatgccc tgagcctgat ggactgttct gtccacactg 480 gttgagcacc tgccttgggt caagagctgg ccttgtgggt gcttcgttct agcggaagga 540 ggcagacact cccaagtgtg aagagaagga aaggaggaag agggagttgc gcagctcggc 600 cacaggaagg tcttgccgag gggcatctga gcagaggctg ggggacgcgc caagctgccg 660 tgtggtggtg cacggcgttc aggcctgcag gatggaggga gtgagcaggg cctggaggag 720 gcctcaggac tgggcatctg gggtggaaca tccacagcga gggtgggtgt agggaaggcg 780 ctggcaccgt gggatgaggt cgtgcatttt actcataacc gagggctggc tgcacacagc 840 aggggctcga ggcttactga tgggcccacg aatgtgtctc gcgagcctgt gaagaagcag 900 caggcaggtc tggccagcgc gggagggctg gcgcccatcg gggctgctcc ctttcaggtc 960 tgcctgaagt gccgcggggt gaaggagacc agcatgcctg tgtactgcag ctgcgcggga 1020 gacttcgccc tcaccatcca cacccaggtc ttcatggaac agatcggaat attccggaac 1080 attgcccagc actacggcat gtcgtacctc ctggagaccc tggagtggct gctgcagaag 1140 aacccacagc tgggccatta gccagccccg ggccccgggt gcctctgcgt ccgtgccagg 1200 cctcctgatg ccaaggccac atccccgtgc ttccagtgac cagaccactg accaccctga 1260 ctgtccaaac ctgtgacccc aggccaggga acggggagga aaccaaagaa aaccattttc 1320 agggagctca gacgtcacag gagggagcgg gagcaggatg tggccctggc ctcgccagag 1380 cacctgaaga agcaggccgt gagcgaggct gcgagtgccc tgggcgccgt ttctcacgca 1440 gtgaatgctt ttccaggcct ctgttgcttc ctgcaccaca cctggtgggg tgggagcgtc 1500 ctctaggtgc ccctagttct ttgtcctgcc tcccagaggg aggaaaagcc cctgggggct 1560 tctggctccc tgagattggg ctctgagacg agacgggttc ccaaggccct ggtggggctg 1620 gagtctcacc tgtttgcatg gagaaatggg ctggccccac agcctcacag gagcagtttg 1680 tgggctggtc tccccgggaa tccagaccct aacccgtgag aatctggatt ttggcttgtg 1740 agccctgctt atttggagcc gggtctagag ggaaccctct atcagcctca ggaaaacaag 1800 acctctgtgc acctcacttt tggctcactg cagcccttgt ccttcacctc cacacaggac 1860 cagctggaag cagaaagaag aaaggccaat ttcacagggc accaaacaag tatgaaatgt 1920 aaatcagaaa tgcagacacc ccagacgaga gcctcacagg agggaggggg ccccacaggc 1980 tccccaggag gctcgtgtct ttggcccaga gccagcctta gtttgtccct gccatctact 2040 gtctgaggcc atcgctgcta cactttgttt ttatttgtat ttcatactga agtttc 2096 <210> 186 <211> 1954 <212> DNA <213> Homo sapiens <400> 186 acaccctctg ccgactccaa gacgctgcct cttcctgcgg gcgaggcgcg cggtctggta 60 ctcgtgcgtc ttttatcgcc tgagtttccc tccgccgact agcgcgcggg gcccggttct 120 ccatcgcgcg cacggcagcc tagcgcaatg aggcgggcac cctgcgttcg agataagttg 180 cgggagatag taggagcatc cacaaactgg agagaccatg tgaaggcaat ggaagaaagg 240 aaattacttc atagtttctt ggctaaatca caggatggac tgcctcctag gagaatgaag 300 gacagttata ttgaagttct cttgcctttg ggcagtgagc ctgaattacg agagaaatat 360 ttgactgttc aaaacaccgt aagatttggc aggattcttg aggatcttga cagcttggga 420 gttcttattt gttacatgca caacaaaatc cactccgcca agatgtctcc tttatcgata 480 gttacagccc tggtggataa gattgatatg tgtaagaaga gcttgagccc agaacaggac 540 attaagttca gtggccatgt tagctgggtc gggaagacat ccatggaagt gaagatgcaa 600 atgttccagt tacatggtga tgaattttgt cctgttttgg atgcaacatt tgtaatggtg 660 gctcgtgatt ctgaaaataa agggccggca tttgtaaatc cactcatccc tgaaagccca 720 gaggaagagg agctctttag acaaggggaa ttgaacaagg ggagaagaat tgccttcagc 780 tccacgtcgt tactgaaaat ggcccccagc gctgaggaga ggaccaccat acatgagatg 840 tttctcagca cactggatcc aaagactata agttttcgga gtcgagtttt accctctaat 900 gcagtgtgga tggagaattc aaaactgaag agtttggaaa tttgccaccc tcaggagcgg 960 aacattttca atcggatctt tggtggtttc cttatgagga aggcatatga acttgcgtgg 1020 gctactgctt gtagctttgg tggttctcga ccgtttgtgg tagcagtaga tgacatcatg 1080 tttcagaaac ctgttgaggt tggctcattg ctctttcttt cttcacaggt atgctttact 1140 cagaataatt atattcaagt cagagtacac agtgaagtgg cctccctgca ggagaagcag 1200 catacaacca ccaatgtctt tcatttcacg ttcatgtcgg aaaaagaagt gccattggtt 1260 ttcccaaaaa catatggaga gtccatgttg tacttagatg ggcagcggca tttcaactcc 1320 atgagtggcc cagcgacctt gagaaaggac taccttgtgg agccctaaga acaccacatt 1380 tgttgaaaac tagcactcta cccacagtga cgtggtatct gatgaagacc tgatcgagtg 1440 tattgatttt agtattgctt cgtgtcctcc acacaggagg aggatgtatt cagcctttag 1500 gatgatcaga aaagcagaaa gagagagtgg ccggatgggg ctgaggggag aaagaattat 1560 taaacaataa atactttcaa gacaatttta attgtgaacc taccatgttg cctcccatct 1620 tctgaaaaaa caaaaaaatt ataggcatga gccactgcac ccggccggtg gaaagcattt 1680 ttaacaaaaa atttttaggc caggcacagt ggtggctcat gcctgtaatc ccagcacttt 1740 gggagactga gatgggagga tcgcttgaga ccagcctggg gaacatagtg agaccctttc 1800 tctacaaaaa gttaaaaaat tatctgagca tggtggtgtg cacctgtagt cccagttagg 1860 aggctgaggt gagtggattg cttgagtccg ggagtttgag tctgcagtga gctatgatca 1920 tgccactgca ctccagtctg ggtgacagca agac 1954 <210> 187 <211> 1954 <212> DNA <213> Homo sapiens <400> 187 acaccctctg ccgactccaa gacgctgcct cttcctgcgg gcgaggcgcg cggtctggta 60 ctcgtgcgtc ttttatcgcc tgagtttccc tccgccgact agcgcgcggg gcccggttct 120 ccatcgcgcg cacggcagcc tagcgcaatg aggcgggcac cctgcgttcg agataagttg 180 cgggagatag taggagcatc cacaaactgg agagaccatg tgaaggcaat ggaagaaagg 240 aaattacttc atagtttctt ggctaaatca caggatggac tgcctcctag gagaatgaag 300 gacagttata ttgaagttct cttgcctttg ggcagtgagc ctgaattacg agagaaatat 360 ttgactgttc aaaacaccgt aagatttggc aggattcttg aggatcttga cagcttggga 420 gttcttattt gttacatgca caacaaaatc cactccgcca agatgtctcc tttatcgata 480 gttacagccc tggtggataa gattgatatg tgtaagaaga gcttgagccc agaacaggac 540 attaagttca gtggccatgt tagctgggtc gggaagacat ccatggaagt gaagatgcaa 600 atgttccagt tacatggtga tgaattttgt cctgttttgg atgcaacatt tgtaatggtg 660 gctcgtgatt ctgaaaataa agggccggca tttgtaaatc cactcatccc tgaaagccca 720 gaggaagagg agctctttag acaaggggaa ttgaacaagg ggagaagaat tgccttcagc 780 tccacgtcgt tactgaaaat ggcccccagc gctgaggaga ggaccaccat acatgagatg 840 tttctcagca cactggatcc aaagactata agttttcgga gtcgagtttt accctctaat 900 gcagtgtgga tggagaattc aaaactgaag agtttggaaa tttgccaccc tcaggagcgg 960 aacattttca atcggatctt tggtggtttc cttatgagga aggcatatga acttgcgtgg 1020 gctactgctt gtagctttgg tggttctcga ccgtttgtgg tagcagtaga tgacatcatg 1080 tttcagaaac ctgttgaggt tggctcattg ctctttcttt cttcacaggt atgctttact 1140 cagaataatt atattcaagt cagagtacac agtgaagtgg cctccctgca ggagaagcag 1200 catacaacca ccaatgtctt tcatttcacg ttcatgtcgg aaaaagaagt gccattggtt 1260 ttcccaaaaa catatggaga gtccatgttg tacttagatg ggcagcggca tttcaactcc 1320 atgagtggcc cagcgacctt gagaaaggac taccttgtgg agccctaaga acaccacatt 1380 tgttgaaaac tagcactcta cccacagtga cgtggtatct gatgaagacc tgatcgagtg 1440 tattgatttt agtattgctt cgtgtcctcc acacaggagg aggatgtatt cagcctttag 1500 gatgatcaga aaagcagaaa gagagagtgg ccggatgggg ctgaggggag aaagaattat 1560 taaacaataa atactttcaa gacaatttta attgtgaacc taccatgttg cctcccatct 1620 tctgaaaaaa caaaaaaatt ataggcatga gccactgcac ccggccggtg gaaagcattt 1680 ttaacaaaaa atttttaggc caggcacagt ggtggctcat gcctgtaatc ccagcacttt 1740 gggagactga gatgggagga tcgcttgaga ccagcctggg gaacatagtg agaccctttc 1800 tctacaaaaa gttaaaaaat tatctgagca tggtggtgtg cacctgtagt cccagttagg 1860 aggctgaggt gagtggattg cttgagtccg ggagtttgag tctgcagtga gctatgatca 1920 tgccactgca ctccagtctg ggtgacagca agac 1954 <210> 188 <211> 2185 <212> DNA <213> Homo sapiens <400> 188 agcggcgcag ggcaccatgg gaaacggacg gaagctccat tgagccaaat aagttggcca 60 cgtggggcgg aacggaaacc tcgcagggtc agaccgtagc gacgcgggaa gtccggacgc 120 agtagctccc tgaagcggag gcgaagggga gtttaagccc cagcggcggc aatggcggag 180 aggcccgagg acctaaacct gcccaatgcc gtgatcacca ggatcatcaa ggaggcgctc 240 ccggacggtg tcaacatctc caaggaggcc cggagcgcca tctcccgcgc cgccagcgtc 300 ttcgtgctgt acgccacatc ctgtgctaac aactttgcaa tgaaaggaaa gcggaagacg 360 ctgaatgcca gtgatgtgct ctcagccatg gaagagatgg agttccagcg gttcgttatc 420 ccattgaaag aagctctgga agcatatagg cgggagcaga aaggcaagaa ggaggcctca 480 gagcaaaaga agaaggacaa agacaaaaaa acagactcgg aagagcaaga caagagcagg 540 gatgaggaca atgatgaaga cgaagaaagg ctggaagaag aagaacagaa tgaagaggaa 600 gaagtagaca actgaaaagg gcgggagact gtggcacctt ggaaggtacc acttgaaatg 660 agacgtgcta cgtgtttctg tgaagctttt ccatgctggg cagagtagtc tcaggcaaaa 720 gtgcctgaaa agatcagaat aaaaactgac tagaaatacc gtcaaaacca gcacttacca 780 aactcagagc atctgagtag cagaatcctg ttttgcttca tcaatctgaa ggttatggcc 840 ttttgacaag agggattctg aacgactaaa ttagtcagtt tgctcgcttt tgtttactta 900 aatgtatggt tagatggttt ttgatctgca gtcttcccta gtcccccaaa taagtaataa 960 taacttccat gctgcctgct gtgttccaga tcacagaggc agccaaggct caggaaaaac 1020 tggggctttg cttatggtca gcctatgttt gattgcacag tctttgacaa tagtagctta 1080 ctaagactgc tcagaatgag taagctttag gaaactacta aaatgctgtg ggagaataac 1140 aaaatccgtt ctctctcttc acttgacaga agcattaact gaattttgtt tttcatagac 1200 ccacttggcc caaaaccttt ctatattgcc tgtagatgat cggcctgctg gtgtggtagt 1260 aatctgatca cagatattct taaatcagca gtgtggaatg gtattagtca aacatggtgc 1320 cagtgtcttt tacaaaaaca gatggcatag tgtcagatgt accttactct ctgctactgt 1380 acagctttag gatttgtcat cacctcccgg aaggtgtaaa accccaggct tcctcttctt 1440 gtagtccatc tcccagactt gtgactatgg cttttcattc ttcaattcat gacgagtgcc 1500 aaacttgatt ttctctaggc acagctttct ccctctgtgc ctcctgcttc ctttctctct 1560 cctgcctctc ctctgctccc catcccactt tctcatctgc ctccttttct cacttctgtc 1620 agtctgtaag ctttgataac ctgcttaata ctccaaagtg tgagttcctc tgatctcttg 1680 attccttagt tctaatctca cgttttgttt ttaagagatg gagtctctca ctctgtggcc 1740 caggctggag tgcagtggca tgatcatagc tcattgcatc cttgaaatcc tgggctcagg 1800 tgatcctccc gcctgagcct cctgagtatc tgggactaca gatgcgtgcc accaagcctg 1860 gctaattttg tctcatgtct tctaaaaatt attttgtgaa gccccttcac aaaaaacctt 1920 aagggaaatc tgatggtgct caggaatcta actctcccta aaccatcctc tttaactgct 1980 tctaaaatat ctctgttggc ctttcttagc ctttttctgt ttccattcag tgctccaagc 2040 gctttttgtt tctaagttga gtgcttgggg tttgacaggt agtgacgtgt agtttgacac 2100 tgttaacttg ttaaatacag tgaaaagttt gtgagtgaag aatgctgaga agattgtaat 2160 gctttgtaca aataaaagtc ttgtt 2185 <210> 189 <211> 2185 <212> DNA <213> Homo sapiens <400> 189 agcggcgcag ggcaccatgg gaaacggacg gaagctccat tgagccaaat aagttggcca 60 cgtggggcgg aacggaaacc tcgcagggtc agaccgtagc gacgcgggaa gtccggacgc 120 agtagctccc tgaagcggag gcgaagggga gtttaagccc cagcggcggc aatggcggag 180 aggcccgagg acctaaacct gcccaatgcc gtgatcacca ggatcatcaa ggaggcgctc 240 ccggacggtg tcaacatctc caaggaggcc cggagcgcca tctcccgcgc cgccagcgtc 300 ttcgtgctgt acgccacatc ctgtgctaac aactttgcaa tgaaaggaaa gcggaagacg 360 ctgaatgcca gtgatgtgct ctcagccatg gaagagatgg agttccagcg gttcgttatc 420 ccattgaaag aagctctgga agcatatagg cgggagcaga aaggcaagaa ggaggcctca 480 gagcaaaaga agaaggacaa agacaaaaaa acagactcgg aagagcaaga caagagcagg 540 gatgaggaca atgatgaaga cgaagaaagg ctggaagaag aagaacagaa tgaagaggaa 600 gaagtagaca actgaaaagg gcgggagact gtggcacctt ggaaggtacc acttgaaatg 660 agacgtgcta cgtgtttctg tgaagctttt ccatgctggg cagagtagtc tcaggcaaaa 720 gtgcctgaaa agatcagaat aaaaactgac tagaaatacc gtcaaaacca gcacttacca 780 aactcagagc atctgagtag cagaatcctg ttttgcttca tcaatctgaa ggttatggcc 840 ttttgacaag agggattctg aacgactaaa ttagtcagtt tgctcgcttt tgtttactta 900 aatgtatggt tagatggttt ttgatctgca gtcttcccta gtcccccaaa taagtaataa 960 taacttccat gctgcctgct gtgttccaga tcacagaggc agccaaggct caggaaaaac 1020 tggggctttg cttatggtca gcctatgttt gattgcacag tctttgacaa tagtagctta 1080 ctaagactgc tcagaatgag taagctttag gaaactacta aaatgctgtg ggagaataac 1140 aaaatccgtt ctctctcttc acttgacaga agcattaact gaattttgtt tttcatagac 1200 ccacttggcc caaaaccttt ctatattgcc tgtagatgat cggcctgctg gtgtggtagt 1260 aatctgatca cagatattct taaatcagca gtgtggaatg gtattagtca aacatggtgc 1320 cagtgtcttt tacaaaaaca gatggcatag tgtcagatgt accttactct ctgctactgt 1380 acagctttag gatttgtcat cacctcccgg aaggtgtaaa accccaggct tcctcttctt 1440 gtagtccatc tcccagactt gtgactatgg cttttcattc ttcaattcat gacgagtgcc 1500 aaacttgatt ttctctaggc acagctttct ccctctgtgc ctcctgcttc ctttctctct 1560 cctgcctctc ctctgctccc catcccactt tctcatctgc ctccttttct cacttctgtc 1620 agtctgtaag ctttgataac ctgcttaata ctccaaagtg tgagttcctc tgatctcttg 1680 attccttagt tctaatctca cgttttgttt ttaagagatg gagtctctca ctctgtggcc 1740 caggctggag tgcagtggca tgatcatagc tcattgcatc cttgaaatcc tgggctcagg 1800 tgatcctccc gcctgagcct cctgagtatc tgggactaca gatgcgtgcc accaagcctg 1860 gctaattttg tctcatgtct tctaaaaatt attttgtgaa gccccttcac aaaaaacctt 1920 aagggaaatc tgatggtgct caggaatcta actctcccta aaccatcctc tttaactgct 1980 tctaaaatat ctctgttggc ctttcttagc ctttttctgt ttccattcag tgctccaagc 2040 gctttttgtt tctaagttga gtgcttgggg tttgacaggt agtgacgtgt agtttgacac 2100 tgttaacttg ttaaatacag tgaaaagttt gtgagtgaag aatgctgaga agattgtaat 2160 gctttgtaca aataaaagtc ttgtt 2185 <210> 190 <211> 2106 <212> DNA <213> Homo sapiens <400> 190 gacgcgggaa gtccggacgc agtagctccc tgaagcggag gcgaagggga gtttaagccc 60 cagcggcggc aatggcggag aggcccgagg acctaaacct gcccaatgcc gtgatcacca 120 ggatcatcaa ggaggcgctc ccggacggtg tcaacatctc caaggaggcc cggagcgcca 180 tctcccgcgc cgccagcgtc ttcgtgctgt acgccacatc ctgtgctaac aactttgcaa 240 tgaaaggaaa gcggaagacg ctgaatgcca gtgatgtgct ctcagccatg gaagagatgg 300 agttccagcg gttcgttacc ccattgaaag aagctctgga agcatatagg cgggagcaga 360 aaggcaagaa ggaggcctca gagcaaaaga agaaggacaa agacaaaaaa acagactcgg 420 aagagcaaga caagagcagg gatgaggaca atgatgaaga cgaagaaagg ctggaagaag 480 aagaacagaa tgaagaggaa gaagtagaca actgaaaagg gcgggagact gtggcacctt 540 ggaaggtacc acttgaaatg agacgtgcta cgtgtttctg tgaagctttt ccatgctggg 600 cagagtagtc tcaggcaaaa gtgcctgaaa agatcagaat aaaaactgac tagaaatacc 660 gtcaaaacca gcacttacca aactcagagc atctgagtag cagaatcctg ttttgcttca 720 tcaatctgaa ggttatggcc ttttgacaag agggattctg aacgactaaa ttagtcagtt 780 tgctcgcttt tgtttactta aatgtatggt tagatggttt ttgatctgca gtcttcccta 840 gtcccccaaa taagtaataa taacttccat gctgcctgct gtgttccaga tcacagaggc 900 agccaaggct caggaaaaac tggggctttg cttatggtca gcctatgttt gattgcacag 960 tctttgacaa tagtagctta ctaagactgc tcagaatgag taagctttag gaaactacta 1020 aaatgctgtg ggagaataac aaaatccgtt ctctctcttc acttgacaga agcattaact 1080 gaattttgtt tttcatagac ccacttggcc caaaaccttt ctatattgcc tgtagatgat 1140 cggcctgctg gtgtggtagt aatctgatca cagatattct taaatcagca gtgtggaatg 1200 gtattagtca aacatggtgc cagtgtcttt tacaaaaaca gatggcatag tgtcagatgt 1260 accttactct ctgctactgt acagctttag gatttgtcat cacctcccgg aaggtgtaaa 1320 accccaggct tcctcttctt gtagtccatc tcccagactt gtgactatgg cttttcattc 1380 ttcaattcat gacgagtgcc aaacttgatt ttctctaggc acagctttct ccctctgtgc 1440 ctcctgcttc ctttctctcc tgcctctcct ctgctcccca tcccactttc tcatctgcct 1500 ccttttctca cttctgtcag tctgtaagct ttgataacct gcttaatact ccaaagtgtg 1560 agttcctctg atctcttgat tccttagttc taatctcacg ttttgttttt aagagatgga 1620 gtctctcact ctgtggccca ggctggagtg cagtggcatg atcatagctc attgcatcct 1680 tgaaatcctg ggctcaggtg atcctcccgc ctgagcctcc tgagtatctg ggactacaga 1740 tgcgtgccac caagcctggc taattttgtc tcatgtcttc taaaaattat tttgtgaagc 1800 cccttcacaa aaaaccttaa gggaaatctg atggtgctca ggaatctaac tctccctaaa 1860 ccatcctctt taactgcttc taaaatatct ctgttggcct ttcttagcct ttttctgttt 1920 ccattcagtg ctccaagcgc tttttgtttc taagttgagt gcttggggtt tgacaggtag 1980 tgacgtgtag tttgacactg ttaacttgtt aaatacagtg aaaagtttgt gagtgaagaa 2040 tgctgagaag attgtaatgc tttgtacaaa taaaagtctt gttaaaaaaa aaaaaaaaaa 2100 aaaaaa 2106 <210> 191 <211> 2106 <212> DNA <213> Homo sapiens <400> 191 gacgcgggaa gtccggacgc agtagctccc tgaagcggag gcgaagggga gtttaagccc 60 cagcggcggc aatggcggag aggcccgagg acctaaacct gcccaatgcc gtgatcacca 120 ggatcatcaa ggaggcgctc ccggacggtg tcaacatctc caaggaggcc cggagcgcca 180 tctcccgcgc cgccagcgtc ttcgtgctgt acgccacatc ctgtgctaac aactttgcaa 240 tgaaaggaaa gcggaagacg ctgaatgcca gtgatgtgct ctcagccatg gaagagatgg 300 agttccagcg gttcgttacc ccattgaaag aagctctgga agcatatagg cgggagcaga 360 aaggcaagaa ggaggcctca gagcaaaaga agaaggacaa agacaaaaaa acagactcgg 420 aagagcaaga caagagcagg gatgaggaca atgatgaaga cgaagaaagg ctggaagaag 480 aagaacagaa tgaagaggaa gaagtagaca actgaaaagg gcgggagact gtggcacctt 540 ggaaggtacc acttgaaatg agacgtgcta cgtgtttctg tgaagctttt ccatgctggg 600 cagagtagtc tcaggcaaaa gtgcctgaaa agatcagaat aaaaactgac tagaaatacc 660 gtcaaaacca gcacttacca aactcagagc atctgagtag cagaatcctg ttttgcttca 720 tcaatctgaa ggttatggcc ttttgacaag agggattctg aacgactaaa ttagtcagtt 780 tgctcgcttt tgtttactta aatgtatggt tagatggttt ttgatctgca gtcttcccta 840 gtcccccaaa taagtaataa taacttccat gctgcctgct gtgttccaga tcacagaggc 900 agccaaggct caggaaaaac tggggctttg cttatggtca gcctatgttt gattgcacag 960 tctttgacaa tagtagctta ctaagactgc tcagaatgag taagctttag gaaactacta 1020 aaatgctgtg ggagaataac aaaatccgtt ctctctcttc acttgacaga agcattaact 1080 gaattttgtt tttcatagac ccacttggcc caaaaccttt ctatattgcc tgtagatgat 1140 cggcctgctg gtgtggtagt aatctgatca cagatattct taaatcagca gtgtggaatg 1200 gtattagtca aacatggtgc cagtgtcttt tacaaaaaca gatggcatag tgtcagatgt 1260 accttactct ctgctactgt acagctttag gatttgtcat cacctcccgg aaggtgtaaa 1320 accccaggct tcctcttctt gtagtccatc tcccagactt gtgactatgg cttttcattc 1380 ttcaattcat gacgagtgcc aaacttgatt ttctctaggc acagctttct ccctctgtgc 1440 ctcctgcttc ctttctctcc tgcctctcct ctgctcccca tcccactttc tcatctgcct 1500 ccttttctca cttctgtcag tctgtaagct ttgataacct gcttaatact ccaaagtgtg 1560 agttcctctg atctcttgat tccttagttc taatctcacg ttttgttttt aagagatgga 1620 gtctctcact ctgtggccca ggctggagtg cagtggcatg atcatagctc attgcatcct 1680 tgaaatcctg ggctcaggtg atcctcccgc ctgagcctcc tgagtatctg ggactacaga 1740 tgcgtgccac caagcctggc taattttgtc tcatgtcttc taaaaattat tttgtgaagc 1800 cccttcacaa aaaaccttaa gggaaatctg atggtgctca ggaatctaac tctccctaaa 1860 ccatcctctt taactgcttc taaaatatct ctgttggcct ttcttagcct ttttctgttt 1920 ccattcagtg ctccaagcgc tttttgtttc taagttgagt gcttggggtt tgacaggtag 1980 tgacgtgtag tttgacactg ttaacttgtt aaatacagtg aaaagtttgt gagtgaagaa 2040 tgctgagaag attgtaatgc tttgtacaaa taaaagtctt gttaaaaaaa aaaaaaaaaa 2100 aaaaaa 2106 <210> 192 <211> 1608 <212> DNA <213> Homo sapiens <400> 192 attgcagggt cagaccgtag cgacgcggga agtccggacg cagtagctcc ctgaagcgga 60 ggcgaagggg agtttaagcc ccagcggcgg caatggcgga gaggcccgag gacctaaacc 120 tgcccaatgc cgtgatcacc aggatcatca aggaggcgct cccggacggt gtcaacatct 180 ccaaggaggc ccggagcgcc atctcccgcg ccgccagcgt cttcgtgctg tacgccacat 240 cctgtgctaa caactttgca atgaaaggaa agcggaagac gctgaatgcc agtgatgtgc 300 tctcagccat ggaagagatg gagttccagc ggttcgttac cccattgaaa gaagctctgg 360 aagcatatag gcgggagcag aaaggcaaga aggaggcctc agagcaaaag aagaaggaca 420 aagacaaaaa aacagactcg gaagagcaag acaagagcag ggatgaggac aatgatgaag 480 acgaagaaag gctggaagaa gaagaacaga atgaagagga agaagtagac aactgaaaag 540 ggcgggagac tgtggcacct tggaaggtac cacttgaaat gagacgtgct acgtgtttct 600 gtgaagcttt tccatgctgg gcagagtagt ctcaggcaaa agtgcctgaa aagatcagaa 660 taaaaactga ctagaaatac cgtcaaaacc agcacttacc aaactcagag catctgagta 720 gcagaatcct gttttgcttc atcaatctga aggttatggc cttttgacaa gagggattct 780 gaacgactaa attagtcagt ttgctcgctt ttgtttactt aaatgtatgg ttagatggtt 840 tttgatctgc agtcttccct agtcccccaa ataagtaata ataacttcca tgctgcctgc 900 tgtgttccag atcacagagg cagccaaggc tcaggaaaaa ctggggcttt gcttatggtc 960 agcctatgtt tgattgcaca gtctttgaca atagtagctt actaagactg ctcagaatga 1020 gtaagcttta ggaaactact aaaatgctgt gggagaataa caaaatccgt tctctctctt 1080 cacttgacag aagcattaac tgaattttgt ttttcataga cccacttggc ccaaaacctt 1140 tctatattgc ctgtagatga tcggcctgct ggtgtggtag taatctgatc acagatattc 1200 ttaaatcagc agtgtggaat ggtattagtc aaacatggtg ccagtgtctt ttacaaaaac 1260 agatggcata gtgtcagatg taccttactc tctgctactg tacagcttta ggatttgtca 1320 tcacctcccg gaaggtgtaa aaccccaggc ttcctcttct tgtagtccat ctcccagact 1380 tgtgactatg gcttttcatt cttcaattca tgacgagtgc caaacttgat tttctctagg 1440 cacagctttc tccctctgtg cctcctgctt cctttctctc tcctgcctct cctctgctcc 1500 ccatcccact ttctcatctg cctccttttc tcacttctgt cagtctgtaa gctttgataa 1560 cctgcttaat actccagcct gggcaacaga gcgagactct gtctgaac 1608 <210> 193 <211> 444 <212> DNA <213> Homo sapiens <400> 193 atggcggaga ggcccgagga cctaaacctg cccaatgccg tgatcaccag gatcatcaag 60 gaggcgctcc cggacggtgt caacatctcc aaggaggccc ggagcgccat ctcccgcgcc 120 gccagcgtct tcgtgctgta cgccacatcc tgtgctaaca actttgcaat gaaaggaaag 180 cggaagacgc tgaatgccag tgatgtgctc tcagccatgg aagagatgga gttccagcgg 240 ttcgttaccc cattgaaaga agctctggaa gcatataggc gggagcagaa aggcaagaag 300 gaggcctcag agcaaaagaa gaaggacaaa gacaaaaaaa cagactcgga agagcaagac 360 aagagcaggg atgaggacaa tgatgaagac gaagaaaggc tggaagaaga agaacagaat 420 gaagaggaag aagtagacaa ctga 444 <210> 194 <211> 2095 <212> DNA <213> Homo sapiens <400> 194 agaccgtagc gacgcgggaa gtccggacgc agtagctccc tgaagcggag gcgaagggga 60 gtttaagccc cagcggcggc aatggcggag aggcccgagg acctaaacct gcccaatgcc 120 gtgatcacca ggatcatcaa ggaggcgctc ccggacggtg tcaacatctc caaggaggcc 180 cggagcgcca tctcccgcgc cgccagcgtc ttcgtgctgt acgccacatc ctgtgctaac 240 aactttgcaa tgaatggaaa gcggaagacg ctgaatgcca gtgatgtgct ctcagccatg 300 gaagagatgg agttccagcg gttcgttacc ccattgaaag aagctctgga agcatatagg 360 cgggagcaga aaggcaagaa ggaggcctca gagcaaaaga agaaggacaa agacaaaaaa 420 acagactcgg aagagcaaga caagagcagg gatgaggaca atgatgaaga cgaagaaagg 480 ctggaagaag aagaacagaa tgaagaggaa gaagtagaca actgaaaagg gcgggagact 540 gtggcacctt ggaaggtacc acttgaaatg agacgtgcta cgtgtttctg tgaagctttt 600 ccatgctggg cagagtagtc tcaggcaaaa gtgcctgaaa agatcagaat aaaaactgac 660 tagaaatacc gtcaaaacca gcacttacca aactcagagc atctgagtag cagaatcctg 720 ttttgcttca tcaatctgaa ggttatggcc ttttgacaag agggattctg aacgactaaa 780 ttagtcagtt tgctcgcttt tgtttactta aatgtatggt tagatggttt ttgatctgca 840 gtcttcccta gtcccccaaa taagtaataa taacttccat gctgcctgct gtgttccaga 900 tcacagaggc agccaaggct caggaaaaac tggggttttg cttatggtca gcctatgttt 960 gattgcacag tctttgacaa tagtagctta ctaagactgc tcagaatgag taagctttag 1020 gaaactacta aaatgctgtg ggagaataac aaaatccgtt ctctctcttc acttgacaga 1080 agcattaact gaattttgtt tttcatagac ccacttggcc caaaaccttt ctatattgcc 1140 tgtagatgat cggcctgctg gtgtggtagt aatctgatca cagatattct taaatcagca 1200 gtgtggaatg gtattagtca aacatggtgc cagtgtcttt tacaaaaaca gatggcatag 1260 tgtcagatgt accttactct ctgctactgt acagctttag gatttgtcat cacctcccgg 1320 aaggtgtaaa accccaggct tcctcttctt gtagtccatc tcccagactt gtgactatgg 1380 cttttcattc ttcaattcat gacgagtgcc aaacttgatt ttctctaggc acagctttct 1440 ccctctgtgc ctcctgcttc ctttctctct cctgcctctc ctctgctccc catcccactt 1500 tctcatctgc ctccttttct cacttctgtc agtctgtaag ctttgataac ctgcttaata 1560 ctccaaagtg tgagttcctc tgatctcttg attccttagt tctaatctca cgttttgttt 1620 ttaagagatg gagtctctca ctctgtggcc caggctggag tgcagtggca tgatcatagc 1680 tcattgcatc cttgaaatcc tgggctcagg tgatcctccc gcctgagcct cctgagtatc 1740 tgggactaca gatgcgtgcc accaagcctg gctaattttg tctcatgtct tctaaaaatt 1800 attttgtgaa gccccttcac aaaaaacctt aagggaaatc tgatggtgct caggaatcta 1860 actctcccta aaccatcctc tttaactgct tctaaaatat ctctgttggc ctttcttagc 1920 ctttttctgt ttccattcag tgctccaagc gctttttgtt tctaagttga gtgcttgggg 1980 tttgacaggt agtgacgtgt agtttgacac tgttaacttg ttaaatacag tgaaaagttt 2040 gtgagtgaag aatgctgaga agattgtaat gctttgtaca aataaaagtc ttgtt 2095 <210> 195 <211> 1857 <212> DNA <213> Homo sapiens <400> 195 gtcagaccgt agcgacgcgg gaagtccgga cgcagtagct ccctgaagcg gaggcgaagg 60 ggagtttaag ccccagcggc ggcaatggcg gagaggcccg aggacctaaa cctgcccaat 120 gccgtgatca ccaggatcat caaggaggcg ctcccggacg gtgtcaacat ctccaaggag 180 gcccggagcg ccatctcccg cgccgccagc gtcttcgtgc tgtacgccac atcctgtgct 240 aacaactttg caatgaaagg aaagcggaag acgctgaatg ccagtgatgt gctctcagcc 300 atggaagaga tggagttcca gcggttcgtt accccattga aagaagaagg acaaagacaa 360 aaaaacagac tcggaagagc aagacaagag cagggatgag gacaatgatg aagacgaaga 420 aaggctggaa gaagaagaac agaatgaaga ggaagaagta gacaactgaa aagggcggga 480 gactgtggca ccttggaagg taccacttga aatgagacgt gctacgtgtt tctgtgaagc 540 ttttccatgc tgggcagagt agtctcaggc aaaagtgcct gaaaagatca gaataaaaac 600 tgactagaaa taccgtcaaa accagcactt accaaactca gagcatctga gtagcagaat 660 cctgttttgc ttcatcaatc tgaaggttat ggccttttga caagagggat tctgaacgac 720 taaattagtc agtttgctcg cttttgttta cttaaatgta tggttagatg gtttttgatc 780 tgcagtcttc cctagtcccc caaataagta ataataactt ccatgctgcc tgctgtgttc 840 cagatcacag aggcagccaa ggctcaggaa aaactggggc tttgcttatg gtcagcctat 900 gtttgattgc acagtctttg acaatagtag cttactaaga ctgctcagaa tgagtaagct 960 ttaggaaact actaaaatgc tgtgggagaa taacaaaatc cgttctctct cttcacttga 1020 cagaagcatt aactgaattt tgtttttcat agacccactt ggcccaaaac ctttctatat 1080 tgcctgtaga tgatcggcct gctggtgtgg tagtaatctg atcacagata ttcttaaatc 1140 agcagtgtgg aatggtatta gtcaaacatg gtgccagtgt cttttacaaa aacagatggc 1200 atagtgtcag atgtacctta ctctctgcta ctgtacagct ttaggatttg tcatcacctc 1260 ccggaaggtg taaaacccca ggcttcctct tcttgtagtc catctcccag acttgtgact 1320 atggcttttc attcttcaat tcatgacgag tgccaaactt gattttctct aggcacagct 1380 ttctccctct gtgcctcctg cttcctttct ctctcctgcc tctcctctgc tccccatccc 1440 actttctcat ctgcctcctt ttctcacttc tgtcagtctg taagctttga taacctgctt 1500 aatactccaa agtgtgagtt cctctgatct cttgattcct tagttctaaa aattattttg 1560 tgaagcccct tcacaaaaaa ccttaaggga aatctgatgg tgctcaggaa tctaactctc 1620 cctaaaccat cctctttaac tgcttctaaa atatctctgt tggcctttct tagccttttt 1680 ctgtttccat tcagtgctcc aagcgctttt tgtttctaag ttgagtgctt ggggtttgac 1740 aggtagtgac gtgtagtttg acactgttaa cttgttaaat acagtgaaaa gtttgtgagt 1800 gaagaatgct gagaagattg taatgctttg tacaaataaa agtcttgtta aaaaatg 1857 <210> 196 <211> 2390 <212> DNA <213> Homo sapiens <400> 196 gtagctccct gaagcggagg cgaaggggag tttaagcccc agcggcggca atggcggaga 60 ggcccgagga cctaaacctg cccaatgccg tgatcaccag gatcatcaag gaggcgctcc 120 cggacggtgt caacatctcc aaggaggccc ggagcgccat ctcccgcgcc gccagcgtct 180 tcgtgctgta cgccacatcc tggtgagcgg gacagaggca taagggaggc gcggggatac 240 ctggctggga gttgctggct gggagcctac aaaccccaac gattgtgttc tccctcggtg 300 gggacatgtt cacagtcctc tgccagtttt tacaagttct gaagcaaaat aacacaacaa 360 aatcactttg ctttagcttt tttgtgcaga gaagggaagg acttatccct gtcacaccaa 420 aatccataca tgtaagaggc aggctttccc gttccacctc tgggtgctcc ttttcccact 480 cacgccttac aaacaagagg gagtctgaca gcctttctct tctctcagtg ctaacaactt 540 tgcaatgaaa ggaaagcgga agacgctgaa tgccagtgat gtgctctcag ccatggaaga 600 gatggagttc cagcggttcg ttaccccatt gaaagaagct ctggaagcat ataggcggga 660 gcagaaaggc aagaaggagg cctcagagca aaagaagaag gacaaagaca aaaaaacaga 720 ctcggaagag caagacaaga gcagggatga ggacaatgat gaagacgaag aaaggctgga 780 agaagaagaa cagaatgaag aggaagaagt agacaactga aaagggcggg agactgtggc 840 accttggaag gtaccacttg aaatgagacg tgctacgtgt ttctgtgaag cttttccatg 900 ctgggcagag tagtctcagg caaaagtgcc tgaaaagatc agaataaaaa ctgactagaa 960 ataccgtcaa aaccagcact taccaaactc agagcatctg agtagcagaa tcctgttttg 1020 cttcatcaat ctgaaggtta tggccttttg acaagaggga ttctgaacga ctaaattagt 1080 cagtttgctc gcttttgttt acttaaatgt atggttagat ggtttttgat ctgcagtctt 1140 ccctagtccc ccaaataagt aataataact tccatgctgc ctgctgtgtt ccagatcaca 1200 gaggcagcca aggctcagga aaaactgggg ctttgcttat ggtcagccta tgtttgattg 1260 cacagtcttt gacaatagta gcttactaag actgctcaga atgagtaagc tttaggaaac 1320 tactaaaatg ctgtgggaga ataacaaaat ccgttctctc tcttcacttg acagaagcat 1380 taactgaatt ttgtttttca tagacccact tggcccaaaa cctttctata ttgcctgtag 1440 atgatcggcc tgctggtgtg gtagtaatct gatcacagat attcttaaat cagcagtgtg 1500 gaatggtatt agtcaaacat ggtgccagtg tcttttacaa aaacagatgg catagtgtca 1560 gatgtacctt actctctgct actgtacagc tttaggattt gtcatcacct cccggaaggt 1620 gtaaaacccc aggcttcctc ttcttgtagt ccatctccca gacttgtgac tatggctttt 1680 cattcttcaa ttcatgacga gtgccaaact tgattttctc taggcacagc tttctccctc 1740 tgtgcctcct gcttcctttc tctctcctgc ctctcctctg ctccccatcc cactttctca 1800 tctgcctcct tttctcactt ctgtcagtct gtaagctttg ataacctgct taatactcca 1860 aagtgtgagt tcctctgata tcttgattcc ttagttctaa tctcacgttt tgtttttaag 1920 agatggagtc tctcactctg tggcccaggc tggagtgcag tggcatgatc atagctcatt 1980 gcatccttga aatcctgggc tcaggtgatc ctcccgcctg agcctcctga gtatctggga 2040 ctacagatgc gtgccaccaa gcctggctaa ttttgtctca tgtcttctaa aaattatttt 2100 gtgaagcccc ttcacaaaaa accttaaggg aaatctgatg gtgctcagga atctaactct 2160 ccctaaacca tcctctttaa ctgcttctaa aatatctctg ttggcctttc ttagcctttt 2220 tctgtttcca ttcagtgctc caagcgcttt ttgtttctaa gttgagtgct tggggtttga 2280 caggtagtga cgtgtagttt gacactgtta acttgttaaa tacagtgaaa agtttgtgag 2340 tgaagaatgc tgagaagatt gtaatgcttt gtacaaataa aagtcttgtt 2390 <210> 197 <211> 794 <212> DNA <213> Homo sapiens <400> 197 tagcggcagc ggctccggca gggtctgcgc gacggatgga agcggatagt gtctccgact 60 ctctcagcct ctcgctccgc gtccgggcag cacgctcaag gccgggatgg cggcggcggc 120 ggcggcagga agcgggacgc cccgagagga ggaggtacct gctggggagg cagcggcctc 180 gcagccccag gccccaacga gtgtgcctgg ggctcgtctc tcgaggttgc ctctggcgcg 240 agtgaaggcc ttggtgaagg cagatcccga cgtgacgcta gcgggacagg aagccatctt 300 cattctggca cgagccgcgg aactgtttgt ggagaccatt gcaaaagatg cctactgttg 360 cgctcagcag ggaaaaagga aaacccttca gaggagagac ttggataatg caatagaagc 420 tgtggatgaa tttgcttttc tggaaggtac tttagattga ttgccgagcg gggcagtttt 480 gtgagccttc atctgaagcc ttcagttcac ccctctgcac aggcctcagc tttgaagaac 540 ggagtctttg cacttacaca cactcttcct gttctgcctt cacctatgcc gggataagca 600 gagatctcat caattagctc ttctctgcaa ggtcttccac tatttctgtc tgtcttccat 660 atcaagcctg gatgcagctg ctgctgctta gagcagagat gaagaaagtg ttctgcataa 720 gtggcttcct gaatgatgag gaccagaata aaggtttttg atcaacctca aaaaaaaaaa 780 aaaaaaaaaa aaaa 794 <210> 198 <211> 708 <212> DNA <213> Homo sapiens <400> 198 gccgcgcgca gcacgctcaa ggccgggatg gcggcggcgg cggcggcagg aagcgggacg 60 ccccgagagg aggaggtacc tgctggggag gcagcggcct cgcagcccca ggccccaacg 120 agtgtgcctg gggctcgtct ctcgaggttg cctctggcgc gagtgaaggc cttggtgaag 180 gcagatcccg acgtgacgct agcgggacag gaagccatct tcattctggc acgagccgcg 240 gaactgtttg tggagaccat tgcaaaagat gcctactgtt gcgctcagca gggaaaaagg 300 aaaacccttc agaggagaga cttggataat gcaatagaag ctgtggatga atttgctttt 360 ctggaaggta ctttagattg attgccgagc ggggcagttt tgtgagcctt catctgaagc 420 cttcagttca cccctctgca caggcctcag ctttgaagaa cggagtcttt gcacttacac 480 acactcttcc tgttctgcct tcacctatgc cgggataagc agagatctca tcaattagct 540 cttctctgca aggtcttcca ctatttctgt ctgtcttcca tatcaagcct ggatgcagct 600 gctgctgctt agagcagaga tgaagaaagt gttctgcata agtggcttcc tgaatgatga 660 ggaccagaat aaaggttttt gatcaacctc aaaaaaaaaa aaaaaaaa 708 <210> 199 <211> 710 <212> DNA <213> Homo sapiens <400> 199 cggcggccgc gcgcagcacg ctcaaggccg ggatggcggc ggcggcggcg gcaggaagcg 60 ggacgccccg agaggaggag ggacctgctg gggaggcagc ggcctcgcag ccccaggccc 120 caacgagtgt gcctggggct cgtctctcga ggttgcctct ggcgcgagtg aaggccttgg 180 tgaaggcaga tcccgacgtg acgctagcgg gacaggaagc catcttcatt ctggcacgag 240 ccgcggaact gtttgtggag accattgcaa aagatgccta ctgttgcgct cagcagggaa 300 aaaggaaaac ccttcagagg agagacttgg ataatgcaat agaagctgtg gatgaatttg 360 cttttctgga aggtacttta gattgattgc cgagcggggc agttttgtga gccttcatct 420 gaagccttca gttcacccct ctgcacaggc ctcagctttg aagaacggag tctttgcact 480 tacacacact cttcctgttc tgccttcacc tatgccggga taagcagaga tctcatcaat 540 tagctcttct ctgcaaggtc ttccactatt tctgtctgtc ttccatatca agcctggatg 600 cagctgctgc tgcttagagc agagatgaag aaagtgttct gcataagtgg cttcctgaat 660 gatgaggacc agaataaagg tttttgatca acctcaaaaa agaaaaaaaa 710 <210> 200 <211> 306 <212> DNA <213> Homo sapiens <400> 200 gaccattgca aaagatgcct actgttgcgc tcagcaggga aaaaggaaaa cccttcagag 60 gagagacttg gataatgcaa tagaagctgt ggatgaatct gcttttctgg aaggaaataa 120 ccaggaatgc aaagagctta tcacctcatt atttacaaca gtgaaaatgg aaaaagtaag 180 cctaaatcgg gtgatagtta atcaaattat agtagacacc tctagacata ttttgaaaat 240 ataaaaatta ttatacagaa tttttaatga caacagaaaa atgttaattt taacgaaaaa 300 aaaaaa 306 <210> 201 <211> 3734 <212> DNA <213> Homo sapiens <400> 201 caaatgcgaa cttaggctgt tacacaactg ctggggtctg ttctcgccgc ccgcccggca 60 gtcaggcagc gtcgccgccg tggtagcagc ctcagccgtt tctggagtct cgggcccaca 120 gtcaccgccg cttacctgcg cctcctcgag cctccggagt ccccgtccgc ccgcacaggc 180 cggttcgccg tctgcgtctc ccccacgccg cctcgcctgc cgccgcgctc gtccctccgg 240 gccgacatga gtggggacca cctccacaac gattcccaga tcgaagcgga tttccgattg 300 aatgattctc ataaacacaa agataaacac aaagatcgag aacaccggca caaagaacac 360 aagaaggaga aggaccggga aaagtccaag catagcaaca gtgaacataa agattctgaa 420 aagaaacaca aagagaagga gaagaccaaa cacaaagatg gaagctcaga aaagcataaa 480 gacaaacata aagacagaga caaggaaaaa cgaaaagagg aaaaggttcg agcctctggg 540 gatgcaaaaa taaagaagga gaaggaaaat ggcttctcta gtccaccaca aattaaagat 600 gaacctgaag atgatggcta ttttgttcct cctaaagagg atataaagcc attaaagaga 660 cctcgagatg aggatgatgc tgattataaa cctaagaaaa ttaaaacaga agataccaag 720 aaggagaaga aaagaaaact agaagaagaa gaggatggta aattgaaaaa acccaagaat 780 aaagataaag ataaaaaagt tcctgagcca gataacaaga aaaagaagcc gaagaaagaa 840 gaggaacaga agtggaaatg gtgggaagaa gagcgctatc ctgaaggcat caagtggaaa 900 ttcctagaac ataaaggtcc agtatttgcc ccaccatatg agcctcttcc agagaatgtc 960 aagttttatt atgatggtaa agtcatgaag ctgagcccca aagcagagga agtagctacg 1020 ttctttgcaa aaatgctcga ccatgaatat actaccaagg aaatatttag gaaaaatttc 1080 tttaaagact ggagaaagga aatgactaat gaagagaaga atattatcac caacctaagc 1140 aaatgtgatt ttacccagat gagccagtat ttcaaagccc agacggaagc tcggaaacag 1200 atgagcaagg aagagaaact gaaaatcaaa gaggagaatg aaaaattact gaaagaatat 1260 ggattctgta ttatggataa ccacaaagag aggattgcta acttcaagat agagcctcct 1320 ggacttttcc gtggccgcgg caaccacccc aagatgggca tgctgaagag acgaatcatg 1380 cccgaggata taatcatcaa ctgtagcaaa gatgccaagg ttccttctcc tcctccagga 1440 cataagtgga aagaagtccg gcatgataac aaggttactt ggctggtttc ctggacagag 1500 aacatccaag gttccattaa atacatcatg cttaacccta gttcacgaat caagggtgag 1560 aaggactggc agaaatacga gactgctcgg cggctgaaaa aatgtgtgga caagatccgg 1620 aaccagtatc gagaagactg gaagtccaaa gagatgaaag tccggcagag agctgtagcc 1680 ctgtacttca tcgacaagct tgctctgaga gcaggcaatg aaaaggagga aggagaaaca 1740 gcggacactg tgggctgctg ctcacttcgt gtggagcaca tcaatctaca cccagagttg 1800 gatggtcagg aatatgtggt agagtttgac ttcctcggga aggactccat cagatactat 1860 aacaaggtcc ctgttgagaa acgagttttt aagaacctac aactatttat ggagaacaag 1920 cagcccgagg atgatctttt tgatagactc aatactggta ttctgaataa gcatcttcag 1980 gatctcatgg agggcttgac agccaaggta ttccgtacat acaatgcctc catcacgcta 2040 cagcagcagc taaaagaact gacagccccg gatgagaaca tcccagcgaa gatcctttct 2100 tataaccgtg ccaatcgagc tgttgcaatt ctttgtaacc atcagagggc accaccaaaa 2160 acttttgaga agtctatgat gaacttgcaa actaagattg atgccaagaa ggaacagcta 2220 gcagatgccc ggagagacct gaaaagtgct aaggctgatg ccaaggtcat gaaggatgca 2280 aagacgaaga aggtagtaga gtcaaagaag aaggctgttc agagactgga ggaacagttg 2340 atgaagctgg aagttcaagc cacagaccga gaggaaaata aacagattgc cctgggaacc 2400 tccaaactca attatctgga ccctaggatc acagtggctt ggtgcaagaa gtggggtgtc 2460 ccaattgaga agatttacaa caaaacccag cgggagaagt ttgcctgggc cattgacatg 2520 gctgatgaag actatgagtt ttagccagtc tcaagaggca gagttctgtg aagaggaaca 2580 gtgtggtttg ggaaagatgg ataaactgag cctcacttgc cctcgtgcct gggggagaga 2640 ggcagcaagt cttaacaaac caacatcttt gcgaaaagat aaacctggag atattataag 2700 ggagagctga gccagttgtc ctatggacaa cttatttaaa aatatttcag atatcaaaat 2760 tctagctgta tgatttgttt tgaattttgt ttttattttc aagagggcaa gtggatggga 2820 atttgtcagc gttctaccag gcaaattcac tgtttcactg aaatgtttgg attctcttag 2880 ctactgtatg caaagtccga ttatattggt gcgtttttac agttagggtt ttgcaataac 2940 ttctatattt taatagaaat aaattcctaa actcccttcc ctctctccca tttcaggaat 3000 ttaaaattaa gtagaacaaa aaacccagcg cacctgttag agtcgtcact ctctattgtc 3060 atggggatca attttcatta aacttgaagc agtcgtggct ttggcagtgt tttggttcag 3120 acacctgttc acagaaaaag catgatggga aaatatttcc tgacttgagt gttccttttt 3180 aaatgtgaat ttttatttct ttttaattat tttaaaatat ttaaaccttt ttcttgatct 3240 taaagatcgt gtagattggg gttggggagg gatgaagggc gagtgaatct aaggataatg 3300 aaataatcag tgactgaaac cattttccca tcatcctttg ttctgagcat tcgctgtacc 3360 ctttaagata tccatctttt tctttttaac cctaatcttt cacttgaaag attttattgt 3420 ataaaaagtt tcacaggtca ataaacttag aggaaaatga gtatttggtc caaaaaaagg 3480 aaaaataatc aagattttag ggcttttatt ttttcttttg taattgtgta aaaaatggaa 3540 aaaaacataa aaagcagaat tttaatgtga agacattttt tgctataatc attagtttta 3600 gaggcattgt tagtttagtg tgtgtgcaga gtccatttcc cacatctttc ctcaagtatc 3660 ttctattttt atcatgaatt cccttttaat caactgtagg ttatttaaaa taaattccta 3720 caacttaatg gaaa 3734 <210> 202 <211> 3645 <212> DNA <213> Homo sapiens <400> 202 gaattcgggc gccgcccgcc cggcagtcag gcagcgtcgc cgccgtggta gcagcctcag 60 ccgtttctgg agtctcgggc ccacagtcac cgccgcttac ctgcgcctcc tcgagcctcc 120 ggagtccccg tccgcccgca caggccggtt cgccgtctgc gtctccccca cgccgcctcg 180 cctgccgccg cgctcgtccc tccgggccga catgagtggg gaccacctcc acaacgattc 240 ccagatcgaa gcggatttcc gattgaatga ttctcataaa cacaaagata aacacaaaga 300 tcgagaacac cggcacaaag aacacaagaa ggagaaggac cgggaaaagt ccaagcatag 360 caacagtgaa cataaagatt ctgaaaagaa acacaaagag aaggagaaga ccaaacacaa 420 agatggaagc tcagaaaagc ataaagacaa acataaagac agagacaagg aaaaacgaaa 480 agaggaaaag gttcgagcct ctggggatgc aaaaataaag aaggagaagg aaaatggctt 540 ctctagtcca ccacaaatta aagatgaacc tgaagatgat ggctattttg ttcctcctaa 600 agaggatata aagccattaa agagacctcg agatgaggat gatgttgatt ataaacctaa 660 gaaaattaaa acagaagata ccaagaagga gaagaaaaga aaactagaag aagaagagga 720 tggtaaattg aaaaaaccca agaataaaga taaagataaa aaagttcctg agccagataa 780 caagaaaaag aagccgaaga aagaagagga acagaagtgg aaatggtggg aagaagagcg 840 ctatcctgaa ggcatcaagt ggaaattcct agaacataaa ggtccagtat ttgccccacc 900 atatgagcct cttccagaga atgtcaagtt ttattatgat ggtaaagtca tgaagctgag 960 ccccaaagca gaggaagtag ctacgttctt tgcaaaaatg ctcgaccatg aatatactac 1020 caaggaaata tttaggaaaa atttctttaa agactggaga aaggaaatga ctaatgaaga 1080 gaagaatatt atcaccaacc taagcaaatg tgattttacc cagatgagcc agtatttcaa 1140 agcccagacg gaagctcgga aacagatgag caaggaagag aaactgaaaa tcaaagagga 1200 gaatgaaaaa ttactgaaag aatatggatt ctgtattatg gataaccaca aagagaggat 1260 tgctaacttc aagatagagc ctcctggact tttccgtggc cgcggcaacc accccaagat 1320 gggcatgctg aagagacgaa tcatgcccga ggatataatc atcaactgta gcaaagatgc 1380 caaggttcct tctcctcctc caggacataa gtggaaagaa gtccggcatg ataacaaggt 1440 tacttggctg gtttcctgga cagagaacat ccaaggttcc attaaataca tcatgcttaa 1500 ccctagttca cgaatcaagg gtgagaagga ctggcagaaa tacgagactg ctcggcggct 1560 gaaaaaatgt gtggacaaga tccggaacca gtatcgagaa gactggaagt ccaaagagat 1620 gaaagtccgg cagagagctg tagccctgta cttcatcgac aagcttgctc tgagagcagg 1680 caatgaaaag gaggaaggag aaacagcgga cactgtgggc tgctgctcac ttcgtgtgga 1740 gcacatcaat ctacacccag agttggatgg tcaggaatat gtggtagagt ttgacttcct 1800 cgggaaggac tccatcagat actataacaa ggtccctgtt gagaaacgag tttttaagaa 1860 cctacaacta tttatggaga acaagcagcc cgaggatgat ctttttgata gactcaatac 1920 tggtattctg aataagcatc ttcaggatct catggagggc ttgacagcca aggtattccg 1980 tacgtacaat gcctccatca cgctacagca gcagctaaaa gaactgacag ccccggatga 2040 gaacatccca gcgaagatcc tttcttataa ccgtgccaat cgagctgttg caattctttg 2100 taaccatcag agggcaccac caaaaacttt tgagaagtct atgatgaact tgcaaactaa 2160 gattgatgcc aagaaggaac agctagcaga tgcccggaga gacctgaaaa gtgctaaggc 2220 tgatgccaag gtcatgaagg atgcaaagac gaagaaggta gtagagtcaa agaagaaggc 2280 tgttcagaga ctggaggaac agttgatgaa gctggaagtt caagccacag accgagagga 2340 aaataaacag attgccctgg gaacctccaa actcaattat ctggacccta ggatcacagt 2400 ggcttggtgc aagaagtggg gtgtcccaat tgagaagatt tacaacaaaa cccagcggga 2460 gaagtttgcc tgggccattg acatggctga tgaagactat gagttttagc cagtctcaag 2520 aggcagagtt ctgtgaagag gaacagtgtg gtttgggaaa gatggataaa ctgagcctca 2580 cttgccctcg tgcctggggg agagaggcag caagtcttaa caaaccaaca tctttgcgaa 2640 aagataaacc tggagatatt ataagggaga gctgagccag ttgtcctatg gacaacttat 2700 ttaaaaatat ttcagatatc aaaattctag ctgtatgatt tgttttgaat tttgttttta 2760 ttttcaagag ggcaagtgga tgggaatttg tcagcgttct accaggcaaa ttcactgttt 2820 cactgaaatg tttggattct cttagctact gtatgcaaag tccgattata ttggtgcgtt 2880 tttacagtta gggttttgca ataacttcta tattttaata gaaataaatt cctaaactcc 2940 cttccctctc tcccatttca ggaatttaaa attaagtaga acaaaaaacc cagcgcacct 3000 gttagagtcg tcactctcta ttgtcatggg gatcaatttt cattaaactt gaagcagtcg 3060 tggctttggc agtgttttgg ttcagacacc tgttcacaga aaaagcatga tgggaaaata 3120 tttcctgact tgagtgttcc tttttaaatg tgaatttttt ttttttttaa ttattttaaa 3180 atatttaaac ctttttcttg atcttaaaga tcgtgtagat tggggttggg gagggatgaa 3240 gggcgagtga atctaaggat aatgaaataa tcagtgactg aaaccatttt cccatcatcc 3300 tttgttctga gcattcgctg taccctttaa gatatccatc tttttctttt taaccctaat 3360 ctttcacttg aaagatttta ttgtataaaa agtttcacag gtcaataaac ttagaggaaa 3420 atgagtattt ggtccaaaaa aaggaaaaat aatcaagatt ttagggcttt tattttttct 3480 tttgtaattg tgtaaaaaat ggaaaaaaac ataaaaagca gaattttaat gtgaagacat 3540 tttttgctat aatcattagt tttagaggca ttgttagttt agtgtgtgtg cagagtccat 3600 ttcccacatc tttcctcaag tatcttctat ttttatcatg aattc 3645 <210> 203 <211> 3477 <212> DNA <213> Homo sapiens <400> 203 accacctcca caacgattcc cagatcgaag cggatttccg attgaatgat tctcataaac 60 acaaagataa acacaaagat cgagaacacc ggcacaaaga acacaagaag gagaaggacc 120 gggaaaagtc caagcatagc aacagtgaac ataaagattc tgaaaagaaa cacaaagaga 180 aggagaagac caaacacaaa gatggaagct cagaaaagca taaagacaaa cataaagaca 240 gagacaagga aaaacgaaaa gaggaaaagg ttcgagcctc tggggatgca aaaataaaga 300 aggagaagga aaatggcttc tctagtccac cacaaattaa agatgaacct gaagatgatg 360 gctattttgt tcctcctaaa gaggatataa agccattaaa gagacctcga gatgaggatg 420 atgctgatta taaacctaag aaaattaaaa cagaagatac caagaaggag aagaaaagaa 480 aactagaaga agaagaggat ggtaaattga aaaaacccaa gaataaagat aaagataaaa 540 aagttcctga gccagataac aagaaaaaga agccgaagaa agaagaggaa cagaagtgga 600 aatggtggga agaagagcgc tatcctgaag gcatcaagtg gaaattccta gaacataaag 660 gtccagtatt tgccccacca tatgagcctc ttccagagaa tgtcaagttt tattatgatg 720 gtaaagtcat gaagctgagc cccaaagcag aggaagtagc tacgttcttt gcaaaaatgc 780 tcgaccatga atatactacc aaggaaatat ttaggaaaaa tttctttaaa gactggagaa 840 aggaaatgac taatgaagag aagaatatta tcaccaacct aagcaaatgt gattttaccc 900 agatgagcca gtatttcaaa gcccagacgg aagctcggaa acagatgagc aaggaagaga 960 aactgaaaat caaagaggag aatgaaaaat tactgaaaga atatggattc tgtattatgg 1020 ataaccacaa agagaggatt gctaacttca agatagagcc tcctggactt ttccgtggcc 1080 gcggcaacca ccccaagacg ggcatgctga agagacgaat catgcccgag gatataatca 1140 tcaactgtag caaagatgcc aaggttcctt ctcctcctcc aggacataag tggaaagaag 1200 tccggcatga taacaaggtt acttggctgg tttcctggac agagaacatc caaggttcca 1260 ttaaatacat catgcttaac cctagttcac gaatcaaggg tgagaaggac tggcagaaat 1320 acgagactgc tcggcggctg aaaaaatgtg tggacaagat ccggaaccag tatcgagaag 1380 actggaagtc caaagagatg aaagtccggc agagagctgt agccctgtac ttcatcgaca 1440 agcttgctct gagagcaggc aatgaaaagg aggaaggaga aacagcggac actgtgggct 1500 gctgctcact tcgtgtggag cacatcaatc tacacccaga gttggatggt caggaatatg 1560 tggtagagtt tgacttcctc gggaaggact ccatcagata ctataacaag gtccctgttg 1620 agaaacgagt ttttaagaac ctacaactat ttatggagaa caagcagccc gaggatgatc 1680 tttttgatag actcaatact ggtattctga ataagcatct tcaggatctc atggagggct 1740 tgacagccaa ggtattccgt acatacaatg cctccatcac gctacagcag cagctaaaag 1800 aactgacagc cccggatgag aacatcccag cgaagatcct ttcttataac cgtgccaatc 1860 gagctgttgc aattctttgt aaccatcaga gggcaccacc aaaaaccttt gagaagtcta 1920 tgatgaactt gcaaactaag attgatgcca agaaggaaca gctagcagat gcccggagag 1980 acctgaaaag tgctaaggct gatgccaagg tcatgaagga tgcaaagacg aagaaggtag 2040 tagagtcaaa gaagaaggct gttcagagac tggaggaaca gttgatgaag ctggaagttc 2100 aagccacaga ccgagaggaa aataaacaga ttgccctggg aacctccaaa ctcagttatc 2160 tggaccctag gatcacagtg gcttggtgca agaagtgggg tgtcccaatt gagaagattt 2220 acaacaaaac ccagcgggag aagtttgcct gggccattga catggctgat gaagactatg 2280 agttttagcc agtctcaaga ggcagagttc tgtgaagagg aacagtgtgg tttgggaaag 2340 atggataaac tgagcctcac ttgccctcgt gcctggggga gagaggcagc aagtcttaac 2400 aaaccaacat ctttgcgaaa agataaacct ggagatatta taagggagag ctgagccagt 2460 tgtcctatgg acaacttatt taaaaatatt tcagatatca aaattctagc tgtatgattt 2520 gttttgaatt ttgtttttat tttcaagagg gcaagtggat gggaatttgt cagcgttcta 2580 ccaggcaaat tcactgtttc actgaaatgt ttggattctc ttagctactg tatgcaaagt 2640 ccgattatat tggtgcgttt ttacagttag ggttttgcaa taacttctat attttaatag 2700 aaataaattc ctaaactccc ttccctctct cccatttcag gaatttaaaa ttaagtagaa 2760 caaaaaaccc agcgcacctg ttagagtcgt cactctctat tgtcatgggg atcaattttc 2820 attaaacttg aagcagtcgt ggctttggca gtgttttggt tcagacacct gttcacagaa 2880 aaagcatgat gggaaaatat ttcctgactt gagtgttcct ttttaaatgt gaattttttt 2940 tttttttaat tattttaaaa tatttaaacc tttttcttga tcttaaagat cgtgtagatt 3000 ggggttgggg agggatgaag ggcgagtgaa tctaaggata atgaaataat cagtgactga 3060 aaccattttc ccatcatcct ttgttctgag cattcgctgt accctttaag atatccatct 3120 ttttcttttt aaccctaatc tttcacttga aagattttat tgtataaaaa gtttcacagg 3180 tcaataaact tagaggaaaa tgagtatttg gtccaaaaaa aggaaaaata atcaagattt 3240 tagggctttt attttttctt ttgtaattgt gtaaaaaatg gaaaaaaaca taaaaagcag 3300 aattttaatg tgaagacatt ttttgctata atcattagtt ttagaggcat tgttagttta 3360 gtgtgtgtgc agagtccatt tcccacatct ttcctcaagt atcttctatt tttatcatga 3420 attccctttt aatcaactgt aggttattta aaataaattc ctacaactta atggaaa 3477 <210> 204 <211> 2469 <212> DNA <213> Homo sapiens <400> 204 accacctcca caacgattcc cagatcgaag cggatttccg attgaatgat tctcataaac 60 acaaagataa acacaaagat cgagaacacc ggcacaaaga acacaagaag gagaaggacc 120 gggaaaagtc caagcatagc aacagtgaac ataaagattc tgaaaagaaa cacaaagaga 180 aggagaagac caaacacaaa gatggaagct cagaaaagca taaagacaaa cataaagaca 240 gagacaagga aaaacgaaaa gaggaaaagg ttcgagcctc tggggatgca aaaataaaga 300 aggagaagga aaatggcttc tctagtccac cacaaattaa agatgaacct gaagatgatg 360 gctattttgt tcctcctaaa gaggatataa agccattaaa gagacctcga gatgaggatg 420 atgctgatta taaacctaag aaaattaaaa cagaagatac caagaaggag aagaaaagaa 480 aactagaaga agaagaggat ggtaaattga aaaaacccaa gaataaagat aaagataaaa 540 aagttcctga gccagataac aagaaaaaga agccgaagaa agaagaggaa cagaagtgga 600 aatggtggga agaagagcgc tatcctgaag gcatcaagtg gaaattccta gaacataaag 660 gtccagtatt tgccccacca tatgagcctc ttccagagaa tgtcaagttt tattatgatg 720 gtaaagtcat gaagctgagc cccaaagcag aggaagtagc tacgttcttt gcaaaaatgc 780 tcgaccatga atatactacc aaggaaatat ttaggaaaaa tttctttaaa gactggagaa 840 aggaaatgac taatgaagag aagaatatta tcaccaacct aagcaaatgt gattttaccc 900 agatgagcca gtatttcaaa gcccagacgg aagctcggaa acagatgagc aaggaagaga 960 aactgaaaat caaagaggag aatgaaaaat tactgaaaga atatggattc tgtattatgg 1020 ataaccacaa agagaggatt gctaacttca agatagagcc tcctggactt ttccgtggcc 1080 gcggcaacca ccccaagatg ggcatgctga agagacgaat catgcccgag gatataatca 1140 tcaactgtag caaagatgcc aaggttcctt ctcctcctcc aggacataag tggaaagaag 1200 tccggcatga taacaaggtt acttggctgg tttcctggac agagaacatc caaggttcca 1260 ttaaatacat catgcttaac cctagttcac gaatcaaggg tgagaaggac tggcagaaat 1320 acgagactgc tcggcggctg aaaaaatgtg tggacaagat ccggaaccag tatcgagaag 1380 actggaagtc caaagagatg aaagtccggc agagagctgt agccctgtac ttcatcgaca 1440 agcttgctct gagagcaggc aatgaaaagg aggaaggaga aacagcggac actgtgggct 1500 gctgctcact tcgtgtggag cacatcaatc tacacccaga gttggatggt caggaatatg 1560 tggtagagtt tgacttcctc gggaaggact ccatcagata ctataacaag gtccctgttg 1620 agaaacgagt ttttaagaac ctacaactat ttatggagaa caagcagccc gaggatgatc 1680 tttttgatag actcaatact ggtattctga ataagcatct tcaggatctc atggagggct 1740 tgacagccaa ggtattccgt acgtacaatg cctccatcac gctacagcag cagctaaaag 1800 aactgacagc cccggatgag aacatcccag cgaagatcct ttcttataac cgtgccaatc 1860 gagctgttgc aattctttgt aaccatcaga gggcaccacc aaaaactttt gagaagtcta 1920 tgatgaactt gcaaactaag attgatgcca agaaggaaca gctagcagat gcccggagag 1980 acctgaaaag tgctaaggct gatgccaagg tcatgaagga tgcaaagacg aagaaggtag 2040 tagagtcaaa gaagaaggct gttcagagac tggaggaaca gttgatgaag ctggaagttc 2100 aagccacaga ccgagaggaa aataaacaga ttgccctggg aacctccaaa ctcaattatc 2160 tggaccctag gatcacagtg gcttggtgca agaagtgggg tgtcccaatt gagaagattt 2220 acaacaaaac ccagcgggag aagtttgcct gggccattga catggctgat gaagactatg 2280 agttttagcc agtctcaaga ggcagagttc tgtgaagagg aacagtgtgg tttgggaaag 2340 atggataaac tgagcctcac ttgccctcgt gcctggggga gagaggcagc aagtcttaac 2400 aaaccaacat ctttgcgaaa agataaacct ggagatatta taagggagag ctgagccagt 2460 tgtcctatg 2469 <210> 205 <211> 1817 <212> DNA <213> Homo sapiens <400> 205 gaattccggt ccctgttgag aaacgagttt ttaagaacct acaactattt atggagaaca 60 agcagcccga ggatgatctt tttgatagac tcaatactgg tattctgaat aagcatcttc 120 aggatctcat ggagggcttg acagccaagg tattccgtac gtacaatgcc tccatcacgc 180 tacagcagca gctaaaagaa ctgacagccc cggatgagaa catcccagcg aagatccttt 240 cttataaccg tgccaatcga gctgttgcaa ttctttgtaa ccatcagagg gcaccaccaa 300 aaacttttga gaagtctatg atgaacttgc aaactaagat tgatgccaag aaggaacagc 360 tagcagatgc ccggagagac ctgaaaagtg ctaaggctga tgccaaggtc atgaaggatg 420 caaagacgaa gaaggtagta gagtcaaaga agaaggctgt tcagagactg gaggaacagt 480 tgatgaagct ggaagttcaa gccacagacc gagaggaaaa taaacagatt gccctgggaa 540 cctccaaact caattatctg gaccctagga tcacagtggc ttggtgcaag aagtggggtg 600 tcccaattga gaagatttac aacaaaaccc agcgggagaa gtttgcctgg gccattgaca 660 tggctgatga agactatgag ttttagccag tctcaagagg cagagttctg tgaagaggaa 720 cagtgtggtt tgggaaagat ggataaactg agcctcactt gccctcgtgc ctgggggaga 780 gaggcagcaa gtcttaacaa accaacatct ttgcgaaaag ataaacctgg agatattata 840 agggagagct gagccagttg tcctatggac aacttattta aaaatatttc agatatcaaa 900 attctagctg tatgatttgt tttgaatttt gtttttattt tcaagagggc aagtggatgg 960 gaatttgtca gcgttctacc aggcaaattc actgtttcac tgaaatgttt ggattctctt 1020 agctactgta tgcaaagtcc gattatattg gtgcgttttt acagttaggg ttttgcaata 1080 acttctatat tttaatagaa ataaattcct aaactccctt ccctctctcc catttcagga 1140 atttaaaatt aagtagaaca aaaaacccag cgcacctgtt agagtcgtca ctctctattg 1200 tcatggggat caattttcat taaacttgaa gcagtcgtgg ctttggcagt gttttggttc 1260 agacacctgt tcacagaaaa agcatgatgg gaaaatattt cctgacttga gtgttccttt 1320 ttaaatgtga atttttattt ctttttaatt attttaaaat atttaaacct ttttcttgat 1380 cttaaagatc gtgtagattg gggttgggga gggatgaagg gcgagtgaat ctaaggataa 1440 tgaaataatc agtgactgaa accattttcc catcatcctt tgttctgagc attcgctgta 1500 ccctttaaga tatccatctt tttcttttta accctaatct ttcacttgaa agattttatt 1560 gtataaaaag tttcacaggt caataaactt agaggaaaat gagtatttgg tccaaaaaaa 1620 ggaaaaataa tcaagatttt agggctttta ttttttcttt tgtaattgtg taaaaaatgg 1680 aaaaaaacat aaaaagcaga attttaatgt gaagacattt tttgctataa tcattagttt 1740 tagaggcatt gttagtttag tgtgtgtgca gagtccattt cccacatctt tcctcaagta 1800 tcttctattt ttatcat 1817 <210> 206 <211> 2344 <212> DNA <213> Homo sapiens <400> 206 gttggttctg tgcgcctcag agttggagca cacagctgta ttaaaaaggc aaatcgaagg 60 ccgggcgcgg tgactcacgc ctgtcatcct agcactttgg gaggccgagg cggctgaatc 120 acttgaggtt aggagtttga gatcagcccg ggcaacatgg tgaaaccccg tctctacaaa 180 aatagaaaaa ttagccgagc gtgatggtgg atgcctgtaa tcctagctcc tcgggaggct 240 aaggagtata atgtctcagg aaggcgatta tgggaggtgg accatatcta gtagtgatga 300 aagtgaggaa gaaaagccaa aaccagacaa gccatctacc tcttctcttc tctgtgccag 360 gcaaggagca gcaaatgagc ccaggtacac ctgttccgag gcccagaaag ctgcacacaa 420 gaggaaaata tcacctgtga aattcagcaa tacagattca gttttacctc ccaaaaggca 480 gaaaagcggt tcccaggagg acctcggctg gtgtctgtcc agcagtgatg atgagctgca 540 accagaaatg ccgcagaagc aggctgagaa agtggtgatc aaaaaggaga aagacatctc 600 tgctcccaat gacggcactg cccaaagaac tgaaaatcat ggcgctcccg cctgccacag 660 gctcaaagag gaggaagacg agtatgagac atcaggggag ggccaggaca tttgggacat 720 gctggataaa gggaacccct tccagtttta cctcactaga gtctctggag ttaagccaaa 780 gtataactct ggagccctcc acatcaagga tattttatct cctttatttg ggacgcttgt 840 ttcttcagct cagtttaact actgctttga cgtggactgg ctcgtaaaac agtatccacc 900 agagttcagg aagaagccaa tcctgcttgt gcatggtgat aagcgagagg ctaaggctca 960 cctccatgcc caggccaagc cttacgagaa catctctctc tgccaggcaa agttggatat 1020 tgcgtttgga acacaccaca cgaaaatgat gctgctgctc tatgaagaag gcctccgggt 1080 tgtcatacac acctccaacc tcatccatgc tgactggcac cagaaaactc aaggaatatg 1140 gttgagcccc ttatacccac gaattgctga tggaacccac aaatctggag agtcgccaac 1200 acattttaaa gctgatctca tcagttactt gatggcttat aatgcccctt ctctcaagga 1260 gtggatagat gtcattcaca agcacgatct ctctgaaaca aatgtttatc ttattggttc 1320 aaccccagga cgctttcaag gaagtcaaaa agataattgg ggacatttta gacttaagaa 1380 gcttctgaaa gaccatgcct catccatgcc taacgcagag tcctggcctg tcgtaggtca 1440 gttttcaagc gttggctcct tgggagccga tgaatcaaag tggttatgtt ctgagtttaa 1500 agagagcatg ctgacactgg ggaaggaaag caagactcca ggaaaaagct ctgttcctct 1560 ttacttgatc tatccttctg tggaaaatgt gcggaccagt ttagaaggat atcctgctgg 1620 gggctctctt ccctatagca tccagacagc tgaaaaacag aattggctgc attcctattt 1680 tcacaaatgg tcagctgaga cttctggccg cagcaatgcc atgccacata ttaagacata 1740 tatgaggcct tctccagact tcagtaaaat tgcttggttc cttgtcacaa gcgcaaatct 1800 gtccaaggct gcctggggag cattggagaa gaatggcacc cagctgatga tccgctccta 1860 cgagctcggg gtccttttcc tcccttcagc atttggtcta gacagtttca aagtgaaaca 1920 gaagttcttc gctggcagcc aggagccaat ggccaccttt cctgtgccat atgatttgcc 1980 tccagaactg tatggaagta aagatcggcc atggatatgg aacattcctt atgtcaaagc 2040 accggatacg catgggaaca tgtgggtgcc ctcctgagaa tcttgaggca ctgtgaaatt 2100 taagtgtaag acattgagcc acaaacatgg aatctcttct ttgtactgga tgtccacttc 2160 ccttaaagtc ttatttgcac ccttacaaaa tctttccaaa ggtcactctt atgaatggat 2220 gttggttata cttttaatgg acattaacat tcctaataaa gtattagttt cttaaaaaaa 2280 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2340 aaaa 2344 <210> 207 <211> 2344 <212> DNA <213> Homo sapiens <400> 207 gttggttctg tgcgcctcag agttggagca cacagctgta ttaaaaaggc aaatcgaagg 60 ccgggcgcgg tgactcacgc ctgtcatcct agcactttgg gaggccgagg cggctgaatc 120 acttgaggtt aggagtttga gatcagcccg ggcaacatgg tgaaaccccg tctctacaaa 180 aatagaaaaa ttagccgagc gtgatggtgg atgcctgtaa tcctagctcc tcgggaggct 240 aaggagtata atgtctcagg aaggcgatta tgggaggtgg accatatcta gtagtgatga 300 aagtgaggaa gaaaagccaa aaccagacaa gccatctacc tcttctcttc tctgtgccag 360 gcaaggagca gcaaatgagc ccaggtacac ctgttccgag gcccagaaag ctgcacacaa 420 gaggaaaata tcacctgtga aattcagcaa tacagattca gttttacctc ccaaaaggca 480 gaaaagcggt tcccaggagg acctcggctg gtgtctgtcc agcagtgatg atgagctgca 540 accagaaatg ccgcagaagc aggctgagaa agtggtgatc aaaaaggaga aagacatctc 600 tgctcccaat gacggcactg cccaaagaac tgaaaatcat ggcgctcccg cctgccacag 660 gctcaaagag gaggaagacg agtatgagac atcaggggag ggccaggaca tttgggacat 720 gctggataaa gggaacccct tccagtttta cctcactaga gtctctggag ttaagccaaa 780 gtataactct ggagccctcc acatcaagga tattttatct cctttatttg ggacgcttgt 840 ttcttcagct cagtttaact actgctttga cgtggactgg ctcgtaaaac agtatccacc 900 agagttcagg aagaagccaa tcctgcttgt gcatggtgat aagcgagagg ctaaggctca 960 cctccatgcc caggccaagc cttacgagaa catctctctc tgccaggcaa agttggatat 1020 tgcgtttgga acacaccaca cgaaaatgat gctgctgctc tatgaagaag gcctccgggt 1080 tgtcatacac acctccaacc tcatccatgc tgactggcac cagaaaactc aaggaatatg 1140 gttgagcccc ttatacccac gaattgctga tggaacccac aaatctggag agtcgccaac 1200 acattttaaa gctgatctca tcagttactt gatggcttat aatgcccctt ctctcaagga 1260 gtggatagat gtcattcaca agcacgatct ctctgaaaca aatgtttatc ttattggttc 1320 aaccccagga cgctttcaag gaagtcaaaa agataattgg ggacatttta gacttaagaa 1380 gcttctgaaa gaccatgcct catccatgcc taacgcagag tcctggcctg tcgtaggtca 1440 gttttcaagc gttggctcct tgggagccga tgaatcaaag tggttatgtt ctgagtttaa 1500 agagagcatg ctgacactgg ggaaggaaag caagactcca ggaaaaagct ctgttcctct 1560 ttacttgatc tatccttctg tggaaaatgt gcggaccagt ttagaaggat atcctgctgg 1620 gggctctctt ccctatagca tccagacagc tgaaaaacag aattggctgc attcctattt 1680 tcacaaatgg tcagctgaga cttctggccg cagcaatgcc atgccacata ttaagacata 1740 tatgaggcct tctccagact tcagtaaaat tgcttggttc cttgtcacaa gcgcaaatct 1800 gtccaaggct gcctggggag cattggagaa gaatggcacc cagctgatga tccgctccta 1860 cgagctcggg gtccttttcc tcccttcagc atttggtcta gacagtttca aagtgaaaca 1920 gaagttcttc gctggcagcc aggagccaat ggccaccttt cctgtgccat atgatttgcc 1980 tccagaactg tatggaagta aagatcggcc atggatatgg aacattcctt atgtcaaagc 2040 accggatacg catgggaaca tgtgggtgcc ctcctgagaa tcttgaggca ctgtgaaatt 2100 taagtgtaag acattgagcc acaaacatgg aatctcttct ttgtactgga tgtccacttc 2160 ccttaaagtc ttatttgcac ccttacaaaa tctttccaaa ggtcactctt atgaatggat 2220 gttggttata cttttaatgg acattaacat tcctaataaa gtattagttt cttaaaaaaa 2280 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2340 aaaa 2344 <210> 208 <211> 2068 <212> DNA <213> Homo sapiens <400> 208 atccgaggca ggcgttggtt ctgtgcgcct caggagtata atgtctcagg aaggcgatta 60 tgggaggtgg accatatcta gtagtgatga aagtgaggaa gaaaagccaa aaccagacaa 120 gccatctacc tcttctcttc tctgtgccag gcaaggagca gcaaatgagc ccaggtacac 180 ctgttccgag gcccagaaag ctgcacacaa gaggaaaata tcacctgtga aattcagcaa 240 tacagattca gttttacctc ccaaaaggca gaaaagcggt tcccaggagg acctcggctg 300 gtgtctgtcc agcagtgatg atgagctgca accagaaatg ccgcagaagc aggctgagaa 360 agtggtgatc aaaaaggaga aagacatctc tgctcccaat gacggcactg cccaaagaac 420 tgaaaatcat ggcgctcccg cctgccacag gctcaaagag gaggaagacg agtatgagac 480 atcaggggag ggccaggaca tttgggacat gctggataaa gggaacccct tccagtttta 540 cctcactaga gtctctggag ttaagccaaa gtataactct ggagccctcc acatcaagga 600 tattttatct cctttatttg ggacgcttgt ttcttcagct cagtttaact actgctttga 660 cgtggactgg ctcgtaaaac agtatccacc agagttcagg aagaagccaa tcctgcttgt 720 gcatggtgat aagcgagagg ctaaggctca cctccatgcc caggccaagc cttacgagaa 780 catctctctc tgccaggcaa agttggatat tgcgtttgga acacaccaca cgaaaatgat 840 gctgctgctc tatgaagaag gcctccgggt tgtcatacac acctccaacc tcatccatgc 900 tgactggcac cagaaaactc aaggaatatg gttgagcccc ttatacccac gaattgctga 960 tggaacccac aaatctggag agtcgccaac acattttaaa gctgatctca tcagttactt 1020 gatggcttat aatgcccctt ctctcaagga gtggatagat gtcattcaca agcacgatct 1080 ctctgaaaca aatgtttatc ttattggttc aaccccagga cgctttcaag gaagtcaaaa 1140 agataattgg ggacatttta gacttaagaa gcttctgaaa gaccatgcct catccatgcc 1200 taacccagag tcctggcctg tcgtaggtca gttttcaagc gttggctcct tgggagccga 1260 tgaatcaaag tggttatgtt ctgagtttaa agagagcatg ctgacactgg ggaaggaaag 1320 caagactcca ggaaaaagct ctgttcctct ttacttgatc tatccttctg tggaaaatgt 1380 gcggaccagt ttagaaggat atcctgctgg gggctctctt ccctatagca tccagacagc 1440 tgaaaaacag aattggctgc attcctattt tcacaaatgg tcagctgaga cttctggccg 1500 cagcaatgcc atgccacata ttaagacata tatgaggcct tctccagact tcagtaaaat 1560 tgcttggttc cttgtcacaa gcgcaaatct gtccaaggct gcctggggag cattggagaa 1620 gaatggcacc cagctgatga tccgctccta cgagctcggg gtccttttcc tcccttcagc 1680 atttggtcta gacagtttca aagtgaaaca gaagttcttc gctggcagcc aggagccaat 1740 ggccaccttt cctgtgccat atgatttgcc tccagaactg tatggaagta aagatcggcc 1800 atggatatgg aacattcctt atgtcaaagc accggatacg catgggaaca tgtgggtgcc 1860 ctcctgagaa tcttgaggca ctgtgaaatt taagtgtatg acattgagcc acaaacatgg 1920 aatctcttct ttgtactgga tgtccacttc ccttaaagtc ttatttgcac ccttacaaaa 1980 tctttccaaa ggtcactctt atgaatggat gttggttata cttttaatgg acattaacat 2040 tcctaataaa gtattagttt cttaattc 2068 <210> 209 <211> 1246 <212> DNA <213> Homo sapiens <400> 209 gattatggga ggtggaccat atctagtagt gatgaaagtg aggaagaaaa gccaaaacca 60 gacaagccat ctacctcttc tcttctctgt gccaggcaag gagcagcaaa tgagcccagg 120 tacacctgtt ccgaggccca gaaagctgca cacaagagga aaatatcacc tgtgaaattc 180 agcaatacag attcagtttt acctcccaaa aggcagaaaa gcggttccca ggaggacctc 240 ggctggtgtc tgtccagcag tgatgatgag ctgcaaccag aaatgccgca gaagcaggct 300 gagaaagtgg tgatcaaaaa ggagaaagac atctctgctc ccaatgacgg cactgcccaa 360 agaactgaaa atcatggcgc tcccgcctgc cacaggctca aagaggagga agacgagtat 420 gagacatcag gggagggcca ggacatttgg gacatgctgg ataaagggaa ccccttccag 480 ttttacctca ctagagtctc tggagttaag ccaaagtata actctggagc cctccacatc 540 aaggatattt tatctccttt atttgggacg cttgtttctt cagctcagtt taactactgc 600 tttgacgtgg actggctcgt aaaacagtat ccaccagagt tcaggaagaa gccaatcctg 660 cttgtgcatg gtgataagcg agaggctaag gctcacctcc atgcccaggc caagccttac 720 gagaacatct ctctctgcca ggcaaagttg gatattgcgt ttggaacaca ccacacgaaa 780 atgatgctgc tgctctatga agaaggcctc cgggttgtca tacacacctc caacctcatc 840 catgctgact ggcaccagaa aactcaagga atatggttga gccccttata cccacgaatt 900 gctgatggaa cccacaaatc tggagagtcg ccaacacatt ttaaagctga tctcatcagt 960 tacttgatgg cttataatgc cccttctctc aaggagtgga tagatgtcat tcacaagcac 1020 gatctctctg aaacaaatgt ttatcttatt ggttcaaccc caggacgctt tcaaggaagt 1080 caaaaagata attggggaca ttttagactt aagaagcttc tgaaagacca tgcctcatcc 1140 atgcctaacg cagagtcctg gcctgtcgta ggtcagtttt caagcgttgg ctccttggga 1200 gccgatgaat caaagtggtt atgttctgag tttaaagaga gcatgc 1246 <210> 210 <211> 2210 <212> DNA <213> Homo sapiens <400> 210 gttctgtgcg cctcagagtt ggagcacaca gctgtattaa aaaggcaaat cgaaggccgg 60 gcgcggtgac tcacgcctgt catcctagca ctttgggagg ccgaggcggc tgaatcactt 120 gaggttagga gtttgagatc agcccgggca acatggtgaa accccgtctc tacaaaaata 180 gaaaaattag ccgagcgtga tggtggatgc ctgtaatcct agctcctcgg gaggctaagg 240 agtataatgt ctcaggaagg cgattatggg aggtggacca tatctagtag tgatgaaagt 300 gaggaagaaa agccaaaacc agacaagcca tctacctctt ctcttctctg tgccaggcaa 360 ggagcagcaa atgagcccag gtacacctgt tccgaggccc agaaagctgc acacaagagg 420 aaaatatcac ctgtgaaatt cagcaataca gattcagttt tacctcccaa aaggcagaaa 480 agcggttccc aggaggacct cggctggtgt ctgtccagca gtgatgatga gctgcaacca 540 gaaatgccgc agaagcaggc tgagaaagtg gtgatcaaaa aggagaaaga catctctgct 600 cccaatgacg gcactgccca aagaactgaa aatcatggcg ctcccgcctg ccacaggctc 660 aaagaggagg aagacgagta tgagacatca ggggagggcc aggacatttg ggacatgctg 720 gataaaggga accccttcca gttttacctc actagagtct ctggagttaa gccaaagtat 780 aactctggag ccctccacat caaggatatt ttatctcctt tatttgggac gcttgtttct 840 tcagctcagt ttaactactg ctttgacgtg gactggctcg taaaacagta tccaccagag 900 ttcaggaaga agccaatcct gcttgtgcat ggtgataagc gagaggctaa ggctcacctc 960 catgcccagg ccaagcctta cgagaacatc tctctctgcc aggaaaatga tgctgctgct 1020 ctatgaagaa ggcctccggg ttgtcataca cacctccaac ctcatccatg ctgactggca 1080 ccagaaaact caaggaatat ggttgagccc cttataccca cgaattgctg atggaaccca 1140 caaatctgga gagtcgccaa cacattttaa agctgatctc atcagttact tgatggctta 1200 taatgcccct tctctcaagg agtggataga tgtcattcac aagcacgatc tctctgaaac 1260 aaatgtttat cttattggtt caaccccagg acgctttcaa ggaagtcaaa aagataattg 1320 gggacatttt agacttaaga agcttctgaa agaccatgcc tcatccatgc ctaacgcaga 1380 gtcctggcct gtcgtaggtc agttttcaag cgttggctcc ttgggagccg atgaatcaaa 1440 gtggttatgt tctgagttta aagagagcat gctgacactg gggaaggaaa gcaagactcc 1500 aggaaaaagc tctgttcctc tttacttgat ctatccttct gtggaaaatg tgcggaccag 1560 tttagaagga tatcctgctg ggggctctct tccctatagc atccagacag ctgaaaaaca 1620 gaattggctg cattcctatt ttcacaaatg gtcagctgag acttctggcc gcagcaatgc 1680 catgccacat attaagacat atatgaggcc ttctccagac ttcagtaaaa ttgcttggtt 1740 ccttgtcaca agcgcaaatc tgtccaaggc tgcctgggga gcattggaga agaatggcac 1800 ccagctgatg atccgctcct acgagctcgg ggtccttttc ctcccttcag catttggtct 1860 agacagtttc aaagtgaaac agaagttctt cgctggcagc caggagccaa tggccacctt 1920 tcctgtgcca tatgatttgc ctccagaact gtatggaagt aaagatcggc catggatatg 1980 gaacattcct tatgtcaaag caccggatac gcatgggaac atgtgggtgc cctcctgaga 2040 atcttgaggc actgtgaaat ttaagtgtaa gacattgagc cacaaacatg gaatctcttc 2100 tttgtactgg atgtccactt cccttaaagt cttatttgca cccttacaaa atctttccaa 2160 aggtcactct tatgaatgga tgttggttat acttttaatg gacattaaca 2210 <210> 211 <211> 3043 <212> DNA <213> Homo sapiens <400> 211 aaacttaact cgttgagcgc ggctggaaat ccaagcgctt ctaggtgctg gttcaatgcc 60 tggttcatga tttatttcat tctctccctc catcttgcaa taggttactt ttaatcattt 120 agatctatga cactatgcta aacgttatag gagacaaaaa gactgtgaac aaacaagaag 180 aaccaaacga aaagagccaa gtccaggatt ctcgttcaga tcagcaagtc attgggatcg 240 agctcctagg gcagctacta catctgttat gtcctcaaga taatcccagc acctagcact 300 gtgcctggca caaagtagat cttcaatgaa agaacgaaac gagccgttat atttacacag 360 atgtatttca ctcagtcctc tggaagagat gcctagtgtg aaagagattc caagaataaa 420 taccataaac agcaccgagc ccaaatccca cagcaaacat ccttattaaa ggcaaggaac 480 gtggggcgag ttccttttct cagaagattt tacgagaacg caactgttgc gaagaaggaa 540 cagacattcg aggttctgag tccaatggga actcatttaa ctttttattt tgcagcagat 600 ttcaaagtct gcacccagcc cctcccagga cacaggtctc cttgcagctg cctttaacct 660 aagcgtatcc tctctccact ttaaaccaaa cgccgctgca tggagccctg ggagcctgag 720 ccatgagaat cctgtaaaga ggagttggag cacacagctg tattaaaaag gcaaatcgaa 780 ggccgggcgc ggtgactcac gcctgtcatc ctagcacttt gggaggccga ggcggctgaa 840 tcacttgagg ttaggagttt gagatcagcc cgggcaacat ggtgaaaccc cgtctctaca 900 aaaatagaaa aattagccga gcgtgatggt ggatgcctgt aatcctagct cctcgggagg 960 ctaaggagta taatgtctca ggaaggcgat tatgggaggt ggaccatatc tagtagtgat 1020 gaaagtgagg aagaaaagcc aaaaccagac aagccatcta cctcttctct tctctgtgcc 1080 aggcaaggag cagcaaatga gcccaggtac acctgttccg aggcccagaa agctgcacac 1140 aagaggaaaa tatcacctgt gaaattcagc aatacagatt cagttttacc tcccaaaagg 1200 cagaaaagcg gttcccagga ggacctcggc tggtgtctgt ccagcagtga tgatgagctg 1260 caaccagaaa tgccgcagaa gcaggctgag aaagtggtga tcaaaaagga gaaagacatc 1320 tctgctccca atgacggcac tgcccaaaga actgaaaatc atggcgctcc cgcctgccac 1380 aggctcaaag aggaggaaga cgagtatgag acatcagggg agggccagga catttgggac 1440 atgctggata aagggaaccc cttccagttt tacctcacta gagtctctgg agttaagcca 1500 aagtataact ctggagccct ccacatcaag ggacagtctt atgagtagat gttacaatcg 1560 tattccttgg ataaatgatg catctgcact ttagaaaagt gcccaaggtc gtagagctga 1620 tagtttatct cctttatttg ggacgcttgt ttcttcagct cagtttaact actgctttga 1680 cgtggactgg ctcgtaaaac agtatccacc agagttcagg aagaagccaa tcctgcttgt 1740 gcatggtgat aagcgagagg ctaaggctca cctccatgcc caggccaagc cttacgagaa 1800 catctctctc tgccaggcaa agttggatat tgcgtttgga acacaccaca cgaaaatgat 1860 gctgctgctc tatgaagaag gcctccgggt tgtcatacac acctccaacc tcatccatgc 1920 tgactggcac cagaaaactc aagggttcgt aggggcctgc tcacttcctg gcagtgtgtg 1980 tgttgataaa gaatatggtt gagcccctta tacccacgaa ttgctgatgg aacccacaaa 2040 tctggagagt cgccaacaca ttttaaagct gatctcatca gttacttgat ggcttataat 2100 gccccttctc tcaaggagtg gatagatgtc attcacaagc acgatctctc tgaaacaaat 2160 gtttatctta ttggttcaac cccaggacgc tttcaaggaa gtcaaaaaga taattgggga 2220 cattttagac ttaagaagct tctgaaagac catgcctcat ccatgcctaa cgcagagtcc 2280 tggcctgtcg taggtcagtt ttcaagcgtt ggctccttgg gagccgatga atcaaagtgg 2340 ttatgttctg agtttaaaga gagcatgctg acactgggga aggaaagcaa gactccagga 2400 aaaagctctg ttcctcttta cttgatctat ccttctgtgg aaaatgtgcg gaccagttta 2460 gaaggatatc ctgctggggg ctctcttccc tatagcatcc agacagctga aaaacagaat 2520 tggctgcatt cctattttca caaatggtca gctgagactt ctggccgcag caatgccatg 2580 ccacatatta agacatatat gaggccttct ccagacttca gtaaaattgc ttggttcctt 2640 gtcacaagcg caaatctgtc caaggctgcc tggggagcat tggagaagaa tggcacccag 2700 ctgatgatcc gctcctacga gctcggggtc cttttcctcc cttcagcatt tggtctagac 2760 agtttcaaag tgaaacagaa gttcttcgct ggcagccagg agccaatggc cacctttcct 2820 gtgccatatg atttgcctcc agaactgtat ggaagtaaag atcggccatg gatatggaac 2880 attccttatg tcaaagcacc ggatacgcat gggaacatgt gggtgccctc ctgagaatct 2940 tgaggcactg tgaaatttaa gtgtaagaca ttgagccaca aacatggaat ctcttctttg 3000 tactggatgt ccacttccct taaagtctta tttgcaccct tac 3043 <210> 212 <211> 2504 <212> DNA <213> Homo sapiens <400> 212 ccattctccg cagagttgga gcacacagct gtattaaaaa ggcaaatcga aggccgggcg 60 cggtgactca cgcctgtcat cctagcactt tgggaggccg aggcggctga atcacttgag 120 gttaggagtt tgagatcagc ccgggcaaca tggtgaaacc ccgtctctac aaaaatagaa 180 aaattagccg agcgtgatgg tggatgcctg taatcctagc tcttcgggag gctaaggagt 240 ataatgtctc aggaaggcga ttatgggagg tggaccatat ctagtagtga tgaaagtgag 300 gaagaaaagc caaaaccaga caagccatct acctcttctc ttctctgtgc caggcaagga 360 gcagcaaatg agcccaggta cacctgttcc gaggcccaga aagctgcaca caagaggaaa 420 atatcacctg tgaaattcag caatacagat tcagttttac ctcccaaaag gcagaaaagc 480 ggttcccagg aggacctcgg ctggtgtctg tccagcagtg atgatgagct gcaaccagaa 540 atgccgcaga agcaggctga gaaagtggtg atcaaaaagg agaaagacat ctctgctccc 600 aatgacggca ctgcccaaag aactgaaaat catggcgctc ccgcctgcca caggctcaaa 660 gaggaggaag acgagtatga gacatcaggg gagggccagg acatttggga catgctggat 720 aaagggaacc ccttccagtt ttacctcact agagtctctg gagttaagcc aaagtataac 780 tctggagccc tccacatcaa ggatatttta tctcctttat ttgggacgct tgtttcttca 840 gctcagttta actactgctt tgacgtggac tggctcgtaa aacagtatcc accagagttc 900 aggaagaagc caatcctgct tgtgcatggt gataagcgag aggctaaggc tcacctccat 960 gcccaggcca agccttacga gaacatctct ctctgccagg caaagttgga tattgcgttt 1020 ggaacacacc acacgaaaat gatgctgctg ctctatgaag aaggcctccg ggttgtcata 1080 cacacctcca acctcatcca tgctgactgg caccagaaaa ctcaaggaac tcacctgtga 1140 gtgaatctct gatccaggag gagcctcact cagcctggga actttgaggt gctattgcaa 1200 ggggaggtcc tccacgtctg tccagcccaa cctggtcatt ttacacacgg aggcaaaggc 1260 ccagagagat cacagagctt acccaaaatg aatatggttg agccccttat acccacgaat 1320 tgctgatgga acccacaaat ctggagagtc gccaacacat tttaaagctg atctcatcag 1380 ttacttgatg gcttataatg ccccttctct caaggagtgg atagatgtca ttcacaagca 1440 cgatctctct gaaacaaatg tttatcttat tggttcaacc ccaggacgct ttcaaggaag 1500 tcaaaaagat aattggggac attttagact taagaagctt tgcataatta tcaaagcagg 1560 aaatgcagat cagtcttctg cagtgtttta gctgcttctg aaagaccatg cctcatccat 1620 gcctaacgca gagtcctggc ctgtcgtagg tcagttttca agcgttggct ccttgggagc 1680 cgatgaatca aagtggttat gttctgagtt taaagagagc atgctgacac tggggaagga 1740 aagcaagact ccaggaaaaa gctctgttcc tctttacttg atctatcctt ctgtggaaaa 1800 tgtgcggacc agtttagaag gatatcctgc tgggggctct cttccctata gcatccagac 1860 agctgaaaaa cagaattggc tgcattccta ttttcacaaa tggtcagctg agacttctgg 1920 ccgcagcaat gccatgccac atattaagac atatatgagg ccttctccag acttcagtaa 1980 aattgcttgg ttccttgtca caagcgcaaa tctgtccaag gctgcctggg gagcattgga 2040 gaagaatggc acccagctga tgatccgctc ctacgagctc ggggtccttt tcctcccttc 2100 agcatttggt ctagacagtt tcaaagtgaa acagaagttc ttcgctggca gccaggagcc 2160 aatggccacc tttcctgtgc catatgattt gcctccagaa ctgtatggaa gtaaagatcg 2220 gccatggata tggaacattc cttatgtcaa agcaccggat acgcatggga acatgtgggt 2280 gccctcctga gaatcttgag gcactgtgaa atttaagtgt aagacattga gccacaaaca 2340 tggaatctct tctttgtact ggatgtccac ttcccttaaa gtcttatttg cacccttaca 2400 aaatctttcc aaaggtcact cttatgaatg gatgttggtt atacttttaa tggacattaa 2460 cattcctaat aaagtattag tttcttaaaa aaaaaaaaaa aaaa 2504 <210> 213 <211> 1187 <212> DNA <213> Homo sapiens <400> 213 tggtgccagt cagcatggat gaggttggag gtgtgtatga caacccggag gccttcttca 60 tagagcagca gcatcatttt cgtgtggtgt gttccaaacg ctttcaagga agtcaaaaag 120 ataattgggg acattttaga cttaagaagc ttctgaaaga ccatgcctca tccatgccta 180 acgcagagtc ctggcctgtc gtaggtcagt tttcaagcgt tggctccttg ggagccgatg 240 aatcaaagtg gttatgttct gagtttaaag agagcatgct gacactgggg aaggaaagca 300 agactccagg aaaaagctct gttcctcttt acttgatcta tccttctgtg gaaaatgtgc 360 ggaccagttt agaaggatat cctgctgggg gctctcttcc ctatagcatc cagacagctg 420 aaaaacagaa ttggctgcat tcctattttc acaaatggtc agctgagact tctggccgca 480 gcaatgccat gccacatatt aagacatata tgaggccttc tccagacttc agtaaaattg 540 cttggttcct tgtcacaagc gcaaatctgt ccaaggctgc ctggggagca ttggagaaga 600 atggcaccca gctgatgatc cgctcctacg agctcggggt ccttttcctc ccttcagcat 660 ttggtctaga cagtttcaaa gtgaaacaga agttcttcgc tggcagccag gagccaatgg 720 ccacctttcc tgtgccatat gatttgcctc cagaactgta tggaagtaaa ggtgagacac 780 agataaagga aaaccacggg tggatatgca taagaaaaac aaacagagcc caggagaagc 840 ctttggtctc agtgggatcc tggctcatgg aaccctctgg aagctcaagt ttgcagaggg 900 ccctttgcca gcctgtctgg ggccttgtag ccactggtta gtcttggaat ccctttgcac 960 tcctataatt actatacaga tccttcctga cttacactgg ggctacatgc tgataaaccc 1020 ctcatgaatt gaaaatatca taagtcaaaa atgcatttaa tgcgtcaaat ctactgagca 1080 ccatagctta gtctagccta ccctaaacat gatcagacct cttaaattag tctacacttg 1140 ggcaaaataa atcaaagact gttttataac aaaaaaaaaa aaaaaaa 1187 <210> 214 <211> 798 <212> DNA <213> Homo sapiens <400> 214 gcatgctgac actggggaag gaaagcaaga ctccaggaaa aagctctgtt cctctttact 60 tgatctatcc ttctgtggaa aatgtgcgga ccagtttaga aggatatcct gctgggggct 120 ctcttcccta tagcatccag acagctgaaa aacagaattg gctgcattcc tattttcaca 180 aatggtcagc tgagacttct ggccgcagca atgccatgcc acatattaag acatatatga 240 ggccttctcc agacttcagt aaaattgctt ggttccgtgt cacaagcgca aatctgtcca 300 aggctgcctg gggagcattg gagaagaatg gcacccagct gatgatccgc tcctacgagc 360 tcggggtcct tttcctccct tcagcatttg gtctagacag tttcaaagtg aaacagaagt 420 tcttcgctgg cagccaggag ccaatggcca cctttcctgt gccatatgat ttgcctccag 480 aactgtatgg aagtaaagat cggccatgga tatggaacat tccttatgtc aaagcaccgg 540 atacgcatgg gaacatgtgg gtgccctcct gagaatcttg aggcactgtg aaatttaagt 600 gtaagacatt gagccacaaa catggaatct cttctttgta ctggatgtcc acttccctta 660 aagtcttatt tgcaccctta caaaatcttt ccaaaggtca ctcttatgaa tggatgttgg 720 ttatactttt aatggacatt aacattccta ataaagtatt agtttcttaa aaaaaaaaaa 780 aaaaaaaaaa aaaaaaaa 798 <210> 215 <211> 2107 <212> DNA <213> Homo sapiens <400> 215 gtgcggacca gtttagaagg atatcctgct gggggctctc ttccctatag catccagaca 60 gctgaaaaac agaattggct gcattcctat tttcacaaat ggtcagctga gacttctggc 120 cgcagcaatg ccatgccaca tattaagaca tatatgaggc cttctccaga cttcagtaaa 180 attgcttggt tccttgtcac aagcgcaaat ctgtccaagg ctgcctgggg agcattggag 240 aagaatggca cccagctgat gatccgctcc tacgagctcg gggtcctttt cctcccttca 300 gcatttggtc tagacagttt caaagtgaaa cagaagttct tcgctggcag ccaggagcca 360 atggccacct ttcctgtgcc atatgatttg cctccagaac tgtatggaag taaagatcgg 420 ccatggatat ggaacattcc ttatgtcaaa gcaccggata cgcatgggaa catgtgggtg 480 ccctcctgag aatcttgagg cactgtgaaa tttaagtgta agacattgag ccacaaacat 540 ggaatctctt ctttgtactg gatgtccact tcccttaaag tcttatttgc acccttacaa 600 aatctttcca aaggtcactc ttatgaatgg atgttggtta tacttttaat ggacattaac 660 attcctaata aagtattagt ttcttaattc acttttatat gttttggaaa gaaaattagt 720 gaacttctct atgttaaaaa tacgtactgc ttgagtatcc cctgtctgaa atgcttggga 780 ccagaagtgt ttcagctttt ggattttttt gaattttgga atatttgcat agcataatga 840 gatatcttgg gaatgggacc caaatctaaa cacaaaattc atttatgttt catatacacc 900 ttatatacaa taacctaaag gtgattttat atgatatttt gagtaatttt atgcatgaaa 960 caaagttttg acaggctttt gaccgtgatt catcacatga gttcaggcat ggaaattttc 1020 atttggagca tcatgtcagc actcaaaaag ttctggatct tggagcagtt cagattttca 1080 gattagggat gctcaaatct atatagatat aaaattatcc tcacagtaac atagaatctc 1140 ttggtgctgt cagctgttgg gaattgaaga ttgactttgt gcttccaccc tccatccaga 1200 aaggcaccct tcattccacc agaactttac ccaggaagaa cacgatcatt tcctttttca 1260 ccgatgccct ctctcagctt tctgagtacg tctcttgggg tcgctggagg tgatcctagg 1320 atctgtctct gagaccaatg tgctgtttca gccccctgca gctaagaatt gtattgactg 1380 tcctcacagc ggcttttcat agctttcagc ttcagcttta cgaggcttct cctctctccc 1440 tggcaccctg ctggctgcct cactgcttac agacaggtcc caccaaaccc aaacacctgc 1500 ctagggtgaa tgggtctctc ttctatcccc agaaactttc agaggaagca gctcatagaa 1560 acatacaaaa gcacacaagt attttgggaa aaaatcctaa aaggtgactt aatttgatgc 1620 cttaaattca caagtgagga agctaaggcc tagaaggtta aggatgtccc cagggtcaca 1680 cagtgagcgg ggctcagagc ttgagtgtct ttgtgctttg tgtacattgt gttctcccta 1740 gggtgcttta gaccctgttt gttttcttct gcatgaggct gatttccagt ttgtcatcaa 1800 cctctttatc ttataattta ggatagagtt gaacgttagt cttgaaagat tttctaaagt 1860 agtctttcaa actgttcctc agaggcctag gattttccaa aagtacctta ggaaccttgt 1920 aggctgcagt gggggtgtgg cgatagagca ggaggcaggg agacagggct gcagggcctc 1980 ccaccttcca acagacaggc tctgctgtat ctgttgtaca tactgggatt ctgtaaagga 2040 cattatctgg ggtgttgtat gtatttttgt gtgttctgct tttttaaata aacttgaaaa 2100 gctactg 2107 <210> 216 <211> 3098 <212> DNA <213> Homo sapiens <400> 216 cgggaggttc ggagcgggag ctcgggctcg cggacggtat ggaggactac gagcaggagc 60 tgtgcggcgt cgaggatgat ttccacaacc agttcgcggc cgagctggag gtgctggcag 120 agctggaagg ggcgtcgact ccgtcgccct ccggggtccc cctgttcacc gcgggccgac 180 ccccgcggac gttcgaggag gcccttgcca gaggggacgc ggcctccagt cccgccccag 240 ccgcatctgt gggcagcagc cagggcggcg ccaggaagag gcaggtggac gccgacctgc 300 agccggccgg gtccctgccc cacgccccca ggatcaaacg gcctaggctg caggtggtca 360 agaggctgaa cttcaggtcg gaggagatgg aggagccgcc ccctcccgac tcctcgccga 420 cggacatcac cccgccgccg agccctgagg acctcgcaga gctttggggc cacggagtct 480 cagaagctgc tgccgacgtg ggtctcacac gggcctcacc agctgcccgc aatcccgtcc 540 tgaggcggcc ccccatcttg gaggactacg tccacgtgac atccacggag ggcgtccggg 600 cttatctggt gctgcgtgct gaccccatgg ccccgggggt gcagggctct ctcctccacg 660 tcccatggcg aggcggtggc cagctggacc tgctgggtgt gtccttagcc tccctgaaga 720 agcaggtcga cggcgagcgg cgggagcggc tgcttcagga ggcccagaag ctttcagaca 780 ccctgcacag tctcaggtcg ggggaggagg aggcagccca gcccttgggg gcccctgagg 840 aggagccgac tgacggtcaa gacgcctcca gtcactgcct ctgggtggat gagtttgcac 900 cccgccacta cacggagctg ctcagtgatg acttcaccaa ccgctgcctg ctcaagtggc 960 tgaagttgtg ggacctggtg gtgtttggcc acgagaggcc ttcccggaag cccaggccca 1020 gtgttgagcc ggcccgggtc agcaaggagg ccacagcccc aggcaagtgg aagagccacg 1080 aacaggtgct ggaggagatg ctggaggctg ggctggaccc gagccagcga ccgaagcaga 1140 aggtggcact gctctgtggg cccccggggc tggggaagac caccctggca cacgtgattg 1200 cgcgtcacgc ggggtactct gtggtggaga tgaacgccag tgacgaccgt agcccggagg 1260 tcttccgcac acgcatcgag gcggccaccc agatggagtc ggtgctgggt gctggcggga 1320 agcccaactg cctggtcatc gatgagatcg acggggcccc cgtggccgcc atcaacgtcc 1380 tcctgagcat cctgaaccgc aaggggccac aggaggtggg gccacagggc ccggctgtgc 1440 cttcgggagg cggccgacgg cgccgggcag agggggggct cctcatgagg cccattatct 1500 gcatttgcaa tgaccagttc gcaccgtccc tgcggcagct gaagcagcag gccttcctgc 1560 tccacttccc gccgactctg ccctcgaggc tggtgcagcg gctccaggag gtctccctgc 1620 ggcagggcat gagggccgac ccaggggtgc tggccgccct ctgtgagaaa actgacaatg 1680 acatccgggc ctgcatcaac accctgcagt tcctgtacag ccggggccag cgggagctga 1740 gcgtgcggga cgtgcaggcc acacgcgtgg gcctcaagga ccagcgcaga gggctcttct 1800 cggtgtggca ggaggtcttc cagctgcctc gagcccagag gcgccgtgtg ggccaggacc 1860 ccgccctgcc tgctgacaca ctcctgctgg gtgacgggga cgcgggctcc ctcacctccg 1920 cctcacagcg attctaccgt gtcctgcatg ccgctgcctc tgcgggcgag cacgagaagg 1980 tggtccaggg cttgtttgac aacttcctgc gtctgcggct gcgagactcc agcctgggtg 2040 ctgtgtgtgt ggccctcgac tggctggcct tcgatgacct gctggcgggg gctgctcatc 2100 acagccagag cttccagctg ctgcgctacc cacccttcct gcccgtggcc ttccatgtgc 2160 tgtttgcttc cagccacaca cccaggatca ccttccccag cagccagcag gaggcccaga 2220 accggatgag ccagatgagg aacctgatcc agacgctggt gtccggcatc gcgccagcca 2280 cgcgcagccg ggccacgccc caggccctgc tcctcgatgc cctctgcctg ctcctggaca 2340 ttcttgcacc caagctccgc cccgtgagca cacagctgta cagcacccgt gaaaagcaac 2400 agctggccag cctggtgggc acgatgctcg cttacagcct gacctaccgc caggagcgca 2460 cgcccgatgg ccagtacatc tacaggctgg agccgaacgt ggaggaactc tgccgcttcc 2520 ctgagctgcc tgcccgcaag cccctcacct accagacgaa gcagctcatc gcccgcgaga 2580 tcgaggtgga gaagatgcgg cgggcggagg cttctgcccg ggtagagaac agcccccagg 2640 tggatgggag ccccccaggg ctcgagggtc tgctgggggg cattggggag aaaggggtgc 2700 accgacctgc cccacgcaac catgagcagc ggctggagca catcatgagg cgagcggccc 2760 gggaggaaca gcctgagaag gacttctttg gacgtgtggt cgtcaggagc acagcagtcc 2820 cgagtgcagg ggacacggcc ccggagcagg actcagtgga gcggcgcatg ggcacagcgg 2880 tgggcaggag cgaggtctgg ttccgcttca acgagggtgt ttccaacgcc gtgcggcgca 2940 gcctgtacat cagggacttg ctttagtttt ttgagccgcg gacatgccct cgcattgctt 3000 cccgcagagt gcagagacag gaagctggag atgtctttat aaagtcacac ctttacaggc 3060 tgtaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa 3098 <210> 217 <211> 3098 <212> DNA <213> Homo sapiens <400> 217 cgggaggttc ggagcgggag ctcgggctcg cggacggtat ggaggactac gagcaggagc 60 tgtgcggcgt cgaggatgat ttccacaacc agttcgcggc cgagctggag gtgctggcag 120 agctggaagg ggcgtcgact ccgtcgccct ccggggtccc cctgttcacc gcgggccgac 180 ccccgcggac gttcgaggag gcccttgcca gaggggacgc ggcctccagt cccgccccag 240 ccgcatctgt gggcagcagc cagggcggcg ccaggaagag gcaggtggac gccgacctgc 300 agccggccgg gtccctgccc cacgccccca ggatcaaacg gcctaggctg caggtggtca 360 agaggctgaa cttcaggtcg gaggagatgg aggagccgcc ccctcccgac tcctcgccga 420 cggacatcac cccgccgccg agccctgagg acctcgcaga gctttggggc cacggagtct 480 cagaagctgc tgccgacgtg ggtctcacac gggcctcacc agctgcccgc aatcccgtcc 540 tgaggcggcc ccccatcttg gaggactacg tccacgtgac atccacggag ggcgtccggg 600 cttatctggt gctgcgtgct gaccccatgg ccccgggggt gcagggctct ctcctccacg 660 tcccatggcg aggcggtggc cagctggacc tgctgggtgt gtccttagcc tccctgaaga 720 agcaggtcga cggcgagcgg cgggagcggc tgcttcagga ggcccagaag ctttcagaca 780 ccctgcacag tctcaggtcg ggggaggagg aggcagccca gcccttgggg gcccctgagg 840 aggagccgac tgacggtcaa gacgcctcca gtcactgcct ctgggtggat gagtttgcac 900 cccgccacta cacggagctg ctcagtgatg acttcaccaa ccgctgcctg ctcaagtggc 960 tgaagttgtg ggacctggtg gtgtttggcc acgagaggcc ttcccggaag cccaggccca 1020 gtgttgagcc ggcccgggtc agcaaggagg ccacagcccc aggcaagtgg aagagccacg 1080 aacaggtgct ggaggagatg ctggaggctg ggctggaccc gagccagcga ccgaagcaga 1140 aggtggcact gctctgtggg cccccggggc tggggaagac caccctggca cacgtgattg 1200 cgcgtcacgc ggggtactct gtggtggaga tgaacgccag tgacgaccgt agcccggagg 1260 tcttccgcac acgcatcgag gcggccaccc agatggagtc ggtgctgggt gctggcggga 1320 agcccaactg cctggtcatc gatgagatcg acggggcccc cgtggccgcc atcaacgtcc 1380 tcctgagcat cctgaaccgc aaggggccac aggaggtggg gccacagggc ccggctgtgc 1440 cttcgggagg cggccgacgg cgccgggcag agggggggct cctcatgagg cccattatct 1500 gcatttgcaa tgaccagttc gcaccgtccc tgcggcagct gaagcagcag gccttcctgc 1560 tccacttccc gccgactctg ccctcgaggc tggtgcagcg gctccaggag gtctccctgc 1620 ggcagggcat gagggccgac ccaggggtgc tggccgccct ctgtgagaaa actgacaatg 1680 acatccgggc ctgcatcaac accctgcagt tcctgtacag ccggggccag cgggagctga 1740 gcgtgcggga cgtgcaggcc acacgcgtgg gcctcaagga ccagcgcaga gggctcttct 1800 cggtgtggca ggaggtcttc cagctgcctc gagcccagag gcgccgtgtg ggccaggacc 1860 ccgccctgcc tgctgacaca ctcctgctgg gtgacgggga cgcgggctcc ctcacctccg 1920 cctcacagcg attctaccgt gtcctgcatg ccgctgcctc tgcgggcgag cacgagaagg 1980 tggtccaggg cttgtttgac aacttcctgc gtctgcggct gcgagactcc agcctgggtg 2040 ctgtgtgtgt ggccctcgac tggctggcct tcgatgacct gctggcgggg gctgctcatc 2100 acagccagag cttccagctg ctgcgctacc cacccttcct gcccgtggcc ttccatgtgc 2160 tgtttgcttc cagccacaca cccaggatca ccttccccag cagccagcag gaggcccaga 2220 accggatgag ccagatgagg aacctgatcc agacgctggt gtccggcatc gcgccagcca 2280 cgcgcagccg ggccacgccc caggccctgc tcctcgatgc cctctgcctg ctcctggaca 2340 ttcttgcacc caagctccgc cccgtgagca cacagctgta cagcacccgt gaaaagcaac 2400 agctggccag cctggtgggc acgatgctcg cttacagcct gacctaccgc caggagcgca 2460 cgcccgatgg ccagtacatc tacaggctgg agccgaacgt ggaggaactc tgccgcttcc 2520 ctgagctgcc tgcccgcaag cccctcacct accagacgaa gcagctcatc gcccgcgaga 2580 tcgaggtgga gaagatgcgg cgggcggagg cttctgcccg ggtagagaac agcccccagg 2640 tggatgggag ccccccaggg ctcgagggtc tgctgggggg cattggggag aaaggggtgc 2700 accgacctgc cccacgcaac catgagcagc ggctggagca catcatgagg cgagcggccc 2760 gggaggaaca gcctgagaag gacttctttg gacgtgtggt cgtcaggagc acagcagtcc 2820 cgagtgcagg ggacacggcc ccggagcagg actcagtgga gcggcgcatg ggcacagcgg 2880 tgggcaggag cgaggtctgg ttccgcttca acgagggtgt ttccaacgcc gtgcggcgca 2940 gcctgtacat cagggacttg ctttagtttt ttgagccgcg gacatgccct cgcattgctt 3000 cccgcagagt gcagagacag gaagctggag atgtctttat aaagtcacac ctttacaggc 3060 tgtaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa 3098 <210> 218 <211> 3086 <212> DNA <213> Homo sapiens <400> 218 ggcacgaggt cggagcggga gctcgggctc gcggacggta tggaggacta cgagcaggag 60 ctgtgcggcg tcgaggatga tttccacaac cagttcgcgg ccgagctgga ggtgctggca 120 gagctggaag gggcgtcgac tccgtcgccc tccggggtcc ccctgttcac cgcgggccga 180 cccccgcgga cgttcgagga ggcccttgcc agaggggacg cggcctccag tcccgcccca 240 gccgcatctg tgggcagcag ccagggcggc gccaggaaga ggccggtgga cgccgacctg 300 cagccggccg ggtccctgcc ccacgccccc aggatcaaac ggcctaggct gcaggtggtc 360 aagaggctga acttcaggtc ggaggagatg gaggagccgc cccctcccga ctcctcgccg 420 acggacatca ccccgccgcc gagccctgag gacctcgcag agctttgggg ccacggagtc 480 tcagaagctg ctgccgacgt gggtctcaca cgggcctcac cagctgcccg caatcccgtc 540 ctgaggcggc cccccatctt ggaggactac gtccacgtga catccacgga gggcgtccgg 600 gcttatctgg tgctgcgtgc tgaccccatg gccccggggg tgcagggctc tctcctccac 660 gtcccatggc gaggcggtgg ccagctggac ctgctgggtg tgtccttagc ctccctgaag 720 aagcaggtcg acggcgagcg gcgggagcgg ctgcttcagg aggcccagag gctttcagac 780 accctgcaca gtctcaggtc gggggaggag gaggcagccc agcccttggg ggcccctgag 840 gaggagccga ctgacggtca agacgcctcc agtcactgcc tctgggtgga tgagtttgca 900 ccgcgccact acacggagct gctcagtgat gacttcacca accgctgcct gctcaagtgg 960 ctgaagttgt gggacctggt ggtgtttggc cacgagaggc cttcccggaa gcccaggccc 1020 agtgttgagc cggcccgggt cagcaaggag gccacagccc caggcaagtg gaagagccac 1080 gaacaggtgc tggaggagat gctggaggct gggctggacc cgagccagcg accgaagcag 1140 aaggtggcac tgctctgtgg gcccccgggg ctggggaaga ccaccctggc acacgtgatt 1200 gcgcgtcacg cggggtactc tgtggtggag atgaacgcca gtgacgaccg tagcccggag 1260 gtcttccgca cacgcatcga ggcggccacc cagatggagt cggtgctggg tgctggcggg 1320 aagcccaact gcctggtcat cgatgagatc gacggggccc ccgtggccgc catcaatgtc 1380 ctcctgagca tcctgaaccg caaggggcca caggaggtgg ggccacaggg cccggctgtg 1440 ccttcgggag gcggccgacg gcgccgggca gagggggggc tcctcatgag gcccattatc 1500 tgcatttgca atgaccagtt cgcaccgtcc ctgcggcagc tgaagcagca ggccttcctg 1560 ctccacttcc cgccgactct gccctcgagg ctggtgcagc ggctccagga ggtctccctg 1620 cggcagggca tgagggccga cccaggggtg ctggccgccc tctgtgagaa aactgacaat 1680 gacatccggg cctgcatcaa caccctgcag ttcctgtaca gccggggcca gcgggagctg 1740 agcgtgcggg acgtgcaggc cacacgcgtg ggcctcaagg accagcgcag agggctcttc 1800 tcggtgtggc aggaggtctt ccagctgcct cgagcccaga ggcgccgtgt gggccaggac 1860 cccgccctgc ctgctgacac actcctgctg ggtgacgggg acgcgggctc cctcacctcc 1920 gcctcacagc gattctaccg tgtcctgcat gccgctgcct ctgcgggcga gcacgagaag 1980 gtggtccagg gcttgtttga caacttcctg cgtctgcggc tgcgagactc cagcctgggt 2040 gctgtgtgtg tggccctcga ctggctggcc ttcgatgacc tgctggcggg ggctgctcat 2100 cacagtcaga gcttccagct gctgcgctac ccacccttcc tgcccgtggc cttccatgtg 2160 ctgtttgctt ccagccacac acccaggatc accttcccca gcagccagca ggaggcccag 2220 aaccggatga gccagatgag gaacctgatc cagacgctgg tgtccggcat cgcgccagcc 2280 acgcgcagcc gggccacgcc ccaggccctg ctcctcgatg ccctctgcct gctcctggac 2340 attcttgcac ccaagctccg ccccgtgagc acacagctgt acagcacccg tgaaaagcaa 2400 cagctggcca gcctggtggg cacgatgctc gcttacagcc tgacctaccg ccaggagcgc 2460 acgcccgatg gccagtacat ctacaggctg gagccgaacg tggaggaact ctgccgcttc 2520 cctgagctgc ctgcccgcaa gcccctcacc taccagacga agcagctcat cgcccgcgag 2580 atcgaggtgg agaagatgcg gcgggcggag gcttctgccc gggtagagaa cagcccccag 2640 gtggatggga gccccccagg gctcgagggt ctgctggggg gcattgggga gaaaggggtg 2700 caccgacctg ccccacgcaa ccatgagcag cggctggagc acatcatgag gcgagcggcc 2760 cgggaggaac agcctgagaa ggacttcttt ggacgtgtgg tcgtcaggag cacagcagtc 2820 ctgagtgcag gggacacggc cccggagcag gactcagtgg agcggcgcat gggcacagcg 2880 gtgggcagga gcgaggtctg gttccgcttc aacgagggtg tctccaacgc cgtgcggcgc 2940 agcctgtaca tcagggactt gctctagttc tctgagccgc ggacatgccc tcgcattgct 3000 tcccgcagag tgcagagaca ggaagctgga gatgtcttta taaagtcaca cctttacaga 3060 ctgtaaaaaa aaaaaaaaaa aaaaaa 3086 <210> 219 <211> 3166 <212> DNA <213> Homo sapiens <400> 219 gcgggaggtt cggagcggga gctcgggctc gcggacggta tggaggacta cgagcaggag 60 ctgtgcggcg tcgaggatga tttccacaac cagttcgcgg ccgagctgga ggtgctggca 120 gagctggaag gggcgtcgac tccgtcgccc tccggggtcc ccctgttcac cgcgggccga 180 cccccgcgga cgttcgagga ggcccttgcc agaggggacg cggcctccag tcccgcccca 240 gccgcatctg tgggcagcag ccagggcggc gccaggaaga ggcaggtgga cgccgacctg 300 cagccggccg ggtccctgcc ccacggtagg ttggcggcat tgccccaggg cctccggagt 360 gggcgcgagg ctgaggaggc ctctggttcc ctgcatgtgt ctcccccagc ccccaggatc 420 aaacggccta ggctgcaggt ggtcaagagg ctgaacttca ggtcggagga gatggaggag 480 ccgccccctc ccgactcctc gccgacggac atcaccccgc cgccgagccc tgaggacctc 540 gcagagcttt ggggccacgg agtctcagaa gctgctgccg acgtgggtct cacacgggcc 600 tcaccagctg cccgcaatcc cgtcctgagg cggcccccca tcttggagga ctacgtccac 660 gtgacatcca cggagggcgt ccgggcttat ctggtgctgc gtgctgaccc catggccccg 720 ggggtgcagg gctctctcct ccacgtccca tggcgaggcg gtggccagct ggacctgctg 780 ggtgtgtcct tagcctccct gaagaagcag gtcgacggcg agcggcggga gcggctgctt 840 caggaggccc agaagctttc agacaccctg cacagtctca ggtcggggga ggaggaggca 900 gcccagccct tgggggcccc tgaggaggag ccgactgacg gtcaagacgc ctccagtcac 960 tgcctctggg tggatgagtt tgcaccccgc cactacacgg agctgctcag tgatgacttc 1020 accaaccgct gcctgctcaa gtggctgaag ttgtgggacc tggtggtgtt tggccacgag 1080 aggccttccc ggaagcccag gcccagtgtt gagccggccc gggtcagcaa ggaggccaca 1140 gccccaggca agtggaagag ccacgaacag gtgctggagg agatgctgga ggctgggctg 1200 gacccgagcc agcgaccgaa gcagaaggtg gcactgctct gtgggccccc ggggctgggg 1260 aagaccaccc tggcacacgt gattgcgcgt cacgcggggt actctgtggt ggagatgaac 1320 gccagtgacg accgtagccc ggaggtcttc cgcacacgca tcgaggcggc cacccagatg 1380 gagtcggtgc tgggtgctgg cgggaagccc aactgcctgg tcatcgatga gatcgacggg 1440 gcccccgtgg ccgccatcaa cgtcctcctg agcatcctga accgcaaggg gccacaggag 1500 gtggggccac agggcccggc tgtgccttcg ggaggcggcc gacggcgccg ggcagagggg 1560 gggctcctca tgaggcccat tatctgcatt tgcaatgacc agttcgcacc gtccctgcgg 1620 cagctgaagc agcaggcctt cctgctccac ttcccgccga ctctgccctc gaggctggtg 1680 cagcggctcc aggaggtctc cctgcggcag ggcatgaggg ccgacccagg ggtgctggcc 1740 gccctctgtg agaaaactga caatgacatc cgggcctgca tcaacaccct gcagttcctg 1800 tacagccggg gccagcggga gctgagcgtg cgggacgtgc aggccacacg cgtgggcctc 1860 aaggaccagc gcagagggct cttctcggtg tggcaggagg tcttccagct gcctcgagcc 1920 cagaggcgcc gtgtgggcca ggaccccgcc ctgcctgctg acacactcct gctgggtgac 1980 ggggacgcgg gctccctcac ctccgcctca cagcgattct accgtgtcct gcatgccgct 2040 gcctctgcgg gcgagcacga gaaggtggtc cagggcttgt ttgacaactt cctgcgtctg 2100 cggctgcgag actccagcct gggtgctgtg tgtgtggccc tcgactggct ggccttcgat 2160 gacctgctgg cgggggctgc tcatcacagc cagagcttcc agctgctgcg ctacccaccc 2220 ttcctgcccg tggccttcca tgtgctgttt gcttccagcc acacacccag gatcaccttc 2280 cccagcagcc agcaggaggc ccagaaccgg atgagccaga tgaggaacct gatccagacg 2340 ctggtgtccg gcatcgcgcc agccacgcgc agccgggcca cgccccaggc cctgctcctc 2400 gatgccctct gcctgctcct ggacattctt gcacccaagc tccgccccgt gagcacacag 2460 ctgtacagca cccgtgaaaa gcaacagctg gccagcctgg tgggcacgat gctcgcttac 2520 agcctgacct accgccagga gcgcacgccc gatggccagt acatctacag gctggagccg 2580 aacgtggagg aactctgccg cttccctgag ctgcctgccc gcaagcccct cacctaccag 2640 acgaagcagc tcatcgcccg cgagatcgag gtggagaaga tgcggcgggc ggaggcttct 2700 gcccgggtag agaacagccc ccaggtggat gggagccccc cagggctcga gggtctgctg 2760 gggggcattg gggagaaagg ggtgcaccga cctgccccac gcaaccatga gcagcggctg 2820 gagcacatca tgaggcgagc ggcccgggag gaacagcctg agaaggactt ctttggacgt 2880 gtggtcgtca ggagcacagc agtcccgagt gcaggggaca cggccccgga gcaggactca 2940 gtggagcggc gcatgggcac agcggtgggc aggagcgagg tctggttccg cttcaacgag 3000 ggtgtctcca acgccgtgcg gcgcagcctg tacatcaggg acttgctcta gttctctgag 3060 ccgcggacat gccctcgcat tgcttcccgc agagtgcaga gacaggaagc tggagatgtc 3120 tttataaagt cacaccttta cagactgtaa aaaaaaaaaa aaaaaa 3166 <210> 220 <211> 4494 <212> DNA <213> Homo sapiens <400> 220 gcggcggcgg cgcgggaggt tcggagcggg agctcgggct cgcggacggt atggaggact 60 acgagcagga gctgtgcggc gtcgaggatg atttccacaa ccagttcgcg gccgagctgg 120 aggtgctggc agagctggaa ggggcgtcga ctccgtcgcc ctccggggtc cccctgttca 180 ccgcgggccg acccccgcgg acgttcgagg aggcccttgc cagaggggac gcggcctcca 240 gtcccgcccc agccgcatct gtgggcagca gccagggcgg cgccaggaag aggcaggtgg 300 acgccgacct gcagccggcc gggtccctgc cccacgcccc caggatcaaa cggcctaggc 360 tgcaggtggt caagaggctg aacttcaggt cggaggagat ggaggagccg ccccctcccg 420 actcctcgcc gacggacatc accccgccgc cgagccctga ggacctcgca gagctttggg 480 gccacggagt ctcagaagct gctgccgacg tgggtctcac acgggcctca ccagctgccc 540 gcaatcccgt cctgaggcgg ccccccatct tggaggacta cgtccacgtg acatccacgg 600 agggcgtccg ggcttatctg gtgctgcgtg ctgaccccat ggccccgggg gtgcagctga 660 cccatctgga tggcttcatt cctttggcac ccctgtccag tctcccaccc ctcactggcc 720 agcttactgg ggttgtccca cccgggtccc tgagcactga tgggggctga cgtgaatcct 780 gtgacctagg aggggcccag aggcaattgt cctcccttcc ccacagggct ctctcctcca 840 cgtcccatgg cgaggcggtg gccagctgga cctgctgggt gtgtccttag cctccctgaa 900 gaagcaggtc gacggcgagc ggcgggagcg gctgcttcag gaggcccaga agctttcaga 960 caccctgcac agtctcaggt cgggggagga ggaggcagcc cagcccttgg gggcccctga 1020 ggaggagccg actgacggtc aagacgcctc cagtcactgc ctctgggtgg atgagtttgc 1080 accccgccac tacacggagc tgctcagtga tgacgtgagg tcttgttctc actcaagtgt 1140 ggctggcttc ctctgttccc aagatggaag aacctgggcc cagtgatttt tgcacagcca 1200 atccactggg cctcggagac ggagtgggct ctggtttgcc cttttgagtt gtaggtggtg 1260 aactgagcac agggctgtgt gctactggtc ccctgtgacc tgtgaggcag gctaggggtc 1320 cagggtgtca cctgatccaa gtctctgttc cctttcctac cttcacagca gctgacactg 1380 gagtgcccct ggggagggca ggggcctccc agatgggttg tggccagagc cgtgggggtg 1440 gagcccctgg tgtgagcctt gcggtcactc gctggcagga agacgggggt ggccattcat 1500 cctgtggctt ggcatcccat ggggcatggg gctcatggtg gcaggtggac tgtccgtgcc 1560 tggaggcggt gccctcaggc tgtgcttccc ttcccgtcct tcccgcagtt caccaaccgc 1620 tgcctgctca agtggctgaa gttgtgggac ctggtggtgt ttggccacga gaggccttcc 1680 cggaagccca ggcccagtgt tgagccggcc cgggtcagca aggaggccac agccccaggc 1740 aagtggaaga gccacgaaca ggtgctggag gagatgctgg aggctgggct ggacccgagc 1800 cagcgaccga agcagaaggt gagccccgct ggctgtgccg ccgggaacaa gcctgaggct 1860 ttgcactcgg cgccggcacc cttgcagcct gttgactttc tccaggagcc gtgggtgtgg 1920 tgacgtgtgg gtcttggcgt gaagcgccat tagcgtgagt tagaactgga gcgttgcagt 1980 aacaactcgg gggaagtcgt tgtccctgaa gggctctgcg gctggccagg atgatctggg 2040 tggacggtgg gtggtttctg ggggccagtc acactggtat cagctgtgtt ttgtctgcac 2100 gaactttgct ttgtgtaggt ttttttttcc gttgccatct tggtgtgtga aagtgctcaa 2160 ttttgttctt atttgatggc tggagtgggg tggagggagc gcccagcctg tgggacacat 2220 gtggcagtcc ctggctgcta ggccgggagc gtcctgtagg tgcggtgcac actacgcctt 2280 catctacctg ggctgcaggt ggcactgctc tgtgggcccc cggggctggg gaagaccacc 2340 ctggcacacg tgattgcgcg tcacgcgggg tactctgtgg tggagatgaa cgccaggtga 2400 gtgatgtgag gtccgtctct ggctcgcctt ctgtcctgac gtgtttgagt tctggtggcg 2460 gacctgaaac cgggtgtgga tgttcccgtc ttgagggtgg tgggggcctg ggtgtgtggg 2520 ccgggaaaac gtgtccttcc tcggggttca cgggatcggc agcagccgcg tcatgtgacg 2580 gtctccacgc aaatgcggca gccccggcct tgggaggctg ccctgccagg gacgcccact 2640 gccctgacga cccctgacct ccccattgca gtgacgaccg tagcccggag gtcttccgca 2700 cacgcatcga ggcggccacc cagatggagt cggtgctggg tgctggcggg aagcccaact 2760 gcctggtcat cgatgagatc gacggggccc ccgtggccgc catcaacgtc ctcctgagca 2820 tcctgaaccg caaggggcca caggaggtgg ggccacaggg cccggctgtg ccttcgggag 2880 gcggccgacg gcgccgggca gagggggggc tcctcatgag gcccattatc tgcatttgca 2940 atgaccagtt cgcaccgtcc ctgcggcagc tgaagcagca ggccttcctg ctccacttcc 3000 cgccgactct gccctcgagg ctggtgcagc ggctccagga ggtctccctg cggcagggca 3060 tgagggccga cccaggggtg ctggccgccc tctgtgagaa aactgacaat gacatccggg 3120 cctgcatcaa caccctgcag ttcctgtaca gccggggcca gcgggagctg agcgtgcggg 3180 acgtgcaggc cacacgcgtg ggcctcaagg accagcgcag agggctcttc tcggtgtggc 3240 aggaggtctt ccagctgcct cgagcccaga ggcgccgtgt gggccaggac cccgccctgc 3300 ctgctgacac actcctgctg ggtgacgggg acgcgggctc cctcacctcc gcctcacagc 3360 gattctaccg tgtcctgcat gccgctgcct ctgcgggcga gcacgagaag gtggtccagg 3420 gcttgtttga caacttcctg cgtctgcggc tgcgagactc cagcctgggt gctgtgtgtg 3480 tggccctcga ctggctggcc ttcgatgacc tgctggcggg ggctgctcat cacagccaga 3540 gcttccagct gctgcgctac ccacccttcc tgcccgtggc cttccatgtg ctgtttgctt 3600 ccagccacac acccaggatc accttcccca gcagccagca ggaggcccag aaccggatga 3660 gccagatgag gaacctgatc cagacgctgg tgtccggcat cgcgccagcc acgcgcagcc 3720 gggccacgcc ccaggccctg ctcctcgatg ccctctgcct gctcctggac attcttgcac 3780 ccaagctccg ccccgtgagc acacagctgt acagcacccg tgaaaagcaa cagctggcca 3840 gcctggtggg cacgatgctc gcttacagcc tgacctaccg ccaggagcgc acgcccgatg 3900 gccagtacat ctacaggctg gagccgaacg tggaggaact ctgccgcttc cctgagctgc 3960 ctgcccgcaa gcccctcacc taccagacga agcagctcat cgcccgcgag atcgaggtgg 4020 agaagatgcg gcgggcggag gcttctgccc gggtagagaa cagcccccag gtggatggga 4080 gccccccagg gctcgagggt ctgctggggg gcattgggga gaaaggggtg caccgacctg 4140 ccccacgcaa ccatgagcag cggctggagc acatcatgag gcgagcggcc cgggaggaac 4200 agcctgagaa ggacttcttt ggacgtgtgg tcgtcaggag cacagcagtc ccgagtgcag 4260 gggacacggc cccggagcag gactcagtgg agcggcgcat gggcacagcg gtgggcagga 4320 gcgaggtctg gttccgcttc aacgagggtg tctccaacgc cgtgcggcgc agcctgtaca 4380 tcagggactt gctctagttc tctgagccgc ggacatgccc tcgcattgct tcccgcagag 4440 tgcagagaca ggaagctgga gatgtcttta taaagtcaca cctttacaga ctgt 4494 <210> 221 <211> 4088 <212> DNA <213> Homo sapiens <400> 221 gcagtgcgcg acggcggcgg cggcgcggga ggttcggagc gggagctcgg gctcgcggac 60 ggtatggagg actacgagca ggagctgtgc ggcgtcgagg atgatttcca caaccagttc 120 gcggccgagc tggaggtgct ggcagagctg gaaggggcgt cgactccgtc gccctccggg 180 gtccccctgt tcaccgcggg ccgacccccg cggacgttcg aggaggccct tgccagaggg 240 gacgcggcct ccagtcccgc cccagccgca tctgtgggca gcagccaggg cggcgccagg 300 aagaggcagg cggcccccca tcttggagga ctacgtccac gtgacatcca cggagggcgt 360 ccgggcttat ctggtgctgc gtgctgaccc catggccccg ggggtgcagg gctctctcct 420 ccacgtccca tggcgaggcg gtggccagct ggacctgctg ggtgtgtcct tagcctccct 480 gaagaagcag gtcgacggcg agcggcggga gcggctgctt caggaggccc agaagctttc 540 agacaccctg cacagtctca ggtcggggga ggaggaggca gcccagccct tgggggcccc 600 tgaggaggag ccgactgacg gtcaagacgc ctccagtcac tgcctctggg tggatgagtt 660 tgcaccccgc cactacacgg agctgctcag tgatgacgtg aggtcttgtt ctcactcaag 720 tgtggctggc ttcctctgtt cccaagatgg aagaacctgg gcccagtgat ttttgcacag 780 ccaatccact gggcctcgga gacggagtgg gctctggttt gcccttttga gttgtaggtg 840 gtgaactgag cacagggctg tgtgctactg gtcccctgtg acctgtgagg caggctaggg 900 gtccaggggg tcacctgatc caagtctctg ttccctttcc taccttcaca gcagctgaca 960 ctggagtgcc cctggggagg gcaggggcct cccagatggg ttgtggccag agccgtgggg 1020 gtggagcccc tggtgtgagc cttgcggtca ctcgctggca ggaagacggg ggtggccatt 1080 catcctgtgg cttggcatcc catggggcat ggggctcatg gtggcaggtg gactgtccgt 1140 gcctggaggc ggtgccctca ggctgtgctt cccttcccgt ccttcccgca gttcaccaac 1200 cgctgcctgc tcaagtggct gaagttgtgg gacctggtgg tgtttggcca cgagaggcct 1260 tcccggaagc ccaggcccag tgttgagccg gcccgggtca gcaaggaggc cacagcccca 1320 ggcaagtgga agagccacga acaggtgctg gaggagatgc tggaggctgg gctggacccg 1380 agccagcgac cgaagcagaa ggtgagcccc gctggctgtg ccgccgggaa caagcctgag 1440 gctttgcact cggcgccggc acccttgcag cctgttgact ttctccagga gccgtgggtg 1500 tggtgacgtg tgggtcttgg cgtgaagcgc cattagcgtg agttagaact ggagcgttgc 1560 agtaacaact cgggggaagt cgttgtccct gaagggctct gcggctggcc aggatgatct 1620 gggtggacgg tgggtggttt ctgggggcca gtcacactgg tatcagctgt gttttgtctg 1680 cacgaacttt gctttgtgta ggtttttttt tccgttgcca tcttggtgtg tgaaagtgct 1740 caattttgtt cttatttgat ggctggagtg gggtggaggg agcgcccagc ctgtgggaca 1800 catgtggcag tccctggctg ctaggccggg agcgtcctgt aggtgcggtg cacactacgc 1860 cttcatctac ctgggctgca ggtggcactg ctctgtgggc ccccggggct ggggaagacc 1920 accctggcac acgtgattgc gcgtcacgcg gggtactctg tggtggagat gaacgccagg 1980 tgagtgatgt gaggtccgtc tctggctcgc cttctgtcct gacgtgtttg agttctggtg 2040 gcggacctga aaccgggtgt ggatgttccc gtcttgaggg tggtgggggc ctgggtgtgt 2100 gggccgggaa aacgtgtcct tcctcggggt tcacgggatc ggcagcagcc gcgtcatgtg 2160 acggtctcca cgcaaatgcg gcagccccgg ccttgggagg ctgccctgcc agggacgccc 2220 actgccctga cgacccctga cctccccatt gcagtgacga ccgtagcccg gaggtcttcc 2280 gcacacgcat cgaggcggcc acccagatgg agtcggtgct gggtgctggc gggaagccca 2340 actgcctgat catcgatgag atcgacgggg cccccgtggt gggctccttg atgcctgggc 2400 cgccatcaac gtcctcctga gcatcctgaa ccgcaagggg ccacaggagg tggggccaca 2460 gggcccggct gtgccttcgg gaggcggccg acggcgccgg gcagaggggg ggctcctcat 2520 gaggcccatt atctgcattt gcaatgacca gttcgcaccg tccctgcggc agctgaagca 2580 gcaggccttc ctgctccact tcccgccgac tctgccctcg aggctggtgc agcggctcca 2640 ggaggtctcc ctgcggcagg gcatgagggc cgacccaggg gtgctggccg ccctctgtga 2700 gaaaactgac aatgacatcc gggcctgcat caacaccctg cagttcctgt acagccgggg 2760 ccagcgggag ctgagcgtgc gggacgtgca ggccacacgc gtgggcctca aggaccagcg 2820 cagagggctc ttctcggtgt ggcaggaggt cttccagctg cctcgagccc agaggcgccg 2880 tgtgggccag gaccccgccc tgcctgctga cacactcctg ctgggtgacg gggacgcggg 2940 ctccctcacc tccgcctcac agcgattcta ccgtgtcctg catgccgctg cctctgcggg 3000 cgagcacgag aaggtggtcc agggcttgtt tgacaacttc ctgcgtctgc ggctgcgaga 3060 ctccagcctg ggtgctgtgt gtgtggccct cgactggctg gccttcgatg acctgctggc 3120 gggggctgct catcacagcc agagcttcca gctgctgcgc tacccaccct tcctgcccgt 3180 ggccttccat gtgctgtttg cttccagcca cacacccagg atcaccttcc ccagcagcca 3240 gcaggaggcc cagaaccgga tgagccagat gaggaacctg atccagacgc tggtgtccgg 3300 catcgcgcca gccacgcgca gccgggccac gccccaggcc ctgctcctcg atgccctctg 3360 cctgctcctg gacattcttg cacccaagct ccgccccgtg agcacacagc tgtacagcac 3420 ccgtgaaaag caacagctgg ccagcctggt gggcacgatg ctcgcttaca gcctgaccta 3480 ccgccaggag cgcacgcccg atggccagta catctacagg ctggagccga acgtggagga 3540 actctgccgc ttccctgagc tgcctgcccg caagcccctc acctaccaga cgaagcagct 3600 catcgcccgc gagatcgagg tggagaagat gcggcgggcg gaggcttctg cccgggtaga 3660 gaacagcccc caggtggatg ggagcccccc agggctcgag ggtctgctgg ggggcattgg 3720 ggagaaaggg gtgcaccgac ctgccccacg caaccatgag cagcggctgg agcacatcat 3780 gaggcgagcg gcccgggagg aacagcctga gaaggacttc tttggacgtg tggtcgtcag 3840 gagcacagca gtcccgagtg caggggacac ggccccggag caggactcag tggagcggcg 3900 catgggcaca gcggtgggca ggagcgaggt ctggttccgc ttcaacgagg gtgtctccaa 3960 cgccgtgcgg cgcagcctgt acatcaggga cttgctctag ttctctgagc cgcggacatg 4020 ccctcgcatt gcttcccgca gagtgcagag acaggaagct ggagatgtct ttataaagtc 4080 acaccttt 4088 <210> 222 <211> 3613 <212> DNA <213> Homo sapiens <400> 222 cacctcgcaa gggctccccc ctttccccac cccctccccc gacccttttc ccctccccgg 60 gccacccagc ccgcccaact cccagcggag agcaaggttt tcttctgttt tcatagccag 120 ccagaacaat gttctacgca cattttgttc tcagtaaaag agggcctctg gccaaaattt 180 ggctagcggc ccattgggat aagaagctaa ccaaagccca tgtgttcgag tgtaatttag 240 agagcagcgt ggagagtatc atctcaccaa aggtgaaaat ggcattacgg acatcaggac 300 atctcttact gggagtagtt cgaatctatc acaggaaagc caaatacctt cttgcagact 360 gtaatgaagc attcattaag ataaagatgg cttttcggcc aggtgtggtt gacctgcctg 420 aggaaaatcg ggaagcagct tataatgcca ttactttacc tgaagaattt catgactttg 480 atcagccact gcctgactta gatgacatcg atgtggccca gcagttcagc ttgaatcaga 540 gtagagtgga agagataacc atgagagaag aagttgggaa catcagtatt ttacaagaaa 600 atgattttgg tgattttgga atggatgatc gtgagataat gagagaaggc agtgcttttg 660 aggatgacga catgttagta agcactacta cttctaacct cctattagag tctgaacaga 720 gcaccagcaa tctgaatgag aaaattaacc atttagaata tgaagatcaa tataaggatg 780 ataattttgg agaaggaaat gatggtggaa tattagatga caaacttatt agtaataatg 840 atggcggtat ctttgatgat ccccctgccc tctctgaggc aggggtgatg ttgccagagc 900 agcctgcaca tgacgatatg gatgaggatg ataatgtatc aatgggtggg cctgatagtc 960 ctgattcagt ggatcccgtt gaaccaatgc caaccatgac tgatcaaaca acacttgttc 1020 caaatgagga agaagcattt gcattggagc ctattgatat aactgttaaa gaaacaaaag 1080 ccaagaggaa gaggaagcta attgttgaca gtgtcaaaga gttggatagc aagacaatta 1140 gagcccaact tagtgattat tcagatattg ttactacttt ggatctggca ccgcccacca 1200 agaaattgat gatgtggaaa gagacaggag gagtagaaaa actgttttct ttacctgctc 1260 agcctttgtg gaataacaga ctactgaagc tctttacacg ctgtcttaca ccgcttgtac 1320 cagaagacct tagaaaaagg aggaaaggag gagaggcaga taatttggat gaattcctca 1380 aagaatttga aaatccagag gttcctagag aggaccagca acagcagcat cagcagcgtg 1440 atgttatcga tgagcccatt attgaagagc caagccgcct ccaggagtca gtgatggagg 1500 ccagcagaac aaacatagat gagtcagcta tgcctccacc accacctcag ggagttaagc 1560 gaaaagctgg acaaattgac ccagagcctg tgatgcctcc tcagcaggta gagcagatgg 1620 aaataccacc tgtagagctt cccccagaag aacctccaaa tatctgtcag ctaataccag 1680 agttagaact tctgccagaa aaagagaagg agaaagagaa ggaaaaagaa gatgatgaag 1740 aggaagagga tgaagatgca tcagggggcg atcaagatca ggaagaaaga agatggaaca 1800 aaaggactca gcagatgctt catggtcttc agcgtgctct tgctaaaact ggagctgaat 1860 ctatcagttt gcttgagtta tgtcgaaata cgaacagaaa acaagctgcc gcaaagttct 1920 acagcttctt ggttcttaaa aagcagcaag ctattgagct gacacaggaa gaaccgtaca 1980 gtgacatcat cgcaacacct ggaccaaggt tccatattat ataaggagct agaagcatta 2040 tagctagtgt ttgattcact agtgcttaca aattgccccc atgtgtaggg gacacagaac 2100 cctttgagaa aacttagatt tttgtctgta caaagtcttt gcctttttcc ttcttcattt 2160 ttttccagta cattaaattt gtcaatttca tctttgaggg aaactgatta gatgggttgt 2220 gtttgtgttc tgatggagaa aacagcaccc caaggactca gaagatgatt ttaacagttc 2280 agaacagatg tgtgcaatat tggtgcatgt aataatgttg agtggcagtc aaaagtcatg 2340 atttttatct tagttcttca ttactgcatt gaaaaggaaa acctgtctga gaaaatgcct 2400 gacagtttaa tttaaaacta tggtgtaagt ctttgacaag aaaaaaaaac aaacaaacac 2460 ttctttccat cagtaacact ggcaatcttc ctgttaacca ctctccttag ggatggtatc 2520 tgaaacaaca atggtcaccc tcttgagatt cgttttaagt gtaattccat aatgagcaga 2580 ggtgtacgcg aaattgtgtt atgactgata gccttcagct acaaaaagat aggactgacc 2640 tggtttaaag tgttctattt tgtaaatcat tccatttgag tctttctgat gaacttggct 2700 atactgaaat ctgttatttt agtgaggctc caaaatgagc aaagctaggc ctgattagag 2760 tagagtgact attaaaaaac ataactttct aggagctata aatcaaagtt ttaaaaagat 2820 gtttggatat atttgagtat tccgatcatg aaaacagaaa ttgccctgcc tactacaagg 2880 acagactgat gggaaattat gcacctggtc aacttagctt ttaagcagac gatgctgtaa 2940 aaactaacgg cttctctgat atttattgta agttttagta ctgatctcct tttccagtgc 3000 tgcacactcc tggtttggaa ctttaatagc gttgcaacga aatcctatat ccagtttcct 3060 gtaatttaat tgaagaaaaa tacatccaaa taaagacttt attattaaca gaccagatag 3120 catcagaaat catgtgactg ttatgattat cagaatgtct taacttttta gggcaaagtt 3180 aacactgaaa gttctagctt aagtgttgaa acttttgtgg gaaaaaaaaa tcacttttga 3240 aactcagact tcagtgtata cccaataatt taaaattatg tgaaatgttt taaatttgtg 3300 aactcgtaat tactgtttta atgattcagt ttcttcagag tggtaattgt ataaaattgc 3360 tattgcagct ttacattcaa tatgatgtgc ctgtaaacca aggagttttc cccgtttgta 3420 aaaagacatt gtagataatt gaatgtttga ttttagaaag gtcattagtt tcttgttaca 3480 cattttgtta gtctggtttt tgttgcttat cgggtttaat attgttcttg aaaatagttg 3540 atgctatgtt atgtataact tttctaataa aagttgtgtt ataagctgta aaaaaaaaaa 3600 aaaaaaaaaa aaa 3613 <210> 223 <211> 3647 <212> DNA <213> Homo sapiens <400> 223 agtgaatcgg aaaggaggcg ccggctgtgg cggcggcggg agctgctcgg aagctacacc 60 tcgcaagggc tccccccttt ccccaccccc tcccccgacc cttttcccct ccccgggcca 120 cccagcccgc ccaactccca gcggagagca aggttttctt ctgttttcat agccagccag 180 aacaatgttc tacgcacatt ttgttctcag taaaagaggg cctctggcca aaatttggct 240 agcggcccat tgggataaga agctaaccaa agcccatgtg ttcgagtgta atttagagag 300 cagcgtggag agtatcatct caccaaaggt gaaaatggca ttacggacat caggacatct 360 cttactggga gtagttcgaa tctatcacag gaaagccaaa taccttcttg cagactgtaa 420 tgaagcattc attaagataa agatggcttt tcggccaggt gtggttgacc tgcctgagga 480 aaatcgggaa gcagcttata atgccattac tttacctgaa gaatttcatg actttgatca 540 gccactgcct gacttagatg acatcgatgt ggcccagcag ttcagcttga atcagagtag 600 agtggaagag ataaccatga gagaagaagt tgggaacatc agtattttac aagaaaatga 660 ttttggtgat tttggaatgg atgatcgtga gataatgaga gaaggcagtg cttttgagga 720 tgacgacatg ttagtaagca ctactacttc taacctccta ttagagtctg aacagagcac 780 cagcaatctg aatgagaaaa ttaaccattt agaatatgaa gatcaatata aggatgataa 840 ttttggagaa ggaaatgatg gtggaatatt agatgacaaa cttattagta ataatgatgg 900 cggtatcttt gatgatcccc ctgccctctc tgaggcaggg gtgatgttgc cagagcagcc 960 tgcacatgac gatatggatg aggatgataa tgtatcaatg ggtgggcctg atagtcctga 1020 ttcagtggat cccgttgaac caatgccaac catgactgat caaacaacac ttgttccaaa 1080 tgaggaagaa gcatttgcat tggagcctat tgatataact gttaaagaaa caaaagccaa 1140 gaggaagagg aagctaattg ttgacagtgt caaagagttg gatagcaaga caattagagc 1200 ccaacttagt gattattcag atattgttac tactttggat ctggcaccgc ccaccaagaa 1260 attgatgatg tggaaagaga caggaggagt agaaaaactg ttttctttac ctgctcagcc 1320 tttgtggaat aacagactac tgaagctctt tacacgctgt cttacaccgc ttgtaccaga 1380 agaccttaga aaaaggagga aaggaggaga ggcagataat ttggatgaat tcctcaaaga 1440 atttgaaaat ccagaggttc ctagagagga ccagcaacag cagcatcagc agcgtgatgt 1500 tatcgatgag cccattattg aagagccaag ccgcctccag gagtcagtga tggaggccag 1560 cagaacaaac atagatgagt cagctatgcc tccaccacca cctcagggag ttaagcgaaa 1620 agctggacaa attgacccag agcctgtgat gcctcctcag caggtagagc agatggaaat 1680 accacctgta gagcttcccc cagaagaacc tccaaatatc tgtcagctaa taccagagtt 1740 agaacttctg ccagaaaaag agaaggagaa agagaaggaa aaagaagatg atgaagagga 1800 agaggatgaa gatgcatcag ggggcgatca agatcaggaa gaaagaagat ggaacaaaag 1860 gactcagcag atgcttcatg gtcttcagcg tgctcttgct aaaactggag ctgaatctat 1920 cagtttgctt gagttatgtc gaaatacgaa cagaaaacaa gctgccgcaa agttctacag 1980 cttcttggtt cttaaaaagc agcaagctat tgagctgaca caggaagaac cgtacagtga 2040 catcatcgca acacctggac caaggttcca tattatataa ggagctagaa gcattatagc 2100 tagtgtttga ttcactagtg cttacaaatt gcccccatgt gtaggggaca cagaaccctt 2160 tgagaaaact tagatttttg tctgtacaaa gtctttgcct ttttccttct tcattttttt 2220 ccagtacatt aaatttgtca atttcatctt tgagggaaac tgattagatg ggttgtgttt 2280 gtgttctgat ggagaaaaca gcaccccaag gactcagaag atgattttaa cagttcagaa 2340 cagatgtgtg caatattggt gcatgtaata atgttgagtg gcagtcaaaa gtcatgattt 2400 ttatcttagt tcttcattac tgcattgaaa aggaaaacct gtctgagaaa atgcctgaca 2460 gtttaattta aaactatggt gtaagtcttt gacaagaaaa aaaaacaaac aaacacttct 2520 ttccatcagt aacactggca atcttcctgt taaccactct ccttagggat ggtatctgaa 2580 acaacaatgg tcaccctctt gagattcgtt ttaagtgtaa ttccataatg agcagaggtg 2640 tacgcgaaat tgtgttatga ctgatagcct tcagctacaa aaagatagga ctgacctggt 2700 ttaaagtgtt ctattttgta aatcattcca tttgagtctt tctgatgaac ttggctatac 2760 tgaaatctgt tattttagtg aggctccaaa atgagcaaag ctaggcctga ttagagtaga 2820 gtgactatta aaaaacataa ctttctagga gctataaatc aaagttttaa aaagatgttt 2880 ggatatattt gagtattccg atcatgaaaa cagaaattgc cctgcctact acaaggacag 2940 actgatggga aattatgcac ctggtcaact tagcttttaa gcagacgatg ctgtaaaaac 3000 taacggcttc tctgatattt attgtaagtt ttagtactga tctccttttc cagtgctgca 3060 cactcctggt ttggaacttt aatagcgttg caacgaaatc ctatatccag tttcctgtaa 3120 tttaattgaa gaaaaataca tccaaataaa gactttatta ttaacagacc agatagcatc 3180 agaaatcatg tgactgttat gattatcaga atatgtctta actttttagg gcaaagttaa 3240 cactgaaagt tctagcttaa gtgttgaaac ttttgtggga aaaaaaaatc acttttgaaa 3300 ctcagacttc agtgtatacc caataattta aaattatgtg aaatgtttta aatttgtgaa 3360 ctcgtaatta ctgttttaat gattcagttt cttcagagtg gtaattgtat aaaattgcta 3420 ttgcagcttt atattcaata tgatgtgcct gtaaaccaag gagttttccc cgtttgtaaa 3480 aagacattgt agataattga atgtttgatt ttagaaaggt cattagtttc ttgttacaca 3540 ttttgttagt ctggtttttg ttgcttatcg ggtttaatat tgttcttgaa aatagttgat 3600 gctatgttat gtataacttt tctaataaaa gttgtgttat aagctgt 3647 <210> 224 <211> 3647 <212> DNA <213> Homo sapiens <400> 224 agtgaatcgg aaaggaggcg ccggctgtgg cggcggcggg agctgctcgg aagctacacc 60 tcgcaagggc tccccccttt ccccaccccc tcccccgacc cttttcccct ccccgggcca 120 cccagcccgc ccaactccca gcggagagca aggttttctt ctgttttcat agccagccag 180 aacaatgttc tacgcacatt ttgttctcag taaaagaggg cctctggcca aaatttggct 240 agcggcccat tgggataaga agctaaccaa agcccatgtg ttcgagtgta atttagagag 300 cagcgtggag agtatcatct caccaaaggt gaaaatggca ttacggacat caggacatct 360 cttactggga gtagttcgaa tctatcacag gaaagccaaa taccttcttg cagactgtaa 420 tgaagcattc attaagataa agatggcttt tcggccaggt gtggttgacc tgcctgagga 480 aaatcgggaa gcagcttata atgccattac tttacctgaa gaatttcatg actttgatca 540 gccactgcct gacttagatg acatcgatgt ggcccagcag ttcagcttga atcagagtag 600 agtggaagag ataaccatga gagaagaagt tgggaacatc agtattttac aagaaaatga 660 ttttggtgat tttggaatgg atgatcgtga gataatgaga gaaggcagtg cttttgagga 720 tgacgacatg ttagtaagca ctactacttc taacctccta ttagagtctg aacagagcac 780 cagcaatctg aatgagaaaa ttaaccattt agaatatgaa gatcaatata aggatgataa 840 ttttggagaa ggaaatgatg gtggaatatt agatgacaaa cttattagta ataatgatgg 900 cggtatcttt gatgatcccc ctgccctctc tgaggcaggg gtgatgttgc cagagcagcc 960 tgcacatgac gatatggatg aggatgataa tgtatcaatg ggtgggcctg atagtcctga 1020 ttcagtggat cccgttgaac caatgccaac catgactgat caaacaacac ttgttccaaa 1080 tgaggaagaa gcatttgcat tggagcctat tgatataact gttaaagaaa caaaagccaa 1140 gaggaagagg aagctaattg ttgacagtgt caaagagttg gatagcaaga caattagagc 1200 ccaacttagt gattattcag atattgttac tactttggat ctggcaccgc ccaccaagaa 1260 attgatgatg tggaaagaga caggaggagt agaaaaactg ttttctttac ctgctcagcc 1320 tttgtggaat aacagactac tgaagctctt tacacgctgt cttacaccgc ttgtaccaga 1380 agaccttaga aaaaggagga aaggaggaga ggcagataat ttggatgaat tcctcaaaga 1440 atttgaaaat ccagaggttc ctagagagga ccagcaacag cagcatcagc agcgtgatgt 1500 tatcgatgag cccattattg aagagccaag ccgcctccag gagtcagtga tggaggccag 1560 cagaacaaac atagatgagt cagctatgcc tccaccacca cctcagggag ttaagcgaaa 1620 agctggacaa attgacccag agcctgtgat gcctcctcag caggtagagc agatggaaat 1680 accacctgta gagcttcccc cagaagaacc tccaaatatc tgtcagctaa taccagagtt 1740 agaacttctg ccagaaaaag agaaggagaa agagaaggaa aaagaagatg atgaagagga 1800 agaggatgaa gatgcatcag ggggcgatca agatcaggaa gaaagaagat ggaacaaaag 1860 gactcagcag atgcttcatg gtcttcagcg tgctcttgct aaaactggag ctgaatctat 1920 cagtttgctt gagttatgtc gaaatacgaa cagaaaacaa gctgccgcaa agttctacag 1980 cttcttggtt cttaaaaagc agcaagctat tgagctgaca caggaagaac cgtacagtga 2040 catcatcgca acacctggac caaggttcca tattatataa ggagctagaa gcattatagc 2100 tagtgtttga ttcactagtg cttacaaatt gcccccatgt gtaggggaca cagaaccctt 2160 tgagaaaact tagatttttg tctgtacaaa gtctttgcct ttttccttct tcattttttt 2220 ccagtacatt aaatttgtca atttcatctt tgagggaaac tgattagatg ggttgtgttt 2280 gtgttctgat ggagaaaaca gcaccccaag gactcagaag atgattttaa cagttcagaa 2340 cagatgtgtg caatattggt gcatgtaata atgttgagtg gcagtcaaaa gtcatgattt 2400 ttatcttagt tcttcattac tgcattgaaa aggaaaacct gtctgagaaa atgcctgaca 2460 gtttaattta aaactatggt gtaagtcttt gacaagaaaa aaaaacaaac aaacacttct 2520 ttccatcagt aacactggca atcttcctgt taaccactct ccttagggat ggtatctgaa 2580 acaacaatgg tcaccctctt gagattcgtt ttaagtgtaa ttccataatg agcagaggtg 2640 tacgcgaaat tgtgttatga ctgatagcct tcagctacaa aaagatagga ctgacctggt 2700 ttaaagtgtt ctattttgta aatcattcca tttgagtctt tctgatgaac ttggctatac 2760 tgaaatctgt tattttagtg aggctccaaa atgagcaaag ctaggcctga ttagagtaga 2820 gtgactatta aaaaacataa ctttctagga gctataaatc aaagttttaa aaagatgttt 2880 ggatatattt gagtattccg atcatgaaaa cagaaattgc cctgcctact acaaggacag 2940 actgatggga aattatgcac ctggtcaact tagcttttaa gcagacgatg ctgtaaaaac 3000 taacggcttc tctgatattt attgtaagtt ttagtactga tctccttttc cagtgctgca 3060 cactcctggt ttggaacttt aatagcgttg caacgaaatc ctatatccag tttcctgtaa 3120 tttaattgaa gaaaaataca tccaaataaa gactttatta ttaacagacc agatagcatc 3180 agaaatcatg tgactgttat gattatcaga atatgtctta actttttagg gcaaagttaa 3240 cactgaaagt tctagcttaa gtgttgaaac ttttgtggga aaaaaaaatc acttttgaaa 3300 ctcagacttc agtgtatacc caataattta aaattatgtg aaatgtttta aatttgtgaa 3360 ctcgtaatta ctgttttaat gattcagttt cttcagagtg gtaattgtat aaaattgcta 3420 ttgcagcttt atattcaata tgatgtgcct gtaaaccaag gagttttccc cgtttgtaaa 3480 aagacattgt agataattga atgtttgatt ttagaaaggt cattagtttc ttgttacaca 3540 ttttgttagt ctggtttttg ttgcttatcg ggtttaatat tgttcttgaa aatagttgat 3600 gctatgttat gtataacttt tctaataaaa gttgtgttat aagctgt 3647 <210> 225 <211> 1893 <212> DNA <213> Homo sapiens <400> 225 atgttctacg cacattttgt tctcagtaaa agagggcctc tggccaaaat ttggctagcg 60 gcccattggg ataagaagct aaccaaagcc catgtgttcg agtgtaattt agagagcagc 120 gtggagagta tcatctcacc aaaggtgaaa atggcattac ggacatcagg acatctctta 180 ctgggagtag ttcgaatcta tcacaggaaa gccaaatacc ttcttgcaga ctgtaatgaa 240 gcattcatta agataaagat ggcttttcgg ccaggtgtgg ttgacctgcc tgaggaaaat 300 cgggaagcag cttataatgc cattacttta cctgaagaat ttcatgactt tgatcagcca 360 ctgcctgact tagatgacat cgatgtggcc cagcagttca gcttgattca gagtagagtg 420 gaagagataa ccatgagaga agaagttggg aacatcagta ttttacaaga aaatgatttt 480 ggtgattttg gaatggatga tcgtgagata atgagagaag gcagtgcttt tgaggatgac 540 gacatgttag taagcactac tacttctaac ctcctattag agtctgaaca gagcaccagc 600 aatctgaatg agaaaattaa ccatttagaa tatgaagatc aatataagga tgataatttt 660 ggagaaggaa atgatggtgg aatattagat gacaaactta ttagtaataa tgatggcggt 720 atctttgatg atccccctgc cctctctgag gcaggggtga tgttgccaga gcagcctgca 780 catgacgata tggatgagga tgataatgta tcaatgggtg ggcctgatag tcctgattca 840 gtggatcccg ttgaaccaat gccaaccatg actgatcaaa caacacttgt tccaaatgag 900 gaagaagcat ttgcattgga gcctattgat ataactgtta aagaaacaaa agccaagagg 960 aagaggaagc taattgttga cagtgtcaaa gagttggata gcaagacaat tagagcccaa 1020 cttagtgatt attcagatat tgttactact ttggatctgg caccgcccac caagaaattg 1080 atgatgtgga aagagacagg aggagtagaa aaactgtttt ctttacctgc tcagcctttg 1140 tggaataaca gactactgaa gctctttaca cgctgtctta caccgcttgt accagaagac 1200 cttagaaaaa ggaggaaagg aggagaggca gataatttgg atgaattcct caaagaattt 1260 gaaaatccag aggttcctag agaggaccag caacagcagc atcagcagcg tgatgttatc 1320 gatgagccca ttattgaaga gccaagccgc ctccaggagt cagtgatgga ggccagcaga 1380 acaaacatag atgagtcagc tatgcctcca ccaccacctc agggagttaa gcgaaaagct 1440 ggacaaattg acccagagcc tgtgatgcct cctcagcagg tagagcagat ggaaatacca 1500 cctgtagagc ttcccccaga agaacctcca aatatctgtc agctaatacc agagttagaa 1560 cttctgccag aaaaagagaa ggagaaagag aaggaaaaag aagatgatga agaggaagag 1620 gatgaagatg catcaggggg cgatcaagat caggaagaaa gaagatggaa caaaaggact 1680 cagcagatgc ttcatggtct tcagcgtgct cttgctaaaa ctggagctga atctatcagt 1740 ttgcttgagt tatgtcgaaa tacgaacaga aaacaagctg ccgcaaagtt ctacagcttc 1800 ttggttctta aaaagcagca agctattgag ctgacacagg aagaaccgta cagtgacatc 1860 atcgcaacac ctggaccaag gttccatatt ata 1893 <210> 226 <211> 1593 <212> DNA <213> Homo sapiens <400> 226 gaaaatgatt ttggtaattt tggaatggat gatcgtgaga taatgagaga aggcagtgct 60 tttgaggatg acgacatgtt agtaagcact actacttcta acctcctatt agagtctgaa 120 cagagcacca gcaatctgaa tgagaaaatt aaccatttag aatatgaaga tcaatataag 180 gatgataatt ttggagaagg aaatgatggt ggaatattag atgacaaact tattagtaat 240 aatgatggcg gtatctttga tgatccccct gccctctctg aggcaggggt gatgttgcca 300 gagcagcctg cacatgacga tatggatgag gatgataatg tatcaatggg tgggcctgat 360 agtcctgatt cagtggatcc cgttgaacca atgccaacca tgactgatca aacaacactt 420 gttccaaatg aggaagaagc atttgcattg gagcctattg atataactgt taaagaaaca 480 aaagccaaga ggaagaggaa gctaattgtt gacagtgtca aagagttgga tagcaagaca 540 attagagccc aacttagtga ttattcagat attgttacta ctttggatct ggcaccgccc 600 accaagaaat tgatgatgtg gaaagagaca ggaggagtag aaaaactgtt ttctttacct 660 gctcagcctt tgtggaataa cagactactg aagctcttta cacgctgtct tacaccgctt 720 gtaccagaag accttagaaa aaggaggaaa ggaggagagg cagataattt ggatgaattc 780 ctcaaagaat ttgaaaatcc agaggttcct agagaggacc agcaacagca gcatcagcag 840 cgtgatgtta tcgatgagcc cattattgaa gagccaagcc gcctccagga gtcagtgatg 900 gaggccagca gaacaaacat agatgagtca gctatgcctc caccaccacc tcagggagtt 960 aagcgaaaag ctggacaaat tgacccagag cctgtgatgc ctcctcagca ggtagagcag 1020 atggaaatac cacctgtaga gcttccccca gaagaacctc caaatatctg tcagctaata 1080 ccagagttag aacttctgcc agaaaaagag aaggagaaag agaaggaaaa agaagatgat 1140 gaagaggaag aggatgaaga tgcatcaggg ggcgatcaag atcaggaaga aagaagatgg 1200 aacaaaagga ctcagcagat gcttcatggt cttcagcgtg ctcttgctaa aactggagct 1260 gaatctatca gtttgcttga gttatgtcga aatacgaaca gaaaacaagc tgccgcaaag 1320 ttctacagct tcttggttct taaaaagcag caagctattg agctgacaca ggaagaaccg 1380 tacagtgaca tcatcgcaac acctggacca aggttccata ttatataagg agctagaagc 1440 attatagcta gtgtttgatt cactagtgct tacaaattgc ccccatgtgt aggggacaca 1500 gaaccctttg agaaaactta gatttttgtc tgtacaaagt ctttgccttt ttccttcttc 1560 atttttttcc agtacattaa atttgtcaat ttc 1593 <210> 227 <211> 2209 <212> DNA <213> Homo sapiens <400> 227 cttcgcctcg ggcccgccct cggcccggac ccatgcagct tgggcccgca tcatcgcttg 60 ttcggttttc ttctgttttc atagccagcc agaacaatgt tctacgcaca ttttgttctc 120 agtaaaagag ggcctctggc caaaatttgg ctagcggccc attgggataa gaagctaacc 180 aaagcccatg tgttcgagtg taatttagag agcagcgtgg agagtatcat ctcaccaaag 240 gtgaaaatgg cattacggac atcaggacat ctcttactgg gagtagttcg aatctatcac 300 aggaaagcca aataccttct tgcagactgt aatgaagcat tcattaagat aaagatggct 360 tttcggccag gtgtggttga cctgcctgag gaaaatcagg aagaaagaag atggaacaaa 420 aggactcagc agatgcttca tggtcttcag cgcgctcttg ctaaaactgg agctgaatct 480 atcagtttgc ttgagttatg tcgaaatacg aacagaaaac aagctgccgc aaagttctac 540 agcttcttgg ttcttaaaaa gcagcaagct attgagctga cacaggaaga accgtacagt 600 gacatcatcg caacacctgg accaaggttc catattatat aaggagctag aagcattata 660 gctagtgttt gattcactag tgcttacaaa ttgcccccat gtgtagggga cacagaaccc 720 tttgagaaaa cttagatttt tgtctgtaca aagtctttgc ctttttcctt cttcattttt 780 ttccagtaca ttaaatttgt caatttcatc tttgagggaa actgattaga tgggttgtgt 840 ttgtgttctg atggagaaaa cagcacccca aggactcaga agatgatttt aacagttcag 900 aacagatgtg tgcaatattg gtgcatgtaa taatgttgag tggcagtcaa aagtcatgat 960 ttttatctta gttcttcatt actgcattga aaaggaaaac ctgtctgaga aaatgcctga 1020 cagtttaatt taaaactatg gtgtaagtct ttgacaagaa aaaaaaacaa acaaacactt 1080 ctttccatca gtaacactgg caatcttcct gttaaccact ctccttaggg atggtatctg 1140 aaacaacaat ggtcaccctc ttgagattcg ttttaagtgt aattccataa tgagcagagg 1200 tgtacgcgaa attgtgttat gactgatagc cttcagctac aaaaagatag gactgacctg 1260 gtttaaagtg ttctattttg taaatcattc catttgagtc tttctgatga acttggctat 1320 actgaaatct gttattttag tgaggctcca aaatgagcaa agctaggcct gattagagta 1380 gagtgactat taaaaaacat aactttctag gagctataaa tcaaagtttt aaaaagatgt 1440 ttggatatat ttgagtattc cgatcatgaa aacagaaatt gccctgccta ctacaaggac 1500 agactgatgg gaaattatgc acctggtcaa cttagctttt aagcagacga tgctgtaaaa 1560 actaacggct tctctgatat ttattgtaag ttttagtact gatctccttt tccagtgctg 1620 cacactcctg gtttggaact ttaatagcgt tgcaacgaaa tcctatatcc agtttcctgt 1680 aatttaattg aagaaaaata catccaaata aagactttat tattaacaga ccagatagca 1740 tcagaaatca tgtgactgtt atgattatca gaatatgtct taacttttta gggcaaagtt 1800 aacactgaaa gttctagctt aagtgttgaa acttttgtgg gaaaaaaaaa tcacttttga 1860 aactcagact tcagtgtata cccaataatt taaaattatg tgaaatgttt taaatttgtg 1920 aactcgtaat tactgtttta atgattcagt ttcttcagag tggtaattgt ataaaattgc 1980 tattgcagct ttatattcaa tatgatgtgc ctgtaaacca aggagttttc cccgtttgta 2040 aaaagacatt gtagataatt gaatgtttga ttttagaaag gtcattagtt tcttgttaca 2100 cattttgtta gtctggtttt tgttgcttat cgggtttaat attgttcttg aaaatagttg 2160 atgctatgtt atgtataact tttctaataa aagttgtgtt ataagctgt 2209 <210> 228 <211> 1882 <212> DNA <213> Homo sapiens <400> 228 ggatgaagat gcatcagggg gcgatcaaga tcaggaagaa agaagatgga acaaaaggac 60 tcagcagatg cttcatggtc ttcagcgtgc tcttgctaaa actggagctg aatctatcag 120 tttgcttgag ttatgtcgaa atacgaacag aaaacaagct gccgcaaagt tctacagctt 180 cttggttctt aaaaagcagc aagctattga gctgacacag gaagaaccgt acagtgacat 240 catcgcaaca cctggaccaa ggttccatat tatataagga gctagaagca ttatagctag 300 tgtttgattc actagtgctt acaaattgcc cccatgtgta ggggacacag aaccctttga 360 gaaaacttag atttttgtct gtacaaagtc tttgcctttt tccttcttca tttttttcca 420 gtacattaaa tttgtcaatt tcatctttga gggaaactga ttagatgggt tgtgtttgtg 480 ttctgatgga gaaaacagca ccccaaggac tcagaagatg attttaacag ttcagaacag 540 atgtgtgcaa tattggtgca tgtaataatg ttgagtggca gtcaaaagtc atgattttta 600 tcttagttct tcattactgc attgaaaagg aaaacctgtc tgagaaaatg cctgacagtt 660 taatttaaaa ctatggtgta agtctttgac aagaaaaaaa aacaaacaaa cacttctttc 720 catcagtaac actggcaatc ttcctgttaa ccactctcct tagggatggt atctgaaaca 780 acaatggtca ccctcttgag attcgtttta agtgtaattc cataatgagc agaggtgtac 840 gcgaaattgt gttatgactg atagccttca gctacaaaaa gataggactg acctggttta 900 aagtgttcta ttttgtaaat cattccattt gagtctttct gatgaacttg gctatactga 960 aatctgttat tttagtgagg ctccaaaatg agcaaagcta ggcctgatta gagtagagtg 1020 actattaaaa aacataactt tctaggagct ataaatcaaa gttttaaaaa gatgtttgga 1080 tatatttgag tattccgatc atgaaaacag aaattgccct gcctactaca aggacagact 1140 gatgggaaat tatgcacctg gtcaacttag cttttaagca gacgatgctg taaaaactaa 1200 cggcttctct gatatttatt gtaagtttta gtactgatct ccttttccag tgctgcacac 1260 tcctgtgttt ggaactttaa tagcgttgca acgaaatcct atatccagtt tcctgtaatt 1320 taattgaaga aaaatacatc caaataaaga ctttattatt aacagaccag atagcatcag 1380 aaatcatgtg actgttatga ttatcagaat atgtcttaac tttttagggc aaagttaaca 1440 ctgaaagttc tagcttaagt gttgaaactt ttgtgggaaa aaaaaatcac ttttgaaact 1500 cagacttcag tgtataccca ataatttaaa attatgtgaa atgttttaaa tttgtgaact 1560 cgtaattact gttttaatga ttcagtttct tcagagtggt aattgtataa aattgctatt 1620 gcagctttat attcaatatg atgtgcctgt aaaccaagga gttttccctg tttgtaaaaa 1680 gacattgtag ataattgaat gtttgatttt agaaaggtca ttagtttctt gttacacatt 1740 ttgttagtct ggtttttgtt gcttatcggg tttaatattg ttcttgaaaa tagttgatgc 1800 tatgttatgt ataacttttc taataaaagt tgtgttataa gctgtaaaaa aaaaaaaaaa 1860 aaaaaaaaaa aaaaaaaaaa aa 1882 <210> 229 <211> 2254 <212> DNA <213> Homo sapiens <400> 229 ttgagtaaat ctttatggag ctaaaatttt atctggcctt cttcattaaa gaaagcatta 60 tgtatgtctt agtgtactag tttaaaaaat aaatggttct ataatactgt tcaaaactgt 120 atgacctatg ttttctcttc atatgaccaa ttgcagatga gcccattatt gaagagccaa 180 gccgcctcca ggagtcagtg atggaggcca gcagaacaaa catagatgag tcagctatgc 240 ctccaccacc acctcaggga gttaagcgaa aagctggaca aattgaccca gagcctgtga 300 tgcctgtaag taagcaaatc tatccattaa gtcatttgaa ggtattcata cagtcagtag 360 caagtggtat ttagggaggc cttttaaagt atcttggttt tgacagaaaa tggtaaggaa 420 tgagtccaga ggaagaagag caacaggata tagacagtcc actcggagtg agagaatatg 480 ttctgggagt cggtgcagtc tttcctgact ctttttgaat agtattgctt tagagtgctc 540 cagagtgagc atccttgact ctgaagttgg ttctgattta ttatttggca aacattcctg 600 cacaccttca gtactaggca gttttaggtc atcttattaa gtaatcagaa taaacttcaa 660 atacctgaga aaatgtaaag cagtatctgt ctgcttcatt caaactttga ctaccattga 720 gttcagctag gataggaaag ctaagcaagt atgaaggagg aaatagtagg gtttggttta 780 gggctttcca atcttaagtc catagaataa atgaatttgt gcaaagggag gcttttagat 840 aaccttaggc ttcttgttca gcctccatca agaatactct gccaatttta agaactagtt 900 ttctgtgccc tctggtggta agagttgtca ataagagcat ttttctgtat gagctcagga 960 ataggaacac agtaatgagt aggtgacttt cataaccacc ctccttctgg taattcttta 1020 gtttctttta aagactttgg ttttaatgtt cttaactctt tctgtaaagc ctgagagaag 1080 atataggaag tggacccaga aaagcaatgt cctcactcct attatttgct gccgtgagac 1140 attcaagact ctcagagaga aagcttatga tttataagtt acaatataat aaccttacag 1200 aagctttagt agttaaaaag catttgactc ctaaaaagta agtatgaaaa tgaaacatgg 1260 tttaggataa gcagtcagtt tcttttgtaa gctacttcaa tgtagtttta taaaaaatca 1320 aaaaagatat atactgtaat aaatttttcc ttgtggggaa gtatagagat ataatctcag 1380 tatttctttt tgactagaaa acttcagcca ctgtgtattt tcatatttaa aataagctac 1440 tttaaaagca tatatcttaa attgtcttat ttgtattgct ttaagcctca gcaggtagag 1500 cagatggaaa taccacctgt agagcttccc ccagaagaac ctccaaatat ctgtcagcta 1560 ataccagagt tagaacttct gccagaaaaa gagaaggaga aagagaagga aaaagaagat 1620 gatgaagagg aagaggatga agatgcatca gggggcgatc aagatcagga agaaagaaga 1680 tggaacaaaa ggactcagca gatgcttcat ggtcttcagc gtgctcttgc taaaactgga 1740 gctgaatcta tcagtttgct tgagttatgt cgaaatacga acagaaaaca agctgccgca 1800 aagttctaca gcttcttggt tcttaaaaag cagcaagcta ttgagctgac acaggaagaa 1860 ccgtacagtg acatcatcgc aacacctgga ccaaggttcc atattatata aggagctaga 1920 agcattatag ctagtgtttg attcactagt gcttacaaat tgcccccatg tgtaggggac 1980 acagaaccct ttgagaaaac ttagattttt gtctgtacaa agtctttgcc tttttccttc 2040 ttcatttttt tccagtacat taaatttgtc aatttcatct ttgagggaaa ctgattagat 2100 gggttgtgtt tgtgttctga tggagaaaac agcaccccaa ggactcagaa gatgatttta 2160 acagttcaga acggatgtgt gcaatattgg tgcatgtaat aatgttgagt ggcagtcaaa 2220 agtcatgatt tttatcttag ttcttcatta ctgc 2254 <210> 230 <211> 4337 <212> DNA <213> Homo sapiens <400> 230 ggctgtgaca ctaatactta acatggtggt tgtgtctctt tatgcctgac tcaatcagtt 60 gaaatccaaa agtaagttct tccttgattt acctgccaag acctgagttc aggccctcag 120 ggtgctgagg ttttcctttg tgggagaaaa tgccaccaga tggcgggtta ggattgcagc 180 tccgttgaag gcgcggcccc cgctcccgaa cccccggcga ccaccccgta acaacccccc 240 cacatcggga ataacacacc ggagactttt ggggggaaac taggtcgatg gtcggcggcg 300 ccggatgggc agctgaggat tgcctttgag gttattttaa aagttttgag ttgtacagca 360 cttgattatt ttgctgcatt gtgaaaggac ctctccagca atgattactt cagaattacc 420 agtgttacag gattcaacta atgaaactac tgcccattcc gatgctggca gcgagcttga 480 agaaacagag gtcaaaggaa aaagaaaaag gggtcgtcct ggccggcctc catctacaaa 540 taagaaacct cgaaaatctc caggtgagaa gagcagaatt gaagctggaa ttagaggagc 600 aggccgtgga agagctaatg gacaccctca acagaatggg gaaggggagc ctgtcacatt 660 atttgaggtg gtgaaactgg ggaaaagtgc aatgcagtcc gtggtggatg actggattga 720 atcatataaa caagacaggg acatcgcact tctggattta atcaactttt ttatccagtg 780 ttcaggatgt cgaggtactg tgagaataga gatgtttcga aatatgcaga atgcagaaat 840 catcagaaaa atgactgaag aatttgatga ggacagtggt gattatcctc ttaccatgcc 900 tggacctcag tggaaaaaat ttcgttcaaa cttttgtgaa tttattggag tcctgattcg 960 acagtgtcag tatagcataa tttatgatga gtatatgatg gacacagtaa tctccctttt 1020 gacgggtttg tcagactccc aggtcagagc ttttaggcat acaagtaccc tggctgccat 1080 gaagctcatg actgctctgg tgaatgttgc cttaaacctc agtattcatc aggataatac 1140 ccagagacaa tatgaagccg agagaaataa aatgattggg aagagagcca atgaaaggtt 1200 ggagttacta cttcagaaac gcaaagagct gcaagaaaat caggatgaaa tcgaaaatat 1260 gatgaactct atttttaagg gtatatttgt tcatagatac cgtgatgcta ttgctgagat 1320 tagagccatt tgtattgaag aaattggagt atggatgaaa atgtatagtg atgccttcct 1380 aaatgacagt tacctaaaat atgttggctg gactcttcat gacaggcaag gggaagtcag 1440 gctgaagtgt ttgaaagctc tgcagagtct atataccaat agagaattat tccccaaatt 1500 ggaactattc actaaccgat tcaaggatcg cattgtatca atgacacttg ataaagaata 1560 tgatgttgct gtggaagcta ttcgattggt tactctgata cttcatggaa gtgaagaagc 1620 tctttccaat gaagactgtg aaaatgttta ccacttggtg tactcggcac atcgccctgt 1680 tgctgtggca gctggagagt tccttcacaa aaagctattt agcagacatg acccacaagc 1740 agaagaagca ttagcaaaga ggaggggaag aaacagcccg aatggaaacc tcattaggat 1800 gctggttctt ttctttcttg aaagtgagtt acatgaacat gcagcctact tggtggacag 1860 tttatgggag agctctcaag aactgttgaa agactgggaa tgtatgacag agttgctatt 1920 agaagaacct gttcaaggag aggaagcaat gtctgatcgt caagagagtg ctcttataga 1980 gctaatggtt tgtacaattc gtcaagctgc tgaggcacat cctccagtgg gaaggggtac 2040 cggcaagaga gtgctaactg ccaaagaaag gaaaactcaa attgatgata gaaacaaatt 2100 gactgaacat tttattatta cacttcctat gttactgtca aagtattctg cagatgcaga 2160 gaaggtagca aacttgctac aaatcccaca gtattttgat ttagaaatct acagcacagg 2220 tagaatggaa aagcatctgg atgctttatt aaaacagatt aagtttgttg tggagaaaca 2280 cgtagaatca gatgttctag aagcctgcag taaaacctat agtatcttat gcaatgaaga 2340 atataccatc cagaacagag ttgacatagc tcgaagccag ctgattgatg agtttgtaga 2400 tcgattcaat cattctgtgg aagacctatt gcaagaggga gaagaagctg atgatgatga 2460 catttacaat gttctttcta cattaaagcg gttaacttct tttcagaatg cacatgatct 2520 cacaaaatgg gatctctttg gtaattgcta cagattattg aagactggaa ttgaacatgg 2580 agccatgcca gaacagatag tcgtgcaagc actgcagtgt tcccattatt cgattctttg 2640 gcagttggtg aaaattactg atggctctcc ttccaaagag gatttgttgg tattgaggaa 2700 aacggtgaaa tcctttttgg ctgtttgcca gcagtgcctg tctaatgtta atactccagt 2760 gaaagaacag gctttcatgt tactctgtga tcttctgatg attttcagcc accaattaat 2820 gacaggtggc agagagggcc ttcagccttt ggtgttcaat ccagatactg gactccaatc 2880 tgaactcctc agttttgtga tggatcacgt ttttattgac caagacgagg agaaccagag 2940 catggagggt gatgaagaag atgaagctaa taaaattgag gccttacata aaagaaggaa 3000 tctacttgct gctttcagca aacttatcat ttatgacatt gttgacatgc atgcagctgc 3060 agacatcttc aaacactaca tgaagtatta caatgactat ggtgatatta ttaaggaaac 3120 actgagtaaa accaggcaga ttgataaaat tcagtgtgcc aagactctca ttctcagttt 3180 gcaacagtta tttaatgaac ttgttcaaga gcaaggtccc aacctagata ggacatctgc 3240 ccatgtcagt ggcattaaag aactggcacg tcgctttgcc cttacatttg gattggacca 3300 gattaagaca cgagaagcag ttgccacact tcacaaggat ggcatagagt ttgcatttaa 3360 ataccaaaat cagaaaggac aagagtatcc acctcctaat ctggcttttc ttgaagtact 3420 aagtgaattt tcttctaaac ttcttcgaca ggacaaaaag acagttcatt catacctaga 3480 gaaattcctt accgagcaga tgatggaaag gagggaggat gtatggcttc cactcatctc 3540 ctatagaaat tcattagtca ctgggggtga agatgataga atgtctgtga acagtggaag 3600 tagcagcagc aaaacctcat cagtaaggaa taagaaagga cgacctccac ttcataaaaa 3660 acgagtagaa gatgagagtc tggataacac atggctaaac aggactgaca ccatgattca 3720 gactcctggc cccctgccag caccacaact cacatccact gtactgcggg agaacagtcg 3780 gcccatggga gaccagattc aagaacctga gtctgaacat ggttctgaac cagacttttt 3840 acacaatcct cagatgcaga tctcttggtt aggccagccg aagttagaag acttaaatcg 3900 gaaggacaga acaggaatga actacatgaa agtgagaact ggagtgaggc atgctgttcg 3960 gggtctaatg gaggaagatg ctgagcccat ctttgaagat gtgatgatgt catcccgaag 4020 ccagttagaa gatatgaatg aagaatttga ggacaccatg gttattgatc tgcctccatc 4080 aagaaatcgg cgagagagag ctgagctaag gccagacttc tttgactctg cagctatcat 4140 agaagatgat tcaggatttg gaatgcctat gttctgaagt ctgaagaaaa tttacaaatc 4200 tggaactcta ttatttagag ctagaggcct atatactgtg atagcttgta tggggaaaaa 4260 caacttttga tgtgatctga tttgtttttt aatcaaatga ttaaggtcaa tccctttttg 4320 cagtgacaga agaggag 4337 <210> 231 <211> 4337 <212> DNA <213> Homo sapiens <400> 231 ggctgtgaca ctaatactta acatggtggt tgtgtctctt tatgcctgac tcaatcagtt 60 gaaatccaaa agtaagttct tccttgattt acctgccaag acctgagttc aggccctcag 120 ggtgctgagg ttttcctttg tgggagaaaa tgccaccaga tggcgggtta ggattgcagc 180 tccgttgaag gcgcggcccc cgctcccgaa cccccggcga ccaccccgta acaacccccc 240 cacatcggga ataacacacc ggagactttt ggggggaaac taggtcgatg gtcggcggcg 300 ccggatgggc agctgaggat tgcctttgag gttattttaa aagttttgag ttgtacagca 360 cttgattatt ttgctgcatt gtgaaaggac ctctccagca atgattactt cagaattacc 420 agtgttacag gattcaacta atgaaactac tgcccattcc gatgctggca gcgagcttga 480 agaaacagag gtcaaaggaa aaagaaaaag gggtcgtcct ggccggcctc catctacaaa 540 taagaaacct cgaaaatctc caggtgagaa gagcagaatt gaagctggaa ttagaggagc 600 aggccgtgga agagctaatg gacaccctca acagaatggg gaaggggagc ctgtcacatt 660 atttgaggtg gtgaaactgg ggaaaagtgc aatgcagtcc gtggtggatg actggattga 720 atcatataaa caagacaggg acatcgcact tctggattta atcaactttt ttatccagtg 780 ttcaggatgt cgaggtactg tgagaataga gatgtttcga aatatgcaga atgcagaaat 840 catcagaaaa atgactgaag aatttgatga ggacagtggt gattatcctc ttaccatgcc 900 tggacctcag tggaaaaaat ttcgttcaaa cttttgtgaa tttattggag tcctgattcg 960 acagtgtcag tatagcataa tttatgatga gtatatgatg gacacagtaa tctccctttt 1020 gacgggtttg tcagactccc aggtcagagc ttttaggcat acaagtaccc tggctgccat 1080 gaagctcatg actgctctgg tgaatgttgc cttaaacctc agtattcatc aggataatac 1140 ccagagacaa tatgaagccg agagaaataa aatgattggg aagagagcca atgaaaggtt 1200 ggagttacta cttcagaaac gcaaagagct gcaagaaaat caggatgaaa tcgaaaatat 1260 gatgaactct atttttaagg gtatatttgt tcatagatac cgtgatgcta ttgctgagat 1320 tagagccatt tgtattgaag aaattggagt atggatgaaa atgtatagtg atgccttcct 1380 aaatgacagt tacctaaaat atgttggctg gactcttcat gacaggcaag gggaagtcag 1440 gctgaagtgt ttgaaagctc tgcagagtct atataccaat agagaattat tccccaaatt 1500 ggaactattc actaaccgat tcaaggatcg cattgtatca atgacacttg ataaagaata 1560 tgatgttgct gtggaagcta ttcgattggt tactctgata cttcatggaa gtgaagaagc 1620 tctttccaat gaagactgtg aaaatgttta ccacttggtg tactcggcac atcgccctgt 1680 tgctgtggca gctggagagt tccttcacaa aaagctattt agcagacatg acccacaagc 1740 agaagaagca ttagcaaaga ggaggggaag aaacagcccg aatggaaacc tcattaggat 1800 gctggttctt ttctttcttg aaagtgagtt acatgaacat gcagcctact tggtggacag 1860 tttatgggag agctctcaag aactgttgaa agactgggaa tgtatgacag agttgctatt 1920 agaagaacct gttcaaggag aggaagcaat gtctgatcgt caagagagtg ctcttataga 1980 gctaatggtt tgtacaattc gtcaagctgc tgaggcacat cctccagtgg gaaggggtac 2040 cggcaagaga gtgctaactg ccaaagaaag gaaaactcaa attgatgata gaaacaaatt 2100 gactgaacat tttattatta cacttcctat gttactgtca aagtattctg cagatgcaga 2160 gaaggtagca aacttgctac aaatcccaca gtattttgat ttagaaatct acagcacagg 2220 tagaatggaa aagcatctgg atgctttatt aaaacagatt aagtttgttg tggagaaaca 2280 cgtagaatca gatgttctag aagcctgcag taaaacctat agtatcttat gcaatgaaga 2340 atataccatc cagaacagag ttgacatagc tcgaagccag ctgattgatg agtttgtaga 2400 tcgattcaat cattctgtgg aagacctatt gcaagaggga gaagaagctg atgatgatga 2460 catttacaat gttctttcta cattaaagcg gttaacttct tttcagaatg cacatgatct 2520 cacaaaatgg gatctctttg gtaattgcta cagattattg aagactggaa ttgaacatgg 2580 agccatgcca gaacagatag tcgtgcaagc actgcagtgt tcccattatt cgattctttg 2640 gcagttggtg aaaattactg atggctctcc ttccaaagag gatttgttgg tattgaggaa 2700 aacggtgaaa tcctttttgg ctgtttgcca gcagtgcctg tctaatgtta atactccagt 2760 gaaagaacag gctttcatgt tactctgtga tcttctgatg attttcagcc accaattaat 2820 gacaggtggc agagagggcc ttcagccttt ggtgttcaat ccagatactg gactccaatc 2880 tgaactcctc agttttgtga tggatcacgt ttttattgac caagacgagg agaaccagag 2940 catggagggt gatgaagaag atgaagctaa taaaattgag gccttacata aaagaaggaa 3000 tctacttgct gctttcagca aacttatcat ttatgacatt gttgacatgc atgcagctgc 3060 agacatcttc aaacactaca tgaagtatta caatgactat ggtgatatta ttaaggaaac 3120 actgagtaaa accaggcaga ttgataaaat tcagtgtgcc aagactctca ttctcagttt 3180 gcaacagtta tttaatgaac ttgttcaaga gcaaggtccc aacctagata ggacatctgc 3240 ccatgtcagt ggcattaaag aactggcacg tcgctttgcc cttacatttg gattggacca 3300 gattaagaca cgagaagcag ttgccacact tcacaaggat ggcatagagt ttgcatttaa 3360 ataccaaaat cagaaaggac aagagtatcc acctcctaat ctggcttttc ttgaagtact 3420 aagtgaattt tcttctaaac ttcttcgaca ggacaaaaag acagttcatt catacctaga 3480 gaaattcctt accgagcaga tgatggaaag gagggaggat gtatggcttc cactcatctc 3540 ctatagaaat tcattagtca ctgggggtga agatgataga atgtctgtga acagtggaag 3600 tagcagcagc aaaacctcat cagtaaggaa taagaaagga cgacctccac ttcataaaaa 3660 acgagtagaa gatgagagtc tggataacac atggctaaac aggactgaca ccatgattca 3720 gactcctggc cccctgccag caccacaact cacatccact gtactgcggg agaacagtcg 3780 gcccatggga gaccagattc aagaacctga gtctgaacat ggttctgaac cagacttttt 3840 acacaatcct cagatgcaga tctcttggtt aggccagccg aagttagaag acttaaatcg 3900 gaaggacaga acaggaatga actacatgaa agtgagaact ggagtgaggc atgctgttcg 3960 gggtctaatg gaggaagatg ctgagcccat ctttgaagat gtgatgatgt catcccgaag 4020 ccagttagaa gatatgaatg aagaatttga ggacaccatg gttattgatc tgcctccatc 4080 aagaaatcgg cgagagagag ctgagctaag gccagacttc tttgactctg cagctatcat 4140 agaagatgat tcaggatttg gaatgcctat gttctgaagt ctgaagaaaa tttacaaatc 4200 tggaactcta ttatttagag ctagaggcct atatactgtg atagcttgta tggggaaaaa 4260 caacttttga tgtgatctga tttgtttttt aatcaaatga ttaaggtcaa tccctttttg 4320 cagtgacaga agaggag 4337 <210> 232 <211> 3449 <212> DNA <213> Homo sapiens <400> 232 gtgaaagaac aggctttcat gttactctgt gatcttctga tgattttcag ccaccaatta 60 atgacaggtg gcagagaggg ccttcagcct ttggtgttta atccagatac tggactccaa 120 tctgaactcc tcagttttgt gatggatcac gtttttattg accaagacga ggagaaccag 180 agcatggagg gtgatgaaga agatgaagct aataaaattg aggccttaca taaaagaagg 240 aatctacttg ctgctttcag caaacttatc atttatgaca ttgttgacat gcatgcagct 300 gcagacatct tcaaacacta catgaagtat tacaatgact atggtgatat tattaaggaa 360 acactgagta aaaccaggca gattgataaa attcagtgtg ccaagactct cattctcagt 420 ttgcaacagt tatttaatga acttgttcaa gagcaaggtc ccaacctaga taggacatct 480 gcccatgtca gtggcattaa agaactggca cgtcgctttg cccttacatt tggattggac 540 cagattaaga cacgagaagc agttgccaca cttcacaagg atggcataga gtttgcattt 600 aaataccaaa atcagaaagg acaagagtat ccacctccta atctggcttt tcttgaagta 660 ctaagtgaat tttcttctaa acttcttcga caggacaaaa agacagttca ttcataccta 720 gagaaattcc ttaccgagca gatgatggaa aggagggagg atgtatggct tccactcatc 780 tcctatagaa attcattagt cactgggggt gaagatgata gaatgtctgt gaacagtgga 840 agtagcagca gcaaaacctc atcagtaagg aataagaaag gacgacctcc acttcataaa 900 aaacgagtag aagatgagag tctggataac acatggctaa acaggactga caccatgatt 960 cagactcctg gccccctgcc agcaccacaa ctcacatcca ctgtactgcg ggagaacagt 1020 cggcccatgg gagaccagat tcaagaacct gagtctgaac atggttctga accagacttt 1080 ttacacaatc ctcagatgca gatctcttgg ttaggccagc cgaagttaga agacttaaat 1140 cggaaggaca gaacaggaat gaactacatg aaagtgagaa ctggagtgag gcatgctgtt 1200 cggggtctaa tggaggaaga tgctgagccc atctttgaag atgtgatgat gtcatcccga 1260 agccagttag aagatatgaa tgaagaattt gaggacacca tggttattga tctgcctcca 1320 tcaagaaatc ggcgagagag agctgagcta aggccagact tctttgactc tgcagctatc 1380 atagaagatg attcaggatt tggaatgcct atgttctgaa gtctgaagaa aatttacaaa 1440 tctggaactc tattatttag agctagaggc ctatatactg tgatagcttg tatggggaaa 1500 aacacttttg atgtgatctg atttgttttt taatcaaatg attaaggtca atcccttttt 1560 gcagtgacag aagaggagca tgtaaattac ccaagggaat gttggtgaat gtcaactcag 1620 aaagactgac ctgaaaatca tttgtgtcct actattggac ttatcccaat acagatgtgt 1680 gtgtttttct ggagggagga agaaatttta aatttttaaa acagctgtca agataaacac 1740 tgttatacac ctgttttatg aaaactcaac attgagtaaa aaaaaacata tttttaactt 1800 tattttcctg ttgtacaatt taaaaaccgt tttaacattt tgccttttta tgttttaaaa 1860 gctaaccatt tttattaaac ctatgagtaa gcagctcatc ctaattgcga agagtgtttt 1920 ggagttcact ggatttggtt gacctttgtg gaacacaaat aatgaaggag cagaacattg 1980 acaagctaag atgaaattct gacatagtac atctctgcca aaaaccacac accctctgtg 2040 gatatggata tgaattccca gattttatat actcttgaat aaaaggttta tttttattta 2100 taagtgggca taaaataaga aatgtccatg cagccatttt tccaacagat gctgtacacc 2160 gttcatttta tatagactag ggagattcaa atacagtgca ttttctattg gtatttgttc 2220 tgtgcatttt tagcaacttc taccagcaaa taaagtattc tcagtaaaac gaaaatgatt 2280 ctcaagttat cagtttgctg tttttaccac ttatttcatg ccctgccaaa ttcaagttac 2340 acagacttcc attttcttaa gataatcaat catgaagaaa tcctttatca atcattcaaa 2400 agtaatttta agtgtaacat aactgtgttt acttcccatg cacttaatac ccttatgcgc 2460 taattttgtg aattaagttt actgattata gaagtatgtg ctgcatagaa gtctgtgctt 2520 agagggtgaa gttcctaagc ttaccttgaa ttacagctac atttcagtgt taaatgtgca 2580 tattaagaat aattcttttg gggaaagaaa ttatgaatct tcaggacagt ctacaatggt 2640 ttagagttac attctgccta gacttttatg acttgctgct attgttttaa aaaccccact 2700 tagtctcttc ctttctgatt tctaaagtaa gcctcagaat ttccaaacca attcatccac 2760 agctgtttct gggctggttt ttaaagtagc tgcaacagaa tcatgaggct ttcccttttt 2820 atcaaatacg aaaaacattt tttaaaattc tgcacaccca gtgatcatct tttgtgcggg 2880 aaagcaagat gatgatggat gattttattc atccttttag taaagacaca aaacattttt 2940 ctcaacattt gtacagttct gaaaaaaacc tggtcaccaa aaatatcttc tctgctaatt 3000 cagcaattct tgggctccag ttaggggagc tggggcctca ctttctccca gaattgtggg 3060 cttcactgga agtgaaggtg caggaatgac tggactgtcc accccagccc tgcctgcctg 3120 tggttttggc cagggagcaa gccatgaggt gccctggcac atgcacaaat tgatcctttg 3180 cgtgacagtc ttgtatggaa aacagatgct gacagaattg tagactacca tgccacacaa 3240 aaaggctaaa tatctactcc aatgggtttc cagttcagtt tgaagtcaat caaatttttg 3300 tattttcggt gtctccttga ttggttttgc tagtaattct gtaaattgta catttgcaat 3360 atgaggtttt ttttcctttt gtacaatttg aaactgatgc ttcacctttc ctttaataaa 3420 ctattcaaaa tcagaaaaaa aaaaaaaaa 3449 <210> 233 <211> 1342 <212> DNA <213> Homo sapiens <400> 233 aaaatgccac cagatggcgg gttaggattg cagctccgtt gaaggcgcgg cccccgctcc 60 cgaacccccg gcgaccaccc cgtaacaacc cccccacatc gggaataaca caccggagac 120 ttttgggggg aaactaggtc gatggtcggc ggcgcccgga tgggcagctg aggattgcct 180 ttgaggttat tttaaaagtt ttgagttgta cagcacttga ttattttgct gcattgtgaa 240 aggacctctc cagcaatgat tacttcagaa ttaccagtgt tacaggattc aactaatgaa 300 actactgccc attccgatgc tggcagcgag cttgaagaaa cagaggtcaa aggaaaaaga 360 aaaaggggtc gtcctggccg gcctccatct acaaataaga aacctcgaaa atctccaggt 420 gagaagagca gaattgaagc tggaattaga ggagcaggcc gtggaagagc taatggacac 480 cctcaacaga atggggaagg ggagcctgtc acattatttg aggtggtgaa actggggaaa 540 agtgcaatgc agtccgtggt ggatgactgg attgaatcat ataaacaaga cagggacatc 600 gcacttctgg atttaatcaa cttttttatc cagtgttcag gatgtcgagg tactgtgaga 660 atagagatgt ttcgaaatat gcagaatgca gaaatcatca gaaaaatgac tgaagaattt 720 gatgaggaca gtggtgatta tcctcttacc atgcctggac ctcagtggaa aaaatttcgt 780 tcaaactttt gtgaatttat tggagtcctg attcgacagt gtcagtatag cataatttat 840 gatgagtata tgatggacac agtaatctcc cttttgacgg gtttgtcaga ctcccaggtc 900 agagctttta ggcatacaag taccctggct ggacaagtct tggggactag ataaaatggg 960 caggaacatt taatcctctg cttcaaagac tatgtgcatg gacagttaca aggcagttat 1020 ggccagatat gattatcggc tttggaataa aatgctcctt gacattgctt aaatcttagc 1080 tgagaagaga gacaatcagg ttagttattt tgtagggtac agatgtgatg agttccagag 1140 cttcataagt catcagagtg gtcttatcag tagtattttt aatctgtttt ccaaatatcc 1200 cattttcctg ttatgaattc aatatgtgtc cctgttgtca gtgtttatgc attgcattta 1260 attgtatact tttacatttt tattaaaagt tttttttatc attaaaaaaa aaaaaaaaaa 1320 aaaaaaaaaa aaaaaaaaaa aa 1342 <210> 234 <211> 1842 <212> DNA <213> Homo sapiens <400> 234 ggaataccta ctgttgatca gattttcatg acaatttaac ttcccattcc ccatagtcca 60 agagggttat aaaaccagat ttagccatta ctgccttttt aaaaaattaa atgatgggag 120 tcttcctctg tcgcccaggc tggagtgcgg tggcatgatc gtggctcact gcaacctcag 180 acttctgggc tcaggtgatt ctcccgcctc ggcttcccag gtggctggga ctacaggtgc 240 atgccaccca tttaaaattt tttttttctt agagatggga gtcttgctat gtttcccggg 300 ctggtctcga atttctggcc ttaatttcct gatcctcctt ccttggtctc ctgagtaact 360 gggattacgg atgtgagcca ccgcacctgg aggccatcac tgtcttactg ttccaaccaa 420 gtggtagaac tggaaaacaa ctattctggt atattcaatt tgctgcagaa atctaccctc 480 aaattacctg tatctcacct atattaggaa gaattttaat agaatagcat tgtgactatc 540 ttactttata ttttaatgta ttagaggcat atagtatggg gattgatttt atagacctag 600 ctaatttttt cctcttttgg tctgtcttcc tttgtgctcc atgcttcctc aacttctttt 660 tccttgatgc ttttctgtct tacttcatct gtttcaacct ttttgcctta acatctcatt 720 gtgaataaaa tatacaagaa aatcatgtgc ctgatactat tatcttgctt caaaagatta 780 tttactactt tatctcttta aaaccaggca aattgtttct tatagtgtaa aggcagactt 840 accttctact cgttttttat gaagtggagg tcgtcctttc ttattcctta ctgatgaggt 900 tttgctgctg ctacttccac tgttcacaga cattctatca tcttcacccc cagtgactaa 960 tgaatttcta taggagatga gtggaagcca tacatcctcc ctcctttcca tcatctgctc 1020 ggtaaggaat ttctctaggt atgaatgact agaaacacaa tagaaacagc agtgattttc 1080 agagaagcag ttcatacatc acttactttt tcttaatctg aggctctctt tctgcaggtt 1140 ctgaagaata cctaaggaca cacattaaac tattaacagt ggtcaccttt ggaaagagag 1200 ggactgagga gttaaggttt tgtttcactt attcttggga tactttaaag caagtgagtg 1260 tattacctaa gggtgtgtat gtatgtacgg tctttcctat atttcttcct ttgcttttaa 1320 acaccaatgt taaaaaaaaa tcagaagttt agctcaaaaa gattattgag ttttcttata 1380 aagtgttcaa gccaaagcag gatttctaag atggtggagt aaggaggctg gcatgccctc 1440 tttccagcaa aacaacattt taactagtaa aaattataaa ataccgtaat ttaaagtatt 1500 tgccaattct cttaagggca tacagcaaat ggagaaatat tcattcaaga aaatctggcc 1560 gggcgccgtg gctcgcgcct gtaagtcccg gcactttggg gggccgaggt gggcggatca 1620 cttgaggaca gcagtttgag atcaacctgg cacaacccta tccctacaaa aaaaattagc 1680 cgggcgtggt ggcatgcgcc tgtggtcccg gctgctcggg aggctggggc aggggggtcg 1740 cttgaacccg ggaggcggag gttgcagtgg gccgggaccg tgccgctgca ctccagcctg 1800 ggtgacagtc tggagactcc attcaaaaaa aaaaaaaaaa aa 1842 <210> 235 <211> 4197 <212> DNA <213> Homo sapiens <400> 235 ctgcttctcc cccgccccat catctccagc gcgtggtggg ggaactgctg gggaaggcga 60 ttggcatcga tctctccatc ccttccgagg cccgacttcg gaattgtctt agaagaaaga 120 aggcaagcca ccattttacc cacgtaaata tatgaatata tttctgacat tgaggtgttc 180 cagaagatga taaagaaatg atagcagctc cagaaatacc aactgatttt aatctactac 240 aggagtcaga aacacatttt tcttctgaca cagattttga agatatcgaa ggaaaaaacc 300 aaaagcaagg caaaggcaaa acttgtaaaa aaggcaaaaa gggcccagca gaaaagggca 360 aaggtggaaa tggaggagga aaacctcctt ctggtccaaa ccgaatgaat ggtcatcacc 420 aacagaatgg agtggaaaac atgatgttgt ttgaagttgt taaaatgggc aagagtgcta 480 tgcagtcggt ggtagatgat tggatagaat catacaagca tgaccgagat atagcacttc 540 ttgaccttat caactttttt attcagtgtt caggctgtaa aggagttgtc acagcagaaa 600 tgtttagaca tatgcagaac tctgagataa ttcgaaaaat gactgaagaa ttcgatgagg 660 atagtggaga ttatccactt accatggctg gtcctcagtg gaagaagttc aaatccagtt 720 tttgtgaatt cattggcgtg ttagtacggc aatgtcaata tagtatcata tatgatgagt 780 atatgatgga tacagtcatt tcacttctta caggattgtc tgactcacaa gtcagagcat 840 ttcgacatac aagcaccctg gcagctatga agttgatgac agctttggtg aatgtggcac 900 taaatcttag cattaatatg gataatacac aaagacaata tgaagcagaa cggaataaaa 960 tgattggaaa acgagccaat gagaggctag aactcctgct acaaaagcgg aaagagcttc 1020 aggaaaatca agatgaaata gaaaatatga tgaatgcaat atttaaagga gtgtttgtac 1080 atagataccg tgatgcgata gctgaaattc gagctatttg cattgaagag attggcattt 1140 ggatgaagat gtatagtgat gcctttctta atgacagtta tttaaaatat gttggttgga 1200 ctatgcatga taagcaaggt gaagtaagac tcaaatgtct tactgctcta caagggcttt 1260 attataacaa agagcttaat tccaaactgg aactttttac cagtcggttc aaggatagaa 1320 ttgtgtctat gacccttgac aaagaatatg atgttgcagt acaagcaata aaattactca 1380 ctcttgtttt acagagtagt gaagaagttc tcactgcaga agattgtgaa aatgtctatc 1440 atctggttta ttcagctcac cggccagtag cagtagcagc tggagaattt ctctacaaaa 1500 agctcttcag tcgtagagat ccagaggagg atggaatgat gaaaagaaga ggaagacaag 1560 gtccaaatgc caaccttgtt aagacattgg tttttttctt tctagaaagt gagttacatg 1620 agcatgcagc ataccttgtg gatagcatgt gggactgtgc tactgagctg ctgaaagact 1680 gggaatgtat gaatagcttg ttactggaag agccacttag tggagaggaa gcactaacag 1740 ataggcaaga gagtgctctg attgaaataa tgctttgtac cattagacaa gcggctgaat 1800 gtcatcctcc cgtgggaaga gggacaggaa aaagggtgct tacagcaaag gagaagaaga 1860 cacagttgga tgataggaca aaaatcactg agctttttgc cgtggccctt cctcagttat 1920 tagcaaaata ctctgtagat gcagaaaagg tgactaactt gttgcagttg cctcagtact 1980 ttgatttgga aatatatacc actggacgat tagaaaagca tttggatgcc ttattgcgac 2040 agatccggaa tattgtagag aagcacacag atacagatgt tttggaagca tgttctaaaa 2100 cttaccatgc actctgtaat gaagagttca caatcttcaa cagagtagat atttcaagaa 2160 gtcaactgat agatgaattg gcagataaat ttaaccggct tcttgaagat tttctgcaag 2220 agggtgaaga acctgatgaa gatgatgcat atcaggtatt gtcaacattg aagaggatca 2280 ctgcttttca taatgcccat gacctttcaa agtgggattt atttgcttgt aattacaaac 2340 tcttgaaaac tggaatcgaa aatggagaca tgcctgagca gattgttatt cacgcactgc 2400 agtgtactca ctatgtaatc ctttggcaac ttgctaagat aactgaaagc agctctacaa 2460 aggaggactt gctgcgttta aagaaacaaa tgagagtatt ttgtcagata tgtcaacatt 2520 acctgaccaa cgtgaatact actgttaagg aacaggcctt cactattctg tgtgatattt 2580 tgatgatctt cagccatcag attatgtcag gagggcgtga catgttagag ccattagtgt 2640 atacccctga ttcttcattg cagtctgagt tgctcagctt tattttggat catgtcttca 2700 ttgaacagga tgatgataat aatagtgcag atggtcagca agaggatgaa gccagtaaaa 2760 ttgaagctct gcacaagaga agaaatttac ttgcagcatt ttgtaagcta attgtatata 2820 ctgtggtgga gatgaataca gctgcagata tcttcaaaca gtatatgaag tattataatg 2880 actatggaga tatcatcaaa gaaacaatga gtaaaacaag gcagatagac aaaattcagt 2940 gtgctaagac ccttattctc agtctgcaac agctttttaa tgaaatgata caagaaaatg 3000 gctataattt tgatagatca tcctctacat ttagtggcat aaaagaactt gctcgacgtt 3060 ttgctttaac ttttggactt gatcagttga aaacaagaga agccattgcc atgctacaca 3120 aagatggcat agaatttgct tttaaagagc ctaatccgca aggggagagc catccacctt 3180 taaatttggc atttcttgat attctgagtg aattttcttc taaactactt cgacaagaca 3240 aaagaacagt gtatgtttac ttggaaaagt tcatgacctt tcagatgtca ctccgaagag 3300 aggatgtgtg gcttccactg atgtcttacc gaaattcttt gctagctggt ggtgatgatg 3360 acaccatgtc agtcattagt ggaatcagca gccgggggtc aacagtacgg agtaaaaaat 3420 caaaaccatc tacaggaaaa cggaaagtgg ttgagggcat gcagctttca ctcactgaag 3480 aaagtagtag tagtgacagt atgtggttaa gcagagaaca aacactgcac acccctgtta 3540 tgatgcagac accacaactc acctccacta ttatgagaga gcccaaaaga ttacggcctg 3600 aggatagctt catgagtgtt tatccaatgc agactgaaca tcatcaaaca cctcttgatt 3660 ataatcggcg tggcacaagc ctaatggaag atgatgaaga gccaattgtg gaagatgtta 3720 tgatgtcctc agaagggagg attgaggatc ttaatgaggg aatggatttt gacaccatgg 3780 atatagattt gccaccatca aagaacagac gagagagaac agaactgaag cctgatttct 3840 ttgatccagc ttcaattatg gatgaatcag ttcttggagt gtcaatgttt taataccagt 3900 acacaattaa atctgtggtg aagtcatttt ctaagtggaa gaggaaattt taaagtgtgg 3960 tagatacagt gaaattctgt acagattttt ctctaaggag aatatgacat gcttatgctt 4020 accaagatca agtgcattga ggggcagttt tgtttgcctg aataaacgta aaggacaagt 4080 aaacaatttg atgataagct acagtttttc ttagaaagta aatattttat ttatgcgctg 4140 ttagttggct tttgaatcga ttatttcatg ctttttttta aaaaaaaaaa aaaaaaa 4197 <210> 236 <211> 5810 <212> DNA <213> Homo sapiens <400> 236 ttcatgtgac gggcccctct gcttctcccc cgccccatca tctccagcgc gtggtggggg 60 aactgctggg gaaggcgatt ggcatcgatc tctccatccc ttccgaggcc cgacttcgga 120 attgtcttag aagaaagaag gcaagccacc attttaccca cgtaaatata tgaatatatt 180 tctgacattg aggtgttcca gaagatgata aagaaatgat agcagctcca gaaataccaa 240 ctgattttaa tctactacag gagtcagaaa cacatttttc ttctgacaca gattttgaag 300 atatcgaagg aaaaaaccaa aagcaaggca aaggcaaaac ttgtaaaaaa ggcaaaaagg 360 gcccagcaga aaagggcaaa ggtggaaatg gaggaggaaa acctccttct ggtccaaacc 420 gaatgaatgg tcatcaccaa cagaatggag tggaaaacat gatgttgttt gaagttgtta 480 aaatgggcaa gagtgctatg cagtcggtgg tagatgattg gatagaatca tacaagcatg 540 accgagatat agcacttctt gaccttatca acttttttat tcagtgttca ggctgtaaag 600 gagttgtcac agcagaaatg tttagacata tgcagaactc tgagataatt cgaaaaatga 660 ctgaagaatt cgatgaggat agtggagatt atccacttac catggctggt cctcagtgga 720 agaagttcaa atccagtttt tgtgaattca ttggcgtgtt agtacggcaa tgtcaatata 780 gtatcatata tgatgagtat atgatggata cagtcatttc acttcttaca ggattgtctg 840 actcacaagt cagagcattt cgacatacaa gcaccctggc agctatgaag ttgatgacag 900 ctttggtgaa tgtggcacta aatcttagca ttaatatgga taatacacaa agacaatatg 960 aagcagaacg gaataaaatg attggaaaac gagccaatga gaggctagaa ctcctgctac 1020 aaaagcggaa agagcttcag gaaaatcaag atgaaataga aaatatgatg aatgcaatat 1080 ttaaaggagt gtttgtacat agataccgtg atgcgatagc tgaaattcga gctatttgca 1140 ttgaagagat tggcatttgg atgaagatgt atagtgatgc ctttcttaat gacagttatt 1200 taaaatatgt tggttggact atgcatgata agcaaggtga agtaagactc aaatgtctta 1260 ctgctctaca agggctttat tataacaaag agcttaattc caaactggaa ctttttacca 1320 gtcggttcaa ggatagaatt gtgtctatga cccttgacaa agaatatgat gttgcagtac 1380 aagcaataaa attactcact cttgttttac agagtagtga agaagttctc actgcagaag 1440 attgtgaaaa tgtctatcat ctggtttatt cagctcaccg gccagtagca gtagcagctg 1500 gagaatttct ctacaaaaag ctcttcagtc gtagagatcc agaggaggat ggaatgatga 1560 aaagaagagg aagacaaggt ccaaatgcca accttgttaa gacattggtt tttttctttc 1620 tagaaagtga gttacatgag catgcagcat accttgtgga tagcatgtgg gactgtgcta 1680 ctgagctgct gaaagactgg gaatgtatga atagcttgtt actggaagag ccacttagtg 1740 gagaggaagc actaacagat aggcaagaga gtgctctgat tgaaataatg ctttgtacca 1800 ttagacaagc ggctgaatgt catcctcccg tgggaagagg gacaggaaaa agggtgctta 1860 cagcaaagga gaagaagaca cagttggatg ataggacaaa aatcactgag ctttttgccg 1920 tggcccttcc tcagttatta gcaaaatact ctgtagatgc agaaaaggtg actaacttgt 1980 tgcagttgcc tcagtacttt gatttggaaa tatataccac tggacgatta gaaaagcatt 2040 tggatgcctt attgcgacag atccggaata ttgtagagaa gcacacagat acagatgttt 2100 tggaagcatg ttctaaaact taccatgcac tctgtaatga agagttcaca atcttcaaca 2160 gagtagatat ttcaagaagt caactgatag atgaattggc agataaattt aaccggcttc 2220 ttgaagattt tctgcaagag ggtgaagaac ctgatgaaga tgatgcatat caggtattgt 2280 caacattgaa gaggatcact gcttttcata atgcccatga cctttcaaag tgggatttat 2340 ttgcttgtaa ttacaaactc ttgaaaactg gaatcgaaaa tggagacatg cctgagcaga 2400 ttgttattca cgcactgcag tgtactcact atgtaatcct ttggcaactt gctaagataa 2460 ctgaaagcag ctctacaaag gaggacttgc tgcgtttaaa gaaacaaatg agagtatttt 2520 gtcagatatg tcaacattac ctgaccaacg tgaatactac tgttaaggaa caggccttca 2580 ctattctgtg tgatattttg atgatcttca gccatcagat tatgtcagga gggcgtgaca 2640 tgttagagcc attagtgtat acccctgatt cttcattgca gtctgagttg ctcagcttta 2700 ttttggatca tgtcttcatt gaacaggatg atgataataa tagtgcagat ggtcagcaag 2760 aggatgaagc cagtaaaatt gaagctctgc acaagagaag aaatttactt gcagcatttt 2820 gtaagctaat tgtatatact gtggtggaga tgaatacagc tgcagatatc ttcaaacagt 2880 atatgaagta ttataatgac tatggagata tcatcaaaga aacaatgagt aaaacaaggc 2940 agatagacaa aattcagtgt gctaagaccc ttattctcag tctgcaacag ctttttaatg 3000 aaatgataca agaaaatggc tataattttg atagatcatc ctctacattt agtggcataa 3060 aagaacttgc tcgacgtttt gctttaactt ttggacttga tcagttgaaa acaagagaag 3120 ccattgccat gctacacaaa gatggcatag aatttgcttt taaagagcct aatccgcaag 3180 gggagagcca tccaccttta aatttggcat ttcttgatat tctgagtgaa ttttcttcta 3240 aactacttcg acaagacaaa agaacagtgt atgtttactt ggaaaagttc atgacctttc 3300 agatgtcact ccgaagagag gatgtgtggc ttccactgat gtcttaccga aattctttgc 3360 tagctggtgg tgatgatgac accatgtcag tcattagtgg aatcagcagc cgggggtcaa 3420 cagtacggag taaaaaatca aaaccatcta caggaaaacg gaaagtggtt gagggcatgc 3480 agctttcact cactgaagaa agtagtagta gtgacagtat gtggttaagc agagaacaaa 3540 cactgcacac ccctgttatg atgcagacac cacaactcac ctccactatt atgagagagc 3600 ccaaaagatt acggcctgag gatagcttca tgagtgttta tccaatgcag actgaacatc 3660 atcaaacacc tcttgattat aatcggcgtg gcacaagcct aatggaagat gatgaagagc 3720 caattgtgga agatgttatg atgtcctcag aagggaggat tgaggatctt aatgagggaa 3780 tggattttga caccatggat atagatttgc caccatcaaa gaacagacga gagagaacag 3840 aactgaagcc tgatttcttt gatccagctt caattatgga tgaatcagtt cttggagtgt 3900 caatgtttta ataccagtac acaattaaat ctgtggtgaa gtcattttct aagtggaaga 3960 ggaaatttta aagtgtggta gatacagtga aattctgtac agatttttct ctaaggagaa 4020 tatgacatgc ttatgcttac caagatcaag tgcattgagg ggcagttttg tttgcctgaa 4080 taaacgtaaa ggacaagtaa acaatttgat gataagctac agtttttctt agaaagtaaa 4140 tattttattt atgcgctgtt agttggcttt tgaatcgatt atttcatgct tttttttaaa 4200 aaaaaaaaaa aacaaaataa caatctgaag aggcatttgg tacagatatg aattctctta 4260 catttattta ctggttgtac taaataatga tgacctctgc tggatttctg tttacatcca 4320 gaaaacaatg ttaaggatgt atttattccc ctaccctgaa gaaagtgtag gatagaattg 4380 tttttagcat tctaaattta aatgcttaaa acgtcaatca acaaaacttt gttttaaata 4440 ttgtaattgt ggagaaaagt aaacttataa gcagaacttt tacaattttt tcatctaaaa 4500 gtattttaag atatttttaa aatccaagag cttctctata cttttcagaa atatccagat 4560 gcagtgaact gccagaaggt aaccagtctc aaacatgctt atcccattat caaccctgaa 4620 agtttgcttg tcctttaaga taaaaatgta atgttgtgat attccttcca gtaatgccac 4680 tgtattttgt ctccaaataa aagaagctta ttgtagtatg tttgcagaaa aattctaaac 4740 aaaaattata cagcttatta gagtgtggga atagggatct aaattttaaa taaaattata 4800 tatatatata aattggtgct gattttataa ttgcgcagtt tgtttagttt tttcttactt 4860 ttaaattcca acttaaaatt atgaggtttc agaaatatat tgaaagttta acaatgttta 4920 aaaatagaaa agcatgagtg ttcatgcttt aaaatgattt ttaaatttgt attttatatt 4980 gttttatcta tctgtctttg caagcagtct tcaggttaaa gatacttcta acaggttaca 5040 gtacatttcc tctgtatgta aattagatgg gataatagaa ttcataaccc ataatattct 5100 ttgaaagcta agctttaaac ttcattttat gtcctttcac aaataaatta gtttaaaaca 5160 gaaagtggct acttgccatt ttgacatcaa ctcattttgc gaggcttagg cagctagaca 5220 tcgtttaaaa caaaatatta acttatatta catgtgtatc tatctattgt cagtcgtctc 5280 tcagttcttg aggtatatta ttttaatcat tccatgcctt aatatgcttg caatacaaga 5340 atatcttcag atgggtgaat accaaaaggc tttcagtttt tagtcagaaa tcaagcattg 5400 ggctgtggta gccaaaaacc ataggttagc taaaaagatc atgatacaat tattttatta 5460 agtcatggtt aataacaaat gaatccagac ttgtctaaca gattttccat caacaaatat 5520 tgttatgtgc aaaagtattg cctatgttgt tttacacacc actgcattaa ctagaactgc 5580 tgagaggact gtatatatga ttttaaacct aagttgattt tttttctcac tcttgaaagg 5640 agtacttctt tgtgaaagca gttcttacag ctttgttttc aaccagctaa aaatgtttta 5700 tatattactc taacctgttg tcctccacat tctattgtcc taattgtact gttttctgat 5760 ttgtatttat gtcttgagac agtaactttt tgaataaaaa taaacctaca 5810 <210> 237 <211> 4283 <212> DNA <213> Homo sapiens <400> 237 ggttcatgtg acgggcccct ctgcttctcc cccgccccat catctccagc gcgtggtggg 60 ggaactgctg gggaaggcga ttggcatcga tctctccatc ccttccgagg cccgacttcg 120 gtggccaccg agtactaaat tcacttggga ataaaagaaa aacataagaa aattataaga 180 gaaaggaatt gtcttagaag aaagaaggca agccaccatt ttacccacgt aaatatatga 240 atatatttct gacattgagg tgttccagaa gatgataaag aaatgatagc agctccagaa 300 ataccaactg attttaatct actacaggag tcagaaacac atttttcttc tgacacagat 360 tttgaagata tcgaaggaaa aaaccaaaag caaggcaaag gcaaaacttg taaaaaaggc 420 aaaaagggcc cagcagaaaa gggcaaaggt ggaaatggag gaggaaaacc tccttctggt 480 ccaaaccgaa tgaatggtca tcaccaacag aatggagtgg aaaacatgat gttgtttgaa 540 gttgttaaaa tgggcaagag tgctatgcag tcggtggtag atgattggat agaatcatac 600 aagcatgacc gagatatagc acttcttgac cttatcaact tttttattca gtgttcaggc 660 tgtaaaggag ttgtcacagc agaaatgttt agacatatgc agaactctga gataattcga 720 aaaatgactg aagaattcga tgaggatagt ggagattatc cacttaccat ggctggtcct 780 cagtggaaga agttcaaatc cagtttttgt gaattcattg gcgtgttagt acggcaatgt 840 caatatagta tcatatatga tgagtatatg atggatacag tcatttcact tcttacagga 900 ttgtctgact cacaagtcag agcatttcga catacaagca ccctggcagc tatgaagttg 960 atgacagctt tggtgaatgt ggcactaaat cttagcatta atatggataa tacacaaaga 1020 caatatgaag cagaacggaa taaaatgatt ggaaaacgag ccaatgagag gctagaactc 1080 ctgctacaaa agcggaaaga gcttcaggaa aatcaagatg aaatagaaaa tatgatgaat 1140 gcaatattta aaggagtgtt tgtacataga taccgtgatg cgatagctga aattcgagct 1200 atttgcattg aagagattgg catttggatg aagatgtata gtgatgcctt tcttaatgac 1260 agttatttaa aatatgttgg ttggactatg catgataagc aaggtgaagt aagactcaaa 1320 tgtcttactg ctctacaagg gctttattat aacaaagagc ttaattccaa actggaactt 1380 tttaccagtc ggttcaagga tagaattgtg tctatgaccc ttgacaaaga atatgatgtt 1440 gcagtacaag caataaaatt actcactctt gttttacaga gtagtgaaga agttctcact 1500 gcagaagatt gtgaaaatgt ctatcatctg gtttattcag ctcaccggcc agtagcagta 1560 gcagctggag aatttctcta caaaaagctc ttcagtcgta gagatccaga ggaggatgga 1620 atgatgaaaa gaagaggaag acaaggtcca aatgccgacc ttgttaagac attggttttt 1680 ttctttctag aaagtgagtt acatgagcat gcagcatacc ttgtggatag catgtgggac 1740 tgtgctactg agctgctgaa agactgggaa tgtatgaata gcttgttact ggaagagcca 1800 cttagtggag aggaagcact aacagatagg caagagagtg ctctgattga aataatgctt 1860 tgtaccatta gacaagcggc tgaatgtcat cctcccgtgg gaagagggac aggaaaaagg 1920 gtgcttacag caaaggagaa gaagacacag tcggatgata ggacaaaaat cactgagctt 1980 tttgccgtgg cccttcctca gttattagca aaatactctg tagatgcaga aaaggtgact 2040 aacttgttgc agttgcctca gtactttgat ttggaaatat ataccactgg acgattagaa 2100 aagcatttgg atgccttatt gcgacagatc cggaatattg tagagaagca cacagataca 2160 gatgttttgg aagcatgttc taaaacttac catgcactct gtaatgaaga gttcacaatc 2220 ttcaacagag tagatatttc aagaagtcaa ctgatagatg aattggcaga taaatttaac 2280 cggcttcttg aagattttct gcaagagggt gaagaacctg atgaagatga tgcatatcag 2340 gtattgtcaa cattgaagag gatcactgct tttcataatg cccatgacct ttcaaagtgg 2400 gatttatttg cttgtaatta caaactcttg aaaactggaa tcgaaaatgg agacatgcct 2460 gagcagattg ttattcacgc actgcagtgt actcactatg taatcctttg gcaacttgct 2520 aagataactg aaagcagctc tacaaaggag gacttgctgc gtttaaagaa acaaatgaga 2580 gtattttgtc agatatgtca acattacctg accaacgtga atactactgt taaggaacag 2640 gccttcacta ttctgtgtga tattttgatg atcttcagcc atcagattat gtcaggaggg 2700 cgtgacatgt tagagccatt agtgtatacc cctgattctt cattgcagtc tgagttgctc 2760 agctttattt tggatcatgt cttcattgaa caggatgatg ataataatag tgcagatggt 2820 cagcaagagg atgaagccag taaaattgaa gctctgcaca agagaagaaa tttacttgca 2880 gcattttgta agctaattgt atatactgtg gtggagatga atacagctgc agatatcttc 2940 aaacagtata tgaagtatta taatgactat ggagatatca tcaaagaaac aatgagtaaa 3000 acaaggcaga tagacaaaat tcagtgtgct aagaccctta ttctcagtct gcaacagctt 3060 tttaatgaaa tgatacaaga aaatggctat aattttgata gatcatcctc tacatttagt 3120 ggcataaaag aacttgctcg acgttttgct ttaacttttg gacttgatca gttgaaaaca 3180 agagaagcca ttgccatgct acacaaagat ggcatagaat ttgcttttaa agagcctaat 3240 ccgcaagggg agagccatcc acctttaaat ttggcatttc ttgatattct gagtgaattt 3300 tcttctaaac tacttcgaca agacaaaaga acagtgtatg tttacttgga aaagttcatg 3360 acctttcaga tgtcactccg aagagaggat gtgtggcttc cactgatgtc ttaccgaaat 3420 tctttgctag ctggtggtga tgatgacacc atgtcagtca ttagtggaat cagcagccgg 3480 gggtcaacag tacggagtaa aaaatcaaaa ccatctacag gaaaacggaa agtggttgag 3540 ggcatgcagc tttcactcac tgaagaaagt agtagtagtg acagtatgtg gttaagcaga 3600 gaacaaacac tgcacacccc tgttatgatg cagacaccac aactcacctc cactattatg 3660 agagagccca aaagattacg gcctgaggat agcttcatga gtgtttatcc aatgcagact 3720 gaacatcatc aaacacctct tgattataat cggcgtggca caagcctaat ggaagatgat 3780 gaagagccaa ttgtggaaga tgttatgatg tcctcagaag ggaggattga ggatcttaat 3840 gagggaatgg attttgacac catggatata gatttgccac catcaaagaa cagacgagag 3900 agaacagaac tgaagcctga tttctttgat ccagcttcaa ttatggatga atcagttctt 3960 ggagtgtcaa tgttttaata ccagtacaca attaaatctg tggtgaagtc attttctaag 4020 tggaagagga aattttaaag tgtggtagat acagtgaaat tctgtacaga tttttctcta 4080 aggagaatat gacatgctta tgcttaccaa gatcaagtgc attgaggggc agttttgttt 4140 gcctgaataa acgtaaagga caagtaaaca atttgatgat aagctacagt ttttcttaga 4200 aagtaaatat tttatttatg cgctgttagt tggcttttga atcgattatt tcatgctttt 4260 ttttaaaaaa aaaaaaaaaa aaa 4283 <210> 238 <211> 1939 <212> DNA <213> Homo sapiens <400> 238 aaaaaaaaaa accccccacc gctctagaac cgcgggagct tccgtccctg agtagaattc 60 gagggtgtaa agaagaggaa ggggaaaaat atcttgtacc agcccagggg tgaagaagcc 120 cccggcctga gaaagaagga ggagtggggg aggcgaacag tctcgttgct gcctctgtgt 180 acgctgaggg gggaggaatt gtcttagaag aaagaaggca agccaccatt ttacccacgt 240 aaatatatga atatatttct gacattgagg tgttccagaa gatgataaag aaatgatagc 300 agctccagaa ataccaactg attttaatct actacaggag tcagaaacac atttttcttc 360 tgacacagat tttgaagata tcgaaggaaa aaaccaaaag caaggcaaag gcaaaacttg 420 taaaaaaggc aaaaagggcc cagcagaaaa gggcaaaggt ggaaatggag gaggaaaacc 480 tccttctggt ccaaaccgaa tgaatggtca tcaccaacag aatggagtgg aaaacatgat 540 gttgtttgaa gttgttaaaa tgggcaagag tgctatgcag tcggtggtag atgattggat 600 agaatcatac aagcatgacc gagatatagc acttcttgac cttatcaact tttttattca 660 gtgttcaggc tgtaaaggag ttgtcacagc agaaatgttt agacatatgc agaactctga 720 gataattcga aaaatgactg aagaattcga tgaggatagt ggagattatc cacttaccat 780 ggctggtcct cagtggaaga agttcaaatc cagtttttgt gaattcattg gcgtgttagt 840 acggcaatgt caatatagta tcatatatga tgagtatatg atggatacag tcatttcact 900 tcttacagga ttgtctgact cacaagtcag agcatttcga catacaagca ccctggcagc 960 tatgaagttg atgacagctt tggtgaatgt ggcactaaat cttagcatta atatggataa 1020 tacacaaaga caatatgaag cagaacggaa taaaatgatt ggaaaacgag ccaatgagag 1080 gctagaactc ctgctacaaa agcggaaaga gcttcaggaa aatcaagatg aaatagaaaa 1140 tatgatgaat gcaatattta aaggagtgtt tgtacataga taccgtgatg cgatagctga 1200 aattcgagct atttgcattg aagagattgg catttggatg aagatgtata gtgatgcctt 1260 tcttaatgac agttatttaa aatatgttgg ttggactatg catgataagc aaggtgaagt 1320 aagactcaaa tgtcttactg ctctacaagg gctttattat aacaaagagc ttaattccaa 1380 actggaactt tttaccagtc ggttcaagga tagaattgtg tctatgaccc ttgacaaaga 1440 atatgatgtt gcagtacaag caataaaatt actcactctt gttttacaga gtagtgaaga 1500 agttctcact gcagaagatt gtgaaaatgt ctatcatctg gtttattcag ctcaccggcc 1560 agtagcagta gcagctggag aatttctcta caaaaagctc ttcagtcgta gagatccaga 1620 ggaggatgga atgatgaaaa gaagaggaag acaaggtcca aatgccaacc ttgttaagac 1680 attggttttt ttctttctag aaagtgagtt acatgagcat gcagcatacc ttgtggatag 1740 catgtgggac tgtgctactg agctgctgaa agactgggaa tgtatgaata gcttgttact 1800 ggaagagcca cttagtggag aggaagcact aacagatagg caagagagtg ctctgattga 1860 aataatgctt tgtaccgtta gacaagcggc tgaatgtcat cctcccgtgg gaagagggac 1920 aggaaaaagg gtgcttcat 1939 <210> 239 <211> 4170 <212> DNA <213> Homo sapiens <400> 239 tcaacatatg aaaaatcaat gtaatatttc atattaacag ttggaagact cacaattcat 60 agtttcagaa tttacaacac aaacctacag gaataaagac aatgtagtat tagaataagg 120 tcagatatat agatcaatgg acagaattga cagtccagaa atacacccat acgattacgg 180 tcacctgatt tttgactaag gttccaaaac aattcactag gggaaagaat agtcttgtca 240 aaaaatggtg ctcagacaag tggatagcca taagcacaga atgagtttgg acccctatct 300 caaatctcaa atacaaacat taactccgaa ttaatcaaat gcctaaattt aagagctaaa 360 attttaaagc tcttagaaga aaacataggt acacatcttt gtgactttga attaggtcac 420 ggtttccttg acatgacact taaaagtaca agcaacaaaa gaaaaaaata gataaaatga 480 acttcagcaa aattagaatg tttatgcttc agaaaacact gtgaagaaag tgatcagaca 540 actcacagaa tgggaaaaat atttgtgaat catatctctt aataagggtc cagcagaaaa 600 gggcaaaggt ggaaatggag gaggaaaacc tccttctggt ccaaaccgaa tgaatggtca 660 tcaccaacag aatggagtgg aaaacatgat gttgtttgaa gttgttaaaa tgggcaagag 720 tgctatgcag tcggtggtag atgattggat agaatcatac aagcatgacc gagatatagc 780 acttcttgac cttatcaact tttttattca gtgttcaggc tgtaaaggag ttgtcacagc 840 agaaatgttt agacatatgc agaactctga gataattcga aaaatgactg aagaattcga 900 tgaggatagt ggagattatc cacttaccat ggctggtcct cagtggaaga agttcaaatc 960 cagtttttgt gaattcattg gcgtgttagt acggcaatgt caatatagta tcatatatga 1020 tgagtatatg atggatacag tcatttcact tcttacagga ttgtctgact cacaagtcag 1080 agcatttcga catacaagca ccctggcagc tatgaagttg atgacagctt tggtgaatgt 1140 ggcactaaat cttagcatta atatggataa tacacaaaga caatatgaag cagaacgaaa 1200 taaaatgatt gggaaacgag ccaatgagag gctagaactc ctgctacaaa agcggaaaga 1260 gcttcaggaa aatcaagatg aaatagaaaa tatgatgaat gcaatattta aaggagtgtt 1320 tgtacataga taccgtgatg cgatacgtga aattcgagct atttgcattg aagagattgg 1380 catttggatg aagatgtata gtgatgcctt tcttaatgac agttatttaa aatatgttgg 1440 ttggactatg catgataagc aaggtgaagt aagactcaaa tgtcttactg ctctacaagg 1500 gctttattat aacaaagagc ttaattccaa actggaactt tttaccagtc ggttcaagga 1560 tagaattgtg tctatgaccc ttgacaaaga atatgatgtt gcagtacaag caataaaatt 1620 actcactctt gttttacaga gtagtgaaga agttctcact gcagaagatt gtgaaaatgt 1680 ctatcatctg gtttattcag ctcaccggcc agtagcagta gcagctggag aatttctcta 1740 caaaaagctc ttcagtcgta gagatccaga ggaggatgga atgatgaaaa gaagaggaag 1800 acaaggtcca aatgccaacc ttgttaagac attggttttt ttctttctag aaagtgagtt 1860 acatgagcat gcagcatacc ttgtggatag catgtgggac tgtgctactg agctgctgaa 1920 agactgggaa tgtatgaata gcttgttact ggaagagcca cttagtggag aggaagcact 1980 aacagatagg caagagagtg ctctgattga aataatgctt tgtaccatta gacaagcggc 2040 tgaatgtcat cctcccgtgg gaagagggac aggaaaaagg gtgcttacag caaaggagaa 2100 gaagacacag ttggatgata ggacaaaaat cactgagctt tttgccgtgg cccttcctca 2160 gttattagca aaatactctg tagatgcaga aaaggtgact aacttgttgc agttgcctca 2220 gtactttgat ttggaaatat ataccactgg acgattagaa aacgatttgg atgccttatt 2280 gcgacagatc cggaatattg tagagaagca cacagataca gatgttttgg aagcatgttc 2340 taaaacttac catgcactct gtaatgaaga gttcacaatc ttcaacagag tagatatttc 2400 aagaagtcaa ctgatagatg aattggcaga taaatttaac cggcttcttg aagattttct 2460 gcaagagggt gaagaacctg atgaagatga tgcatatcag gtattgtcaa cattgaagag 2520 gatcactgct tttcataatg cccatgacct ttcaaagagg gatttatttg cttgtaatta 2580 caaactcttg aaaactggaa tcgaaaatgg agacatgcct gagcagattg ttattcacgc 2640 actgcagtgt actcactatg taatcctttg gcaacttgct aagataactg aaagcagctc 2700 tacaaaggag gacttgctgc gtttaaagaa acaaatgaga gtattttgtc agatatgtca 2760 acattacctg accaacgtga atactactgt taaggaacag gccttcacta ttctgtgtga 2820 tattttgatg atcttcagcc atcagattat gtcaggaggg cgtgacatgt tagagccatt 2880 agtgtatacc cctgattctt cattgcagtc tgagttgctc agctttattt tggatcatgt 2940 cttcattgaa caggatgatg ataataatag tgcagatggt cagcaagagg atgaagccag 3000 taaaattgaa gctctgcaca agagaagaaa tttacttgca gcattttgta agctaattgt 3060 atatactgtg gtggagatga atacagctgc agatatcttc aaacagtata tgaagtatta 3120 taatgactat ggagatatca tcaaagaaac aatgagtaaa acaaggcaga tagacaaaat 3180 tcagtgtgct aagaccctta ttctcagtct gcaacagctt tttaatgaaa tgatacaaga 3240 aaatggctat aattttgata gatcatcctc tacatttagt ggcataaaag aacttgctcg 3300 acgttttgct ttaacttttg gacttgatca gttgaaaaca agagaagcca ttgccatgct 3360 acacaaagat ggcatagaat ttgcttttaa agagcctaat ccgcaagggg agagccatcc 3420 acctttaaat ttggcatttc ttgatattct gagtgaattt tcttctaaac tacttcgaca 3480 agacaaaaga acagtgtatg tttacttgga aaagttcatg acctttcaga tgtcactccg 3540 aagagaggat gtgtggcttc cactgatgtc ttaccgaaat tctttgctag ctggtggtga 3600 tgatgacacc atgtcagtca ttagtggaat cagcagccgg gggtcaacag tacggagtaa 3660 aaaatcaaaa ccatctacag gaaaacggaa agtggttgag ggcatgcagc tttcactcac 3720 tgaagaaagt agtagtagtg acagtatgtg gttaacgaga gaacaaacac tgcacacccc 3780 tgttatgatg cagacaccac aactcacctc cactattatg agagagccca aaagattacg 3840 gcctgaggat agcttcatga gtgtttatcc taagcagact gaacatcatc aaacacctct 3900 tgattataat cggcgtggca caagcctaat ggaagatgat gaagagccaa ttgtggaaga 3960 tgttatgatg tcctcagaag ggaggattga ggatcttaat gagggaatgg attttgacac 4020 catggatata gatttgccac catcaaagaa cagacgagag agaacagaac tgaagcctga 4080 tttctttgat ccagcttcaa ttatggatga atcagttctt ggagtgtcaa tgttttaata 4140 ccagtacaca attaaatctg tggtgaagtc 4170 <210> 240 <211> 4217 <212> DNA <213> Homo sapiens <400> 240 gattcatgtg acgggcccct ctgcttctcc cccgccccat catctccagc gcgtggtggg 60 ggaactgctg gggaaggcga ttggcatcga tctctccatc ccttccgagg cccgacttcg 120 gaattgtctt agaagaaagg aggcaagcca ccattttacc cacgtaaata tatgaatata 180 tttctgacat tgaggtgttc cagaagatga taaagaaatg atagcagctc cagaaatacc 240 aactgatttt aatctactac aggagtcaga aacacatttt tcttctgaca cagattttga 300 agatatcgaa ggaaaaaacc aaaagcaagg caaaggcaaa acttgtaaaa aaggcaaaaa 360 gggcccagca gaaaagggca aaggtggaaa tggaggagga aaacctcctt ctggtccaaa 420 ccgaatgaat ggtcatcacc aacagaatgg agtggaaaac atgatgttgt ttgaagttgt 480 taaaatgggc aagagtgcta tgcagtcggt ggtagatgat tggatagaat catacaagca 540 tgaccgagat atagcacttc ttgaccttat caactttttt attcagtgtt caggctgtaa 600 aggagttgtc acagcagaaa tgtttagaca tatgcagaac tctgagataa ttcgaaaaat 660 gactgaagaa ttcgatgagg atagtggaga ttatccactt accatggccg gtcctcagtg 720 gaagaagttc aaatccagtt tttgtgaatt cattggcgtg ttagtacggc aatgtcaata 780 tagtatcata tatgatgagt atatgatgga tacagtcatt tcacttctta caggattgtc 840 tgactcacaa gtcagagcat ttcgacatac aagcaccctg gcagctatga agttgatgac 900 agctttggtg aatgtggcac taaatcttag cattaatatg gataatacac aaagacaata 960 tgaagcagaa cggaataaaa tgattggaaa acgagccaat gagaggctag aactcctgct 1020 acaaaagcgg aaagagcttc aggaaaatca agatgaaata gaaaatatga tgaatgcaat 1080 atttaaagga gtgtttgtac atagataccg tgatgcgata gctgaaattc gagctatttg 1140 cattgaagag attggcattt ggatgaagat gtatagtgat gcctttctta atgacagtta 1200 tttaaaatat gttggttgga ctatgcatga taagcaaggt gaagtaagac tcaaatgtct 1260 tactgctcta caagggcttt attataacaa agagcttaat tccaaactgg aactttttac 1320 cagtcggttc aaggatagaa ttgtgtctat gacccttgac aaagaatatg atgttgcagt 1380 acaagcaata aaattactca ctcttgtttt acagagtagt gaagaagttc tcactgcaga 1440 agattgtgaa aatgtctatc atctggttta ttcagctcac cggccagtag cagtagcagc 1500 tggagaattt ctctacaaaa agctcttcag tcgtagagat ccagaggagg atggaatgat 1560 gaaaagaaga ggaagacaag gtccaaatgc caaccttgtt aagacattgg tttttttctt 1620 tctagaaagt gagttacatg agcatgcagc ataccttgtg gatagcatgt gggactgtgc 1680 tactgagctg ctgaaagact gggaatgtat gaatagcttg ttactggaag agccacttag 1740 tggagaggaa gcactaacag ataggcaaga gagtgctctg attgaaataa tgctttgtac 1800 cattagacaa gcggctgaat gtcatcctcc cgtgggaaga gggacaggaa aaagggtgct 1860 tacagcaaag gagaagaaga cacagttgga tgataggaca aaaatcactg agctttttgc 1920 cgtggccctt cctcagttat tagcaaaata ctctgtagat gcagaaaagg tgactaactt 1980 gttgcagttg cctcagtact ttgatttgga aatatatacc actggacgat tagaaaagca 2040 tttggatgcc ttattgcgac agatccggaa tattgtagag aagcacacag atacagatgt 2100 tttggaagca tgttctaaaa cttaccatgc actctgtaat gaagagtcca caatcttcaa 2160 cagagtagag atttcaagaa gtcaactgat agatgaattg gcagataaat ttaaccggct 2220 tcttgaagat tttctgcaag agggtgaaga acctgatgaa gatgatgcat atcaggtatt 2280 gtcaacattg aagaggatca ctgcttttca taatgcccat gacctttcaa agtgggattt 2340 atttgcttgt aattacaaac tcttgaaaac tggaatcgaa aatggagaca tgcctgagca 2400 gattgttatt cacgcactgc agtgtactca ctatgtaatc ctttggcaac ttgctaagat 2460 aactgaaagc atctctacaa aggaggactt gctgcgttta aagaaacaaa tgagagtatt 2520 ttgtcagata tgtcaacatt acctgaccaa cgtgaatact actgttaagg aacaggcctt 2580 cactattctg tgtgatattt tgatgatctt cagccatcag attatgtcag gagggcgtga 2640 catgttagag ccattagtgt atacccctga ttcttcattg cagtctgagt tgctcagctt 2700 tattttggat catgtcttca ttgaacagga tgatgataat aatagtgcag atggtcagca 2760 agaggatgaa gccagtaaaa ttgaagctct gcacaagaga agaaatttac ttgcagcatt 2820 ttgtaagcta attgtatata ctgtggtgga gatgaataca gctgcagata tcttcaaaca 2880 gtatatgaag tattataatg actatggaga tatcatcaaa gaaacaatga gtaaaacaag 2940 gcagatagac aaaattcagt gtgctaagac ccttattctc agtctgcaac agctttttaa 3000 tgaaatgata caagaaaatg gctataattt tgatagatca tcctctacat ttagtggcat 3060 aaaagaactt gctcgacgtt ttgctttaac ttttggactt gatcagttga aaacaagaga 3120 agccattgcc atgctacaca aagatggcat agaatttgct tttaaagagc ctaatccgca 3180 aggggagagc catccacctt taaatttggc atttcttgat attctgagtg aattttcttc 3240 taaactactt cgacaagaca aaagaacagt gtatgtttac ttggaaaagt tcatgacctt 3300 tcagatgtca ctccgaagag aggatgtgtg gcttccactg atgtcttacc gaaattcttt 3360 gctagctggt ggtgatgatg acaccatgtc agtcattagt ggaatcagca gccgggggtc 3420 aacagtacgg agtaaaaaat caaaaccatc tacaggaaaa cggaaagtgg ttgagggcat 3480 gcagctttca ctcactgaag aaagtagtag tagtgacagt atgtggttaa gcagagaaca 3540 aacactgcac acccctgtta tgatgcagac accacaactc acctccacta ttatgagaga 3600 gcccaaaaga ttacggcctg aggatagctt catgagtgtt tatccaatgc agactgaaca 3660 tcatcaaaca cctcttgatt ataatcggcg tggcacaagc ctaatggaag atgatgaaga 3720 gccaattgtg gaagatgtta tgatgtcctc agaagggagg attgaggatc ttaatgaggg 3780 aatggatttt gacaccatgg atatagattt gccaccatca aagaacagac gagagagaac 3840 agaactgaag cctgatttct ttgatccagc ttcaattatg gatgaatcag ttcttggagt 3900 gtcaatgttt taataccagt acacaattaa atctgtggtg aagtcatttt ctaagtggaa 3960 gaggaaattt taaagtgtgg tagatacagt gaaattctgt acagattttt ctctaaggag 4020 aatatgacat gcttatgctt accaagatca agtgcattga ggggcagttt tgtttgcctg 4080 aataaacgta aaggacaagt aaacaatttg atgataagct acagtttttc ttagaaagta 4140 aatattttat ttatgcgctg ttagttggcc tttgaatcga ttatttcatg ctttttttaa 4200 aaaaaaaaaa aaaaaaa 4217 <210> 241 <211> 5047 <212> DNA <213> Homo sapiens <400> 241 gggagcttcc gtccctgagt agaattcgag ggtgtaaaga agaggaaggg gaaaaatatc 60 ttgtaccagc ccaggggtga agaagccccc ggcctgagaa agaaggagga gtgggggagg 120 cgaacagtct cgttgctgcc tctgtgtacg ctgagggggg aggtggccac cgagtactaa 180 attcacttgg gaataaaaga aaaacataag aaaattataa gagaaaggaa ttgtcttaga 240 agaaagaagg caagccacca ttttacccac gtaaatatat gaatatattt ctgacattga 300 ggtgttccag aagatgataa agaaatgata gcagctccag aaataccaac tgattttaat 360 ctactacagg agtcagaaac acatttttct tctgacacag attttgaaga tatcgaagga 420 aaaaaccaaa agcaaggcaa aggcaaaact tgtaaaaaag gcaaaaaggg cccagcagaa 480 aagggcaaag gtggaaatgg aggaggaaaa cctccttctg gtccaaaccg aatgaatggt 540 catcaccaac agaatggagt ggaaaacatg atgttgtttg aagttgttaa aatgggcaag 600 agtgctatgc agtcggtggt agatgattgg atagaatcat acaagcatga ccgagatata 660 gcacttcttg accttatcaa cttttttatt cagtgttcag gctgtaaagg agttgtcaca 720 gcagaaatgt ttagacatat gcagaactct gagataattc gaaaaatgac tggagaattc 780 gatgaggata gtggagatta tccacttacc atggctggtc ctcagtggaa gaagttcaaa 840 tccagttttt gtgaattcat tggcgtgtta gtacggcaat gtcaatatag tatcatatat 900 gatgagtata tgatggatac agtcatttca cttcttacag gattgtctga ctcacaagtc 960 agagcatttc gacatacaag caccctggca gctatgaagt tgatgacagc tttggtgaat 1020 gtggcactaa atcttagcat taatatggat aatacacaaa gacaatatga agcagaacgg 1080 aataaaatga ttggaaaacg agccaatgag aggctagaac tcctgctaca aaagcggaaa 1140 gagcttcagg aaaatcaaga tgaaatagaa aatatgatga atgcaatatt taaaggagtg 1200 tttgtacata gataccgtga tgcgatagct gaaattcgag ctatttgcat tgaagagatt 1260 ggcatttgga tgaagatgta tagtgatgcc tttcttaatg acagttattt aaaatatgtt 1320 ggttggacta tgcatgataa gcaaggtgaa gtaagactca aatgtcttac tgctctacaa 1380 gggctttatt ataacaaaga gcttaattcc aaactggaac tttttaccag tcggctcaag 1440 gatagaattg tgtctatgac ccttgacaaa gaatatgatg ttgcagtaca agcaataaaa 1500 ttactcactc ttgttttaca gagtagtgaa gaagttctca ctgcagaaga ttgtgaaaat 1560 gtctatcatc tggtttattc agctcaccgg ccagtagcag tagcagctgg agaatttctc 1620 tacaaaaagc tcttcagtcg tagagatcca gaggaggatg gaatgatgaa aagaagagga 1680 agacaaggtc caaatgccaa ccttgttaag acattggttt ttttctttct agaaagtgag 1740 ttacatgagc atgcagcata ccttgtggat agcatgtggg actgtgctac tgagctgctg 1800 aaagactggg aatgtatgaa tagcttgtta ctggaagagc cacttagtgg agaggaagca 1860 ctaacagata ggcaagagag tgctctgatt gaaataatgc tttgtaccat tagacaagcg 1920 gctgaatgtc atcctcccgt gggaagaggg acaggaaaaa gggtgcttac agcaaaggag 1980 aagaagacac agttggatga taggacaaaa atcactgagc tttttgccgt ggcccttcct 2040 cagttattag caaaatactc tgtagatgca gaaaaggtga ctaacttgtt gcagttgcct 2100 cagtactttg atttggaaat atataccact ggacgattag aaaagcattt ggatgcctta 2160 ttgcgacaga tccggaatat tgtagagaag cacacagata cagatgtttt ggaagcatgt 2220 tctaaaactt accatgcact ctgtaatgaa gagttcacaa tcttcaacag agtagatatt 2280 tcaagaagtc aactgataga tgaattggca gataaattta actggcttct tgaagatttt 2340 ctgcaagagg gtgaagaacc tgatgaagat gatgcatatc aggtattgtc aacattgaag 2400 aggatcactg cttttcataa tgcccatgac ctttcaaagt gggatttatt tgcttgtaat 2460 tacaaactct tgaaaactgg aatcgaaaat ggagacatgc ctgagcagat tgttattcac 2520 gcactgcagt gtactcacta tgtaatcctt tggcaacttg ctaagataac tgaaagcagc 2580 tctacaaagg aggacttgct gcgtttaaag aaacaaatga gagtattttg tcagatatgt 2640 caacattacc tgaccaacgt gaatactact gttaaggaac aggccttcac tattctgtgt 2700 gatattttga tgatcttcag ccatcagatt atgtcaggag ggcgtgacat gttagagcca 2760 ttagtgtata cccctgattc ttcattgcag tctgagttgc tcagctttat tttggatcat 2820 gtcttcattg aacaggatga tgataataat agtgcagatg gtcagcaaga ggatgaagcc 2880 agtaaaattg aagctctgca caagagaaga aatttacttg cagcattttg taagctaatt 2940 gtatatactg tggtggagat gaatacagct gcagatatct tcaaacagta tatgaagtat 3000 tataatgact atggagatat catcaaagaa acaatgagta aaacaaggca gatagacaaa 3060 attcagtgtg ctaagaccct tattctcagt ctgcaacagc tttttaatga aatgatacaa 3120 gaaaatggct ataattttga tagatcatcc tctacattta gtggcataaa agaacttgct 3180 cgacgttttg ctttaacttt tggacttgat cagttgaaaa caagagaagc cattgccatg 3240 ctacacaaag atggcataga atttgctttt aaagagccta atccgcaagg ggagagccat 3300 ccacctttaa atttggcatt tcttgatatt ctgagtgaat tttcttctaa actacttcga 3360 caagacaaaa gaacagtgta tgtttacttg gaaaagttca tgacctttca gatgtcactc 3420 cgaagagagg atgtgtggct tccactgatg tcttaccgaa attctttgct agctggtggt 3480 gatgatgaca ccatgtcagt cattagtgga atcagcagcc gggggtcaac agtacggagt 3540 aaaaaatcaa aaccatctac aggaaaacgg aaagtggttg agggcatgca gctttcactc 3600 actgaagaaa gtagtagtag tgacagtatg tggttaagca gagaacaaac actgcacacc 3660 cctgttatga tgcagacacc acaactcacc tccactatta tgagagagcc caaaagatta 3720 cggcctgagg atagcttcat gagtgtttat ccaatgcaga ctgaacatca tcaaacacct 3780 cttgattata acacgcaggt aacatggatg ttagctcaaa gacaacaaga ggaagcaagg 3840 caacagcagg agagagcagc aatgagctat gttaaactgc gaactaatct tcagcatgcc 3900 attcggcgtg gcacaagcct aatggaagat gatgaagagc caattgtgga agatgttatg 3960 atgtcctcag aagggaggat tgaggatctt aatgagggaa tggattttga caccatggat 4020 atagatttgc caccatcaaa gaacagacga gagagaacag aactgaagcc tgatttcttt 4080 gatccagctt caattatgga tgaatcagtt cttggagtgt caatgtttta ataccagtac 4140 acaattaaat ctgtggtgaa gtcattttct aagtggaaga ggaaatttta aagtgtggta 4200 gatacagtga aattctgtac agatttttct ctaaggagaa tatgacatgc ttatgcttac 4260 caagatcaag tgcattgagg ggcagttttg tttgcctgaa taaacgtaaa ggacaagtaa 4320 acaatttgat gataagctac agtttttctt agaaagtaaa tattttattt atgcgctgtt 4380 agttggcttt tgaatcgatt atttcatgct tttttttaaa aaaaaaaaaa acaaaataac 4440 aatctgaaga ggcatttggt acagatatga attctcttac atttatttac tggttgtact 4500 aaataatgat gacctctgct ggatttctgt ttacatccag aaaacaatgt taaggatgta 4560 tttattcccc taccctgaag aaagtgtagg atagaattgt ttttagcatt ctaaatttaa 4620 atgcttaaaa cgtcaatcaa caaaactttg ttttaaatat tgtaattgtg gagaaaagta 4680 aacttataag cagaactttt acaatttttt catctaaaag tattttaaga tatttttaaa 4740 atccaagagc ttctctatac ttttcagaaa tatccagatg cagtgaactg ccagaaggta 4800 accagtctca aacatgctta tcccattatc aaccctgaaa gtttgcttgt cctttaagat 4860 aaaaatgtaa tgttgtgata ttccttccag taatgccact gtattttgtc tccaaataaa 4920 agaagcttat tgtagtatgt ttgcagaaaa attctaaaca aaaattatac agcttattag 4980 agtgtgggaa tagggatcta aattttaaat aaaattatat atatatataa aaaaaaaaaa 5040 aaaaaaa 5047 <210> 242 <211> 5814 <212> DNA <213> Homo sapiens <400> 242 gattcatgtg acgggcccct ctgcttctcc cccgccccat catctccagc gcgtggtggg 60 ggaactgctg gggaaggcga ttggcatcga tctctccatc ccttccgagg cccgacttcg 120 gaattgtctt agaagaaaga aggcaagcca ccattttacc cacgtaaata tatgaatata 180 tttctgacat tgaggtgttc cagaagatga taaagaaatg atagcagctc cagaaatacc 240 aactgatttt aatctactac aggagtcaga aacacatttt tcttctgaca cagattttga 300 agatatcgaa ggaaaaaacc aaaagcaagg caaaggcaaa acttgtaaaa aagacaaaaa 360 gggcccagca gaaaagggca aaggtggaaa tggaggagga aaacctcctt ctggtccaaa 420 ccgaatgaat ggtcatcacc aacagaatgg agtggaaaac atgatgttgt ttgaagttgt 480 taaaatgggc aagagtgcta tgcagtcggt ggtagatgat tggatagaat catacaagca 540 tgaccgagat atagcacttc ttgaccttat caacttttta ttcagtgttc aggctgtaaa 600 ggagttgtca cagcagaaat gtttagacat atgcagaact ctgagataat tcgaaaaatg 660 actgaagaat tcgatgagga tagtggagat tatccactta ccatggctgg tcctcagtgg 720 aagaagttca aatccagttt ttgtgaattc attggcgtgt tagtacggca atgtcaatat 780 agtatcatat atgatgagta tatgatggat acagtcattt cacttcttac aggattgtct 840 gactcacaag tcagagcatt tcgacataca agcaccctgg cagctatgaa gttgatgaca 900 gctttggtga atgtggcact aaatcttagc attaatatgg ataatacaca aagacaatat 960 gaagcagaac ggaataaaat gattggaaaa cgagccaatg agaggctaga actcctgcta 1020 caaaagcgga aagagcttca ggaaaatcaa gatgaaatag aaaatatgat gaatgcaata 1080 tttaaaggag tgtttgtaca tagataccgt gatgcgatag ctgaaattcg agctatttgc 1140 attgaagaga ttggcatttg gatgaagatg tatagtgatg cctttcttaa tgacggttat 1200 ttaaaatatg ttggttggac tatgcatgat aagcaaggtg aagtaagact caaatgtctt 1260 actgctctac aagggcttta ttataacaaa gagcttaatt ccaaactgga actttttacc 1320 agtcggttca aggatagaat tgtgtctatg acccttgaca aagaatatga tgttgcagta 1380 caagcaataa aattactcac tcttgtttta cagagtagtg aagaagttct cactgcagaa 1440 gattgtgaaa atgtctatca tctggtttat tcagctcacc ggccagtagc agtagcagct 1500 ggagaatttc tctacaaaaa gctcttcagt cgtagagatc cagaggagga tggaatgatg 1560 aaaagaagag gaagacaagg tccaaatgcc aaccttgtta agacattggt ttttttcttt 1620 ctagaaagtg agttacatga gcatgcagca taccttgtgg atagcatgtg ggactgtgct 1680 actgagctgc tgaaagactg ggaatgtatg aatagcttgt tactggaaga gccacttagt 1740 ggagaggaag cactaacaga taggcaagag agtgctctga ttgaaataat gctttgtacc 1800 attagacaag cggctgaatg tcatcctccc gtgggaagag ggacaggaaa aagggtgctt 1860 acagcaaagg agaagaagac acagttggat gataggacaa aaatcactga gctttttgcc 1920 gtggcccttc ctcagttatt agcaaaatac tctgtagatg cagaaaaggt gactaacttg 1980 ttgcagttgc ctcagtactt tgatttggaa atatatacca ctggacgatt agaaaagcat 2040 ttggatgcct tattgcgaca gatccggaat attgtagaga agcacacaga tacagatgtt 2100 ttggaagcat gttctaaaac ttaccatgca ctctgtaatg aagagttcac aatcttcaac 2160 agagtagata tttcaagaag tcaactgata gatgaattgg cagataaatt taaccggctt 2220 cttgaagatt ttctgcaaga gggtgaagaa cctgatgaag atgatgcata tcaggtattg 2280 tcaacattga agaggatcac tgcttttcat aatgcccatg acctttcaaa gtgggattta 2340 tttgtttgta attacaaact cttgaaaact ggaatcgaaa atggagacat gcctgagcag 2400 attgttattc acgcactgca gtgtactcac tatgtaatcc tttggcaact tgctaagata 2460 actgaaagca gctctacaaa ggaggacttg ctgcgtttaa agaaacaaat gagagtattt 2520 tgtcagatat gtcaacatta cctgaccaac gtgaatacta ctgttaagga acaggccttc 2580 actattctgt gtgatatttt gatgatcttc agccatcaga ttatgtcagg agggcgtgac 2640 atgttagagc cattagtgta tacccctgat tcttcattgc agtctgagtt gctcagcttt 2700 attttggatc atgtcttcac tgaacaggat gatgataata atagtgcaga tggtcagcaa 2760 gaggatgaag ccagtaaaat tgaagctctg cacaagagaa gaaatttact tgcagcattt 2820 tgtaagctaa ttgtatatac tgtggtggag atgaatacag ctgcagatat cttcaaacag 2880 tatatgaagt attataatga ctatggagat atcatcaaag aaacaatgag taaaacaagg 2940 cagatagaca aaattcagtg tgctaagacc cttattctca gtctgcaaca gctttttaat 3000 gaaatgatac aagaaaatgg ctataatttt gatagatcat cctctacatt tagtggcata 3060 aaagaacttg ctcgacgttt tgctttaact tttggacttg atcagttgaa aacaagagaa 3120 gccattgcca tgctacacaa agatggcata gaatttgctt ttaaagagcc taatccgcaa 3180 ggggagagct atccaccttt aaatttggca tttcttgata ttctgagtga attttcttct 3240 aaactacttc gacaagacaa aagaacagtg tatgtttact tggaaaagtt catgaccttt 3300 cagatgtcac tccgaagaga ggatgtgtgg cttccactga tgtcttaccg aaattctttg 3360 ctagctggtg gtgatgatga caccatgtca gtcattagtg gaatcagcag ccgggggtca 3420 acagtacgga gtaaaaaatc aaaaccatct acaggaaaac ggaaagtggt tgagggcatg 3480 cagctttcac tcactgaaga aagtagtagt agtgacagta tgtggttaag cagagaacaa 3540 acactgcaca cccctgttat gatgcagaca ccacaactca cctccactat tatgagagag 3600 cccaaaagat tacggcctga ggatagcttc atgagtgttt atccaatgca gactgaacat 3660 catcaaacac ctcttgatta taatcggcgt ggcacaagcc taatggaaga tgatgaagag 3720 ccaattgtgg aagatgttat gatgtcctca gaagggagga ttgaggatct taatgaggga 3780 atggattttg acaccatgga tatagatttg ccaccatcaa agaacagacg agagagaaca 3840 gaactgaagc ctgatttctt tgatccagct tcaattatgg atgaatcagt tcttggagtg 3900 tcaatgtttt aataccagta cacaattaaa tctgtggtga agtcattttc taagtggaag 3960 aggaaatttt aaagtgtggt agatacagtg aaattctgta cagattttct ctaaggagaa 4020 tatgacatgc ttatgcttac caagatcaag tgcattgagg ggcagttttg tttgcctgaa 4080 taaacgtaaa ggacaagtaa acaatttgat gataagctac agtttttctt agaaagtaaa 4140 tatttaattt atgcgctgtt agttggcttt tgaatcgatt atttcatgct ttttttaaaa 4200 aaaaaaaaac aaaataacaa tctgaagagg catttggtac agatatgaat tctcttacat 4260 ttatttactg gttgtactaa ataatgatga cctctgctgg atttctgttt acatccagaa 4320 aacaatgtta aggatgtatt tattccccta ccctgaagaa agtgtaggat agaattgttt 4380 ttagcattct aaatttaaat gcttaaaacg tcaatcaaca aaactttgtt ttaaatattg 4440 taattgtgga gaaaagtaaa cttataagca gaacttttac aattttttca tctaaaagta 4500 ttttaagata tttttaaaat ccaagagctt ctctatactt ttcagaaata tccagatgca 4560 gtgaactgcc agaaggtaac cagtctcaaa catgcttatc ccattatcaa ccctgaaagt 4620 ttgcttgtcc tttaagataa aaatgtaatg ttgtgatatt ccttccagta atgccactgt 4680 attttgtctc caaataaaag aagcttattg tagtatgttt gcagaaaaat tctaaacaaa 4740 aattatacag cttattagag tgtgggaata gggatctaaa ttttaaataa aattatatat 4800 atatataaat tggtgctgat tttataattg cgcagtttgt ttagtttttt cttactttta 4860 aattccaact taaaattatg aggtttcaga aatatattga aagtttaaca atgtttaaaa 4920 atagaaaagc atgagtgttc atgctttaaa atgattttta aatttgtatt ttatattgtt 4980 ttatctatct gtctttgcaa gcagtcttca ggttaaagat acttctaaca ggttacagta 5040 catttcctct gtatgtaaat tagatgggat aatagaattc ataacccata atattctttg 5100 aaagctaagc tttaaacttc attttatgtc ctttcacaaa taaattagtt taaaacagaa 5160 agtggctact tgccattttg acatcaactc attttgcgag gcttaggcag ctagacatcg 5220 tttaaaacaa aatattaact tatattacat gtgtatctat ctattgtcag tcgtctctca 5280 gttcttgagg tatattattt taatcattcc atgccttaat atgcttgcaa tacaagaata 5340 tcttcagatg ggtgaatacc aaaaggcttt cagtttttag tcagaaatca agcattgggc 5400 tgtggtagcc aaaaaccata ggttagctaa aaagatcatg atacaattat tttattaagt 5460 catggttaat aacaaatgaa tccagacttg tctaacagat tttccatcaa caaatattgt 5520 tatgtgcaaa agtattgcct atgttgtttt acacaccact gcattaacta gaactgctga 5580 gaggactgta tatatgattt taaacctaag ttgatttttt ttctcactct tgaaaggagt 5640 acctccttgt gaaagcagtt cttacagctt tgttttcaac cagctaaaaa tgttttatat 5700 attactctaa cctgttgtcc tccacattct attgtcctaa ttgtactgtt ttctgatttg 5760 tatttatgtc ttgagacagt aactttttga ataaaaataa acctacagaa aaaa 5814 <210> 243 <211> 1915 <212> DNA <213> Homo sapiens <400> 243 tcttgacctc gtgatccgcc cacctgggat tacaggtgtg agcgaccatg cctggcccag 60 aaatttattt tttttatcac atttctggaa gctagaagtc ctgagatgaa ggtgatttct 120 tttgaggctt ctctccttgg cttgtagatg gctgccttct tcctttgtct ttagatggtc 180 tttcctatat gtgtctctcc tcttcttatc agggccccaa ctatattcaa ttagggccca 240 cccatatgac ctcattttac cttaattacc tctttaaagg ccctgtcgcc aaatactggc 300 atgttctgag gtactggatt aggacttcag catcatgcac attttgaagg gacataattc 360 agcccgtaac attttgcttt gtatgttgtg aattttccat aatgaaaagt ttttgtaagt 420 tttgtaaata taaatgagat catattactc caatctataa tctccctgcc cccaccttcc 480 aataactttc catctacctg ctttggggaa ttcacagagg tttatcacct agtagttaat 540 gaattctgta atttttctgt gactttaaag ggaagatatg gcctgggcat gtaggcccaa 600 agttatttat atgtattaac atgttgttta ttcatgatag tttgaaagtt ttgtgccttg 660 tttttgccaa cataattaaa agccaaaagt actgtttgtt tttaaaaaat ctatttcata 720 taaaagccag attctcttct tcctttcaaa attgactctt agcagttcca tatatttatg 780 atactgtcag aaatattagc tgattatcac aattcattgt cttaatgatc tcagaaaaaa 840 attaagaaac cgatttctct ttccagcctc catcaagaaa tcggcgagag agagctgagc 900 taaggccaga cttctttgac tctgcagcta tcatagaaga tgattcagta aatgtcaaat 960 tattactgct ttttatttat ggttcctggg tcctgtttat gcatgaaatt aataattatg 1020 tttctcatca tttttctagg gatttggaat gcctatgttc tgaagtctga agaaaattta 1080 caaatctgga actctattat ttagagctag aggcctatat actgtgatag cttgtatggg 1140 gaaaaacact tttgatgtga tctgatttgt tttttaatca aatgattaag gtcaatccct 1200 ttttgcagtg acagaagagg agcatgtaaa ttacccaagg gaatgttggt gaatgtcaac 1260 tcagaaagac tgacctgaaa atcatttgtg tcctactatt ggacttatcc caatacagat 1320 gtgtgtgttt ttctggaggg aggaagaaat tttaaatttt taaaacagct gtcaagataa 1380 acactgttat acacctgttt tatgaaaact caacattgag taaaaaaaaa catattttta 1440 actttatttt cctgttgtac aatttaaaaa ccgttttaac attttgcctt tttatgtttt 1500 aaaagctaac catttttatt aaacctatga gtaagcagct catcctaatt gcgaagagtg 1560 ttttggagtt cactggattt ggttgacctt tgtggaacac aaataatgaa ggagcagaac 1620 attgacaagc taagatgaaa ttctgacata gtacatctct gccaaaaacc acacaccctc 1680 tgtggatatg gatatgaatt cccagatttt atatactctt gaataaaagg tttattttta 1740 tttataagtg ggcataaaat aagaaatgtc catgcagcca tttttccaac agatgctgta 1800 caccgttcat tttatataga ctagggagat tcaaatacag tgcattttct attggtattt 1860 gttctgtgca tttttagcaa cttctaccag caaataaagt attctcagta aaacg 1915 <210> 244 <211> 4290 <212> DNA <213> Homo sapiens <220> <221> misc_feature <222> (3043)..(3043) <223> "n" means any of A, T, G, and C. <400> 244 ccgggccgcc cgcgtgccca agcccacgtg agagggcagg acgcctgaga gcttgaggcc 60 acacgaggct gtggagcggc gtgactcaaa cgtggcgcgc atcagctcgc acacttccaa 120 acctcgcgat agctactggc cctgggcgag ccgttgggat tgcgcttgcg cacagcgtgt 180 cttctggatc gccataccta ccctgtggtc ctcatcttcc tggcctcata gctcctcctc 240 gccaagcatg tcttccccgt tgcaaagagc tgtgggagat accaagaggg ccttgtctgc 300 atcttctagt tcctctgcca gtctaccctt tgatgacagg gactcaaacc atacctcaga 360 ggggaatggc gactctttgt tagctgatga agacactgac tttgaagaca gcttgaatcg 420 caatgtgaag aagagagcag caaaacgacc accgaaaaca acaccggtgg caaaacatcc 480 aaagaaaggg tcccgagtgg tacatcgtca tagccggaaa cagtcagagc caccagccaa 540 tgatcttttc aatgctgtga aagccgccaa aagtgacatg cagtctttgg tagatgagtg 600 gctggatagc tacaagcaag accaggatgc aggatttctg gagcttgtta actttttcat 660 ccaatcttgc ggatgtaaag gcattgtgac ccctgagatg ttcaagaaga tgtccaactc 720 agagatcatc cagcacctaa cagagcagtt taatgaggac tcgggggact accctctcat 780 agctccaggt ccatcctgga agaagttcca gggcagcttc tgtgaatttg tgaggacatt 840 ggtctgtcag tgccagtaca gcctcctcta tgatggcttc cctatggacg acctcatctc 900 cctgctcact ggcctctcag actcacaagt ccgcgccttc cgtcacacta gcaccctggc 960 tgctatgaaa ctgatgacct ccctggtaaa agttgccctc caactgagtg tgcaccaaga 1020 taacaatcag cgtcagtatg aggctgaaag aaacaagggg ccagggcaga gggcacctga 1080 gcggctggag agcctgttgg agaaacgcaa agagctccaa gagcatcaag aggagattga 1140 ggggatgatg aatgccctct tcaggggtgt ctttgttcat cggtacaggg atgtccttcc 1200 tgagatccgt gctatctgca ttgaggaaat tgggtgttgg atgcaaagct acagcacgtc 1260 tttcctcacc gacagctatt taaaatatat tggttggact ctgcatgata agcaccgaga 1320 agtccgcgtg aagtgcgtga aggctctgaa agggctgtac ggtaaccggg acctgaccgc 1380 acgcctggag ctcttcacca gccgcttcaa ggaccggatg gtttccatga tcatggacag 1440 agagtacagt gtggcagtgg aggccgtcag attactgata cttatactta agaacatgga 1500 agggttgctg acggacgcgg attgtgagag cgtctacccc gttgtgtatc cttctaatcg 1560 aggcctggct tctgccgcag gcgaatttct gtactggaaa cttttctacc ctgagtgcga 1620 gataagaacg atgggtggaa gagagcaacg ccagagccca ggcgcccaga ggactttctt 1680 ccagcttctg ctgtccttct ttgtggagag cgagctccat gaccacgctg cttacttagt 1740 agacagtctg tgggactgtg caggggctcg gctgaaggac tgggagggtc tgacaagcct 1800 gctgctggag aaggaccaga acctgggtga tgtgcaggag agcacactga tagaaatcct 1860 tgtgtccagt gcccggcaag cttcagaggg gcacccgcct gtgggccggg tcactgggag 1920 gaagggctta acctctaagg agcgcaagac ccaagccgat gacagggtga agttgactga 1980 gcacctcatc cccctgctgc cccagctcct ggccaagttc tcagctgatg cagagaaggt 2040 cactcccctg ctccagcttc tcagctgctt tgacctccac atctactgca ctgggcgctt 2100 ggagaagcac ctggagctgt tcctgcagca actccaggag gtggtggtga agcatgcaga 2160 gccagcggtg cttgaggctg gggcgcatgc cctctacctg ctctgtaatc ccgaattcac 2220 tttcttcagc cgggcggact ttgcccgcag ccagctagta gatttgctga ctgaccgctt 2280 ccagcaggag cttgaagagc tgttacagtc gtccttccta gatgaggatg aggtatataa 2340 tctggcagcc actctgaaac gcctctctgc cttctacaac actcatgacc tgactcgctg 2400 ggagctctat gagccatgtt gccaactcct gcagaaggct gtggacacag gagaggttcc 2460 tcaccaggtt atcctgccag ccttgactct tgtctatttt tccattctct ggacactaac 2520 ccacatttct aaatcagatg cttcccagaa gcagctgtcg agtttgaggg acagaatggt 2580 ggccttctgt gaactctgcc agagttgcct ctcagatgtg gatactgaga tccaggagca 2640 ggcttttgtc ttattaagtg atctacttct catctttagc cctcagatga tagttggggg 2700 ccgtgatttc cttaggccac ttgtcttttt tcctgaagct actctccagt ctgagctagc 2760 cagcttcctc atggaccacg tcttcatcca gccgggagac ctgggcagtg gtgattccca 2820 ggaggatcat ttacagatag agcggctaca ccagcggcgc cgcctcctag ccgggttctg 2880 caagctgttg ctttatgggg tgctggagat ggatgcagcc tcagatgttt tcaaacacta 2940 caacaagttc tacaatgact atggtgacat tatcaaggaa acattaacta gagcaaggca 3000 gattgaccga agtcattgtt cccgaatcct gctgctgagc ctnaagcagc tgtacacaga 3060 actgctgcag gagcatgggc cccagggcct gaatgagctt cctgccttca tcgagatgag 3120 ggacctggcc cggaggtttg ccttgagttt tggaccccag cagctgcaga accgtgacct 3180 cgtggtcatg ctacacaagg aaggcatcca gttctccttg tctgagcttc ctccagctgg 3240 ctcctccaat cagcctccaa atctggcatt cctggagctc ctttcagagt tttccccccg 3300 actcttccat caggacaagc agcttttgct gtcctatcta gaaaagtgcc tgcagcatgt 3360 ctcccaggca cctggccatc cctggggccc agtcaccacc tactgccact ccctcagccc 3420 tgtggagaac acagcagaga ccagccctca ggtcctcccc agctccaaga ggaagcgcgt 3480 tgaagggcct gccaagccta acagagagga cgtctcctcg tcccaggaag aaagtctgca 3540 gctgaacagc atcccgccca cgcccaccct cacctccaca gctgtgaaga gcaggcagcc 3600 cctgtggggg ttgaaagaga tggaggaaga agatggctca gagttggatt ttgcccaggg 3660 gcagcccgtc gcaggcaccg agaggtcaag gttcttgggt ccacaatatt tccagactcc 3720 acacaaccct tcaggtcctg gcctgggcaa ccagctgatg cgactcagcc ttatggaaga 3780 ggacgaggaa gaagagttag aaatccagga tgagtcaaat gaagaacggc aggatacaga 3840 catgcaagca agtagctact cttccaccag tgagcgcggg ctggacctct tagattctac 3900 agagctggat attgaggatt tctgacagga ctctgggccc ctccccagct ccactcccta 3960 cctcaagaat gtgaccattt ggaaaaggca aagagaaaag gagcaaaatg aagcattccc 4020 ccaggcttca gccctgggct ctgaggggaa agagttgggc attgtttttc taacctaacc 4080 tttccctctg gggtagagaa gccgagagac cctgtcctcc ctaatgcact gtggcccagt 4140 ccccttgcct ttttcctgtt ctgtttggag tggagaaggg cagcacctct gtgtttaatg 4200 gaaatagccc atagtctcct ggatttttgg aacatctttc tcagcctatt ttgtgtccta 4260 atgattcgct caataaacat gtttgaatcc 4290 <210> 245 <211> 4290 <212> DNA <213> Homo sapiens <220> <221> misc_feature <222> (3043)..(3043) <223> "n" means any of A, T, G, and C. <400> 245 ccgggccgcc cgcgtgccca agcccacgtg agagggcagg acgcctgaga gcttgaggcc 60 acacgaggct gtggagcggc gtgactcaaa cgtggcgcgc atcagctcgc acacttccaa 120 acctcgcgat agctactggc cctgggcgag ccgttgggat tgcgcttgcg cacagcgtgt 180 cttctggatc gccataccta ccctgtggtc ctcatcttcc tggcctcata gctcctcctc 240 gccaagcatg tcttccccgt tgcaaagagc tgtgggagat accaagaggg ccttgtctgc 300 atcttctagt tcctctgcca gtctaccctt tgatgacagg gactcaaacc atacctcaga 360 ggggaatggc gactctttgt tagctgatga agacactgac tttgaagaca gcttgaatcg 420 caatgtgaag aagagagcag caaaacgacc accgaaaaca acaccggtgg caaaacatcc 480 aaagaaaggg tcccgagtgg tacatcgtca tagccggaaa cagtcagagc caccagccaa 540 tgatcttttc aatgctgtga aagccgccaa aagtgacatg cagtctttgg tagatgagtg 600 gctggatagc tacaagcaag accaggatgc aggatttctg gagcttgtta actttttcat 660 ccaatcttgc ggatgtaaag gcattgtgac ccctgagatg ttcaagaaga tgtccaactc 720 agagatcatc cagcacctaa cagagcagtt taatgaggac tcgggggact accctctcat 780 agctccaggt ccatcctgga agaagttcca gggcagcttc tgtgaatttg tgaggacatt 840 ggtctgtcag tgccagtaca gcctcctcta tgatggcttc cctatggacg acctcatctc 900 cctgctcact ggcctctcag actcacaagt ccgcgccttc cgtcacacta gcaccctggc 960 tgctatgaaa ctgatgacct ccctggtaaa agttgccctc caactgagtg tgcaccaaga 1020 taacaatcag cgtcagtatg aggctgaaag aaacaagggg ccagggcaga gggcacctga 1080 gcggctggag agcctgttgg agaaacgcaa agagctccaa gagcatcaag aggagattga 1140 ggggatgatg aatgccctct tcaggggtgt ctttgttcat cggtacaggg atgtccttcc 1200 tgagatccgt gctatctgca ttgaggaaat tgggtgttgg atgcaaagct acagcacgtc 1260 tttcctcacc gacagctatt taaaatatat tggttggact ctgcatgata agcaccgaga 1320 agtccgcgtg aagtgcgtga aggctctgaa agggctgtac ggtaaccggg acctgaccgc 1380 acgcctggag ctcttcacca gccgcttcaa ggaccggatg gtttccatga tcatggacag 1440 agagtacagt gtggcagtgg aggccgtcag attactgata cttatactta agaacatgga 1500 agggttgctg acggacgcgg attgtgagag cgtctacccc gttgtgtatc cttctaatcg 1560 aggcctggct tctgccgcag gcgaatttct gtactggaaa cttttctacc ctgagtgcga 1620 gataagaacg atgggtggaa gagagcaacg ccagagccca ggcgcccaga ggactttctt 1680 ccagcttctg ctgtccttct ttgtggagag cgagctccat gaccacgctg cttacttagt 1740 agacagtctg tgggactgtg caggggctcg gctgaaggac tgggagggtc tgacaagcct 1800 gctgctggag aaggaccaga acctgggtga tgtgcaggag agcacactga tagaaatcct 1860 tgtgtccagt gcccggcaag cttcagaggg gcacccgcct gtgggccggg tcactgggag 1920 gaagggctta acctctaagg agcgcaagac ccaagccgat gacagggtga agttgactga 1980 gcacctcatc cccctgctgc cccagctcct ggccaagttc tcagctgatg cagagaaggt 2040 cactcccctg ctccagcttc tcagctgctt tgacctccac atctactgca ctgggcgctt 2100 ggagaagcac ctggagctgt tcctgcagca actccaggag gtggtggtga agcatgcaga 2160 gccagcggtg cttgaggctg gggcgcatgc cctctacctg ctctgtaatc ccgaattcac 2220 tttcttcagc cgggcggact ttgcccgcag ccagctagta gatttgctga ctgaccgctt 2280 ccagcaggag cttgaagagc tgttacagtc gtccttccta gatgaggatg aggtatataa 2340 tctggcagcc actctgaaac gcctctctgc cttctacaac actcatgacc tgactcgctg 2400 ggagctctat gagccatgtt gccaactcct gcagaaggct gtggacacag gagaggttcc 2460 tcaccaggtt atcctgccag ccttgactct tgtctatttt tccattctct ggacactaac 2520 ccacatttct aaatcagatg cttcccagaa gcagctgtcg agtttgaggg acagaatggt 2580 ggccttctgt gaactctgcc agagttgcct ctcagatgtg gatactgaga tccaggagca 2640 ggcttttgtc ttattaagtg atctacttct catctttagc cctcagatga tagttggggg 2700 ccgtgatttc cttaggccac ttgtcttttt tcctgaagct actctccagt ctgagctagc 2760 cagcttcctc atggaccacg tcttcatcca gccgggagac ctgggcagtg gtgattccca 2820 ggaggatcat ttacagatag agcggctaca ccagcggcgc cgcctcctag ccgggttctg 2880 caagctgttg ctttatgggg tgctggagat ggatgcagcc tcagatgttt tcaaacacta 2940 caacaagttc tacaatgact atggtgacat tatcaaggaa acattaacta gagcaaggca 3000 gattgaccga agtcattgtt cccgaatcct gctgctgagc ctnaagcagc tgtacacaga 3060 actgctgcag gagcatgggc cccagggcct gaatgagctt cctgccttca tcgagatgag 3120 ggacctggcc cggaggtttg ccttgagttt tggaccccag cagctgcaga accgtgacct 3180 cgtggtcatg ctacacaagg aaggcatcca gttctccttg tctgagcttc ctccagctgg 3240 ctcctccaat cagcctccaa atctggcatt cctggagctc ctttcagagt tttccccccg 3300 actcttccat caggacaagc agcttttgct gtcctatcta gaaaagtgcc tgcagcatgt 3360 ctcccaggca cctggccatc cctggggccc agtcaccacc tactgccact ccctcagccc 3420 tgtggagaac acagcagaga ccagccctca ggtcctcccc agctccaaga ggaagcgcgt 3480 tgaagggcct gccaagccta acagagagga cgtctcctcg tcccaggaag aaagtctgca 3540 gctgaacagc atcccgccca cgcccaccct cacctccaca gctgtgaaga gcaggcagcc 3600 cctgtggggg ttgaaagaga tggaggaaga agatggctca gagttggatt ttgcccaggg 3660 gcagcccgtc gcaggcaccg agaggtcaag gttcttgggt ccacaatatt tccagactcc 3720 acacaaccct tcaggtcctg gcctgggcaa ccagctgatg cgactcagcc ttatggaaga 3780 ggacgaggaa gaagagttag aaatccagga tgagtcaaat gaagaacggc aggatacaga 3840 catgcaagca agtagctact cttccaccag tgagcgcggg ctggacctct tagattctac 3900 agagctggat attgaggatt tctgacagga ctctgggccc ctccccagct ccactcccta 3960 cctcaagaat gtgaccattt ggaaaaggca aagagaaaag gagcaaaatg aagcattccc 4020 ccaggcttca gccctgggct ctgaggggaa agagttgggc attgtttttc taacctaacc 4080 tttccctctg gggtagagaa gccgagagac cctgtcctcc ctaatgcact gtggcccagt 4140 ccccttgcct ttttcctgtt ctgtttggag tggagaaggg cagcacctct gtgtttaatg 4200 gaaatagccc atagtctcct ggatttttgg aacatctttc tcagcctatt ttgtgtccta 4260 atgattcgct caataaacat gtttgaatcc 4290 <210> 246 <211> 4207 <212> DNA <213> Homo sapiens <400> 246 tctggaatct ttcgcccccg gaagggcagc ggcgggcgcc tgtgtggaag gtggggtggc 60 cagagacacc cgagggacct gagctggatc gccataccta ccctgtggtc ctcatcttcc 120 tggcctcata gctcctcctc tccaagcatg tcttccccgt tgcaaagagc tgtgggagat 180 accaagaggg ccttgtctgc atcttctagt tcctctgcca gtctaccctt tgatgacagg 240 gactcaaacc atacctcaga ggggaatggc gactctttgt tagctgatga agacactgac 300 tttgaagaca gcttgaatcg caatgtgaag aagagagcag caaaacgacc accgaaaaca 360 acaccggtgg caaaacatcc aaagaaaggg tcccgagtgg tacatcgtca tagccggaaa 420 cagtcagagc caccagccaa tgatcttttc aatgctgtga aagccgccaa aagtgacatg 480 cagtctttgg tagatgagtg gctggatagc tacaagcaag accaggatgc aggatttctg 540 gagcttgtta actttttcat ccaatcttgc ggatgtaaag gcattgtgac ccctgagatg 600 ttcaagaaga tgtccaactc agagatcatc cagcacctaa cagagcagtt taatgaggac 660 tcgggggact accctctcat agctccaggt ccatcctgga agaagttcca gggcagcttc 720 tgtgaatttg tgaggacatt ggtctgtcag tgccagtaca gcctcctcta tgatggcttc 780 cctatggacg acctcatctc cctgctcact ggcctctcag actcacaagt ccgcgccttc 840 cgtcacacta gcaccctggc tgctatgaaa ctgatgacct ccctggtaaa agttgccctc 900 caactgagtg tgcaccaaga taacaatcag cgtcagtatg aggctgaaag aaacaagggg 960 ccagggcaga gggcacctga gcggctggag agcctgttgg agaaacgcaa agagctccaa 1020 gagcatcaag aggagattga ggggatgatg aatgccctct tcaggggtgt ctttgttcat 1080 cggtacaggg atgtccttcc tgagatccgt gctatctgca ttgaggaaat tgggtgttgg 1140 atgcaaagct acagcacgtc tttcctcacc gacagctatt taaaatatat tggttggact 1200 ctgcatgata agcaccgaga agtccgcctg aagtgtgtga aggccctgaa agggctgtac 1260 ggtaaccggg acctgaccac acgcctggag ctcttcacca gccgcttcaa ggaccggatg 1320 gtttccatgg tcatggacag agagtatgat gtggcagtgg aggctgtcag attactgata 1380 cttatcctta agaacatgga aggggtgctg acggacgcgg attgtgagag cgtctaccca 1440 gttgtgtatg cctctcatcg aggcctggcc tctgccgcag gcgaatttct gtactggaaa 1500 ctcttctacc ctgagtgcga gataagaatg atgggtggaa gagagcaacg ccagagccca 1560 ggcgcccaga ggactttctt ccagcttctg ctgtccttct ttgtggagag cgagctccat 1620 gaccacgctg cttacttagt agacagtctg tgggactgtg caggggctcg gctgaaggac 1680 tgggagggtc tgacaagcct gctgctggag aaggaccaga acctgggtga tgtgcaggag 1740 agcacactga tagaaatcct tgtgtccagt gcccggcaag cttcagaggg gcacccgcct 1800 gtgggccggg tcactgggag gaagggctta acctctaagg agcgcaagac ccaagccgat 1860 gacagggtga agttgactga gcacctcatc cccctgctgc cccagctcct ggccaagttc 1920 tcagctgatg cagagaaggt cactcccctg ctccagcttc tcagctgctt tgacctccac 1980 atctactgca ctgggcgctt ggaagcacct ggagctgttc ctgcagcaac tccaggaggt 2040 ggtggtgaag catgcagagc cagcggtgct tgaggctggg gcgcatgccc tctacctgct 2100 ctgtaatccc gaattcactt tcttcagccg ggcggacttt gcccgcagcc agctagtaga 2160 tttgctgact gaccgcttcc agcaggagct tgaagagctg ttacagtcgt ccttcctaga 2220 tgaggatgag gtatataatc tggcagccac tctgaaacgc ctctctgcct tctacaacac 2280 tcatgacctg actcgctggg agctctatga gccatgttgc caactcctgc agaaggctgt 2340 ggacacagga gaggttcctc accaggttat cctgccagcc ttgactcttg tctatttttc 2400 cattctctgg acactaaccc acatttctaa atcagatgct tcccagaagc agctgtcgag 2460 tttgagggac agaatggtgg ccttctgtga actctgccag agttgcctct cagatgtgga 2520 tactgagatc caggagcagg cttttgtctt attaagtgat ctacttctca tctttagccc 2580 tcagatgatt gttgggggcc gtgatttcct taggccactt gtcttttttc ctgaagctac 2640 tctccagtct gagctagcca gcttcctcat ggaccacgtc ttcatccagc cgggagacct 2700 gggcagtggt gattcccagg aggatcattt acagatagag cggctacacc agcggcgccg 2760 cctcctagcc gggttctgca agctgttgct ttatggggtg ctggagatgg atgcagcctc 2820 agatgttttc aaacactaca acaagttcta caatgactat ggtgacatta tcaaggaaac 2880 attaactaga gcaaggcaga ttgaccgaag tcattgttcc cgaatcctgc tgctgagcct 2940 caagcagctg tacacagaac tgctgcagga gcatgggccc cagggcctga atgagcttcc 3000 tgccttcatc gagatgaggg acctggcccg gaggtttgcc ttgagttttg gaccccagca 3060 gctgcagaac cgtgacctcg tggtcatgct acacaaggaa ggcatccagt tctccttgtc 3120 tgagcttcct ccagctggct cctccaatca gcctccaaat ctggcattcc tggagctcct 3180 ttcagagttt tccccccgac tcttccatca ggacaagcag cttttactgt cctatctaga 3240 aaagtgcctg cagcatgtct cccaggcacc tggccatccc tggggcccag tcaccaccta 3300 ctgccactcc ctcagccctg tggagaacac agcagagacc agccctcagg tcctccccag 3360 ctccaagagg aggcgcgttg aagggcctgc caagcctaac agagaggacg tctcctcgtc 3420 ccaggaagaa agtctgcagc tgaacagcat cccgcccacg cccaccctca cctccacagc 3480 tgtgaagagc aggcagcccc tgtgggggtt gaaagagatg gaggaagaag atggctcaga 3540 gttggatttt gcccagggca gtcagcccgt cgcaggcacc gagaggtcaa ggttcttggg 3600 tccacaatat ttccagactc cacacaaccc ttcaggtcct ggcctgggca accagctgat 3660 gcgactcagc cttatggaag aggacgagga agaagagtta gaaatccagg atgagtcaaa 3720 tgaagaacgg caggatacag acatgcaagc aagtagctac tcttccacca gtgagcgcgg 3780 gctggacctc ttagattcta cagagctgga tattgaggat ttctgacagg actctgggcc 3840 cctccccagc tccactccct acctcaagaa tgtgaccatt tggaaaaggc aaagagaaaa 3900 ggagcaaaat gaagcattcc cccaggcttc agccctgggc tctgagggga aagagttggg 3960 cattgttttt ctaacctaac ctttccctct ggggtagaga agccgagaga ccctgtcctc 4020 ccttatgcac tgtggcccag tccccttgcc tttttcctgt tctgtttgga gtggagaagg 4080 gcagcacctc tgtgtttaat ggaaatagcc catagtctcc tggatttttg gaacatcttt 4140 ctcagcctat tttgtgtcct aatgattcgc tcaataaaca tgtttgaatc caaaaaaaaa 4200 aaaaaaa 4207 <210> 247 <211> 4201 <212> DNA <213> Homo sapiens <400> 247 agcggctttc gcccccggaa gggcagcggc gggcgcctgt gtggaaggtg gggtggccag 60 agacacccga gggacctgag ctggatcgcc atacctaccc tgtggtcctc atcttcctgg 120 cctcatagct cctcctctcc aagcatgtct tccccgttgc aaagagctgt gggagatacc 180 aagagggcct tgtctgcatc ttctagttcc tctgccagtc taccctttga tgacagggac 240 tcaaaccata cctcagaggg gaatggcgac tctttgttag ctgatgaaga cactgacttt 300 gaagacagct tgaatcgcaa tgtgaagaag agagcagcaa aacgaccacc gaaaacaaca 360 ccggtggcaa aacatccaaa gaaagggtcc cgagtggtac atcgtcatag ccggaaacag 420 tcagagccac cagccaatga tcttttcaat gctgtgaaag ccgccaaaag tgacatgcag 480 tctttggtag atgagtggct ggatagctac aagcaagacc aggatgcagg atttctggag 540 cttgttaact ttttcatcca atcttgcgga tgtaaaggca ttgtgacccc tgagatgttc 600 aagaagatgt ccaactcaga gatcatccag cacctaacag agcagtttaa tgaggactcg 660 ggggactaca ctctcatagc tccaggtcca tcctggaaga agttccaggg cagcttctgt 720 gaatttgtga ggacattggt ctgtcagtgc cagtacagcc tcctctatga tggcttccct 780 atggacgacc tcatctccct gctcactggc ctctcagact cacaagtccg cgccttccgt 840 cacactagca ccctggctgc tgaaactgat gacctccctg gtaaaagttg ccctccaact 900 gagtgtgcac caagataaca atcagcgtca gtatgaggct gaaagaaaca aggggccagg 960 gcagagggca cctgagcggc tggagagcct gttggagaaa cgcaaagagc tccaagagca 1020 tcaagaggag attgagggga tgatgaatgc cctcttcagg ggtgtctttg ttcatcggta 1080 cagggatgtc cttcctgaga tccgtgctat ctgcattgag gaaattgggt gttggatgca 1140 aagctacagc acgtctttcc tcaccgacag ctatttaaaa tatattggtt ggactctgca 1200 tgataagcac cgagaagtcc gcctgaagtg tgtgaaggcc ctgaaagggc tgtacggtaa 1260 ccgggacctg accacacgcc tggagctctt caccagccgc ttcaaggacc ggatggtttc 1320 catggtcatg gacagagagt atgatgtggc agtggaggct gtcagattac tgatacttat 1380 ccttaagaac atggaagggg tgctgacgga cgcggattgt gagagcgtct acccagttgt 1440 gtatgcctct catcgaggcc tggcctctgc cgcaggcgaa tttctgtact ggaaactctt 1500 ctaccctgag tgcgagataa gaatgatggg tggaagagag caacgccaga gcccaggcgc 1560 ccagaggact ttcttccagc ttctgctgtc cttctttgtg gagagcgagc tccatgacca 1620 cgctgcttac ttagtagaca gtctgtggga ctgtgcaggg gctcggctga aggactggga 1680 gggtctgaca agcctgctgc tggagaagga ccagaacctg ggtgatgtgc aggagagcac 1740 actgatagaa atccttgtgt ccagtgcccg gcaagcttca gaggggcacc cgcctgtggg 1800 ccgggtcact gggaggaagg gcttaacctc taaggagcgc aagacccaag ccgatgacag 1860 ggtgaagttg actgagcacc tcatccccct gctgccccag ctcctggcca agttctcagc 1920 tgatgcagag aaggtcactc ccctgctcca gcttctcagc tgctttgacc tccacatcta 1980 ctgcactggg cgcttggaga agcacctgga gctgttcctg cagcaactcc aggaggtggt 2040 ggtgaagcat gcagagccag cggtgcttga ggctggggcg catgccctct acctgctctg 2100 taatcccgaa ttcactttct tcagccgggc ggactttgcc cgcagccagc tagtagattt 2160 gctgactgac cgcttccagc aggagcttga agagctgtta cagtcgtcct tcctagatga 2220 ggatgaggta tataatctgg cagccactct gaaacgcctc tctgccttct acaacactca 2280 tgacctgact cgctgggagc tctatgagcc atgttgccaa ctcctgcaga aggctgtgga 2340 cacaggagag gttcctcacc aggttatcct gccagccttg actcttgtct atttttccat 2400 tctctggaca ctaacccaca tttctaaatc agatgcttcc cagaagcagc tgtcgagttt 2460 gagggacaga atggtggcct tctgtgaact ctgccagagt tgcctctcag atgtggatac 2520 tgagatccag gagcaggctt ttgtcttatt aagtgatcta cttctcatct ttagccctca 2580 gatgattgtt gggggccgtg atttccttag gccacttgtc ttttttcctg aagctactct 2640 ccagtctgag ctagccagct tcctcatgga ccacgtcttc atccagccgg gagacctggg 2700 cagtggtgat tcccaggagg atcatttaca gatagagcgg ctacaccagc ggcgccgcct 2760 cctagccggg ttctgcaagc tgttgcttta tggggtgctg gagatggatg cagcctcaga 2820 tgttttcaaa cactacaaca agttctacaa tgactatggt gacattatca aggaaacatt 2880 aactagagca aggcagattg accgaagtca ttgttcccga atcctgctgc tgagcctcaa 2940 gcagctgtac acagaactgc tgcaggagca tgggccccag ggcctgaatg agcttcctgc 3000 cttcatcgag atgagggacc tggcccggag gtttgccttg agttttggac cccagcagct 3060 gcagaaccgt gacctcgtgg tcatgctaca caaggaaggc atccagttct ccttgtctga 3120 gcttcctcca gctggctcct ccaatcagcc tccaaatctg gcattcctgg agctcctttc 3180 agagttttcc ccccgactct tccatcagga caagcagctt ttactgtcct atctagaaaa 3240 gtgcctgcag catgtctccc aggcacctgg ccatccctgg ggcccagtca ccacctactg 3300 ccactccctc agccctgtgg agaacacagc agagaccagc cctcaggtcc tccccagctc 3360 caagaggagg cgcgttgaag ggcctgccaa gcctaacaga gaggacgtct cctcgtccca 3420 ggaagaaagt ctgcagctga acagcatccc gcccacgccc accctcacct ccacagctgt 3480 gaagagcagg cagcccctgt gggggttgaa agagatggag gaagaagatg gctcagagtt 3540 ggattttgcc cagggtcagc ccgtcgcagg caccgagagg tcaaggttct tgggtccaca 3600 atatttccag actccacaca acccttcagg tcctggcctg ggcaaccagc tgatgcgact 3660 cagccttatg gaagaggacg gggaagaaga gttagaaatc caggatgagt caaatgaaga 3720 acggcaggat acagacatgc aagcaagtag ctactcttcc accagtgagc gcgggctgga 3780 cctcttagat tctacagagc tggatattga ggatttctga caggactctg ggcccctccc 3840 cagctccact ccctacctca agaatgtgac catttggaaa aggcaaagag aaaaggagca 3900 aaatgaagca ttcccccagg cttcagccct gggctctgag gggaaagagt tgggcattgt 3960 ttttctaacc taacctttcc ctctggggta gagaagccga gagaccctgt cctcccttat 4020 gcactgtggc ccagtcccct tgcctttttc ctgttctgtt tggagtggag aagggcagca 4080 cctctgtgtt taatggaaat agcccatagt ctcctggatt tttggaacat ctttctcagc 4140 ctattttgtg tcctaatgat tcgctcaata aacatgtttg aatccaaaaa aaaaaaaaaa 4200 a 4201 <210> 248 <211> 8265 <212> DNA <213> Homo sapiens <400> 248 gcctccacac ggctccgtcg ggcgccgcgc tcttccggca gcggtacgtt tggagacgcc 60 gggaacccgc gttggcgtgg ttgactagtg cctcgcagcc tcagcatggg ggaacatggc 120 ctggagctgg cttccatgat ccccgccctg cgggagctgg gcagtgccac accagaggaa 180 tataatacag ttgtacagaa gccaagacaa attctgtgtc aattcattga ccggatactt 240 acagatgtaa atgttgttgc tgtagaactt gtaaagaaaa ctgactctca gccaacctcc 300 gtgatgttgc ttgatttcat ccagcatatc atgaaatcct ccccacttat gtttgtaaat 360 gtgagtggaa gccatgagcg caaaggcagt tgtattgaat tcagtaattg gatcataacg 420 agacttctgc ggattgcagc aactccctcc tgtcatttgt tacacaagaa aatctgtgaa 480 gtcatctgtt cattattatt tctttttaaa agcaagagtc ctgctatttt tggggtactc 540 acaaaagaat tattacaact ttttgaagac ttggtttacc tccatagaag aaatgtgatg 600 ggtcatgctg tggaatggcc agtggtcatg agccgatttt taagtcaatt agatgaacac 660 atgggatatt tacaatcagc tcctttgcag ttgatgagta tgcaaaattt agaatttatt 720 gaagtcactt tattaatggt tcttactcgt attattgcaa ttgtgttttt tagaaggcaa 780 gaactcttac tttggcagat aggttgtgtt ctgctagagt atggtagtcc aaaaattaaa 840 tccctagcaa ttagcttttt aacagaactt tttcagcttg gaggactacc agcacaacca 900 gctagcactt ttttcagctc atttttggaa ttattaaaac accttgtaga aatggatact 960 gaccaattga aactctatga agagccatta tcaaagctga taaagacact atttcccttt 1020 gaagcagaag cttatagaaa tattgaacct gtctatttaa atatgctgct ggaaaaactc 1080 tgtgtcatgt ttgaagacgg tgtgctcatg cggcttaagt ctgatttgct aaaagcagct 1140 ttgtgccatt tactgcagta tttccttaaa tttgtgccag ctgggtatga atctgcttta 1200 caagtcagga aggtctatgt gagaaatatt tgtaaagctc ttttggatgt gcttggaatt 1260 gaggtagatg cagagtactt gttgggccca ctttatgcag ctttgaaaat ggaaagtatg 1320 gaaatcattg aggagattca atgccaaact caacaggaaa acctcagcag taatagtgat 1380 ggaatatcac ccaaaaggcg tcgtctcagc tcgtctctaa acccttctaa aagagcacca 1440 aaacagactg aggaaattaa acatgtggac atgaaccaaa agagcatatt atggagtgca 1500 ctgaaacaga aagctgaatc ccttcagatt tcccttgaat acagtggcct aaagaatcct 1560 gttattgaga tgttagaagg aattgctgtt gtcttacaac tgactgctct gtgtactgtt 1620 cattgttctc atcaaaacat gaactgccgt actttcaagg actgtcaaca taaatccaag 1680 aagaaacctt ctgtagtgat aacttggatg tcattggatt tttacacaaa agtgcttaag 1740 agctgtagaa gtttgttaga atctgttcag aaactggacc tggaggcaac cattgataag 1800 gtggtgaaaa tttatgatgc tttgatttat atgcaagtaa acagttcatt tgaagatcat 1860 atcctggaag atttatgtgg tatgctctca cttccatgga tttattccca ttctgatgat 1920 ggctgtttaa agttgaccac atttgccgct aatcttctaa cattaagctg taggatttca 1980 gatagctatt caccacaggc acaatcacga tgtgtgtttc ttctgactct gtttccaaga 2040 agaatattcc ttgagtggag aacagcagtt tacaactggg ccctgcagag ctcccatgaa 2100 gtaatccggg ctagttgtgt tagtggattt tttatcttat tgcagcagca gaattcttgt 2160 aacagagttc ccaagattct tatagataaa gtcaaagatg attctgacat tgtcaagaaa 2220 gaatttgctt ctatacttgg tcaacttgtc tgtactcttc acggcatgtt ttatctgaca 2280 agttctttaa cagaaccttt ctctgaacac ggacatgtgg acctcttctg taggaacttg 2340 aaagccactt ctcaacatga atgttcatct tctcaactaa aagcttctgt ctgcaagcca 2400 ttccttttcc tactgaaaaa aaaaatacct agtccagtaa aacttgcttt catagataat 2460 ctacatcatc tttgtaagca tcttgatttt agagaagatg aaacagatgt aaaagcagtt 2520 cttggaactt tattaaattt aatggaagat ccagacaaag atgttagagt ggcttttagt 2580 ggaaatatca agcacatatt ggaatccttg gactctgaag atggatttat aaaggagctt 2640 tttgtcttaa gaatgaagga agcatataca catgcccaaa tatcaagaaa taatgagctg 2700 aaggatacct tgattcttac aacaggggat attggaaggg ccgcaaaagg agatttggta 2760 ccatttgcac tcttacactt attgcattgt ttgttatcca agtcagcatc tgtctctgga 2820 gcagcataca cagaaattag agctctggtt gcagctaaaa gtgttaaact gcaaagtttt 2880 ttcagccagt ataagaaacc catctgtcag tttttggtag aatcccttca ctctagtcag 2940 atgacagcac ttccgaatac tccatgccag aatgctgacg tgcgaaaaca agatgtggct 3000 caccagagag aaatggcttt aaatacgttg tctgaaattg ccaacgtttt cgactttcct 3060 gatcttaatc gttttcttac taggacatta caagttctac tacctgatct tgctgccaaa 3120 gcaagccctg cagcttctgc tctcattcga actttaggaa aacaattaaa tgtcaatcgt 3180 agagagattt taataaacaa cttcaaatat attttttctc atttggtctg ttcttgttcc 3240 aaagatgaat tagaacgtgc ccttcattat ctgaagaatg aaacagaaat tgaactgggg 3300 agcctgttga gacaagattt ccaaggattg cataatgaat tattgctgcg tattggagaa 3360 cactatcaac aggtttttaa tggtttgtca atacttgcct catttgcatc cagtgatgat 3420 ccatatcagg gcccgagaga tatcatatca cctgaactga tggctgatta tttacaaccc 3480 aaattgttgg gcattttggc tttttttaac atgcagttac tgagctctag tgttggcatt 3540 gaagataaga aaatggcctt gaacagtttg atgtctttga tgaagttaat gggacccaaa 3600 catgtcagtt ctgtgagggt gaagatgatg accacactga gaactggcct tcgattcaag 3660 gatgattttc ctgaattgtg ttgcagagct tgggactgct ttgttcgctg cctggatcat 3720 gcttgtctgg gctcccttct cagtcatgta atagtagctt tgttacctct tatacacatc 3780 cagcctaaag aaactgcagc tatcttccac tacctcataa ttgaaaacag ggatgctgtg 3840 caagattttc ttcatgaaat atatttttta cctgatcatc cagaattaaa aaagataaaa 3900 gccgttctcc aggaatacag aaaggagacc tctgagagca ctgatcttca gacaactctt 3960 cagctctcta tgaaggccat tcaacatgaa aatgtcgatg ttcgtattca tgctcttaca 4020 agcttgaagg aaaccttgta taaaaatcag gaaaaactga taaagtatgc aacagacagt 4080 gaaacagtag aacctattat ctcacagttg gtgacagtgc ttttgaaagg ttgccaagat 4140 gcaaactctc aagctcggtt gctctgtggg gaatgtttag gggaattggg ggcgatagat 4200 ccaggtcgat tagatttctc aacaactgaa actcaaggaa aagattttac atttgtgact 4260 ggagtagaag attcaagctt tgcctatgga ttattgatgg agctaacaag agcttacctt 4320 gcgtatgctg ataatagccg agctcaagat tcagctgcct atgccattca ggagttgctt 4380 tctatttatg actgtagaga gatggagacc aacggcccag gtcaccaatt gtggaggaga 4440 tttcctgagc atgttcggga aatactagaa cctcatctaa ataccagata caagagttct 4500 cagaagtcaa ccgattggtc tggagtaaag aagccaattt acttaagtaa attgggtagt 4560 aactttgcag aatggtcagc atcttgggca ggttatctta ttacaaaggt tcgacatgat 4620 cttgccagta aaattttcac ctgctgtagc attatgatga agcatgattt caaagtgacc 4680 atctatcttc ttccacatat tctggtgtat gtcttactgg gttgtaatca agaagatcag 4740 caggaggttt atgcagaaat tatggcagtt ctaaagcatg acgatcagca taccataaat 4800 acccaagaca ttgcatctga tctgtgtcaa ctcagtacac agactgtgtt ctccatgctt 4860 gaccatctca cacagtgggc aaggcacaaa tttcaggcac tgaaagctga gaaatgtcca 4920 cacagcaaat caaacagaaa taaggtagac tcaatggtat ctactgtgga ttatgaagac 4980 tatcagagtg taacccgttt tctagacctc ataccccagg atactctggc agtagcttcc 5040 tttcgctcca aagcatacac acgagctgta atgcactttg aatcatttat tacagaaaag 5100 aagcaaaata ttcaggaaca tcttggattt ttacagaaat tgtatgctgc tatgcatgaa 5160 cctgatggag tggccggagt cagtgcaatt agaaaggcag aaccatctct aaaagaacag 5220 atccttgaac atgaaagcct tggcttgctg agggatgcca ctgcttgtta tgacagggct 5280 attcagctag aaccagacca gatcattcat tatcatggtg tagtaaagtc catgttaggt 5340 cttggtcagc tgtctactgt tatcactcag gtgaatggag tgcatgctaa caggtccgag 5400 tggacagatg aattaaacac gtacagagtg gaagcagctt ggaaattgtc acagtgggat 5460 ttggtggaaa actatttggc agcagatgga aaatctacaa catggagtgt cagactggga 5520 cagctattat tatcagccaa aaaaagagat atcacagctt tttatgactc actgaaacta 5580 gtgagagcag aacaaattgt acctctttca gctgcaagct ttgaaagagg ctcctaccaa 5640 cgaggatatg aatatattgt gagattgcac atgttatgtg agttggagca tagcatcaaa 5700 ccacttttcc agcattctcc aggtgacagt tctcaagaag attctctaaa ctgggtagct 5760 cgactagaaa tgacccagaa ttcctacaga gccaaggagc ctatcctggc tctccggagg 5820 gctttactaa gcctcaacaa aagaccagat tacaatgaaa tggttggaga atgctggctg 5880 cagagtgcca gggtagctag aaaggctggt caccaccaga cagcctacaa tgctctcctt 5940 aatgcagggg aatcacgact cgctgaactg tacgtggaaa gggcaaagtg gctctggtcc 6000 aagggtgatg ttcaccaggc actaattgtt cttcaaaaag gtgttgaatt atgttttcct 6060 gaaaatgaaa ccccacctga gggtaagaac atgttaatcc atggtcgagc tatgctacta 6120 gtgggccgat ttatggaaga aacagctaac tttgaaagca atgcaattat gaaaaaatat 6180 aaggatgtga ccgcgtgcct gccagaatgg gaggatgggc atttttacct tgccaagtac 6240 tatgacaaat tgatgcccat ggtcacagac aacaaaatgg aaaagcaagg tgatctcatc 6300 cggtatatag ttcttcattt tggcagatct ctacaatatg gaaatcagtt catatatcag 6360 tcaatgccac gaatgttaac tctatggctt gattatggta caaaggcata tgaatgggaa 6420 aaagctggcc gctccgatcg tgtacaaatg aggaatgatt tgggtaaaat aaacaaggtt 6480 atcacagagc atacaaacta tttagctcca tatcaatttt tgactgcttt ttcacaattg 6540 atctctcgaa tttgtcattc tcacgatgaa gtttttgttg tcttgatgga aataatagcc 6600 aaagtatttc tagcctatcc tcaacaagca atgtggatga tgacagctgt gtcaaagtca 6660 tcttatccca tgcgtgtgaa cagatgcaag gaaatcctca ataaagctat tcatatgaaa 6720 aaatccttag agaagtttgt tggagatgca actcgcctaa cagataagct tctagaattg 6780 tgcaataaac cggttgatgg aagtagttcc acattaagca tgagcactca ttttaaaatg 6840 cttaaaaagc tggtagaaga agcaacattt agtgaaatcc tcattcctct acaatcagtc 6900 atgataccta cacttccatc aattctgggt acccatgcta accatgctag ccatgaacca 6960 tttcctggac attgggccta tattgcaggg tttgatgata tggtggaaat tcttgcttct 7020 cttcagaaac caaagaagat ttctttaaaa ggctcagatg gaaagttcta catcatgatg 7080 tgtaagccaa aagatgacct gagaaaggat tgtagactaa tggaattcaa ttccttgatt 7140 aataagtgct taagaaaaga tgcagagtct cgtagaagag aacttcatat tcgaacatat 7200 gcagttattc cactaaatga tgaatgtggg attattgaat gggtgaacaa cactgctggt 7260 ttgagaccta ttctgaccaa actatataaa gaaaagggag tgtatatgac aggaaaagaa 7320 cttcgccagt gtatgctacc aaagtcagca gctttatctg aaaaactcaa agtattccga 7380 gaatttctcc tgcccaggca tcctcctatt tttcatgagt ggtttctgag aacattccct 7440 gatcctacat catggtacag tagtagatca gcttactgcc gttccactgc agtaatgtca 7500 atggttggtt atattctggg gcttggagac cgtcatggtg aaaatattct ctttgattct 7560 ttgactggtg aatgcgtaca tgtagatttc aattgtcttt tcaataaggg agaaaccttt 7620 gaagttccag aaattgtgcc atttcgcctg actcataata tggttaatgg aatgggtcct 7680 atgggaacag agggtctttt tcgaagagca tgtgaagtta caatgaggct gatgcgtgat 7740 cagcgagagc ctttaatgag tgtcttaaag acttttctac atgatcctct tgtggaatgg 7800 agtaaaccag tgaaagggca ttccaaagcg ccactgaatg aaactggaga agttgtcaat 7860 gaaaaggcca agacccatgt tcttgacatt gagcagcgac tacaaggtgt aatcaagact 7920 cgaaatagag tgacaggact gccgttatct attgaaggac atgtgcatta ccttatacaa 7980 gaagctactg atgaaaactt actatgccag atgtatcttg gttggactcc atatatgtga 8040 aatgaaatta tgtaaaagaa tatgttaata atctaaaagt aatgcatttg gtatgaatct 8100 gtggttgtat ctgttcaatt ctaaagtaca acataaattt acgttctcag caactgttat 8160 ttctctctga tcattaatta tatgtaaaat aatatacatt cagttattaa gaaataaact 8220 gctttcttaa taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa 8265 <210> 249 <211> 8239 <212> DNA <213> Homo sapiens <400> 249 gcgctcttcc ggcagcggta cgtttggaga cgccgggaac ccgcgttggc gtggttgact 60 agtgcctcgc agcctcagca tgggggaaca tggcctggag ctggcttcca tgatccccgc 120 cctgcgggag ctgggcagtg ccacaccaga ggaatataat acagttgtac agaagccaag 180 acaaattctg tgtcaattca ttgaccggat acttacagat gtaaatgttg ttgctgtaga 240 acttgtaaag aaaactgact ctcagccaac ctccgtgatg ttgcttgatt tcatccagca 300 tatcatgaaa tcctccccac ttatgtttgt aaatgtgagt ggaagccatg agcgcaaagg 360 cagttgtatt gaattcagta attggatcat aacgagactt ctgcggattg cagcaactcc 420 ctcctgtcat ttgttacaca agaaaatctg tgaagtcatc tgttcattat tatttctttt 480 taaaagcaag agtcctgcta tttttggggt actcacaaaa gaattattac aactttttga 540 agacttggtt tacctccata gaagaaatgt gatgggtcat gctgtggaat ggccagtggt 600 catgagccga tttttaagtc aattagatga acacatggga tatttacaat cagctccttt 660 gcagttgatg agtatgcaaa atttagaatt tattgaagtc actttattaa tggttcttac 720 tcgtattatt gcaattgtgt tttttagaag gcaagaactc ttactttggc agataggttg 780 tgttctgcta gagtatggta gtccaaaaat taaatcccta gcaattagct ttttaacaga 840 actttttcag cttggaggac taccagcaca accagctagc acttttttca gctcattttt 900 ggaattatta aaacaccttg tagaaatgga tactgaccaa ttgaaactct atgaagagcc 960 attatcaaag ctgataaaga cactatttcc ctttgaagca gaagcttata gaaatattga 1020 acctgtctat ttaaatatgc tgctggaaaa actctgtgtc atgtttgaag acggtgtgct 1080 catgcggctt aagtctgatt tgctaaaagc agctttgtgc catttactgc agtatttcct 1140 taaatttgtg ccagctgggt atgaatctgc tttacaagtc aggaaggtct atgtgagaaa 1200 tatttgtaaa gctcttttgg atgtgcttgg aattgaggta gatgcagagt acttgttggg 1260 cccactttat gcagctttga aaatggaaag tatggaaatc attgaggaga ttcaatgcca 1320 aactcaacag gaaaacctca gcagtaatag tgatggaata tcacccaaaa ggcgtcgtct 1380 cagctcgtct ctaaaccctt ctaaaagagc accaaaacag actgaggaaa ttaaacatgt 1440 ggacatgaac caaaagagca tattatggag tgcactgaaa cagaaagctg aatcccttca 1500 gatttccctt gaatacagtg gcctaaagaa tcctgttatt gagatgttag aaggaattgc 1560 tgttgtctta caactgactg ctctgtgtac tgttcattgt tctcatcaaa acatgaactg 1620 ccgtactttc aaggactgtc aacataaatc caagaagaaa ccttctgtag tgataacttg 1680 gatgtcattg gatttttaca caaaagtgct taagagctgt agaagtttgt tagaatctgt 1740 tcagaaactg gacctggagg caaccattga taaggtggtg aaaatttatg atgctttgat 1800 ttatatgcaa gtaaacagtt catttgaaga tcatatcctg gaagatttat gtggtatgct 1860 ctcacttcca tggatttatt cccattctga tgatggctgt ttaaagttga ccacatttgc 1920 cgctaatctt ctaacattaa gctgtaggat ttcagatagc tattcaccac aggcacaatc 1980 acgatgtgtg tttcttctga ctctgtttcc aagaagaata ttccttgagt ggagaacagc 2040 agtttacaac tgggccctgc agagctccca tgaagtaatc cgggctagtt gtgttagtgg 2100 attttttatc ttattgcagc agcagaattc ttgtaacaga gttcccaaga ttcttataga 2160 taaagtcaaa gatgattctg acattgtcaa gaaagaattt gcttctatac ttggtcaact 2220 tgtctgtact cttcacggca tgttttatct gacaagttct ttaacagaac ctttctctga 2280 acacggacat gtggacctct tctgtaggaa cttgaaagcc acttctcaac atgaatgttc 2340 atcttctcaa ctaaaagctt ctgtctgcaa gccattcctt ttcctactga aaaaaaaaat 2400 acctagtcca gtaaaacttg ctttcataga taatctacat catctttgta agcatcttga 2460 ttttagagaa gatgaaacag atgtaaaagc agttcttgga actttattaa atttaatgga 2520 agatccagac aaagatgtta gagtggcttt tagtggaaat atcaagcaca tattggaatc 2580 cttggactct gaagatggat ttataaagga gctttttgtc ttaagaatga aggaagcata 2640 tacacatgcc caaatatcaa gaaataatga gctgaaggat accttgattc ttacaacagg 2700 ggatattgga agggccgcaa aaggagattt ggtaccattt gcactcttac acttattgca 2760 ttgtttgtta tccaagtcag catctgtctc tggagcagca tacacagaaa ttagagctct 2820 ggttgcagct aaaagtgtta aactgcaaag ttttttcagc cagtataaga aacccatctg 2880 tcagtttttg gtagaatccc ttcactctag tcagatgaca gcacttccga atactccatg 2940 ccagaatgct gacgtgcgaa aacaagatgt ggctcaccag agagaaatgg ctttaaatac 3000 gttgtctgaa attgccaacg ttttcgactt tcctgatctt aatcgttttc ttactaggac 3060 attacaagtt ctactacctg atcttgctgc caaagcaagc cctgcagctt ctgctctcat 3120 tcgaacttta ggaaaacaat taaatgtcaa tcgtagagag attttaataa acaacttcaa 3180 atatattttt tctcatttgg tctgttcttg ttccaaagat gaattagaac gtgcccttca 3240 ttatctgaag aatgaaacag aaattgaact ggggagcctg ttgagacaag atttccaagg 3300 attgcataat gaattattgc tgcgtattgg agaacactat caacaggttt ttaatggttt 3360 gtcaatactt gcctcatttg catccagtga tgatccatat cagggcccga gagatatcat 3420 atcacctgaa ctgatggctg attatttaca acccaaattg ttgggcattt tggctttttt 3480 taacatgcag ttactgagct ctagtgttgg cattgaagat aagaaaatgg ccttgaacag 3540 tttgatgtct ttgatgaagt taatgggacc caaacatgtc agttctgtga gggtgaagat 3600 gatgaccaca ctgagaactg gccttcgatt caaggatgat tttcctgaat tgtgttgcag 3660 agcttgggac tgctttgttc gctgcctgga tcatgcttgt ctgggctccc ttctcagtca 3720 tgtaatagta gctttgttac ctcttataca catccagcct aaagaaactg cagctatctt 3780 ccactacctc ataattgaaa acagggatgc tgtgcaagat tttcttcatg aaatatattt 3840 tttacctgat catccagaat taaaaaagat aaaagccgtt ctccaggaat acagaaagga 3900 gacctctgag agcactgatc ttcagacaac tcttcagctc tctatgaagg ccattcaaca 3960 tgaaaatgtc gatgttcgta ttcatgctct tacaagcttg aaggaaacct tgtataaaaa 4020 tcaggaaaaa ctgataaagt atgcaacaga cagtgaaaca gtagaaccta ttatctcaca 4080 gttggtgaca gtgcttttga aaggttgcca agatgcaaac tctcaagctc ggttgctctg 4140 tggggaatgt ttaggggaat tgggggcgat agatccaggt cgattagatt tctcaacaac 4200 tgaaactcaa ggaaaagatt ttacatttgt gactggagta gaagattcaa gctttgccta 4260 tggattattg atggagctaa caagagctta ccttgcgtat gctgataata gccgagctca 4320 agattcagct gcctatgcca ttcaggagtt gctttctatt tatgactgta gagagatgga 4380 gaccaacggc ccaggtcacc aattgtggag gagatttcct gagcatgttc gggaaatact 4440 agaacctcat ctaaatacca gatacaagag ttctcagaag tcaaccgatt ggtctggagt 4500 aaagaagcca atttacttaa gtaaattggg tagtaacttt gcagaatggt cagcatcttg 4560 ggcaggttat cttattacaa aggttcgaca tgatcttgcc agtaaaattt tcacctgctg 4620 tagcattatg atgaagcatg atttcaaagt gaccatctat cttcttccac atattctggt 4680 gtatgtctta ctgggttgta atcaagaaga tcagcaggag gtttatgcag aaattatggc 4740 agttctaaag catgacgatc agcataccat aaatacccaa gacattgcat ctgatctgtg 4800 tcaactcagt acacagactg tgttctccat gcttgaccat ctcacacagt gggcaaggca 4860 caaatttcag gcactgaaag ctgagaaatg tccacacagc aaatcaaaca gaaataaggt 4920 agactcaatg gtatctactg tggattatga agactatcag agtgtaaccc gttttctaga 4980 cctcataccc caggatactc tggcagtagc ttcctttcgc tccaaagcat acacacgagc 5040 tgtaatgcac tttgaatcat ttattacaga aaagaagcaa aatattcagg aacatcttgg 5100 atttttacag aaattgtatg ctgctatgca tgaacctgat ggagtggccg gagtcagtgc 5160 aattagaaag gcagaaccat ctctaaaaga acagatcctt gaacatgaaa gccttggctt 5220 gctgagggat gccactgctt gttatgacag ggctattcag ctagaaccag accagatcat 5280 tcattatcat ggtgtagtaa agtccatgtt aggtcttggt cagctgtcta ctgttatcac 5340 tcaggtgaat ggagtgcatg ctaacaggtc cgagtggaca gatgaattaa acacgtacag 5400 agtggaagca gcttggaaat tgtcacagtg ggatttggtg gaaaactatt tggcagcaga 5460 tggaaaatct acaacatgga gtgtcagact gggacagcta ttattatcag ccaaaaaaag 5520 agatatcaca gctttttatg actcactgaa actagtgaga gcagaacaaa ttgtacctct 5580 ttcagctgca agctttgaaa gaggctccta ccaacgagga tatgaatata ttgtgagatt 5640 gcacatgtta tgtgagttgg agcatagcat caaaccactt ttccagcatt ctccaggtga 5700 cagttctcaa gaagattctc taaactgggt agctcgacta gaaatgaccc agaattccta 5760 cagagccaag gagcctatcc tggctctccg gagggcttta ctaagcctca acaaaagacc 5820 agattacaat gaaatggttg gagaatgctg gctgcagagt gccagggtag ctagaaaggc 5880 tggtcaccac cagacagcct acaatgctct ccttaatgca ggggaatcac gactcgctga 5940 actgtacgtg gaaagggcaa agtggctctg gtccaagggt gatgttcacc aggcactaat 6000 tgttcttcaa aaaggtgttg aattatgttt tcctgaaaat gaaaccccac ctgagggtaa 6060 gaacatgtta atccatggtc gagctatgct actagtgggc cgatttatgg aagaaacagc 6120 taactttgaa agcaatgcaa ttatgaaaaa atataaggat gtgaccgcgt gcctgccaga 6180 atgggaggat gggcattttt accttgccaa gtactatgac aaattgatgc ccatggtcac 6240 agacaacaaa atggaaaagc aaggtgatct catccggtat atagttcttc attttggcag 6300 atctctacaa tatggaaatc agttcatata tcagtcaatg ccacgaatgt taactctatg 6360 gcttgattat ggtacaaagg catatgaatg ggaaaaagct ggccgctccg atcgtgtaca 6420 aatgaggaat gatttgggta aaataaacaa ggttatcaca gagcatacaa actatttagc 6480 tccatatcaa tttttgactg ctttttcaca attgatctct cgaatttgtc attctcacga 6540 tgaagttttt gttgtcttga tggaaataat agccaaagta tttctagcct atcctcaaca 6600 agcaatgtgg atgatgacag ctgtgtcaaa gtcatcttat cccatgcgtg tgaacagatg 6660 caaggaaatc ctcaataaag ctattcatat gaaaaaatcc ttagagaagt ttgttggaga 6720 tgcaactcgc ctaacagata agcttctaga attgtgcaat aaaccggttg atggaagtag 6780 ttccacatta agcatgagca ctcattttaa aatgcttaaa aagctggtag aagaagcaac 6840 atttagtgaa atcctcattc ctctacaatc agtcatgata cctacacttc catcaattct 6900 gggtacccat gctaaccatg ctagccatga accatttcct ggacattggg cctatattgc 6960 agggtttgat gatatggtgg aaattcttgc ttctcttcag aaaccaaaga agatttcttt 7020 aaaaggctca gatggaaagt tctacatcat gatgtgtaag ccaaaagatg acctgagaaa 7080 ggattgtaga ctaatggaat tcaattcctt gattaataag tgcttaagaa aagatgcaga 7140 gtctcgtaga agagaacttc atattcgaac atatgcagtt attccactaa atgatgaatg 7200 tgggattatt gaatgggtga acaacactgc tggtttgaga cctattctga ccaaactata 7260 taaagaaaag ggagtgtata tgacaggaaa agaacttcgc cagtgtatgc taccaaagtc 7320 agcagcttta tctgaaaaac tcaaagtatt ccgagaattt ctcctgccca ggcatcctcc 7380 tatttttcat gagtggtttc tgagaacatt ccctgatcct acatcatggt acagtagtag 7440 atcagcttac tgccgttcca ctgcagtaat gtcaatggtt ggttatattc tggggcttgg 7500 agaccgtcat ggtgaaaata ttctctttga ttctttgact ggtgaatgcg tacatgtaga 7560 tttcaattgt cttttcaata agggagaaac ctttgaagtt ccagaaattg tgccatttcg 7620 cctgactcat aatatggtta atggaatggg tcctatggga acagagggtc tttttcgaag 7680 agcatgtgaa gttacaatga ggctgatgcg tgatcagcga gagcctttaa tgagtgtctt 7740 aaagactttt ctacatgatc ctcttgtgga atggagtaaa ccagtgaaag ggcattccaa 7800 agcgccactg aatgaaactg gagaagttgt caatgaaaag gccaagaccc atgttcttga 7860 cattgagcag cgactacaag gtgtaatcaa gactcgaaat agagtgacag gactgccgtt 7920 atctattgaa ggacatgtgc attaccttat acaagaagct actgatgaaa acttactatg 7980 ccagatgtat cttggttgga ctccatatat gtgaaatgaa attatgtaaa agaatatgtt 8040 aataatctaa aagtaatgca tttggtatga atctgtggtt gtatctgttc aattctaaag 8100 tacaacataa atttacgttc tcagcaactg ttatttctct ctgatcatta attatatgta 8160 aaataatata cattcagtta ttaagaaata aactgctttc ttaataaaaa aaaaaaaaaa 8220 aaaaaaaaaa aaaaaaaaa 8239 <210> 250 <211> 8239 <212> DNA <213> Homo sapiens <400> 250 gcgctcttcc ggcagcggta cgtttggaga cgccgggaac ccgcgttggc gtggttgact 60 agtgcctcgc agcctcagca tgggggaaca tggcctggag ctggcttcca tgatccccgc 120 cctgcgggag ctgggcagtg ccacaccaga ggaatataat acagttgtac agaagccaag 180 acaaattctg tgtcaattca ttgaccggat acttacagat gtaaatgttg ttgctgtaga 240 acttgtaaag aaaactgact ctcagccaac ctccgtgatg ttgcttgatt tcatccagca 300 tatcatgaaa tcctccccac ttatgtttgt aaatgtgagt ggaagccatg agcgcaaagg 360 cagttgtatt gaattcagta attggatcat aacgagactt ctgcggattg cagcaactcc 420 ctcctgtcat ttgttacaca agaaaatctg tgaagtcatc tgttcattat tatttctttt 480 taaaagcaag agtcctgcta tttttggggt actcacaaaa gaattattac aactttttga 540 agacttggtt tacctccata gaagaaatgt gatgggtcat gctgtggaat ggccagtggt 600 catgagccga tttttaagtc aattagatga acacatggga tatttacaat cagctccttt 660 gcagttgatg agtatgcaaa atttagaatt tattgaagtc actttattaa tggttcttac 720 tcgtattatt gcaattgtgt tttttagaag gcaagaactc ttactttggc agataggttg 780 tgttctgcta gagtatggta gtccaaaaat taaatcccta gcaattagct ttttaacaga 840 actttttcag cttggaggac taccagcaca accagctagc acttttttca gctcattttt 900 ggaattatta aaacaccttg tagaaatgga tactgaccaa ttgaaactct atgaagagcc 960 attatcaaag ctgataaaga cactatttcc ctttgaagca gaagcttata gaaatattga 1020 acctgtctat ttaaatatgc tgctggaaaa actctgtgtc atgtttgaag acggtgtgct 1080 catgcggctt aagtctgatt tgctaaaagc agctttgtgc catttactgc agtatttcct 1140 taaatttgtg ccagctgggt atgaatctgc tttacaagtc aggaaggtct atgtgagaaa 1200 tatttgtaaa gctcttttgg atgtgcttgg aattgaggta gatgcagagt acttgttggg 1260 cccactttat gcagctttga aaatggaaag tatggaaatc attgaggaga ttcaatgcca 1320 aactcaacag gaaaacctca gcagtaatag tgatggaata tcacccaaaa ggcgtcgtct 1380 cagctcgtct ctaaaccctt ctaaaagagc accaaaacag actgaggaaa ttaaacatgt 1440 ggacatgaac caaaagagca tattatggag tgcactgaaa cagaaagctg aatcccttca 1500 gatttccctt gaatacagtg gcctaaagaa tcctgttatt gagatgttag aaggaattgc 1560 tgttgtctta caactgactg ctctgtgtac tgttcattgt tctcatcaaa acatgaactg 1620 ccgtactttc aaggactgtc aacataaatc caagaagaaa ccttctgtag tgataacttg 1680 gatgtcattg gatttttaca caaaagtgct taagagctgt agaagtttgt tagaatctgt 1740 tcagaaactg gacctggagg caaccattga taaggtggtg aaaatttatg atgctttgat 1800 ttatatgcaa gtaaacagtt catttgaaga tcatatcctg gaagatttat gtggtatgct 1860 ctcacttcca tggatttatt cccattctga tgatggctgt ttaaagttga ccacatttgc 1920 cgctaatctt ctaacattaa gctgtaggat ttcagatagc tattcaccac aggcacaatc 1980 acgatgtgtg tttcttctga ctctgtttcc aagaagaata ttccttgagt ggagaacagc 2040 agtttacaac tgggccctgc agagctccca tgaagtaatc cgggctagtt gtgttagtgg 2100 attttttatc ttattgcagc agcagaattc ttgtaacaga gttcccaaga ttcttataga 2160 taaagtcaaa gatgattctg acattgtcaa gaaagaattt gcttctatac ttggtcaact 2220 tgtctgtact cttcacggca tgttttatct gacaagttct ttaacagaac ctttctctga 2280 acacggacat gtggacctct tctgtaggaa cttgaaagcc acttctcaac atgaatgttc 2340 atcttctcaa ctaaaagctt ctgtctgcaa gccattcctt ttcctactga aaaaaaaaat 2400 acctagtcca gtaaaacttg ctttcataga taatctacat catctttgta agcatcttga 2460 ttttagagaa gatgaaacag atgtaaaagc agttcttgga actttattaa atttaatgga 2520 agatccagac aaagatgtta gagtggcttt tagtggaaat atcaagcaca tattggaatc 2580 cttggactct gaagatggat ttataaagga gctttttgtc ttaagaatga aggaagcata 2640 tacacatgcc caaatatcaa gaaataatga gctgaaggat accttgattc ttacaacagg 2700 ggatattgga agggccgcaa aaggagattt ggtaccattt gcactcttac acttattgca 2760 ttgtttgtta tccaagtcag catctgtctc tggagcagca tacacagaaa ttagagctct 2820 ggttgcagct aaaagtgtta aactgcaaag ttttttcagc cagtataaga aacccatctg 2880 tcagtttttg gtagaatccc ttcactctag tcagatgaca gcacttccga atactccatg 2940 ccagaatgct gacgtgcgaa aacaagatgt ggctcaccag agagaaatgg ctttaaatac 3000 gttgtctgaa attgccaacg ttttcgactt tcctgatctt aatcgttttc ttactaggac 3060 attacaagtt ctactacctg atcttgctgc caaagcaagc cctgcagctt ctgctctcat 3120 tcgaacttta ggaaaacaat taaatgtcaa tcgtagagag attttaataa acaacttcaa 3180 atatattttt tctcatttgg tctgttcttg ttccaaagat gaattagaac gtgcccttca 3240 ttatctgaag aatgaaacag aaattgaact ggggagcctg ttgagacaag atttccaagg 3300 attgcataat gaattattgc tgcgtattgg agaacactat caacaggttt ttaatggttt 3360 gtcaatactt gcctcatttg catccagtga tgatccatat cagggcccga gagatatcat 3420 atcacctgaa ctgatggctg attatttaca acccaaattg ttgggcattt tggctttttt 3480 taacatgcag ttactgagct ctagtgttgg cattgaagat aagaaaatgg ccttgaacag 3540 tttgatgtct ttgatgaagt taatgggacc caaacatgtc agttctgtga gggtgaagat 3600 gatgaccaca ctgagaactg gccttcgatt caaggatgat tttcctgaat tgtgttgcag 3660 agcttgggac tgctttgttc gctgcctgga tcatgcttgt ctgggctccc ttctcagtca 3720 tgtaatagta gctttgttac ctcttataca catccagcct aaagaaactg cagctatctt 3780 ccactacctc ataattgaaa acagggatgc tgtgcaagat tttcttcatg aaatatattt 3840 tttacctgat catccagaat taaaaaagat aaaagccgtt ctccaggaat acagaaagga 3900 gacctctgag agcactgatc ttcagacaac tcttcagctc tctatgaagg ccattcaaca 3960 tgaaaatgtc gatgttcgta ttcatgctct tacaagcttg aaggaaacct tgtataaaaa 4020 tcaggaaaaa ctgataaagt atgcaacaga cagtgaaaca gtagaaccta ttatctcaca 4080 gttggtgaca gtgcttttga aaggttgcca agatgcaaac tctcaagctc ggttgctctg 4140 tggggaatgt ttaggggaat tgggggcgat agatccaggt cgattagatt tctcaacaac 4200 tgaaactcaa ggaaaagatt ttacatttgt gactggagta gaagattcaa gctttgccta 4260 tggattattg atggagctaa caagagctta ccttgcgtat gctgataata gccgagctca 4320 agattcagct gcctatgcca ttcaggagtt gctttctatt tatgactgta gagagatgga 4380 gaccaacggc ccaggtcacc aattgtggag gagatttcct gagcatgttc gggaaatact 4440 agaacctcat ctaaatacca gatacaagag ttctcagaag tcaaccgatt ggtctggagt 4500 aaagaagcca atttacttaa gtaaattggg tagtaacttt gcagaatggt cagcatcttg 4560 ggcaggttat cttattacaa aggttcgaca tgatcttgcc agtaaaattt tcacctgctg 4620 tagcattatg atgaagcatg atttcaaagt gaccatctat cttcttccac atattctggt 4680 gtatgtctta ctgggttgta atcaagaaga tcagcaggag gtttatgcag aaattatggc 4740 agttctaaag catgacgatc agcataccat aaatacccaa gacattgcat ctgatctgtg 4800 tcaactcagt acacagactg tgttctccat gcttgaccat ctcacacagt gggcaaggca 4860 caaatttcag gcactgaaag ctgagaaatg tccacacagc aaatcaaaca gaaataaggt 4920 agactcaatg gtatctactg tggattatga agactatcag agtgtaaccc gttttctaga 4980 cctcataccc caggatactc tggcagtagc ttcctttcgc tccaaagcat acacacgagc 5040 tgtaatgcac tttgaatcat ttattacaga aaagaagcaa aatattcagg aacatcttgg 5100 atttttacag aaattgtatg ctgctatgca tgaacctgat ggagtggccg gagtcagtgc 5160 aattagaaag gcagaaccat ctctaaaaga acagatcctt gaacatgaaa gccttggctt 5220 gctgagggat gccactgctt gttatgacag ggctattcag ctagaaccag accagatcat 5280 tcattatcat ggtgtagtaa agtccatgtt aggtcttggt cagctgtcta ctgttatcac 5340 tcaggtgaat ggagtgcatg ctaacaggtc cgagtggaca gatgaattaa acacgtacag 5400 agtggaagca gcttggaaat tgtcacagtg ggatttggtg gaaaactatt tggcagcaga 5460 tggaaaatct acaacatgga gtgtcagact gggacagcta ttattatcag ccaaaaaaag 5520 agatatcaca gctttttatg actcactgaa actagtgaga gcagaacaaa ttgtacctct 5580 ttcagctgca agctttgaaa gaggctccta ccaacgagga tatgaatata ttgtgagatt 5640 gcacatgtta tgtgagttgg agcatagcat caaaccactt ttccagcatt ctccaggtga 5700 cagttctcaa gaagattctc taaactgggt agctcgacta gaaatgaccc agaattccta 5760 cagagccaag gagcctatcc tggctctccg gagggcttta ctaagcctca acaaaagacc 5820 agattacaat gaaatggttg gagaatgctg gctgcagagt gccagggtag ctagaaaggc 5880 tggtcaccac cagacagcct acaatgctct ccttaatgca ggggaatcac gactcgctga 5940 actgtacgtg gaaagggcaa agtggctctg gtccaagggt gatgttcacc aggcactaat 6000 tgttcttcaa aaaggtgttg aattatgttt tcctgaaaat gaaaccccac ctgagggtaa 6060 gaacatgtta atccatggtc gagctatgct actagtgggc cgatttatgg aagaaacagc 6120 taactttgaa agcaatgcaa ttatgaaaaa atataaggat gtgaccgcgt gcctgccaga 6180 atgggaggat gggcattttt accttgccaa gtactatgac aaattgatgc ccatggtcac 6240 agacaacaaa atggaaaagc aaggtgatct catccggtat atagttcttc attttggcag 6300 atctctacaa tatggaaatc agttcatata tcagtcaatg ccacgaatgt taactctatg 6360 gcttgattat ggtacaaagg catatgaatg ggaaaaagct ggccgctccg atcgtgtaca 6420 aatgaggaat gatttgggta aaataaacaa ggttatcaca gagcatacaa actatttagc 6480 tccatatcaa tttttgactg ctttttcaca attgatctct cgaatttgtc attctcacga 6540 tgaagttttt gttgtcttga tggaaataat agccaaagta tttctagcct atcctcaaca 6600 agcaatgtgg atgatgacag ctgtgtcaaa gtcatcttat cccatgcgtg tgaacagatg 6660 caaggaaatc ctcaataaag ctattcatat gaaaaaatcc ttagagaagt ttgttggaga 6720 tgcaactcgc ctaacagata agcttctaga attgtgcaat aaaccggttg atggaagtag 6780 ttccacatta agcatgagca ctcattttaa aatgcttaaa aagctggtag aagaagcaac 6840 atttagtgaa atcctcattc ctctacaatc agtcatgata cctacacttc catcaattct 6900 gggtacccat gctaaccatg ctagccatga accatttcct ggacattggg cctatattgc 6960 agggtttgat gatatggtgg aaattcttgc ttctcttcag aaaccaaaga agatttcttt 7020 aaaaggctca gatggaaagt tctacatcat gatgtgtaag ccaaaagatg acctgagaaa 7080 ggattgtaga ctaatggaat tcaattcctt gattaataag tgcttaagaa aagatgcaga 7140 gtctcgtaga agagaacttc atattcgaac atatgcagtt attccactaa atgatgaatg 7200 tgggattatt gaatgggtga acaacactgc tggtttgaga cctattctga ccaaactata 7260 taaagaaaag ggagtgtata tgacaggaaa agaacttcgc cagtgtatgc taccaaagtc 7320 agcagcttta tctgaaaaac tcaaagtatt ccgagaattt ctcctgccca ggcatcctcc 7380 tatttttcat gagtggtttc tgagaacatt ccctgatcct acatcatggt acagtagtag 7440 atcagcttac tgccgttcca ctgcagtaat gtcaatggtt ggttatattc tggggcttgg 7500 agaccgtcat ggtgaaaata ttctctttga ttctttgact ggtgaatgcg tacatgtaga 7560 tttcaattgt cttttcaata agggagaaac ctttgaagtt ccagaaattg tgccatttcg 7620 cctgactcat aatatggtta atggaatggg tcctatggga acagagggtc tttttcgaag 7680 agcatgtgaa gttacaatga ggctgatgcg tgatcagcga gagcctttaa tgagtgtctt 7740 aaagactttt ctacatgatc ctcttgtgga atggagtaaa ccagtgaaag ggcattccaa 7800 agcgccactg aatgaaactg gagaagttgt caatgaaaag gccaagaccc atgttcttga 7860 cattgagcag cgactacaag gtgtaatcaa gactcgaaat agagtgacag gactgccgtt 7920 atctattgaa ggacatgtgc attaccttat acaagaagct actgatgaaa acttactatg 7980 ccagatgtat cttggttgga ctccatatat gtgaaatgaa attatgtaaa agaatatgtt 8040 aataatctaa aagtaatgca tttggtatga atctgtggtt gtatctgttc aattctaaag 8100 tacaacataa atttacgttc tcagcaactg ttatttctct ctgatcatta attatatgta 8160 aaataatata cattcagtta ttaagaaata aactgctttc ttaataaaaa aaaaaaaaaa 8220 aaaaaaaaaa aaaaaaaaa 8239 <210> 251 <211> 8210 <212> DNA <213> Homo sapiens <400> 251 gcctccacac ggctccgtcg ggcgccgcgc tcttccggca gcggtagctt tggagacgcc 60 gggaacccgc gttggcgtgg ttgactagtg cctcgcagcc tcagcatggg ggaacatggc 120 ctggagctgg cttccatgat ccccgccctg cgggagctgg gcagtgccac accagaggaa 180 tataatacag ttgtacagaa gccaagacaa attctgtgtc aattcattga ccggatactt 240 acagatgtaa atgttgttgc tgtagaactt gtaaagaaaa ctgactctca gccaacctcc 300 gtgatgttgc ttgatttcat ccagcatatc atgaaatcct ccccacttat gtttgtaaat 360 gtgagtggaa gccatgaggc caaaggcagt tgtattgaat tcagtaattg gatcataacg 420 agacttctgc ggattgcagc aactccctcc tgtcatttgt tacacaagaa aatctgtgaa 480 gtcatctgtt cattattatt tctttttaaa agcaagagtc ctgctatttt tggggtactc 540 acaaaagaat tattacaact ttttgaagac ttggtttacc tccatagaag aaatgtgatg 600 ggtcatgctg tggaatggcc agtggtcatg agccgatttt taagtcaatt agatgaacac 660 atgggatatt tacaatcagc tcctttgcag ttgatgagta tgcaaaattt agaatttatt 720 gaagtcactt tattaatggt tcttactcgt attattgcaa ttgtgttttt tagaaggcaa 780 gaactcttac tttggcagat aggttgtgtt ctgctagagt atggtagtcc aaaaattaaa 840 tccctagcaa ttagcttttt aacagaactt tttcagcttg gaggactacc agcacaacca 900 gctagcactt ttttcagctc atttttggaa ttattaaaac accttgtaga aatggatact 960 gaccaattga aactctatga agagccatta tcaaagctga taaagacact atttcccttt 1020 gaagcagaag cttatagaaa tattgaacct gtctatttaa atatgctgct ggaaaaactc 1080 tgtgtcatgt ttgaagacgg tgtgctcatg cggcttaagt ctgatttgct aaaagcagct 1140 ttgtgccatt tactgcagta tttccttaaa tttgtgccag ctgggtatga atctgcttta 1200 caagtcagga aggtctatgt gagaaatatt tgtaaagctc ttttggatgt gcttggaatt 1260 gaggtagatg cagagtactt gttgggccca ctttatgcag ctttgaaaat ggaaagtatg 1320 gaaatcattg aggagattca atgccaaact caacaggaaa acctcagcag taatagtgat 1380 ggaatatcac ccaaaaggcg tcgtctcagc tcgtctctaa acccttctaa aagagcacca 1440 aaacagactg aggaaattaa acatgtggac atgaaccaaa agagcatatt atggagtgca 1500 ctgaaacaga aagctgaatc ccttcagatt tcccttgaat acagtggcct aaagaatcct 1560 gttattgaga tgttagaagg aattgctgtt gtcttacaac tgactgctct gtgtactgtt 1620 cattgttctc atcaaaacat gaactgccgt actttcaagg actgtcaaca taaatccaag 1680 aagaaacctt ctgtagtgat aacttggatg tcattggatt tttacacaaa agtgcttaag 1740 agctgtagaa gtttgttaga atctgttcag aaactggacc tggaggcaac cattgataag 1800 gtggtgaaaa tttatgatgc tttgatttat atgcaagtaa acagttcatt tgaagatcat 1860 atcctggaag atttatgtgg tatgctctca cttccatgga tttattccca ttctgatgat 1920 ggctgtttaa agttgaccac atttgccgct aatcttctaa cattaagctg taggatttca 1980 gatagctatt caccacaggc acaatcacga tgtgtgtttc ttctgactct gtttccaaga 2040 agaatattcc ttgagtggag aacagcagtt tacaactggg ccctgcagag ctcccatgaa 2100 gtaatccggg ctagttgtgt tagtggattt tttatcttat tgcagcagca gaattcttgt 2160 aacagagttc ccaagattct tatagataaa gtcaaagatg attctgacat tgtcaagaaa 2220 gaatttgctt ctatacttgg tcaacttgtc tgtactcttc acggcatgtt ttatctgaca 2280 agttctttaa cagaaccttt ctctgaacac ggacatgtgg acctcttctg taggaacttg 2340 aaagccactt ctcaacatga atgttcatct tctcaactaa aagcttctgt ctgcaagcca 2400 ttccttttcc tactgaaaaa aaaaatacct agtccagtaa aacttgcttt catagataat 2460 ctacatcatc tttgtaagca tcttgatttt agagaagatg aaacagatgt aaaagcagtt 2520 cttggaactt tattaaattt aatggaagat ccagacaaag atgttagagt ggcttttagt 2580 ggaaatatca agcacatatt ggaatccttg gactctgaag atggatttat aaaggagctt 2640 tttgtcttaa gaatgaagga agcatataca catgcccaaa tatcaagaaa taatgagctg 2700 aaggatacct tgattcttac aacaggggat attggaaggg ccgcaaaagg agatttggta 2760 ccatttgcac tcttacactt attgcattgt ttgttatcca agtcagcatc tgtctctgga 2820 gcagcataca cagaaattag agctctggtt gcagctaaaa gtgttaaact gcaaagtttt 2880 ttcagccagt ataagaaacc catctgtcag tttttggtag aatcccttca ctctagtcag 2940 atgacagcac ttccgaatac tccatgccag aatgctgacg tgcgaaaaca agatgtggct 3000 caccagagag aaatggcttt aaatacgttg tctgaaattg ccaacgtttt cgactttcct 3060 gatcttaatc gttttcttac taggacatta caagttctac tacctgatct tgctgccaaa 3120 gcaagccctg cagcttctgc tctcattcga actttaggaa aacaattaaa tgtcaatcgt 3180 agagagattt taataaacaa cttcaaatat attttttctc atttggtctg ttcttgttcc 3240 aaagatgaat tagaacgtgc ccttcattat ctgaagaatg aaacagaaat tgaactgggg 3300 agcctgttga gacaagattt ccaaggattg cataatgaat tattgctgcg tattggagaa 3360 cactatcaac aggtttttaa tggtttgtca atacttgcct catttgcatc cagtgatgat 3420 ccatatcagg gcccgagaga tatcatatca cctgaactga tggctgatta tttacaaccc 3480 aaattgttgg gcattttggc tttttttaac atgcagttac tgagctctag tgttggcatt 3540 gaagataaga aaatggcctt gaacagtttg atgtctttga tgaagttaat gggacccaaa 3600 catgtcagtt ctgtgagggt gaagatgatg accacactga gaactggcct tcgattcaag 3660 gatgattttc ctgaattgtg ttgcagagct tgggactgct ttgttcgctg cctggatcat 3720 gcttgtctgg gctcccttct cagtcatgta atagtagctt tgttacctct tatacacatc 3780 cagcctaaag aaactgcagc tatcttccac tacctcataa ttgaaaacag ggatgctgtg 3840 caagattttc ttcatgaaat atatttttta cctgatcatc cagaattaaa aaagataaaa 3900 gccgttctcc aggaatacag aaaggagacc tctgagagca ctgatcttca gacaactctt 3960 cagctctcta tgaaggccat tcaacatgaa aatgtcgatg ttcgtattca tgctcttaca 4020 agcttgaagg aaaccttgta taaaaatcag gaaaaactga taaagtatgc aacagacagt 4080 gaaacagtag aacctattat ctcacagttg gtgacagtgc ttttgaaagg ttgccaagat 4140 gcaaactctc aagctcggtt gctctgtggg gaatgtttag gggaattggg ggcgatagat 4200 ccaggtcgat tagatttctc aacaactgaa actcaaggaa aagattttac atttgtgact 4260 ggagtagaag attcaagctt tgcctatgga ttattgatgg agctaacaag agcttacctt 4320 gcgtacgctg ataatagccg agctcaagat tcagctgcct atgccattca ggagttgctt 4380 tctatttatg actgtagaga gatggagacc aacggcccag gtcaccaatt gtggaggaga 4440 tttcctgagc atgttcggga aatactagaa cctcatctaa ataccagata caagagttct 4500 cagaagtcaa ccgattggtc tggagtaaag aagccaattt acttaagtaa attgggtagt 4560 aactttgcag aatggtcagc atcttgggca ggttatctta ttacaaaggt tcgacatgat 4620 cttgccagta aaattttcac ctgctgtagc attatgatga agcatgattt caaagtgacc 4680 atctatcttc ttccacatat tctggtgtat gtcttactgg gttgtaatca agaagatcag 4740 caggaggttt atgcagaaat tatggcagtt ctaaagcatg acgatcagca taccataaat 4800 acccaagaca ttgcatctga tctgtgtcaa ctcagtacac agactgtgtt ctccatgctt 4860 gaccatctca cacagtgggc aaggcacaaa tttcaggcac tgaaagctga gaaatgtcca 4920 cacagcaaat caaacagaaa taaggtagac tcaatggtat ctactgtgga ttatgaagac 4980 tatcagagtg taacccgttt tctagacctc ataccccagg atactctggc agtagcttcc 5040 tttcgctcca aagcatacac acgagctgta atgcactttg aatcatttat tacagaaaag 5100 aagcaaaata ttcaggaaca tcttggattt ttacagaaat tgtatgctgc tatgcatgaa 5160 cctgatggag tggccggagt cagtgcaatt agaaaggcag aaccatctct aaaagaacag 5220 atccttgaac atgaaagcct tggcttgctg agggatgcca ctgcttgtta tgacagggct 5280 attcagctag aaccagacca gatcattcat tatcatggtg tagtaaagtc catgttaggt 5340 cttggtcagc tgtctactgt tatcactcag gtgaatggag tgcatgctaa caggtccgag 5400 tggacagatg aattaaacac gtacagagtg gaagcagctt ggaaattgtc acagtgggat 5460 ttggtggaaa actatttggc agcagatgga aaatctacaa catggagtgt cagactggga 5520 cagctattat tatcagccaa aaaaagagat atcacagctt tttatgactc actgaaacta 5580 gtgagagcag aacaaattgt acctctttca gctgcaagct ttgaaagagg ctcctaccaa 5640 cgaggatatg aatatattgt gagattgcac atgttatgtg agttggagca tagcatcaaa 5700 ccacttttcc agcattctcc aggtgacagt tctcaagaag attctctaaa ctgggtagct 5760 cgactagaaa tgacccagaa ttcctacaga gccaaggagc ctatcctggc tctccggagg 5820 gctttactaa gcctcaacaa aagaccagat tacaatgaaa tggttggaga atgctggctg 5880 cagagtgcca gggtagctag aaaggctggt caccaccaga cagcctacaa tgctctcctt 5940 aatgcagggg aatcacgact cgctgaactg tacgtggaaa gggcaaagtg gctctggtcc 6000 aagggtgatg ttcaccaggc actaattgtt cttcaaaaag gtgttgaatt atgttttcct 6060 gaaaatgaaa ccccacctga gggtaagaac atgttaatcc atggtcgagc tatgctacta 6120 gtgggccgat ttatggaaga aacagctaac tttgaaagca atgcaattat gaaaaaatat 6180 aaggatgtga ccgcgtgcct gccagaatgg gaggatgggc atttttacct tgccaagtac 6240 tatgacaaat tgatgcccat ggtcacagac aacaaaatgg aaaagcaagg tgatctcatc 6300 cggtatatag ttcttcattt tggcagatct ctacaatatg gaaatcagtt catatatcag 6360 tcaatgccac gaatgttaac tctatggctt gattatggta caaaggcata tgaatgggaa 6420 aaagctggcc gctccgatcg tgtacaaatg aggaatgatt tgggtaaaat aaacaaggtt 6480 atcacagagc atacaaacta tttagctcca tatcaatttt tgactgcttt ttcacaattg 6540 atctctcgaa tttgtcattc tcacgatgaa gtttttgttg tcttgatgga aataatagcc 6600 aaagtatttc tagcctatcc tcaacaagca atgtggatga tgacagctgt gtcaaagtca 6660 tcttatccca tgcgtgtgaa cagatgcaag gaaatcctca ataaagctat tcatatgaaa 6720 aaatccttag agaagtttgt tggagatgca actcgcctaa cagataagct tctagaattg 6780 tgcaataaac cggttgatgg aagtagttcc acattaagca tgagcactca ttttaaaatg 6840 cttaaaaagc tggtagaaga agcaacattt agtgaaatcc tcattcctct acaatcagtc 6900 atgataccta cacttccatc aattctgggt acccatgcta accatgctag ccatgaacca 6960 tttcctggac attgggccta tattgcaggg tttgatgata tggtggaaat tcttgcttct 7020 cttcagaaac caaagaagat ttctttaaaa ggctcagatg gaaagttcta catcatgatg 7080 tgtaagccaa aagatgacct gagaaaggat tgtagactaa tggaattcaa ttccttgatt 7140 aataagtgct taagaaaaga tgcagagtct cgtagaagag aacttcatat tcgaacatat 7200 gcagttattc cactaaatga tgaatgtggg attattgaat gggtgaacaa cactgctggt 7260 ttgagaccta ttctgaccaa actatataaa gaaaagggag tgtatatgac aggaaaagaa 7320 cttcgccagt gtatgctacc aaagtcagca gctttatctg aaaaactcaa agtattccga 7380 gaatttctcc tgcccaggca tcctcctatt tttcatgagt ggtttctgag aacattccct 7440 gatcctacat catggtacag tagtagatca gcttactgcc gttccactgc agtaatgtca 7500 atggttggtt atattctggg gcttggagac cgtcatggtg aaaatattct ctttgattct 7560 ttgactggtg aatgcgtaca tgtagatttc aattgtcttt tcaataaggg agaaaccttt 7620 gaagttccag aaattgtgcc atttcgcctg actcataata tggttaatgg aatgggtcct 7680 atgggaacag agggtctttt tcgaagagca tgtgaagtta caatgaggct gatgcgtgat 7740 cagcgagagc ctttaatgag tgtcttaaag acttttctac atgatcctct tgtggaatgg 7800 agtaaaccag tgaaagggca ttccaaagcg ccactgaatg aaactggaga agttgtcaat 7860 gaaaaggcca agacccatgt tcttgacatt gagcagcgac tacaaggtgt aatcaagact 7920 cgaaatagag tgacaggact gccgttatct attgaaggac atgtgcatta ccttatacag 7980 gaagctactg atgaaaactt actatgccag atgtatcttg gttggactcc atatatgtga 8040 aatgaaatta tgtaaaagaa tatgttaata atctaaaagt aatgcatttg gtatgaatct 8100 gtggttgtat ctgttcaatt ctaaagtaca acataaattt acgttctcag caactgttat 8160 ttctctctga tcattaatta tatgtaaaat aatatacatt cactcgtgcc 8210 <210> 252 <211> 2042 <212> DNA <213> Homo sapiens <400> 252 ggggccagtc gttcgccgga aagcatttgt ctcccacctc atcataacaa caattaattt 60 cctctggggc ctgaggaggg cagaatttca accttcggtg tgcttgggag tggcgattgt 120 gatttacacg acaaaatgcc gaggtgctcg gtggagtcat ggcagtgccc tttgtggaag 180 actgggactt ggtgcaaacc ctgggagaag gtgcctatgg agaagttcaa cttgctgtga 240 atagagtaac tgaagaagca gtcgcagtga agattgtaga tatgaagcgt gccgtagact 300 gtccagaaaa tattaagaaa gagatctgta tcaataaaat gctaaatcat gaaaatgtag 360 taaaattcta tggtcacagg agagaaggca atatccaata tttatttctg gagtactgta 420 gtggaggaga gctttttgac agaatagagc cagacatagg catgcctgaa ccagatgctc 480 agagattctt ccatcaactc atggcagggg tggtttatct gcatggtatt ggaataactc 540 acagggatat taaaccagaa aatcttctgt tggatgaaag ggataacctc aaaatctcag 600 actttggctt ggcaacagta tttcggtata ataatcgtga gcgtttgttg aacaagatgt 660 gtggtacttt accatatgtt gctccagaac ttctgaagag aagagaattt catgcagaac 720 cagttgatgt ttggtcctgt ggaatagtac ttactgcaat gctcgctgga gaattgccat 780 gggaccaacc cagtgacagc tgtcaggagt attctgactg gaaagaaaaa aaaacatacc 840 tcaacccttg gaaaaaaatc gattctgctc ctctagctct gctgcataaa atcttagttg 900 agaatccatc agcaagaatt accattccag acatcaaaaa agatagatgg tacaacaaac 960 ccctcaagaa aggggcaaaa aggccccgag tcacttcagg tggtgtgtca gagtctccca 1020 gtggattttc taagcacatt caatccaatt tggacttctc tccagtaaac agtgcttcta 1080 gtgaagaaaa tgtgaagtac tccagttctc agccagaacc ccgcacaggt ctttccttat 1140 gggataccag cccctcatac attgataaat tggtacaagg gatcagcttt tcccagccca 1200 catgtcctga tcatatgctt ttgaatagtc agttacttgg caccccagga tcctcacaga 1260 acccctggca gcggttggtc aaaagaatga cacgattctt taccaaattg gatgcagaca 1320 aatcttatca atgcctgaaa gagacttgtg agaagttggg ctatcaatgg aagaaaagtt 1380 gtatgaatca ggttactata tcaacaactg ataggagaaa caataaactc attttcaaag 1440 tgaatttgtt agaaatggat gataaaatat tggttgactt ccggctttct aagggtgatg 1500 gattggagtt caagagacac ttcctgaaga ttaaagggaa gctgattgat attgtgagca 1560 gccagaaggt ttggcttcct gccacatgat cggaccatcg gctctgggga atcctggtga 1620 atatagtgct gctatgttga cattattctt cctagagaag attatcctgt cctgcaaact 1680 gcaaatagta gttcctgaag tgttcacttc cctgtttatc caaacatctt ccaatttatt 1740 ttgtttgttc ggcatacaaa taatacctat atcttaattg taagcaaaac tttggggaaa 1800 ggatgaatag aattcatttg attatttctt catgtgtgtt tagtatctga atttgaaact 1860 catctggtgg aaaccaagtt tcaggggaca tgagttttcc agcttttata cacacgtatc 1920 tcatttttat caaaacattt tgtttaattc aaaaagtaca tatttcttcc atgttgattt 1980 aattctaaga tgaaccaata aagacataat tcttgcaaaa aaaaaaaaaa aaaaaaaaaa 2040 aa 2042 <210> 253 <211> 2042 <212> DNA <213> Homo sapiens <400> 253 ggggccagtc gttcgccgga aagcatttgt ctcccacctc atcataacaa caattaattt 60 cctctggggc ctgaggaggg cagaatttca accttcggtg tgcttgggag tggcgattgt 120 gatttacacg acaaaatgcc gaggtgctcg gtggagtcat ggcagtgccc tttgtggaag 180 actgggactt ggtgcaaacc ctgggagaag gtgcctatgg agaagttcaa cttgctgtga 240 atagagtaac tgaagaagca gtcgcagtga agattgtaga tatgaagcgt gccgtagact 300 gtccagaaaa tattaagaaa gagatctgta tcaataaaat gctaaatcat gaaaatgtag 360 taaaattcta tggtcacagg agagaaggca atatccaata tttatttctg gagtactgta 420 gtggaggaga gctttttgac agaatagagc cagacatagg catgcctgaa ccagatgctc 480 agagattctt ccatcaactc atggcagggg tggtttatct gcatggtatt ggaataactc 540 acagggatat taaaccagaa aatcttctgt tggatgaaag ggataacctc aaaatctcag 600 actttggctt ggcaacagta tttcggtata ataatcgtga gcgtttgttg aacaagatgt 660 gtggtacttt accatatgtt gctccagaac ttctgaagag aagagaattt catgcagaac 720 cagttgatgt ttggtcctgt ggaatagtac ttactgcaat gctcgctgga gaattgccat 780 gggaccaacc cagtgacagc tgtcaggagt attctgactg gaaagaaaaa aaaacatacc 840 tcaacccttg gaaaaaaatc gattctgctc ctctagctct gctgcataaa atcttagttg 900 agaatccatc agcaagaatt accattccag acatcaaaaa agatagatgg tacaacaaac 960 ccctcaagaa aggggcaaaa aggccccgag tcacttcagg tggtgtgtca gagtctccca 1020 gtggattttc taagcacatt caatccaatt tggacttctc tccagtaaac agtgcttcta 1080 gtgaagaaaa tgtgaagtac tccagttctc agccagaacc ccgcacaggt ctttccttat 1140 gggataccag cccctcatac attgataaat tggtacaagg gatcagcttt tcccagccca 1200 catgtcctga tcatatgctt ttgaatagtc agttacttgg caccccagga tcctcacaga 1260 acccctggca gcggttggtc aaaagaatga cacgattctt taccaaattg gatgcagaca 1320 aatcttatca atgcctgaaa gagacttgtg agaagttggg ctatcaatgg aagaaaagtt 1380 gtatgaatca ggttactata tcaacaactg ataggagaaa caataaactc attttcaaag 1440 tgaatttgtt agaaatggat gataaaatat tggttgactt ccggctttct aagggtgatg 1500 gattggagtt caagagacac ttcctgaaga ttaaagggaa gctgattgat attgtgagca 1560 gccagaaggt ttggcttcct gccacatgat cggaccatcg gctctgggga atcctggtga 1620 atatagtgct gctatgttga cattattctt cctagagaag attatcctgt cctgcaaact 1680 gcaaatagta gttcctgaag tgttcacttc cctgtttatc caaacatctt ccaatttatt 1740 ttgtttgttc ggcatacaaa taatacctat atcttaattg taagcaaaac tttggggaaa 1800 ggatgaatag aattcatttg attatttctt catgtgtgtt tagtatctga atttgaaact 1860 catctggtgg aaaccaagtt tcaggggaca tgagttttcc agcttttata cacacgtatc 1920 tcatttttat caaaacattt tgtttaattc aaaaagtaca tatttcttcc atgttgattt 1980 aattctaaga tgaaccaata aagacataat tcttgcaaaa aaaaaaaaaa aaaaaaaaaa 2040 aa 2042 <210> 254 <211> 1821 <212> DNA <213> Homo sapiens <400> 254 ggccggacag tccgccgagg tgctcggtgg agtcatggca gtgccctttg tggaagactg 60 ggacttggtg caaaccctgg gagaaggtgc ctatggagaa gttcaacttg ctgtgaatag 120 agtaactgaa gaagcagtcg cagtgaagat tgtagatatg aagcgtgccg tagactgtcc 180 agaaaatatt aagaaagaga tctgtatcaa taaaatgcta aatcatgaaa atgtagtaaa 240 attctatggt cacaggagag aaggcaatat ccaatattta tttctggagt actgtagtgg 300 aggagagctt tttgacagaa tagagccaga cataggcatg cctgaaccag atgctcagag 360 attcttccat caactcatgg caggggtggt ttatctgcat ggtattggaa taactcacag 420 ggatattaaa ccagaaaatc ttctgttgga tgaaagggat aacctcaaaa tctcagactt 480 tggcttggca acagtatttc ggtataataa tcgtgagcgt ttgttgaaca agatgtgtgg 540 tactttacca tatgttgctc cagaacttct gaagagaaga gaatttcatg cagaaccagt 600 tgatgtttgg tcctgtggaa tagtacttac tgcaatgctc gctggagaat tgccatggga 660 ccaacccagt gacagctgtc aggagtattc tgactggaaa gaaaaaaaaa catacctcaa 720 cccttggaaa aaaatcgatt ctgctcctct agctctgctg cataaaatct tagttgagaa 780 tccatcagca agaattacca ttccagacat caaaaaagat agatggtaca acaaacccct 840 caagaaaggg gcaaaaaggc cccgagtcac ttcaggtggt gtgtcagagt ctcccagtgg 900 attttctaag cacattcaat ccaatttgga cttctctcca gtaaacagtg cttctagtga 960 agaaaatgtg aagtactcca gttctcagcc agaaccccgc acaggtcttt ccttatggga 1020 taccagcccc tcatacattg ataaattggt acaagggatc agcttttccc agcccacatg 1080 tcctgatcat atgcttttga atagtcagtt acttggcacc ccaggatcct cacagaaccc 1140 ctggcagcgg ttggtcaaaa gaatgacacg attctttacc aaattggatg cagacaaatc 1200 ttatcaatgc ctgaaagaga cttgtgagaa gttgggctat caatggaaga aaagttgtat 1260 gaatcaggtt actatatcaa caactgatag gagaaacaat aaactcattt tcaaagtgaa 1320 tttgttagaa atggatgata aaatattggt tgacttccgg ctttctaagg gtgatggatt 1380 ggagttcaag agacacttcc tgaagattaa agggaagctg attgatattg tgagcagcca 1440 gaaggtttgg cttcctgcca catgatcgga ccatcggctc tggggaatcc tggtgaatat 1500 agtgctgcta tgttgacatt attcttccta gagaagatta tcctgtcctg caaactgcaa 1560 atagtagttc ctgaagtgtt cacttccctg tttatccaaa catcttccaa tttattttgt 1620 ttgttcggca tacaaataat acctatatct taattgtaag caaaactttg gggaaaggat 1680 gaatagaatt catttgatta tttcttcatg tgtgtttagt atctgaattt gaaactcatc 1740 tggtggaaac caagtttcag gggacatgag ttttccagct tttatacaca cgtatctcat 1800 ttttatcaaa acattttgtt t 1821 <210> 255 <211> 1893 <212> DNA <213> Homo sapiens <400> 255 gcatttggat tcctgcagtg gtgggcaaag gacagtccgc cgaggtgctc ggtggagtca 60 tggcagtgcc ctttgtggaa gactgggact tggtgcaaac cctgggagaa ggtgcctatg 120 gagaagttca acttgctgtg aatagagtaa ctgaagaagc agtcgcagtg aagattgtag 180 atatgaagcg tgccgtagac tgtccagaaa atattaagaa agagatctgt atcaataaaa 240 tgctaaatca tgaaaatgta gtaaaattct atggtcacag gagagaaggc aatatccaat 300 atttatttct ggagtactgt agtggaggag agctttttga cagaatagag ccagacatag 360 gcatgcctga accagatgct cagagattct tccatcaact catggcaggg gtggtttatc 420 tgcatggtat tggaataact cacagggata ttaaaccaga aaatcttctg ttggatgaaa 480 gggataacct caaaatctca gactttggct tggcaacagt atttcggtat aataatcgtg 540 agcgtttgtt gaacaagatg tgtggtactt taccatatgt tgctccagaa cttctgaaga 600 gaagagaatt tcatgcagaa ccagttgatg tttggtcctg tggaatagta cttactgcaa 660 tgctcgctgg agaattgcca tgggaccaac ccagtgacag ctgtcaggag tattctgact 720 ggaaagaaaa aaaaacatac ctcaaccctt ggaaaaaaat cgattctgct cctctagctc 780 tgctgcataa aatcttagtt gagaatccat cagcaagaat taccattcca gacatcaaaa 840 aagatagatg gtacaacaaa cccctcaaga aaggggcaaa aaggccccga gtcacttcag 900 gtggtgtgtc agagtctccc agtggatttt ctaagcacat tcaatccaat ttggacttct 960 ctccagtaaa cagtgcttct agtgaagaaa atgtgaagta ctccagttct cagccagaac 1020 cccgcacagg tctttcctta tgggatacca gcccctcata cattgataaa ttggtacaag 1080 ggatcagctt ttcccagccc acatgtcctg atcatatgct tttgaatagt cagttacttg 1140 gcaccccagg atcctcacag aacccctggc agcggttggt caaaagaatg acacgattct 1200 ttaccaaatt ggatgcagac aaatcttatc aatgcctgaa agagacttgt gagaagttgg 1260 gctatcaatg gaagaaaagt tgtatgaatc aggttactat atcaacaact gataggagaa 1320 acaataaact cattttcaaa gtgaatttgt tagaaatgga tgataaaata ttggttgact 1380 tccggctttc taagggtgat ggattggagt tcaagagaca cttcctgaag attaaaggga 1440 agctgattga tattgtgagc agccagaagg tttggcttcc tgccacatga tcggaccatc 1500 ggctctgggg aatcctgatg gagtttcact cttgtctccc aggctggagt acaatggcat 1560 gatctcagct tactgcaacc tccgtctcct gggttcaagc gattctcctg cctcagcctt 1620 ccaagtagct gggattacag gtgcccacca ccacacctgg ctaggttttg tatttttagt 1680 agagatgggg tttttttcat gttggccagg ctgatctgga actcctgacc tcaagtgatc 1740 cacctgcctt ggcctcccaa agtgctggga ttttaggtgt gagccacctc gcctggcaag 1800 ggattctgtt cttagtcctt gaaaaaataa agttctgaat cttcaaaaaa aaaaaaaaaa 1860 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa 1893 <210> 256 <211> 1428 <212> DNA <213> Homo sapiens <400> 256 atggcagtgc cctttgtgga agactgggac ttggtgcaaa ccctgggaga aggtgcctat 60 ggagaagttc aacttgctgt gaatagagta actgaagaag cagtcgcagt gaagattgta 120 gatatgaagc gtgccgtaga ctgtccagaa aatattaaga aagagatctg tatcaataaa 180 atgctaaatc atgaaaatgt agtaaaattc tatggtcaca ggagagaagg caatatccaa 240 tatttatttc tggagtactg tagtggagga gagctttttg acagaataga gccagacata 300 ggcatgcctg aaccagatgc tcagagattc ttccatcaac tcatggcagg ggtggtttat 360 ctgcatggta ttggaataac tcacagggat attaaaccag aaaatcttct gttggatgaa 420 agggataacc tcaaaatctc agactttggc ttggcaacag tatttcggta taataatcgt 480 gagcgtttgt tgaacaagat gtgtggtact ttaccatatg ttgctccaga acttctgaag 540 agaagagaat ttcatgcaga accagttgat gtttggtcct gtggaatagt acttactgca 600 atgctcgctg gagaattgcc atgggaccaa cccagtgaca gctgtcagga gtattctgac 660 tggaaagaaa aaaaaacata cctcaaccct tggaaaaaaa tcgattctgc tcctctagct 720 ctgctgcata aaatcttagt tgagaatcca tcagcaagaa ttaccattcc agacatcaaa 780 aaagatagat ggtacaacaa acccctcaag aaaggggcaa aaaggccccg agtcacttca 840 ggtggtgtgt cagagtctcc cagtggattt tctaagcaca ttcaatccaa tttggacttc 900 tctccagtaa acagtgcttc tagtgaagaa aatgtgaagt actccagttc tcagccagaa 960 ccccgcacag gtctttcctt atgggatacc agcccctcat acattgataa attggtacaa 1020 gggatcagct tttcccagcc cacatgtcct gatcatatgc ttttgaatag tcagttactt 1080 ggcaccccag gatcctcaca gaacccctgg cagcggttgg tcaaaagaat gacacgattc 1140 tttaccaaat tggatgcaga caaatcttat caatgcctga aagagacttg tgagaagttg 1200 ggctatcaat ggaagaaaag ttgtatgaat caggttacta tatcaacaac tgataggaga 1260 aacaataaac tcattttcaa agtgaatttg ttagaaatgg atgataaaat attggttgac 1320 ttccggcttt ctaagggtga tggattggag ttcaagagac acttcctgaa gattaaaggg 1380 aagctgattg atattgtgag cagccagaag gtttggcttc ctgccaca 1428 <210> 257 <211> 4506 <212> DNA <213> Homo sapiens <400> 257 gatcgcgcac gtcccggagc ccatgccgac cgcaggcgcc gtatccgcgc tcgtctagca 60 gccccggtta cgcggttgca cgtcggcccc agccctgagg agccggaccg atgtggaaac 120 tgctgcccgc cgcgggcccg gcaggaggag aaccatacag acttttgact ggcgttgagt 180 acgttgttgg aaggaaaaac tgtgccattc tgattgaaaa tgatcagtcg atcagccgaa 240 atcatgctgt gttaactgct aacttttctg taaccaacct gagtcaaaca gatgaaatcc 300 ctgtattgac attaaaagat aattctaagt atggtacctt tgttaatgag gaaaaaatgc 360 agaatggctt ttcccgaact ttgaagtcgg gggatggtat tacttttgga gtgtttggaa 420 gtaaattcag aatagagtat gagcctttgg ttgcatgctc ttcttgttta gatgtctctg 480 ggaaaactgc tttaaatcaa gctatattgc aacttggagg atttactgta aacaattgga 540 cagaagaatg cactcacctt gtcatggtat cagtgaaagt taccattaaa acaatatgtg 600 cactcatttg tggacgtcca attgtaaagc cagaatattt tactgaattc ctgaaagcag 660 ttgagtccaa gaagcagcct ccacaaattg aaagttttta cccacctctt gatgaaccat 720 ctattggaag taaaaatgtt gatctgtcag gacggcagga aagaaaacaa atcttcaaag 780 ggaaaacatt tatatttttg aatgccaaac agcataagaa attgagttcc gcagttgtct 840 ttggaggtgg ggaagctagg ttgataacag aagagaatga agaagaacat aatttctttt 900 tggctccggg aacgtgtgtt gttgatacag gaataacaaa ctcacagacc ttaattcctg 960 actgtcagaa gaaatggatt cagtcaataa tggatatgct ccaaaggcaa ggtcttagac 1020 ctattcctga agcagaaatt ggattggcgg tgattttcat gactacaaag aattactgtg 1080 atcctcaggg ccatcccagt acaggattaa agacaacaac tccaggacca agcctttcac 1140 aaggcgtgtc agttgatgaa aaactaatgc caagcgcccc agtgaacact acaacatacg 1200 tagctgacac agaatcagag caagcagata catgggattt gagtgaaagg ccaaaagaaa 1260 tcaaagtctc caaaatggaa caaaaattca gaatgctttc acaagatgca cccactgtaa 1320 aggagtcctg caaaacaagc tctaataata atagtatggt atcaaatact ttggctaaga 1380 tgagaatccc aaactatcag ctttcaccaa ctaaattgcc aagtataaat aaaagtaaag 1440 atagggcttc tcagcagcag cagaccaact ccatcagaaa ctactttcag ccgtctacca 1500 aaaaaaggga aagggatgaa gaaaatcaag aaatgtcttc atgcaaatca gcaagaatag 1560 aaacgtcttg ttctctttta gaacaaacac aacctgctac accctcattg tggaaaaata 1620 aggagcagca tctatctgag aatgagcctg tggacacaaa ctcagacaat aacttattta 1680 cagatacaga tttaaaatct attgtgaaaa attctgccag taaatctcat gctgcagaaa 1740 agctaagatc aaataaaaaa agggaaatgg atgatgtggc catagaagat gaagtattgg 1800 aacagttatt caaggacaca aaaccagagt tagaaattga tgtgaaagtt caaaaacagg 1860 aggaagatgt caatgttaga aaaaggccaa ggatggatat agaaacaaat gacactttca 1920 gtgatgaagc agtaccagaa agtagcaaaa tatctcaaga aaatgaaatt gggaagaaac 1980 gtgaactcaa ggaagactca ctatggtcag ctaaagaaat atctaacaat gacaaacttc 2040 aggatgatag tgagatgctt ccaaaaaagc tgttattgac tgaatttaga tcactggtga 2100 ttaaaaactc tacttccaga aatccatctg gcataaatga tgattatggt caactaaaaa 2160 atttcaagaa attcaaaaag gtcacatatc ctggagcagg aaaacttcca cacatcattg 2220 gaggatcaga tctaatagct catcatgctc gaaagaatac agaactagaa gagtggctaa 2280 ggcaggaaat ggaggtacaa aatcaacatg caaaagaaga gtctcttgct gatgatcttt 2340 ttagatacaa tccttattta aaaaggagaa gataactgag gattttaaaa agaagccatg 2400 gaaaaacttc ctagtaagca tctacttcag gccaacaagg ttatatgaat atatagtgta 2460 tagaagcgat ttaagttaca atgttttatg gcctaaattt attaaataaa atgcacaaaa 2520 ctttgattct tttgtatgta acaattgttt gttctgtttt caggctttgt cattgcatct 2580 ttttttcatt tttaaatgtg ttttgtttat taaatagtta atatagtcac agttcaaaat 2640 tctaaatgta cgtaaggtaa agactaaagt cacccttcca ccattgtcct agctacttgg 2700 ttcccctcag aaaaaaattc atgatactca tttcttatga atctttccag ggatttttga 2760 gtcctattca aattcctatt tttaaataat ttcctacaca aatgatagca taacatatgc 2820 agtgttctac accttgcttt tttacttagt agattaaaaa ttataggaat atcaatataa 2880 tgtttttaat attttttctt ttccattatg ctgtagtctt acctaaactc tggtgatcca 2940 aacaaaatgg cttcagtggt gcagatgtca cctacatgtt attctagtac tagaaactga 3000 agaccatgtg gagacttcat caaacatggg tttagttttc accagaatgg aaagacctgt 3060 accccttttt ggtggtctta ctgagctggg tgggtgtctg ttttgagctt atttagagtc 3120 ctagttttcc tacttataaa gtagaaatgg tgagattgtt ttctttttct accttaaagg 3180 gagatggtaa gaaacaatga atgtcttttt tcaaacttta ttgacaagtg attttcaagt 3240 ctgtgttcaa aaatatattc atgtacctgt gatccagcaa gaagggagtt ccagtcaaga 3300 gtcactacaa ctgattagtt gtttagagaa tgagaaatgg aacagtgagg aatggaggcc 3360 atatttccat gacttccctt gtaaacagaa gcaacagaag ggacaagagg ctggcctcta 3420 catcactctc accttccaaa tcttgtggaa gtgcatctac ttgccagaac caaattaact 3480 tacttccaag ttctggctgc ttgcaggtgg aactccagct gcaagggagt tagggaaatg 3540 aaggtctttt tttaaaagct tctcagcctt cctagggaac agaaattggg tgagccaatc 3600 tgcaatttct actacaggca ttgagaccag ttagattatt gaaatattat agagagttat 3660 gaacacttaa attatgatag tggtatgaca ttggatagaa catgggatac tttagaagta 3720 gaattgacag ggcatattag ttgatgaaat ggagtcattt gagtctctta atagccatgt 3780 atcataatta ccaagtgaag ctggtggaac atatggtctc cattttacag ttaaggaata 3840 taatggacag attaatattg ttctctgtca tgcccacaat ccctttctaa ggaagactgc 3900 cctactatag cagtttttat atttgtcaat ttatgaatat aatgaatgag agttctggta 3960 cctcctgtct ttacaaatat tggtgttgtc agtatttttc cctttttaac cattccaatc 4020 ggtgtgtagt gatgtttcat tttggtttta atttgtatat ccctgatagc tataattggg 4080 tcatagaaat tctttataca ttctagatgc aagtctcttg tcggatatat gtattgagat 4140 attacaccta gtctgtggct tgactgtttt ctttatgtct tttgatgaat agaagtttta 4200 aattttgaca aggtcaaatt tatttttttc ttttgtttga tattttttct ctccaattta 4260 accccaagat ttcagatatt ctgctctatt atataaactt tatattttta tatttgtgat 4320 ctaccttgaa ttgatatgta tgttgtgaat tatggatcag ggttcttttt ttcccccata 4380 caagtatcca gtcattgtaa cactgtttat tgaaagaatt atcctttcct cattaaatta 4440 ccttgccaat tagtaaaaaa tcaattaacc ataaaaaaaa aaaaaaaaag aaaaaaaaaa 4500 aaaaaa 4506 <210> 258 <211> 4412 <212> DNA <213> Homo sapiens <400> 258 agccccggtt acgcggttgc acgtcggccc cagccctgag gagccggacc gatgtggaaa 60 ctgctgcccg ccgcgggccc ggcaggagga gaaccataca gacttttgac tggcgttgag 120 tacgttgttg gaaggaaaaa ctgtgccatt ctgattgaaa atgatcagtc gatcagccga 180 aatcatgctg tgttaactgc taacttttct gtaaccaacc tgagtcaaac agatgaaatc 240 cctgtattga cattaaaaga taattctaag tatggtacct ttgttaatga ggaaaaaatg 300 cagaatggct tttcccgaac tttgaagtcg ggggatggta ttacttttgg agtgtttgga 360 agtaaattca gaatagagta tgagcctttg gttgcatgct cttcttgttt agatgtctct 420 gggaaaactg ctttaaatca agctatattg caacttggag gatttactgt aaacaattgg 480 acagaagaat gcactcacct tgtcatggta tcagtgaaag ttaccattaa aacaatatgt 540 gcactcattt gtggacgtcc aattgtaaag ccagaatatt ttactgaatt cctgaaagca 600 gttgagtcca agaagcagcc tccacaaatt gaaagttttt acccacctct tgatgaacca 660 tctattggaa gtaaaaatgt tgatctgtca ggacggcagg aaagaaaaca aatcttcaaa 720 gggaaaacat ttatattttt gaatgccaaa cagcataaga aattgagttc cgcagttgtc 780 tttggaggtg gggaagctag gttgataaca gaagagaatg aagaagaaca taatttcttt 840 ttggctccgg gaacgtgtgt tgttgataca ggaataacaa actcacagac cttaattcct 900 gactgtcaga agaaatggat tcagtcaata atggatatgc tccaaaggca aggtcttaga 960 cctattcctg aagcagaaat tggattggcg gtgattttca tgactacaaa gaattactgt 1020 gatcctcagg gccatcccag tacaggatta aagacaacaa ctccaggacc aagcctttca 1080 caaggcgtgt cagttgatga aaaactaatg ccaagcgccc cagtgaacac tacaacatac 1140 gtagctgaca cagaatcaga gcaagcagat acatgggatt tgagtgaaag gccaaaagaa 1200 atcaaagtct ccaaaatgga acaaaaattc agaatgcttt cacaagatgc acccactgta 1260 aaggagtcct gcaaaacaag ctctaataat aatagtatgg tatcaaatac tttggctaag 1320 atgagaatcc caaactatca gctttcacca actaaattgc caagtataaa taaaagtaaa 1380 gatagggctt ctcagcagca gcagaccaac tccatcagaa actactttca gccgtctacc 1440 aaaaaaaggg aaagggatga agaaaatcaa gaaatgtctt catgcaaatc agcaagaata 1500 gaaacgtctt gttctctttt agaacaaaca caacctgcta caccctcatt gtggaaaaat 1560 aaggagcagc atctatctga gaatgagcct gtggacacaa actcagacaa taacttattt 1620 acagatacag atttaaaatc tattgtgaaa aattctgcca gtaaatctca tgctgcagaa 1680 aagctaagat caaataaaaa aagggaaatg gatgatgtgg ccatagaaga tgaagtattg 1740 gaacagttat tcaaggacac aaaaccagag ttagaaattg atgtgaaagt tcaaaaacag 1800 gaggaagatg tcaatgttag aaaaaggcca aggatggata tagaaacaaa tgacactttc 1860 agtgatgaag cagtaccaga aagtagcaaa atatctcaag aaaatgaaat tgggaagaaa 1920 cgtgaactca aggaagactc actatggtca gctaaagaaa tatctaacaa tgacaaactt 1980 caggatgata gtgagatgct tccaaaaaag ctgttattga ctgaatttag atcactggtg 2040 attaaaaact ctacttccag aaatccatct ggcataaatg atgattatgg tcaactaaaa 2100 aatttcaaga aattcaaaaa ggtcacatat cctggagcag gaaaacttcc acacatcatt 2160 ggaggatcag atctaatagc tcatcatgct cgaaagaata cagaactaga agagtggcta 2220 aggcaggaaa tggaggtaca aaatcaacat gcaaaagaag agtctcttgc tgatgatctt 2280 tttagataca atccttattt aaaaaggaga agataactga ggattttaaa aagaagccat 2340 ggaaaaactt cctagtaagc atctacttca ggccaacaag gttatatgaa tatatagtgt 2400 atagaagcga tttaagttac aatgttttat ggcctaaatt tattaaataa aatgcacaaa 2460 actttgattc ttttgtatgt aacaattgtt tgttctgttt tcaggctttg tcattgcatc 2520 tttttttcat ttttaaatgt gttttgttta ttaaatagtt aatatagtca cagttcaaaa 2580 ttctaaatgt acgtaaggta aagactaaag tcacccttcc accattgtcc tagctacttg 2640 gttcccctca gaaaaaaatt catgatactc atttcttatg aatctttcca gggatttttg 2700 agtcctattc aaattcctat ttttaaataa tttcctacac aaatgatagc ataacatatg 2760 cagtgttcta caccttgctt ttttacttag tagattaaaa attataggaa tatcaatata 2820 atgtttttaa tattttttct tttccattat gctgtagtct tacctaaact ctggtgatcc 2880 aaacaaaatg gcttcagtgg tgcagatgtc acctacatgt tattctagta ctagaaactg 2940 aagaccatgt ggagacttca tcaaacatgg gtttagtttt caccagaatg gaaagacctg 3000 tacccctttt tggtggtctt actgagctgg gtgggtgtct gttttgagct tatttagagt 3060 cctagttttc ctacttataa agtagaaatg gtgagattgt tttctttttc taccttaaag 3120 ggagatggta agaaacaatg aatgtctttt ttcaaacttt attgacaagt gattttcaag 3180 tctgtgttca aaaatatatt catgtacctg tgatccagca agaagggagt tccagtcaag 3240 agtcactaca actgattagt tgtttagaga atgagaaatg gaacagtgag gaatggaggc 3300 catatttcca tgacttccct tgtaaacaga agcaacagaa gggacaagag gctggcctct 3360 acatcactct caccttccaa atcttgtgga agtgcatcta cttgccagaa ccaaattaac 3420 ttacttccaa gttctggctg cttgcaggtg gaactccagc tgcaagggag ttagggaaat 3480 gaaggtcttt ttttaaaagc ttctcagcct tcctagggaa cagaaattgg gtgagccaat 3540 ctgcaatttc tactacaggc attgagacca gttagattat tgaaatatta tagagagtta 3600 tgaacactta aattatgata gtggtatgac attggataga acatgggata ctttagaagt 3660 agaattgaca gggcatatta gttgatgaaa tggagtcatt tgagtctctt aatagccatg 3720 tatcataatt accaagtgaa gctggtggaa catatggtct ccattttaca gttaaggaat 3780 ataatggaca gattaatatt gttctctgtc atgcccacaa tccctttcta aggaagactg 3840 ccctactata gcagttttta tatttgtcaa tttatgaata taatgaatga gagttctggt 3900 acctcctgtc tttacaaata ttggtgttgt cagtattttt cctttttaac cattccaatc 3960 ggtgtgtagt gatgtttcat tttggtttta atttgtatat ccctgatagc tataattggg 4020 tcatagaaat tctttataca ttctagatgc aagtctcttg tcggatatat gtattgagat 4080 attacaccta gtctgtggct tgactgtttt ctttatgtct tttgatgaat agaagtttta 4140 aattttgaca aggtcaaatt tatttttttc ttttgtttga tattttttct ctccaattta 4200 accccaagat ttcagatatt ctgctctatt atataaactt tatattttta tatttgtgat 4260 ctaccttgaa ttgatatgta tgttgtgaat tatggatcag ggttcttttt ttcccccata 4320 caagtatcca gtcattgtaa cactgtttat tgaaagaatt atcctttcct cattaaatta 4380 ccttgccaat tagtaaaaaa tcaattaacc at 4412 <210> 259 <211> 4406 <212> DNA <213> Homo sapiens <400> 259 ttcggcacga ggcgcggttg cacgtcggcc ccagccctga ggagccggac cgatgtggaa 60 actgctgccc gccgcgggcc cggcaggagg agaaccatac agacttttga ctggcgttga 120 gtacgttgtt ggaaggaaaa actgtgccat tctaattgaa aatgatcagt cgatcagccg 180 aaatcatgct gtgttaactg ctaacttttc tgtaaccaac ctgagtcaaa cagatgaaat 240 ccctgtattg acattaaaag ataattctaa gtatggtacc tttgttaatg aggaaaaaat 300 gcagaatggc ttttcccgaa ctttgaagtc gggggatggt attacttttg gagtgtttgg 360 aagtaaattc agaatagagt atgagccttt ggttgcatgc tcttcttgtt tagatgtctc 420 tgggaaaact gctttaaatc aagctatatt gcaacttgga ggatttactg taaacaattg 480 gacagaagaa tgcactcacc ttgtcatggt atcagtgaaa gttaccatta aaacaatatg 540 tgcactcatt tgtggacgtc caattgtaaa gccagaatat tttactgaat tcctgaaagc 600 agttcagtcc aagaagcagc ctccacaaat tgaaagtttt tacccacctc ttgatgaacc 660 atctattgga agtaaaaatg ttgatctgtc aggacggcag gaaagaaaac aaatcttcaa 720 agggaaaaca tttatatttt tgaatgccaa acagcataag aaattgagtt ccgcagttgt 780 ctttggaggt ggggaagcta ggttgataac agaagagaat gaagaagaac ataatttctt 840 tttggctccg ggaacgtgtg ttgttgatac aggaataaca aactcacaga ccttaattcc 900 tgactgtcag aagaaatgga ttcagtcaat aatggatatg ctccaaaggc aaggtcttag 960 acctattcct gaagcagaaa ttggattggc ggtgattttc atgactacaa agaattactg 1020 tgatcctcag ggccatccca gtacaggatt aaagacaaca actccaggac caagcctttc 1080 acaaggcgtg tcagttgatg aaaaactaat gccaagcgcc ccagtgaaca ctacaacata 1140 cgtagctgac acagaatcag agcaagcaga tacatgggat ttgagtgaaa ggccaaaaga 1200 aatcaaagtc tccaaaatgg aacaaaaatt cagaatgctt tcacaagacg cacccactgt 1260 aaaggagtcc tgcaaaacaa gctctaataa taatagtatg gtatcaaata ctttggctaa 1320 gatgagaatc ccaaactatc agctttcacc aactaaattg ccaagtataa ataaaagtaa 1380 agatagggct tctcagcagc agcagaccaa ctccatcaga aactactttc agccgtctac 1440 caaaaaaagg gaaagggatg aagaaaatca agaaatgtct tcatgcaaat cagcaagaat 1500 agaaacgtct tgttctcttt tagaacaaac acaacctgct acaccctcat tgtggaaaaa 1560 taaggagcag catctatctg agaatgagcc tgtggacaca aactcagaca ataacttatt 1620 tacagataca gatttaaaat ctattgtgaa aaattctgcc agtaaatctc atgctgcaga 1680 aaagctaaga tcaaataaaa aaagggaaat ggatgatgtg gccatagaag atgaagtatt 1740 ggaacagtta ttcaaggaca caaaaccaga gttagaaatt gatgtgaaag ttcaaaaaca 1800 ggaggaagat gtcaatgtta gaaaaaggcc aaggatggat atagaaacaa atgacacttt 1860 cagtgatgaa gcagtaccag aaagtagcaa aatatctcaa gaaaatgaaa ttgggaagaa 1920 acgtgaactc aaggaagact cactatggtc agctaaagaa atatctaaca atgacaaact 1980 tcaggatgat agtgagatgc ttccaaaaaa gctgttattg actgaattta gatcactggt 2040 gattaaaaac tctacttcca gaaatccgtc tggcataaat gatgattatg gtcaactaaa 2100 aaatttcaag aaattcaaaa aggtcacata tcctggagca ggaaaacttc cacacatcat 2160 tggaggatca gatctaatag ctcatcatgc tcgaaagaat acagaactag aagagtggct 2220 aaggcaggaa atggaggtac aaaatcaaca tgcaaaagaa gagtctcttg ctgatgatct 2280 ttttagatac aatccttatt taaaaaggag aagataactg aggattttaa aaagaagcca 2340 tggaaaaact tcctagtaag catctacttc aggccaacaa ggttatatga atatatagtg 2400 tatagaagcg atttaagtta caatgtttta tggcctaaat ttattaaata aaatgcacaa 2460 aactttgatt cttttgtatg taacaattgt ttgttctgtt ttcaggcttt gtcattgcat 2520 ctttttttca tttttaaatg tgttttgttt attaaatagt taatatagtc acagttcaaa 2580 attctaaatg tacgtaaggt aaagactaaa gtcacccttc caccattgtc ctagctactt 2640 ggttcccctc agaaaaaaat tcatgatact catttcttat gaatctttcc agggattttt 2700 gagtcctatt caaattccta tttttaaata atttcctaca caaatgatag cataacatat 2760 gcagtgttct acaccttgct tttttactta gtagattaaa aattatagga atatcaatat 2820 aatgttttta atattttttc ttttccatta tgctgtagtc ttacctaaac tctggtgatc 2880 caaacaaaat ggcttcagtg gtgcagatgt cacctacatg ttattctagt actagaaact 2940 gaagaccatg tggagacttc atcaaacatg ggtttagttt tcaccagaat ggaaagacct 3000 gtaccccttt ttggtggtct tactgagctg ggtgggtgtc tgttttgagc ttatttagag 3060 tcctagtttt cctacttata aagtagaaat ggtgagattg ttttcttttt ctaccttaaa 3120 gggagatggt aagaaacaat gaatgtcttt tttcaaactt tattgacaag tgattttcaa 3180 gtctgtgttc aaaaatatat tcatgtacct gtgatccagc aagaagggag ttccagtcaa 3240 gagtcactac aactgattag ttgtttagag aatgagaaat ggaacagtga ggaatggagg 3300 ccatatttcc atgacttccc ttgtaaacag aagcaacaga agggacaaga ggctggcctc 3360 tacatcactc tcaccttcca aatcttgtgg aagtgcatct acttgccaga accaaattaa 3420 cttacttcca agttctggct gcttgcaggt ggaactccag ctgcaaggga gttagggaaa 3480 tgaaggtctt tttttaaaag cttctcagcc ttcctaggga acagaaattg ggtgagccaa 3540 tctgcaattt ctactacagg cattgagacc agttagatta ttgaaatatt atagagagtt 3600 atgaacactt aaattatgat agtggtatga cattggatag aacatgggat actttagaag 3660 tagaattgac agggcatatt agttgatgaa atggagtcat ttgagtctct taatagccat 3720 gtatcataat taccaagtga agctggtgga acatatggtc tccattttac agttaaggaa 3780 tataatggac agattaatat tgttctctgt catgcccaca atccctttct aaggaagact 3840 gccctactat agcagttttt atatttgtca atttatgaat ataatgaatg aggagttctg 3900 gtacctcctg tctttacaaa tattgggtgt tgtccagtat ttttcccttt ttaaccattc 3960 caatcggtgt gtagtgatgt ttcattttgg ttttaatttg tatatccctg atagctataa 4020 ttgggtcata gaaattcttt atacattcta gatgcaagtc tcttgtcgga tatatgtatt 4080 gagatattac acctagtctg tggcttgact gttttcttta tgtcttttga tgaatagaag 4140 ttttaaattt tgacaaggtc aaatttattt ttttcttttg tttgatattt tttctctcca 4200 atttaacccc aagatttcag atattctgct ctattatata aactttatat ttttatattt 4260 gtgatctacc ttgaattgat atgtatgttg tgaattatgg atcagggttc tttttttccc 4320 ccatacaagt atccagtcat tgtaacactg tttattgaaa gaattatcct ttcctcatta 4380 aattaccttg ccaattagtc tcgtgc 4406 <210> 260 <211> 4692 <212> DNA <213> Homo sapiens <400> 260 gagcgcgcac gtcccggagc ccatgccgac cgcaggcgcc gtatccgcgc tcgtctagca 60 gccccggtta cgcggttgca cgtcggcccc agccctgagg agccggaccg atgtggaaac 120 tgctgcccgc cgcgggcccg gcaggaggag aaccatacag acttttgact ggcgttgagt 180 acgttgttgg aaggaaaaac tgtgccattc tgattgaaaa tgatcagtcg atcagccgaa 240 atcatgctgt gttaactgct aacttttctg taaccaacct ggtatagaaa aacattttgg 300 aaatttctac agaaaaagta aaattgttac tagtcaaaca gatgaaatcc ctgtattgac 360 attaaaagat aattctaagt atggtacctt tgttaatgag gaaaaaatgc agaatggctt 420 ttcccgaact ttgaagtcgg gggatggtat tacttttgga gtgtttggaa gtaaattcag 480 aatagagtat gagcctttgg ttgcatgctc ttcttgttta gatgtctctg ggaaaactgc 540 tttaaatcaa gctatattgc aacttggagg atttactgta aacaattgga cagaagaatg 600 cactcacctt gtcatggtat cagtgaaagt taccattaaa acaatatgtg cactcatttg 660 tggacgtcca attgtaaagc cagaatattt tactgaattc ctgaaagcag ttgagtccaa 720 gaagcagcct ccacaaattg aaagttttta cccacctctt gatgaaccat ctattggaag 780 taaaaatgtt gatctgtcag gacggcagga aagaaaacaa atcttcaaag ggaaaacatt 840 tatatttttg aatgccaaac agcataagaa attgagttcc gcagttgtct ttggaggtgg 900 ggaagctagg ttgataacag aagagaatga agaagaacat aatttctttt tggctccggg 960 aacgtgtgtt gttgatacag gaataacaaa ctcacagacc ttaattcctg actgtcagaa 1020 gaaatggatt cagtcaataa tggatatgct ccaaaggcaa ggtcttagac ctattcctga 1080 agcagaaatt ggattggcgg tgattttcat gactacaaag aattactgtg atcctcaggg 1140 ccatcccagt acaggattaa agacaacaac tccaggacca agcctttcac aaggcgtgtc 1200 agttgatgaa aaactaatgc caagcgcccc agtgaacact acaacatacg tagctgacac 1260 agaatcagag caagcagata catgggattt gagtgaaagg ccaaaagaaa tcaaagtctc 1320 caaaatggaa caaaaattca gaatgctttc acaagatgca cccactgtaa aggagtcctg 1380 caaaacaagc tctaataata atagtatggt atcaaatact ttggctaaga tgagaatccc 1440 aaactatcag ctttcaccaa ctaaattgcc aagtataaat aaaagtaaag atagggcttc 1500 tcagcagcag cagaccaact ccatcagaaa ctactttcag ccgtctacca aaaaaaaggg 1560 aaagggatga agaaaatcaa gaaatgtctt catgcaaatc agcaagaata gaaacgtctt 1620 gttctctttt agaacaaaca caacctgcta caccctcatt gtggaaaaat aaggagcagc 1680 atctatctga gaatgagcct gtggacacaa actcagacaa taacttattt acagatacag 1740 atttaaaatc tattgtgaaa aattctgcca gtaaatctca tgctgcagaa aagctaagat 1800 caaataaaaa aagggaaatg gatgatgtgg ccatagaaga tgaagtattg gaacagttat 1860 tcaaggacac aaaaccagag ttagaaattg atgtgaaagt tcaaaaacag gaggaagatg 1920 tcaatgttag aaaaaggcca aggatggata tagaaacaaa tgacactttc agtgatgaag 1980 cagtaccaga aagtagcaaa atatctcaag aaaatgaaat tgggaagaaa cgtgaactca 2040 aggaagactc actatggtca gctaaagaaa tatctaacaa tgacaaactt caggatgata 2100 gtgagatgct tccaaaaaag ctgttattga ctgaatttag atcactggtg attaaaaact 2160 ctacttccag aaatccatct ggcataaatg atgattatgg tcaactaaaa aatttcaaga 2220 aattcaaaaa ggtcacatat cctggagcag gaaaacttcc acacatcatt ggaggatcag 2280 atctaatagc tcatcatgct cgaaagaata cagaactaga agagtggcta aggcaggaaa 2340 tggaggtaca aaatcaacat gcaaaagaag agtctcttgc tgatgatctt tttagataca 2400 atccttattt aaaaaggaga agataactga ggattttaaa aagaagccat ggaaaaactt 2460 cctagtaagc atctacttca ggccaacaag gttatatgaa tatatagtgt atagaagcga 2520 tttaagttac aatgttttat ggcctaaatt tattaaataa aatgcacaaa actttgattc 2580 ttttgtatgt aacaattgtt tgttctgttt tcaggctttg tcattgcatc tttttttcat 2640 ttttaaatgt gttttgttta ttaaatagtt aatatagtca cagttcaaaa ttctaaatgt 2700 acgtaaggta aagactaaag tcacccttcc accattgtcc tagctacttg gttcccctca 2760 gaaaaaaatt catgatactc atttcttatg aatctttcca gggatttttg agtcctattc 2820 aaattcctat ttttaaataa tttcctacac aaatgatagc ataacatatg cagtgttcta 2880 caccttgctt ttttacttag tagattaaaa attataggaa tatcaatata atgtttttaa 2940 tattttttct tttccattat gctgtagtct tacctaaact ctggtgatcc aaacaaaatg 3000 gcttcagtgg tgcagatgtc acctacatgt tattctagta ctagaaactg aagaccatgt 3060 ggagacttca tcaaacatgg gtttagtttt caccagaatg gaaagacctg tacccctttt 3120 tggtggtctt actgagctgg gtgggtgtct gttttgagct tatttagagt cctagttttc 3180 ctacttataa agtagaaatg gtgagattgt tttctttttc taccttaaag ggagatggta 3240 agaaacaatg aatgtctttt ttcaaacttt attgacaagt gattttcaag tctgtgttca 3300 aaaatatatt catgtacctg tgatccagca agaagggagt tccagtcaag agtcactaca 3360 actgattagt tgtttagaga atgagaaatg gaacagtgag gaatggaggc catatttcca 3420 tgacttccct tgtaaacaga agcaacagaa gggacaagag gctggcctct acatcactct 3480 caccttccaa atcttgtgga agtgcatcta cttgccagaa ccaaattaac ttacttccaa 3540 gttctggctg cttgcaggtg gaactccagc tgcaagggag ttagggaaat gaaggtcttt 3600 ttttaaaagc ttctcagcct tcctagggaa cagaaattgg gtgagccaat ctgcaatttc 3660 tactacaggc attgagacca gttagattat tgaaatatta tagagagtta tgaacactta 3720 aattatgata gtggtatgac attggataga acatgggata ctttagaagt agaattgaca 3780 gggcatatta gttgatgaaa tggagtcatt tgagtctctt aatagccatg tatcataatt 3840 accaagtgaa gctggtggaa catatggtct ccattttaca gttaaggaat ataatggaca 3900 gattaatatt gttctctgtc atgcccacaa tccctttcta aggaagactg ccctactata 3960 gcagttttta tatttgtcaa tttatgaata taatgaatga gagttctggt acctcctgtc 4020 tttacaaata ttggtgttgt cagtattttt cctttttaac cattccaatc ggtgtgtagt 4080 gatgtttcat tttggtttta atttgtatat ccctgatagc tataattggg tcatagaaat 4140 tctttataca ttctagatgc aagtctcttg tcggatatat gtattgagat attacaccta 4200 gtctgtggct tgactgtttt ctttatgtct tttgatgaat agaagtttta aattttgaca 4260 aggtcaaatt tatttttttc ttttgtttga tattttttct ctccaattta accccaagat 4320 ttcagatatt ctgctctatt atataaactt tatattttta tatttgtgat ctaccttgaa 4380 ttgatatgta tgttgtgaat tatggatcag ggttcttttt ttcccccata caagtatcca 4440 gtcattgtaa cactgtttat tgaaagaatt atcctttcct cattaaatta ccttgccaat 4500 tagtaaaaaa tcaattaacc ataatggtgg atctgtttct ggactttctg tttggttaca 4560 ctgaaatgtt tgtccatcct tgcactcact cataccatac tgccttgaat tactgtagct 4620 gcatagatgc tccttaagtt gggattacat tgtaataaac gcaatgtaag ttaaaaaaaa 4680 aaaaaaaaaa ca 4692 <210> 261 <211> 4550 <212> DNA <213> Homo sapiens <400> 261 gatcgcgcac gtcccggagc ccatgccgac cgcaggcgcc gtatccgcgc tcgtctagca 60 gccccggtta cgcggttgca cgtcggcccc agccctgagg agccggaccg atgtggaaac 120 tgctgcccgc cgcgggcccg gcaggaggag aaccatacag acttttgact ggcgttgagt 180 acgttgttgg aaggaaaaac tgtgccattc tgattgaaaa tgatcagtcg atcagccgaa 240 atcatgctgt gttaactgct aacttttctg taaccaacct ggtatagaaa aacattttgg 300 aaatttctac agaaaaagta aaattgttac tagtcaaaca gatgaaatcc ctgtattgac 360 attaaaagat aattctaagt atggtacctt tgttaatgag gaaaaaatgc agaatggctt 420 ttcccgaact ttgaagtcgg gggatggtat tacttttgga gtgtttggaa gtaaattcag 480 aatagagtat gagcctttgg ttgcatgctc ttcttgttta gatgtctctg ggaaaactgc 540 tttaaatcaa gctatattgc aacttggagg atttactgta aacaattgga cagaagaatg 600 cactcacctt gtcatggtat cagtgaaagt taccattaaa acaatatgtg cactcatttg 660 tggacgtcca attgtaaagc cagaatattt tactgaattc ctgaaagcag ttgagtccaa 720 gaagcagcct ccacaaattg aaagttttta cccacctctt gatgaaccat ctattggaag 780 taaaaatgtt gatctgtcag gacggcagga aagaaaacaa atcttcaaag ggaaaacatt 840 tatatttttg aatgccaaac agcataagaa attgagttcc gcagttgtct ttggaggtgg 900 ggaagctagg ttgataacag aagagaatga agaagaacat gatttctttt tggctccggg 960 aacgtgtgtt gttgatacag gaataacaaa ctcacagacc ttaattcctg actgtcagaa 1020 gaaatggatt cagtcaataa tggatatgct ccaaaggcaa ggtcttagac ctattcctga 1080 agcaaattgg attggcggtg attttcatga ctacaaagaa ttactgtgat cctcagggcc 1140 atcccagtac aggattaaag acaacaactc caggaccaag cctttcacaa ggcgtgtcag 1200 ttgatgaaaa actaatgcca agcgccccag tgaacactac aacatacgta gctgacacag 1260 aatcagagca agcagataca tgggatttga gtgaaaggcc aaaagaaatc aaagtctcca 1320 aaatggaaca aaaattcaga atgctttcac aagatgcacc cactgtaaag gagtcctgca 1380 aaacaagctc taataataat agtatggtat caaatacttt ggctaagatg agaatcccaa 1440 actatcagct ttcaccaact aaattgccaa gtataaataa aagtaaagat agggcttctc 1500 agcagcagca gaccaactcc atcagaaact actttcagcc gtctaccaaa aaaagggaaa 1560 gggatgaaga aaatcaagaa atgtcttcat gcaaatcagc aagaatagaa acgtcttgtt 1620 ctcttttaga acaaacacaa cctgctacac cctcattgtg gaaaaataag cagcatctat 1680 ctgagaatga gcctgtggac acaaactcag acaataactt atttacagat acagatttaa 1740 aatctattgt gaaaaattct gccagtaaat ctcatgctgc agaaaagcta agatcaaata 1800 aaaaaaggga aatggatgat gtggccatag aagatgaagt attggaacag ttattcaagg 1860 acacaaaacc agagttagaa attgatgtga aagttcaaaa acaggaggaa gatgtcaatg 1920 ttagaaaaag gccaaggatg gatatagaaa caaatgacac tttcagtgat gaagcagtac 1980 cagaaagtag cgaaatatct caagaaaatg aaattgggaa gaaacgtgaa ctcaaggaag 2040 actcactatg gtcagctaaa gaaatatcta acaatgacaa acttcaggat gatagtgaga 2100 tgcttccaaa aaagctgtta ttgactgaat ttagatcact ggtgattaaa aactctactt 2160 ccagaaatcc atctggcata aatgatgatt atggtcaact aaaaaatttc aagaaattca 2220 aaaaggtcac atatcctgga gcaggaaaac ttccacacat cattggagga tcagatctaa 2280 tagctcatca tgctcgaaag aatacagaac tagaagagtg gctaaggcag gaaatggagg 2340 tacaaaatca acatgcaaaa gaagagtctc ttgctgatga tctttttaga tacaatcctt 2400 atttaaaaag gagaagataa ctgaggattt taaaaagaag ccatggaaaa acttcctagt 2460 aagcatctac ttcaggccga caaggttata tgaatatata gtgtatagaa gcgatttaag 2520 ttacaatgtt ttatggccta aatttattaa ataaaatgca caaaactttg attcttttgt 2580 atgtaacaat tgtttgttct gttttcaggc tttgtcattg catctttttt tcatttttaa 2640 atgtgttttg tttattaaat agttaatata gtcacagttc aaaattctaa atatacgtaa 2700 ggtaaagact aaagtcaccc ttccaccatt gtcctagcta cttggttccc ctcagaaaaa 2760 aattcatgat actcatttct tatgaatctt tccagggatt tttgagtcct attcaaattc 2820 ctatttttaa ataatttcct acacaaatga tagcataaca tatgcagtgt tctacacctt 2880 gcttttttac ttagtagatt aaaaattata ggaatatcaa tataatgttt ttaatatttt 2940 ttcttttcca ttatgctgta ctcttaccta aactctggtg atccaaacaa aatggcttca 3000 gtggtgcaga tgtcacctac atgttattct agtactagaa actgaagacc atgtggatac 3060 ttcatcaaac atgggtttag ttttcaccag aatggaaaga cctgtacccc tttttggtgg 3120 tcttactgag ctgggtgggt gtctgttttg agcttattta gagtcctagt tttcctactt 3180 ataaagtaga aatggtgaga ttgttttctt tttctacctt aaagggagat ggtaagaaac 3240 aatgaatgtc ttttttcaaa ctttattgac aagtgatttt caagtctgtg ttcaaaaata 3300 tattcatgta cctgtgatcc agcaagaagg gagttccagt caagagtcac tacaactgat 3360 tagttgttta gagaatgaga aatggaacag tgaggaatgg aggccatatt tccatgactt 3420 cccttgtaaa cagaagcaac agaagggaca agaggctggc ctctacatca ctctcacctt 3480 ccaaatcttg tggaagtgca tctacttgcc agaaccaaat taacttactt ccaagttctg 3540 gctgcttgca ggtggaactc cagctgcaag ggagttaggg aaatgaaggt ctttttttaa 3600 aagcttctca gccttcctag ggaacagaca ttgggtgagc caatctgcaa tttctactac 3660 aggcattgag accagttaga ttattgaaat attatagaga gttatgaaca cttaaattat 3720 gatagtggta tgacattgga tagaacatgg gatactttag aagtagaatt gacagggcat 3780 attagttgat gaaatggagt catttgagtc tcttaatagc catgtatcat aattaccaag 3840 tgaagctggt ggaacatatg gtctccattt tacagttaag gaatataatg gacagattaa 3900 tattgttctc tgtcgtgccc acaatccctt tctaaggaag actgccctac tatagcagtt 3960 tttatatttg tcaatttatg aatataatga atgagagttc tggtacctcc tgtctttaca 4020 aatattggtg ttgtcagtat ttttcctttt taaccattcc aatcggtgtg tagtgatgtt 4080 tcattttggt tttaatttgt atatccctga tagctataat tgggtcatag aaattcttta 4140 tacattctag atgcaagtct cttgtcggat atacgtattg agatattaca cctagtctgt 4200 ggcttgactg ttttctttat gtcttttgat gaatagaagt tttaaatttt gacaaggtca 4260 aatttatttt tttcttttgt ttgatatttt ttctctccaa tttaacccca agatttcaga 4320 tattctgctc tattatataa actttatatt tttatatttg tgatctacct tgaattgata 4380 tgtatgttgt gaattatgga tcagggttct ttttttcccc catacaagta tccagtcatt 4440 gtaacactgt ttattgaaag aattatcctt tcctcattaa attaccttgc caattagtaa 4500 aaaatcaatt aaccataaaa aaaaaaaaaa aaagaaaaaa aaaaaaaaaa 4550 <210> 262 <211> 1497 <212> DNA <213> Homo sapiens <400> 262 gacgtcggcc ccagccctga ggagccggac cgatgtggaa actgctgccc gccgcgggcc 60 cggcaggagg agaaccatac agacttttga ctggcgttga gtacgttgtt ggaaggaaaa 120 actgtgccat tctaattgaa aatgatcagt cgatcagccg aaatcatgct gtgttaactg 180 ctaacttttc tgtaaccaac ctgagtcaaa cagatgaaat ccctgtattg acattaaaag 240 ataattctaa gtatggtacc tttgttaatg aggaaaaaat gcagaatggc ttttcccgaa 300 ctttgaagtc gggggatggt attacttttg gagtgtttgg aagtaaattc agaatagagt 360 atgagccttt ggttgcatgc tcttcttgtt tagatgtctc tgggaaaact gctttaaatc 420 aagctatatt gcaacttgga ggatttactg taaacaattg gacagaagaa tgcactcacc 480 ttgtcatggt atcagtgaaa gttaccatta aaacaatatg tgcactcatt tgtgggcgtc 540 caattgtaaa gccagaatat tttactgaat tcctgaaagc agttcagtcc aagaagcagc 600 ctccacaaat tgaaagtttt tacccacctc ttgatgaacc atctattgga agtaaaaatg 660 ttgatctgtc aggacggcag gaaagaaaac aaatcttcaa agggaaaaca tttatatttt 720 tgaatgccaa acagcataag aaattgagtt ccgcagttgt ctttggaggt ggggaagcta 780 ggttgataac agaagagaat gaagaagaac ataatttctt tttggctccg ggaacgtgtg 840 ttgttgatac aggaataaca aactcacaga ccttaattcc tgactgtcag aagaaatgga 900 ttcagtcaat aatggatatg ctccaaaggc aaggtcttag acctattcct gaagcagaaa 960 ttggattggc ggtgattttc atgactacaa agaattactg tgatcctcag ggccatccca 1020 gtacaggatt aaagacaaca actccaggac caagcctttc acaaggcgtg tcagttgatg 1080 aaaaactaat gccaagcgcc ccagtgaaca ctacaacata cgtagctgac acagaatcag 1140 agcaagcaga tacatgggat ttgagtgaaa ggccaaaaga aatcaaagtc tccaaaatgg 1200 aacaaaaatt cagaatgctt tcacaagacg cacccactgt aaaggagtcc tgcaaaacaa 1260 gctctaataa taatagtatg gtatcaaata ctttggctaa gatgagaatc ccaaactatc 1320 agctttcacc aactaaattg ccaagtataa ataaaagtaa agatagggct tctcagcagc 1380 agcagaccaa ctccatcaga aactactttc agccgtctac caaaaaaaag ggaaagggat 1440 gaagaaaatc aagaaatgtc ttcatgcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa 1497 <210> 263 <211> 1460 <212> DNA <213> Homo sapiens <400> 263 ggggagccct gaggagccgg accgatgtgg aaactgctgc ccgccgcggg cccggcagga 60 ggagaaccat acagactttt gactggcgtt gagtacgttg ttggaaggaa aaactgtgcc 120 attctgattg aaaatgatca gtcgatcagc cgaaatcatg ctgtgttaac tgctaacttt 180 tctgtaacca acctgagtca aacagatgaa atccctgtat tgacattaaa agataattct 240 aagtatggta cctttgttaa tgaggaaaaa atgcagaatg gcttttcccg aactttgaag 300 tcgggggatg gtattacttt tggagtgttt ggaagtaaat tcagaataga gtatgagcct 360 ttggttgcat gctcttcttg tttagatgtc tctgggaaaa ctgctttaaa tcaagctata 420 ttgcaacttg gaggatttac tgtaaacaat tggacagaag aatgcactca ccttgtcatg 480 gtatcagtga aagttaccat taaaacaata tgtgcactca tttgtggacg tccaattgta 540 aagccagaat attttactga attcctgaaa gcagttgagt ccaagaagca gcctccacaa 600 attgaaagtt tttacccacc tcttgatgaa ccatctattg gaagtaaaaa tgttgatctg 660 tcaggacggc aggaaagaaa acaaatcttc aaagggaaaa catttatatt tttgaatgcc 720 aaacagcata agaaattgag ttccgcagtt gtctttggag gtggggaagc taggttgata 780 acagaagaga atgaagaaga acataatttc tttttggctc cgggaacgtg tgttgttgat 840 acaggaataa caaactcaca gaccttaatt cctgactgtc agaagaaatg gattcagtca 900 ataatggata tgctccaaag gcaaggtctt agacctattc ctgaagcaga aattggattg 960 gcggtgattt tcatgactac aaagaattac tgtgatcctc agggccatcc cagtacagga 1020 ttaaagacaa caactccagg accaagcctt tcacaaggcg tgtcagttga tgaaaaacta 1080 atgccaagcg ccccagtgaa cactacaaca tacgtagctg acacagaatc agagcaagca 1140 gatacatggg atttgagtga aaggccaaaa gaaatcaaag tctccaaaat ggaacaaaaa 1200 ttcagaatgc tttcacaaga tgcacccact gtaaaggagt cctgcaaaac aagctctaat 1260 aataatagta tggtatcaaa tactttggct aagatgagaa tcccaaacta tcagctttca 1320 ccaactaaat tgccaagtat aaataaaagt aaagataggg cttctaagca gcagcagacc 1380 aactccatca gaaactactt tcagccgtct accaaaaaaa gggaaaggga aaaaaaaaaa 1440 aaaaaaaaaa aaaaaaaaaa 1460 <210> 264 <211> 2044 <212> DNA <213> Homo sapiens <400> 264 gcgcacgtcc cggagcccat gccgaccgca ggcgccgtat ccgcgctcgt ctagcagccc 60 cggttacgcg gttgcacgtc ggccccagcc ctgaggagcc ggaccgatgt ggaaactgct 120 gcccgccgcg ggcccggcag gaggagaacc atacagactt ttgactggcg ttgagtacgt 180 tgttggaagg aaaaactgtg ccattctaat tgaaaatgat cagtcgatca gccgaaatca 240 tgctgtgtta actgctaact tttctgtaac caacctgagt caaacagatg aaatccctgt 300 attgacatta aaagataatt ctaagtatgg tacctttgtt aatgaggaaa aaatgcagaa 360 tggcttttcc cgaactttga agtcggggga tggtattact tttggagtgt ttggaagtaa 420 attcagaata gagtatgagc ctttggttgc atgctcttct tgtttagatg tctctgggaa 480 aactgcttta aatcaagcta tattgcaact tggaggattt actgtaaaca attggacaga 540 agaatgcact caccttgtca tggtatcagt gaaagttacc attaaaacaa tatgtgcact 600 catttgtgga cgtccaattg taaagccaga atattttact gaattcctga aagcagttca 660 gtccaagaag cagcctccac aaattgaaag tttttaccca cctcttgatg aaccatctat 720 tggaagtaaa aatgttgatc tgtcaggacg gcaggaaaga aaacaaatct tcaaagggaa 780 aacatttata tttttgaatg ccaaacagca taagaaattg agttccgcag ttgtctttgg 840 aggtggggaa gctaggttga taacagaaga gaatgaagaa gaacataatt tctttttggc 900 tccgggaacg tgtgttgttg atacaggaat aacaaactca cagaccttaa ttcctgactg 960 tcagaagaaa tggattcagt caataatgga tatgctccaa aggcaaggtc ttagacctat 1020 tcctgaagca gaaattggat tggcggtgat tttcatgact acaaagaatt actgtgatcc 1080 tcagggccat cccagtacag gattaaagac aacaactcca ggaccaagcc tttcacaagg 1140 cgtgtcagtt gatgaaaaac taatgccaag cgccccagtg aacactacaa catacgtagc 1200 tgacacagaa tcagagcaag cagatacatg ggatttgagt gaaaggccaa aagaaatcaa 1260 agtctccaaa atggaacaaa aacaccaact aaattgccaa gtataaataa aagtaaagat 1320 agggcttctc agcagcagca gaccaactcc atcagaaact actttcagcc gtctaccaaa 1380 aaaaagggaa agggatgaag aaaatcaaga aatgtcttca tgcaaatcag caagaataga 1440 aacgtcttgt tctcttttag aacaaacaca acctgctaca ccctcattgt ggaaaaataa 1500 ggagcagcat ctatctgaga atgagcctgt ggacacaaac tcagacaata acttatttac 1560 agatacagat ttaaaatcta ttgtgaaaaa ttctgccagt aaatctcatg ctgcagaaaa 1620 gctaagatca aataaaaaaa gggaaatgga tgatgtggcc atagaagatg aagtattgga 1680 acagttattc aaggacacaa aaccagagtt agaaattgat gtgaaagttc aaaaacagga 1740 ggaagatgtc aatgttagaa aaaggccaag gatggatata gaaacaaatg acactttcag 1800 tgatgaagca gtaccagaaa gtagcaaaat atctcaagaa aatgaaattg ggaagaaacg 1860 tgaactcaag gaagactcac tatggtcagc taaagaaata tctaacaatg gcaaacttca 1920 ggatgatagt gagatgcttc caaaaaagct gttattgact gaatttagat cactggtgat 1980 taaaaactct acttccagaa atccgtctgg cataaatgat gattatggtc aactaaaaaa 2040 tttc 2044 <210> 265 <211> 2143 <212> DNA <213> Homo sapiens <400> 265 ggtaagagtc gcgtagcccg agccgggcgg aaccactgtt cgcgctgccg tgtttccggg 60 cggggacact cagggcgcga cgcttttctg ttacccacag aggcccgccg cggctgcgcc 120 atccgcggcc atgaagtttc gggccaagat cgtggacggg gcctgtctga accacttcac 180 acgaatcagt aacatgatag ccaagcttgc caaaacctgc accctccgca tcagccctga 240 taagcttaac ttcatccttt gtgacaagct ggctaatgga ggagtgagca tgtggtgtga 300 gctggaacag gagaacttct tcaacgaatt tcaaatggag ggtgtctctg cagaaaacaa 360 tgagatttat ttagagctaa catcggaaaa cttatctcga gccttgaaga ctgcccagaa 420 tgccagggct ttgaaaatca aactgactaa taaacacttt ccctgcctca cggtctccgt 480 ggagctgtta tctatgtcaa gcagtagccg cattgtgacc catgacatcc ccataaaggt 540 gattcctagg aaattgtgga aggacttaca agaaccggtg gtcccagatc ctgatgttag 600 tatttattta ccagtcttga agactatgaa gagtgttgtg gaaaaaatga aaaacatcag 660 caatcacctt gttattgaag caaacctaga tggagaattg aatttgaaaa tagaaactga 720 attagtatgt gttacaactc attttaaaga tcttggaaat cctccattag cctctgaaag 780 cacccatgag gacagaaacg tggaacacat ggctgaagtg cacatagata ttaggaagct 840 cctacagttt cttgctggac aacaagtaaa tcccacaaag gccttatgca atattgtgaa 900 taacaagatg gtgcattttg atctgcttca tgaagacgtg tcccttcagt atttcatccc 960 tgcgctgtcc tagcaccctg tcgctggagt tggcatgcag agactttgtc aggatgggag 1020 aggccgcagg tgttgtgttc tgatcactgg tctgtgccct cacagcaccg cacatcgaca 1080 cactgtactt atttgtccct ctctaacatt ttaactaaaa gttgattcaa caacacacag 1140 ttggataaac atatcacttc atgttgctca tgtctgtttt gctttgtttt taagacactg 1200 aaaagaaaag ctagaattta tttattcaga ctttaaagaa caatttctca ttgatgttgt 1260 gaaaatcgtc atgtatttag acttggtgta gtagccagaa ttcgtaaagc tgttgcctgg 1320 gagcttggta ctttccctcc aggcagaggc tctagctcag cacggcctgt agcgcacagt 1380 cagtcttgca tttcagtgtg ttcaccccgc tgctcctgcc ccttggagcc cagtgacaga 1440 aagaacagcc tctgtcaccc cgccgccact gccttggtta ctcagagcac tgtggggtgt 1500 cacagctgca gcatttggag tctctctctt gctgaggact caagcccacc tgagtccact 1560 cccctcttga tgcctagaga gctggcccag ccaacacagc tcttagctgg gagctccttc 1620 tgccattcca actagtttct tcctggggcc agttttgggt ttaggttgta attccttata 1680 tttctttctt ccacagtgta tcggatctgt cgttctggaa agaagaccct tctatttaga 1740 gtagaaacaa acgaaacttc taaggtatca tctgtgttaa gtgatgagac catatttctt 1800 tgatgtttct gaacatcaaa gctgattcag tactggtaga tgtgctcatt ctccctgaaa 1860 catacccatc atatttccta ttataattac atctcattgt cctgtggagg tggacatgat 1920 aaacattatc ttttgttttc ttgttttgtt ttgtttgaga cggtctcatt ctgtcaccca 1980 gactggagtg cagtgccaca atcatggctc accgcattga cctccttggc tcaaggcatc 2040 ctcccacctc agcttcctga ctagctggga ctactggtgt gcaccaccac acccagctaa 2100 ttttcaattt ttcatagaga cagggtctca ctgtgttgtc cag 2143 <210> 266 <211> 1102 <212> DNA <213> Homo sapiens <400> 266 gccgcggctg cgccatccgc ggccatgaag tttcgggcca agatcgtgga cggggcctgt 60 ctgaaccact tcacacgaat cagtaacatg atagccaagc ttgccaaaac ctgcaccctc 120 cgcatcagcc ctgataagct taacttcatc ctttgtgaca agctggctaa tggaggagtg 180 agcatgtggt gtgagctgga acaggagaac ttcttcaacg aatttcaaat ggagggtgtc 240 tctgcagaaa acaatgagat ttatttagag ctaacatcgg aaaacttatc tcgagccttg 300 aagactgccc agaatgccag ggctttgaaa atcaaactga ctaataaaca ctttccctgc 360 ctcacggtct ccgtggagct gttatctatg tcaagcagta gccgcattgt gacccatgac 420 atccccataa aggtgattcc taggaaattg tggaaggact tacaagaacc ggtggtccca 480 gatcctgatg ttagtattta tttaccagtc ttgaagacta tgaagagtgt tgtggaaaaa 540 atgaaaaaca tcagcaatca ccttgttatt gaagcaaacc tagatggaga attgaatttg 600 aaaatagaaa ctgaattagt atgtgttaca actcatttta aagatcttgg aaatcctcca 660 ttagcctctg aaagcaccca tgaggacaga aacgtggaac acatggctga agtgcacata 720 gatattagga agctcctaca gtttcttgct ggacaacaag taaatcccac aaaggcctta 780 tgcaatattg tgaataacaa gatggtgcat tttgatctgc ttcatgaaga cgtgtccctt 840 cagtatttca tccctgcgct gtcctagcac cctgtcgctg gagttggcat gcagagactt 900 tgtcaggatg ggagaggccg caggtgttgt gttctgatca ctggtctgtg ccctcacagc 960 accgcacatc gacacactgt acttatttgt ccctctctaa cattttaact aaaagttgat 1020 tcaacaacac acagttggat aaacatatca cttcatgtta aaaaaaaaaa ataaaaaaaa 1080 aaaaaaaaaa aaaaaaaaaa aa 1102 <210> 267 <211> 2122 <212> DNA <213> Homo sapiens <400> 267 ctcagggcgc gaccttttct gttaccaaca gaggcccgcc gcggctgcgc catccgcggc 60 atgaagtttc gggccaagat cgtggacggg gcctgtctga accacttcac acgaatcagt 120 aacatgatag ccaagcttgc caaaacctgc accctccgca tcagccctga taagcttaac 180 ttcatccttt gtgacaagct ggctaatgga ggagtgagca tgtggtgtga gctggaacag 240 gagaacttct tcaacgaatt tcaaatggag ggtgtctctg cagaaaacaa tgagatttat 300 ttagagctaa catcggaaaa cttatctcga gccttgaaga ctgcccagaa tgccagggct 360 ttgaaaatca aactgactaa taaacacttt ccctgcctca cggtctccgt ggagctgtta 420 tctatgtcaa gcagtagccg cattgtgacc catgacatcc ccataaaggt gattcctagg 480 aaattgtgga aggacttaca agaaccggtg gtcccagatc ctgatgttag tatttattta 540 ccagtcttga agactatgaa gagtgttgtg gaaaaaatga aaaacatcag caatcacctt 600 gttattgaag caaacctaga tggagaattg aatttgaaaa tagaaactga attagtatgt 660 gttacaactc attttaaaga tcttggaaat cctccattag cctctgaaag cacccatgag 720 gacagaaacg tggaacacat ggctgaagtg cacatagata ttaggaagct cctacagttt 780 cttgctggac aacaagtaaa tcccacaaag gccttatgca atattgtgaa taacaagatg 840 gtgcattttg atctgcttca tgaagacgtg tcccttcagt atttcatccc tgcactgtcc 900 tagcaccctg tcgctggagt tggcatgcag agactttgtc aggatgggag aggccgcagg 960 tgttgtgttc tgatcactgg tctgtgccct cacagcaccg cacatcgaca cactgtactt 1020 atttgtccct ctctaacatt ttaactaaaa gttgattcaa caacacacag ttggataaac 1080 atatcacttc atgttgctca tgtctgtttt gctttgtttt taagacactg aaaagaaaag 1140 ctagaattta tttattcaga ctttaaagaa caatttctca ttgatgttgt gaaaatcgtc 1200 atgtatttag acttggtgta gtagccagaa ttcgtaaagc tgttgcctgg gagcttggta 1260 ctttccctcc aggcagaggc tctagctcag cacggcctgt agcgcacagt cagtcttgca 1320 tttcagtgtg ttcaccccgc tgctcctgcc ccttggagcc cagtgacaga aagaacagcc 1380 tctgtcaccc cgccgccact gccttggtta ctcagagcac tgtggggtgt cacagctgca 1440 gcatttggag tctctctctt gctgaggact caagcccacc tgagtccact cccctcttga 1500 tgcctagaga gctggcccag ccaacacagc tcttagctgg gagctccttc tgccattcca 1560 actagtttct tcctggggcc agttttgggt ttaggttgta attccttata tttctttctt 1620 ccacagtgta tcggatctgt cgttctggaa agaagaccct tctatttaga gtagaaacaa 1680 acgaaacttc taaggtatca tctgtgttaa gtgatgagac catatttctt tgatgtttct 1740 gaacatcaaa gctgattcag tactggtaga tgtgctcatt ctccctgaaa catacccatc 1800 atattgtcct attataatta catctcattg tcctgtggag gtggacatga taaacattat 1860 cttttgtttt cttgttttgt tttgtttgag acggtctcat tctgtcaccc agactggagt 1920 gcagtgccac aatcatggct caccgcattg acctccttgg ctcaaggcat cctcccacct 1980 cagcttcctg actagctggg actactggtg tgcaccacca cacccagcta attttcaatt 2040 tttcatagag acagggtctc actgtgttgt ccaggagttg gagaccagcc cgggcaacaa 2100 agtgagaccc cgtctctact tt 2122 <210> 268 <211> 2124 <212> DNA <213> Homo sapiens <400> 268 gctcagggcg cgacgctttt ctgttaccaa cagaggcccg ccgcggctgc gccatccgcg 60 gccatgaagt ttcgggccaa gatcgtggac ggggcctgtc tgaaccactt cacacgaatc 120 agtaacatga tagccaagct tgccaaaacc tgcaccctcc gcatcagccc tgataagctt 180 aacttcatcc tttgtgacaa gctggctaat ggaggagtga gcatgtggtg tgagctggaa 240 caggagaact tcttcaacga atttcaaatg gagggtgtct ctgcagaaaa caatgagatt 300 tatttagagc taacatcgga aaacttatct cgagccttga agactgccca gaatgccagg 360 gctttgaaaa tcaaactgac taataaacac tttccctgcc tcacggtctc cgtggagctg 420 ttatctatgt caagcagtag ccgcattgtg acccatgaca tccccataaa ggtgattcct 480 aggaaattgt ggaaggactt acaagaaccg gtggtcccag atcctgatgt tagtatttat 540 ttaccagtct tgaagactat gaagagtgtt gtggaaaaaa tgaaaaacat cagcaatcac 600 cttgttattg aagcaaacct agatggagaa ttgaatttga aaatagaaac tgaattagta 660 tgtgttacaa ctcattttaa agatcttgga aatcctccat tagcctctga aagcacccat 720 gaggacagaa acgtggaaca catggctgaa gtgcacatag atattaggaa gctcctacag 780 tttcttgctg gacaacaagt aaatcccaca aaggccttat gcaatattgt gaataacaag 840 atggtgcatt ttgatctgct tcatgaagac gtgtcccttc agtatttcat ccctgcgctg 900 tcctagcacc ctgtcgctgg agttggcatg cagagacttt gtcaggatgg gagagccgca 960 ggtgttgtgt tctgatcact ggtctgtgcc ctcacagcac cgcacatcga cacactgtac 1020 ttatttgtcc ctctctaaca ttttaactaa aagttgattc aacaacacac agttggataa 1080 acatatcact tcatgttgct catgtctgtt ttgctttgtt tttaagacac tgaaaagaaa 1140 agctagaatt tatttattca gactttaaag aacaatttct cattgatgtt gtgaaaatcg 1200 tcatgtattt agacttggtg tagtagccag aattcgtaaa gctgttgcct gggagcttgg 1260 tactttccct ccaggcagag gctctagctc agcacggcct gtagcgcaca gtcagtcttg 1320 catttcagtg tgttcacccc gctgctcctg ccccttggag cccagtgaca gaaagaacag 1380 cctctgtcac cccgccgcca ctgccttggt tactcagagc actgtggggt gtcacagctg 1440 cagcatttgg agtctctctc ttgctgagga ctcaagccca cctgagtcca ctcccctctt 1500 gatgcctaga gagctggccc agccaacaca gctcttagct gggagctcct tctgccattc 1560 caactagttt cttcctgggg ccagttttgg gtttaggttg taattcctta tatttctttc 1620 ttccacagtg tatcggatct gtcgttctgg aaagaagacc cttctattta gagtagaaac 1680 aaacgaaact tctaaggtat catctgtgtt aagtgatgag accatatttc tttgatgttt 1740 ctgaacatca aagctgattc agtactggta gatgtgctca ttctccctga aacataccca 1800 tcatatttcc tattataatt acatctcatt gtcctgtgga ggtggacatg ataaacatta 1860 tcttttgttt tcttgttttg ttttgtttga gacggtctca ttctgtcacc cagactggag 1920 tgcagtgcca caatcatggc tcaccgcatt gacctccttg gctcaaggca tcctcccacc 1980 tcagcttcct gactagctgg gactactggt gtgcaccacc acacccagct aattttcaat 2040 ttttcataga gacagggtct cactgtgttg tccaggagtt ggagaccagc ccgggcaaca 2100 aagtgagacc cccgtctcta cttt 2124 <210> 269 <211> 843 <212> DNA <213> Homo sapiens <400> 269 atgaagtttc gggccaagat cgtggacggg gcctgtctga accacttcac acgaatcagt 60 aacatgatag ccaagcttgc caaaacctgc accctccgca tcagccctga taagcttaac 120 ttcatccttt gtgacaagct ggctaatgga ggagtgagca tgtggtgtga gctggaacag 180 gagaacttct tcaacgaatt tcaaatggag ggtgtctctg cagaaaacaa tgagatttat 240 ttagagctaa catcggaaaa cttatctcga gccttgaaga ctgcccagaa tgccagggct 300 ttgaaaatca aactgactaa taaacacttt ccctgcctca cggtctccgt ggagctgtta 360 tctatgtcaa gcagtagccg cattgtgacc catgacatcc ccataaaggt gattcctagg 420 aaattgtgga aggacttaca agaaccggtg gtcccagatc ctgatgttag tatttattta 480 ccagtcttga agactatgaa gagtgttgtg gaaaaaatga aaaacatcag caatcacctt 540 gttattgaag caaacctaga tggagaattg aatttgaaaa tagaaactga attagtatgt 600 gttacaactc attttaaaga tcttggaaat cctccattag cctctgaaag cacccatgag 660 gacagaaacg tggaacacat ggctgaagtg cacatagata ttaggaagct cctacagttt 720 cttgctggac aacaagtaaa tcccacaaag gccttatgca atattgtgaa taacaagatg 780 gtgcattttg atctgcttca tgaagacgtg tcccttcagt atttcatccc tgcactgtcc 840 tag 843 <210> 270 <211> 560 <212> DNA <213> Homo sapiens <400> 270 ccagtcttga agactatgaa gagtgttgtg gaaaaaatga aaaacatcag caatcacctt 60 gttattgaag caaacctaga tggagaattg aatttgaaaa tagaaactga attagtatgt 120 gttacaactc attttaaagg atcttggaaa tcctccatta gcctctgaaa gcacccatga 180 ggacagaaac gtggaacaca tggctgaagt gcacatagat attaggaagc tcctacagtt 240 tcttgctgga caacaagtaa atcccacaaa ggccttatgc aatattgtga atracaagat 300 ggtgcatttt gatctgcttc atgaagacgt gtcccttcag tatttcatcc ctgcgctgtc 360 ctagcaccct gtcgctggag ttggcatgca gagactttgt caggatggga gaggccgcag 420 gtgttgtgtt ctgatcactg gtctgtgccc tcacagcacc gcacatcgac acactgtact 480 tatttgtccc tctctaacat tttaactaaa agttgattca acaacacaca gttggataaa 540 catatcactt catgttgctc 560 <210> 271 <211> 2216 <212> DNA <213> Homo sapiens <400> 271 ttgtgatgtc cttgtttcct ttctgtggct atgctggcct gcattcgctg ccccatatct 60 gtcccttggc tgctggttgt taacagttgc ctcttgattc tggctgggcc ccatcttgtg 120 aggtcacaca cctgctccag cactcttcat ctactgacca cacatgagaa aggcattacc 180 tgccaagagc ttttcaaggc atttttgtca ccttactact gaaatcacag caacctaaaa 240 gcgactgcgt cctggatttg aagttccacg ttttgtagca tagctcccag gctgagctga 300 gagggaggtt gagccaacac tgcacctcat ccccttcaga tctgcagtgt gctatagaga 360 aggaacagaa gattctaggt ggcaatgtca aggaccagcc cttttgaatg agagacatga 420 agagaatcag aagaggccat gggaggggca atgggtgttt gggaattggg gaaggtgtca 480 cacagttgga gtgatgggca cagaaggaga tatcgccaga gaagcagctc tgagggtaga 540 gatggagaag ctagactagg ccagatcatg gggagttttg gggtgaggta cctgtgctgc 600 attttaagga actttgacat ggacgatgtc atatttctag ggctgagcat agtgggagct 660 gtgtggcagt gcagggtcct taaaggtgct tctgagaacc tcaatgtgca tggagatcgc 720 ctgaaggtca tgtaaaggga ctccttattc atagtttggg ctgggcctca tggctgcact 780 tctcccaagc tcctgtacaa tgcccagacc cttggtcctg acaagcacag tgtgaatggt 840 gagagagtga aatacccctc ctgtctgcag agtgtggaaa cacagggtgt ggggggcccc 900 tgcgctgcac aacatcagtc tttgaacttg gtattttggg gaccttctga atccaaggct 960 gttgaggaac atggaagagt tcttatcaaa ggtggttgac taagccaagt gtcttcccag 1020 cattcacttt ggtgtctcca cgtgtagcag agaaaggaag accagcaaat tgtgatgtag 1080 caaaaatttt ttttaaaaca ccgtgggttg aacttctcat accttcttaa cttcccaaag 1140 ccccttttct gtctctgtta gtctccttca ggtgtcggct caattgtccc ctcctctagc 1200 taggtcctgc caccctcagt ctctgcctct cctgtgccct tgcaccgcct ctcctaaaga 1260 atgtttgtct tcctgcttgt cctttctggt cctttcccca acctcccatc tcctgggatt 1320 ggcctctctg cagcctactc acacatggtt tcttgtcact cactcatatc tgctggagag 1380 ctttcctcgg ctgctgtgct gcagcccccc gagctctcgg tggttgtcac actgtgtgct 1440 cctgcccacc ctcatgtgct ctttacttcc ctgcttggtt gcatgcctga tgccttggat 1500 tttagccatc acccatggcc ctcacgggat tggcaggacc gttgagatgc agggatccat 1560 cccatgtagc agtgtgtgac acagcctgcc ccaggtgttg ggggatcctg gctcttggct 1620 cttctcagca cagttcctcc actcactggt gaggagctgc tcttcgctgc agaaggatgc 1680 tcatgtgggt gaatgtggtt tgccaggaag ccagcctgct gggtgttttg ccaagggctt 1740 gggccgcttc actcttcctc tcctcgcaca gggagccgcc agtgctgggg ccgtgatgta 1800 gcctcagctg tggcagtgag agtgagagac tgtggtctct gcagctgcct cagggaagac 1860 agatgcctaa aacaggaggt gtaggctggg aaggctgttc tgaaaaagta gagatcaaaa 1920 tgtgtgtgct gcactaggtc tctaaaatca tggcttttct cttcccagat attgtgaata 1980 acaagatggt gcattttgat ctgcttcatg aagacgtgtc ccttcagtat ttcatccctg 2040 cactgtccta gcaccctgtc gctggagttg gcatgcagag actttgtcag gatgggagag 2100 gccgcaggtg ttgtgttctg atcactggtc tgtgccctca cagcaccgca catcgacaca 2160 ctgtacttat ttgtccctct ctaacatttt aactaaaggt tgattcaaca acacac 2216 <210> 272 <211> 2544 <212> DNA <213> Homo sapiens <400> 272 agcggagggc ttgccatcac accacacggg gtcatttact tatcacctac tccgcgctag 60 agtactatgc taagtgcgga ggacgcaaaa attaatgtca aagataatcc ttgttcacag 120 tattatgtct agcttaagaa gagttcttag ttgaatgaaa gctaattcta acaacttgtg 180 tgcacttctt ttgaataaaa accatcaact tatttgaatt cttaagtttc ctcctaaact 240 ccaacatttc aggaggaaga ggtcacattc tagtcatctt tgcaatctca aacccaaagg 300 aagcctaact tggtacagtg catggcacat tcaatgtctg ttgaatacaa gtaaagctca 360 tactacctag tctatttttc agtatctctt gagttaatga cctggttaac aagtcagagt 420 cacagtccca agggcaacaa ctttttaaag gctcccctaa cgtacttcag gatccctgac 480 tgagagtggc tgactatggc agtatatggg catactaatc actggagaaa taatagcgag 540 aaataaccaa ggaaaagcac tactctccaa aaacattaaa aaaaaaaaac aactgaacaa 600 ctagtaagaa agaacgctgg atctgagcac cctgtaagtc gcttccccgt gggccgggta 660 aaggttttaa aacccgccgc ctccaggaag acggccacgt gcacaaggat tagctgcaaa 720 ctccgtgccc agtctggccg ggagaattgc taaaaccgac ctaccgttaa cacccgggct 780 actctgaaat taagcaaggc tgtagtcaag taagtaaccc aagaaaaggc gcacagagcc 840 gccgccgcag gtgtagcccg gggacatccc ctcctacctt gcaaacgggg cctgggatcc 900 ggtccctctc ttcttcctcc acctcctctg ctgtggcgtg ccgcttagct ggcggctccg 960 catctatttc gtttcttttt ggcttcttcg cctgaactgc aaagcctcca cgccgtttcc 1020 tcttggttgc cgccatcttg cctcgccgcc cgcgctcttg gcctcctttc cggcgctgcc 1080 gctcgctcct atttccgatc tctatggttc ggcggctcta agcgctcagc tccgcggtcg 1140 tcctccaggt ctgtgccgcc tccttccggt ctcggtggcg cggcacgcgc ggctctctag 1200 gcctccttca gctctgtggt gacggtggcc gaggtggagg gccggtctga agagtggcgg 1260 gactggcttc acttcctccg cggttcctcg gagccgcctc gctcctcttc agggactttg 1320 ctgagaaggg ctctcgggcg tccagacccc accgcaaagg tgtttggcga tccgccgaga 1380 agttgttggc cccaggagca tccctcgggg ccgaatgcgc agtggacgat gccccttctg 1440 acccaacaga tccaagacga ggatgatcag tacagccttg tggccagcct tgacaacgtt 1500 aggaatctct ccactatctt gaaagctatt catttccgag aacatgccac gtgtttcgca 1560 actaaaaatg gtatcaaagt aacagtggaa aatgcaaagt gtgtgcaagc aaatgctttt 1620 attcaggctg gaatatttca ggagtttaaa gttcaggaag agtctgttac ttttcgaatt 1680 aatttaactg tccttttaga ctgtttatct atttttggat caagtcctat gccagggact 1740 ttaactgcac ttcgaatgtg ttaccaaggt tatggttacc ctttgatgct gttcctggaa 1800 gaaggaggag tggtgacagt ctgcaaaatc aatacacagg aacctgagga gaccctggac 1860 tttgatttct gcagcaccaa tgttattaat aaaattattc tgcagtcaga ggggctccgt 1920 gaagcatttt ctgaattgga tatgacgagt gaagtcctac aaattaccat gtctcctgac 1980 aagccttatt tcaggttatc tacttttgga aatgcaggaa gttcccacct tgactatccc 2040 aaagattctg atttgatgga agcatttcat tgtaatcaga cccaagtcaa cagatacaag 2100 atttccttac tgaaaccctc tacaaaggca ttagtcctat cttgtaaggt atctattcgg 2160 acagataaca gaggcttcct ttcattacag tatatgatta gaaatgaaga tggacaaata 2220 tgttttgtgg aatattactg ctgccctgat gaagaagttc ctgaatctga gtcttgagta 2280 tgacaattca ctgatattta tgtgtacatt tatgatagat gaagttctta ttctgagtac 2340 agtactcttt gtcatttcat attggatttt ctatagagaa gaagcacaat ggggaagata 2400 ggagcaaggt catgtaccct aatagttact atgttttgta aatccatttt gtagagggca 2460 tgtaaataaa tgttttcctg taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2520 aaaaaaaaga aaaaaaaaaa aaaa 2544 <210> 273 <211> 1259 <212> DNA <213> Homo sapiens <400> 273 ggggtccgcg gttcctcgga gccgcctcgc tcctcttcag ggactttgct gagaagggct 60 ctcgggcgtc cagaccccac cgcaaaggtg tttggcgatc cgccgagaag ttgttggccc 120 caggagcatc cctcggggcc gaatgcgcag tggacgatgc cccttctgac ccaacagatc 180 caagacgagg atgatcagta cagccttgtg gccagccttg acaacgttag gaatctctcc 240 actatcttga aagctattca tttccgagaa catgccacgt gtttcgcaac taaaaatggt 300 atcaaagtaa cagtggaaaa tgcaaagtgt gtgcaagcaa atgcttttat tcaggctgga 360 atatttcagg agtttaaagt tcaggaagag tctgttactt ttcgaattaa tttaactgtc 420 cttttagact gtttatctat ttttggatca agtcctatgc cagggacttt aactgcactt 480 cgaatgtgtt accaaggtta tggttaccct ttgatgctgt tcctggaaga aggaggagtg 540 gtgacagtct gcaaaatcaa tacacaggaa cctgaggaga ccctggactt tgatttctgc 600 agcaccaatg ttattaataa aattattctg cagtcagagg ggctccgtga agcattttct 660 gaattggata tgacgagtga agtcctacaa attaccatgt ctcctgacaa gccttatttc 720 aggttatcta cttttggaaa tgcaggaagt tcccaccttg actatcccaa agattctgat 780 ttgatggaag catttcattg taatcagacc caagtcaaca gatacaagat ttccttactg 840 aaaccctcta caaaggcatt agtcctatct tgtaaggtat ctattcggac agataacaga 900 ggcttccttt cattacagta tatgattaga aatgaagatg gacaaatatg ttttgtggaa 960 tattactgct gccctgatga agaagttcct gaatctgagt cttgagtatg acaattcact 1020 gatatttatg tgtacattta tgatagatga agttcttatt ctgagtacag tactctttgt 1080 catttcatat tggattttct atagagaaga agcacaatgg ggaagatagg agcaaggtca 1140 tgtaccctaa tagttactat gttttgtaaa tccattttgt agagggcatg taaataaatg 1200 ttttcctgta gtcataaaaa aaaaaaaaca aaaaaaaaaa aaaaaaaaaa aaaaaaaaa 1259 <210> 274 <211> 1862 <212> DNA <213> Homo sapiens <400> 274 gccggctgaa gtgctcacgg ctcactgcag tttcaagttc ctgggctcaa agatgggagt 60 ctccctatgt tgcccaggct ggtctccaac acctgggctc aagtggcttg gcctcccaaa 120 gcgctgggat tataggtctg tgccgcctcc ctccggtctc ggtggcgcgg cacgcgcggc 180 tctctaggcc tccttcagct ctgtggtgac ggtggccgag gtggagggcc ggtctgaaga 240 gtggcgggac tggcttcact tcctccgcgg ttcctcggag ccgcctcgct cctcttcagg 300 gactttgctg agaagggctc tcgggcgtcc agaccccacc gcaaaggtgt ttggcgatcc 360 gccgagaagt tgttggcccc aggagcatcc ctcggggccg aatgcgcagt ggacgatgcc 420 ccttctgacc caacagatcc aagacgagga tgatcagtac agccttgtgg ccagccttga 480 caacgttagg aatctctcca ctatcttgaa agctattcat ttccgagaac atgccacgtg 540 tttcgcaact aaaaatggta tcaaagtaac agtggaaaat gcaaagtgtg tgcaagcaaa 600 tgcttttatt caggctggaa tatttcagga gtttaaagtt caggaagagt ctgttacttt 660 tcgaattaat ttaactgtcc ttttagactg tttatctatt tttggatcaa gtcctatgcc 720 agggacttta actgcacttc gaatgtgtta ccaaggttat ggttaccctt tgatgctgtt 780 cctggaagaa ggaggagtgg tgacagtctg caaaatcaat acacaggaac ctgaggagac 840 cctggacttt gatttctgca gcaccaatgt tattaataaa attattctgc agtcagaggg 900 gctccgtgaa gcattttctg aattggatat gacgagtgaa gtcctacaaa ttaccatgtc 960 tcctgacaag ccttatttca ggttatctac ttttggaaat gcaggaagtt cccaccttga 1020 ctatcccaaa gattctgatt tgatggaagc atttcattgt aatcagaccc aagtcaacag 1080 atacaagatt tccttactga aaccctctac aaaggcatta gtcctatctt gtaaggtatc 1140 tattcggaca gataacagag gcttcctttc attacagtat atgattagaa atgaagatgg 1200 acaaatatgt tttgtggaat attactgctg ccctgatgaa gaagttcctg aatctgagtc 1260 ttgagtatga caattcactg atatttatgt gtacatttat gatagatgaa gttcttattc 1320 tgagtacagt actctttgtc atttcatatt ggattttcta tagagaagaa gcacaatggg 1380 gaagatagga gcaaggtcat gtaccctaat agttactatg ttttgtaaat ccattttgta 1440 gagggcatgt aaataaatgt tttcctgtag tcatagatta ttcaggactg tcctttagtt 1500 ctgtcttttg aactcatggg aataattgtg agtcagcgta acatttcaag agtctaaagg 1560 tggccgggtg tggtggcttt aatcccagca ctttgggaac ccgaggtggg cggatcacct 1620 gaggtcagga gttcgaaacc agcctgacca acgtggagaa accccatctc tactaaaaat 1680 acaaaaaatt agccggacgt ggtggcacat gcctgtaatg ccagctactc gggaggctga 1740 ggcaggaaaa ttgcttgaac ccgggaggcg gaggttgtgg tgagctgaaa tgacgccatt 1800 gcactccagc ctaggcaata agagcaaaac tctgcctcaa aaaaaaaaaa aaaaaaaaaa 1860 aa 1862 <210> 275 <211> 1776 <212> DNA <213> Homo sapiens <400> 275 ctctatggtt cggcggctct aagcgctcag ctccgcggtc gtcctccagg tctgtgccgc 60 ctccctccgg tctcggtggc gcggcacgcg cggctctcta ggcctccttc agctctgtgg 120 tgacggtggc cgaggtggag ggccggtctg aagagtggcg ggactggctt cacttcctcc 180 gcggttcctc ggagccgcct cgctcctctt cagggacttt gctgagaagg gctctcgggc 240 gtccagaccc caccgcaaag gtgtttggcg atccgccgag aagttgttgg ccccaggagc 300 atccctcggg gccgaatgcg cagtggacga tgccccttct gacccaacag atccaagacg 360 aggatgatca gtacagcctt gtggccagcc ttgacaacgt taggaatctc tccactatct 420 tgaaagctat tcatttccga gaacatgcca cgtgtttcgc aactaaaaat ggtatcaaag 480 taacagtgga aaatgcaaag tgtgtgcaag caaatgcttt tattcaggct ggaatatttc 540 aggagtttaa agttcaggaa gagtctgtta cttttcgaat taatttaact gtccttttag 600 actgtttatc tatttttgga tcaagtccta tgccagggac tttaactgca cttcgaatgt 660 gttaccaagg ttatggttac cctttgatgc tgttcctgga agaaggagga gtggtgacag 720 tctgcaaaat caatacacag gaacctgagg agaccctgga ctttgatttc tgcagcacca 780 atgttattaa taaaattatt ctgcagtcag aggggctccg tgaagcattt tctgaattgg 840 atatgacgag tgaagtccta caaattacca tgtctcctga caagccttat ttcaggttat 900 ctacttttgg aaatgcagga agttcccacc ttgactatcc caaagattct gatttgatgg 960 aagcatttca ttgtaatcag acccaagtca acagatacaa gatttcctta ctgaaaccct 1020 ctacaaaggc attagtccta tcttgtaagg tatctattcg gacagataac agaggcttcc 1080 tttcattaca gtatatgatt agaaatgaag atggacaaat atgttttgtg gaatattact 1140 gctgccctga tgaagaagtt cctgaatctg agtcttgagt atgacaattc actgatattt 1200 atgtgtacat ttatgataga tgaagttctt attctgagta cagtactctt tgtcatttca 1260 tattggattt tctatagaga agaagcacaa tggggaagat aggagcaagg tcatgtaccc 1320 taatagttac tatgttttgt aaatccattt tgtagagggc atgtaaataa atgttttcct 1380 gtagtcatag attattcagg actgtccttt agttctgtct tttgaactca tgggaataat 1440 tgtgagtcag cgtaacattt caagagtcta aaggtggccg ggtgtggtgg ctttaatccc 1500 agcactttgg gaacccgagg tgggcggatc acctgaggtc aggagttcga aaccagcctg 1560 accaacgtgg agaaacccca tctctactaa aaatacaaaa aattagccgg acgtggtggc 1620 acatgcctgt aatgccagct actcgggagg ctgaggcagg aaaattgctt gaacccggga 1680 ggcggaggtt gtggtgagct gaaatgacgc cattgcactc cagcctaggc aataagagca 1740 aaactctgcc tcaaaaaaaa aaaaaaaaaa aaaaaa 1776 <210> 276 <211> 1614 <212> DNA <213> Homo sapiens <400> 276 tgaagagtgg cgggactggc ttcacttcct ccgcggttcc tcggagccgc ctcgctcctc 60 ttcagggact ttgctgagaa gggctctcgg gcgtccagac cccaccgcaa aggtgtttgg 120 cgatccgccg agaagttgtt ggccccagga gcatccctcg gggccgaatg cgcagtggac 180 gatgcccctt ctgacccaac agatccaaga cgaggatgat cagtacagcc ttgtggccag 240 ccttgacaac gttaggaatc tctccactat cttgaaagct attcatttcc gagaacatgc 300 cacgtgtttc gcaactaaaa atggtatcaa agtaacagtg gaaaatgcaa agtgtgtgca 360 agcaaatgct tttattcagg ctggaatatt tcaggagttt aaagttcagg aagagtctgt 420 tacttttcga attaatttaa ctgtcctttt agactgttta tctatttttg gatcaagtcc 480 tatgccaggg actttaactg cacttcgaat gtgttaccaa ggttatggtt accctttgat 540 gctgttcctg gaagaaggag gagtggtgac agtctgcaaa atcaatacac aggaacctga 600 ggagaccctg gactttgatt tctgcagcac caatgttatt aataaaatta ttctgcagtc 660 agaggggctc cgtgaagcat tttctgaatt ggatatgacg agtgaagtcc tacaaattac 720 catgtctcct gacaagcctt atttcaggtt atctactttt ggaaatgcag gaagttccca 780 ccttgactat cccaaagatt ctgatttgat ggaagcattt cattgtaatc agacccaagt 840 caacagatac aagatttcct tactgaaacc ctctacaaag gcattagtcc tatcttgtaa 900 ggtatctatt cggacagata acagaggctt cctttcatta cagtatatga ttagaaatga 960 agatggacaa atatgttttg tggaatatta ctgctgccct gatgaagaag ttcctgaatc 1020 tgagtcttga gtatgacaat tcactgatat ttatgtgtac atttatgata gatgaagttc 1080 ttattctgag tacagtactc tttgtcattt catattggat tttctataga gaagaagcac 1140 aatggggaag ataggagcaa ggtcatgtac cctaatagtt actatgtttt gtaaatccat 1200 tttgtagagg gcatgtaaat aaatgttttc ctgtagtcat agattattca ggactgtcct 1260 ttagttctgt cttttgaact catgggaata attgtgagtc agcgtaacat ttcaagagtc 1320 taaaggtggc cgggtgtggt ggctttaatc ccagcacttt gggaagccga ggtgggcgga 1380 tcacctgagg tcaggagttc gagaccagcc tgaccaacgt ggagaaaccc catctctact 1440 aaaaatacaa aaaattggcc ggacgtggtg gcacatgcct gtaatgccag ctactcggga 1500 ggctgaggca ggagaattgc ttgaacccgg gaggtggagg ttgtggtgag ctgagatgac 1560 gccattgcac tccagcctag gcaataagag caaaactctg ctcaaaaaaa aaaa 1614 <210> 277 <211> 1396 <212> DNA <213> Homo sapiens <400> 277 ggactctatg gttcggcggc tctaagcgct cagctccgcg gtcgtcctcc aggtctgtgc 60 cgcctccttc cggtctcggt ggcgcggcac gcgcggctct ctaggcctcc ttcagctctg 120 tggtgacggt ggccgaggtg gagggccggt ctgaagagtg gcgggactgg cttcacttcc 180 tccgcggttc ctcggagccg cctcgctcct cttcagggac tttgctgaga agggctctcg 240 ggcgtccaga ccccaccgca aaggtgtttg gcgatccgcc gagaagttgt tggccccagg 300 agcgtccctc ggggccgaat gcgcagtgga cgatgcccct tctgacccaa cagatccaag 360 acgaggatga tcagtacagc cttgtggcca gccttgacaa cgttaggaat ctctccacta 420 tcttgaaagc tattcatttc cgagaacatg ccacgtgttt cgcaactaaa aatggtatca 480 aagtaacagt ggaaaatgca aagtgtgtgc aagcaaatgc ttttattcag gctggaatat 540 ttcaggagtt taaagttcag gaagagtctg ttacttttcg aattaattta actgtccttt 600 tagactgttt atctattttt ggatcaagtc ctatgccagg gactttaact gcacttcgaa 660 tgtgttacca aggttatggt taccctttga tgctgttcct ggaagaagga ggagtggtga 720 cagtctgcaa aatcaataca caggaacctg aggagaccct ggactttgat ttctgcagca 780 ccaatgttat taataaaatt attctgcagt cagaggggct ccgtgaagca ttttctgaat 840 tggatatgac gagtgaagtc ctacaaatta ccatgtctcc tgacaagcct tatttcaggt 900 tatctacttt tggaaatgca ggaagttccc accttgacta tcccaaagat tctgatttga 960 tggaagcatt tcattgtaat cagacccaag tcaacagata caagatttcc ttactgaaac 1020 cctctacaaa ggcattagtc ctatcttgta aggtatctat tcggacagat aacagaggct 1080 tcctttcatt acagtatatg attagaaatg aagatggaca aatatgtttt gtggaatatt 1140 actgctgccc tgatgaagaa gttcctgaat ctgagtcttg agtatgacaa ttcactgata 1200 tttatgtgta catttatgat agatgaagtt cttattctga gtacagtact ctttgtcatt 1260 tcatattggg ttttctatag agaagaagca caatggggaa gataggagca aggtcatgta 1320 ccctaatagt tactatgttt tgtaaatcca ttttgtagag ggcatgtaaa taaatgtttt 1380 cctgtagtca tagatt 1396 <210> 278 <211> 1051 <212> DNA <213> Homo sapiens <400> 278 ggagccgcct cgctcctctt cagggacttt gctgagaagg gctctcgggc gtccagaccc 60 caccgcaaag gtgtttggcg atccgcgaga agttgttggc cccaggagca tccctcgggg 120 ccgaatgcgc agtgggacga tgccccttct gacccaacag atccaagacg aggatgatca 180 gtacagcctt gtggccagcc ttgacaacgt taggaatctc tccactatct tgaaagctat 240 tcatttccga gaacatgcca cgtgtttcgc aactaaaaat ggtatcaaag taacagtgga 300 aaatgcaaag tgtgtgcaag caaatgcttt tattcaggct ggaatatttc aggagtttaa 360 agttcaggaa gagtctgtta cttttcgaat taatttaact gtccttttag actgtttatc 420 tatttttgga tcaagtccta tgccagggac tttaactgca cttcgaatgt gttaccaagg 480 ttatggttac cctttgatgc tgttcctgga agaaggagga gtggtgacag tctgcaaaat 540 caatacacag gaacctgagg agaccctgga ctttgatttc tgcagcacca atgttattaa 600 taaaattatt ctgcagtcag aggggctccg tgaagcattt tctgaattgg atatgacgag 660 tgaagtccta caaattacca tgtctcctga caagccttat ttcaggttat ctacttttgg 720 aaatgcagga agttcccacc ttgactatcc caaagattct gatttgatgg aagcatttca 780 ttgtaatcag acccaagtca acagatacaa gatttcctta ctgaaaccct ctacaaaggc 840 attagtccta tcttgtaagg tatctattcg gacagataac agaggcttcc tttcattaca 900 gtatatgatt agaaatgaag atggacaaat atgttttgtg gaatattact gctgccctga 960 tgaagaagtt cctgaatctg agtcttgagt atgacaattc actgatattt atgtgtacat 1020 ttatgataga tgaagttctt attctgagta c 1051 <210> 279 <211> 1259 <212> DNA <213> Homo sapiens <400> 279 gtggagggcc ggtctgaaga gtggcgggac tggcttcact tcctccgcgg ttcctcggag 60 ccgcctcgct cctcttcagg gactttgctg agaagggctc tcgggcgtcc agaccccacc 120 gcaaaggtgt ttggcgatcc gccgagaagt tgttggcccc aggagcatcc ctcggggccg 180 aatgcgcagt ggacgatgcc ccttctgacc caacagatcc aagacgagga tgatcagtac 240 agccttgtgg ccagccttga caacgttagg aatctctcca ctatcttgaa agctattcat 300 ttccgagaac atgccacgtg tttcgcaact aaaaatggta tcaaagtaac agtggaaaat 360 gcaaagtgtg tgcaagcaaa tgcttttatt caggctggaa tatttcagga gtttaaagtt 420 caggaagagt ctgttacttt tcgaattaat ttaactgtcc ttttagactg tttatctatt 480 tttggatcaa gtcctatgcc agggacttta actgcacttc gaatgtgtta ccaaggttat 540 ggttaccctt tgatgctgtt cctggaagaa ggaggagtgg tgacagtctg caaaatcaat 600 acacaggaac ctgaggagac cctggacttt gatttctgca gcaccaatgt tattaataaa 660 attattctgc agtcagaggg gctccgtgaa gcattttctg aattggatat gacgagtgaa 720 gtcctacaaa ttaccatgtc tcctgacaag ccttatttca ggttatctac ttttggaaat 780 gcaggaagtt cccaccttga ctatcccaaa gattctgatt tgatggaagc atttcattgt 840 aatcagaccc aagtcaacag atacaagatt tccttactga aaccctctac aaaggcatta 900 gtcctatctt gtaaggtatc tattcggaca gataacagag gcttcctttc attacagtat 960 atgattagaa atgaagatgg acaaatatgt tttgtggaat attactgctg ccctgatgaa 1020 gaagttcctg aatctgagtc ttgagtatga caattcactg atatttatgt gtacatttat 1080 gatagatgaa gttcttattc tgagtacagt actctttgtc atttcatatt ggattttcta 1140 tagagaagaa gcacaatggg gaagatagga gcaaggtcat gtaccctaat agttactatg 1200 ttttgtaaat ccattttgta gagggcatgt aaataaatgt tttcctgtag tcatagatt 1259 <210> 280 <211> 1884 <212> DNA <213> Homo sapiens <400> 280 aggaaccgcg gaggaagtga aggccggctg aagtgctcac ggctcactgc agtttcaagt 60 tcctgggctc aaagatggga gtctccctat gttgcccagg ctggtctcca acacctgggc 120 tcaagtggct tggcctccca aagcgctggg attataggtc tgtgccgcct ccctccggtc 180 tcggtggcgc ggcacgcgcg gctctctagg cctccttcag ctctgtggtg acggtggccg 240 aggtggaggg ccggtctgaa gagtggcggg actggcttca cttcctccgc ggttcctcgg 300 agccgcctcg ctcctcttca gggactttgc tgagaagggc tctcgggcgt ccagacccca 360 ccgcaaaggt gtttggcgat ccgccgagaa gttgttggcc ccaggagcat ccctcggggc 420 cgaatgcgca gtggacgatg ccccttctga cccaacagat ccaagacgag gatgatcagt 480 acagccttgt ggccagcctt gacaacgtta ggaatctctc cactatcttg aaagctattc 540 atttccgaga acatgccacg tgtttcgcaa ctaaaaatgg tatcaaagta acagtggaaa 600 atgcaaagtg tgtgcaagca aatgctttta ttcaggctgg aatatttcag gagtttaaag 660 ttcaggaaga gtctgttact tttcgaatta atttaactgt ccttttagac tgtttatcta 720 tttttggatc aagtcctatg ccagggactt taactgcact tcgaatgtgt taccaaggtt 780 atggttaccc tttgatgctg ttcctggaag aaggaggagt ggtgacagtc tgcaaaatca 840 atacacagga acctgaggag accctggact ttgatttctg cagcaccaat gttattaata 900 aaattattct gcagtcagag gggctccgtg aagcattttc tgaattggat atgacgagtg 960 aagtcctaca aattaccatg tctcctgaca agccttattt caggttatct acttttggaa 1020 atgcaggaag ttcccacctt gactatccca aagattctga tttgatggaa gcatttcatt 1080 gtaatcagac ccaagtcaac agatacaaga tttccttact gaaaccctct acaaaggcat 1140 tagtcctatc ttgtaaggta tctattcgga cagataacag aggcttcctt tcattacagt 1200 atatgattag aaatgaagat ggacaaatat gttttgtgga atattactgc tgccctgatg 1260 aagaagttcc tgaatctgag tcttgagtat gacaattcac tgatatttat gtgtacattt 1320 atgatagatg aagttcttat tctgagtaca gtactctttg tcatttcata ttggattttc 1380 tatagagaag aagcacaatg gggaagatag gagcaaggtc atgtacccta atagttacta 1440 tgttttgtaa atccattttg tagagggcat gtaaataaat gttttcctgt agtcatagat 1500 tattcaggac tgtcctttag ttctgtcttt tgaactcatg ggaataattg tgagtcagcg 1560 taacatttca agagtctaaa ggtggccggg tgtggtggct ttaatcccag cactttggga 1620 acccgaggtg ggcggatcac ctgaggtcag gagttcgaaa ccagcctgac caacgtggag 1680 aaaccccatc tctactaaaa atacaaaaaa ttagccggac gtggtggcac atgcctgtaa 1740 tgccagctac tcgggaggct gaggcaggaa aattgcttga acccgggagg cggaggttgt 1800 ggtgagctga aatgacgcca ttgcactcca gcctaggcaa taagagcaaa actctgcctc 1860 aaaaaaaaaa aaaaaaaaaa aaaa 1884 <210> 281 <211> 1263 <212> DNA <213> Homo sapiens <400> 281 ggcacgaggg tggagggccg gtctgaagag tggcgggact ggcttcactt cctccgcggt 60 tcctcggagc cgcctcgctc ctcttcaggg actttgctga gaagggctct cgggcgtcca 120 gaccccaccg caaaggtgtt tggcgatccg ccgagaagtt gttggcccca ggagcatccc 180 tcggggccga atgcgcagtg gacgatgccc cttctgaccc aacagatcca agacgaggat 240 gatcagtaca gccttgtggc cagccttgac aacgttagga atctctccac tatcttgaaa 300 gctattcatt tccgagaaca tgccacgtgt ttcgcaacta aaaatggtat caaagtaaca 360 gtggaaaatg caaagtgtgt gcaagcaaat gcttttattc aggctggaat atttcaggag 420 tttaaagttc aggaagagtc tgttactttt cgaattaatt taactgtcct tttagactgt 480 ttatctattt ttggatcaag tcctatgcca gggactttaa ctgcacttcg aatgtgttac 540 caaggttatg gttacccttt gatgctgttc ctggaagaag gaggagtggt gacagtctgc 600 aaaatcaata cacaggaacc tgaggagacc ctggactttg atttctgcag caccaatgtt 660 attaataaaa ttattctgca gtcagagggg ctccgtgaag cattttctga attggatatg 720 acgagtgaag tcctacaaat taccatgtct cctgacaagc cttatttcag gttatctact 780 tttggaaatg caggaagttc ccaccttgac tatcccaaag attctgattt gatggaagca 840 tttcattgta atcagaccca agtcaacaga tacaagattt ccttactgaa accctctaca 900 aaggcattag tcctatcttg taaggtatct attcggacag ataacagagg cttcctttca 960 ttacagtata tgattagaaa tgaagatgga caaatatgtt ttgtggaata ttactgctgc 1020 cctgatgaag aagttcctga atctgagtct tgagtatgac aattcactga tatttatgtg 1080 tacatttatg atagatgaag ttcttattct gagtacagta ctctttgtca tttcatattg 1140 gattttctat agagaagaag cacaatgggg aagataggag caaggtcatg taccctaata 1200 gttactatgt tttgtaaatc cattttgtag agggcatgta aataaatgtt ttcctgtagt 1260 cat 1263 <210> 282 <211> 849 <212> DNA <213> Homo sapiens <400> 282 atgccccttc tgacccaaca gatccaagac gaggatgatc agtacagcct tgtggccagc 60 cttgacaacg ttaggaatct ctccactatc ttgaaagcta ttcatttccg agaacatgcc 120 acgtgtttcg caactaaaaa tggtatcaaa gtaacagtgg aaaatgcaaa gtgtgtgcaa 180 gcaaatgctt ttattcaggc tggaatattt caggagttta aagttcagga agagtctgtt 240 acttttcgaa ttaatttaac tgtcctttta gactgtttat ctatttttgg atcaagtcct 300 atgccaggga ctttaactgc acttcgaatg tgttaccaag gttatggtta ccctttgatg 360 ctgttcctgg aagaaggagg agtggtgaca gtctgcaaaa tcaatacaca ggaacctgag 420 gagaccctgg actttgattt ctgcagcacc aatgttatta ataaaattat tctgcagtca 480 gaggggctcc gtgaagcatt ttctgaattg gatatgacga gtgaagtcct acaaattacc 540 atgtctcctg acaagcctta tttcaggtta tctacttttg gaaatgcagg aagttcccac 600 cttgactatc ccaaagattc tgatttgatg gaagcatttc attgtaatca gacccaagtc 660 aacagataca agatttcctt actgaaaccc tctacaaagg cattagtcct atcttgtaag 720 gtatctattc ggacagataa cagaggcttc ctttcattac agtatatgat tagaaatgaa 780 gatggacaaa tatgttttgt ggaatattac tgctgccctg atgaagaagt tcctgaatct 840 gagtcttga 849 <210> 283 <211> 1300 <212> DNA <213> Homo sapiens <400> 283 gaattcggca cgagccgagg tggagggccg gtctgaagag tggcgggact ggcttcactt 60 cctccgcggt tcctcggagc cgcctcgctc ctcttcaggg actttgctga gaagggctct 120 cgggcgtcca gaccccaccg caaaggtgtt tggcgatccg ccgagaagtt gttggcccca 180 ggagcatccc tcggggccga atgcgcagtg gacgatgccc cttctgaccc aacagatcca 240 agacgaggat gatcagtaca gccttgtggc cagccttgac aacgttagga atctctccac 300 tatcttgaaa gctattcatt tccgagaaca tgccacgtgt ttcgcaacta aaaatggtat 360 caaagtaaca gtggaaaatg caaagtgtgt gcaagcaaat gcttttattc aggctggaat 420 atttcaggag tttaaagttc aggaagagtc tgttactttt cgaattaatt taactgtcct 480 tttagactgt ttatctattt ttggatcaag tcctatgcca gggactttaa ctgcacttcg 540 aatgtgttac caaggttatg gttacccttt gatgctgttc ctggaagaag gaggagtggt 600 gacagtctgc aaaatcaata cacaggaacc tgaggagacc ctggactttg atttctgcag 660 caccaatgtt attaataaaa ttattctgca gtcagagggg ctccgtgaag cattttctga 720 attggatatg acgagtgaag tcctacaaat taccatgtct cctgacaagc cttatttcag 780 gttatctact tttggaaatg caggaagttc ccaccttgac tatcccaaag attctgattt 840 gatggaagca tttcattgta atcagaccca agtcaacaga tacaagattt ccttactgaa 900 accctctaca aaggcattag tcctatcttg taaggtatct attcggacag ataacagagg 960 cttcctttca ttacagtata tgattagaaa tgaagatgga caaatatgtt ttgtggaata 1020 ttactgctgc cctgatgaag aagttcctga atctgagtct tgagtatgac aattcactga 1080 tatttatgtg tacatttatg atagatgaag ttcttattct gagtacagta ctctttgtca 1140 tttcatattg gattttctat agagaagaag cacaatgggg aagataggag caaggtcatg 1200 taccctaata gttactatgt tttgtaaatc cattttgtag agggcatgta aataaatgtt 1260 ttcctgtagt catagattaa aaaaaaaaaa aaaactcgag 1300 <210> 284 <211> 1243 <212> DNA <213> Homo sapiens <400> 284 gcttcacttc ctccgcggtt cctcggagcc gcctcgctcc tcttcaggga ctttgctgag 60 aagggctctc gggcgtccag accccaccgc aaaggtgttt ggcgatccgc cgagaagttg 120 ttggccccag gagcatccct cggggccgaa tgcgcagtgg acgatgcccc ttctgaccca 180 acagatccaa gacgaggatg atcagtacag ccttgtggcc agccttgaca acgttaggaa 240 tctctccact atcttgaaag ctattcattt ccgagaacat gccacgtgtt tcgcaactaa 300 aaatggtatc aaagtaacag tggaaaatgc aaagtgtgtg caagcaaatg cttttattca 360 ggctggaata tttcaggagt ttaaagttca ggaagagtct gttacttttc gaattaattt 420 aactgtcctt ttagactgtt tatctatttt tggatcaagt cctatgccag ggactttaac 480 tgcacttcga atgtgttacc aaggttatgg ttaccctttg atgctgttcc tggaagaagg 540 aggagtggtg acagtctgca aaatcaatac acaggaacct gaggagaccc tggactttga 600 tttctgcagc accaatgtta ttaataaaat tattctgcag tcagaggggc tccgtgaagc 660 attttctgaa ttggatatga cgagtgaagt cctacaaatt accatgtctc ctgacaagcc 720 ttatttcagg ttatctactt ttggaaatgc aggaagttcc caccttgact atcccaaaga 780 ttctgatttg atggaagcat ttcattgtaa tcagacccaa gtcaacagat acaagatttc 840 cttactgaaa ccctctacaa aggcattagt cctatcttgt aaggtatcta ttcggacaga 900 taacagaggc ttcctttcat tacagtatat gattagaaat gaagatggac aaatatgttt 960 tgtggaatat tactgctgcc ctgatgaaga agttcctgaa tctgagtctt gagtatgaca 1020 attcactgat atttatgtgt acatttatga tagatgaagt tcttattctg agtacagtac 1080 tctttgtcat ttcatattgg attttctata gagaagaagc acaatgggga agataggagc 1140 aaggtcatgt accctaatag ttactatgtt ttgtaaatcc attttgtaga gggcatgtaa 1200 ataaatgttt tcctgtagtc ataaaaaaaa aaaaaaaaaa aaa 1243 <210> 285 <211> 849 <212> DNA <213> Homo sapiens <400> 285 atgccccttc tgacccaaca gatccaagac gaggatgatc agtacagcct tgtggccagc 60 cttgacaacg ttaggaatct ctccactatc ttgaaagcta ttcatttccg agaacatgcc 120 acgtgtttcg caactaaaaa tggtatcaaa gtaacagtgg aaaatgcaaa gtgtgtgcaa 180 gcaaatgctt ttattcaggc tggaatattt caggagttta aagttcagga agagtctgtt 240 acttttcgaa ttaatttaac tgtcctttta gactgtttat ctatttttgg atcaagtcct 300 atgccaggga ctttaactgc acttcgaatg tgttaccaag gttatggtta ccctttgatg 360 ctgttcctgg aagaaggagg agtggtgaca gtctgcaaaa tcaatacaca ggaacctgag 420 gagaccctgg actttgattt ctgcagcacc aatgttatta ataaaattat tctgcagtca 480 gaggggctcc gtgaagcatt ttctgaattg gatatgacga gtgaagtcct acaaattacc 540 atgtctcctg acaagcctta tttcaggtta tctacttttg gaaatgcagg aagttcccac 600 cttgactatc ccaaagattc tgatttgatg gaagcatttc attgtaatca gacccaagtc 660 aacagataca agatttcctt actgaaaccc tctacaaagg cattagtcct atcttgtaag 720 gtatctattc ggacagataa cagaggcttc ctttcattac agtatatgat tagaaatgaa 780 gatggacaaa tatgttttgt ggaatattac tgctgccctg atgaagaagt tcctgaatct 840 gagtcttag 849 <210> 286 <211> 1254 <212> DNA <213> Homo sapiens <400> 286 gtggagggcc ggtctgaaga gtggcgggac tggcttcact tcctccgcgg ttcctcggag 60 ccgcctcgct cctcttcagg gactttgctg agaagggctc tcgggcgtcc agaccccacc 120 gcaaaggtgt ttggcgatcc gcgagaagtt gttggcccca ggagcatccc tcggggccga 180 atgcgcagtg ggacgatgcc ccttctgacc caacagatcc aagacgagga tgatcagtac 240 agccttgtgg ccagccttga caacgttagg aatctctcca ctatcttgaa agctattcat 300 ttccgagaac atgccacgtg tttcgcaact aaaaatggta tcaaagtaac agtggaaaat 360 gcaaagtgtg tgcaagcaaa tgcttttatt caggctggaa tatttcagga gtttaaagtt 420 caggaagagt ctgttacttt tcgaattaat ttaactgtcc ttttagactg tttatctatt 480 tttggatcaa gtcctatgcc agggacttta actgcacttc gaatgtgtta ccaaggttat 540 ggttaccctt tgatgctgtt cctggaagaa ggaggagtgg tgacagtctg caaaattacc 600 actcaggaac ctgaggagac cctggacttt gatttctgca gcaccaatgt tattaataaa 660 attattctgc agtcagaggg gctccgagaa gcattttctg aattggatat gacgagtgaa 720 gtcctacaaa ttaccatgtc tcctgacaag ccttatttca ggttatctac ttttggaaat 780 gcaggaagtt cccaccttga ctatcccaaa gattctgatt tgatggaagc atttcattgt 840 aatcagaccc aagtcaacag atacaagatt tccttactga aaccctctac aaaggcatta 900 gtcctatctt gtaaggtatc tattcggaca gataacagag gcttcctttc attacagtat 960 atgattagaa atgaagatgg acaaatatgt tttgtggaat attactgctg ccctgatgaa 1020 gaagttcctg aatctgagtc ttgagtatga caattcactg atatttatgt gtacatttat 1080 gatagatgaa gttcttattc tgagtacagt actctttgtc atttcatatt ggattttcta 1140 tagagaagaa gcacaatggg gaagatagga gcaaggtcat gtaccctaat agttactatg 1200 ttttgtaaat ccattttgta gagggcatgt aaataaatgt tttcctgtag tcat 1254 <210> 287 <211> 1620 <212> DNA <213> Homo sapiens <400> 287 aggtctgtgc cgcctccctc cggtctcggt ggcgcggcac gcgcggctct ctaggcctcc 60 ttcagctctg tggtgacggt ggccgaggtg gagggccggt ctgaagagtg gcgggactgg 120 cttcacttcc tccgcggttc ctcggagccg cctcgctcct cttcagggac tttgctgaga 180 agggctctcg ggcgtccaga ccccaccgca aaggtgtttg gcgatccgcc gagaagttgt 240 tggccccagg agcatccctc ggggccgaat gcgcagtgga cgatgcccct tctgacccaa 300 cagatccaag acgaggatga tcagtacagc cttgtggcca gccttgacaa cgttaggaat 360 ctctccacta tcttgaaagc tattcatttc cgagaacatg ccacgtgttt cgcaactaaa 420 aatggtatca aagtaacagt ggaaaatgca aagtgtgtgc aagcaaatgc ttttattcag 480 ggactttaac tgcacttcga atgtgttacc aaggttatgg ttaccctttg atgctgttcc 540 tggaagaagg aggagtggtg acagtctgca aaatcaatac acaggaacct gaggagaccc 600 tggactttga tttctgcagc accaatgtta ttaataaaat tattctgcag tcagaggggc 660 tccgtgaagc attttctgaa ttggatatga cgagtgaagt cctacaaatt accatgtctc 720 ctgacaagcc ttatttcagg ttatctactt ttggaaatgc aggaagttcc caccttgact 780 atcccaaaga ttctgatttg atggaagcat ttcattgtaa tcagacccaa gtcaacagat 840 acaagatttc cttactgaaa ccctctacaa aggcattagt cctatcttgt aaggtatcta 900 ttcggacaga taacagaggc ttcctttcat tacagtatat gattagaaat gaagatggac 960 aaatatgttt tgtggaatat tactgctgcc ctgatgaaga agttcctgaa tctgagtctt 1020 gagtatgaca attcactgat atttatgtgt acatttatga tagatgaagt tcttattctg 1080 agtacagtac tctttgtcat ttcatattgg attttctata gagaagaagc acaatgggga 1140 agataggagc aaggtcatgt accctaatag ttactatgtt ttgtaaatcc attttgtaga 1200 gggcatgtaa ataaatgttt tcctgtagtc atagattatt caggactgtc ctttagttct 1260 gtcttttgaa ctcatgggaa taattgtgag tcagcgtaac atttcaagag tctaaaggtg 1320 gccgggtgtg gtggctttaa tcccagcact ttgggaaccc gaggtgggcg gatcacctga 1380 ggtcaggagt tcgaaaccag cctgaccaac gtggagaaac cccatctcta ctaaaaatac 1440 aaaaaattag ccggacgtgg tggcacatgc ctgtaatgcc agctactcgg gaggctgagg 1500 caggaaaatt gcttgaaccc gggaggcgga ggttgtggtg agctgaaatg acgccattgc 1560 actccagcct aggcaataag agcaaaactc tgcctcaaaa aaaaaaaaaa aaaaaaaaaa 1620 <210> 288 <211> 1145 <212> DNA <213> Homo sapiens <400> 288 gtggagggcc ggtctgaaga gtggcgggac tggcttcact tcctccgcgg ttcctcggag 60 ccgcctcgct cctcttcagg gactttgctg agaagggctc tcgggcgtcc agaccccacc 120 gcaaaggtgt ttggcgatcc gccgagaagt tgttggcccc aggagcatcc ctcggggccg 180 aatgcgcagt ggacgatgcc ccttctgacc caacagatcc aagacgagga tgatcagtac 240 agccttgtgg ccagccttga caacgttagg aatctctcca ctatcttgaa agctattcat 300 ttccgagaac atgccacgtg tttcgcaact aaaaatggta tcaaagtaac agtggaaaat 360 gcaaagtgtg tgcaagcaaa tgcttttatt cagggacttt aactgcactt cgaatgtgtt 420 accaaggtta tggttaccct ttgatgctgt tcctggaaga aggaggagtg gtgacagtct 480 gcaaaatcaa tacacaggaa cctgaggaga ccctggactt tgatttctgc agcaccaatg 540 ttattaataa aattattctg cagtcagagg ggctccgtga agcattttct gaattggata 600 tgacgagtga agtcctacaa attaccatgt ctcctgacaa gccttatttc aggttatcta 660 cttttggaaa tgcaggaagt tcccaccttg actatcccaa agattctgat ttgatggaag 720 catttcattg taatcagacc caagtcaaca gatacaagat ttccttactg aaaccctcta 780 caaaggcatt agtcctatct tgtaaggtat ctattcggac agataacaga ggcttccttt 840 cattacagta tatgattaga aatgaagatg gacaaatatg ttttgtggaa tattactgct 900 gccctgatga agaagttcct gaatctgagt cttgagtatg acaattcact gatatttatg 960 tgtacattta tgatagatga agttcttatt ctgagtacag tactctttgt catttcatat 1020 tggattttct atagagaaga agcacaatgg ggaagatagg agcaaggtca tgtaccctaa 1080 tagttactat gttttgtaaa tccattttgt agagggcatg taaataaatg ttttcctgta 1140 gtcat 1145 <210> 289 <211> 1175 <212> DNA <213> Homo sapiens <400> 289 ggcacgaggg tggagggccg gtctgaagag tggcgggact ggcttcactt cctccgcggt 60 tcctcggagc cgcctcgctc ctcttcaggg actttgctga gaagggctct cgggcgtcca 120 gaccccaccg caaaggtgtt tggcgatccg ccgagaagtt gttggcccca ggagcatccc 180 tcggggccga atgcgcagtg gacgatgccc cttctgaccc aacagatcca agacgaggat 240 gatcagtaca gccttgtggc cagccttgac aacgttagga atctctccac tatcttgaaa 300 gctattcatt tccgagaaca tgccacgtgt ttcgcaacta aaaatggtat caaagtaaca 360 gtggaaaatg caaagtgtgt gcaagcaaat gcttttattc agggacttta actgcacttc 420 gaatgtgtta ccaaggttat ggttaccctt tgatgctgtt cctggaagaa ggaggagtgg 480 tgacagtctg caaaatcaat acacaggaac ctgaggagac cctggacttt gatttctgca 540 gcaccaatgt tattaataaa attattctgc agtcagaggg gctccgtgaa gcattttctg 600 aattggatat gacgagtgaa gtcctacaaa ttaccatgtc tcctgacaag ccttatttca 660 ggttatctac ttttggaaat gcaggaagtt cccaccttga ctatcccaaa gattctgatt 720 tgatggaagc atttcattgt aatcagaccc aagtcaacag atacaagatt tccttactga 780 aaccctctac aaaggcatta gtcctatctt gtaaggtatc tattcggaca gataacagag 840 gcttcctttc attacagtat atgattagaa atgaagatgg acaaatatgt tttgtggaat 900 attactgctg ccctgatgaa gaagttcctg aatctgagtc ttgagtatga caattcactg 960 atatttatgt gtacatttat gatagatgaa gttcttattc tgagtacagt actctttgtc 1020 atttcatatt ggattttcta tagagaagaa gcacaatggg gaagatagga gcaaggtcat 1080 gtaccctaat agttactatg ttttgtaaat ccattttgta gagggcatgt aaataaatgt 1140 tttcctgtag tcataaaaaa aaaaaaaaaa aaaaa 1175 <210> 290 <211> 740 <212> DNA <213> Homo sapiens <400> 290 atgccccttc tgacccaaca gatccaagac gaggatgatc agtacagcct tgtggccagc 60 cttgacaacg ttaggaatct ctccactatc ttgaaagcta ttcatttccg agaacatgcc 120 acgtgtttcg caactaaaaa tggtatcaaa gtaacagtgg aaaatgcaaa gtgtgtgcaa 180 gcaaatgctt ttattcaggg actttaactg cacttcgaat gtgttaccaa ggttatggtt 240 accctttgat gctgttcctg gaagaaggag gagtggtgac agtctgcaaa atcaatacac 300 aggaacctga ggagaccctg gactttgatt tctgcagcac caatgttatt aataaaatta 360 ttctgcagtc agaggggctc cgtgaagcat tttctgaatt ggatatgacg agtgaagtcc 420 tacaaattac catgtctcct gacaagcctt atttcaggtt atctactttt ggaaatgcag 480 gaagttccca ccttgactat cccaaagatt ctgatttgat ggaagcattt cattgtaatc 540 agacccaagt caacagatac aagatttcct tactgaaacc ctctacaaag gcattagtcc 600 tatcttgtaa ggtatctatt cggacagata acagaggctt cctttcatta cagtatatga 660 ttagaaatga agatggacaa atatgttttg tggaatatta ctgctgccct gatgaagaag 720 ttcctgaatc tgagtcttga 740 <210> 291 <211> 1134 <212> DNA <213> Homo sapiens <400> 291 gcttcacttc ctccgcggtt cctcggagcc gcctcgctcc tcttcaggga ctttgctgag 60 aagggctctc gggcgtccag accccaccgc aaaggtgttt ggcgatccgc cgagaagttg 120 ttggccccag gagcatccct cggggccgaa tgcgcagtgg acgatgcccc ttctgaccca 180 acagatccaa gacgaggatg atcagtacag ccttgtggcc agccttgaca acgttaggaa 240 tctctccact atcttgaaag ctattcattt ccgagaacat gccacgtgtt tcgcaactaa 300 aaatggtatc aaagtaacag tggaaaatgc aaagtgtgtg caagcaaatg cttttattca 360 gggactttaa ctgcacttcg aatgtgttac caaggttatg gttacccttt gatgctgttc 420 ctggaagaag gaggagtggt gacagtctgc aaaatcaata cacaggaacc tgaggagacc 480 ctggactttg atttctgcag caccaatgtt attaataaaa ttattctgca gtcagagggg 540 ctccgtgaag cattttctga attggatatg acgagtgaag tcctacaaat taccatgtct 600 cctgacaagc cttatttcag gttatctact tttggaaatg caggaagttc ccaccttgac 660 tatcccaaag attctgattt gatggaagca tttcattgta atcagaccca agtcaacaga 720 tacaagattt ccttactgaa accctctaca aaggcattag tcctatcttg taaggtatct 780 attcggacag ataacagagg cttcctttca ttacagtata tgattagaaa tgaagatgga 840 caaatatgtt ttgtggaata ttactgctgc cctgatgaag aagttcctga atctgagtct 900 tgagtatgac aattcactga tatttatgtg tacatttatg atagatgaag ttcttattct 960 gagtacagta ctctttgtca tttcatattg gattttctat agagaagaag cacaatgggg 1020 aagataggag caaggtcatg taccctaata gttactatgt tttgtaaatc cattttgtag 1080 agggcatgta aataaatgtt ttcctgtagt cataaaaaaa aaaaaaaaaa aaaa 1134 <210> 292 <211> 3124 <212> DNA <213> Homo sapiens <400> 292 ggatccgcgg tgcggctgtg ggtgagcggc gggctgcggg accctcgccc ggcggctcag 60 aaaggcggga agcgcacgca tttttctggc ttgtttcctg aacgttggcc ggcggaggac 120 ccgcgagctc gggagagcgc ccgggccggg ctctgcattc ttgttgcctc ttccctggcg 180 ggggtgatac tctcccgcgg ggcttgctgt gggggttcag ggaggtggag atgggcccgc 240 catgtgcctg cagggagcag gcgctgtggt taatactttt cttcttcgaa ccctcccaca 300 gctctttagg gtgagatctg ctgtaccagt ctcacaggag tcagcattgg taatagtgct 360 gtgctgcgga agagtggagt ctaaactttt tcattgccag tgccccgaaa ctggagtgtg 420 aaggaccgag acaagatgaa gactgtgctc atggttgctg aaaagccgtc cttggcacag 480 tcaattgcca aaatcctctc tagagggagc ctgtcctcac acaaagggct gaacggggcc 540 tgctcagtcc acgagtacac tgggaccttt gctggccagc cagtgcgctt caagatgacg 600 tctgtctgtg gtcacgtgat gaccctggat ttcctgggaa aatacaacaa atgggacaaa 660 gtggaccccg cagaactgtt cagccaagct cccacggaga agaaagaagc taaccccaag 720 ctgaacatgg tgaagttcct gcaggtggag ggcagaggct gcgactacat cgtgctgtgg 780 ctggactgcg acaaggaggg ggagaacatc tgctttgagg ttcttgatgc tgttctgccc 840 gtcatgaaca aggcccatgg tggcgagaag accgtgttcc gggccaggtt tagctccatc 900 acggacacag acatctgtaa tgccatggcc tgcctaggcg agcctgacca caacgaggcg 960 ctctcagtgg atgctcgcca ggagctggac ctgcgaatcg gctgtgcatt caccaggttt 1020 cagactaaat atttccaggg gaaatacggt gatttagaca gctctctcat ctcctttggg 1080 ccgtgtcaga ctccaaccct gggattctgt gtggagagac atgataaaat ccagtccttc 1140 aaaccagaga cctactgggt gctgcaggcc aaggttaaca ctgacaaaga cagatctctc 1200 cttttggact gggaccgagt aagagtgttt gaccgggaga tcgcacagat gtttttaaac 1260 atgacaaagc tggagaagga agcccaggtg gaggccacaa gcaggaaaga aaaggccaag 1320 cagaggcccc tggccctgaa cactgtggag atgctgcgtg tggccagctc ttctctgggc 1380 atggggccgc agcacgccat gcagacggct gagcggctct acacgcaagg ctacatcagc 1440 tacccacgga cagagaccac ccactaccct gagaactttg acctgaaggg ctctctgcgg 1500 cagcaggcca accaccccta ctgggccgac acggtgaagc ggttgttagc agaaggtatc 1560 aaccgcccgc ggaaaggcca tgacgccggc gaccatcccc ccatcacccc catgaagtct 1620 gccacagagg ccgaattagg gggtgacgcg tggcggctct atgagtacat caccagacac 1680 ttcatcgcca cggtcagcca tgactgcaag tacctgcaga gcaccatctc cttcagaatt 1740 gggcccgagc tcttcacctg ctccgggaag accgtcctct caccaggctt cacggaggtc 1800 atgccctggc agagcgtgcc cctggaggag agcctgccca cttgccagcg gggtgatgcc 1860 ttccctgtgg gcgaggtgaa gatgctggag aagcagacga acccacccga ctacctgacg 1920 gaggccgagc tcatcacgct catggagaag catggcatcg gcacggatgc cagcatccct 1980 gtgcatatca acaacatctg ccagcgcaac tatgtcacgg tggagagcgg gcgccggctc 2040 aagcccacca acctcggcat cgtcctggtg cacggctact ataagattga tgcagagctg 2100 gtgctcccca ccatccgcag tgcagtggag aagcagctga acctgatcgc ccagggcaag 2160 gccgactacc gccaggtcct gggccacacc ctggacgtgt tcaagaggaa gttccactac 2220 tttgtcgact ccattgctgg catggatgag ttgatggagg tgtctttctc gcccctggcg 2280 gccacaggca agcccctctc acgctgtggg aagtgccacc gcttcatgaa gtacatccag 2340 gccaagccaa gccgcctgca ctgctcccac tgcgatgaga cctacacgct cccccagaac 2400 ggcaccatca agctctacaa ggagctccgc tgccctctgg atgacttcga gctggtcctg 2460 tggtcatcag gctctcgggg caagagctac ccgctgtgcc cctactgcta caaccaccca 2520 cccttccgag acatgaagaa aggcatgggc tgcaacgagt gtacgcaccc ctcctgccag 2580 cactcgctga gcatgctggg catcggccag tgcgtggaat gtgagagcgg ggtgctggtg 2640 ctggacccca cctcgggccc caagtggaag gtggcctgca acaagtgcaa cgtggtagcg 2700 cactgcttcg agaacgccca ccgcgtgcgg gtgtccgccg acacctgcag tgtctgtgag 2760 gccgccttgc ttgatgtgga cttcaacaag gccaagtccc cactcccggg cgatgagacg 2820 cagcacatgg gctgcgtctt ttgtgacccc gtcttccagg agctggtgga gctgaagcat 2880 gcggcctcct gccaccccat gcaccgcggt ggaccaggga gaaggcaggg tcgagggcgg 2940 ggccgggcca ggaggccccc tgggaagccc aaccccagac ggcccaagga caagatgtca 3000 gccctggccg cctactttgt atgatgaccc tgtcctccct cacccaggct gcagtgccat 3060 gcagacacct catggcactt caaactatta aaatgcattt tatcttaaaa aaaaaaaaaa 3120 aaaa 3124 <210> 293 <211> 2793 <212> DNA <213> Homo sapiens <400> 293 gcggtgcggc tgtgggagtc agcattggta atagtgctgt gctgcggaag agtggagtct 60 aaactttttc attgccagtg ccccgaaact ggagtgtgaa ggaccgagac aagatgaaga 120 ctgtgctcat ggttgctgaa aagccgtcct tggcacagtc aattgccaaa atcctctcta 180 gagggagcct gtcctcacac aaagggctga acggggcctg ctcagtccac gagtacactg 240 ggacctttgc tggccagcca gtgcgcttca agatgacgtc tgtctgtggt cacgtgatga 300 ccctggattt cctgggaaaa tacaacaaat gggacaaagt ggaccccgca gaactgttca 360 gccaagctcc cacggagaag aaagaagcta accccaagct gaacatggtg aagttcctgc 420 aggtggaggg cagaggctgc gactacatcg tgctgtggct ggactgcgac aaggaggggg 480 agaacatctg ctttgaggtt cttgatgctg ttctgcccgt catgaacaag gcccatggtg 540 gcgagaagac cgtgttccgg gccaggttta gctccatcac ggacacagac atctgtaatg 600 ccatggcctg cctaggcgag cctgaccaca acgaggcgct ctcagtggat gctcgccagg 660 agctggacct gcgaatcggc tgtgcattca ccaggtttca gactaaatat ttccagggga 720 aatacggtga tttagacagc tctctcatct cctttgggcc gtgtcagact ccaaccctgg 780 gattctgtgt ggagagacat gataaaatcc agtccttcaa accagagacc tactgggtgc 840 tgcaggccaa ggttaacact gacaaagaca gatctctcct tttggactgg gaccgagtaa 900 gagtgtttga ccgggagatc gcacagatgt ttttaaacat gacaaagctg gagaaggaag 960 cccaggtgga ggccacaagc aggaaagaaa aggccaagca gaggcccctg gccctgaaca 1020 ctgtggagat gctgcgtgtg gccagctctt ctctgggcat ggggccgcag cacgccatgc 1080 agacggctga gcggctctac acgcaaggct acatcagcta cccacggaca gagaccaccc 1140 actaccctga gaactttgac ctgaagggct ctctgcggca gcaggccaac cacccctact 1200 gggccgacac ggtgaagcgg ttgttagcag aaggtatcaa ccgcccgcgg aaaggccatg 1260 acgccggcga ccatcccccc atcaccccca tgaagtctgc cacagaggcc gaattagggg 1320 gtgacgcgtg gcggctctat gagtacatca ccagacactt catcgccacg gtcagccatg 1380 actgcaagta cctgcagagc accatctcct tcagaattgg gcccgagctc ttcacctgct 1440 ccgggaagac cgtcctctca ccaggcttca cggaggtcat gccctggcag agcgtgcccc 1500 tggaggagag cctgcccact tgccagcggg gtgatgcctt ccctgtgggc gaggtgaaga 1560 tgctggagaa gcagacgaac ccacccgact acctgacgga ggccgagctc atcacgctca 1620 tggagaagca tggcatcggc acggatgcca gcatccctgt gcatatcaac aacatctgcc 1680 agcgcaacta tgtcacggtg gagagcgggc gccggctcaa gcccaccaac ctcggcatcg 1740 tcctggtgca cggctactat aagattgatg cagagctggt gctccccacc atccgcagtg 1800 cagtggagaa gcagctgaac ctgatcgccc agggcaaggc cgactaccgc caggtcctgg 1860 gccacaccct ggacgtgttc aagaggaagt tccactactt tgtcgactcc attgctggca 1920 tggatgagtt gatggaggtg tctttctcgc ccctggcggc cacaggcaag cccctctcac 1980 gctgtgggaa gtgccaccgc ttcatgaagt acatccaggc caagccaagc cgcctgcact 2040 gctcccactg cgatgagacc tacacgctcc cccagaacgg caccatcaag ctctacaagg 2100 agctccgctg ccctctggat gacttcgagc tggtcctgtg gtcatcaggc tctcggggca 2160 agagctaccc gctgtgcccc tactgctaca accacccacc cttccgagac atgaagaaag 2220 gcatgggctg caacgagtgt acgcacccct cctgccagca ctcgctgagc atgctgggca 2280 tcggccagtg cgtggaatgt gagagcgggg tgctggtgct ggaccccacc tcgggcccca 2340 agtggaaggt ggcctgcaac aagtgcaacg tggtagcgca ctgcttcgag aacgcccacc 2400 gcgtgcgggt gtccgccgac acctgcagtg tctgtgaggc cgccttgctt gatgtggact 2460 tcaacaaggc caagtcccca ctcccgggcg atgagacgca gcacatgggc tgcgtctttt 2520 gtgaccccgt cttccaggag ctggtggagc tgaagcatgc ggcctcctgc caccccatgc 2580 accgcggtgg accagggaga aggcagggtc gagggcgggg ccgggccagg aggccccctg 2640 ggaagcccaa ccccagacgg cccaaggaca agatgtcagc cctggccgcc tactttgtat 2700 gatgaccctg tcctccctca cccaggctgc agtgccatgc agacacctca tggcacttca 2760 aactattaaa atgcatttta tcttaaaaaa aaa 2793 <210> 294 <211> 2784 <212> DNA <213> Homo sapiens <400> 294 gcggtgcggc tgtgggagtc agcattggta atagtgctgt gctgcggaag agtggagtct 60 aaactttttc attgccagtg ccccgaaact ggagtgtgaa ggaccgagac aagatgaaga 120 ctgtgctcat ggttgctgaa aagccgtcct tggcacagtc aattgccaaa atcctctcta 180 gagggagcct gtcctcacac aaagggctga acggggcctg ctcagtccac gagtacactg 240 ggacctttgc tggccagcca gtgcgcttca agatgacgtc tgtctgtggt cacgtgatga 300 ccctggattt cctgggaaaa tacaacaaat gggacaaagt ggaccccgca gaactgttca 360 gccaagctcc cacggagaag aaagaagcta accccaagct gaacatggtg aagttcctgc 420 aggtggaggg cagaggctgc gactacatcg tgctgtggct ggactgcgac aaggaggggg 480 agaacatctg ctttgaggtt cttgatgctg ttctgcccgt catgaacaag gcccatggtg 540 gcgagaagac cgtgttccgg gccaggttta gctccatcac ggacacagac atctgtaatg 600 ccatggcctg cctaggcgag cctgaccaca acgaggcgct ctcagtggat gctcgccagg 660 agctggacct gcgaatcggc tgtgcattca ccaggtttca gactaaatat ttccagggga 720 aatacggtga tttagacagc tctctcatct cctttgggcc gtgtcagact ccaaccctgg 780 gattctgtgt ggagagacat gataaaatcc agtccttcaa accagagacc tactgggtgc 840 tgcaggccaa ggttaacact gacaaagaca gatctctcct tttggactgg gaccgagtaa 900 gagtgtttga ccgggagatc gcacagatgt ttttaaacat gacaaagctg gagaaggaag 960 cccaggtgga ggccacaagc aggaaagaaa aggccaagca gaggcccctg gccctgaaca 1020 ctgtggagat gctgcgtgtg gccagctctt ctctgggcat ggggccgcag cacgccatgc 1080 agacggctga gcggctctac acgcaaggct acatcagcta cccacggaca gagaccaccc 1140 actaccctga gaactttgac ctgaagggct ctctgcggca gcaggccaac cacccctact 1200 gggccgacac ggtgaagcgg ttgttagcag aaggtatcaa ccgcccgcgg aaaggccatg 1260 acgccggcga ccatcccccc atcaccccca tgaagtctgc cacagaggcc gaattagggg 1320 gtgacgcgtg gcggctctat gagtacatca ccagacactt catcgccacg gtcagccatg 1380 actgcaagta cctgcagagc accatctcct tcagaattgg gcccgagctc ttcacctgct 1440 ccgggaagac cgtcctctca ccaggcttca cggaggtcat gccctggcag agcgtgcccc 1500 tggaggagag cctgcccact tgccagcggg gtgatgcctt ccctgtgggc gaggtgaaga 1560 tgctggagaa gcagacgaac ccacccgact acctgacgga ggccgagctc atcacgctca 1620 tggagaagca tggcatcggc acggatgcca gcatccctgt gcatatcaac aacatctgcc 1680 agcgcaacta tgtcacggtg gagagcgggc gccggctcaa gcccaccaac ctcggcatcg 1740 tcctggtgca cggctactat aagattgatg cagagctggt gctccccacc atccgcagtg 1800 cagtggagaa gcagctgaac ctgatcgccc agggcaaggc cgactaccgc caggtcctgg 1860 gccacaccct ggacgtgttc aagaggaagt tccactactt tgtcgactcc attgctggca 1920 tggatgagtt gatggaggtg tctttctcgc ccctggcggc cacaggcaag cccctctcac 1980 gctgtgggaa gtgccaccgc ttcatgaagt acatccaggc caagccaagc cgcctgcact 2040 gctcccactg cgatgagacc tacacgctcc cccagaacgg caccatcaag ctctacaagg 2100 agctccgctg ccctctggat gacttcgagc tggtcctgtg gtcatcaggc tctcggggca 2160 agagctaccc gctgtgcccc tactgctaca accacccacc cttccgagac atgaagaaag 2220 gcatgggctg caacgagtgt acgcacccct cctgccagca ctcgctgagc atgctgggca 2280 tcggccagtg cgtggaatgt gagagcgggg tgctggtgct ggaccccacc tcgggcccca 2340 agtggaaggt ggcctgcaac aagtgcaacg tggtagcgca ctgcttcgag aacgcccacc 2400 gcgtgcgggt gtccgccgac acctgcagtg tctgtgaggc cgccttgctt gatgtggact 2460 tcaacaaggc caagtcccca ctcccgggcg atgagacgca gcacatgggc tgcgtctttt 2520 gtgaccccgt cttccaggag ctggtggagc tgaagcatgc ggcctcctgc caccccatgc 2580 accgcggtgg accagggaga aggcagggtc gagggcgggg ccgggccagg aggccccctg 2640 ggaagcccaa ccccagacgg cccaaggaca agatgtcagc cctggccgcc tactttgtat 2700 gatgaccctg tcctccctca cccaggctgc agtgccatgc agacacctca tggcacttca 2760 aactattaaa atgcatttta tctt 2784 <210> 295 <211> 2680 <212> DNA <213> Homo sapiens <400> 295 gctgcggaag agtggagtct aaactttttc attgccagtg ccccgaaact ggagtgtgaa 60 ggaccgagac aagatgaaga ctgtgctcat ggttgctgaa aagccgtcct tggcacagtc 120 aattgccaaa atcctctcta gagggagcct gtcctcacac aaagggctga acggggcctg 180 ctcagtccac gagtacactg ggacctttgc tggccagcca gtgcgcttca agatgacgtc 240 tgtctgtggt cacgtgatga ccctggattt cctgggaaaa tacaacaaat gggacaaagt 300 ggaccccgca gaactgttca gccaagctcc cacggagaag aaagaagcta accccaagct 360 gaacatggtg aagttcctgc aggtggaggg cagaggctgc gactacatcg tgctgtggct 420 ggactgcgac aaggaggggg agaacatctg ctttgaggtt cttgatgctg ttctgcccgt 480 catgaacaag gcccatggtg gcgagaagac cgtgttccgg gccaggttta gctccatcac 540 ggacacagac atctgtaatg ccatggcctg cctaggcgag cctgaccaca acgaggcgct 600 ctcagtggat gctcgccagg agctggacct gcgaatcggc tgtgcattca ccaggtttca 660 gactaaatat ttccagggga aatacggtga tttagacagc tctctcatct cctttgggcc 720 gtgtcaaact ccaaccctgg gattctgtgt ggagagacat gataaaatcc agtccttcaa 780 accagagacc tactgggtgc tgcaggccaa ggttaacact gacaaagaca gatctctcct 840 tttggactgg gaccgagtaa gagtgtttga ccgggagatc gcacagatgt ttttaaacat 900 gacaaagctg gagaaggaag cccaggtgga ggccacaagc aggaaagaaa aggccaagca 960 gaggcccctg gccctgaaca ctgtggagat gctgcgtgtg gccagctctt ctctgggcat 1020 ggggccgcag cacgccatgc agacggctga gcggctctac acgcaaggct acatcagcta 1080 cccacggaca gagaccaccc actaccctga gaactttgac ctgaagggct ctctgcggca 1140 gcaggccaac cacccctact gggccgacac ggtgaagcgg ttgttagcag aaggtatcaa 1200 ccgcccgcgg aaaggccatg acgccggcga ccatcccccc atcaccccca tgaagtctgc 1260 cacagaggcc gaattagggg gtgacgcgtg gcggctctat gagtacatca ccagacactt 1320 catcgccacg gtcagccatg actgcaagta cctgcagagc accatctcct tcagaattgg 1380 gcccgagctc ttcacctgct ccgggaagac cgtcctctca ccaggcttca cggaggtcat 1440 gccctggcag agcgtgcccc tggaggagag cctgcccact tgccagcggg gtgatgcctt 1500 ccctgtgggc gaggtgaaga tgctggagaa gcagacgaac ccacccgact acctgacgga 1560 ggccgagctc atcacgctca tggagaagca tggcatcggc acggatgcca gcatccctgt 1620 gcatatcaac aacatctgcc agcgcaacta tgtcacggtg gagagcgggc gccggctcaa 1680 gcccaccaac ctcggcatcg tcctggtgca cggctactat aagattgatg cagagctggt 1740 gctccccacc atccgcagtg cagtggagaa gcagctgaac ctgatcgccc agggcaaggc 1800 cgactaccgc caggtcctgg gccacaccct ggacgtgttc aagaggaagt tccactactt 1860 tgtcgactcc attgctggca tggatgagtt gatggaggtg tctttctcgc ccctggcggc 1920 cacaggcaag cccctctcac gctgtgggaa gtgccaccgc ttcatgaagt acatccaggc 1980 caagccaagc cgcctgcact gctcccactg cgatgagacc tacacgctcc cccagaacgg 2040 caccatcaag ctctacaagg agctccgctg ccctctggat gacttcgagc tggtcctgtg 2100 gtcatcaggc tctcggggca agagctaccc gctgtgcccc tactgctaca accacccacc 2160 cttccgagac atgaagaaag gcatgggctg caacgagtgt acgcacccct cctgccagca 2220 ctcgctgagc atgctgggca tcggccagtg cgtggaatgt gagagcgggg tgctggtgct 2280 ggaccccacc tcgggcccca agtggaaggt ggcctgcaac aagtgcaacg tggtagcgca 2340 ctgcttcgag aacgcccacc gcgtgcgggt gtccgccgac acctgcagtg tctgtgaggc 2400 cgccttgctt gatgtggact tcaacaaggc caagtcccca ctcccgggcg atgagacgca 2460 gcacatgggc tgcgtctttt gtgaccccgt cttccaggag ctggtggagc tgaagcatgc 2520 ggcctcctgc caccccatgc accgcggtgg accagggaga aggcagggtc gagggcgggg 2580 ccgggccagg aggccccctg ggaagcccaa ccccagacgg cccaaggaca agatgtcagc 2640 cctggccgcc tactttgtat gatgaccctg tcctccctca 2680 <210> 296 <211> 3124 <212> DNA <213> Homo sapiens <400> 296 ggatccgcgg tgcggctgtg ggtgagcggc gggctgcggg accctcgccc ggcggctcag 60 aaaggcggga agcgcacgca tttttctggc ttgtttcctg aacgttggcc ggcggaggac 120 ccgcgagctc gggagagcgc ccgggccggg ctctgcattc ttgttgcctc ttccctggcg 180 ggggtgatac tctcccgcgg ggcttgctgt gggggttcag ggaggtggag atgggcccgc 240 catgtgcctg cagggagcag gcgctgtggt taatactttt cttcttcgaa ccctcccaca 300 gctctttagg gtgagatctg ctgtaccagt ctcacaggag tcagcattgg taatagtgct 360 gtgctgcgga agagtggagt ctaaactttt tcattgccag tgccccgaac ctggagtgtg 420 aaggaccgag acaagatgaa gactgtgctc atggttgctg aaaagccgtc cttggcacag 480 tcaattgcca aaatcctctc tagagggagc ctgtcctcac acaaagggct gaacggggcc 540 tgctcagtcc acgagtacac tgggaccttt gctggccagc cagtgcgctt caagatgacg 600 tctgtctgtg gtcacgtgat gaccctggat ttcctgggaa aatacaacaa atgggacaaa 660 gtggaccccg cagaactgtt cagccaagct cccacggaga agaaagaagc taaccccaag 720 ctgaacatgg tgaagttcct gcaggtggag ggcagaggct gcgactacat cgtgctgtgg 780 ctggactgcg acaaggaggg ggagaacatc tgctttgagg ttcttgatgc tgttctgccc 840 gtcatgaaca aggcccatgg tggcgagaag accgtgttcc gggccaggtt tagctccatc 900 acggacacag acatctgtaa tgccatggcc tgcctaggcg agcctgacca caacgaggcg 960 ctctcagtgg atgctcgcca ggagctggac ctgcgaatcg gctgtgcatt caccaggttt 1020 cagactaaat atttccaggg gaaatacggt gatttagaca gctctctcat ctcctttggg 1080 ccgtgtcaga ctccaaccct gggattctgt gtggagagac atgataaaat ccagtccttc 1140 aaaccagaga cctactgggt gctgcaggcc aaggttaaca ctgacaaaga cagatctctc 1200 cttttggact gggaccgagt aagagtgttt gaccgggaga tcgcacagat gtttttaaac 1260 atgacaaagc tggagaagga agcccaggtg gaggccacaa gcaggaaaga aaaggccaag 1320 cagaggcccc tggccctgaa cactgtggag atgctgcgtg tggccagctc ttctctgggc 1380 atggggccgc agcatgccat gcagacggct gagcggctct acacgcaagg ctacatcagc 1440 tacccacgga cagagaccac ccactaccct gagaactttg acctgaaggg ctctctgcgg 1500 cagcaggcca accaccccta ctgggccaac acggtgaagc ggttgttagc agaaggtatc 1560 aaccgcccgc ggaaaggcca tgacgccggc gaccatcccc ccatcacccc catgaagtct 1620 gccacagagg ccgaattagg gggtgacgcg tggcggctct atgagtacat caccagacac 1680 ttcatcgcca cggtcagcca tgactgcaag tacctgcaga gcaccatctc cttcagaatt 1740 gggcccgagc tcttcacctg ctccgggaag accgtcctct caccaggctt cacggaggtc 1800 atgccctggc agagcgtgcc cctggaggag agcctgccca cttgccagcg gggtgatgcc 1860 ttccctgtgg gcgaggtgaa gatgctggag aagcagacga acccacccga ctacctgacg 1920 gaggccgagc tcatcacgct catggagaag catggcatcg gcacggatgc cagcatccct 1980 gtgcatatca acaacatctg ccagcgcaac tatgtcacgg tggagagcgg gcgccggctc 2040 aagcccacca acctcggcat cgtcctggtg cacggctact ataagattga tgcagagctg 2100 gtgctcccca ccatccgcag tgcagtggag aagcagctga acctgatcgc ccagggcaag 2160 gccgactacc gccaggtcct gggccacacc ctggacgtgt tcaagaggaa gttccactac 2220 tttgtcgact ccattgctgg catggatgag ttgatggagg tgtctttctc gcccctggcg 2280 gccacaggca agcccctctc acgctgtggg aagtgccacc gcttcatgaa gtacatccag 2340 gccaagccaa gccgcctgca ctgctcccac tgcgatgaga cctacacgct cccccagaac 2400 ggcaccatca agctctacaa ggagctccgc tgccctctgg atgacttcga gctggtcctg 2460 tggtcatcag gctctcgggg caagagctac ccgctgtgcc cctactgcta caaccaccca 2520 cccttccgag acatgaagaa aggcatgggc tgcaacgagt gtacgcaccc ctcctgccag 2580 cactcgctga gcatgctggg catcggccag tgcgtggaat gtgagagcgg ggtgctggtg 2640 ctggacccca cctcgggccc caagtggaag gtggcctgca acaagtgcaa cgtggtagcg 2700 cactgcttcg agaacgccca ccgcgtgcgg gtgtccgccg acacctgcag tgtctgtgag 2760 gccgccttgc ttgatgtgga cttcaacaag gccaagtccc cactcccggg cgatgagacg 2820 cagcacatgg gctgcgtctt ttgtgacccc gtcttccagg agctggtgga gctgaagcat 2880 gcggcctcct gccaccccat gcaccgcggt ggaccaggga gaaggcaggg tcgagggcgg 2940 ggccgggcca ggaggccccc tgggaagccc aaccccagac ggcccaagga caagatgtca 3000 gccctggccg cctactttgt atgatgaccc tgtcctccct cacccaggct gcagtgccat 3060 gcagacacct catggcactt caaactatta aaatgcattt tatcttaaaa aaaaaaaaaa 3120 aaaa 3124 <210> 297 <211> 4182 <212> DNA <213> Homo sapiens <400> 297 gggggttgtc ggtagccgcc ccgggaacaa ggaccggagc tggatccgcg gtgcggctgt 60 gggagtcagc attggtaata gtgctgtgct gcggaagagt ggagtctaaa ctttttcatt 120 gccagtgccc cgaaactgga gtgtgaagga ccgagacaaa atgaagactg tgctcatggt 180 tgctgaaaag ccgtccttgg cacagtcaat tgccaaaatc ctctctagag ggagcctgtc 240 ctcacacaaa gggctgaacg gggcctgctc agtccacgag tacactggga cctttgctgg 300 ccagccagtg cgcttcaaga tgacgtctgt ctgtggtcac gtgatgaccc tggatttcct 360 gggaaaatac aacaaatggg acaaagtgga ccccgcagaa ctgttcagcc aagctcccac 420 ggagaagaaa gaagctaacc ccaagctgaa catggtgaag ttcctgcagg tggagggcag 480 aggctgcgac tacatcgtgc tgtggctgga ctgcgacaag gagggggaga acatctgctt 540 tgagaaatga agccacttat tcccagtaag gaagctgcgt ggccaggctc cggcggcgac 600 cctagtccca ctgcacggcc ttcctagttc ttgatgctgt tctgcccgtc atgaacaagg 660 cccatggtgg cgagaagacc gtgttccggg ccaggtttag ctccatcacg gacacagaca 720 tctgtaatgc catggcctgc ctaggcgagc ctgaccacaa cgaggcgctc tcagtggatg 780 ctcgccagga gctggacctg cgaatcggct gtgcattcac caggtttcag actaaatatt 840 tccaggggaa atacggtgat ttagacagct ctctcatctc ctttgggccg tgtcagactc 900 caaccctggg attctgtgtg gagagacatg ataaaatcca gtccttcaaa ccagagacct 960 actgggtgct gcaggccaag gttaacactg acaaagacag atctctcctt ttggactggg 1020 accgagtaag agtgtttgac cgggagatcg cacagatgtt tttaaacatg acaaagctgg 1080 agaaggaagc ccaggtggag gccacaagca ggaaagaaaa ggccaagcag aggcccctgg 1140 ccctgaacac tgtggagatg ctgcgtgtgg ccagctcttc tctgggcatg gggccgcagc 1200 acgccatgca gacggctgag cggctctaca cgcaaggcta catcagctac ccacggacag 1260 agaccaccca ctaccctgag aactttgacc tgaagggctc tctgcggcag caggccaacc 1320 acccctactg ggccgacacg gtgaagcggt tgttagcaga aggtatcaac cgcccgcgga 1380 aaggccatga cgccggcgac catcccccca tcacccccat gaagtctgcc acagaggccg 1440 aattaggggg tgacgcgtgg cggctctatg agtacatcac cagacacttc atcgccacgg 1500 tcagccatga ctgcaagtac ctgcagagca ccatctcctt cagaattggg cccgagctct 1560 tcacctgctc cgggaagacc gtcctctcac caggcttcac ggaggtcatg ccctggcaga 1620 gcgtgcccct ggaggagagc ctgcccactt gccagcgggg tgatgccttc cctgtgggcg 1680 aggtgaagat gctggagaag cagacgaacc cacccgacta cctgacggag gccgagctca 1740 tcacgctcat ggagaagcat ggcatcggca cggatgccag catccctgtg catatcaaca 1800 acatctgcca gcgcaactat gtcacggtgg agagcgggcg ccggctcaag cccaccaacc 1860 tcggcatcgt cctggtgcac ggctactata agattgatgc agagctggtg ctccccacca 1920 tccgcagtgc agtggagaag cagctgaacc tgatcgccca gggcaaggcc gactaccgcc 1980 aggtcctggg ccacaccctg gacgtgttca agaggaagtt ccactacttt gtcgactcca 2040 ttgctggtag agtctgcctc tggcctgccc ctcaccagag gggtgtctct ctgtcagcaa 2100 ggccagtacc tggggaccca ggtccccacg tgggaccagc tcccagatct gggcttcagg 2160 cctccgtagg ccaggtcagt gacacctcct ggctgggttg aaagagcagg tgcattaaca 2220 ccacacatgg ccaggaacac gtgcctctga cgcacagggc tgctgccctg ccgtgctgcc 2280 aggacagtag aaaccaccgc ctatagggac cctttcacac tcagaccctt gaccacgtgt 2340 tgcggagcct tttgctgggg actgggaggg agatgactcc tgcactctgc ttgcccgcag 2400 gcatggatga gttgatggag gtgtctttct cgcccctggc ggccacaggc aagcccctct 2460 cacgctgtgg gaagtgccac cgcttcatga agtacatcca ggccaagcca agccgcctgc 2520 actgctccca ctgcgatgag acctacacgc tcccccagaa cggcaccatc aagctctaca 2580 aggagctccg ctgccctctg gatgacttcg agctggtcct gtggtcatca ggctctcggg 2640 gcaagagcta cccgctgtgc ccctactgct acaaccaccc acccttccga gacatgaaga 2700 aaggtgagtg cagccactcc ctcctgtcca caggtagctg cagtctcttt tcagtgccaa 2760 cccctgcctt gcaccaggct ggactctgag gggacccctc accctggcct ttcctgcact 2820 cattggcact gagacgagag accctggatg tagctggggc actgcttagg cctcagccag 2880 tggtgccacc ctctctctgt gtcagaatcg agcaggcaac cctagtccac cctcaggacc 2940 tgggcacagg tgtgcagtgc tccctctgga gctgagtgag caagaggatg cagcagtcgg 3000 gggacccacc cggtgagcgg gcacccccag tcagcgtcca ccaccgtcct ccatcctcat 3060 cctcgtcctc attactggag gagggagcgc atgtccaggc aggcaggaca gagcaccgag 3120 ccagaccagg aatcagcggg agtgaggcat ctgcccacat tcaccgtgtg ctctgcagaa 3180 agctccctca ggcctcagtc tgcacccagg ctgccccggg agtgagaccc catccctgcc 3240 ctcctgctgc cgccagagta gctgacaggg tggttccatg tggcccagtg acatgagggt 3300 catgtggcat taccagtaac aagctggcag caaagcaaag gggggatgga gtcagctgaa 3360 acccactggg atggtgccag cgaggggcct tgaaagttga ggaggtttca ggtaagcaga 3420 aaacaggggt aatggcagcc aggagccgaa acatgagcaa ggctgtcccc aagagcaagg 3480 ccaagaagag ttccttctgc tgggacgagg gatccaggag cttgaggcat tgggagcagg 3540 cagcagaggg caggtgggca cagtgggcgt gcctttacag ggctcccttc tcccgccagg 3600 catgggctgc aacgagtgta cgcacccctc ctgccagcac tcgctgagca tgctgggcat 3660 cggccagtgc gtggaatgtg agagcggggt gctggtgctg gaccccacct cgggccccaa 3720 gtggaaggtg gcctgcaaca agtgcaacgt ggtagcgcac tgcttcgaga acgcccaccg 3780 cgtgcgggtg tccgccgaca cctgcagtgt ctgtgaggcc gccttgcttg atgtggactt 3840 caacaaggcc aagtccccac tcccgggcga tgagacgcag cacatgggct gcgtcttttg 3900 tgaccccgtc ttccaggagc tggtggagct gaagcatgcg gcctcctgcc accccatgca 3960 ccgcggtgga ccagggagaa ggcagggtcg agggcggggc cgggccagga ggccccctgg 4020 gaagcccaac cccagacggc ccaaggacaa gatgtcagcc ctggccgcct actttgtatg 4080 atgaccctgt cctccctcac ccaggctgca gtgccatgca gacacctcat ggcacttcaa 4140 actattaaaa tgcattttat cttaaaaaaa aaaaaaaaaa aa 4182 <210> 298 <211> 2889 <212> DNA <213> Homo sapiens <400> 298 atcgcacaga tgtttttaaa catgacaaag ctggagaagg aagcccaggt ggaggccaca 60 agcaggaaag aaaaggccaa gcagaggccc ctggccctga acactgtgga gatgctgcgt 120 gtggccagct cttctctggg catggggccg cagcacgcca tgcagacggc tgagcggctc 180 tacacgcaag gctacatcag ctacccacgg acagagacca cccactaccc tgagaacttt 240 gacctgaagg gctctctgcg gcagcaggcc aaccacccct actgggccga cacggtgaag 300 cggttgttag cagaaggtat caaccgcccg cggaaaggcc atgacgccgg cgaccatccc 360 cccatcaccc ccatgaagtc tgccacagag gccgaattag gatttgcagt gtgtcctgca 420 cagcggctct gtaagcagga gcttgctgct cgagcgagag tactgggggc tcctcacggc 480 cagagccccc agctggctcc caactgacta gccctggcct gttgcagggg gtgacgcgtg 540 gcggctctat gagtacatca ccagacactt catcgccacg gtcagccatg actgcaagta 600 cctgcagagc accatctcct tcagaattgg gcccgagctc ttcacctgct ccgggaagac 660 cgtcctctca ccaggcttca cggaggtcat gccctggcag agcgtgcccc tggaggagag 720 cctgcccact tgccagcggg gtgatgcctt ccctgtgggc gaggtgaaga tgctggagaa 780 gcagacgaac ccacccgact acctgacgga ggccgagctc atcacgctca tggagaagca 840 tggcatcggc acggatgcca gcatccctgt gcatatcaac aacatctgcc agcgcaacta 900 tgtcacggtg gagagcgggc gccggctcaa gcccaccaac ctcggcatcg tcctggtgca 960 cggctactat aagattgatg cagagctggt gctccccacc atccgcagtg cagtggagaa 1020 gcagctgaac ctgatcgccc agggcaaggc cgactaccgc caggtcctgg gccacaccct 1080 ggacgtgttc aagaggaagt tccactactt tgtcgactcc attgctggca tggatgagtt 1140 gatggaggtg tctttctcgc ccctggcggc cacaggcaag cccctctcac gctgtgggaa 1200 gtgccaccgc ttcatgaagt acatccaggc caagccaagc cgcctgcact gctcccactg 1260 cgatgagacc tacacgctcc cccagaacgg caccatcaag ctctacaagg agctccgctg 1320 ccctctggat gacttcgagc tggtcctgtg gtcatcaggc tctcggggca agagctaccc 1380 gctgtgcccc tactgctaca accacccacc cttccgagac atgaagaaag gtgagtgcag 1440 ccactccctc ctgtccacag gtagctgcag tctcttttca gtgccaaccc ctgccttgca 1500 ccaggctgga ctctgagggg acccctcacc ctggcctttc ctgcactcat tggcactgag 1560 acgagagacc ctggatgtag ctggggcact gcttaggcct cagccagtgg tgccaccctc 1620 tctctgtgtc agaatcgagc aggcaaccct agtccaccct caggacctgg gcacaggtgt 1680 gcagtgctcc ctctggagct gagtgagcaa gaggatgcag cagtcggggg acccacccgg 1740 tgagcgggca cccccagtca gcgtccacca ccgtcctcca tcctcatcct cgtcctcatt 1800 actggaggag ggagcgcatg tccaggcagg caggacagag caccgagcca gaccaggaat 1860 cagcgggagt gaggcatctg cccacattca ccgtgtgctc tgcagaaagc tccctcaggc 1920 ctcagtctgc acccaggctg ccccggagtg agaccccatc cctgccctcc tgctgccgcc 1980 agagtagctg acagggtggt tccatgtggc ccagtgacat gagggtcatg tggcattacc 2040 agtaacaagc tggcagcaaa gcaaaggggg gatggagtca gctgaaaccc actgggatgg 2100 tgccagcgag gggccttgaa agttgaggag gtttcaggta agcagaaaac aggggtaatg 2160 gcagccagga gccgaaacat gagcaaggct gtccccaaga gcaaggccaa gaagagttcc 2220 ttctgctggg acgagggatc caggagcttg aggcattggg agcaggcagc agagggcagg 2280 tgggcacagt gggcgtgcct ttacagggct cccttctccc gccaggcatg ggctgcaacg 2340 agtgtacgca cccctcctgc cagcactcgc tgagcatgct gggcatcggc cagtgcgtgg 2400 aatgtgagag cggggtgctg gtgctggacc ccacctcggg ccccaagtgg aaggtggcct 2460 gcaacaagtg caacgtggta gcgcactgct tcgagaacgc ccaccgcgtg cgggtgtccg 2520 ccgacacctg cagtgtctgt gaggccgcct tgcttgatgt ggacttcaac aaggccaagt 2580 ccccactccc gggcgatgag acgcagcaca tgggctgcgt cttttgtgac cccgtcttcc 2640 aggagctggt ggagctgaag catgcggcct cctgccaccc catgcaccgc ggtggaccag 2700 ggagaaggca gggtcgaggg cggggccggg ccaggaggcc ccctgggaag cccaacccca 2760 gacggcccaa ggacaagatg tcagccctgg ccgcctactt tgtatgatga ccctgtcctc 2820 cctcacccag gctgcagtgc catgcagaca cctcatggca cttcaaacta ttaaaatgca 2880 ttttatctt 2889 <210> 299 <211> 2100 <212> DNA <213> Homo sapiens <400> 299 gagtctgcct ctggcctgcc cctcaccaga ggggtgtctc tctgtcagca aggccagtac 60 ctggggaccc aggtccccac gtgggaccag ctcccagatc tgggcttcag gcctccgtag 120 gccaggtcag tgacacctcc tggctgggtt gaaagagcag gtgcattaac accacacatg 180 gccaggaaca cgtgcctctg acgcacaggg ctgctgccct gccgtgctgc caggacagta 240 gaaaccaccg cctataggga ccctttcaca ctcagaccct tgaccacgtg ttgcggagcc 300 ttttgctggg gactgggagg gagatgactc ctgcactctg cttgcccgca ggcatggatg 360 agttgatgga ggtgtctttc tcgcccctgg cggccacagg caagcccctc tcacgctgtg 420 ggaagtgcca ccgcttcatg aagtacatcc aggccaagcc aagccgcctg cactgctccc 480 actgcgatga gacctacacg ctcccccaga acggcaccat caagctctac aaggagctcc 540 gctgccctct ggatgacttc gagctggtcc tgtggtcatc aggctctcgg ggcaagagct 600 acccgctgtg cccctactgc tacaaccacc cacccttccg agacatgaag aaaggtgagt 660 gcagccactc cctcctgtcc acaggtagct gcagtctctt ttcagtgcca acccctgcct 720 tgcaccaggc tggactctga ggggacccct caccctggcc tttcctgcac tcattggcac 780 tgagacgaga gaccctggat gtagctgggg cactgcttag gcctcagcca gtggtgccac 840 cctctctctg tgtcagaatc gagcaggcaa ccctagtcca ccctcaggac ctgggcacag 900 gtgtgcagtg ctccctctgg agctgagtga gcaagaggat gcagcagtcg ggggacccac 960 ccggtgagcg ggcaccccca gtcagcgtcc accaccgtcc tccatcctca tcctcgtcct 1020 cattactgga ggagggagcg catgtccagg caggcaggac agagcaccga gccagaccag 1080 gaatcagcgg gagtgaggca tctgcccaca ttcaccgtgt gctctgcaga aagctccctc 1140 aggcctcagt ctgcacccag gctgccccgg gagtgagacc ccatccctgc cctcctgctg 1200 ccgccagagt agctgacagg gtggttccat gtggcccagt gacatgaggg tcatgtggca 1260 ttaccagtaa caagccggca gcaaagcaaa ggggggatgg agtcagctga aacccactgg 1320 gatggtgcca gcgaggggcc ttgaaagttg aggaggtttc aggtaagcag aaaacagggg 1380 taatggcagc caggagccga aacatgagca aggctgtccc caagagcaag gccaagaaga 1440 gttccttctg ctgggacgag ggatccagga gcttgaggca ttgggagcag gcagcagagg 1500 gcaggtgggc acagtgggcg tgcctttaca gggctccctt ctcccgccag gcatgggctg 1560 caacgagtgt acgcacccct cctgccagca ctcgctgagc atgctgggca tcggccagtg 1620 cgtggaatgt gagagcgggg tgctggtgct ggaccccacc tcgggcccca agtggaaggt 1680 ggcctgcaac aagtgcaacg tggtagcgca ctgcttcgag aacgcccacc gcgtgcgggt 1740 gtccgccgac acctgcagtg tctgtgaggc cgccttgctt gatgtggact tcaacaaggc 1800 caagtcccca ctcccgggcg atgagacgca gcacatgggc tgcgtctttt gtgaccccgt 1860 cttccaggag ctggtggagc tgaagcatgc ggcctcctgc caccccatgc accgcggtgg 1920 accagggaga aggcagggtc gagggcgggg ccgggccagg aggccccctg ggaagcccaa 1980 ccccagacgg cccaaggaca agatgtcagc cctggccgcc tactttgtat gatgaccctg 2040 tcctccctca cccaggctgc agtgccatgc agacacctca tggcacttca aactattaaa 2100 <210> 300 <211> 765 <212> DNA <213> Homo sapiens <400> 300 atgactgggg gcagcagcct gagcagtgcc gaccacagcg cacacgcaga accaggagcc 60 atggagcccc accgtgtgcc ccaccgtgca gcctcctcgg ccaccttcaa acagctgcat 120 cctcaacagg ttatgaggcc ccaaggagaa caggaaaaga tgatctctag gtgccaagat 180 gaaattgcac actggcaaaa ggaaggcttg tggataccag caaaatcact cttctcctcg 240 gggacaactg gttttgccag tgctctgcaa agcaagcagt ggggcatggg ctgcaacgag 300 tgtacgcacc cctcctgcca gcactcgctg agcatgctgg gcatcggcca gtgcgtggaa 360 tgtgagagcg gggtgctggt gctggacccc acctcgggcc ccaagtggaa ggtggcctgc 420 aacaagtgca acgtggtagc gcactgcttc gagaacgccc accgcgtgcg ggtgtccgcc 480 gacacctgca gtgtctgtga ggccgccttg cttgatgtgg acttcaacaa ggccaagtcc 540 ccactcccgg gcgatgaggc gcagcacatg ggctgcgtct tttgtgaccc cgtcttccag 600 gagctggtgg agctgaagca tgcggcctcc tgccacccca tgcaccgcgg tggaccaggg 660 agaaggcagg gtcgagggcg gggccgggcc aggaggcccc ctgggaagcc caaccccaga 720 cggcccaagg acaagatgtc agccctggcc gcctactttg tatga 765 <210> 301 <211> 4072 <212> DNA <213> Homo sapiens <400> 301 ctggattcgg tgctgaggcg gcggctgcgg cacgggaaag gctcagtgac tgaagctcca 60 aaggccagca ggctggtggg gacgtgaccg aagcgaggct ctggttccct ttcggtgggc 120 gccatttgag cctcatctct ggcttcccca ggatgcgccg gcagccgggg agcggctccg 180 ggcgcgaggt ctgaggatga tctttcctgt cgcccgctac gcgctccggt ggctgcgacg 240 gcccgaagac cgtgcctttt cccgcgccgc catggagatg gccctccgag gcgtgcggaa 300 agtcctctgt gtggccgaaa aaaacgacgc ggccaagggg atcgccgacc tgctgtcaaa 360 cggtcgcatg aggcggagag aaggactttc aaaattcaac aagatctatg aatttgatta 420 tcatctgtat ggccagaatg ttaccatggt aatgacttca gtttctggac atttactggc 480 tcatgatttc cagatgcagt ttcgaaaatg gcagagctgc aaccctcttg tcctctttga 540 agcagaaatt gaaaagtact gcccagagaa ttttgtagac atcaagaaaa ctttggaacg 600 agagactcgc cagtgccagg ctctggtgat ctggactgac tgtgatagag aaggcgaaaa 660 catcgggttt gagattatcc acgtgtgtaa ggctgtaaag cccaatctgc aggtgttgcg 720 agcccgattc tctgagatca caccccatgc cgtcaggaca gcttgtgaaa acctgaccga 780 gcctgatcag agggtgagcg atgctgtgga tgtgaggcag gagctggacc tgaggattgg 840 agctgccttt actaggttcc agaccctgcg gcttcagagg atttttcctg aggtgctggc 900 agagcagctc atcagttacg gcagctgcca gttccccaca ctgggctttg tggtggagcg 960 gttcaaagcc attcaggctt ttgtaccaga aatcttccac agaattaaag taactcatga 1020 ccacaaagat ggtatcgtag aattcaactg gaaaaggcat cgactcttta accacacggc 1080 ttgcctagtt ctctatcagt tgtgtgtgga ggatcccatg gcaactgtgg tagaggtcag 1140 atctaagccc aagagcaagt ggcggcctca agccttggac actgtggagc ttgagaagct 1200 ggcttctcga aagttgagaa taaatgctaa agaaaccatg aggattgctg agaagctcta 1260 cactcaaggg tacatcagct atccccgaac agaaacaaac atttttccca gagacttaaa 1320 cctgacggtg ttggtggaac agcagacccc cgatccacgc tggggggcct ttgcccagag 1380 cattctagag cggggtggtc ccaccccacg caatgggaac aagtctgacc aagctcaccc 1440 tcccattcac cccaccaaat acaccaacaa cttacaggga gatgaacagc gactgtacga 1500 gtttattgtt cgccatttcc tggcttgctg ctcccaggat gctcaggggc aggagaccac 1560 agtggagatc gacatcgctc aggaacgctt tgtggcccat ggcctcatga ttctggcccg 1620 aaactatctg gatgtgtatc catatgatca ctggagtgac aagatcctcc ctgtctatga 1680 gcaaggatcc cactttcagc ccagcaccgt ggagatggtg gacggggaga ccagcccacc 1740 caagctgctc accgaggccg acctcattgc cctcatggag aagcatggca ttggtacgga 1800 tgccactcat gcggagcaca tcgagaccat caaagcccgg atgtacgtgg gcctcacccc 1860 agacaagcgg ttcctccctg ggcacctggg catgggactt gtggaaggtt atgattccat 1920 gggctatgaa atgtctaagc ctgacctccg ggctgaactg gaagctgatc tgaagctgat 1980 ctgtgatggc aaaaaggaca aatttgtggt tctaaggcag caagtgcaga aatacaagca 2040 ggttttcatt gaagcggtgg ctaaagcaaa gaaattggac gaggccttgg cccagtactt 2100 tgggaatggg acagagttgg cccagcaaga agatatctac ccagccatgc cagagcccat 2160 caggaagtgc ccacagtgca acaaggacat ggtccttaag accaagaaga atggcgggtt 2220 ctacctcagc tgcatgggtt tcccagagtg tcgctcagct gtgtggcttc ctgactcggt 2280 gctggaggcc agcagggaca gcagtgtgtg tccagtttgt cagccacacc ctgtgtacag 2340 gttaaagtta aagtttaagc gcggtagcct tcccccgacc atgcctctgg agtttgtttg 2400 ctgcatcggc ggatgcgacg acaccctgag ggagatcctg gacctgagat tttcaggggg 2460 cccccccagg gctagccagc cctctggccg cctgcaggct aaccagtccc tgaacaggat 2520 ggacaacagc cagcaccccc agcctgctga cagcagacag actgggtcct caaaggctct 2580 ggcccagacc ctcccaccac ccacggctgc tggtgaaagc aattctgtga cctgcaactg 2640 tggccaggag gctgtgctgc tcactgtccg taaggagggc cccaaccggg gccggcagtt 2700 ctttaagtgc aacggaggta gctgcaactt cttcctgtgg gcagacagcc ccaatccggg 2760 agcaggaggg cctcctgcct tggcatatag acccctgggc gcctccctgg gatgcccacc 2820 aggcccaggg atccacctag gtgggtttgg caaccctggt gatggcagtg gtagtggcac 2880 atcctgcctt tgcagccagc cctccgtcac acggactgtg cagaaggatg gacccaacaa 2940 ggggcgccag ttccacacat gtgccaagcc gagagagcag cagtgtggct ttttccagtg 3000 ggtcgatgag aacaccgctc cagggacttc tggagccccg tcctggacag gagacagagg 3060 aagaaccctg gagtcggaag ccagaagcaa aaggccccgg gccagttcct cagacatggg 3120 gtccacagca aagaaacccc ggaaatgcag cctttgccac cagcctggac acacccgtcc 3180 cttttgtcct cagaacagat gagctcaggg tagggtagag aacgccactt tctcagacct 3240 gtcccctttg tgtttagaaa tgagttaacc aggaccaagt ggccatttag tgtcctggaa 3300 acttagagga cagtgttggc ctttggagtc gggccttctt gtgttaaggg gcacaaggtc 3360 cagatcactc tggagcaggc cagctctgct ggacagtgac cctcttccca ggcctcagga 3420 gtgaccatag ccactgctga aaagtcacgc agctgctccc tcggaccccc caaggatggt 3480 tgctgttagc agaggattgg tgcagtccca gctgaagccc actgtgtgcc aaaggaagaa 3540 gctcccaggg ctgcttcctt cacctgcaga aagccccaag tgagccacca gcactcatgg 3600 ggcagtccct gtccaggctg cccagggctt ctcatagacg tcctgagaag gacggtgtaa 3660 tgcaaggaaa tggctgtggt aacactgatc cttcagaaga agcttcattc cctcttaatc 3720 tagttaagcc aggacatcca gaattcattg ctttaataaa gaacccaggc cgggtgcagt 3780 ggctcatgcc tgtaatccca gcactttggg aggctgtggg gggcggattg cctgagctca 3840 ggagttcgag accagccagg gcaacatggt gaaaccctgt ctctactaaa atacaaaaaa 3900 ttagccaggt gtggcggtgt gcgcctgtag acccggctac tcaggaggct gaggcaggag 3960 aattgcttga acccgggagg cggaggttgc agttagctga gattgcgcca ctggacgaca 4020 gagcgagact cagtctcaaa aaaaaattta aaaatttaaa aaaaaaaaaa aa 4072 <210> 302 <211> 3807 <212> DNA <213> Homo sapiens <400> 302 ggagaaggcg ggcggaagtt ccacgccaag atactggatt cggtgctgag gcggcggctg 60 cggcacggga aaggctcagt gactgaagct ccaaaggcca gcaggctggt ggggacgtga 120 ccgaagcgag gctctggttc cctttcggtg ggcgccattt gagcctcatc tctggcttcc 180 ccaggatgcg ccggcagccg gggagcggct ccgggcgcga ggtctgagga tgatctttcc 240 tgtcgcccgc tacgcgctcc ggtggctgcg acggcccgaa gaccgtgcct tttcccgcgc 300 cgccatggag atggccctcc gaggcgtgcg gaaagtcctc tgtgtggccg aaaaaaacga 360 cgcggccaag gggatcgccg acctgctgtc aaacggtcgc atgaggcgga gagaaggact 420 ttcaaaattc aacaagatct atgaatttga ttatcatctg tatggccaga atgttaccat 480 ggtaatgact tcagtttctg gacatttact ggctcatgat ttccagatgc agtttcgaaa 540 atggcagagc tgcaaccctc ttgtcctctt tgaagcagaa attgaaaagt actgcccaga 600 gaattttgta gacatcaaga aaactttgga acgagagact cgccagtgcc aggctctggt 660 gatctggact gactgtgata gagaaggcga aaacatcggg tttgagatta tccacgtgtg 720 taaggctgta aagcccaatc tgcaggtgtt gcgagcccga ttctctgaga tcacacccca 780 tgccgtcagg acagcttgtg aaaacctgac cgagcctgat cagagggtga gcgatgctgt 840 ggatgtgagg caggagctgg acctgaggat tggagctgcc tttactaggt tccagaccct 900 gcggcttcag aggatttttc ctgaggtgct ggcagagcag ctcatcagtt acggcagctg 960 ccagttcccc acactgggct ttgtggtgga gcggttcaaa gccattcagg cttttgtacc 1020 agaaatcttc cacagaatta aagtaactca tgaccacaaa gatggtatcg tagaattcaa 1080 ctggaaaagg catcgactct ttaaccacac ggcttgccta gttctctatc agttgtgtgt 1140 ggaggatccc atggcaactg tggtagaggt cagatctaag cccaagagca agtggcggcc 1200 tcaagccttg gacactgtgg agcttgagaa gctggcttct cgaaagttga gaataaatgc 1260 taaagaaacc atgaggattg ctgagaagct ctacactcaa gggtacatca gctatccccg 1320 aacagaaaca aacatttttc ccagagactt aaacctgacg gtgttggtgg aacagcagac 1380 ccccgatcca cgctgggggg cctttgccca gagcattcta gagcggggtg gtcccacccc 1440 acgcaatggg aacaagtctg accaagctca ccctcccatt caccccacca aatacaccaa 1500 caacttacag ggagatgaac agcgactgta cgagtttatt gttcgccatt tcctggcttg 1560 ctgctcccag gatgctcagg ggcaggagac cacagtggag atcgacatcg ctcaggaacg 1620 ctttgtggcc catggcctca tgattctggc ccgaaactat ctggatgtgt atccatatga 1680 tcactggagt gacaagatcc tccctgtcta tgagcaagga tcccactttc agcccagcac 1740 cgtggagatg gtggacgggg agaccagccc acccaagctg ctcaccgagg ccgacctcat 1800 tgccctcatg gagaagcatg gcattggtac ggatgccact catgcggagc acatcgagac 1860 catcaaagcc cggatgtacg tgggcctcac cccagacaag cggttcctcc ctgggcacct 1920 gggcatggga cttgtggaag gttatgattc catgggctat gaaatgtcta agcctgacct 1980 ccgggctgaa ctggaagctg atctgaagct gatctgtgat ggcaaaaagg acaaatttgt 2040 ggttctaagg cagcaagtgc agaaatacaa gcaggttttc attgaagcgg tggctaaagc 2100 aaagaaattg gacgaggcct tggcccagta ctttgggaat gggacagagt tggcccagca 2160 agaagatatc tacccagcca tgccagagcc catcaggaag tgcccacagt gcaacaagga 2220 catggtcctt aagaccaaga agaatggcgg gttctacctc agctgcatgg gtttcccaga 2280 gtgtcgctca gctgtgtggc ttcctgactc ggtgctggag gccagcaggg acagcagtgt 2340 gtgtccagtt tgtcagccac accctgtgta caggttaaag ttaaagttta agcgcggtag 2400 ccttcccccg accatgcctc tggagtttgt ttgctgcatc ggcggatgcg acgacaccct 2460 gagggagatc ctggacctga gattttcagg gggccccccc agggctagcc agccctctgg 2520 ccgcctgcag gctaaccagt ccctgaacag gatggacaac agccagcacc cccagcctgc 2580 tgacagcaga cagactgggt cctcaaaggc tctggcccag accctcccac cacccacggc 2640 tgctggtgaa agcaattctg tgacctgcaa ctgtggccag gaggctgtgc tgctcactgt 2700 ccgtaaggag ggccccaacc ggggccggca gttctttaag tgcaacggag gtagctgcaa 2760 cttcttcctg tgggcagaca gccccaatcc gggagcagga gggcctcctg ccttggcata 2820 tagacccctg ggcgcctccc tgggatgccc accaggccca gggatccacc taggtgggtt 2880 tggcaaccct ggtgatggca gtggtagtgg cacatcctgc ctttgcagcc agccctccgt 2940 cacacggact gtgcagaagg atggacccaa caaggggcgc cagttccaca catgtgccaa 3000 gccgagagag cagcagtgtg gctttttcca gtgggtcgat gagaacaccg ctccagggac 3060 ttctggagcc ccgtcctgga caggagacag aggaagaacc ctggagtcgg aagccagaag 3120 caaaaggccc cgggccagtt cctcagacat ggggtccaca gcaaagaaac cccggaaatg 3180 cagcctttgc caccagcctg gacacacccg tcccttttgt cctcagaaca gatgagctca 3240 gggtagggta gagaacgcca ctttctcaga cctgtcccct ttgtgtttag aaatgagtta 3300 accaggacca agtggccatt tagtgtcctg gaaacttaga ggacagtgtt ggcctttgga 3360 gtcgggcctt cttgtgttaa ggggcacaag gtccagatca ctctggagca ggccagctct 3420 gctggacagt gaccctcttc ccaggcctca ggagtgacca tagccactgc tgaaaagtca 3480 cgcagctgct ccctcggacc ccccaaggat ggttgctgtt agcagaggat tggtgcagtc 3540 ccagctgaag cccactgtgt gccaaaggaa gaagctccca gggctgcttc cttcacctgc 3600 agaaagcccc aagtgagcca ccagcactca tggggcagtc cctgtccagg ctgcccaggg 3660 cttctcatag acgtcctgag aaggacggtg taatgcaagg aaatggctgt ggtaacactg 3720 atccttcaga agaagcttca ttccctctta atctagttaa gccaggacat ccagaattca 3780 ttgctttaat aaagaaccca ggccggg 3807 <210> 303 <211> 3755 <212> DNA <213> Homo sapiens <400> 303 ggcggctgcg gcacgggaaa ggctcagtga ctgaagctcc aaaggccagc aggctggtgg 60 ggacgtgacc gaagcgaggc tctggttccc tttcggtggg cgccatttga gcctcatctc 120 tggcttcccc aggatgcgcc ggcagccggg gagcggctcc gggcgcgagg tctgaggatg 180 atctttcctg tcgcccgcta cgcgctccgg tggctgcgac ggcccgaaga ccgtgccttt 240 tcccgcgccg ccatggagat ggccctccga ggcgtgcgga aagtcctctg tgtggccgaa 300 aaaaacgacg cggccaaggg gatcgccgac ctgctgtcaa acggtcgcat gaggcggaga 360 gaaggacttt caaaattcaa caagatctat gaatttgatt atcatctgta tggccagaat 420 gttaccatgg taatgacttc agtttctgga catttactgg ctcatgattt ccagatgcag 480 tttcgaaaat ggcagagctg caaccctctt gtcctctttg aagcagaaat tgaaaagtac 540 tgcccagaga attttgtaga catcaagaaa actttggaac gagagactcg ccagtgccag 600 gctctggtga tctggactga ctgtgataga gaaggcgaaa acatcgggtt tgagattatc 660 cacgtgtgta aggctgtaaa gcccaatctg caggtgttgc gagcccgatt ctctgagatc 720 acaccccatg ccgtcaggac agcttgtgaa aacctgaccg agcctgatca gagggtgagc 780 gatgctgtgg atgtgaggca ggagctggac ctgaggattg gagctgcctt tactaggttc 840 cagaccctgc ggcttcagag gatttttcct gaggtgctgg cagagcagct catcagttac 900 ggcagctgcc agttccccac actgggcttt gtggtggagc ggttcaaagc cattcaggct 960 tttgtaccag aaatcttcca cagaattaaa gtaactcatg accacaaaga tggtatcgta 1020 gaattcaact ggaaaaggca tcgactcttt aaccacacgg cttgcctagt tctctatcag 1080 ttgtgtgtgg aggatcccat ggcaactgtg gtagaggtca gatctaagcc caagagcaag 1140 tggcggcctc aagccttgga cactgtggag cttgagaagc tggcttctcg aaagttgaga 1200 ataaatgcta aagaaaccat gaggattgct gagaagctct acactcaagg gtacatcagc 1260 tatccccgaa cagaaacaaa catttttccc agagacttaa acctgacggt gttggtggaa 1320 cagcagaccc ccgatccacg ctggggggcc tttgcccaga gcattctaga gcggggtggt 1380 cccaccccac gcaatgggaa caagtctgac caagctcacc ctcccattca ccccaccaaa 1440 tacaccaaca acttacaggg agatgaacag cgactgtacg agtttattgt tcgccatttc 1500 ctggcttgct gctcccagga tgctcagggg caggagacca cagtggagat cgacatcgct 1560 caggaacgct ttgtggccca tggcctcatg attctggccc gaaactatct ggatgtgtat 1620 ccatatgatc actggagtga caagatcctc cctgtctatg agcaaggatc ccactttcag 1680 cccagcaccg tggagatggt ggacggggag accagcccac ccaagctgct caccgaggcc 1740 gacctcattg ccctcatgga gaagcatggc attggtacgg atgccactca tgcggagcac 1800 atcgagacca tcaaagcccg gatgtacgtg ggcctcaccc cagacaagcg gttcctccct 1860 gggcacctgg gcatgggact tgtggaaggt tatgattcca tgggctatga aatgtctaag 1920 cctgacctcc gggctgaact ggaagctgat ctgaagctga tctgtgatgg caaaaaggac 1980 aaatttgtgg ttctaaggca gcaagtgcag aaatacaagc aggttttcat tgaagcggtg 2040 gctaaagcaa agaaattgga cgaggccttg gcccagtact ttgggaatgg gacagagttg 2100 gcccagcaag aagatatcta cccagccatg ccagagccca tcaggaagtg cccacagtgc 2160 aacaaggaca tggtccttaa gaccaagaag aatggcgggt tctacctcag ctgcatgggt 2220 ttcccagagt gtcgctcagc tgtgtggctt cctgactcgg tgctggaggc cagcagggac 2280 agcagtgtgt gtccagtttg tcagccacac cctgtgtaca ggttaaagtt aaagtttaag 2340 cgcggtagcc ttcccccgac catgcctctg gagtttgttt gctgcatcgg cggatgcgac 2400 gacaccctga gggagatcct ggacctgaga ttttcagggg gcccccccag ggctagccag 2460 ccctctggcc gcctgcaggc taaccagtcc ctgaacagga tggacaacag ccagcacccc 2520 cagcctgctg acagcagaca gactgggtcc tcaaaggctc tggcccagac cctcccacca 2580 cccacggctg ctggtgaaag caattctgtg acctgcaact gtggccagga ggctgtgctg 2640 ctcactgtcc gtaaggaggg ccccaaccgg ggccggcagt tctttaagtg caacggaggt 2700 agctgcaact tcttcctgtg ggcagacagc cccaatccgg gagcaggagg gcctcctgcc 2760 ttggcatata gacccctggg cgcctccctg ggatgcccac caggcccagg gatccaccta 2820 ggtgggtttg gcaaccctgg tgatggcagt ggtagtggca catcctgcct ttgcagccag 2880 ccctccgtca cacggactgt gcagaaggat ggacccaaca aggggcgcca gttccacaca 2940 tgtgccaagc cgagagagca gcagtgtggc tttttccagt gggtcgatga gaacaccgct 3000 ccagggactt ctggagcccc gtcctggaca ggagacagag gaagaaccct ggagtcggaa 3060 gccagaagca aaaggccccg ggccagttcc tcagacatgg ggtccacagc aaagaaaccc 3120 cggaaatgca gcctttgcca ccagcctgga cacacccgtc ccttttgtcc tcagaacaga 3180 tgagctcagg gtagggtaga gaacgccact ttctcagacc tgtccccttt gtgtttagaa 3240 atgagttaac caggaccaag tggccattta gtgtcctgga aacttagagg acagtgttgg 3300 cctttggagt cgggccttct tgtgttaagg ggcacaaggt ccagatcact ctggagcagg 3360 ccagctctgc tggacagtga ccctcttccc aggcctcagg agtgaccata gccactgctg 3420 aaaagtcacg cagctgctcc ctcggacccc ccaaggatgg ttgctgttag cagaggattg 3480 gtgcagtccc agctgaagcc cactgtgtgc caaaggaaga agctcccagg gctgcttcct 3540 tcacctgcag aaagccccaa gtgagccacc agcactcatg gggcagtccc tgtccaggct 3600 gcccagggct tctcatagac gtcctgagaa ggacggtgta atgcaaggaa atggctgtgg 3660 taacactgat ccttcagaag aagcttcatt ccctcttaat ctagttaagc caggacatcc 3720 agaattcatt gctttaataa agaacccagg ccggg 3755 <210> 304 <211> 728 <212> DNA <213> Homo sapiens <400> 304 cgacttcgga gaggcagcgc ggttcctctg ggtgcttccg cctccccttc tcctgcttct 60 ccagcctctt cggcctcctc gcccgccgcg ggaacccgag accccagtgt atgccccacc 120 cctgaccccg ctcgcgacat gtccaccccg gctcggcggc gcctcatgcg ggacttcaag 180 aggttgcagg aggatcctcc agccggagtc agcggggctc cgtccgagaa caacataatg 240 gtgtggaacg cggtcatttt cgggcctgaa gggaccccgt ttgaggatgg aacatttaaa 300 cttacaatag aattcactga agaatatcca aataaaccac ctacagttag atttgtctct 360 aagatgttcc atccaaatgt ctatgcagat ggtagtatat gtctggacat acttcagaac 420 cgttggagtc caacctatga tgtgtcttcc attctaacat ccatacagtc tctgttggat 480 gaacccaatc ccaatagtcc agcaaacagc caggctgctc agctgtacca ggagaacaaa 540 cgggaatatg aaaagcgtgt ttctgcaata gtagaacaaa gctggcgtga ttgttgaccc 600 cgggtacagt ttaaagaagc tggccataag aaaaatatat attgatgtgt ttgtcacctc 660 cctactcctg tcattacatt tactttatta aaagcaaaat aactgttaaa aaaaaaaaaa 720 aaaaaaaa 728 <210> 305 <211> 1799 <212> DNA <213> Homo sapiens <400> 305 acactggggt ggtgcttagc cggcgccaga ccgaccctcg acttcggaga ggcagcgcgg 60 ttcctctggg tgcttccgcc tccccttctc ctgcttctcc agcctcttcg gcctcctcgc 120 ccgccgcggg aacccgagac cccagtgtat gccccacccc tgaccccgct cgcgacatgt 180 ccaccccggc tcggcggcgc ctcatgcggg acttcaagag gttgcaggag gatcctccag 240 ccggagtcag cggggctccg tccgagaaca acataatggt gtggaacgcg gtcattttcg 300 ggcctgaagg gaccccgttt gaggatggaa catttaaact tacaatagaa ttcactgaag 360 aatatccaaa taaaccacct acagttagat ttgtctctaa gatgttccat ccaaatgtct 420 atgcagatgg tagtatatgt ctggacatac ttcagaaccg ttggagtcca acctatgatg 480 tgtcttccat tctaacatcc atacagtctc tgttggatga acccaatccc aatagtccag 540 caaacagcca ggctgctcag ctgtaccagg agaacaaacg ggaatatgaa aagcgtgttt 600 ctgcaatagt agaacaaagc tggcgtgatt gttgaccccg ggtacagttt aaagaagctg 660 gccataagaa aaatatatat tgatgtgttt gtcacctccc tactcctgtc attacattta 720 ctttattaaa agcaaaataa ctgttgtgct gtttccatct tccttgccaa gttttcctac 780 cccttctacc ctctccttaa acatcagaaa acaccctcta tgaaatcaaa tgtactgtac 840 ctgggttact tgcaaaaatt actaatgctt cagtttttct gttgtatttc atttccagtt 900 ttcaggcagt tatttttatt attgtacttt aagcttttaa gatgaattgt tatacaagag 960 gtgcttatgc ttagcttgat gaccaggatg ttatttttaa caaaatgatt gctgaagtgt 1020 ttcatcctgg ctggtccttc acttgtgttg gatttagaag tgaatgtgtt tggaatatgg 1080 cctacagaga atagaaacaa atccatgtaa acaattttga aggaggcatg ggagctaaaa 1140 atcctgtgat actaagatct cagtcatatg aattacaacg tagtatttac tggcaagaag 1200 gagaaagttg aaggactcag ctaaaggagt acagcaattg tagtaactga cacatcctct 1260 ctttgcaagc tgctgactgg gcacactcat gccaagtttc agaattattg gtcttctggg 1320 tttttgcttt ttaaaagagg tgtgggagca gaggaatgga aacaatcgtg agtttttgag 1380 ctagggaaag ttggagctcc tttaatcttt ttaaaggatc agtgctgccc taagtgaata 1440 aactcaattg tccatcttta ttttagagtt ttaatgaatt caaggaaggg agcatagcat 1500 atctgtggca aactattttc cactcaaatc ctgagttatt gctgcatgct ttaatttctt 1560 ccctttcagc atctgagaac cttaaagcca atgtctgcga tctttttttg gatatttata 1620 cttttagata tatagtacct ttaagtagca gtatgggaca aggcttgtaa atgttttgtc 1680 taatgttcta ttgtcacctt ttatgcattt atcacttcca aatctaactt tgcacaagta 1740 acccatgtaa aaaaaaatgt acatttttca aaagttgtaa ataaaaataa ccttaaaaa 1799 <210> 306 <211> 1743 <212> DNA <213> Homo sapiens <400> 306 gcggttcctc tgggtgcttc cgcctcccct tctcctgctt ctccagcctc ttcggcctcc 60 tcgcccgccg cgggaacccg agaccccagt gtatgcccca cccctgaccc cgctcgcgac 120 atgtccaccc cggctcggcg gcgcctcatg cgggacttca agaggttgca ggaggatcct 180 ccagccggag tcagcggggc tccgtccgag aacaacataa tggtgtggaa cgcggtcatt 240 ttcgggcctg aagggacccc gtttggggat ggaacattta aacttacaat agaattcact 300 gaagaatatc caaataaacc acctacagtt agatttgtct ctaagatgtt ccatccaaat 360 gtctatgcag atggtagtat atgtctggac atacttcaga accgttggag tccaacctat 420 gatgtgtctt ccattctaac atccatacag tctctgttgg atgaacccaa tcccaatagt 480 ccagcaaaca gccaggctgc tcagctgtac caggagaaca aacgggaata tgaaaagcgt 540 gtttctgcaa tagtagaaca aagctggcgt gattgttgac cccgggtaca gtttaaagaa 600 gctggccata agaaaaatat atattgatgt gtttgtcacc tccctactcc tgtcattaca 660 tttactttat taaaagcaaa ataactgttg tgctgtttcc atcttccttg ccaagttttc 720 ctaccccttc taccctctcc ttaaacatca gaaaacaccc tctatgaaat caaatgtact 780 gtacctgggt tacttgcaaa aattactaat gcttcagttt ttctgttgta tttcatttcc 840 agttttcagg cagttatttt tattattgta ctttaagctt ttaagatgaa ttgttataca 900 agaggtgctt atgcttagct tgatgaccag gatgttattt ttaacaaaat gattgctgaa 960 gtgtttcatc ctggctggtc cttcacttgt gttggattta gaagtgaatg tgtttggaat 1020 atggcctaca gagaatagaa acaaatccat gtaaacaatt ttgaaggagg catgggagct 1080 aaaaatcctg tgatactaag atctcagtca tatgaattac aacgtagtat ttactggcaa 1140 gaaggagaaa gttgaaggac tcagctaaag gagtacagca attgtagtaa ctgacacatc 1200 ctctctttgc aagctgctga ctgggcacac tcatgccaag tttcagaatt attggtcttc 1260 tgggtttttg ctttttaaaa gaggtgtggg agcagaggaa tggaaacaat cgtgagtttt 1320 tgagctaggg aaagttggag ctcctttaat ctttttaaag gatcagtgct gccctaagtg 1380 aataaactca attgtccatc tttattttag agttttaatg aattcaagga agggagcata 1440 gcatatctgt ggcaaactat tttccactca aatcctgagt tattgctgca tgctttaatt 1500 tcttcccttt cagcatctga gaaccttaaa gccaatgtct gcgatctttt tttggatatt 1560 tatactttta gatatatagt acctttaagt agcagtatgg gacaaggctt gtaaatgttt 1620 tgtctaatgt tctattgtca ccttttatgc atttatcact tccaaatcta actttgcaca 1680 agtaacccat gtaaaaaaaa atgtacattt ttcaaaagtt gtaaataaaa ataaccttaa 1740 aaa 1743 <210> 307 <211> 2678 <212> DNA <213> Homo sapiens <400> 307 tagtcttctc tctttcttaa gcagtgataa accttttaat gagaacaaaa aggaaataaa 60 ttgctaactc tgaaggaacc agtaagaaat acactgaagt atggtctgtt gttttagaat 120 aatttgttaa atggaccaga gtaatatagt ggaacatgca tcaccttata ccatatagta 180 actgattctt ctaagtttac ttgaacagat ttcagtcagg aaaaaacatt gctcaattgt 240 gttcttcaat ttattcaaca aacaattgaa aataatattt taaaggacat aatctcttca 300 tatcacatct taacaattct tgaatgagat ccagtttgtc catgccttgt aagtaagttt 360 ataacctact atgctttagg gcctcctgct accttaggtt gacatatatt taagaaaaat 420 aatttcattt caatagtagc ataaacatta gaaaaataaa tttgctggaa acatgaatgc 480 aatctaaacc aaatgtgatt ttaaaattat ttctgccatt aattccctcc atatgtgtga 540 ataattgagt tgattttata gtgaagtacc ttatgagcca tacttaaggg tttctgagag 600 ggactatgaa gtttttcctg gcttaaattc aattaagttt tcattatagg gtcactatga 660 catgaaaagg aaccagtatg aacactttta tacttattcc cttctatttt aaaaataact 720 tgattatgga tttgtattct ggcattggtt tttgaaccat tgtgctttca ttctttctag 780 tctgtctaaa aatcactgga gcgtttaaga tggcagctga ctaacatagg cctttgaggt 840 cttttggtct tctaaaggaa gaaggccaaa ttttgggccc agtttcttaa ggatgttttc 900 aaaatgtaca gtggctaaaa tcttgtaagc agtaattttg tgtttatgat ggctgtctcc 960 aagtttgggg gaaaataatg gcaaaacaaa aaatcacatt tgagtagttc ttagagcaat 1020 tcctagagat gtatttctta cctggccttt cctctctacc ctgtatcttt gcattattta 1080 atacttggaa aaacccacat agcattaaaa acaaagtact actgaacaaa gtgataaata 1140 cattttctta aatctttctt ttctaaccac aggaacattt aaacttacaa tagaattcac 1200 tgaagaatat ccaaataaac cacctacagt tagatttgtc tctaagatgt tccatccaaa 1260 tgtctatgca gatggtagta tatgtctgga catacttcag aaccgttgga gtccaaccta 1320 tgatgtgtct tccattctaa catccataca gtctctgttg gatgaaccca atcccaatag 1380 tccagcaaac agccaggctg ctcagctgta ccaggagaac aaacgggaat atgaaaagcg 1440 tgtttctgca atagtagaac aaagctggcg tgattgttga ccccgggtac agtttaaaga 1500 agctggccat aagaaaaata tatattgatg tgtttgtcac ctccctactc ctgtcattac 1560 atttacttta ttaaaagcaa aataactgtt gtgctgtttc catcttcctt gccaagtttt 1620 cctacccctt ctaccctctc cttaaacatc agaaaacacc ctctatgaaa tcaaatgtac 1680 tgtacctggg ttacttgcaa aaattactaa tgcttcagtt tttctgttgt atttcatttc 1740 cagttttcag gcagttattt ttattattgt actttaagct tttaagatga attgttatac 1800 aagaggtgct tatgcttagc ttgatgacca ggatgttatt tttaacaaaa tgattgctga 1860 agtgtttcat cctggctggt ccttcacttg tgttggattt agaagtgaat gtgtttggaa 1920 tatggcctac agagaataga aacaaatcca tgtaaacaat tttgaaggag gcatgggagc 1980 taaaaatcct gtgatactaa gatctcagtc atatgaatta caacgtagta tttactggca 2040 agaaggagaa agttgaagga ctcagctaaa ggagtacagc aattgtagta actgacacat 2100 cctctctttg caagctgctg actgggcaca ctcatgccaa gtttcagaat tattggtctt 2160 ctgggttttt gctttttaaa agaggtgtgg gagcagagga atggaaacaa tcgtgagttt 2220 ttgagctagg gaaagttgga gctcctttaa tctttttaaa ggatcagtgc tgccctaagt 2280 gaataaactc aattgtccat ctttatttta gagttttaat gaattcaagg aagggagcat 2340 agcatatctg tggcaaacta ttttccactc aaatcctgag ttattgctgc atgctttaat 2400 ttcttccctt tcagcatctg agaaccttaa agccaatgtc tgcgatcttt ttttggatat 2460 ttatactttt agatatatag tacctttaag tagcagtatg ggacaaggct tgtaaatgtt 2520 ttgtctaatg ttctattgtc accttttatg catttatcac ttccaaatct aactttgcac 2580 aagtaaccca tgtaaaaaaa aatgtacatt tttcaaaagt tgtaaataaa aataacctta 2640 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa 2678 <210> 308 <211> 2679 <212> DNA <213> Homo sapiens <400> 308 ttagtcttct ctctttctta agcagtgata aaccttttaa tgagaacaaa aaggaaataa 60 attgctaact ctgaaggaac cagtaagaaa tacactgaag tatggtctgt tgttttagaa 120 taatttgtta aatggaccag agtaatatag tggaacatgc atcaccttat accatatagt 180 aactgattct tctaagttta cttgaacaga tttcagtcag gaaaaaacat tgctcaattg 240 tgttcttcaa tttattcaac aaacaattga aaataatatt ttaaaggaca taatctcttc 300 atatcacatc ttaacaattc ttgaatgaga tccagtttgt ccatgccttg taagtaagtt 360 tataacctac tatgctttag ggcctcctgc taccttaggt tgacatatat ttaagaaaaa 420 taatttcatt tcaatagtag cataaacatt agaaaaataa atttgctgga aacatgaatg 480 caatctaaac caaatgtgat tttaaaatta tttctgccat taattccctc catatgtgtg 540 aataattgag ttgattttat agtgaagtac cttatgagcc atacttaagg gtttctgaga 600 gggactatga agtttttcct ggcttaaatt caattaagtt ttcattatag ggtcactatg 660 acatgaaaag gaaccagtat gaacactttt atacttattc ccttctattt taaaaataac 720 ttgattatgg atttgtattc tggcattggt ttttgaacca ttgtgctttc attctttcta 780 gtctgtctaa aaatcactgg agcgtttaag atggcagctg actaacatag gcctttgagg 840 tcttttggtc ttctaaagga agaaggccaa attttgggcc cagtttctta aggatgtttt 900 caaaatgtac agtggctaaa atcttgtaag cagtaatttt gtgtttatga tggctgtctc 960 caagtttggg ggaaaataat ggcaaaacaa aaaatcgcat ttgagtagtt cttagagcaa 1020 ttcctagaga tgtatttctt acctggcctt tcctctctac cctgtatctt tgcattattt 1080 aatacttgga aaaacccaca tagcattaaa aacaaagtac tactgaacaa agtgataaat 1140 acattttctt aaatctttct tttctaacca caggaacatt taaacttaca atagaattca 1200 ctgaagaata tccaaataaa ccacctacag ttagatttgt ctctaagatg ttccatccaa 1260 atgtctatgc agatggtagt atatgtctgg acatacttca gaaccgttgg agtccaacct 1320 atgatgtgtc ttccattcta acatccgtac agtctctgtt ggatgaaccc aatcccaata 1380 gtccagcaaa cagccaggct gctcagctgt accaggagaa caaacgggaa tatgaaaagc 1440 gtgtttctgc aatagtagaa caaagctggc gtgattgttg accccgggta cagtttaaag 1500 aagctggcca taagaaaaat atatattgat gtgtttgtca cctccctact cctgtcatta 1560 catttacttt attaaaagca aaataactgt tgtgctgttt ccatcttcat tgccaagttt 1620 tcctacccct tctaccctct ccttaaacat cagaaaacac cctctatgaa atcaaatgta 1680 ctgtacctgg gttacttgca aaaattacta atgcttcagt ttttctgttg tatttcattt 1740 ccagttttca ggcagttatt tttattattg tactttaagc ttttaagatg aattgttata 1800 caagaggtgc ttatgcttag cttgatgacc aggatgttat ttttaacaaa atgattgctg 1860 aagtgtttca tcctggctgg tccttcactt gtgttggatt tagaagtgaa tgtgtttgga 1920 atatggccta cagagaatag aaacaaatcc atgtaaacaa ttttgaagga ggcatgggag 1980 ctaaaaatcc tgtgatacta agatctcagt catatgaatt acaacgtagt atttactggc 2040 aagaaggaga aagttgaagg actcagctaa aggagtacag caattgtagt aactgacaca 2100 tcctctcttt gcaagctgct gactgggcac actcatgcca agtttcagaa ttattggtct 2160 tctgggtttt tgctttttaa aagaggtgtg ggagcagagg aatggaaaca atcgtgagtt 2220 tttgagctag ggaaagttgg agctccttta atctttttaa aggatcagtg ctgccctaag 2280 tgaataaact caattgtcca tctttatttt agagttttaa tgaattcaag gaagggagca 2340 tagcatatct gtggcaaact attttccact caaatcctga gttattgctg catgctttaa 2400 tttcttccct ttcagcatct gagaacctta aagccaatgt ctgcgatctt tttttggata 2460 tttatacttt tagatatata gtacctttaa gtagcagtat gggacaaggc ttgtaaatgt 2520 tttgtctaat gttctattgt cacattttat gcatttatca cttccaaatc taactttgca 2580 caagtaaccc atgtaaaaaa aaatgtacat ttttcaaaag ttgtaaataa aaataacctt 2640 aaaaaaaaaa aaaaaaaaaa agaaaaaaaa aaaaaaaaa 2679 <210> 309 <211> 1709 <212> DNA <213> Homo sapiens <400> 309 acactggggt ggtgcttagc cggcgccaga ccgaccctcg acttcggaga ggcagcgcgg 60 ttcctctggg tgcttccgcc tccccttctc ctgcttctcc agcctcttcg gcctcctcgc 120 ccgccgcggg aacccgagac cccagtgtat gccccacccc tgaccccgct cgcgacatgt 180 ccaccccggc tcggcggcgc ctcatgcggg acttcaagag gttgcaggag gatcctccag 240 ccggagtcag cggggctccg tccgagaaca acataatggt gtggaacgcg gtcattttcg 300 ggcctgaagg gaccccgttt gaggatgtct atgcagatgg tagtatatgt ctggacatac 360 ttcagaaccg ttggagtcca acctatgatg tgtcttccat tctaacatcc atacagtctc 420 tgttggatga acccaatccc aatagtccag caaacagcca ggctgctcag ctgtaccagg 480 agaacaaacg ggaatatgaa aagcgtgttt ctgcaatagt agaacaaagc tggcgtgatt 540 gttgaccccg ggtacagttt aaagaagctg gccataagaa aaatatatat tgatgtgttt 600 gtcacctccc tactcctgtc attacattta ctttattaaa agcaaaataa ctgttgtgct 660 gtttccatct tccttgccaa gttttcctac cccttctacc ctctccttaa acatcagaaa 720 acaccctcta tgaaatcaaa tgtactgtac ctgggttact tgcaaaaatt actaatgctt 780 cagtttttct gttgtatttc atttccagtt ttcaggcagt tatttttatt attgtacttt 840 aagcttttaa gatgaattgt tatacaagag gtgcttatgc ttagcttgat gaccaggatg 900 ttatttttaa caaaatgatt gctgaagtgt ttcatcctgg ctggtccttc acttgtgttg 960 gatttagaag tgaatgtgtt tggaatatgg cctacagaga atagaaacaa atccatgtaa 1020 acaattttga aggaggcatg ggagctaaaa atcctgtgat actaagatct cagtcatatg 1080 aattacaacg tagtatttac tggcaagaag gagaaagttg aaggactcag ctaaaggagt 1140 acagcaattg tagtaactga cacatcctct ctttgcaagc tgctgactgg gcacactcat 1200 gccaagtttc agaattattg gtcttctggg tttttgcttt ttaaaagagg tgtgggagca 1260 gaggaatgga aacaatcgtg agtttttgag ctagggaaag ttggagctcc tttaatcttt 1320 ttaaaggatc agtgctgccc taagtgaata aactcaattg tccatcttta ttttagagtt 1380 ttaatgaatt caaggaaggg agcatagcat atctgtggca aactattttc cactcaaatc 1440 ctgagttatt gctgcatgct ttaatttctt ccctttcagc atctgagaac cttaaagcca 1500 atgtctgcga tctttttttg gatatttata cttttagata tatagtacct ttaagtagca 1560 gtatgggaca aggcttgtaa atgttttgtc taatgttcta ttgtcacctt ttatgcattt 1620 atcacttcca aatctaactt tgcacaagta acccatgtaa aaaaaaatgt acatttttca 1680 aaagttgtaa ataaaaataa ccttaaaaa 1709 <210> 310 <211> 1355 <212> DNA <213> Homo sapiens <400> 310 agactgaccg cggggcagct gcggagcatg tcgaccccgg cccggaggag gctcatgcgg 60 gatttcaagc ggttacaaga ggacccacct gtgggtgtca gtggcgcacc atctgaaaac 120 aacatcatgc agtggaatgc agttatattt ggaccagaag ggacaccttt tgaagatggt 180 acttttaaac tagtaataga attttctgaa gaatatccaa ataaaccacc aactgttagg 240 tttttatcca aaatgtttca tccaaatgtg tatgctgatg gtagcatatg tttagatatc 300 cttcagaatc gatggagtcc aacatatgat gtatcttcta tcttaacatc aattcagtct 360 ctgctggatg aaccgaatcc taacagtcca gccaatagcc aggcagcaca gctttatcag 420 gaaaacaaac gagaatatga gaaaagagtt tcggccattg ttgaacaaag ctggaatgat 480 tcataataga caactggtct gttaatcttt ttcatcattg ttgtgtataa tttacctctc 540 attagaaagg ctaacaaatt ttaagtgcca caggttttaa ggattctgca gaaaaaaaag 600 aaaaattcct tcagtttaga acctacaaaa gcttgtgtat cttgattaat gtacttttta 660 ttgcatggtg tgaactaagt tattgctgca taaatttgta atatatcctg tttgtatttt 720 tttccaagtg tataatgttg gtgtggagtt ttcatgacag aatatacaca ttttgtaaat 780 ctgtactttt ttcaaatatt gaatgcctta tttttgaatt ctttagattt ttaaattgga 840 gaaaagcact taaagttttt tatatatgaa tattacatgt aaagctgtta aaatacataa 900 cttcagtgca agagactttg tcacttattt ccttatgtgt gtaggagggg ttaataagtc 960 tctagctctc catctattga tagtttcatt tacaatttca aaagaacatt cttatatttt 1020 atcaaggaag tcttcaaatt tgattctaaa tagcgattat aatctccaac tttattttga 1080 atgtacctct attagtttca attgagtaat tctagacata actggtttga ctctgtccaa 1140 ctctgtattt aggccatttg ttacagtttc ttcatgcatt acttactgtt aaaactgtac 1200 cttttgcgat ttcacagttg gcacttctgc catgagcaga gaactgatgc gacttgtttt 1260 gctgcttggt agcactttaa aaaatttttt gattaatgaa gaaagtaaaa ccataaacat 1320 ttgccgaaaa aaaaaaaaaa aaaaaaaaaa aaaaa 1355 <210> 311 <211> 1006 <212> DNA <213> Homo sapiens <400> 311 acagtgattc ggccgccgcg ccggggggtg ggggggctgc gcgggacttt tttttttttc 60 agactgaccg cggggcagct gcggagcatg tcgaccccgg cccggaggag gctcatgcgg 120 gatttcaagc ggttacaaga ggacccacct gtgggtgtca gtggcgcacc atctgaaaac 180 aacatcatgc agtggaatgc agttatattt ggaccagaag ggacaccttt tgaagatggt 240 acttttaaac tagtaataga attttctgaa gaatatccaa ataaaccacc aactgttagg 300 tttttatcca aaatgtttca tccaaatgtg tatgctgatg gtagcatatg tttagatatc 360 cttcagaatc gatggagtcc aacatatgat gtatcttcta tcttaacatc aattcagtct 420 ctgctggatg aaccgaatcc taacagtcca gccaatagcc aggcagcaca gctttatcag 480 gaaaacaaac gagaatatga gaaaagagtt tcggccattg ttgaacaaag ctggaatgat 540 tcataataga caactggtct gttaatcttt ttcatcattg ttgtgtataa tttacctctc 600 attagaaagg ctaacaaatt ttaagtgcca caggttttaa ggattctgca gaaaaaaaag 660 aaaaaagtcc ttcagtttag aacctacaaa agcttgtgta tcttgattaa tgtacttttt 720 attgcatggt gtgaactaag ttattgctgc ataaatttgt aatatatcct gtttgtattt 780 ttttccaagt gtataatgtt ggtgtggagt tttcatgaca gaatatacac attttgtaaa 840 tctgtacttt tttcaaatat tgaatgcctt atttttgaat tctttagatt tttaaattgg 900 agaaaagcac ttaaagtttt ttatatatga atattacatg taaagctgtt aaaatacata 960 acttcagtgc aagagtaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa 1006 <210> 312 <211> 1001 <212> DNA <213> Homo sapiens <400> 312 acagtgattc ggccgccgcg ccggggggtg ggggggctgc gcgggacttt tttttttttc 60 agactgaccg cggggcagct gcggagcatg tcgaccccgg cccggaggag gctcatgcgg 120 gatttcaagc ggttacaaga ggacccacct gtgggtgtca gtggcgcacc atctgaaaac 180 aacatcatgc agtggaatgc agttatattt ggaccagaag ggacaccttt tgaagatggt 240 acttttaaac tagtaataga attttctgaa gaatatccaa ataaaccacc aactgttagg 300 tttttatcca aaatgtttca tccaaatgtg tatgctgatg gtagcatatg tttagatatc 360 cttcagaatc gatggagtcc aacatatgat gtatcttcta tcttaacatc aattcagtct 420 ctgctggatg aaccgaatcc taacagtcca gccaatagcc aggcagcaca gctttatcag 480 gaaaacaaac gagaatatga gaaaagagtt tcggccattg ttgaacaaag ctggaatgat 540 tcataataga caactggtct gttaatcttt ttcatcattg ttgtgtataa tttacctctc 600 attagaaagg ctaacaaatt ttaagtgcca caggttttaa ggattctgca gaaaaaaaag 660 aaaaaagtcc ttcagtttag aacctacaaa agcttgtgta tcttgattaa tgtacttttt 720 attgcatggt gtgaactaag ttattgctgc ataaatttgt aatatatcct gtttgtattt 780 ttttccaagt gtataatgtt ggtgtggagt tttcatgaca gaatatacac attttgtaaa 840 tctgtacttt tttcaaatat tgaatgcctt atttttgaat tctttagatt tttaaattgg 900 agaaaagcac ttaaagtttt ttatatatga atattacatg taaagctgtt aaaatacata 960 acttcagtgc caaaaaaaaa aaaaaaaaaa aaaaaaaaaa a 1001 <210> 313 <211> 2631 <212> DNA <213> Homo sapiens <400> 313 cgtccctctt tctccacccc gccgagccta aactagtgac ggggagggag acgggatagt 60 gtttctgttt cgtggtcttt gaatccacaa cctctagtct gaacacagag aacacaaatt 120 tgtctattac ttcaggaagc ccagggggaa ccgcgccccg ctgaagggct cggggaaggc 180 gcgctcccgc gtcccgcccc ctcctccccc agcactcaca ctgtggtagc ggcggagggc 240 ggagggatcc ggaggcggcg gagggagacg tcattgcagg gttgtttgtc agtctcggcg 300 gcggcggcgg cggcggcggc ggcggcgatc cacagtgatt cggccgccgc gccggggggt 360 gggggggctg cgcgggactt tttttttttc agactgaccg cggggcagct gcggagcatg 420 tcgaccccgg cccggaggag gctcatgcgg gatttcaagc ggttacaaga ggacccacct 480 gtgggtgtca gtggcgcacc atctgaaaac aacatcatgc agtggaatgc agttatattt 540 ggaccagaag ggacaccttt tgaagatggt acttttaaac tagtaataga attttctgaa 600 gaatatccaa ataaaccacc aactgttagg tttttatcca aaatgtttca tccaaatgtg 660 tatgctgatg gtagcatatg tttagatatc cttcagaatc gatggagtcc aacatatgat 720 gtatcttcta tcttaacatc aattcagtct ctgctggatg aaccgaatcc taacagtcca 780 gccaatagcc aggcagcaca gctttatcag gaaaacaaac gagaatatga gaaaagagtt 840 tcggccattg ttgaacaaag ctggaatgat tcataataga caactggtct gttaatcttt 900 ttcatcattg ttgtgtataa tttacctctc attagaaagg ctaacaaatt ttaagtgcca 960 caggttttaa ggattctgca gaaaaaaaag aaaaaagtcc ttcagtttag aacctacaaa 1020 agcttgtgta tcttgattaa tgtacttttt attgcatggt gtgaactaag ttattgctgc 1080 ataaatttgt aatatatcct gtttgtattt ttttccaagt gtataatgtt ggtgtggagt 1140 tttcatgaca gaatatacac attttgtaaa tctgtacttt tttcaaatat tgaatgcctt 1200 atttttgaat tctttagatt tttaaattgg agaaaagcac ttaaagtttt ttatatatga 1260 atattacatg taaagctgtt aaaatacata acttcagtgc aagagacttt gtcacttatt 1320 tccttatgtg tgtaggaggg gttaataagt ctctagctct ccatctattg atagtttcat 1380 ttacaatttc aaaagaacat tcttatattt tatcaaggaa gtcttcaaat ttgattctaa 1440 atagcgatta taatctccaa ctttattttg aatgtacctc tattagtttc aattgagtaa 1500 ttctagacat aactggtttg actctgtcca actctgtatt taggccattt gttacagttt 1560 cttcatgcat tacttactgt taaaactgta ccttttgcga tttcacagtt ggcacttctg 1620 ccatgagcag agaactgatg cgacttgttt tgctgcttgg tagcacttta aaaaattttt 1680 tgattaatga agaaagtaaa accataaaca tttgccaaaa attcatgccc cagtattagc 1740 aatgaattag ttgcattggt ttgagaaagg cacatattgg agggaaatct tggtgtaact 1800 taaatatttg aaaattacct ttaatgcaat gcatatctgt ttattctggg aaatgtttta 1860 atgccagggc ctgctgagtt gcttcttctt gtggagattt tttttttaat ctcctgagtt 1920 gtataaaagt tgtactgcat cttagtttac tggataaatt taaaacacag tattgtagaa 1980 agctaataca aaactatcct atgccttcaa atagtataga aaatggaaaa tatacaagta 2040 aattctgttg aaccacctgt gtagtctctc tagtagttaa aacagctatt ttagtaaccc 2100 caagagtttc ttctcatatc cataaaattg gattacagta tggcaatatc tacagcttct 2160 attcattatg caacgtttaa cattgattgg ataaatgctt ataggctggg ccaggtggct 2220 cccacctgta gtcccagcac tttgggaggc aaaggcggga ggatcacttg aggccaggac 2280 tttgagacca gccagggcaa cataataaga cttttctcta ctttaaattt tttaaaaaat 2340 tagttgggca tagtggcact tgcctgtagt ctcagctact taggaggctg aggtggcaga 2400 atagcttatg cctaggaggt tgaggctgca gtgagctgtg attatgccat tgcactccag 2460 cctgggtgac agagcaatac cctgtcttta aaaataaaag ctattacttg gcaaattctg 2520 aggtaagtgt atgatcttag ggaactttga tacaaatggg aattcactca ctggaatcgt 2580 ggctcccaaa aagatgcttt aattgtgtgg tgcttttata gtttagctcc a 2631 <210> 314 <211> 459 <212> DNA <213> Homo sapiens <400> 314 atgtcgaccc cggcccggag gaggctcatg cgggatttca agcggttaca agaggaccca 60 cctgtgggtg tcagtggcgc accatctgaa aacaacatca tgcagtggaa tgcagttata 120 tttggaccag aagggacacc ttttgaagat ggtactttta aactagtaat agaattttct 180 gaagaatatc caaataaacc accaactgtt aggtttttat ccaaaatgtt tcatccaaat 240 gtgtatgctg atggtagcat atgtttagat atccttcaga atcgatggag tccaacatat 300 gatgtatctt ctatcttaac atcaattcag tctctgctgg atgaaccgaa tcctaacagt 360 ccagccaata gccaggcagc acagctttat caggaaaaca aacgagaata tgagaaaaga 420 gtttcggcca ttgttgaaca aagctggaat gattcatag 459 <210> 315 <211> 921 <212> DNA <213> Homo sapiens <400> 315 tttttttttt tcagactgac cgcggggcag ctgcggacat gtcgaccccg gcccggagga 60 ggctcatgcg ggatttcaag cggttacaag aggacccacc tgtgggtgtc agtggcgcac 120 catctgaaaa caacatcatg cagtggaatg cagttatatt tggaccagaa gggacacctt 180 ttgaagatgg tacttttaaa ctagtaatag aattttctga agaatatcca aataaaccac 240 caactgttag gtttttatcc aaaatgtttc atccaaatgt gtatgctgat ggtagcatat 300 gtttagatat ccttcagaat cgatggagtc caacatatga tgtatcttct atcttaacat 360 caattcagtc tctgctggat gaaccgaatc ctaacagtcc agccaatagc caggcagcac 420 agctttatca ggaaaacaaa cgagaatatg agaaaagagt ttcggccatt gttgaacaaa 480 gctggaatga ttcataatag acaactggtc tgttaatctt tttcatcatt gttgtgtata 540 atttacctct cattagaaag gctaacaaat tttaagtgcc acaggtttta aggattctgc 600 agaaaaaaaa gaaaaaagtc cttcagttta gaacctacaa aagcttgtgt atcttgatta 660 atgtactttt tattgcatgg tgtgaactaa gttattgctg cataaatttg taatatatcc 720 tgtttgtatt tttttccaag tgtataatgt tggtgtggag ttttcatgac agaatataca 780 cattttgtaa atctgtactt ttttcaaata ttgaatgcct tatttttgaa ttctttagat 840 ttttaaattg gagaaaagca cttaaagttt tttatatatg aatattacat gtaaagctgt 900 taaaatacat aacttcagtg c 921 <210> 316 <211> 2591 <212> DNA <213> Homo sapiens <400> 316 cgtccctctt tctccacccc gccgagccta aactagtgac ggggagggag acgggatagt 60 gtttctgttt ccgtggtctt tgaatccaca acctctagtc tgaacacaga gaacacaaat 120 ttgtcgatta cttcaggaag cccaggggga accgcgcccc gctgaagggc tcggggaagg 180 cgcgctcccg cgtcccgccc cctcctcccc cagcactcac actgtggtag cggcggaggg 240 cggagggatc cggaggcggc ggagggagac gtcattgcag ggttgtttgt cagtctcggc 300 ggcggcggcg gcggcggcgg cggcggcggc gatccacagt gattcggccg cgccgccggg 360 ggtggggggg ctgcgcggga cttttttttt tttcagactg accgcggggc agctgcggag 420 catgtcgacc ccggcccgga ggaggctcat gcgggatttc aagcggttac aagaggaccc 480 acctgtgggt gtcagtggcg caccatctga aaacaacatc atgcagtgga atgcagttat 540 atttggacca gaagggacac cttttgaaga tggtactttt aaactagtaa tagaattttc 600 tgaagaatat ccaaataaac caccaactgt taggttttta tccaaaatgt ttcatccaaa 660 tgtgtatgct gatggtagca tatgtttaga tatccttcag aatcgatgga gtccaacata 720 tgatgtatct tctatcttaa catcaattca gtctctgctg gatgaaccga atcctaacag 780 tccagccaat agccaggcag cacagcttta tcaggaaaac aaacgagaat atgagaaaag 840 agtttcggcc attgttgaac aaagctggaa tgattcataa tagacaactg gtctgttaat 900 ctttttcatc attgttgtgt ataatttacc tctcattaga aaggctaaca aattttaagt 960 gccacaggtt ttaaggattc tgcagaaaaa aaagaaaaaa gtccttcagt ttagaaccta 1020 caaaagcttg tgtatcttga ttaatgtact ttttattgca tggtgtgaac taagttattg 1080 ctgcataaat ttgtaatata tcctgtttgt atttttttcc aagtgtataa tgttggtgtg 1140 gagttttcat gacagaatat acacattttg taaatctgta cttttttcaa atattgaatg 1200 ccttattttt gaattcttta gatttttaaa ttggagaaaa gcacttaaag ttttttatat 1260 atgaatatta catgtaaagc tgttaaaata cataacttca gtgcaagaga ctttgtcact 1320 tatttcctta tgtgtgtagg aggggttaat aagtctctag ctctccatct attgatagtt 1380 tcatttacaa tttcaaaaga acattcttat attttatcaa ggaagtcttc aaatttgatt 1440 ctaaatagcg attataatct ccaactttat tttgaatgta cctctattag tttcaattga 1500 gtaattctag acataactgg tttgactctg tccaactctg tatttaggcc atttgttaca 1560 gtttcttcat gcattactta ctgttaaaac tgtacctttt gcgatttcac agttggcact 1620 tctgccatga gcagagaact gatgcgactt gttttgctgc ttggtagcac tttaaaaaat 1680 tttttgatta atgaagaaag taaaaccata aacattgcca aaaattcatg ccccagtatt 1740 agcaatgaat tagttgaatt ggtttgagaa aggcacatat tggagggaaa tcttggtgta 1800 acttaaatat ttgaaaatta cctttaatgc aatgcatatc tgtttattct gggaaatgtt 1860 ttaatgccag ggcctgctga gttgcttctt cttgtggaga tttttttttt aatctcctga 1920 gttgtataaa agttgtactg catcttagtt tactggataa atttaaaaca cagtattgta 1980 gaaagctaat acaaaactat cctatgcctt caaatagtat agaaaatgga aaatatacaa 2040 gtaaattctg ttgaaccacc tgtgtagtct ctctagtagt taaaacagct attttagtaa 2100 ccccaagagt ttcttctcat atccataaaa ttggattaca gtatggcaat atctacagct 2160 tctattcatt atgcaacgtt taacattgat tggataaatg cttataggct gggccaggtg 2220 gctcccacct gtagtcccag cactttggga ggcaaaggcg ggaggatcac ttgaggccag 2280 gactttgaga ccagccaggg caacataata agacttttct ctactttaaa ttttttaaaa 2340 aattagttgg gcatagtggc acttgcctgt agtctcagct acttaggagg ctgaggtggc 2400 agaatagctt atgcctagga ggttgaggct gcagtgagct gtgattatgc cattgcactc 2460 cagcctgggt gacagagcaa taccctgtct ttaaaaataa aagctattac ttggcaaaaa 2520 attccgcact atataattcg cacacattaa ttagggttta tgtaccatac aaaaaaaaat 2580 taattagggc t 2591 <210> 317 <211> 3053 <212> DNA <213> Homo sapiens <400> 317 agcgcgggga atttcgagtg gtgttggagc gccggaggct agtgggtggc tgacccccag 60 catcctcgag agcgaccatg gactccctgg ccgagtctcg gtggcctccg ggcctggcag 120 tcatgaagac aatagatgat ttgctgcggt gtggaatttg cttcgagtat ttcaacattg 180 caatgataat acctcagtgt tcacataact actgctctct ctgtataaga aaatttctgt 240 cctataaaac tcagtgtcca acttgctgtg tgactgtcac agagccggat ctgaaaaata 300 accgcatatt agatgaactg gtaaaaagct tgaattttgc acggaatcat ctgctgcagt 360 ttgctttaga gtcaccagcc aaatctcctg cttcttcctc ttcaaagaat cttgctgtca 420 aagtatatac tcctgtagcc tccagacagt ctttaaagca ggggagcagg ttaatggata 480 atttcttgat cagagaaatg agtggttcta catcagagtt gttgataaaa gaaaataaaa 540 gcaaattcag ccctcaaaaa gaggcgagcc ctgctgcaaa gaccaaagag acacgttctg 600 tagaagagat cgctccagat ccctcagagg ctaagcgtcc tgagccaccc tcgacatcca 660 ctttgaaaca agttactaaa gtggattgtc ctgtttgcgg ggttaacatt ccagaaagtc 720 acattaataa gcatttagac agctgtttat cacgcgaaga gaagaaggaa agcctcagaa 780 gttctgttca caaaaggaag ccgctgccca aaactgtata taatttgctc tctgatcgtg 840 atttaaagaa aaagctaaaa gagcatggat tatctattca aggaaataaa caacagctca 900 ttaaaaggca ccaagaattt gtacacatgt acaatgccca atgcgatgct ttgcatccta 960 aatcagctgc tgaaatagtt caagaaatcg aaaatataga gaagactagg atgcgtcttg 1020 aagctagtaa actcaatgaa agtgtaatgg tttttacaaa ggaccaaaca gaaaaggaaa 1080 tagatgaaat ccacagtaaa tatcgtaaaa aacataagag tgaatttcag cttctggtgg 1140 atcaggctag aaaaggatac aagaaaattg ctggaatgtc acaaaaaaca gtaacaataa 1200 caaaagaaga tgaatctaca gaaaagctat cttctgtatg catgggacag gaagataata 1260 tgacctcagt aacaaaccac ttttctcaat caaagctgga ctccccagag gaattggaac 1320 ctgacagaga agaggattct tctagctgta ttgatattca agaagttctt tcttcatcag 1380 aatcagattc atgcaatagt tccagttcag acatcataag agatctttta gaagaagagg 1440 aagcctggga agcatcacat aaaaacgatc ttcaagacac agaaataagt ccaagacaga 1500 atcgccgcac aagagccgct gaaagtgctg agattgaacc aagaaacaag cgtaatagga 1560 attaatgtgg gcttttgctg acttttcaaa tgcattgatt agaataccgt acttttggtt 1620 gccacagata gattttctat ttataaatgc ccaaggaaag atgctaaatt ctaaatatta 1680 cggttagctg atattcattc ttttctgctt ttccagaggg gaaaaatgtt acaaaatatc 1740 cttacttggt cagttgcctc ctgcctctaa aacatctctc tctaaaaata ctgacatttc 1800 acacaggtac cagctttgca gaggaggtag actctttggc actttggcac agggatttgg 1860 tttggtttgg tttggtttga taattaaatt tcagatagtc cttaggccat tctccttctc 1920 ttccatggag aatccagcct cacaaaagga ttctttcaac ttctttattg caagaaacag 1980 ttgagttaaa tgtttgtttt tggaaaggcg ggatgtcagt tcacatcctt ggtgtgtgta 2040 agtaccgatg cacgccacca ccatgcctgt gttacagcag ctccatgatg gttgttgccc 2100 gaggttaatg tagttgtttg ttagacctgt gtcttacaca tttctcagag taggatatta 2160 gtattataat ttaaagctac gacagtcaca aagtcacaat aacttagaaa cattgcgcat 2220 attcttctga aatagcactt aaaaatgatt agtgtcagta ttttttcact tgggtcaatc 2280 aaatctgtaa cactgaatcc aagctattaa acaaaaagta tgcaatgaat gaattttgta 2340 aatgaataga gagtatcagt ttacaataat gttcttaaaa cagtatcctc tggatagttg 2400 agtatgggtt agaaatcatt gaaatggatt ggtcagaaat tgctatctgt gtaaaatgtc 2460 taccagtagc cagatgcttc cagagttctt aatgcctctc tggcatttca gagccagcat 2520 cccccaactc ccacccctct gccatcaccc agcccaaaca catcagcttt caaatgagat 2580 gatagtaaat gcggcaatgt taagacaaga aatttatgat ttgccagatt caacatttat 2640 gacctcccct tccaaagact gtctccgttg accttgtctt tttggtatgc cttggggttt 2700 ctgataatgt gtggagtctc attatggctg agagtttagt gttttcacag tgaagtgcag 2760 acatttgatt tctttatgag ttccctgtgt tagaaatggc tatagaaaaa tttgtcataa 2820 taatttcatt tgcatgaaat cctgaggggt gcattaagga aactaaaagc accacttacc 2880 aaatctatcg gcagaactga tgtgaggtaa gtgagcatgt caaacaaaat aggagctcac 2940 atggatatat ttatgtcact gagttgtcag aaattatgtc aaaatgaaaa ctgtttgttt 3000 catgacaaat tatatagtct ataaattaaa ctggaagtaa ttattaaaaa aaa 3053 <210> 318 <211> 3046 <212> DNA <213> Homo sapiens <400> 318 ggaatttcga gtggtgttgg agcgccggag gctagtgggt ggctgacccc cagcatcctc 60 gagagcgacc atggactccc tggccgagtc tcggtggcct ccgggcctgg cagtcatgaa 120 gacaatagat gatttgctgc ggtgtggaat ttgcttcgag tatttcaaca ttgcaatgat 180 aatacctcag tgttcacata actactgctc tctctgtata agaaaatttc tgtcctataa 240 aactcagtgt ccaacttgct gtgtgactgt cacagagccg gatctgaaaa ataaccgcat 300 attagatgaa ctggtaaaaa gcttgaattt tgcacggaat catctgctgc agtttgcttt 360 agagtcacca gccaaatctc ctgcttcttc ctcttcaaag aatcttgctg tcaaagtata 420 tactcctgta gcctccagac agtctttaaa gcaggggagc aggttaatgg ataatttctt 480 gatcagagaa atgagtggtt ctacatcaga gttgttgata aaagaaaata aaagcaaatt 540 cagccctcaa aaagaggcga gccctgctgc aaagaccaaa gagacacgtt ctgtagaaga 600 gatcgctcca gatccctcag aggctaagcg tcctgagcca ctctcgacat ccactttgaa 660 acaagttact aaagtggatt gtcctgtttg cggggttaac attccagaaa gtcacattaa 720 taagcattta gacagctgtt tatcacgcga agagaagaag gaaagcctca gaagttctgt 780 tcacaaaagg aagccgctgc ccaaaactgt atataatttg ctctctgatc gtgatttaaa 840 gaaaaagcta aaagagcatg gattatctat tcaaggaaat aaacaacagc tcattaaaag 900 gcaccaagaa tttgtacaca tgtacaatgc ccaatgcgat gctttgcatc ctaaatcagc 960 tgctgaaata gttcaagaaa tcgaaaatat agagaagact aggatgcgtc ttgaagctag 1020 taaactcaat gaaagtgtaa tggtttttac aaaggaccaa acagaaaagg aaatagatga 1080 aatccacagt aaatatcgta aaaaacataa gagtgaattt cagcttctgg tggatcaggc 1140 tagaaaagga tacaagaaaa ttgctggaat gtcacaaaaa acagtaacaa taacaaaaga 1200 agatgaatct acagaaaagc tatcttctgt atgcatggga caggaagata atatgacctc 1260 agtaacaaac cacttttctc aatcaaagct ggactcccca gaggaattgg aacctgacag 1320 agaagaggat tcttctagct gtattgatat tcaagaagtt ctttcttcat cagaatcaga 1380 ttcatgcaat agttccagtt cagacatcat aagagatctt ttagaagaag aggaagcctg 1440 ggaagcatca cataaaaacg atcttcaaga cacagaaata agtccaagac agaatcgccg 1500 cacaagagcc gctggaaagt gctgagattg aaccaagaaa caagcgtaat aggaattaat 1560 gtgggctttt gctgactttt caaatgcatt gattagaata ccgtactttt ggttgccaca 1620 gatagatttt ctatttataa atgcccaagg aaagatgcta aattctaaat attacggtta 1680 gctgatattc attcttttct gcttttccag aggggaaaaa tgttacaaaa tatccttact 1740 tggtcagttg cctcctgcct ctaaaacatc tctctctaaa aatactgaca tttcacacag 1800 gtaccagctt tgcagaggag gtagactctt tggcactttg gcacagggat ttggtttggt 1860 ttggtttggt ttgataatta aatttcagat gtccttaggc cattctcctt ctcttccatg 1920 gagaatccag cctcacaaaa ggattctttc aacttcttta ttgcaagaaa cagttgagtt 1980 aaatgtttgt ttttggaaag gcgggatgtc agttcacatc cttggtgtgt gtaagtaccg 2040 atgcacgcca ccaccatgcc tgtgttacag cagctccatg atggttgttg cccgaggtta 2100 atgtagttgt ttgttagacc tgtgtcttac acatttctca gagtaggata ttagtattat 2160 aatttaaagc tacgacagtc acaaagtcac aataacttag aaacattgcg catattcttc 2220 tgaaatagca cttaaaaatg attagtgtca gtattttttc acttgggtca atcaaatctg 2280 taacactgaa tccaagctat taaacaaaaa gtatgcaatg aatgaatttt gtaaatgaat 2340 agagagtatc agtttacaat aatgttctta aaacagtatc ctctggatag ttgagtatgg 2400 gttagaaatc attgaaatgg attggtcaga aattgctatc tgtgtaaaat gtctaccagt 2460 agccagatgc ttccagagtt cttaatgcct ctctggcatt tcagagccag catcccccaa 2520 ctcccacccc tctgccatca cccagcccaa acacatcagc tttcaaatga gatgatagta 2580 aatgcggcaa tgttaagaca agaaatttat gatttgccag attcaacatt tatgacctcc 2640 ccttccaaag actgtctccg ttgaccttgt ctttttggta tgccttgggg tttctgataa 2700 tgtgtggagt ctcattatgg ctgagagttt agtgttttca cagtgaagtg cagacatttg 2760 atttctttat gagttccctg tgttagaaat ggctatagaa aaatttgtca taataatttc 2820 atttgcatga aatcctgagg ggtgcattaa ggaaactaaa agcaccactt accaaatcta 2880 tcggcagaac tgatgtgagg taagtgagca tgtcaaacaa aataggagct cacatggata 2940 tatttatgtc actgagttgt cagaaattat gtcaaaatga aaactgtttg tttcatgaca 3000 aattatatag tctataaatt aaactggaag taattattaa aaaaaa 3046 <210> 319 <211> 2653 <212> DNA <213> Homo sapiens <400> 319 agcgcgggga atttcgagtg gtgttggagc gccggaggct agtgggtggc tgacccccag 60 catcctcgag agcgaccatg gactccctgg ccgagtctcg gtggcctccg ggcctggcag 120 tcatgaagac aatagatgat ttgctgcggt gtggaatttg cttcgagtat ttcaacattg 180 caatgataat acctcagtgt tcacataact actgctctct ctgtataaga aaatttctgt 240 cctataaaac tcagtgtcca acttgctgtg tgactgtcac agagccggat ctgaaaaata 300 accgcatatt agatgaactg gtaaaaagct tgaattttgc acggaatcat ctgctgcagt 360 ttgctttaga gtcaccagcc aaatctcctg cttcttcctc ttcaaagaat cttgctgtca 420 aagtatatac tcctgtagcc tccagacagt ctttaaagca ggggagcagg ttaatggata 480 atttcttgat cagagaaatg agtggttcta catcagagtt gttgataaaa gaaaataaaa 540 gcaaattcag ccctcaaaaa gaggcgagcc ctgctgcaaa gaccaaagag acacgttctg 600 tagaagagat cgctccagat ccctcagagg ctaagcgtcc tgagccaccc tcgacatcca 660 ctttgaaaca agttactaaa gtggattgtc ctgtttgcgg ggttaacatt ccagaaagtc 720 acattaataa gcatttagac agctgtttat cacgcgaaga gaagaaggaa agcctcagaa 780 gttctgttca caaaaggaag ccgctgccca aaactgtata taatttgctc tctgatcgtg 840 atttaaagaa aaagctaaaa gagcatggat tatctattca aggaaataaa caacagctca 900 ttaaaaggca ccaagaattt gtacacatgt acaatgccca atgcgatgct ttgcatccta 960 aatcagctgc tgaaatagtt caagaaatcg aaaatataga gaagactagg atgcgtcttg 1020 aagctagtaa actcaatgaa agtgtaatgg tttttacaaa ggaccaaaca gaaaaggaaa 1080 tagatgaaat ccacagtaaa tatcgtaaaa aacataagag tgaatttcag cttctggtgg 1140 atcaggctag aaaaggatac aagaaaattg ctggaatgtc acaaaaaaca gtaacaataa 1200 caaaagaaga tgaatctaca gaaaagctat cttctgtatg catgggacag gaagataata 1260 tgacctcagt aacaaaccac ttttctcaat caaagctgga ctccccagag gaattggaac 1320 ctgacagaga agaggattct tctagctgta ttgatattca agaagttctt tcttcatcag 1380 aatcagattc atgcaatagt tccagttcag acatcataag agatctttta gaagaagagg 1440 aagcctggga agcatcacat aaaaacgatc ttcaagacac agaaataagt ccaagacaga 1500 atcgccgcac aagagccgct gaaagtgctg agattgaacc aagaaacaag cgtaatagga 1560 attaatgtgg gcttttgctg acttttcaaa tgcattgatt agaataccgt acttttggtt 1620 gccacagata gattttctat ttataaatgc ccaaggaaag atgctaaatt ctaaatatta 1680 cggttagctg atattcattc ttttctgctt ttccagaggg gaaaaatgtt acaaaatatc 1740 cttacttggt cagttgcctc ctgcctctaa aacatctctc tctaaaaata ctgacatttc 1800 acacaggtac cagctttgca gaggaggtag actctttggc actttggcac agggatttgg 1860 tttggtttgg tttggtttga taattaaatt tcagaatgtc cttaggccat tctccttctc 1920 ttccatggag aatccagcct cacaaaagga ttctttcaac ttctttattg caagaaacag 1980 ttgagttaaa tgtttgtttt tggaaaggcg ggatgtcagt tcacatcctt ggtgtgtgta 2040 agtaccgatg cacgccacca ccatgcctgt gttacagcag ctccatgatg gttgttgccc 2100 gaggttaatg tagttgtttg ttagacctgt gtcttacaca tttctcagag taggatatta 2160 gtattataat ttaaagctac gacagtcaca aagtcacaat aacttagaaa cattgcgcat 2220 attcttctga aatagcactt aaaaatgatt agtgtcagta ttttttcact tgggtcaatc 2280 aaatctgtaa cactgaatcc aagctattaa acaaaaagta tgcaatgaat gaattttgta 2340 aatgaataga gagtatcagt ttacaataat gttcttaaaa cagtatcctc tggatagttg 2400 agtatgggtt agaaatcatt gaaatggatt ggtcagaaat tgctatctgt gtaaaatgtc 2460 taccagtagc cagatgcttc cagagttctt aatgcctctc tggcatttca gagccagcat 2520 cccccaactc ccacccctct gccatcaccc agcccaaaca catcagcttt caaatgagat 2580 gatagtaaat gcggcaatgt taagacaaga aatttatgat ttgccagatt caacatttat 2640 gacctcccct tcc 2653 <210> 320 <211> 2890 <212> DNA <213> Homo sapiens <400> 320 ccctcgacct cgagatccat tgtgggcctg cgaggcctat cgctaggcct cgcggggaat 60 ttcgagtggt gttggagcgc cggaggctag tgggtggctg acccccagca tcctcgggag 120 cgaccatgga ctccctggcc gagtctcggt ggcctccggg cctggcagtc atgaagacaa 180 tagatgattt gctgcggtgt ggaatttgct tcgagtattt caacattgca atgataatac 240 ctcagtgttc acataactac tgctctctct gtataagaaa atttctgtcc tataaaactc 300 agtgtccaac ttgctgtgtg actgtcacag agccggatct gaaaaataac cgcatattag 360 atgaactggt aaaaagcttg aattttgcac ggaatcatct gctgcagttt gctttagagt 420 caccagccaa atctcctgct tcttcctctt caaagaatct tgctgtcaaa gtatatactc 480 ctgtagcctc cagacagtct ttaaagcagg ggagcaggtt aatggataat ttcttgatca 540 gagaaatgag tggttctaca tcagagttgt tgataaaaga aaataaaagc aaattcagcc 600 ctcaaaaaga ggcgagccct gctgcaaaga ccaaagagac acgttctgta gaagagatcg 660 ctccagatcc ctcagaggct aagcgtcctg agccaccctc gacatccact ttgaaacaag 720 ttactaaagt ggattgtcct gtttgcgggg ttaacattcc agaaagtcac attaataagc 780 atttagacag ctgtttatca cgcgaagaga agaaggaaag cctcagaagt tctgttcaca 840 aaaggaagcc gctgcccaaa actgtatata atttgctctc tgatcgtgat ttaaagaaaa 900 agctaaaaga gcatggatta tctattcaag gaaataaaca acagctcatt aaaaggcacc 960 aagaatttgt acacatgtac aatgcccaat gcgatgcttt gcatcctaaa tcagctgctg 1020 aaatagttca agaaatcgaa aatatagaga agactaggat gcgtcttgaa gctagtaaac 1080 tcaatgaaag tgtaatggtt tttacaaagg accaaacaga aaaggaaata gatgaaatcc 1140 acagtaaata tcgtaaaaaa cataagagtg aatttcagct tctggtggat caggctagaa 1200 aaggatacaa gaaaattgct ggaatgtcac aaaaaacagt aacaataaca aaagaagatg 1260 aatctacaga aaagctatct tctgtatgca tgggacagga agataatatg acctcagtaa 1320 caaaccactt ttctcaatca aagctggact ccccagagga attggaacct gacagagaag 1380 aggattcttc tagctgtatt gatattcaag aagttctttc ttcatcagaa tcagattcat 1440 gcaatagttc cagttcagac atcataagag atcttttaga agaagaggaa gcctgggaag 1500 catcacataa aaacgatctt caagacacag aaataagtcc aagacagaat cgccgcacaa 1560 gagccgctga aagtgctgag attgaaccaa gaaacaagcg taataggaat taatgtgggc 1620 ttttgctgac ttttcaaatg cattgattag aataccgtac ttttggttgc cacagataga 1680 ttttctattt ataaatgccc aaggaaagat gctaaattct aaatattacg gttagctgat 1740 attcattctt ttctgctttt ccagagggga aaaatgttac aaaatatcct tacttggtca 1800 gttgcctcct gcctctaaaa catctctctc taaaaatact gacatttcac acaggtacca 1860 gctttgcaga ggaggtaaac tctttggcac tttggcacag ggatttggtt tggtttggtt 1920 tggtttgata attaaatttc agaatgtcct taggccattc tccttctctt ccatggagaa 1980 tccagcctca caaaaggatt ctttcaactt ctttattgca agaaacagtt gagttaaatg 2040 tttgtttttg gaaaggcggg atgtcagttc acatccttgg tgtgtgtaag taccgatgca 2100 cgccaccacc atgcctgtgt tacagcagct ccatgatggt tgttgcccga ggttaatgta 2160 gttgtttgtt agacctgtgt cttacacatt tctcagagta ggatattagt attataattt 2220 aaagctacga cagtcacaaa gtcacaataa cttagaaaca ttgcgcatat tcttctgaaa 2280 tagcacttaa aaatgattag tgtcagtatt ttttcacttg ggtcaatcaa atctgtaaca 2340 ctgaatccaa gctattaaac aaaaagtatg caatgaatga attttgtaaa tgaatagaga 2400 gtatcagttt acaataatgt tcttaaaaca gtatcctctg gatagttgag tatgggttag 2460 aaatcattga aatggattgg tcagaaattg ctatctgtgt aaaatgtcta ccagtagcca 2520 gatgcttcca gagttcttaa tgcctctctg gcatttcaga gccagcatcc cccaactccc 2580 acccctctgc catcacccaa cccaaacaca tcagctttca aatgagatga tagtaaatgc 2640 ggcaatgtta agacaagaaa tttatgattt gccagattca acatttatga cctccccttc 2700 caaaaaaaaa aaaaaaaaaa gcggccgcga ctctagaact agtggatccc ccgggctgca 2760 ggaattcgat atcaagctta tcgataccgt cgacctcgag ggggggcccg gtacccagct 2820 tttgttccct ttagtgaggg ttaattgcgc gcttggcgta atcatggtca tagctgtttc 2880 ctgtgtgaaa 2890 <210> 321 <211> 1896 <212> DNA <213> Homo sapiens <400> 321 gtgttggagc gccggaggct agtgggtggc tgacccccag catcctcgag agcgaccatg 60 gactccctgg ccgagtctcg gtggcctccg ggcctggcag tcatgaagac aatagatgat 120 ttgctgcggt gtggaatttg cttcgagtat ttcaacattg caatgataat acctcagtgt 180 tcacataact actgctctct ctgtataaga aaatttctgt cctataaaac tcagtgtcca 240 acttgctgtg tgactgtcac agagccggat ctgaaaaata accgcatatt agatgaactg 300 gtaaaaagct tgaattttgc acggaatcat ctgctgcagt ttgctttaga gtcaccagcc 360 aaatctcctg cttcttcctc ttcaaagaat cttgctgtca aagtatatac tcctgtagcc 420 tccagacagt ctttaaagca ggggagcagg ttaatggata atttcttgat cagagaaatg 480 agtggttcta catcagagtt gttgataaaa gaaaataaaa gcaaattcag ccctcaaaaa 540 gaggcgagcc ctgctgcaaa gaccaaagag acacgttctg tagaagagat cgctccagat 600 ccctcagagg ctaagcgtcc tgagccaccc tcgacatcca ctttgaaaca agttactaaa 660 gtggattgtc ctgtttgcgg ggttaacatt ccagaaagtc acattaataa gcatttagac 720 agctgtttat cacgcgaaga gaagaaggaa agcctcagaa gttctgttca caaaaggaag 780 ccgctgccca aaactgtata taatttgctc tctgatcgtg atttaaagaa aaagctaaaa 840 gagcatggat tatctattca aggaaataaa caacagctca ttaaaaggca ccaagaattt 900 gtacacatgt acaatgccca atgcgatgct ttgcatccta aatcagctgc tgaaatagtt 960 caagaaatcg aaaatataga gaagactagg atgcgtcttg aagctagtaa actcaatgaa 1020 agtgtaatgg tttttacaaa ggaccaaaca gaaaaggaaa tagatgaaat ccacagtaaa 1080 tatcgtaaaa aacataagag tgaatttcag cttctggtgg atcaggctag aaaaggatac 1140 aagaaaattg ctggaatgtc acaaaaaaca gtaacaataa caaaagaaga tgaatctaca 1200 gaaaagctat cttctgtatg catgggacag gaagataata tgacctcagt aacaaaccac 1260 ttttctcaat caaagctgga ctccccagag gaattggaac ctgacagaga agaggattct 1320 tctagctgta ttgatattca agaagttctt tcttcatcag aatcagattc atgcaatagt 1380 tccagttcag acatcataag agatctttta gaagaagagg aagcctggga agcatcacat 1440 aaaaacgatc ttcaagacac agaaataagt ccaagacaga atcgccgcac aagagccgct 1500 gaaagtgctg agattgaacc aagaaacaag cgtaatagga attaatgtgg gcttttgctg 1560 acttttcaaa tgcattgatt agaataccgt acttttggtt gccacagata gattttctat 1620 ttataaatgc ccaaggaaag atgctaaatt ctaaatatta cggttagctg atattcattc 1680 ttttctgctt ttccagaggg gaaaaatgtt acaaaatatc cttacttggt cagttgcctc 1740 ctgcctctaa aacatctctc tctaaaaata ctgacatttc acacaggtac cagctttgca 1800 gaggaggtag actctttggc actttggcac agggatttgg tttggtttgg tttggtttga 1860 taattaaatt tcagaatgtc aaaaaaaaaa aaaaaa 1896 <210> 322 <211> 1669 <212> DNA <213> Homo sapiens <400> 322 gtgggtggct gacccccagc atcctcggga gcgaccatgg actccctggc cgagtctcgg 60 tggcctccgg gcctggcagt catgaagaca atagatgatt tgctgcggtg tggaatttgc 120 ttcgagtatt tcaacattgc aatgataata cctcagtgtt cacataacta ctgctctctc 180 tgtataagaa aatttctgtc ctataaaact cagtgtccaa cttgctgtgt gactgtcaca 240 gagccggatc tgaaaaataa ccgcatatta gatgaactgg taaaaagctt gaattttgca 300 cggaatcatc tgctgcagtt tgctttagag tcaccagcca aatctcctgc ttcttcctct 360 tcaaagaatc ttgctgtcaa agtatatact cctgtagcct ccagacagtc tttaaagcag 420 gggagcaggt taatggataa tttcttgatc agagaaatga gtggttctac atcagagttg 480 ttgataaaag aaaataaaag caaattcagc cctcaaaaag aggcgagccc tgctgcaaag 540 accaaagaga cacgttctgt agaagagatc gctccagatc cctcagaggc taagcgtcct 600 gagccaccct cgacatccac tttgaaacaa gttactaaag tggattgtcc tgtttgcggg 660 gttaacattc cagaaagtca cattaataag catttagaca gctgtttatc acgcgaagag 720 aagaaggaaa gcctcagaag ttctgttcac aaaaggaagc cgctgcccaa aactgtatat 780 aatttgctct ctgatcgtga tttaaagaaa aagctaaaag agcatggatt atctattcaa 840 ggaaataaac aacagctcat taaaaggcac caagaatttg tacacatgta caatgcccaa 900 tgcgatgctt tgcatcctaa atcagctgct gaaatagttc aagaaatcga aaatatagag 960 aagactagga tgcgtcttga agctagtaaa ctcaatgaaa gtgtaatggt ttttacaaag 1020 gaccaaacag aaaaggaaat agatgaaatc cacagtaaat atcgtaaaaa acataagagt 1080 gaatttcagc ttctggtgga tcaggctaga aaaggataca agaaaattgc tggaatgtca 1140 caaaaaacag taacaataac aaaagaagat gaatctacag aaaagctatc ttctgtatgc 1200 atgggacagg aagataatat gacctcagta acaaaccact tttctcaatc aaagctggac 1260 tccccagagg aattggaacc tgacagagaa gaggattctt ctagctgtat tgatattcaa 1320 gaagttcttt cttcatcaga atcagattca tgcaatagtt ccagttcaga catcataaga 1380 gatcttttag aagaagagga agcctgggaa gcatcacata aaaacgatct tcaagacaca 1440 gaaataagtc caagacagaa tcgccgcaca agagccgctg aaagtgctga gattgaacca 1500 agaaacaagc gtaataggaa ttaatgtggg cttttgctga cttttcaaat gcattgatta 1560 gaataccgta cttttggttg ccacagatag attttctatt tataaatgcc caaggaaaga 1620 tgctaaattc taaatattac ggttagctga taaaaaaaaa aaaaaaaaa 1669 <210> 323 <211> 1250 <212> DNA <213> Homo sapiens <400> 323 gtcccccgga agtggagccc gggacttcca ctcgtgcgtg aggcgagagg agccggagac 60 gagaccagag gccgaactcg ggttctgaca agatggccgg gctgccccgc aggatcatca 120 aggaaaccca gcgtttgctg gcagaaccag ttcctggcat caaagccgaa ccagatgaga 180 gcaacgcccg ttattttcat gtggtcattg ctggccctca ggattccccc tttgagggag 240 ggacttttaa acttgaacta ttccttccag aagaataccc aatggcagcc cctaaagtac 300 gtttcatgac caaaatttat catcctaatg tagacaagtt gggaagaata tgtttagata 360 ttttgaaaga taagtggtcc ccagcactgc agatccgcac agttctgcta tcgatccagg 420 ccttgttaag tgctcccaat ccagatgatc cattagcaaa tgatgtagcg gagcagtgga 480 agaccaacga agcccaagcc atagaaacag ctagagcatg gactaggcta tatgccatga 540 ataatattta aattgatacg atcatcaagt gtgcatcact tctcctgttc tgccaagact 600 tcctcctctt tgtttgcatt taatggacac agtcttagaa acattacaga ataaaaaagc 660 ccagacatct tcagtccttt ggtgattaaa tgcacattag caaatctatg tcttgtcctg 720 attcactgtc ataaagcatg agcagaggct agaagtatca tctggattgt tgtgaaacgt 780 ttaaaagcag tggcccctcc ctgcttttat tcatttcccc catcctggtt taagtataaa 840 gcactgtgaa tgaaggtagt tgtcaggtta gctgcagggg tgtgggtgtt tttattttat 900 tttattttat tttatttttg aggggggagg tagtttaatt ttatgggctc ctttccccct 960 tttttggtga tctaattgca ttggttaaaa gcagctaacc aggtctttag aatatgctct 1020 agccaagtct aactttattt agacgctgta gatggacaag cttgattgtt ggaaccaaaa 1080 tgggaacatt aaacaaacat cacagccctc actaataaca ttgctgtcaa gtgtagattc 1140 cccccttcaa aaaaagcttg tgaccatttt gtatggcttg tctggaaact tctgtaaatc 1200 ttatgtttta gtaaaatatt ttttgttatt ctaaaaaaaa aaaaaaaaaa 1250 <210> 324 <211> 1185 <212> DNA <213> Homo sapiens <400> 324 cagaggccga actcgggttc tgacaagatg gccgggctgc cccgcaggat catcaaggaa 60 acccagcgtt tgctggcaga accagttcct ggcatcaaag ccgaaccaga tgagagcaac 120 gcccgttatt ttcatgtggt cattgctggc cctcaggatt ccccctttga gggagggact 180 tttaaacttg aactattcct tccagaagaa tacccaatgg cagcccctaa agtacgtttc 240 atgaccaaaa tttatcatcc taatgtagac aagttgggaa gaatatgttt agatattttg 300 aaagataagt ggtccccagc actgcagatc cgcacagttc tgctatcgat ccaggccttg 360 ttaagtgctc ccaatccaga tgatccatta gcaaatgatg tagcggagca gtggaagacc 420 aacgaagccc aagccataga aacagctaga gcatggacta ggctatatgc catgaataat 480 atttaaattg atacgatcat caagtgtgca tcacttctcc tgttctgcca agacttcctc 540 ctctttgttt gcatttaatg gacacagtct tagaaacatt acagaataaa aaagcccaga 600 catcttcagt cctttggtga ttaaatgcac attagcaaat ctatgtcttg tcctgattca 660 ctgtcataaa gcatgagcag aggctagaag tatcatctgg attgttgtga aacgtttaaa 720 agcagtggcc cctccctgct tttattcatt tcccccatcc tggtttaagt ataaagcact 780 gtgaatgaag gtagttgtca ggttagctgc aggggtgtgg gtgtttttat tttattttat 840 tttattttat ttttgagggg ggaggtagtt taattttatg ggctcctttc cccctttttt 900 ggtgatctaa ttgcattggt taaaagcagc taaccaggtc tttagaatat gctctagcca 960 agtctaactt tatttagacg ctgtagatgg acaagcttga ttgttggaac caaaatggga 1020 acattaaaca aacatcacag ccctcactaa taacattgct gtcaagtgta gattcccccc 1080 ttcaaaaaaa gcttgtgacc attttgtatg gcttgtctgg aaacttctgt aaatcttatg 1140 ttttagtaaa atattttttg ttattctaaa aaaaaaaaaa aaaaa 1185 <210> 325 <211> 2568 <212> DNA <213> Homo sapiens <400> 325 cgcgcgcgca gtcgcgcgcg ggtcgtgccg taccaccgtc gcgggcaggc tcggccacga 60 gcgccagagc cccgcgcctc ccctcgcggc ctgtcccaag tccctgcccc gcaacagagc 120 gtcacttccg ccatccccgg cagcggttgg ggcggggcgc acgggggagg gggccaggtc 180 ggagggaagc ccgcccgtgc ccgagcccgc gcccgagcag ggactacatt tcccgagggg 240 cctcggcggc ggctgcggcg acgggcgcgg caacgtcccc cggaagtgga gcccgggact 300 tccactcgtg cgtgaggcga gaggagccgg agacgagacc agaggccgaa ctcgggttct 360 gacaagatgg ccgggctgcc ccgcaggatc atcaaggaaa cccagcgttt gctggcagaa 420 ccagttcctg gcatcaaagc cgaaccagat gagagcaacg cccgttattt tcatgtggtc 480 attgctggcc ctcaggattc cccctttgag ggagggactt ttaaacttga actattcctt 540 ccagaagaat acccaatggc agcccctaaa gtacgtttca tgaccaaaat ttatcatcct 600 aatgtagaca agttgggaag aatatgttta gatattttga aagataagtg gtccccagca 660 ctgcagatcc gcacagttct gctatcgatc caggccttgt taagtgctcc caatccagat 720 gatccattag caaatgatgt agcggagcag tggaagacca acgaagccca agccatagaa 780 acagctagag catggactag gctatatgcc atgaataata tttaaattga tacgatcatc 840 aagtgtgcat cacttctcct gttctgccaa gacttcctcc tctttgtttg catttaatgg 900 acacagtctt agaaacatta cagaataaaa aagcccagac atcttcagtc ctttggtgat 960 taaatgcaca ttagcaaatc tatgtcttgt cctgattcac tgtcataaag catgagcaga 1020 ggctagaagt atcatctgga ttgttgtgaa acgtttaaaa gcagtggccc ctccctgctt 1080 ttattcattt cccccatcct ggtttaagta taaagcactg tgaatgaagg tagttgtcag 1140 gttagctgca ggggtgtggg tgtttttatt ttattttatt ttattttatt tttgaggggg 1200 gaggtagttt aattttatgg gctcctttcc cccttttttg gtgatctaat tgcattggtt 1260 aaaagcagct aaccaggtct ttagaatatg ctctagccaa gtctaacttt atttagacgc 1320 tgtagatgga caagcttgat tgttggaacc aaaatgggaa cattaaacaa acatcacagc 1380 cctcactaat aacattgctg tcaagtgtag attcccccct tcaaaaaaag cttgtgacca 1440 ttttgtatgg cttgtctgga aacttctgta aatcttatgt tttagtaaaa tattttttgt 1500 tattctactt tgcctttgta cagtttattt tactgtgttt atttcatttt cccaatttga 1560 caatcgtatt ttaaaattga aactgatgga acattctttc ttggtcttca ccatctgaca 1620 aattgaatgg caagaggtgg attttgccag tttcttttca ctgatgcaga tttgtgttaa 1680 gatagtactg aatggagtat ttataaactg gccctgagca tgcataaagc atcagtatct 1740 gacctttttt taaccttcta ggaatttgaa ataaatgtgt ttgtgttgtc tgattagatg 1800 atcattggtg tcttgccaca atgtttaaaa attactgtac aggaaagtca cagcaaagat 1860 agcagttgtg actgacatgt aggactttca cagttgtgcc acatttttgc ctaaaatttg 1920 ggttatgaca tttttcttgg ttcttatctg aaaatttcat ctgtaacctt tcatgtgtgt 1980 taagaaacac tgatctgatc atttgggatt tgctgaggca tttgtgagtc ttccttataa 2040 acctgatgag cagatctcaa ctatctagct tgtgtgtcat cagaaaggtt tatccctttg 2100 agagtatcaa gtcctcagtt aatgattctt gctttcatcc ctccagtatt tgctgtggga 2160 gctcgtttta ttctttaatt tggaattcag taatttttct tctttattga cgaattcctc 2220 ccctcacaaa actgttcttt cccacctctc tccatatcta attcctgatt cttgttattt 2280 ttaagtcata aatgtagcca gtcataaata cataaatgtt aaccttcggg ttgcaacctt 2340 gtctcttgca gtttaaggta atggatattg tagcccattt gaattttctt cactcttatt 2400 ctcgtaattc tggagtttct tcagattgtg gtgtatttta ttgtgctcct atgtaagatg 2460 aagaattaac tattaaaatt acattttcaa catacaaaag cttttgatga ctggtaactg 2520 gtatccttcc aaataaatgc attgcttggt aaaaaaaaaa aaaaaaaa 2568 <210> 326 <211> 1203 <212> DNA <213> Homo sapiens <400> 326 actcgtgcgt gaggcgagag gagccggaga cgagaccaga ggccgaactc gggttctgac 60 aagatggccg ggctgccccg caggatcatc aaggaaaccc agcgtttgct ggcagaacca 120 gttcctggca tcaaagccga accagatgag agcaacgccc gttattttca tgtggtcatt 180 gctggccctc aggattcccc ctttgaggga gggactttta aacttgaact attccttcca 240 gaagaatacc caatggcagc ccctaaagta cgtttcatga ccaaaattta tcatcctaat 300 gtagacaagt tgggaagaat atgtttagat attttgaaag ataagtggtc cccagcactg 360 cagatccgca cagttctgct atcgatccag gccttgttaa gtgctcccaa tccagatgat 420 ccattagcaa atgatgtagc ggagcagtgg aagaccaacg aagcccaagc catagaaaca 480 gctagagcat ggactaggct atatgccatg aataatattt aaattgatac gatcatcaag 540 tgtgcatcac ttctcctgtt ctgccaagac ttcctcctct ttgtttgcat ttaatggaca 600 cagtcttaga aacattacag aataaaaaag cccagacatc ttcagtcctt tggtgattaa 660 atgcacatta gcaaatctat gtcttgtcct gattcactgt cataaagcat gagcagaggc 720 tagaagtatc atctggattg ttgtgaaacg tttaaaagca gtggcccctc cctgctttta 780 ttcatttccc ccatcctggt ttaagtataa agcactgtga atgaaggtag ttgtcaggtt 840 agctgcaggg gtgtgggtgt ttttatttta ttttatttta ttttattttt gaggggggag 900 gtagtttaat tttatgggct cctttccccc ttttttggtg atctaattgc attggttaaa 960 agcagctaac caggtcttta gaatatgctc tagccaagtc taactttatt tagacgctgt 1020 agatggacaa gcttgattgt tggaaccaaa atgggaacat taaacaaaca tcacagccct 1080 cactaataac attgctgtca agtgtagatt ccccccttca aaaaaagctt gtgaccattt 1140 tgtatggctt gtctggaaac ttctgtaaat cttatgtttt agtaaaatat tttttgttat 1200 tct 1203 <210> 327 <211> 459 <212> DNA <213> Homo sapiens <400> 327 atggccgggc tgccccgcag gatcatcaag gaaacccagc gtttgctggc agaaccagtt 60 cctggcatca aagccgaacc agatgagagc aacgcccgtt attttcatgt ggtcattgct 120 ggccctcagg attccccctt tgagggaggg acttttaaac ttgaactatt ccttccagaa 180 gaatacccaa tggcagcccc taaagtacgt ttcatgacca aaatttatca tcctaatgta 240 gacaagttgg gaagaatatg tttagatatt ttgaaagata agtggtcccc agcactgcag 300 atccgcacag ttctgctatc gatccaggcc ttgttaagtg ctcccaatcc agatgatcca 360 ttagcaaatg atgtagcgga gcagtggaag accaacgaag cccaagccat agaaacagct 420 agagcatgga ctaggctata tgccatgaat aatatttag 459 <210> 328 <211> 888 <212> DNA <213> Homo sapiens <400> 328 atggccgagc tgccccacag gatcatcaag gaaacccagc gtttgctggc agagccagtt 60 cctggcatca aagcagaacc agatgaaagc aacgcccgtt attttcatgt ggtcattgct 120 ggggaatcaa aggattcccc ctttgaggga gggactttta aacgtgaact attacttgca 180 gaagaatacc caatggcagc ccctaaagta cgtttcatga ccaaaattta tcatccaaat 240 gtagacaagt tggaaagaat aagtttagat attttgaaag ataagtggtc cccagccctg 300 cagatccgca cagttctgct atcgatccag gccttgttaa atgctcccaa tccagatgat 360 ccattagcaa atgatgtagt ggagcagtgg aagaccaacg aagcccaagc cattgaaaca 420 gctagagcat ggactaggct atatgccatg aatagtattt aaattgatcc aatcattaag 480 tgtgcatcac ttctcctgtt ctgccaagac ttcttccttt ttgcttgcat ttaatggaca 540 tagtcttaga aacattacag aataaaaaaa cccagacatc ttcagttatt tggtgattaa 600 atgtacatta gcaaatctat gtcttgtcct gattcactgt cataaagcat gagcagaggc 660 tagacgtatc atccggattg ttgtgaaacg tttaaaagca gtggtccctc cctgctttta 720 ttcatttccc ccatcctggt ttaagtataa agcactgtga atgaaggtag ttgtcaggtt 780 agctgcaagg gtgtgggtgt ttttctttat tttatttttt tgaggggggt aagtagtttt 840 attttaattt tatgggctcc tttccccgcc tttttggtga tctaattg 888 <210> 329 <211> 2929 <212> DNA <213> Homo sapiens <400> 329 aaacccagcg tttgctggca gaaccagttc ctggcatcaa agccgaacca gatgagagca 60 acgcccgtta ttttcatgtg gtcattgctg gccctcagga ttcccccttt gagggaggga 120 cttttaaact tgaactattc cttccagaag aatacccaat ggcagcccct aaagtacgtt 180 tcatgaccaa aatttatcat cctaatgtag acaagttggg aagaatatgt ttagatattt 240 tgaaaggtaa gtgttatctt tatcagcata tgctattatt aagctttctc ctttttctct 300 taagcattcc atgtttagaa tgtaaacatt atacaaagat cagagaggtc tgtgggaggg 360 aagtgaagca gttctgggcc tgtttttttc atgctttatc atactgggcc tgttgccttc 420 atagataagt ggtccccagc actgcagatc cgcacagttc tgctatcgat ccaggccttg 480 ttaagtgctc ccaatccaga tgatccatta gcaaatgatg tagcggagca gtggaagacc 540 aacgaagccc aagccataga aacaggtatc taatattcat tctccttcac accacttcca 600 cttttacaaa tttgtattac cacttaaact tttctaaagc tcttggcaag gaaaagaaat 660 agaaaaaagt ataataagtg agatcctgct tatagtatgt aaatacgtct taacaaaatg 720 gcttgctatg ggacccccca aatataaaga caacctgtaa ttgaaagatc ttggagtctc 780 ttgtaactac acctggttta acaaatactg agtgcatacc atttatctag ttatatgtaa 840 agaatactgg aaaacttgaa ctgtttttgt aacccatttg attaaagtat tcagctgttt 900 atggctacgg aatttggagt caagaagctt ctgctacaga ttttaagaaa attagtgggg 960 agaattgtgt atctagaaat ggacaacttg attcatcctc ttgaattttc tagaacttct 1020 taattttatt gtagtgtttt ggtaattgga catttacaaa atctttcagc cctgatccaa 1080 tttatagaaa aaggcgtgaa tttaacagat tacagcatga catttccata attaatagtg 1140 gttgtttgcc atttatagtt tggaaagtaa catattgaac taagtaaaat aataatcgta 1200 tgtttgtttc tgtctacagc tagagcatgg actaggctat atgccatgaa taatatttaa 1260 attgatacga tcatcaagtg tgcatcactt ctcctgttct gccaagactt cctcctcttt 1320 gtttgcattt aatggacaca gtcttagaaa cattacagaa taaaaaagcc cagacatctt 1380 cagtcctttg gtgattaaat gcacattagc aaatctatgt cttgtcctga ttcactgtca 1440 taaagcatga gcagaggcta gaagtatcat ctggattgtt gtgaaacgtt taaaagcggt 1500 ggcccctccc tgcttttatt catttccccc atcctggttt aagtataaag cactgtgaat 1560 gaaggtagtt gtcaggttag ctgcaggggt gtgggtgttt ttattttatt ttattttatt 1620 ttatttttga ggggggaggt agtttaattt tatgggctcc tttccccctt ttttggtgat 1680 ctaattgcat tggttaaaag cagctaacca ggtctttaga atatgctcta gccaagtcta 1740 actttattta gacgctgtag atggacaagc ttgattgttg gaaccaaaat gggaacatta 1800 aacaaacatc acagccctca ctaataacat tgctgtcaag tgtagattcc ccccttcaaa 1860 aaaaagcttg tgaccatttt gtatggcttg tctggaaact tctgtaaatc ttatgtttta 1920 gtaaaatatt ttttgttatt ctactttgcc tttgtacagt ttattttact gtgtttattt 1980 cattttccca atttgacaat cgtattttaa aattgaaact gatggaacat tctttcttgg 2040 tcttcaccat ctgacaaatt gaatggcaag aggtggattt tgccagtttc ttttcactga 2100 tgcagatttg tgttaagata gtactgaatg gagtatttat aaactggccc tgagcatgca 2160 taaagcatca gtatctgacc tttttttaac cttctaggaa tttgaaataa atgtgtttgt 2220 gttgtctgat tagatgatca ttggtgtctt gccacaatgt ttaaaaatta ctgtacagga 2280 aagtcacagc aaagatagca gttgtgactg acatgtagga ctttcacagt tgtgccacat 2340 ttttgcctaa aatttgggtt atgacatttt tcttggttct tatctgaaaa tttcatctgt 2400 aacctttcat gtgtgttaag aaacactgat ctgatcattt gggatttgct gaggcatttg 2460 tgagtcttcc ttataaacct gatgagcaga tctcaactat ctagcttgtg tgtcatcaga 2520 aaggtttatc cctttgagag tatcaagtcc tcagttaatg attcttgctt tcatccctcc 2580 agtatttgct gtgggagctc gttttattct ttaatttgga attcagtaat ttttcttctt 2640 tattgacgaa ttcctcccct cacaaaactg ttctttccca cctctctcca tatctaattc 2700 ctgattcttg ttatttttaa gtcataaatg tagccagtca taaatacata aatgttaacc 2760 ttcgggttgc aaccttgtct cttgcagttt aaggtaatgg atattgtagc ccatttgaat 2820 tttcttcact cttattctcg taattctgga gtttcttcag attgtggtgt attttattgt 2880 gctcctatgt aagatgaaga attaactatt aaaattacat tttcaacat 2929 <210> 330 <211> 3540 <212> DNA <213> Homo sapiens <400> 330 cagaggagga gctcgctgcc gggggacgct gggctgagcg gccggcggcg cgggcccggc 60 ggcggcggca gcggggtccg ggtccggagc gccacatgag acggtttaag cggaagcatc 120 ttactgccat tgactgccag catttggctc ggagtcactt ggctgtgacc cagcccttcg 180 gtcaaagatg gacaaacaga gatccgaacc atggtctcta tcctaaaccg agaacaaaaa 240 gagggagtag gggtcaggga agtcaaagat gcatccctga gttcttccta gcaggcaagc 300 agccgtgcac caatgacatg gccaaaagca attctgttgg ccaggacagc tgtcaggact 360 ctgagggtga catgatcttt cctgcagaga gcagctgtgc actgcctcag gaaggcagtg 420 cagggccggg ctcaccaggg tctgccccgc cctccaggaa gcggtcttgg tcctctgagg 480 aagagagtaa ccaggctacc gggaccagcc ggtgggatgg agtttctaag aaagctccac 540 ggcaccattt gtctgtgcca tgcacaaggc ctagggaggc caggcaagaa gcagaggaca 600 gtacgtctcg gctctctgcg gagtctggtg aaaccgacca agatgctggg gacgtgggtc 660 ctgatcccat tcctgactca tactatgggc ttcttgggac cttgccctgc caggaagcac 720 tgagccacat ttgcagcctg cctagtgagg tcctgaggca cgtgtttgcc ttcctcccgg 780 tggaagacct ctattggaac ctgagcttgg tgtgccactt gtggagggag atcatcagtg 840 acccgctgtt cattccttgg aagaagctgt accatcgata cctgatgaat gaagagcaag 900 ctgtcagcaa agtggacggc atcctgtcta actgtggcat agaaaaggag tcagacctgt 960 gtgtgctgaa cctcatacga tacacagcca ccactaagtg ctctccgagt gtggatcccg 1020 agagggtgct gtggagtctg agggaccacc ccctcctccc cgaggctgag gcgtgtgtgc 1080 ggcaacacct ccccgacctc tacgctgctg ccgggggtgt caacatctgg gccctggtgg 1140 cggctgtggt gctcctctcc agcagtgtga atgacatcca gcgactgctc ttctgcctcc 1200 ggagacccag ctccacggtg accatgccag atgtcaccga gaccctgtac tgcatagccg 1260 tgcttctcta cgccatgagg gagaagggga ttaacatcag caataggatt cactacaaca 1320 ttttctattg cctatatctt caggagaatt cctgcactca ggccacaaaa gttaaagagg 1380 agccatctgt ctggccaggc aagaaaacca tccaacttac acatgaacaa cagctgattc 1440 tgaatcacaa gatggaacct ctccaggtgg tgaaaattat ggcctttgcc ggcactggga 1500 agacctcaac gctggtcaag tatgcagaga agtggtctca gagcaggttt ctgtatgtga 1560 cattcaacaa gagcatcgca aagcaggccg aacgcgtctt ccccagcaac gtcatctgca 1620 aaaccttcca ctccatggcc tacgggcaca tagggcggaa gtaccagtca aagaagaagt 1680 tgaatctctt caagttaaca cccttcatgg tcaactccgt ccttgctgaa gggaagggtg 1740 gattcataag agccaagctt gtgtgtaaga ctctagaaaa cttctttgcc tcggctgacg 1800 aagagctgac cattgatcac gtgcctattt ggtgtaagaa cagccaagga cagagagtca 1860 tggttgagca gagtgaaaaa ctgaatggtg tccttgaagc gagccgcctc tgggataaca 1920 tgcggaagct gggggagtgc acagaagagg cgcaccagat gactcatgac ggctacttga 1980 aactctggca gctgagcaag ccttcgctgg cctcttttga cgccatcttt gtggatgagg 2040 cccaggactg cacaccagct atcatgaaca tagttctgtc tcagccatgt gggaaaatct 2100 ttgtagggga cccgcaccag cagatctata ccttccgggg tgcggtcaac gccctgttca 2160 cagtgcccca cacccacgtc ttctatctca cgcagagttt tcggtttggt gtggaaatag 2220 cttatgtggg agctactatc ttggatgttt gcaagagagt caggaaaaag actttggttg 2280 gaggaaacca tcagagtggc attagaggtg acgcaaaggg gcaagtggcc ttgttgtccc 2340 ggaccaacgc caacgtgttt gatgaggccg tacgggtgac ggaaggggaa ttcccttcaa 2400 ggatacattt gattgggggg attaaatcat ttggattgga cagaatcatt gatatttgga 2460 tccttcttca gccagaggaa gaacggagga aacaaaacct cgtcattaaa gacaaattta 2520 tcagaagatg ggtgcacaaa gaaggcttta gtggcttcaa gaggtatgtg accgctgccg 2580 aggacaagga gcttgaagcc aagatcgcag ttgttgaaaa gtataacatc aggattccag 2640 agctggtgca aaggatagaa aaatgccata tagaagattt ggactttgca gagtacattc 2700 tgggcactgt gcacaaagcc aaaggcctgg agtttgacac tgtgcatgtt ttggatgatt 2760 ttgtgaaagt gccttgtgcc cggcataacc tgccccagct tccgcacttc agagttgagt 2820 cattttctga ggatgaatgg aatttactgt atgttgcagt aactcgagcc aagaagcgtc 2880 tcatcatgac caaatcattg gaaaacattt tgactttggc tggggagtac ttcttgcaag 2940 cagagctgac aagcaacgtc ttaaaaacag gcgtggtgcg ctgctgcgtg ggacagtgca 3000 acaatgccat ccctgttgac accgtcctta ccatgaagaa gctgcccatc acctatagca 3060 acaggaagga aaacaagggg ggctacctct gccactcctg tgcggagcag cgcatcgggc 3120 ccctggcgtt cctgacagcc tccccggagc aggtgcgcgc catggagcgc actgtggaga 3180 acatcgtact gccccggcat gaggccctgc tcttcctcgt cttctgagga caaggcgcac 3240 gttctccgca gtgcagagca gcttgccgag gaccccgcgt gaagaaagcc agcgaggggg 3300 gcttctgctc cctgagactc tgggttcacc cacagcactt tctgaggaag aggacaccag 3360 cccaagctgg acctgccatt tctccactcc ctacagacag ccagtctcca cttgcctccc 3420 ctctggatgt atctggtcag ggaagtgggg gatgttcttt tgataaaaaa aaaaaaaaaa 3480 atttatgtat ttaaactttt attacaagat ttcaattaaa caggcaccat agcactggca 3540 <210> 331 <211> 3727 <212> DNA <213> Homo sapiens <400> 331 ctgctttcaa ggtgtctaga tacagagtga agaatgtcac agtaggaagt gcactggact 60 aggggagtca ggagacccgg gttcttgtgt tggcaccatc actcatgagc tacgaggtga 120 cttcaggctg ccattggacc tgtcaagtgc ctgagtcatg tgataatggg ctacattgcg 180 cagggcccct gggccatctc cacaggagat gccagaggac gagtgcccac ttgctggtct 240 tcacagagca cgctgaaatg agacggttta agcggaagca tcttactgcc attgactgcc 300 agcatttggc tcggagtcac ttggctgtga cccagccctt cggtcaaaga tggacaaaca 360 gagatccgaa ccatggtctc tatcctaaac cgagaacaaa aagagggagt aggggtcagg 420 gaagtcaaag atgcatccct gagttcttcc tagcaggcaa gcagccgtgc accaatgaca 480 tggccaaaag caattctgtt ggccaggaca gctgtcagga ctctgagggt gacatgatct 540 ttcctgcaga gagcagctgt gcactgcctc aggaaggcag tgcagggccg ggctcaccag 600 ggtctgcccc gccctccagg aagcggtctt ggtcctctga ggaagagagt aaccaggcta 660 ccgggaccag ccggtgggat ggagtttcta agaaagctcc acggcaccat ttgtctgtgc 720 catgcacaag gcctagggag gccaggcaag aagcagagga cagtacgtct cggctctctg 780 cggagtctgg tgaaaccgac caagatgctg gggacgtggg tcctgatccc attcctgact 840 catactatgg gcttcttggg accttgccct gccaggaagc actgagccac atttgcagcc 900 tgcctagtga ggtcctgagg cacgtgtttg ccttcctccc ggtggaagac ctctattgga 960 acctgagctt ggtgtgccac ttgtggaggg agatcatcag tgacccgctg ttcattcctt 1020 ggaagaagct gtaccatcga tacctgatga atgaagagca agctgtcagc aaagtggacg 1080 gcatcctgtc taactgtggc atagaaaagg agtcagacct gtgtgtgctg aacctcatac 1140 gatacacagc caccactaag tgctctccga gtgtggatcc cgagagggtg ctgtggagtc 1200 tgagggacca ccccctcctc cccgaggctg aggcgtgtgt gcggcaacac ctccccgacc 1260 tctacgctgc tgccgggggt gtcaacatct gggccctggt ggcggctgtg gtgctcctct 1320 ccagcagtgt gaatgacatc cagcgactgc tcttctgcct ccggagaccc agctccacgg 1380 tgaccatgcc agatgtcacc gagaccctgt actgcatagc cgtgcttctc tacgccatga 1440 gggagaaggg gattaacatc agcaatagga ttcactacaa cattttctat tgcctatatc 1500 ttcaggagaa ttcctgcact caggccacaa aagttaaaga ggagccatct gtctggccag 1560 gcaagaaaac catccaactt acacatgaac aacagctgat tctgaatcac aagatggaac 1620 ctctccaggt ggtgaaaatt atggcctttg ccggcactgg gaagacctca acgctggtca 1680 agtatgcaga gaagtggtct cagagcaggt ttctgtatgt gacattcaac aagagcatcg 1740 caaagcaggc cgaacgcgtc ttccccagca acgtcatctg caaaaccttc cactccatgg 1800 cctacgggca catagggcgg aagtaccagt caaagaagaa gttgaatctc ttcaagttaa 1860 cacccttcat ggtcaactcc gtccttgctg aagggaaggg tggattcata agagccaagc 1920 ttgtgtgtaa gactctagaa aacttctttg cctcggctga cgaagagctg accattgatc 1980 acgtgcctat ttggtgtaag aacagccaag gacagagagt catggttgag cagagtgaaa 2040 aactgaatgg tgtccttgaa gcgagccgcc tctgggataa catgcggaag ctgggggagt 2100 gcacagaaga ggcgcaccag atgactcatg acggctactt gaaactctgg cagctgagca 2160 agccttcgct ggcctctttt gacgccatct ttgtggatga ggcccaggac tgcacaccag 2220 ctatcatgaa catagttctg tctcagccat gtgggaaaat ctttgtaggg gacccgcacc 2280 agcagatcta taccttccgg ggtgcggtca acgccctgtt cacagtgccc cacacccacg 2340 tcttctatct cacgcagagt tttcggtttg gtgtggaaat agcttatgtg ggagctacta 2400 tcttggatgt ttgcaagaga gtcaggaaaa agactttggt tggaggaaac catcagagtg 2460 gcattagagg tgacgcaaag gggcaagtgg ccttgttgtc ccggaccaac gccaacgtgt 2520 ttgatgaggc cgtacgggtg acggaagggg aattcccttc aaggatacat ttgattgggg 2580 ggattaaatc atttggattg gacagaatca ttgatatttg gatccttctt cagccagagg 2640 aagaacggag gaaacaaaac ctcgtcatta aagacaaatt tatcagaaga tgggtgcaca 2700 aagaaggctt tagtggcttc aagaggtatg tgaccgctgc cgaggacaag gagcttgaag 2760 ccaagatcgc agttgttgaa aagtataaca tcaggattcc agagctggtg caaaggatag 2820 aaaaatgcca tatagaagat ttggactttg cagagtacat tctgggcact gtgcacaaag 2880 ccaaaggcct ggagtttgac actgtgcatg ttttggatga ttttgtgaaa gtgccttgtg 2940 cccggcataa cctgccccag cttccgcact tcagagttga gtcattttct gaggatgaat 3000 ggaatttact gtatgttgca gtaactcgag ccaagaagcg tctcatcatg accaaatcat 3060 tggaaaacat tttgactttg gctggggagt acttcttgca agcagagctg acaagcaacg 3120 tcttaaaaac aggcgtggtg cgctgctgcg tgggacagtg caacaatgcc atccctgttg 3180 acaccgtcct taccatgaag aagctgccca tcacctatag caacaggaag gaaaacaagg 3240 ggggctacct ctgccactcc tgtgcggagc agcgcatcgg gcccctggcg ttcctgacag 3300 cctccccgga gcaggtgcgc gccatggagc gcactgtgga gaacatcgta ctgccccggc 3360 atgaggccct gctcttcctc gtcttctgag gacaaggcgc acgttctccg cagtgcagag 3420 cagcttgccg aggaccccgc gtgaagaaag ccagcgaggg gggcttctgc tccctgagac 3480 tctgggttca cccacagcac tttctgagga agaggacacc agcccaagct ggacctgcca 3540 tttctccact ccctacagac agccagtctc cacttgcctc ccctctggat gtatctggtc 3600 agggaagtgg gggatgttct tttgataaaa aaaaaaaaaa aaatttatgt atttaaactt 3660 ttattacaag atttcaatta aacaggcacc atagcactgg caaaaaaaaa aaaaaaaaaa 3720 aaaaaaa 3727 <210> 332 <211> 3726 <212> DNA <213> Homo sapiens <400> 332 ctgctttcaa ggtgtctaga tacagagtga agaatgtcac agtaggaagt gcactggact 60 aggggagtca ggagacccgg gttcttgtgt tggcaccatc actcatgagc tacgaggtga 120 cttcaggctg ccattggacc tgtcaagtgc ctgagtcatg tgataatggg ctacattgcg 180 cagggcccct gggccatctc cacaggagat gccagaggac gagtgcccac ttgctggtct 240 tcacagagca cgctgaaatg agacggttta agcggaagca tcttactgcc attgactgcc 300 agcatttggc tcggagtcac ttggctgtga cccagccctt cggtcaaaga tggacaaaca 360 gagatccgaa ccatggtctc tatcctaaac cgagaacaaa aagagggagt aggggtcagg 420 gaagtcaaag atgcatccct gagttcttcc tagcaggcaa gcagccgtgc accaatgaca 480 tggccaaaag caattctgtt ggccaggaca gctgtcagga ctctgagggt gacatgatct 540 ttcctgcaga gagcagctgt gcactgcctc aggaaggcag tgcagggccg ggctcaccag 600 ggtctgcccc gccctccagg aagcggtctt ggtcctctga ggaagagagt aaccaggcta 660 ccgggaccag ccggtgggat ggagtttcta agaaagctcc acggcaccat ttgtctgtgc 720 catgcacaag gcctagggag gccaggcaag aagcagagga cagtacgtct cggctctctg 780 cggagtctgg tgaaaccgac caagatgctg gggacgtggg tcctgatccc attcctgact 840 catactatgg gcttcttggg accttgccct gccaggaagc actgagccac atttgcagcc 900 tgcctagtga ggtcctgagg cacgtgtttg ccttcctccc ggtggaagac ctctattgga 960 acctgagctt ggtgtgccac ttgtggaggg agatcatcag tgacccgctg ttcattcctt 1020 ggaagaagct gtaccatcga tacctgatga atgaagagca agctgtcagc aaagtggacg 1080 gcatcctgtc taactgtggc atagaaaagg agtcagacct gtgtgtgctg aacctcatac 1140 gatacacagc caccactaag tgctctccga gtgtggatcc cgagagggtg ctgtggagtc 1200 tgagggacca ccccctcctc cccgaggctg aggcgtgtgt gcggcaacac ctccccgacc 1260 tctacgctgc tgccgggggt gtcaacatct gggccctggt ggcggctgtg gtgctcctct 1320 ccagcagtgt gaatgacatc cagcgactgc tcttctgcct ccggagaccc agctccacgg 1380 tgaccatgcc agatgtcacc gagaccctgt actgcatagc cgtgcttctc tacgccatga 1440 gggagaaggg gattaacatc agcaatagga ttcactacaa cattttctat tgcctatatc 1500 ttcaggagaa ttcctgcact caggccacaa aagttaaaga ggagccatct gtctggccag 1560 gcaagaaaac catccaactt acacatgaac aacagctgat tctgaatcac aagatggaac 1620 ctctccaggt ggtgaaaatt atggcctttg ccggcactgg gaagacctca acgctggtca 1680 agtatgcaga gaagtggtct cagagcaggt ttctgtatgt gacattcaac aagagcatcg 1740 caaagcaggc cgaacgcgtc ttccccagca acgtcatctg caaaaccttc cactccatgg 1800 cctacgggca catagggcgg aagtaccagt caaagaagaa gttgaatctc ttcaagttaa 1860 cacccttcat ggtcaactcc gtccttgctg aagggaaggg tggattcata agagccaagc 1920 ttgtgtgtaa gactctagaa aacttctttg cctcggctga cgaagagctg accattgatc 1980 acgtgcctat ttggtgtaag aacagccaag gacagagagt catggttgag cagagtgaaa 2040 aactgaatgg tgtccttgaa gcgagccgcc tctgggataa catgcggaag ctgggggagt 2100 gcacagaaga ggcgcaccag atgactcatg acggctactt gaaactctgg cagctgagca 2160 agccttcgct ggcctctttt gacgccatct ttgtggatga ggcccaggac tgcacaccag 2220 ctatcatgaa catagttctg tctcagccat gtgggaaaat ctttgtaggg gacccgcacc 2280 agcagatcta taccttccgg ggtgcggtca acgccctgtt cacagtgccc cacacccacg 2340 tcttctatct cacgcagagt tttcggtttg gtgtggaaat agcttatgtg ggagctacta 2400 tcttggatgt ttgcaagaga gtcaggaaaa agactttggt tggaggaaac catcagagtg 2460 gcattagagg tgacgcaaag gggcaagtgg ccttgttgtc ccggaccaac gccaacgtgt 2520 ttgatgaggc cgtacgggtg acggaagggg aattcccttc aaggatacat ttgattgggg 2580 ggattaaatc atttggattg gacagaatca ttgatatttg gatccttctt cagccagagg 2640 aagaacggag gaaacaaaac ctcgtcatta aagacaaatt tatcagaaga tgggtgcaca 2700 aagaaggctt tagtggcttc aagaggtatg tgaccgctgc cgaggacaag gagcttgaag 2760 ccaagatcgc agttgttgaa aagtataaca tcaggattcc agagctggtg caaaggatag 2820 aaaaatgcca tatagaagat ttggactttg cagagtacat tctgggcact gtgcacaaag 2880 ccaaaggcct ggagtttgac actgtgcatg ttttggatga ttttgtgaaa gtgccttgtg 2940 cccggcataa cctgccccag cttccgcact tcagagttga gtcattttct gaggatgaat 3000 ggaatttact gtatgttgca gtaactcgag ccaagaagcg tctcatcatg accaaatcat 3060 tggaaaacat tttgactttg gctggggagt acttcttgca agcagagctg acaagcaacg 3120 tcttaaaaac aggcgtggtg cgctgctgcg tgggacagtg caacaatgcc atccctgttg 3180 acaccgtcct taccatgaag aagctgccca tcacctatag caacaggaag gaaaacaagg 3240 ggggctacct ctgccactcc tgtgcggagc agcgcatcgg gcccctggcg ttcctgacag 3300 cctccccgga gcaggtgcgc gccatggagc gcactgtgga gaacatcgta ctgccccggc 3360 atgaggccct gctcttcctc gtcttctgag gacaaggcgc acgttctccg cagtgcagag 3420 cagcttgccg aggaccccgc gtgaagaaag ccagcgaggg gggcttctgc tccctgagac 3480 tctgggttca cccacagcac tttctgagga agaggacacc agcccaagct ggacctgcca 3540 tttctccact ccctacagac agccagtctc cacttgcctc ccctctggat gtatctggtc 3600 agggaagtgg gggatgttct tttgataaaa aaaaaaaaaa attttatgta tttaaacttt 3660 tattacaaga tttcaattaa acaggcacca tagcactggc aaaaaaaaaa aaaaaaaaaa 3720 aaaaaa 3726 <210> 333 <211> 3584 <212> DNA <213> Homo sapiens <400> 333 agcggagcgg aggagctcgc tgccggggga cgctgggctg agcggccggc ggcgcgggcc 60 cggcggcggc ggcagcgggg tccgggtccg gagcgccaca tgagacggtt taagcggaag 120 catcttactg ccattgactg ccagcatttg gctcggagtc acttggctgt gacccagccc 180 ttcggtcaaa gatggacaaa cagagatccg aaccatggtc tctatcctaa accgagaaca 240 aaaagaggga gtaggggtca gggaagtcaa agatgcatcc ctgagttctt cctagcaggc 300 aagcagccgt gcaccaatga catggccaaa agcaattctg ttggccagga cagctgtcag 360 gactctgagg gtgacatgat ctttcctgca gagagcagct gtgcactgcc tcaggaaggc 420 agtgcagggc cgggctcacc agggtctgcc ccgccctcca ggaagcggtc ttggtcctct 480 gaggaagaga gtaaccaggc taccgggacc agccggtggg atggagtttc taagaaagct 540 ccacggcacc atttgtctgt gccatgcaca aggcctaggg aggccaggca agaagcagag 600 gacagtacgt ctcggctctc tgcggagtct ggtgaaaccg accaagatgc tggggacgtg 660 ggtcctgatc ccattcctga ctcatactat gggcttcttg ggaccttgcc ctgccaggaa 720 gcactgagcc acatttgcag cctgcctagt gaggtcctga ggcacgtgtt tgccttcctc 780 ccggtggaag acctctattg gaacctgagc ttggtgtgcc acttgtggag ggagatcatc 840 agtgacccgc tgttcattcc ttggaagaag ctgtaccatc gatacctgat gaatgaagag 900 caagctgtca gcaaagtgga cggcatcctg tctaactgtg gcatagaaaa ggagtcagac 960 ctgtgtgtgc tgaacctcat acgatacaca gccaccacta agtgctctcc gagtgtggat 1020 cccgagaggg tgctgtggag tctgagggac caccccctcc tccccgaggc tgaggcgtgt 1080 gtgcggcaac acctccccga cctctacgct gctgccgggg gtgtcaacat ctgggccctg 1140 gtggcggctg tggtgctcct ctccagcagt gtgaatgaca tccagcgact gctcttctgc 1200 ctccggagac ccagctccac ggtgaccatg ccagatgtca ccgagaccct gtactgcata 1260 gccgtgcttc tctacgccat gagggagaag gggattaaca tcagcaatag gattcactac 1320 aacattttct attgcctata tcttcaggag aattcctgca ctcaggccac aaacgttaaa 1380 gaggagccat ctgtctggcc aggcaagaaa accatccaac ttacacatga acaacagctg 1440 attctgaatc acaagatgga acctctccag gtggtgaaaa ttatggcctt tgccggcact 1500 gggaagacct caacgctggt caagtatgca gagaagtggt ctcagagcag gtttctgtat 1560 gtgacattca acaagagcat cgcaaagcag gccgaacgcg tcttccccag caacgtcatc 1620 tgcaaaacct tccactccat ggcctacggg cacatagggc ggaagtacca gtcaaagaag 1680 aagttgaatc tcttcaagtt aacacccttc atggtcaact ccgtccttgc tgaagggaag 1740 ggtggattca taagagccaa gcttgtgtgt aagactctag aaaacttctt tgcctcggct 1800 gacgaagagc tgaccattga tcacgtgcct atttggtgta agaacagcca aggacagaga 1860 gtcatggttg agcagagtga aaaactgaat ggtgtccttg aagcgagccg cctctgggat 1920 aacatgcgga agctggggga gtgcacagaa gaggcgcacc agatgactca tgacggctac 1980 ttgaaactct ggcagctgag caagccttcg ctggcctctt ttgacgccat ctttgtggat 2040 gaggcccagg actgcacacc agctatcatg aacatagttc tgtctcagcc atgtgggaaa 2100 atctttgtag gggacccgca ccagcagatc tataccttcc ggggtgcggt caacgccctg 2160 ttcacagtgc cccacaccca cgtcttctat ctcacgcaga gttttcggtt tggtgtggaa 2220 atagcttatg tgggagctac tatcttggat gtttgcaaga gagtcaggaa aaagactttg 2280 gttggaggaa accatcagag tggcattaga ggtgacgcaa aggggcaagt ggccttgttg 2340 tcccggacca acgccaacgt gtttgatgag gccgtacggg tgacggaagg ggaattccct 2400 tcaaggatac atttgattgg ggggattaaa tcatttggat tggacagaat cattgatatt 2460 tggatccttc ttcagccaga ggaagaacgg aggaaacaaa acctcgtcat taaagacaaa 2520 tttatcagaa gatgggtgca caaagaaggc tttagtggct tcaagaggta tgtgaccgct 2580 gccgaggaca aggagcttga agccaagatc gcagttgttg aaaagtataa catcaggatt 2640 ccagagctgg tgcaaaggat agaaaaatgc catatagaag atttggactt tgcagagtac 2700 attctgggca ctgtgcacaa agccaaaggc ctggagtttg acactgtgca tgttttggat 2760 gattttgtga aagtgccttg tgcccggcat aacctgcccc agcttccgca cttcagagtt 2820 gagtcatttt ctgaggatga atggaattta ctgtatgttg cagtaactcg agccaagaag 2880 cgtctcatca tgaccaaatc attggaaaac attttgactt tggctgggga gtacttcttg 2940 caagcagagc tgacaagcaa cgtcttaaaa acaggcgtgg tgcgctgctg cgtgggacag 3000 tgcaacaatg ccatccctgt tgacaccgtc cttaccatga agaagctgcc catcacctat 3060 agcaacagga aggaaaacaa ggggggctac ctctgccact cctgtgcgga gcagcgcatc 3120 gggcccctgg cgttcctgac agcctccccg gagcaggtgc gcgccatgga gcgcactgtg 3180 gagaacatcg tactgccccg gcatgaggcc ctgctcttcc tcgtcttctg aggacaaggc 3240 gcacgttctc cgcagtgcag agcagcttgc cgaggacccc gcgtgaagaa agccagcgag 3300 gggggcttct gctccctgag actctgggtt cacccacagc actttctgag gaagaggaca 3360 ccagcccaag ctggacctgc catttctcca ctccctacag acagccagtc tccacttgcc 3420 tcccctctgg atgtatctgg tcagggaagt gggggatgtt cttttgataa aaaaaaaaaa 3480 aattttatgt atttaaactt ttattacaag atttcaatta aacaggcacc atagcactgg 3540 caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa 3584 <210> 334 <211> 3560 <212> DNA <213> Homo sapiens <400> 334 cactcgggct ccaggtcccg gccagaggag gagctcgctg ccgggggacg ctgggctgag 60 cggccggcgg cgcgggcccg gcggcggcgg cagcggggtc cgggtccgga gcgccacatg 120 agacggttta agcggaagca tcttactgcc attgactgcc agcatttggc tcggagtcac 180 ttggctgtga cccagccctt cggtcaaaga tggacaaaca gagatccgaa ccatggtctc 240 tatcctaaac cgagaacaaa aagagggagt aggggtcagg gaagtcaaag atgcatccct 300 gagttcttcc tagcaggcaa gcagccgtgc accaatgaca tggccaaaag caattctgtt 360 ggccaggaca gctgtcagga ctctgagggt gacatgatct ttcctgcaga gagcagctgt 420 gcactgcctc aggagggcag tgcagggccg ggctcaccag ggtctgcccc gccctccagg 480 aagcggtctt ggtcctctga ggaagagagt aaccaggcta ccgggaccag ccggtgggat 540 ggagtttcta agaaagctcc acggcaccat ttgtctgtgc catgcacaag gcctagggag 600 gccaggcaag aagcagagga cagtacgtct cggctctctg cggagtctgg tgaaaccgac 660 caagatgctg gggacgtggg tcctgatccc attcctgact catactatgg gcttcttggg 720 accttgccct gccaggaagc actgagccac atttgcagcc tgcctagtga ggtcctgagg 780 cacgtgtttg ccttcctccc ggtggaagac ctctatcgga acctgagctt ggtgtgccac 840 ttgtggaggg agatcatcag tgacccgctg ttcattcctt ggaagaagct gtaccatcga 900 tacctgatga atgaagagca agctgtcagc aaagtggacg gcatcctgtc taactgtggc 960 atagaaaagg agtcagacct gtgtgtgctg aacctcatac gatacacagc caccactaag 1020 tgctctccga gtgtggatcc cgagagggtg ctgtggagtc tgagggacca ccccctcctc 1080 cccgaggctg aggcgtgtgt gcggcaacac ctccccgacc tctacgctgc tgccgggggt 1140 gtcaacatct gggccctggt ggcggctgtg gtgctcctct ccagcagtgt gaatgacatc 1200 cagcgactgc tcttctgcct ccggagaccc agctccacgg tgaccatgcc agatgtcacc 1260 gagaccctgt actgcatagc cgtgcttctc tacgccatga gggagaaggg gattaacatc 1320 agcaatagga ttcactacaa cattttctat tgcctatatc ttcaggagaa ttcctgcact 1380 caggccacaa aagttaaaga ggagccatct gtctggccag gcaagaaaac catccaactt 1440 acacatgaac aacagctgat tctgaatcac aagatggaac ctctccaggt ggtgaaaatt 1500 atggcctttg ccggcactgg gaagacctca acgctggtca agtatgcaga gaagtggtct 1560 cagagcaggt ttctgtatgt gacattcaac aagagcatcg caaagcaggc cgaacgcgtc 1620 ttccccagca acgtcatctg caaaaccttc cactccatgg cctacgggca catagggcgg 1680 aagtaccagt caaagaagaa gttgaatctc ttcaagttaa cacccttcat ggtcaactcc 1740 gtccttgctg aagggaaggg tggattcata agagccaagc ttgtgtgtaa gactctagaa 1800 aacttctttg cctcggctga cgaagagctg accattgatc acgtgcctat ttggtgtaag 1860 aacagccaag gacagagagt catggttgag cagagtgaaa aactgaatgg tgtccttgaa 1920 gcgagccgcc tctgggataa catgcggaag ctgggggagt gcacagaaga ggcgcaccag 1980 atgactcatg acggctactt gaaactctgg cagctgagca agccttcgct ggcctctttt 2040 gacgccatct ttgtggatga ggcccaggac tgcacaccag ctatcatgaa catagttctg 2100 tctcagccat gtgggaaaat ctttgtaggg gacccgcacc agcagatcta taccttccgg 2160 ggtgcggtca acgccctgtt cacagtgccc cacacccacg tcttctatct cacgcagagt 2220 tttcggtttg gtgtggaaat agcttatgtg ggagctacta tcttggatgt ttgcaagaga 2280 gtcaggaaaa agactttggt tggaggaaac catcagagtg gcattagagg tgacgcaaag 2340 gggcaagtgg ccttgttgtc ccggaccaac gccaacgtgt ttgatgaggc cgtacgggtg 2400 acggaagggg aattcccttc aaggatacat ttgattgggg ggattaaatc atttggattg 2460 gacagaatca ttgatatttg gatccttctt cagccagagg aagaacggag gaaacaaaac 2520 ctcgtcatta aagacaaatt tatcagaaga tgggtgcaca aagaaggctt tagtggcttc 2580 aagaggtatg tgaccgctgc cgaggacaag gagcttgaag ccaagatcgc agttgttgaa 2640 aagtatagca tcaggattcc agagctggtg caaaggatag aaaaatgcca tatagaagat 2700 ttggactttg cagagtacat tctgggcact gtgcacaaag ccaaaggcct ggagtttgac 2760 actgtgcatg ttttggatga ttttgtgaaa gtgccttgtg cccggcataa cctgccccag 2820 cttccgcact tcagagttga gtcattttct gaggatgaat ggaatttact gtatgttgca 2880 gtaactcgag ccaagaagcg tctcatcatg actaaatcat tggaaaacat tttgactttg 2940 gctggggagt acttcttgca agcagagctg acaagcaacg tcttaaaaac aggcgtggtg 3000 cgctgctgcg tgggacagtg caacaatgcc atccctgttg acaccgtcct taccatgaag 3060 aagctgccca tcacctatag caacaggaag gaaaacaagg ggggctacct ctgccactcc 3120 tgtgcggagc agcgcatcgg gcccctggcg ttcctgacag cctccccgga gcaggtgcgc 3180 gccatggagc gcactgtgga gaacatcgta ctgccccggc atgaggccct gctcttcctc 3240 gtcttctgag gacaaggcgc acgttctccg cagtgcagag cagcttgccg aggaccccgc 3300 gtgaagaaag ccagcgaggg gggcttctgc tccctgagac tctgggttca cccacagcac 3360 tttctgagga agaggacacc agcccaagct ggacctgcca tttctccact ccctacagac 3420 agccagtctc cacttgcctc ccctctggat gtatctggtc agggaagtgg gggatgttct 3480 tttgataaaa aaaaaaaaaa attttatgta tttaaacttt tattacaaga tttcaattaa 3540 acaggcacca tagcactggc 3560 <210> 335 <211> 3534 <212> DNA <213> Homo sapiens <400> 335 gagctcgctg ccgggggacg ctgggctgag cggccggcgg cgcgggcccg gcggcggcgg 60 cagcggggtc cgggtccgga gcgccacatg agacggttta agcggaagca tcttactgcc 120 attgactgcc agcatttggc tcggagtcac ttggctgtga cccagccctt cggtcaaaga 180 tggacaaaca gagatccgaa ccatggtctc tatcctaaac cgagaacaaa aagagggagt 240 aggggtcagg gaagtcaaag atgcatccct gagttcttcc tagcaggcaa gcagccgtgc 300 accaatgaca tggccaaaag caattctgtt ggccaggaca gctgtcagga ctctgagggt 360 gacatgatct ttcctgcaga gagcagctgt gcactgcctc aggaaggcag tgcagggccg 420 ggctcaccag ggtctgcccc gccctccagg aagcggtctt ggtcctctga ggaagagagt 480 aaccaggcta ccgggaccag ccggtgggat ggagtttcta agaaagctcc acggcaccat 540 ttgtctgtgc catgcacaag gcctagggag gccaggcaag aagcagagga cagtacgtct 600 cggctctctg cggagtctgg tgaaaccgac caagatgctg gggacgtggg tcctgatccc 660 attcctgact catactatgg gcttcttggg accttgccct gccaggaagc actgagccac 720 atttgcagcc tgcctagtga ggtcctgagg cacgtgtttg ccttcctccc ggtggaagac 780 ctctattgga acctgagctt ggtgtgccac ttgtggaggg agatcatcag tgacccgctg 840 ttcattcctt ggaagaagct gtaccatcga tacctgatga atgaagagca agctgtcagc 900 aaagtggacg gcatcctgtc taactgtggc atagaaaagg agtcagacct gtgtgtgctg 960 aacctcatac gatacacagc caccactaag tgctctccga gtgtggatcc cgagagggtg 1020 ctgtggagtc tgagggacca ccccctcctc cccgaggctg aggcgtgtgt gcggcaacac 1080 ctccccgacc tctacgctgc cgggggtgtc aacatctggg ccctggtggc ggctgtggtg 1140 ctcctctcca gcagtgtgaa tgacatccag cgactgctct tctgcctccg gagacccagc 1200 tccacggtga ccatgccaga tgtcaccgag accctgtact gcatagccgt gcttctctac 1260 gccatgaggg agaaggggat taacatcagc aataggattc actacaacat tttctattgc 1320 ctatatcttc aggagaattc ctgcactcag gccacaaaag ttaaagagga gccatctgtc 1380 tggccaggca agaaaaccat ccaacttaca catgaacaac agctgattct gaatcacaag 1440 atggaacctc tccaggtggt gaaaattatg gcctttgccg gcactgggaa gacctcaacg 1500 ctggtcaagt atgcagagaa gtggtctcag agcaggtttc tgtatgtgac attcaacaag 1560 agcatcgcaa agcaggccga acgcgtcttc cccagcaacg tcatctgcaa aaccttccac 1620 tccatggcct acgggcacat agggcggaag taccagtcaa agaagaagtt gaatctcttc 1680 aagttaacac ccttcatggt caactccgtc cttgctgaag ggaagggtgg attcataaga 1740 gccaagcttg tgtgtaagac tctagaaaac ttctttgcct cggctgacga agagctgacc 1800 attgatcacg tgcctatttg gtgtaagaac agccaaggac agagagtcat ggttgagcag 1860 agtgaaaaac tgaatggtgt ccttgaagcg agccgcctct gggataacat gcggaagctg 1920 ggggagtgca cagaagaggc gcaccagatg actcatgacg gctacttgaa actctggcag 1980 ctgagcaagc cttcgctggc ctcttttgac gccatctttg tggatgaggc ccaggactgc 2040 acaccagcta tcatgaacat agttctgtct cagccatgtg ggaaaatctt tgtaggggac 2100 ccgcaccagc agatctatac cttccggggt gcggtcaacg ccctgttcac agtgccccac 2160 acccacgtct tctatctcac gcagagtttt cggtttggtg tggaaatagc ttatgtggga 2220 gctactatct tggatgtttg caagagagtc aggaaaaaga ctttggttgg aggaaaccat 2280 cagagtggca ttagaggtga cgcaaagggg caagtggcct tgttgtcccg gaccaacgcc 2340 aacgtgtttg atgaggccgt acgggtgacg gaaggggaat tcccttcaag gatacatttg 2400 attgggggga ttaaatcatt tggattggac agaatcattg atatttggat ccttcttcag 2460 ccagaggaag aacggaggaa acaaaacctc gtcattaaag acaaatttat cagaagatgg 2520 gtgcacaaag aaggctttag tggcttcaag aggtatgtga ccgctgccga ggacaaggag 2580 cttgaagcca agatcgcagt tgttgaaaag tataacatca ggattccaga gctggtgcaa 2640 aggatagaaa aatgccatat agaagatttg gactttgcag agtacattct gggcactgtg 2700 cacaaagcca aaggcctgga gtttgacact gtgcatgttt tggatgattt tgtgaaagtg 2760 ccttgtgccc ggcataacct gccccagctt ccgcacttca gagttgagtc attttctgag 2820 gatgaatgga atttactgta tgttgcagta actcgagcca agaagcgtct catcatgacc 2880 aaatcattgg aaaacatttt gactttggct ggggagtact tcttgcaagc agagctgaca 2940 agcaacgtct taaaaacagg cgtggtgcgc tgctgcgtgg gacagtgcaa caatgccatc 3000 cctgttgaca ccgtccttac catgaagaag ctgctcatca cctatagcaa caggaaggaa 3060 aacaaggggg gctacctctg ccactcctgt gcggagcagc gcatcgggcc cctggcgttc 3120 ctgacagcct ccccggagca ggtgcgcgcc atggagcgca ctgtggagaa catcgtactg 3180 ccccggcatg aggccctgct cttcctcgtc ttctgaggac aaggcgcacg ttctccgcag 3240 tgcagagcag cttgccgagg accccgcgtg aagaaagcca gcgagggggg cttctgctcc 3300 ctgagactct gggttcaccc acagcacttt ctgaggaaga ggacaccagc ccaagctgga 3360 cctgccattt ctccactccc tacagacagc cagtctccac ttgcctcccc tctggatgta 3420 tctggtcagg gaagtggggg atgttctttt gataaaaaaa aaaaaaaatt ttatgtattt 3480 aaacttttat tacaagattt caattaaaca ggcaccatag ctctggcaaa aaaa 3534 <210> 336 <211> 3102 <212> DNA <213> Homo sapiens <400> 336 ccccgccctc caggaagcgg tcttggtcct ctgaggaaga gagtaaccag gctaccggga 60 ccagccggtg ggatggagtt tctaagaaag ctccacggca ccatttgtct gtgccatgca 120 caaggcctag ggaggccagg caagaagcag aggacagtac gtctcggctc tctgcggagt 180 ctggtgaaac cgaccaagat gctggggacg tgggtcctga tcccattcct gactcatact 240 atgggcttct tgggaccttg ccctgccagg aagcactgag ccacatttgc agcctgccta 300 gtgaggtcct gaggcacgtg tttgccttcc tcccggtgga agacctctat tggaacctga 360 gcttggtgtg ccacttgtgg agggagatca tcagtgaccc gctgttcatt ccttggaaga 420 agctgtacca tcgatacctg atgaatgaag agcaagctgt cagcaaagtg gacggcatcc 480 tgtctaactg tggcatagaa aaggagtcag acctgtgtgt gctgaacctc atacgataca 540 cagccaccac taagtgctct ccgagtgtgg atcccgagag ggtgctgtgg agtctgaggg 600 accaccccct cctccccgag gctgaggcgt gtgtgcggca acacctcccc gacctctacg 660 ctgctgccgg gggtgtcaac atctgggccc tggtggcggc tgtggtgctc ctctccagca 720 gtgtgaatga catccagcga ctgctcttct gcctccggag acccagctcc acggtgacca 780 tgccagatgt caccgagacc ctgtactgca tagccgtgct tctctacgcc atgagggaga 840 aggggattaa catcagcaat aggattcact acaacatttt ctattgccta tatcttcagg 900 agaattcctg cactcaggcc acaaaagtta aagaggagcc atctgtctgg ccaggcaaga 960 aaaccatcca acttacacat gaacaacagc tgattctgaa tcacaagatg gaacctctcc 1020 aggtggtgaa aattatggcc tttgccggca ctgggaagac ctcaacgctg gtcaagtatg 1080 cagagaagtg gtctcagagc aggtttctgt atgtgacatt caacaagagc atcgcaaagc 1140 aggccgaacg cgtcttcccc agcaacgtca tctgcaaaac cttccactcc atggcctacg 1200 ggcacatagg gcggaagtac cagtcaaaga agaagttgaa tctcttcaag ttaacaccct 1260 tcatggtcaa ctccgtcctt gctgaaggga agggtggatt cataagagcc aagcttgtgt 1320 gtaagactct agaaaacttc tttgcctcgg ctgacgaaga gctgaccatt gatcacgtgc 1380 ctatttggtg taagaacagc caaggacaga gagtcatggt tgagcagagt gaaaaactga 1440 atggtgtcct tgaagcgagc cgcctctggg ataacatgcg gaagctgggg gagtgcacag 1500 aagaggcgca ccagatgact catgacggct acttgaaact ctggcagctg agcaagcctt 1560 cgctggcctc ttttgacgcc atctttgtgg atgaggccca ggactgcaca ccagctatca 1620 tgaacatagt tctgtctcag ccatgtggga aaatctttgt aggggacccg caccagcaga 1680 tctatacctt ccggggtgcg gtcaacgccc tgttcacagt gccccacacc cacgtcttct 1740 atctcacgca gagttttcgg tttggtgtgg aaatagctta tgtgggagct actatcttgg 1800 atgtttgcaa gagagtcagg aaaaagactt tggttggagg aaaccatcag agtggcatta 1860 gaggtgacgc aaaggggcaa gtggccttgt tgtcccggac caacgccaac gtgtttgatg 1920 aggccgtacg ggtgacggaa ggggaattcc cttcaaggat acatttgatt ggggggatta 1980 aatcatttgg attggacaga atcattgata tttggatcct tcttcagcca gaggaagaac 2040 ggaggaaaca aaacctcgtc attaaagaca aatttatcag aagatgggtg cacaaagaag 2100 gctttagtgg cttcaagagg tatgtgaccg ctgccgagga caaggagctt gaagccaaga 2160 tcgcagttgt tgaaaagtat aacatcagga ttccagagct ggtgcaaagg atagaaaaat 2220 gccatataga agatttggac tttgcagagt acattctggg cactgtgcac aaagccaaag 2280 gcctggagtt tgacactgtg catgttttgg atgattttgt gaaagtgcct tgtgcccggc 2340 ataacctgcc ccagcttccg cacttcagag ttgagtcatt ttctgaggat gaattgaatt 2400 tactgtatgt tgcagtaact cgagccaaga agcgtctcat catgaccaaa tcattggaaa 2460 acattttgac tttggctggg gagtacttct tgcaagcaga gctgacaagc aacgtcttaa 2520 aaacaggcgt ggtgcgctgc tgcgtgggac agtgcaacaa tgccatccct gttgacaccg 2580 tccttaccat gaagaagctg cccatcacct atagcaacag gaaggaaaac aaggggggct 2640 acctctgcca ctcctgtgcg gagcagcgca tcgggcccct ggcgttcctg acagcctccc 2700 cggagcaggt gcgcgccatg gagcgcactg tggagaacat cgtactgccc cggcatgagg 2760 ccctgctctt cctcgtcttc tgaggacaag gcgcacgttc tccgcagtgc agagcagctt 2820 gccgaggacc ccgcgtgaag aaagccagcg aggggggctt ctgctccctg agactctggg 2880 ttcacccaca gcactttctg aggaagagga caccagccca agctggacct gccatttctc 2940 cactccctac agacagccag tctccacttg cctcccctct ggatgtatct ggtcagggaa 3000 gtgggggatg ttcttttgat aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 3060 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa 3102 <210> 337 <211> 3098 <212> DNA <213> Homo sapiens <400> 337 ccacgcgtcc ggtgggatgg agtttctaag aaagctccac ggcaccattt gtctgtgcca 60 tgcacaaggc ctagggaggc caggcaagaa gcagaggaca gtacgtctcg gctctctgcg 120 gagtctggtg aaaccgacca agatgctggg gacgtgggtc ctgatcccat tcctgactca 180 tactatgggc ttcttgggac cttgccctgc caggaagcac tgagccacat ttgcagcctg 240 cctagtgagg tcctgaggca cgtgtttgcc ttcctcccgg tggaagacct ctattggaac 300 ctgagcttgg tgtgccactt gtggagggag atcatcagtg acccgctgtt cattccttgg 360 aagaagctgt accatcgata cctgatgaat gaagagcaag ctgtcagcaa agtggacggc 420 atcctgtcta actgtggcat agaaaaggag tcagacctgt gtgtgctgaa cctcatacga 480 tacacagcca ccactaagtg ctctccgagt gtggatcccg agagggtgct gtggagtctg 540 agggaccacc ccctcctccc cgaggctgag gcgtgtgtgc ggcaacacct ccccgacctc 600 tacgctgctg ccgggggtgt caacatctgg gccctggtgg cggctgtggt gctcctctcc 660 agcagtgtga atgacatcca gcgactgctc ttctgcctcc ggagacccag ctccacggtg 720 accatgccag atgtcaccga gaccctgtac tgcatagccg tgcttctcta cgccatgagg 780 gagaagggga ttaacatcag caataggatt cactacaaca ttttctattg cctatatctt 840 caggagaatt cctgcactca ggccacaaaa gttaaagagg agccatctgt ctggccaggc 900 aagaaaacca tccaacttac acatgaacaa cagctgattc tgaatcacaa gatggaacct 960 ctccaggtgg tgaaaattat ggcctttgcc ggcactggga agacctcaac gctggtcaag 1020 tatgcagaga agtggtctca gagcaggttt ctgtatgtga cattcaacaa gagcatcgca 1080 aagcaggccg aacgcgtctt ccccagcaac gtcatctgca aaaccttcca ctccatggcc 1140 tacgggcaca tagggcggaa gtaccagtca aagaagaagt tgaatctctt caagttaaca 1200 cccttcatgg tcaactccgt ccttgctgaa gggaagggtg gattcataag agccaagctt 1260 gtgtgtaaga ctctagaaaa cttctttgcc tcggctgacg aagagctgac cattgatcac 1320 gtgcctattt ggtgtaagaa cagccaagga cagagagtca tggttgagca gagtgaaaaa 1380 ctgaatggtg tccttgaagc gagccgcctc tgggataaca tgcggaagct gggggagtgc 1440 acagaagagg cgcaccagat gactcatgac ggctacttga aactctggca gctgagcaag 1500 ccttcgctgg cctcttttga cgccatcttt gtggatgagg cccaggactg cacaccagct 1560 atcatgaaca tagttctgtc tcagccatgt gggaaaatct ttgtagggga cccgcaccag 1620 cagatctata ccttccgggg tgcggtcaac gccctgttca cagtgcccca cacccacgtc 1680 ttctatctca cgcagagttt tcggtttggt gtggaaatag cttatgtggg agctactatc 1740 ttggatgttt gcaagagagt caggaaaaag actttggttg gaggaaacca tcagagtggc 1800 attagaggtg acgcaaaggg gcaagtggcc ttgttgtccc ggaccaacgc caacgtgttt 1860 gatgaggccg tacgggtgac ggaaggggaa ttcccttcaa ggatacattt gattgggggg 1920 attaaatcat ttggattgga cagaatcatt gatatttgga tccttcttca gccagaggaa 1980 gaacggagga aacaaaacct cgtcattaaa gacaaattta tcagaagatg ggtgcacaaa 2040 gaaggcttta gtggcttcaa gaggtatgtg accgctgccg aggacaagga gcttgaagcc 2100 aagatcgcag ttgttgaaaa gtataacatc aggattccag agctggtgca aaggatagaa 2160 aaatgccata tagaagattt ggactttgca gagtacattc tgggcactgt gcacaaagcc 2220 aaaggcctgg agtttgacac tgtgcatgtt ttggatgatt ttgtgaaagt gccttgtgcc 2280 cggcataacc tgccccagct tccgcacttc agagttgagt cattttctga ggatgaatgg 2340 aatttactgt atgttgcagt aactcgagcc aagaagcgtc tcatcatgac caaatcattg 2400 gaaaacattt tgactttggc tggggagtac ttcttgcaag cagagctgac aagcaacgtc 2460 ttaaaaacag gcgtggtgcg ctgctgcgtg ggacagtgca acaatgccat ccctgttgac 2520 accgtcctta ccatgaagaa gctgcccatc acctatagca acaggaagga aaacaagggg 2580 ggctacctct gccactcctg tgcggagcag cgcatcgggc ccctggcgtt cctgacagcc 2640 tccccggagc aggtgcgcgc catggagcgc actgtggaga acatcgtact gccccggcat 2700 gaggccctgc tcttcctcgt cttctgagga caaggcgcac gttctccgca gtgcagagca 2760 gcttgccgag gaccccgcgt gaagaaagcc agcgaggggg gcttctgctc cctgagactc 2820 tgggttcacc cacagcactt tctgaggaag aggacaccag cccaagctgg acctgccatt 2880 tctccactcc ctacagacag ccagtctcca cttgcctccc ctctggatgt atctggtcag 2940 ggaagtgggg gatgttcttt tgataaaaaa aaaaaaaatt ttatgtattt aaacttttat 3000 tacaagattt caattaaaca ggcaccatag cactggcaaa aaaaaaaaaa aaaaaaaaaa 3060 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa 3098 <210> 338 <211> 3656 <212> DNA <213> Homo sapiens <400> 338 acagccccgg cctgccccgc gtgggagaag ccgcggttcc gggcacgggg cggtttttcc 60 tcagggacgg agcggtccgg gatgagcacg gaggggcctg gggatccgag agcgctggcg 120 tccgccgtcc tggagctgca gcggcccgta cgtgattcgg gactgaacac tgagacggtt 180 taagcggaag catcttactg ccattgactg ccagcatttg gctcggagtc acttggctgt 240 gacccagccc ttcggtcaaa gatggacaaa cagagatccg aaccatggtc tctatcctaa 300 accgagaaca aaaagaggga gtaggggtca gggaagtcaa agatgcatcc ctgagttctt 360 cctagcaggc aagcagccgt gcaccaatga catggccaaa agcaattctg ttggccagga 420 cagctgtcag gactctgagg gtgacatgat ctttcctgcg gagagcagct gtgcactgcc 480 tcaggaaggc agtgcagggc cgggctcacc agggtctgcc ccgccctcca ggaagcggtc 540 ttggtcctct gaggaagaga gtaaccaggc taccgggacc agccggtggg atggagtttc 600 taagaaagct ccacggcacc atttgtctgt gccatgcaca aggcctaggg aggccaggca 660 agaagcagag gacagtacgt ctcggctctc tgcggagtct ggtgaaaccg accaagatgc 720 tggggacgtg ggtcctgatc ccattcctga ctcatactat gggcttcttg ggaccttgcc 780 ctgccaggaa gcactgagcc acatttgcag cctgcctagt gaggtcctga ggcacgtgtt 840 tgccttcctc ccggtggaag acctctattg gaacctgagc ttggtgtgcc acttgtggag 900 ggagatcatc agtgacccgc tgttcattcc ttggaagaag ctgtaccatc gatacctgat 960 gaatgaagag caagctgtca gcaaagtgga cggcatcctg tctaactgtg gcatagaaaa 1020 ggagtcagac ctgtgtgtgc tgaacctcat acgatacaca gccaccacta agtgctctcc 1080 gagtgtggat cccgagaggg tgctgtggag tctgagggac caccccctcc tccccgaggc 1140 tgaggcgtgt gtgcggcaac acctccccga cctctacgct gctgccgggg gtgtcaacat 1200 ctgggccctg gtggcggctg tggtgctcct ctccagcagt gtgaatgaca tccagcgact 1260 gctcttctgc ctccggagac ccagctccac ggtgaccatg ccagatgtca ccgagaccct 1320 gtactgcata gccgtgcttc tctacgccat gagggagaag gggattaaca tcagcaatag 1380 gattcactac aacattttct attgcctata tcttcaggag aattcctgca ctcaggccac 1440 aaaagttaaa gaggagccat ctgtctggcc aggcaagaaa accatccaac ttacacatga 1500 acaacagctg attctgaatc acaagatgga acctctccag gtggtgaaaa ttatggcctt 1560 tgccggcact gggaagacct caacgctggt caagtatgca tagaagtggt ctcagagcag 1620 gtttctgcat gtgacattca acaagagcat cgcgaagcag gccgaacgcg tcttccccag 1680 caacgtcatc tgcaaaacct tccactccat ggcctacggg cacatagggc ggaagtacca 1740 gtcaaagaag aagttgaatc tcttcaagtt aacacccttc atggtcaact ccgtccttgc 1800 tgaagggaag ggtggattca taagagccaa gcttgtgtgt aagactctag aaaacttctt 1860 tgcctcggct gacgaagagc tgaccattga tcacgtgcct atttggtgta agaacagcca 1920 aggacagaga gtcatggttg agcagagtga aaaactgaat ggtgtccttg aagcgagccg 1980 cctctgggat aacatgcgga agctggggga gtgcacagaa gaggcgcacc agatgactca 2040 tgacggctac ttgaaactct ggcagctgag caagccttcg ctggcctctt ttgacgccat 2100 ctttgtggat gaggcccagg actgcacacc agctatcatg aacatagttc tgtctcagcc 2160 atgtgggaaa atctttgtag gggacccgca ccagcagatc tataccttcc ggggtgcggt 2220 caacgccctg ttcacagtgc cccacaccca cgtcttctat ctcacgcaga gttttcggtt 2280 tggtgtggaa atagcttatg tgggagctac tatcttggat gtttgcaaga gagtcaggaa 2340 aaagactttg gttggaggaa accatcagag tggcattaga ggtgacgcaa aggggcaagt 2400 ggccttgttg tcccggacca acgccaacgt gtttgatgag gccgtacggg tgacggaagg 2460 ggaattccct tcaaggatac atttgattgg ggggattaaa tcatttggat tggacagaat 2520 cattgatatt tggatccttc ttcagccaga ggaagaacgg aggaaacaaa acctcgtcat 2580 taaagacaaa tttatcagaa gatgggtgca caaagaaggc tttagtggct tcaagaggta 2640 tgtgaccgct gccgaggaca aggagcttga agccaagatc gcagttgttg aaaagtataa 2700 catcaggatt ccagagctgg tgcaaaggat agaaaaatgc catatagaag atttggactt 2760 tgcagagatg gagtctcacc atgttggcca ggctggtctc gaactcccaa cctcagagta 2820 cattctgggc actgtgcaca aagccaaagg cctggagttt gacactgtgc atgttttgga 2880 tgattttgtg aaagtgcctt gtgcccggca taacctgccc cagcttccgc acttcagagt 2940 tgagtcattt tctgaggatg aatggaattt actgtatgtt gcagtaactc gagccaagaa 3000 gcgtctcatc atgaccaaat cattggaaaa cattttgact ttggctgggg agtacttctt 3060 gcaagcagag ctgacaagca acgtcttaaa aacaggcgtg gtgcgctgct gcgtgggaca 3120 gtgcaacaat gccatccctg ttgacaccgt ccttaccatg aagaagctgc ccatcaccta 3180 tagcaacagg aaggaaaaca aggggggcta cctctgccac tcctgtgcgg agcagcgcat 3240 cgggcccctg gcgttcctga cagcctcccc ggagcaggtg cgcgccatgg agcgcactgt 3300 ggagaacatc gtactgcccc ggcatgaggc cctgctcttc ctcgtcttct gaggacaagg 3360 cgcacgttct ccgcagtgca gagcagcttg ccgaggaccc cgcgtgaaga aagccagcga 3420 ggggggcttc tgctccctga gactctgggt tcacccacag cactttctga ggaagaggac 3480 accagcccaa gctggacctg ccatttctcc actccctaca gacagccagt ctccacttgc 3540 ctcccctctg gatgtatctg gtcagggaag tgggggatgt tcttttgata aaaaaaaaaa 3600 aaattttatg tatttaaact tttattacaa gatttcaatt aaacaggcac catagc 3656 <210> 339 <211> 2669 <212> DNA <213> Homo sapiens <400> 339 ctgtaccatc gatacctgat gaatgaagag caagctgtca gcaaagtgga cggcatcctg 60 tctaactgtg gcatagaaaa ggagtcagac ctgtgtgtgc tgaacctcat acgatacaca 120 gccaccacta agtgctctcc gagtgtggat cccgagaggg tgctgtggag tctgagggac 180 caccccctcc tccccgaggc tgaggcgtgt gtgcggcaac acctccccga cctctacgct 240 gccgggggtg tcaacatctg ggccctggtg gcggctgtgg tgctcctctc cagcagtgtg 300 aatgacatcc agcgactgct cttctgcctc cggagaccca gctccacggt gaccatgcca 360 gatgtcaccg agaccctgta ctgcatagcc gtgcttctct acgccatgag ggagaagggg 420 attaacatca gcaataggat tcactacaac attttctatt gcctatatct tcaggagaat 480 tcctgcactc aggccacaaa agttaaagag gagccatctg tctggccagg caagaaaacc 540 atccaactta cacatgaaca acagctgatt ctgaatcaca agatggaacc tctccaggtg 600 gtgaaaatta tggcctttgc cggcactggg aagacctcaa cgctggtcaa gtatgcagag 660 aagtggtctc agagcaggtt tctgtatgtg acattcaaca agagcatcgc aaagcaggcc 720 gaacgcgtct tccccagcaa cgtcatctgc aaaaccttcc actccatggc ctacgggcac 780 atagggcgga agtaccagtc aaagaagaag ttgaatctct tcaagttaac acccttcatg 840 gtcaactccg tccttgctga agggaagggt ggattcataa gagccaagct tgtgtgtaag 900 actctagaaa acttctttgc ctcggctgac gaagagctga ccattgatca cgtgcctatt 960 tggtgtaaga acagccaagg acagagagtc atggttgagc agagtgaaaa actgaatggt 1020 gtccttgaag cgagccgcct ctgggataac atgcggaagc tgggggagtg cacagaagag 1080 gcgcaccaga tgactcatga cggctacttg aaactctggc agctgagcaa gccttcgctg 1140 gcctcttttg acgccatctt tgtggatgag gcccaggact gcacaccagc tatcatgaac 1200 atagttctgt ctcagccatg tgggaaaatc tttgtagggg acccgcacca gcagatctat 1260 accttccggg gtgcggtcaa cgccctgttc acagtgcccc acacccacgt cttctatctc 1320 acgcagagtt ttcggtttgg tgtggaaata gcttatgtgg gagctactat cttggatgtt 1380 tgcaagagag tcaggaaaaa gactttggtt ggaggaaacc atcagagtgg cattagaggt 1440 gacgcaaagg ggcaagtggc cttgttgtcc cggaccaacg ccaacgtgtt tgatgaggcc 1500 gtacgggtga cggaagggga attcccttca aggatacatt tgattggggg gattaaatca 1560 tttggattgg acagaatcat tgatatttgg atccttcttc agccagagga agaacggagg 1620 aaacaaaacc tcgtcattaa agacaaattt atcagaagat gggtgcacaa agaaggcttt 1680 agtggcttca agaggtatgt gaccgctgcc gaggacaagg agcttgaagc caagatcgca 1740 gttgttgaaa agtataacat caggattcca gagctggtgc aaaggataga aaaatgccat 1800 atagaagatt tggactttgc agagtacatt ctgggcactg tgcacaaagc caaaggcctg 1860 gagtttgaca ctgtgcatgt tttggatgat tttgtgaaag tgccttgtgc ccggcataac 1920 ctgccccagc ttccgcactt cagagttgag tcattttctg aggatgaatg gaatttactg 1980 tatgttgcag taactcgagc caagaagcgt ctcatcatga ccaaatcatt ggaaaacatt 2040 ttgactttgg ctggggagta cttcttgcaa gcagagctga caagcaacgt cttaaaaaca 2100 ggcgtggtgc gctgctgcgt gggacagtgc aacaatgcca tccctgttga caccgtcctt 2160 accatgaaga agctgctcat cacctatagc aacaggaagg aaaacaaggg gggctacctc 2220 tgccactcct gtgcggagca gcgcatcggg cccctggcgt tcctgacagc ctccccggag 2280 caggtgcgcg ccatggagcg cactgtggag aacatcgtac tgccccggca tgaggccctg 2340 ctcttcctcg tcttctgagg acaaggcgca cgttctccgc agtgcagagc agcttgccga 2400 ggaccccgcg tgaagaaagc cagcgagggg ggcttctgct ccctgagact ctgggttcac 2460 ccacagcact ttctgaggaa gaggacacca gcccaagctg gacctgccat ttctccactc 2520 cctacagaca gccagtctcc acttgcctcc cctctggatg tatctggtca gggaagtggg 2580 ggatgttctt ttgataaaaa aaaaaaaaaa ttttatgtat ttaaactttt attacaagat 2640 ttcaattaaa caggcaccat agcactggc 2669 <210> 340 <211> 1632 <212> DNA <213> Homo sapiens <400> 340 tgtaagaaca gccaaggaca gagagtcatg gttgagcaga gtgaaaaact gaatggtgtc 60 cttgaagcga gccgcctctg ggataacatg cggaagctgg gggagtgcac agaagaggcg 120 caccagatga ctcatgacgg ctacttgaaa ctctggcagc tgagcaagcc ttcgctggcc 180 tcttttgacg ccatctttgt ggatgaggcc caggactgca caccagctat catgaacata 240 gttctgtctc agccatgtgg gaaaatcttt gtaggggacc cgcaccagca gatctatacc 300 ttccggggtg cggtcaacgc cctgttcaca gtgccccaca cccacgtctt ctatctcacg 360 cagagttttc ggtttggtgt ggaaatagct tatgtgggag ctactatctt ggatgtttgc 420 aagagagtca ggaaaaagac tttggttgga ggaaaccatc agagtggcat tagaggtgac 480 gcaaaggggc aagtggcctt gttgtcccgg accaacgcca acgtgtttga tgaggccgta 540 cgggtgacgg aaggggaatt cccttcaagg atacatttga ttggggggat taaatcattt 600 ggattggaca gaatcattga tatttggatc cttcttcagc cagaggaaga acggaggaaa 660 caaaacctcg tcattaaaga caaatttatc agaagatggg tgcacaaaga aggctttagt 720 ggcttcaaga ggtatgtgac cgctgccgag gacaaggagc ttgaagccaa gatcgcagtt 780 gttgaaaagt ataacatcag gattccagag ctggtgcaaa ggatagaaaa atgccatata 840 gaagatttgg actttgcaga gtacattctg ggcactgtgc acaaagccaa aggcctggag 900 tttgacactg tgcatgtttt ggatgatttt gtgaaagtgc cttgtgcccg gcataacctg 960 ccccagcttc cgcacttcag agttgagtca ttttctgagg atgaatggaa tttactgtat 1020 gttgcagtaa ctcgagccaa gaagcgtctc atcatgacca aatcattgga aaacattttg 1080 actttggctg gggagtactt cttgcaagca gagctgacaa gcaacgtctt aaaaacaggc 1140 gtggtgcgct gctgcgtggg acagtgcaac aatgccatcc ctgttgacac cgtccttacc 1200 atgaagaagc tgcccatcac ctatagcaac aggaaggaaa acaagggggg ctacctctgc 1260 cactcctgtg cggagcagcg catcgggccc ctggcgttcc tgacagcctc cccggagcag 1320 gtgcgcgcca tggagcgcac tgtggagaac atcgtactgc cccggcatga ggccctgctc 1380 ttcctcgtct tctgaggaca aggcgcacgt tctccgcagt gcagagcagc ttgccgagga 1440 ccccgcgtga agaaagccag cgaggggggc ttctgctccc tgagactctg ggttcaccca 1500 cagcactttc tgaggaagag gacaccagcc caagctggac ctgccatttc tccactccct 1560 acagacagcc agtctccact tgcctcccct ctggatgtat ctggtcaggg aagtggggga 1620 tgttcttttg at 1632 <210> 341 <211> 1209 <212> DNA <213> Homo sapiens <400> 341 gtcaaagatg catccctgag ttcttcctag caggcaagca gccgtgcacc aatgacatgg 60 ccaaaagcaa ttctgttggc caggacagct gtcaggactc tgagggtgac atgatctttc 120 ctgcagagag cagctgtgca ctgcctcagg aaggcagtgc agggccgggc tcaccagggt 180 ctgccccgcc ctccaggaag cggtcttggt cctctgagga agagagtaac caggctaccg 240 ggaccagccg gtgggatgga gtttctaaga aagctccacg gcaccatttg tctgtgccat 300 gcacaaggcc tagggaggcc aggcaagaag cagaggacag tacgtctcgg ctctctgcgg 360 agtctggtga aaccgaccaa gatgctgggg acgtgggtcc tgatcccatt cctgactcat 420 actatgggct tcttgggacc ttgccctgcc aggaagcact gagccacatt tgcagcctgc 480 ctagtgaggt cctgaggcac gtgtttgcct tcctcccggt ggaagacctc tattggaacc 540 tgagcttggt gtgccacttg tggagggaga tcatcagtga cccgctgttc attccttgga 600 agaagctgta ccatcgatac ctgatgaatg aagagcaagc tgtcagcaaa gtggacggca 660 tcctgtctaa ctgtggcata gaaaaggagt cagacctgtg tgtgctgaac ctcatacgat 720 acacagccac cactaagtgc tctccgagtg tggatcccga gagggtgctg tggagtctga 780 gggaccaccc cctcctcccc gaggctgagg cgtgtgtgcg gcaacacctc cccgacctct 840 acgctgctgc cgggggtgtc aacatctggg ccctggtggc ggctgtggtg ctcctctcca 900 gcagtgtgaa tgacatccag cgactgctct tctgcctccg gagacccagc tccacggtga 960 ccatgccaga tgtcaccgag accctgtact gcatagccgt gcttctctac gccatgaggg 1020 agaaggggat taacatcagc aataggattc actacaacat tttctattgc ctatatcttc 1080 aggagaattc ctgcactcag gccacaaaag ttaaagagga gccatctgtc tggccaggca 1140 agaaaaccat ccaacttaca catgaactaa caaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1200 aaaaaaaaa 1209 <210> 342 <211> 1359 <212> DNA <213> Homo sapiens <400> 342 ggcacgaggg tggaaatagc ttatgtggga gctactatct tggatgtttg caagagagtc 60 aggaaaaaga ctttggttgg aggaaaccat cagagtggca ttagaggtga cgcaaagggg 120 caagtggcct tgttgtcccg gaccaacgcc aacgtgtttg atgaggccgt acgggtgacg 180 gaaggggaat tcccttcaag gatacatttg attgggggga ttaaatcatt tggattggac 240 agaatcattg atatttggat ccttcttcag ccagaggaag aacggaggaa acaaaacctc 300 gtcattaaag acaaatttat cagaagatgg gtgcacaaag aaggctttag tggcttcaag 360 aggtatgtga ccgctgccga ggacaaggag cttgaagcca agatcgcagt tgttgaaaag 420 tataacatca ggattccaga gctggtgcaa aggatagaaa aatgccatat agaagatttg 480 gactttgcag agtacattct gggcactgtg cacaaagcca aaggcctgga gtttgacact 540 gtgcatgttt tggatgattt tgtgaaagtg ccttgtgccc ggcataacct gccccagctt 600 ccgcacttca gagttgagtc attttctgag gatgaatgga atttactgta tgttgcagta 660 actcgagcca agaagcgtct catcatgacc aaatcattgg aaaacatttt gactttggct 720 ggggagtact tcttgcaagc agagctgaca agcaacgtct taaaaacagg cgtggtgcgc 780 tgctgcgtgg gacagtgcaa caatgccatc cctgttgaca ccgtccttac catgaagaag 840 ctgcccatca cctatagcaa caggaaggaa aacaaggggg gctacctctg ccactcctgt 900 gcggagcagc gcatcgggcc cctggcgttc ctgacagcct ccccggagca ggtgcgcgcc 960 atggagcgca ctgtggagaa catcgtactg ccccggcatg aggccctgct cttcctcgtc 1020 ttctgaggac aaggcgcacg ttctccgcag tgcagagcag cttgccgagg accccgcgtg 1080 aagaaagcca gcgagggggg cttctgctcc ctgagactct gggttcaccc acagcacttt 1140 ctgaggaaga ggacaccagc ccaagctgga cctgccattt ctccactccc tacagacagc 1200 cagtctccac ttgcctcccc tctggatgta tctggtcagg gaagtggggg atgttctttt 1260 gataaaaaaa aaaaaaaatt ttatgtattt aaacttttat tacaagattt caattaaaca 1320 ggcaccatag cactggcaaa aaaaaaaaaa aaaaaaaaa 1359 <210> 343 <211> 1201 <212> DNA <213> Homo sapiens <400> 343 cggaagggga attcccttca aggatacatt tgattggggg gattaaatca tttggattgg 60 acagaatcat tgatatttgg atccttcttc agccagagga agaacggagg aaacaaaacc 120 tcgtcattaa agacaaattt atcagaagat gggtgcacaa agaaggcttt agtggcttca 180 agaggtatgt gaccgctgcc gaggacaagg agcttgaagc caagatcgca gttgttgaaa 240 agtataacat caggattcca gagctggtgc aaaggataga aaaatgccat atagaagatt 300 tggactttgc agagtacatt ctgggcactg tgcacaaagc caaaggcctg gagtttgaca 360 ctgtgcatgt tttggatgat tttgtgaaag tgccttgtgc ccggcataac ctgccccagc 420 ttccgcactt cagagttgag tcattttctg aggatgaatg gaatttactg tatgttgcag 480 taactcgagc caagaagcgt ctcatcatga ccaaatcatt ggaaaacatt ttgactttgg 540 ctggggagta cttcttgcaa gcagagctga caagcaacgt cttaaaaaca ggcgtggtgc 600 gctgctgcgt gggacagtgc aacaatgcca tccctgttga caccgtcctt accatgaaga 660 agctgcccat cacctatagc aacaggaagg aaaacaaggg gggctacctc tgccactcct 720 gtgcggagca gcgcatcggg cccctggcgt tcctgacagc ctccccggag caggtgcgcg 780 ccatggagcg cactgtggag aacatcgtac tgccccggca tgaggccctg ctcttcctcg 840 tcttctgagg acaaggcgca cgttctccgc agtgcagagc agcttgccga ggaccccgcg 900 tgaagaaagc cagcgagggg ggcttctgct ccctgagact ctgggttcac ccacagcact 960 ttctgaggaa gaggacacca gcccaagctg gacctgccat ttctccactc cctacagaca 1020 gccagtctcc acttgcctcc cctctggatg tatctggtca gggaagtggg ggatgttctt 1080 ttgataaaaa aaaaaaaaaa ttttatgtat ttaaactttt attacaagat ttcaattaaa 1140 caggcaccat agcaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1200 a 1201 <210> 344 <211> 3347 <212> DNA <213> Homo sapiens <400> 344 cggacgcgtg ggcccgccct ccaggaagcg gtcttggtcc tctgaggaag agagtaacca 60 ggctaccggg accagccggt gggatggagt ttctaagaaa gctccacggc accatttgtc 120 tgtgccatgc acaaggccta gggaggccag gcaagaagca gaggacagta cgtctcggct 180 ctctgcggag tctggtgaaa ccgaccaaga tgctggggac gtgggtcctg atcccattcc 240 tgactcatac tatgggcttc ttgggacctt gccctgccag gaagcactga gccacatttg 300 cagcctgcct agtgaggtcc tgaggcacgt gtttgccttc ctcccggtgg aagacctcta 360 ttggaacctg agcttggtgt gccacttgtg gagggagatc atcagtgacc cgctggtgag 420 tgagtgctgg agtcgggaga tgtttcctct aaaagcatgt aactttgctt aatgcacgct 480 tataatcaga ggatcttttc agaaatggtt tccatttgcc ttcagaagac attcagactc 540 cttagaggca tttaaggcct tccgtgtctg ccccacccta tgactctagc ctctttgttc 600 acttccactc aacacagctt ccctgagttc tgtctacagc tcatctgctg tgccctgacc 660 acagactgca cattccttcc cctccctggg ttgctctcat cctcccacct tccccacctg 720 gagggttcct catatctccc ttgacttctt tttttttttt tttgagacag agtttcccac 780 tgttgcccag gctggagtgc agtggcacga tcctgactca ctgcaacctc tgcctcccag 840 gttcaagtga ttctcctgcc tcagcctccc cagtagctgg gattacaggc gtgcgccacc 900 acacccggct aatttttgta ttttcagtag acatggggtt ttaccatgtt ggccaggatg 960 gtctctgaaa ctcctaactt caagtgatct gcctgccatc agcctcccaa gtgctggggt 1020 tacaggcgtg agccaccatg tctggcccgt tttttgtttg tttgtttgtt tgagtgtaag 1080 catttatagc aataaacccc tctcttaaaa cagcccaaca gcattcattg catttcataa 1140 gttttggtat gttatgtttt cattttcatt tgtctcaaga tattttctac ttttctttgt 1200 gatttcttct ttgacccatt ggttgtttta agaatgtgtt ttttgttgtt ggtttttttt 1260 tttttttttg agacagagtc ttgctctgtc acccaggctg gagtgcagtg gctcgacttt 1320 ggctcactgc aacctccacc tcccaagttc aagtgattct tgtgccttag cctcccaagt 1380 agctgggatt acagacatgt gccaccatgc ctggctaatt tttgtatttt taggagagat 1440 agggtttcac catgtaatcc aggatggtct caaagtcctg gccttaagtg atccgcctgt 1500 ctcagctgcc caaagtgcag ggattacagg cataaaccac tgtgcctggg caagggtatg 1560 ttgtttaata tccatatatt tgtggatttt tcagttttcc ttctgctatt gatttctggt 1620 tacattccat tgtgatttaa aaagatactt catataataa cttaagtggt ttttaagttt 1680 gttgaaactt gttttgtggc ctaacaggtg atctatcctg gagaatgttt catgtgccct 1740 tgagaggaat gtatattttg ctgttgttgg gtggagtatt ctgtatatgt tcgttcagcc 1800 cacttagtcc atagtgttgt tcagatcctc tgttttcctt atttatcttc tgtctggttg 1860 ttccatccat cattgaaata gcagtgttga aatctccttc tattattgtg ttgctgttgg 1920 tttctacctt cagttctgtc aggggttgtt tcctatattt aggagctcta atgtgtggtg 1980 catatatatt tatagttatt atatcttctt ggtgaattga cccttttatc attatgtcct 2040 tcgtctctta taacagtatt taacagacag aattgactta aagtctgttt tgtctgatat 2100 tagtatagcc acagctctca tattattttg ttcccattga aaccctgagt tacgtgtact 2160 aatgtttcag acagggaaac tgaagctata gtttttccca gattctttaa ctataacaag 2220 ttagtgttag aaccaagacc aagacccagt tctcctagtt tccaacaaaa atttgtgtaa 2280 catttctgcc tgattttcct ggcttttgaa ttgtgagctg tgattgcttt tcactggtaa 2340 aaggttatct atgtgtttgt ggcttaatct gctttttttc tttctttttt tttttttgag 2400 atggagtctc actctgtcac ccaggctagc gtgcactgca gtggcttgat ctcggctcac 2460 tgcaacctcc gcctcccagg ttcaagtgat tctcctgcct cagcttcctg agtagctggg 2520 actacaggca tgtgccatca tgcctggcta atttttgtat tttttttcag tagagacggg 2580 gcttcgccat gttggccatg ctagtctcaa actcctgacc tcaggcgatc tgcccgcctc 2640 attaatctgc tttctaatgg ccctttgcct catgttattt tgtttgtttt ttaactgcat 2700 agttcattcc ttggaagaag ctgtaccatc gatacctgat gaatgaagag caagctgtca 2760 gcaaagtgga cggcatcctg tctaactgtg gcatagaaaa ggagtcagac ctgtgtgtgc 2820 tgaacctcat acggtgagct ttgcctgtgc tgtaaagaag gcgtctttga agtcttcctt 2880 gtacatcagt gcttatggtc accctactca tggcctctcc tgtgaatgtc ttacagatac 2940 acagccacca ctaagtgctc tccgagtgtg gatcccgaga gggtgctgtg gagtctgagg 3000 gaccaccccc tcctccccga ggctgaggcg tgtgtgcggc aacacctccc cgacctctac 3060 gctgctgccg gggtaggtct ggaggctgcg ggagaaggcg gcatgttatt tcactggagg 3120 aaagtgtact ggtgattcag ttcaattgag gatgacttta tatttatttt taatgtctgt 3180 atttaatctc tgaatgcttt gaagcattca tgttgtcatt gtccccagtg gagaaataaa 3240 aggccatata attgtaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 3300 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa 3347 <210> 345 <211> 1390 <212> DNA <213> Homo sapiens <400> 345 gggaagtgct gttggagccg ctgtggttgc tgtccgcgga gtggaagcgc gtgcttttgt 60 ttgtgtccct ggccatggcg ctgcagctct cccgggagca gggaatcacc ctgcgcggga 120 gcgccgaaat cgtggccgag ttcttctcat tcggcatcaa cagcatttta tatcagcgtg 180 gcatatatcc atctgaaacc tttactcgag tgcagaaata cggactcacc ttgcttgtaa 240 ctactgatct tgagctcata aaatacctaa ataatgtggt ggaacaactg aaagattggt 300 tatacaagtg ttcagttcag aaactggttg tagttatctc aaatattgaa agtggtgagg 360 tcctggaaag atggcagttt gatattgagt gtgacaagac tgcaaaagat gacagtgcac 420 ccagagaaaa gtctcagaaa gctatccagg atgaaatccg ttcagtgatc agacagatca 480 cagctacggt gacatttctg ccactgttgg aagtttcttg ttcatttgat ctgctgattt 540 atacagacaa agatttggtt gtacctgaaa aatgggaaga gtcgggacca cagtttatta 600 ccaattctga ggaagtccgc cttcgttcat ttactactac aatccacaaa gtaaatagca 660 tggtggccta caaaattcct gtcaatgact gaggatgaca tgaggaaaat aatgtaattg 720 taattttgaa atgtggtttt cctgaaatca ggtcatctat agttgatatg ttttatttca 780 ttggttaatt tttacatgga gaaaaccaaa atgatactta ctgaactgtg tgtaattgtt 840 cctttatttt tttggtacct atttgactta ccatggagtt aacatcatga atttattgca 900 cattgttcaa aaggaaccag gaggtttttt tgtcaacatt gtgatgtata ttcctttgaa 960 gatagtaact gtagatggaa aaacttgtgc tataaagcta gatgctttcc taaatcagat 1020 gttttggtca agtagtttga ctcagtatag gtagggagat atttaagtat aaaatacaac 1080 aaaggaagtc taaatattca gaatctttgt taaggtcctg aaagtaactc ataatctata 1140 aacaatgaaa tattgctgta tagctccttt tgaccttcat ttcatgtata gttttcccta 1200 ttgaatcagt ttccaattat ttgactttaa tttatgtaac ttgaacctat gaagcaatgg 1260 atatttgtac tgtttaatgt tctgtgatac agaactctta aaaatgtttt ttcatgtgtt 1320 ttataaaatc aagttttaag tgaaagtgag gaaataaagt taagtttgtt ttaaaaaaaa 1380 aaaaaaaaaa 1390 <210> 346 <211> 1403 <212> DNA <213> Homo sapiens <400> 346 gggaagtgct gttggagccg ctgtggttgc tgtccgcgga gtggaagcgc gtgcttttgt 60 ttgtgtccct ggccatggcg ctgcagctct cccgggagca gggaatcacc ctgcgcggga 120 gcgccgaaat cgtggccgag ttcttctcat tcggcatcaa cagcatttta tatcagcgtg 180 gcatatatcc atctgaaacc tttactcgag tgcagaaata cggactcacc ttgcttgtaa 240 ctactgatct tgagctcata aaatacctaa ataatgtggt ggaacaactg aaagattggt 300 tatacaagtg ttcagttcag aaactggttg tagttatctc aaatattgaa agtggtgagg 360 tcctggaaag atggcagttt gatattgagt gtgacaagac tgcaaaagat gacagtgcac 420 ccagagaaaa gtctcagaaa gctatccagg atgaaatccg ttcagtgatc agacagatca 480 cagctacggt gacatttctg ccactgttgg aagtttcttg ttcatttgat ctgctgattt 540 atacagacaa agatttggtt gtacctgaaa aatgggaaga gtcgggacca cagtttatta 600 ccaattctga ggaagtccgc cttcgttcat ttactactac aatccacaaa gtaaatagca 660 tggtggccta caaaattcct gtcaatgact gaggatgaca tgaggaaaat aatgtaattg 720 taattttgaa atgtggtttt cctgaaatca ggtcatctat agttgatatg ttttatttca 780 ttggttaatt tttacatgga gaaaaccaaa atgatactta ctgaactgtg tgtaattgtt 840 ccttttattt ttttggtacc tatttgactt accatggagt taacatcatg aatttattgc 900 acattgttca aaaggaacca ggaggttttt ttgtcaacat tgtgatgtat attcctttga 960 agatagtaac tgtagatgga aaaacttgtg ctataaagct agatgctttc ctaaatcaga 1020 tgttttggtc aagtagtttg actcagtata ggtagggaga tatttaagta taaaatacaa 1080 caaaggaagt ctaaatattc agaatctttg ttaaggtcct gaaagtaact cataatctat 1140 aaacaatgaa atattgctgt atagctcctt ttgaccttca tttcatgtat agttttccct 1200 attgaatcag tttccaatta tttgacttta atttatgtaa cttgaaccta tgaagcaatg 1260 gatatttgta ctgtttaatg ttctgtgata cagaactctt aaaaatgttt tttcatgtgt 1320 tttataaaat caagttttaa gtgaaagtga ggaaataaag ttaagtttgt tttaaatttg 1380 tcttaaaaaa aaaaaaaaaa aaa 1403 <210> 347 <211> 1391 <212> DNA <213> Homo sapiens <400> 347 gctgttggag ccgctgtggt tgctgtccgc ggagtggaag cgcgtgcttt tgtttgtgtc 60 cctggccatg gcgctgcagc tctcccggga gcagggaatc accctgcgcg ggagcgccga 120 aatcgtggcc gagttcttct cattcggcat caacagcatt ttatatcagc gtggcatata 180 tccatctgaa acctttactc gagtgcagaa atacggactc accttgcttg taactactga 240 tcttgagctc ataaaatacc taaataatgt ggtggaacaa ctgaaagatt ggttatacaa 300 gtgttcagtt cagaaactgg ttgtagttat ctcaaatatt gaaagtggtg aggtcctgga 360 aagatggcag tttgatattg agtgtgacaa gactgcaaaa gatgacagtg cacccagaga 420 aaagtctcag aaagctatcc aggatgaaat ccgttcagtg atcagacaga tcacagctac 480 ggtgacattt ctgccactgt tggaagtttc ttgttcattt gatctgctga tttatacaga 540 caaagatttg gttgtacctg aaaaatggga agagtcggga ccacagttta ttaccaattc 600 tgaggaagtc cgccttcgtt catttactac tacaatccac aaagtaaata gcatggtggc 660 ctacaaaatt cctgtcaatg actgaggatg acatgaggaa aataatgtaa ttgtaatttt 720 gaaatgtggt tttcctgaaa tcaggtcatc tatagttgat atgttttatt tcattggtta 780 atttttacat ggagaaaacc aaaatgatac ttactgaact gtgtgtaatt gttcctttta 840 tttttttggt acctatttga cttaccatgg agttaacatc atgaatttat tgcacattgt 900 tcaaaaggaa ccaggaggtt tttttgtcaa cattgtgatg tatattcctt tgaagatagt 960 aactgtagat ggaaaaactt gtgctataaa gctagatgct ttcctaaatc agatgttttg 1020 gtcaagtagt ttgactcagt ataggtaggg agatatttaa gtataaaata caacaaagga 1080 agtctaaata ttcagaatct ttgttaaggt cctgaaagta actcataatc tataaacaat 1140 gaaatattgc tgtatagctc cttttgacct tcatttcatg tatagttttc cctattgaat 1200 cagtttccaa ttatttgact ttaatttatg taacttgaac ctatgaagca atggatattt 1260 gtactgttta atgttctgtg atacagaact cttaaaaatg ttttttcatg tgttttataa 1320 aatcaagttt taagtgaaag tgaggaaata aagttaagtt tgttttagaa aaaaaaaaaa 1380 aaaaaaaaaa a 1391 <210> 348 <211> 1390 <212> DNA <213> Homo sapiens <400> 348 gggaagtgct gttggagccg ctgtggttgc tgtccgcgga gtggaagcgc gtgcttttgt 60 ttgtgtccct ggccatggcg ctgcagctct cccgggagca gggaatcacc ctgcgcggga 120 gcgccgaaat cgtggccgag ttcttctcat tcggcatcaa cagcatttta tatcagcgtg 180 gcatatatcc atctgaaacc tttactcgag tgcagaaata cggactcacc ttgcttgtaa 240 ctactgatct tgagctcata aaatacctaa ataatgtggt ggaacaactg aaagattggt 300 tatacaagtg ttcagttcag aaactggttg tagttatctc aaatattgaa agtggtgagg 360 tcctggaaag atggcagttt gatattgagt gtgacaagac tgcaaaagat gacagtgcac 420 ccagagaaaa gtctcagaaa gctatccagg atgaaatccg ttcagtgatc agacagatca 480 cagctacggt gacatttctg ccactgttgg aagtttcttg ttcatttgat ctgctgattt 540 atacagacaa agatttggtt gtacctgaaa aatgggaaga gtcgggacca cagtttatta 600 ccaattctga ggaagtccgc cttcgttcat ttactactac aatccacaaa gtaaatagca 660 tggtggccta caaaattcct gtcaatgact gaggatgaca tgaggaaaat aatgtaattg 720 taattttgaa atgtggtttt cctgaaatca ggtcatctat agttgatatg ttttatttca 780 ttggttaatt tttacatgga gaaaaccaaa atgatactta ctgaactgtg tgtaattgtt 840 cctttatttt tttggtacct atttgactta ccatggagtt aacatcatga atttattgca 900 cattgttcaa aaggaaccag gaggtttttt tgtcaacatt gtgatgtata ttcctttgaa 960 gatagtaact gtagatggaa aaacttgtgc tataaagcta gatgctttcc taaatcagat 1020 gttttggtca agtagtttga ctcagtatag gtagggagat atttaagtat aaaatacaac 1080 aaaggaagtc taaatattca gaatctttgt taaggtcctg aaagtaactc ataatctata 1140 aacaatgaaa tattgctgta tagctccttt tgaccttcat ttcatgtata gttttcccta 1200 ttgaatcagt ttccaattat ttgactttaa tttatgtaac ttgaacctat gaagcaatgg 1260 atatttgtac tgtttaatgt tctgtgatac agaactctta aaaatgtttt ttcatgtgtt 1320 ttataaaatc aagttttaag tgaaagtgag gaaataaagt taagtttgtt ttaaaaaaaa 1380 aaaaaaaaaa 1390 <210> 349 <211> 1379 <212> DNA <213> Homo sapiens <400> 349 ctgttggagc cgctgtggtt gctgtccgcg gagtggaagc gcgtgctttt gtttgtgtcc 60 ctggccatgg cgctgcagct ctcccgggag cagggaatca ccctgcgcgg gagcgccgaa 120 atcgtggccg agttcttctc attcggcatc aacagcattt tatatcagcg tggcatatat 180 ccatctgaaa cctttactcg agtgcagaaa tacggactca ccttgcttgt aactactgat 240 cttgagctca taaaatacct aaataatgtg gtggaacaac tgaaagattg gttatacaag 300 tgttcagttc agaaactggt tgtagttatc tcaaatattg aaagtggtga ggtcctggaa 360 agatggcagt ttgatattga gtgtgacaag actgcaaaag atgacagtgc acccagagaa 420 aagtctcaga aagctatcca ggatgaaatc cgttcagtga tcagacagat cacagctacg 480 gtgacatttc tgccactgtt ggaagtttct tgttcatttg atctgctgat ttatacagac 540 aaagatttgg ttgtacctga aaaatgggaa gagtcgggac cacagtttat taccaattct 600 gaggaagtcc gccttcgttc atttactact acaatccaca aagtaaatag catggtggcc 660 tacaaaattc ctgtcaatga ctgaggatga catgaggaaa ataatgtaat tgtaattttg 720 aaatgtggtt ttcctgaaat caagtcatct atagttgata tgttttattt cattggttaa 780 tttttacatg gagaaaacca aaatgatact tactgaactg tgtgtaattg ttcctttatt 840 tttttggtac ctatttgact taccatggag ttaacatcat gaatttattg cacattgttc 900 aaaaggaacc aggaggtttt tttgtcaaca ttgtgatgta tattcctttg aagatagtaa 960 ctgtagatgg aaaaacttgt gctataaagc tagatgcttt cctaaatcag atgttttggt 1020 caagtagttt gactcagtat aggtagggag atatttaagt ataaaataca acaaaggaag 1080 tctaaatatt cagaatcttt gttaaggtcc tgaaagtaac tcataatcta taaacaatga 1140 aatattgctg tatagctcct tttgaccttc atttcatgta tagttttccc tattgaatca 1200 gtttccaatt atttgacttt aatttatgta acttgaacct atgaagcaat ggatatttgt 1260 actgtttaat gttctgtgat acagaactct taaaaatgtt ttttcatgtg ttttataaaa 1320 tcaagtttta agtgaaagtg aggaaataaa gttaagtttg ttttaaattt gtcttaaaa 1379 <210> 350 <211> 1484 <212> DNA <213> Homo sapiens <400> 350 tggaagcgcg tgcttttgtt tgtgtccctg gccatggcgc tgcagctctc ccgggagcag 60 ggaatcaccc tgcgcgggag cgccgaaatc gtggccgagt tcttctcatt cggcatcaac 120 agcattttat atcagcgtgg catatatcca tctgaaacct ttactcgagt gcagaaatac 180 ggactcacct tgcttgtaac tactgatctt gagctcataa aatacctaaa taatgtggtg 240 gaacaactga aagattggtt atacaagtgt tcagttcaga aactggttgt agttatctca 300 aatattgaaa gtggtgaggt cctggaaaga tggcagtttg atattgagtg tgacaagact 360 gcaaaagatg acagtgcacc cagagaaaag tctcagaaag ctatccagga tgaaatccgt 420 tcagtgatca gacagatcac agctacggtg acatttctgc cactgttgga agtttcttgt 480 tcatttgatc tgctgattta tacagacaaa gatttggttg tacctgaaaa atgggaagag 540 tcgggaccac agtttattac caattctgag gaagtgcgcc ttcgttcatt tactactaca 600 atccacaaag taaatagcat ggtggcctac aaaattcctg tcaatgactg aggatgacat 660 gaggaaaata atgtaattgt aattttgaaa tgtggttttc ctgaaatcag gtcatctata 720 gttgatatgt tttatttcat tggttaattt ttacatggag aaaaccaaaa tgatacttac 780 tgaactgtgt gtaattgttc cttttatttt tttggtacct atttgactta ccatggagtt 840 aacatcatga atttattgca cattgttcaa aaggaaccag gaggtttttt tgtcaacatt 900 gtgatgtata ttcctttgaa gatagtaact gtagatggaa aaacttgtgc tataaagcta 960 gatgctttcc taaatcagat gttttggtca agtagtttga ctcagtatag gtagggagat 1020 atttaagtat aaaatacaac aaaggaagtc taaatattca gaatctttgt taaggtcctg 1080 aaagtaactc ataatctata aacaatgaaa tattgctgta tagctccttt tgaccttcat 1140 ttcatgtata gttttcccta ttgaatcagt ttccaattat ttgactttaa tttatgtaac 1200 ttgaacctat gaagcaatgg atatttgtac tgtttaatgt tctgtgatac agaacagatt 1260 aatactccct ttttatcatt acagttagct aaaaaattgc caggcagtcc acaaaacaga 1320 atttgcttta agaccaaccc acagagtcag ctggagacta acggcgctgg ggcctgctgg 1380 gccgggatat agtcgtgttt agctaagtgt cgagagcatt aagaagaaag tcctggttgg 1440 aggcgcaagg cctgcagcac cagctgtgga atccccaata atgt 1484 <210> 351 <211> 1485 <212> DNA <213> Homo sapiens <400> 351 tctttacttt tgaaactctt ggcggggaag tgctgttgga gccgctgtgg ttgctgtccg 60 tgtagtgaaa gcgcgtgcct ttgtttgtgt ccctggccat gtgtccctgg ccatggcgct 120 gcagctctcc cgggagcagg gaatcaccct gcgtgggagt gccgaaatcg tggacgagtt 180 cttctcattc ggcatcaaca gcattttata tcagcgtggc atttatccat ctgaaatctt 240 tactcgagtg cagaaatacg gactcacctt gcttgtaact actgatcttg agctcataaa 300 atacctaaat aatgtggtgg aacaactaaa agattggtta tacaagtgtt cagttcagaa 360 actggttgta gttatctcaa atattgaaag tggtgaggtc ctggaaagat gacagtttga 420 tattgagtgt gataagactg caaaagatga cagtgcaccc agagaaaagt ctcagaaagc 480 tattcaggat gaaatccgtt cagtcatcag acagatcaca gctacagtga catttctgcc 540 actgttggaa gtttcttgtt catttgatct gctgatttac acagacaaag atttggttgt 600 acctgaaaaa tgggaagagt cgggaccaca gtttattacc aattctgagg aagtctgcct 660 ttgttcattt actactacaa tccacaaagt aaatagcatg gtggcctaca aaattcctgt 720 caatgactga agatgacatg aggaaataat gtaattgtaa ttttgaaatg tggttttcct 780 gaaatcaagt catctatagt tgatatgttt tatttcattg gttaatttat acatggagaa 840 aaccaaaatg atacttactg aactgtgtgt aattgttcct tttgtttttt tggtacctat 900 ttgactcacc atggagttaa catcatgaat ttattgtgca ttattcaaaa ggaaccagga 960 ggtttttttt ttgtcaacat tgtgatgtat attcctttga agatagtaac tgtagatgga 1020 aaaacttgtg ctataaagct aagtgctttc ctaaatcaga tgttttggtc aagtagcttg 1080 actcagtata ggtagggaga tatttaatta taaaatacag caaaggaagt ctaaatattc 1140 agaatctttg ttaaagtcct gaaagtaact aataatctat aaacaatgaa atattgctgt 1200 gtagctcctt ttgaccttca tttcatgcat aattttccct atcgaatcag tttccaatta 1260 tttgacttta atttatgtaa cttgaacctg tgaagggatg gatatttgta ctgcttgatg 1320 ttctgtgata cagaactctt aaaaattttt ttttgtgttt tataaaatca agttttaagt 1380 gaggaaataa gtttgttaaa aacaaaaaaa gaagcaagtg gatttgtgtg gtgtaatttg 1440 cctgctcata taatccactc atttttctat agcatcattt attga 1485 <210> 352 <211> 532 <212> DNA <213> Homo sapiens <400> 352 tgtttgtgtc cctggccatg gcgctgcagc tctcccggga gcagggaatc accctgcgcg 60 ggagcgccga aatcgtggcc gagttcttct cattcggcat caacagcatt ttatatcagc 120 gtggcatata tccatctgaa acctttactc gagtgcagaa atacggactc accttgcttg 180 taactactga tcttgagctc ataaaatacc taaataatgt ggtggaacaa ctgaaagtgc 240 acccagagaa aagtctcaga aagctatcca ggatgaaatc cgttcagtga tcagacagat 300 cacagctacg gtgacatttc tgccactgtt ggaagtttct tgttcatttg atctgctgat 360 ttatacagac aaagatttgg ttgtacctga aaaatgggaa gagtcgggac cacagtttat 420 taccaattct gaggaagtcc gccttcgttc atttactact acaatccaca aagtaaatag 480 catggtggcc tacaaaattc ctgtcaatga ctgaggatga catgaggaaa at 532 <210> 353 <211> 721 <212> DNA <213> Homo sapiens <400> 353 ggaaaaccac gtttgaaaat tacactatct tcctcatgtc atcctcggtc attgacaagg 60 ttttgtgggt caccacgctg tgagctgtgt ggatgtagca gcaaatgaat gaagggagac 120 ttgctcggat tggtcatgaa ctgtggtccc cactcttccc atcttccagg tacaaccaga 180 tctttgcata aatcatagat cgaatgaaca agaaaattca acagttgcag aaatgtcact 240 aactgtggtt catctgatcg ctggatggat tttgtcctgg atagctttct gagacttttc 300 tctgggttca gtgtcctcct ttctctgggt tacctgtcct cctttctctg ggtgcgctct 360 ctgttctctg ggtgcaccgt catcttttgc agtcttgtca cactcagtat caaagtgcct 420 tccttcaagg acatcaccac tttcaatatt tgcaatgact gtggcgaatt tatgaacgaa 480 catttgtata gccaatcctt tggttgttcg agcacattat ttaggtattg tatgagcaca 540 ggatctgtag ttacaagcaa gtctacctaa accacctgcc aaggagtcct ggagaagtca 600 cgcacagcag tgcctcagca ggcaggtcca cctacatggt cccagctgtg gatgtgaaaa 660 ttaccctgtg ccttggcacc agcccccctc agctgtggtt gcaggttaat cctgctccta 720 c 721 <210> 354 <211> 3658 <212> DNA <213> Homo sapiens <400> 354 gcccagacaa gcaacatggc tcggaaacgc gcggccggcg gggagccgcg gggacgcgaa 60 ctgcgcagcc agaaatccaa ggccaagagc aaggcccggc gtgaggagga ggaggaggat 120 gcctttgaag atgagaaacc cccaaagaag agccttctct ccaaagtttc acaaggaaag 180 aggaaaagag gctgcagtca tcctgggggt tcagcagatg gtccagcaaa aaagaaagtg 240 gccaaggtga ctgttaaatc tgaaaacctc aaggttataa aggatgaagc cctcagcgat 300 ggggatgacc tcagggactt tccaagtgac ctcaagaagg cacaccatct gaagagaggg 360 gctaccatga atgaagacag caatgaagaa gaggaagaaa gtgaaaatga ttgggaagag 420 gttgaagaac ttagtgagcc tgtgctgggt gacgtgagag aaagtacagc cttctctcga 480 tctcttctgc ctgtgaagcc agtggagata gagattgaaa cgccagagca ggcgaagaca 540 agagaaagaa gtgaaaagat aaaactggag tttgagacat atcttcggag ggcgatgaaa 600 cgtttcaata aaggggtcca tgaggacaca cacaaggttc accttctctg cctgctagca 660 aatggcttct atcgaaataa catctgcagc cagccagatc tgcatgctat tggcctgtcc 720 atcatcccag cccgctttac cagagtgctg cctcgagatg tggacaccta ctacctctca 780 aacctggtga agtggttcat tggaacattt acagttaatg cagaactttc agccagtgaa 840 caagataacc tgcagactac attggaaagg agatttgcta tttactctgc tcgagatgat 900 gaggaattgg tccatatatt cttactgatt ctccgggctc tgcagctctt gacccggctg 960 gtattgtctc tacagccaat tcctctgaag tcagcaacag caaagggaaa gaaaccttcc 1020 aaggaaagat tgactgcgga tccaggaggc tcctcagaaa cttccagcca agttctagaa 1080 aaccacacca aaccaaagac cagcaaagga accaaacaag aggaaacctt tgctaagggc 1140 acctgcaggc caagtgccaa agggaagagg aacaagggag gcagaaagaa acggagcaag 1200 ccctcctcca gcgaggaaga tgagggccca ggagacaagc aggagaaggc aacccagcga 1260 cgtccgcatg gccgggagcg gcgggtggcc tccagggtgt cttataaaga ggagagtggg 1320 agtgatgagg ctggcagcgg ctctgatttt gagctctcca gtggagaagc ctctgatccc 1380 tctgatgagg attccgaacc tggccctcca aagcagagga aagcccccgc tcctcagagg 1440 acaaaggctg ggtccaagag tgcctccagg acccatcgtg ggagccatcg taaggaccca 1500 agcttgccag cggcatcctc aagctcttca agcagtaaaa gaggcaagaa aatgtgcagc 1560 gatggtgaga aggcagaaaa aagaagcata gctggtatag accagtggct agaggtgttc 1620 tgtgagcagg aggaaaagtg ggtatgtgta gactgtgtgc acggtgtggt gggccagcct 1680 ctgacctgtt acaagtacgc caccaagccc atgacctatg tggtgggcat tgacagtgac 1740 ggctgggtcc gagatgtcac acagaggtac gacccagtct ggatgacagt gacccgcaag 1800 tgccgggttg atgctgagtg gtgggccgag accttgagac cataccagag cccatttatg 1860 gacagggaga agaaagaaga cttggagttt caggcaaaac acatggacca gcctttgccc 1920 actgccattg gcttatataa gaaccaccct ctgtatgccc tgaagcggca tctcctgaaa 1980 tatgaggcca tctatcccga gacagctgcc atccttgggt attgtcgtgg agaagcggtc 2040 tactccaggg attgtgtgca cactctgcat tccagagaca cgtggctgaa gaaagcaaga 2100 gtggtgaggc ttggagaagt accctacaag atggtgaaag gcttttctaa ccgtgctcgg 2160 aaagcccgac ttgctgagcc ccagctgcgg gaagaaaatg acctgggcct gtttggctac 2220 tggcagacag aggagtatca gcccccagtg gccgtggacg ggaaggtgcc ccggaacgag 2280 tttgggaatg tgtacctctt cctgcccagc atgatgccta ttggctgtgt ccagctgaac 2340 ctgcccaatc tacaccgcgt ggcccgcaag ctggacatcg actgtgtcca ggccatcact 2400 ggctttgatt tccatggcgg ctactcccat cccgtgactg atggatacat cgtctgcgag 2460 gaattcaaag acgtgctcct gactgcctgg gaaaatgagc aggcagtcat tgaaaggaag 2520 gagaaggaga aaaaggagaa gcgggctcta gggaactgga agttgctggc caaaggtctg 2580 ctcatcaggg agaggctgaa gcgtcgctac gggcccaaga gtgaggcagc agctccccac 2640 acagatgcag gaggtggact ctcttctgat gaagaggagg ggaccagctc tcaagcagaa 2700 gcggccagga tactggctgc ctcctggcct caaaaccgag aagatgaaga aaagcagaag 2760 ctgaagggtg ggcccaagaa gaccaaaagg gaaaagaaag cagcagcttc ccacctgttc 2820 ccatttgaga agctgtgagc tgagcgccca ctagaggggc acccaccagt tgctgctgcc 2880 ccactacagg ccccacacct gccctgggca tgcccagccc ctggtggtgg gggcttctct 2940 gctgagaagg caaactgagg cagcatgcac ggaggcgggg tcaggggaga cgaggccaag 3000 ctgaggaggt gctgcaggtc ccgtctggct ccagcccttg tcagattcac ccagggtgaa 3060 gccttcaaag ctttttgcta ccaaagccca ctcacccttt gagctacaga acactttgct 3120 aggagatact cttctgcctc ctagacctgt tctttccatc tttagaaaca tcagtttttg 3180 tatggaagcc accgggagat ttctggatgg tggtgcatcc gtgaatgcgc tgatcgtttc 3240 ttccagttag agtcttcatc tgtccgacaa gttcactcgc ctcggttgcg gacctaggac 3300 catttctctg caggccactt accttcccct gagtcaggct tactaatgct gccctcactg 3360 cctctttgca gtaggggaga gagcagagaa gtacaggtca tctgctggga tctagttttc 3420 caagtaacat tttgtggtga cagaagccta aaaaaagcta aaatcaggaa agaaaaggaa 3480 aaatacgaat tgaaaattaa ggaaatgtta gtaaaataga tcagtgttaa actagattgt 3540 attcattact agataaaatg tataaagctc tctgtactaa ggagaaatga cttttataac 3600 attttgagaa aataataaag catttatcta aaaaaaaaaa aaaaaaaaaa aaaaaaaa 3658 <210> 355 <211> 3658 <212> DNA <213> Homo sapiens <400> 355 gcccagacaa gcaacatggc tcggaaacgc gcggccggcg gggagccgcg gggacgcgaa 60 ctgcgcagcc agaaatccaa ggccaagagc aaggcccggc gtgaggagga ggaggaggat 120 gcctttgaag atgagaaacc cccaaagaag agccttctct ccaaagtttc acaaggaaag 180 aggaaaagag gctgcagtca tcctgggggt tcagcagatg gtccagcaaa aaagaaagtg 240 gccaaggtga ctgttaaatc tgaaaacctc aaggttataa aggatgaagc cctcagcgat 300 ggggatgacc tcagggactt tccaagtgac ctcaagaagg cacaccatct gaagagaggg 360 gctaccatga atgaagacag caatgaagaa gaggaagaaa gtgaaaatga ttgggaagag 420 gttgaagaac ttagtgagcc tgtgctgggt gacgtgagag aaagtacagc cttctctcga 480 tctcttctgc ctgtgaagcc agtggagata gagattgaaa cgccagagca ggcgaagaca 540 agagaaagaa gtgaaaagat aaaactggag tttgagacat atcttcggag ggcgatgaaa 600 cgtttcaata aaggggtcca tgaggacaca cacaaggttc accttctctg cctgctagca 660 aatggcttct atcgaaataa catctgcagc cagccagatc tgcatgctat tggcctgtcc 720 atcatcccag cccgctttac cagagtgctg cctcgagatg tggacaccta ctacctctca 780 aacctggtga agtggttcat tggaacattt acagttaatg cagaactttc agccagtgaa 840 caagataacc tgcagactac attggaaagg agatttgcta tttactctgc tcgagatgat 900 gaggaattgg tccatatatt cttactgatt ctccgggctc tgcagctctt gacccggctg 960 gtattgtctc tacagccaat tcctctgaag tcagcaacag caaagggaaa gaaaccttcc 1020 aaggaaagat tgactgcgga tccaggaggc tcctcagaaa cttccagcca agttctagaa 1080 aaccacacca aaccaaagac cagcaaagga accaaacaag aggaaacctt tgctaagggc 1140 acctgcaggc caagtgccaa agggaagagg aacaagggag gcagaaagaa acggagcaag 1200 ccctcctcca gcgaggaaga tgagggccca ggagacaagc aggagaaggc aacccagcga 1260 cgtccgcatg gccgggagcg gcgggtggcc tccagggtgt cttataaaga ggagagtggg 1320 agtgatgagg ctggcagcgg ctctgatttt gagctctcca gtggagaagc ctctgatccc 1380 tctgatgagg attccgaacc tggccctcca aagcagagga aagcccccgc tcctcagagg 1440 acaaaggctg ggtccaagag tgcctccagg acccatcgtg ggagccatcg taaggaccca 1500 agcttgccag cggcatcctc aagctcttca agcagtaaaa gaggcaagaa aatgtgcagc 1560 gatggtgaga aggcagaaaa aagaagcata gctggtatag accagtggct agaggtgttc 1620 tgtgagcagg aggaaaagtg ggtatgtgta gactgtgtgc acggtgtggt gggccagcct 1680 ctgacctgtt acaagtacgc caccaagccc atgacctatg tggtgggcat tgacagtgac 1740 ggctgggtcc gagatgtcac acagaggtac gacccagtct ggatgacagt gacccgcaag 1800 tgccgggttg atgctgagtg gtgggccgag accttgagac cataccagag cccatttatg 1860 gacagggaga agaaagaaga cttggagttt caggcaaaac acatggacca gcctttgccc 1920 actgccattg gcttatataa gaaccaccct ctgtatgccc tgaagcggca tctcctgaaa 1980 tatgaggcca tctatcccga gacagctgcc atccttgggt attgtcgtgg agaagcggtc 2040 tactccaggg attgtgtgca cactctgcat tccagagaca cgtggctgaa gaaagcaaga 2100 gtggtgaggc ttggagaagt accctacaag atggtgaaag gcttttctaa ccgtgctcgg 2160 aaagcccgac ttgctgagcc ccagctgcgg gaagaaaatg acctgggcct gtttggctac 2220 tggcagacag aggagtatca gcccccagtg gccgtggacg ggaaggtgcc ccggaacgag 2280 tttgggaatg tgtacctctt cctgcccagc atgatgccta ttggctgtgt ccagctgaac 2340 ctgcccaatc tacaccgcgt ggcccgcaag ctggacatcg actgtgtcca ggccatcact 2400 ggctttgatt tccatggcgg ctactcccat cccgtgactg atggatacat cgtctgcgag 2460 gaattcaaag acgtgctcct gactgcctgg gaaaatgagc aggcagtcat tgaaaggaag 2520 gagaaggaga aaaaggagaa gcgggctcta gggaactgga agttgctggc caaaggtctg 2580 ctcatcaggg agaggctgaa gcgtcgctac gggcccaaga gtgaggcagc agctccccac 2640 acagatgcag gaggtggact ctcttctgat gaagaggagg ggaccagctc tcaagcagaa 2700 gcggccagga tactggctgc ctcctggcct caaaaccgag aagatgaaga aaagcagaag 2760 ctgaagggtg ggcccaagaa gaccaaaagg gaaaagaaag cagcagcttc ccacctgttc 2820 ccatttgaga agctgtgagc tgagcgccca ctagaggggc acccaccagt tgctgctgcc 2880 ccactacagg ccccacacct gccctgggca tgcccagccc ctggtggtgg gggcttctct 2940 gctgagaagg caaactgagg cagcatgcac ggaggcgggg tcaggggaga cgaggccaag 3000 ctgaggaggt gctgcaggtc ccgtctggct ccagcccttg tcagattcac ccagggtgaa 3060 gccttcaaag ctttttgcta ccaaagccca ctcacccttt gagctacaga acactttgct 3120 aggagatact cttctgcctc ctagacctgt tctttccatc tttagaaaca tcagtttttg 3180 tatggaagcc accgggagat ttctggatgg tggtgcatcc gtgaatgcgc tgatcgtttc 3240 ttccagttag agtcttcatc tgtccgacaa gttcactcgc ctcggttgcg gacctaggac 3300 catttctctg caggccactt accttcccct gagtcaggct tactaatgct gccctcactg 3360 cctctttgca gtaggggaga gagcagagaa gtacaggtca tctgctggga tctagttttc 3420 caagtaacat tttgtggtga cagaagccta aaaaaagcta aaatcaggaa agaaaaggaa 3480 aaatacgaat tgaaaattaa ggaaatgtta gtaaaataga tcagtgttaa actagattgt 3540 attcattact agataaaatg tataaagctc tctgtactaa ggagaaatga cttttataac 3600 attttgagaa aataataaag catttatcta aaaaaaaaaa aaaaaaaaaa aaaaaaaa 3658 <210> 356 <211> 3558 <212> DNA <213> Homo sapiens <400> 356 tcgaaggggc gtggccaagc gcaccgcctc ggggcggggc cggcgttcta gcgcatcgcg 60 gccgggtgcg tcactcgcga agtggaattt gcccagacaa gcaacatggc tcggaaacgc 120 gcggccggcg gggagccgcg gggacgcgaa ctgcgcagcc agaaatccaa ggccaagagc 180 aaggcccggc gtgaggagga ggaggaggat gcctttgaag atgagaaacc cccaaagaag 240 agccttctct ccaaagtttc acaaggaaag aggaaaagag gctgcagtca tcctgggggt 300 tcagcagatg gtccagcaaa aaagaaagtg gccaaggtga ctgttaaatc tgaaaacctc 360 aaggttataa aggatgaagc cctcagcgat ggggatgacc tcagggactt tccaagtgac 420 ctcaagaagg cacaccatct gaagagaggg gctaccatga atgaagacag caatgaagaa 480 gaggaagaaa gtgaaaatga ttgggaagag gttgaagaac ttagtgagcc tgtgctgggt 540 gacgtgagag aaagtacagc cttctctcga tctcttctgc ctgtgaagcc agtggagata 600 gagattgaaa cgccagagca ggcgaagaca agagaaagaa gtgaaaagat aaaactggag 660 tttgagacat atcttcggag ggcgatgaaa cgtttcaata aaggggtcca tgaggacaca 720 cacaaggttc accttctctg cctgctagca aatggcttct atcgaaataa catctgcagc 780 cagccagatc tgcatgctat tggcctgtcc atcatcccag cccgctttac cagagtgctg 840 cctcgagatg tggacaccta ctacctctca aacctggtga agtggttcat tggaacattt 900 acagttaatg cagaactttc agccagtgaa caagataacc tgcagactac attggaaagg 960 agatttgcta tttactctgc tcgagatgat gaggaattgg tccatatatt cttactgatt 1020 ctccgggctc tgcagctctt gacccggctg gtattgtctc tacagccaat tcctctgaag 1080 tcagcaacag caaagggaaa gaaaccttcc aaggaaagat tgactgcgga tccaggaggc 1140 tcctcagaaa cttccagcca agttctagaa aaccacacca aaccaaagac cagcaaagga 1200 accaaacaag aggaaacctt tgctaagggc acctgcaggc caagtgccaa agggaagagg 1260 aacaagggag gcagaaagaa acggagcaag ccctcctcca gcgaggaaga tgagggccca 1320 ggagacaagc aggagaaggc aacccagcga cgtccgcatg gccgggagcg gcgggtggcc 1380 tccagggtgt cttataaaga ggagagtggg agtgatgagg ctggcagcgg ctctgatttt 1440 gagctctcca gtggagaagc ctctgatccc tctgatgagg attccgaacc tggccctcca 1500 aagcagagga aagcccccgc tcctcagagg acaaaggctg ggtccaagag tgcctccagg 1560 acccatcgtg ggagccatcg taaggaccca agcttgccag tggcatcctc aagctcttca 1620 agcagtaaaa gaggcaagaa aatgtgcagc gatggtgaga aggcagaaaa aagaagcata 1680 gctggtatag accagtggct agaggtgttc tgtgagcagg aggaaaagtg ggtatgtgta 1740 gactgtgtgc acggtgtggt gggccagcct ctgacctgtt acaagtacgc caccaagccc 1800 atgacctatg tggtgggcat tgacagtgac ggctgggtcc gagatgtcac acagaggtac 1860 gacccagtct ggatgacagt gacccgcaag tgccgggttg atgctgagtg gtgggccgag 1920 accttgagac cataccagag cccatttatg gacagggaga agaaagaaga cttggagttt 1980 caggcaaaac acatggacca gcctttgccc actgccattg gcttatataa gaaccaccct 2040 ctgtatgccc tgaagcggca tctcctgaaa tatgaggcca tctatcccga gacagctgcc 2100 atccttgggt attgtcgtgg agaagcggtc tactccaggg attgtgtgca cactctgcat 2160 tccagggaca cgtggctgaa gaaagcaaga gtggtgaggc ttggagaagt accctacaag 2220 atggtgaaag gcttttctaa ccgtgctcgg aaagcccgac ttgctgagcc ccagctgcgg 2280 gaagaaaatg acctgggcct gtttggctac tggcagacag aggagtatca gcccccagtg 2340 gccgtggacg ggaaggtgcc ccggaacgag tttgggaatg tgtacctctt cctgcccagc 2400 atgatgccta ttggctgtgt ccagctgaac ctgcccaatc tacaccgcgt ggcccgcaag 2460 ctggacatcg actgtgtcca ggccatcact ggctttgatt tccatggcgg ctactcccat 2520 cccgtgactg atggatacat cgtctgcgag gaattcaaag acgtgctcct gactgcctgg 2580 gaaaatgagc aggcagtcat tgaaaggaag gagaaggaga aaaaggagaa gcgggctcta 2640 gggaactgga agttgctggc caaaggtctg ctcatcaggg agaggctgaa gcgtcgctac 2700 gggcccaaga gtgaggcagc agctccccac acagatgcag gaggtggact ctcttctgat 2760 gaagaggagg ggaccagctc tcaagcagaa gcggccagga tactggctgc ctcctggcct 2820 caaaaccgag aagatgaaga aaagcagaag ctgaagggtg ggcccaagaa gaccaaaagg 2880 gaaaagaaag cagcagcttc ccacctgttc ccatttgaga agctgtgagc tgagcgccca 2940 ctagaggggc acccaccagt tgctgctgcc ccactacagg ccccacacct gccctgggca 3000 tgcccagccc ctggtggtgg ggggttctct gctgagaagg caaactgagg cagcatgcac 3060 ggaggcgggg tcaggggaga cgaggccaag ctgaggaggt gctgcaggtc ccgtctggct 3120 ccagcccttg tcagattcac ccagggtgaa gccttcaaag ctttttgcta ccaaagccca 3180 ctcacccttt gagctacaga acactttgct aggagatact cttctgcctc ctagacctgt 3240 tctttccatc tttagaaaca tcagtttttg tatggaagcc accgggagat ttctggatgg 3300 tggtgcatcc gtgaatgcgc tgatcgtttc ttccagttag agtcttcatc tgtccgacaa 3360 gttcactcgc ctcggttgcg gacctaggac catttctctg caggccactt accttcccct 3420 gagtcaggct tactaatgct gccctcactg cctctttgca gtaggggaga gagcagagaa 3480 gtacaggtca tctgctggga tctagttttc caagtaacat tttgtggtga cagaagccta 3540 aaaaaagcta aaatcaga 3558 <210> 357 <211> 3455 <212> DNA <213> Homo sapiens <400> 357 gaaagaggaa aagaggctgc ggtcatcctg ggggttcagc agatggtcca gcaaaaaaga 60 aagtggccaa ggtgactgtt aaatctgaaa acctcaaggt tataaaggat gaagccctca 120 gcgatgggga tgacctcagg gactttccaa gtgacctcaa gaaggcacac catctgaaga 180 gaggggctac catgaatgaa gacagcaatg aagaagagga agaaagtgaa aatgattggg 240 aagaggttga agaacttagt gagcctgtgc tgggtgacgt gagagaaagt acagccttct 300 ctcgatctct tctgcctgtg aagccagtgg agatagagat tgaaacgcca gagcaggcga 360 agacaagaga aagaagtgaa aagataaaac tggagtttga gacatatctt cggagggcga 420 tgaaacgttt caataaaggg gtccatgagg acacacacaa ggttcacctt ctctgcctgc 480 tagcaaatgg cttctatcga aataacatct gcagccagcc agatctgcat gctattggcc 540 tgtccatcat cccagcccgc tttaccagag tgctgcctcg agatgtggac acctactacc 600 tctcaaacct ggtgaagtgg ttcattggaa catttacagt taatgcagaa ctttcagcca 660 gtgaacaaga taacctgcag actacattgg aaaggagatt tgctatttac tctgctcgag 720 atgatgagga attggtccat atattcttac tgattctccg ggctctgcag ctcttgaccc 780 ggctggtatt gtctctacag ccaattcctc tgaagtcagc aacagcaaag ggaaagaaac 840 cttccaagga aagattgact gcggatccag gaggctcctc agaaacttcc agccaagttc 900 tagaaaacca caccaaacca aagaccagca aaggaaccaa acaagaggaa acctttgcta 960 agggcacctg caggccaagt gccaaaggga agaggaacaa gggaggcaga aagaaacgga 1020 gcaagccctc ctccagcgag gaagatgagg gcccaggaga caagcaggag aaggcaaccc 1080 agcgacgtcc gcatggccgg gagcggcggg tggcctccag ggtgtcttat aaagaggaga 1140 gtgggagtga tgaggctggc agcggctctg attttgagct ctccagtgga gaagcctctg 1200 atccctctga tgaggattcc gaacctggcc ctccaaagca gaggaaagcc cccgctcctc 1260 agaggacaaa ggctgggtcc aagagtgcct ccaggaccca tcgtgggagc catcgtaagg 1320 acccaagctt gccagcggca tcctcaagct cttcaagcag taaaagaggc aagaaaatgt 1380 gcagcgatgg tgagaaggca gaaaaaagaa gcatagctgg tatagaccag tggctagagg 1440 tgttctgtga gcaggaggaa aagtgggtat gtgtagactg tgtgcacggt gtggtgggcc 1500 agcctctgac ctgttacaag tacgccacca agcccatgac ctatgtggtg ggcattgaca 1560 gtgacggctg ggtccgagat gtcacacaga ggtacgaccc agtctggatg acagtgaccc 1620 gcaagtgccg ggttgatgct gagtggtggg ccgagacctt gagaccatac cagagcccat 1680 ttatggacag ggagaagaaa gaagacttgg agtttcaggc aaaacacatg gaccagcctt 1740 tgcccactgc cattggctta tataagaacc accctctgta tgccctgaag cggcatctcc 1800 tgaaatatga ggccatctat cccgagacag ctgccatcct tgggtattgt cgtggagaag 1860 cggtctactc cagggattgt gtgcacactc tgcattccag agacacgtgg ctgaagaaag 1920 caagagtggt gaggcttgga gaagtaccct acaagatggt gaaaggcttt tctaaccgtg 1980 ctcggaaagc ccgacttgct gagccccagc tgcgggaaga aaatgacctg ggcctgtttg 2040 gctactggca gacagaggag tatcagcccc cagtggccgt ggacgggaag gtgccccgga 2100 acgagtttgg gaatgtgtac ctcttcctgc ccagcatgat gcctattggc tgtgtccagc 2160 tgaacctgcc caatctacac cgcgtggccc gcaagctgga catcgactgt gtccaggcca 2220 tcactggctt tgatttccat ggcggctact cccatcccgt gactgatgga tacatcgtct 2280 gcgaggaatt caaagacgtg ctcctgactg cctgggaaaa tgagcaggca gtcattgaaa 2340 ggaaggagaa ggagaaaaag gagaagcggg ctctagggaa ctggaagttg ctggccaaag 2400 gtctgctcat cagggagagg ctgaagcgtc gctacgggcc caagagtgag gcagcagctc 2460 cccacacaga tgcaggaggt ggactctctt ctgatgaaga ggaggggacc agctctcaag 2520 cagaagcggc caggatactg gctgcctcct ggcctcaaaa ccgagaagat gaagaaaagc 2580 agaagctgaa gggtgggccc aagaagacca aaagggaaaa gaaagcagca gcttcccacc 2640 tgttcccatt tgagaagctg tgagctgagc gcccactaga ggggcaccca ccagttgctg 2700 ctgccccact acaggcccca cacctgccct gggcatgccc agcccctggt ggtgggggct 2760 tctctgctga gaaggcaaac tgaggcagca tgcacggagg cggggtcagg ggagacgagg 2820 ccaagctgag gaggtgctgc aggtcccgtc tggctccagc ccttgtcaga ttcacccagg 2880 gtgaagcctt caaagctttt tgctaccaaa gcccactcac cctttgagct acagaacact 2940 ttgctaggag atactcttct gcctcctaga cctgttcttt ccatctttag aaacatcagt 3000 ttttgtatgg aagccaccgg gagatttctg gatggtggtg catccgtgaa tgcgctgatc 3060 gtttcttcca gttagagtct tcatctgtcc gacaagttca ctcgcctcgg ttgcggacct 3120 aggaccattt ctctgcaggc cacttacctt cccctgagtc aggcttacta atgctgccct 3180 cactgcctct ttgcagtagg ggagagagca gagaagtaca ggtcatctgc tgggatctag 3240 ttttccaagt aacattttgt ggtgacagaa gcctaaaaaa agctaaaatc aggaaagaaa 3300 aggaaaaata cgaattgaaa attaaggaaa tgttagtaaa atagatcagt gttaaactag 3360 attgtattca ttactagata aaatgtataa agctctctgt actaaggaga aatgactttt 3420 ataacatttt gagaaaataa taaagcattt atcta 3455 <210> 358 <211> 1764 <212> DNA <213> Homo sapiens <400> 358 ggcggcgtga gttgcatgtt gtgtgaggat cccggggccg ccgcgtcgct cgggccccgc 60 catggccgtc accatcacgc tcaaaacgct gcagcagcag accttcaaga tccgcatgga 120 gcctgacgag acggtgaagg tgctaaagga gaagatagaa gctgagaagg gtcgtgatgc 180 cttccccgtg gctggacaga aactcatcta tgccggcaag atcttgagtg acgatgtccc 240 tatcagggac tatcgcatcg atgagaagaa ctttgtggtc gtcatggtga ccaagaccaa 300 agccggccag ggtacctcag cacccccaga ggcctcaccc acagctgccc cagagtcctc 360 tacatccttc ccgcctgccc ccacctcagg catgtcccat cccccacctg ccgccagaga 420 ggacaagagc ccatcagagg aatccgcccc cacgacgtcc ccagagtctg tgtcaggctc 480 tgttccctct tcaggtagca gcgggcgaga ggaagacgcg gcctccacgc tagtgacggg 540 ctctgagtat gagacgatgc tgacggagat catgtccatg ggctatgagc gagagcgggt 600 cgtggccgcc ctgagagcca gctacaacaa cccccaccga gccgtggagt atctgctcac 660 gggaattcct gggagccccg agccggaaca cggttctgtc caggagagcc aggtatcgga 720 gcagccggcc acggaagcag caggagagaa ccccctggag ttcctgcggg accagcccca 780 gttccagaac atgcggcagg tgattcagca gaaccctgcg ctgctgcccg ccctgctcca 840 gcagctgggc caggagaacc ctcagctttt acagcaaatc agccggcacc aggagcagtt 900 catccagatg ctgaacgagc cccctgggga gctggcggac atctcagatg tggaggggga 960 ggtgggcgcc ataggagagg aggccccgca gatgaactac atccaggtga cgccgcagga 1020 gaaagaagct atagagaggt tgaaggccct gggcttccca gagagcctgg tcatccaggc 1080 ctatttcgcg tgtgaaaaaa atgagaactt ggctgccaac ttcctcctga gtcagaactt 1140 tgatgacgag tgatgccagg aagccaggcc accgaagccc ccaccctacc cttattccat 1200 gaaagtttta taaaagaaaa aatatatata tattcatgtt tatttaagaa atggaaaaaa 1260 aaatcaaaaa tcttaaaaaa acaagcaaac agtccagctt cctgtcctcc taaagtggcc 1320 cctgttccca tctcccgggc cagacagctg tccccccgtc ctcctcccca gcccagcctg 1380 ctcagagaag ctggcaggac tgggaggcga cagatgggcc cctcttggcc tctgtcccag 1440 ctctctgcag ccagacggaa aggcggctgc ttgcctctcc atcctccgaa aaacccctga 1500 ggaccccccc ccatcctctt ctaggatgag gggaagctgg agccccaact ttgatcctcc 1560 attggagtgg cccaaatctt tccatctagg gcaagtcctg aaaggcccaa ggccccctcc 1620 ccagtctggc cttggcctcc agcctggaga agggctaaca tcagctcatt gtcaaggcca 1680 cccccacccc agaacagaac cgtgtctctg ataaaggttt tgaagtgaat aaagttttaa 1740 aaactaaaaa aaaaaaaaaa aaaa 1764 <210> 359 <211> 1793 <212> DNA <213> Homo sapiens <400> 359 ccggaagtgg tcggcgcgcg gcgcggcgcg cctgggcgct aagatggcgg cggcgtgagt 60 tgcatgttgt gtgaggatcc cggggccgcc gcgtcgctcg ggccccgcca tggccgtcac 120 catcacgctc aaaacgctgc agcagcagac cttcaagatc cgcatggagc ctgacgagac 180 ggtgaaggtg ctaaaggaga agatagaagc tgagaagggt cgtgatgcct tccccgtggc 240 tggacagaaa ctcatctatg ccggcaagat cttgagtgac gatgtcccta tcagggacta 300 tcgcatcgat gagaagaact ttgtggtcgt catggtgacc aagaccaaag ccggccaggg 360 tacctcagca cccccagagg cctcacccac agctgcccca gagtcctcta catccttccc 420 gcctgccccc acctcaggca tgtcccatcc cccacctgcc gccagagagg acaagagccc 480 atcagaggaa tccgccccca cgacgtcccc agagtctgtg tcaggctctg ttccctcttc 540 aggtagcagc gggcgagagg aagacgcggc ctccacgcta gtgacgggct ctgagtatga 600 gacgatgctg acggagatca tgtccatggg ctatgagcga gagcgggtcg tggccgccct 660 gagagccagc tacaacaacc cccaccgagc cgtggagtat ctgctcacgg gaattcctgg 720 gagccccgag ccggaacacg gttctgtcca ggagagccag gtatcggagc agccggccac 780 ggaagcagca ggagagaacc ccctggagtt cctgcgggac cagccccagt tccagaacat 840 gcggcaggtg attcagcaga accctgcgct gctgcccgcc ctgctccagc agctgggcca 900 ggagaaccct cagcttttac agcaaatcag ccggcaccag gagcagttca tccagatgct 960 gaacgagccc cctggggagc tggcggacat ctcagatgtg gagggggagg tgggcgccat 1020 aggagaggag gccccgcaga tgaactacat ccaggtgacg ccgcaggaga aagaagctat 1080 agagaggttg aaggccctgg gcttcccaga gagcctggtc atccaggcct atttcgcgtg 1140 tgaaaaaaat gagaacttgg ctgccaactt cctcctgagt cagaactttg atgacgagtg 1200 atgccaggaa gccaggccac cgaagccccc accctaccct tattccatga aagttttata 1260 aaagaaaaaa tatatatata ttcatgttta tttaagaaat ggaaaaaaaa atcaaaaatc 1320 ttaaaaaaac aagcaaacag tccagcttcc tgtcctccta aagtggcccc tgttcccatc 1380 tcccgggcca gacagctgtc cccccgtcct cctccccagc ccagcctgct cagagaagct 1440 ggcaggactg ggaggcgaca gatgggcccc tcttggcctc tgtcccagct ctctgcagcc 1500 agacggaaag gcggctgctt gcctctccat cctccgaaaa acccctgagg accccccccc 1560 atcctcttct aggatgaggg gaagctggag ccccaacttt gatcctccat tggagtggcc 1620 caaatctttc catctagggc aagtcctgaa aggcccaagg ccccctcccc agtctggcct 1680 tggcctccag cctggagaag ggctaacatc agctcattgt caaggccacc cccaccccag 1740 aacagaaccg tgtctctgat aaaggttttg aagtgaataa agttttaaaa act 1793 <210> 360 <211> 1719 <212> DNA <213> Homo sapiens <400> 360 gggatcccgg ggccgccgcg tcgctcgggc cccgccatgg ccgtcaccat cacgctcaaa 60 acgctgcagc agcagacctt caagatccgc atggagcctg acgagacggt gaaggtgcta 120 aaggagaaga tagaagctga gaagggtcgt gatgccttcc ccgtggctgg acagaaactc 180 atctatgccg gcaagatctt gagtgacgat gtccctatca gggactatcg catcgatgag 240 aagaactttg tggtcgtcat ggtgaccaag accaaagccg gccagggtac ctcagcaccc 300 ccagaggcct cacccacagc tgccccagag tcctctacat ccttcccgcc tgcccccacc 360 tcaggcatgt cccatccccc acctgccgcc agagaggaca agagcccatc agaggaatcc 420 gcccccacga cgtccccaga gtctgtgtca ggctctgttc cctcttcagg tagcagcggg 480 cgagaggaag acgcggcctc cacgctagtg acgggctctg agtatgagac gatgctgacg 540 gagatcatgt ccatgggcta tgagcgagag cgggtcgtgg ccgccctgag agccagctac 600 aacaaccccc accgagccgt ggagtatctg ctcacgggaa ttcctgggag ccccgagccg 660 gaacacggtt ctgtccagga gagccaggta tcggagcagc cggccacgga agcagcagga 720 gagaaccccc tggagttcct gcgggaccag ccccagttcc agaacatgcg gcaggtgatt 780 cagcagaacc ctgcgctgct gcccgccctg ctccagcagc tgggccagga gaaccctcag 840 cttttacagc aaatcagccg gcaccaggag cagttcatcc agatgctgaa cgagccccct 900 ggggagctgg cggacatctc agatgtggag ggggaggtgg gcgccatagg agaggaggcc 960 ccgcagatga actacatcca ggtgacgccg caggagaaag aagctataga gaggttgaag 1020 gccctgggct tcccagagag cctggtcatc caggcctatt tcgcgtgtga aaaaaatgag 1080 aacttggctg ccaacttcct cctgagtcag aactttgatg acgagtgatg ccaggaagcc 1140 aggccaccga agcccccacc ctacccttat tccatgaaag ttttataaaa gaaaaaatat 1200 atatatattc atgtttattt aagaaatgga aaaaaaaatc aaaaatctta aaaaaacaag 1260 caaacagtcc agcttcctgt cctcctaaag tggcccctgt tcccatctcc cgggccagac 1320 agctgtcccc ccgtcctcct ccccagccca gcctgctcag agaagctggc aggactggga 1380 ggcgacagat gggcccctct tggcctctgt cccagctctc tgcagccaga cggaaaggcg 1440 gctgcttgcc tctccatcct ccgaaaaacc cctgaggacc cccccccatc ctcttctagg 1500 atgaggggaa gctggagccc caactttgat cctccattgg agtggcccaa atctttccat 1560 ctagggcaag tcctgaaagg cccaaggccc cctcccagtc tggccttggc ctccagcctg 1620 gagaagggct aacatcagct cattgtcaag gccaccccca ccccagaaca gaaccgtgtc 1680 tctgataaag gttttgaagt gaataaagtt ttaaaaact 1719 <210> 361 <211> 1064 <212> DNA <213> Homo sapiens <220> <221> misc_feature <222> (487)..(491) <223> "n" means any of A, T, G, and C. <400> 361 gggcggggct acaacaaccc ccaccgagcc gtggagtatc tgctcacggg aattcctggg 60 agccccgagc cggaacacgg ttctgtccag gagagccagg tatcggagca gccggccacg 120 aagcagcagg agagaacccc ctggagttcc tgcgggacca gccccagttc cagaacatac 180 ggcaggtgat tcagcagaac cctgcgctgc tgcccgccct gctccagcag ctgggccagg 240 agaaccctca gcttttacag caaatcagcc ggcaccagga gcagttcatc cagatgctga 300 acgagccccc tgggagcctg gcggacatct cagatgtgga gggggaggtg ggcgccatag 360 gagaggaggc cccgcagatg aactacatcc aggtgacgcc gcagagaaag aagctataga 420 gaggttaagg ccctggcttc ccagagagcc tggtcatcca ggcctatttg tgtgaaaaaa 480 atgagannnn ngctgccaac ttcctcctga gtcagaactt tgatgacgag tgatgccagg 540 aagccaggcc accgaagccc ccaccctacc cttattccat gaaagtttta taaaagaaaa 600 aatatatata tattcatgtt tatttaagaa atggaaaaaa aaatcaaaaa tcttaaaaaa 660 acaagcaaac ggtccagctt cctgtcctcc taaagtggcc cctgttccca tctcccgggc 720 cagacagctg tccccccgtc ctcctcccca gcccagcctg ctcagagaag ctggcaggac 780 tgggaggcga cagatggccc ctcttggcct ctgtcccagc tctctgcagc cagacggaaa 840 ggcggctgct tgcctctcca tcctccgaaa aacccctgag gacccccccc catcctcttc 900 taggatgagg ggaagctgga gccccaactt tgatcctcca ttggagtggc ccaaatcttt 960 ccatctaggg caagtcctga aaggcccaag gccccctccc cagtctgcct tgcctccagg 1020 cctggtcttg ggctaacatc agctcattgt caaggccacc cccc 1064 <210> 362 <211> 131 <212> DNA <213> Homo sapiens <220> <221> misc_feature <222> (17)..(17) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (98)..(98) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (100)..(101) <223> "n" means any of A, T, G, and C. <400> 362 cacagcagca gaccttnaag atccgcatgg agcctgacga gacggtgaag gtgctaaagg 60 agaagataga agctgagaag ggtcgtgatc cttccccntn nctggacaga aactcatcta 120 tcccggcaag a 131 <210> 363 <211> 2084 <212> DNA <213> Homo sapiens <400> 363 cccacgcgtc cgcggacgcg tgggcggacg cgtgggtgcg cggcggcacc atgcaggtca 60 ccctgaagac cctccagcag cagaccttca agatagacat tgaccccgag gagacggtga 120 aagcactgaa agagaagatt gaatctgaaa aggggaaaga tgcctttcca gtagcaggtc 180 aaaaattaat ttatgcaggc aaaatcctca atgatgatac tgctctcaaa gaatataaaa 240 ttgatgagaa aaactttgtg gtggttatgg tgaccaaacc caaagcagtg tccacaccag 300 caccagctac aactcagcag tcagctcctg ccagcactac agcagttact tcctccacca 360 ccacaactgt ggctcaggct ccaacccctg tccctgcctt ggcccccact tccacacctg 420 catccatcac tccagcatca gcgacagcat cttctgaacc tgcacctgct agtgcagcta 480 aacaagagaa gcctgcagaa aagccagcag agacaccagt ggctactagc ccaacagcaa 540 ctgacagtac atcgggtgat tcttctcggt caaacctttt tgaagatgca acgagtgcac 600 ttgtgacggg tcagtcttac gagaatatgg taactgagat catgtcaatg ggctatgaac 660 gagagcaagt aattgcagcc ctgagagcca gtttcaacaa ccctgacaga gcagtggagt 720 atcttttaat gggaatccct ggagatagag aaagtcaggc tgtggttgac ccccctcaag 780 cagctagtac tggggttcct cagtcttcag cagtggctgc agctgcagca actacgacag 840 caacaactac aacaacaagt tctggaggac atccccttga atttttacgg aatcagcctc 900 agtttcaaca gatgagacaa attattcagc agaatccttc cttgcttcca gcgttactac 960 agcagatagg tcgagagaat cctcaattac ttcagcaaat tagccaacac caggagcatt 1020 ttattcagat gttaaatgaa ccagttcaag aagctggtgg tcaaggagga ggaggtggag 1080 gtggcagtgg aggaattgca gaagctggaa gtggtcatat gaactacatt caagtaacac 1140 ctcaggaaaa agaagctata gaaaggttaa aggcattagg atttcctgaa ggacttgtga 1200 tacaagcgta ttttgcttgt gagaagaatg agaatttggc tgccaatttt cttctacagc 1260 agaactttga tgaagattga aagggacttt tttatatctc acacttcaca ccagtgcatt 1320 acactaactt gttcactgga ttgtctggga tgacttgggc tcatatccac aatacttggt 1380 ataaggtagt agattgttgg gggtggggag ggagggatct aggatacagg gcagggataa 1440 atacagtgca tgtctgcttc aattagcaga tgccgcaact ccacacagtg tgtaaaatat 1500 atacaaccaa aaatcagctt ttgcaggtct ttatttcttc tgtaaaacag taggtaactt 1560 ttcctaggtt tcactctttt tagtgtacta gatccagaaa cttagtgtaa tgccctgctt 1620 tatatttctt tgacttaaca ttggtttcag aaagaatctt agctacctag aatttacagt 1680 ctctgtttca tggcaacact ggataatggc tttgtgaaat ttaaaaaatt tttgtagcga 1740 ctgtaaacag aaatgccaaa ttgatggtta attgttgctg cttcaaaaat aagtataaaa 1800 ttaatatgta aggaagccca ttctttcatg ttaaatactt ggggtgggag gggagaaagg 1860 gaaccttttc ttaaaatgaa aataattact gctattttaa aatttcttga tcattgaatg 1920 tgagaccctt ctaacatgat ttgagaagct gtacaagtat aggcagagtt attttcctgt 1980 ttacattttt tttttgtttt ggggaaaaaa ttggtaggtg tctaattact gtttacttca 2040 ttgttatatt gcagtaaaag ttttaaaaca aaaaaaaaaa aaaa 2084 <210> 364 <211> 2943 <212> DNA <213> Homo sapiens <400> 364 gagtcacgat gatggcggcc accatcctgt ggtgagctag cggattccct gcttgtctcg 60 ccgaccccct cgcgccttct gcagactccg tggctggcgc tcggcgcgtg aggaagcacg 120 gcggcccgag ttcgcgggga aggccgcagt cgcggaggca gcggcgcggt ccggggcacg 180 ggctggggga gaggccgctc cgctgggcga atgtgacaag cccccacccc caccgccttc 240 ctccccagag cgcgaggagc gcgggcgacc ccggggcccc gccaggccac agaccccgcc 300 cagcggccag cacccggcgc aggcccggca gccgagctgc gcggcggcac catgcaggtc 360 accctgaaga ccctccagca gcagaccttc aagatagaca ttgaccccga ggagacggtg 420 aaagcactga aagagaagat tgaatctgaa aaggggaaag atgcctttcc agtagcaggt 480 caaaaattaa tttatgcagg caaaatcctc aatgatgata ctgctctcaa agaatataaa 540 attgatgaga aaaactttgt ggtggttatg gtgaccaaac ccaaagcagt gtccacacca 600 gcaccagcta caactcagca gtcagctcct gccagcacta cagcagttac ttcctccacc 660 accacaactg tggctcaggc tccaacccct gtccctgcct tggcccccac ttccacacct 720 gcatccatca ctccagcatc agcgacagca tcttctgaac ctgcacctgc tagtgcagct 780 aaacaagaga agcctgcaga aaagccagca gagacaccag tggctactag cccaacagca 840 actgacagta catcgggtga ttcttctcgg tcaaaccttt ttgaagatgc aacgagtgca 900 cttgtgacgg gtcagtctta cgagaatatg gtaactgaga tcatgtcaat gggctatgaa 960 cgagagcaag taattgcagc cctgagagcc agtttcaaca accctgacag agcagtggag 1020 tatcttttaa tgggaatccc tggagataga gaaagtcagg ctgtggttga cccccctcaa 1080 gcagctagta ctggggctcc tcagtcttca gcagtggctg cagctgcagc aactacgaca 1140 gcaacaacta caacaacaag ttctggagga catccccttg aatttttacg gaatcagcct 1200 cagtttcaac agatgagaca aattattcag cagaatcctt ccttgcttcc agcgttacta 1260 cagcagatag gtcgagagaa tcctcaatta cttcagcaaa ttagccaaca ccaggagcat 1320 tttattcaga tgttaaatga accagttcaa gaagctggtg gtcaaggagg aggaggtgga 1380 ggtggcagtg gaggaattgc agaagctgga agtggtcata tgaactacat tcaagtaaca 1440 cctcaggaaa aagaagctat agaaaggtta aaggcattag gatttcctga aggacttgtg 1500 atacaagcgt attttgcttg tgagaagaat gagaatttgg ctgccaattt tcttctacag 1560 cagaactttg atgaagattg aaagggactt ttttatatct cacacttcac accagtgcat 1620 tacactaact tgttcactgg attgtctggg atgacttggg ctcatatcca caatacttgg 1680 tataaggtag tagattgttg ggggtgggga gggagggatc taggatacag ggcagggata 1740 aatacagtgc atgtctgctt caattagcag atgccgcaac tccacacagt gtgtaaaata 1800 tatacaacca aaaatcagct tttgcaggtc tttatttctt ctgtaaaaca gtaggtaact 1860 tttcctaggt ttcactcttt ttagtgtact agatccagaa acttagtgta atgccctgct 1920 ttatatttct ttgacttaac attggtttca gaaagaatct tagctaccta gaatttacag 1980 tctctgtttc atggcaacac tggataatgg ctttgtgaaa tttaaaaaat ttttgtagcg 2040 actgtaaaca gaaatgccaa attgatggtt aattgttgct gcttcaaaaa taagtataaa 2100 attaatatgt aaggaagccc attctttcat gttaaatact tggggtggga ggggagaaag 2160 ggaacctttt cttaaaatga aaataattac tgctatttta aaatttcttg atcattgaat 2220 gtgagaccct tctaacatga tttgagaagc tgtacaagta taggcagagt tattttcctg 2280 tttacatttt ttttttgttt tggggaaaaa attggtaggt gtctaattac tgtttacttc 2340 attgttatat tgcagtaaaa gttttaaaac aaccattgca tgtttgcttt tgatgtatcc 2400 ctttgtgaaa ttagcacttt tggggccaat ggagaaatgc agcattcact ctccctgtct 2460 tttccccttc cctcagcaga aacgtgttta tcagcaagtc gtgagtcaaa ctgctgcctt 2520 ttaaaaaacc cacaaaatgc tgattcagtt caaaattaat gcaaatgttt caaaactggg 2580 tttctgatat ttgtaaatgt gtttctttat tagataagag tgtattacca ttaaagtcat 2640 tagtataata ttgctttcaa aaagaaatgg tagacaaaac tataatccag catcttttat 2700 tgcattggaa agactggcaa agtcttttgg atgggttggg agatgtggct ggaaagtact 2760 ttggaaaata tacaatcaag atatctcatg gcatattaaa agaaaaatct taatagcagt 2820 gttggctttt atttggattt tttcatctca gttttttctg tggaatctcc ttcattggca 2880 ttgttattta atcataaacg gggcagatgt ctacttgttc agtttttcaa atctgttttc 2940 ctg 2943 <210> 365 <211> 1548 <212> DNA <213> Homo sapiens <400> 365 ggtgggggag ggagacgtag gcgtcgccac tacccctgtg tggacctggt tagccgctta 60 gttcccagag ttggtaaccc gagaagatga gccttaagaa aaaaaaaagt atcaggttcc 120 gtttgccgcc gagaggtgaa agcactgaaa gagaagattg aatctgaaaa ggggaaagat 180 gcctttccag tagcaggtca aaaattaatt tatgcaggca aaatcctcaa tgatgatact 240 gctctcaaag aatataaaat tgatgagaaa aactttgtgg tggttatggt gaccaaaccc 300 aaagcagtgt ccacaccagc accagctaca actcagcagt cagctcctgc cagcactaca 360 gcagttactt cctccaccac cacaactgtg gctcaggctc caacccctgt ccctgccttg 420 gcccccactt ccacacctgc atccatcact ccagcatcag cgacagcatc ttctgaacct 480 gcacctgcta gtgcagctaa acaagagaag cctgcagaaa agccagcaga gacaccagtg 540 gctactagcc caacagcaac tgacagtaca tcgggtgatt cttctcggtc aaaccttttt 600 gaagatgcaa cgagtgcact tgtgacgggt cagtcttacg agaatatggt aactgagatc 660 atgtcaatgg gctatgaacg agagcaagta attgcagccc tgagagccag tttcaacaac 720 cctgacagag cagtggagta tcttttaatg ggaatccctg gagatagaga aagtcaggct 780 gtggttgacc cccctcaagc agctagtact ggggttcctc agtcttcagc agtggctgca 840 gctgcagcaa ctacgacagc aacaactaca acaacaagtt ctggaggaca tccccttgaa 900 tttttacgga atcagcctca gtttcaacag atgagacaaa ttattcagca gaatccttcc 960 ttgcttccag cgttactaca gcagataggt cgagagaatc ctcaattact tcagcaaatt 1020 agccaacacc aggagcattt tattcagatg ttaaatgaac cagttcaaga agctggtggt 1080 caaggaggag gaggtggagg tggcagtgga ggaattgcag aagctggaag tggtcatatg 1140 aactacattc aagtaacacc tcaggaaaaa gaagctatag aaaggttaaa ggcattagga 1200 tttcctgaag gacttgtgat acaagcgtat tttgcttgtg agaagaatga gaatttggct 1260 gccaattttc ttctacagca gaactttgat gaagattgaa agggactttt ttatatctca 1320 cacttcacac cagtgtatta cactaacttg ttcactggat tgtctgggat gacttgggct 1380 catatccaca atacttggta taaggtagta gattgttggg ggtggggagg gagggatcta 1440 ggatacaggg cagggataaa tacagtgcat gtctgcttca attagcagat gccgcaactc 1500 cacacagtgt gtaaaatata tacaaccaaa aataaaaaaa aaaaaaaa 1548 <210> 366 <211> 2765 <212> DNA <213> Homo sapiens <400> 366 agtcacgatg atggcggcca ccatcctgtg gtgagctagc ggattccctg cttgtctcgc 60 cgaccccctc gcgccttctg cagactccgt ggctggcgct cggcgcgtga ggaagcacgg 120 cggcccgagt tcgcggggaa ggccgcagtc gcggaggcag cggcgcggtc cggggcacgg 180 gctgggggag aggccgctcc gctgggcgaa tgtgacaagc ccccaccccc accgccttcc 240 tccccagagc gcgaggagcg cgggcgcagg cccggcagcc gagctgcgcg gcggcaccat 300 gcaggtcacc ctgaagaccc tccagcagca gaccttcaag atagacattg accccgagga 360 gacggtgaaa gcactgaaag agaagattga atctgaaaag gggaaagatg cctttccagt 420 agcaggtcaa aaattaattt atgcaggcaa aatcctcaat gatgatactg ctctcaaaga 480 atataaaatt gatgagaaaa actttgtggt ggttatggtg accaaaccca aagcagtgtc 540 cacaccagca ccagctacaa ctcagcagtc agctcctgcc agtactacag cagttacttc 600 ctccaccacc acaactgtgg ctcaggctcc aacccctgtc cctgccttgg cccccacttc 660 cacacctgca tccatcactc cagcatcagc gacagcatct tctgaacctg cacctgctag 720 tgcagctaaa caagagaagc ctgcagaaaa gccagcagag acaccagtgg ctactagccc 780 aacagcaact gacagtacat cgggtgattc ttctcggtca aacctttttg aagatgcaac 840 gagtgcactt gtgacgggtc agtcttacga gaatatggta actgagatca tgtcaatggg 900 ctatgaacga gagcaagtaa ttgcagccct gagagccagt ttcaacaacc ctgacagagc 960 agtggagtat cttttaatgg gaatccctgg agatagagaa agtcaggctg tggttgaccc 1020 ccctcaagca gctagtactg gggctcctca gtcttcagca gtggctgcag ctgcagcaac 1080 tacgacagca acaactacaa caacaagttc tggaggacat ccccttgaat ttttacggaa 1140 tcagcctcag tttcaacaga tgagacaaat tattcagcag aatccttcct tgcttccagc 1200 gttactacag cagataggtc gagagaatcc tcaattactt cagcaaatta gccaacacca 1260 ggagcatttt attcagatgt taaatgaacc agttcaagaa gctggtggtc aaggaggagg 1320 aggtggaggt ggcagtggag gaattgcaga agctggaagt ggtcatatga actacattca 1380 agtaacacct caggaaaaag aagctataga aaggttaaag gcattaggat ttcctgaagg 1440 acttgtgata caagcgtatt ttgcttgtga gaagaatgag aatttggctg ccaattttct 1500 tctacagcag aactttgatg aagattgaaa gggacttttt tatatctcac acttcacacc 1560 agtgcattac actaacttgt tcactggatt gtctgggatg acttgggctc atatccacaa 1620 tacttggtat aaggtagtag attgttgggg gtggggaggg agggatctag gatacagggc 1680 agggataaat acagtgcatg tctgcttcaa ttagcagatg ccgcaactcc acacagtgtg 1740 taaaatatat acaaccaaaa atcagctttt gcaggtcttt atttcttctg taaaacagta 1800 ggtaactttt cctaggtttc actcttttta gtgtactaga tccagaaact tagtgtaatg 1860 ccctgcttta tatttctttg acttaacatt ggtttcagaa agaatcttag ctacctagaa 1920 tttacagtct ctgtttcatg gcaacactgg ataatggctt tgtgaaattt aaaaaatttt 1980 tgtagcgact gtaaacagaa atgccaaatt gatggttaat tgttgctgct tcaaaaataa 2040 gtataaaatt aatatgtaag gaagcccatt ctttcatgtt aaatacttgg ggtgggaggg 2100 gagaaaggga accttttctt aaaatgaaaa taattactgc tattttaaaa tttcttgatc 2160 attgaatgtg agacccttct aacatgattt gagaagctgt acaagtatag gcagagttat 2220 tttcctgttt acattttttt ttttgttttg gggaaaaaat tggtaggtgt ctaattactg 2280 tttacttcat tgttatattg cagtaaaagt tttaaaacaa ccattgcatg tttgcttttg 2340 atgtatccct ttgtgaaatt agcacttttg gggccaatgg agaaatgcag cattcactct 2400 ccctgtcttt tccccttccc tcagcagaaa cgtgtttatc agcaagtcgt gagtcaaact 2460 gctgcctttt aaaaaaccca caaaatgctg attcagttca aaattaatgc aaatgtttca 2520 aaactgggtt tctgatattt gtaaatgtgt ttctttatta gataagagtg tattaccatt 2580 aaagtcatta gtataatatt gctttcaaaa agaaatggta gacaaaacta taatccagca 2640 tcttttattg cattggaaag actggcaaag tcttttggat gggttgggag atgtggctgg 2700 aaagtacttt ggaaaatata caatcaagat atctcatggc atattaaaag aaaaatctta 2760 atagc 2765 <210> 367 <211> 2905 <212> DNA <213> Homo sapiens <400> 367 tagcgattcc ctgcttgtct cgccgacccc ctcgcgcctt ctgcagactc cgtggctggc 60 gctcggcgcg tgaggaagca cggcggcccg agttcgcggg gaaggccgca gtcgcggagg 120 cagcggcgcg gtccggggca cgggctgggg gagaggccgc tccgctgggc gaatgtgaca 180 agcccccacc cccaccgcct tcctccccag agcgcgagga gcgcgggcga ccccggggcc 240 ccgccaggcc acagaccccg cccagcggcc agcacccggc gcaggcccgg cagccgagct 300 gcgcggcggc accatgcagg tcaccctgaa gaccctccag cagcagacct tcaagataga 360 cattgacccc gaggagacgg tgaaagcact gaaagagaag attgaatctg aaaaggggaa 420 agatgccttt ccagtagcag gtcaaaaatt aatttatgca ggcaaaatcc tcaatgatga 480 tactgctctc aaagaatata aaattgatga gaaaaacttt gtggtggtta tggtgaccaa 540 acccaaagca gtgtccacac cagcaccagc tacaactcag cagtcagctc ctgccagcac 600 tacagcagtt acttcctcca ccaccacaac tgtggctcag gctccaaccc ctgtccctgc 660 cttggccccc acttccacac ctgcatccat cactccagca tcagcgacag catcttctga 720 acctgcacct gctagtgcag ctaaacaaga gaagcctgca gaaaagccag cagagacacc 780 agtggctact agcccaacag caactgacag tacatcgggt gattcttctc ggtcaaacct 840 ttttgaagat gcaacgagtg cacttgtgac gggtcagtct tacgagaata tggtaactga 900 gatcatgtca atgggctatg aacgagagca agtaattgca gccctgagag ccagtttcaa 960 caaccctgac agagcagtgg agtatctttt aatgggaatc cctggagata gagaaagtca 1020 ggctgtggtt gacccccctc aagcagctag tactggggct cctcagtctt cagcagtggc 1080 tgcagctgca gcaactacga cagcaacaac tacaacaaca agttctggag gacatcccct 1140 tgaattttta cggaatcagc ctcagtttca acagatgaga caaattattc agcagaatcc 1200 ttccttgctt ccagcgttac tacagcagat aggtcgagag aatcctcaat tacttcagca 1260 aattagccaa caccaggagc attttattca gatgttaaat gaaccagttc aagaagctgg 1320 tggtcaagga ggaggaggtg gaggtggcag tggaggaatt gcagaagctg gaagtggtca 1380 tatgaactac attcaagtaa cacctcagga aaaagaagct atagaaaggt taaaggcatt 1440 aggatttcct gaaggacttg tgatacaagc gtattttgct tgtgagaaga atgagaattt 1500 ggctgccaat tttcttctac agcagaactt tgatgaagat tgaaagggac ttttttatat 1560 ctcacacttc acaccagtgc attacactaa cttgttcact ggattgtctg ggatgacttg 1620 ggctcatatc cacaatactt ggtataaggt agtagattgt tgggggtggg gagggaggga 1680 tctaggatac agggcaggga taaatacagt gcatgtctgc ttcaattagc agatgccgca 1740 actccacaca gtgtgtaaaa tatatacaac caaaaatcag cttttgcagg tctttatttc 1800 ttctgtaaaa cagtaggtaa cttttcctag gtttcactct ttttagtgta ctagatccag 1860 aaacttagtg taatgccctg ctttatatat ctttgactta acattggttt cagaaagaat 1920 cttagctacc tagaatttac agtctctgtt tcatggcaac actggataat ggctttgtga 1980 aatttaaaaa atttttgtag cgactgtaaa cagaaatgcc aaattgatgg ttaattgttg 2040 ctgcttcaaa aataagtata aaattaatat gtaaggaagc ccattctttc atgttaaata 2100 cttggggtgg gaggggagaa agggaacctt ttcttaaaat gaaaataatt actgctattt 2160 taaaatttct tgatcattga atgtgagacc cttctaacat gatttgagaa gctgtacaag 2220 tataggcaga gttattttcc tgtttacatt ttttttttgt tttggggaaa aaattggtag 2280 gtgtctaatt actgtttact tcattgttat attgcagtaa aagttttaaa acaaccattg 2340 catgtttgct tttgatgtat ccctttgtga aattagcact tttggggcca atggagaaat 2400 gcagcattca ctctccctgt cttttcccct tccctcagca gaaacgtgtt tatcagcaag 2460 tcgtgagtca aactgctgcc ttttaaaaaa cccacaaaat gctgattcag ttcaaaatta 2520 atgcaaatgt ttcaaaactg ggtttctgat atttgtaaat gtgtttcttt attagataag 2580 agtgtattac cattaaagtc attagtataa tattgctttc aaaaagaaat ggtagacaaa 2640 actataatcc agcatctttt attgcattgg aaagactggc aaagtctttt ggatgggttg 2700 ggagatgtgg ctggaaagta ctttggaaaa tatacaatca agatatctca tggcatatta 2760 aaagaaaaat cttaatagca gtgttggctt ttatttggat tttttcatct cagttttttc 2820 tgtggaatct ccttcattgg cattgttatt taatcataaa cggggcagat gtctacttgt 2880 tcagtttttc aaatctgttt tcctg 2905 <210> 368 <211> 1227 <212> DNA <213> Homo sapiens <400> 368 atgcaggtca ccctgaagac cctccagccg cagaccttga cctgcaagat agacattgac 60 cccgaggaga cagtgaaagc actgaaagag aagacggaat ctgaaaaggg gaaagttgcc 120 tctctggtag caggtcaaac attaatttat gcaggcaaaa tcctcaatga tgatactgct 180 ctcaaagaat ataaaattga tgagaaaaac tttgtggtgg ttatggtgac cgaacccaaa 240 gcagtgtcca caccagcact agctacaact cagcagtcag ctcctgccag cactacagca 300 gttacttcct ccacaacaac aactgtggct caggctccaa cccctgtccc tgctttggct 360 ccccctttca cacctgcatt catcactcca gtatcagtga cagtgtcctc tgaacctgca 420 actgctagtg caactaaaca agagaaacct gcagaaaagc cagcagagac accagtggct 480 actagcctga catcaactca tagtacatca ggagattctt cttggtcaaa cctttttgaa 540 gatgcaacga gtgcacttgt gatgggtcag tcttacgata atatggtaac tgagatcatg 600 tcaatgggct atgaacgaga gcaagtaatt gcagccccaa gagccagttc caacaaccct 660 gacagggcag tggagtacct tttaatggga atccctggag ataaaagtca ggttgtggtt 720 gacccccacc aagcagctag tactggggct cctcagtctt caacagtggc tgcagctgca 780 gcaactacga cagcaacaac tacagcaagt tctgaacatc cccttgaatt tttatggaat 840 cagcctcagt ttcaacagat gagacaaatt attcaacaga gtccttccct tcttccagtg 900 ttactacagt agatagattg agagaatcct caattacttc agcaaattag ccaacaccag 960 gagcatttta ttcagatgtt aaatgaaaca gtttgagaag ctggtggtca aagaggaaga 1020 ggtggaggtg tcagtggagg aattgcagaa gctggaaatg gtcttatgaa ctacattcaa 1080 gtaatgcctc aggaaaaaga agctacagaa aggttaaagg cattaggatt tcctgaagga 1140 cttgtgatac aagcatattt tgcttgtgag aagaataaga atttgggtgc cgattttctt 1200 ctacagcaga actttgatga agattga 1227 <210> 369 <211> 4776 <212> DNA <213> Homo sapiens <400> 369 tgtatgtagg ctgggagtgt ctgctgatca cttggagtgc tgtcccttgg aacaggagga 60 gtaagattga gcacccctgc agtggaccat gagtcggtaa tgcccactga ggacctctgg 120 gagccatgtc agacgaatct gcctcaggga gcgatccaga cctggacccg gacgtggagc 180 tggaggatgc ggaagaggag gaggaggagg aggaggtggc agtggaggag tgtgacaggg 240 atgatgaaga agacctgctg gatgacccat ccctggaagg catgtgtggc actgagcatg 300 cccagttggg agaagatggg cagcagccgc cgcggtgcac ttcaactacc tcatctcagt 360 ctgagccttc agagcagctt aggcgccacc aaggcaagaa cctagcctcc gaggacccca 420 aaaagaagag agctcagaag ccctcccaca tgagaagaaa catacgaaag ctactccggg 480 aggatcaatt ggagcctgtt accaaagcag cacagcaaga agagttggaa agaaggaagc 540 gcctggagca gcagaggaaa gattatgcag cctctattcc tactgttccg ctggagttcc 600 tccctgagga aattgcttta agggcaagtg acggtcccca actgcctcct cgggtcttgg 660 cccaggaagt catttgtttg gacagtagca gtggcagtga ggatgaaaaa agcagtcgag 720 atgaggtgat tgaactgagc tctggagagg aggacactct gcacattgtg gacagcagtg 780 aatctgtcag tgaagatgat gaggaagaag agaagggtgg cacccatgtc aatgatgtct 840 taaaccagcg tgacgccctt gggcgggtcc ttgtcaacct aaaccaccct ccagaggagg 900 aaaatgtctt ccttgcccca cagttggcac gggctgtgaa acctcatcag attggcggga 960 tccggttcct ttacgataac ctagtggagt ctctggagag gtttaagacc agcagtggct 1020 ttggctgtat tctggcccac agcatgggtc tggggaaaac tttgcaagtg atctctttca 1080 tcgacgtcct cttccgccac acgccagcca aaacagtcct tgccattgtg ccggttaata 1140 ctcttcagaa ttggctggca gagttcaaca tgtggcttcc acctcctgaa gccctcccgg 1200 ctgacaacaa gcctgaagaa gtccagcctc ggttctttaa agttcacatc ttgaatgatg 1260 agcacaagac gatggcatct cgtgctaaag tgatggctga ttgggtgtca gagggtggcg 1320 tgctgctgat ggggtacgag atgtacagac tcctcactct gaagaaatca tttgccacag 1380 gtagaccgaa gaaaaccaag aagcgttctc acccagtcat cattgatcta gatgaggaag 1440 atcggcagca ggagtttcgg agagggtgca cccctacttc tcatattatt gactaagagc 1500 aggccctgtc accctctgac tccggatcct cttccctccc tagagtttga gaaggcttta 1560 tgccgccctg gccctgatgt agtaatctgt gatgagggac accgcatcaa aaactgccag 1620 gccagcacct cacaggctct gaagaatatc cgctctcgcc gccgggtggt gctgactggg 1680 taccctctgc aaaacaacct cattgagtac tggtgcatgg tggactttgt gcgcccagac 1740 ttccttggca cccggcagga gttcagcaac atgtttgaac gccctatcct gaatgggcaa 1800 tgtattgaca gcacacctca ggacgtccgc ctcatgcggt accggagcca tgtcctgcac 1860 agtcttctgg agggctttgt gcagaggaga ggccacactg tgctgaagat tcatctccct 1920 gccaaggaag aaaatgtgat ccttgtgcgg ctctccaaga tccagcgaga tttgtataca 1980 cagttcatgg atcgcttccg ggactgtggt agcagcggtt ggctggggct gaaccccctt 2040 aaggcattct gtgtgtgttg caagatctgg aatcaccctg atgtgctgta tgaagccctt 2100 cagaaggaga gcttggccaa tgagcaggac ctagacgtgg aagaacttgg ctctgcaggg 2160 accagtgccc gctgtccacc acagggaaca aaaggcaagg gagaggatag caccttggct 2220 tcctcgatgg gagaggcaac caatagcaag ttcctacagg gcgttggctt caaccctttc 2280 caggagcgag gcaacaacat tgtcacatat gaatgggcca aggaccttct gactaattac 2340 cagactggag tcctagaaaa ctctcccaag atggtactgc ttttccacct gattgaggaa 2400 agtgtgaagc ttggggacaa gatccttgtg tttagccaga gtctttccac cttggctctc 2460 atcgaggaat tccttggaaa acgagaagta ccctgtccac ctggtaccga ggggcaagga 2520 gcacagaagt gggttcgaaa catcagccac ttccatggta gcacccctgc ctttgagagg 2580 gagcggctta ttaatcagtt caatgatccc agcaacctca ccacctggct gttccttctc 2640 tctacaaggg ccggatgctt gggtgtgaat ctgattggtg ccaaccgagt ggtggtgttt 2700 gatgcttcct ggaacccttg ccatgatgcc caggcagtat gtcgggtata ccgttatggc 2760 cagaaaaagc cctgttacat ctatcgcctt gtggctgatt acactctaga aaagaagatc 2820 tatgaccgtc agatttccaa gcagggcatg tcagatcggg tggtggatga tctaaatcca 2880 atgctgaact tcacacggaa agaggtggaa aacctactgc actttgttga gaaggagcca 2940 gctccccaag tttccttgaa cgtaaagggg atcaaggagt cagtcctgca actggcctgt 3000 ctgaagtacc ctcacctcat caccaaagag cctttcgagc atgagtcatt gctcttgaac 3060 cgaaaggatc acaagctaac caaggctgag aaaaaagcag caaagaaaag ctatgaggaa 3120 gacaaacgca catcagtccc ctatacccgc ccatcgtatg cgcagtatta ccctgccagc 3180 gatcagagcc tgaccagcat ccccgccttc agccagagaa actggcagcc aactttgaag 3240 ggtgatgaaa agcctgtggc cagtgttcgt cctgtgcagt ccacccccat ccccatgatg 3300 ccccggcatg tcccattggg aggaagtgta agctctgcct ccagcacaaa tccatccatg 3360 aactttccca tcaactactt gcagcgtgca ggagtccttg tgcagaaggt ggtcaccacg 3420 acagatattg ttattcctgg actcaacagc tccacagatg tacaggcaag aattaatgct 3480 ggtgagagca tccacatcat ccgtgggaca aaagggacgt acatccgtac cagtgatgga 3540 cggatctttg ctgtccgggc aactggcaaa ccaaaggttc ctgaagatgg tcggatggct 3600 gcctcaggtt cccagggacc ttcttgcgag tccacaagca acggcagaca cagtgcctca 3660 tcacccaaag cccccgaccc tgaggggctg gccaggcccg tctctcctga cagcccagag 3720 atcatcagtg agcttcagca gtatgcagat gtggctgctg cccgggaatc ccgtcagagc 3780 tccccaagca ccaatgccgc cctgcctggc cccccggccc aacttatgga cagcagtgct 3840 gttcccggga cagctctcgg aactgagcct cgactagggg gtcattgcct caatagttcc 3900 ctcttggtga ctggccagcc ctgtggtgac aggcacccag tgctggactt aaggggccac 3960 aagcgaaagt tggccacacc acctgctgcc caggagtcat cccgccggcg gtccaggaag 4020 ggtcatctgc cagcccccgt gcagccgtat gaacacgggt atccagtctc tggcgggttt 4080 gccatgccac ccgtctcctt aaaccataac ctcaccaccc ccttcacctc ccaggctggg 4140 gagaactccc tgtttatggg cagtaccccc tcctactacc agctgtccaa tttgctggca 4200 gatgcccgcc tggtgtttcc agtgactact gaccctctgg tgccagcagg ccccgtcagt 4260 tcctcttcca cggctacctc agtcactgcc agcaacccct ccttcatgct caacccttct 4320 gtgccaggga tactacccag ctattcactc ccattctcac agccactcct gtccgagccg 4380 aggatgtttg cgccttttcc ttcccctgtc ttgcccagca acctttcgcg gggcatgtct 4440 atctatccag gctacatgtc cccacatgca ggctacccag ctggtggcct cctacggtcc 4500 caggtgcctc catttgactc tcatgaggtt gccgaggttg ggttcagctc caatgatgat 4560 gaggataaag acgatgatgt gatagaggtc actgggaaat agctagggag cccctcccca 4620 cctcacttgg ggcccccagc aggttgccca ccaagctgga aggcagtgat ttagaccttt 4680 tgagaatagg acacttggca ggagggaaaa ggaagaggac aaaggagggt ggttggccaa 4740 agtggcagag ctctgttgct gtttaacaaa agaggc 4776 <210> 370 <211> 2011 <212> DNA <213> Homo sapiens <400> 370 cgacgtccag tgctccagcc ggtgtgagga cacgatatgc tggggttttt gtccgcacgc 60 caaacgggtt tggaggaccc tcttcgcctt cggagagcag agtcaacacg gagagttttg 120 ggactggaat taaataaaga cagagatgtt gaaagaatcc acggcggtgg aattaacacc 180 cttgacattg aacctgttga agggagatac atgttatcag gtggttcaga tggtgtgatt 240 gtactttatg accttgagaa ctccagcaga caatcttatt acacatgtaa agcagtgtgt 300 tccattggca gagatcatcc tgatgttcac agatacagtg tggagactgt acagtggtat 360 cctcatgaca ctggcatgtt cacatcaagc tcatttgata aaactctgaa agtatgggat 420 acaaatacat tacaaactgc agatgtattt aattttgagg aaacagttta tagtcatcat 480 atgtctccag tctccaccaa gcactgtttg gtagcagttg gtactagagg acccaaagta 540 caactttgtg acttgaagtc tggatcctgt tctcacattc tacagggtca cagacaagaa 600 atattagcag tttcctggtc tccacgttat gactatatct tggcaacagc aagtgctgac 660 agtagagtaa aattatggga tgtgagaaga gcatcaggat gtttgattac tcttgatcaa 720 cataatggga aaaagtcaca agctgttgaa tcagcaaaca ctgctcataa tgggaaagtt 780 aatggcttat gttttacaag tgatggactt cacctcctca ctgttggtac agataatcga 840 atgaggctct ggaatagttc caatggagaa aacacacttg tgaactatgg aaaagtttgt 900 aataacagta aaaaaggatt gaaattcact gtctcctgtg gctgcagttc agaatttgtt 960 tttgtaccat atggtagcac cattgctgtt tatacagttt actcaggaga acagataact 1020 atgcttaagg gacattataa aactgttgac tgctgtgtat ttcagtcaaa tttccaggaa 1080 ctttatagtg gtagcagaga ctgcaacatt ctggcttggg ttccatcctt atatgaacca 1140 gttcctgatg atgatgagac tacaacaaaa tcacaattaa atccggcctt tgaagatgcc 1200 tggagcagca gtgatgaaga aggatgaata tcatctttag tacctttttg tctctgctga 1260 aactttttaa atgagactgt gtttttttca actgtatggt ctattcctga cagctaaatt 1320 agccctaaat gcgggtaata tttttcctca tgttttaaaa tgaggttaat atttgcataa 1380 aatcctaaaa cagacttctg tatagtttat ttagtcaaaa tgtgttcctt gatcccagat 1440 gttgtggcct gggaaagccc tcattgctac agtacaagta acacaagtcg ttgtacctca 1500 gttgtgacct tcagcagatt ttatgaacta taagatgcag tctcagagga tcagcaagtg 1560 gaggccatca gtattgactt tctcttactt gctgtactat cagcctgctc gtttccacct 1620 ttaagaatga ttttgccaag aatgattata tcaaaaatag tagttgaaat ggtaacatca 1680 aaattatttt attctttctt cttcatgtat tcacattttt cagtggtttc atttaattaa 1740 ccatgcttta tgttaaacat tttggggctc aatgtctcct actatccaaa atgtgcatca 1800 caggaggctc ttaactttgt gaaaatccca tgtttgcttt attttatttt aatgtcagaa 1860 ggcagtttgc gctaatgctt gaactctttt tctgtgaaac tcattaaggt atgaccaaat 1920 cctgcctcat taattcaagc agaaaatatc ctggcaggga atctggctta aacatgaaat 1980 gctgtaataa aatttctatg ttattgtctc a 2011 <210> 371 <211> 2011 <212> DNA <213> Homo sapiens <400> 371 cgacgtccag tgctccagcc ggtgtgagga cacgatatgc tggggttttt gtccgcacgc 60 caaacgggtt tggaggaccc tcttcgcctt cggagagcag agtcaacacg gagagttttg 120 ggactggaat taaataaaga cagagatgtt gaaagaatcc acggcggtgg aattaacacc 180 cttgacattg aacctgttga agggagatac atgttatcag gtggttcaga tggtgtgatt 240 gtactttatg accttgagaa ctccagcaga caatcttatt acacatgtaa agcagtgtgt 300 tccattggca gagatcatcc tgatgttcac agatacagtg tggagactgt acagtggtat 360 cctcatgaca ctggcatgtt cacatcaagc tcatttgata aaactctgaa agtatgggat 420 acaaatacat tacaaactgc agatgtattt aattttgagg aaacagttta tagtcatcat 480 atgtctccag tctccaccaa gcactgtttg gtagcagttg gtactagagg acccaaagta 540 caactttgtg acttgaagtc tggatcctgt tctcacattc tacagggtca cagacaagaa 600 atattagcag tttcctggtc tccacgttat gactatatct tggcaacagc aagtgctgac 660 agtagagtaa aattatggga tgtgagaaga gcatcaggat gtttgattac tcttgatcaa 720 cataatggga aaaagtcaca agctgttgaa tcagcaaaca ctgctcataa tgggaaagtt 780 aatggcttat gttttacaag tgatggactt cacctcctca ctgttggtac agataatcga 840 atgaggctct ggaatagttc caatggagaa aacacacttg tgaactatgg aaaagtttgt 900 aataacagta aaaaaggatt gaaattcact gtctcctgtg gctgcagttc agaatttgtt 960 tttgtaccat atggtagcac cattgctgtt tatacagttt actcaggaga acagataact 1020 atgcttaagg gacattataa aactgttgac tgctgtgtat ttcagtcaaa tttccaggaa 1080 ctttatagtg gtagcagaga ctgcaacatt ctggcttggg ttccatcctt atatgaacca 1140 gttcctgatg atgatgagac tacaacaaaa tcacaattaa atccggcctt tgaagatgcc 1200 tggagcagca gtgatgaaga aggatgaata tcatctttag tacctttttg tctctgctga 1260 aactttttaa atgagactgt gtttttttca actgtatggt ctattcctga cagctaaatt 1320 agccctaaat gcgggtaata tttttcctca tgttttaaaa tgaggttaat atttgcataa 1380 aatcctaaaa cagacttctg tatagtttat ttagtcaaaa tgtgttcctt gatcccagat 1440 gttgtggcct gggaaagccc tcattgctac agtacaagta acacaagtcg ttgtacctca 1500 gttgtgacct tcagcagatt ttatgaacta taagatgcag tctcagagga tcagcaagtg 1560 gaggccatca gtattgactt tctcttactt gctgtactat cagcctgctc gtttccacct 1620 ttaagaatga ttttgccaag aatgattata tcaaaaatag tagttgaaat ggtaacatca 1680 aaattatttt attctttctt cttcatgtat tcacattttt cagtggtttc atttaattaa 1740 ccatgcttta tgttaaacat tttggggctc aatgtctcct actatccaaa atgtgcatca 1800 caggaggctc ttaactttgt gaaaatccca tgtttgcttt attttatttt aatgtcagaa 1860 ggcagtttgc gctaatgctt gaactctttt tctgtgaaac tcattaaggt atgaccaaat 1920 cctgcctcat taattcaagc agaaaatatc ctggcaggga atctggctta aacatgaaat 1980 gctgtaataa aatttctatg ttattgtctc a 2011 <210> 372 <211> 2236 <212> DNA <213> Homo sapiens <400> 372 gtcatggcga cgtccagtgc tccagccggt gtgaggacac gatatgctgg ggtttttgtc 60 cgcacgccaa acgggtttgg aggaccctct tcgccttcgg agagcagagt caacacggag 120 agttttggga ctggaattaa ataaagacag agatgttgaa agaatccacg gcggtggaat 180 taacaccctt gacattgaac ctgttgaagg gagataaaat gaagcttctt atccaagatg 240 ctcaaggaaa taaaatgtga gtcaaggatt ttatatccag ccaaactgat ttcagataca 300 aaaaggacgg ataaattgtc aacaacacaa gaattcagag actgttgttc tcattagcca 360 ttccttagga atcaaccaga gaatgaaatc attcaaccag aatgacaaga gagacagcaa 420 cttaaggatt gacgcatgtt atcaggtggt tcagatggtg tgattgtact ttatgacctt 480 gagaactcca gcagacaatc ttattacaca tgtaaagcag tgtgttccat tggcagagat 540 catcctgatg ttcacagata cagtgtggag actgtacagt ggtatcctca tgacactggc 600 atgttcacat caagctcatt tgataaaact ctgaaagtat gggatacaaa tacattacaa 660 actgcagatg tatttaattt tgaggaaaca gtttatagtc atcatatgtc tccagtctcc 720 accaagcact gtttggtagc agttggtact agaggaccca aagtacaact ttgtgacttg 780 aagtctggat cctgttctca cattctacag ggtcacagac aagaaatatt agcagtttcc 840 tggtctccac gttatgacta tatcttggca acagcaagtg ctgacagtag agtaaaatta 900 tgggatgtga gaagagcatc aggatgtttg attactcttg atcaacataa tgggaaaaag 960 tcacaagctg ttgaatcagc aaacactgct cataatggga aagttaatgg cttatgtttt 1020 acaagtgatg gacttcacct cctcactgtt ggtacagata atcgaatgag gctctggaat 1080 agttccaatg gagaaaacac acttgtgaac tatggaaaag tttgtaataa cagtaaaaaa 1140 ggattgaaat tcactgtctc ctgtggctgc agttcagaat ttgtttttgt accatatggt 1200 agcaccattg ctgtttatac agtttactca ggagaacaga taactatgct taagggacat 1260 tataaaactg ttgactgctg tgtatttcag tcaaatttcc aggaacttta tagtggtagc 1320 agagactgca acattctggc ttgggttcca tccttatatg aaccagttcc tgatgatgat 1380 gagactacaa caaaatcaca attaaatccg gcctttgaag atgcctggag cagcagtgat 1440 gaagaaggat gaatatcatc tttagtacct ttttgtctct gctgaaactt tttaaatgag 1500 actgtgtttt tttcaactgt atggtctatt cctgacagct aaattagccc taaatgtggg 1560 taatattttt cctcatgttt taaaatgagg ttaatatttg cataaaatcc taaaacagac 1620 ttctgtatag tttatttagt caaaatgtgt tccttgatcc cagatgttgt ggcctgggaa 1680 agccctcatt gctacagtac aagtaacaca agtcgttgta cctcagttgt gaccttcagc 1740 agattttatg aactataaga tgcagtctca gaggatcagc aagtggaggc catcagtatt 1800 gactttctct tacttgctgt actatcagcc tgctcgtttc cacctttaag aatgattttg 1860 ccaagaatga ttatatcaaa aatagtagtt gaaatggtaa catcaaaatt attttattct 1920 ttcttcttca tgtattcaca tttttcagtg gtttcattta attaaccatg ctttatgtta 1980 aacattttgg ggctcaatgt ctcctactat ccaaaatgtg catcacagga ggcttttaac 2040 tttgtgaaaa tcccatgttt gctttatttt attttaatgt cagaaggcag tttgcgctaa 2100 tgcttgaact ctttttctgt gaaactcatt aaggtatgac caaatcctgc ctcattaatt 2160 caagcagaaa atatcctggc agggaatctg gcttaaacat gaaatgctgt aataaaattt 2220 ctatgttatt gtctcc 2236 <210> 373 <211> 916 <212> DNA <213> Homo sapiens <400> 373 gggggtcatg gcgacgtcca gtgctccagc cggtgtgagg acacgatatg ctggggtttt 60 tgtccgcacg ccaaacgggt ttggaggacc ctcttcgcct tcggagagca gagtcaacac 120 ggagagtttt gggactggaa ttaaataaag acagagatgt tgaaagaatc cacggcggtg 180 gaattaacac ccttgacatt gaacctgttg aagggagata catgttatca ggtggttcag 240 atggtgtgat tgtactttat gaccttgaga actccagcag acaatcttat tacacatgta 300 aagcagtgtg ttccattggc agagatcatc ctgatgttca cagatacagt gtggagactg 360 tacagtggta tcctcatgac actggcatgt tcacatcaag ctcatttgat aaaactctga 420 aagtatggga tacaaataca ttacaaactg cagatgtatt taattttgag gaaacagttt 480 acagtcatca tatgtctcca gtctccacca agcactgttt ggtagcagtt ggtactagag 540 gacccaaagt acaactttgt gacttgaagt ctggatcctg ttctcacatt ctacagggta 600 tttttatttt atttcaaacg gcaactactt tgagtaaacg attcaataaa aagaaacgtt 660 actaacagtg tattctttgt aagtgacatg actaatgtac tttgtgctgg ttgttgagac 720 tcagcaggga aataaagatc cttctgtgca ttattcttat aaaactgaac cattgaaaac 780 acatttatat gaacaatgat cattggggaa gctcaaacaa tatgaaaaat agttctaact 840 caaaaccttg tgttatttct acattaaaaa aactaatgca actcagaaaa aaaaaaaaaa 900 aaaaaaaaaa aaaaaa 916 <210> 374 <211> 4714 <212> DNA <213> Homo sapiens <400> 374 tgggttccaa ggcggctggc ggcggtagcg tctctgtttc cttgtgggcg ctcgcgcggc 60 cctgggtagt ctgtagagaa tgccaaatga gggaatcccc cactcaagtc aaactcagga 120 gcaagactgt ttacagagtc aacctgtcag taataatgaa gaaatggcaa tcaagcaaga 180 aagtggtggt gatggggagg tggaggagta cctgtccttt cgttctgtgg gtgacgggct 240 gtccacctct gctgtggggt gcgcatcagc agctccgagg agagggccag ccctgctgca 300 catcgaccga catcagatcc aggcagtaga gcctagcgcc caggcccttg agctgcaggg 360 tttgggtgtg gacgtctatg accaggacgt gctggaacag ggagtgcttc agcaggtgga 420 caatgccatc catgaggcca gccgtgcctc ccagctcgtt gacgtggaga aggagtatcg 480 gtcggtcctg gatgacctca cgtcatgtac gacatcccta aggcaaatca ataaaattat 540 tgaacagctt agccctcaag ctgccaccag cagagacatc aacaggaaac tagattctgt 600 aaaacgacag aagtataata aggaacaaca gctaaaaaag atcactgcaa aacaaaagca 660 tctccaggcc atccttggag gagcagaggt gaaaattgaa ctagatcacg ccagtctgga 720 ggaggatgca gagccggggc catccagtct tggcagcatg ctcatgcctg tccaggagac 780 tgcctgggaa gagctcatcc gcactggcca gatgacacct tttggtaccc agatccctca 840 gaaacaggag aaaaagccca gaaaaatcat gcttaatgaa gcatcaggct tcgaaaagta 900 tttggcagat caagcaaaac tgtcttttga aaggaagaag caaggttgta ataaaagagc 960 agctagaaaa gctccagccc cagtcacgcc tccagcccca gtgcaaaata aaaacaaacc 1020 aaacaagaaa gccagagttc tgtccaaaaa agaggagcgt ttgaaaaagc acatcaagaa 1080 actccagaag agggctttgc agttccaggg gaaagtggga ttgccaaagg caaggagacc 1140 ttgggagtca gacatgaggc cagaggcaga gggagactct gagggtgaag agtctgagta 1200 tttccccaca gaggaggagg aagaggagga agatgacgag gtggaggggg cagaggcgga 1260 cctgtctgga gatggtactg actatgagct gaagcctctg cccaagggcg ggaaacggca 1320 gaagaaagtg ccagtgcagg agattgatga tgactttttc ccaagttctg gggaagaagc 1380 tgaagctgct tctgtaggag aaggaggagg aggaggtcgg aaagtgggaa gataccgaga 1440 tgatggagat gaagattatt ataagcagcg gttaaggaga tggaataaac tgagactgca 1500 ggacaaagag aaacgtctga agctggagga cgattctgag gaaagtgatg ctgaatttga 1560 cgaaggtttt aaagtgccag gttttctgtt caaaaagctt tttaagtacc agcagacagg 1620 tgttaggtgg ctgtgggaat tgcactgcca gcaggcagga ggaattctgg gagatgaaat 1680 gggattgggc aagaccatcc agataattgc cttcttggca ggtctgagct acagcaagat 1740 caggactcgt ggttcaaatt acaggtttga ggggttgggt ccaactgtaa ttgtctgtcc 1800 aacaacagtg atgcatcagt gggtgaagga atttcacacg tggtggcctc cgttcagagt 1860 ggcaattcta catgaaaccg gttcctatac ccacaaaaag gagaaactaa ttcgagatgt 1920 tgctcattgt catggaattt tgatcacatc ttactcctac attcgattga tgcaggatga 1980 cattagcagg tatgactggc actatgtgat cttggacgaa ggacacaaaa ttcgaaatcc 2040 aaatgctgct gtcacccttg cttgcaaaca gtttcgcacc cctcatcgga tcattctgtc 2100 tggctcaccg atgcaaaata acctccgaga gctgtggtcg ctctttgact tcatcttccc 2160 gggaaagtta ggcacgttgc ctgtgtttat ggagcagttc tccgtcccca tcaccatggg 2220 gggatattca aatgcttccc cagtacaggt caaaactgct tacaagtgtg catgtgtctt 2280 acgagatacc ataaatccat acctactgcg gagaatgaag tcagatgtca agatgagcct 2340 ttctttgcca gataaaaatg aacaggtctt attttgccgt cttacagatg agcagcataa 2400 agtctaccaa aatttcgttg attccaaaga agtttacagg attctcaatg gagagatgca 2460 gattttctcc ggacttatag ccctaagaaa aatttgcaac caccctgatc tcttttctgg 2520 aggtcccaag aatctcaaag gtcttcctga tgatgaacta gaagaagatc agtttgggta 2580 ctggaaacgt tctgggaaaa tgattgttgt tgagtctttg ttgaaaatat ggcacaagca 2640 gggtcagcga gtattgctgt tttctcagtc aaggcagatg ctggacatac ttgaagtatt 2700 ccttagagcc caaaagtata cctatctcaa gatggatggt accactacaa tagcttcaag 2760 acagccactg attacgagat acaatgagga cacatccata tttgtgtttc ttctgaccac 2820 gcgggtgggc ggcttaggtg tcaacctgac gggggcaaac agagttgtca tctatgaccc 2880 agactggaac ccaagcacgg acacgcaggc ccgggagcga gcatggagaa taggccagaa 2940 gaagcaagtg actgtgtaca ggctcctgac tgcgggcacc attgaagaaa agatctacca 3000 ccgacaaatc ttcaagcagt ttttgacaaa tagagtgcta aaagacccaa aacaaaggcg 3060 gtttttcaaa tccaatgatc tctatgagct atttactctg actagtcctg atgcatccca 3120 gagcactgaa acaagtgcaa tttttgcagg aactggatca gatgttcaga cacccaaatg 3180 ccatctaaaa agaaggattc aaccagcctt tggagcagac catgatgttc caaaacgcaa 3240 gaagttccct gcttctaaca tatctgtaaa tgatgccaca tcatctgaag agaaatctga 3300 ggctaaagga gctgaagtaa atgcagtaac ttctaatcga agtgatcctt tgaaagatga 3360 ccctcacatg agtagtaatg taactagcaa tgataggctt ggagaagaga caaatgcagt 3420 atctggacca gaagagttgt cagtgattag tggaaatggg gaatgttcaa attcttcagg 3480 aacaggcaaa acttctatgc catctggtga tgaaagcatt gatgaaaagt taggtctttc 3540 ttacaaaaga gaaagaccca gccaggctca aacagaagct ttttgggaga ataaacaaat 3600 ggaaaataat ttttataagc acaagtcaaa aacaaaacat catagtgtgg cagaagaaga 3660 gaccctggag aaacatctga gaccaaagca aaagcctaag aactctaagc attgcagaga 3720 cgccaagttt gaaggaactc gaattccaca cctggtgaag aaaaggcgtt accagaagca 3780 agacagtgaa aacaagagtg aggccaagga acagagcaat gacgattatg ttttggaaaa 3840 gcttttcaaa aaatcagttg gcgtgcacag tgtcatgaag cacgatgcca tcatggatgg 3900 agccagccca gattatgtac tggtggaggc agaagccaac cgagtggccc aggatgccct 3960 gaaagcactg aggctctctc gtcagcggtg tctgggagca gtgtctggtg ttcccacctg 4020 gactggccac agggggattt ctggtgcacc agcaggaaaa aagagtagat ttggtaagaa 4080 aaggaattct aacttctctg tgcagcatcc ttcatcaaca tctccaacag agaagtgcca 4140 ggatggcatc atgaaaaagg agggaaaaga taatgtccct gagcatttta gtggaagagc 4200 agaagatgca gactcttcat ccgggcccct cgcttcctcc tcactcttgg ctaaaatgag 4260 agctagaaac cacctgattc tgccagagcg tttagaaagt gaaagcgggc acctgcagga 4320 agcttctgcc ctgctgccca ccacagaaca cgatgacctt ctggtggaga tgagaaactt 4380 catcgctttc caggcccaca ctgatggcca ggccagcacc agggagatac tgcaggagtt 4440 tgaatccaag ttatctgcat cacagtcttg tgtcttccga gaactattga gaaatctgtg 4500 cactttccat agaacttctg gtggtgaagg aatttggaaa ctcaagccag aatactgcta 4560 aacaacattg cttcctaaac tttcaagtcc ctttttctaa cgggcatttc tgattattaa 4620 tttattatta ataatcatgt ttgtcaatgg aagttggctg cacttgatgt ttgtttgcat 4680 gatgtctacc tcagaattaa aactttaagg aagg 4714 <210> 375 <211> 4714 <212> DNA <213> Homo sapiens <400> 375 tgggttccaa ggcggctggc ggcggtagcg tctctgtttc cttgtgggcg ctcgcgcggc 60 cctgggtagt ctgtagagaa tgccaaatga gggaatcccc cactcaagtc aaactcagga 120 gcaagactgt ttacagagtc aacctgtcag taataatgaa gaaatggcaa tcaagcaaga 180 aagtggtggt gatggggagg tggaggagta cctgtccttt cgttctgtgg gtgacgggct 240 gtccacctct gctgtggggt gcgcatcagc agctccgagg agagggccag ccctgctgca 300 catcgaccga catcagatcc aggcagtaga gcctagcgcc caggcccttg agctgcaggg 360 tttgggtgtg gacgtctatg accaggacgt gctggaacag ggagtgcttc agcaggtgga 420 caatgccatc catgaggcca gccgtgcctc ccagctcgtt gacgtggaga aggagtatcg 480 gtcggtcctg gatgacctca cgtcatgtac gacatcccta aggcaaatca ataaaattat 540 tgaacagctt agccctcaag ctgccaccag cagagacatc aacaggaaac tagattctgt 600 aaaacgacag aagtataata aggaacaaca gctaaaaaag atcactgcaa aacaaaagca 660 tctccaggcc atccttggag gagcagaggt gaaaattgaa ctagatcacg ccagtctgga 720 ggaggatgca gagccggggc catccagtct tggcagcatg ctcatgcctg tccaggagac 780 tgcctgggaa gagctcatcc gcactggcca gatgacacct tttggtaccc agatccctca 840 gaaacaggag aaaaagccca gaaaaatcat gcttaatgaa gcatcaggct tcgaaaagta 900 tttggcagat caagcaaaac tgtcttttga aaggaagaag caaggttgta ataaaagagc 960 agctagaaaa gctccagccc cagtcacgcc tccagcccca gtgcaaaata aaaacaaacc 1020 aaacaagaaa gccagagttc tgtccaaaaa agaggagcgt ttgaaaaagc acatcaagaa 1080 actccagaag agggctttgc agttccaggg gaaagtggga ttgccaaagg caaggagacc 1140 ttgggagtca gacatgaggc cagaggcaga gggagactct gagggtgaag agtctgagta 1200 tttccccaca gaggaggagg aagaggagga agatgacgag gtggaggggg cagaggcgga 1260 cctgtctgga gatggtactg actatgagct gaagcctctg cccaagggcg ggaaacggca 1320 gaagaaagtg ccagtgcagg agattgatga tgactttttc ccaagttctg gggaagaagc 1380 tgaagctgct tctgtaggag aaggaggagg aggaggtcgg aaagtgggaa gataccgaga 1440 tgatggagat gaagattatt ataagcagcg gttaaggaga tggaataaac tgagactgca 1500 ggacaaagag aaacgtctga agctggagga cgattctgag gaaagtgatg ctgaatttga 1560 cgaaggtttt aaagtgccag gttttctgtt caaaaagctt tttaagtacc agcagacagg 1620 tgttaggtgg ctgtgggaat tgcactgcca gcaggcagga ggaattctgg gagatgaaat 1680 gggattgggc aagaccatcc agataattgc cttcttggca ggtctgagct acagcaagat 1740 caggactcgt ggttcaaatt acaggtttga ggggttgggt ccaactgtaa ttgtctgtcc 1800 aacaacagtg atgcatcagt gggtgaagga atttcacacg tggtggcctc cgttcagagt 1860 ggcaattcta catgaaaccg gttcctatac ccacaaaaag gagaaactaa ttcgagatgt 1920 tgctcattgt catggaattt tgatcacatc ttactcctac attcgattga tgcaggatga 1980 cattagcagg tatgactggc actatgtgat cttggacgaa ggacacaaaa ttcgaaatcc 2040 aaatgctgct gtcacccttg cttgcaaaca gtttcgcacc cctcatcgga tcattctgtc 2100 tggctcaccg atgcaaaata acctccgaga gctgtggtcg ctctttgact tcatcttccc 2160 gggaaagtta ggcacgttgc ctgtgtttat ggagcagttc tccgtcccca tcaccatggg 2220 gggatattca aatgcttccc cagtacaggt caaaactgct tacaagtgtg catgtgtctt 2280 acgagatacc ataaatccat acctactgcg gagaatgaag tcagatgtca agatgagcct 2340 ttctttgcca gataaaaatg aacaggtctt attttgccgt cttacagatg agcagcataa 2400 agtctaccaa aatttcgttg attccaaaga agtttacagg attctcaatg gagagatgca 2460 gattttctcc ggacttatag ccctaagaaa aatttgcaac caccctgatc tcttttctgg 2520 aggtcccaag aatctcaaag gtcttcctga tgatgaacta gaagaagatc agtttgggta 2580 ctggaaacgt tctgggaaaa tgattgttgt tgagtctttg ttgaaaatat ggcacaagca 2640 gggtcagcga gtattgctgt tttctcagtc aaggcagatg ctggacatac ttgaagtatt 2700 ccttagagcc caaaagtata cctatctcaa gatggatggt accactacaa tagcttcaag 2760 acagccactg attacgagat acaatgagga cacatccata tttgtgtttc ttctgaccac 2820 gcgggtgggc ggcttaggtg tcaacctgac gggggcaaac agagttgtca tctatgaccc 2880 agactggaac ccaagcacgg acacgcaggc ccgggagcga gcatggagaa taggccagaa 2940 gaagcaagtg actgtgtaca ggctcctgac tgcgggcacc attgaagaaa agatctacca 3000 ccgacaaatc ttcaagcagt ttttgacaaa tagagtgcta aaagacccaa aacaaaggcg 3060 gtttttcaaa tccaatgatc tctatgagct atttactctg actagtcctg atgcatccca 3120 gagcactgaa acaagtgcaa tttttgcagg aactggatca gatgttcaga cacccaaatg 3180 ccatctaaaa agaaggattc aaccagcctt tggagcagac catgatgttc caaaacgcaa 3240 gaagttccct gcttctaaca tatctgtaaa tgatgccaca tcatctgaag agaaatctga 3300 ggctaaagga gctgaagtaa atgcagtaac ttctaatcga agtgatcctt tgaaagatga 3360 ccctcacatg agtagtaatg taactagcaa tgataggctt ggagaagaga caaatgcagt 3420 atctggacca gaagagttgt cagtgattag tggaaatggg gaatgttcaa attcttcagg 3480 aacaggcaaa acttctatgc catctggtga tgaaagcatt gatgaaaagt taggtctttc 3540 ttacaaaaga gaaagaccca gccaggctca aacagaagct ttttgggaga ataaacaaat 3600 ggaaaataat ttttataagc acaagtcaaa aacaaaacat catagtgtgg cagaagaaga 3660 gaccctggag aaacatctga gaccaaagca aaagcctaag aactctaagc attgcagaga 3720 cgccaagttt gaaggaactc gaattccaca cctggtgaag aaaaggcgtt accagaagca 3780 agacagtgaa aacaagagtg aggccaagga acagagcaat gacgattatg ttttggaaaa 3840 gcttttcaaa aaatcagttg gcgtgcacag tgtcatgaag cacgatgcca tcatggatgg 3900 agccagccca gattatgtac tggtggaggc agaagccaac cgagtggccc aggatgccct 3960 gaaagcactg aggctctctc gtcagcggtg tctgggagca gtgtctggtg ttcccacctg 4020 gactggccac agggggattt ctggtgcacc agcaggaaaa aagagtagat ttggtaagaa 4080 aaggaattct aacttctctg tgcagcatcc ttcatcaaca tctccaacag agaagtgcca 4140 ggatggcatc atgaaaaagg agggaaaaga taatgtccct gagcatttta gtggaagagc 4200 agaagatgca gactcttcat ccgggcccct cgcttcctcc tcactcttgg ctaaaatgag 4260 agctagaaac cacctgattc tgccagagcg tttagaaagt gaaagcgggc acctgcagga 4320 agcttctgcc ctgctgccca ccacagaaca cgatgacctt ctggtggaga tgagaaactt 4380 catcgctttc caggcccaca ctgatggcca ggccagcacc agggagatac tgcaggagtt 4440 tgaatccaag ttatctgcat cacagtcttg tgtcttccga gaactattga gaaatctgtg 4500 cactttccat agaacttctg gtggtgaagg aatttggaaa ctcaagccag aatactgcta 4560 aacaacattg cttcctaaac tttcaagtcc ctttttctaa cgggcatttc tgattattaa 4620 tttattatta ataatcatgt ttgtcaatgg aagttggctg cacttgatgt ttgtttgcat 4680 gatgtctacc tcagaattaa aactttaagg aagg 4714 <210> 376 <211> 2086 <212> DNA <213> Homo sapiens <400> 376 aagtgatgct gaatttgacg aaggttttaa agtgccaggt tttctgttca aaaagctttt 60 taagtaccag cagacaggtg ttaggtggct gtgggaattg cactgccagc aggcaggagg 120 aattctggga gatgaaatgg gattgggcaa gaccatccag ataattgcct tcttggcagg 180 tctgagctac agcaagatca ggactcgtgg ttcaaattac aggtttgagg ggttgggtcc 240 aactgtaatt gtctgtccaa caacagtgat gcatcagtgg gtgaaggaat ttcacacgtg 300 gtggcctccg ttcagagtgg caattctaca tgaaaccggt tcctataccc acaaaaagga 360 gaaactaatt cgagatgttg ctcattgtca tggaattttg atcacatctt actcctacat 420 tcgattgatg caggatgaca ttagcaggta tgactggcac tatgtgatct tggacgaagg 480 acacaaaatt cgaaatccaa atgctgctgt cacccttgct tgcaaacagt ttcgcacccc 540 tcatcggatc attctgtctg gctcaccgat gcaaaataac ctccgagagc tgtggtcgct 600 ctttgacttc atcttcccgg gaaagttagg cacgttgcct gtgtttatgg aacagttctc 660 cgtccccatc accatggggg gatattcaaa tgcttcccca gtacaggtca aaactgctta 720 caagtgtgca tgtgtcttac gagataccat aaatccatac ctactgcgga gaatgaagtc 780 agatgtcaag atgagccttt ctttgccaga taaaaatgaa caggtcttat tttgccgtct 840 tacagatgag cagcataaag tctaccaaaa tttcgttgat tccaaagaag tttacaggat 900 tctcaatgga gagatgcaga ttttctccgg acttatagcc ctaagaaaaa tttgcaacca 960 ccctgatctc ttttctggag gtcccaagaa tctcaaaggt cttcctgatg atgaactaga 1020 agaagatcag tttgggtact ggaaacgttc tgggaaaatg attgttgttg agtctttgtt 1080 gaaaatatgg cacaagcagg gtcagcgagt attgctgttt tctcagtcaa ggcagatgct 1140 ggacatactt gaagtattcc ttagagccca aaagtatacc tatctcaaga tggatggtac 1200 cactacaata gcttcaagac agccactgat tacgagatac aatgaggaca catccatatt 1260 tgtgtttctt ctgaccacgc gggtgggcgg cttaggtgtc aacctgacgg gggcaaacag 1320 agttgtcatc tatgacccag actggaaccc aagcacggac acgcaggccc gggagcgagc 1380 atggagaata ggccagaaga agcaagtgac tgtgtacagg ctcctgactg cgggcaccat 1440 tgaagaaaag atctaccacc gacaaatctt caagcagttt ttgacaaata gagtgctaaa 1500 agacccaaaa caaaggcggt ttttcaaatc caatgatctc tatgagctat ttactctgac 1560 tagtcctgat gcatcccaga gcactgaaac aagtgcaatt tttgcaggaa ctggatcaga 1620 tgttcagaca cccaaatgcc atctaaaaag aaggattcaa ccagcctttg gagcagacca 1680 tgatgttcca aaacgcaaga agttccctgc ttctaacata tctgtaaatg atgccacatc 1740 atctgaagag aaatctgagg ctaaaggagc tgaagtaaat gcagtaactt ctaatcgaag 1800 tgatcctttg aaagatgacc ctcacatgag tagtaatgta actagcaatg ataggcttgg 1860 agatactgca ggagtttgaa tccaagttat ctgcatcaca gtcttgtgtc ttccgagaac 1920 tattgagaaa tctgtgcact ttccatagaa cttctggtgg tgaaggaatt tggaaactca 1980 agccagaata ctgctaaaca acattgcttc ctaaactttc aagtcccttt ttctaacggg 2040 catttctgat tattaattta ttattaataa tcatgtttgt caatgg 2086 <210> 377 <211> 3854 <212> DNA <213> Homo sapiens <400> 377 gccagagtct ctccgcttta atgcgctccc attagtgccg tcccccactg gaaaaccgtg 60 gcttctgtat tatttgccat ctttgttgtg taggagcagg gagggcttcc tcccggggtc 120 ctaggcggcg gtgcagtccg tcgtagaaga attagagtag aagttgtcgg ggtccgctct 180 taggacgcag ccgcctcatg ggggtccagg ggctctggaa gctgctggag tgctccgggc 240 ggcaggtcag ccccgaagcg ctggaaggga agatcctggc tgttgatatt agcatttggt 300 taaaccaagc acttaaagga gtccgggatc gccatgggaa ctcaatagaa aatcctcatc 360 ttctcacttt gtttcatcgg ctctgcaaac tcttattttt tcgaattcgt cctatttttg 420 tgtttgatgg ggatgctcca ctattgaaga aacagacttt ggtgaagaga aggcagagaa 480 aggacttagc gtccagtgac tccaggaaaa cgacagagaa gcttctgaaa acatttttga 540 aaagacaagc catcaaaact gccttcagaa gcaaaagaga tgaagcacta cccagtctta 600 cccaagttcg aagagaaaac gacctctatg ttttgcctcc tttacaagag gaagaaaaac 660 acagttcaga agaggaagat gaaaaagaat ggcaagaaag aatgaatcaa aaacaagcat 720 tacaggaaga gttctttcat aatcctcaag cgatagatat tgagtctgag gacttcagca 780 gcctgccccc tgaagtaaag catgaaatct tgactgatat gaaagagttc accaagcgca 840 gaagaacatt atttgaagca atgccagagg agtctgatga cttttcacag taccaactca 900 aaggcttgct taaaaagaac tatctgaacc agcatataga acatgtccaa aaggaaatga 960 atcagcaaca ttcaggacac atccgaaggc agtatgaaga tgaagggggc tttctgaagg 1020 aggtagagtc aaggagagtg gtctctgaag acacttcaca ttacatcttg ataaaaggta 1080 ttcaagctaa gacagttgca gaagtggatt cagagtctct tccttcttcc agcaaaatgc 1140 acggcatgtc ttttgacgtg aagtcatctc catgtgaaaa actgaagaca gagaaagagc 1200 ctgatgctac ccctccttct ccaagaactt tactagctat gcaagctgcc ctgctgggaa 1260 gtagctcaga agaggagctg gagagtgaaa atcgaaggca ggcccgtggg aggaacgcac 1320 ctgctgctgt agacgaaggc tccatatcac cccggactct ttcagccatt aagagagctc 1380 ttgacgatga cgaagatgta aaagtgtgtg ctggggatga tgtgcagacg ggagggccag 1440 gagcagaaga aatgcgtata aacagctcca ccgagaacag tgatgaagga cttaaagtga 1500 gagatggaaa aggaataccg tttactgcaa cacttgcgtc atctagtgtg aactctgcag 1560 aggagcacgt agccagcact aatgagggga gagagcccac agactcagtt ccaaaagaac 1620 aaatgtcact tgttcacgtg gggactgaag cctttccgat aagtgatgag tctatgatta 1680 aggacagaaa agatcggctg cctctggaga gtgcagtggt tagacatagt gacgcacctg 1740 ggctcccgaa tggaagggaa ctgacaccgg catctccaac ttgtacaaat tctgtgtcaa 1800 agaatgaaac acatgctgaa gtgcttgagc agcagaacga actttgccca tatgagagta 1860 aattcgattc ttctcttctt tcaagtgatg atgaaacaaa atgtaaaccg aattctgctt 1920 ctgaagtcat tggccctgtc agtttgcaag aaacaagtag catagtaagt gtcccttcag 1980 aggcagtaga taatgtggaa aatgtggtgt catttaatgc taaagagcat gagaattttc 2040 tggaaaccat ccaagaacag cagaccactg aatctgcagg ccaggattta atttccattc 2100 caaaggccgt ggaaccaatg gaaattgact cggaagaaag tgaatctgat ggaagtttca 2160 ttgaagtgca aagtgtgatt agtgatgagg aacttcaagc agaattccct gaaacttcca 2220 aacctccctc agaacaaggc gaagaggaac tggtaggaac tagggaggga gaagcccctg 2280 ctgagtccga gagcctcctg agggacaact ctgagaggga cgacgtggat ggtgagccac 2340 aggaagctga gaaagatgcg gaagattcgc tccatgaatg gcaagatatt aatttggagg 2400 agttggaaac tctggagagc aacctcttag cacagcagaa ttcactgaaa gctcaaaaac 2460 agcagcaaga acggatcgct gctactgtca ccggacagat gttcctggaa agccaggaac 2520 tcctgcgcct gttcggcatt ccctacatcc aggctcccat ggaagcagag gcgcagtgcg 2580 ccatcctgga cctgactgat cagacttccg gaaccatcac tgatgacagt gatatctggc 2640 tgtttggagc gcggcatgtc tatagaaact tttttaataa aaacaagttt gtagaatatt 2700 atcaatatgt ggactttcac aatcaattgg gattggaccg gaataagtta ataaatttgg 2760 cttatttgct tggaagtgat tataccgaag gaataccaac tgtgggttgt gtaaccgcca 2820 tggaaattct caatgaattc cctgggcatg gcctggaacc tctcctaaaa ttctcagaat 2880 ggtggcatga agctcaaaaa aatccaaaga taagacctaa tcctcatgac accaaagtga 2940 aaaaaaaatt acggacattg caactcaccc ctggctttcc taacccagct gttgccgagg 3000 cctacctcaa acccgtggtg gatgactcga agggatcctt tctgtggggg aaacctgatc 3060 tcgacaaaat tagagaattt tgtcagcggt atttcggctg gaacagaacg aagacagatg 3120 aatctctgtt tcctgtatta aagcaactcg atgcccagca gacacagctc cgaattgatt 3180 ccttctttag attagcacaa caggagaaag aagatgctaa acgtattaag agccagagac 3240 taaacagagc tgtgacatgt atgctaagga aagagaaaga agcagcagcc agcgaaatag 3300 aagcagtttc tgttgccatg gagaaagaat ttgagctact tgataaggca aaacgaaaaa 3360 cccagaagag aggcataaca aataccttag aagagtcatc aagcctgaaa agaaagaggc 3420 tttcagattc taaacgaaag aatacatgcg gtggattttt gggggagacc tgcctctcag 3480 aatcatctga tggatcttca agtgaacatg ctgaaagttc atctttaatg aatgtacaaa 3540 ggagaacagc tgcgaaagag ccaaaaacca gtgcttcaga ttcgcagaac tcagtgaagg 3600 aagctcccgt gaagaatgga ggtgcgacca ccagcagctc tagtgatagt gatgacgatg 3660 gagggaaaga gaagatggtc ctcgtgaccg ccagatctgt gtttgggaag aaaagaagga 3720 aactaagacg tgcgagggga agaaaaagga aaacctaatt aaaaaatatg tatcctctat 3780 aattagttat gacagccatt tgtaatgaat ttgtcgcaaa gacgtaataa aattaactgg 3840 tggcacggtc aaaa 3854 <210> 378 <211> 3854 <212> DNA <213> Homo sapiens <400> 378 gccagagtct ctccgcttta atgcgctccc attagtgccg tcccccactg gaaaaccgtg 60 gcttctgtat tatttgccat ctttgttgtg taggagcagg gagggcttcc tcccggggtc 120 ctaggcggcg gtgcagtccg tcgtagaaga attagagtag aagttgtcgg ggtccgctct 180 taggacgcag ccgcctcatg ggggtccagg ggctctggaa gctgctggag tgctccgggc 240 ggcaggtcag ccccgaagcg ctggaaggga agatcctggc tgttgatatt agcatttggt 300 taaaccaagc acttaaagga gtccgggatc gccatgggaa ctcaatagaa aatcctcatc 360 ttctcacttt gtttcatcgg ctctgcaaac tcttattttt tcgaattcgt cctatttttg 420 tgtttgatgg ggatgctcca ctattgaaga aacagacttt ggtgaagaga aggcagagaa 480 aggacttagc gtccagtgac tccaggaaaa cgacagagaa gcttctgaaa acatttttga 540 aaagacaagc catcaaaact gccttcagaa gcaaaagaga tgaagcacta cccagtctta 600 cccaagttcg aagagaaaac gacctctatg ttttgcctcc tttacaagag gaagaaaaac 660 acagttcaga agaggaagat gaaaaagaat ggcaagaaag aatgaatcaa aaacaagcat 720 tacaggaaga gttctttcat aatcctcaag cgatagatat tgagtctgag gacttcagca 780 gcctgccccc tgaagtaaag catgaaatct tgactgatat gaaagagttc accaagcgca 840 gaagaacatt atttgaagca atgccagagg agtctgatga cttttcacag taccaactca 900 aaggcttgct taaaaagaac tatctgaacc agcatataga acatgtccaa aaggaaatga 960 atcagcaaca ttcaggacac atccgaaggc agtatgaaga tgaagggggc tttctgaagg 1020 aggtagagtc aaggagagtg gtctctgaag acacttcaca ttacatcttg ataaaaggta 1080 ttcaagctaa gacagttgca gaagtggatt cagagtctct tccttcttcc agcaaaatgc 1140 acggcatgtc ttttgacgtg aagtcatctc catgtgaaaa actgaagaca gagaaagagc 1200 ctgatgctac ccctccttct ccaagaactt tactagctat gcaagctgcc ctgctgggaa 1260 gtagctcaga agaggagctg gagagtgaaa atcgaaggca ggcccgtggg aggaacgcac 1320 ctgctgctgt agacgaaggc tccatatcac cccggactct ttcagccatt aagagagctc 1380 ttgacgatga cgaagatgta aaagtgtgtg ctggggatga tgtgcagacg ggagggccag 1440 gagcagaaga aatgcgtata aacagctcca ccgagaacag tgatgaagga cttaaagtga 1500 gagatggaaa aggaataccg tttactgcaa cacttgcgtc atctagtgtg aactctgcag 1560 aggagcacgt agccagcact aatgagggga gagagcccac agactcagtt ccaaaagaac 1620 aaatgtcact tgttcacgtg gggactgaag cctttccgat aagtgatgag tctatgatta 1680 aggacagaaa agatcggctg cctctggaga gtgcagtggt tagacatagt gacgcacctg 1740 ggctcccgaa tggaagggaa ctgacaccgg catctccaac ttgtacaaat tctgtgtcaa 1800 agaatgaaac acatgctgaa gtgcttgagc agcagaacga actttgccca tatgagagta 1860 aattcgattc ttctcttctt tcaagtgatg atgaaacaaa atgtaaaccg aattctgctt 1920 ctgaagtcat tggccctgtc agtttgcaag aaacaagtag catagtaagt gtcccttcag 1980 aggcagtaga taatgtggaa aatgtggtgt catttaatgc taaagagcat gagaattttc 2040 tggaaaccat ccaagaacag cagaccactg aatctgcagg ccaggattta atttccattc 2100 caaaggccgt ggaaccaatg gaaattgact cggaagaaag tgaatctgat ggaagtttca 2160 ttgaagtgca aagtgtgatt agtgatgagg aacttcaagc agaattccct gaaacttcca 2220 aacctccctc agaacaaggc gaagaggaac tggtaggaac tagggaggga gaagcccctg 2280 ctgagtccga gagcctcctg agggacaact ctgagaggga cgacgtggat ggtgagccac 2340 aggaagctga gaaagatgcg gaagattcgc tccatgaatg gcaagatatt aatttggagg 2400 agttggaaac tctggagagc aacctcttag cacagcagaa ttcactgaaa gctcaaaaac 2460 agcagcaaga acggatcgct gctactgtca ccggacagat gttcctggaa agccaggaac 2520 tcctgcgcct gttcggcatt ccctacatcc aggctcccat ggaagcagag gcgcagtgcg 2580 ccatcctgga cctgactgat cagacttccg gaaccatcac tgatgacagt gatatctggc 2640 tgtttggagc gcggcatgtc tatagaaact tttttaataa aaacaagttt gtagaatatt 2700 atcaatatgt ggactttcac aatcaattgg gattggaccg gaataagtta ataaatttgg 2760 cttatttgct tggaagtgat tataccgaag gaataccaac tgtgggttgt gtaaccgcca 2820 tggaaattct caatgaattc cctgggcatg gcctggaacc tctcctaaaa ttctcagaat 2880 ggtggcatga agctcaaaaa aatccaaaga taagacctaa tcctcatgac accaaagtga 2940 aaaaaaaatt acggacattg caactcaccc ctggctttcc taacccagct gttgccgagg 3000 cctacctcaa acccgtggtg gatgactcga agggatcctt tctgtggggg aaacctgatc 3060 tcgacaaaat tagagaattt tgtcagcggt atttcggctg gaacagaacg aagacagatg 3120 aatctctgtt tcctgtatta aagcaactcg atgcccagca gacacagctc cgaattgatt 3180 ccttctttag attagcacaa caggagaaag aagatgctaa acgtattaag agccagagac 3240 taaacagagc tgtgacatgt atgctaagga aagagaaaga agcagcagcc agcgaaatag 3300 aagcagtttc tgttgccatg gagaaagaat ttgagctact tgataaggca aaacgaaaaa 3360 cccagaagag aggcataaca aataccttag aagagtcatc aagcctgaaa agaaagaggc 3420 tttcagattc taaacgaaag aatacatgcg gtggattttt gggggagacc tgcctctcag 3480 aatcatctga tggatcttca agtgaacatg ctgaaagttc atctttaatg aatgtacaaa 3540 ggagaacagc tgcgaaagag ccaaaaacca gtgcttcaga ttcgcagaac tcagtgaagg 3600 aagctcccgt gaagaatgga ggtgcgacca ccagcagctc tagtgatagt gatgacgatg 3660 gagggaaaga gaagatggtc ctcgtgaccg ccagatctgt gtttgggaag aaaagaagga 3720 aactaagacg tgcgagggga agaaaaagga aaacctaatt aaaaaatatg tatcctctat 3780 aattagttat gacagccatt tgtaatgaat ttgtcgcaaa gacgtaataa aattaactgg 3840 tggcacggtc aaaa 3854 <210> 379 <211> 4082 <212> DNA <213> Homo sapiens <400> 379 tgcggaccca ccagcgaagg cgggaggtgt cgcagggaca tcttctggct gtttccgtcg 60 cctgcgtggc ccttgcaccc cggtcttcca ttagcggcgc agacgtttgg gcctaagcgc 120 tgggcgaggc gaggccctgc ccctccccgc caacggccat tctctggacc tgtctttctt 180 ccgggaggcg gtgacagctg ctgagacgtg ttgcagccag agtctctccg ctttaatgcg 240 ctcccattag tgccgtcccc cactggaaaa ccgtggcttc tgtattattt gccatctttg 300 ttgtgtagga gcagggaggg cttcctcccg gggtcctagg cggcggtgca gtccgtcgta 360 gaagaattag agtagaagtt gtcggggtcc gctcttagga cgcagccgcc tcatgggggt 420 ccaggggctc tggaagctgc tggagtgctc cgggcggcag gtcagccccg aagcgctgga 480 agggaagatc ctggctgttg atattagcat ttggttaaac caagcactta aaggagtccg 540 ggatcgccac gggaactcaa tagaaaatcc tcatcttctc actttgtttc atcggctctg 600 caaactctta ttttttcgaa ttcgtcctat ttttgtgttt gatggggatg ctccactatt 660 gaagaaacag actttggtga agagaaggca gagaaaggac ttagcgtcca gtgactccag 720 gaaaacgaca gagaagcttc tgaaaacatt tttgaaaaga caagccatca aaactgcctt 780 cagaagcaaa agagatgaag cactacccag tcttacccaa gttcgaagag aaaacgacct 840 ctatgttttg cctcctttac aagaggaaga aaaacacagt tcagaagagg aagatgaaaa 900 agaatggcaa gaaagaatga atcaaaaaca agcattacag gaagagttct ttcataatcc 960 tcaagcgata gatattgagt ctgaggactt cagcagcctg ccccctgaag taaagcatga 1020 aatcttgact gatatgaaag agttcaccaa gcgcagaaga acattatttg aagcaatgcc 1080 agaggagtct gatgactttt cacagtacca actcaaaggc ttgcttaaaa agaactatct 1140 gaaccagcat atagaacatg tccaaaagga aatgaatcag caacattcag gacacatccg 1200 aaggcagtat gaagatgaag ggggctttct gaaggaggta gagtcaagga gagtggtctc 1260 tgaagacact tcacattaca tcttgataaa aggtattcaa gctaagacag ttgcagaagt 1320 ggattcagag tctcttcctt cttccagcaa aatgcacggc atgtcttttg acgtgaagtc 1380 atctccatgt gaaaaactga agacagagaa agagcctgat gctacccctc cttctccaag 1440 aactttacta gctatgcaag ctgccctgct gggaagtagc tcagaagagg agctggagag 1500 tgaaaatcga aggcaggccc gtgggaggaa cgcacctgct gctgtagacg aaggctccat 1560 atcaccccgg actctttcag ccattaagag agctcttgac gatgacgaag atgtaaaagt 1620 gtgtgctggg gatgatgtgc agacgggagg gccaggagca gaagaaatgc gtataaacag 1680 ctccaccgag aacagtgatg aaggacttaa agtgagagat ggaaaaggaa taccgtttac 1740 tgcaacactt gcgtcatcta gtgtgaactc tgcagaggag cacgtagcca gcactaatga 1800 ggggagagag cccacagact cagttccaaa agaacaaatg tcacttgttc acgtggggac 1860 tgaagccttt ccgataagtg atgagtctat gattaaggac agaaaagatc ggctgcctct 1920 ggagagtgca gtggttagac atagtgacgc acctgggctc ccgaatggaa gggaactgac 1980 accggcatct ccaacttgta caaattctgt gtcaaagaat gaaacacatg ctgaagtgct 2040 tgagcagcag aacgaacttt gcccatatga gagtaaattc gattcttctc ttctttcaag 2100 tgatgatgaa acaaaatgta aaccgaattc tgcttctgaa gtcattggcc ctgtcagttt 2160 gcaagaaaca agtagcatag taagtgtccc ttcagaggca gtagataatg tggaaaatgt 2220 ggtgtcattt aatgctaaag agcatgagaa ttttctggaa accatccaag aacagcagac 2280 cactgaatct gcaggccagg atttaatttc cattccaaag gccgtggaac caatggaaat 2340 tgactcggaa gaaagtgaat ctgatggaag tttcattgaa gtgcaaagtg tgattagtga 2400 tgaggaactt caagcagaat tccctgaaac ttccaaacct ccctcagaac aaggcgaaga 2460 ggaactggta ggaactaggg agggagaagc ccctgctgag tccgagagcc tcctgaggga 2520 caactctgag agggacgacg tggatggtga gccacaggaa gctgagaaag atgcggaaga 2580 ttcgctccat gaatggcaag atattaattt ggaggagttg gaaactctgg agagcaacct 2640 cttagcacag cagaattcac tgaaagctca aaaacagcag caagaacgga tcgctgctac 2700 tgtcaccgga cagatgttcc tggaaagcca ggaactcctg cgcctgttcg gcattcccta 2760 catccaggct cccatggaag cagaggcgca gtgcgccatc ctggacctga ctgatcagac 2820 ttccggaacc atcactgatg acagtgatat ctggctgttt ggagcgcggc atgtctatag 2880 aaactttttt aataaaaaca agtttgtaga atattatcaa tatgtggact ttcacaatca 2940 attgggattg gaccggaata agttaataaa tttggcttat ttgcttggaa gtgattatac 3000 cgaaggaata ccaactgtgg gttgtgtaac cgccatggaa attctcaatg aattccctgg 3060 gcatggcctg gaacctctcc taaaattctc agaatggtgg catgaagctc aaaaaaatcc 3120 aaagataaga cctaatcctc atgacaccaa agtgaaaaaa aaattacgga cattgcaact 3180 cacccctggc tttcctaacc cagctgttgc cgaggcctac ctcaaacccg tggtggatga 3240 ctcgaaggga tcctttctgt gggggaaacc tgatctcgac aaaattagag aattttgtca 3300 gcggtatttc ggctggaaca gaacgaagac agatgaatct ctgtttcctg tattaaagca 3360 actcgatgcc cagcagacac agctccgaat tgattccttc tttagattag cacaacagga 3420 gaaagaagat gctaaacgta ttaagagcca gagactaaac agagctgtga catgtatgct 3480 aaggaaagag aaagaagcag cagccagcga aatagaagca gtttctgttg ccatggagaa 3540 agaatttgag ctacttgata aggcaaaacg aaaaacccag aagagaggca taacaaatac 3600 cttagaagag tcatcaagcc tgaaaagaaa gaggctttca gattctaaac gaaagaatac 3660 atgcggtgga tttttggggg agacctgcct ctcagaatca tctgatggat cttcaagtga 3720 agatgctgaa agttcatctt taatgaatgt acaaaggaga acagctgcga aagagccaaa 3780 aaccagtgct tcagattcgc agaactcagt gaaggaagct cccgtgaaga atggaggtgc 3840 gaccaccagc agctctagtg atagtgatga cgatggaggg aaagagaaga tggtcctcgt 3900 gaccgccaga tctgtgtttg ggaagaaaag aaggaaacta agacgtgcga ggggaagaaa 3960 aaggaaaacc taattaaaaa atatgtatcc tctataatta gttatgacag ccatttgtaa 4020 tgaatttgtc gcaaagacgt aataaaatta actggtagca cggtaaaaaa aaaaaaaaaa 4080 aa 4082 <210> 380 <211> 4048 <212> DNA <213> Homo sapiens <400> 380 tcgcagggac atcttctggc tgtttccgtc gcctgcgtgg cccttgcacc ccggtcttcc 60 attagcggcg cagacgtttg ggcctaagcg ctgggcgagg cgaggccctg cccctccccg 120 ccaacggcca ttctctggac ccgtctttct tccgggaggc ggtgacagct gctgagacgt 180 gttgcagcca gagtctctcc gctttaatgc gctcccatta gtgccgtccc ccactggaaa 240 accgtggctt ctgtattatt tgccatcttt gttgtgtagg agcagggagg gcttcctccc 300 ggggtcctag gcggcggtgc agtccgtcgt agaagaatta gagtagaagt tgtcggggtc 360 cgctcttagg acgcagccgc ctcatggggg tccaggggct ctggaagctg ctggagtgct 420 ccgggcggca ggtcagcccc gaagcgctgg aagggaagat cctggctgtt gatattagca 480 tttggttaaa ccaagcactt aaaggagtcc gggatcgcca cgggaactca atagaaaatc 540 ctcatcttct cactttgttt catcggctct gcaaactctt attttttcga attcgtccta 600 tttttgtgtt tgatggggat gctccactat tgaagaaaca gactttggtg aagagaaggc 660 agagaaagga cttagcgtcc agtgactcca ggaaaacgac agagaagctt ctgaaaacat 720 ttttgaaaag acaagccatc aaaactgcct tcagaagcaa aagagatgaa gcactaccca 780 gtcttaccca agttcgaaga gaaaacgacc tctatgtttt gcctccttta caagaggaag 840 aaaaacacag ttcagaagag gaagatgaaa aagaatggca agaaagaatg aatcaaaaac 900 aagcattaca ggaagagttc tttcataatc ctcaagcgat agatattgag tctgaggact 960 tcagcagcct gccccctgaa gtaaagcatg aaatcttgac tgatatgaaa gagttcacca 1020 agcgcagaag aacattattt gaagcaatgc cagaggagtc tgatgacttt tcacagtacc 1080 aactcaaagg cttgcttaaa aagaactatc tgaaccagca tatagaacat gtccaaaagg 1140 aagtgaatca gcaacattca ggacacatcc gaaggcagta tgaagatgaa gggggctttc 1200 tgaaggaggt agagtcaagg agagtggtct ctgaagacac ttcacattac atcttgataa 1260 aaggtattca agctaagaca gttgcagaag tggattcaga gtctcttcct tcttccagca 1320 aaatgcacgg catgtctttt gacgtgaagt catctccatg tgaaaaactg aagacagaga 1380 aagagcctga tgctacccct ccttctccaa gaactttact agctatgcaa gctgccctgc 1440 tgggaagtag ctcagaagag gagctggaga gtgaaaatcg aaggcaggcc cgtgggagga 1500 acgcacctgc tgctgtagac gaaggctcca tatcaccccg gactctttca gccattaaga 1560 gagctcttga cgatgacgaa gatgtaaaag tgtgtgctgg ggatgatgtg cagacgggag 1620 ggccaggagc agaagaaatg cgtataaaca gctccaccga gaacagtgat gaaggactta 1680 aagtgagaga tggaaaagga ataccgttta ctgcaacact tgcgtcatct agtgtgaact 1740 ctgcagagga gcacgtagcc agcactaatg aggggagaga gcccacagac tcagttccaa 1800 aagaacaaat gtcacttgtt cacgtgggga ctgaagcctt tccgataagt gatgagtcta 1860 tgattaagga cagaaaagat cggctgcctc tggagagtgc agtggttaga catagtgacg 1920 cacctgggct cccgaatgga agggaactga caccggcatc tccaacttgt acaaattctg 1980 tgtcaaagaa tgaaacacat gctgaagtgc ttgagcagca gaacgaactt tgcccatatg 2040 agagtaaatt cgattcttct cttctttcaa gtgatgatga aacaaaatgt aaaccgaatt 2100 ctgcttctga agtcattggc cctgtcagtt tgcaagaaac aagtagcata gtaagtgtcc 2160 cttcagaggc agtagataat gtggaaaatg tggtgtcatt taatgctaaa gagcatgaga 2220 attttctgga aaccatccaa gaacagcaga ccactgaatc tgcaggccag gatttaattt 2280 ccattccaaa ggccgtggaa ccaatggaaa ttgactcgga agaaagtgaa tctgatggaa 2340 gtttcattga agtgcaaagt gtgattagtg atgaggaact tcaagcagaa ttccctgaaa 2400 cttccaaacc tccctcagaa caaggcgaag aggaactggt aggaactagg gagggagaag 2460 cccctgctga gtccgagagc ctcctgaggg acaactctga gagggacgac gtggatggtg 2520 agccacagga agctgagaaa gatgcggaag attcgctcca tgaatggcaa gatattaatt 2580 tggaggagtt ggaaactctg gagagcaacc tcttagcaca gcagaattca ctgaaagctc 2640 aaaaacagca gcaagaacgg atcgctgcta ctgtcaccgg acagatgttc ctggaaagcc 2700 aggaactcct gcgcctgttc ggcattccct acatccaggc tcccatggaa gcagaggcgc 2760 agtgcgccat cctggacctg actgatcaga cttccggaac catcactgat gacagtgata 2820 tctggctgtt tggagcgcgg catgtctata gaaacttttt taataaaaat aagtttgtag 2880 aatattatca atatgtggac tttcacaatc aattgggatt ggaccggaat aagttaataa 2940 atttggctta tttgcttgga agtgattata ccgaaggaat accaactgtg ggttgtgtaa 3000 ccgccatgga aattctcaat gaattccctg ggcatggcct ggaacctctc ctaaaattct 3060 cagaatggtg gcatgaagct caaaaaaatc caaagataag acctaatcct catgacacca 3120 aagtgaaaaa aaaattacgg acattgcaac tcacccctgg ctttcctaac ccagctgttg 3180 ccgaggccta cctcaaaccc gtggtggatg actcgaaggg atcctttctg tgggggaaac 3240 ctgatctcga caaaattaga gaattttgtc agcggtattt cggctggaac agaacgaaga 3300 cagatgaatc tctgtttcct gtattaaagc aactcgatgc ccagcagaca cagctccgaa 3360 ttgattcctt ctttagatta gcacaacagg agaaagaaga tgctaaacgt attaagagcc 3420 agagactaaa cagagctgtg acatgtatgc taaggaaaga gaaagaagca gcagccagcg 3480 aaatagaagc agtttctgtt gccatggaga aagaatttga gctacttgat aaggcaaaac 3540 gaaaaaccca gaagagaggc ataacaaata ccttagaaga gtcatcaagc ctgaaaagaa 3600 agaggctttc agattctaaa cgaaagaata catgcggtgg atttttgggg gagacctgcc 3660 tctcagaatc atctgatgga tcttcaagtg aagatgctga aagttcatct ttaatgaatg 3720 tacaaaggag aacagctgcg aaagagccaa aaaccagtgc ttcagattcg cagaactcag 3780 tgaaggaagc tcccgtgaag aatggaggtg cgaccaccag cagctctagt gatagtgatg 3840 acgatggagg gaaagagaag atggtcctcg tgaccgccag atctgtgttt gggaagaaaa 3900 gaaggaaact aagacgtgcg aggggaagaa aaaggaaaac ctaattaaaa aatatgtatc 3960 ctctataatt agttatgaca gccatttgta atgaatttgt cgcaaagacg taataaaatt 4020 aactggtagc acggtcaaaa aaaaaaaa 4048 <210> 381 <211> 3922 <212> DNA <213> Homo sapiens <400> 381 cattctctgg acccgtcttt cttccgggag gcggtgacag ctgctgagac gtgttgcagc 60 cagagtctct ccgctttaat gcgctcccat tagtgccgtc ccccactgga aaaccgtggc 120 ttctgtatta tttgccatct ttgttgtgta ggagcaggga gggcttcctc ccggggtcct 180 aggcggcggt gcagtccgtc gtagaagaat tagagtagaa gttgtcgggg tccgctctta 240 ggacgcagcc gcctcatggg ggtccagggg ctctggaagc tgctggagtg ctccgggcgg 300 caggtcagcc ccgaagcgct ggaagggaag atcctggctg ttgatattag catttggtta 360 aaccaagcac ttaaaggagt ccgggatcgc cacgggaact caatagaaaa tcctcatctt 420 ctcactttgt ttcatcggct ctgcaaactc ttattttttc gaattcgtcc tatttttgtg 480 tttgatgggg atgctccact attgaagaaa cagactttgg tgaagagaag gcagagaaag 540 gacttagcgt ccagtgactc caggaaaacg acagagaagc ttctgaaaac atttttgaaa 600 agacaagcca tcaaaactgc cttcagaagc aaaagagatg aagcactacc cagtcttacc 660 caagttcgaa gagaaaacga cctctatgtt ttgcctcctt tgcaagagga agaaaaacac 720 agttcagaag aggaagatga aaaagaatgg caagaaagaa tgaatcaaaa acaagcatta 780 caggaagagt tctttcataa tcctcaagcg atagatattg agtctgagga cttcagcagc 840 ctgccccctg aagtaaagca tgaaatcttg actgatatga aagagttcac caagcgcaga 900 agaacattat ttgaagcaat gccagaggag tctgatgact tttcacagta ccaactcaaa 960 ggcttgctta aaaagaacta tctgaaccag catatagaac atgtccaaaa ggaaatgaat 1020 cagcaacatt caggacacat ccgaaggcag tatgaagatg aagggggctt tctgaaggag 1080 gtagagtcaa ggagagtggt ctctgaagac acttcacatt acatcttgat aaaaggtatt 1140 caagctaaga cagttgcaga agtggattca gagtctcttc cttcttccag caaaatgcac 1200 ggcatgtctt ttgacgtgaa gtcatctcca tgtgaaaaac tgaagacaga gaaagagcct 1260 gatgctaccc ctccttctcc aagaacttta ctagctatgc aagctgccct gctgggaagt 1320 agctcagaag aggagctgga gagtgaaaat cgaaggcagg cccgtgggag gaacgcacct 1380 gctgctgtag acgaaggctc catatcaccc cggactcttt cagccattaa gagagctctt 1440 gacgatgacg aagatgtaaa agtgtgtgct ggggatgatg tgcagacggg agggccagga 1500 gcagaagaaa tgcgtataaa cagctccacc gagaacagtg atgaaggact taaagtgaga 1560 gatggaaaag gaataccgtt tactgcaaca cttgcgtcat ctagtgtgaa ctctgcagag 1620 gagcacgtag ccagcactaa tgaggggaga gagcccacag actcagttcc aaaagaacaa 1680 atgtcacttg ttcacgtggg gactgaagcc tttccgataa gtgatgagtc tatgattaag 1740 gacagaaaag atcggctgcc tctggagagt gcagaggtta gacatagtga cgcacctggg 1800 ctcccgaatg gaagggaact gacaccggca tctccaactt gtacaaattc tgtgtcaaag 1860 aatgaaacac atgctgaagt gcttgagcag cagaacgaac tttgcccata tgagagtaaa 1920 ttcgattctt ctcttctttc aagtgatgat gaaacaaaat gtaaaccgaa ttctgcttct 1980 gaagtcattg gccctgtcag tttgcaagaa acaagtagca tagtaagtgt cccttcagag 2040 gcagtagata atgtggaaaa tgtggtgtca tttaatgcta aagagcatga gaattttctg 2100 gaaaccatcc aagaacagca gaccactgaa tctgcaggcc aggatttaat ttccattcca 2160 aaggccgtgg aaccaatgga aattgactcg gaagaaagtg aatctgatgg aagtttcatt 2220 gaagtgcaaa gtgtgattag tgatgaggaa cttcaagcag aattccctga aacttccaaa 2280 cctccctcag aacaaggcga agaggaactg gtaggaacta gggagggaga agcccctgct 2340 gagtccgaga gcctcctgag ggacaactct gagagggacg acgtggatgg tgagccacag 2400 gaagctgaga aagatgcgga agattcgctc catgaatggc aagatattaa tttggaggag 2460 ttggaaactc tggagagcaa cctcttagca cagcagaatt cactgaaagc tcaaaaacag 2520 cagcaagaac ggatcgctgc tactgtcacc ggacagatgt tcctggaaag ccaggaactc 2580 ctgcgcctgt tcggcattcc ctacatccag gctcccatgg aagcagaggc gcagtgcgcc 2640 atcctggacc tgactgatca gacttccgga accatcactg atgacagtga tatctggctg 2700 tttggagcgc ggcatgtcta tagaaacttt tttaataaaa acaagtttgt agaatattat 2760 caatatgtgg actttcacaa tcaattggga ttggaccgga ataagttaat aaatttggct 2820 tatttgcttg gaagtgatta taccgaagga ataccaactg tgggttgtgt aaccgccatg 2880 gaaattctca atgaattccc tgggcatggc ctggaacctc tcctaaaatt ctcagaatgg 2940 tggcatgaag ctcaaaaaaa tccaaagata agacctaatc ctcatgacac caaagtgaaa 3000 aaaaaattac ggacattgca actcacccct ggctttccta acccagctgt tgccgaggcc 3060 tacctcaaac ccgtggtgga tgactcgaag ggatcctttc tgtgggggaa acctgatctc 3120 gacaaaatta gagaattttg tcagcggtat ttcggctgga acagaacgaa gacagatgaa 3180 tctctgtttc ctgtattaaa gcaactcgat gcccagcaga cacagctccg aattgattcc 3240 ttctttagat tagcacaaca ggagaaagaa gatgctaaac gtattaagag ccagagacta 3300 aacagagctg tgacatgtat gctaaggaaa gagaaagaag cagcagccag cgaaatagaa 3360 gcagtttctg ttgccatgga gaaagaattt gagctacttg ataaggcaaa acgaaaaacc 3420 cagaagagag gcataacaaa taccttagaa gagtcatcaa gcctgaaaag aaagaggctt 3480 tcagattcta aacgaaagaa tacatgcggt ggatttttgg gggagacctg cctctcagaa 3540 tcatctgatg gatcttcaag tgaagatgct gaaagttcat ctttaatgaa tgtacaaagg 3600 agaacagctg cgaaagagcc aaaaaccagt gcttcagatt cgcagaactc agtgaaggaa 3660 gctcccgtga agaatggagg tgcgaccacc agcagctcta gtgatagtga tgacgatgga 3720 gggaaagaga agatggtcct cgtgaccgcc agatctgtgt ttgggaagaa aagaaggaaa 3780 ctaagacgtg cgaggggaag aaaaaggaaa acctaattaa aaaatatgta tcctctataa 3840 ttagttatga cagccatttg taatgaattt gtcgcaaaga cgtaataaaa ttaactggta 3900 gtaaaaaaaa aaaaaaaaaa aa 3922 <210> 382 <211> 3702 <212> DNA <213> Homo sapiens <400> 382 aattagagta gaagttgtcg gggtccgctc ttaggacgca gccgcctcat gggggtccag 60 gggctctgga agctgctgga gtgctccggg cggcaggtca gccccgaagc gctggaaggg 120 aagatcctgg ctgttgatat tagcatttgg ttaaaccaag cacttaaagg agtccgggat 180 cgccacggga actcaataga aaatcctcat cttctcactt tgtttcatcg gctctgcaaa 240 ctcttatttt ttcgaattcg tcctattttt gtgtttgatg gggatgctcc actattgaag 300 aaacagactt tggtgaagag aaggcagaga aaggacttag cgtccagtga ctccaggaaa 360 acgacagaga agcttctgaa aacatttttg aaaagacaag ccatcaaaac tgccttcaga 420 agcaaaagag atgaagcact acccagtctt acccaagttc gaagagaaaa cgacctctat 480 gttttgcctc ctttacaaga ggaagaaaaa cacagttcag aagaggaaga tgaaaaagaa 540 tggcaagaaa gaatgaatca aaaacaagca ttacaggaag agttctttca taatcctcaa 600 gcgatagata ttgagtctga ggacttcagc agcctgcccc ctgaagtaaa gcatgaaatc 660 ttgactgata tgaaagagtt caccaagcgc agaagaacat tatttgaagc aatgccagag 720 gagtctgatg acttttcaca gtaccaactc aaaggcttgc ttaaaaagaa ctatctgaac 780 cagcatatag aacatgtcca aaaggaagtg aatcagcaac attcaggaca catccgaagg 840 cagtatgaag atgaaggggg ctttctgaag gaggtagagt caaggagagt ggtctctgaa 900 gacacttcac attacatctt gataaaaggt attcaagcta agacagttgc agaagtggat 960 tcagagtctc ttccttcttc cagcaaaatg cacggcatgt cttttgacgt gaagtcatct 1020 ccatgtgaaa aactgaagac agagaaagag cctgatgcta cccctccttc tccaagaact 1080 ttactagcta tgcaagctgc cctgctggga agtagctcag aagaggagct ggagagtgaa 1140 aatcgaaggc aggcccgtgg gaggaacgca cctgctgctg tagacgaagg ctccatatca 1200 ccccggactc tttcagccat taagagagct cttgacgatg acgaagatgt aaaagtgtgt 1260 gctggggatg atgtgcagac gggagggcca ggagcagaag aaatgcgtat aaacagctcc 1320 accgagaaca gtgatgaagg acttaaagtg agagatggaa aaggaatacc gtttactgca 1380 acacttgcgt catctagtgt gaactctgca gaggagcacg tagccagcac taatgagggg 1440 agagagccca cagactcagt tccaaaagaa caaatgtcac ttgttcacgt ggggactgaa 1500 gcctttccga taagtgatga gtctatgatt aaggacagaa aagatcggct gcctctggag 1560 agtgcagtgg ttagacatag tgacgcacct gggctcccga atggaaggga actgacaccg 1620 gcatctccaa cttgtacaaa ttctgtgtca aagaatgaaa cacatgctga agtgcttgag 1680 cagcagaacg aactttgccc atatgagagt aaattcgatt cttctcttct ttcaagtgat 1740 gatgaaacaa aatgtaaacc gaattctgct tctgaagtca ttggccctgt cagtttgcaa 1800 gaaacaagta gcatagtaag tgtcccttca gaggcagtag ataatgtgga aaatgtggtg 1860 tcatttaatg ctaaagagca tgagaatttt ctggaaacca tccaagaaca gcagaccact 1920 gaatctgcag gccaggattt aatttccatt ccaaaggccg tggaaccaat ggaaattgac 1980 tcggaagaaa gtgaatctga tggaagtttc attgaagtgc aaagtgtgat tagtgatgag 2040 gaacttcaag cagaattccc tgaaacttcc aaacctccct cagaacaagg cgaagaggaa 2100 ctggtaggaa ctagggaggg agaagcccct gctgagtccg agagcctcct gagggacaac 2160 tctgagaggg acgacgtgga tggtgagcca caggaagctg agaaagatgc ggaagattcg 2220 ctccatgaat ggcaagatat taatttggag gagttggaaa ctctggagag caacctctta 2280 gcacagcaga attcactgaa agctcaaaaa cagcagcaag aacggatcgc tgctactgtc 2340 accggacaga tgttcctgga aagccaggaa ctcctgcgcc tgttcggcat tccctacatc 2400 caggctccca tggaagcaga ggcgcagtgc gccatcctgg acctgactga tcagacttcc 2460 ggaaccatca ctgatgacag tgatatctgg ctgtttggag cgcggcatgt ctatagaaac 2520 ttttttaata aaaataagtt tgtagaatat tatcaatatg tggactttca caatcaattg 2580 ggattggacc ggaataagtt aataaatttg gcttatttgc ttggaagtga ttataccgaa 2640 ggaataccaa ctgtgggttg tgtaaccgcc atggaaattc tcaatgaatt ccctgggcat 2700 ggcctggaac ctctcctaaa attctcagaa tggtggcatg aagctcaaaa aaatccaaag 2760 ataagaccta atcctcatga caccaaagtg aaaaaaaaat tacggacatt gcaactcacc 2820 cctggctttc ctaacccagc tgttgccgag gcctacctca aacccgtggt ggatgactcg 2880 aagggatcct ttctgtgggg gaaacctgat ctcgacaaaa ttagagaatt ttgtcagcgg 2940 tatttcggct ggaacagaac gaagacagat gaatctctgt ttcctgtatt aaagcaactc 3000 gatgcccagc agacacagct ccgaattgat tccttcttta gattagcaca acaggagaaa 3060 gaagatgcta aacgtattaa gagccagaga ctaaacagag ctgtgacatg tatgctaagg 3120 aaagagaaag aagcagcagc cagcgaaata gaagcagttt ctgttgccat ggagaaagaa 3180 tttgagctac ttgataaggc aaaacgaaaa acccagaaga gaggcataac aaatacctta 3240 gaagagtcat caagcctgaa aagaaagagg ctttcagatt ctaaacgaaa gaatacatgc 3300 ggtggatttt tgggggagac ctgcctctca gaatcatctg atggatcttc aagtgaagat 3360 gctgaaagtt catctttaat gaatgtacaa aggagaacag ctgcgaaaga gccaaaaacc 3420 agtgcttcag attcgcagaa ctcagtgaag gaagctcccg tgaagaatgg aggtgcgacc 3480 accagcagct ctagtgatag tgatgacgat ggagggaaag agaagatggt cctcgtgacc 3540 gccagatctg tgtttgggaa gaaaagaagg aaactaagac gtgcgagggg aagaaaaagg 3600 aaaacctaat taaaaaatat gtatcctcta taattagtta tgacagccat ttgtaatgaa 3660 tttgtcgcaa agacgtaata aaattaactg gtagcacggt ca 3702 <210> 383 <211> 3660 <212> DNA <213> Homo sapiens <400> 383 cacccccttc atgggggtcc agggcctctg gaagctgctg gagtgctccg ggcggcaggt 60 cagccccgaa gcgctggaag ggaagatcct ggctgttgat attagcattt ggttaaacca 120 agcacttaaa ggagtccggg atcgccatgg gaactcaata gaaaatcctc atcctctcac 180 tttgtttcat cggctctgca aactcttatt ttttcgaatt cgtcctattt ttgtgtttga 240 tggggatgct ccactattga agaaacagac tttggtgaag agaaggcaga gaaaggactt 300 agcgtccagt gactccagga aaacgacaga gaagcttctg aaaacatttt tgaaaagaca 360 agccatccaa acttccttca gaagccaaag agatgaagca ctacccagtc ttacccaagt 420 tcgaagagaa aacgacctct atgttttgcc tcctttacaa gaggaagaaa aacacagttc 480 agaagaggaa gatgaaaaag aatggcaaga aagaatgaat caaaaacaag cattacagga 540 agagttcttt cataatcctc aagcgataga tattgagtct gaggacttca gcagcctgcc 600 ccctgaagta aagcatgaaa tcttgactga tatgaaagag ttcaccaagc gcagaagaac 660 attatttgaa gcaatgccag aggagtctga tgacttttca cagtaccaac tcaaaggctt 720 gcttaaaaag aactatctga accagcatat agaacatgtc caaaaggaag tgaatcagca 780 acattcagga cacatccgaa gcagtcatga agatgaaggg ggctttctga aggaggtaga 840 gtcaaggaga gtggtctctg aagacacttc acattacatc ttgataaaag gtattcaagc 900 taagacagtt gcagaagtgg attcagagtc tcttccttct tccagcaaaa tgcacggcat 960 gtcttttgac gtgaagtcat ctccatgtga aaaactgaag acagagaaag agcctgatgc 1020 tacccctcct tctccaagaa ctttactagc tatgcaagct gccctgctgg gaagtagctc 1080 agaagaggag ctggagagtg aaaatcgaag gcaggcccgt gggaggaacg cacctgctgc 1140 tgtagacgaa ggctccatat caccccggac tctttcagcc attaagagag ctcttgacga 1200 tgacgaagat gtaaaagtgt gtgctgggga tgatgtgcag acgggagggc caggagcaga 1260 agaaatgcgt ataaacagct ccaccgagaa cagtgatgaa ggacttaaag tgagagatgg 1320 aaaaggaata ccgtttactg caacacttgc gtcatctagt gtgaactctg cagaggagca 1380 cgtagccagc actaatgagg ggagagagcc cacagactca gttccaaaag aacaaatgtc 1440 acttgttcac gtggggactg aagcctttcc gataagtgat gagtctatga ttaaggacag 1500 aaaagatcgg ctgcctctgg agagtgcagt ggttagacat agtgacgcac ctgggctccc 1560 gaatggaagg gaactgacac cggcatctcc aacttgtaca aattctgtgt caaagaatga 1620 aacacatgct gaagtgcttg agcagcagaa cgaactttgc ccatatgaga gtaaattcga 1680 ttcttctctt ctttcaagtg atgatgaaac aaaatgtaaa ccgaattctg cttctgaagt 1740 cattggccct gtcagtttgc aagaaacaag tagcatagta agtgtccctt cagaggcagt 1800 agataatgtg gaaaatgtgg tgtcatttaa tgctaaagag catgagaatt ttctggaaac 1860 catccaagaa cagcagacca ctgaatctgc aggccaggat ttaatttcca ttccaaaggc 1920 cgtggaacca atggaaattg actcggaaga aagtgaatct gatggaagtt tcattgaagt 1980 gcaaagtgtg attagtgatg aggaacttca agcagaattc cctgaaactt ccaaacctcc 2040 ctcagaacaa ggcgaagagg aactggtagg aactagggag ggagaagccc ctgctgagtc 2100 cgagagcctc ctgagggaca actctgagag ggacgacgtg gatggtgagc cacaggaagc 2160 tgagaaagat gcggaagatt cgctccatga atggcaagat attaatttgg aggagttgga 2220 aactctggag agcaacctct tagcacagca gaattcactg aaagctcaaa aacagcagca 2280 agaacggttc gctgctactg tcaccggaca gatgttcctg gaaagccagg aactcctgcg 2340 cctgttcggc attccctaca tccaggctcc catggaagca gaggcgcagt gcgcagtcct 2400 ggacctgact gatcagactt ccggaaccat cactgatgac agtgatatct ggctgtttgg 2460 agcgcggcat gtctatagaa acttttttaa taaaaacaag tttgtagaat attatcaata 2520 tgtggacttt cacaatcaat tgggattgga ccggaataag ttaataaatt tggcttattt 2580 gcttggaagt gattataccg ggaataccaa ctgtgggttg tgtaccgcca tggaaattct 2640 caatgaattc cctgggcatg gcctggaacc tctcctaaaa ttctcagaat ggtggcatga 2700 agctcaaaaa aatccaaaga taagacctaa tcctcatgac accaaagtga aaaaaaaatt 2760 acggacattg caactcaccc ctggctttcc taacccagct gttgccgagg cctacctcaa 2820 acccgtggtg gatgactcga agggatcctt tctgtggggg aaacctgatc tcgacaaaat 2880 tagcgaattt tgtcagcggt atttcggctg gaacagaacg aagacagatg aatctctgtt 2940 tcctgtatta aagcaactcg atgcccagca gacacagctc cgaattgatt ccttctttag 3000 attagcacaa caggagaaag aagatgctaa acgtattaag agccagagac taaacagagc 3060 tgtgacatgt atgctaagga aagagaaaga agcagcagcc agcgaaatag aagcagtttc 3120 tgttgccatg gagaaagaat ttgagctact tgataaggca aaacgaaaaa cccagaagag 3180 aggcataaca aataccttag aagagtcatc aagcctgaaa agaaagaggc tttcagattc 3240 taaacgaaag aatacatgcg gtggattttt gggggagacc tgcctctcag aatcatctga 3300 tggatcttca agtgaagatg ctgaaagttc atctttaatg aatgtacaaa ggagaacagc 3360 tgcgaaagag ccaaaaacca gtgcttcaga ttcgcagaac tcagtgaagg aagctcccgt 3420 gaagaatgga ggtgcgacca ccagcagctc tagtgatagt gatgacgatg gagggaaaga 3480 gaagatggtc ctcgtgaccg ccagatctgt gtttgggaag aaaagaagga aactaagacg 3540 tgcgagggga agaaaaagga aaacctaatt aaaaaatatg tatcctctat aattagttat 3600 gacagccatt tgtaatgaat ttgtgtgaaa gacgtaataa aattaactgg tagcacggtc 3660 <210> 384 <211> 3857 <212> DNA <213> Homo sapiens <400> 384 ggaagagctt ccatggagtc agggcagccg gctcgacgga ttgccatggc gccgctgctg 60 gagtacgagc gacagctggt gctggaactg ctcgacactg acgggctagt agtgtgcgcc 120 cgcgggctcg gcgcggaccg gctcctctac cactttctcc agctgcactg ccacccagcc 180 tgcctggtgc tggtgctcaa cacgcagccg gccgaggagg agtattttat caatcagctg 240 aagatagaag gagttgaaca cctccctcgc cgtgtaacaa atgaaatcac aagcaacagt 300 cgctatgaag tttacacaca aggtggtgtt atatttgcga caagtaggat acttgtggtt 360 gacttcttga ctgatagaat accttcagat ttaattactg gcatcttggt gtatagagcc 420 cacagaataa tcgagtcttg tcaagaagca ttcatcttgc gcctctttcg ccagaaaaac 480 aaacgtggtt ttattaaagc tttcacagac aatgctgttg cctttgatac tggtttttgt 540 catgtggaaa gagtgatgag aaatcttttt gtgaggaaac tgtatctgtg gccaaggttc 600 catgtagcag taaactcatt tttagaacag cacaaacctg aagttgtaga aatccatgtt 660 tctatgacac ctaccatgct tgctatacag actgctatac tggacatttt aaatgcatgt 720 ctaaaggaac taaaatgcca taacccatcg cttgaagtgg aagatttatc tttagaaaat 780 gctattggaa aaccttttga caagacaatc cgccattatc tggatccttt gtggcaccag 840 cttggagcca agactaaatc cttagttcag gatttgaaga tattacgaac tttgctgcag 900 tatctctctc agtatgattg tgtcacattt cttaatcttc tggaatctct gagagcaacg 960 gaaaaagctt ttggtcagaa ttcaggttgg ctgtttcttg actccagcac ctcgatgttt 1020 ataaatgctc gagcaagggt ttatcatctt ccagatgcca aaatgagtaa aaaagaaaaa 1080 atatctgaaa aaatggaaat taaagaaggg gaagaaacaa aaaaggaact ggtcctagaa 1140 agcaacccaa agtgggaggc actgactgaa gtattaaaag aaattgaggc agaaaataag 1200 gagagtgaag ctcttggtgg tccaggtcaa gtactgattt gtgcaagtga tgaccgaaca 1260 tgttcccagc tgagagacta tatcactctt ggagcggagg ccttcttatt gaggctctac 1320 aggaaaacct ttgagaagga tagcaaagct gaagaagtct ggatgaaatt taggaaggaa 1380 gacagttcaa agagaattag gaaatctcac aaaagaccta aagaccccca aaacaaagaa 1440 cgggcttcta ccaaagaaag aaccctcaaa aagaaaaaac ggaagttgac cttaactcaa 1500 atggtaggaa aacctgaaga actggaagag gaaggagatg tcgaggaagg atatcgtcga 1560 gaaataagca gtagcccaga aagctgcccg gaagaaatta agcatgaaga atttgatgta 1620 aatttgtcat cggatgctgc tttcggaatc ctgaaagaac ccctcactat catccatccg 1680 cttctgggtt gcagcgaccc ctatgctctg acaagggtac tacatgaagt ggagccaaga 1740 tacgtggttc tttatgacgc agagctaacc tttgttcggc agcttgaaat ttacagggcg 1800 agtaggcctg ggaaacctct gagggtttac tttcttatat acggaggttc aactgaggaa 1860 caacgctatc tcactgcttt gcggaaagaa aaggaagctt ttgaaaaact cataagggaa 1920 aaagcaagca tggttgtccc tgaagaaaga gaaggcagag atgaaacaaa cttagaccta 1980 gtaagaggca cagcatctgc agatgtttcc actgacactc ggaaagccgg tggccaggaa 2040 cagaatggta cacagcaaag catagttgtg gatatgcgtg aatttcgaag tgagcttcca 2100 tctctgatcc atcgtcgggg cattgacatt gaacccgtga ctttagaggt tggagattac 2160 atcctcactc cagaaatgtg cgtggagcgc aagagtatca gtgatttaat cggctcttta 2220 aataacggcc gcctctacag ccagtgcatc tccatgtccc gctactacaa gcgtcccgtg 2280 cttctgattg agtttgaccc tagcaagcct ttctctctca cttcccgagg tgccttgttt 2340 caggagatct ccagcaatga cattagttcc aaactcactc ttcttacact tcacttcccc 2400 agactacgga ttctctggtg cccctctcct catgcaacgg cggagttgtt tgaggagctg 2460 aaacaaagca agccacagcc tgatgcggcg acagcactgg ccattacagc agattctgaa 2520 acccttcccg agtcagagaa gtataatcct ggtccccaag acttcttgtt aaaaatgcca 2580 ggggtgaatg ccaaaaactg ccgctccttg atgcaccacg ttaagaacat cgcagaatta 2640 gcagccctgt cacaagacga gctcacgagt attctgggga atgctgcaaa tgccaaacag 2700 ctttatgatt tcattcacac ctcttttgca gaagtcgtat caaaaggaaa agggaaaaag 2760 tgaacagtga tggctgtttt cttatcccat gcctgtactt ttcagcggct ccttgccaga 2820 catcataggt cattattaat tattggtttg ctatttcatt cttttccaat gctcttaatg 2880 attgtacggt ggaccagaag ccaggattcc tctctgaact ctgcagttag gcatcacttg 2940 aacttgcctg tgcctgctct ttttcctccc tgcaccgtct atgccgggct tagcatgttt 3000 ctttttaaat gaggtttgtc aggatcaggt aaagttccta caagtgatta cagaaggtag 3060 aaactttacc tgatcctaac agatctcatt tagaaaggaa tatgctaagc ctggcatgga 3120 cggtgcaggg agggaaaaga gcaggcacaa gaaagctacc atttttaaca gtccttgtta 3180 tctagtgcaa cataaataac agtcttaatt gcacttatac ccatgtcctg tggctctcca 3240 aatctggtct ttgctgttgt gtctgctgga cgcttgaact gatgtttgtg taggaaatca 3300 tgttctgacc ctttgtctac aaaggagcct tctggaacac tgagaagaaa catctctttg 3360 ccattcctga ccagttctct ctaccacatt ttcttcagct ccatacttct gcctgtctgc 3420 tctaaggaaa tttcatggag ccttcctact actaattcaa gacagtctcc tcaaaaactg 3480 gttgactagt cttctaatga ccctaacata tgtagcatat actataattt cattgttcca 3540 aattagtatt tttaaagcaa aatgaattac ctgtttgcaa aagttaatga tgaaggagct 3600 cttagaattc tcaatttttg cacatattca gtctcctaat atcagagatc cctaagtcca 3660 gctggctagt tacagagttt tttcagactt cctcgtttct cagctcttat atcctaagac 3720 accagcatca tatcctctag aaatacaacc taattggcag tgagccgaga tcgcaccact 3780 gcacccctgc ctgggcgaca gagtgagact ttgtctctat tacaaaaaga aaagaaaaga 3840 aatacaacct aagctca 3857 <210> 385 <211> 2751 <212> DNA <213> Homo sapiens <400> 385 atggagtcag ggcagccggc tcgacggatt gccatggcgc cgctgctgga gtacgagcga 60 cagctggtgc tggaactgct cgacactgac gggctagtag tgtgcgcccg cgggctcggc 120 gcggaccggc tcctctacca ctttctccag ctgcactgcc acccagcctg cctggtgctg 180 gtgctcaaca cgcagccggc cgaggaggag tattttatca atcagctgaa gatagaagga 240 gttgaacacc tccctcgccg tgtaacaaat gaaatcacaa gcaacagtcg ctatgaagtt 300 tacacacaag gtggtgttat atttgcgaca agtaggatac ttgtggttga cttcttgact 360 gatagaatac cttcagattt aattactggc atcttggtgt atagagccca cagaataatc 420 gagtcttgtc aagaagcatt catcttgcgc ctctttcgcc agaaaaacaa acgtggtttt 480 attaaagctt tcacagacaa tgctgttgcc tttgatactg gtttttgtca tgtggaaaga 540 gtgatgagaa atctttttgt gaggaaactg tatctgtggc caaggttcca tgtagcagta 600 aactcatttt tagaacagca caaacctgaa gttgtagaaa tccatgtttc tatgacacct 660 accatgcttg ctatacagac tgctatactg gacattttaa atgcatgtct aaaggaacta 720 aaatgccata acccatcgct tgaagtggaa gatttatctt tagaaaatgc tattggaaaa 780 ccttttgaca agacaatccg ccattatctg gatcctttgt ggcaccagct tggagccaag 840 actaaatcct tagttcagga tttgaagata ttacgaactt tgctgcagta tctctctcag 900 tatgattgtg tcacatttct taatcttctg gaatctctga gagcaacgga aaaagctttt 960 ggtcagaatt caggttggct gtttcttgac tccagcacct cgatgtttat aaatgctcga 1020 gcaagggttt atcatcttcc agatgccaaa atgagtaaaa aagaaaaaat atctgaaaaa 1080 atggaaatta aagaagggga agaaacaaaa aaggaactgg tcctagaaag caacccaaag 1140 tgggaggcac tgactgaagt attaaaagaa attgaggcag aaaataagga gagtgaagct 1200 cttggtggtc caggtcaagt actgatttgt gcaagtgatg accgaacatg ttcccagctg 1260 agagactata tcactcttgg agcggaggcc ttcttattga ggctctacag gaaaaccttt 1320 gagaaggata gcaaagctga agaagtctgg atgaaattta ggaaggaaga cagttcaaag 1380 agaattagga aatctcacaa aagacctaaa gacccccaaa acaaagaacg ggcttctacc 1440 aaagaaagaa ccctcaaaaa gaaaaaacgg aagttgacct taactcaaat ggtaggaaaa 1500 cctgaagaac tggaagagga aggagatgtc gaggaaggat atcgtcgaga aataagcagt 1560 agcccagaaa gctgcccgga agaaattaag catgaagaat ttgatgtaaa tttgtcatcg 1620 gatgctgctt tcggaatcct gaaagaaccc ctcactatca tccatccgct tctgggttgc 1680 agcgacccct atgctctgac aagggtacta catgaagtgg agccaagata cgtggttctt 1740 tatgacgcag agctaacctt tgttcggcag cttgaaattt acagggcgag taggcctggg 1800 aaacctctga gggtttactt tcttatatac ggaggttcaa ctgaggaaca acgctatctc 1860 actgctttgc ggaaagaaaa ggaagctttt gaaaaactca taagggaaaa agcaagcatg 1920 gttgtccctg aagaaagaga aggcagagat gaaacaaact tagacctagt aagaggcaca 1980 gcatctgcag atgtttccac tgacactcgg aaagccggtg gccaggaaca gaatggtaca 2040 cagcaaagca tagttgtgga tatgcgtgaa tttcgaagtg agcttccatc tctgatccat 2100 cgtcggggca ttgacattga acccgtgact ttagaggttg gagattacat cctcactcca 2160 gaaatgtgcg tggagcgcaa gagtatcagt gatttaatcg gctctttaaa taacggccgc 2220 ctctacagcc agtgcatctc catgtcccgc tactacaagc gtcccgtgct tctgattgag 2280 tttgacccta gcaagccttt ctctctcact tcccgaggtg ccttgtttca ggagatctcc 2340 agcaatgaca ttagttccaa actcactctt cttacacttc acttccccag actacggatt 2400 ctctggtgcc cctctcctca tgcaacggcg gagttgtttg aggagctgaa acaaagcaag 2460 ccacagcctg atgcggcgac agcactggcc attacagcag attctgaaac ccttcccgag 2520 tcagagaagt ataatcctgg tccccaagac ttcttgttaa aaatgccagg ggtgaatgcc 2580 aaaaactgcc gctccttgat gcaccacgtt aagaacatcg cagaattagc agccctgtca 2640 caagacgagc tcacgagtat tctggggaat gctgcaaatg ccaaacagct ttatgatttc 2700 attcacacct cttttgcaga agtcgtatca aaaggaaaag ggaaaaagtg a 2751 <210> 386 <211> 2881 <212> DNA <213> Homo sapiens <400> 386 gctcgacgga ttgccatggc gccgctgctg gagtacgagc gacagctggt gctggaactg 60 ctcgacactg acgggctagt agtgtgcgcc cgcgggctcg gcgcggaccg gctcctctac 120 cactttctcc agctgcactg ccacccagcc tgcctggtgc tggtgctcaa cacgcagccg 180 gccgaggagg agtattttat caatcagctg aagatagaag gagttgaaca cctccctcgc 240 cgtgtaacaa atgaaatcac aagcaacagt cgctatgaag tttacacaca aggtggtgtt 300 atatttgcga caagtaggat acttgtggtt gacttcttga ctgatagaat accttcagat 360 ttaattactg gcatcttggt gtatagagcc cacagaataa tcgagtcttg tcaagaagca 420 ttcatcttgc gcctctttcg ccagaaaaac aaacgtggtt ttattaaagc tttcacagac 480 aatgctgttg cctttgatac tggtttttgt catgtggaaa gagtgatgag aaatcttttt 540 gtgaggaaac tgtatctgtg gccaaggttc catgtagcag taaactcatt tttagaacag 600 cacaaacctg aagttgtaga aatccatgtt tctatgacac ctaccatgct tgctatacag 660 actgctatac tggacatttt aaatgcatgt ctaaaggaac taaaatgcca taacccatcg 720 cttgaagtgg aagatttatc tttagaaaat gctattggaa aaccttttga caagacaatc 780 cgccattatc tggatccttt gtggcaccag cttggagcca agactaaatc cttagttcag 840 gatttgaaga tattacgaac tttgctgcag tatctctctc agtatgattg tgtcacattt 900 cttaatcttc tggaatctct gagagcaacg gaaaaagctt ttggtcagaa ttcaggttgg 960 ctgtttcttg actccagcac ctcgatgttt ataaatgctc gagcaagggt ttatcatctt 1020 ccagatgcca aaatgagtaa aaaagaaaaa atatctgaaa aaatggaaat taaagaaggg 1080 gaagaaacaa aaaaggaact ggtcctagaa agcaacccaa agtgggaggc actgactgaa 1140 gtattaaaag aaattgaggc agaaaataag gagagtgaag ctcttggtgg tccaggtcaa 1200 gtactgattt gtgcaagtga tgaccgaaca tgttcccagc tgagagacta tatcactctt 1260 ggagcggagg ccttcttatt gaggctctac aggaaaacct ttgagaagga tagcaaagct 1320 gaagaagtct ggatgaaatt taggaaggaa gacagttcaa agagaattag gaaatctcac 1380 aaaagaccta aagaccccca aaacaaagaa cgggcttcta ccaaagaaag aaccctcaaa 1440 aagaaaaaac ggaagttgac cttaactcaa atggtaggaa aacctgaaga actggaagag 1500 gaaggagatg tcgaggaagg atatcgtcga gaaataagca gtagcccaga aagctgcccg 1560 gaagaaatta agcatgaaga atttgatgta aatttgtcat cggatgctgc tttcggaatc 1620 ctgaaagaac ccctcactat catccatccg cttctgggtt gcagcgaccc ctatgctctg 1680 acaagggtac tacatgaagt ggagccaaga tacgtggttc tttatgacgc agagctaacc 1740 tttgttcggc agcttgaaat ttacagggcg agtaggcctg ggaaacctct gagggtttac 1800 tttcttatat acggaggttc aactgaggaa caacgctatc tcactgcttt gcggaaagaa 1860 aaggaagctt ttgaaaaact cataagggaa aaagcaagca tggttgtccc tgaagaaaga 1920 gaaggcagag atgaaacaaa cttagaccta gtaagaggca cagcatctgc agatgtttcc 1980 actgacactc ggaaagccgg tggccaggaa cagaatggta cacagcaaag catagttgtg 2040 gatatgcgtg aatttcgaag tgagcttcca tctctgatcc atcgtcggga cattgacatt 2100 gaacccgtga ctttagaggt tggagattac atcctcactc cagaaatgtg cgtggagcgc 2160 aagagtatca gtgatttaat cggctcttta aataacggcc gcctctacag ccagtgcatc 2220 tccatgtccc gctactacaa gcgtcccgtg cttctgattg agtttgaccc tagcaagcct 2280 ttctctctca cttcccgagg tgccttgttt caggagatct ccagcaatga cattagttcc 2340 aaactcactc ttcttacact tcacttcccc agactacgga ttctctggtg cccctctcct 2400 catgcaacgg cggagttgtt tgaggagctg aaacaaagca agccacagcc tgatgcggcg 2460 acagcactgg ccattacagc agattccgaa acccttcccg agtcagagaa gtataatcct 2520 ggtccccaag acttcttgtt aaaaatgcca ggggtgaatg ccaaaaactg ccgctccttg 2580 atgcaccacg ttaagaacat cgcagaatta gcagccctgt cacaagacga gctcacgagt 2640 attctgggga atgctgcaaa tgccaaacag ctttatgatt tcattcacac ctcttttgca 2700 gaagtcgtat caaaaggaaa agggaaaaag tgaacagtga tggctgtttt cttatcccat 2760 gcctgtactt ttcagcggct ccttgccaga catcataggt cattattaat tattggtttg 2820 ctatttcatt cttttccaat gctcttaatg attgtacggt ggaccagagt tcagagagcc 2880 c 2881 <210> 387 <211> 1083 <212> DNA <213> Homo sapiens <400> 387 tcgacggatt gccatggcgc cgctgctgga gtacgagcga cagctggtgc tggaactgct 60 cgacactgac gggctagtag tgtgcgcccg cgggctcggc gcggaccggc tcctctacca 120 ctttctccag ctgcactgcc acccagcctg cctggtgctg gtgctcaaca cgcagccggc 180 cgaggaggag tattttatca atcagctgaa gatagaagga gttgaacacc tccctcgccg 240 tgtaacaaat gaaatcacaa gcaacagtcg ctatgaagtt tacacacaag gtggtgttat 300 atttgcgaca agtaggatac ttgtggttga cttcttgact gatagaatac cttcagattt 360 aattactggc atcttggtgt atagagccca cagaataatc gagtcttgtc aagaagcatt 420 catcttgcgc ctctttcgcc agaaaaacaa acgtggtttt attaaagctt tcacagacaa 480 tgctgttgcc tttgatactg gtttttgtca tgtggaaaga gtgatgagaa atctttttgt 540 gaggaaactg tatctgtggc caaggttcca tgtagcagta aactcatttt tagaacagca 600 caaacctgaa gttgtagaaa tccatgtttc tatgacacct accatgcttg ctatacagac 660 tgctatactg gacattttaa atgcatgtct aaaggaacta aaatgccata acccatcgct 720 tgaagtggaa gatttatctt tagaaaatgc tattggaaaa ccttttgaca agacaatccg 780 ccattatctg gatcctttgt ggcaccagct tggagccaag actaaatcct tagttcagga 840 tttgaagata ttacgaactt tgctgcagta tctctctcag tatgattgtg tcacatttct 900 taatcttctg gaatctctga gagcaacgga aaaagctttt ggtcagaatt caggttggct 960 gtttcttgac tccagcacct cgatgtttat aaatgctcga gcaagggttt atcatcttcc 1020 agatgccaaa atgagtaaaa aagaaaaaat atccaaaaaa aaaaaaaaaa aaaaaaaaaa 1080 aaa 1083 <210> 388 <211> 4221 <212> DNA <213> Homo sapiens <400> 388 cagcggcagt ggagttcgct gcgcgctgtt gggggccacc tgtcttttcg cttgtgtccc 60 tctttctagt gtcgcgctcg agtcccgacg ggccgctcca agcctcgaca tgtcgtacaa 120 ctacgtggta acggcccaga agcccaccgc cgtgaacggc tgcgtgaccg gacactttac 180 ttcggccgaa gacttaaacc tgttgattgc caaaaacacg agattagaga tctatgtggt 240 caccgccgag gggcttcggc ccgtcaaaga ggtgggcatg tatgggaaga ttgcggtcat 300 ggagcttttc aggcccaagg gggagagcaa ggacctgctg tttatcttga cagcgaagta 360 caatgcctgc atcctggagt ataaacagag tggcgagagc attgacatca ttacgcgagc 420 ccatggcaat gtccaggacc gcattggccg cccctcagag accggcatta ttggcatcat 480 tgaccctgag tgccggatga ttggcctgcg tctctatgat ggccttttca aggttattcc 540 actagatcgc gataataaag aactcaaggc cttcaacatc cgcctggagg agctgcatgt 600 cattgatgtc aagttcctat atggttgcca agcacctact atttgctttg tctaccagga 660 ccctcagggg cggcacgtaa aaacctatga ggtgtctctc cgagaaaagg aattcaataa 720 gggcccttgg aaacaggaaa atgtcgaagc tgaagcttcc atggtgatcg cagtcccaga 780 gccctttggg ggggccatca tcattggaca ggagtcaatc acctatcaca atggtgacaa 840 atacctggct attgcccctc ctatcatcaa gcaaagcacg attgtgtgcc acaatcgagt 900 ggaccctaat ggctcaagat acctgctggg agacatggaa ggccggctct tcatgctgct 960 tttggagaag gaggaacaga tggatggcac cgtcactctc aaggatctcc gtgtagaact 1020 ccttggagag acctctattg ctgagtgctt gacatacctt gataatggtg ttgtgtttgt 1080 cgggtctcgc ctgggtgact cccagcttgt gaagctcaac gttgacagta atgaacaagg 1140 ctcctatgta gtggccatgg aaacctttac caacttagga cccattgtcg atatgtgcgt 1200 ggtggacctg gagaggcagg ggcaggggca gctggtcact tgctctgggg ctttcaagga 1260 aggttctttg cggatcatcc ggaatggaat tggaatccac gagcatgcca gcattgactt 1320 accaggcatc aaaggattat ggccactgcg gtctgaccct aatcgtgaga cttatgacac 1380 tttggtgctc tcttttgtgg gccagacaag agttctcatg ttaaatggag aggaggtaga 1440 agaaaccgaa ctgatgggtt tcgtggatga tcagcagact ttcttctgtg gcaacgtggc 1500 tcatcagcag cttatccaga tcacttcagc atcggtgagg ttggtctctc aagaacccaa 1560 agctctggtc agtgaatgga aggagcctca ggccaagaac atcagtgtgg cctcctgcaa 1620 tagcagccag gtggtggtgg ctgtaggcag ggccctctac tatctgcaga tccatcctca 1680 ggagctccgg cagatcagcc acacagagat ggaacatgaa gtggcttgct tggacatcac 1740 cccattagga gacagcaatg gactgtcccc tctttgtgcc attggcctct ggacggacat 1800 ctcggctcgt atcttgaagt tgccctcttt tgaactactg cacaaggaga tgctgggtgg 1860 agagatcatt cctcgctcca tcctgatgac cacctttgag agtagccatt acctcctttg 1920 tgccttggga gatggagcgc ttttctactt tgggctcaac attgagacag gtctgttgag 1980 cgaccgtaag aaggtgactt tgggcaccca gcccaccgta ttgaggactt ttcgttctct 2040 ttctaccacc aacgtctttg cttgttctga ccgccccact gtcatctata gcagcaacca 2100 caaattggtc ttctcaaatg tcaacctcaa ggaagtgaac tacatgtgtc ccctcaattc 2160 agatggctat cctgacagcc tggcgctggc caacaatagc accctcacca ttggcaccat 2220 cgatgagatc cagaagctgc acattcgcac agttcccctc tatgagtctc caaggaagat 2280 ctgctaccag gaagtgtccc agtgtttcgg ggtcctctcc agccgcattg aagtccaaga 2340 cacgagtggg ggcacgacag ccttgaggcc cagcgctagc acccaggctc tgtccagcag 2400 tgtaagctcc agcaagctgt tctccagcag cactgctcct catgagacct cctttggaga 2460 agaggtggag gtgcataacc tacttatcat tgaccaacac acctttgaag tgcttcatgc 2520 ccaccagttt ctgcagaatg aatatgccct cagtctggtt tcctgcaagc tgggcaaaga 2580 ccccaacact tacttcattg tgggcacagc aatggtgtat cctgaagagg cagagcccaa 2640 gcagggtcgc attgtggtct ttcagtattc ggatggaaaa ctacagactg tggctgaaaa 2700 ggaagtgaaa ggggccgtgt actctatggt ggaatttaac gggaagctgt tagccagcat 2760 caatagcacg gtgcggctct atgagtggac aacagagaag gacgtgcgca ctgagtgcaa 2820 ccactacaac aacatcatgg ccctctacct gaagaccaag ggcgacttca tcctggtggg 2880 cgaccttatg cgctcagtgc tgctgcttgc ctacaagccc atggaaggaa actttgaaga 2940 gattgctcga gactttaatc ccaactggat gagtgctgtg gaaatcttgg atgatgacaa 3000 ttttctgggg gctgaaaatg cctttaactt gtttgtgtgt caaaaggata gcgctgccac 3060 cactgacgag gagcggcagc acctccagga ggttggtctt ttccacctgg gcgagtttgt 3120 caatgtcttt tgccacggct ctctggtaat gcagaatctg ggtgagactt ccacccccac 3180 acaaggctcg gtgctcttcg gcacggtcaa cggcatgata gggctggtga cctcactgtc 3240 agagagctgg tacaacctcc tgctggacat gcagaatcga ctcaataaag tcatcaaaag 3300 tgtggggaag atcgagcact ccttctggag atcctttcac accgagcgga agacagaacc 3360 agccacaggt ttcatcgacg gtgacttgat tgagagtttc ctggatatta gccgccccaa 3420 gatgcaggag gtggtggcaa acctacagta tgacgatggc agcggtatga agcgagaggc 3480 cactgcagac gacctcatca aggttgtgga ggagctaact cggatccatt agccaagggc 3540 agggggcccc tttgctgacc ctccccaaag gctttgccct gctgccctcc ccctcctctc 3600 caccatcgtc ttcttggcca tgggaggcct ttccctaagc cagctgcccc cagagccaca 3660 gttcccctat gtggaagtgg ggcgggcttc atagagactt gggaatgagc tgaaggtgaa 3720 acattttctc cctggatttt taccagtctc acatgattcc agccatcacc ttagaccacc 3780 aagccttgat tggtgttgcc agttgtcctc cttccgggga aggattttgc agttctttgg 3840 ctgaaaggaa gctgtgcgtg tgtgtgtgtg tatgtgtgtg tgtgtatgtg tatctcacac 3900 tcatgcattg tcctcttttt atttagattg gcagtgtagg gagttgtggg tagtggggaa 3960 gagggttagg agggtttcat tgtctgtgaa gtgagacctt ccttttactt ttcttctatt 4020 gcctctgaga gcatcaggcc tagaggcctg actgccaagc catgggtagc ctgggtgtaa 4080 aacctggaga tggtggatga tccccacgcc acagcccttt tgtctctgca aactgccttc 4140 ttcggaaaga agaaggtggg aggatgtgaa ttgttagttt ctgagtttta ccaaataaag 4200 tagaatataa gaagaaaaaa a 4221 <210> 389 <211> 4221 <212> DNA <213> Homo sapiens <400> 389 cagcggcagt ggagttcgct gcgcgctgtt gggggccacc tgtcttttcg cttgtgtccc 60 tctttctagt gtcgcgctcg agtcccgacg ggccgctcca agcctcgaca tgtcgtacaa 120 ctacgtggta acggcccaga agcccaccgc cgtgaacggc tgcgtgaccg gacactttac 180 ttcggccgaa gacttaaacc tgttgattgc caaaaacacg agattagaga tctatgtggt 240 caccgccgag gggcttcggc ccgtcaaaga ggtgggcatg tatgggaaga ttgcggtcat 300 ggagcttttc aggcccaagg gggagagcaa ggacctgctg tttatcttga cagcgaagta 360 caatgcctgc atcctggagt ataaacagag tggcgagagc attgacatca ttacgcgagc 420 ccatggcaat gtccaggacc gcattggccg cccctcagag accggcatta ttggcatcat 480 tgaccctgag tgccggatga ttggcctgcg tctctatgat ggccttttca aggttattcc 540 actagatcgc gataataaag aactcaaggc cttcaacatc cgcctggagg agctgcatgt 600 cattgatgtc aagttcctat atggttgcca agcacctact atttgctttg tctaccagga 660 ccctcagggg cggcacgtaa aaacctatga ggtgtctctc cgagaaaagg aattcaataa 720 gggcccttgg aaacaggaaa atgtcgaagc tgaagcttcc atggtgatcg cagtcccaga 780 gccctttggg ggggccatca tcattggaca ggagtcaatc acctatcaca atggtgacaa 840 atacctggct attgcccctc ctatcatcaa gcaaagcacg attgtgtgcc acaatcgagt 900 ggaccctaat ggctcaagat acctgctggg agacatggaa ggccggctct tcatgctgct 960 tttggagaag gaggaacaga tggatggcac cgtcactctc aaggatctcc gtgtagaact 1020 ccttggagag acctctattg ctgagtgctt gacatacctt gataatggtg ttgtgtttgt 1080 cgggtctcgc ctgggtgact cccagcttgt gaagctcaac gttgacagta atgaacaagg 1140 ctcctatgta gtggccatgg aaacctttac caacttagga cccattgtcg atatgtgcgt 1200 ggtggacctg gagaggcagg ggcaggggca gctggtcact tgctctgggg ctttcaagga 1260 aggttctttg cggatcatcc ggaatggaat tggaatccac gagcatgcca gcattgactt 1320 accaggcatc aaaggattat ggccactgcg gtctgaccct aatcgtgaga cttatgacac 1380 tttggtgctc tcttttgtgg gccagacaag agttctcatg ttaaatggag aggaggtaga 1440 agaaaccgaa ctgatgggtt tcgtggatga tcagcagact ttcttctgtg gcaacgtggc 1500 tcatcagcag cttatccaga tcacttcagc atcggtgagg ttggtctctc aagaacccaa 1560 agctctggtc agtgaatgga aggagcctca ggccaagaac atcagtgtgg cctcctgcaa 1620 tagcagccag gtggtggtgg ctgtaggcag ggccctctac tatctgcaga tccatcctca 1680 ggagctccgg cagatcagcc acacagagat ggaacatgaa gtggcttgct tggacatcac 1740 cccattagga gacagcaatg gactgtcccc tctttgtgcc attggcctct ggacggacat 1800 ctcggctcgt atcttgaagt tgccctcttt tgaactactg cacaaggaga tgctgggtgg 1860 agagatcatt cctcgctcca tcctgatgac cacctttgag agtagccatt acctcctttg 1920 tgccttggga gatggagcgc ttttctactt tgggctcaac attgagacag gtctgttgag 1980 cgaccgtaag aaggtgactt tgggcaccca gcccaccgta ttgaggactt ttcgttctct 2040 ttctaccacc aacgtctttg cttgttctga ccgccccact gtcatctata gcagcaacca 2100 caaattggtc ttctcaaatg tcaacctcaa ggaagtgaac tacatgtgtc ccctcaattc 2160 agatggctat cctgacagcc tggcgctggc caacaatagc accctcacca ttggcaccat 2220 cgatgagatc cagaagctgc acattcgcac agttcccctc tatgagtctc caaggaagat 2280 ctgctaccag gaagtgtccc agtgtttcgg ggtcctctcc agccgcattg aagtccaaga 2340 cacgagtggg ggcacgacag ccttgaggcc cagcgctagc acccaggctc tgtccagcag 2400 tgtaagctcc agcaagctgt tctccagcag cactgctcct catgagacct cctttggaga 2460 agaggtggag gtgcataacc tacttatcat tgaccaacac acctttgaag tgcttcatgc 2520 ccaccagttt ctgcagaatg aatatgccct cagtctggtt tcctgcaagc tgggcaaaga 2580 ccccaacact tacttcattg tgggcacagc aatggtgtat cctgaagagg cagagcccaa 2640 gcagggtcgc attgtggtct ttcagtattc ggatggaaaa ctacagactg tggctgaaaa 2700 ggaagtgaaa ggggccgtgt actctatggt ggaatttaac gggaagctgt tagccagcat 2760 caatagcacg gtgcggctct atgagtggac aacagagaag gacgtgcgca ctgagtgcaa 2820 ccactacaac aacatcatgg ccctctacct gaagaccaag ggcgacttca tcctggtggg 2880 cgaccttatg cgctcagtgc tgctgcttgc ctacaagccc atggaaggaa actttgaaga 2940 gattgctcga gactttaatc ccaactggat gagtgctgtg gaaatcttgg atgatgacaa 3000 ttttctgggg gctgaaaatg cctttaactt gtttgtgtgt caaaaggata gcgctgccac 3060 cactgacgag gagcggcagc acctccagga ggttggtctt ttccacctgg gcgagtttgt 3120 caatgtcttt tgccacggct ctctggtaat gcagaatctg ggtgagactt ccacccccac 3180 acaaggctcg gtgctcttcg gcacggtcaa cggcatgata gggctggtga cctcactgtc 3240 agagagctgg tacaacctcc tgctggacat gcagaatcga ctcaataaag tcatcaaaag 3300 tgtggggaag atcgagcact ccttctggag atcctttcac accgagcgga agacagaacc 3360 agccacaggt ttcatcgacg gtgacttgat tgagagtttc ctggatatta gccgccccaa 3420 gatgcaggag gtggtggcaa acctacagta tgacgatggc agcggtatga agcgagaggc 3480 cactgcagac gacctcatca aggttgtgga ggagctaact cggatccatt agccaagggc 3540 agggggcccc tttgctgacc ctccccaaag gctttgccct gctgccctcc ccctcctctc 3600 caccatcgtc ttcttggcca tgggaggcct ttccctaagc cagctgcccc cagagccaca 3660 gttcccctat gtggaagtgg ggcgggcttc atagagactt gggaatgagc tgaaggtgaa 3720 acattttctc cctggatttt taccagtctc acatgattcc agccatcacc ttagaccacc 3780 aagccttgat tggtgttgcc agttgtcctc cttccgggga aggattttgc agttctttgg 3840 ctgaaaggaa gctgtgcgtg tgtgtgtgtg tatgtgtgtg tgtgtatgtg tatctcacac 3900 tcatgcattg tcctcttttt atttagattg gcagtgtagg gagttgtggg tagtggggaa 3960 gagggttagg agggtttcat tgtctgtgaa gtgagacctt ccttttactt ttcttctatt 4020 gcctctgaga gcatcaggcc tagaggcctg actgccaagc catgggtagc ctgggtgtaa 4080 aacctggaga tggtggatga tccccacgcc acagcccttt tgtctctgca aactgccttc 4140 ttcggaaaga agaaggtggg aggatgtgaa ttgttagttt ctgagtttta ccaaataaag 4200 tagaatataa gaagaaaaaa a 4221 <210> 390 <211> 4257 <212> DNA <213> Homo sapiens <400> 390 ggcctgcaac gtgtctctgg ggcggaggca gcggcagtgg agttcgctgc gcgctgttgg 60 gggccacctg tcttttcgct tgtgtccctc tttctagtgt cgcgctcgag tcccgacggg 120 ccgctccaag cctcgacatg tcgtacaact acgtggtaac ggcccagaag cccaccgccg 180 tgaacggctg cgtgaccgga cactttactt cggccgaaga cttaaacctg ttgattgcca 240 aaaacacgag attagagatc tatgtggtca ccgccgaggg gcttcggccc gtcaaagagg 300 tgggcatgta tgggaagatt gcggtcatgg agcttttcag gcccaagggg gagagcaagg 360 acctgctgtt tatcttgaca gcgaagtaca atgcctgcat cctggagtat aaacagagtg 420 gcgagagcat tgacatcatt acgcgagccc atggcaatgt ccaggaccgc attggccgcc 480 cctcagagac cggcattatt ggcatcattg accctgagtg ccggatgatt ggcctgcgtc 540 tctatgatgg ccttttcaag gttattccac tagatcgcga taataaagaa ctcaaggcct 600 tcaacatccg cctggaggag ctgcatgtca ttgatgtcaa gttcctatat ggttgccaag 660 cacctactat ttgctttgtc taccaggacc ctcaggggcg gcacgtaaaa acctatgagg 720 tgtctctccg agaaaaggaa ttcaataagg gcccttggaa acaggaaaat gtcgaagctg 780 aagcttccat ggtgatcgca gtcccagagc cctttggggg ggccatcatc attggacagg 840 agtcaatcac ctatcacaat ggtgacaaat acctggctat tgcccctcct atcatcaagc 900 aaagcacgat tgtgtgccac aatcgagtgg accctaatgg ctcaagatac ctgctgggag 960 acatggaagg ccggctcttc atgctgcttt tggagaagga ggaacagatg gatggcaccg 1020 tcactctcaa ggatctccgt gtagaactcc ttggagagac ctctattgct gagtgcttga 1080 cataccttga taatggtgtt gtgtttgtcg ggtctcgcct gggtgactcc cagcttgtga 1140 agctcaacgt tgacagtaat gaacaaggct cctatgtagt ggccatggaa acctttacca 1200 acttaggacc cattgtcgat atgtgcgtgg tggacctgga gaggcagggg caggggcagc 1260 tggtcacttg ctctggggct ttcaaggaag gttctttgcg gatcatccgg aatggaattg 1320 gaatccacga gcatgccagc attgacttac caggcatcaa aggattatgg ccactgcggt 1380 ctgaccctaa tcgtgagact gatgacactt tggtgctctc ttttgtgggc cagacaagag 1440 ttctcatgtt aaatggagag gaggtagaag aaaccgaact gatgggtttc gtggatgatc 1500 agcagacttt cttctgtggc aacgtggctc atcagcagct tatccagatc acttcagcat 1560 cggtgaggtt ggtctctcaa gaacccaaag ctctggtcag tgaatggaag gagcctcagg 1620 ccaagaacat cagtgtggcc tcctgcaata gcagccaggt ggtggtggct gtaggcaggg 1680 ccctctacta tctgcagatc catcctcagg agctccggca gatcagccac acagagatgg 1740 aacatgaagt ggcttgcttg gacatcaccc cattaggaga cagcaatgga ctgtcccctc 1800 tttgtgccat tggcctctgg acggacatct cggctcgtat cttgaagttg ccctcttttg 1860 aactactgca caaggagatg ctgggtggag agatcattcc tcgctccatc ctgatgacca 1920 cctttgagag tagccattac ctcctttgtg ccttgggaga tggagcgctt ttctactttg 1980 ggctcaacat tgagacaggt ctgttgagcg accgtaagaa ggtgactttg ggcacccagc 2040 ccaccgtatt gaggactttt cgttctcttt ctaccaccaa cgtctttgct tgttctgacc 2100 gccccactgt catctatagc agcaaccaca aattggtctt ctcaaatgtc aacctcaagg 2160 aagtgaacta catgtgtccc ctcaattcag atggctatcc tgacagcctg gcgctggcca 2220 acaatagcac cctcaccatt ggcaccatcg atgagatcca gaagctgcac attcgcacag 2280 ttcccctcta tgagtctcca aggaagatct gctaccagga agtgtcccag tgtttcgggg 2340 tcctctccag ccgcattgaa gtccaagaca cgagtggggg cacgacagcc ttgaggccca 2400 gcgctagcac ccaggctctg tccagcagtg taagctccag caagctgttc tccagcagca 2460 ctgctcctca tgagacctcc tttggagaag aggtggaggt gcacaaccta cttatcattg 2520 accaacacac ctttgaagtg cttcatgccc accagtttct gcagaatgaa tatgccctca 2580 gtctggtttc ctgcaagctg ggcaaagacc ccaacactta cttcattgtg ggcacagcaa 2640 tggtgtatcc tgaagaggca gagcccaagc agggtcgcat tgtggtcttt cagtattcgg 2700 atggaaaact acagactgtg gctgaaaagg aagtgaaagg ggccgtgtac tctatggtgg 2760 aatttaacgg gaagctgtta gccagcatca atagcacggt gcggctctat gagtggacaa 2820 cagagaagga gctgcgcact gagtgcaacc actacaacaa catcatggcc ctctacctga 2880 agaccaaggg cgacttcatc ctggtgggcg accttatgcg ctcagtgctg ctgcttgcct 2940 acaagcccat ggaaggaaac tttgaagaga ttgctcgaga ctttaatccc aactggatga 3000 gtgctgtgga aatcttggat gatgacaatt ttctgggggc tgaaaatgcc tttaacttgt 3060 ttgtgtgtca aaaggatagc gctgccacca ctgacgagga gcggcagcac ctccaggagg 3120 ttggtctttt ccacctgggc gagtttgtca atgtcttttg ccacggctct ctggtaatgc 3180 agaatctggg tgagacttcc acccccacac aaggctcggt gctcttcggc acggtcaacg 3240 gcatgatagg gctggtgacc tcactgtcag agagctggta caacctcctg ctggacatgc 3300 agaatcgact caataaagtc atcaaaagtg tggggaagat cgagcactcc ttctggagat 3360 cctttcacac cgagcggaag acagaaccag ccacaggttt catcgacggt gacttgattg 3420 agagtttcct ggatattagc cgccccaaga tgcaggaggt ggtggcaaac ctacagtatg 3480 acgatggcag cggtatgaag cgagaggcca ctgcagacga cctcatcaag gttgtggagg 3540 agctaactcg gatccattag ccaagggcag ggggcccctt tgctgaccct ccccaaaggc 3600 tttgccctgc tgccctcccc ctcctctcca ccatcgtctt cttggccatg ggaggccttt 3660 ccctaagcca gctgccccca gagccacagt tcccctatgt ggaagtgggg cgggcttcat 3720 agagacttgg gaatgagctg aaggtgaaac attttctccc tggattttta ccagtctcac 3780 atgattccag ccatcacctt agaccaccaa gccttgattg gtgttgccag ttgtcctcct 3840 tccggggaag gattttgcag ttctttggct gaaaggaagc tgtgcgtgtg tgtgtgtgta 3900 tgtgtgtgtg tgtatgtgta tctcacactc atgcattgtc ctctttttat ttagattggc 3960 agtgtaggga gttgtgggta gtggggaaga gggttaggag ggtttcattg tctgtgaagt 4020 gagaccttcc ttttactttt cttctattgc ctctgagagc atcaggccta gaggcctgac 4080 tgccaagcca tgggtagcct gggtgtaaaa cctggagatg gtggatgatc cccacgccac 4140 agcccttttg tctctgcaaa ctgccttctt cggaaagaag aaggtgggag gatgtgaatt 4200 gttagtttct gagttttacc aaataaagta gaatataaga aaaaaaaaaa aaaaaaa 4257 <210> 391 <211> 4196 <212> DNA <213> Homo sapiens <400> 391 cacctgtctt ttcgcttgtg tccctctttc tagtgtcgcg ctcgagtccc gacgggccgc 60 tccaagcctc gacatgtcgt acaactacgt ggtaacggcc cagaagccca ccgccgtgaa 120 cggctgcgtg accggacact ttacttcggc cgaagactta aacctgttga ttgccaaaaa 180 cacgagatta gagatctatg tggtcaccgc cgaggggctt cggcccgtca aagaggtggg 240 catgtatggg aagattgcgg tcatggagct tttcaggccc aagggggaga gcaaggacct 300 gctgtttatc ttgacagcga agtacaatgc ctgcatcctg gagtataaac agagtggcga 360 gagcattgac atcattacgc gagcccatgg caatgtccag gaccgcattg gccgcccctc 420 agagaccggc attattggca tcattgaccc tgagtgccgg atgattggcc tgcgtctcta 480 tgatggcctt ttcaaggtta ttccactaga tcgcgataat aaagaactca aggccttcaa 540 catccgcctg gaggagctgc atgtcattga tgtcaagttc ctatatggtt gccaagcacc 600 tactatttgc tttgtctacc aggaccctca ggggcggcac gtaaaaacct atgaggtgtc 660 tctccgagaa aaggaattca ataagggccc ttggaaacag gaaaatgtcg aagctgaagc 720 ttccatggtg atcgcagtcc cagagccctt tgggggggcc atcatcattg gacaggagtc 780 aatcacctat cacaatggtg acaaatacct ggctattgcc cctcctatca tcaagcaaag 840 cacgattgtg tgccacaatc gagtggaccc taatggctca agatacctgc tgggagacat 900 ggaaggccgg ctcttcatgc tgcttttgga gaaggaggaa cagatggatg gcaccgtcac 960 tctcaaggat ctccgtgtag aactccttgg agagacctct attgctgagt gcttgacata 1020 ccttgataat ggtgttgtgt ttgtcgggtc tcgcctgggt gactcccagc ttgtgaagct 1080 caacgttgac agtaatgaac aaggctccta tgtagtggcc atggaaacct ttaccaactt 1140 aggacccatt gtcgatatgt gcgtggtgga cctggagagg caggggcagg ggcagctggt 1200 cacttgctct ggggctttca aggaaggttc tttgcggatc atccggaatg gaattggaat 1260 ccacgagcat gccagcattg acttaccagg catcaaagga ttatggccac tgcggtctga 1320 ccctaatcgt gagactgatg acactttggt gctctctttt gtgggccaga caagagttct 1380 catgttaaat ggagaggagg tagaagaaac cgaactgatg ggtttcgtgg atgatcagca 1440 gactttcttc tgtggcaacg tggctcatca gcagcttatc cagatcactt cagcatcggt 1500 gaggttggtc tctcaagaac ccaaagctct ggtcagtgaa tggaaggagc ctcaggccaa 1560 gaacatcagt gtggcctcct gcaatagcag ccaggtggtg gtggctgtag gcagggccct 1620 ctactatctg cagatccatc ctcaggagct ccggcagatc agccacacag agatggaaca 1680 tgaagtggct tgcttggaca tcaccccatt aggagacagc aatggactgt cccctctttg 1740 tgccattggc ctctggacgg acatctcggc tcgtatcttg aagttgccct cttttgaact 1800 actgcacaag gagatgctgg gtggagagat cattcctcgc tccatcctga tgaccacctt 1860 tgagagtagc cattacctcc tttgtgcctt gggagatgga gcgcttttct actttgggct 1920 caacattgag acaggtctgt tgagcgaccg taagaaggtg actttgggca cccagcccac 1980 cgtattgagg acttttcgtt ctctttctac caccaacgtc tttgcttgtt ctgaccgccc 2040 cactgtcatc tatagcagca accacaaatt ggtcttctca aatgtcaacc tcaaggaagt 2100 gaactacatg tgtcccctca attcagatgg ctatcctgac agcctggcgc tggccaacaa 2160 tagcaccctc accattggca ccatcgatga gatccagaag ctgcacattc gcacagttcc 2220 cctctatgag tctccaagga agatctgcta ccaggaagtg tcccagtgtt tcggggtcct 2280 ctccagccgc attgaagtcc aagacacgag tgggggcacg acagccttga ggcccagcgc 2340 tagcacccag gctctgtcca gcagtgtaag ctccagcaag ctgttctcca gcagcactgc 2400 tcctcatgag acctcctttg gagaagaggt ggaggtgcac aacctactta tcattgacca 2460 acacaccttt gaagtgcttc atgcccacca gtttctgcag aatgaatatg ccctcagtct 2520 ggtttcctgc aagctgggca aagaccccaa cacttacttc attgtgggca cagcaatggt 2580 gtatcctgaa gaggcagagc ccaagcaggg tcgcattgtg gtctttcagt attcggatgg 2640 aaaactacag actgtggctg aaaaggaagt gaaaggggcc gtgtactcta tggtggaatt 2700 taacgggaag ctgttagcca gcatcaatag cacggtgcgg ctctatgagt ggacaacaga 2760 gaaggagctg cgcactgagt gcaaccacta caacaacatc atggccctct acctgaagac 2820 caagggcgac ttcatcctgg tgggcgacct tatgcgctca gtgctgctgc ttgcctacaa 2880 gcccatggaa ggaaactttg aagagattgc tcgagacttt aatcccaact ggatgagtgc 2940 tgtggaaatc ttggatgatg acaattttct gggggctgaa aatgccttta acttgtttgt 3000 gtgtcaaaag gatagcgctg ccaccactga cgaggagcgg cagcacctcc aggaggttgg 3060 tcttttccac ctgggcgagt ttgtcaatgt cttttgccac ggctctctgg taatgcagaa 3120 tctgggtgag acttccaccc ccacacaagg ctcggtgctc ttcggcacgg tcaacggcat 3180 gatagggctg gtgacctcac tgtcagagag ctggtacaac ctcctgctgg acatgcagaa 3240 tcgactcaat aaagtcatca aaagtgtggg gaagatcgag cactccttct ggagatcctt 3300 tcacaccgag cggaagacag aaccagccac aggtttcatc gacggtgact tgattgagag 3360 tttcctggat attagccgcc ccaagatgca ggaggtggtg gcaaacctac agtatgacga 3420 tggcagcggt atgaagcgag aggccactgc agacgacctc atcaaggttg tggaggagct 3480 aactcggatc cattagccaa gggcaggggg cccctttgct gaccctcccc aaaggctttg 3540 ccctgctgcc ctccccctcc tctccaccat cgtcttcttg gccatgggag gcctttccct 3600 aagccagctg cccccagagc cacagttccc ctatgtggaa gtggggcggg cttcatagag 3660 acttgggaat gagctgaagg tgaaacattt tctccctgga tttttaccag tctcacatga 3720 ttccagccat caccttagac caccaagcct tgattggtgt tgccagttgt cctccttccg 3780 gggaaggatt ttgcagttct ttggctgaaa ggaagctgtg cgtgtgtgtg tgtttatgtg 3840 tgtgtgtgta tgtgtatctc acactcatgc attgtcctct ttttatttag attggcagtg 3900 tagggagttg tgggtagtgg ggaagagggt taggagggtt tcattgtctg tgaagtgaga 3960 ccttcctttt acttttcttc tattgcctct gagagcatca ggcctagagg cctgactgcc 4020 aagccatggg tagcctgggt gtaaaacctg gagatggtgg atgatcccca cgccacagcc 4080 cttttgtctc tgcaaactgc cttcttcgga aagaagaagg tgggaggatg tgaattgtta 4140 gtttctgagt tttaccaaat aaagtagaat ataagaagaa aaaaaaaaaa aaaaaa 4196 <210> 392 <211> 4241 <212> DNA <213> Homo sapiens <400> 392 gtgtctctgg ggcggaggca gcggcagtgg agttcgctgc gcgctgttgg gggccacctg 60 tcttttcgct tgtgtccctc tttctagtgt cgcgctcgag tcccgacggg ccgctccaag 120 cctcgacatg tcgtacaact acgtggtaac ggcccagaag cccaccgccg tgaacggctg 180 cgtgaccgga cactttactt cggccgaaga cttaaacctg ttgattgcca aaaacacgag 240 attagagatc tatgtggtca ccgccgaggg gcttcggccc gtcaaagagg tgggcatgta 300 tgggaagatt gcggtcatgg agcttttcag gcccaagggg gagagcaagg acctgctgtt 360 tatcttgaca gcgaagtaca atgcctgcat cctggagtat aaacagagtg gcgagagcat 420 tgacatcatt acgcgagccc atggcaatgt ccaggaccgc attggccgcc cctcagagac 480 cggcattatt ggcatcattg accctgagtg ccggatgatt ggcctgcgtc tctatgatgg 540 ccttttcaag gttattccac tagatcgcga taataaagaa ctcaaggcct tcaacatccg 600 cctggaggag ctgcatgtca ttgatgtcaa gttcctatat ggttgccaag cacctactat 660 ttgctttgtc taccaggacc ctcaggggcg gcacgtaaaa acctatgagg tgtctctccg 720 agaaaaggaa ttcaataagg gcccttggaa acaggaaaat gtcgaagctg aagcttccat 780 ggtgatcgca gtcccagagc cctttggggg ggccatcatc attggacagg agtcaatcac 840 ctatcacaat ggtgacaaat acctggctat tgcccctcct atcatcaagc aaagcacgat 900 tgtgtgccac aatcgagtgg accctaatgg ctcaagatac ctgctgggag acatggaagg 960 ccggctcttc atgctgcttt tggagaagga ggaacagatg gatggcaccg tcactctcaa 1020 ggatctccgt gtagaactcc ttggagagac ctctattgct gagtgcttga cataccttga 1080 taatggtgtt gtgtttgtcg ggtctcgcct gggtgactcc cagcttgtga agctcaacgt 1140 tgacagtaat gaacaaggct cctatgtagt ggccatggaa acctttacca acttaggacc 1200 cattgtcgat atgtgcgtgg tggacctgga gaggcagggg caggggcagc tggtcacttg 1260 ctctggggct ttcaaggaag gttctttgcg gatcatccgg aatggaattg gaatccacga 1320 gcatgccagc attgacttac caggcatcaa aggattatgg ccactgcggt ctgaccctaa 1380 tcgtgagact gatgacactt tggtgctctc ttttgtgggc cagacaagag ttctcatgtt 1440 aaatggagag gaggtagaag aaaccgaact gatgggtttc gtggatgatc agcagacttt 1500 cttctgtggc aacgtggctc atcagcagct tatccagatc acttcagcat cggtgaggtt 1560 ggtctctcaa gaacccaaag ctctggtcag tgaatggaag gagcctcagg ccaagaacat 1620 cagtgtggcc tcctgcaata gcagccaggt ggtggtggct gtaggcaggg ccctctacta 1680 tctgcagatc catcctcagg agctccggca gatcagccac acagagatgg aacatgaagt 1740 ggcttgcttg gacatcaccc cattaggaga cagcaatgga ctgtcccctc tttgtgccat 1800 tggcctctgg acggacatct cggctcgtat cttgaagttg ccctcttttg aactactgca 1860 caaggagatg ctgggtggag agatcattcc tcgctccatc ctgatgacca cctttgagag 1920 tagccattac ctcctttgtg ccttgggaga tggagcgctt ttctactttg ggctcaacat 1980 tgagacaggt ctgttgagcg accgtaagaa ggtgactttg ggcacccagc ccaccgtatt 2040 gaggactttt cgttctcttt ctaccaccaa cgtctttgct tgttctgacc gccccactgt 2100 catctatagc agcaaccaca aattggtctt ctcaaatgtc aacctcaagg aagtgaacta 2160 catgtgtccc ctcaattcag atggctatcc tgacagcctg gcgctggcca acaatagcac 2220 cctcaccatt ggcaccatcg atgagatcca gaagctgcac attcgcacag ttcccctcta 2280 tgagtctcca aggaagatct gctaccagga agtgtcccag tgtttcgggg tcctctccag 2340 ccgcattgaa gtccaagaca cgagtggggg cacgacagcc ttgaggccca gcgctagcac 2400 ccaggctctg tccagcagtg taagctccag caagctgttc tccagcagca ctgctcctca 2460 tgagacctcc tttggagaag aggtggaggt gcacaaccta cttatcattg accaacacac 2520 ctttgaagtg cttcatgccc accagtttct gcagaatgaa tatgccctca gtctggtttc 2580 ctgcaagctg ggcaaagacc ccaacactta cttcattgtg ggcacagcaa tggtgtatcc 2640 tgaagaggca gagcccaagc agggtcgcat tgtggtcttt cagtattcgg atggaaaact 2700 acagactgtg gctgaaaagg aagtgaaagg ggccgtgtac tctatggtgg aatttaacgg 2760 gaagctgtta gccagcatca atagcacggt gcggctctat gagtggacaa cagagaagga 2820 gctgcgcact gagtgcaacc actacaacaa catcatggcc ctctacctga agaccaaggg 2880 cgacttcatc ctggtgggcg accttatgcg ctcagtgctg ctgcttgcct acaagcccat 2940 ggaaggaaac tttgaagaga ttgctcgaga ctttaatccc aactggatga gtgctgtgga 3000 aatcttggat gatgacaatt ttctgggggc tgaaaatgcc tttaacttgt ttgtgtgtca 3060 aaaggatagc gctgccacca ctgacgagga gcggcagcac ctccaggagg ttggtctttt 3120 ccacctgggc gagtttgtca atgtcttttg ccacggctct ctggtaatgc agaatctggg 3180 tgagacttcc acccccacac aaggctcggt gctcttcggc acggtcaacg gcatgatagg 3240 gctggtgacc tcactgtcag agagctggta caacctcctg ctggacatgc agaatcgact 3300 caataaagtc atcaaaagtg tggggaagat cgagcactcc ttctggagat cctttcacac 3360 cgagcggaag acagaaccag ccacaggttt catcgacggt gacttgattg agagtttcct 3420 ggatattagc cgccccaaga tgcaggaggt ggtggcaaac ctacagtatg acgatggcag 3480 cggtatgaag cgagaggcca ctgcagacga cctcatcaag gttgtggagg agctaactcg 3540 gatccattag ccaagggcag ggggcccctt tgctgaccct ccccaaaggc tttgccctgc 3600 tgccctcccc ctcctctcca ccatcgtctt cttggccatg ggaggccttt ccctaagcca 3660 gctgccccca gagccacagt tcccctatgt ggaagtgggg cgggcttcat agagacttgg 3720 gaatgagctg aaggtgaaac attttctccc tggattttta ccagtctcac atgattccag 3780 ccatcacctt agaccaccaa gccttgattg gtgttgccag ttgtcctcct tccggggaag 3840 gattttgcag ttctttggct gaaaggaagc tgtgcgtgtg tgtgtgtgta tgtgtgtgtg 3900 tgtatgtgta tctcacactc atgcattgtc ctctttttat ttagattggc agtgtaggga 3960 gttgtgggta gtggggaaga gggttaggag ggtttcattg tctgtgaagt gagaccttcc 4020 ttttactttt cttctattgc ctctgagagc atcaggccta gaggcctgac tgccaagcca 4080 tgggtagcct gggtgtaaaa cctggagatg gtggatgatc cccacgccac agcccttttg 4140 tctctgcaaa ctgccttctt cggaaagaag aaggtgggag gatgtgaatt gttagtttct 4200 gagttttacc aaataaagta gaatataaaa aaaaaaaaaa a 4241 <210> 393 <211> 4193 <212> DNA <213> Homo sapiens <400> 393 gtggagttcg ctgcggctgt tgggggccac ctgtcttttc gcttgtgccc ctctttctag 60 tgtcgcgctc gagtcccgac gggccgctcc aagcctcgac atgtcgtaca actacgtggt 120 aacggcccag aagcccaccg ccgtgaacgg ctgcgtgacc ggacacttta cttcggccga 180 agacttaaac ctgttgattg ccaaaaacac gagattagag atctatgtgg tcaccgccga 240 ggggcttcgg cccgtcaaag aggtgggcat gtatgggaag attgcggtca tggagctttt 300 caggcccaag ggggagagca aggacctgct gtttatcttg acagcgaagt acaatgcctg 360 catcctggag tataaacaga gtggcgagag cattgacatc attacgcgag cccatggcaa 420 tgtccaggac cgcattggcc gcccctcaga gaccggcatt attggcatca ttgaccctga 480 gtgccggatg attggcctgc gtctctatga tggccttttc aaggttattc cactagatcg 540 cgataataaa gaactcaagg ccttcaacat ccgcctggag gagctgcatg tcattgatgt 600 caagttccta tatggttgcc aagcacctac tatttgcttt gtctaccagg accctcaggg 660 gcggcacgta aaaacctatg aggtgtctct ccgagaaaag gaattcaata agggcccttg 720 gaaacaggaa aatgtcgaag ctgaagcttc catggtgatc gcagtcccag agccctttgg 780 gggggccatc atcattggac aggagtcaat cacctatcac aatggtgaca aatacctggc 840 tattgcccct cctatcatca agcaaagcac gattgtgtgc cacaatcgag tggaccctaa 900 tggctcaaga tacctgctgg gagacatgga aggccggctc ttcatgctgc ttttggagaa 960 ggaggaacag atggatggca ccgtcactct caaggatctc cgtgtagaac tccttggaga 1020 gacctctatt gctgagtgct tgacatacct tgataatggt gttgtgtttg tcgggtctcg 1080 cctgggtgac tcccagcttg tgaagctcaa cgttgacagt aatgaacaag gctcctatgt 1140 agtggccatg gaaaccttta ccaacttagg acccattgtc gatatgtgcg tggtggacct 1200 ggagaggcag gggcaggggc agctggtcac ttgctctggg gctttcaagg aaggttcttt 1260 gcggatcatc cggaatggaa ttggaatcca cgagcatgcc agcattgact taccaggcat 1320 caaaggatta tggccactgc ggtctgaccc taatcgtgag actgatgaca ctttggtgct 1380 ctcttttgtg ggccagacaa gagttctcat gttaaatgga gaggaggtag aagaaaccga 1440 actgatgggt ttcgtggatg atcagcagac tttcttctgt ggcaacgtgg ctcatcagca 1500 gcttatccag atcacttcag catcggtgag gttggtctct caagaaccca aagctctggt 1560 cagtgaatgg aaggagcctc aggccaagaa catcagtgtg gcctcctgca atagcagcca 1620 ggtggtggtg gctgtaggca gggccctcta ctatctgcag atccatcctc aggagctccg 1680 gcagatcagc cacacagaga tggaacatga agtggcttgc ttggacatca ccccattagg 1740 agacagcaat ggactgtccc ctctttgtgc cattggcctc tggacggaca tctcggctcg 1800 tatcttgaag ttgccctctt ttgaactact gcacaaggag atgctgggtg gagagatcat 1860 tcctcgctcc atcctgatga ccacctttga gagtagccat tacctccttt gtgccttggg 1920 agatggagcg cttttctact ttgggctcaa cattgagaca ggtctgttga gcgaccgtaa 1980 gaaggtgact ttgggcaccc agcccaccgt attgaggact tttcgttctc tttctaccac 2040 caacgtcttt gcttgttctg accgccccac tgtcatctat agcagcaacc acaaattggt 2100 cttctcaaat gtcaacctca aggaagtgaa ctacatgtgt cccctcaatt cagatggcta 2160 tcctgacagc ctggcgctgg ccaacaatag caccctcacc attggcacca tcgatgagat 2220 ccagaagctg cacattcgca cagttcccct ctatgagtct ccaaggaaga tctgctacca 2280 ggaagtgtcc cagtgtttcg gggtcctctc cagccgcatt gaagtccaag acacgagtgg 2340 gggcacgaca gccttgaggc ccagcgctag cacccaggct ctgtccagca gtgtaagctc 2400 cagcaagctg ttctccagca gcactgctcc tcatgagacc tcctttggag aagaggtgga 2460 ggtgcacaac ctacttatca ttgaccaaca cacctttgaa gtgcttcatg cccaccagtt 2520 tctgcagaat gaatatgccc tcagtctggt ttcctgcaag ctgggcaaag accccaacac 2580 ttacttcatt gtgggcacag caatggtgta tcctgaagag gcagagccca agcagggtcg 2640 cattgtggtc tttcagtatt cggatggaaa actacagact gtggctgaaa aggaagtgaa 2700 aggggccgtg tactctatgg tggaatttaa cgggaagctg ttagccagca tcaatagcac 2760 ggtgcggctc tatgagtgga caacagagaa ggagctgcgc actgagtgca accactacaa 2820 caacatcatg gccctctacc tgaagaccaa gggcgacttc atcctggtgg gcgaccttat 2880 gcgctcagtg ctgctgcttg cctacaagcc catggaagga aactttgaag agattgctcg 2940 agactttaat cccaactgga tgagtgctgt ggaaatcttg gatgatgaca attttctggg 3000 ggctgaaaat gcctttaact tgtttgtgtg tcaaaaggat agcgctgcca ccactgacga 3060 ggagcggcag cacctccagg aggttggtct tttccacctg ggcgagtttg tcaatgtctt 3120 ttgccacggc tctctggtaa tgcagaatct gggtgagact tccaccccca cacaaggctc 3180 ggtgctcttc ggcacggtca acggcatgat agggctggtg acctcactgt cagagagctg 3240 gtacaacctc ctgctggaca tgcagaatcg actcaataaa gtcatcaaaa gtgtggggaa 3300 gatcgagcac tccttctgga gatcctttca caccgagcgg aagacagaac cagccacagg 3360 tttcatcgac ggtgacttga ttgagagttt cctggatatt agccgcccca agatgcagga 3420 ggtggtggca aacctacagt atgacgatgg cagcggtatg aagcgagagg ccactgcaga 3480 cgacctcatc aaggttgtgg aggagctaac tcggatccat tagccaaggg cagggggccc 3540 cctttctgac cctccccaaa ggctttgccc tgctgccctc cccctcctct ccaccatcgt 3600 cttcttggcc atgggaggcc tttccctaag ccagctgccc ccagagccac agttccccta 3660 tgtggaagtg gggcgggctt catagagact tgggaatgag ctgaaggtga aacattttct 3720 ccctggattt ttaccagtct cacatgattc cagccatcac cttagaccac caagccttga 3780 ttggtgttgc cagttgtcct ccttccgggg aaggattttg cagttctttg gctgaaagga 3840 agctgtgcgt gtgtgtgtgt gtatgtgtgt gtgtgtatgt gtatctcaca ctcatgcaat 3900 gtcctctttt tatttagatt ggcagtgtag ggagttgtgg gtagtgggga agagggttag 3960 gagggtttca ttgtctgtga agtgagacct tccttttact tttcttctat tgcctctgag 4020 agcatcagcc tagaggcctg actgccaagc catgggtagc ctgggtgtaa aacctggaga 4080 tggtggatga tccccacgcc acagcccttt tgtctctgca aactgccttc ttcggaaaga 4140 agaaggtggg aggatgtgaa ttgttagttt ctgagtttta ccaaataaag tag 4193 <210> 394 <211> 3723 <212> DNA <213> Homo sapiens <400> 394 cagcggcagt ggagttcgct gcgcgctgtt gggggccacc tgtcttttcg cttgtgtccc 60 tctttctagt gtcgcgctcg agtcccgacg ggccgctcca agcctcgaca tgtcgtacaa 120 ctacgtggta acggcccaga agcccaccgc cgtgaacggc tgcgtgaccg gacactttac 180 ttcggccgaa gacttaaacc tgttgattgc caaaaacacg agattagaga tctatgtggt 240 caccgccgag gggcttcggc ccgtcaaaga ggtgggcatg tatgggaaga ttgcggtcat 300 ggagcttttc aggcccaagg gggagagcaa ggacctgctg tttatcttga cagcgaagta 360 caatgcctgc atcctggagt ataaacagag tggcgagagc attgatatca ttacgcgagc 420 ccatggcaat gtccaggacc gcattggccg cccctcagag accggcatta ttggcatcat 480 tgaccctgag tgccggatga ttggcctgcg tctctatgat ggccttttca aggttattcc 540 actagatcgc gataataaag aactcaaggc cttcaacatc cgcctggagg agctgcatgt 600 cattgatgtc aagttcctat atggttgcca agcacctact atttgctttg tctaccagga 660 ccctcagggg cggcacgtaa aaacctatga ggtgtctctc cgagaaaagg aattcaataa 720 gggcccttgg aaacaggaaa atgtcgaagc tgaagcttcc atggtgatcg cagtcccaga 780 gccctttggg ggggccatca tcattggaca ggagtcaatc acctatcaca atggtgacaa 840 atacctggct attgcccctc ctatcatcaa gcaaagcacg attgtgtgcc acaatcgagt 900 ggaccctaat ggctcaagat acctgctggg agacatggaa ggccggctct tcatgctgct 960 tttggagaag gaggaacaga tggatggcac cgtcactctc aaggatctcc gtgtagaact 1020 ccttggagag acctctattg ctgagtgctt gacatacctt gataatggtg ttgtgtttgt 1080 cgggtctcgc ctgggtgact cccagcttgt gaagctcaac gttgacagta atgaacaagg 1140 ctcctatgta gtggccatgg aaacctttac caacttagga cccattgtcg atatgtgcgt 1200 ggtggacctg gagaggcagg ggcaggggca gctggtcact tgctctgggg ctttcaagga 1260 aggttctttg cggatcatcc ggaatggaat tggaatccac gagcatgcca gcattgactt 1320 accaggcatc aaaggattat ggccactgcg gtctgaccct aatcgtgaga ctgatgacac 1380 tttggtgctc tcttttgtgg gccagacaag agttctcatg ttaaatggag aggaggtaga 1440 agaaaccgaa ctgatgggtt tcgtggatga tcagcagact ttcttctgtg gcaacgtggc 1500 tcatcagcag cttatccaga tcacttcagc atcggtgagg ttggtctctc aagaacccaa 1560 agctctggtc agtgaatgga aggagcctca ggccaagaac atcagtgtgg cctcctgcaa 1620 tagcagccag gtggtggtgg ctgtaggcag ggccctctac tatctgcaga tccatcctca 1680 ggagctccgg cagatcagcc acacagggat ggaacatgaa gtggcttgct tggacatcac 1740 cccattagga gacagcaatg gactgtcccc tctttgtgcc attggcctct ggacggacat 1800 ctcggctcgt atcttgaagt tgccctcttt tgaactactg cacaaggaga tgctgggtgg 1860 agagatcatt cctcgctcca tcctgatgac cacctttgag agtagccatt acctcctttg 1920 tgccttggga gatggagcgc ttttctactt tgggctcaac attgagacag gtctgttgag 1980 cgaccgtaag aaggtgactt tgggcaccca gcccaccgta ttgaggactt ttcgttctct 2040 ttctaccacc aacgtctttg cttgttctga ccgccccact gtcatctata gcagcaacca 2100 caaattggtc ttctcaaatg tcaacctcaa ggaagtgaac tacatgtgtc ccctcaattc 2160 agatggctat cctgacagcc tggcgctggc caacaatagc accctcacca ttggcaccat 2220 cgatgagatc cagaagctgc acattcgcac agttcccctc tatgagtctc caaggaagat 2280 ctgctaccag gaagtgtccc agtgtttcgg ggtcctctcc agccgcattg aagtccaaga 2340 cacgagtggg ggcacgacag ccttgaggcc cagcgctagc acccaggctc tgtccagcag 2400 tgtaagctcc agcaagctgt tctccagcag cactgctcct catgagacct cctttggaga 2460 agaggtggag gtgcataacc tacttatcat tgaccaacac acctttgaag tgcttcatgc 2520 ccaccagttt ctgcagaatg aatatgccct cagtctggtt tcctgcaagc tgggcaaaga 2580 ccccaacact tacttcattg tgggcacagc aatggtgtat cctgaagagg cagagcccaa 2640 gcagggtcgc attgtggtct ttcagtattc ggatggaaaa ctacagactg tggctgaaaa 2700 ggaagtgaaa ggggacgtgt actctatggt ggaatttaac gggaagctgt tagccagcat 2760 caatagcacg gtgcggctct atgagtggac aacagagaag gacgtgcgca ctgagtgcaa 2820 ccactacaac aacatcatgg ccctctacct gaagaccaag ggcgacttca tcctggtggg 2880 cgaccttatg cgctcagtgc tgctgcttgc ctacaagccc atggaaggaa actttgaaga 2940 gattgctcga gactttaatc ccaactggat gagtgctgtg gaaatcttgg atgatgacaa 3000 ttttctgggg gctgaaaatg cctttaactt gtttgtgtgt caaaaggata gcgctgccac 3060 cactgacgag gagcggcagc acctccagga ggttggtctt ttccacctgg gcgagtttgt 3120 caatgtcttt tgccacggct ctctggtaat gcagaatctg ggtgagactt ccacccccac 3180 acaaggctcg gtgctcttcg gcacggtcaa cggcatgata gggctggtga cctcactgtc 3240 agagagctgg tacaacctcc tgctggacat gcagaatcga ctcaataaag tcatcaaaag 3300 tgtggggaag atcgagcact ccttctggag atcctttcac accgagcgga agacagaacc 3360 agccacaggt ttcatcgacg gtgacttgat tgagagtttc ctggatatta gccgccccaa 3420 gatgcaggag gtggtggcaa acctacagta tgacgatggc agcggtatga agcgagaggc 3480 cactgcagac gacctcatca aggttgtgga ggagctaact cggatccatt agccaagggc 3540 agggggcccc tttgctgacc ctccccaaag gctttgccct gctgccctcc ccctcctctc 3600 caccatcgtc ttcttggcca tgggaggcct ttccctaagc cagctgcccc cagagccaca 3660 gttcccctat gtggaagtgg ggcgggcttc atagagactt gggaatgagc tgaaggtgaa 3720 aca 3723 <210> 395 <211> 4072 <212> DNA <213> Homo sapiens <400> 395 tcgcgctcga gtcccgacgg gccgctccaa gcctcgacat gtcgtacaac tacgtggtaa 60 cggcccagaa gcccaccgcc gtgaacggct gcgtgaccgg acactttact tcggccgaag 120 acttaaacct gttgattgcc aaaaacacga gattagagat ctatgtggtc accgccgagg 180 ggcttcggcc tgtcaaagag gtgggcatgt atgggaagat tgcggtcatg gagcttttca 240 ggcccaaggg ggagagcaag gacctgctgt ttatcttgac agcgaagtac aatgcctgca 300 tcctggagta taaacagagt ggcgagagca ttgacatcat tacgcgagcc catggcaatg 360 tccaggaccg cattggccgc ccctcagaga ccggcattat tggcatcatt gaccctgagt 420 gccggatgat tggcctgcgt ctctatgatg gccttttcaa ggttattcca ctagatcgcg 480 ataataaaga actcaaggcc ttcaacatcc gcctggagga gctgcatgtc attgatgtca 540 agttcctata tggttgccaa gcacctacta tttgctttgt ctaccaggac cctcaggggc 600 ggcacgtaaa aacctatgag gtgtctctcc gagaaaagga attcaataag ggcccttgga 660 aacaggaaaa tgtcgaagct gaagcttcca tggtgatcgc agtcccagag ccctttgggg 720 gggccatcat cattggacag gagtcaatca cctatcacaa tggtgacaaa tacctggcta 780 ttgcccctcc tatcatcaag caaagcacga ttgtgtgcca caatcgagtg gaccctaatg 840 gctcaagata cctgctggga gacatggaag gccggctctt catgctgctt ttggagaagg 900 aggaacagat ggatggcacc gtcactctca aggatctccg tgtagaactc cttggagaga 960 cctctattgc tgagtgcttg acataccttg ataatggtgt tgtgtttgtc gggtctcgcc 1020 tgggtgactc ccagcttgtg aagctcaacg ttgacagtaa tgaacaaggc tcctatgtag 1080 tggccatgga aacctttacc aacttaggac ccattgtcga tatgtgcgtg gtggacctgg 1140 agaggcaggg gcaggggcag ctggtcactt gctctggggc tttcaaggaa ggttctttgc 1200 ggatcatccg gaatggaatt ggaatccacg agcatgccag cattgactta ccaggcatca 1260 aaggattatg gccactgcgg tctgacccta atcgtgagac tgatgacact ttggtgctct 1320 cttttgtggg ccagacaaga gttctcatgt taaatggaga ggaggtagaa gaaaccgaac 1380 tgatgggttt cgtggatgat cagcagactt tcttctgtgg caacgtggct catcagcagc 1440 ttatccagat cacttcagca tcggtgaggt tggtctctca agaacccaaa gctctggtca 1500 gtgaatggaa ggagcctcag gccaagaaca tcagtgtggc ctcctgcaat agcagccagg 1560 tggtggtggc tgtaggcagg gccctctact atctgcagat ccatcctcag gagctccggc 1620 agatcagcca cacagagatg gaacatgaag tggcttgctt ggacatcacc ccattaggag 1680 acagcaatgg actgtcccct ctttgtgcca ttggcctctg gacggacatc tcggctcgta 1740 tcttgaagtt gccctctttt gaactactgc acaaggagat gctgggtgga gagatcattc 1800 ctcgctccat cctgatgacc acctttgaga gtagccatta cctcctttgt gccttgggag 1860 atggagcgct tttctacttt gggctcaaca ttgagacagg tctgttgagc gaccgtaaga 1920 aggtgacttt gggcacccag cccaccgtat tgaggacttt tcgttctctt tctaccacca 1980 acgtctttgc ttgttctgac cgccccactg tcatctatag cagcaaccac aaattggtct 2040 tctcaaatgt caacctcaag gaagtgaact acatgtgtcc cctcaattca gatggctatc 2100 ctgacagcct ggcgctggcc aacaatagca ccctcaccat tggcaccatc gatgagatcc 2160 agaagctgca cattcgcaca gttcccctct atgagtctcc aaggaagatc tgctaccagg 2220 aagtgtccca gtgtttcggg gtcctctcca gccgcattga agtccaagac acgagtgggg 2280 gcacgacagc cttgaggccc agcgctagca cccaggctct gtccagcagt gtaagctcca 2340 gcaagctgtt ctccagcagc actgctcctc atgagacctc ctttggagaa gaggtggagg 2400 tgcacaacct acttatcatt gaccaacaca cctttgaagt gcttcatgcc caccagtttc 2460 tgcagaatga atatgccctc agtctggttt cctgcaagct gggcaaagac cccaacactt 2520 acttcattgt gggcacagca atggtgtatc ctgaagaggc agagcccaag cagggtcgca 2580 ttgtggtctt tcagtattcg gatggaaaac tacagactgt ggctgaaaag gaagtgaaag 2640 gggccgtgta ctctatggtg gaatttaacg ggaagctgtt agccagcatc aatagcacgg 2700 tgcggctcta tgagtggaca acagagaagg agctgcgcac tgagtgcaac cactacaaca 2760 acatcatggc cctctacctg aagaccaagg gcgacttcat cctggtgggc gaccttatgc 2820 gctcagtgct gctgcttgcc tacaagccca tggaaggaaa ctttgaagag attgctcgag 2880 actttaatcc caactggatg agtgctgtgg aaatcttgga tgatgacaat tttctggggg 2940 ctgaaaatgc ctttaacttg tttgtgtgtc aaaaggatag cgctgccacc actgacgagg 3000 agcggcagca cctccaggag gttggtcttt tccacctggg cgagtttgtc aatgtctttt 3060 gccacggctc tctggtaatg cagaatctgg gtgagacttc cacccccaca caaggctcgg 3120 tgctcttcgg cacggtcaac ggcatgatag ggctggtgac ctcactgtca gagagctggt 3180 acaacctcct gctggacatg cagaatcgac tcaataaagt catcaaaagt gtggggaaga 3240 tcgagcactc cttctggaga tcctttcaca ccgagcggaa gacagaacca gccacaggtt 3300 tcatcgacgg tgacttgatt gagagtttcc tggatattag ccgccccaag atgcaggagg 3360 tggtggcaaa cctacagtat gacgatggca gcggtatgaa gcgagaggcc actgcagacg 3420 acctcatcaa ggttgtggag gagctaactc ggatccatta gccaagggca gggggcccct 3480 ttgctgaccc tccccaaagg ctttgccctg ctgccctccc cctcctctcc accatcgtct 3540 tcttggccat gggaggcctt tccctaagcc agctgccccc agagccacag ttcccctatg 3600 tggaagtggg gcgggcttca tagagacttg ggaatgagct gaaggtgaaa cattttctcc 3660 ctggattttt accagtctca catgattcca gccatcacct tagaccacca agccttgatt 3720 ggtgttgcca gttgtcctct tccgggaaga tttgcagttc tttggctgaa ggaagctgtg 3780 cgtgtgtgtg tgtgtatgtt gtgggtatgt gtatctcaca ctcatgcatt gtcctctttt 3840 tatttagatt ggcagtgtag ggagttgtgg gtagtgggga agagggttag gagggtttca 3900 ttgtctgtga agtgagacct tccttttact tttcttctat tgcctctgag agcatagcta 3960 gaggcctgac tgccaagcca tgggtagcct gggtgtaaaa cctggagatg gtggatgatc 4020 cccacgccac agcccttttg tctctgcaaa ctgccttctt cggaaagaag aa 4072 <210> 396 <211> 4195 <212> DNA <213> Homo sapiens <400> 396 cgcttgtgtc cctctttcta gtgtcgcgct cgagtcccga cgggccgctc caagcctcga 60 catgtcgtac aactacgtgg taacggccca gaagcccacc gccgtgaacg gctgcgtgac 120 cggacacttt acttcggccg aagacttaaa cctgttgatt gccaaaaaca cgagattaga 180 gatctatgtg gtcaccgccg aggggcttcg gcccgtcaaa gaggtgggca tgtatgggaa 240 gattgcggtc atggagcttt tcaggcccaa gggggagagc aaggacctgc tgtttatctt 300 gacagcgaag tacaatgcct gcatcctgga gtataaacag agtggcgaga gcattgacat 360 cattacgcga gcccatggca atgtccagga ccgcattggc cgcccctcag agaccggcat 420 tattggcatc attgaccctg agtgccggat gattggcctg cgtctctatg atggcctttt 480 caaggttatt ccactagatc gcgataataa agaactcaag gccttcaaca tccgcctgga 540 ggagctgcat gtcattgatg tcaagttcct atatggttgc caagcaccta ctatttgctt 600 tgtctaccag gaccctcagg ggcggcacgt aaaaacctat gaggtgtctc tccgagaaaa 660 ggaattcaat aagggccctt ggaaacagga aaatgtcgaa gctgaagctt ccatggtgat 720 cgcagtccca gagccctttg ggggggccat catcattgga caggagtcaa tcacctatca 780 caatggtgac aaatacctgg ctattgcccc tcctatcatc aagcaaagca cgattgtgtg 840 ccacaatcga gtggacccta atggctcaag atacctgctg ggagacatgg aaggccggct 900 cttcatgctg cttttggaga aggaggaaca gatggatggc accgtcactc tcaaggatct 960 ccgtgtagaa ctccttggag agacctctat tgctgagtgc ttgacatacc ttgataatgg 1020 tgttgtgttt gtcgggtctc gcctgggtga ctcccagctt gtgaagctca acgttgacag 1080 taatgaacaa ggctcctatg tagtggccat ggaaaccttt accaacttag gacccattgt 1140 cgatatgtgc gtggtggacc tggagaggca ggggcagggg cagctggtca cttgctctgg 1200 ggctttcaag gaaggttctt tgcggatcat ccggaatgga attggaatcc acgagcatgc 1260 cagcattgac ttaccaggca tcaaaggatt atggccactg cggtctgacc ctaatcgtga 1320 gactgatgac actttggtgc tctcttttgt gggccagaca agagttctca tgttaaatgg 1380 agaggaggta gaagaaaccg aactgatggg tttcgtggat gatcagcaga ctttcttctg 1440 tggcaacgtg gctcatcagc agcttatcca gatcacttca gcatcggtga ggttggtctc 1500 tcaagaaccc aaagctctgg tcagtgaatg gaaggagcct caggccaaga acatcagtgt 1560 ggcctcctgc aatagcagcc aggtggtggt ggctgtaggc agggccctct actatctgca 1620 gatccatcct caggagctcc ggcagatcag ccacacagag atggaacatg aagtggcttg 1680 cttggacatc accccattag gagacagcaa tggactgtcc cctctttgtg ccattggcct 1740 ctggacggac atctcggctc gtatcttgaa gttgccctct tttgaactac tgcacaagga 1800 gatgctgggt ggagagatca ttcctcgctc catcctgatg accacctttg agagtagcca 1860 ttacctcctt tgtgccttgg gagatggagc gcttttctac tttgggctca acattgagac 1920 aggtctgttg agcgaccgta agaaggtgac tttgggcacc cagcccaccg tattgaggac 1980 ttttcgttct ctttctacca ccaacgtctt tgcttgttct gaccgcccca ctgtcatcta 2040 tagcagcaac cacaaattgg tcttctcaaa tgtcaacctc aaggaagtga actacatgtg 2100 tcccctcaat tcagatggct atcctgacag cctggcgctg gccaacaata gcaccctcac 2160 cattggcacc atcgatgaga tccagaagct gcacattcgc acagttcccc tctatgagtc 2220 tccaaggaag atctgctacc aggaagtgtc ccagtgtttc ggggtcctct ccagccgcat 2280 tgaagtccaa gacacgagtg ggggcacgac agccttgagg cccagcgcta gcacccaggc 2340 tctgtccagc agtgtaagct ccagcaagct gttctccagc agcactgctc ctcatgagac 2400 ctcctttgga gaagaggtgg aggtgcacaa cctacttatc attgaacaac acacctttga 2460 agtgcttcat gcccaccagt ttctgcagaa tgaatatgcc ctcagtctgg tttcctgcaa 2520 gctgggcaaa gaccccaaca cttacttcat tgtgggcaca gcaatggtgt atcctgaaga 2580 ggcagagccc aagtaggttc gcattgtggt ctttcagtat tcggatggaa aactacagac 2640 tgtggctgaa aaggaagtga aaggggccgt gtactctatg gcggaattta acgggaagct 2700 gttagccagc atcaatagca cggtgcggct ctatgagtgg acaacagaga aggagctgcg 2760 cactgagtgc aaccactaca acaacatcat ggccctctac ctgaagacca agggcgactt 2820 catcctggtg ggcgacctta tgcgctcagt gctgctgctt gcctacaagc ccatggaagg 2880 aaactttgaa gagattgctc gagactttaa tcccaactgg atgagtgctg tggaaatctt 2940 ggatgatgac aattttctgg gggctgaaaa tgcctttaac ttgtttgtgt gtcaaaagga 3000 tagcgctgcc accactgacg aggaaaagaa gcacctccag gaggttggtc ttttccacct 3060 gggcgagttt gtcaatgtct tttgccacgg ctctctggta atgcagaatc tgggtgagac 3120 ttccaccccc acacaaggct cggtgctctt cggcacggtc aacggcatga tagggctggt 3180 gacctcactg tcagagagct ggtacaacct cctgctggac atgcagaatc gactcaataa 3240 agtcatcaaa agtgtgggga agatcgagca ctccttctgg agatcctttc acaccgagcg 3300 gaagacagaa ccagccacag gtttcatcga cggtgacttg attgagagtt tcctggatat 3360 tagccgcccc aagatgcagg aggtggtggc aaacctacag tatgacgatg gcagcggtat 3420 gaagcgagag gccactgcag acgacctcat caaggttgtg gaggagctaa ctcggatcca 3480 ttagccaagg gcagggggcc cctttgctga ccctccccaa aggctttgcc ctgctgccct 3540 ccccctcctc tccaccatcg tcttcttggc catgggaggc ctttccctaa gccagctgcc 3600 cccagagcca cagttcccct atgtggaagt ggggcgggct tcatagagac ttgggaatga 3660 gctgaaggtg aaacattttc tccctggatt tttaccagtc tcacatgatt ccagccatca 3720 ccttagacca ccaagccttg attggtgttg ccagttgtcc tccttccggg gaaggatttt 3780 gcagttcttt ggctgaaagg aagctgtgcg tgtgtgtgtg tgtatgtgtg tgtgtgtatg 3840 tgtatctcac actcatgcat tgtcctcttt ttatttagat tggcagtgta gggagttgtg 3900 ggtagtgggg aagagggtta ggagggtttc attgtctgtg aagtgagacc ttccttttac 3960 ttttcttcta ttgcctctga gagcatcagg cctagaggcc tgactgccaa gccatgggta 4020 gcctgggtgt aaaacctgga gatggtggat gatccccacg ccacagccct tttgtctctg 4080 caaactgcct tcttcggaaa gaagaaggtg ggaggatgtg aattgttagt ttctgagttt 4140 taccaaataa agtagaatat aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa 4195 <210> 397 <211> 2293 <212> DNA <213> Homo sapiens <400> 397 gcgcttttct actttgggct caacattgag acaggtctgt tgagcgaccg taagaaggtg 60 actttgggca cccagcccac cgtattgagg acttttcgtt ctctttctac caccaacgtc 120 tttgcttgtt ctgaccgccc cactgtcatc tatagcagca accacaaatt ggtcttctca 180 aatgtcaacc tcaaggaagt gaactacatg tgtcccctca attcagatgg ctatcctgac 240 agcctggcgc tggccaacaa tagcaccctc accattggca ccatcgatga gatccagaag 300 ctgcacattc gcacagttcc cctctatgag tctccaagga agatctgcta ccaggaagtg 360 tcccagtgtt tcggggtcct ctccagccgc attgaagtcc aagacacgag tgggggcacg 420 acagccttga ggcccagcgc tagcacccag gctctgtcca gcagtgtaag ctccagcaag 480 ctgttctcca gcagcactgc tcctcatgag acctcctttg gagaagaggt ggaggtgcac 540 aacctactta tcattgacca acacaccttt gaagtgcttc atgcccacca gtttctgcag 600 aatgaatatg ccctcagtct ggtttcctgc aagctgggca aagaccccaa cacttacttc 660 attgtgggca cagcaatggt gtatcctgaa gaggcagagc ccaagcaggg tcgcattgtg 720 gtctttcagt attcggatgg aaaactacag actgtggctg aaaaggaagt gaaaggggcc 780 gtgtactcta tggtggaatt taacgggaag ctgttagcca gcatcaatag cacggtgcgg 840 ctctatgagt ggacaacaga gaaggagctg cgcactgagt gcaaccacta caacaacatc 900 atggccctct acctgaagac caagggcgac ttcatcctgg tgggcgacct tatgcgctca 960 gtgctgctgc ttgcctacaa gcccatggaa ggaaactttg aagagattgc tcgagacttt 1020 aatcccaact ggatgagtgc tgtggaaatc ttggatgatg acaattttct gggggctgaa 1080 aatgccttta acttgtttgt gtgtcaaaag gatagcgctg ccaccactga cgaggagcgg 1140 cagcacctcc aggaggttgg tcttttccac ctgggcgagt ttgtcaatgt cttttgccac 1200 ggctctctgg taatgcagaa tctgggtgag acttccaccc ccacacaagg ctcggtgctc 1260 ttcggcacgg tcaacggcat gatagggctg gtgacctcac tgtcagagag ctggtacaac 1320 ctcctgctgg acatgcagaa tcgactcaat aaagtcatca aaagtgtggg gaagatcgag 1380 cactccttct ggagatcctt tcacaccgag cggaagacag aaccagccac aggtttcatc 1440 gacggtgact tgattgagag tttcctggat attagccgcc ccaagatgca ggaggtggtg 1500 gcaaacctac agtatgacga tggcagcggt atgaagcgag aggccactgc agacgacctc 1560 atcaaggttg tggaggagct aactcggatc cattagccaa gggcaggggg cccctttgct 1620 gaccctcccc aaaggctttg ccctgctgcc ctccccctcc tctccaccat cgtcttcttg 1680 gccatgggag gcctttccct aagccagctg cccccagagc cacagttccc ctatgtggaa 1740 gtggggcggg cttcatagag acttgggaat gagctgaagg tgaaacattt tctccctgga 1800 tttttaccag tctcacatga ttccagccat caccttagac caccaagcct tgattggtgt 1860 tgccagttgt cctccttccg gggaaggatt ttgcagttct ttggctgaaa ggaagctgtg 1920 cgtgtgtgtg tgtgtatgtg tgtgtgtgta tgtgtatctc acactcatgc attgtcctct 1980 ttttatttag attggcagtg tagggagttg tgggtagtgg ggaagagggt taggagggtt 2040 tcattgtctg tgaagtgaga ccttcctttt acttttcttc tattgcctct gagagcatca 2100 ggcctagagg cctgactgcc aagccatggg tagcctgggt gtaaaacctg gagatggtgg 2160 atgatcccca cgccacagcc cttttgtctc tgcaaactgc cttcttcgga aagaagaagg 2220 tgggaggatg tgaattgtta gtttctgagt tttaccaaat aaagtagaat ataagaagaa 2280 aaaaaaaaaa aaa 2293 <210> 398 <211> 4032 <212> DNA <213> Homo sapiens <400> 398 gcctccttcg gttggcggcc tcgggcttcg ggagtcctcc aagaggccag gtgaggccgt 60 cccgtgatgc cccgcgcccc ggccgctctg gcctgcaacg tgtctctggg gcggaggcag 120 cggcagtggg gttcgctgcg cgctgttggg ggccacctgt cttttcgctt gtgtccctct 180 ttctagtgtc gcgctcgagt cccgacgggc cgctccaagc ctcgacatgt cgtacaacta 240 cgtggtaacg gcccagaagc ccaccgccgt gaacggctgc gtgaccggac actttacttc 300 ggccgaagac ttaaacctgt tgattgccaa aagcacgaga ttagagatct atgtggtcac 360 cgccgagggg cttcggcccg tcaaagaggt gggcatgtat gggaagattg cggtcatgga 420 gcttttcagg cccaaggggg agagcaagga cctgctgttt atcttgacag cgaagtacaa 480 tgcctgcatc ctggagtata aacagagtgg cgagagcatt gacatcatta cgcgagccca 540 tggcaatgtc caggaccgca ttggccgccc ctcagagacc ggcattattg gcatcattga 600 ccctgagtgc cggatgattg gcctgcgtct ctatgatggc cttttcaagg ttattccact 660 agatcgcgat aataaagaac tcaaggcctt caacatccgc ctggaggagc tgcatgtcat 720 tgatgtcaag ttcctatatg gctgccaagc acctactatt tgctttgtct accaggaccc 780 tcaggggcgg cacgtaaaaa cctatgaggt gtctctccga gaaaaggaat tcaataaggg 840 cccttggaaa caggaaaatg tcgaagctga agcttccatg gtgatcgcag tcccagagcc 900 ctttgggggg gccatcatca ttggacagga gtcaatcacc tatcacaatg gtgacaaata 960 cctggctatt gcccctccta tcatcaagca aagcacgatt gtgtgccaca atcgagtgga 1020 ccctaatggc tcaagatacc tgctgggaga catggaaggc cggctcttca tgctgctttt 1080 ggagaaggag gaacagatgg atggcaccgt cactctcaag gatctccgtg tagaactcct 1140 tggagagacc tctattgctg agtgcttgac ataccttgat aatggtgttg tgtttgtcgg 1200 gtctcgcctg ggtgactccc agcttgtgaa gctcaacgtt gacagtaatg aacaaggctc 1260 ctatgtagtg gccatggaaa cctttaccaa cttaggaccc attgtcgata tgtgcgtggt 1320 ggacctggag aggcaggggc aggggcagct ggtcacttgc tctggggctt tcaaggaagg 1380 ttctttgcgg atcatccgga atggaattgg aatccacgag catgccagca ttgacttacc 1440 aggcatcaaa ggattatggc cactgcggtc tgaccctaat cgtgagactg atgacacttt 1500 ggtgctctct tttgtgggcc agacaagagt tctcatgtta aatggagagg aggtagaaga 1560 aaccgaactg atgggtttcg tggatgatca gcagactttc ttctgtggca acgtggctca 1620 tcagcagctt atccaggtga taactgagaa aggggcaggt gttaccatat acttgaattg 1680 acctagatgc agtacagagc accactggat tttaaaacaa ccaattttta tggctccaaa 1740 aataatgtaa aaattctagg gaaaaaatta cagataatcc actactcaga aatcacaact 1800 cttaacctta gagttgctcc ttttagcttt atttttcttc tgcaaatgtc tgtgtattta 1860 tttacatttt cttttataga ctcgggtcat tatatatata aacataaaaa tatagtttcg 1920 gatcctattt tagcactaat tatatcctcc gagacactca aattttttcc ctttgttaaa 1980 ctagtgatac atccttattt ataaaattag aaaatgccaa aatgcacaaa aaaagaaaaa 2040 atcatgatgc taccatccaa tatgactctt ggcagccctt tccacatact aattataacc 2100 gaagcttacc ctattctgat ccttactttc aatctatctg caatacgggg gcagatagcc 2160 ttctggcata ttgttatcca cgagagccac tgtgcccggc cctgattaag tatttttaga 2220 gactcccaac tcaaactctg actaggctcc atctctgggc agttggcaac caaatgggct 2280 gcgttggcag agaggtcggg gagaatccct ctagggtgac acttgttgaa caccatgcta 2340 tatcttctgc agggtggggc cttgctcctg aataaaggaa acacaagtcc cagaactgga 2400 ttccgtgcaa actgctgatt atgctttctt ctttcacctt gtctgtttta agattgctcg 2460 agactttaat cccaactgga tgagtgctgt ggaaatcttg gatgatgaca attttctggg 2520 ggctgaaaat gcctttaact tgtttgtgtg tcaaaaggat aggtgagtag tggccagctc 2580 tgggagtggt gggggggctg ggagttcctt ggtctctggt ggatgcaagc attgggttct 2640 gtgtcaggtt caggtgctcc tgtttacaga gatagaactt tcctcgtcag agaataaaag 2700 gtgacagaaa tccacctctt tagactggct cccctactgt ggagtatgtc agctccccag 2760 ggaaattgag caccgtgacc actgcacgtg gtcctgtctc agggcctgtg gtggaaacag 2820 gaggttcaga aagtgacttt cttaccgcct ttcagcgctg ccaccactga cgaggagcgg 2880 cagcacctcc aggaggttgg tcttttccac ctgggcgagt ttgtcaatgt cttttgccac 2940 ggctctctgg taatgcagaa tctgggtgag acttccaccc ccacacaagg ctcggtgctc 3000 ttcggcacgg tcaacggcat gatagggctg gtgacctcac tgtcagagag ctggtacaac 3060 ctcctgctgg acatgcagaa tcgactcaat aaagtcatca aaagtgtggg gaagatcgag 3120 cactccttct ggtgatcctt tcacaccgag cggaagacag aaccagccac aggtttcatc 3180 gacggtgact tgattgaggg tttcctggat attagccgcc ccaagatgca ggaggtggtg 3240 gcaaacctac agtatgacga tggcagcggt atgaagcgag aggccactgc agacgacctc 3300 atcaaggttg tggaggagct aactcggatc cattagccaa gggcaggggg cccctttgct 3360 gaccctcccc aaaggctttg ccctgctgcc ctccccctcc tctccaccat cgtcttcttg 3420 gccatgggag gcctttccct aagccagctg cccccagagc cacagttccc ctatgtggaa 3480 gtggggcggg cttcatagag acttgggaat gagctgaagg tgaaacattt tctccctgga 3540 tttttaccag tctcacatga ttccagccat caccttagac caccaagcct tgattggtgt 3600 tgccagttgt cctccttccg gggaaggatt ttgcagttct ttggctgaaa ggaagctgtg 3660 cgtgtgtgtg tgtatgtgtg tgtgtgtatg tgtatctcac actcatgcat tgtcctcttt 3720 ttatttagat tggcagtgta gggagttgtg ggtagtgggg aagagggtta ggagggtttc 3780 attgtctgtg aagtgagacc ttccttttac ttttcttcta ttgcctctga gagcatcagg 3840 cctagaggcc tgactgccaa gccatgggta gcctgggtgt aaaacctgga gatggtggat 3900 gatccccacg ccacagccct tttgtctctg caaactgcct tcttcggaaa gaagaaggtg 3960 ggaggatgtg aattgttagt ttctgagttt taccaaataa agtagaatat aagaagaaaa 4020 aaaaaaaaaa aa 4032 <210> 399 <211> 1820 <212> DNA <213> Homo sapiens <400> 399 gagctccaag ctggtttgaa caagccctgg gcatgtttgg cgggaagttg gcttagctcg 60 gctacctgtg gccccgcagt tttgtagtcc ccgccttgtt tctccccaga ggcctctcaa 120 tcctccctcc atgatcttcg catagagcac agtacccctt cacacggagg acgcgatggc 180 tcccaagaaa cgcccagaaa cccagaagac ctccgagatt gtattacgcc ccaggaacaa 240 gaggagcagg agtcccctgg agctggagcc cgaggccaag aagctctgtg cgaagggctc 300 cggtcctagc agaagatgtg actcagactg cctctgggtg gggctggctg gcccacagat 360 cctgccacca tgccgcagca tcgtcaggac cctccaccag cataagctgg gcagagcttc 420 ctggccatct gtccagcagg ggctccagca gtcctttttg cacactctgg attcttaccg 480 gatattacaa aaggctgccc cctttgacag gagggctaca tccttggcgt ggcacccaac 540 tcaccccagc accgtggctg tgggttccaa agggggagat atcatgctct ggaattttgg 600 catcaaggac aaacccacct tcatcaaagg gattggagct ggagggagca tcactgggct 660 gaagtttaac cctctcaata ccaaccagtt ttacgcctcc tcaatggagg gaacaactag 720 gctgcaagac tttaaaggca acattctacg agtttttgcc agctcagaca ccatcaacat 780 ctggttttgt agcctggatg tgtctgctag tagccgaatg gtggtcacag gagacaacgt 840 ggggaacgtg atcctgctga acatggacgg caaagagctt tggaatctca gaatgcacaa 900 aaagaaagtg acgcatgtgg ccctgaaccc atgctgtgat tggttcctgg ccacagcctc 960 cgtagatcaa acagtgaaaa tttgggacct gcgccaggtt agagggaaag ccagcttcct 1020 ctactcgctg ccgcacaggc atcctgtcaa cgcagcttgt ttcagtcccg atggagcccg 1080 gctcctgacc acggaccaga agagcgagat ccgagtttac tctgcttccc agtgggactg 1140 ccccctgggc ctgatcccgc accctcaccg tcacttccag cacctcacac ccatcaaggc 1200 agcctggcat cctcgctaca acctcattgt tgtgggccga tacccagatc ctaatttcaa 1260 aagttgtacc ccttatgaat tgaggacgat cgacgtgttc gatggaaact cagggaagat 1320 gatgtgtcag ctctatgacc cagaatcttc tggcatcagt tcgcttaatg aattcaatcc 1380 catgggggac acgctggcct ctgcaatggg ttaccacatt ctcatctgga gccaggagga 1440 agccaggaca cggaagtgag agacactaaa gaaggtgtgg gccagacaag gccttggagc 1500 ccacacatgg gatcaagtcc tgcaagcaga ggtggtgatt tgttaaaggg ccaaaagtat 1560 ccaaggttag ggttggagca ggggtgctgg gacctggggc actgtgggac tgggacactt 1620 ttatgttaat gctctggact tgcctccaga gactgctcca gagttggtga cacagctgtc 1680 ccaagggccc ctctgtatct agcctggaac caaggttatc ttggaactaa atgacttttc 1740 tcctctcagt gggtggtagc agagggatca agcagttatt tgatttgtgc tcttttgata 1800 tggccaataa aaccataccg 1820 <210> 400 <211> 1820 <212> DNA <213> Homo sapiens <400> 400 gagctccaag ctggtttgaa caagccctgg gcatgtttgg cgggaagttg gcttagctcg 60 gctacctgtg gccccgcagt tttgtagtcc ccgccttgtt tctccccaga ggcctctcaa 120 tcctccctcc atgatcttcg catagagcac agtacccctt cacacggagg acgcgatggc 180 tcccaagaaa cgcccagaaa cccagaagac ctccgagatt gtattacgcc ccaggaacaa 240 gaggagcagg agtcccctgg agctggagcc cgaggccaag aagctctgtg cgaagggctc 300 cggtcctagc agaagatgtg actcagactg cctctgggtg gggctggctg gcccacagat 360 cctgccacca tgccgcagca tcgtcaggac cctccaccag cataagctgg gcagagcttc 420 ctggccatct gtccagcagg ggctccagca gtcctttttg cacactctgg attcttaccg 480 gatattacaa aaggctgccc cctttgacag gagggctaca tccttggcgt ggcacccaac 540 tcaccccagc accgtggctg tgggttccaa agggggagat atcatgctct ggaattttgg 600 catcaaggac aaacccacct tcatcaaagg gattggagct ggagggagca tcactgggct 660 gaagtttaac cctctcaata ccaaccagtt ttacgcctcc tcaatggagg gaacaactag 720 gctgcaagac tttaaaggca acattctacg agtttttgcc agctcagaca ccatcaacat 780 ctggttttgt agcctggatg tgtctgctag tagccgaatg gtggtcacag gagacaacgt 840 ggggaacgtg atcctgctga acatggacgg caaagagctt tggaatctca gaatgcacaa 900 aaagaaagtg acgcatgtgg ccctgaaccc atgctgtgat tggttcctgg ccacagcctc 960 cgtagatcaa acagtgaaaa tttgggacct gcgccaggtt agagggaaag ccagcttcct 1020 ctactcgctg ccgcacaggc atcctgtcaa cgcagcttgt ttcagtcccg atggagcccg 1080 gctcctgacc acggaccaga agagcgagat ccgagtttac tctgcttccc agtgggactg 1140 ccccctgggc ctgatcccgc accctcaccg tcacttccag cacctcacac ccatcaaggc 1200 agcctggcat cctcgctaca acctcattgt tgtgggccga tacccagatc ctaatttcaa 1260 aagttgtacc ccttatgaat tgaggacgat cgacgtgttc gatggaaact cagggaagat 1320 gatgtgtcag ctctatgacc cagaatcttc tggcatcagt tcgcttaatg aattcaatcc 1380 catgggggac acgctggcct ctgcaatggg ttaccacatt ctcatctgga gccaggagga 1440 agccaggaca cggaagtgag agacactaaa gaaggtgtgg gccagacaag gccttggagc 1500 ccacacatgg gatcaagtcc tgcaagcaga ggtggtgatt tgttaaaggg ccaaaagtat 1560 ccaaggttag ggttggagca ggggtgctgg gacctggggc actgtgggac tgggacactt 1620 ttatgttaat gctctggact tgcctccaga gactgctcca gagttggtga cacagctgtc 1680 ccaagggccc ctctgtatct agcctggaac caaggttatc ttggaactaa atgacttttc 1740 tcctctcagt gggtggtagc agagggatca agcagttatt tgatttgtgc tcttttgata 1800 tggccaataa aaccataccg 1820 <210> 401 <211> 1695 <212> DNA <213> Homo sapiens <400> 401 taccccttca cacggaggac gcgatggctc ccaagaaacg cccagaaacc cagaagacct 60 ccgagattgt attacgcccc aggaacaaga ggagcaggag tcccctggag ctggagcccg 120 aggccaagaa gctctgtgcg aagggctccg gtcctagcag aagatgtgac tcagactgcc 180 tctgggtggg gctggctggc ccacagatcc tgccaccatg ccgcagcatc gtcaggaccc 240 tccaccagca taagctgggc agagcttcct ggccatctgt ccagcagggg ctccagcagt 300 cctttttgca cactctggat tcttaccgga tattacaaaa ggctgccccc tttgacagga 360 gggctacatc cttggcgtgg cacccaactc accccagcac cgtggctgtg ggttccaaag 420 ggggagatat catgctctgg aattttggca tcaaggacaa acccaccttc atcaaaggga 480 ttggagctgg agggagcatc actgggctga agtttaaccc tctcaatacc aaccagtttt 540 acgcctcctc aatggaggga acaactaggc tgcaagactt taaaggcaac attctacgag 600 tttttgccag ctcagacacc atcaacatct ggttttgtag cctggatgtg tctgctagta 660 gccgaatggt ggtcacagga gacaacgtgg ggaacgtgat cctgctgaac atggacggca 720 aagagctttg gaatctcaga atgcacaaaa agaaagtgac gcatgtggcc ctgaacccat 780 gctgtgattg gttcctggcc acagcctccg tagatcaaac agtgaaaatt tgggacctgc 840 gccaggttag agggaaagcc agcttcctct actcgctgcc gcacaggcat cctgtcaacg 900 cagcttgttt cagtcccgat ggagcccggc tcctgaccac ggaccagaag agcgagatcc 960 gagtttactc tgcttcccag tgggactgcc ccctgggcct gatcccgcac cctcaccgtc 1020 acttccagca cctcacacct atcaaggcag cctggcatcc tcgctacaac ctcattgttg 1080 tgggccgata cccagatcct aatttcaaaa gttgtacccc ttatgaattg aggacgatcg 1140 acgtgttcga tggaaactca gggaagatga tgtgtcagct ctatgaccca gaatcttctg 1200 gcatcagttc gcttaatgaa ttcaatccca tgggggacac gctggcctct gcaatgggtt 1260 accacattct catctggagc caggaggaag ccaggacacg gaagtgagag acactaaaga 1320 aggtgtgggc cagacaaggc cttggagccc acacatggga tcaagtcctg caagcagagg 1380 tggcgatttg ttaaagggcc aaaagtatcc aaggttaggg ttggagcagg ggtgctggga 1440 cctggggcac tgtgggactg ggacactttt atgttaatgc tctggacttg cctccagaga 1500 ctgctccaga gttggtgaca cagctgtccc aagggcccct ctgtatctag cctggaacca 1560 aggttatctt ggaactaaat gacttttctc ctctcagtgg gtggtagcag agggatcaag 1620 cagttatttg atttgtgctc acttttgata tggccaataa aaccataccg actgaaaaaa 1680 aaaaaaaaaa aaaaa 1695 <210> 402 <211> 1284 <212> DNA <213> Homo sapiens <400> 402 atggctccca agaaacgccc agaaacccag aagacctccg agattgtatt acgccccagg 60 aacaagagga gcaggagtcc cctggagctg gagcccgagg ccaagaagct ctgtgcgaag 120 ggctccggtc ctagcagaag atgtgactca gactgcctct gggtggggct ggctggccca 180 cagatcctgc caccatgccg cagcatcgtc aggaccctcc accagcataa gctgggcaga 240 gcttcctggc catctgtcca gcaggggctc cagcagtcct ttttgcacac tctggattct 300 taccggatat tacaaaaggc tgcccccttt gacaggaggg ctacatcctt ggcgtggcac 360 ccaactcacc ccagcaccgt ggctgtgggt tccaaagggg gagatatcat gctctggaat 420 tttggcatca aggacaaacc caccttcatc aaagggattg gagctggagg gagcatcact 480 gggctgaagt ttaaccctct caataccaac cagttttacg cctcctcaat ggagggaaca 540 actaggctgc aagactttaa aggcaacatt ctacgagttt ttgccagctc agacaccatc 600 aacatctggt tttgtagcct ggatgtgtct gctagtagcc gaatggtggt cacaggagac 660 aacgtgggga acgtgatcct gctgaacatg gacggcaaag agctttggaa tctcagaatg 720 cacaaaaaga aagtgacgca tgtggccctg aacccatgct gtgattggtt cctggccaca 780 gcctccgtag atcaaacagt gaaaatttgg gacctgcgcc aggttagagg gaaagccagc 840 ttcctctact cgctgccgca caggcatcct gtcaacgcag cttgtttcag tcccgatgga 900 gcccggctcc tgaccacgga ccagaagagc gagatccgag tttactctgc ttcccagtgg 960 gactgccccc tgggcctgat cccgcaccct caccgtcact tccagcacct cacacctatc 1020 aaggcagcct ggcatcctcg ctacaacctc attgttgtgg gccgataccc agatcctaat 1080 ttcaaaagtt gtacccctta tgaattgagg acgatcgacg tgttcgatgg aaactcaggg 1140 aagatgatgt gtcagctcta tgacccagaa tcttctggca tcagttcgct taatgaattc 1200 aatcccatgg gggacacgct ggcctctgca atgggttacc acattctcat ctggagccag 1260 gaggaagcca ggacacggaa gtag 1284 <210> 403 <211> 2229 <212> DNA <213> Homo sapiens <400> 403 attaactgag cacttgctgc tatttctaga catgaaatgt caccttgctg aggcccagcc 60 cagcccagca tagcccgagg gctggaaaaa cgctttcatc tctaaaactg agaaatcatc 120 ataattgtgc tttcacttcc caggctccat gtgtcttgga gccgtcaccc cgaggctccc 180 tctttaggtc ggagattggc cttgcctgtc gaggcaagag gctgcagagg cggggacaca 240 cctgtgtcct ccgggagagg ccccctcctc tccccagacc acagggggcc tctctgcctc 300 cagccccacc ttccccggga gaagctttcc ccaatcccca ggtctctaga tcattctgtt 360 ctcgagtatc ctgtggagga ggcaaaaatg cctggcgccc cttctctcca agctcaattc 420 tctaagcccc tcagggtctc cggctacctg tggccccgca gttttgtagt ccccgccttg 480 tttctcccca gaggcctctc aatcctccct ccatgatctt cgcatagagc acagtacccc 540 ttcacacgga ggacgcgatg gctcccaaga aacgcccaga aacccagaag acctccgaga 600 ttgtattacg ccccaggaac aagaggagca ggagtcccct ggagctggag cccgaggcca 660 agaagctctg tgcgaagggc tccggtccta gcagaagatg tgactcagac tgcctctggg 720 tggggctggc tggcccacag atcctgccac catgccgcag catcgtcagg accctccacc 780 agcataagct gggcagagct tcctggccat ctgtccagca ggggctccag cagtcctttt 840 tgcacactct ggattcttac cggatattac aaaaggctgc cccctttgac aggagggcta 900 catccttggc gtggcaccca actcacccca gcaccgtggc tgtgggttcc aaagggggag 960 atatcatgct ctggaatttt ggcatcaagg acaaacccac cttcatcaaa gggattggag 1020 ctggagggag catcactggg ctgaagttta accctctcaa taccaaccag ttttacgcct 1080 cctcaatgga gggaacaact aggctgcaag actttaaagg caacattcta cgagtttttt 1140 gccagctcag acaccatcaa catctggttt tgtagcctgg atgtgtctgc tagtagccga 1200 atggtggtca caggagacaa cgtggggaac gtgatcctgc tgaacatgga cggcaaagag 1260 ctttggaatc tcagaatgca caaaaagaaa gtgacgcatg tggccctgaa cccatgctgt 1320 gattggttct tggccacagc ctccgtagat caaacagtga aaatttggga cctgcgccag 1380 gttagaggga aagccagctt cctctactcg ctgccgcaca ggcatcctgt caacgcagct 1440 tgtttcagtc ccgatggagc ccggctcctg accacggacc agaagagcga gatccgagtt 1500 tactctgctt cccagtggga ctgccccctg ggcctgatcc cgcaccctca ccgtcacttc 1560 cagcacctca cacccatcaa ggcagcctgg catcctcgct acaacctcat tgttgtgggc 1620 cgatacccag atcctaattt caaaagttgt accccttatg aattgaggac gatcgacgtg 1680 ttcgatggaa actcagggaa gatgatgtgt cagctctatg acccagaatc ttctggcatc 1740 agttcgctta atgaattcaa tcccatgggg gacacgctgg cctctgcaat gggttaccac 1800 attctcatct ggagccagga ggaagccagg acacggaagt gagagacact aaagaaggtg 1860 tgggccagac aaggccttgg agcccacaca tgggatcaag tcctgcaagc agaggtggcg 1920 atttgttaaa gggccaaaag tatccaaggt tagggttgga gcaggggtgc tgggacctgg 1980 ggcactgtgg gactgggaca cttttatgtt aatgctctgg acttgcctcc agagactgct 2040 ccagagttgg tgacacagct gtcccaaggg cccctctgta tctagcctgg aaccaaggtt 2100 atcttggaac taaatgactt ttctcctctc agtgggtggt agcagaggga tcaagcagtt 2160 atttgatttg tgctcacttt tgatatggcc aataaaacca taccgactga aaaaaaaaaa 2220 aaaaaaaaa 2229 <210> 404 <211> 3158 <212> DNA <213> Homo sapiens <400> 404 atcttcgcat agagcacagt accccttcac acggaggacg cgatggctcc caagaaacgc 60 ccagaaaccc agaagacctc cgagattgta ttacgcccca ggaacaagag gagcaggagt 120 cccctggagc tggagcccga ggccaagaag ctctgtgcga agggctccgg tactgcctgt 180 gcctgctgct tgaatatttc cgccttttag ggtgctcgcg caggaggctg cagcggggga 240 tgggtgctcc gaggctcccg aggcccgcgc aggtcacggg tgcctccggc tgtgcattct 300 acctgcaggt cctttgacac cagagtgttt aggtttcaac acctctcccg ctaggtaaca 360 ggaagcagat gagctccgta acaacagaca cacggacttg tcagattcct tgttcgtatc 420 agggttcttg cacagttagg acggcttcag agaatcctac ctttcctggc gctgtgtgtg 480 ctggatttca tagtcacgct tgttagctgc acgtcctcgg tggtcagttg tgagagcccc 540 caattccttc ctccttagaa agctcattct ctgaggttta ctggggcttg aacctggggc 600 tataaggagt ttcgagacac tcaaaaacga gctggggctt gttaatcaag tggtttttgt 660 ccatgagaag aaagaattgg ttgtcaagac gtcggaccta tagtgattgg gtcctcaaat 720 acagtttggt gatcaggagt tgttgcttta ttgctattct aatttcactt acctccccag 780 aagtaaccta gttaagagca tttccaggcc ttcctattcc ttcttttcct aaacggtgac 840 ttctgccatg ctgccctaaa atctttttat tgtgcattat atgtgattta taaaattgtg 900 acccagtccc atctcgagtt ttgcagccca aactgggaag agttctgcat tgtactttat 960 ccttgtgtgt ttctttggct ggggtctcag gaaccctgca cgactgtatt tactttcact 1020 tcagacttac tgtttgtggg agtgttttgg ggaaggggcc aaatcctcac tcattttttt 1080 atttctggtg ctcgttgaga ccacacagac atggaaaggc cgcaggaggt gatgagacag 1140 agattaaccg tgccgaatga aacaaggctt cctttcgggg aattcagcag aaaaaccttt 1200 cgtgagattg gagaggaaaa tatgtctgtt ctgcttggca ggtcctagca gaagatgtga 1260 ctcagactgc ctctgggtgg ggctggctgg cccacagatc ctgccaccat gccgcagcat 1320 cgtcaggacc ctccaccagc ataagctggg cagagcttcc tggccatctg tccagcaggg 1380 gctccagcag tcctttttgc acactctgga ttcttaccgg atattacaaa aggctgcccc 1440 ctttgacagg agggctacat ccttggcgtg gcacccaact caccccagca ccgtggctgt 1500 gggttccaaa gggggagata tcatgctctg gaattttggc atcaaggaca aacccacctt 1560 catcaaaggg attggagctg gagggagcat cactgggctg aagtttaacc ctctcaatac 1620 caaccagttt tacgcctcct caatggaggg aacaactagg ctgcaagact ttaaaggcaa 1680 cattctacga gtttttgcca gctcagacac catcaacatc tggttttgta gcctggatgt 1740 gtctgctagt agccgaatgg tggtcacagg agacaacgtg gggaacgtga tcctgctgaa 1800 catggacggc aaagagcttt ggaatctcag aatgcacaaa aagaaagtga cgcatgtggc 1860 cctgaaccca tgctgtgatt ggttcctggc cacagcctcc gtagatcaaa cagtgaaaat 1920 ttgggacctg cgccaggtta gagggaaagc cagcttcctc tactcgctgc cgcacaggca 1980 tcctgtcaac gcaggtgtga tatcccagac ctcatctctc ctgcagaccc tgcctgtctg 2040 accactgctg gggttttccc tcagtgtgga agccactacg tcaaaccttt acccctgata 2100 gcgtctgcca agctgatgtc tgggaacctt tgtggctgtg gctgtcccca tcagctgctg 2160 agtttccaga atttttttgt tgttgttcac agcccagatt cacctcttcc tttccgctcc 2220 tgtctagaga ggagtgggag ggagagtacc cctgcaggag aaggcctgca aggccaggac 2280 cacagagggc ttgtggttcc ttcagctcag gggcttttca ctttgccagc ttgtttcagt 2340 cccgatggag cccggctcct gaccacggac cagaagagcg agatccgagt ttactctgct 2400 tcccagtggg actgccccct gggcctgatc ccgcaccctc accgtcactt ccagcacctc 2460 acacccatca aggcagcctg gcatcctcgc tacaacctca ttgttgtggg ccgataccca 2520 gatcctaatt tcaaaagttg taccccttat gaattgagga cgatcgacgt gttcgatgga 2580 aactcaggga agatgatgtg tcagctctat gacccagaat cttctggcat cagttcgctt 2640 aatgaattca atcccatggg ggacacgctg gcctctgcaa tgggttacca cattctcatc 2700 tggagccagg aggaagccag gacacggaag tgagagacac taaagaaggt gtgggccaga 2760 caaggccttg gagcccacac atgggatcaa gtcctgcaag cagaggtggc gatttgttaa 2820 agggccaaaa gtatccaagg ttagggttgg agcaggggtg ctgggacctg gggcactgtg 2880 ggactgggac acttttatgt taatgctctg gacttgcctc cagagactgc tccagagttg 2940 gtgacacagc tgtcccaagg gcccctctgt atctagcctg gaaccaaggt tatcttggaa 3000 ctaaatgact tttctcctct cagtgggtgg tagcagaggg atcaagcagt tatttgattt 3060 gtgctcactt ttgatatggc caataaaacc ataccgactg aaaaaaaaaa aaaaaaaaaa 3120 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa 3158 <210> 405 <211> 2181 <212> DNA <213> Homo sapiens <400> 405 agtacccctt cacacggagg acgcgatggc tcccaagaaa cgcccagaaa cccagaagac 60 ctccgagatt gtattacgcc ccaggaacaa gaggagcagg agtcccctgg agctggagcc 120 cgaggccaag aagctctgtg cgaagggctc cggtactgcc tgtgcctgct gcttgaatat 180 ttccgccttt tagggtgctc gcgcaggagg ctgcagcggg ggatgggtgc tccgaggctc 240 ccgaggcccg cgcaggtcac gggtgcctcc ggctgtgcat tctacctgca ggtcctttga 300 caccagagtg tttaggtttc aacacctctc ccgctaggta acaggaagca gatgagctcc 360 gtaacaacag acacacggac ttgtcagatt ccttgttcgt atcagggttc ttgcacagtt 420 aggacggctt cagagaatcc tacctttcct ggcgctgtgt gtgctggatt tcatagtcac 480 gcttgttagc tgcacgtcct cggtggtcag ttgtgagagc ccccaattcc ttcctcctta 540 gaaagctcat tctctgaggt ttactggggc ttgaacctgg ggctataagg agtttcgaga 600 cactcaaaaa cgagctgggg cttgttaatc aagtggtttt tgtccatgag aagaaagaat 660 tggttgtcaa gacgtcggac ctatagtgat tgggtcctca aatacagttt ggtgatcagg 720 agttgttgct ttattgctat tctaatttca cttacctccc cagaagtaac ctagttaaga 780 gcatttccag gccttcctat tccttctttt cctaaacggt gacttctgcc atgctgccct 840 aaaatctttt tattgtgcat tatatgtgat ttataaaatt gtgacccagt cccatctcga 900 gttttgcagc ccaaactggg aagagttctg cattgtactt tatccttgtg tgtttctttg 960 gctggggtct caggaaccct gcacgactgt atttactttc acttcagact tactgtttgt 1020 gggagtgttt tggggaaggg gccaaatcct cactcatttt tttatttctg gtgctcgttg 1080 agaccacaca gacatggaaa ggccgcagga ggtgatgaga cagagattaa ccgtgccgaa 1140 tgaaacaagg cttcctttcg gggaattcag cagaaaaacc tttcgtgaga ttggagagga 1200 aaatatgtct gttctgcttg gcaggtccta gcagaagatg tgactcagac tgcctctggg 1260 tggggctggc tggcccacag atcctgccac catgccgcag catcgtcagg accctccacc 1320 agcataagct gggcagagct tcctggccat ctgtccagca ggggctccag cagtcctttt 1380 tgcacactct ggattcttac cggatattac aaaaggctgc cccctttgac aggagggcta 1440 catccttggc gtggcaccca actcacccca gcaccgtggc tgtgggttcc aaagggggag 1500 atatcatgct ctggaatttt ggcatcaagg acaaacccac cttcatcaaa ggggcagcct 1560 ggcatcctcg ctacaacctc attgttgtgg gccgataccc agatcctaat ttcaaaagtt 1620 gtacccctta tgaattgagg acgatcgacg tgttcgatgg aaactcaggg aagatgatgt 1680 gtcagctcta tgacccagaa tcttctggca tcagttcgct taatgaattc aatcccatgg 1740 gggacacgct ggcctctgca atgggttacc acattctcat ctggagccag gaggaagcca 1800 ggacacggaa gtgagagaca ctaaagaagg tgtgggccag acaaggcctt ggagcccaca 1860 catgggatca agtcctgcaa gcagaggtgg tgatttgtta aagggccaaa agtatccaag 1920 gttagggttg gagcaggggt gctgggacct ggggcactgt gggactggga cacttttatg 1980 ttaatgctct ggacttgcct ccagagactg ctccagagtt ggtgacacag ctgtcccaag 2040 ggcccctctg tatctagcct ggaaccaagg ttatcttgga actaaatgac ttttctcctc 2100 tcagtgggtg gtagcagagg gatcaagcag ttatttgatt tgtgctcact tttgatatgg 2160 ccaataaaac cataccgact g 2181 <210> 406 <211> 2682 <212> DNA <213> Homo sapiens <400> 406 tctcctgtac ctgggcatcc agaaaaatgg tggtgatggc gcgactctcg cggcccgagc 60 ggccggacct tgtcttcgag gaagaggacc tcccctatga ggaggaaatc atgcggaacc 120 aattctctgt caaatgctgg cttcgctaca tcgagttcaa acagggcgcc ccgaagccca 180 ggctcaatca gctatacgag cgggcactca agctgctgcc ctgcagtacc aaactctggt 240 accgatacct gaaggcgcgt cgggcacagg tgaagcatcg ctgtgtgacc gaccctgcct 300 atgaagatgt caacaactgt catgagaggg cctttgtgtt catgcacaag atgcctcgtc 360 tgtggctaga ttactgccag ttcctcatgg accaggggcg cgtcacacac acccgccgca 420 ccttcgaccg tgccctccgg gcactgccca tcacgcagca ctctcgaatt tggcccctgt 480 atctgcgctt cctgcgctca cacccactgc ctgagacagc tgtgcgaggc tatcggcgct 540 tcctcaagct gagtcctgag agtgcagagg agtacattga gtacctcaag tcaagtgacc 600 ggctggatga ggccgcccag cgcctggcca ccgtggtgaa cgacgagcgt ttcgtgtcta 660 aggccggcaa gtccaactac cagctgtggc acgagctgtg cgacctcatc tcccagaatc 720 cggacaaggt acagtccctc aatgtggacg ccatcatccg cgggggcctc acccgcttca 780 ccgaccagct gggcaagctc tggtgttctc tcgccgacta ctacatccgc agcggccatt 840 tcgagaaggc tcgggacgtg tacgaggagg ccatccggac agtgatgacc gtgcgggact 900 tcacacaggt gtttgacagc tacgcccagt tcgaggagag catgatcgct gcaaagatgg 960 agaccgctcg gaactggggc gcgaggagga ggatgatgtg gacctggagc tgcgcctggc 1020 ccgcttcgag cagctcatca gccggcggcc cctgctcctc aacagcgtct tgctgcgcca 1080 aaacccacac cacgtgcacg agtggcacaa gcgtgtcgcc ctgcaccagg gccgcccccg 1140 ggagatcatc aacacctaca cagaggctgt gcagacggtg gaccccttca aggccacagg 1200 caagccccac actctgtggg tggcgtttgc caagttttat gaggacaacg gacagcttgg 1260 acgatgcccg tgtcattctg gagaaggcca ccaaggtgaa ctttcaagca ggttggatga 1320 cctggcaagc gtgtggtgtc agtgcggaga gctggagctc cgacacgaga actacgatga 1380 ggccttgcgg ctgctgcgaa aggccacggc gctgcctgcc cgccgggtcg aagtactttg 1440 atggttcaga gcccgtgcag aaccgcgtgt acaagtcact gaaggtctgg tccatgctcg 1500 ccgacctgga ggagagcctc ggcaccttcc agtccaccaa ggccgtgtac gaccgcatcc 1560 tggacctgcg tatcgcaaca ccccagatcg tcatcaacta tgccatgttc ctggaggagc 1620 acaagtactt cgaggagagc ttcaaggcgt acgagcgcgg catctcgctg ttcaagtggc 1680 ccaacgtgtc cgacatctgg agcacctacc tgaccaaatt cattgcccgc tatgggggcc 1740 gcaagctgga gcgggcacgg gacctgtttg aacaggctct ggacggctgc cccccaaaat 1800 atgccaagac cttgtacctg ctgtacgcac agctggagga ggagtggggc ctggcccggc 1860 atgccatggc cgtgtacgag cgtgccacca gggccgtgga gcccgcccag cagtatgaca 1920 tgttcaacat ctacatcaag cgggcggccg agatctatgg ggtcacccac acccgcggca 1980 tctaccagaa ggccattgag gtgctgtcgg acgagcacgc gcgtgagatg tgcctgcggt 2040 ttgcagacat ggagtgcaag ctcgggaaga ttgaccgcgc ccgggccatc tacagcttct 2100 gctcccagat ctgtgacccc cggacgaccg gcgcgttctg gcagacgtgg aaggactttg 2160 aggtccggca tggcaatgag gacaccatca aggaaatgct gcgtatccgg cgcagcgtgc 2220 aggccacgta caacacgcag gtcaacttca tggcctcgca gatgctcaag gtctcgggca 2280 tcccgggcac cgtgtctgac ctggcccctg ggcagagtgg catggacgac atgaagctgc 2340 tggaacagcg ggcagagcag ctggcggctg aggcggagcg tgaccagccc ttgcgcgccc 2400 agagcaagat cctgttcgtg aggagtgacg cctcccggga ggagctggca gagctggcac 2460 agcaggtcaa ccccgaggag atccagctgg gcgaggacga ggacgaggac gagatggacc 2520 tggagcccaa cgaggttcgg ctggagcagc agagcgtgcc agccgcagtg tttgggagcc 2580 tgaaggaaga ctgacccgtc cctcccccat cccccctccc cacccccatc cccaatacag 2640 ctacgtttgt acatcaaaaa aaaaaaaaaa aaaaaaaaaa aa 2682 <210> 407 <211> 2682 <212> DNA <213> Homo sapiens <400> 407 tctcctgtac ctgggcatcc agaaaaatgg tggtgatggc gcgactctcg cggcccgagc 60 ggccggacct tgtcttcgag gaagaggacc tcccctatga ggaggaaatc atgcggaacc 120 aattctctgt caaatgctgg cttcgctaca tcgagttcaa acagggcgcc ccgaagccca 180 ggctcaatca gctatacgag cgggcactca agctgctgcc ctgcagtacc aaactctggt 240 accgatacct gaaggcgcgt cgggcacagg tgaagcatcg ctgtgtgacc gaccctgcct 300 atgaagatgt caacaactgt catgagaggg cctttgtgtt catgcacaag atgcctcgtc 360 tgtggctaga ttactgccag ttcctcatgg accaggggcg cgtcacacac acccgccgca 420 ccttcgaccg tgccctccgg gcactgccca tcacgcagca ctctcgaatt tggcccctgt 480 atctgcgctt cctgcgctca cacccactgc ctgagacagc tgtgcgaggc tatcggcgct 540 tcctcaagct gagtcctgag agtgcagagg agtacattga gtacctcaag tcaagtgacc 600 ggctggatga ggccgcccag cgcctggcca ccgtggtgaa cgacgagcgt ttcgtgtcta 660 aggccggcaa gtccaactac cagctgtggc acgagctgtg cgacctcatc tcccagaatc 720 cggacaaggt acagtccctc aatgtggacg ccatcatccg cgggggcctc acccgcttca 780 ccgaccagct gggcaagctc tggtgttctc tcgccgacta ctacatccgc agcggccatt 840 tcgagaaggc tcgggacgtg tacgaggagg ccatccggac agtgatgacc gtgcgggact 900 tcacacaggt gtttgacagc tacgcccagt tcgaggagag catgatcgct gcaaagatgg 960 agaccgctcg gaactggggc gcgaggagga ggatgatgtg gacctggagc tgcgcctggc 1020 ccgcttcgag cagctcatca gccggcggcc cctgctcctc aacagcgtct tgctgcgcca 1080 aaacccacac cacgtgcacg agtggcacaa gcgtgtcgcc ctgcaccagg gccgcccccg 1140 ggagatcatc aacacctaca cagaggctgt gcagacggtg gaccccttca aggccacagg 1200 caagccccac actctgtggg tggcgtttgc caagttttat gaggacaacg gacagcttgg 1260 acgatgcccg tgtcattctg gagaaggcca ccaaggtgaa ctttcaagca ggttggatga 1320 cctggcaagc gtgtggtgtc agtgcggaga gctggagctc cgacacgaga actacgatga 1380 ggccttgcgg ctgctgcgaa aggccacggc gctgcctgcc cgccgggtcg aagtactttg 1440 atggttcaga gcccgtgcag aaccgcgtgt acaagtcact gaaggtctgg tccatgctcg 1500 ccgacctgga ggagagcctc ggcaccttcc agtccaccaa ggccgtgtac gaccgcatcc 1560 tggacctgcg tatcgcaaca ccccagatcg tcatcaacta tgccatgttc ctggaggagc 1620 acaagtactt cgaggagagc ttcaaggcgt acgagcgcgg catctcgctg ttcaagtggc 1680 ccaacgtgtc cgacatctgg agcacctacc tgaccaaatt cattgcccgc tatgggggcc 1740 gcaagctgga gcgggcacgg gacctgtttg aacaggctct ggacggctgc cccccaaaat 1800 atgccaagac cttgtacctg ctgtacgcac agctggagga ggagtggggc ctggcccggc 1860 atgccatggc cgtgtacgag cgtgccacca gggccgtgga gcccgcccag cagtatgaca 1920 tgttcaacat ctacatcaag cgggcggccg agatctatgg ggtcacccac acccgcggca 1980 tctaccagaa ggccattgag gtgctgtcgg acgagcacgc gcgtgagatg tgcctgcggt 2040 ttgcagacat ggagtgcaag ctcgggaaga ttgaccgcgc ccgggccatc tacagcttct 2100 gctcccagat ctgtgacccc cggacgaccg gcgcgttctg gcagacgtgg aaggactttg 2160 aggtccggca tggcaatgag gacaccatca aggaaatgct gcgtatccgg cgcagcgtgc 2220 aggccacgta caacacgcag gtcaacttca tggcctcgca gatgctcaag gtctcgggca 2280 tcccgggcac cgtgtctgac ctggcccctg ggcagagtgg catggacgac atgaagctgc 2340 tggaacagcg ggcagagcag ctggcggctg aggcggagcg tgaccagccc ttgcgcgccc 2400 agagcaagat cctgttcgtg aggagtgacg cctcccggga ggagctggca gagctggcac 2460 agcaggtcaa ccccgaggag atccagctgg gcgaggacga ggacgaggac gagatggacc 2520 tggagcccaa cgaggttcgg ctggagcagc agagcgtgcc agccgcagtg tttgggagcc 2580 tgaaggaaga ctgacccgtc cctcccccat cccccctccc cacccccatc cccaatacag 2640 ctacgtttgt acatcaaaaa aaaaaaaaaa aaaaaaaaaa aa 2682 <210> 408 <211> 2664 <212> DNA <213> Homo sapiens <400> 408 ccagaaaaat ggtggtgatg gcgcgactct cgcggcccga gcggccggac cttgtcttcg 60 aggaagagga cctcccctat gaggaggaaa tcatgcggaa ccaattctct gtcaaatgct 120 ggcttcgcta catcgagttc aaacagggcg ccccgaagcc caggctcaat cagctatacg 180 agcgggcact caagctgctg ccctgcagct acaaactctg gtaccgatac ctgaaggcgc 240 gtcgggcaca ggtgaagcat cgctgtgtga ccgaccctgc ctatgaagat gtcaacaact 300 gtcatgagag ggcctttgtg ttcatgcaca agatgcctcg tctgtggcta gattactgcc 360 agttcctcat ggaccagggg cgcgtcacac acacccgccg caccttcgac cgtgccctcc 420 gggcactgcc catcacgcag cactctcgaa tttggcccct gtatctgcgc ttcctgcgct 480 cacacccact gcctgagaca gctgtgcgag gctatcggcg cttcctcaag ctgagtcctg 540 agagtgcaga ggagtacatt gagtacctca agtcaagtga ccggctggat gaggccgccc 600 agcgcctggc caccgtggtg aacgacgagc gtttcgtgtc taaggccggc aagtccaact 660 accagctgtg gcacgagctg tgcgacctca tctcccagaa tccggacaag gtacagtccc 720 tcaatgtgga cgccatcatc cgcgggggcc tcacccgctt caccgaccag ctgggcaagc 780 tctggtgttc tctcgccgac tactacatcc gcagcggcca tttcgagaag gctcgggacg 840 tgtacgagga ggccatccgg acagtgatga ccgtgcggga cttcacacag gtgtttgaca 900 gctacgccca gttcgaggag agcatgatcg ctgcaaagat ggagaccgcc tcggagctgg 960 ggcgcgagga ggaggatgat gtggacctgg agctgcgcct ggcccgcttc gagcagctca 1020 tcagccggcg gcccctgctc ctcaacagcg tcttgctgcg ccaaaaccca caccacgtgc 1080 acgagtggca caagcgtgtc gccctgcacc agggccgccc ccgggagatc atcaacacct 1140 acacagaggc tgtgcagacg gtggacccct tcaaggccac aggcaagccc cacactctgt 1200 gggtggcgtt tgccaagttt tatgaggaca acggacagct ggacgatgcc cgtgtcatcc 1260 tggagaaggc caccaaggtg aacttcaagc aggtggatga cctggcaagc gtgtggtgtc 1320 agtgcggaga gctggagctc cgacacgaga actacgatga ggccttgcgg ctgctgcgaa 1380 aggccacggc gctgcctgcc cgccgggccg agtactttga tggttcagag cccgtgcaga 1440 accgcgtgta caagtcactg aaggtctggt ccatgctcgc cgacctggag gagagcctcg 1500 gcaccttcca gtccaccaag gccgtgtacg accgcatcct ggacctgcgt atcgcaacac 1560 cccagatcgt catcaactat gccatgttcc tggaggagca caagtacttc gaggagagct 1620 tcaaggcgta cgagcgcggc atctcgctgt tcaagtggcc caacgtgtcc gacatctgga 1680 gcacctacct gaccaaattc attgcccgct atgggggccg caagctggag cgggcacggg 1740 acctgtttga acaggctctg gacggctgcc ccccaaaata tgccaagacc ttgtacctgc 1800 tgtacgcaca gctggaggag gagtggggcc tggcccggca tgccatggcc gtgtacgagc 1860 gtgccaccag ggccgtggag cccgcccagc agtatgacat gttcaacatc tacatcaagc 1920 gggcggccga gatctatggg gtcacccaca cccgcggcat ctaccagaag gccattgagg 1980 tgctgtcgga cgagcacgcg cgtgagatgt gcctgcggtt tgcagacatg gagtgcaagc 2040 tcggggagat tgaccgcgcc cgggccatct acagcttctg ctcccagatc tgtgaccccc 2100 ggacgaccgg cgcgttctgg cagacgtgga aggactttga ggtccggcat ggcaatgagg 2160 acaccatcaa ggaaatgctg cgtatccggc gcagcgtgca ggccacgtac aacacgcagg 2220 tcaacttcat ggcctcgcag atgctcaagg tctcgggcag tgccacgggc accgtgtctg 2280 acctggcccc tgggcagagt ggcatggacg acatgaagct gctggaacag cgggcagagc 2340 agctggcggc tgaggcggag cgtgaccagc ccttgcgcgc ccagagcaag atcctgttcg 2400 tgaggagtga cgcctcccgg gaggagctgg cagagctggc acagcaggtc aaccccgagg 2460 agatccagct gggcgaggac gaggacgagg acgagatgga cctggagccc aacgaggttc 2520 ggctggagca gcagagcgtg ccagccgcag tgtttgggag cctgaaggaa gactgacccg 2580 tccctccccc atcccccctc cccaccccct ccccaataca gctacgtttg tacatcaaaa 2640 aaaaaaaaaa aaaaaaaaaa aaaa 2664 <210> 409 <211> 2659 <212> DNA <213> Homo sapiens <400> 409 ggtacctggg catccagaaa aatggtggtg atggcgcgac tctcgcggcc cgagcggccg 60 gaccttgtct tcgaggaaga ggacctcccc tatgaggagg aaatcatgcg gaaccaattc 120 tctgtcaaat gctggcttcg ctacatcgag ttcaaacagg gcgccccgaa gcccaggctc 180 aatcagctat acgagcgggc actcaagctg ctgccctgca gctacaaact ctggtaccga 240 tacctgaagg cgcgtcgggc acaggtgaag catcgctgtg tgaccgaccc tgcctatgaa 300 gatgtcaaca actgtcatga gagggccttt gtgttcatgc acaagatgcc tcgtctgtgg 360 ctagattact gccagttcct catggaccag gggcgcgtca cacacacccg ccgcaccttc 420 gaccgtgccc tccgggcact gcccatcacg cagcactctc gaatttggcc cctgtatctg 480 cgcttcctgc gctcacaccc actgcctgag acagctgtgc gaggctatcg gcgcttcctc 540 aagctgagtc ctgagagtgc agaggagtac attgagtacc tcaagtcaag tgaccggctg 600 gatgaggccg cccagcgcct ggccaccgtg gtgaacgacg agcgtttcgt gtctaaggcc 660 ggcaagtcca actaccagct gtggcacgag ctgtgcgacc tcatctccca gaatccggac 720 aaggtacagt ccctcaatgt ggacgccatc atccgcgggg gcctcacccg cttcaccgac 780 cagctgggca agctctggtg ttctctcgcc gactactaca tccgcagcgg ccatttcgag 840 aaggctcggg acgtgtacga ggaggccatc cggacagtga tgaccgtgcg ggacttcaca 900 caggtgtttg acagctacgc ccagttcgag gagagcatga tcgctgcaaa gatggagacc 960 gcctcggagc tggggcgcga ggaggaggat gatgtggacc tggagctgcg cctggcccgc 1020 ttcgagcagc tcatcagccg gcggcccctg ctcctcaaca gcgtcttgct gcgccaaaac 1080 ccacaccacg tgcacgagtg gcacaagcgt gtcgccctgc accagggccg cccccgggag 1140 atcatcaaca cctacacaga ggctgtgcag acggtggacc ccttcaaggc cacaggcaag 1200 ccccacactc tgtgggtggc gtttgccaag ttttatgagg acaacggaca gctggacgat 1260 gcccgtgtca tcctggagaa ggccaccaag gtgaacttca agcaggtgga tgacctggca 1320 agcgtgtggt gtcagtgcgg agagctggag ctccgacacg agaactacga tgaggccttg 1380 cggctgctgc gaaaggccac ggcgctgcct gcccgccggg ccgagtactt tgatggttca 1440 gagcccgtgc agaaccgcgt gtacaagtca ctgaaggtct ggtccatgct cgccgacctg 1500 gaggagagcc tcggcacctt ccagtccacc aaggccgtgt acgaccgcat cctggacctg 1560 cgtatcgcaa caccccagat cgtcatcaac tatgccatgt tcctggagga gcacaagtac 1620 ttcgaggaga gcttcaaggc gtacgagcgc ggcatctcgc tgttcaagtg gcccaacgtg 1680 tccgacatct ggagcaccta cctgaccaaa ttcattgccc gctatggggg ccgcaagctg 1740 gagcgggcac gggacctgtt tgaacaggct ctggacggct gccccccaaa atatgccaag 1800 accttgtacc tgctgtacgc acagctggag gaggagtggg gcctggcccg gcatgccatg 1860 gccgtgtacg agcgtgccac cagggccgtg gagcccgccc agcagtatga catgttcaac 1920 atctacatca agcgggcggc cgagatctat ggggtcaccc acacccgcgg catctaccag 1980 aaggccattg aggtgctgtc ggacgagcac gcgcgtgaga tgtgcctgcg gtttgcagac 2040 atggagtgca agctcgggga gattgaccgc gcccgggcca tctacagctt ctgctcccag 2100 atctgtgacc cccggacgac cggcgcgttc tggcagacgt ggaaggactt tgaggtccgg 2160 catggcaatg aggacaccat caaggaaatg ctgcgtatcc ggcgcagcgt gcaggccacg 2220 tacaacacgc aggtcaactt catggcctcg cagatgctca aggtctcggg cagtgccacg 2280 ggcaccgtgt ctgacctggc ccctgggcag agtggcatgg acgacatgaa gctgctggaa 2340 cagcgggcag agcagctggc ggctgaggcg gagcgtgacc agcccttgcg cgcccagagc 2400 aagatcctgt tcgtgaggag tgacgcctcc cgggaggagc tggcagagct ggcacagcag 2460 gtcaaccccg aggagatcca gctgggcgag gacgaggacg aggacgagat ggacctggag 2520 cccaacgagg ttcggctgga gcagcagagc gtgccagccg cagtgtttgg gagcctgaag 2580 gaagactgac ccgtccctcc cccctcccca ccccctcccc aatacagcta cgtttgtaaa 2640 aaaaaaaaaa aaaaaaaaa 2659 <210> 410 <211> 2656 <212> DNA <213> Homo sapiens <400> 410 tgggcatcca gaaaaatggt ggtgatggcg cgactctcgc ggcccgagcg gccggacctt 60 gtcttcgagg aagaggacct cccctatgag gaggaaatca tgcggaacca attctctgtc 120 aaatgctggc ttcgctacat cgagttcaaa cagggcgccc cgaagcccag gctcaatcag 180 ctatacgagc gggcactcaa gctgctgccc tgcagctaca aactctggta ccgatacctg 240 aaggcgcgtc gggcacaggt gaagcatcgc tgtgtgaccg accctgccta tgaagatgtc 300 aacaactgtc atgagagggc ctttgtgttc atgcacaaga tgcctcgtct gtggctagat 360 tactgccagt tcctcatgga ccaggggcgc gtcacacaca cccgccgcac cttcgaccgt 420 gccctccggg caatgcccat cacgcagcac tctcgaattt ggcccctgta tctgcgcttc 480 ctgcgctcac acccactgcc tgagacagct gtgcgaggct atcggcgctt cctcaagctg 540 agtcctgaga gtgcagagga gtacattgag tacctcaagt caagtgaccg gctggatgag 600 gccgcccagc gcctggccac cgtggtgaac gacgagcgtt tcgtgtctaa ggccggcaag 660 tccaactacc agctgtggca cgagctgtgc gacctcatct cccagaatcc ggacaaggta 720 cagtccctca atgtggacgc catcatccgc gggggcctca cccgcttcac cgaccagctg 780 ggcaagctct ggtgttctct cgccgactac tacatccgca gcggccattt cgagaaggct 840 cgggacgtgt acgaggaggc catccggaca gtgatgaccg tgcgggactt cacacaggtg 900 tttgacagct acgcccagtt cgaggagagc atgatcgctg caaagatgga gaccgcctcg 960 gagctggggc gcgaggagga ggatgatgtg gacctggagc tgcgcctggc ccgcttcgag 1020 cagctcatca gccggcggcc cctgctcctc aacagcgtct tgctgcgcca aaacccacac 1080 cacgtgcacg agtggcacaa gcgtgtcgcc ctgcaccagg gccgcccccg ggagatcatc 1140 aacacctaca cagaggctgt gcagacggtg gaccccttca aggccacagg caagccccac 1200 actctgtggg tggcgtttgc caagttttat gaggacaacg gacagctgga cgatgcccgt 1260 gtcatcctgg agaaggccac caaggtgaac ttcaagcagg tggatgacct ggcaagcgtg 1320 tggtgtcagt gcggagagct ggagctccga cacgagaact acgatgaggc cttgcggctg 1380 ctgcgaaagg ccacggcgct gcctgcccgc cgggccgagt actttgatgg ttcagagccc 1440 gtgcagaacc gcgtgtacaa gtcactgaag gtctggtcca tgctcgccga cctggaggag 1500 agcctcggca ccttccagtc caccaaggcc gtgtacgacc gcatcctgga cctgcgtatc 1560 gcaacacccc agatcgtcat caactatgcc atgttcctgg aggagcacaa gtacttcgag 1620 gagagcttca aggcgtacga gcgcggcatc tcgctgttca agtggcccaa cgtgtccgac 1680 atctggagca cctacctgac caaattcatt gcccgctatg ggggccgcaa gctggagcgg 1740 gcacgggacc tgtttgaaca ggctctggac ggctgccccc caaaatatgc caagaccttg 1800 tacctgctgt acgcacagct ggaggaggag tggggcctgg cccggcatgc catggccgtg 1860 tacgagcgtg ccactagggc cgtggagccc gcccagcagt atgacatgtt caacatctac 1920 atcaagcggg cggccgagat ctatggggtc acccacaccc gcggcatcta ccagaaggcc 1980 attgaggtgc tgtcggacga gcacgcgcgt gagatgtgcc tgcggtttgc agacatggag 2040 tgcaagctcg gggagattga ccgcgcccgg gccatctaca gcttctgctc ccagatctgt 2100 gacccccgga cgaccggcgc gttctggcag acgtggaagg actttgaggt ccggcatggc 2160 aatgaggaca ccatcaagga aatgctgcgt atccggcgca gcgtgcaggc cacgtacaac 2220 acgcaggtca acttcatggc ctcgcagatg ctcaaggtct cgggcagtgc cacgggcacc 2280 gtgtctgacc tggcccctgg gcagagtggc atggacgaca tgaagctgct ggaacagcgg 2340 gcagagcagc tggcggctga ggcggagcgt gaccagccct tgcgcgccca gagcaagatc 2400 ctgttcgtga ggagtgacgc ctcccgggag gagctggcag agctggcaca gcaggtcaac 2460 cccgaggaga tccagctggg cgaggacgag gacgaggacg agatggacct ggagcccaac 2520 gaggttcggc tggagcagca gagcgtgcca gccgcagtgt ttgggagcct gaaggaagac 2580 tgacccgtcc ctcccccatc ccccctcccc accccctccc caatacagct acgtttgtaa 2640 aaaaaaaaaa aaaaaa 2656 <210> 411 <211> 2330 <212> DNA <213> Homo sapiens <400> 411 agagggcctt tgtgttcatg cacaagatgc ctcgtctgtg gctagattac tgccagttcc 60 tcatggacca ggggcgcgtc acacacaccc gccgcacctt cgaccgtgcc ctccgggcac 120 tgcccatcac gcagcactct cgaatttggc ccctgtatct gcgcttcctg cgctcacacc 180 cactgcctga gacagctgtg cgaggctatc ggcgcttcct caagctgagt cctgagagtg 240 cagaggagta cattgagtac ctcaagtcaa gtgaccggct ggatgaggcc gcccagcgcc 300 tggccaccgt ggtgaacgac gagcgtttcg tgtctaaggc cggcaagtcc aactaccagc 360 tgtggcacga gctgtgcgac ctcatctccc agaatccgga caaggtacag tccctcaatg 420 tggacgccat catccgcggg ggcctcaccc gcttcaccga ccagctgggc aagctctggt 480 gttctctcgc cgactactac atccgcagcg gccatttcga gaaggctcgg gacgtgtacg 540 aggaggccat ccggacagtg atgaccgtgc gggacttcac acaggtgttt gacagctacg 600 cccagttcga ggagagcatg atcgctgcaa agatggagac cgcctcggag ctggggcgcg 660 aggaggagga tgatgtggac ctggagctgc gcctggcccg cttcgagcag ctcatcagcc 720 ggcggcccct gctcctcaac agcgtcttgc tgcgccaaaa cccacaccac gtgcacgagt 780 ggcacaagcg tgtcgccctg caccagggcc gcccccggga gatcatcaac acctacacag 840 aggctgtgca gacggtggac cccttcaagg ccacaggcaa gccccacact ctgtgggtgg 900 cgtttgccaa gttttatgag gacaacggac agctggacga tgcccgtgtc atcctggaga 960 aggccaccaa ggtgaacttc aagcaggtgg atgacctggc aagcgtgtgg tgtcagtgcg 1020 gagagctgga gctccgacac gagaactacg atgaggcctt gcggctgctg cgaaaggcca 1080 cggcgctgcc tgcccgccgg gccgagtact ttgatggttc agagcccgtg cagaaccgcg 1140 tgtacaagtc actgaaggtc tggtccatgc tcgccgacct ggaggagagc ctcggcacct 1200 tccagtccac caaggccgtg tacgaccgca tcctggacct gcgtatcgca acaccccaga 1260 tcgtcatcaa ctatgccatg ttcctggagg agcacaagta cttcgaggag agcttcaagg 1320 cgtacgagcg cggcatctcg ctgttcaagt ggcccaacgt gtccgacatc tggagcacct 1380 acctgaccaa attcattgcc cgctatgggg gccgcaagct ggagcgggca cgggacctgt 1440 ttgaacaggc tctggacggc tgccccccaa aatatgccaa gaccttgtac ctgctgtacg 1500 cacagctgga ggaggagtgg ggcctggccc ggcatgccat ggccgtgtac gagcgtgcca 1560 ccagggccgt ggagcccgcc cagcagtatg acatgttcaa catctacatc aagcgggcgg 1620 ccgagatcta tggggtcacc cacacccgcg gcatctacca gaaggccatt gaggtgctgt 1680 cggacgagca cgcgcgtgag atgtgcctgc ggtttgcaga catggagtgc aagctcgggg 1740 agattgaccg cgcccgggcc atctacagct tctgctccca gatctgtgac ccccggacga 1800 ccggcgcgtt ctggcagacg tggaaggact ttgaggtccg gcatggcaat gaggacacca 1860 tcaaggaaat gctgcgtatc cggcgcagcg tgcaggccac gtacaacacg caggtcaact 1920 tcatggcctc gcagatgctc aaggtctcgg gcagtgccac gggcaccgtg tctgacctgg 1980 cccctgggca gagtggcatg gacgacatga agctgctgga acagcgggca gagcagctgg 2040 cggctgaggc ggagcgtgac cagcccttgc gcgcccagag caagatcctg ttcgtgagga 2100 gtgacgcctc ccgggaggag ctggcagagc tggcacagca ggtcaacccc gaggagatcc 2160 agctgggcga ggacgaggac gaggacgaga tggacctgga gcccaacgag gttcggctgg 2220 agcagcagag cgtgccagcc gcagtgtttg ggagcctgaa ggaagactga cccgtccctc 2280 ccccatcccc cctccccacc ccctccccaa tacagctacg tttgtacatc 2330 <210> 412 <211> 2002 <212> DNA <213> Homo sapiens <400> 412 ggcacgaggg ctgtgcgacc tcatctccca gaatccggac aaggtacagt ccctcaatgt 60 ggacgccatc atccgcgggg gcctcacccg cttcaccgac cagctgggca agctctggtg 120 ttctctcgcc gactactaca tccgcagcgg ccatttcgag aaggctcggg acgtgtacga 180 ggaggccatc cggacagtga tgaccgtgcg ggacttcaca caggtgtttg acagctacgc 240 ccagttcgag gagagcatga tcgctgcaaa gatggagacc gcctcggagc tggggcgcga 300 ggaggaggat gatgtggacc tggagctgcg cctggcccgc ttcgagcagc tcatcagccg 360 gcggcccctg ctcctcaaca gcgtcttgct gcgccaaaac ccacaccacg tgcacgagtg 420 gcacaagcgt gtcgccctgc accagggccg cccccgggag atcatcaaca cctacacaga 480 ggctgtgcag acggtggacc ccttcaaggc cacaggcaag ccccacactc tgtgggtggc 540 gtttgccaag ttttatgagg acaacggaca gctggacgat gcccgtgtca tcctggagaa 600 ggccaccaag gtgaacttca agcaggtgga tgacctggca agcgtgtggt gtcagtgcgg 660 agagctggag ctccgacaca agaactacga tgaggccttg cggctgctgc gaaaggccac 720 ggcgctgcct gcccgccggg ccgagtactt tgatggttca gagcccgtgc agaaccgcgt 780 gtacaagtca ctgaaggtct ggtccatgct cgccgacctg gaggagagcc tcggcacctt 840 ccagtccacc aaggccgtgt acgaccgcat cctggacctg cgtatcgcaa caccccagat 900 cgtcatcaac tatgccatgt tcctggagga gcacaagtac ttcgaggaga gcttcaaggc 960 gtacgagcgc ggcatctcgc tgttcaagtg gcccaacgtg tccgacatct ggagcaccta 1020 cctgaccaaa ttcattgccc gctatggggg ccgcaagctg gagcgggcac gggacctgtt 1080 tgaacaggct ctggacggct gccccccaaa atatgccaag accttgtacc tgctgtacgc 1140 acagctggag gaggagtggg gcctggcccg gcatgccatg gccgtgtacg agcgtgccac 1200 tagggccgtg gagcccgccc agcagtatga catgttcaac atctacatca agcgggcggc 1260 cgagatctat ggggtcaccc acacccgcgg catctaccag aaggccattg aggtgctgtc 1320 ggacgagcac gcgcgtgaga tgtgcctgcg gtttgcagac atggagtgca agctcgggga 1380 gattgaccgc gcccgggcca tctacagctt ctgctcccag atctgtgacc cccggacgac 1440 cggcgcgttc tggcagacgt ggaaggactt tgaggtccgg catggcaatg aggacaccat 1500 caaggaaatg ctgcgtatcc ggcgcagcgt gcaggccacg tacaacacgc aggtcaactt 1560 catggcctcg cagatgctca aggtctcggg cagtgccacg ggcaccgtgt ctgacctggc 1620 ccctgggcag agtggcatgg acgacatgaa gctgctggaa cagcgggcag agcagctggc 1680 ggctgaggcg gagcgtgacc agcccttgcg cgcccagagc aagatcctgt tcgtgaggag 1740 tgacgcctcc cgggaggagc tggcagagct ggcacagcag gtcaaccccg aggagatcca 1800 gctgggcgag gacgaggacg aggacgagat ggacctggag cccaacgagg ttcggctgga 1860 gcagcagagc gtgccagccg cagtgtttgg gagcctgaag gaagactgac ccatccctcc 1920 cccatccccc ctccccaccc cctccccaat acagctacgt ttgtacaaaa aaaaaaaaaa 1980 aaaaaaaaaa aaaaaaaaaa aa 2002 <210> 413 <211> 1947 <212> DNA <213> Homo sapiens <400> 413 atccggacaa ggtacagtcc ctcaatgtgg acgccatcat ccgcgggggc ctcacccgct 60 tcaccgacca gctgggcaag ctctggtgtt ctctcgccga ctactacatc cgcagcggcc 120 atttcgagaa ggctcgggac gtgtacgagg aggccatccg gacagtgatg accgtgcggg 180 acttcacaca ggtgtttgac agctacgccc agttcgagga gagcatgatc gctgcaaaga 240 tggagaccgc ctcggagctg gggcgcgagg aggaggatga tgtggacctg gagctgcgcc 300 tggcccgctt cgagcagctc atcagccggc ggcccctgct cctcaacagc gtcttgctgc 360 gccaaaaccc acaccacgtg cacgagtggc acaagcgtgt cgccctgcac cagggccgcc 420 cccgggagat catcaacacc tacacagagg ctgtgcagac ggtggacccc ttcaaggcca 480 caggcaagcc ccacactctg tgggtggcgt ttgccaagtt ttatgaggac aacggacagc 540 tggacgatgc ccgtgtcatc ctggagaagg ccaccaaggt gaacttcaag caggtggatg 600 acctggcaag cgtgtggtgt cagtgcggag agctggagct ccgacacgag aactacgatg 660 aggccttgcg gctgctgcga aaggccacgg cgctgcctgc ccgccgggcc gagtactttg 720 atggttcaga gcccgtgcag aaccgcgtgt acaagtcact gaaggtctgg tccatgctcg 780 ccgacctgga ggagagcctc ggcaccttcc agtccaccaa ggccgtgtac gaccgcatcc 840 tggacctgcg tatcgcaaca ccccagatcg tcatcaacta tgccatgttc ctggaggagc 900 acaagtactt cgaggagagc ttcaaggcgt acgagcgcgg catctcgctg ttcaagtggc 960 ccaacgtgtc cgacatctgg agcacctacc tgaccaaatt cattgcccgc tatgggggcc 1020 gcaagctgga gcgggcacgg gacctgtttg aacaggctct ggacggctgc cccccaaaat 1080 atgccaagac cttgtacctg ctgtacgcac agctggagga ggagtggggc ctggcccggc 1140 atgccatggc cgtgtacgag cgtgccacca gggccgtgga gcccgcccag cagtatgaca 1200 tgttcaacat ctacatcaag cgggcggccg agatctatgg ggtcacccac acccgcggca 1260 tctaccagaa ggccattgag gtgctgtcgg acgagcacgc gcgtgagatg tgcctgcggt 1320 ttgcagacat ggagtgcaag ctcggggaga ttgaccgcgc ccgggccatc tacagcttct 1380 gctcccagat ctgtgacccc cggacgaccg gcgcgttctg gcagacgtgg aaggactttg 1440 aggtccggca tggcaatgag gacaccatca aggaaatgct gcgtatccgg cgcagcgtgc 1500 aggccacgta caacacgcag gtcaacttca tggcctcgca gatgctcaag gtctcgggca 1560 gtgccacggg caccgtgtct gacctggccc ctgggcagag tggcatggac gacatgaagc 1620 tgctggaaca gcgggcagag cagctggcgg ctgaggcgga gcgtgaccag cccttgcgcg 1680 cccagagcaa gatcctgttc gtgaggagtg acgcctcccg ggaggagctg gcagagctgg 1740 cacagcaggt caaccccgag gagatccagc tgggcgagga cgaggacgag gacgagatgg 1800 acctggagcc caacgaggtt cggctggagc agcagagcgt gccagccgca gtgtttggga 1860 gcctgaagga agactgaccc gtccctcccc cctccccacc ccctccccaa tacagctacg 1920 tttgtacatc aaaaaaaaaa aaaaaaa 1947 <210> 414 <211> 4555 <212> DNA <213> Homo sapiens <400> 414 aaatcatgcg gaaccaattc tctgtcaaat gctggcttcg ctacatcgag ttcaaacagg 60 gcgccccgaa gcccaggctc aatcagctat acgagcgggc actcaagctg ctgccctgca 120 ggtgggaatg gctccagctg ccctgcccac cagcccccac cccacctggt ccagttataa 180 caaaactgcc aagtgggtcc cgggtcccgg gtgattgctt cgtgtttcat cactgacctg 240 tacatccctt gatgggtcag cacaccttct ctgatgtccc agtctgtccc tgtcattgct 300 gagacatgtc acccctccca caccccttct tcccacattt gccaactggg gcagggcaaa 360 tggttctggg ggtgtccata aagctgaccg atcagcatct gtcccctcct attccccagc 420 tacaaactct ggtaccgata cctgaaggcg cgtcgggcac aggtgaagca tcgctgtgtg 480 accgaccctg cctatgaaga tgtcaacaac tgtcatgaga gggcctttgt gttcatgcac 540 aaggtttggg gctcggcgag gggatgaatc gggaagtgga gctcagtcca tggtggtggg 600 tggggcgggg acaggggctg ggctcagcat gttagggatg ggggcttgga ttcctgttgc 660 ttctttgcat gggaagttgg gctggactca gtcctggagc tgggggtttc tgggtcccgc 720 cgcatttatg tggtggcccc aggtgtggct cagccacagg acatcgagtg tctgtggcca 780 ggccatggag tccgtggctt agccccagcc gcctctcccc acacccccag atgcctcgtc 840 tgtggctaga ttactgccag ttcctcatgg accaggggcg cgtcacacac acccgccgca 900 ccttcgaccg tgccctccgg gcactgccca tcacgcagca ctctcgaatt tggcccctgt 960 atctgcgctt cctgcgctca cacccactgc ctgagacagc tgtgcgaggc tatcggcgct 1020 tcctcaagct gagtcctgag agtgcagagg agtacattga gtacctcaag tcaagtgacc 1080 ggctggatga ggccgcccag cgcctggcca ccgtggtgaa cgacgagcgt ttcgtgtcta 1140 aggccggcaa gtccaactac caggtgggcc tgccgggagc cggcaactgg gtgggagggc 1200 caccccctcc atgactgagc ctgagactct cccccactgc cccatgccct gcagctgtgg 1260 cacgagctgt gcgacctcat ctcccagaat ccggacaagg tacagtccct caatgtggac 1320 gccatcatcc gcgggggcct cacccgcttc accgaccagc tgggcaagct ctggtgttct 1380 ctcgccgact actacatccg cagcggccat ttcgagaagg ctcgggacgt gtacgaggag 1440 gccatccgga cagtgatgac cgtgcgggac ttcacacagg tgtttgacag ctacgcccag 1500 ttcgaggaga gcatgatcgc tgcaaagatg gagaccgcct cggagctggg gcgcgaggag 1560 gaggatgatg tggacctgga gctgcgcctg gcccgcttcg agcagctcat cagccggcgg 1620 cccctgctcc tcaacagcgt cttgctgcgc caaaacccac accacgtgca cgagtggcac 1680 aagcgtgtcg ccctgcacca gggccgcccc cgggagatca tcaacaccta cacagaggct 1740 gtgcagacgg tggacccctt caaggccaca ggcaagcccc acactctgtg ggtggcgttt 1800 gccaagtttt atgaggacaa cggacagctg gacgatgccc gtgtcatcct ggagaaggcc 1860 accaaggtga acttcaagca ggtggatgac ctggcaagcg tgtggtgtca gtgcggagag 1920 ctggagctcc gacacgagaa ctacgatgag gccttgcggc tgctgcgaaa ggccacggcg 1980 ctgcctgccc gccgggccga gtactttgat ggttcagagc ccgtgcagaa ccgcgtgtac 2040 aagtcactga aggtctggtc catgctcgcc gacctggagg agagcctcgg caccttccag 2100 tccaccaagg ccgtgtacga ccgcatcctg gacctgcgta tcgcaacacc ccagatcgtc 2160 atcaactatg ccatgttcct ggaggagcac aagtacttcg aggagagctt caaggtgagg 2220 ggctagggtg gacccagagg cccctgatgg cagtgtcccc tccccagggg tcctcagcaa 2280 cttacgaatc tgctggggct tgtgtgacac agtatacaga ctgggtgact taaacaacaa 2340 agatttagct tctccccgtc ctggaggctg gaagtccagg atcgaggcat gggcagggct 2400 ggttcctcct gaggcctctc tccttagctt acagacagcc gccttctccc tatgtctttg 2460 tgtggccttc tctttgtgtg tgtcactttt gaaatttcct cttcttataa aggacatcag 2520 tcataatgga ttaggtggcc cctaacgacc tcagtttaac ttagtgatct catcttcaaa 2580 cgaatctact ttctgaggta ctgggggtta agatttgagc atatgaatgt tttgaggggg 2640 gcacagttca ttccatagca ggcacagagt cctacttcca cgtgcaccca tgactcatgg 2700 ggagggtgtt ggtgccagtg tgtgcgggct ctccctgccc cgctgctcag gagacgggtt 2760 gtggggtcca gggggtgggt tgcgtgtccg tgggaaggcc atgtcccgcg gccggagcag 2820 tcatgtttga gtgtgtgttt ctatggatcg tgtgggcatt atacagatac acaaatgggg 2880 aggtcgtaca tgcatacgcg tgctactgcc tgcccctctg tcagggggtg cggccttctc 2940 cctggggaca ggcagccagc gtcagcggag ctggggagcc acccaccttc acccatcatg 3000 tcacctccta tggggccaga ctgtgcttag caggtcccat tgcacccctg ttcttggggt 3060 tctcacagag ggagacagtg cagaggacag acccccacaa ctgccattag ggacagggag 3120 gcgtggacag ggaagggccc caagggagtt cctggcaggc tccctacaga cgccacccaa 3180 ggacatcccg ggtgcctggt ggtctctatc tgcagactct cacatgtgac tctccctctg 3240 gtaacaggcg tacgagcgcg gcatctcgct gttcaagtgg cccaacgtgt ccgacatctg 3300 gagcacctac ctgaccaaat tcattgcccg ctatgggggc cgcaagctgg agcgggcacg 3360 ggacctgttt gaacaggctc tggacggctg ccccccaaaa tatgccaaga gtgaggcggg 3420 cagagggcat ggggggggtg gcgggcgggc tgggtttctg actggccccg gctgaccgtg 3480 ctcccctctc cccgcctacc ccgcccagcc ttgtacctgc tgtacgcaca gctggaggag 3540 gagtggggcc tggcccggca tgccatggcc gtgtacgagc gtgccaccag ggccgtggag 3600 cccgcccagc agtatgacat gttcaacatc tacatcaagc gggcggccga gatctatggg 3660 gtcacccaca cccgcggcat ctaccagaag gccattgagg tgctgtcgga cgagcacgcg 3720 cgtgagatgt gcctgcggtt tgcagacatg gagtgcaagc tcggggagat tgaccgcgcc 3780 cgggccatct acagcttctg ctcccagatc tgtgaccccc gggtagggct gtggggaggg 3840 acgggtatca gggttggggg ctgcggcgga gtcagccagc tcacgggcac acacacccac 3900 ccctgccctg ccccccacgc agacgaccgg cgcgttctgg cagacgtgga aggactttga 3960 ggtccggcat ggcaatgagg acaccatcaa ggaaatgctg cgtatccggc gcagcgtgca 4020 ggccacgtac aacacgcagg tcaacttcat ggcctcgcag atgctcaagg tctcgggcag 4080 tgccacgggc accgtgtctg acctggcccc tgggcagagt ggcatggacg acatgaagct 4140 gctggaacag cgggcagagc agctggcggc tgaggcggag cgtgaccagc ccttgcgcgc 4200 ccagagcaag atcctgttcg tgaggagtga cgcctcccgg gaggagctgg cagagctggc 4260 acagcaggtc aaccccgagg agatccagct gggcgaggac gaggacgagg acgagatgga 4320 cctggagccc aacggtgagg gcccggctgg ggcggggacg gtggcattac cagggtgggc 4380 ctcgggggac aggccaacgc caggagggtg actggctccc gccttcccca cagaggttcg 4440 gctggagcag cagagcgtgc cagccgcagt gtttgggagc ctgaaggaag actgacccgt 4500 ccctccccca tcccccctcc ccaccccctc cccaatacag ctacgtttgt acatc 4555 <210> 415 <211> 2058 <212> DNA <213> Homo sapiens <400> 415 ccagcccgtc tccccgctcc agtttagaac ctaattccca attcccggac cgggcccagc 60 cctgggctct tactgtccgc ttttgctggg acctgttcca caaatgggcg tcttctgcct 120 tgggccgtgg gggttgggcc ggaagctgcg gacgcctggg aaggggccgc tgcagctctt 180 gagccgcctc tgcggggacc acttgcaggc catcccagcc aagaaggccc cggctgggca 240 ggaggagcct gggacgccgc cctcctcgcc gctgagtgcc gagcagttgg accggatcca 300 gaggaacaag gccgcggccc tgctcagact cgcggcccgc aacgtgcccg tgggctttgg 360 agagagctgg aagaagcacc tcagcgggga gttcgggaaa ccgtatttta tcaagctaat 420 gggatttgtt gcagaagaaa gaaagcatta cactgtttat ccacccccac accaagtctt 480 cacctggacc cagatgtgtg acataaaaga tgtgaaggtt gtcatcctgg gacaggatcc 540 atatcatgga cctaatcaag ctcacgggct ctgctttagt gttcaaaggc ctgttccgcc 600 tccgcccagt ttggagaaca tttataaaga gttgtctaca gacatagagg attttgttca 660 tcctggccat ggagatttat ctgggtgggc caagcaaggt gttctccttc tcaacgctgt 720 cctcacggtt cgtgcccatc aagccaactc tcataaggag cgaggctggg agcagttcac 780 tgatgcagtt gtgtcctggc taaatcagaa ctcgaatggc cttgttttct tgctctgggg 840 ctcttatgct cagaagaagg gcagtgccat tgataggaag cggcaccatg tactacagac 900 ggctcatccc tcccctttgt cagtgtatag agggttcttt ggatgtagac acttttcaaa 960 gaccaatgag ctgctgcaga agtctggcaa gaagcccatt gactggaagg agctgtgatc 1020 atcagctgag gggtggcctt tgagaagctg ctgttaacgt atttgccagt tacgaagttc 1080 cactgaaaat tttcctatta attcttaagt actctgcata agggggaaaa gcttccagaa 1140 agcagccatg aaccaggctg tccaggaatg gcagctgtat ccaaccacaa acaacaaagg 1200 ctaccctttg accaaatgtc tttctctgca acatggcttc ggcctaaaat atgcagaaga 1260 cagatgaggt caaatactca gttggctctc tttatctccc ttgcctttat ggtgaaacag 1320 gggagatgtg cacctttcag gcacagccct agtttggcgc ctgctgctcc ttggttttgc 1380 ctggttagac tttcagtgac agatgttggg gtgtttttgc ttagaaaggt ccccttgtct 1440 cagccttgca gggcaggcat gccagtctct gccagttcca ctgccccctt gatctttgaa 1500 ggagtcctca ggcccctcgc agcataagga tgttttgcaa ctttccagaa tctggcccag 1560 aaattagggc tcaatttcct gattgtagta gaggttaaga ttgctgtgag ctttatcaga 1620 taagagaccg agagaagtaa gctgggtctt gttattcctt gggtgttggt ggaataagca 1680 gtggaatttg aacaaggaag aggagaaaag ggaattttgt ctttatgggg tggggtgatt 1740 ttctcctagg gttatgtcca gttggggttt ttaaggcagc acagactgcc aagtactgtt 1800 ttttttaacc gactgaaatc actttgggat attttttcct gcaacactgg aaagttttag 1860 ttttttaaga agtactcatg cagatatata tatatatatt tttcccagtc ctttttttaa 1920 gagacggtct ttattgggtc tgcacctcca tccttgatct tgttagcaat gctgtttttg 1980 ctgttagtcg ggttagagtt ggctctacgc gaggtttgtt aataaaagtt tgttaaaagt 2040 taaaaaaaaa aaaaaaaa 2058 <210> 416 <211> 2081 <212> DNA <213> Homo sapiens <400> 416 tcgggaagcc atagggcgcc tcccagcccg tctccccgct ccagtttaga acctaattcc 60 caattcccgg accgggccca gccctgggct cttactgtcc gcttttgctg ggacctgttc 120 cacaaatggg cgtcttctgc cttgggccgt gggggttggg ccggaagctg cggacgcctg 180 ggaaggggcc gctgcagctc ttgagccgcc tctgcgggga ccacttgcag gccatcccag 240 ccaagaaggc cccggctggg caggaggagc ctgggacgcc gccctcctcg ccgctgagtg 300 ccgagcagtt ggaccggatc cagaggaaca aggccgcggc cctgctcaga ctcgcggccc 360 gcaacgtgcc cgtgggcttt ggagagagct ggaagaagca cctcagcggg gagttcggga 420 aaccgtattt tatcaagcta atgggatttg ttgcagaaga aagaaagcat tacactgttt 480 atccaccccc acaccaagtc ttcacctgga cccagatgtg tgacataaaa gatgtgaagg 540 ttgtcatcct gggacaggat ccatatcatg gacctaatca agctcacggg ctctgcttta 600 gtgttcaaag gcctgttccg cctccgccca gtttggagaa catttataaa gagttgtcta 660 cagacataga ggattttgtt catcctggcc atggagattt atctgggtgg gccaagcaag 720 gtgttctcct tctcaacgct gtcctcacgg ttcgtgccca tcaagccaac tctcataagg 780 agcgaggctg ggagcagttc actgatgcag ttgtgtcctg gctaaatcag aactcgaatg 840 gccttgtttt cttgctctgg ggctcttatg ctcagaagaa gggcagtgcc attgatagga 900 agcggcacca tgtactacag acggctcatc cctccccttt gtcagtgtat agagggttct 960 ttggatgtag acacttttca aagaccaatg agctgctgca gaagtctggc aagaagccca 1020 ttgactggaa ggagctgtga tcatcagctg aggggtggcc tttgagaagc tgctgttaac 1080 gtatttgcca gttacgaagt tccactgaaa attttcctat taattcttaa gtactctgca 1140 taagggggaa aagcttccag aaagcagcca tgaaccaggc tgtccaggaa tggcagctgt 1200 atccaaccac aaacaacaaa ggctaccctt tgaccaaatg tctttctctg caacatggct 1260 tcggcctaaa atatgcagaa gacagatgag gtcaaatact cagttggctc tctttatctc 1320 ccttgccttt atggtgaaac aggggagatg tgcacctttc aggcacagcc ctagtttggc 1380 gcctgctgct ccttggtttt gcctggttag actttcagtg acagatgttg gggtgttttt 1440 gcttagaaag gtccccttgt ctcagccttg cagggcaggc atgccagtct ctgccagttc 1500 cactgccccc ttgatctttg aaggagtcct caggcccctc gcagcataag gatgttttgc 1560 aactttccag aatctggccc agaaattagg gctcaatttc ctgattgtag tagaggttaa 1620 gattgctgtg agctttatca gataagagac cgagagaagt aagctgggtc ttgttattcc 1680 ttgggtgttg gtggaataag cagtggaatt tgaacaagga agaggagaaa agggaatttt 1740 gtctttatgg ggtggggtga ttttctccta gggttatgtc cagttggggt ttttaaggca 1800 gcacagactg ccaagtactg ttttttttaa ccgactgaaa tcactttggg atattttttc 1860 ctgcaacact ggaaagtttt agttttttaa gaagtactca tgcagatata tatatatata 1920 tttttcccag tccttttttt aagagacggt ctttattggg tctgcacctc catccttgat 1980 cttgttagca atgctgtttt tgctgttagt cgggttagag ttggctctac gcgaggtttg 2040 ttaataaaag tttgttaaaa gtttaaaaaa aaaaaaaaaa a 2081 <210> 417 <211> 2045 <212> DNA <213> Homo sapiens <400> 417 ccccgctcca gtttagaacc taattcccaa ttcccggacc gggcccagcc ctgggctctt 60 actgtccgct tttgctggga cctgttccac aaatgggcgt cttctgcctt gggccgtggg 120 ggttgggccg gaagctgcgg acgcctggga aggggccgct gcagctcttg agccgcctct 180 gcggggacca cttgcaggcc atcccagcca agaaggcccc ggctgggcag gaggagcctg 240 ggacgccgcc ctcctcgccg ctgagtgccg agcagttgga ccggatccag aggaacaagg 300 ccgcggccct gctcagactc gcggcccgca acgtgcccgt gggctttgga gagagctgga 360 agaagcacct cagcggggag ttcgggaaac cgtattttat caagctaatg ggatttgttg 420 cagaagaaag aaagcattac actgtttatc cacccccaca ccaagtcttc acctggaccc 480 agatgtgtga cataaaagat gtgaaggttg tcatcctggg acaggatcca tatcatggac 540 ctaatcaagc tcacgggctc tgctttagtg ttcaaaggcc tgttccgcct ccgcccagtt 600 tggagaacat ttataaagag ttgtctacag acatagagga ttttgttcat cctggccatg 660 gagatttatc tgggtgggcc aagcaaggtg ttctccttct caacgctgtc ctcacggttc 720 gtgcccatca agccaactct cataaggagc gaggctggga gcagttcact gatgcagttg 780 tgtcctggct aaatcagaac tcgaatggcc ttgttttctt gctctggggc tcttatgctc 840 agaagaaggg cagtgccatt gataggaagc ggcaccatgt actacagacg gctcatccct 900 cccctttgtc agtgtataga gggttctttg gatgtagaca cttttcaaag accaatgagc 960 tgctgcagaa gtctggcaag aagcccattg actggaagga gctgtgatca tcagctgagg 1020 ggtggccttt gagaagctgc tgttaacgta tttgccagtt acgaagttcc actgaaaatt 1080 ttcctattaa ttcttaagta ctctgcataa gggggaaaag cttccagaaa gcagccatga 1140 accaggctgt ccaggaatgg cagctgtatc caaccacaaa caacaaaggc taccctttga 1200 ccaaatgtct ttctctgcaa catggcttcg gcctaaaata tgcagaagac agatgaggtc 1260 aaatactcag ttggctctct ttatctccct tgcctttatg gtgaaacagg ggagatgtgc 1320 acctttcagg cacagcccta gtttggcgcc tgctgctcct tggttttgcc tggttagact 1380 ttcagtgaca gatgttgggg tgtttttgct tagaaaggtc cccttgtctc agccttgcag 1440 ggcaggcatg ccagtctctg ccagttccac tgcccccttg atctttgaag gagtcctcag 1500 gcccctcgca gcataaggat gttttgcaac tttccagaat ctggcccaga aattatggct 1560 caatttcctg attgtagtag aggttaagat tgctgtgagc tttatcagat aagagaccga 1620 gagaagtaag ctgggtcttg ttattccttg ggtgttggtg gaataagcag tggaatttga 1680 acaaggaaga ggagaaaagg gaattttgtc tttatggggt ggggtgattt tctcctaggg 1740 ttatgtccag ttggggtttt taaggcagca cagactgcca agtactgttt tttttaaccg 1800 actgaaatca ctttgggata ttttttcctg caacactgga aagttttagt tttttaagaa 1860 gtactcatgc agatatatat atatatattt ttcccagtcc tttttttaag agacggtctt 1920 tattgggtct gcacctccat ccttgatctt gttagcaatg ctgtttttgc tgttagtcgg 1980 gttagagttg gctctacgcg aggtttgtta ataaaagttt gttaaaagtt aaaaaaaaaa 2040 aaaaa 2045 <210> 418 <211> 2062 <212> DNA <213> Homo sapiens <400> 418 ctcccagccc gtctccccgc tccagtttag aacctaattc ccaattcccg gaccgggccc 60 agccctgggc tcttactgtc cgcttttgct gggacctgtt ccacaaatgg gcgtcttctg 120 ccttgggccg tgggggttgg gccggaagct gcggacgcct gggaaggggc cgctgcagct 180 cttgagccgc ctctgcgggg accacttgca ggccatccca gccaagaagg ccccggctgg 240 gcaggaggag cctgggacgc cgccctcctc gccgctgagt gccgagcagt tggaccggat 300 ccagaggaac aaggccgcgg ccctgctcag actcgcggcc cgcaacgtgc ccgtgggctt 360 tggagagagc tggaagaagc acctcagcgg ggagttcggg aaaccgtatt ttatcaagct 420 aatgggattt gttgcagaag aaagaaagca ttacactgtt tatccacccc cacaccaagt 480 cttcacctgg acccagatgt gtgacataaa agatgtgaag gttgtcatcc tgggacagga 540 tccatatcat ggacctaatc aagctcacgg gctctgcttt agtgttcaaa ggcctgttcc 600 gcctccgccc agtttggaga acatttataa agagttgtct acagacatag aggattttgt 660 tcatcctggc catggagatt tatctgggtg ggccaagcaa ggtgttctcc ttctcaacgc 720 tgtcctcacg gttcgtgccc atcaagccaa ctctcataag gagcgaggct gggagcagtt 780 cactgatgca gttgtgtcct ggctaaatca gaactcgaat ggccttgttt tcttgctctg 840 gggctcttat gctcagaaga agggcagtgc cattgatagg aagcggcacc atgtactaca 900 gacggctcat ccctcccctt tgtcagtgta tagagggttc tttggatgta gacacttttc 960 aaagaccaat gagctgctgc agaagtctgg caagaagccc attgactgga aggagctgtg 1020 atcatcagct gaggggtggc ctttgagaag ctgctgttaa cgtatttgcc agttacgaag 1080 ttccactgaa aattttccta ttaattctta agtactctgc ataaggggga aaagcttcca 1140 gaaagcagcc atgaaccagg ctgtccagga atggcagctg tatccaacca caaacaacaa 1200 aggctaccct ttgaccaaat gtctttctct gcaacatggc ttcggcctaa aatatgcaga 1260 agacagatga ggtcaaatac tcagttggct ctctttatct cccttgcctt tatggtgaaa 1320 caggggagat gtgcaccttt caggcacagc cctagtttgg cgcctgctgc tccttggttt 1380 tgcctggtta gactttcagt gacagatgtt ggggtgtttt tgcttagaaa ggtccccttg 1440 tctcagcctt gcagggcagg catgccagtc tctgccagtt ccactgcccc cttgatcttt 1500 gaaggagtcc tcaggcccct cgcagcataa ggatgttttg caactttcca gaatctggcc 1560 cagaaattag ggctcaattt cctgattgta gtagaggtta agattgctgt gagctttatc 1620 agataagaga ccgagagaag taagctgggt cttgttattc cttgggtgtt ggtggaataa 1680 gcagtggaat ttgaacaagg aagaggagaa aagggaattt tgtctttatg gggtggggtg 1740 attttctcct agggttatgt ccagttgggg tttttaaggc agcacagact gccaagtact 1800 gtttttttta accgactgaa atcactttgg gatatttttt cctgcaacac tggaaagttt 1860 tagtttttta agaagtactc atgcagatat atatatatat atttttccca gtcctttttt 1920 taagagacgg tctttattgg gtctgcacct ccatccttga tcttgttagc aatgctgttt 1980 ttgctgttag tcgggttaga gttggctcta cgcgaggttt gttaataaaa gtttgttaaa 2040 agttcaaaaa aaaaaaaaaa aa 2062 <210> 419 <211> 2053 <212> DNA <213> Homo sapiens <400> 419 cacagccaca gccagggcta gcctcgccgg ttcccgggtg gcgcgcgttc gctgcctcct 60 cagctccagg atgatcggcc agaagacgct ctactccttt ttctccccca gccccgccag 120 gaagcgacac gcccccagcc ccgagccggc cgtccagggg accggcgtgg ctggggtgcc 180 tgaggaaagc ggagatgcgg cggccatccc agccaagaag gccccggctg ggcaggagga 240 gcctgggacg ccgccctcct cgccgctgag tgccgagcag ttggaccgga tccagaggaa 300 caaggccgcg gccctgctca gactcgcggc ccgcaacgtg cccgtgggct ttggagagag 360 ctggaagaag cacctcagcg gggagttcgg gaaaccgtat tttatcaagc taatgggatt 420 tgttgcagaa gaaagaaagc attacactgt ttatccaccc ccacaccaag tcttcacctg 480 gacccagatg tgtgacataa aagatgtgaa ggttgtcatc ctgggacagg atccatatca 540 tggacctaat caagctcacg ggctctgctt tagtgttcaa aggcctgttc cgcctccgcc 600 cagtttggag aacatttata aagagttgtc tacagacata gaggattttg ttcatcctgg 660 ccatggagat ttatctgggt gggccaagca aggtgttctc cttctcaacg ctgtcctcac 720 ggttcgtgcc catcaagcca actctcataa ggagcgaggc tgggagcagt tcactgatgc 780 agttgtgtcc tggctaaatc agaactcgaa tggccttgtt ttcttgctct ggggctctta 840 tgctcagaag aagggcagtg ccattgatag gaagcggcac catgtactac agacggctca 900 tccctcccct ttgtcagtgt atagagggtt ctttggatgt agacactttt caaagaccaa 960 tgagctgctg cagaagtctg gcaagaagcc cattgactgg aaggagctgt gatcatcagc 1020 tgaggggtgg cctttgagaa gctgctgtta acgtatttgc cagttacgaa gttccactga 1080 aaattttcct attaattctt aagtactctg cataaggggg aaaagcttcc agaaagcagc 1140 catgaaccag gctgtccagg aatggcagct gtatccaacc acaaacaaca aaggctaccc 1200 tttgaccaaa tgtctttctc tgcaacatgg cttcggccta aaatatgcag aagacagatg 1260 aggtcaaata ctcagttggc tctctttatc tcccttgcct ttatggtgaa acaggggaga 1320 tgtgcacctt tcaggcacag ccctagtttg gcgcctgctg ctccttggtt ttgcctggtt 1380 agactttcag tgacagatgt tggggtgttt ttgcttagaa aggtcccctt gtctcagcct 1440 tgcagggcag gcatgccagt ctctgccagt tccactgccc ccttgatctt tgaaggagtc 1500 ctcaggcccc tcgcagcata aggatgtttt gcaactttcc agaatctggc ccagaaatta 1560 gggctcaatt tcctgattgt agtagaggtt aagattgctg tgagctttat cagataagag 1620 accgagagaa gtaagctggg tcttgttatt ccttgggtgt tggtggaata agcagtggaa 1680 tttgaacaag gaagaggaga aaagggaatt ttgtctttat ggggtggggt gattttctcc 1740 tagggttatg tccagttggg gtttttaagg cagcacagac tgccaagtac tgtttttttt 1800 aaccgactga aatcactttg ggatattttt tcctgcaaca ctggaaagtt ttagtttttt 1860 aagaagtact catgcagata tatatatata tatttttccc agtccttttt ttaagagacg 1920 gtctttattg ggtctgcacc tccatccttg atcttgttag caatgctgtt tttgctgtta 1980 gtcgggttag agttggctct acgcgaggtt tgttaataaa agtttgttaa aagtttaaaa 2040 aaaaaaaaaa aaa 2053 <210> 420 <211> 2057 <212> DNA <213> Homo sapiens <400> 420 cacagccaca gccagggcta gcctcgccgg ttcccgggtg gcgcgcgttc gctgcctcct 60 cagctccagg atgatcggcc agaagacgct ctactccttt ttctccccca gccccgccag 120 gaagcgacac gcccccagcc ccgagccggc cgtccagggg accggcgtgg ctggggtgcc 180 tgaggaaagc ggagatgcgg cggccatccc agccaagaag gccccggctg ggcaggagga 240 gcctgggacg ccgccctcct cgccgctgag tgccgagcag ttggaccgga tccagaggaa 300 caaggccgcg gccctgctca gactcgcggc ccgcaacgtg cccgtgggct ttggagagag 360 ctggaagaag cacctcagcg gggagttcgg gaaaccgtat tttatcaagc taatgggatt 420 tgttgcagaa gaaagaaagc attacactgt ttatccaccc ccacaccaag tcttcacctg 480 gacccagatg tgtgacataa aagatgtgaa ggttgtcatc ctgggacagg atccatatca 540 tggacctaat caagctcacg ggctctgctt tagtgttcaa aggcctgttc cgcctccgcc 600 cagtttggag aacatttata aagagttgtc tacagacata gaggattttg ttcatcctgg 660 ccatggagat ttatctgggt gggccaagca aggtgttctc cttctcaacg ctgtcctcac 720 ggttcgtgcc catcaagcca actctcataa ggagcgaggc tgggagcagt tcactgatgc 780 agttgtgtcc tggctaaatc agaactcgaa tggccttgtt ttcttgctct ggggctctta 840 tgctcagaag aagggcagtg ccattgatag gaagcggcac catgtactac agacggctca 900 tccctcccct ttgtcagtgt atagagggtt ctttggatgt agacactttt caaagaccaa 960 tgagctgctg cagaagtctg gcaagaagcc cattgactgg aaggagctgt gatcatcagc 1020 tgaggggtgg cctttgagaa gctgctgtta acgtatttgc cagttacgaa gttccactga 1080 aaattttcct attaattctt aagtactctg cataaggggg aaaagcttcc agaaagcagc 1140 catgaaccag gctgtccagg aatggcagct gtatccaacc acaaacaaca aaggctaccc 1200 tttgaccaaa tgtctttctc tgcaacatgg cttcggccta aaatatgcag aagacagatg 1260 aggtcaaata ctcagttggc tctctttatc tcccttgcct ttatggtgaa acaggggaga 1320 tgtgcacctt tcaggcacag ccctagtttg gcgcctgctg ctccttggtt ttgcctggtt 1380 agactttcag tgacagatgt tggggtgttt ttgcttagaa aggtcccctt gtctcagcct 1440 tgcagggcag gcatgccagt ctctgccagt tccactgccc ccttgatctt tgaaggagtc 1500 ctcaggcccc tcgcagcata aggatgtttt gcaactttcc agaatctggc ccagaaatta 1560 gggctcaatt tcctgattgt agtagaggtt aagattgctg tgagctttat cagataagag 1620 accgagagaa gtaagctggg tcttgttatt ccttgggtgt tggtggaata agcagtggaa 1680 tttgaacaag gaagaggaga aaagggaatt ttgtctttat ggggtggggt gattttctcc 1740 tagggttatg tccagttggg gtttttaagg cagcacagac tgccaagtac tgtttttttt 1800 aaccgactga aatcactttg ggatattttt tcctgcaaca ctggaaagtt ttagtttttt 1860 aagaagtact catgcagata tatatatata tatttttccc agtccttttt ttaagagacg 1920 gtctttattg ggtctgcacc tccatccttg atcttgttag caatgctgtt tttgctgtta 1980 gtcgggttag agttggctct acgcgaggtt tgttaataaa agtttgttaa aagttcaaaa 2040 aaaaaaaaaa aaacccg 2057 <210> 421 <211> 2470 <212> DNA <213> Homo sapiens <400> 421 ggcggctgta gccgaggggg cggccggaaa gcagcggcgg cgtctggggc gctttcgcaa 60 cattcagacc tcggttgcag cccggtgccg tgagctgaag aggtttcaca tcttactccg 120 ccccacaccc tgggcgttgc ggcgctgggc tcgttgctgc agccggaccc tgctcgatgg 180 gcacgactgg gctggagagt ctgagtctgg gggaccgcgg agctgccccc accgtcacct 240 ctagtgagcg cctagtccca gacccgccga atgacctccg caaagaagat gttgctatgg 300 aattggaaag agtgggagaa gatgaggaac aaatgatgat aaaaagaagc agtgaatgta 360 atcccttgct acaagaaccc atcgcttctg ctcagtttgg tgctactgca ggaacagaat 420 gccgtaagtc tgtcccatgt ggatgggaaa gagttgtgaa gcaaaggtta tttgggaaga 480 cagcaggaag atttgatgtg tactttatca gcccacaagg actgaagttc agatccaaaa 540 gttcacttgc taattatctt cacaaaaatg gagagacttc tcttaagcca gaagattttg 600 attttactgt actttctaaa aggggtatca agtcaagata taaagactgc agcatggcag 660 ccctgacatc ccatctacaa aaccaaagta acaattcaaa ctggaacctc aggacccgaa 720 gcaagtgcaa aaaggatgtg tttatgccgc caagtagtag ttcagagttg caggagagca 780 gaggactctc taactttact tccactcatt tgcttttgaa agaagatgag ggtgttgatg 840 atgttaactt cagaaaggtt agaaagccca aaggaaaggt gactattttg aaaggaatcc 900 caattaagaa aactaaaaaa ggatgtagga agagctgttc aggttttgtt caaagtgata 960 gcaaaagaga atctgtgtgt aataaagcag atgctgaaag tgaacctgtt gcacaaaaaa 1020 gtcagcttga tagaactgtc tgcatttctg atgctggagc atgtggtgag accctcagtg 1080 tgaccagtga agaaaacagc cttgtaaaaa aaaaagaaag atcattgagt tcaggatcaa 1140 atttttgttc tgaacaaaaa acttctggca tcataaacaa attttgttca gccaaagact 1200 cagaacacaa cgagaagtat gaggatacct ttttagaatc tgaagaaatc ggaacaaaag 1260 tagaagttgt ggaaaggaaa gaacatttgc atactgacat tttaaaacgt ggctctgaaa 1320 tggacaacaa ctgctcacca accaggaaag acttcactgg tgagaaaata tttcaagaag 1380 ataccatccc acgaacacag atagaaagaa ggaaaacaag cctgtatttt tccagcaaat 1440 ataacaaaga agctcttagc cccccacgac gtaaagcctt taagaaatgg acacctcctc 1500 ggtcaccttt taatctcgtt caagaaacac tttttcatga tccatggaag cttctcatcg 1560 ctactatatt tctcaatcgg acctcaggca aaatggcaat acctgtgctt tggaagtttc 1620 tggagaagta tccttcagct gaggtagcaa gaaccgcaga ctggagagat gtgtcagaac 1680 ttcttaaacc tcttggtctc tacgatcttc gggcaaaaac cattgtcaag ttctcagatg 1740 aatacctgac aaagcagtgg aagtatccaa ttgagcttca tgggattggt aaatatggca 1800 acgactctta ccgaattttt tgtgtcaatg agtggaagca ggtgcaccct gaagaccaca 1860 aattaaataa atatcatgac tggctttggg aaaatcatga aaaattaagt ctatcttaaa 1920 ctctgcagct ttcaagctca tctgttatgc atagctttgc acttcaaaaa agcttaatta 1980 agtacaacca accacctttc cagccataga gattttaatt agcccaacta gaagcctagt 2040 gtgtgtgctt tcttaatgtg tgtgccaatg gtggatcttt gctactgaat gtgtttgaac 2100 atgttttgag atttttttaa aataaattat tatttgacaa caatccaaaa aaaatacggc 2160 ttttccaatg atgaaatata atcagaagat gaaaaatagt tttaaactat caataataca 2220 aagcaaattt ctatcagcct tgctaaagct aggggcccac taaatatttt tatcggctag 2280 gcgtggtggt gcatgcctgt aatctcggaa ggctgaggca ggaggatcat ttgagctcat 2340 gagggcccag gaggtcaagg cttcagtgag ccatgatcat gccactgcac tccagtctgg 2400 atgacagaga gagaccctgt ctcaaaaaat atatatttaa aaaataaaaa taaaagctga 2460 ccccaaagac 2470 <210> 422 <211> 2470 <212> DNA <213> Homo sapiens <400> 422 ggcggctgta gccgaggggg cggccggaaa gcagcggcgg cgtctggggc gctttcgcaa 60 cattcagacc tcggttgcag cccggtgccg tgagctgaag aggtttcaca tcttactccg 120 ccccacaccc tgggcgttgc ggcgctgggc tcgttgctgc agccggaccc tgctcgatgg 180 gcacgactgg gctggagagt ctgagtctgg gggaccgcgg agctgccccc accgtcacct 240 ctagtgagcg cctagtccca gacccgccga atgacctccg caaagaagat gttgctatgg 300 aattggaaag agtgggagaa gatgaggaac aaatgatgat aaaaagaagc agtgaatgta 360 atcccttgct acaagaaccc atcgcttctg ctcagtttgg tgctactgca ggaacagaat 420 gccgtaagtc tgtcccatgt ggatgggaaa gagttgtgaa gcaaaggtta tttgggaaga 480 cagcaggaag atttgatgtg tactttatca gcccacaagg actgaagttc agatccaaaa 540 gttcacttgc taattatctt cacaaaaatg gagagacttc tcttaagcca gaagattttg 600 attttactgt actttctaaa aggggtatca agtcaagata taaagactgc agcatggcag 660 ccctgacatc ccatctacaa aaccaaagta acaattcaaa ctggaacctc aggacccgaa 720 gcaagtgcaa aaaggatgtg tttatgccgc caagtagtag ttcagagttg caggagagca 780 gaggactctc taactttact tccactcatt tgcttttgaa agaagatgag ggtgttgatg 840 atgttaactt cagaaaggtt agaaagccca aaggaaaggt gactattttg aaaggaatcc 900 caattaagaa aactaaaaaa ggatgtagga agagctgttc aggttttgtt caaagtgata 960 gcaaaagaga atctgtgtgt aataaagcag atgctgaaag tgaacctgtt gcacaaaaaa 1020 gtcagcttga tagaactgtc tgcatttctg atgctggagc atgtggtgag accctcagtg 1080 tgaccagtga agaaaacagc cttgtaaaaa aaaaagaaag atcattgagt tcaggatcaa 1140 atttttgttc tgaacaaaaa acttctggca tcataaacaa attttgttca gccaaagact 1200 cagaacacaa cgagaagtat gaggatacct ttttagaatc tgaagaaatc ggaacaaaag 1260 tagaagttgt ggaaaggaaa gaacatttgc atactgacat tttaaaacgt ggctctgaaa 1320 tggacaacaa ctgctcacca accaggaaag acttcactgg tgagaaaata tttcaagaag 1380 ataccatccc acgaacacag atagaaagaa ggaaaacaag cctgtatttt tccagcaaat 1440 ataacaaaga agctcttagc cccccacgac gtaaagcctt taagaaatgg acacctcctc 1500 ggtcaccttt taatctcgtt caagaaacac tttttcatga tccatggaag cttctcatcg 1560 ctactatatt tctcaatcgg acctcaggca aaatggcaat acctgtgctt tggaagtttc 1620 tggagaagta tccttcagct gaggtagcaa gaaccgcaga ctggagagat gtgtcagaac 1680 ttcttaaacc tcttggtctc tacgatcttc gggcaaaaac cattgtcaag ttctcagatg 1740 aatacctgac aaagcagtgg aagtatccaa ttgagcttca tgggattggt aaatatggca 1800 acgactctta ccgaattttt tgtgtcaatg agtggaagca ggtgcaccct gaagaccaca 1860 aattaaataa atatcatgac tggctttggg aaaatcatga aaaattaagt ctatcttaaa 1920 ctctgcagct ttcaagctca tctgttatgc atagctttgc acttcaaaaa agcttaatta 1980 agtacaacca accacctttc cagccataga gattttaatt agcccaacta gaagcctagt 2040 gtgtgtgctt tcttaatgtg tgtgccaatg gtggatcttt gctactgaat gtgtttgaac 2100 atgttttgag atttttttaa aataaattat tatttgacaa caatccaaaa aaaatacggc 2160 ttttccaatg atgaaatata atcagaagat gaaaaatagt tttaaactat caataataca 2220 aagcaaattt ctatcagcct tgctaaagct aggggcccac taaatatttt tatcggctag 2280 gcgtggtggt gcatgcctgt aatctcggaa ggctgaggca ggaggatcat ttgagctcat 2340 gagggcccag gaggtcaagg cttcagtgag ccatgatcat gccactgcac tccagtctgg 2400 atgacagaga gagaccctgt ctcaaaaaat atatatttaa aaaataaaaa taaaagctga 2460 ccccaaagac 2470 <210> 423 <211> 2152 <212> DNA <213> Homo sapiens <400> 423 ggcggcgtct ggggcgcttt cgcaacattc agacctcggt tgcagcccgg tgccgtgagc 60 tgaagaggtt tcacatctta ctccgcccca caccctgggc gttgcggcgc tgggctcgtt 120 gctgcagccg gaccctgctc gatgggcacg actgggctgg agagtctgag tctgggggac 180 cgcggagctg cccccaccgt cacctctagt gagcgcctag tcccagaccc gccgaatgac 240 ctccgcaaag aagatgttgc tatggaattg gaaagagtgg gagaagatga ggaacaaatg 300 atgataaaaa gaagcagtga atgtaatccc ttgctacaag aacccatcgc ttctgctcag 360 tttggtgcta ctgcaggaac agaatgccgt aagtctgtcc catgtggatg ggaaagagtt 420 gtgaagcaaa ggttatttgg gaagacagca ggaagatttg atgtgtactt tatcagccca 480 caaggactga agttcagatc caaaagttca cttgctaatt atcttcacaa aaatggagag 540 acttctctta agccagaaga ttttgatttt actgtacttt ctaaaagggg tatcaagtca 600 agatataaag actgcagcat ggcagccctg acatcccatc tacaaaacca aagtaacaat 660 tcaaactgga acctcaggac ccgaagcaag tgcaaaaagg atgtgtttat gccgccaagt 720 agtagttcag agttgcagga gagcagagga ctctctaact ttacttccac tcatttgctt 780 ttgaaagaag atgagggtgt tgatgatgtt aacttcagaa aggttagaaa gcccaaagga 840 aaggtgacta ttttgaaagg aatcccaatt aagaaaacta aaaaaggatg taggaagagc 900 tgttcaggtt ttgttcaaag tgatagcaaa agagaatctg tgtgtaataa agcagatgct 960 gaaagtgaac ctgttgcaca aaaaagtcag cttgatagaa ctgtctgcat ttctgatgct 1020 ggagcatgtg gtgagaccct cagtgtgacc agtgaagaaa acagccttgt aaaaaaaaaa 1080 gaaagatcat tgagttcagg atcaaatttt tgttctgaac aaaaaacttc tggcatcata 1140 aacaaatttt gttcagccaa agactcagaa cacaacgaga agtatgagga taccttttta 1200 gaatctgaag aaatcggaac aaaagtagaa gttgtggaaa ggaaagaaca tttgcatact 1260 gacattttaa aacgtggctc tgaaatggac aacaactgct caccaaccag gaaagacttc 1320 actggtgaga aaatatttca agaagatacc atcccacgaa cacagataga aagaaggaaa 1380 acaagcctgt atttttccag caaatataac aaagaagctc ttagcccccc acgacgtaaa 1440 gcctttaaga aatggacacc tcctcggtca ccttttaatc tcgttcaaga aacacttttt 1500 catgatccat ggaagcttct catcgctact atatttctca atcggacctc aggcaaaatg 1560 gcaatacctg tgctttggaa gtttctggag aagtatcctt cagctgaggt agcaagaacc 1620 gcagactgga gagatgtgtc agaacttctt aaacctcttg gtctctacga tcttcgggca 1680 aaaaccattg tcaagttctc agatgaatac ctgacaaagc agtggaagta tccaattgag 1740 cttcatggga ttggtaaata tggcaacgac tcttaccgaa ttttttgtgt caatgagtgg 1800 aagcaggtgc accctgaaga ccacaaatta aataaatatc atgactggct ttgggaaaat 1860 catgaaaaat taagtttatc ttaaactctg cagctttcaa gctcatctgt tatgcatagc 1920 tttgcacttc aaaaaagctt aattaagtac aaccaaccac ctttccagcc atagagattt 1980 taattagccc aactagaagc ctagtgtgtg tgctttctta atgtgtgtgc caatggtgga 2040 tctttgctac tgaatgtgtt tgaacatgtt ttgagatttt tttaaaataa attattattt 2100 gacaacaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa 2152 <210> 424 <211> 2105 <212> DNA <213> Homo sapiens <400> 424 cggctgtagc cgagggggcg gccggaaagc agcggcggcg tctggggcgc tttcgcaaca 60 ttcagacctc ggttgcagcc cggtgccgtg agctgaagag gtttcacatc ttactccgcc 120 ccacaccctg ggcgttgcgg cgctgggctc gttgctgcag ccggaccctg ctcgatgggc 180 acgactgggc tggagagtct gagtctgggg gaccgcggag ctgcccccac cgtcacctct 240 agtgagcgcc tagtcccaga cccgccgaat gacctccgca aagaagatgt tgctatggaa 300 ttggaaagag tgggagaaga tgaggaacaa atgatgataa aaagaagcag tgaatgtaat 360 cccttgctac aagaacccat cgcttctgct cagtttggtg ctactgcagg aacagaatgc 420 cgtaagtctg tcccatgtgg atgggaaaga gttgtgaagc aaaggttatt tgggaagaca 480 gcaggaagat ttgatgtgta ctttatcagc ccacaaggac tgaagttcag atccaaaagt 540 tcacttgcta attatcttca caaaaatgga gagacttctc ttaagccaga agattttgat 600 tttactgtac tttctaaaag gggtatcaag tcaagatata aagactgcag catggcagcc 660 ctgacatccc atctacaaaa ccaaagtaac aattcaaact ggaacctcag gacccgaagc 720 aagtgcaaaa aggatgtgtt tatgccgcca agtagtagtt cagagttgca ggagagcaga 780 ggactctcta actttacttc cactcatttg cttttgaaag aagatgaggg tgttgatgat 840 gttaacttca gaaaggttag aaagcccaaa ggaaaggtga ctattttgaa aggaatccca 900 attaagaaaa ctaaaaaagg atgtaggaag agctgttcag gttttgttca aagtgatagc 960 aaaagagaat ctgtgtgtaa taaagcagat gctgaaagtg aacctgttgc acaaaaaagt 1020 cagcttgata gaactgtctg catttctgat gctggagcat gtggtgagac cctcagtgtg 1080 accagtgaag aaaacagcct tgtaaaaaaa aaagaaagat cattgagttc aggatcaaat 1140 ttttgttctg aacaaaaaac ttctggcatc ataaacaaat tttgttcagc caaagactca 1200 gaacacaacg agaagtatga ggataccttt ttagaatctg aagaaatcgg aacaaaagta 1260 gaagttgtgg aaaggaaaga acatttgcat actgacattt taaaacgtgg ctctgaaatg 1320 gacaacaact gctcaccaac caggaaagac ttcactggtg agaaaatatt tcaagaagat 1380 accatcccac gaacacagat agaaagaagg aaaacaagcc tgtatttttc cagcaaatat 1440 aacaaagaag ctcttagccc cccacgacgt aaagccttta agaaatggac acctcctcgg 1500 tcacctttta atctcgttca agaaacactt tttcatgatc catggaagct tctcatcgct 1560 actatatttc tcaatcggac ctcaggcaaa atggcaatac ctgtgctttg gaagtttctg 1620 gagaagtatc cttcagctga ggtagcaaga accgcagact ggagagatgt gtcagaactt 1680 cttaaacctc ttggtctcta cgatcttcgg gcaaaaacca ttgtcaagtt ctcagatgaa 1740 tacctgacaa agcagtggaa gtatccaatt gagcttcatg ggattggtgc accctgaaga 1800 ccacaaatta aataaatatc atgactggct ttgggaaaat catgaaaaat taagtctatc 1860 ttaaactctg cagctttcaa gctcatctgt tatgcatagc tttgcacttc aaaaaagctt 1920 aattaagtac aaccaaccac ctttccagcc atagagattt taattagccc aactagaagc 1980 ctacgtgtgt gtgctttctt aatgtgtgtg ccaatggtgg atctttgcta ctgaatgtgt 2040 ttgaacatgt tttgagattt ttttaaaata aattattatt tgacaacaat ccaaaaaaaa 2100 aaaaa 2105 <210> 425 <211> 2002 <212> DNA <213> Homo sapiens <400> 425 gcagccggac cctgctcgat gggcacgact gggctggaga gtctgagtct gggggaccgc 60 ggagctgccc ccaccgtcac ctctagtgag cgcctagtcc cagacccgcc gaatgacctc 120 cgcaaagaag atgttgctat ggaattggaa agagtgggag aagatgagga acaaatgatg 180 ataaaaagaa gcagtgaatg taatcccttg ctacaagaac ccatcgcttc tgctcagttt 240 ggtgctactg caggaacaga atgccgtaag tctgtcccat gtggatggga aagagttgtg 300 aagcaaaggt tatttgggaa gacagcagga agatttgatg tgtactttat cagcccacaa 360 ggactgaagt tcagatccaa aagttcactt gctaattatc ttcacaaaaa tggagagact 420 tctcttaagc cagaagattt tgattttact gtactttcta aaaggggtat caagtcaaga 480 tataaagact gcagcatggc agccctgaca tcccatctac aaaaccaaag taacaattca 540 aactggaacc tcaggacccg aagcaagtgc aaaaaggatg tgtttatgcc gccaagtagt 600 agttcagagt tgcaggagag cagaggactc tctaacttta cttccactca tttgcttttg 660 aaagaagatg agggtgttga tgatgttaac ttcagaaagg ttagaaagcc caaaggaaag 720 gtgactattt tgaaaggaat cccaattaag aaaactaaaa aaggatgtag gaagagctgt 780 tcaggttttg ttcaaagtga tagcaaaaga gaatctgtgt gtaataaagc agatgctgaa 840 agtgaacctg ttgcacaaaa aagtcagctt gatagaactg tctgcatttc tgatgctgga 900 gcatgtggtg agaccctcag tgtgaccagt gaagaaaaca gccttgtaaa aaaaaaagaa 960 agatcattga gttcaggatc aaatttttgt tctgaacaaa aaacttctgg catcataaac 1020 aaattttgtt cagccaaaga ctcagaacac aacgagaagt atgaggatac ctttttagaa 1080 tctgaagaaa tcggaacaaa agtagaagtt gtggaaagga aagaacattt gcatactgac 1140 attttaaaac gtggctctga aatggacaac aactgctcac caaccaggaa agacttcact 1200 gaagatacca tcccacgaac acagatagaa agaaggaaaa caagcctgta tttttccagc 1260 aaatataaca aagaagctct tagcccccca cgacgtaaag cctttaagaa atggacacct 1320 cctcggtcac cttttaatct cgttcaagaa acactttttc atgatccatg gaagcttctc 1380 atcgctacta tatttctcaa tcggacctca ggcaaaatgg caatacctgt gctttggaag 1440 tttctggaga agtatccttc agctgaggta gcaagaaccg cagactggag agatgtgtca 1500 gaacttctta aacctcttgg tctctacgat cttcgggcaa aaaccattgt caagttctca 1560 gatgaatacc tgacaaagca gtggaagtat ccaattgagc ttcatgggat tggtaaatat 1620 ggcaacgact cttaccgaat tttttgtgtc aatgagtgga agcaggtgca ccctgaagac 1680 cacaaattaa ataaatatca tgactggctt tgggaaaatc atgaaaaatt aagtctatct 1740 taaactctgc agctttcaag ctcatctgtt atgcatagct ttgcacttca aaaaagctta 1800 attaagtaca accaaccacc tttccagcca tagagatttt aattagccca actagaagcc 1860 tagtgtgtgt gctttcttaa tgtgtgtgcc aatggtggat ctttgctact gaatgtgttt 1920 gaacatgttt tgagattttt ttaaaataaa ttattatttg acaacaaaaa aaaaaaaaaa 1980 aaaaaaaaaa aaaaaaaaaa aa 2002 <210> 426 <211> 2021 <212> DNA <213> Homo sapiens <400> 426 ggcacgaggg cgttgcggcg ctgggctcgt tgctgcagcc ggaccctgct cgatgggcac 60 gactgggctg gagagtctga gtctggggga ccgcggagct gcccccaccg tcacctctag 120 tgagcgccta gtcccagacc cgccgaatga cctccgcaaa gaagatgttg ctatggaatt 180 ggaaagagtg ggagaagatg aggaacaaat gatgataaaa agaagcagtg aatgtaatcc 240 cttgctacaa gaacccatcg cttctgctca gtttggtgct actgcaggaa cagaatgccg 300 taagtctgtc ccatgtggat gggaaagagt tgtgaagcaa aggttatttg ggaagacagc 360 aggaagattt gatgtgtact ttatcagccc acaaggactg aagttcagat ccaaaagttc 420 acttgctaat tatcttcaca aaaatggaga gacttctctt aagccagaag attttgattt 480 tactgtactt tctaaaaggg gtatcaagtc aagatataaa gactgcagca tggcagccct 540 gacatcccat ctacaaaacc aaagtaacaa ttcaaactgg aacctcagga cccgaagcaa 600 gtgcaaaaag gatgtgttta tgccgccaag tagtagttca gagttgcagg agagcagagg 660 actctctaac tttacttcca ctcatttgct tttgaaagaa gatgagggtg ttgatgatgt 720 taacttcaga aaggttagaa agcccaaagg aaaggtgact attttgaaag gaatcccaat 780 taagaaaact aaaaaaggat gtaggaagag ctgttcaggt tttgttcaaa gtgatagcaa 840 aagagaatct gtgtgtaata aagcagatgc tgaaagtgaa cctgttgcac aaaaaagtca 900 gcttgataga actgtctgca tttctgatgc tggagcatgt ggtgagaccc tcagtgtgac 960 cagtgaagaa aacagccttg taaaaaaaaa agaaagatca ttgagttcag gatcaaattt 1020 ttgttctgaa caaaaaactt ctggcatcat aaacaaattt tgttcagcca aagactcaga 1080 acacaacgag aagtatgagg ataccttttt agaatctgaa gaaatcggaa caaaagtaga 1140 agttgtggaa aggaaagaac atttgcatac tgacatttta aaacgtggct ctgaaatgga 1200 caacaactgc tcaccaacca ggaaagactt cactgaagat accatcccac gaacacagat 1260 agaaagaagg aaaacaagcc tgtatttttc cagcaaatat aacaaagaag ctcttagccc 1320 cccacgacgt aaagccttta agaaatggac acctcctcgg tcacctttta atctcgttca 1380 agaaacactt tttcatgatc catggaagct tctcatcgct actatatttc tcaatcggac 1440 ctcaggcaaa atggcaatac ctgtgctttg gaagtttctg gagaagtatc cttcagctga 1500 ggtagcaaga accgcagact ggagagatgt gtcagaactt cttaaacctc ttggtctcta 1560 cgatcttcgg gcaaaaacca ttgtcaagtt ctcagatgaa tacctgacaa agcagtggaa 1620 gtatccaatt gagcttcatg ggattggtaa atatggcaac gactcttacc gaattttttg 1680 tgtcaatgag tggaagcagg tgcaccctga agaccacaaa ttaaataaat atcatgactg 1740 gctttgggaa aatcatgaaa aattaagtct atcttaaact ctgcagcttt caagctcatc 1800 tgttatgcat agctttgcac ttcaaaaaag cttaattaag tacaaccaac cacctttcca 1860 gccatagaga ttttaattag cccaactaga agcctagtgt gtgtgctttc ttaatgtgtg 1920 tgccaatggt ggatctttgc tactgaatgt gtttgaacat gttttgagat ttttttaaaa 1980 taaattatta tttgacaaca aaaaaaaaaa aaaaaaaaaa a 2021 <210> 427 <211> 459 <212> DNA <213> Homo sapiens <220> <221> misc_feature <222> (248)..(248) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (305)..(305) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (341)..(341) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (346)..(347) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (372)..(372) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (379)..(379) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (389)..(389) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (405)..(406) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (434)..(434) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (447)..(447) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (454)..(454) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (456)..(456) <223> "n" means any of A, T, G, and C. <400> 427 ggcacgaggc gcggcacgag gcgctgggct cgttgctgca gccggaccct gctcgatggg 60 cacgactggg ctggagagtc tgagtctggg ggaccgcgga gctgccccca ccgtcacctc 120 tagtgagcgc ctagtcccag acccgccgaa tgacctccgc aaagaagatg ttgctatgga 180 attggaaaga gtgggagaag atgaggaaca aatgatgata aaaagaagca gtgaatgtaa 240 tcccttgnta caagaaaccc atcgcttctg ctcagtttgg tgctactgca ggaacagaat 300 gccgnaagtc tgtcccatgt ggatgggaaa gagttggtga ngcaannggt tatttgggga 360 agacagcagg angatttgnt gtgtacttna tcagccccac aaggnntgaa gttcagatcc 420 aaaagttcaa ttgntaatta tctccanaaa attngngag 459 <210> 428 <211> 494 <212> DNA <213> Homo sapiens <220> <221> misc_feature <222> (20)..(20) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (68)..(68) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (92)..(92) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (102)..(102) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (108)..(108) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (152)..(152) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (201)..(201) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (253)..(253) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (295)..(295) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (297)..(297) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (299)..(301) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (305)..(305) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (313)..(313) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (317)..(317) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (320)..(320) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (325)..(325) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (338)..(338) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (342)..(342) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (356)..(356) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (359)..(360) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (364)..(364) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (367)..(367) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (371)..(371) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (388)..(388) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (396)..(397) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (401)..(401) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (412)..(412) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (416)..(416) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (418)..(419) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (430)..(430) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (439)..(439) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (442)..(443) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (447)..(448) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (464)..(464) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (466)..(466) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (474)..(475) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (477)..(477) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (479)..(479) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (481)..(481) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (483)..(483) <223> "n" means any of A, T, G, and C. <400> 428 gctgggttcg ttgctgcagn cggaccctgc tcgatgggca cgactgggct ggagagtctg 60 agtctggngg accgcggagc tgcccccacc gncacctcta gngagcgnct agtcccagac 120 ccggcgaatg agctccgcaa agaagatgtt gntatggaat tggaaagagt gggagaagat 180 gaggaacaaa tgatgataaa nagaagcagt gaatgtaatc ccttgctaca agaacccatc 240 gcttctgctc agnttgggtg ctactgcagg agcagaatgc cgtagtcttt cccanancnn 300 ntggnaaaga gtnggtnaan caacncgtta tttgggcnac cnaagaagga aggatnggnn 360 cttnttnctt ncatcaagcc aacaaagnat tgaagnncca ncctcccaaa anccantnng 420 ttatttttcn tccaaacanc tnnggannct tctcttcacc cagncnattc gggnntncnc 480 ntnccttcct taaa 494 <210> 429 <211> 3165 <212> DNA <213> Homo sapiens <400> 429 gggggacagt agaagcctgg aggaggagct tgagtccagc cactgtctgg gtactgccag 60 ccatcgggcc caggtctctg gggttgtctt accgcagtga gtaccacgcg gtactacaga 120 gaccggctgc ccgtgtgccc ggcaggtgga gccgcccgca tcagcggcct cggggaatgg 180 aagcggagaa cgcgggcagc tattcccttc agcaagctca agctttttat acgtttccat 240 ttcaacaact gatggctgaa gctcctaata tggcagttgt gaatgaacag caaatgccag 300 aagaagttcc agccccagct cctgctcagg aaccagtgca agaggctcca aaaggaagaa 360 aaagaaaacc cagaacaaca gaaccaaaac aaccagtgga acccaaaaaa cctgttgagt 420 caaaaaaatc tggcaagtct gcaaaatcaa aagaaaaaca agaaaaaatt acagacacat 480 ttaaagtaaa aagaaaagta gaccgtttta atggtgtttc agaagctgaa cttctgacca 540 agactctccc cgatattttg accttcaatc tggacattgt cattattggc ataaacccgg 600 gactaatggc tgcttacaaa gggcatcatt accctggacc tggaaaccat ttttggaagt 660 gtttgtttat gtcagggctc agtgaggtcc agctgaacca tatggatgat cacactctac 720 cagggaagta tggtattgga tttaccaaca tggtggaaag gaccacgccc ggcagcaaag 780 atctctccag taaagaattt cgtgaaggag gacgtattct agtacagaaa ttacagaaat 840 atcagccacg aatagcagtg tttaatggaa aatgtattta tgaaattttt agtaaagaag 900 tttttggagt aaaggttaag aacttggaat ttgggcttca gccccataag attccagaca 960 cagaaactct ctgctatggt atgccatcat ccagtgcaag atgtgctcag tttcctcgag 1020 cccaagacaa agttcattac tacataaaac tgaaggactt aagagatcag ttgaaaggca 1080 ttgaacgaaa tatggacgtt caagaggtgc aatatacatt tgacctacag cttgcccaag 1140 aggatgcaaa gaagatggct gttaaggaag aaaaatatga tccaggttat gaggcagcat 1200 atggtggtgc ttacggagaa aatccatgca gcagtgaacc ttgtggcttc tcttcaaatg 1260 ggctaattga gagcgtggag ttaagaggag aatcagcttt cagtggcatt cctaatgggc 1320 agtggatgac ccagtcattt acagaccaaa ttccttcctt tagtaatcac tgtggaacac 1380 aagaacagga agaagaaagc catgcttaag aatggtgctt ctcagctctg cttaaatgct 1440 gcagttttaa tgcagttgtc aacaagtaga acctcagttt gctaactgaa gtgttttatt 1500 agtattttac tctagtggtg taattgtaat gtagaacagt tgtgtggtag tgtgaaccgt 1560 atgaacctaa gtagtttgga agaaaaagta gggtttttgt atactagctt ttgtatttga 1620 attaattatc attccagctt tttatatact atatttcatt tatgaagaaa ttgattttct 1680 tttgggagtc acttttaatc tgtaatttta aaatacaagt ctgaatattt atagttgatt 1740 cttaactgtg cataaaccta gatataccat tatccctttt atacctaaga agggcatgct 1800 aataattacc actgtcaaag aggcaaaggt gttgattttt gtatatgaag ttaagcctca 1860 gtggagtctc atttgttagt ttttagtggt aactaagggt aaactcaggg ttccctgagc 1920 tatatgcaca ctcagacctc tttgctttac cagtggtgtt tgtgagttgc tcagtagtaa 1980 aaactggcct tacctgacag agccctggct ttgacctgct cagccctgtg tgttaatcct 2040 ctagtagcca attaactact ctggggtggc aggttccaga gaatgcagta gaccttttgc 2100 cactcatctg tgttttactt gagacatgta aatatgatag ggaaggaact gaatttctcc 2160 attcatattt ataaccattc tagttttatc ttccttggct ttaagagtgt gccatggaaa 2220 gtgataagaa atgaacttct aggctaagca aaaagatgct ggagatattt gatactctca 2280 tttaaactgg tgctttatgt acatgagatg tactaaaata agtaatatag aatttttctt 2340 gctaggtaaa tccagtaagc caataatttt aaagattctt tatctgcatc attgctgttt 2400 gttactataa attaaatgaa cctcatggaa aggttgaggt gtataccttt gtgattttct 2460 aatgagtttt ccatggtgct acaaataatc cagactacca ggtctggtag atattaaagc 2520 tgggtactaa gaaatgttat ttgcatcctc tcagttactc ctgaatattc tgatttcata 2580 cgtacccagg gagcatgctg ttttgtcaat caatataaaa tatttatgag gtctccccca 2640 cccccaggag gttatatgat tgctcttctc tttataataa gagaaacaaa ttcttattgt 2700 gaatcttaac atgcttttta gctgtggcta tgatggattt tattttttcc taggtcaagc 2760 tgtgtaaaag tcatttatgt tatttaaatg atgtactgta ctgctgttta catggacgtt 2820 ttgtgcgggt gctttgaagt gccttgcatc agggattagg agcaattaaa ttattttttc 2880 acgggactgt gtaaagcatg taactaggta ttgctttggt atataactat tgtagcttta 2940 caagagattg ttttatttga atggggaaaa taccctttaa attatgacgg acatccacta 3000 gagatgggtt tgaggatttt ccaagcgtgt aataatgatg tttttcctaa catgacagat 3060 gagtagtaaa tgttgatata tcctataaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 3120 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa 3165 <210> 430 <211> 3165 <212> DNA <213> Homo sapiens <400> 430 gggggacagt agaagcctgg aggaggagct tgagtccagc cactgtctgg gtactgccag 60 ccatcgggcc caggtctctg gggttgtctt accgcagtga gtaccacgcg gtactacaga 120 gaccggctgc ccgtgtgccc ggcaggtgga gccgcccgca tcagcggcct cggggaatgg 180 aagcggagaa cgcgggcagc tattcccttc agcaagctca agctttttat acgtttccat 240 ttcaacaact gatggctgaa gctcctaata tggcagttgt gaatgaacag caaatgccag 300 aagaagttcc agccccagct cctgctcagg aaccagtgca agaggctcca aaaggaagaa 360 aaagaaaacc cagaacaaca gaaccaaaac aaccagtgga acccaaaaaa cctgttgagt 420 caaaaaaatc tggcaagtct gcaaaatcaa aagaaaaaca agaaaaaatt acagacacat 480 ttaaagtaaa aagaaaagta gaccgtttta atggtgtttc agaagctgaa cttctgacca 540 agactctccc cgatattttg accttcaatc tggacattgt cattattggc ataaacccgg 600 gactaatggc tgcttacaaa gggcatcatt accctggacc tggaaaccat ttttggaagt 660 gtttgtttat gtcagggctc agtgaggtcc agctgaacca tatggatgat cacactctac 720 cagggaagta tggtattgga tttaccaaca tggtggaaag gaccacgccc ggcagcaaag 780 atctctccag taaagaattt cgtgaaggag gacgtattct agtacagaaa ttacagaaat 840 atcagccacg aatagcagtg tttaatggaa aatgtattta tgaaattttt agtaaagaag 900 tttttggagt aaaggttaag aacttggaat ttgggcttca gccccataag attccagaca 960 cagaaactct ctgctatggt atgccatcat ccagtgcaag atgtgctcag tttcctcgag 1020 cccaagacaa agttcattac tacataaaac tgaaggactt aagagatcag ttgaaaggca 1080 ttgaacgaaa tatggacgtt caagaggtgc aatatacatt tgacctacag cttgcccaag 1140 aggatgcaaa gaagatggct gttaaggaag aaaaatatga tccaggttat gaggcagcat 1200 atggtggtgc ttacggagaa aatccatgca gcagtgaacc ttgtggcttc tcttcaaatg 1260 ggctaattga gagcgtggag ttaagaggag aatcagcttt cagtggcatt cctaatgggc 1320 agtggatgac ccagtcattt acagaccaaa ttccttcctt tagtaatcac tgtggaacac 1380 aagaacagga agaagaaagc catgcttaag aatggtgctt ctcagctctg cttaaatgct 1440 gcagttttaa tgcagttgtc aacaagtaga acctcagttt gctaactgaa gtgttttatt 1500 agtattttac tctagtggtg taattgtaat gtagaacagt tgtgtggtag tgtgaaccgt 1560 atgaacctaa gtagtttgga agaaaaagta gggtttttgt atactagctt ttgtatttga 1620 attaattatc attccagctt tttatatact atatttcatt tatgaagaaa ttgattttct 1680 tttgggagtc acttttaatc tgtaatttta aaatacaagt ctgaatattt atagttgatt 1740 cttaactgtg cataaaccta gatataccat tatccctttt atacctaaga agggcatgct 1800 aataattacc actgtcaaag aggcaaaggt gttgattttt gtatatgaag ttaagcctca 1860 gtggagtctc atttgttagt ttttagtggt aactaagggt aaactcaggg ttccctgagc 1920 tatatgcaca ctcagacctc tttgctttac cagtggtgtt tgtgagttgc tcagtagtaa 1980 aaactggcct tacctgacag agccctggct ttgacctgct cagccctgtg tgttaatcct 2040 ctagtagcca attaactact ctggggtggc aggttccaga gaatgcagta gaccttttgc 2100 cactcatctg tgttttactt gagacatgta aatatgatag ggaaggaact gaatttctcc 2160 attcatattt ataaccattc tagttttatc ttccttggct ttaagagtgt gccatggaaa 2220 gtgataagaa atgaacttct aggctaagca aaaagatgct ggagatattt gatactctca 2280 tttaaactgg tgctttatgt acatgagatg tactaaaata agtaatatag aatttttctt 2340 gctaggtaaa tccagtaagc caataatttt aaagattctt tatctgcatc attgctgttt 2400 gttactataa attaaatgaa cctcatggaa aggttgaggt gtataccttt gtgattttct 2460 aatgagtttt ccatggtgct acaaataatc cagactacca ggtctggtag atattaaagc 2520 tgggtactaa gaaatgttat ttgcatcctc tcagttactc ctgaatattc tgatttcata 2580 cgtacccagg gagcatgctg ttttgtcaat caatataaaa tatttatgag gtctccccca 2640 cccccaggag gttatatgat tgctcttctc tttataataa gagaaacaaa ttcttattgt 2700 gaatcttaac atgcttttta gctgtggcta tgatggattt tattttttcc taggtcaagc 2760 tgtgtaaaag tcatttatgt tatttaaatg atgtactgta ctgctgttta catggacgtt 2820 ttgtgcgggt gctttgaagt gccttgcatc agggattagg agcaattaaa ttattttttc 2880 acgggactgt gtaaagcatg taactaggta ttgctttggt atataactat tgtagcttta 2940 caagagattg ttttatttga atggggaaaa taccctttaa attatgacgg acatccacta 3000 gagatgggtt tgaggatttt ccaagcgtgt aataatgatg tttttcctaa catgacagat 3060 gagtagtaaa tgttgatata tcctataaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 3120 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa 3165 <210> 431 <211> 3410 <212> DNA <213> Homo sapiens <400> 431 gcaccaggcg cccagtggag ccgtttggga gaattgcctg cgccacgcag cggggccgga 60 caggcggtaa ggatctgatt aggctttcga acttgagttt gactgatgtc ttctgtgtgg 120 tgtccgctaa atcccacagc atataggatc agtcgcattg gttataaggt ttgcttctgg 180 ctgggtgcgg tggctcatgc ctgtaatcca acattgggag gccaaggcag gcggaccacc 240 tgaagtcggg agcttgagtc cagccactgt ctgggtactg ccagccatcg ggcccaggtc 300 tctggggttg tcttaccgca gtgagtacca cgcggtacta cagagaccgg ctgcccgtgt 360 gcccggcagg tggagccgcc gcatcagcgg cctcggggaa tggaagcgga gaacgcgggc 420 agctattccc ttcagcaagc tcaagctttt tatacgtttc catttcaaca actgatggct 480 gaagctccta atatggcagt tgtgaatgaa cagcaaatgc cagaagaagt tccagcccca 540 gctcctgctc aggaaccagt gcaagaggct ccaaaaggaa gaaaaagaaa acccagaaca 600 acagaaccaa aacaaccagt ggaacccaaa aaacctgttg agtcaaaaaa atctggcaag 660 tctgcaaaac caaaagaaaa acaagaaaaa attacagaca catttaaagt aaaaagaaaa 720 gtagaccgtt ttaatggtgt ttcagaagct gaacttctga ccaagactct ccccgatatt 780 ttgaccttca atctggacat tgtcattatt ggcataaacc cgggactaat ggctgcttac 840 aaagggcatc attaccctgg acctggaaac catttttgga agtgtttgtt tatgtcaggg 900 ctcagtgagg tccagctgaa ccatatggat gatcacactc taccagggaa gtatggtatt 960 ggatttacca acatggtgga aaggaccacg cccggcagca aagatctctc cagtaaagaa 1020 tttcgtgaag gaggacgtat tctagtacag aaattacaga aatatcagcc acgaatagca 1080 gtgtttaatg gaaaatgtat ttatgaaatt tttagtaaag aagtttttgg agtaaaggtt 1140 aagaacttgg aatttgggct tcagccccat aagattccag acacagaaac tctctgctat 1200 gttatgccat catccagtgc aagatgtgct cagtttcctc gagcccaaga caaagttcat 1260 tactacataa aactgaagga cttaagagat cagttgaaag gcattgaacg aaatatggac 1320 gttcaagagg tgcaatatac atttgaccta cagcttgccc aagaggatgc aaagaagatg 1380 gctgttaagg aagaaaaata tgatccaggt tatgaggcag catatggtgg tgcttacgga 1440 gaaaatccat gcagcagtga accttgtggc ttctcttcaa atgggctaat tgagagcgtg 1500 gagttaagag gagaatcagc tttcagtggc attcctaatg ggcagtggat gacccagtca 1560 tttacagacc aaattccttc ctttagtaat cactgtggaa cacaagaaca ggaagaagaa 1620 agccatgctt aagaatggtg cttctcagct ctgcttaaat gctgcagttt taatgcagtt 1680 gtcaacaagt agaacctcag tttgctaact gaagtgtttt attagtattt tactctagtg 1740 gtgtaattgt aatgtagaac agttgtgtgg tagtgtgaac cgtatgaacc taagtagttt 1800 ggaagaaaaa gtagggtttt tgtatactag cttttgtatt tgaattaatt atcattccag 1860 ctttttatat actatatttc atttatgaag aaattgattt tcttttggga gtcactttta 1920 atctgtaatt ttaaaataca agtctgaata tttatagttg attcttaact gtgcataaac 1980 ctagatatac cattatccct tttataccta agaagggcat gctaataatt accactgtca 2040 aagaggcaaa ggtgttgatt tttgtatata agttaagcct cagtggagtc tcatttgtta 2100 gtttttagtg gtaactaagg gtaaactcag ggttccctga gctatatgca cactcagacc 2160 tctttgcttt accagtggtg tttgtgagtt gctcagtagt aaaaactggc ccttacctga 2220 cagagccctg gctttgacct gctcagccct gtgtgttaat cctctagtag ccaattaact 2280 actctggggt ggcaggttcc agagaatcga gtagaccttt tgccactcat ctgtgtttta 2340 cttgagacat gtaaatatga tagggaagga actgaatttc tccattcata tttataacca 2400 ttctagtttt atcttccttg gctttaagag tgtgccatgg aaagtgataa gaaatgaact 2460 tctaggctaa gcaaaaagat gctggagata tttgatactc tcatttaaac tggtgcttta 2520 tgtacatgag atgtactaaa ataagtaata tagaattttt cttgctaggt aaatccagta 2580 agccaataat tttaaagatt ctttatctgc atcattgctg tttgttacta taaattaaat 2640 gaacctcatg gaaaggttga ggtgtatacc tttgtgattt tctaatgagt tttccatggt 2700 gctacaaata atccagacta ccaggtctgg tagatattaa agctgggtac taagaaatgt 2760 tatttgcatc ctctcagtta ctcctgaata ttctgatttc atacgtaccc agggagcatg 2820 ctgttttgtc aatcaatata aaatatttat gaggtctccc ccacccccag gaggttatat 2880 gattgctctt ctctttataa taagagaaac aaattcttat tgtgaatctt aacatgcttt 2940 ttagctgtgg ctatgatgga ttttattttt tcctaggtca agctgtgtaa aagtcattta 3000 tgttatttaa atgatgtact gtactgctgt ttacatggac gttttgtgcg ggtgctttga 3060 agtgccttgc atcagggatt aggagcaatt aaattatttt ttcacgggac tgtgtaaagc 3120 atgtaactag gtattgcttt ggtatataac tattgtagct ttacaagaga ttgttttatt 3180 tgaatgggga aaataccctt taaattatga cggacatcca ctagagatgg gtttgaggat 3240 tttccaagcg tgtaataatg atgtttttcc taacatgaca gatgagtagt aaatgttgat 3300 atatcctata catgacagtg tgagactttt tcattaaata atattgaaag attttaaaat 3360 tcatttgaaa gtctgatggc ttttacaata aaagatatta agaattgtta 3410 <210> 432 <211> 1400 <212> DNA <213> Homo sapiens <400> 432 gtgggggaca gtagaagcct ggaggaggag cttgagtcca gccactgtct gggtactgcc 60 agccatcggg cccaggtctc tggggttgtc ttaccgcagt gagtaccacg cggtactaca 120 gagaccggct gcccgtgtgc ccggcaggtg gagccgcccg catcagcggc ctcggggaat 180 ggaagcggag aacgcgggca gctattccct tcagcaagct caagcttttt atacgttcca 240 tttcaacaac tgatggctga agctcctaat atggcagttg tgaatgaaca gcaaatgcca 300 gaagaagttc cagccccagc tcctgctcag gaaccagtgc aagaggctcc aaaaggaaga 360 aaaagaaaac ccagaacaac agaaccaaaa caaccagtgg aacccaaaaa acctgttgag 420 tcaaaaaaat ctggcaagtc tgcaaaatca aaagaaaaac aagaaaaaat tacagacaca 480 tttaaagtaa aaagaaaagt agaccgtttt aatggtgttt cagaagctga acttctgacc 540 aagactctcc ccgatatttt gaccttcaat ctggacattg tcattattgg cataaacccg 600 ggactaatgg ctgcttacaa agggcatcat taccctggac ctggaaacca tttttggaag 660 tgtttgttta tgtcagggct cagtgaggtc cagctgaacc atatggatga tcacactcta 720 ccagggaagt atggtattgg atttaccaac atggtggaaa ggaccacgcc cggcagcaaa 780 gatctctcca gtaaagaatt tcgtgaagga ggacgtattc tagtacagaa attacagaaa 840 tatcagccac gaatagcagt gtttaatgga aaatgtattt atgaaatttt tagtaaagaa 900 gtttttggag taaaggttaa gaacttggaa tttgggcttc agccccataa gattccagac 960 acagaaactc tctgctatgt tatgccatca tccagtgcaa gatgtgctca gtttcctcga 1020 gcccaagaca aagttcatta ctacataaaa ctgaaggact taagagatca gttgaaaggc 1080 attgaacgaa atatggacgt tcaagaggtg caatatacat ttgacctaca gcttgcccaa 1140 gaggatgcaa agaagatggc tgttaaggaa gaaaaatatg atccaggtta tgaggcagca 1200 tatggtggtg cttacggaga aaatccatgc agcagtgaac cttgtggctt ctcttcaaat 1260 gggctaattg agagcgtgga gttaagagga gaatcagctt tcagtggcat tcctaatggg 1320 cagtggatga cccagtcatt tacagaccaa attccttcct ttagtaatca ctgtggaaca 1380 caagaaaaaa aaaaaaaaaa 1400 <210> 433 <211> 483 <212> DNA <213> Homo sapiens <400> 433 ggggggggcc gtgggggaca gtagaagcct ggaggaggag cttgagtcca gccactgtct 60 gggtactgcc agccatcggg cccaggtctc tggggttgtc ttaccgcagt gagtaccacg 120 cggtactaca gagaccggct gcccgtgtgc ccggcaggtg gagccgcccg catcagcggc 180 ctcggggaat ggaagcggag aacgcgggca gctattccct tcagcaagct caagcttttt 240 atacgtttcc atttcaacaa ctgatggctg aagctcctaa tatggcagtt gtgaatgaac 300 agcaaatgcc agaagaagtt ccagccccag ctcctgctca ggaaccagtg caagaggctc 360 caaaaggaag aaaaagaaaa cccagaacaa cagaaccaaa acaaccagtg gaacccaaaa 420 aacctgttga gtcaaaaaaa tctggcaagt ctacaaaaaa aaaaaaaaaa aaaaaaaaaa 480 aaa 483 <210> 434 <211> 1097 <212> DNA <213> Homo sapiens <400> 434 ggccgcatgg gccgccggga tgtgtagtcc gcaggagtcc ggcatgaccg ccttgagcgc 60 gaggatgctg acccggagcc ggagcctggg acccggggct gggccgcggg ggtgtaggga 120 ggagcccggg cctctccgga gaagagaggc tgcagcagaa gcgaggaaaa gccacagccc 180 cgtgaagcgt ccgcggaaag cacagagact gcgtgtggcc tatgagggct cggacagtga 240 gaaaggtgag ggggctgagc ccctcaaggt gccagtctgg gagccccagg actggcagca 300 acagctggtc aacatccgtg ccatgaggaa caaaaaggat gcacctgtgg accatctggg 360 gactgagcac tgctatgact ccagtgcccc cccaaaggta cgcaggtacc aggtgctgct 420 gtcactgatg ctctccagcc aaaccaaaga ccaggtgacg gcgggcgcca tgcagcgact 480 gcgggcgcgg ggcctgacgg tggacagcat cctgcagaca gatgatgcca cgctgggcaa 540 gctcatctac cccgtcggtt tctggaggag caaggtgaaa tacatcaagc agaccagcgc 600 catcctgcag cagcactacg gtggggacat cccagcctct gtggccgagc tggtggcgct 660 gccgggtgtt gggcccaaga tggcacacct ggctatggct gtggcctggg gcactgtgtc 720 aggcattgca gtggacacgc atgtgcacag aatcgccaac aggctgaggt ggaccaagaa 780 ggcaaccaag tccccagagg agacccgcgc cgccctggag gagtggctgc ctagggagct 840 gtggcacgag atcaatggac tcttggtggg cttcggccag cagacctgtc tgcctgtgca 900 ccctcgctgc cacgcctgcc tcaaccaagc cctctgcccg gccgcccagg gtctctgatg 960 gccgcatggc tctggccgag gtgccgctgt ggccaccgtc tgtgaagtgg ctttacgctt 1020 caggaagcca cgcctgttga ataaagcttt ggtgtgtttg cagatggaaa aaaaaaaaaa 1080 aaaaaaaaaa aaaaaaa 1097 <210> 435 <211> 1061 <212> DNA <213> Homo sapiens <400> 435 ggccgcatgg gccgccggga tgtgtagtcc gcaggagtcc ggcatgaccg ccttgagcgc 60 gaggatgctg acccggagcc ggagcctggg acccggggct ggaccgcggg ggtgtaggga 120 ggagcccggg cctctccgga gaagagaggc tgcagcagaa gcgaggaaaa gccacagccc 180 cgtgaagcgt ccgcggaaag cacagagact gcgtgtggcc tatgagggct cggacagtga 240 gaaaggtgag ggggctgagc ccctcaaggt gccagtctgg gagccccagg actggcagca 300 acagctggtc aacatccgtg ccatgaggaa caaaaaggat gcacctgtgg accatctggg 360 gactgagcac tgctatgact ccagtgcccc cccaaaggta cgcaggtacc aggtgctgct 420 gtcactgatg ctctccagcc aaaccaaaga ccaggtgacg gcgggcgcca tacagcgact 480 gcgggcgcgg ggcctggcgg tggacagcat cctgcagaca gatgatgcca cgctgggcaa 540 gctcatctac cccgtcggtt tctggaggag caaggtgaaa tacatcaagc agaccagcgc 600 catcctgcag cagcactacg gtggggacat cccagcctct gtggccgagc tggtggcgct 660 gccgggtgtt gggcccaaga tggcacacct ggctatggct gtggcctggg gcactgtgtc 720 aggcattgca gtggacacgc atgtgcacag aatcgccaac aggctgaggt ggaccaagaa 780 ggcaaccaag tccccagagg agacccgcgc cgccctggag gagtggctgc ctagggagct 840 gtggcacgag atcaatggac tcttggtggg cttcggccag cagacctgtc tgcctgtgca 900 ccctcgctgc cacgcctgcc tcaaccaagc cctctgcccg gccgcccagg gtctctgatg 960 gccgcatggc tctggccgag gtgccgctgt ggccaccgtc tgtgaagtgg ctttacgctt 1020 caggaagcca cgcctgttga ataaagcttt ggtgtgtttg c 1061 <210> 436 <211> 1028 <212> DNA <213> Homo sapiens <400> 436 ggagtccggc atgaccgcct tgagcgcgag gatgctgacc cggagccgga gcctgggacc 60 cggggctggg ccgcgggggt gtagggagga gcccgggcct ctccggagaa gagaggctgc 120 agcagaagcg aggaaaagcc acagccccgt gaagcgtccg cggaaagcac agagactgcg 180 tgtggcctat gagggctcgg acagtgagaa aggtgagggg gctgagcccc tcaaggtgcc 240 agtctgggag ccccaggact ggcagcaaca gctggtcaac atccgtgcca tgaggaacaa 300 aaaggatgca cctgtggacc atctggggac tgagcactgc tatgactcca gtgccccccc 360 aaaggtacgc aggtaccagg tgctgctgtc actgatgctc tccagccaaa ccaaagacca 420 ggtgacggcg ggcgccatgc agcgactgcg ggcgcggggc ctgacggtgg acagcatcct 480 gcagacagat gatgccacgc tgggcaagct catctacccc gtcggtttct ggaggagcaa 540 ggtgaaatac atcaagcaga ccagcgccat cctgcagcag cactacggtg gggacatccc 600 agcctctgtg gccgagctgg tggcgctgcc gggtgttggg cccaagatgg cacacctggc 660 tatggctgtg gcctggggca ctgtgtcagg cattgcagtg gacacgcatg tgcacagaat 720 cgccaacagg ctgaggtgga ccaagaaggc aaccaagtcc ccagaggaga cccgcgccgc 780 cctggaggag tggctgccta gggagctgtg gcacgagatc aatggactct tggtgggctt 840 cggccagcag acctgtctgc ctgtgcaccc tcgctgccac gcctgcctca accaagccct 900 ctgcccggcc gcccagggtc tctgatggcc gcatggctct ggccgaggtg ccgctgtggc 960 caccgtctgt gaagtggctt tacgcttcag gaagccacgc ctgttgaata aagctttggt 1020 gtgtttgc 1028 <210> 437 <211> 1045 <212> DNA <213> Homo sapiens <400> 437 agtccggcat gaccgccttg agcgcgagga tgctgacccg gagccggagc ctgggacccg 60 gggctgggcc gcgggggtgt agggaggagc ccgggcctct ccggagaaga gaggctgcag 120 cagaagcgag gaaaagccac agccccgtga agcgtccgcg gaaagcacag agactgcgtg 180 tggcctatga gggctcggac agtgagaaag gtgagggggc tgagcccctc aaggtgccag 240 tctgggagcc ccaggactgg cagcaacagc tggtcaacat ccgtgccatg aggaacaaaa 300 aggatgcacc tgtggaccat ctggggactg agcactgcta tgactccagt gcccccccaa 360 aggtacgcag gtaccaggtg ctgctgtcac tgatgctctc cagccaaacc aaagaccagg 420 tgacggcggg cgccatgcag cgactgcggg cgcggggcct gacggtggac agcatcctgc 480 agacagatga tgccacgctg ggcaagctca tctaccccgt cggtttctgg aggagcaagg 540 tgaaatacat caagcagacc agcgccatcc tgcagcagca ctacggtggg gacatcccag 600 cctctgtggc cgagctggtg gcgctgccgg gtgttgggcc caagatggca cacctggcta 660 tggctgtggc ctggggcact gtgtcaggca ttgcagtgga cacgcatgtg cacagaatcg 720 ccaacaggct gaggtggacc aagaaggcaa ccaagtcccc agaggagacc cgcgccgccc 780 tggaggagtg gctgcctagg gagctgtggc acgagatcaa tggactcttg gtgggcttcg 840 gccagcagac ctgtctgcct gtgcaccctc gctgccacgc ctgcctcaac caagccctct 900 gcccggccgc ccagggtctc tgatggccgc atggctctgg ccgaggtgcc gctgtggcca 960 ccgtctgtga agtggcttta cgcttcagga agccacgcct gttgaataaa gctttggtgt 1020 gtttgcaaaa aaaaaaaaaa aaaaa 1045 <210> 438 <211> 1056 <212> DNA <213> Homo sapiens <400> 438 ggcatgaccg ccttgagcgc gaggatgctg acccggagcc ggagcctggg acccggggct 60 gggccgcggg ggtgtaggga ggagcccggg cctctccgga gaagagaggc tgcagcagaa 120 gcgaggaaaa gccacagccc cgtgaagcgt ccgcggaaag cacagagact gcgtgtggcc 180 tatgagggct cggacagtga gaaaggtgag ggggctgagc ccctcaaggt gccagtctgg 240 gagccccagg actggcagca acagctggtc aacatccgtg ccatgaggaa caaaaaggat 300 gcacctgtgg accatctggg gactgagcac tgctatgact ccagtgcccc cccaaaggta 360 cgcaggtacc aggtgctgct gtcactgatg ctctccagcc aaaccaaaga ccaggtgacg 420 gcgggcgcca tgcagcgact gcgggcgcgg ggcctgacgg tggacagcat cctgcagaca 480 gatgatgcca cgctgggcaa gctcatctac cccgtcggtt tctggaggag caaggtgaaa 540 tacatcaagc agaccagcgc catcctgcag cagcactacg gtggggacat cccagcctct 600 gtggccgagc tggtggcgct gccgggtgtt gggcccaaga tggcacacct ggctatggct 660 gtggcctggg gcactgtgtc aggcattgca gtggacacgc atgtgcacag aatcgccaac 720 aggctgaggt ggaccaagaa ggcaaccaag tccccagagg agacccgcgc cgccctggag 780 gagtggctgc ctagggagct gtggcacgag atcaatggac tcttggtggg cttcggccag 840 cagacctgtc tgcctgtgca ccctcgctgc cacgcctgcc tcaaccaagc cctctgcccg 900 gccgcccagg gtctctgatg gccgcatggc tctggccgag gtgccgctgt ggccaccgtc 960 tgtgaagtgg ctttacgctt caggaagcca cgcctgttga ataaagcttt ggtgtgtttg 1020 cagatggaaa aaaaaaaaaa aaaaaaaaaa aaaaaa 1056 <210> 439 <211> 1057 <212> DNA <213> Homo sapiens <400> 439 ggcatgaccg ccttgagcgc gaggatgctg acccggagcc ggagcctggg acccggggct 60 gggccgcggg ggtgtaggga ggagcccggg cctctccgga gaagagaggc tgcagcagaa 120 gcgaggaaaa gccacagccc cgtgaagcgt ccgcggaaag cacagagact gcgtgtggcc 180 tatgagggct cggacagtga gaaaggtgag ggggctgagc ccctcaaggt gccagtctgg 240 gagccccagg actggcagca acagctggtc aacatccgtg ccatgaggaa caaaaaggat 300 gcacctgtgg accatctggg gactgagcac tgctatgact ccagtgcccc cccaaaggta 360 cgcaggtacc aggtgctgct gtcactgatg ctctccagcc aaaccaaaga ccaggtgacg 420 gcgggcgcca tgcagcgact gcgggcgcgg ggcctgacgg tggacagcat cctgcagaca 480 gatgatgcca cgctgggcaa gctcatctac cccgtcggtt tctggaggag caaggtgaaa 540 tacatcaagc agaccagcgc catcctgcag cagcactacg gtggggacat cccagcctct 600 gtggccgagc tggtggcgct gccgggtgtt gggcccaaga tggcacacct ggctatggct 660 gtggcctggg gcactgtgtc aggcattgca gtggacacgc atgtgcacag aatcgccaac 720 aggctgaggt ggaccaagaa ggcaaccaag tccccagagg agacccgcgc cgccctggag 780 gagtggctgc ctagggagct gtggcacgag atcaatggac tcttggtggg cttcggccag 840 cagacctgtc tgcctgtgca ccctcgctgc cacgcctgcc tcaaccaagc cctctgcccg 900 gccgcccagg gtctctgatg gccgcatggc tctggccgag gtgccgctgt ggccaccgtc 960 tgtgaagtgg ctttacgctt caggaagcca cgcctgttga ataaagcttt ggtgtgtttg 1020 cagatggaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa 1057 <210> 440 <211> 1030 <212> DNA <213> Homo sapiens <400> 440 acgagcgcct tgagcgcgag gatgctgacc cggagccgga gcctgggacc cggggctggg 60 ccgcgggggt gtagggagga gcccgggcct ctccggagaa gagaggctgc agcagaagcg 120 aggaaaagcc acagccccgt gaagcgtccg cggaaagcac agagactgcg tgtggcctat 180 gagggctcgg acagtgagaa aggtgaggct gagcccctca aggtgccagt ctgggagccc 240 caggactggc agcaacagct ggtcaacatc cgtgccatga ggaacaaaaa ggatgcacct 300 gtggaccatc tggggactga gcactgctat gactccagtg cccccccaaa ggtacgcagg 360 taccaggtgc tgctgtcact gatgctctcc agccaaacca aagaccaggt gacggcgggc 420 gccatgcagc gactgcgggc gcggggcctg acggtggaca gcatcctgca gacagatgat 480 gccacgctgg gcaagctcat ctaccccgtc ggtttctgga ggagcaaggt gaaatacatc 540 aagcagacca gcgccatcct gcagcagcac tacggtgggg acatcccagc ctctgtggcc 600 gagctggtgg cgctgccggg tgttgggccc aagatggcac acctggctat ggctgtggcc 660 tggggcactg tgtcaggcat tgcagtggac acgcatgtgc acagaatcgc caacaggctg 720 aggtggacca agaaggcaac caagtcccca gaggagaccc gcgccgccct ggaggagtgg 780 ctgcctaggg agctgtggca cgagatcaat ggactcttgg tgggcttcgg ccagcagacc 840 tgtctgcctg tgcaccctcg ctgccacgcc tgcctcaacc aagccctctg cccggccgcc 900 cagggtctct gatggccgca tggctctggc cgaggtgccg ctgtggccac cgtctgtgaa 960 gtggctttac gcttcaggaa gccacgcctg ttgaataaag ctttggtgtg tttgcaaaaa 1020 aaaaaaaaaa 1030 <210> 441 <211> 2187 <212> DNA <213> Homo sapiens <400> 441 tagcggtgct gggtcgggcc gacgtgccac ccacccggag ccgggatgcc agaagggccg 60 ttggtgagga aatttcacca tttggtctcc ccctttgtgg gtcagcaggt ggtcaagaca 120 gggggcagca gtaagaagct acagcccgcc agcctgcagt ctctgtggct ccaggacacc 180 caggtccatg gaaagaaatt attccttaga tttgatctag atgaagaaat ggggccccct 240 ggcagcagcc caacaccaga gcctccacaa aaagaagtgc agaaggaagg ggctgcggac 300 ccaaagcagg tcggggagcc cagcgggcag aagacccttg atggatcctc acggtctgca 360 gagctcgtcc cccagggcga ggatgattct gagtatttgg agagagacgc ccctgcagga 420 gatgctggga ggtggctgcg tgtcagcttt ggtttgtttg gcagcgtttg ggtgaacgat 480 ttctccagag ccaagaaagc caacaagagg ggggactgga gggacccttc cccgaggttg 540 gtcctgcact ttggtggtgg tggcttcctg gcattttata attgtcagtt gtcttggagc 600 tcttccccgg tggtcacacc cacctgtgac atcctgtctg agaagttcca tcgaggacaa 660 gccttagaag ctctaggcca ggctcagcct gtctgctata cactgctgga ccagagatac 720 ttctcagggc tagggaacat cattaagaat gaagccttgt acagagctgg gatccatccc 780 ctttctctcg gttcagtcct gagtgcctcg cgtcgggagg tcctggtgga tcacgtggtg 840 gagttcagta cagcctggct gcagggcaag ttccaaggca gaccgcagca cacacaggtc 900 taccagaaag aacagtgccc tgctggccac caggtcatga aggaggcgtt tgggcccgaa 960 gatgggttac agaggctcac ctggtggtgc ccgcagtgcc agccccagtt gtcagaggag 1020 ccagagcagt gccagttctc ctaaggagct ggtggtgctc ctcatggaac cttgccgttg 1080 gggaacctga cgtctaagtg tccagaaagg aggatgtggg cagggacggg gtacagagga 1140 tagtgtgggt cagaggtgcc agtagtataa tattcatctc cctggagtta tgttgaaggc 1200 agagttttca tagggttaga ttttttttat ccttttctag ttcagttaat tcatcctgtt 1260 gaattgcacc atcgtgaaag atgggaaaaa tcgtgatgat gggtaagggg aaaacttccc 1320 ggaaggcaat ggggcaagga aaaagaaagc ctatgggaaa tggctgtgct cccaacatag 1380 ctttgcagat gatgtgggtt tttttttttt ttttttggtt gtttgttttg agagagagtc 1440 ttgctctgtc tccctggcta gggtgtggtg gtgtgatctt ggctcacggc agccttgccc 1500 tccctggctc aagcagtctt catctcagcc tccagagtag ctgggactac aggcatgtga 1560 tatgatgctc ggctgatttt tgtttacttt ttagagagat ggggtcttgc catatttgcc 1620 aggctggttt gaactcctac aactcaagca ttcctcccac cttggtctcc caaaatgttg 1680 ggaccacggg tgtgagccac cgcgcccagc tagctcctgt gttttgtttt tgttttgtaa 1740 ctttggttga tgttaaggcc ctccattttg gaaagcagga aaacaggatt tttttttttt 1800 atcttgttcc ctggaggatc cagggatgag gatagagtgg cctgagagca gtgcttggat 1860 tcagcctcct gctgggtcct tctgctggat acaggcacca agaggcgggg gtggagcagg 1920 gagctgcgcc ttcctggggt gcccggtggt gtgtagagaa aagctgcttg tttactcctt 1980 aagtcaatgt attggtgact gttgatttgt tgaacaattc aggaatcaag ggctgtggag 2040 aaactccctc atgttgttgg caacaggtga atgaacctag agcggtgaca tgaaaataaa 2100 gctcactgtt actcgcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2160 aaaaaaaaaa aaaaaaaaaa aaaaaaa 2187 <210> 442 <211> 2187 <212> DNA <213> Homo sapiens <400> 442 tagcggtgct gggtcgggcc gacgtgccac ccacccggag ccgggatgcc agaagggccg 60 ttggtgagga aatttcacca tttggtctcc ccctttgtgg gtcagcaggt ggtcaagaca 120 gggggcagca gtaagaagct acagcccgcc agcctgcagt ctctgtggct ccaggacacc 180 caggtccatg gaaagaaatt attccttaga tttgatctag atgaagaaat ggggccccct 240 ggcagcagcc caacaccaga gcctccacaa aaagaagtgc agaaggaagg ggctgcggac 300 ccaaagcagg tcggggagcc cagcgggcag aagacccttg atggatcctc acggtctgca 360 gagctcgtcc cccagggcga ggatgattct gagtatttgg agagagacgc ccctgcagga 420 gatgctggga ggtggctgcg tgtcagcttt ggtttgtttg gcagcgtttg ggtgaacgat 480 ttctccagag ccaagaaagc caacaagagg ggggactgga gggacccttc cccgaggttg 540 gtcctgcact ttggtggtgg tggcttcctg gcattttata attgtcagtt gtcttggagc 600 tcttccccgg tggtcacacc cacctgtgac atcctgtctg agaagttcca tcgaggacaa 660 gccttagaag ctctaggcca ggctcagcct gtctgctata cactgctgga ccagagatac 720 ttctcagggc tagggaacat cattaagaat gaagccttgt acagagctgg gatccatccc 780 ctttctctcg gttcagtcct gagtgcctcg cgtcgggagg tcctggtgga tcacgtggtg 840 gagttcagta cagcctggct gcagggcaag ttccaaggca gaccgcagca cacacaggtc 900 taccagaaag aacagtgccc tgctggccac caggtcatga aggaggcgtt tgggcccgaa 960 gatgggttac agaggctcac ctggtggtgc ccgcagtgcc agccccagtt gtcagaggag 1020 ccagagcagt gccagttctc ctaaggagct ggtggtgctc ctcatggaac cttgccgttg 1080 gggaacctga cgtctaagtg tccagaaagg aggatgtggg cagggacggg gtacagagga 1140 tagtgtgggt cagaggtgcc agtagtataa tattcatctc cctggagtta tgttgaaggc 1200 agagttttca tagggttaga ttttttttat ccttttctag ttcagttaat tcatcctgtt 1260 gaattgcacc atcgtgaaag atgggaaaaa tcgtgatgat gggtaagggg aaaacttccc 1320 ggaaggcaat ggggcaagga aaaagaaagc ctatgggaaa tggctgtgct cccaacatag 1380 ctttgcagat gatgtgggtt tttttttttt ttttttggtt gtttgttttg agagagagtc 1440 ttgctctgtc tccctggcta gggtgtggtg gtgtgatctt ggctcacggc agccttgccc 1500 tccctggctc aagcagtctt catctcagcc tccagagtag ctgggactac aggcatgtga 1560 tatgatgctc ggctgatttt tgtttacttt ttagagagat ggggtcttgc catatttgcc 1620 aggctggttt gaactcctac aactcaagca ttcctcccac cttggtctcc caaaatgttg 1680 ggaccacggg tgtgagccac cgcgcccagc tagctcctgt gttttgtttt tgttttgtaa 1740 ctttggttga tgttaaggcc ctccattttg gaaagcagga aaacaggatt tttttttttt 1800 atcttgttcc ctggaggatc cagggatgag gatagagtgg cctgagagca gtgcttggat 1860 tcagcctcct gctgggtcct tctgctggat acaggcacca agaggcgggg gtggagcagg 1920 gagctgcgcc ttcctggggt gcccggtggt gtgtagagaa aagctgcttg tttactcctt 1980 aagtcaatgt attggtgact gttgatttgt tgaacaattc aggaatcaag ggctgtggag 2040 aaactccctc atgttgttgg caacaggtga atgaacctag agcggtgaca tgaaaataaa 2100 gctcactgtt actcgcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2160 aaaaaaaaaa aaaaaaaaaa aaaaaaa 2187 <210> 443 <211> 2661 <212> DNA <213> Homo sapiens <400> 443 gtagcggtgc tgggtcgggc cgacgtgcca cccacccgga gccggtgagt gcagccgccc 60 gccctccggt agatctgcgg cctggcggag aagtcgggag gggacaggaa gggagggcgg 120 gccccgggcc ctcctccgtc tcagccgcct gcggaggtgc tgcccacgcc tggaggcccc 180 cactgaccct cagacccgcg tctgcgcccc tctccccgca ccccgaggca gagttgggaa 240 agcagtggtc ttagaccccc cacctcgggc actcggaaga gaacggcgga gacaacccct 300 cctcttccct ggctggcgca gcgccagcct cgagctcctc ggtagccccc gggcagggag 360 ggcccgaggg tgggcgcggc atcttcagcg actcttcgaa gtcccttccg cgtctcatct 420 ttcaaggctg ttgcagaggc ggcttgcttc ccacctgtcc atctccataa aaatccctaa 480 acgaaacatg cccacgtgtc cggagatttt caggacttgg tgcatttcag atgaaggctt 540 ttccagaagc ttccccgtag aagaggatca ggcatccaac tggttaaggg atgccagaag 600 ggccgttggt gaggaaattt caccatttgg tctccccctt tgtgggtcag caggtggtca 660 agacaggggg cagcagtaag aagctacagc ccgccagcct gcagtctctg tggctccagg 720 acacccaggt ccatggaaag aaattattcc ttagatttga tctagatgaa gaaatggggc 780 cccctggcag cagcccaaca ccagagcctc cacaaaaaga agtgcagaag gaaggggctg 840 cggacccaaa gcaggtcggg gagcccagcg ggcagaagac ccttgatgga tcctcacggt 900 ctgcagagct cgtcccccag ggcgaggatg attctgagta tttggagaga gacgcccctg 960 caggagatgc tgggaggtgg ctgcgtgtca gctttggttt gtttggcagc gtttgggtga 1020 acgatttctc cagagccaag aaagccaaca agagggggga ctggagggac ccttccccga 1080 ggttggtcct gcactttggt ggtggtggct tcctggcatt ttataattgt cagttgtctt 1140 ggagctcttc cccggtggtc acacccacct gtgacatcct gtctgagaag ttccatcgag 1200 gacaagcctt agaagctcta ggccaggctc agcctgtctg ctatacactg ctggaccaga 1260 gatacttctc agggctaggg aacatcatta agaatgaagc cttgtacaga gctgggatcc 1320 atcccctttc tctcggttca gtcctgagtg cctcgcgtcg ggaggtcctg gtggatcacg 1380 tggtggagtt cagtacagcc tggctgcagg gcaagttcca aggcagaccg cagcacacac 1440 aggtctacca gaaagaacag tgccctgctg gccaccaggt catgaaggag gcgtttgggc 1500 ccgaagatgg gttacagagg ctcacctggt ggtgcccgca gtgccagccc cagttgtcag 1560 aggagccaga gcagtgccag ttctcctaag gagctggtgg tgctcctcat ggaaccttgc 1620 cgttggggaa cctgacgtct aagtgtccag aaaggaggat gtgggcaggg acggggtaca 1680 gaggatagtg tgggtcagag gtgccagtag tataatattc atctccctgg agttatgttg 1740 aaggcagagt tttcataggg ttagattttt tttatccttt tctagttcag ttaattcatc 1800 ctgttgaatt gcaccatcgt gaaagatggg aaaaatcgtg atgatgggta aggggaaaac 1860 ttcccggaag gcaatggggc aaggaaaaag aaagcctatg ggaaatggct gtgctcccaa 1920 catagctttg cagatgatgt gggttttttt tttttttttt ggttgtttgt tttgagagag 1980 agtcttgctc tgtctccctg gctagggtgt ggtggtgtga tcttggctca cggcagcctt 2040 gccctccctg gctcaagcag tcttcatctc agcctccaga gtagctggga ctacaggcat 2100 gtgatatgat gctcggctga tttttgttta ctttttagag agatggggtc ttgccatatt 2160 tgccaggctg gtttgaactc ctacaactca agcattcctc ccaccttggt ctcccaaaat 2220 gttgggacca cgggtgtgag ccaccgcgcc cagctagctc ctgtgttttg tttttgtttt 2280 gtaactttgg ttgatgttaa ggccctccat tttggaaagc aggaaaacag gatttttttt 2340 tttttatctt gttccctgga ggatccaggg atgaggatag agtggcctga gagcagtgct 2400 tggattcagc ctcctgctgg gtccttctgc tggatacagg caccaagagg cgggggtgga 2460 gcagggagct gcgccttcct ggggtgcccg gtggtgtgta gagaaaagct gcttgtttac 2520 tccttaagtc aatgtattgg tgactgttga tttgttgaac aattcaggaa tcaagggctg 2580 tggagaaact ccctcatgtt gttggcaaca ggtgaatgaa cctagagcgg tgacatgaaa 2640 ataaagctca ctgttactcg c 2661 <210> 444 <211> 2661 <212> DNA <213> Homo sapiens <400> 444 gtagcggtgc tgggtcgggc cgacgtgcca cccacccgga gccggtgagt gcagccgccc 60 gccctccggt agatctgcgg cctggcggag aagtcgggag gggacaggaa gggagggcgg 120 gccccgggcc ctcctccgtc tcagccgcct gcggaggtgc tgcccacgcc tggaggcccc 180 cactgaccct cagacccgcg tctgcgcccc tctccccgca ccccgaggca gagttgggaa 240 agcagtggtc ttagaccccc cacctcgggc actcggaaga gaacggcgga gacaacccct 300 cctcttccct ggctggcgca gcgccagcct cgagctcctc ggtagccccc gggcagggag 360 ggcccgaggg tgggcgcggc atcttcagcg actcttcgaa gtcccttccg cgtctcatct 420 ttcaaggctg ttgcagaggc ggcttgcttc ccacctgtcc atctccataa aaatccctaa 480 acgaaacatg cccacgtgtc cggagatttt caggacttgg tgcatttcag atgaaggctt 540 ttccagaagc ttccccgtag aagaggatca ggcatccaac tggttaaggg atgccagaag 600 ggccgttggt gaggaaattt caccatttgg tctccccctt tgtgggtcag caggtggtca 660 agacaggggg cagcagtaag aagctacagc ccgccagcct gcagtctctg tggctccagg 720 acacccaggt ccatggaaag aaattattcc ttagatttga tctagatgaa gaaatggggc 780 cccctggcag cagcccaaca ccagagcctc cacaaaaaga agtgcagaag gaaggggctg 840 cggacccaaa gcaggtcggg gagcccagcg ggcagaagac ccttgatgga tcctcacggt 900 ctgcagagct cgtcccccag ggcgaggatg attctgagta tttggagaga gacgcccctg 960 caggagatgc tgggaggtgg ctgcgtgtca gctttggttt gtttggcagc gtttgggtga 1020 acgatttctc cagagccaag aaagccaaca agagggggga ctggagggac ccttccccga 1080 ggttggtcct gcactttggt ggtggtggct tcctggcatt ttataattgt cagttgtctt 1140 ggagctcttc cccggtggtc acacccacct gtgacatcct gtctgagaag ttccatcgag 1200 gacaagcctt agaagctcta ggccaggctc agcctgtctg ctatacactg ctggaccaga 1260 gatacttctc agggctaggg aacatcatta agaatgaagc cttgtacaga gctgggatcc 1320 atcccctttc tctcggttca gtcctgagtg cctcgcgtcg ggaggtcctg gtggatcacg 1380 tggtggagtt cagtacagcc tggctgcagg gcaagttcca aggcagaccg cagcacacac 1440 aggtctacca gaaagaacag tgccctgctg gccaccaggt catgaaggag gcgtttgggc 1500 ccgaagatgg gttacagagg ctcacctggt ggtgcccgca gtgccagccc cagttgtcag 1560 aggagccaga gcagtgccag ttctcctaag gagctggtgg tgctcctcat ggaaccttgc 1620 cgttggggaa cctgacgtct aagtgtccag aaaggaggat gtgggcaggg acggggtaca 1680 gaggatagtg tgggtcagag gtgccagtag tataatattc atctccctgg agttatgttg 1740 aaggcagagt tttcataggg ttagattttt tttatccttt tctagttcag ttaattcatc 1800 ctgttgaatt gcaccatcgt gaaagatggg aaaaatcgtg atgatgggta aggggaaaac 1860 ttcccggaag gcaatggggc aaggaaaaag aaagcctatg ggaaatggct gtgctcccaa 1920 catagctttg cagatgatgt gggttttttt tttttttttt ggttgtttgt tttgagagag 1980 agtcttgctc tgtctccctg gctagggtgt ggtggtgtga tcttggctca cggcagcctt 2040 gccctccctg gctcaagcag tcttcatctc agcctccaga gtagctggga ctacaggcat 2100 gtgatatgat gctcggctga tttttgttta ctttttagag agatggggtc ttgccatatt 2160 tgccaggctg gtttgaactc ctacaactca agcattcctc ccaccttggt ctcccaaaat 2220 gttgggacca cgggtgtgag ccaccgcgcc cagctagctc ctgtgttttg tttttgtttt 2280 gtaactttgg ttgatgttaa ggccctccat tttggaaagc aggaaaacag gatttttttt 2340 tttttatctt gttccctgga ggatccaggg atgaggatag agtggcctga gagcagtgct 2400 tggattcagc ctcctgctgg gtccttctgc tggatacagg caccaagagg cgggggtgga 2460 gcagggagct gcgccttcct ggggtgcccg gtggtgtgta gagaaaagct gcttgtttac 2520 tccttaagtc aatgtattgg tgactgttga tttgttgaac aattcaggaa tcaagggctg 2580 tggagaaact ccctcatgtt gttggcaaca ggtgaatgaa cctagagcgg tgacatgaaa 2640 ataaagctca ctgttactcg c 2661 <210> 445 <211> 999 <212> DNA <213> Homo sapiens <400> 445 atgccagaag ggccgttggt gaggaaattt caccatttgg tctccccctt tgtgggtcag 60 caggtggtca agacaggggg cagcagtaag aagctacagc ccgccagcct gcagtctctg 120 tggctccagg acacccaggt ccatggaaag aaattattcc ttagatttga tctagatgaa 180 gaaatggggc cccctggcag cagcccaaca ccagagcctc cacaaaaaga agtgcagaag 240 gaaggggctg cggacccaaa gcaggtcggg gagcccagcg ggcagaagac ccttgatgga 300 tcctcacagt ctgcagagct cgtcccccag ggcgaggatg attctgagta tttggagaga 360 gacgcccctg caggagatgc tgggaggtgg ctgcgtgtca gctttggttt gtttggcagc 420 gtttgggtga acgatttctc cagagccaag aaagccaaca agagggggga ctggagggac 480 ccttccccga ggttggtcct gcactttggt ggtggtggct tcctggcatt ttataattgt 540 cagttgtctt ggagctcttc cccagtggtc acacccacct gtgacatcct gtctgagaag 600 ttccatcgag gacaagcctt agaagctcta ggccaggctc agcctgtctg ctatacactg 660 ctggaccaga gatacttctc agggctaggg aacatcatta agaatgaagc cttgtacaga 720 gctgggatcc atcccctttc tctcggttca gtcctgagtg cctcgcgtcg ggaggtcctg 780 gtggatcacg tggtggagtt cagtacagcc tggctgcagg gcaagttcca aggcagaccg 840 cagcacacac aggtctacca gaaagaacag tgccctgctg gccaccaggt catgaaggag 900 gcgtttgggc ccgaagatgg gttacagagg ctcacctggt ggtgcccgca gtgccagccc 960 cagttgtcag aggagccaga gcagtgccag ttctcctaa 999 <210> 446 <211> 2015 <212> DNA <213> Homo sapiens <400> 446 gaaatctccg cccccagctg gagcggctgt gcgggctgcg tagcggtgct gggtcgggcc 60 gacgtgccac ccacccggag ccggtccatg gaaagaaatt attccttaga tttgatctag 120 atgaagaaat ggggccccct ggcagcagcc caacaccaga gcctccacaa aaagaagtgc 180 agaaggaagg ggctgcggac ccaaagcagg tcggggagcc cagcgggcag aagacccttg 240 atggatcctc acggtctgca gagctcgtcc cccagggcga ggatgattct gagtatttgg 300 agagagacgc ccctgcagga gatgctggga ggtggctgcg tgtcagcttt ggtttgtttg 360 gcagcgtttg ggtgaacgat ttctccagag ccaagaaagc caacaagagg ggggactgga 420 gggacccttc cccgaggttg gtcctgcact ttggtggtgg tggcttcctg gcattttata 480 attgtcagtt gtcttggagc tcttccccgg tggtcacacc cacctgtgac atcctgtctg 540 agaagttcca tcgaggacaa gccttagaag ctctaggcca ggctcagcct gtctgctata 600 cactgctgga ccagagatac ttctcagggc tagggaacat cattaagaat gaagccttgt 660 acagagctgg gatccatccc ctttctctcg gttcagtcct gagtgcctcg cgtcgggagg 720 tcctggtgga tcacgtggtg gagttcagta cagcctggct gcagggcaag ttccaaggca 780 gaccgcagca cacacaggtc taccagaaag aacagtgccc tgctggccac caggtcatga 840 aggaggcgtt tgggcccgaa gatgggttac agaggctcac ctggtggtgc ccgcagtgcc 900 agccccagtt gtcagaggag ccagagcagt gccagttctc ctaaggagct ggtggtgctc 960 ctcatggaac cttgccgttg gggaacctga cgtctaagtg tccagaaagg aggatgtggg 1020 cagggacggg gtacagagga tagtgtgggt cagaggtgcc agtagtataa tattcatctc 1080 cctggagtta tgttgaaggc agagttttca tagggttaga ttttttttat ccttttctag 1140 ttcagttaat tcatcctgtt gaattgcacc atcgtgaaag atgggaaaaa tcgtgatgat 1200 gggtaagggg aaaacttccc ggaaggcaat ggggcaagga aaaagaaagc ctatgggaaa 1260 tggctgtgct cccaacatag ctttgcagat gatgtgggtt tttttttttt ttttggttgt 1320 ttgttttgag agagagtctt gctctgtctc cctggctggg gtgtggtggt gtgatcttgg 1380 ctcacggcag ccttgccctc cctggctcaa gcagtcttca tctcagcctc cagagtagct 1440 gggactacag gcatgtgata tgatgctcgg ctgatttttg tttacttttt agagagatgg 1500 ggtcttgcca tatttgccag gctggtttga actcctacaa ctcaagcatt cctcccacct 1560 tggtctccca aaatgttggg accacgggtg tgagccaccg cgcccagcta gctcctgtgt 1620 tttgtttttg ttttgtaact ttggttgatg ttaaggccct ccattttgga aagcaggaaa 1680 acaggatttt ttttttttta tcttgttccc tggaggatcc agggatgagg atagagtggc 1740 ctgagagcag tgcttggatt cagcctcctg ctgggtcctt ctgctggata caggcaccaa 1800 gaggcggggg tggagcaggg agctgcgcct tcctggggtg cccggtggtg tgtagagaaa 1860 agctgcttgt ttactcctta agtcaatgta ttggtgactg ttgatttgtt gaacaattca 1920 ggaatcaagg gctgtggaga aactccctca tgttgttggc aacaggtgaa tgaacctaga 1980 gcggtgacat gaaaataaag ctcactgtta ctcgc 2015 <210> 447 <211> 2091 <212> DNA <213> Homo sapiens <400> 447 ggtaggggtg ctgggtcggg ccgacgtgcc acccacccgg agccgggatg ccagaagggc 60 cgttggtgag gaaatttcac catttggtct ccccctttgt gggtcagcag gtggtcaaga 120 cagggggcag cagtaagaag ctacagcccg ccagcctgca gtctctgtgg ctccaggaca 180 cccaggtcca tggaaagaaa ttattcctta gatttgatct agatgaagaa atggggcccc 240 ctggcagcag cccaacacca gagcctccac aaaaagaagt gcagaagacc cttgatggat 300 cctcacggtc tgcagagctc gtcccccagg gcgaggatga ttctgagtat ttggagagag 360 acgcccctgc aggagatgct gggaggtggc tgcgtgtcag ctttggtttg tttggcagcg 420 tttgggtgaa cgatttctcc agagccaaga aagccaacaa gaggggggac tggagggacc 480 cttccccgag gttggtcctg cactttggtg gtggtggctt cctggcattt tataattgtc 540 agttgtcttg gagctcttcc ccagtggtca cacccacctg tgacatcctg tctgagaagt 600 tccatcgagg acaagcctta gaagctctag gccaggctca gcctgtctgc tatacactgc 660 tggaccagag atacttctca gggctaggga acatcattaa gaatgaagcc ttgtacagag 720 ctgggatcca tcccctttct ctcggttcag tcctgagtgc ctcgcgtcgg gaggtcctgg 780 tggatcacgt ggtggagttc agtacagcct ggctgcaggg caagttccaa ggcagaccgc 840 agcacacaca ggtctaccag aaagaacagt gccctgctgg ccaccaggtc atgaaggagg 900 cgtttgggcc cgaagatggg ttacagaggc tcacctggtg gtgcccgcag tgccagcccc 960 agttgtcaga ggagccagag cagtgccagt tctcctaagg agctggtggt gctcctcacg 1020 gaaccttgcc gcttggggaa cctgacgtct aagtgtccag aaaggaggat gtgggcaggg 1080 acggggtaca gaggatagtg tgggtcagag gtgccagtag tataatattc gtctccctgg 1140 agttatgttg aaggcagagt tttcataggg ttagattttt tttatccctt tctagttcag 1200 ttaattcatc ctgttgaatt gcaccatcgt gaaagatggg aaaaatcgtg atgatgggta 1260 aggggaaaac ttcccggaag gcaatggggc aaggaaaaag aaagcctatg ggaaatggct 1320 gtgctcccaa catagctttg cagatgatgt gggttttttt tttttttttt ctggttgttt 1380 gttttgagag agagtcttgc tctgtctccc tggctagggt gtggtggtgt gatcttggct 1440 cacggcagtc ttgccctccc tggctcaagc agtcttcatc tcagcctcca gagtagctgg 1500 gactacaggc atgtgatatg atgctcggct gatttttgtt tactttttag agagatgggg 1560 tcttgccata tttgccaggc tggtttgaac tcctacaact caagcattcc tcccaccttg 1620 gtctcccaaa atgttgggac cacgggtgtg agccaccgcg cccagctagc tcctgtgttt 1680 tgtttttgtt ttgtaacttt ggttgatgtt aaggccctcc attttggaaa gcaggaaaac 1740 aggatttttt ttttttatct tgttccctgg aggatccagg gatgaggatg gagtggcctg 1800 agagcagtgc ttggattcag cctcctgctg ggtccttctg ctggatacag gcaccaagag 1860 gcgggggtgg agcagggagc tgcgccttcc tggggtgccc ggtggtgtgt agagaaaagc 1920 tgcttgttta ctccttaagt caatgtattg gtgactgttg atttgttgaa caattcagga 1980 atcaagggct gtggagaaac tccctcatgt tgttggcaac aggtgaatga acctagagcg 2040 gtgacatgaa aataaagctc actgttactc gcaaaaaaaa aaaaaaaaaa a 2091 <210> 448 <211> 1327 <212> DNA <213> Homo sapiens <400> 448 cgcgtcggga ggtcctggtg gatcacgtgg tggagttcag tacagcctgg ctgcagggca 60 agttccaagg cagaccgcag cacacacagg tctaccagaa agaacagtgc cctgctggcc 120 accaggtcat gaaggaggcg tttgggcccg aagatgggtt acagaggctc acctggtggt 180 gcccgcagtg ccagccccag ttgtcagagg agccagagca gtgccagttc tcctaaggag 240 ctggtggtgc tcctcacgga accttgccgc ttggggaacc tgacgtctaa gtgtccagaa 300 aggaggatgt gggcagggac ggggtacaga ggatagtgtg ggtcagaggt gccagtagta 360 taatattcat ctccctggag ttatgttgaa ggcagagttt tcatagggtt agattttttt 420 ttatcctttt ctagttcagt taattcatcc tgttgaattg caccatcgtg aaagatggga 480 aaaatcgtga tgatgggtaa ggggaaaact tcccggaagg caatggggca aggaaaaaga 540 aagcctatgg gaaatggctg tgctcccaac atagctttgc agatgatgtg ggcttttttt 600 tttttttttt tggttgtttg ttttgagaga gagtcttgct ctgtctccct ggctagggtg 660 tggtggtgtg atcttggctc acggcagcct tgccctccct ggctcaagca gtcttcatct 720 cagcctccag agtagctggg actacaggca tgtgatatga tgctcggctg atttttgttt 780 actttttaga gagatggggt cttgccatat ttgccaggct ggtttgaact cctacaactc 840 aagcattcct cccaccttgg tctcccaaaa tgttgggacc acgggtgtga gccaccgcgc 900 ccagctagct cctgtgtttt gtttttgttt tgtaactttg gttgatgtta aggccctcca 960 ttttggaaag caggaaaaca ggattttttt tttttatctt gttccctgga ggatccaggg 1020 atgaggatag agtggcctga gagcagtgct tggattcagc ctcctgctgg gtccttctgc 1080 tggatacagg caccaagagg cgggggtgga gcagggagct gcgccttcct ggggtgcccg 1140 gtggtgtgta gagaaaagct gcttgtttac tccttaagtc aatgtattgg tgactgttga 1200 tttgttggac aattcaggaa tcaagggctg tggagaaact ccctcatgtt gttggcaaca 1260 ggtgaatgaa cctagagcgg tgacatgaaa ataaagctca ctgttactcg caaaaaaaaa 1320 aaaaaaa 1327 <210> 449 <211> 2273 <212> DNA <213> Homo sapiens <400> 449 agtgcccgcg cagcgttgag ttgcacagcg gtattctcac caggccctgc aatcggtggg 60 ccacagtgcc ggccacagag atggtggaag gaccaggctg tactctgaat ggagagaaga 120 ttcgcgcgcg ggtgctcccg ggccaggcgg tgaccggcgt gcggggaagc gctctgcgga 180 gtccgcaggg ccgcgccttg cggctcgcag cctccacggt tgtggtctcc ccgcaggctg 240 ctgcactgaa taatgattcc agccagaatg tcttgagcct gtttaatgga tatgtttaca 300 gtggcgtgga aactttgggg aaggagctct ttatgtactt tggaccaaaa gctttacgga 360 ttcatttcgg aatgaaaggc ttcatcatga ttaatccact tgagtataaa tataaaaatg 420 gagcttctcc tgttttggaa gtgcagctca ccaaagattt gatttgtttc tttgactcat 480 cagtagaact cagaaactca atggaaagcc aacagagaat aagaatgatg aaagaattag 540 atgtatgttc acctgaattt agtttcttga gagcagaaag tgaagttaaa aaacagaaag 600 gccggatgct aggtgatgtg ctaatggatc agaacgtatt gcctggagta gggaacatca 660 tcaaaaatga agctctcttt gacagtggtc tccacccagc tgttaaagtt tgtcaattaa 720 cagatgaaca gatccatcac ctcatgaaaa tgatacgtga tttcagcatt ctcttttaca 780 ggtgccgtaa agcaggactt gctctctcta aacactataa ggtttacaag cgtcctaatt 840 gtggtcagtg ccactgcaga ataactgtgt gccgctttgg ggacaataac agaatgacat 900 atttctgtcc tcactgtcaa aaagaaaatc ctcaacatgt tgacatatgc aagctaccga 960 ctagaaatac tataatcagt tggacatcta gcagggtgga tcatgttatg gactccgtgg 1020 ctcggaagtc ggaagagcac tggacctgtg tggtgtgtac tttaatcaat aagccctctt 1080 ctaaggcatg tgatgcttgc ttgacctcaa ggcctattga ttcagtgctc aagagtgaag 1140 aaaattctac tgtctttagc cacttaatga agtacccgtg taatactttt ggaaaacctc 1200 atacagaagt caagatcaac aggaaaactg catttggaac tacaactctt gtcttgactg 1260 attttagcaa taaatccagt actttggaaa gaaaaacaaa gcaaaaccag atactagatg 1320 aggagtttca aaactctcct cctgctagtg tgtgtttgaa tgatatacag cacccctcca 1380 agaagacaac aaacgatata actcaactat ccagcaaagt aaacatatca cctacaatca 1440 gttcagaatc taaattattt agtccagcac ataaaaaacc gaaaacagcc cactactcat 1500 caccagagct taaaagctgc aaccctggat attctaacag tgaacttcaa attaatatga 1560 cagatggccc tcgtacctta aatcctgaca gccctcgctg cagtaaacac aaccgcctct 1620 gcatcctccg agttgtgagg aaggatgggg aaaacaaggg caggcagttt tatgcctgtc 1680 ctctacctag agaagcacaa tgtggatttt ttgaatgggc agatttgtcc ttcccattct 1740 gcaaccatgg caagcgttcc accatgaaaa cagtattgaa gattggacct aacaatggaa 1800 agaatttttt tgtgtgtcct cttgggaagg aaaaacaatg caattttttc cagtgggcag 1860 aaaatgggcc aggaataaaa attattcctg gatgctaata tctgtagatt ctctggcatt 1920 tagtctcttc aaactgtgta taatgtttgg tcctcctctg tttcatagaa aagtcataga 1980 atatctatga tacattgaaa agttactgca atatttgaga actgttcttt ttttttcttg 2040 tgtgtgccat ctttccattg ttggctacgt cttttctttt gccttgatga acgttctatg 2100 tatttcatcg gatatacagc atattccatt taggatgtgt atttaatgca tttagtaatg 2160 acgataaagt gtttttagta tgcttttagt ctcttgtaac tggggagaag cagtgttttt 2220 tttttaggaa aggattatgc gacacaataa aataagatat tctgtctgta gtg 2273 <210> 450 <211> 2273 <212> DNA <213> Homo sapiens <400> 450 agtgcccgcg cagcgttgag ttgcacagcg gtattctcac caggccctgc aatcggtggg 60 ccacagtgcc ggccacagag atggtggaag gaccaggctg tactctgaat ggagagaaga 120 ttcgcgcgcg ggtgctcccg ggccaggcgg tgaccggcgt gcggggaagc gctctgcgga 180 gtccgcaggg ccgcgccttg cggctcgcag cctccacggt tgtggtctcc ccgcaggctg 240 ctgcactgaa taatgattcc agccagaatg tcttgagcct gtttaatgga tatgtttaca 300 gtggcgtgga aactttgggg aaggagctct ttatgtactt tggaccaaaa gctttacgga 360 ttcatttcgg aatgaaaggc ttcatcatga ttaatccact tgagtataaa tataaaaatg 420 gagcttctcc tgttttggaa gtgcagctca ccaaagattt gatttgtttc tttgactcat 480 cagtagaact cagaaactca atggaaagcc aacagagaat aagaatgatg aaagaattag 540 atgtatgttc acctgaattt agtttcttga gagcagaaag tgaagttaaa aaacagaaag 600 gccggatgct aggtgatgtg ctaatggatc agaacgtatt gcctggagta gggaacatca 660 tcaaaaatga agctctcttt gacagtggtc tccacccagc tgttaaagtt tgtcaattaa 720 cagatgaaca gatccatcac ctcatgaaaa tgatacgtga tttcagcatt ctcttttaca 780 ggtgccgtaa agcaggactt gctctctcta aacactataa ggtttacaag cgtcctaatt 840 gtggtcagtg ccactgcaga ataactgtgt gccgctttgg ggacaataac agaatgacat 900 atttctgtcc tcactgtcaa aaagaaaatc ctcaacatgt tgacatatgc aagctaccga 960 ctagaaatac tataatcagt tggacatcta gcagggtgga tcatgttatg gactccgtgg 1020 ctcggaagtc ggaagagcac tggacctgtg tggtgtgtac tttaatcaat aagccctctt 1080 ctaaggcatg tgatgcttgc ttgacctcaa ggcctattga ttcagtgctc aagagtgaag 1140 aaaattctac tgtctttagc cacttaatga agtacccgtg taatactttt ggaaaacctc 1200 atacagaagt caagatcaac aggaaaactg catttggaac tacaactctt gtcttgactg 1260 attttagcaa taaatccagt actttggaaa gaaaaacaaa gcaaaaccag atactagatg 1320 aggagtttca aaactctcct cctgctagtg tgtgtttgaa tgatatacag cacccctcca 1380 agaagacaac aaacgatata actcaactat ccagcaaagt aaacatatca cctacaatca 1440 gttcagaatc taaattattt agtccagcac ataaaaaacc gaaaacagcc cactactcat 1500 caccagagct taaaagctgc aaccctggat attctaacag tgaacttcaa attaatatga 1560 cagatggccc tcgtacctta aatcctgaca gccctcgctg cagtaaacac aaccgcctct 1620 gcatcctccg agttgtgagg aaggatgggg aaaacaaggg caggcagttt tatgcctgtc 1680 ctctacctag agaagcacaa tgtggatttt ttgaatgggc agatttgtcc ttcccattct 1740 gcaaccatgg caagcgttcc accatgaaaa cagtattgaa gattggacct aacaatggaa 1800 agaatttttt tgtgtgtcct cttgggaagg aaaaacaatg caattttttc cagtgggcag 1860 aaaatgggcc aggaataaaa attattcctg gatgctaata tctgtagatt ctctggcatt 1920 tagtctcttc aaactgtgta taatgtttgg tcctcctctg tttcatagaa aagtcataga 1980 atatctatga tacattgaaa agttactgca atatttgaga actgttcttt ttttttcttg 2040 tgtgtgccat ctttccattg ttggctacgt cttttctttt gccttgatga acgttctatg 2100 tatttcatcg gatatacagc atattccatt taggatgtgt atttaatgca tttagtaatg 2160 acgataaagt gtttttagta tgcttttagt ctcttgtaac tggggagaag cagtgttttt 2220 tttttaggaa aggattatgc gacacaataa aataagatat tctgtctgta gtg 2273 <210> 451 <211> 1818 <212> DNA <213> Homo sapiens <400> 451 atggtggaag gaccaggctg tactctgaat ggagagaaga ttcgcgcgcg ggtgctcccg 60 ggccaggcgg tgaccggcgt gcggggaagc gctctgcgga gtctgcaggg ccgcgccttg 120 cggctcgcag cctccacggt tgtggtctcc ccgcaggctg ctgcactgaa taatgattcc 180 agccagaatg tcttgagcct gtttaatgga tatgtttaca gtggcgtgga aactttgggg 240 aaggagctct ttatgtactt tggaccaaaa gctttacgga ttcatttcgg aatgaaaggc 300 ttcatcatga ttaatccact tgagtataaa tataaaaatg gagcttctcc tgttttggaa 360 gtgcagctca ccaaagattt gatttgtttc tttgactcat cagtagaact cagaaactca 420 atggaaagcc aacagagaat aagaatgatg aaagaattag atgtatgttc acctgaattt 480 agtttcttga gagcagaaag tgaagttaaa aaacagaaag gccggatgct aggtgatgtg 540 ctaatggatc agaacgtatt gcctggagta gggaacatca tcaaaaatga agctctcttt 600 gacagtggtc tccacccagc tgttaaagtt tgtcaattaa cagatgaaca gatccatcac 660 ctcatgaaaa tgatacgtga tttcagcatt ctcttttaca ggtgccgtaa agcaggactt 720 gctctctcta aacactataa ggtttacaag cgtcctaatt gtggtcagtg ccactgcaga 780 ataactgtgt gccgctttgg ggacaataac agaatgacat atttctgtcc tcactgtcaa 840 aaagaaaatc ctcaacatgt tgacatatgc aagctaccga ctagaaatac tataatcagt 900 tggacatcta gcagggtgga tcatgttatg gactccgtgg ctcggaagtc ggaagagcac 960 tggacctgtg tggtgtgtac tttaatcaat aagccctctt ctaaggcatg tgatgcttgc 1020 ttgacctcaa ggcctattga ttcagtgctc aagagtgaag aaaattctac tgtctttagc 1080 cacttaatga agtacccgtg taatactttt ggaaaacctc atacagaagt caagatcaac 1140 aggaaaactg catttggaac tacaactctt gtcttgactg attttagcaa taaatccagt 1200 actttggaaa gaaaaacaaa gcaaaaccag atactagatg aggagtttca aaactctcct 1260 cctgctagtg tgtgtttgaa tgatatacag cacccctcca agaagacaac aaacgatata 1320 actcaactat ccagcaaagt aaacatatca cctacaatca gttcagaatc taaattattt 1380 agtccagcac ataaaaaacc gaaaacagcc cactactcat caccagagct taaaagctgc 1440 aaccctggat attctaacag tgaacttcaa attaatatga cagatggccc tcgtacctta 1500 aatcctgaca gccctcgctg cagtaaacac aaccgcctct gcatcctccg agttgtgagg 1560 aaggatgggg aaaacaaggg caggcagttt tatgcctgtc ctctacctag agaagcacaa 1620 tgtggatttt ttgaatgggc agatttgtcc ttcccattct gcaaccatgg caagcgttcc 1680 accatgaaaa cagtattgaa gattggacct aacaatggaa agaatttttt tgtgtgtcct 1740 cttgggaagg aaaaacaatg caattttttc cagtgggcag aaaatgggcc aggaataaaa 1800 attattcctg gatgctaa 1818 <210> 452 <211> 2017 <212> DNA <213> Homo sapiens <400> 452 gcgcagcgtt gagttgcaca gcggtattct caccaggccc tgcaatcggt gggccacagt 60 gccggccaca gagatggtgg aaggaccagg ctgtactctg aatggagaga agattcgagc 120 gcgggtgctc ccgggccagg cggtgaccgg cgtgcgggga agcgctctgc ggagtctgca 180 gggccgcgcc ttgcggctcg cagcctccac ggttgtggtc tccccgcagg ctgctgcact 240 gaataatgat tccagccaga atgtcttgag cctgtttaat ggatatgttt acagtggcgt 300 ggaaactttg gggaaggagc tctttatgta ctttggacca aaagctttac ggattcattt 360 cggaatgaaa ggcttcatca tgattaatcc acttgagtat aaatataaaa atggagcttc 420 tcgtgttttg gaagtgcagc tcaccaaaga tttgatttgt ttctttgact catcagtaga 480 actcagaaac tcaatggaaa gccaacagag aataagaatg atgaaagaat tagatgtatg 540 ttcacctgaa tttagtttct tgagagcaga aagtgaagtt aaaaaacaga aaggccggat 600 gctaggtgat gtgctaatgg atcagaacgt attgcctgga gtagggaaca tcatcaaaaa 660 tgaagctctc tttgacagtg gtctccaccc agctgttaaa gtttgtcaat taacagatga 720 acagatccat cacctcatga aaatgatacg tgatttcagc attctctttt acaggtgccg 780 taaagcagga cttgctctct ctaaacacta taaggtttac aagcgtccca attgtggtca 840 gtgccactgc agaataactg tgtgccgctt tggggacaat aacagaatga catatttctg 900 tcctcactgt caaaaagaaa atcctcaaca tgttgacata tgcaagctac cgactagaaa 960 tactataatc agttggacat ctagcagggt ggatcatgtt atggactccg tggctcggaa 1020 gtcggaagag cactggacct gtgtggtgtg tactttaatc aataagccct cttctaaggc 1080 atgtgatgct tgcttgacct caaggcctat tgattcagtg ctcaagagtg aagaaaattc 1140 tactgtcttt agccacttaa tgaagtaccc gtgtaatact tttggaaaac ctcatacaga 1200 agtcaagatc aacaggaaaa ctgcatttgg aactacaact cttgtcttga ctgattttag 1260 caataaatcc agtactttgg aaagaaaaac aaagcaaaac cagatactag atgaggagtt 1320 tcaaaactct cctcctgcta gtgtgtgttt gaatgatata cagcacccct ccaagaagac 1380 aacaaacgat ataactcaac tatccagcaa agtaaacata tcacctacaa tcagttcaga 1440 atctaaatta tttagtccag cacataaaaa accgaaaaca gcccactact catcaccaga 1500 gcttaaaagc tgcaaccctg gatattctaa cagtgaactt caaattaata tgacagatgg 1560 ccctcgtacc ttaaatcctg acagccctcg ctgcagtaaa cacaaccgcc tctgcattct 1620 ccgagttgtg aggaaggatg gggaaaacaa gggcaggcag ttttatgcct gtcctctacc 1680 tagagaagca caatgtggat tttttgaatg ggcagatttg tccttcccat tctgcaacca 1740 tggcaagcgt tccaccatga aaacagtatt gaagattgga cctaacaatg gaaagaattt 1800 ttttgtgtgt cctcttggga aggaaaaaca atgcaatttt ttccagtggg cagaaaatgg 1860 gccaggaata aaaattattc ctggatgcta atatctgtag attctctggc atttagtctc 1920 ttcaaactgt gtataatgtt tggtcctcct ctgtttcata gaaaagtcat agaatatgat 1980 acattgaaaa gttactgcaa aaaaaaaaaa aaaaaaa 2017 <210> 453 <211> 1953 <212> DNA <213> Homo sapiens <400> 453 aggttggcgc gggctgggag gtgttccagc cctttaagat gttgcgcgtg gtgagctgga 60 acatcaatgg gattcggaga cccctgcaag gggtggcaaa tcaggaaccc agcaactgtg 120 ccgccgtggc cgtggggcgc attttggacg agctggatgc ggatatcgtc tgtctccagg 180 aaaccaaagt gaccagggat gcactgacag agcccctggc tatcgttgag ggttataact 240 cctatttcag cttcagccgc aaccgtagcg gctattctgg tgtagccacc ttctgtaagg 300 acaatgctac cccagtggct gctgaagaag gcctgagtgg cctgtttgcc acccagaatg 360 gggatgttgg ttgctatgga aacatggatg agtttaccca agaggaactc cgggctctgg 420 atagtgaggg cagggccctc ctcacacagc ataagatccg cacatgggaa ggtaaggaga 480 agaccttgac cctaatcaac gtgtactgcc cccatgcgga ccctgggagg cctgagcggc 540 tagtctttaa gatgcgcttc tatcgtttgc tgcaaatccg agcagaagcc ctcctggcgg 600 caggcagcca tgtgatcatt ctgggtgacc tgaatacagc ccaccgcccc attgaccact 660 gggatgcagt caacctggaa tgctttgaag aggacccagg gcgcaagtgg atggacagct 720 tgctcagtaa cttggggtgc cagtctgcct ctcatgtagg gcccttcatc gatagctacc 780 gctgcttcca accaaagcag gagggggcct tcacctgctg gtcagcagtc actggcgccc 840 gccatctcaa ctatggctcc cggcttgact atgtgctggg ggacaggacc ctggtcatag 900 acacctttca ggcctctttc ctgctgcctg aggtgatggg ctctgaccac tgccctgtgg 960 gtgcagtctt gagtgtgtcc tctgtgcctg caaaacagtg cccacctctg tgcacccgct 1020 tcctccctga gtttgcaggc acccagctca agatccttcg cttcctagtt cctctcgaac 1080 aaagtcctgt gttggagcag tcgacgctgc agcacaacaa tcaaacccgg gtacagacat 1140 gccaaaacaa agcccaagtg cgctcaacca ggcctcagcc cagtcaggtt ggctctagca 1200 gaggccagaa aaacctgaag agctactttc agccctcccc tagctgtccc caagcctctc 1260 ctgacataga gctgcctagc ctaccactga tgagcgccct catgaccccg aagactccag 1320 aagagaaggc agtggccaaa gtggtgaagg ggcaggccaa gacttcagaa gccaaagatg 1380 agaaggagtt acggacctca ttctggaagt ctgtgctggc ggggcccttg cgcacacccc 1440 tctgtggggg ccacagggag ccatgtgtga tgcgtactgt gaagaagcca ggacccaact 1500 tgggccgccg cttctacatg tgtgccaggc cccggggtcc tcccactgac ccctcctccc 1560 ggtgcaactt cttcctctgg agcaggccca gctgaaccaa tggaggcctg gggacatctg 1620 gcatggtcac ccctgcacat gatctgaggc cagctcccct tccctgagct gcctcctgct 1680 tctccctcaa agtctcctac ccttctcttc ctcttttaag ccctctcttc ctcgctttcc 1740 ttcctaccta gctccttgtt ggtgagcttc ttgtgcctta atcctgtgac ccagcccctt 1800 acaccacttt ccaccttcct gtccgaagta cacggacact agctgcccca ggaagttgtg 1860 tgattttaaa tcacttctgt ctttgctgga aagtgtattt gtgcataaat aaagtctgtg 1920 tatttgtttc aaaaaaaaaa aaaaaaaaaa aaa 1953 <210> 454 <211> 1991 <212> DNA <213> Homo sapiens <400> 454 tggccaactt ctgaacagga agcagttcgc tcgcgcctag gttggcgcgg gctgggaggt 60 gttccagccc tttaagatgt tgcgcgtggt gagctggaac atcaatggga ttcggagacc 120 cctgcaaggg gtggcaaatc aggaacccag caactgtgcc gccgtggccg tggggcgcat 180 tttggacgag ctggatgcgg atatcgtctg tctccaggaa accaaagtga ccagggatgc 240 actgacagag cccctggcta tcgttgaggg ttataactcc tatttcagct tcagccgcaa 300 ccgtagcggc tattctggtg tagccacctt ctgtaaggac aatgctaccc cagtggctgc 360 tgaagaaggc ctgagtggcc tgtttgccac ccagaatggg gatgttggtt gctatggaaa 420 catggatgag tttacccaag aggaactccg ggctctggat agtgagggca gggccctcct 480 cacacagcat aagatccgca catgggaagg taaggagaag accttgaccc taatcaacgt 540 gtactgcccc catgcggacc ctgggaggcc tgagcggcta gtctttaaga tgcgcttcta 600 tcgtttgctg caaatccgag cagaagccct cctggcggca ggcagccatg tgatcattct 660 gggtgacctg aatacagccc accgccccat tgaccactgg gatgcagtca acctggaatg 720 ctttgaagag gacccagggc gcaagtggat ggacagcttg ctcagtaact tggggtgcca 780 gtctgcctct catgtagggc ccttcatcga tagctaccgc tgcttccaac caaagcagga 840 gggggccttc acctgctggt cagcagtcac tggcgcccgc catctcaact atggctcccg 900 gcttgactat gtgctggggg acaggaccct ggtcatagac acctttcagg cctctttcct 960 gctgcctgag gtgatgggct ctgaccactg ccctgtgggt gcagtcttga gtgtgtcctc 1020 tgtgcctgca aaacagtgcc cacctctgtg cacccgcttc ctccctgagt ttgcaggcac 1080 ccagctcaag atccttcgct tcctagttcc tctcgaacaa agtcctgtgt tggagcagtc 1140 gacgctgcag cacaacaatc aaacccgggt acagacatgc caaaacaaag cccaagtgcg 1200 ctcaaccagg cctcagccca gtcaggttgg ctctagcaga ggccagaaaa acctgaagag 1260 ctactttcag ccctccccta gctgtcccca agcctctcct gacatagagc tgcctagcct 1320 accactgatg agcgccctca tgaccccgaa gactccagaa gagaaggcag tggccaaagt 1380 ggtgaagggg caggccaaga cttcagaagc caaagatgag aaggagttac ggacctcatt 1440 ctggaagtct gtgctggcgg ggcccttgcg cacacccctc tgtgggggcc acagggagcc 1500 atgtgtgatg cgtactgtga agaagccagg acccaacttg ggccgccgct tctacatgtg 1560 tgccaggccc cggggtcctc ccactgaccc ctcctcccgg tgcaacttct tcctctggag 1620 caggcccagc tgaaccaatg gaggcctggg gacatctggc atggtcaccc ctgcacatga 1680 tctgaggcca gctccccttc cctgagctgc ctcctgcttc tccctcaaag tctcctaccc 1740 ttctcttcct cttttaagcc ctctcttcct cgctttcctt cctacctagc tccttgttgg 1800 tgagcttctt gtgccttaat cctgtgaccc agccccttac accactttcc accttcctgt 1860 ccgaagtaca cggacactag ctgccccagg aagttgtgtg attttaaatc acttctgtct 1920 ttgctggaaa gtgtatttgt gcataaataa agtctgtgta tttgtttcag ggttgcaaaa 1980 aaaaaaaaaa a 1991 <210> 455 <211> 1956 <212> DNA <213> Homo sapiens <400> 455 ctgaacagga agcagttcgc tcgcgcctag gttggcgcgg gctgggaggt gttccagccc 60 tttaagatgt tgcgcgtggt gagctggaac atcaatggga ttcggagacc cctgcaaggg 120 gtggcaaatc aggaacccag caactgtgcc gccgtggccg tggggcgcat tttggacgag 180 ctggatgcgg atatcgtctg tctccaggaa accaaagtga ccagggatgc actgacagag 240 cccctggcta tcgttgaggg ttataactcc tatttcagct tcagccgcaa ccgtagcggc 300 tattctggtg tagccacctt ctgtaaggac aatgctaccc cagtggctgc tgaagaaggc 360 ctgagtggcc tgtttgccac ccagaatggg gatgttggtt gctatggaaa catggatgag 420 tttacccaag aggaactccg ggctctggat agtgagggca gggccctcct cacacagcat 480 aagatccgca catgggaagg taaggagaag accttgaccc taatcaacgt gtactgcccc 540 catgcggacc ctgggaggcc tgagcggcta gtctttaaga tgcgcttcta tcgtttgctg 600 caaatccgag cagaagccct cctggcggca ggcagccatg tgatcattct gggtgacctg 660 aatacagccc accgccccat tgaccactgg gatgcagtca acctggaatg ctttgaagag 720 gacccagggc gcaagtggat ggacagcttg ctcagtaact tggggtgcca gtctgcctct 780 catgtagggc ccttcatcga tagctaccgc tgcttccaac caaagcagga gggggccttc 840 acctgctggt cagcagtcac tggcgcccgc catctcaact atggctcccg gcttgactat 900 gtgctggggg acaggaccct ggtcatagac acctttcagg cctctttcct gctgcctgag 960 gtgatgggct ctgaccactg ccctgtgggt gcagtcttga gtgtgtcctc tgtgcctgca 1020 aaacagtgcc cacctctgtg cacccgcttc ctccctgagt ttgcaggcac ccagctcaag 1080 atccttcgct tcctagttcc tctcgaacaa agtcctgtgt tggagcagtc gacgctgcag 1140 cacaacaatc aaacccgggt acagacatgc caaaacaaag cccaagtgcg ctcaaccagg 1200 cctcagccca gtcaggttgg ctctagcaga ggccagaaaa acctgaagag ctactttcag 1260 ccctccccta gctgtcccca agcctctcct gacatagagc tgcctagcct accactgatg 1320 agcgccctca tgaccccgaa gactccagaa gagaaggcag tggccaaagt ggtgaagggg 1380 caggccaaga cttcagaagc caaagatgag aaggagttac ggacctcatt ctggaagtct 1440 gtgctggcgg ggcccttgcg cacacccctc tgtgggggcc acagggagcc atgtgtgatg 1500 cgtactgtga agaagccagg acccaacttg ggccgccgct tctacatgtg tgccaggccc 1560 cggggtcctc ccactgaccc ctcctcccgg tgcaacttct tcctctggag caggcccagc 1620 tgaaccaatg gaggcctggg gacatctggc atggtcaccc ctgcacatga tctgaggcca 1680 gctccccttc cctgagctgc ctcctgcttc tccctcaaag tctcctaccc ttctcttcct 1740 cttttaagcc ctctcttcct cgctttcctt cctacctagc tccttgttgg tgagcttctt 1800 gtgccttaat cctgtgaccc agccccttac accactttcc accttcctgt ccgaagtaca 1860 cggacactag ctgccccagg aagttgtgtg attttaaatc acttctgtct ttgctggaaa 1920 gtgtatttgt gcataaataa agtctgtgta tttgtt 1956 <210> 456 <211> 1949 <212> DNA <213> Homo sapiens <400> 456 aggaagcagt tcgctcgcgc ctaggttggc gcgggctggg aggtgttcca gccctttaag 60 atgttgcgcg tggtgagctg gaacatcaat gggattcgga gacccctgca aggggtggca 120 aatcaggaac ccagcaactg tgccgccgtg gccgtggggc gcattttgga cgagctggat 180 gcggatatcg tctgtctcca ggaaaccaaa gtgaccaggg atgcactgac agagcccctg 240 gctatcgttg agggttataa ctcctatttc agcttcagcc gcaaccgtag cggctattct 300 ggtgtagcca ccttctgtaa ggacaatgct accccagtgg ctgctgaaga aggcctgagt 360 ggcctgtttg ccacccagaa tggggatgtt ggttgctatg gaaacatgga tgagtttacc 420 caagaggaac tccgggctct ggatagtgag ggcagggccc tcctcacaca gcataagatc 480 cgcacatggg aaggtaagga gaagaccttg accctaatca acgtgtactg cccccatgcg 540 gaccctggga ggcctgagcg gctagtcttt aagatgcgct tctatcgttt gctgcaaatc 600 cgagcagaag ccctcctggc ggcaggcagc catgtgatca ttctgggtga cctgaataca 660 gcccaccgcc ccattgacca ctgggatgca gtcaacctgg aatgctttga agaggaccca 720 gggcgcaagt ggatggacag cttgctcagt aacttggggt gccagtctgc ctctcatgta 780 gggcccttca tcgatagcta ccgctgcttc caaccaaagc aggagggggc cttcacctgc 840 tggtcagcag tcactggcgc ccgccatctc aactatggct cccggcttga ctatgtgctg 900 ggggacagga ccctggtcat agacaccttt caggcctctt tcctgctgcc tgaggtgatg 960 ggctctgacc actgccctgt gggtgcagtc ttgagtgtgt cctctgtgcc tgcaaaacag 1020 tgcccacctc tgtgcacccg cttcctccct gagtttgcag gcacccagct caagatcctt 1080 cgcttcctag ttcctctcga acaaagtcct gtgttggagc agtcgacgct gcagcacaac 1140 aatcaaaccc gggtacagac atgccaaaac aaagcccaag tgcgctcaac caggcctcag 1200 cccagtcagg ttggctctag cagaggccag aaaaacctga agagctactt tcagccctcc 1260 cctagctgtc cccaagcctc tcctgacata gagctgccta gcctaccact gatgagcgcc 1320 ctcatgaccc cgaagactcc agaagagaag gcagtggcca aagtggtgaa ggggcaggcc 1380 aagacttcag aagccaaaga tgagaaggag ttacggacct cattctggaa gtctgtgctg 1440 gcggggccct tgcgcacacc cctctgtggg ggccacaggg agccatgtgt gatgcgtact 1500 gtgaagaagc caggacccaa cttgggccgc cgcttctaca tgtgtgccag gccccggggt 1560 cctcccactg acccctcctc ccggtgcaac ttcttcctct ggagcaggcc cagctgaacc 1620 aatggaggcc tggggacatc tggcatggtc acccctgcac atgatctgag gccagctccc 1680 cttccctgag ctgcctcctg cttctccctc aaagtctcct acccttctct tcctctttta 1740 agccctctct tcctcgcttt ccttcctacc tagctccttg ttggtgagct tcttgtgcct 1800 taatcctgtg acccagcccc ttacaccact ttccaccttc ctgtccgaag tacacggaca 1860 ctagctgccc caggaagttg tgtgatttta aatcacttct gtctttgctg gaaagtgtat 1920 ttgtgcataa ataaagtctg tgtatttgt 1949 <210> 457 <211> 1938 <212> DNA <213> Homo sapiens <400> 457 gggaggtgtt ccagcccttt aagatgttgc gcgtggtgag ctggaacatc aatgggattc 60 ggagacccct gcaaggggtg gcaaatcagg aacccagcaa ctgtgccgcc gtggccgtgg 120 ggcgcatttt ggacgagctg gatgcggata tcgtctgtct ccaggaaacc aaagtgacca 180 gggatgcact gacagagccc ctggctatcg ttgagggtta taactcctat ttcagcttca 240 gccgcaaccg tagcggctat tctggtgtag ccaccttctg taaggacaat gctaccccag 300 tggctgctga agaaggcctg agtggcctgt ttgccaccca gaatggggat gttggttgct 360 atggaaacat ggatgagttt acccaagagg aactccgggc tctggatagt gagggcaggg 420 ccctcctcac acagcataag atccgcacat gggaaggtaa ggagaagacc ttgaccctaa 480 tcaacgtgta ctgcccccat gcggaccctg ggaggcctga gcggctagtc tttaagatgc 540 gcttctatcg tttgctgcaa atccgagcag aagccctcct ggcggcaggc agccatgtga 600 tcattctggg tgacctgaat acagcccacc gccccattga ccactgggat gcagtcaacc 660 tggaatgctt tgaagaggac ccagggcgca agtggatgga cagcttgctc agtaacttgg 720 ggtgccagtc tgcctctcat gtagggccct tcatcgatag ctaccgctgc ttccaaccaa 780 agcaggaggg ggccttcacc tgctggtcag cagtcactgg cgcccgccat ctcaactatg 840 gctcccggct tgactatgtg ctgggggaca ggaccctggt catagacacc tttcaggcct 900 ctttcctgct gcctgaggtg atgggctctg accactgccc tgtgggtgca gtcttgagtg 960 tgtcctctgt gcctgcaaaa cagtgcccac ctctgtgcac ccgcttcctc cctgagtttg 1020 caggcaccca gctcaagatc cttcgcttcc tagttcctct cgaacaaagt cctgtgttgg 1080 agcagtcgac gctgcagcac aacaatcaaa cccgggtaca gacatgccaa aacaaagccc 1140 aagtgcgctc aaccaggcct cagcccagtc aggttggctc tagcagaggc cagaaaaacc 1200 tgaagagcta ctttcagccc tcccctagct gtccccaagc ctctcctgac atagagctgc 1260 ctagcctacc actgatgagc gccctcatga ccccgaagac tccagaagag aaggcagtgg 1320 ccaaagtggt gaaggggcag gccaagactt cagaagccaa agatgagaag gagttacgga 1380 cctcattctg gaagtctgtg ctggcggggc ccttgcgcac acccctctgt gggggccaca 1440 gggagccatg tgtgatgcgt actgtgaaga agccaggacc caacttgggc cgccgcttct 1500 acatgtgtgc caggccccgg ggtcctccca ctgacccctc ctcccggtgc aacttcttcc 1560 tctggagcag gcccagctga accaatggag gcctggggac atctggcatg gtcacccctg 1620 cacatgatct gaggccagct ccccttccct gagctgcctc ctgcttctcc ctcaaagtct 1680 cctacccttc tcttcctctt ttaagccctc tcttcctcgc tttccttcct acctagctcc 1740 ttgttggtga gcttcttgtg ccttaatcct gtgacccagc cccttacacc actttccacc 1800 ttcctgtccg aagtacacgg acactagctg ccccaggaag ttgtgtgatt ttaaatcact 1860 tctgtctttg ctggaaagtg tatttgtgca taaataaagt ctgtgtattt gtttcagggt 1920 tgcaaaaaaa aaaaaaaa 1938 <210> 458 <211> 1972 <212> DNA <213> Homo sapiens <400> 458 ctgaacagga agcagttcgc tcgcgcctag gttggcgcgg gctgggaggt gttccagccc 60 tttaagatgt tgcgcgtggt gagctggaac atcaatggga ttcggagacc cctgcaaggg 120 gtggcaaatc aggaacccag caactgtgcc gccgtggccg tggggcgcat tttggacgag 180 ctggatgcgg atatcgtctg tctccaggaa accaaagtga ccagggatgc actgacagag 240 cccctggcta tcgttgaggg ttataactcc tatttcagct tcagccgcaa ccgtagcggc 300 tattctggtg tagccacctt ctgtaaggac aatgctaccc cagtggctgc tgaagaaggc 360 ctgagtggcc tgtttgccac ccagaatggg gatgttggtt gctatggaaa catggatgag 420 tttacccaag aggaactccg ggctctggat agtgagggca gggccctcct cacacagcat 480 aagatccgca catgggaagg taaggagaag accttgaccc taatcaacgt gtactgcccc 540 catgcggacc ctgggaggcc tgagcggcta gtctttaaga tgcgcttcta tcgtttgctg 600 caaatccgag cagaagccct cctggcggca ggcagccatg tgatcattct gggtgacctg 660 aatacagccc accgccccat tgaccactgg gatgcagtca acctggaatg ctttgaagag 720 gacccagggc gcaagtggat ggacagcttg ctcagtaact tggggtgcca gtctgcctct 780 catgtagggc ccttcatcga tagctaccgc tgcttccaac caaagcagga gggggccttc 840 acctgctggt cagcagtcac tggcgcccgc catctcaact atggctcccg gcttgactat 900 gtgctggggg acaggaccct ggtcatagac acctttcagg cctctttcct gctgcctgag 960 gtgatgggct ctgaccactg ccctgtgggt gcagtcttga gtgtgtcctc tgtgcctgca 1020 aaacagtgcc cacctctgtg cacccgcttc ctccctgagt ttgcaggcac ccagctcaag 1080 atccttcgct tcctagttcc tctcgaacaa agtcctgtgt tggagcagtc gacgctgcag 1140 cacaacaatc aaacccgggt acagacatgc caaaacaaag cccaagtgcg ctcaaccagg 1200 cctcagccca gtcaggttgg ctctagcaga ggccagaaaa acctgaagag ctactttcag 1260 tcctccccta gctgtcccca agcctctcct gacatagagc tgcctagcct accactgatg 1320 agcgccctca tgaccccgaa gactccagaa gagaaggcag tggccaaagt ggtgaagggg 1380 caggccaaga cttcagaagc caaagatgag aaggagttac ggacctcatt ctggaagtct 1440 gtgctggcgg ggcccttgcg cacacccctc tgtgggggcc acagggagcc atgtgtgatg 1500 cgtactgtga agaagccagg acccaacttg ggccgccgct tctacatgtg tgccaggccc 1560 cggggtcctc ccactgaccc ctcctcccgg tgcaacttct tcctctggag caggcccagc 1620 tgaaccaatg gaggcctggg gacatctggc atggtcaccc ctgcacatga tctgaggcca 1680 gctccccttc cctgagctgc ctcctgcttc tccctcaaag tctcctaccc ttctcttcct 1740 cttttaagcc ctctcttcct cgctttcctt cctacctagc tccttgttgg tgagcttctt 1800 gtgccttaat cctgtgaccc agccccttac accactttcc accttcctgt ccgaagtaca 1860 cggacactag ctgccccagg aagttgtgtg attttaaatc acttctgtct ttgctggaaa 1920 gtgtatttgt gcataaataa agtctgtgta tttgttaaaa aaaaaaaaaa aa 1972 <210> 459 <211> 3859 <212> DNA <213> Homo sapiens <400> 459 aatctatcag ggaacggcgg tggccggtgc ggcgtgttcg gtgcgctctg gccgctcagg 60 ccgtgcggct gggtgagcgc acgcgaggcg gcgaggcggc aagcgtgttt ctaggtcgtg 120 gcgtcgggct tccggagctt tggcggcagc taggggagga tggcggagtc ttcggataag 180 ctctatcgag tcgagtacgc caagagcggg cgcgcctctt gcaagaaatg cagcgagagc 240 atccccaagg actcgctccg gatggccatc atggtgcagt cgcccatgtt tgatggaaaa 300 gtcccacact ggtaccactt ctcctgcttc tggaaggtgg gccactccat ccggcaccct 360 gacgttgagg tggatgggtt ctctgagctt cggtgggatg accagcagaa agtcaagaag 420 acagcggaag ctggaggagt gacaggcaaa ggccaggatg gaattggtag caaggcagag 480 aagactctgg gtgactttgc agcagagtat gccaagtcca acagaagtac gtgcaagggg 540 tgtatggaga agatagaaaa gggccaggtg cgcctgtcca agaagatggt ggacccggag 600 aagccacagc taggcatgat tgaccgctgg taccatccag gctgctttgt caagaacagg 660 gaggagctgg gtttccggcc cgagtacagt gcgagtcagc tcaagggctt cagcctcctt 720 gctacagagg ataaagaagc cctgaagaag cagctcccag gagtcaagag tgaaggaaag 780 agaaaaggcg atgaggtgga tggagtggat gaagtggcga agaagaaatc taaaaaagaa 840 aaagacaagg atagtaagct tgaaaaagcc ctaaaggctc agaacgacct gatctggaac 900 atcaaggacg agctaaagaa agtgtgttca actaatgacc tgaaggagct actcatcttc 960 aacaagcagc aagtgccttc tggggagtcg gcgatcttgg accgagtagc tgatggcatg 1020 gtgttcggtg ccctccttcc ctgcgaggaa tgctcgggtc agctggtctt caagagcgat 1080 gcctattact gcactgggga cgtcactgcc tggaccaagt gtatggtcaa gacacagaca 1140 cccaaccgga aggagtgggt aaccccaaag gaattccgag aaatctctta cctcaagaaa 1200 ttgaaggtta aaaagcagga ccgtatattc cccccagaaa ccagcgcctc cgtggcggcc 1260 acgcctccgc cctccacagc ctcggctcct gctgctgtga actcctctgc ttcagcagat 1320 aagccattat ccaacatgaa gatcctgact ctcgggaagc tgtcccggaa caaggatgaa 1380 gtgaaggcca tgattgagaa actcgggggg aagttgacgg ggacggccaa caaggcttcc 1440 ctgtgcatca gcaccaaaaa ggaggtggaa aagatgaata agaagatgga ggaagtaaag 1500 gaagccaaca tccgagttgt gtctgaggac ttcctccagg acgtctccgc ctccaccaag 1560 agccttcagg agttgttctt agcgcacatc ttgtcccctt ggggggcaga ggtgaaggca 1620 gagcctgttg aagttgtggc cccaagaggg aagtcagggg ctgcgctctc caaaaaaagc 1680 aagggccagg tcaaggagga aggtatcaac aaatctgaaa agagaatgaa attaactctt 1740 aaaggaggag cagctgtgga tcctgattct ggactggaac actctgcgca tgtcctggag 1800 aaaggtggga aggtcttcag tgccaccctt ggcctggtgg acatcgttaa aggaaccaac 1860 tcctactaca agctgcagct tctggaggac gacaaggaaa acaggtattg gatattcagg 1920 tcctggggcc gtgtgggtac ggtgatcggt agcaacaaac tggaacagat gccgtccaag 1980 gaggatgcca ttgagcagtt catgaaatta tatgaagaaa aaaccgggaa cgcttggcac 2040 tccaaaaatt tcacgaagta tcccaaaaag ttttaccccc tggagattga ctatggccag 2100 gatgaagagg cagtgaagaa gctcacagta aatcctggca ccaagtccaa gctccccaag 2160 ccagttcagg acctcatcaa gatgatcttt gatgtggaaa gtatgaagaa agccatggtg 2220 gagtatgaga tcgaccttca gaagatgccc ttggggaagc tgagcaaaag gcagatccag 2280 gccgcatact ccatcctcag tgaggtccag caggcggtgt ctcagggcag cagcgactct 2340 cagatcctgg atctctcaaa tcgcttttac accctgatcc cccacgactt tgggatgaag 2400 aagcctccgc tcctgaacaa tgcagacagt gtgcaggcca aggtggaaat gcttgacaac 2460 ctgctggaca tcgaggtggc ctacagtctg ctcaggggag ggtctgatga tagcagcaag 2520 gatcccatcg atgtcaacta tgagaagctc aaaactgaca ttaaggtggt tgacagagat 2580 tctgaagaag ccgagatcat caggaagtat gttaagaaca ctcatgcaac cacacacagt 2640 gcgtatgact tggaagtcat cgatatcttt aagatagagc gtgaaggcga atgccagcgt 2700 tacaagccct ttaagcagct tcataaccga agattgctgt ggcacgggtc caggaccacc 2760 aactttgctg ggatcctgtc ccagggtctt cggatagccc cgcctgaagc gcccgtgaca 2820 ggctacatgt ttggtaaagg gatctatttc gctgacatgg tctccaagag tgccaactac 2880 taccatacgt ctcagggaga cccaataggc ttaatcctgt tgggagaagt tgcccttgga 2940 aacatgtatg aactgaagca cgcttcacat atcagcaggt tacccaaggg caagcacagt 3000 gtcaaaggtt tgggcaaaac tacccctgat ccttcagcta acattagtct ggatggtgta 3060 gacgttcctc ttgggaccgg gatttcatct ggtgtgatag acacctctct actatataac 3120 gagtacattg tctatgatat tgctcaggta aatctgaagt atctgctgaa actgaaattc 3180 aattttaaga cctccctgtg gtaattggga gaggtagccg agtcacaccc ggtggctgtg 3240 gtatgaattc acccgaagcg cttctgcacc aactcacctg gccgctaagt tgctgatggg 3300 tagtacctgt actaaaccac ctcagaaagg attttacaga aacgtgttaa aggttttctc 3360 taacttctca agtcccttgt tttgtgttgt gtctgtgggg aggggttgtt ttggggttgt 3420 ttttgttttt tcttgccagg tagataaaac tgacatagag aaaaggctgg agagagattc 3480 tgttgcatag actagtccta tggaaaaaac caaagcttcg ttagaatgtc tgccttactg 3540 gtttccccag ggaaggaaaa atacacttcc accctttttt ctaagtgttc gtctttagtt 3600 ttgattttgg aaagatgtta agcatttatt tttagttaaa ataaaaacta atttcatact 3660 atttagattt tcttttttat cttgcactta ttgtcccctt tttagttttt tttgtttgcc 3720 tcttgtggtg aggggtgtgg gaagaccaaa ggaaggaacg ctaacaattt ctcatactta 3780 gaaacaaaaa gagctttcct tctccaggaa tactgaacat gggagctctt gaaatatgta 3840 gtattaaaag ttgcatttg 3859 <210> 460 <211> 3660 <212> DNA <213> Homo sapiens <400> 460 aatctatcag ggaacggcgg tggccggtgc ggcgtgttcg gtgcgctctg gccgctcagg 60 ccgtgcggct gggtgagcgc acgcgaggcg gcgaggcggc aagcgtgttt ctaggtcgtg 120 gcgtcgggct tccggagctt tggcggcagc taggggagga tggcggagtc ttcggataag 180 ctctatcgag tcgagtacgc caagagcggg cgcgcctctt gcaagaaatg cagcgagagc 240 atccccaagg actcgctccg gatggccatc atggtgcagt cgcccatgtt tgatggaaaa 300 gtcccacact ggtaccactt ctcctgcttc tggaaggtgg gccactccat ccggcaccct 360 gacgttgagg tggatgggtt ctctgagctt cggtgggatg accagcagaa agtcaagaag 420 acagcggaag ctggaggagt gacaggcaaa ggccaggatg gaattggtag caaggcagag 480 aagactctgg gtgactttgc agcagagtat gccaagtcca acagaagtac gtgcaagggg 540 tgtatggaga agatagaaaa gggccaggtg cgcctgtcca agaagatggt ggacccggag 600 aagccacagc taggcatgat tgaccgctgg taccatccag gctgctttgt caagaacagg 660 gaggagctgg gtttccggcc cgagtacagt gcgagtcagc tcaagggctt cagcctcctt 720 gctacagagg ataaagaagc cctgaagaag cagctcccag gagtcaagag tgaaggaaag 780 agaaaaggcg atgaggtgga tggagtggat gaagtggcga agaagaaatc taaaaaagaa 840 aaagacaagg atagtaagct tgaaaaagcc ctaaaggctc agaacgacct gatctggaac 900 atcaaggacg agctaaagaa agtgtgttca actaatgacc tgaaggagct actcatcttc 960 aacaagcagc aagtgccttc tggggagtcg gcgatcttgg accgagtagc tgatggcatg 1020 gtgttcggtg ccctccttcc ctgcgaggaa tgctcgggtc agctggtctt caagagcgat 1080 gcctattact gcactgggga cgtcactgcc tggaccaagt gtatggtcaa gacacagaca 1140 cccaaccgga aggagtgggt aaccccaaag gaattccgag aaatctctta cctcaagaaa 1200 ttgaaggtta aaaagcagga ccgtatattc cccccagaaa ccagcgcctc cgtggcggcc 1260 acgcctccgc cctccacagc ctcggctcct gctgctgtga actcctctgc ttcagcagat 1320 aagccattat ccaacatgaa gatcctgact ctcgggaagc tgtcccggaa caaggatgaa 1380 gtgaaggcca tgattgagaa actcgggggg aagttgacgg ggacggccaa caaggcttcc 1440 ctgtgcatca gcaccaaaaa ggaggtggaa aagatgaata agaagatgga ggaagtaaag 1500 gaagccaaca tccgagttgt gtctgaggac ttcctccagg acgtctccgc ctccaccaag 1560 agccttcagg agttgttctt agcgcacatc ttgtcccctt ggggggcaga ggtgaaggca 1620 gagcctgttg aagttgtggc cccaagaggg aagtcagggg ctgcgctctc caaaaaaagc 1680 aagggccagg tcaaggagga aggtatcaac aaatctgaaa agagaatgaa attaactctt 1740 aaaggaggag cagctgtgga tcctgattct ggactggaac actctgcgca tgtcctggag 1800 aaaggtggga aggtcttcag tgccaccctt ggcctggtgg acatcgttaa aggaaccaac 1860 tcctactaca agctgcagct tctggaggac gacaaggaaa acaggtattg gatattcagg 1920 tcctggggcc gtgtgggtac ggtgatcggt agcaacaaac tggaacagat gccgtccaag 1980 gaggatgcca ttgagcagtt catgaaatta tatgaagaaa aaaccgggaa cgcttggcac 2040 tccaaaaatt tcacgaagta tcccaaaaag ttttaccccc tggagattga ctatggccag 2100 gatgaagagg cagtgaagaa gctcacagta aatcctggca ccaagtccaa gctccccaag 2160 ccagttcagg acctcatcaa gatgatcttt gatgtggaaa gtatgaagaa agccatggtg 2220 gagtatgaga tcgaccttca gaagatgccc ttggggaagc tgagcaaaag gcagatccag 2280 gccgcatact ccatcctcag tgaggtccag caggcggtgt ctcagggcag cagcgactct 2340 cagatcctgg atctctcaaa tcgcttttac accctgatcc cccacgactt tgggatgaag 2400 aagcctccgc tcctgaacaa tgcagacagt gtgcaggcca aggtggaaat gcttgacaac 2460 ctgctggaca tcgaggtggc ctacagtctg ctcaggggag ggtctgatga tagcagcaag 2520 gatcccatcg atgtcaacta tgagaagctc aaaactgaca ttaaggtggt tgacagagat 2580 tctgaagaag ccgagatcat caggaagtat gttaagaaca ctcatgcaac cacacacagt 2640 gcgtatgact tggaagtcat cgatatcttt aagatagagc gtgaaggcga atgccagcgt 2700 tacaagccct ttaagcagct tcataaccga agattgctgt ggcacgggtc caggaccacc 2760 aactttgctg ggatcctgtc ccagggtctt cggatagccc cgcctgaagc gcccgtgaca 2820 ggctacatgt ttggtaaagg gatctatttc gctgacatgg tctccaagag tgccaactac 2880 taccatacgt ctcagggaga cccaataggc ttaatcctgt tgggagaagt tgcccttgga 2940 aacatgtatg aactgaagca cgcttcacat atcagcaggt tacccaaggg caagcacagt 3000 gtcaaaggtt tgggcaaaac tacccctgat ccttcagcta acattagtct ggatggtgta 3060 gacgttcctc ttgggaccgg gatttcatct ggtgtgatag acacctctct actatataac 3120 gagtacattg tctatgatat tgctcaggta aatctgaagt atctgctgaa actgaaattc 3180 aattttaaga cctccctgtg gtaattggga gaggtagccg agtcacaccc ggtggctgtg 3240 gtatgaattc acccgaagcg cttctgcacc aactcacctg gccgctaagt tgctgatggg 3300 tagtacctgt actaaaccac ctcagaaagg attttacaga aacgtgttaa aggttttctc 3360 taacttctca agtcccttgt tttgtgttgt gtctgtgggg aggggttgtt ttggggttgt 3420 ttttgttttt tcttgccagg tagataaaac tgacatagag aaaaggctgg agagagattc 3480 tgttgcatag actagtccta tggaaaaaac caaagcttcg ttagaatgtc tgccttactg 3540 gtttccccag ggaaggaaaa atacacttcc accctttttt ctaagtgttc gtctttagtt 3600 ttgattttgg aaagatgtta agcatttatt tttagttaaa ataaaaacta atttcatact 3660 <210> 461 <211> 3640 <212> DNA <213> Homo sapiens <400> 461 aatctatcag gaacgcgtgc gtcgcgtgtt cgtgcggctc tggccgctca gctcggctgg 60 gtgagcgcac gcgagcgcag cggcagcgtg tttctaggtc gtgcgtcggg cttccggagc 120 tttgcggcag ctagggagga tggcggagtc ttcggataag ctctatcgag tcgagtacgc 180 caagagcggg cgcgcctctt gcaagaaatg cagcgagagc atccccaagg actcgctccg 240 gatggccatc atggtgcagt cgcccatgtt tgatggaaaa gtcccacact ggtaccactt 300 ctcctgcttc tggaaggtgg gccactccat ccggcaccct gacgttcagg tggatgggtt 360 ctctgagctt cggtgggatg accagcagaa agtcaagaag acagcggaag ctggaggagt 420 gacaggcaaa ggccaggatg gaattggtag caaggcagag aagactctgg gtgactttgc 480 agcagagtat gccaagtcca acagaagtac gtgcaagggg tgtatggaga agatagaaaa 540 gggccaggtg cgcctgtcca agaagatggt ggacccggag aagccacagc taggcatgat 600 tgaccgctgg taccatccag gctgctttgt caagaacagg gaggagctgg gtttccggcc 660 cgagtacagt gcgagtcagc tcaagggctt cagcctcctt gctacagagg ataaagaagc 720 cctgaagaag cagctcccag gagtcaagag tgaaggaaag agaaaaggcg atgaggtgga 780 tggagtggat gaagtggcga agaagaaatc taaaaaagaa aaagacaagg atagtaagct 840 tgaaaaagcc ctaaaggctc agaacgacct gatctggaac atcaaggacg agctaaagaa 900 agtgtgttca actaatgacc tgaaggagct actcatcttc aacaagcagc aagtgccttc 960 tggggagtcg gcgatcttgg accgagtagc tgatggcatg gtgttcggtg ccctccttcc 1020 ctgcgaggaa tgctcgggtc agctggtctt caagagcgat gcctattact gcactgggga 1080 cgtcactgcc tggaccaagt gtatggtcaa gacacagaca cccaaccgga aggagtgggt 1140 aaccccaaag gaattccgag aaatctctta cctcaagaaa ttgaaggtta aaaagcagga 1200 ccgtatattc cccccagaaa ccagcgcctc cgtggcggcc acgcctccgc cctccacagc 1260 ctcggctcct gctgctgtga actcctctgc ttcagcagat aagccattat ccaacatgaa 1320 gatcctgact ctcgggaagc tgtcccggaa caaggatgaa gtgaaggcca tgattgagaa 1380 actcgggggg aagttgacgg ggacggccaa caaggcttcc ctgtgcatca gcaccaaaaa 1440 ggaggtggaa aagatgaata agaagatgga ggaagtaaag gaagccaaca tccgagttgt 1500 gtctgaggac ttcctccagg acgtctccgc ctccaccaag agccttcagg agttgttctt 1560 agcgcacatc ttgtcccctt ggggggcaga ggtgaaggca gagcctgttg aagttgtggc 1620 cccaagaggg aagtcagggg ctgcgctctc caaaaaaagc aagggccagg tcaaggagga 1680 aggtatcaac aaatctgaaa agagaatgaa attaactctt aaaggaggag cagctgtgga 1740 tcctgattct ggactggaac actctgcgca tgtcctggag aaaggtggga aggtcttcag 1800 tgccaccctt ggcctggtgg acatcgttaa aggaaccaac tcctactaca agctgcagct 1860 tctggaggac gacaaggaaa acaggtattg gatattcagg tcctggggcc gtgtgggtac 1920 ggtgatcggt agcaacaaac tggaacagat gccgtccaag gaggatgcca ttgagcactt 1980 catgaaatta tatgaagaaa aaaccgggaa cgcttggcac tccaaaaatt tcacgaagta 2040 tcccaaaaag ttctaccccc tggagattga ctatggccag gatgaagagg cagtgaagaa 2100 gctgacagta aatcctggca ccaagtccaa gctccccaag ccagttcagg acctcatcaa 2160 gatgatcttt gatgtggaaa gtatgaagaa agccatggtg gagtatgaga tcgaccttca 2220 gaagatgccc ttggggaagc tgagcaaaag gcagatccag gccgcatact ccatcctcag 2280 tgaggtccag caggcggtgt ctcagggcag cagcgactct cagatcctgg atctctcaaa 2340 tcgcttttac accctgatcc cccacgactt tgggatgaag aagcctccgc tcctgaacaa 2400 tgcagacagt gtgcaggcca aggtggaaat gcttgacaac ctgctggaca tcgaggtggc 2460 ctacagtctg ctcaggggag ggtctgatga tagcagcaag gatcccatcg atgtcaacta 2520 tgagaagctc aaaactgaca ttaaggtggt tgacagagat tctgaagaag ccgagatcat 2580 caggaagtat gttaagaaca ctcatgcaac cacacacaat gcgtatgact tggaagtcat 2640 cgatatcttt aagatagagc gtgaaggcga atgccagcgt tacaagccct ttaagcagct 2700 tcataaccga agattgctgt ggcacgggtc caggaccacc aactttgctg ggatcctgtc 2760 ccagggtctt cggatagccc cgcctgaagc gcccgtgaca ggctacatgt ttggtaaagg 2820 gatctatttc gctgacatgg tctccaagag tgccaactac tgccatacgt ctcagggaga 2880 cccaataggc ttaatcctgt tgggagaagt tgcccttgga aacatgtatg aactgaagca 2940 cgcttcacat atcagcaagt tacccaaggg caagcacagt gtcaaaggtt tgggcaaaac 3000 tacccctgat ccttcagcta acattagtct ggatggtgta gacgttcctc ttgggaccgg 3060 gatttcatct ggtgtgaatg acacctctct actatataac gagtacattg tctatgatat 3120 tgctcaggta aatctgaagt atctgctgaa actgaaattc aattttaaga cctccctgtg 3180 gtaattggga gaggtagccg agtcacaccc ggtggctctg gtatgaattc acccgaagcg 3240 cttctgcacc aactcacctg gccgctaagt tgctgatggg tagtacctgt actaaaccac 3300 ctcagaaagg attttacaga aacgtgttaa aggttttctc taacttctca agtcccttgt 3360 tttgtgttgt gtctgtgggg aggggttgtt ttggggttgt ttttgttttt tcttgccagg 3420 tagataaaac tgacatagag aaaaggctgg agagagattc tgttgcatag actagtccta 3480 tggaaaaaac caagcttcgt tagaatgtct gccttactgg tttccccagg gaaggaaaaa 3540 tacacttcca cccttttttc taagtgttcg tctttagttt tgattttgga aagatgttaa 3600 gcatttattt ttagttaaaa ataaaaacta atttcatact 3640 <210> 462 <211> 3795 <212> DNA <213> Homo sapiens <400> 462 tgcggctggg tgagcgcacg cgaggcggcg aggcggcagc gtgtttctag gtcgtggcgt 60 cgggcttccg gagctttggc ggcagctagg ggaggatggc ggagtcttcg gataagctct 120 atcgagtcga gtacgccaag agcgagcgcg cctcttgcaa gaaatgcagc gagagcatcc 180 ccaaggactc gctccggatg gccatcatgg tgcagtcgcc catgtttgat ggaaaagtcc 240 cacactggta ccacttctcc tgcttctgga aggtgggcca ctccatccgg caccctgacg 300 ttgaggtgga tgggttctct gagcttcggt gggatgacca gcagaaagtc aagaagacag 360 cggaagctgg aggagtgaca ggcaaaggcc aggatggaat tggtagcaag gcagagaaga 420 ctctgggtga ctttgcagca gagtatgcca agtccaacag aagtacgtgc aaggggtgta 480 tggagaagat agaaaagggc caggtgcgcc tgtccaagaa gatggtggac ccggagaagc 540 cacagctagg catgattgac cgctggtacc atccaggctg ctttgtcaag aacagggagg 600 agctgggttt ccggcccgag tacagtgcga gtcagctcaa gggcttcagc ctccttgcta 660 cagaggataa agaagccctg aagaagcagc tcccaggagt caagagtgaa ggaaagagaa 720 aaggcgataa ggtggatgga gtggatgaag tggcgaagaa gaaatctaaa aaagaaaaag 780 acaaggatag taagcttgaa aaagccctaa aggctcagaa cgacctgatc tggaacatca 840 aggacgagct aaagaaagtg tgttcaacta atgacctgaa ggagctactc atcttcaaca 900 agcagcaagt gccttctggg gagtcggcga tcttggaccg agtagctgat ggcatggtgt 960 tcggtgccct ccttccctgc gaggaatgct cgggtcagct ggtcttcaag agcgatgcct 1020 attactgcac tggggacgtc actgcctgga ccaagtgtat ggtcaagaca cagacaccca 1080 accggaagga gtgggtaacc ccaaaggaat tccgagaaat ctcttacctc aagaaattga 1140 aggttaaaaa gcaggaccgt atattccccc cagaaaccag cgcctccgtg gcggccacgc 1200 ctccgccctc cacagcctcg gctcctgctg ctgtgaactc ctctgcttca gcagataagc 1260 cattatccaa catgaagatc ctgactctcg ggaagctgtc ccggaacaag gatgaagtga 1320 aggccatgat tgagaaactc ggggggaagt taacggggac ggccaacaag gcttccctgt 1380 gcatcagcac caaaaaggag gtggaaaaga tgaataagaa gatggaggaa gtaaaggaag 1440 ccaacatccg agttgtgtct gaggacttcc tccaggacgt ctccgcctcc accaagagcc 1500 ttcaggagtt gttcttagcg cacatcttgt ccccttgggg ggcagaggtg aaggcagagc 1560 ctgttgaagt tgtggcccca agagggaagt caggggctgc gctctccaaa aaaagcaagg 1620 gccaggtcaa ggaggaaggt atcaacaaat ctgaaaagag aatgaaatta actcttaaag 1680 gaggagcagc tgtggatcct gattctggac tggaacactc tgcgcatgtc ctggagaaag 1740 gtgggaaggt cttcagtgcc acccttggcc tggtggacat cgttaaagga accaactcct 1800 actacaagct gcagcttctg gaggacgaca aggaaaacag gtattggata ttcaggtcct 1860 ggggccgtgt gggtacggtg atcggtagca acaaactgga acagatgccg tccaaggagg 1920 atgccattga gcacttcatg aaattatatg aagaaaaaac cgggaacgct tggcactcca 1980 aaaatttcac gaagtatccc aaaaagttct accccctgga gattgactat ggccaggatg 2040 aagaggcagt gaagaagctg acagtaaatc ctggcaccaa gtccaagctc cccaagccag 2100 ttcaggacct catcaagatg atctttgatg tggaaagtat gaagaaagcc atggtggagt 2160 atgagatcga ccttcagaag atgcccttgg ggaagctgag caaaaggcag atccaggccg 2220 catactccat cctcagtgag gtccagcagg cggtgtctca gggcagcagc gactctcaga 2280 tcctggatct ctcaaatcgc ttttacaccc tgatccccca cgactttggg atgaagaagc 2340 ctccgctcct gaacaatgca gacagtgtgc aggccaaggt ggaaatgctt gacaacctgc 2400 tggacatcga ggtggcctac agtctgctca ggggagggtc tgatgatagc agcaaggatc 2460 ccatcgatgt caactatgag aagctcaaaa ctgacattaa ggtggttgac agagattctg 2520 aagaagccga gatcatcagg aagtatgtta agaacactca tgcaaccaca cacaatgcgt 2580 atgacttgga agtcatcgat atctttaaga tagagcgtga aggcgaatgc cagcgttaca 2640 agccctttaa gcagcttcat aaccgaagat tgctgtggca cgggtccagg accaccaact 2700 ttgctgggat cctgtcccag ggtcttcgga tagccccgcc tgaagcgccc gtgacaggct 2760 acatgtttgg taaagggatc tatttcgctg acatggtctc caagagtgcc aactactgcc 2820 atacgtctca gggagaccca ataggcttaa tcctgttggg agaagttgcc cttggaaaca 2880 tgtatgaact gaagcacgct tcacatatca gcaagttacc caagggcaag cacagtgtca 2940 aaggtttggg caaaactacc cctgatcctt cagctaacat tagtctggat ggtgtagacg 3000 ttcctcttgg gaccgggatt tcatctggtg tgaatgacac ctctctacta tataacgagt 3060 acattgtcta tgatattgct caggtaaatc tgaagtatct gctgaaactg aaattcaatt 3120 ttaagacctc cctgtggtaa ttgggagagg tagccgagtc acacccggtg gctctggtat 3180 gaattcaccc gaagcgcttc tgcaccaact cacctggccg ctaagttgct gatgggtagt 3240 acctgtacta aaccacctca gaaaggattt tacagaaacg tgttaaaggt tttctctaac 3300 ttctcaagtc ccttgttttg tgttgtgtct gtggggaggg gttgttttgg ggttgttttt 3360 gttttttctt gccaggtaga taaaactgac atagagaaaa ggctggagag agattctgtt 3420 gcatagacta gtcctatgga aaaaaccaag cttcgttaga atgtctgcct tactggtttc 3480 cccagggaag gaaaaataca cttccaccct tttttctaag tgttcgtctt tagttttgat 3540 tttggaaaga tgttaagcat ttatttttag ttaaaaataa aaactaattt catactattt 3600 agattttctt ttttatcttg cacttattgt ccccttttta gttttttttg tttgcctctt 3660 gtggtgaggg gtgtgggaag accaaaggaa ggaacgctaa caatttctca tacttagaaa 3720 caaaaagagc tttccttctc caggaatact gaacatggga gctcttgaaa tatgtagtat 3780 taaaagttgc atttg 3795 <210> 463 <211> 3677 <212> DNA <213> Homo sapiens <400> 463 cggtggccgg tgcggcgtgt tcggtggcgg ctctggccgc tcaggcgcct gcggctgggt 60 gagcgcacgc gaggcggcga ggcggcagcg tgtttctagg tcgtggcgtc gggcttccgg 120 agctttgccg gcagctaggg gaggatggcg gagtcttcgg ataagctcta tcgagtcgag 180 tacgccaaga gcgggcgcgc ctcttgcaag aaatgcagcg agagcatccc caaggactcg 240 ctccggatgg ccatcatggt gcagtcgccc atgtttgatg gaaaagtccc acactggtac 300 cacttctcct gcttctggaa ggtgggccac tccatccggc accctgacgt tgaggtggat 360 gggttctctg agcttcggtg ggatgatcag cagaaagtca agaagacagc ggaagctgga 420 ggagtgacag gcaaaggcca ggatggaatt ggtagcaagg cagagaagac tctgggtgac 480 tttgcagcag agtatgccaa gtccaacaga agtacgtgca aggggtgtat ggagaagata 540 gaaaagggcc aggtgcgcct gtccaagaag atggtggacc cggagaagcc acagctaggc 600 atgattgacc gctggtacca tccaggctgc tttgtcaaga acagggagga gctgggtttc 660 cggcccgagt acagtgcgag tcagctcaag ggcttcagcc tccttgctac agaggataaa 720 gaagccctga agaagcagct cccaggagtc aagagtgaag gaaagagaaa aggcgatgag 780 gtggatggag tggatgaagt ggcgaagaag aaatctaaaa aagaaaaaga caaggatagt 840 aagcttgaaa aagccctaaa ggctcagaac gacctgatct ggaacatcaa ggacgagcta 900 aagaaagtgt gttcaactaa tgacctgaag gagctactca tcttcaacaa gcagcaagtg 960 ccttctgggg agtcggcgat cttggaccga gtagccgatg gcatggtgtt cggtgccctc 1020 cttccctgcg aggaatgctc gggtcagctg gtcttcaaga gcgatgccta ttactgcact 1080 ggggacgtca ctgcctggac caagtgtatg gtcaagacac agacacccaa ccggaaggag 1140 tgggtaaccc caaaggaatt ccgagaaatc tcttacctca agaaattgaa ggttaaaaaa 1200 caggaccgta tattcccccc agaaaccagc gcctccgtgg cggccacgcc tccgccctcc 1260 acagcctcgg ctcctgctgc tgtgaactcc tctgcttcag cagataagcc attatccaac 1320 atgaagatcc tgactctcgg gaagctgtcc cggaacaagg atgaagtgaa ggccatgatt 1380 gagaaactcg gggggaagtt gacggggacg gccaacaagg cttccctgtg catcagcacc 1440 aaaaaggagg tggaaaagat gaataagaag atggaggaag taaaggaagc caacatccga 1500 gttgtgtctg aggacttcct ccaggacgtc tccgcctcca ccaagagcct tcaggagttg 1560 ttcttagcgc acatcttgtc cccttggggg gcagaggtga aggcagagcc tgttgaagtt 1620 gtggccccaa gagggaagtc aggggctgcg ctctccaaaa aaagcaaggg ccaggtcaag 1680 gaggaaggta tcaacaaatc tgaaaagaga atgaaattaa ctcttaaagg aggagcagct 1740 gtggatcctg attctggact ggaacactct gcgcatgtcc tggagaaagg tgggaaggtc 1800 ttcagtgcca cccttggcct ggtggacatc gttaaaggaa ccaactccta ctacaagctg 1860 cagcttctgg aggacgacaa ggaaaacagg tattggatat tcaggtcctg gggccgtgtg 1920 ggtacggtga tcggtagcaa caaactggaa cagatgccgt ccaaggagga tgccattgag 1980 cacttcatga aattatatga agaaaaaacc gggaacgctt ggcactccaa aaatttcacg 2040 aagtatccca aaaagttcta ccccctggag attgactatg gccaggatga agaggcagtg 2100 aagaagctga cagtaaatcc tggcaccaag tccaagctcc ccaagccagt tcaggacctc 2160 atcaagatga tctttgatgt ggaaagtatg aagaaagcca tggtggagta tgagatcgac 2220 cttcagaaga tgcccttggg gaagctgagc aaaaggcaga tccaggccgc atactccatc 2280 ctcagtgagg tccagcaggc ggtgtctcag ggcagcagcg actctcagat cctggatctc 2340 tcaaatcgct tttacaccct gatcccccac gactttggga tgaagaagcc tccgctcctg 2400 aacaatgcag acagtgtgca ggccaaggcg gaaatgcttg acaacctgct ggacatcgag 2460 gtggcctaca gtctgctcag gggagggtct gatgatagca gcaaggatcc catcgatgtc 2520 aactatgaga agctcaaaac tgacattaag gtggttgaca gagattctga agaagccgag 2580 atcatcagga agtatgttaa gaacactcat gcaaccacac acaatgcgta tgacttggaa 2640 gtcatcgata tctttaagat agagcgtgaa ggcgaatgcc agcgttacaa gccctttaag 2700 cagcttcata accgaagatt gctgtggcac gggtccagga ccaccaactt tgctgggatc 2760 ctgtcccagg gtcttcggat agccccgcct gaagcgcccg tgacaggcta catgtttggt 2820 aaagggatct atttcgctga catggtctcc aagagtgcca actactgcca tacgtctcag 2880 ggagacccaa taggcttaat cctgttggga gaagttgccc ttggaaacat gtatgaactg 2940 aagcacgctt cacatatcag caagttaccc aagggcaagc acagtgtcaa aggtttgggc 3000 aaaactaccc ctgatccttc agctaacatt agtctggatg gtgtagacgt tcctcttggg 3060 accgggattt catctggtgt gaatgacacc tctctactat ataacgagta cattgtctat 3120 gatattgctc aggtaaatct gaagtatctg ctgaaactga aattcaattt taagacctcc 3180 ctgtggtaat tgggagaggt agccgagtca cacccggtgg ctctggtatg aattcacccg 3240 aagcgcttct gcaccaactc acctggccgc taagttgctg atgggtagta cctgtactaa 3300 accacctcag aaaggatttt acagaaacgt gttaaaggtt ttctctaact tctcaagtcc 3360 cttgttttgt gttgtgtctg tggggagggg ttgttttggg gttgtttttg ttttttcttg 3420 ccaggtagat aaaactgaca tagagaaaag gctggagaga gattctgttg catagactag 3480 tcctatggaa aaaaccaagc ttcgttagaa tgtctgcctt actggtttcc ccagggaagg 3540 aaaaatacac ttccaccctt ttttctaagt gttcgtcttt agttttgatt ttggaaagat 3600 gttaagcatt tatttttagt taaaaataaa aactaatttc atactattta aaaaaaaaaa 3660 aaaaaaaaaa aaaaaaa 3677 <210> 464 <211> 3730 <212> DNA <213> Homo sapiens <400> 464 aattaaagac gaactattga gctgggtact cgggagcctg cggccaggtg agtgtgggcg 60 gggcggcaag gcggaagctc caggcgcagg cggcggaagc gcgtgtctcc aggtcgtcgc 120 gtcgggctcc tgggatttgg cggcaactgt gggaggatgg cagagtcctc ggataagctc 180 tactgagtgg agtacaccaa gagcgggcgc acctcttgca agaaatgcag cgagagcatc 240 cccaaggact cgctgcggat ggccatcatg gtgcaatagt ccatgtttga tggagaagtc 300 ccacactggt accacttctc ctgcttgcgg aaggtgggcc actccatgcg gcaccctgac 360 gttgaggtgg atggattctc tgagctttgg tgggatgacc agcagaaagt caagaagaca 420 gctgacgctg gaggagtgac gggcaaaggc cagaatggaa ttggtagcaa ggcagagaag 480 acgctgggtg actttgcagc agagtaggcc aagtccagca gaagcaagtg caagaggtgt 540 tatggagaag atagaaaagg gccagatgcg cctatccaag aagatgctgg accctgagaa 600 gcctcagcta ggcatgattg acccctggta ccacccaggc tgctttgtca agaacaggga 660 ggagctgggt ttccagcctg agtacagtgc gagtcagctc aagggcttca gcctcctcgc 720 tgcagaggat aaagaaaccc tgaagaagca gctcccagga gtcaagagtg aaggaaagag 780 agaaggcgat gaggtggatg gagtggatga agtggccaag aagaaatcta aaaaagaaaa 840 agacgaggat ggtaagcttg aaaaggccct aaaggcccag aacgacctga tctggaacat 900 caaggacgag ctaatgaaag tgtgctctat taatgacctg aaggagatgc tcatcttcaa 960 caggcagcag gtgccttccg gggagtcggc gatcttggac cgagtagctg acagcatgac 1020 gttcggtgcc ctccttccct gtgaggaatg ctcaggtcag ctggtcttca agagcgacac 1080 ttattactgc accggggacg tcacggcctg gaccaagtgt atggtcaaga catggacacc 1140 caaccagaag gaataggtga tcccaccgag aaatctctta actcaagaaa tttaaggtta 1200 aaaagcagga ccgtatattc cccccagaaa ccagtgaccc agtggcggcc atgcccccac 1260 cctccacagc ctccgagcct gctgccatga acgcctctgc tccagcagat aagccgttat 1320 ccaacatgaa gatccttact cttgggaagc tctcccggaa caaggatgaa gtgaaggcca 1380 cgattgagaa actcggggga aagttgatgg ggacggccaa caaggcttct ccgtgcatca 1440 gcactaaaga ggaggtggaa aagaagaaga agaagatgga ggaagtgaaa gaagccaaca 1500 tctgagctgt gtctgaggac ttcctccagg acttctctgc ctccaccaag gggctccagg 1560 agttgttctc agcgcacatc ttgtccccct ggggggcaga agtgaaggca gagcctgttg 1620 aagtcgtagc cccaagaggg aagtcaggag ctgtgctctc caaaaaaagc aagggccagg 1680 tcaaggagga aggtatcaac aaatctgaaa agagaatgaa attaactctt aaaggaggag 1740 cagctgtgga tcctgactct ggtctggaac actctgcaca tgttctggag aaaggtggga 1800 aggtcttcag tgccaccctc agcctggtgg acgtcgttaa aggaaccaac tcctattaca 1860 agctgaagtt gctgaaggat gacaaggaaa gcaggcattg gatattcaag tcctgggacc 1920 gtgtgggcac ggtgatcggt agcaacaaac tggaacagat gctgtccaag gaggacacca 1980 ctgaacactt catgaaatta tatgaagaaa aactaggaat gcttggcact ccaaaaattc 2040 acaaagtatc ccaaaaagtt ctaccccctg gagattgact acggccagga caaagaggcg 2100 gtgaagaagc cgacagtaaa tcctggcacc aagtccatgc tccccaagcc agttcaggac 2160 ctcatcaaga tgatctttga tgtggaaagt atgagcaaag ccatggtggg gtgtgagatc 2220 gaccttcaga tgcccttggg gaagctgagc aaaaggcaaa tccaggccgc gtactccatc 2280 ctcaggtcca gcaggtggtg tcccagggca gcagcgactc tcagatcctg gatttctcaa 2340 atcgctttta catcctgatc ccccacgact ttgggatgaa ggatcctctg ctcctgaaca 2400 atgcagacag tgtgcaggcc aaggtagaaa tgctggacaa cctgctggac attgaggtag 2460 cctacggtct gctcagggga gggtctcacg atagcaggaa ggactccatc gatgtcaact 2520 atgagaagct caaaactgac attaaggtgg ttgacagaga ttctgaagaa gctgagatca 2580 tcaggaagta tgttaagaac actcatgcaa ccaaccacac acgatgcata tgacttggaa 2640 gtcattgata gctttaagat agagtgtgaa gaggagtgcc agcactacaa gccctttaag 2700 cagcttcata actgaaggtt gctgtggcat gggtccagga ccaccaactt tgctgggatc 2760 ctgtccctgg gtctttggat agccctgcct gaagcacctg tgatgggcta catgtttggt 2820 aaagtgatct atttcgctga tcttgtctcc aagagtgcca acgactgcca tacatcttag 2880 gaagacccaa tagggttaat cctgtcggaa gaagttgccc ttggaaacgt gtgtgaactg 2940 aagcatgctt cacatatcag caagttaccc aagggcaagc acagtgtcaa aggtttgggc 3000 aaaactactc ctgacctttc agctagtatc ccactggatg gtgtagaggt tcctcttggg 3060 accagggttt catctggtgt gaatgacacc tgtctactgt ataatgagta cattgtctat 3120 gatattgctc aggtaaatct gaaatatctg ctgaaactga aattcaattt taagacctcc 3180 ttgtggtaat tgggagaggt ggctgagtca cacacggtga ctctggtatt aattcaccct 3240 aagcgcttct gcaccaactc acctggctgg ctaagttgct ggtgggtagt acctgtacta 3300 aacctcctca gaaaggattt tgcagaaatg cattaaaagc tttttcccaa attttttagt 3360 ctcttgtttt gtgttgtgtt tgtggggagg ggttgttttt gttttttctt gccaggtaga 3420 taaaactgac aagctggaga gagattctgt ttgcatggat tagtcctctg gaaaaaacca 3480 agctgtgcta caatatctgc cttagtggtt tccccaggga agaaaaaata tgtttccacc 3540 cttttttttt gtttgtttgt ctttagtttt gattttggaa agatgttaag catttatttt 3600 tagttaaaaa taaaaattga tttcatacta aaaaaaagat gggttattga aaccctgtat 3660 gtcaccatac aatactccag ttctcccagt aaagaaacca gatgggtcat acagattagt 3720 gcaaaatcta 3730 <210> 465 <211> 1771 <212> DNA <213> Homo sapiens <400> 465 aagaagatgg aggaagtaaa ggaagccaac atccgagttg tgtctgagga cttcctccag 60 gacgtctccg cctccaccaa gagccttcag gagttgttct tagcgcacat cttgtcccct 120 tggggggcag aggtgaaggc agagcctgtt gaagttgtgg ccccaagagg gaagtcaggg 180 gctgcgctct ccaaaaaaag caagggccag gtcaaggagg aaggtatcaa caaatctgaa 240 aagagaatga aattaactct taaaggagga gcagctgtgg atcctgattc tggactggaa 300 cactctgcgc atgtcctgga gaaaggtggg aaggtcttca gtgccaccct tggcctggtg 360 gacatcgtta aaggaaccaa ctcctactac aagctgcagc ttctggagga cgacaaggaa 420 aacaggtatt ggatattcag gtcctggggc cgtgtgggta cggtgatcgg tagcaacaaa 480 ctggaacaga tgccgtccaa ggaggatgcc aatgagcact tcatgaaatt atatgaagaa 540 aaaaccggga acgcttggca ctccaaaaat ttcacgaagt atcccaaaaa gttctacccc 600 ctggagattg actatggcca ggatgaagag gcagtgaaga agctgacagt aaatcctggc 660 accaagtcca agctccccaa gccagttcag gacctcatca agatgatctt tgatgtggaa 720 agtatgaaga aagccatggt ggagtatgag atcgaccttc agaagatgcc cttggggaag 780 ctgagcaaaa ggcagatcca ggccgcatac tccatcctca gtgaggtcca gcaggcggtg 840 tctcagggca gcagcgactc tcagatcctg gatctctcaa atcgctttta caccctgatc 900 ccccacgact ttgggatgaa gaagcctccg ctcctgaaca atgcagacag tgtgcaggcc 960 aaggtggaaa tgcttgacaa cctgctggac atcgaggtgg cctacagtct gctcagggga 1020 gggtctgatg atagcagcaa ggatcccatc gatgtcaact atgagaagct caaaactgac 1080 attaaggtgg ttgacagaga ttctgaagaa gccgagatca tcaggaagta tgttaagaac 1140 actcatgcaa ccacacacaa tgcgtatgac ttggaagtca tcgatatctt taagatagag 1200 cgtgaaggcg aatgccagcg ttacaagccc tttaagcagc ttcataaccg aagattgctg 1260 tggcacgggt ccaggaccac caactttgct gggatcctgt cccagggtct tcggatagcc 1320 ccgcctgaag cgcccgtgac aggctacatg tttggtaaag ggatctattt cgctgacatg 1380 gtctccaaga gtgccaacta ctgccatacg tctcagggag acccaatagg cttaatcctg 1440 ttgggagaag ttgcccttgg aaacatgtat gaactgaagc acgcttcaca tatcagcaag 1500 ttacccaagg gcaagcacag tgtcaaaggt ttgggcaaaa ctacccctga tccttcagct 1560 aacattagtc tggatggtgt agacgttcct cttgggaccg ggatttcatc tggtgtgaat 1620 gacacctctc tactatataa cgagtacatt gtctatgata ttgctcaggt aaatctgaag 1680 tatctgctga aactgaaatt caattttaag acctccctgt ggtaattggg agaggtagcc 1740 gagtcacacc cggtggctct ggtatgaatt c 1771 <210> 466 <211> 827 <212> DNA <213> Homo sapiens <400> 466 ggcgtgttcg gtggcggctc tggccgctca ggcgcctgcg gctgggtgag cgcacgcgag 60 gcggcgaggc ggcagcgtgt ttctaggtcg tggcgtcggg cttccggagc tttggcggca 120 gctaggggag gatggcggag tcttcggata agctctatcg agtcgagtac gccaagagcg 180 ggcgcgcctc ttgcaagaaa tgcagcgaga gcatccccaa ggactcgctc cggatggcca 240 tcatggtgca gtcgcccatg tttgatggaa aagtcccaca ctggtaccac ttctcctgct 300 tctggaaggt gggccactcc atccggcacc ctgacgttga ggtggatggg ttctctgagc 360 ttcggtggga tgaccagcag aaagtcaaga agacagcgga agctggagga gtgacaggca 420 aaggccagga tggaattggt agcaaggcag agaagactct gggtgacttt gcagcagagt 480 atgccaagtc caacagaagt acgtgcaagg ggtgtatgga gaagatagaa aagggccagg 540 tgcgcctgtc caagaagatg gtggacccgg agaagccaca gctaggcatg attgaccgct 600 ggtaccatcc aggctgcttt gtcaagaaca gggaggagct gggtttccgg cccgagtaca 660 gtgcgagtca gctcaagggc ttcagcctcc ttgctacaga ggataaagaa gccctgaaga 720 agcagctccc aggagtcaag agtgaaggaa agagaaaagg cgatgaggtg gatggagtgg 780 atgaagtggc gaagaagaaa tctaaaaaaa aaaaaaaaaa aaaaaaa 827 <210> 467 <211> 695 <212> DNA <213> Homo sapiens <400> 467 ggaggatggc ggagtcttcg gataagctct atcgagtcga gtacgccaag agcgggcgcg 60 cctcttgcaa gaaatgcagc gagagcatcc ccaaggactc gctccggatg gccatcatgg 120 tgcagtcgcc catgtttgat ggaaaagtcc cacactggta ccacttctcc tgcttctgga 180 aggtgggcca ctccatccgg caccctgacg ttgaggtgga tgggttctct gagcttcggt 240 gggatgacca gcagaaagtc aagaagacag cggaagctgg aggagtgaca ggcaaaggcc 300 aggatggaat tggtagcaag gcagagaaga ctctgggtga ctttgcagca gagtatgcca 360 agtccaacag aagtacgtgc aaggggtgta tggagaagat agaaaagggc caggtgcgcc 420 tgtccaagaa gatggtggac ccggagaagc cacagctagg catgattgac cgctggtacc 480 atccaggctg ctttgtcaag aacagggagg agctgggttt ccggcccgag tacagtgcga 540 gtcagctcaa gggcttcagc ctccttgcta cagaggataa agaagccctg aagaagcagc 600 tcccaggagt caagagtgaa ggaaagagaa aaggcgatga ggtggatgga gtggatgaag 660 tggcgaagaa gaaatctaaa aaaaaaaaaa aaaaa 695 <210> 468 <211> 902 <212> DNA <213> Homo sapiens <400> 468 gaacggcggt ggccggtgcg gcgtgttcgg tggcggctct ggccgctcag gcgcctgcgg 60 ctgggtgagc gcacgcgagg cggcgaggcg gcagcgtgtt tctaggtcgt ggcgtcgggc 120 ttccggagct ttggcggcag ctaggggagg atggcggagt cttcggataa gctctatcga 180 gtcgagtacg ccaagagcgg gcgcgcctct tgcaagaaat gcagcgagag catccccaag 240 gactcgctcc ggatggccat catggtgcag tcgcccatgt ttgatggaaa agtcccacac 300 tggtaccact tctcctgctt ctggaaggtg ggccactcca tccggcaccc tgacgttgag 360 gtggatgggt tctctgagct tcggtgggat gaccagcaga aagtcaagaa gacagcggaa 420 gctggaggag tgacaggcaa aggccaggat ggaattggta gcaaggcaga gaagactctg 480 ggtgactttg cagcagagta tgccaagtcc aacagaagta cgtgcaaggg gtgtatggag 540 aagatagaaa agggccaggt gcgcctgtcc aagaagatgg tggacccgga gaagccacag 600 ctaggcatga ttgaccgctg gtaccatcca ggctgctttg tcaagaacag ggaggagctg 660 ggtttccggc ccgagtacag tgcgagtcag ctcaagggct tcagcctcct tgctacagag 720 gataaagaag ccctgaagaa gcagctccca ggagtcaaga gtgaaggaaa gagaaaaggc 780 gatgaggtgg atggagtgga tgaagtggcg aagaagaaat ctaaaaaaaa aaaaaaaaaa 840 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 900 aa 902 <210> 469 <211> 833 <212> DNA <213> Homo sapiens <400> 469 ggcggtggcc ggtgcggcgt gttcggtggc ggctctggcc gctcaggcgc ctgcggctgg 60 gtgagcgcac gcgaggcggc gaggcggcag cgtgtttcta ggtcgtggcg tcgggcttcc 120 ggagctttgc cggcagctag gggaggatgg cggagtcttc ggataagctc tatcgagtcg 180 agtacgccaa gagcgggcgc gcctcttgca agaaatgcag cgagagcatc cccaaggact 240 cgctccggat ggccatcatg gtgcagtcgc ccatgtttga tggaaaagtc ccacactggt 300 accacttctc ctgcttctgg aaggtgggcc actccatccg gcaccctgac gttgaggtgg 360 atgggttctc tgagcttcgg tgggatgatc agcagaaagt caagaagaca gcggaagctg 420 gaggagtgac aggcaaaggc caggatggaa ttggtagcaa ggcagagaag actctgggtg 480 actttgcagc agagtatgcc aagtccaaca gaagtacgtg caaggggtgt atggagaaga 540 tagaaaaggg ccaggtgcgc ctgtccaaga agatggtgga cccggagaag ccacagctag 600 gcatgattga ccgctggtac catccaggct gctttgtcaa gaacagggag gagctgggtt 660 tccggcccga gtacagtgcg agtcagctca agggcttcag cctccttgct acagaggata 720 aagaagccct gaagaagcag ctcccaggag tcaagagtga aggaaagaga aaaggcgatg 780 aggtggatgg agtggatgaa gtggcgaaga agaaatctaa aaaaaaaaaa aaa 833 <210> 470 <211> 3165 <212> DNA <213> Homo sapiens <400> 470 ccactgcagc ttctcttgat ggcaggcagt tcccaagata tgagcagtag caatatttgt 60 tggaggtgac tgatctgaaa gggacagcat tgatttgaat gtaagtccat aagttcagga 120 gtgtgtcctt tttaaaaata gtgttcaaca cttgaaaact cttggttctt ttccaggtgg 180 gaacccaggg gtgcacttaa ctaactgcct tggctctggg accccaggga aggccgctgg 240 gtggggtggt cagcatgatt tatgagccct catctgcaca tcagaattgg atgggaatta 300 tgctatatct tcgtccagac gtgctggact ttttgaaact gggcataggg gcagaggaga 360 catggttggc taagcccagc cgtaaaggaa gtgagcaaga atcttcagac acactgccat 420 ccctcatggt ggggtggggc tacagactct ggatttgggt cactggtgtc ctcaggaaat 480 cccagcaggc tcctgactgc tcctgttggg ggcctgaggg tgggctgccc ggtccagctc 540 tcctgcgacc acactgcaca gtgcccagct ttcagagcga aatcccctgt ctcctcagat 600 cgaccttcag aagatgccct tggggaagct gagcaaaagg cagatccagg ccgcatactc 660 catcctcagt gaggtccagc aggcggtgtc tcagggcagc agcgactctc agatcctgga 720 tctctcaaat cgcttttaca ccctgatccc ccacgacttt gggatgaaga agcctccgct 780 cctgaacaat gcagacagtg tgcaggccaa ggcggaaatg cttgacaacc tgctggacat 840 cgaggtggcc tacagtctgc tcaggggagg gtctgatgat agcagcaagg atcccatcga 900 tgtcaactat gagaagctca aaactgacat taaggtaaca gggtcaggcc ttcctcaagc 960 atcttaacct ctcatcctga gagcagcggt cccaaacttc catgtgtgtt aggatctcct 1020 ggaaagcttg ttaaaacaca ggtggctggc gcccaataat tcacttttct aacaagttcc 1080 cggacattgc tgctggtggt cctttgagaa cctttgggcg tttcacgtgt agataatgca 1140 ccttgtttgc aaggcagcct tccaagccag cacctcagct tggcgtacaa atttattttt 1200 gagggtctta ccaaaagttc ttttttgttt gtttgtttgt ttgtttcctc tccttaatct 1260 agagaggagc tctgtttttc taaacccttg tagcgtgaac ttttagaaga cttattaccg 1320 gtgtccattt cagaagtgga aatgcttgat ggcacctgta ataaaaacac aatgcttggg 1380 ttcatttttc tctggtgctg aagtggactg tgttggcaca cacagtctct gaacaccccg 1440 cttagaccaa ctagaggagg gatttttgcc tcagcttcta gatggcccgg tccttgagcc 1500 tatctccaca ctcatgtgcc ccattgtcct cagcccattc cctgcagtgt tgcaggggtt 1560 tgggtgggcg agagtatgtt gagtctggta ccaggtgttt acatcgctaa agaaagagcc 1620 ttggcttctt tcctaggaca aagtatagac ctatgggtcc aagcagggta agacaccaca 1680 tgtcatttgt tttgccccta gagcaccttc ctgatgggaa aactgtaggt gtggttcttc 1740 gtgaagggat tcttattctc tttttacaat tctgaagcct tttaattaaa agacagggag 1800 gtagaccagc attctaggtt ttctgaagtt tgaatataaa tatgaaaata aaacataact 1860 agtctcctcc gtaatactca ggcttactga gcatagatta catcagctat ttgacagatg 1920 cttgttaggc ctgtgctctg agccagggat aattttcatt gcacatcata gctgtgactt 1980 cctctggccc attgtgtttt aactcatgct gagctggact ctcttccagg agccaattgc 2040 ttgttctgga gatgccctgt tcactgacag tgaatcccac attctagctt ccctgatatc 2100 ccaaaacata gaattttaag acaaaaagga accctgagat tctctagcag cccaagtaga 2160 tgaagaggtg gaggcttagg taagtggagc cactggccca ggatctgccc agcccacagg 2220 cctgggacac aggctctcgg tcatgcccgg cttcctttga ggagtgtggt gttgagctat 2280 gcattgactg agcctgagca ttcctcctct gtagctctcc tgggtctctt ttgtgctaat 2340 cccaagattc tgtttatcca ggtggttgac agagattctg aagaagccga gatcatcagg 2400 aagtatgtta agaacactca tgcaaccaca cacaatgcgt atgacttgga agtcatcgat 2460 atctttaaga tagagcgtga aggcgaatgc cagcgttaca agccctttaa gcagcttcat 2520 aaccgaagat tgctgtggca cgggtccagg accaccaact ttgctgggat cctgtcccag 2580 ggtcttcgga tagccccgcc tgaagcgccc gtgacaggct acatgtttgg taaagggatc 2640 tatttcgctg acatggtctc caagagtgcc aactactgcc atacgtctca gggagaccca 2700 ataggcttaa tcctgttggg agaagttgcc cttggaaaca tgtatgaact gaagcacgct 2760 tcacatatca gcaagttacc caagggcaag cacagtgtca aaggtttggg caaaactacc 2820 cctgatcctt cagctaacat tagtctggat ggtgtagacg ttcctcttgg gaccgggatt 2880 tcatctggtg tgaatgacac ctctctacta tataacgagt acattgtcta tgatattgct 2940 caggtaaatc tgaagtatct gctgaaactg aaattcaatt ttaagacctc cctgtggtaa 3000 ttgggagagg tagccgagtc acacccggtg gctctggtat gaattcaccc gaagcgcttc 3060 tgcaccaact cacctggccg ctaagttgct gatgggtagt acctgtacta aaccacctca 3120 gaaaggattt tacagaaacg tgttaaaggt tttctctaac ttctc 3165 <210> 471 <211> 148 <212> DNA <213> Homo sapiens <400> 471 tgcgagtcag ctcaagggct tcagcctcct tgctacagag gataaagaag ccctgaagaa 60 gcagctccca ggagtcaaga gtgaaggaaa gagaaaaggc gatgaggtgg atggagtgga 120 tgaagtggcg aagaagaaat ctaaaaaa 148 <210> 472 <211> 1754 <212> DNA <213> Homo sapiens <400> 472 ccatggcggc gcggcggcga cggagcaccg gcggcggcag ggcgagagca ttaaatgaaa 60 gcaaaagagt taataatggc aacacggctc cagaagactc ttcccctgcc aagaaaactc 120 gtagatgcca gagacaggag tcgaaaaaga tgcctgtggc tggaggaaaa gctaataagg 180 acaggacaga agacaagcaa gatgaatctg tgaaggcctt gctgttaaag ggcaaagctc 240 ctgtggaccc agagtgtaca gccaaggtgg ggaaggctca tgtgtattgt gaaggaaatg 300 atgtctatga tgtcatgcta aatcagacca atctccagtt caacaacaac aagtactatc 360 tgattcagct attagaagat gatgcccaga ggaacttcag tgtttggatg agatggggcc 420 gagttgggaa aatgggacag cacagcctgg tggcttgttc aggcaatctc aacaaggcca 480 aggaaatctt tcagaagaaa ttccttgaca aaacgaaaaa caattgggaa gatcgagaaa 540 agtttgagaa ggtgcctgga aaatatgata tgctacagat ggactatgcc accaatactc 600 aggatgaaga ggaaacaaag aaagaggaat ctcttaaatc tcccttgaag ccagagtcac 660 agctagatct tcgggtacag gagttaataa agttgatctg taatgttcag gccatggaag 720 aaatgatgat ggaaatgaag tataatacca agaaagcccc acttgggaag ctgacagtgg 780 cacaaatcaa ggcaggttac cagtctctta agaagattga ggattgtatt cgggctggcc 840 agcatggacg agctctcatg gaagcatgca atgaattcta caccaggatt ccgcatgact 900 ttggactccg tactcctcca ctaatccgga cacagaagga actgtcagaa aaaatacaat 960 tactagaggc tttgggagac attgaaattg ctattaagct ggtgaaaaca gagctacaaa 1020 gcccagaaca cccattggac caacactata gaaacctaca ttgtgccttg cgcccccttg 1080 accatgaaag ttatgagttc aaagtgattt cccagtacct acaatctacc catgctccca 1140 cacacagcga ctataccatg accttgctgg atttgtttga agtggagaag gatggtgaga 1200 aagaagcctt cagagaggac cttcataaca ggatgcttct atggcatggt tccaggatga 1260 gtaactgggt gggaatcttg agccatgggc ttcgaattgc cccacctgaa gctcccatca 1320 caggttacat gtttgggaaa ggaatctact ttgctgacat gtcttccaag agtgccaatt 1380 actgctttgc ctctcgccta aagaatacag gactgctgct cttatcagag gtagctctag 1440 gtcagtgtaa tgaactacta gaggccaatc ctaaggccga aggattgctt caaggtaaac 1500 atagcaccaa ggggctgggc aagatggctc ccagttctgc ccacttcgtc accctgaatg 1560 ggagtacagt gccattagga ccagcaagtg acacaggaat tctgaatcca gatggttata 1620 ccctcaacta caatgaatat attgtatata accccaacca ggtccgtatg cggtaccttt 1680 taaaggttca gtttaatttc cttcagctgt ggtgaatgtt gatattaaat aaaccagaga 1740 tctgatcttc aagc 1754 <210> 473 <211> 1797 <212> DNA <213> Homo sapiens <400> 473 aaagagttaa taatggcaac acggctccag aagactcttc ccctgccaag aaaactcgta 60 gatgccagag acaggagtcg aaaaagatgc ctgtggctgg aggaaaagct aataaggaca 120 ggacagaaga caagcaagat ggtatgccag gaaggtcatg ggccagcaaa agggtctctg 180 aatctgtgaa ggccttgctg ttaaagggca aagctcctgt ggacccagag tgtacagcca 240 aggtggggaa ggctcatgtg tattgtgaag gaaatgatgt ctatgatgtc atgctaaatc 300 agaccaatct ccagttcaac aacaacaagt actatctgat tcagctatta gaagatgatg 360 cccagaggaa cttcagtgtt tggatgagat ggggccgagt tgggaaaatg ggacagcaca 420 gcctggtggc ttgttcaggc aatctcaaca aggccaagga aatctttcag aagaaattcc 480 ttgacaaaac gaaaaacaat tgggaagatc gagaaaagtt tgagaaggtg cctggaaaat 540 atgatatgct acagatggac tatgccacca atactcagga tgaagaggaa acaaagaaag 600 aggaatctct taaatctccc ttgaagccag agtcacagct agatcttcgg gtacaggagt 660 taataaagtt gatctgtaat gttcaggcca tggaagaaat gatgatggaa atgaagtata 720 ataccaagaa agccccactt gggaagctga cagtggcaca aatcaaggca ggttaccagt 780 ctcttaagaa gattgaggat tgtattcggg ctggccagca tggacgagct ctcatggaag 840 catgcaatga attctacacc aggatcccgc atgactttgg actccgtact cctccactaa 900 tccggacaca gaaggaactg tcagaaaaaa tacaattact agaggctttg ggagacattg 960 aaattgctat taagctggtg aaaacagagc tacaaagccc agaacaccca ttggaccaac 1020 actatagaaa cctacattgt gccttgcgcc cccttgacca tgaaagttat gagttcaaag 1080 tgatttccca gtacctacaa tctacccatg ctcccacaca cagcgactat accatgacct 1140 tgctggattt gtttgaagtg gagaaggatg gtgagaaaga agccttcaga gaggaccttc 1200 ataacaggat gcttctatgg catggttcca ggatgagtaa ctgggtggga atcttgagcc 1260 atgggcttcg aattgcccca cctgaagctc ccatcacagg ttacatgttt gggaaaggaa 1320 tctactttgc tgacatgtct tccaagagtg ccaattactg ctttgcctct cgcctaaaga 1380 atacaggact gctgctctta tcagaggtag ctctaggtca gtgtaatgaa ctactagagg 1440 ccaatcctaa ggccgaagga ttgcttcaag gtaaacatag caccaagggg ctgggcaaga 1500 tggctcccag ttctgcccac ttcgtcaccc tgaatgggag tacagtgcca ttaggaccag 1560 caagtgacac aggaattctg aatccagatg gttataccct caactacaat gaatatattg 1620 tatataaccc caaccaggtc cgtatgcggt accttttaaa ggttcagttt aatttccttc 1680 agctgtggtg aatgttgata ttaaataaac cagagatctg atcttcaagc aagaaaataa 1740 gcagtgttgt acttgtgaat tttgtgatat tttatgtaat aaaaactgta caggtct 1797 <210> 474 <211> 1980 <212> DNA <213> Homo sapiens <400> 474 attccatggc ggcgcggcgg cgacggagca ccggcggcgg cagggcgaga gcattaaatg 60 aaagcaaaag agttaataat ggcaacacgg ctccagaaga ctcttcccct gccaagaaaa 120 ctcgtagatg ccagagacag gagtcgaaaa agatgcctgt ggctggagga aaagctaata 180 aggacaggac agaagacaag caagatggta tgccaggaag gtcatgggcc agcaaaaggg 240 tctctgaatc tgtgaaggcc ttgctgttaa agggcaaagc tcctgtggac ccagagtgta 300 cagccaaggt ggggaaggct catgtgtatt gtgaaggaaa tgatgtctat gatgtcatgc 360 taaatcagac caatctccag ttcaacaaca acaagtacta tctgattcag ctattagaag 420 atgatgccca gaggaacttc agtgtttgga tgagatgggg ccgagttggg aaaatgggac 480 agcacagcct ggtggcttgt tcaggcaatc tcaacaaggc caaggaaatc tttcagaaga 540 aattccttga caaaacgaaa aacaattggg aagatcgaga aaagtttgag aaggtgcctg 600 gaaaatatga tatgctacag atggactatg ccaccaatac tcaggatgaa gaggaaacaa 660 agaaagagga atctcttaaa tctcccttga agccagagtc acagctagat cttcgggtac 720 aggagttaat aaagctgatc tgtaatgttc aggccatgga agaaatgatg atggaaatga 780 agtataatac caagaaagcc ccacttggga agctgacagt ggcacaaatc aaggcaggtt 840 accagtctct taagaagatt gaggattgta ttcgggctgg ccagcatgga cgagctctca 900 tggaagcatg caatgaattc tacaccagga ttccgcatga ctttggactc cgtactcctc 960 cactaatccg gacacagaag gaactgtcag aaaaaataca attactagag gctttgggag 1020 acattgaaat tgctattaag ctggtgaaaa cagagctaca aagcccagaa cacccattgg 1080 accaacacta tagaaaccta cattgtgcct tgcgccccct tgaccatgaa agttatgagt 1140 tcaaagtgat ttcccagtac ctacaatcta cccatgctcc cacacacagc gactatacca 1200 tgaccttgct ggatttgttt gaagtggaga aggatggtga gaaagaagcc ttcagagagg 1260 accttcataa caggatgctt ctatggcatg gttccaggat gagtaactgg gtgggaatct 1320 tgagccatgg gcttcgaatt gccccacctg aagctcccat cacaggttac atgtttggga 1380 aaggaatcta ctttgctgac atgtcttcca agagtgccaa ttactgcttt gcctctcgcc 1440 taaagcatac aggactgctg ctcttatcag aggtagctct aggtcagtgt aatgaactac 1500 tagaggccaa tcctaaggcc gaaggattgc ttcaaggtaa acatagcacc aaggggctgg 1560 gcaagatggc tcccagttct gcccacttcg tcaccctgta agtactcaga accaggagga 1620 ctagaagact ccttttggcc agataagact acgttctcta ttgcagcttc tgaaccagag 1680 actgatgttg acacactttt tttccatttg gcaggaatgg gagtacagtg ccattaggac 1740 cagcaagtga cacaggaatt ctgaatccag atggttatac cctcaactac aatgaatata 1800 ttgtatataa ccccaaccag gtccgtatgc ggtacctttt aaaggttcag tttaatttcc 1860 ttcagctgtg gtgaatgttg atcttaaata aaccagagat ctgatcttca agcaagaaaa 1920 taagcagtgt tgtacttgtg aattttgtga tattttatgt aataaaaact gtacaggtct 1980 <210> 475 <211> 1887 <212> DNA <213> Homo sapiens <400> 475 ccatggcggc gcggcggcga cggagcaccg gcggcggcag ggcgagagca ttaaatgaaa 60 gcaaaagagt taataatggc aacacggctc cagaagactc ttcccctgcc aagaaaactc 120 gtagatgcca gagacaggag tcgaaaaaga tgcctgtggc tggaggaaaa gctaataagg 180 acaggacaga agacaagcaa gatggtatgc caggaaggtc atgggccagc aaaagggtct 240 ctgaatctgt gaaggccttg ctgttaaagg gcaaagctcc tgtggaccca gagtgtacag 300 ccaaggtggg gaaggctcat gtgtattgtg aaggaaatga tgtctatgat gtcatgctaa 360 atcagaccaa tctccagttc aacaacaaca agtactatct gattcagcta ttagaagatg 420 atgcccagag gaacttcagt gtttggatga gatggggccg agttgggaaa atgggacagc 480 acagcctggt ggcttgttca ggcaatctca acaaggccaa ggaaatcttt cagaagaaat 540 tccttgacaa aacgaaaaac aattgggaag atcgagaaaa gtttgagaag gtgcctggaa 600 aatatgatat gctacagatg gactatgcca ccaatactca ggatgaagag gaaacaaaaa 660 aagaggaatc tcttaaatct cccttgaagc cagagtcaca gctagatctt cgggtacagg 720 agttaataaa gttgatctgt aatgttcagg ccatggaaga aatgatgatg gaaatgaagt 780 ataataccaa gaaagcccca cttgggaagc tgacagtggc acaaatcaag gcaggttacc 840 agtctcttaa gaagattgag gattgtattc gggctggcca gcatggacga gctctcatgg 900 aagcatgcaa tgaattctac accaggattc cgcatgactt tggactccgt actcctccac 960 taatccggac acagaaggaa ctgtcagaaa aaatacaatt actagaggct ttgggagaca 1020 ttgaaattgc tattaagctg gtgaaaacag agctacaaag cccagaacac ccattggacc 1080 aacactatag aaacctacat tgtgccttgc gcccccttga ccatgaaagt tacgagttca 1140 aagtgatttc ccagtaccta caatctaccc atgctcccac acacagcgac tataccatga 1200 ccttgctgga tttgtttgaa gtggagaagg atggtgagaa agaagccttc agagaggacc 1260 ttcataacag gatgcttcta tggcatggtt ccaggatgag taactgggtg ggaatcttga 1320 gccatgggct tcgaattgcc caccctgaag ctcccatcac aggttacatg tttgggaaag 1380 gaatctactt tgctgacatg tcttccaaga gtgccaatta ctgctttgcc tctcgcctaa 1440 agaatacagg actgctgctc ttatcagagg tagctctagg tcagtgtaat gaactactag 1500 aggccaatcc taaggccgaa ggattgcttc aaggtaaaca tagcaccaag gggctgggca 1560 agatggctcc cagttctgcc cacttcgtca ccctgaatgg gagtacagtg ccattaggac 1620 cagcaagtga cacaggaatt ctgaatccag atggttatac cctcaactac aatgaatata 1680 ttgtatataa ccccaaccag gtccgtatgc ggtacctttt aaaggttcag tttaatttcc 1740 ttcagctgtg gtgaatgttg atcttaaata aaccagagat ctgatcttca agcaagaaaa 1800 taagcagtgt tgtacttgtg aattttgtga tattttatgt aataaaaact gtacaggtct 1860 aaaaaaaaaa aaaaaaaaaa aaaaaaa 1887 <210> 476 <211> 1910 <212> DNA <213> Homo sapiens <400> 476 ctagaattca gcggccgctg aattctaggc ggcgcggcgg cgacggagca ccggcggcgg 60 cagggcgaga gcattaaatg aaagcaaaag agttaataat ggcaacacgg ctccagaaga 120 ctcttcccct gccaagaaaa ctcgtagatg ccagagacag gagtcgaaaa agatgcctgt 180 ggctggagga aaagctaata aggacaggac agaagacaag caagatggta tgccaggaag 240 gtcatgggcc agcaaaaggg tctctgaatc tgtgaaggcc ttgctgttaa agggcaaagc 300 tcctgtggac ccagagtgta cagccaaggt ggggaaggct catgtgtatt gtgaaggaaa 360 tgatgtctat gatgtcatgc taaatcagac caatctccag ttcaacaaca acaagtacta 420 tctgattcag ctattagaag atgatgccca gaggaacttc agtgtttgga tgagatgggg 480 ccgagttggg aaaatgggac agcacagcct ggtggcttgt tcaggcaatc tcaacaaggc 540 caaggaaatc tttcagaaga aattccttga caaaacgaaa aacaattggg aagatcgaga 600 aaagtttgag aaggtgcctg gaaaatatga tatgctacag atggactatg ccaccaatac 660 tcaggatgaa gaggaaacaa aaaaagagga atctcttaaa tctcccttga agccagagtc 720 acagctagat cttcgggtac aggagttaat aaagttgatc tgtaatgttc aggccatgga 780 agaaatgatg atggaaatga agtataatac caagaaagcc ccacttggga agctgacagt 840 ggcacaaatc aaggcaggtt accagtctct taagaagatt gaggattgta ttcgggctgg 900 ccagcatgga cgagctctca tggaagcatg caatgaattc tacaccagga ttccgcatga 960 ctttggactc cgtactcctc cactaatccg gacacagaag gaactgtcag aaaaaataca 1020 attactagag gctttgggag acattgaaat tgctattaag ctggtgaaaa cagagctaca 1080 aagcccagaa cacccattgg accaacacta tagaaaccta cattgtgcct tgcgccccct 1140 tgaccatgaa agttacgagt tcaaagtgat ttcccagtac ctacaatcta cccatgctcc 1200 cacacacagc gactatacca tgaccttgct ggatttgttt gaagtggaga aggatggtga 1260 gaaagaagcc ttcagagagg accttcataa caggatgctt ctatggcatg gttccaggat 1320 gagtaactgg gtgggaatct tgagccatgg gcttcgaatt gcccaccctg aagctcccat 1380 cacaggttac atgtttggga aaggaatcta ctttgctgac atgtcttcca agagtgccaa 1440 ttactgcttt gcctctcgcc taaagaatac aggactgctg ctcttatcag aggtagctct 1500 aggtcagtgt aatgaactac tagaggccaa tcctaaggcc gaaggattgc ttcaaggtaa 1560 acatagcacc aaggggctgg gcaagatggc tcccagttct gcccacttcg tcaccctgaa 1620 tgggagtaca gtgccattag gaccagcaag tgacacagga attctgaatc cagatggtta 1680 taccctcaac tacaatgaat atattgtata taaccccaac caggtccgta tgcggtacct 1740 tttaaaggtt cagtttaatt tccttcagct gtggtgaatg ttgatcttaa ataaaccaga 1800 gatctgatct tcaagcaaga aaataagcag tgttgtactt gtgaattttg tgatatttta 1860 tgtaataaaa actgtacagg tctaaaaaaa aaaaaaaaaa aaaaaaaaaa 1910 <210> 477 <211> 1745 <212> DNA <213> Homo sapiens <400> 477 ggaaccgacc gccgccggcc gggttgcagg cggggcacct cgggcaggac ctccctggtc 60 ggaagtggcc gtgagcccaa gccgcggtcc cgggccggca cccaggatgg gcgaggtgga 120 ggccccgggc cgcttgtggc tcgagagccc ccctggggga gcgcccccca tcttcctgcc 180 ctcggacggg caagccctgg tcctgggcag gggacccctg acccaggtta cggaccggaa 240 gtgctccaga actcaagtgg agctggtcgc agatcctgag acccggacag tggcagtgaa 300 acagctggga gttaacccct caactaccgg gacccaggag ttgaagccgg ggttggaggg 360 ctctctgggg gtgggggaca cactgtattt ggtcaatggc ctccacccac tgaccctgcg 420 ctgggaagag acccgcacac cagaatccca gccagatact ccgcctggca cccctctggt 480 gtcccaagat gagaagagag atgctgagct gccgaagaag cgtatgcgga agtcaaaccc 540 cggctgggag aacttggaga agttgctagt gttcaccgca gctggggtga aaccccaggg 600 caaggtggct ggctttgatc tggacgggac gctcatcacc acacgctctg ggaaggtctt 660 tcccactggc cccagtgact ggaggatctt gtacccagag attccccgta agctccgaga 720 gctggaagcc gagggctaca agctggtgat cttcaccaac cagatgagca tcgggcgcgg 780 gaagctgcca gccgaggagt tcaaggccaa ggtggaggct gtggtggaga agctgggggt 840 ccccttccag gtgctggtgg ccacgcacgc aggcttgtac cggaagccgg tgacgggcat 900 gtgggaccat ctgcaggagc aggccaacga cggcacgccc atatccatcg gggacagcat 960 ctttgtggga gacgcagccg gacgcccggc caactgggcc ccggggcgga agaagaaaga 1020 cttctcctgc gccgatcgcc tgtttgccct caaccttggc ctgcccttcg ccacgcctga 1080 ggagttcttt ctcaagtggc cagcagccgg cttcgagctc ccagcctttg atccgaggac 1140 tgtctcccgc tcagggcctc tctgcctccc cgagtccagg gccctcctga gcgccagccc 1200 ggaggtggtt gtcgcagtgg gattccctgg ggccgggaag tccacctttc tcaagaagca 1260 cctcgtgtcg gccggatatg tccacgtgaa cagggacacg ctaggctcct ggcagcgctg 1320 tgtgaccacg tgtgagacag ccctgaagca agggaaacgg gtcgccatcg acaacacaaa 1380 cccagacgcc gcgagccgcg ccaggtacgt ccagtgtgcc cgagccgcgg gcgtcccctg 1440 ccgctgcttc ctcttcaccg ccactctgga gcaggcgcgc cacaacaacc ggtttcgaga 1500 gatgacggac tcctctcata tccccgtgtc agacatggtc atgtatggct acaggaagca 1560 gttcgaggcc ccaacgctgg ctgaaggctt ctctgccatc ctggagatcc cgttccggct 1620 atgggtggag ccgaggctgg ggcggctgta ctgccagttc tccgagggct gagccccgcc 1680 cagctcccct ccacaataaa cgctgtttct ccttgaaaaa aaaaaaaaaa aaaaaaaaaa 1740 aaaaa 1745 <210> 478 <211> 1745 <212> DNA <213> Homo sapiens <400> 478 ggaaccgacc gccgccggcc gggttgcagg cggggcacct cgggcaggac ctccctggtc 60 ggaagtggcc gtgagcccaa gccgcggtcc cgggccggca cccaggatgg gcgaggtgga 120 ggccccgggc cgcttgtggc tcgagagccc ccctggggga gcgcccccca tcttcctgcc 180 ctcggacggg caagccctgg tcctgggcag gggacccctg acccaggtta cggaccggaa 240 gtgctccaga actcaagtgg agctggtcgc agatcctgag acccggacag tggcagtgaa 300 acagctggga gttaacccct caactaccgg gacccaggag ttgaagccgg ggttggaggg 360 ctctctgggg gtgggggaca cactgtattt ggtcaatggc ctccacccac tgaccctgcg 420 ctgggaagag acccgcacac cagaatccca gccagatact ccgcctggca cccctctggt 480 gtcccaagat gagaagagag atgctgagct gccgaagaag cgtatgcgga agtcaaaccc 540 cggctgggag aacttggaga agttgctagt gttcaccgca gctggggtga aaccccaggg 600 caaggtggct ggctttgatc tggacgggac gctcatcacc acacgctctg ggaaggtctt 660 tcccactggc cccagtgact ggaggatctt gtacccagag attccccgta agctccgaga 720 gctggaagcc gagggctaca agctggtgat cttcaccaac cagatgagca tcgggcgcgg 780 gaagctgcca gccgaggagt tcaaggccaa ggtggaggct gtggtggaga agctgggggt 840 ccccttccag gtgctggtgg ccacgcacgc aggcttgtac cggaagccgg tgacgggcat 900 gtgggaccat ctgcaggagc aggccaacga cggcacgccc atatccatcg gggacagcat 960 ctttgtggga gacgcagccg gacgcccggc caactgggcc ccggggcgga agaagaaaga 1020 cttctcctgc gccgatcgcc tgtttgccct caaccttggc ctgcccttcg ccacgcctga 1080 ggagttcttt ctcaagtggc cagcagccgg cttcgagctc ccagcctttg atccgaggac 1140 tgtctcccgc tcagggcctc tctgcctccc cgagtccagg gccctcctga gcgccagccc 1200 ggaggtggtt gtcgcagtgg gattccctgg ggccgggaag tccacctttc tcaagaagca 1260 cctcgtgtcg gccggatatg tccacgtgaa cagggacacg ctaggctcct ggcagcgctg 1320 tgtgaccacg tgtgagacag ccctgaagca agggaaacgg gtcgccatcg acaacacaaa 1380 cccagacgcc gcgagccgcg ccaggtacgt ccagtgtgcc cgagccgcgg gcgtcccctg 1440 ccgctgcttc ctcttcaccg ccactctgga gcaggcgcgc cacaacaacc ggtttcgaga 1500 gatgacggac tcctctcata tccccgtgtc agacatggtc atgtatggct acaggaagca 1560 gttcgaggcc ccaacgctgg ctgaaggctt ctctgccatc ctggagatcc cgttccggct 1620 atgggtggag ccgaggctgg ggcggctgta ctgccagttc tccgagggct gagccccgcc 1680 cagctcccct ccacaataaa cgctgtttct ccttgaaaaa aaaaaaaaaa aaaaaaaaaa 1740 aaaaa 1745 <210> 479 <211> 1636 <212> DNA <213> Homo sapiens <400> 479 atgggcgagg tggagccccc gggccgcttg tggctcgaga gcccccctgg gggagcgccc 60 cccatcttcc tgccctcgga cgggcaagcc ctggtcctgg gcaggggacc cctgacccag 120 gttacggacc ggaagtgctc cagaactcaa gtggagctgg tcgcagatcc tgagacccgg 180 acagtggcag tgaaacagct gggagttaac ccctcaacta ccgggaccca ggagttgaag 240 ccggggttgg agggctctct gggggtgggg gacacactgt atttggtcaa tggcctccac 300 ccactgaccc tgcgctggga agagacccgc acaccagaat cccagccaga tactccgcct 360 ggcacccctc tggtgtccca agatgagaag agagatgctg agctgccgaa gaagcgtatg 420 cggaagtcaa accccggctg ggagaacttg gagaagttgc tagtgttcac cgcagctggg 480 gtgaaacccc agggcaaggt ggctggcttt gatctggacg ggacgctcat caccacacgc 540 tctgggaagg tctttcccac tggccccagt gactggagga tcttgtaccc agagattccc 600 cgtaagctcc gagagctgga agccgagggc tacaagctgg tgatcttcac caaccagatg 660 agcatcgggc gcgggaagct gccagccgag gagttcaagg ccaaggtgga ggctgtggtg 720 gagaagctgg gggtcccctt ccaggtgctg gtggccacgc acgcaggctt gtaccggaag 780 ccggtgacgg gcatgtggga ccatctgcag gagcaggcca acgacggcac gcccatatcc 840 atcggggaca gcatctttgt gggagacgca gccggacgcc cggccaactg ggccccgggg 900 cggaagaaga aagacttctc ctgcgccgat cgcctgtttg ccctcaacct tggcctgccc 960 ttcgccacgc ctgaggagtt ctttctcaag tggccagcag ccggcttcga gctcccagcc 1020 tttgatccga ggactgtctc ccgctcaggg cctctctgcc tccccgagtc cagggccctc 1080 ctgagcgcca gcccggaggt ggttgtcgca gtgggattcc ctggggccgg gaagtccacc 1140 tttctcaaga agcacctcgt gtcggccgga tatgtccacg tgaacaggga cacgctaggc 1200 tcctggcagc gctgtgtgac cacgtgtgag acagccctga agcaagggaa acgggtcgcc 1260 atcgacaaca caaacccaga cgccgcgagc cgcgccaggt acgtccagtg tgcccgagcc 1320 gcgggcgtcc cctgccgctg cttcctcttc accgccactc tggagcaggc gcgccacaac 1380 aaccggtttc gagagatgac ggactcctct catatccccg tgtcagacat ggtcatgtat 1440 ggctacagga agcagttcga ggccccaacg ctggctgaag gcttctctgc catcctggag 1500 atcccgttcc ggctatgggt ggagccgagg ctggggcggc tgtactgcca gttctccgag 1560 ggctgagccc cgcccagctc ccctccacaa taaacgctgt ttctccttga aaaaaaaaaa 1620 aaaaaaaaaa aaaaaa 1636 <210> 480 <211> 1635 <212> DNA <213> Homo sapiens <400> 480 atgggcgagg tggaggcccc gggccgcttg tggctcgaga gcccccctgg ggaggcgccc 60 cccatcttcc tgccctcgga cgggcaagcc ctggtcctgg gcaggggacc cctgacccag 120 gttacggacc ggaagtgctc cagaactcaa gtggagctgg tcgcagatcc tgagacccgg 180 acagtggcag tgaaacagct gggagttaac ccctcaacta ccgggaccca ggagttgaag 240 ccggggttgg agggctctct gggggtgggg gacacactgt atttggtcaa tggcctccac 300 ccactgaccc tgcgctggga agagacccgc acaccagaat cccagccaga tactccgcct 360 ggcacccctc tggtgtccca agatgagaag agagatgctg agctgccgaa gaagcgtatg 420 cggaagtcaa accccggctg ggagaacttg gagaagttgc tagtgttcac cgcagctggg 480 gtgaaacccc agggcaaggt ggctggcttt gatctggacg ggacgctcat caccacacgc 540 tctgggaagg tctttcccac tggccccagt gactggagga tcttgtaccc agagattccc 600 cgtaagctcc gagagctgga agccgagggc tacaagctgg tgatcttcac caaccagatg 660 agcatcgggc gcgggaagct gccagccgag gagttcaagg ccaaggtgga ggctgtggtg 720 gagaagctgg gggtcccctt ccaggtgctg gtggccacgc acgcaggctt gtaccggaag 780 ccggtgacgg gcatgtggga ccatctgcag gagcaggcca acgacggcac gcccatatcc 840 atcggggaca gcatctttgt gggagacgca gccggacgcc cggccaactg ggccccgggg 900 cggaagaaga aagacttctc ctgcgccgat cgcctgtttg ccctcaacct tggcctgccc 960 ttcgccacgc ctgaggagtt ctttctcaag tggccagcag ccggcttcga gctcccagcc 1020 tttgatccga ggactgtctc ccgctcaggg cctctctgcc tccccgagtc cagggccctc 1080 ctgagcgcca gcccggaggt ggttgtcgca gtgggattcc ctggggccgg gaagtccacc 1140 tttctcaaga agcacctcgt gtcggccgga tatgtccacg tgaacaggga cacgctaggc 1200 tcctggcagc gctgtgtgac cacgtgtgag acagccctga agcaagggaa acgggtcgcc 1260 atcgacaaca caaacccaga cgccgcgagc cgcgccaggt acgtccagtg tgcccgagcc 1320 gcgggcgtcc cctgccgctg cttcctcttc accgccactc tggagcaggc gcgccacaac 1380 aaccggtttc gagagatgac ggactcctct catatccccg tgtcagacat ggtcatgtat 1440 ggctacagga agcagttcga ggccccaacg ctggctgaag gcttctctgc catcctggag 1500 atcccgttcc ggctatgggt ggagccgagg ctggggcggc tgtactgcca gttctccgag 1560 ggctgagccc cgcccagctc ccctccacaa taaacgctgt ttctccttga aaaaaaaaaa 1620 aaaaaaaaaa aaaaa 1635 <210> 481 <211> 1730 <212> DNA <213> Homo sapiens <220> <221> misc_feature <222> (1470)..(1470) <223> "n" means any of A, T, G, and C. <400> 481 ggccgcgtcg acccgggttg caggcggggc acctcgggca ggacctccct ggtcggaagt 60 ggccgtgagc ccaagccgcg gtcccgggcc ggcacccagg atgggcgagg tggaggcccc 120 gggccgcttg tggctcgaga gcccccctgg gggagcgccc cccatcttcc tgccctcgga 180 cgggcaagcc ctggtcctgg gcaggggacc cctgacccag gttacggacc ggaagtgctc 240 cagaactcaa gtggagctgg tcgcagatcc tgagacccgg acagtggcag tgaaacagct 300 gggagttaac ccctcaacta ccgggaccca ggagttgaag ccggggttgg agggctctct 360 gggggtgggg gacacactgt atttggtcaa tggcctccac ccactgaccc tgcgctggga 420 agagacccgc acaccagaat cccagccaga tactccgcct ggcacccctc tggtgtccca 480 agatgagaag agagatgctg agctgccgaa gaagcgtatg cggaagtcaa accccggctg 540 ggagaacttg gagaagttgc tagtgttcac cgcagctggg gtgaaacccc agggcaaggt 600 ggctggcttt gatctggacg ggacgctcat caccacacgc tctgggaagg tctttcccac 660 tggccccagt gactggagga tcttgtaccc agagattccc cgtaagctcc gagagctgga 720 agccgagggc tacaagctgg tgatcttcac caaccagatg agcatcgggc gcgggaagct 780 gccagccgag gagttcaagg ccaaggtgga ggctgtggtg gagaagctgg gggtcccctt 840 ccaggtgctg gtggccacgc acgcaggctt gtaccggaag ccggtgacgg gcatgtggga 900 ccatctgcag gagcaggcca acgacggcac gcccatatcc atcggggaca gcatctttgt 960 gggagacgca gccggacgcc cggccaactg ggccccgggg cggaagaaga aagacttctc 1020 ctgcgccgat cgcctgtttg ccctcaacct tggcctgccc ttcgccacgc ctgaggagtt 1080 ctttctcaag tggccagcag ccggcttcga gctcccagcc tttgatccga ggactgtctc 1140 ccgctcaggg cctctctgcc tccccgagtc cagggccctc ctgagcgcca gcccggaggt 1200 ggttgtcgca gtgggattcc ctggggccgg gaagtccacc tttctcaaga agcacctcgt 1260 gtcggccgga tatgtccacg tgacagggac acgctaggct cctggcagcg ctgtgtgacc 1320 acgtgtgaga cagccctgaa gcaagggaaa cgggtcgcca tcgacaacac aaacccagac 1380 gccgcgagcc gcgccaggta cgtccagtgt gcccgagccg cgggcgtccc ctgccgctgc 1440 ttcctcttca ccgccactct ggagcaggcn gctgccacaa caaccggttt cgagagatga 1500 cggactcctc tcatatcccc gtgtcagaca tggtcatgta tggctacagg aagcagttcg 1560 aggccccaac gctggctgaa ggcttctctg ccatcctgga gatcccgttc cggctatggg 1620 tggagccgag gctggggcgg ctgtactgcc agttctccga gggctgagcc ccgcccagct 1680 cccctccaca ataaacgctg tttctcctta aaaaaaaaaa aaaaaaaaaa 1730 <210> 482 <211> 1627 <212> DNA <213> Homo sapiens <400> 482 ggaccggaag tgctccagaa ctcaagcctg aagcaggcca cactccccag aaatgaggga 60 cccaatcaca caaggatgca aatcctgact ccacccctcc aatcctcagt ggagctggtc 120 gcagatcctg agacccggac agtggcagtg aaacagctgg gagttaaccc ctcaactacc 180 gggacccagg agttgaagcc ggggttggag ggctctctgg gggtggggga cacactgtat 240 ttggtcaatg gcctccaccc actgaccctg cgctgggaag agacccgcac accagaatcc 300 cagccagata ctccgcctgg cacccctctg gtgtcccaag atgagaagag agatgctgag 360 ctgccgaaga agcgtatgcg gaagtcaaac cccggctggg agaacttgga gaagttgcta 420 gtgttcaccg cagctggggt gaaaccccag ggcaaggtgg ctggctttga tctggacggg 480 acgctcatca ccacacgctc tgggaaggtc tttcccactg gccccagtga ctggaggatc 540 ttgtacccag agattccccg taagctccga gagctggaag ccgagggcta caagctggtg 600 atcttcacca accagatgag catcgggcgc gggaagctgc cagccgagga gttcaaggcc 660 aaggtggagg ctgtggtgga gaagctgggg gtccccttcc aggtgctggt ggccacgcac 720 gcaggcttgt accggaagcc ggtgacgggc atgtgggacc atctgcagga gcaggccaac 780 gacggcacgc ccatatccat cggggacagc atctttgtgg gagacgcagc cggacgcccg 840 gccaactggg ccccggggcg gaagaagaaa gacttctcct gcgccgatcg cctgtttgcc 900 ctcaaccttg gcctgccctt cgccacgcct gaggagttct ttctcaagtg gccagcagcc 960 ggcttcgagc tcccagcctt tgatccgagg actgtctccc gctcagggcc tctctgcctc 1020 cccgagtcca gggccctcct gagcgccagc ccggaggtgg ttgtcgcagt gggattccct 1080 ggggccggga agtccacctt tctcaagaag cacctcgtgt cggccggata tgtccacgtg 1140 aacagggaca cgctaggctc ctggcagcgc tgtgtgacca cgtgtgagac agccctgaag 1200 caagggaaac gggtcgccat cgacaacaca aacccagacg ccgcgagccg cgccaggtac 1260 gtccagtgtg cccgagccgc gggcgtcccc tgccgctgct tcctcttcac cgccactctg 1320 gagcaggcgc gccacaacaa ccggtttcga gagatgacgg actcctctca tatccccgtg 1380 tcagacatgg tcatgtatgg ctacaggaag cagttcgagg ccccaacgct ggctgaaggc 1440 ttctctgcca tcctggagat cccgttccgg ctatgggtgg agccgaggct ggggcggctg 1500 tactgccagt tctccgaggg ctgagccccg cccagctccc ctccacaata aacgctgttt 1560 ctccttgaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1620 aaaaaaa 1627 <210> 483 <211> 1538 <212> DNA <213> Homo sapiens <400> 483 ggcacgaggg cacccaggat gggcgaggtg gaggccccgg gccgcttgtg gctcgagagc 60 ccccctgggg gagcgccccc catcttcctg ccctcggacg ggcaagccct ggtcctgggc 120 aggggacccc tgacccaggt tacggaccgg aagtgctcca gaactcaagt ggagctggtc 180 gcagatcctg agacccggac agtggcagtg aaacagctgg gagttaaccc ctcaactacc 240 gggacccagg agttgaagcc ggggttggag ggctctctgg gggtggggga cacactgtat 300 ttggtcaatg gcctccaccc actgaccctg cgctgggaag agacccgcac accagaatcc 360 cagccagata ctccgcctgg cacccctctg gtgtcccaag atgagaagag agatgctgag 420 ctgccgaaga agcgtatgcg gaagtcaaac cccggctggg agaacttgga gaagttgcta 480 gtgttcaccg cagctggggt gaaaccccag ggcaaggtgg ctggctttga tctggacggg 540 acgctcatca ccacacgctc tgggaaggtc tttcccactg gccccagtga ctggaggatc 600 ttgtacccag agattccccg taagctccga gagctggaag ccgagggcta caagctggtg 660 atcttcacca accagatgag catcgggcgc gggaagctgc cagccgagga gttcaaggcc 720 aaggtggagg ctgtggtgga gaagctgggg gtccccttcc aggtgctggt ggccacgcac 780 gcaggcttgt accggaagcc ggtgacgggc atgtgggacc atctgcagga gcaggccaac 840 gacggcacgc ccatatccat cggggacagc atctttgtgg gagacgcagc cggacgcccg 900 gccaactggg ccccggggcg gaagaagaaa gacttctcct gcgccgatcg cctgtttgcc 960 ctcaaccttg gcctgccctt cgccacgcct gaggagttct ttctcaagtg gccagcagcc 1020 ggcttcgagc tcccagcctt tgatccgagg actgtctccc gctcagggcc tctctgcctc 1080 cccgagtcca gggccctcct gagcgccagc ccggaggtgg ttgtcgcagt gggattccct 1140 ggggccggga agtccacctt tctcaagaag cacctcgtgt cggccggata tgtccacgtg 1200 aacagggtac gtccagtgtg cccgagccgc gggcgtcccc tgccgctgct tcctcttcac 1260 cgccactctg gagcaggcgc gccacaacaa ccggtttcga gagatgacgg actcctctca 1320 tatccccgtg tcagacatgg tcatgtatgg ctacaggaag cagttcgagg ccccaacgct 1380 ggctgaaggc ttctctgcca tcctggagat cccgttccgg ctatgggtgg agccgaggct 1440 ggggcggctg tactgccagt tctccgaggg ctgagccccg cccagctccc ctccacaata 1500 aacgctgttt ctccttgaaa aaaaaaaaaa aaaaaaaa 1538 <210> 484 <211> 2121 <212> DNA <213> Homo sapiens <400> 484 atccagaggg acgcttggct gctacgcggg attgcagtgg tgcagccagc cccgaagtcg 60 gaaggtgctc tctagggagt acaggaagat aaagtttgtg cttgatttag aattagctag 120 atcctttggg ggagagggga tcgagccgat ttcgggagga tgttcactgc gcggatgatg 180 ctcaggccat cgagaaatcc agaaacaggc gacgaccttc gtcaagagaa aaatgatcct 240 gtggagaaaa gtaaatgtcg ctaggttggg atggatggta acaggccaag ccccggacct 300 atatctagcc acattttttg tcaaggagga aaccaattct gtagagaaaa gtacctccct 360 gtcccttgca aggaccagtg tcaggcaatc ctagtgccac tatctggcta ctgcatgtca 420 aggagccaat cccatgtaga aataaactgc ctcttactcc ctggatgcta tagcctgaag 480 caggccacac tccccagaaa tgagggaccc aatcacacaa ggatgcaaat cctgactcca 540 cccctccaat cctcagtgga gctggtcgca gatcctgaga cccggacagt ggcagtgaaa 600 cagctgggag ttaacccctc aactaccggg acccaggagt tgaagccggg gttggagggc 660 tctctggggg tgggggacac actgtatttg gtcaatggcc tccacccact gaccctgcgc 720 tgggaagaga cccgcacacc agaatcccag ccagatactc cgcctggcac ccctctggtg 780 tcccaagatg agaagagaga tgctgagctg ccgaagaagc gtatgcggaa gtcaaacccc 840 ggctgggaga acttggagaa gttgctagtg ttcaccgcag ctggggtgaa accccagggc 900 aaggtggctg gctttgatct ggacgggacg ctcatcacca cacgctctgg gaaggtcttt 960 cccactggcc ccagtgactg gaggtgataa gaggcaaaac aagggagtga gtgaggcctg 1020 gagtccacct ctggccccgg gtcacccctg ccgcttcata cctgccgtag gatcttgtac 1080 ccagagattc cccgtaagct ccgagagctg gaagccgagg gctacaagct ggtgatcttc 1140 accaaccaga tgagcatcgg gcgcgggaag ctgccagccg aggagttcaa ggccaaggtg 1200 gaggctgtgg tggagaagct gggggtcccc ttccaggtgc tggtggccac gcacgcaggc 1260 ttgtaccgga agccggtgac gggcatgtgg gaccatctgc aggagcaggc caacgacggc 1320 acgcccatat ccatcgggga cagcatcttt gtgggagacg cagccggacg cccggccaac 1380 tgggccccgg ggcggaagaa gaaagacttc tcctgcgccg atcgcctgtt tgccctcaac 1440 cttggcctgc ccttcgccac gcctgaggag ttctttctca agtggccagc agccggcttc 1500 gagctcccag cctttgatcc gaggactgtc tcccgctcag ggcctctctg cctccccgag 1560 tccagggccc tcctgagcgc cagcccggag gtggttgtcg cagtgggatt ccctggggcc 1620 gggaagtcca cctttctcaa gaagcacctc gtgtcggccg gatatgtcca cgtgaacagg 1680 gacacgctag gctcctggca gcgctgtgtg accacgtgtg agacagccct gaagcaaggg 1740 aaacgggtcg ccatcgacaa cacaaaccca gacgccgcga gccgcgccag gtacgtccag 1800 tgtgcccgag ccgcgggcgt cccctgccgc tgcttcctct tcaccgccac tctggagcag 1860 gcgcgccaca acaaccggtt tcgagagatg acggactcct ctcatatccc cgtgtcagac 1920 atggtcatgt atggctacag gaagcagttc gaggccccaa cgctggctga aggcttctct 1980 gccatcctgg agatcccgtt ccggctatgg gtggagccga ggctggggcg gctgtactgc 2040 cagttctccg agggctgagc cccgcccagc tcccctccac aataaacgct gtttctcctt 2100 gaaaaaaaaa aaaaaaaaaa a 2121 <210> 485 <211> 1259 <212> DNA <213> Homo sapiens <400> 485 ccggagctgg gttgctcctg ctcccgtctc caagtcctgg tacctccttc aagctgggag 60 agggctctag tccctggttc tgaacactct ggggttctcg ggtgcaggcc gccatgagca 120 aacggaaggc gccgcaggag actctcaacg ggggaatcac cgacatgctc acagaactcg 180 caaactttga gaagaacgtg agccaagcta tccacaagta caatgcttac agaaaagcag 240 catctgttat agcaaaatac ccacacaaaa taaagagtgg agctgaagct aagaaattgc 300 ctggagtagg aacaaaaatt gctgaaaaga ttgatgagtt tttagcaact ggaaaattac 360 gtaaactgga aaagattcgg caggatgata cgagttcatc catcaatttc ctgactcgag 420 ttagtggcat tggtccatct gctgcaagga agtttgtaga tgaaggaatt aaaacactag 480 aagatctcag aaaaaatgaa gataaattga accatcatca gcgaattggg ctgaaatatt 540 ttggggactt tgaaaaaaga attcctcgtg aagagatgtt acaaatgcaa gatattgtac 600 taaatgaagt taaaaaagtg gattctgaat acattgctac agtctgtggc agtttcagaa 660 gaggtgcaga gtccagtggt gacatggatg ttctcctgac ccatcccagc ttcacttcag 720 aatcaaccaa acagccaaaa ctgttacatc aggttgtgga gcagttacaa aaggttcatt 780 ttatcacaga taccctgtca aagggtgaga caaagttcat gggtgtttgc cagcttccca 840 gtaaaaatga tgaaaaagaa tatccacaca gaagaattga tatcaggttg atacccaaag 900 atcagtatta ctgtggtgtt ctctatttca ctgggagtga tattttcaat aagaatatga 960 gggctcatgc cctagaaaag ggtttcacaa tcaatgagta caccatccgt cccttgggag 1020 tcactggagt tgcaggagaa cccctgccag tggatagtga aaaagacatc tttgattaca 1080 tccagtggaa ataccgggaa cccaaggacc ggagcgaatg aggcctgtat cctccctggc 1140 agacacaacc caataggagt cttaatttat ttcttaacct ttgctatgta agggtctttg 1200 gtgtttttaa atgattgttt cttcttcatg cttttgcttg caatgtagtc aataaaacc 1259 <210> 486 <211> 1259 <212> DNA <213> Homo sapiens <400> 486 ccggagctgg gttgctcctg ctcccgtctc caagtcctgg tacctccttc aagctgggag 60 agggctctag tccctggttc tgaacactct ggggttctcg ggtgcaggcc gccatgagca 120 aacggaaggc gccgcaggag actctcaacg ggggaatcac cgacatgctc acagaactcg 180 caaactttga gaagaacgtg agccaagcta tccacaagta caatgcttac agaaaagcag 240 catctgttat agcaaaatac ccacacaaaa taaagagtgg agctgaagct aagaaattgc 300 ctggagtagg aacaaaaatt gctgaaaaga ttgatgagtt tttagcaact ggaaaattac 360 gtaaactgga aaagattcgg caggatgata cgagttcatc catcaatttc ctgactcgag 420 ttagtggcat tggtccatct gctgcaagga agtttgtaga tgaaggaatt aaaacactag 480 aagatctcag aaaaaatgaa gataaattga accatcatca gcgaattggg ctgaaatatt 540 ttggggactt tgaaaaaaga attcctcgtg aagagatgtt acaaatgcaa gatattgtac 600 taaatgaagt taaaaaagtg gattctgaat acattgctac agtctgtggc agtttcagaa 660 gaggtgcaga gtccagtggt gacatggatg ttctcctgac ccatcccagc ttcacttcag 720 aatcaaccaa acagccaaaa ctgttacatc aggttgtgga gcagttacaa aaggttcatt 780 ttatcacaga taccctgtca aagggtgaga caaagttcat gggtgtttgc cagcttccca 840 gtaaaaatga tgaaaaagaa tatccacaca gaagaattga tatcaggttg atacccaaag 900 atcagtatta ctgtggtgtt ctctatttca ctgggagtga tattttcaat aagaatatga 960 gggctcatgc cctagaaaag ggtttcacaa tcaatgagta caccatccgt cccttgggag 1020 tcactggagt tgcaggagaa cccctgccag tggatagtga aaaagacatc tttgattaca 1080 tccagtggaa ataccgggaa cccaaggacc ggagcgaatg aggcctgtat cctccctggc 1140 agacacaacc caataggagt cttaatttat ttcttaacct ttgctatgta agggtctttg 1200 gtgtttttaa atgattgttt cttcttcatg cttttgcttg caatgtagtc aataaaacc 1259 <210> 487 <211> 1008 <212> DNA <213> Homo sapiens <400> 487 atgagcaaac ggaaggcgcc gcaggagact ctcaacgggg gaatcaccga catgctcaca 60 gaactcgcaa actttgagaa gaacgtgagc caagctatcc acaagtacaa tgcttacaga 120 aaagcagcat ctgttatagc aaaataccca cacaaaataa agagtggagc tgaagctaag 180 aaattgcctg gagtaggaac aaaaattgct gaaaagattg atgagttttt agcaactgga 240 aaattacgta aactggaaaa gattcggcag gatgatacga gttcatccat caatttcctg 300 actcgagtta gtggcattgg tccatctgct gcaaggaagt ttgtagatga aggaattaaa 360 acactagaag atctcagaaa aaatgaagat aaattgaacc atcatcagcg aattgggctg 420 aaatattttg gggactttga aaaaagaatt cctcgtgaag agatgttaca aatgcaagat 480 attgtactaa atgaagttaa aaaagtggat tctgaataca ttgctacagt ctgtggcagt 540 ttcagaagag gtgcagagtc cagtggtgac atggatgttc tcctgaccca tcccagcttc 600 acttcagaat caaccaaaca gccaaaactg ttacatcagg ttgtggagca gttacaaaag 660 gttcatttta tcacagatac cctgtcaaag ggtgagacaa agttcatggg tgtttgccag 720 cttcccagta aaaatgatga aaaagaatat ccacacagaa gaattgatat caggttgata 780 cccaaagatc agtattactg tggtgttctc tatttcactg ggagtgatat tttcaataag 840 aatatgaggg ctcatgccct agaaaagggt ttcacaatca atgagtacac catccgtccc 900 ttgggagtca ctggagttgc aggagaaccc ctgccagtgg atagtgaaaa agacatcttt 960 gattacatcc agtggaaata ccgggaaccc aaggaccgga gcgaatga 1008 <210> 488 <211> 1259 <212> DNA <213> Homo sapiens <400> 488 ccggagctgg gttgctcctg ctcccgtctc caagtcctgg tacctccttc aagctgggag 60 agggctctag tccctggttc tgaacactct ggggttctcg ggtgcaggcc gccatgagca 120 aacggaaggc gccgcaggag actctcaacg ggggaatcac cgacatgctc acagaactcg 180 caaactttga gaagaacgtg agccaagcta tccacaagta caatgcttac agaaaagcag 240 catctgttat agcaaaatac ccacacaaaa taaagagtgg agctgaagct aagaaattgc 300 ctggagtagg aacaaaaatt gctgaaaaga ttgatgagtt tttagcaact ggaaaattac 360 gtaaactgga aaagattcgg caggatgata cgagttcatc catcaatttc ctgactcgag 420 ttagtggcat tggtccatct gctgcaagga agtttgtaga tgaaggaatt aaaacactag 480 aagatctcag aaaaaatgaa gataaattga accatcatca gcgaattggg ctgaaatatt 540 ttggggactt tgaaaaaaga attcctcgtg aagagatgtt acaaatgcaa gatattgttc 600 taaatgaagt taaaaaagtg gattctgaat acattgctac agtctgtggc agtttcagaa 660 gaggtgcaga gtccagtggt gacatggatg ttctcctgac ccatcccagc ttcacttcag 720 aatcaaccaa acagccaaaa ctgttacatc aggttgtgga gcagttacaa aaggttcatt 780 ttatcacaga tacccgttca aagggtgaga caaagttcat gggtgtttgc cagcttccca 840 gtaaaaatga tgaaaaagaa tatccacaca gaagaattga tatcaggtta tacccaaaag 900 atcagtatta ctgtggtgtt ctctatttca ctgggagtga tattttcaat aagaatatga 960 gagctcatgc caaggaaaag ggtttcacaa tcaatgagta caccatccgt cccttgggag 1020 tcactggagt tgcaggagaa cccctgccag tggatagtga aaaagacatc tttgattaca 1080 tccagtggaa ataccgggaa cccaaggacc ggagcgaatg aggcctgtat cctccctggc 1140 gcagacacaa cccaatgggt cttaatttat ttcttaacct ttgctatgta agggtctttg 1200 gtgtttttaa atgattgttt cttcttcatg cttttgcttg caatgtagtc aataaaacc 1259 <210> 489 <211> 3145 <212> DNA <213> Homo sapiens <400> 489 ggcgggaaac agcttagtgg gtgtggggtc gcgcattttc ttcaaccagg aggtgaggag 60 gtttcgacat ggcggtgcag ccgaaggaga cgctgcagtt ggagagcgcg gccgaggtcg 120 gcttcgtgcg cttctttcag ggcatgccgg agaagccgac caccacagtg cgccttttcg 180 accggggcga cttctatacg gcgcacggcg aggacgcgct gctggccgcc cgggaggtgt 240 tcaagaccca gggggtgatc aagtacatgg ggccggcagg agcaaagaat ctgcagagtg 300 ttgtgcttag taaaatgaat tttgaatctt ttgtaaaaga tcttcttctg gttcgtcagt 360 atagagttga agtttataag aatagagctg gaaataaggc atccaaggag aatgattggt 420 atttggcata taaggcttct cctggcaatc tctctcagtt tgaagacatt ctctttggta 480 acaatgatat gtcagcttcc attggtgttg tgggtgttaa aatgtccgca gttgatggcc 540 agagacaggt tggagttggg tatgtggatt ccatacagag gaaactagga ctgtgtgaat 600 tccctgataa tgatcagttc tccaatcttg aggctctcct catccagatt ggaccaaagg 660 aatgtgtttt acccggagga gagactgctg gagacatggg gaaactgaga cagataattc 720 aaagaggagg aattctgatc acagaaagaa aaaaagctga cttttccaca aaagacattt 780 atcaggacct caaccggttg ttgaaaggca aaaagggaga gcagatgaat agtgctgtat 840 tgccagaaat ggagaatcag gttgcagttt catcactgtc tgcggtaatc aagtttttag 900 aactcttatc agatgattcc aactttggac agtttgaact gactactttt gacttcagcc 960 agtatatgaa attggatatt gcagcagtca gagcccttaa cctttttcag ggttctgttg 1020 aagataccac tggctctcag tctctggctg ccttgctgaa taagtgtaaa acccctcaag 1080 gacaaagact tgttaaccag tggattaagc agcctctcat ggataagaac agaatagagg 1140 agagattgaa tttagtggaa gcttttgtag aagatgcaga attgaggcag actttacaag 1200 aagatttact tcgtcgattc ccagatctta accgacttgc caagaagttt caaagacaag 1260 cagcaaactt acaagattgt taccgactct atcagggtat aaatcaacta cctaatgtta 1320 tacaggctct ggaaaaacat gaaggaaaac accagaaatt attgttggca gtttttgtga 1380 ctcctcttac tgatcttcgt tctgacttct ccaagtttca ggaaatgata gaaacaactt 1440 tagatatgga tcaggtggaa aaccatgaat tccttgtaaa accttcattt gatcctaatc 1500 tcagtgaatt aagagaaata atgaatgact tggaaaagaa gatgcagtca acattaataa 1560 gtgcagccag agatcttggc ttggaccctg gcaaacagat taaactggat tccagtgcac 1620 agtttggata ttactttcgt gtaacctgta aggaagaaaa agtccttcgt aacaataaaa 1680 actttagtac tgtagatatc cagaagaatg gtgttaaatt taccaacagc aaattgactt 1740 ctttaaatga agagtatacc aaaaataaaa cagaatatga agaagcccag gatgccattg 1800 ttaaagaaat tgtcaatatt tcttcaggct atgtagaacc aatgcagaca ctcaatgatg 1860 tgttagctca gctagatgct gttgtcagct ttgctcacgt gtcaaatgga gcacctgttc 1920 catatgtacg accagccatt ttggagaaag gacaaggaag aattatatta aaagcatcca 1980 ggcatgcttg tgttgaagtt caagatgaaa ttgcatttat tcctaatgac gtatactttg 2040 aaaaagataa acagatgttc cacatcatta ctggccccaa tatgggaggt aaatcaacat 2100 atattcgaca aactggggtg atagtactca tggcccaaat tgggtgtttt gtgccatgtg 2160 agtcagcaga agtgtccatt gtggactgca tcttagcccg agtaggggct ggtgacagtc 2220 aattgaaagg agtctccacg ttcatggctg aaatgttgga aactgcttct atcctcaggt 2280 ctgcaaccaa agattcatta ataatcatag atgaattggg aagaggaact tctacctacg 2340 atggatttgg gttagcatgg gctatatcag aatacattgc aacaaagatt ggtgcttttt 2400 gcatgtttgc aacccatttt catgaactta ctgccttggc caatcagata ccaactgtta 2460 ataatctaca tgtcacagca ctcaccactg aagagacctt aactatgctt tatcaggtga 2520 agaaaggtgt ctgtgatcaa agttttggga ttcatgttgc agagcttgct aatttcccta 2580 agcatgtaat agagtgtgct aaacagaaag ccctggaact tgaggagttt cagtatattg 2640 gagaatcgca aggatatgat atcatggaac cagcagcaaa gaagtgctat ctggaaagag 2700 agcaaggtga aaaaattatt caggagttcc tgtccaaggt gaaacaaatg ccctttactg 2760 aaatgtcaga agaaaacatc acaataaagt taaaacagct aaaagctgaa gtaatagcaa 2820 agaataatag ctttgtaaat gaaatcattt cacgaataaa agttactacg tgaaaaatcc 2880 cagtaatgga atgaaggtaa tattgataag ctattgtctg taatagtttt atattgtttt 2940 atattaaccc tttttccata gtgttaactg tcagtgccca tgggctatca acttaataag 3000 atatttagta atattttact ttgaggacat tttcaaagat ttttattttg aaaaatgaga 3060 gctgtaactg aggactgttt gcaattgaca taggcaataa taagtgatgt gctgaatttt 3120 ataaataaaa tcatgtagtt tgtgg 3145 <210> 490 <211> 3116 <212> DNA <213> Homo sapiens <400> 490 gaggaggttt cgacatggcg gtgcagccga aggagacgct gcagttggag agcgcggccg 60 aggtcggctt cgtgcgcttc tttcagggca tgccggagaa gccgaccacc acagtgcgcc 120 ttttcgaccg gggcgacttc tatacggcgc acggcgagga cgcgctgctg gccgcccggg 180 aggtgttcaa gacccagggg gtgatcaagt acatggggcc ggcaggagca aagaatctgc 240 agagtgttgt gcttagtaaa atgaattttg aatcttttgt aaaagatctt cttctggttc 300 gtcagtatag agttgaagtt tataagaata gagctggaaa taaggcatcc aaggagaatg 360 attggtattt ggcatataag gcttctcctg gcaatctctc tcagtttgaa gacattctct 420 ttggtaacaa tgatatgtca gcttccattg gtgttgtggg tgttaaaatg tccgcagttg 480 atggccagag acaggttgga gttgggtatg tggattccat acagaggaaa ctaggactgt 540 gtgaattccc tgataatgat cagttctcca atcttgaggc tctcctcatc cagattggac 600 caaaggaatg tgttttaccc ggaggagaga ctgctggaga catggggaaa ctgagacaga 660 taattcaaag aggaggaatt ctgatcacag aaagaaaaaa agctgacttt tccacaaaag 720 acatttatca ggacctcaac cggttgttga aaggcaaaaa gggagagcag atgaatagtg 780 ctgtattgcc agaaatggag aatcaggttg cagtttcatc actgtctgcg gtaatcaagt 840 ttttagaact cttatcagat gattccaact ttggacagtt tgaactgact acttttgact 900 tcagccagta tatgaaattg gatattgcag cagtcagagc ccttaacctt tttcagggtt 960 ctgttgaaga taccactggc tctcagtctc tggctgcctt gctgaataag tgtaaaaccc 1020 ctcaaggaca aagacttgtt aaccagtgga ttaagcagcc tctcatggat aagaacagaa 1080 tagaggagag attgaattta gtggaagctt ttgtagaaga tgcagaattg aggcagactt 1140 tacaagaaga tttacttcgt cgattcccag atcttaaccg acttgccaag aagtttcaaa 1200 gacaagcagc aaacttacaa gattgttacc gactctatca gggtataaat caactaccta 1260 atgttataca ggctctggaa aaacatgaag gaaaacacca gaaattattg ttggcagttt 1320 ttgtgactcc tcttactgat cttcgttctg acttctccaa gtttcaggaa atgatagaaa 1380 caactttaga tatggatcag gtggaaaacc atgaattcct tgtaaaacct tcatttgatc 1440 ctaatctcag tgaattaaga gaaataatga atgacttgga aaagaagatg cagtcaacat 1500 taataagtgc agccagagat cttggcttgg accctggcaa acagattaaa ctggattcca 1560 gtgcacagtt tggatattac tttcgtgtaa cctgtaagga agaaaaagtc cttcgtaaca 1620 ataaaaactt tagtactgta gatatccaga agaatggtgt taaatttacc aacagcaaat 1680 tgacttcttt aaatgaagag tataccaaaa ataaaacaga atatgaagaa gcccaggatg 1740 ccattgttaa agaaattgtc aatatttctt caggctatgt agaaccaatg cagacactca 1800 atgatgtgtt agctcagcta gatgctgttg tcagctttgc tcacgtgtca aatggagcac 1860 ctgttccata tgtacgacca gccattttgg agaaaggaca aggaagaatt atattaaaag 1920 catccaggca tgcttgtgtt gaagttcaag atgaaattgc atttattcct aatgacgtat 1980 actttgaaaa agataaacag atgttccaca tcattactgg ccccaatatg ggaggtaaat 2040 caacatatat tcgacaaact ggggtgatag tactcatggc ccaaattggg tgttttgtgc 2100 catgtgagtc agcagaagtg tccattgtgg actgcatctt agcccgagta ggggctggtg 2160 acagtcaatt gaaaggagtc tccacgttca tggctgaaat gttggaaact gcttctatcc 2220 tcaggtctgc aaccaaagat tcattaataa tcatagatga attgggaaga ggaacttcta 2280 cctacgatgg atttgggtta gcatgggcta tatcagaata cattgcaaca aagattggtg 2340 ctttttgcat gtttgcaacc cattttcatg aacttactgc cttggccaat cagataccaa 2400 ctgttaataa tctacatgtc acagcactca ccactgaaga gaccttaact atgctttatc 2460 aggtgaagaa aggtgtctgt gatcaaagtt ttgggattca tgttgcagag cttgctaatt 2520 tccctaagca tgtaatagag tgtgctaaac agaaagccct ggaacttgag gagtttcagt 2580 atattggaga atcgcaagga tatgatatca tggaaccagc agcaaagaag tgctatctgg 2640 aaagagagca aggtgaaaaa attattcagg agttcctgtc caaggtgaaa caaatgccct 2700 ttactgaaat gtcagaagaa aacatcacaa taaagttaaa acagctaaaa gctgaagtaa 2760 tagcaaagaa taatagcttt gtaaatgaaa tcatttcacg aataaaagtt actacgtgaa 2820 aaatcccagt aatggaatga aggtaatatt gataagctat tgtctgtaat agttttatat 2880 tgttttatat taaccctttt tccatagtgt taactgtcag tgcccatggg ctatcaactt 2940 aataagatat ttagtaatat tttactttga ggacattttc aaagattttt attttgaaaa 3000 atgagagctg taactgagga ctgtttgcaa ttgacatagg caataataag tgatgtgctg 3060 aattttataa ataaaatcat gtagtttgtg gaaaaaaaaa aaaaaaaaaa aaaaaa 3116 <210> 491 <211> 2919 <212> DNA <213> Homo sapiens <400> 491 tcgcgcattt tcttcaacca ggaggtgagg aggtttcgac atggcggtgc agccgaagga 60 gacgctgcag ttggagagcg cggccgaggt cggcttcgtg cgcttctttc agggcatgcc 120 ggagaagccg accaccacag tgcgcctttt cgaccggggc gacttctata cggcgcacgg 180 cgaggacgcg ctgctggccg cccgggaggt gttcaagacc cagggggtga tcaagtacat 240 ggggccggca ggagcaaaga atctgcagag tgttgtgctt agtaaaatga attttgaatc 300 ttttgtaaaa gatcttcttc tggttcgtca gtatagagtt gaagtttata agaatagagc 360 tggaaataag gcatccaagg agaatgattg gtatttggca tataaggctt ctcctggcaa 420 tctctctcag tttgaagaca ttctctttgg taacaatgat atgtcagctt ccattggtgt 480 tgtgggtgtt aaaatgtccg cagttgatgg ccagagacag gttggagttg ggtatgtgga 540 ttccatacag aggaaactag gactgtgtga attccctgat aatgatcagt tctccaatct 600 tgaggctctc ctcatccaga ttggaccaaa ggaatgtgtt ttacccggag gagagactgc 660 tggagacatg gggaaactga gacagataat tcaaagagga ggaattctga tcacagaaag 720 aaaaaaagct gacttttcca caaaagacat ttatcaggac ctcaaccggt tgttgaaagg 780 caaaaaggga gagcagatga atagtgctgt attgccagaa atggagaatc aggttgcagt 840 ttcatcactg tctgcggtaa tcaagttttt agaactctta tcagatgatt ccaactttgg 900 acagtttgaa ctgactactt ttgacttcag ccagtatatg aaattggata ttgcagcagt 960 cagagccctt aacctttttc agggttctgt tgaagatacc actggctctc agtctctggc 1020 tgccttgctg aataagtgta aaacccctca aggacaaaga cttgttaacc agtggattaa 1080 gcagcctctc atggataaga acagaataga ggagagattg aatttagtgg aagcttttgt 1140 agaagatgca gaattgaggc agactttaca agaagattta cttcgtcgat tcccagatct 1200 taaccgactt gccaagaagt ttcaaagaca agcagcaaac ttacaagatt gttaccgact 1260 ctatcagggt ataaatcaac tacctaatgt tatacaggct ctggaaaaac atgaaggaaa 1320 acaccagaaa ttattgttgg cagtttttgt gactcctctt actgatcttc gttctgactt 1380 ctccaagttt caggaaatga tagaaacaac tttagatatg gatcaggtgg aaaaccatga 1440 attccttgta aaaccttcat ttgatcctaa tctcagtgaa ttaagagaaa taatgaatga 1500 cttggaaaag aagatgcagt caacattaat aagtgcagcc agagatcttg gcttggaccc 1560 tggcaaacag attaaactgg attccagtgc acagtttgga tattactttc gtgtaacctg 1620 taaggaagaa aaagtccttc gtaacaataa aaactttagt actgtagata tccagaagaa 1680 tggtgttaaa tttaccaaca gcaaattgac ttctttaaat gaagagtata ccaaaaataa 1740 aacagaatat gaagaagccc aggatgccat tgttaaagaa attgtcaata tttcttcagg 1800 ctatgtagaa ccaatgcaga cactcaatga tgtgttagct cagctagatg ctgttgtcag 1860 ctttgctcac gtgtcaaatg gagcacctgt tccatatgta cgaccagcca ttttggagaa 1920 aggacaagga agaattatat taaaagcatc caggcatgct tgtgttgaag ttcaagatga 1980 aattgcattt attcctaatg acgtatactt tgaaaaagat aaacagatgt tccacatcat 2040 tactggcccc aatatgggag gtaaatcaac atatattcga caaactgggg tgatagtact 2100 catggcccaa attgggtgtt ttgtgccatg tgagtcagca gaagtgtcca ttgtggactg 2160 catcttagcc cgagtagggg ctggtgacag tcaattgaaa ggagtctcca cgttcatggc 2220 tgaaatgttg gaaactgctt ctatcctcag gtctgcaacc aaagattcat taataatcat 2280 agatgaattg ggaagaggaa cttctaccta cgatggattt gggttagcat gggctatatc 2340 agaatacatt gcaacaaaga ttggtgcttt ttgcatgttt gcaacccatt ttcatgaact 2400 tactgccttg gccaatcaga taccaactgt taataatcta catgtcacag cactcaccac 2460 tgaagagacc ttaactatgc tttatcaggt gaagaaaggt gtctgtgatc aaagttttgg 2520 gattcatgtt gcagagcttg ctaatttccc taagcatgta atagagtgtg ctaaacagaa 2580 agccctggaa cttgaggagt ttcagtatat tggagaatcg caaggatatg atatcatgga 2640 accagcagca aagaagtgct atctggaaag agagcaaggt gaaaaaatta ttcaggagtt 2700 cctgtccaag gtgaaacaaa tgccctttac tgaaatgtca gaagaaaaca tcacaataaa 2760 gttaaaacag ctaaaagctg aagtaatagc aaagaataat agctttgtaa atgaaatcat 2820 ttcacgaata aaagttacta cgtgaaaaat cccagtaatg gaatgaaggt aatattgata 2880 agctattgtc tgtaatagtt ttatattgtt ttatattaa 2919 <210> 492 <211> 2947 <212> DNA <213> Homo sapiens <400> 492 ggcgggaaac agcttagtgg gtgtggggtc gcgcattttc ttcaaccagg aggtgaggag 60 gtttcgacat ggcggtgcag ccgaaggaga cgctgcagtt ggagagcgcg gccgaggtcg 120 gcttcgtgcg cttctttcag ggcatgccgg agaagccgac caccacagtg cgccttttcg 180 accggggcga cttctatacg gcgcacggcg aggacgcgct gctggccgcc cgggaggtgt 240 tcaagaccca gggggtgatc aagtacatgg ggccggcagg agcaaagaat ctgcagagtg 300 ttgtgcttag taaaatgaat tttgaatctt ttgtaaaaga tcttcttctg gttcgtcagt 360 atagagttga agtttataag aatagagctg gaaataaggc atccaaggag aatgattggt 420 atttggcata taaggcttct cctggcaatc tctctcagtt tgaagacatt ctctttggta 480 acaatgatat gtcagcttcc attggtgttg tgggtgttaa aatgtccgca gttgatggcc 540 agagacaggt tggagttggg tatgtggatt ccatacagag gaaactagga ctgtgtgaat 600 tccctgataa tgatcagttc tccaatcttg aggctctcct catccagatt ggaccaaagg 660 aatgtgtttt acccggagga gagactgctg gagacatggg gaaactgaga cagataattc 720 aaagaggagg aattctgatc acagaaagaa aaaaagctga cttttccaca aaagacattt 780 atcaggacct caaccggttg ttgaaaggca aaaagggaga gcagatgaat agtgctgtat 840 tgccagaaat ggagaatcag gttgcagttt catcactgtc tgcggtaatc aagtttttag 900 aactcttatc agatgattcc aactttggac agtttgaact gactactttt gacttcagcc 960 agtatatgaa attggatatt gcagcagtca gagcccttaa cctttttcag ggttctgttg 1020 aagataccac tggctctcag tctctggctg ccttgctgaa taagtgtaaa acccctcaag 1080 gacaaagact tgttaaccag tggattaagc agcctctcat ggataagaac agaatagagg 1140 agagattgaa tttagtggaa gcttttgtag aagatgcaga attgaggcag actttacaag 1200 aagatttact tcgtcgattc ccagatctta accgacttgc caagaagttt caaagacaag 1260 cagcaaactt acaagattgt taccgactct atcagggtat aaatcaacta cctaatgtta 1320 tacaggctct ggaaaaacat gaaggaaaac accagaaatt attgttggca gtttttgtga 1380 ctcctcttac tgatcttcgt tctgacttct ccaagtttca ggaaatgata gaaacaactt 1440 tagatatgga tcaggtggaa aaccatgaat tccttgtaaa accttcattt gatcctaatc 1500 tcagtgaatt aagagaaata atgaatgact tggaaaagaa gatgcagtca acattaataa 1560 gtgcagccag agatcttggc ttggaccctg gcaaacagat taaactggat tccagtgcac 1620 agtttggata ttactttcgt gtaacctgta aggaagaaaa agtccttcgt aacaataaaa 1680 actttagtac tgtagatatc cagaagaatg gtgttaaatt taccaacagc aaattgactt 1740 ctttaaatga agagtatacc aaaaataaaa cagaatatga agaagcccag gatgccattg 1800 ttaaagaaat tgtcaatatt tcttcaggct atgtagaacc aatgcagaca ctcaatgatg 1860 tgttagctca gctagatgct gttgtcagct ttgctcacgt gtcaaatgga gcacctgttc 1920 catatgtacg accagccatt ttggagaaag gacaaggaag aattatatta aaagcatcca 1980 ggcatgcttg tgttgaagtt caagatgaaa ttgcatttat tcctaatgac gtatactttg 2040 aaaaagataa acagatgttc cacatcatta ctggccccaa tatgggaggt aaatcaacat 2100 atattcgaca aactggggtg atagtactca tggcccaaat tgggtgtttt gtgccatgtg 2160 agtcagcaga agtgtccatt gtggactgca tcttagcccg agtaggggct ggtgacagtc 2220 aattgaaagg agtctccacg ttcatggctg aaatgttgga aactgcttct atcctcaggt 2280 ctgcaaccaa agattcatta ataatcatag atgaattggg aagaggaact tctacctacg 2340 atggatttgg gttagcatgg gctatatcag aatacattgc aacaaagatt ggtgcttttt 2400 gcatgtttgc aacccatttt catgaactta ctgccttggc caatcagata ccaactgtta 2460 ataatctaca tgtcacagca ctcaccactg aagagacctt aactatgctt tatcaggtga 2520 agaaaggtgt ctgtgatcaa agttttggga ttcatgttgc agagcttgct aatttcccta 2580 agcatgtaat agagtgtgct aaacagaaag ccctggaact tgaggagttt cagtatattg 2640 gagaatcgca aggatatgat atcatggaac cagcagcaaa gaagtgctat ctggaaagag 2700 agcaaggtga aaaaattatt caggagttcc tgtccaaggt gaaacaaatg ccctttactg 2760 aaatgtcaga agaaaacatc acaataaagt taaaacagct aaaagctgaa gtaatagcaa 2820 agaataatag ctttgtaaat gaaatcattt cacgaataaa agttactacg tgaaaaatcc 2880 cagtaatgga atgaaggtaa tattgataag ctattgtctg taatagtttt atattgtttt 2940 atattaa 2947 <210> 493 <211> 2919 <212> DNA <213> Homo sapiens <400> 493 tcgcgcattt tcttcaacca ggaggtgagg aggtttcgac atggcggtgc agccgaagga 60 gacgctgcag ttggagagcg cggccgaggt cggcttcgtg cgcttctttc agggcatgcc 120 ggagaagccg accaccacag tgcgcctttt cgaccggggc gacttctata cggcgcacgg 180 cgaggacgcg ctgctggccg cccgggaggt gttcaagacc cagggggtga tcaagtacat 240 ggggccggca ggagcaaaga atctgcagag tgttgtgctt agtaaaatga attttgaatc 300 ttttgtaaaa gatcttcttc tggttcgtca gtatagagtt gaagtttata agaatagagc 360 tggaaataag gcatccaagg agaatgattg gtatttggca tataaggctt ctcctggcaa 420 tctctctcag tttgaagaca ttctctttgg taacaatgat atgtcagctt ccattggtgt 480 tgtgggtgtt aaaatgtccg cagttgatgg ccagagacag gttggagttg ggtatgtgga 540 ttccatacag aggaaactag gactgtgtga attccctgat aatgatcagt tctccaatct 600 tgaggctctc ctcatccaga ttggaccaaa ggaatgtgtt ttacccggag gagagactgc 660 tggagacatg gggaaactga gacagataat tcaaagagga ggaattctga tcacagaaag 720 aaaaaaagct gacttttcca caaaagacat ttatcaggac ctcaaccggt tgttgaaagg 780 caaaaaggga gagcagatga atagtgctgt attgccagaa atggagaatc aggttgcagt 840 ttcatcactg tctgcggtaa tcaagttttt agaactctta tcagatgatt ccaactttgg 900 acagtttgaa ctgactactt ttgacttcag ccagtatatg aaattggata ttgcagcagt 960 cagagccctt aacctttttc agggttctgt tgaagatacc actggctctc agtctctggc 1020 tgccttgctg aataagtgta aaacccctca aggacaaaga cttgttaacc agtggattaa 1080 gcagcctctc atggataaga acagaataga ggagagattg aatttagtgg aagcttttgt 1140 agaagatgca gaattgaggc agactttaca agaagattta cttcgtcgat tcccagatct 1200 taaccgactt gccaagaagt ttcaaagaca agcagcaaac ttacaagatt gttaccgact 1260 ctatcagggt ataaatcaac tacctaatgt tatacaggct ctggaaaaac atgaaggaaa 1320 acactagaaa ttattgttgg cagtttttgt gactcctctt actgatcttc gttctgactt 1380 ctccaagttt caggaaatga tagaaacaac tttagatatg gatcaggtgg aaaaccatga 1440 attccttgta aaaccttcat ttgatcctaa tctcagtgaa ttaagagaaa taatgaatga 1500 cttggaaaag aagatgcagt caacattaat aagtgcagcc agagatcttg gcttggaccc 1560 tggcaaacag attaaactgg attccagtgc acagtttgga tattactttc gtgtaacctg 1620 taaggaagaa aaagtccttc gtaacaataa aaactttagt actgtagata tccagaagaa 1680 tggtgttaaa tttaccaaca gcaaattgac ttctttaaat gaagagtata ccaaaaataa 1740 aacagaatat gaagaagccc aggatgccat tgttaaagaa attgtcaata tttcttcagg 1800 ctatgtagaa ccaatgcaga cactcaatga tgtgttagct cagctagatg ctgttgtcag 1860 ctttgctcac gtgtcaaatg gagcacctgt tccatatgta cgaccagcca ttttggagaa 1920 aggacaagga agaattatat taaaagcatc caggcatgct tgtgttgaag ttcaagatga 1980 aattgcattt attcctaatg acgtatactt tgaaaaagat aaacagatgt tccacatcat 2040 tactggcccc aatatgggag gtaaatcaac atatattcga caaactgggg tgatagtact 2100 catggcccaa attgggtgtt ttgtgccatg tgagtcagca gaagtgtcca ttgtggactg 2160 catcttagcc cgagtagggg ctggtgacag tcaattgaaa ggagtctcca cgttcatggc 2220 tgaaatgttg gaaactgctt ctatcctcag gtctgcaacc aaagattcat taataatcat 2280 agatgaattg ggaagaggaa cttctaccta cgatggattt gggttagcat gggctatatc 2340 agaatacatt gcaacaaaga ttggtgcttt ttgcatgttt gcaacccatt ttcatgaact 2400 tactgccttg gccaatcaga taccaactgt taataatcta catgtcacag cactcaccac 2460 tgaagagacc ttaactatgc tttatcaggt gaagaaaggt gtctgtgatc aaagttttgg 2520 gattcatgtt gcagagcttg ctaatttccc taagcatgta atagagtgtg ctaaacagaa 2580 agccctggaa cttgaggagt ttcagtatat tggagaatcg caaggatatg atatcatgga 2640 accagcagca aagaagtgct atctggaaag agagcaaggt gaaaaaatta ttcaggagtt 2700 cctgtccaag gtgaaacaaa tgccctttac tgaaatgtca gaagaaaaca tcacaataaa 2760 gttaaaacag ctaaaagctg aagtaatagc aaagaataat agctttgtaa atgaaatcat 2820 ttcacgaata aaagttacta cgtgaaaaat cccagtaatg gaatgaaggt aatattgata 2880 agctattgtc tgtaatagtt ttatattgtt ttatattaa 2919 <210> 494 <211> 2919 <212> DNA <213> Homo sapiens <400> 494 tcgcgcattt tcttcaacca ggaggtgagg aggtttcgac atggcggtgc agccgaagga 60 gacgctgcag ttggagagcg cggccgaggt cggcttcgtg cgcttctttc agggcatgcc 120 ggagaagccg accaccacag tgcgcctttt cgaccggggc gacttctata cggcgcacgg 180 cgaggacgcg ctgctggccg cccgggaggt gttcaagacc cagggggtga tcaagtacat 240 ggggccggca ggagcaaaga atctgcagag tgttgtgctt agtaaaatga attttgaatc 300 ttttgtaaaa gatcttcttc tggttcgtca gtatagagtt gaagtttata agaatagagc 360 tggaaataag gcatccaagg agaatgattg gtatttggca tataaggctt ctcctggcaa 420 tctctctcag tttgaagaca ttctctttgg taacaatgat atgtcagctt ccattggtgt 480 tgtgggtgtt aaaatgtccg cagttgatgg ccagagacag gttggagttg ggtatgtgga 540 ttccatacag aggaaactag gactgtgtga attccctgat aatgatcagt tctccaatct 600 tgaggctctc ctcatccaga ttggaccaaa ggaatgtgtt ttacccggag gagagactgc 660 tggagacatg gggaaactga gacagataat tcaaagagga ggaattctga tcacagaaag 720 aaaaaaagct gacttttcca caaaagacat ttatcaggac ctcaaccggt tgttgaaagg 780 caaaaaggga gagcagatga atagtgctgt attgccagaa atggagaatc aggttgcagt 840 ttcatcactg tctgcggtaa tcaagttttt agaactctta tcagatgatt ccaactttgg 900 atagtttgaa ctgactactt ttgacttcag ccagtatatg aaattggata ttgcagcagt 960 cagagccctt aacctttttc agggttctgt tgaagatacc actggctctc agtctctggc 1020 tgccttgctg aataagtgta aaacccctca aggacaaaga cttgttaacc agtggattaa 1080 gcagcctctc atggataaga acagaataga ggagagattg aatttagtgg aagcttttgt 1140 agaagatgca gaattgaggc agactttaca agaagattta cttcgtcgat tcccagatct 1200 taaccgactt gccaagaagt ttcaaagaca agcagcaaac ttacaagatt gttaccgact 1260 ctatcagggt ataaatcaac tacctaatgt tatacaggct ctggaaaaac atgaaggaaa 1320 acaccagaaa ttattgttgg cagtttttgt gactcctctt actgatcttc gttctgactt 1380 ctccaagttt caggaaatga tagaaacaac tttagatatg gatcaggtgg aaaaccatga 1440 attccttgta aaaccttcat ttgatcctaa tctcagtgaa ttaagagaaa taatgaatga 1500 cttggaaaag aagatgcagt caacattaat aagtgcagcc agagatcttg gcttggaccc 1560 tggcaaacag attaaactgg attccagtgc acagtttgga tattactttc gtgtaacctg 1620 taaggaagaa aaagtccttc gtaacaataa aaactttagt actgtagata tccagaagaa 1680 tggtgttaaa tttaccaaca gcaaattgac ttctttaaat gaagagtata ccaaaaataa 1740 aacagaatat gaagaagccc aggatgccat tgttaaagaa attgtcaata tttcttcagg 1800 ctatgtagaa ccaatgcaga cactcaatga tgtgttagct cagctagatg ctgttgtcag 1860 ctttgctcac gtgtcaaatg gagcacctgt tccatatgta cgaccagcca ttttggagaa 1920 aggacaagga agaattatat taaaagcatc caggcatgct tgtgttgaag ttcaagatga 1980 aattgcattt attcctaatg acgtatactt tgaaaaagat aaacagatgt tccacatcat 2040 tactggcccc aatatgggag gtaaatcaac atatattcga caaactgggg tgatagtact 2100 catggcccaa attgggtgtt ttgtgccatg tgagtcagca gaagtgtcca ttgtggactg 2160 catcttagcc cgagtagggg ctggtgacag tcaattgaaa ggagtctcca cgttcatggc 2220 tgaaatgttg gaaactgctt ctatcctcag gtctgcaacc aaagattcat taataatcat 2280 agatgaattg ggaagaggaa cttctaccta cgatggattt gggttagcat gggctatatc 2340 agaatacatt gcaacaaaga ttggtgcttt ttgcatgttt gcaacccatt ttcatgaact 2400 tactgccttg gccaatcaga taccaactgt taataatcta catgtcacag cactcaccac 2460 tgaagagacc ttaactatgc tttatcaggt gaagaaaggt gtctgtgatc aaagttttgg 2520 gattcatgtt gcagagcttg ctaatttccc taagcatgta atagagtgtg ctaaacagaa 2580 agccctggaa cttgaggagt ttcagtatat tggagaatcg caaggatatg atatcatgga 2640 accagcagca aagaagtgct atctggaaag agagcaaggt gaaaaaatta ttcaggagtt 2700 cctgtccaag gtgaaacaaa tgccctttac tgaaatgtca gaagaaaaca tcacaataaa 2760 gttaaaacag ctaaaagctg aagtaatagc aaagaataat agctttgtaa atgaaatcat 2820 ttcacgaata aaagttacta cgtgaaaaat cccagtaatg gaatgaaggt aatattgata 2880 agctattgtc tgtaatagtt ttatattgtt ttatattaa 2919 <210> 495 <211> 2919 <212> DNA <213> Homo sapiens <400> 495 tcgcgcattt tcttcaacca ggaggtgagg aggtttcgac atggcggtgc agccgaagga 60 gacgctgcag ttggagagcg cggccgaggt cggcttcgtg cgcttctttc agggcatgcc 120 ggagaagccg accaccacag tgcgcctttt cgaccggggc gacttctata cggcgcacgg 180 cgaggacgcg ctgctggccg cccgggaggt gttcaagacc cagggggtga tcaagtacat 240 ggggccggca ggagcaaaga atctgcagag tgttgtgctt agtaaaatga attttgaatc 300 ttttgtaaaa gatcttcttc tggttcgtca gtatagagtt gaagtttata agaatagagc 360 tggaaataag gcatccaagg agaatgattg gtatttggca tataaggctt ctcctggcaa 420 tctctctcag tttgaagaca ttctctttgg taacaatgat atgtcagctt ccattggtgt 480 tgtgggtgtt aaaatgtccg cagttgatgg ccagagacag gttggagttg ggtatgtgga 540 ttccatacag aggaaactag gactgtgtga attccctgat aatgatcagt tctccaatct 600 tgaggctctc ctcatccaga ttggaccaaa ggaatgtgtt ttacccggag gagagactgc 660 tggagacatg gggaaactga gacagataat tcaaagagga ggaattctga tcacagaaag 720 aaaaaaagct gacttttcca caaaagacat ttatcaggac ctcaaccggt tgttgaaagg 780 caaaaaggga gagcagatga atagtgctgt attgccagaa atggagaatc aggttgcagt 840 ttcatcactg tctgcggtaa tcaagttttt agaactctta tcagatgatt ccaactttgg 900 acagtttgaa ctgactactt ttgacttcag ccagtatatg aaattggata ttgcagcagt 960 cagagccctt aacctttttc agggttctgt tgaagatacc actggctctc agtctctggc 1020 tgccttgctg aataagtgta aaacccctca aggacaaaga cttgttaacc agtggattaa 1080 gcagcctctc atggataaga acagaataga ggagagattg aatttagtgg aagcttttgt 1140 agaagatgca gaattgaggc agactttaca agaagattta cttcgtcgat tcccagatct 1200 taaccgactt gccaagaagt ttcaaagaca agcagcaaac ttacaagatt gttaccgact 1260 ctatcagggt ataaatcaac tacctaatgt tatacaggct ctggaaaaac atgaaggaaa 1320 acaccagaaa ttattgttgg cagtttttgt gactcctctt actgatcttc gttctgactt 1380 ctccaagttt caggaaatga tagaaacaac tttagatatg gatcaggtgg aaaaccatga 1440 attccttgta aaaccttcat ttgatcctaa tctcagtgaa ttaagagaaa taatgaatga 1500 cttggaaaag aagatgcagt caacattaat aagtgcagcc agagatcttg gcttggaccc 1560 tggcaaacag attaaactgg attccagtgc acagtttgga tattactttc gtgtaacctg 1620 taaggaagaa aaagtccttc gtaacaataa aaactttagt actgtagata tccagaagaa 1680 tggtgttaaa tttaccaaca gcaaactgac ttctttaaat gaagagtata ccaaaaataa 1740 aacagaatat gaagaagccc aggatgccat tgttaaagaa attgtcaata tttcttcagg 1800 ctatgtagaa ccaatgcaga cactcaatga tgtgttagct cagctagatg ctgttgtcag 1860 ctttgctcac gtgtcaaatg gagcacctgt tccatatgta cgaccagcca ttttggagaa 1920 aggacaagga agaattatat taaaagcatc caggcatgct tgtgttgaag ttcaagatga 1980 aattgcattt attcctaatg acgtatactt tgaaaaagat aaacagatgt tccacatcat 2040 tactggcccc aatatgggag gtaaatcaac atatattcga caaactgggg tgatagtact 2100 catggcccaa attgggtgtt ttgtgccatg tgagtcagca gaagtgtcca ttgtggactg 2160 catcttagcc cgagtagggg ctggtgacag tcaattgaaa ggagtctcca cgttcatggc 2220 tgaaatgttg gaaactgctt ctatcctcag gtctgcaacc aaagattcat taataatcat 2280 agatgaattg ggaagaggaa cttctaccta cgatggattt gggttagcat gggctatatc 2340 agaatacatt gcaacaaaga ttggtgcttt ttgcatgttt gcaacccatt ttcatgaact 2400 tactgccttg gccaatcaga taccaactgt taataatcta catgtcacag cactcaccac 2460 tgaagagacc ttaactatgc tttatcaggt gaagaaaggt gtctgtgatc aaagttttgg 2520 gattcatgtt gcagagcttg ctaatttccc taagcatgta atagagtgtg ctaaacagaa 2580 agccctggaa cttgaggagt ttcagtatat tggagaatcg caaggatatg atatcatgga 2640 accagcagca aagaagtgct atctggaaag agagcaaggt gaaaaaatta ttcaggagtt 2700 cctgtccaag gtgaaacaaa tgccctttac tgaaatgtca gaagaaaaca tcacaataaa 2760 gttaaaacag ctaaaagctg aagtaatagc aaagaataat agctttgtaa atgaaatcat 2820 ttcacgaata aaagttacta cgtgaaaaat cccagtaatg gaatgaaggt aatattgata 2880 agctattgtc tgtaatagtt ttatattgtt ttatattaa 2919 <210> 496 <211> 2919 <212> DNA <213> Homo sapiens <400> 496 tcgcgcattt tcttcaacca ggaggtgagg aggtttcgac atggcggtgc agccgaagga 60 gacgctgcag ttggagagcg cggccgaggt cggcttcgtg cgcttctttc agggcatgcc 120 ggagaagccg accaccacag tgcgcctttt cgaccggggc gacttctata cggcgcacgg 180 cgaggacgcg ctgctggccg cccgggaggt gttcaagacc cagggggtga tcaagtacat 240 ggggccggca ggagcaaaga atctgcagag tgttgtgctt agtaaaatga attttgaatc 300 ttttgtaaaa gatcttcttc tggttcgtca gtatagagtt gaagtttata agaatagagc 360 tggaaataag gcatccaagg agaatgattg gtatttggca tataaggctt ctcctggcaa 420 tctctctcag tttgaagaca ttctctttgg taacaatgat atgtcagctt ccattggtgt 480 tgtgggtgtt aaaatgtccg cagttgatgg ccagagacag gttggagttg ggtatgtgga 540 ttccatacag aggaaactag gactgtgtga attccctgat aatgatcagt tctccaatct 600 tgaggctctc ctcatccaga ttggaccaaa ggaatgtgtt ttacccggag gagagactgc 660 tggagacatg gggaaactga gacagataat tcaaagagga ggaattctga tcacagaaag 720 aaaaaaagct gacttttcca caaaagacat ttatcaggac ctcaaccggt tgttgaaagg 780 caaaaaggga gagcagatga atagtgctgt attgccagaa atggagaatc aggttgcagt 840 ttcatcactg tctgcggtaa tcaagttttt agaactctta tcagatgatt ccaactttgg 900 acagtttgaa ctgactactt ttgacttcag ccagtatatg aaattggata ttgcagcagt 960 cagagccctt aacctttttc agggttctgt tgaagatacc actggctctc agtctctggc 1020 tgccttgctg aataagtgta aaacccctca aggacaaaga cttgttaacc agtggattaa 1080 gcagcctctc atggataaga acagaataga ggagagattg aatttagtgg aagcttttgt 1140 agaagatgca gaattgaggc agactttaca agaagattta cttcgtcgat tcccagatct 1200 taaccgactt gccaagaagt ttcaaagaca agcagcaaac ttacaagatt gttaccgact 1260 ctatcagggt ataaatcaac tacctaatgt tatacaggct ctggaaaaac atgaaggaaa 1320 acaccagaaa ttattgttgg cagtttttgt gactcctctt actgatcttc gttctgactt 1380 ctccaagttt caggaaatga tagaaacaac tttagatatg gatcaggtgg aaaaccatga 1440 attccttgta aaaccttcat ttgatcctaa tctcagtgaa ttaagagaaa taatgaatga 1500 cttggaaaag aagatgcagt caacattaat aagtgcagcc agagatcttg gcttggaccc 1560 tggcaaacag attaaactgg attccagtgc acagtttgga tattactttc gtgtaacctg 1620 taaggaagaa aaagtccttc gtaacaataa aaactttagt actgtagata tccagaagaa 1680 tggtgttaaa tttaccaaca gcaaattgac ttctttaaat gaagagtata ccaaaaataa 1740 aacagaatat gaagaagccc aggatgccat tgttaaggaa attgtcaata tttcttcagg 1800 ctatgtagaa ccaatgcaga cactcaatga tgtgttagct cagctagatg ctgttgtcag 1860 ctttgctcac gtgtcaaatg gagcacctgt tccatatgta cgaccagcca ttttggagaa 1920 aggacaagga agaattatat taaaagcatc caggcatgct tgtgttgaag ttcaagatga 1980 aattgcattt attcctaatg acgtatactt tgaaaaagat aaacagatgt tccacatcat 2040 tactggcccc aatatgggag gtaaatcaac atatattcga caaactgggg tgatagtact 2100 catggcccaa attgggtgtt ttgtgccatg tgagtcagca gaagtgtcca ttgtggactg 2160 catcttagcc cgagtagggg ctggtgacag tcaattgaaa ggagtctcca cgttcatggc 2220 tgaaatgttg gaaactgctt ctatcctcag gtctgcaacc aaagattcat taataatcat 2280 agatgaattg ggaagaggaa cttctaccta cgatggattt gggttagcat gggctatatc 2340 agaatacatt gcaacaaaga ttggtgcttt ttgcatgttt gcaacccatt ttcatgaact 2400 tactgccttg gccaatcaga taccaactgt taataatcta catgtcacag cactcaccac 2460 tgaagagacc ttaactatgc tttatcaggt gaagaaaggt gtctgtgatc aaagttttgg 2520 gattcatgtt gcagagcttg ctaatttccc taagcatgta atagagtgtg ctaaacagaa 2580 agccctggaa cttgaggagt ttcagtatat tggagaatcg caaggatatg atatcatgga 2640 accagcagca aagaagtgct atctggaaag agagcaaggt gaaaaaatta ttcaggagtt 2700 cctgtccaag gtgaaacaaa tgccctttac tgaaatgtca gaagaaaaca tcacaataaa 2760 gttaaaacag ctaaaagctg aagtaatagc aaagaataat agctttgtaa atgaaatcat 2820 ttcacgaata aaagttacta cgtgaaaaat cccagtaatg gaatgaaggt aatattgata 2880 agctattgtc tgtaatagtt ttatattgtt ttatattaa 2919 <210> 497 <211> 3080 <212> DNA <213> Homo sapiens <400> 497 gacatggcgg tgcagccgaa ggagacgctg cagttggaga gcgcggccga ggtcggcttc 60 gtgcgcttct ttcagggcat gccggagaag ccgaccacca cagtgcgcct tttcgaccgg 120 ggcgacttct atacggcgca cggcgaggac gcgctgctgg ccgcccggga ggtgttcaag 180 acccaggggg tgatcaagta catggggccg gcaggagcaa agaatctgca gagtgttgtg 240 cttagtaaaa tgaattttga atcttttgta aaagatcttc ttctggttcg tcagtataga 300 gttgaagttt ataagaatag agctggaaat aaggcatcca aggagaatga ttggtatttg 360 gcatataagg cttctcctgg caatctctct cagtttgaag atattctctt tggtaacaat 420 gatatgtcag cttccattgg tgttgtgggt gttaaaatgt ccgcagttga tggccagaga 480 caggttggag ttgggtatgt ggattccata cagaggaaac taggactgtg tgaattccct 540 gataatgatc agttctccaa tcttgaggct ctcctcatcc agattggacc aaaggaatgt 600 gttttacccg gaggagagac tgctggagac atggggaaac tgagacagat aattcaaaga 660 ggaggaattc tgatcacaga aagaaaaaaa gctgactttt ccacaaaaga catttatcag 720 gacctcaacc ggttgttgaa aggcaaaaag ggagagcaga tgaatagtgc tgtattgcca 780 gaaatggaga atcaggttgc agtttcatca ctgtctgcgg taatcaagtt tttagaactc 840 ttatcagatg attccaactt tggacagttt gaactgacta cttttgactt cagccagtat 900 atgaaattgg atattgcagc agtcagagcc cttaaccttt ttcagggttc tgttgaagat 960 accactggct ctcagtctct ggctgccttg ctgaataagt gtaaaacccc tcaaggacaa 1020 agacttgtta accagtggat taagcagcct ctcatggata agaacagaat agaggagaga 1080 ttgaatttag tggaagcttt tgtagaagat gcagaattga ggcagacttt acaagaagat 1140 ttacttcgtc gattcccaga tcttaaccga cttgccaaga agtttcaaag acaagcagca 1200 aacttacaag attgttaccg actctatcag ggtataaatc aactacctaa tgttatacag 1260 gctctggaaa aacatgaagg aaaacaccag aaattattgt tggcagtttt tgtgactcct 1320 cttactgatc ttcgttctga cttctccaag tttcaggaaa tgatagaaac aactttagat 1380 atggatcagg tggaaaacca tgaattcctt gtaaaacctt catttgatcc taatctcagt 1440 gaattaagag aaataatgaa tgacttggaa aagaagatgc agtcaacatt aataagtgca 1500 gccagagatc ttggcttgga ccctggcaaa cagattaaac tggattccag tgcacagttt 1560 ggatattact ttcgtgtaac ctgtaaggaa gaaaaagtcc ttcgtaacaa taaaaacttt 1620 agtactgtag atatccagaa gaatggtgtt aaatttacca acagcaaatt gacttcttta 1680 aatgaagagt ataccaaaaa taaaacagaa tatgaagaag cccaggatgc cattgttaaa 1740 gaaattgtca atatttcttc aggctatgta gaaccaatgc agacactcaa tgatgtgtta 1800 gctcagctag atgctgttgt cagctttgct cacgtgtcaa atggagcacc tgttccatat 1860 gtacgaccag ccattttgga gaaaggacaa ggaagaatta tattaaaagc atccaggcat 1920 gcttgtgttg aagttcaaga tgaaattgca tttattccta atgacgtata ctttgaaaaa 1980 gataaacaga tgttccacat cattactggc cccaatatgg gaggtaaatc aacatatatt 2040 cgacaaactg gggtgatagt actcatggcc caaattgggt gttttgtgcc atgtgagtca 2100 gcagaagtgt ccattgtgga ctgcatctta gcccgagtag gggctggtga cagtcaattg 2160 aaaggagtct ccacgttcat ggctgaaatg ttggaaactg cttctatcct caggtctgca 2220 accaaagatt cattaataat catagatgaa ttgggaagag gaacttctac ctacgatgga 2280 tttgggttag catgggctat atcagaatac attgcaacaa agattggtgc tttttgcatg 2340 tttgcaaccc attttcatga acttactgcc ttggccaatc agataccaac tgttaataat 2400 ctacatgtca cagcactcac cactgaagag accttaacta tgctttatca ggtgaagaaa 2460 ggtgtctgtg atcaaagttt tgggattcat gttgcagagc ttgctaattt ccctaagcat 2520 gtaatagagt gtgctaaaca gaaagccctg gaacttgagg agtttcagta tattggagaa 2580 tcgcaaggat atgatatcat ggaaccagca gcaaagaagt gctatctgga aagagagcaa 2640 ggtgaaaaaa ttattcagga gttcctgtcc aaggtgaaac aaatgccctt tactgaaatg 2700 tcagaagaaa acatcacaat aaagttaaaa cagctaaaag ctgaagtaat agcaaagaat 2760 aatagctttg taaatgaaat catttcacga ataaaagtta ctacgtgaaa aatcccagta 2820 atggaatgaa ggtaatattg ataagctatt gtctgtaata gttttatatt gttttatatt 2880 aacccttttt ccatagtgtt aactgtcagt gcccatgggc tatcaactta ataagatatt 2940 tagtaatatt ttactttgag gacattttca aagattttta ttttgaaaaa tgagagctgt 3000 aactgaggac tgtttgcaat tgacataggc aataataagt gatgtgctga attttataaa 3060 taaaatcatg tagtttgtgg 3080 <210> 498 <211> 2920 <212> DNA <213> Homo sapiens <400> 498 tcgcgcattt tcttcaacca ggaggtgagg aggtttcgac atggcggtgc agccgaagga 60 gacgctgcag ttggagagcg cggccgaggt cggcttcgtg cgcttctttc agggcatgcc 120 ggagaagccg accaccacag tgcgcctttt cgaccggggc gacttctata cggcgcacgg 180 cgaggacgcg ctgctggccg cccgggaggt gttcaagacc cagggggtga tcaagtacat 240 ggggccggca ggagcaaaga atctgcagag tgttgtgctt agtaaaatga attttgaatc 300 ttttgtaaaa gatcttcttc tggttcgtca gtatagagtt gaagtttata agaatagagc 360 tggaaataag gcatccaagg agaatgattg gtatttggca tataaggctt ctcctggcaa 420 tctctctcag tttgaagaca ttctctttgg taacaatgat atgtcagctt ccattggtgt 480 tgtgggtgtt aaaatgtccg cagttgatgg ccagagacag gttggagttg ggtatgtgga 540 ttccatacag aggaaactag gactgtgtga attccctgat aatgatcagt tctccaatct 600 tgaggctctc ctcatccaga ttggaccaaa ggaatgtgtt ttacccggag gagagactgc 660 tggagacatg gggaaactga gacagataat tcaaagagga ggaattctga tcacagaaag 720 aaaaaaagct gacttttcca caaaagacat ttatcaggac ctcaaccggt tgttgaaagg 780 caaaaaggga gagcagatga atagtgctgt attgccagaa atggagaatc aggttgcagt 840 ttcatcactg tctgcggtaa tcaagttttt agaactctta tcagatgatt ccaactttgg 900 acagtttgaa ctgactactt ttgacttcag ccagtatatg aaattggata ttgcagcagt 960 cagagccctt aacctttttc agggttctgt tgaagatacc actggctctc agtctctggc 1020 tgccttgctg aataagtgta aaacccctca aggacaaaga cttgttaacc agtggattaa 1080 gcagcctctc atggataaga acagaataga ggagagattg aatttagtgg aagcttttgt 1140 agaagatgca gaattgaggc agactttaca agaagattta cttcgtcgat tcccagatct 1200 taaccgactt gccaagaagt ttcaaagaca agcagcaaac ttacaagatt gttaccgact 1260 ctatcagggt ataaatcaac tacctaatgt tatacaggct ctggaaaaac atgaaggaaa 1320 acaccagaaa ttattgttgg cagtttttgt gactcctctt actgatcttc gttctgactt 1380 ctccaagttt caggaaatga tagaaacaac tttagatatg gatcaggtgg aaaaccatga 1440 attccttgta aaaccttcat ttgatcctaa tctcagtgaa ttaagagaaa taatgaatga 1500 cttggaaaag aagatgcagt caacattaat aagtgcagcc agagatcttg gcttggaccc 1560 tggcaaacag attaaactgg attccagtgc acagtttgga tattactttc gtgtaacctg 1620 taaggaagaa aaaggtcctt cgtaacaata aaaactttag tactgtagat atccagaaga 1680 atggtgttaa atttaccaac agcaaattga cttctttaaa tgaagagtat accaaaaata 1740 aaacagaata tgaagaagcc caggatgcca ttgttaaaga aattgtcaat atttcttcag 1800 gctatgtaga accaatgcag acactcaatg atgtgttagc tcagctagat gctgttgtca 1860 gctttgctca cgtgtcaaat ggagcacctg ttccatatgt acgaccagcc attttggaga 1920 aaggacaagg aagaattata ttaaaagcat ccaggcatgc ttgtgttgaa gttcaagatg 1980 aaattgcatt tattcctaat gacgtatact ttgaaaaaga taaacagatg ttccacatca 2040 ttactggccc caatatggga ggtaaatcaa catatattcg acaaactggg gtgatagtac 2100 tcatggccca aattgggtgt tttgtgccat gtgagtcagc agaagtgtcc attgtggact 2160 gcatcttagc ccgagtaggg gctggtgaca gtcaattgaa aggagtctcc acgttcatgg 2220 ctgaaatgtt ggaaactgct tctatcctca ggtctgcaac caaagattca ttaataatca 2280 tagatgaatt gggaagagga acttctacct acgatggatt tgggttagca tgggctatat 2340 cagaatacat tgcaacaaag attggtgctt tttgcatgtt tgcaacccat tttcatgaac 2400 ttactgcctt ggccaatcag ataccaactg ttaataatct acatgtcaca gcactcacca 2460 ctgaagagac cttaactatg ctttatcagg tgaagaaagg tgtctgtgat caaagttttg 2520 ggattcatgt tgcagagctt gctaatttcc ctaagcatgt aatagagtgt gctaaacaga 2580 aagccctgga acttgaggag tttcagtata ttggagaatc gcaaggatat gatatcatgg 2640 aaccagcagc aaagaagtgc tatctggaaa gagagcaagg tgaaaaaatt attcaggagt 2700 tcctgtccaa ggtgaaacaa atgcccttta ctgaaatgtc agaagaaaac atcacaataa 2760 agttaaaaca gctaaaagct gaagtaatag caaagaataa tagctttgta aatgaaatca 2820 tttcacgaat aaaagttact acgtgaaaaa tcccagtaat ggaatgaagg taatattgat 2880 aagctattgt ctgtaatagt tttatattgt tttatattaa 2920 <210> 499 <211> 2920 <212> DNA <213> Homo sapiens <400> 499 tcgcgcattt tcttcaacca ggaggtgagg aggtttcgac atggcggtgc agccgaagga 60 gacgctgcag ttggagagcg cggccgaggt cggcttcgtg cgcttctttc agggcatgcc 120 ggagaagccg accaccacag tgcgcctttt cgaccggggc gacttctata cggcgcacgg 180 cgaggacgcg ctgctggccg cccgggaggt gttcaagacc cagggggtga tcaagtacat 240 ggggccggca ggagcaaaga atctgcagag tgttgtgctt agtaaaatga attttgaatc 300 ttttgtaaaa gatcttcttc tggttcgtca gtatagagtt gaagtttata agaatagagc 360 tggaaataag gcatccaagg agaatgattg gtatttggca tataaggctt ctcctggcaa 420 tctctctcag tttgaagaca ttctctttgg taacaatgat atgtcagctt ccattggtgt 480 tgtgggtgtt aaaatgtccg cagttgatgg ccagagacag gttggagttg ggtatgtgga 540 ttccatacag aggaaactag gactgtgtga attccctgat aatgatcagt tctccaatct 600 tgaggctctc ctcatccaga ttggaccaaa ggaatgtgtt ttacccggag gagagactgc 660 tggagacatg gggaaactga gacagataat tcaaagagga ggaattctga tcacagaaag 720 aaaaaaagct gacttttcca caaaagacat ttatcaggac ctcaaccggt tgttgaaagg 780 caaaaaggga gagcagatga atagtgctgt attgccagaa atggagaatc aggttgcagt 840 ttcatcactg tctgcggtaa tcaagttttt agaactctta tcagatgatt ccaactttgg 900 acagtttgaa ctgactactt ttgacttcag ccagtatatg aaattggata ttgcagcagt 960 cagagccctt aacctttttc agggttctgt tgaagatacc actggctctc agtctctggc 1020 tgccttgctg aataagtgta aaacccctca aggacaaaga cttgttaacc agtggattaa 1080 gcagcctctc atggataaga acagaataga ggagagattg aatttagtgg aagcttttgt 1140 agaagatgca gaattgaggc agactttaca agaagattta cttcgtcgat tcccagatct 1200 taaccgactt gccaagaagt ttcaaagaca agcagcaaac ttacaagatt gttaccgact 1260 ctatcagggt ataaatcaac tacctaatgt tatacaggct ctggaaaaac atgaaggaaa 1320 acaccagaaa ttattgttgg cagtttttgt gactcctctt actgatcttc gttctgactt 1380 ctccaagttt caggaaatga tagaaacaac tttagatatg gatcaggtgg aaaaccatga 1440 attccttgta aaaccttcat ttgatcctaa tctcagtgaa ttaaagagaa ataatgaatg 1500 acttggaaaa gaagatgcag tcaacattaa taagtgcagc cagagatctt ggcttggacc 1560 ctggcaaaca gattaaactg gattccagtg cacagtttgg atattacttt cgtgtaacct 1620 gtaaggaaga aaaagtcctt cgtaacaata aaaactttag tactgtagat atccagaaga 1680 atggtgttaa atttaccaac agcaaattga cttctttaaa tgaagagtat accaaaaata 1740 aaacagaata tgaagaagcc caggatgcca ttgttaaaga aattgtcaat atttcttcag 1800 gctatgtaga accaatgcag acactcaatg atgtgttagc tcagctagat gctgttgtca 1860 gctttgctca cgtgtcaaat ggagcacctg ttccatatgt acgaccagcc attttggaga 1920 aaggacaagg aagaattata ttaaaagcat ccaggcatgc ttgtgttgaa gttcaagatg 1980 aaattgcatt tattcctaat gacgtatact ttgaaaaaga taaacagatg ttccacatca 2040 ttactggccc caatatggga ggtaaatcaa catatattcg acaaactggg gtgatagtac 2100 tcatggccca aattgggtgt tttgtgccat gtgagtcagc agaagtgtcc attgtggact 2160 gcatcttagc ccgagtaggg gctggtgaca gtcaattgaa aggagtctcc acgttcatgg 2220 ctgaaatgtt ggaaactgct tctatcctca ggtctgcaac caaagattca ttaataatca 2280 tagatgaatt gggaagagga acttctacct acgatggatt tgggttagca tgggctatat 2340 cagaatacat tgcaacaaag attggtgctt tttgcatgtt tgcaacccat tttcatgaac 2400 ttactgcctt ggccaatcag ataccaactg ttaataatct acatgtcaca gcactcacca 2460 ctgaagagac cttaactatg ctttatcagg tgaagaaagg tgtctgtgat caaagttttg 2520 ggattcatgt tgcagagctt gctaatttcc ctaagcatgt aatagagtgt gctaaacaga 2580 aagccctgga acttgaggag tttcagtata ttggagaatc gcaaggatat gatatcatgg 2640 aaccagcagc aaagaagtgc tatctggaaa gagagcaagg tgaaaaaatt attcaggagt 2700 tcctgtccaa ggtgaaacaa atgcccttta ctgaaatgtc agaagaaaac atcacaataa 2760 agttaaaaca gctaaaagct gaagtaatag caaagaataa tagctttgta aatgaaatca 2820 tttcacgaat aaaagttact acgtgaaaaa tcccagtaat ggaatgaagg taatattgat 2880 aagctattgt ctgtaatagt tttatattgt tttatattaa 2920 <210> 500 <211> 3116 <212> DNA <213> Homo sapiens <400> 500 ggaggtgagg aggtttcgac atggcggtgc agccgaagga gacgctgcag ttggagagcg 60 cggccgaggt cggcttcgtg cgcttctttc agggcatgcc ggagaagccg accaccacag 120 tgcgcctttt cgaccggggc gacttctata cggcgcacgg cgaggacgcg ctgctggccg 180 cccgggaggt gttcaagacc cagggggtga tcaagtacat ggggccggca ggagcaaaga 240 atctgcagag tgttgtgctt agtaaaatga attttgaatc ttttgtaaaa gatcttcttc 300 tggttcgtca gtatagagtt gaagtttata agaatagagc tggaaataag gcatccaagg 360 agaatgattg gtatttggca tataaggctt ctcctggcaa tctctctcag tttgaagaca 420 ttctctttgg taacaatgat atgtcagctt ccattggtgt tgtgggtgtt aaaatgtccg 480 cagttgatgg ccagagacag gttggagttg ggtatgtgga ttccatacag aggaaactag 540 gactgtgtga attccctgat aatgatcagt tctccaatct tgaggctctc ctcatccaga 600 ttggaccaaa ggaatgtgtt ttacccggag gagagactgc tggagacatg gggaaactga 660 gacagataat tcaaagagga ggaattctga tcacagaaag aaaaaaagct gacttttcca 720 caaaagacat ttatcaggac ctcaaccggt tgttgaaagg caaaaaggga gagcagatga 780 atagtgctgt attgccagaa atggagaatc aggttgcagt ttcatcactg tctgcggtaa 840 tcaagttttt agaactctta tcagatgatt ccaactttgg acagtttgaa ctgactactt 900 ttgacttcag ccagtatatg aaattggata ttgcagcagt cagagccctt aacctttttc 960 agggttctgt tgaagatacc actggctctc agtctctggc tgccttgctg aataagtgta 1020 aaacccctca aggacaaaga cttgttaacc agtggattaa gcagcctctc atggataaga 1080 acagaataga ggagagattg aatttagtgg aagcttttgt agaagatgca gaattgaggc 1140 agactttaca agaagattta cttcgtcgat tcccagatct taaccgactt gccaagaagt 1200 ttcaaagaca agcagcaaac ttacaagatt gttaccgact ctatcagggt ataaatcaac 1260 tacctaatgt tatacaggct ctggaaaaac atgaaggaaa acaccagaaa ttattgttgg 1320 cagtttttgt gactcctctt actgatcttc gttctgactt ctccaagttt caggaaatga 1380 tagaaacaac tttagatatg gatcaggtgg aaaaccatga attccttgta aaaccttcat 1440 ttgatcctaa tctcagtgaa ttaagagaaa taatgaatga cttggaaaag aagatgcagt 1500 caacattaat aagtgcagcc agagatcttg gcttggaccc tggcaaacag attaaactgg 1560 attccagtgc acagtttgga tattactttc gtgtaacctg taaggaagaa aaagtccttc 1620 gtaacaataa aaactttagt actgtagata tccagaagaa tggtgttaaa tttaccaaca 1680 gcaaattgac ttctttaaat gaagagtata ccaaaaataa aacagaatat gaagaagccc 1740 aggatgccat tgttaaagaa attgtcaata tttcttcagg ctatgtagaa ccaatgcaga 1800 cactcaatga tgtgttagct cagctagatg ctgttgtcag ctttgctcac gtgtcaaatg 1860 gagcacctgt tccatatgta cgaccagcca ttttggagaa aggacaagga agaattatat 1920 taaaagcatc caggcatgct tgtgttgaag ttcaagatga aattgcattt attcctaatg 1980 acgtatactt tgaaaaagat aaacagatgt tccacatcat tactggcccc aatatgggag 2040 gtaaatcaac atatattcga caaactgggg tgatagtact catggcccaa attgggtgtt 2100 ttgtgccatg tgagtcagca gaagtgtcca ttgtggactg catcttagcc cgagtagggg 2160 ctggtgacag tcaattgaaa ggagtctcca cgttcatggc tgaaatgttg gaaactgctt 2220 ctatcctcag gtctgcaacc aaagattcat taataatcat agatgaattg ggaagaggaa 2280 cttctaccta cgatggattt gggttagcat gggctatatc agaatacatt gcaacaaaga 2340 ttggtgcttt ttgcatgttt gcaacccata ttcatgaact tactgccttg gccaatcaga 2400 taccaactgt taataatcta catgtcacag cactcaccac tgaagagacc ttaactatgc 2460 tttatcaggt gaagaaaggt gtctgtgatc aaagttttgg gattcatgtt gcagagcttg 2520 ctaattcccc taagcatgta atagagtgtg ctaaacagaa agccctggaa cttgaggagt 2580 ttcagtatat tggagaatcg caaggatatg atatcatgga accagcagca aagaagtgct 2640 atctggaaag agagcaaggt gaaaaaatta ttcaggagtt cctgtccaag gtgaaacaaa 2700 tgccctttac tgaaatgtca gaagaaaaca tcacaataaa gttaaaacag ctaaaagctg 2760 aagtaatagc aaagaataat agctttgtaa atgaaatcat ttcacgaata aaagttacta 2820 cgtgaaaaat cccagtaatg gaatgaaggt aatattgata agctattgtc tgtaatagtt 2880 ttatattgtt ttatattaac cctttttcca tagtgttaac tgtcagtgcc catgggctat 2940 caacttaata agatatttag taatatttta ctttgaggac attttcaaag atttttattt 3000 tgaaaaatga gagctgtaac tgaggactgt ttgcaattga cataggcaat aataagtgat 3060 gtgctgaatt ttataaataa aatcatgtag tttgtggaaa aaaaaaaaaa aaaaaa 3116 <210> 501 <211> 2918 <212> DNA <213> Homo sapiens <400> 501 tcgcgcattt tcttcaacca ggaggtgagg aggtttcgac atggcggtgc agccgaagga 60 gacgctgcag ttggagagcg cggccgaggt cggcttcgtg cgcttctttc agggcatgcc 120 ggagaagccg accaccacag tgcgcctttt cgaccggggc gacttctata cggcgcacgg 180 cgaggacgcg ctgctggccg cccgggaggt gttcaagacc cagggggtga tcaagtacat 240 ggggccggca ggagcaaaga atctgcagag tgttgtgctt agtaaaatga attttgaatc 300 ttttgtaaaa gatcttcttc tggttcgtca gtatagagtt gaagtttata agaatagagc 360 tggaaataag gcatccaagg agaatgattg gtatttggca tataaggctt ctcctggcaa 420 tctctctcag tttgaagaca ttctctttgg taacaatgat atgtcagctt ccattggtgt 480 tgtgggtgtt aaaatgtccg cagttgatgg ccagagacag gttggagttg ggtatgtgga 540 ttccatacag aggaaactag gactgtgtga attccctgat aatgatcagt tctccaatct 600 tgaggctctc ctcatccaga ttggaccaaa ggaatgtgtt ttacccggag gagagactgc 660 tggagacatg gggaaactga gacagataat tcaaagagga ggaattctga tcacagaaag 720 aaaaaaagct gacttttcca caaaagacat ttatcaggac ctcaaccggt tgttgaaagg 780 caaaaaggga gagcagatga atagtgctgt attgccagaa atggagaatc aggttgcagt 840 ttcatcactg tctgcggtaa tcaagttttt agaactctta tcagatgatt ccaactttgg 900 acagtttgaa ctgactactt ttgacttcag ccagtatatg aaattggata ttgcagcagt 960 cagagccctt aacctttttc agggttctgt tgaagatacc actggctctc agtctctggc 1020 tgccttgctg aataagtgta aaacccctca aggacaaaga cttgttaacc agtggattaa 1080 gcagcctctc atggataaga acagaataga ggagagattg aatttagtgg aagcttttgt 1140 agaagatgca gaattgaggc agactttaca agaagattta cttcgtcgat tcccagatct 1200 taaccgactt gccaagaagt ttcaaagaca agcagcaaac ttacaagatt gttaccgact 1260 ctatcagggt ataaatcaac tacctaatgt tatacaggct ctggaaaaac atgaaggaaa 1320 acaccagaaa ttattgttgg cagtttttgt gactcctctt actgatcttc gttctgactt 1380 ctccaagttt caggaaatga tagaaacaac tttagatatg gatcaggtgg aaaaccatga 1440 attccttgta aaaccttcat ttgatcctaa tctcagtgaa ttaagagaaa taatgaatga 1500 cttggaaaag aagatgcagt caacattaat aagtgcagcc agagatcttg gcttggaccc 1560 tggcaaacag attaaactgg attccagtgc acagtttgga tattactttc gtgtaacctg 1620 taaggaagaa aaagtccttc gtaacaataa aaactttagt actgtagata tccagaagaa 1680 tggtgttaaa tttaccaaca gcaaattgac ttctttaaat gaagagtata ccaaaaataa 1740 aacagaatat gaagaagccc aggatgccat tgttaaagaa attgtcaata tttcttcagg 1800 ctatgtagaa ccaatgcaga cactcaatga tgtgttagct cagctagatg ctgttgtcag 1860 ctttgctcac gtgtcaaatg gagcacctgt tccatatgta cgaccagcca ttttggagaa 1920 aggacaagga agaattatat taaaagcatc caggcatgct tgtgttgaag ttcaagatga 1980 aattgcattt attcctaatg acgtatactt tgaaaaagat aaacagatgt tccacatcat 2040 tactggcccc aatatgggag gtaaatcaac atatattcga caaactgggg tgatagtact 2100 catggcccaa attgggtgtt ttgtgccatg tgagtcagca gaagtgtcca ttgtggactg 2160 catcttagcc cgagtagggg ctggtgacag tcaattgaaa ggagtctcca cgttcatggc 2220 tgaaatgttg gaaactgctt ctatcctcag gtctgcaacc aaagattcat taataatcat 2280 agatgaattg ggaagaggaa cttctaccta cgatggattt gggttagcat gggctatatc 2340 agaatacatt gcaacaaaga ttggtgcttt ttgcatgttt gcaaccattt tcatgaactt 2400 actgccttgg ccaatcagat accaactgtt aataatctac atgtcacagc actcaccact 2460 gaagagacct taactatgct ttatcaggtg aagaaaggtg tctgtgatca aagttttggg 2520 attcatgttg cagagcttgc taatttccct aagcatgtaa tagagtgtgc taaacagaaa 2580 gccctggaac ttgaggagtt tcagtatatt ggagaatcgc aaggatatga tatcatggaa 2640 ccagcagcaa agaagtgcta tctggaaaga gagcaaggtg aaaaaattat tcaggagttc 2700 ctgtccaagg tgaaacaaat gccctttact gaaatgtcag aagaaaacat cacaataaag 2760 ttaaaacagc taaaagctga agtaatagca aagaataata gctttgtaaa tgaaatcatt 2820 tcacgaataa aagttactac gtgaaaaatc ccagtaatgg aatgaaggta atattgataa 2880 gctattgtct gtaatagttt tatattgttt tatattaa 2918 <210> 502 <211> 2918 <212> DNA <213> Homo sapiens <400> 502 tcgcgcattt tcttcaacca ggaggtgagg aggtttcgac atggcggtgc agccgaagga 60 gacgctgcag ttggagagcg cggccgaggt cggcttcgtg cgcttctttc agggcatgcc 120 ggagaagccg accaccacag tgcgcctttt cgaccggggc gacttctata cggcgcacgg 180 cgaggacgcg ctgctggccg cccgggaggt gttcaagacc cagggggtga tcaagtacat 240 ggggccggca ggagcaaaga atctgcagag tgttgtgctt agtaaaatga attttgaatc 300 ttttgtaaaa gatcttcttc tggttcgtca gtatagagtt gaagtttata agaatagagc 360 tggaaataag gcatccaagg agaatgattg gtatttggca tataaggctt ctcctggcaa 420 tctctctcag tttgaagaca ttctctttgg taacaatgat atgtcagctt ccattggtgt 480 tgtgggtgtt aaaatgtccg cagttgatgg ccagagacag gttggagttg ggtatgtgga 540 ttccatacag aggaaactag gactgtgtga attccctgat aatgatcagt tctccaatct 600 tgaggctctc ctcatccaga ttggaccaaa ggaatgtgtt ttacccggag gagagactgc 660 tggagacatg gggaaactga gacagataat tcaaagagga ggaattctga tcacagaaag 720 aaaaaaagct gacttttcca caaaagacat ttatcaggac ctcaaccggt tgttgaaagg 780 caaaaaggga gagcagatga atagtgctgt attgccagaa atggagaatc aggttgcagt 840 ttcatcactg tctgcggtaa tcaagttttt agaactctta tcagatgatt ccaactttgg 900 acagtttgaa ctgactactt ttgacttcag ccagtatatg aaattggata ttgcagcagt 960 cagagccctt aacctttttc agggttctgt tgaagatacc actggctctc agtctctggc 1020 tgccttgctg aataagtgta aaacccctca aggacaaaga cttgttaacc agtggattaa 1080 gcagcctctc atggataaga acagaataga ggagagattg aatttagtgg aagcttttgt 1140 agaagatgca gaattgaggc agactttaca agaagattac ttcgtcgatt cccagatctt 1200 aaccgacttg ccaagaagtt tcaaagacaa gcagcaaact tacaagattg ttaccgactc 1260 tatcagggta taaatcaact acctaatgtt atacaggctc tggaaaaaca tgaaggaaaa 1320 caccagaaat tattgttggc agtttttgtg actcctctta ctgatcttcg ttctgacttc 1380 tccaagtttc aggaaatgat agaaacaact ttagatatgg atcaggtgga aaaccatgaa 1440 ttccttgtaa aaccttcatt tgatcctaat ctcagtgaat taagagaaat aatgaatgac 1500 ttggaaaaga agatgcagtc aacattaata agtgcagcca gagatcttgg cttggaccct 1560 ggcaaacaga ttaaactgga ttccagtgca cagtttggat attactttcg tgtaacctgt 1620 aaggaagaaa aagtccttcg taacaataaa aactttagta ctgtagatat ccagaagaat 1680 ggtgttaaat ttaccaacag caaattgact tctttaaatg aagagtatac caaaaataaa 1740 acagaatatg aagaagccca ggatgccatt gttaaagaaa ttgtcaatat ttcttcaggc 1800 tatgtagaac caatgcagac actcaatgat gtgttagctc agctagatgc tgttgtcagc 1860 tttgctcacg tgtcaaatgg agcacctgtt ccatatgtac gaccagccat tttggagaaa 1920 ggacaaggaa gaattatatt aaaagcatcc aggcatgctt gtgttgaagt tcaagatgaa 1980 attgcattta ttcctaatga cgtatacttt gaaaaagata aacagatgtt ccacatcatt 2040 actggcccca atatgggagg taaatcaaca tatattcgac aaactggggt gatagtactc 2100 atggcccaaa ttgggtgttt tgtgccatgt gagtcagcag aagtgtccat tgtggactgc 2160 atcttagccc gagtaggggc tggtgacagt caattgaaag gagtctccac gttcatggct 2220 gaaatgttgg aaactgcttc tatcctcagg tctgcaacca aagattcatt aataatcata 2280 gatgaattgg gaagaggaac ttctacctac gatggatttg ggttagcatg ggctatatca 2340 gaatacattg caacaaagat tggtgctttt tgcatgtttg caacccattt tcatgaactt 2400 actgccttgg ccaatcagat accaactgtt aataatctac atgtcacagc actcaccact 2460 gaagagacct taactatgct ttatcaggtg aagaaaggtg tctgtgatca aagttttggg 2520 attcatgttg cagagcttgc taatttccct aagcatgtaa tagagtgtgc taaacagaaa 2580 gccctggaac ttgaggagtt tcagtatatt ggagaatcgc aaggatatga tatcatggaa 2640 ccagcagcaa agaagtgcta tctggaaaga gagcaaggtg aaaaaattat tcaggagttc 2700 ctgtccaagg tgaaacaaat gccctttact gaaatgtcag aagaaaacat cacaataaag 2760 ttaaaacagc taaaagctga agtaatagca aagaataata gctttgtaaa tgaaatcatt 2820 tcacgaataa aagttactac gtgaaaaatc ccagtaatgg aatgaaggta atattgataa 2880 gctattgtct gtaatagttt tatattgttt tatattaa 2918 <210> 503 <211> 2917 <212> DNA <213> Homo sapiens <400> 503 tcgcgcattt tcttcaacca ggaggtgagg aggtttcgac atggcggtgc agccgaagga 60 gacgctgcag ttggagagcg cggccgaggt cggcttcgtg cgcttctttc agggcatgcc 120 ggagaagccg accaccacag tgcgcctttt cgaccggggc gacttctata cggcgcacgg 180 cgaggacgcg ctgctggccg cccgggaggt gttcaagacc cagggggtga tcaagtacat 240 ggggccggca ggagcaaaga atctgcagag tgttgtgctt agtaaaatga attttgaatc 300 ttttgtaaaa gatcttcttc tggttcgtca gtatagagtt gaagtttata agaatagagc 360 tggaaataag gcatccaagg agaatgattg gtatttggca tataaggctt ctcctggcaa 420 tctctctcag tttgaagaca ttctctttgg taacaatgat atgtcagctt ccattggtgt 480 tgtgggtgtt aaaatgtccg cagttgatgg ccagagacag gttggagttg ggtatgtgga 540 ttccatacag aggaaactag gactgtgtga attccctgat aatgatcagt tctccaatct 600 tgaggctctc ctcatccaga ttggaccaaa ggaatgtgtt ttacccggag gagagactgc 660 tggagacatg gggaaactga gacagataat tcaaagagga ggaattctga tcacagaaag 720 aaaaaaagct gacttttcca caaaagacat ttatcaggac ctcaaccggt tgttgaaagg 780 caaaaaggga gagcagatga atagtgctgt attgccagaa atggagaatc aggttgcagt 840 ttcatcactg tctgcggtaa tcaagttttt agaactctta tcagatgatt ccaactttgg 900 acagtttgaa ctgactactt ttgacttcag ccagtatatg aaattggata ttgcagcagt 960 cagagccctt aacctttttc agggttctgt tgaagatacc actggctctc agtctctggc 1020 tgccttgctg aataagtgta aaacccctca aggacagact tgttaaccag tggattaagc 1080 agcctctcat ggataagaac agaatagagg agagattgaa tttagtggaa gcttttgtag 1140 aagatgcaga attgaggcag actttacaag aagatttact tcgtcgattc ccagatctta 1200 accgacttgc caagaagttt caaagacaag cagcaaactt acaagattgt taccgactct 1260 atcagggtat aaatcaacta cctaatgtta tacaggctct ggaaaaacat gaaggaaaac 1320 accagaaatt attgttggca gtttttgtga ctcctcttac tgatcttcgt tctgacttct 1380 ccaagtttca ggaaatgata gaaacaactt tagatatgga tcaggtggaa aaccatgaat 1440 tccttgtaaa accttcattt gatcctaatc tcagtgaatt aagagaaata atgaatgact 1500 tggaaaagaa gatgcagtca acattaataa gtgcagccag agatcttggc ttggaccctg 1560 gcaaacagat taaactggat tccagtgcac agtttggata ttactttcgt gtaacctgta 1620 aggaagaaaa agtccttcgt aacaataaaa actttagtac tgtagatatc cagaagaatg 1680 gtgttaaatt taccaacagc aaattgactt ctttaaatga agagtatacc aaaaataaaa 1740 cagaatatga agaagcccag gatgccattg ttaaagaaat tgtcaatatt tcttcaggct 1800 atgtagaacc aatgcagaca ctcaatgatg tgttagctca gctagatgct gttgtcagct 1860 ttgctcacgt gtcaaatgga gcacctgttc catatgtacg accagccatt ttggagaaag 1920 gacaaggaag aattatatta aaagcatcca ggcatgcttg tgttgaagtt caagatgaaa 1980 ttgcatttat tcctaatgac gtatactttg aaaaagataa acagatgttc cacatcatta 2040 ctggccccaa tatgggaggt aaatcaacat atattcgaca aactggggtg atagtactca 2100 tggcccaaat tgggtgtttt gtgccatgtg agtcagcaga agtgtccatt gtggactgca 2160 tcttagcccg agtaggggct ggtgacagtc aattgaaagg agtctccacg ttcatggctg 2220 aaatgttgga aactgcttct atcctcaggt ctgcaaccaa agattcatta ataatcatag 2280 atgaattggg aagaggaact tctacctacg atggatttgg gttagcatgg gctatatcag 2340 aatacattgc aacaaagatt ggtgcttttt gcatgtttgc aacccatttt catgaactta 2400 ctgccttggc caatcagata ccaactgtta ataatctaca tgtcacagca ctcaccactg 2460 aagagacctt aactatgctt tatcaggtga agaaaggtgt ctgtgatcaa agttttggga 2520 ttcatgttgc agagcttgct aatttcccta agcatgtaat agagtgtgct aaacagaaag 2580 ccctggaact tgaggagttt cagtatattg gagaatcgca aggatatgat atcatggaac 2640 cagcagcaaa gaagtgctat ctggaaagag agcaaggtga aaaaattatt caggagttcc 2700 tgtccaaggt gaaacaaatg ccctttactg aaatgtcaga agaaaacatc acaataaagt 2760 taaaacagct aaaagctgaa gtaatagcaa agaataatag ctttgtaaat gaaatcattt 2820 cacgaataaa agttactacg tgaaaaatcc cagtaatgga atgaaggtaa tattgataag 2880 ctattgtctg taatagtttt atattgtttt atattaa 2917 <210> 504 <211> 1222 <212> DNA <213> Homo sapiens <400> 504 gacatggcgg tgcagccgaa ggagacgctg cagttggaga gcgcggccga ggtcggcttc 60 gtgcgcttct ttcagggcat gccggagaag ccgaccacca cagtgcgcct tttcgaccgg 120 ggcgacttct atacggcgca cggcgaggac gcgctgctgg ccgcccggga ggtgttcaag 180 acccaggggg tgatcaagta catggggccg gcaggagcaa agaatctgca gagtgttgtg 240 cttagtaaaa tgaattttga atcttttgta aaagatcttc ttctggttcg tcagtataga 300 gttgaagttt ataagaatag agctggaaat aaggcatcca aggagaatga ttggtatttg 360 gcatataagg cttctcctgg caatctctct cagtttgaag acattctctt tggtaacaat 420 gatatgtcag cttccattgg tgttgtgggt gttaaaatgt ccgcagttga tggccagaga 480 caggttggag ttgggtatgt ggattccata cagaggaaac taggactgtg tgaattccct 540 gataatgatc agttctccaa tcttgaggct ctcctcatcc agattggacc aaaggaatgt 600 gttttacccg gaggagagac tgctggagac atggggaaac tgagacagat aattcaaaga 660 ggaggaattc tgatcacaga aagaaaaaaa gctgactttt ccacaaaaga catttatcag 720 gacctcaacc ggttgttgaa aggcaaaaag ggagagcaga tgaatagtgc tgtattgcca 780 gaaatggaga atcaggttgc agtttcatca ctgtctgcgg taatcaagtt tttagaactc 840 ttatcagatg attccaactt tggacagttt gaactgacta cttttgactt cagccagtat 900 atgaaattgg atattgcagc agtcagagcc cttaaccttt ttcagggttc tgttgaagat 960 accactggct ctcagtctct ggctgccttg ctgaataagt gtaaaacccc tcaaggacaa 1020 agacttgtta accagtggat taagcagcct ctcatggata agaacagaat agaggagaga 1080 ttgaatttag tggaagcttt tgtagaagat gcagaattga ggcagacttt acaagaagat 1140 ttacttcgtc gattcccaga tcttaaccga cttgccaaga agtttcaaag acaagcagca 1200 aacaaaaaaa aaaaaaaaaa aa 1222 <210> 505 <211> 778 <212> DNA <213> Homo sapiens <400> 505 ggggggaggc gggaaacagc ttagtgggtg tggggtcgcg cattttcttc aaccaggagg 60 tgaggaggtt tcgacatggc ggtgcagccg aaggagacgc tgcagttgga gagcgcggcc 120 gaggtcggct tcgtgcgctt ctttcagggc atgccggaga agccgaccac cacagtgcgc 180 cttttcgacc ggggcgactt ctatacggcg cacggcgagg acgcgctgct ggccgcccgg 240 gaggtgttca agacccaggg ggtgatcaag tacatggggc cggcaggagc aaagaatctg 300 cagagtgttg tgcttagtaa aatgaatttt gaatcttttg taaaagatct tcttctggtt 360 cgtcagtata gagttgaagt ttataagaat agagctggaa ataaggcatc caaggagaat 420 gattggtatt tggcatataa ggcttctcct ggcaatctct ctcagtttga agacattctc 480 tttggtaaca atgatatgtc agcttccatt ggtgttgtgg gtgttaaaat gtccgcagtt 540 gatggccaga gacaggttgg agttgggtat gtggattcca tacagaggaa actaggactg 600 tgtgaattcc ctgataatga tcagttctcc aatcttgagg ctctcctcat ccagattgga 660 ccaaaggaat gtgttttacc cggaggagag actgctggag acatggggaa actgagacag 720 ataattcaaa gaggaggaat tctgatcaca aaaaaaaaaa aaaaaaaaaa aaaaaaaa 778 <210> 506 <211> 3121 <212> DNA <213> Homo sapiens <400> 506 ggcacgagtg gctgcttgcg gctagtggat ggtaattgcc tgcctcgcgc tagcagcaag 60 ctgctctgtt aaaagcgaaa atgaaacaat tgcctgcggc aacagttcga ctcctttcaa 120 gttctcagat catcacttcg gtggtcagtg ttgtaaaaga gcttattgaa aactccttgg 180 atgctggtgc cacaagcgta gatgttaaac tggagaacta tggatttgat aaaattgagg 240 tgcgagataa cggggagggt atcaaggctg ttgatgcacc tgtaatggca atgaagtact 300 acacctcaaa aataaatagt catgaagatc ttgaaaattt gacaacttac ggttttcgtg 360 gagaagcctt ggggtcaatt tgttgtatag ctgaggtttt aattacaaca agaacggctg 420 ctgataattt tagcacccag tatgttttag atggcagtgg ccacatactt tctcagaaac 480 cttcacatct tggtcaaggt acaactgtaa ctgctttaag attatttaag aatctacctg 540 taagaaagca gttttactca actgcaaaaa aatgtaaaga tgaaataaaa aagatccaag 600 atctcctcat gagctttggt atccttaaac ctgacttaag gattgtcttt gtacataaca 660 aggcagttat ttggcagaaa agcagagtat cagatcacaa gatggctctc atgtcagttc 720 tggggactgc tgttatgaac aatatggaat cctttcagta ccactctgaa gaatctcaga 780 tttatctcag tggatttctt ccaaagtgtg atgcagacca ctctttcact agtctttcaa 840 caccagaaag aagtttcatc ttcataaaca gtcgaccagt acatcaaaaa gatatcttaa 900 agttaatccg acatcattac aatctgaaat gcctaaagga atctactcgt ttgtatcctg 960 ttttctttct gaaaatcgat gttcctacag ctgatgttga tgtaaattta acaccagata 1020 aaagccaagt attattacaa aataaggaat ctgttttaat tgctcttgaa aatctgatga 1080 cgacttgtta tggaccatta cctagtacaa attcttatga aaataataaa acagatgttt 1140 ccgcagctga catcgttctt agtaaaacag cagaaacaga tgtgcttttt aataaagtgg 1200 aatcatctgg aaagaattat tcaaatgttg atacttcagt cattccattc caaaatgata 1260 tgcataatga tgaatctgga aaaaacactg atgattgttt aaatcaccag ataagtattg 1320 gtgactttgg ttatggtcat tgtagtagtg aaatttctaa cattgataaa aacactaaga 1380 atgcatttca ggacatttca atgagtaatg tatcatggga gaactctcag acggaatata 1440 gtaaaacttg ttttataagt tccgttaagc acacccagtc agaaaatggc aataaagacc 1500 atatagatga gagtggggaa aatgaggaag aagcaggtct tgaaaactct tcggaaattt 1560 ctgcagatga gtggagcagg ggaaatatac ttaaaaattc agtgggagag aatattgaac 1620 ctgtgaaaat tttagtgcct gaaaaaagtt taccatgtaa agtaagtaat aataattatc 1680 caatccctga acaaatgaat cttaatgaag attcatgtaa caaaaaatca aatgtaatag 1740 ataataaatc tggaaaagtt acagcttatg atttacttag caatcgagta atcaagaaac 1800 ccatgtcagc aagtgctctt tttgttcaag atcatcgtcc tcagtttctc atagaaaatc 1860 ctaagactag tttagaggat gcaacactac aaattgaaga actgtggaag acattgagtg 1920 aagaggaaaa actgaaatat gaagagaagg ctactaaaga cttggaacga tacaatagtc 1980 aaatgaagag agccattgaa caggagtcac aaatgtcact aaaagatggc agaaaaaaga 2040 taaaacccac cagcgcatgg aatttggccc agaagcacaa gttaaaaacc tcattatcta 2100 atcaaccaaa acttgatgaa ctccttcagt cccaaattga aaaaagaagg agtcaaaata 2160 ttaaaatggt acagatcccc ttttctatga aaaacttaaa aataaatttt aagaaacaaa 2220 acaaagttga cttagaagag aaggatgaac cttgcttgat ccacaatctc aggtttcctg 2280 atgcatggct aatgacatcc aaaacagagg taatgttatt aaatccatat agagtagaag 2340 aagccctgct atttaaaaga cttcttgaga atcataaact tcctgcagag ccactggaaa 2400 agccaattat gttaacagag agtcttttta atggatctca ttatttagac gttttatata 2460 aaatgacagc agatgaccaa agatacagtg gatcaactta cctgtctgat cctcgtctta 2520 cagcgaatgg tttcaagata aaattgatac caggagtttc aattactgaa aattacttgg 2580 aaatagaagg aatggctaat tgtctcccat tctatggagt agcagattta aaagaaattc 2640 ttaatgctat attaaacaga aatgcaaagg aagtttatga atgtagacct cgcaaagtga 2700 taagttattt agagggagaa gcagtgcgtc tatccagaca attacccatg tacttatcaa 2760 aagaggacat ccaagacatt atctacagaa tgaagcacca gtttggaaat gaaattaaag 2820 agtgtgttca tggtcgccca ttttttcatc atttaaccta tcttccagaa actacatgag 2880 agtgtgttca tggtcgccca ttttttcatc atttaaccta tcttccagaa actacatgat 2940 taaatatgtt taagaagatt agttaccatt gaaattggtt ctgtcataaa acagcatgag 3000 tctggtttta aattatcttt gtattatgtg tcacatggtt attttttaaa tgaggattca 3060 ctgacttgtt tttatattga aaaaagttcc acgtattgta gaaaacgtaa ataaactaat 3120 a 3121 <210> 507 <211> 3063 <212> DNA <213> Homo sapiens <400> 507 ggcacgagtg gctgcttgcg gctagtggat ggtaattgcc tgcctcgcgc tagcagcaag 60 ctgctctgtt aaaagcgaaa atgaaacaat tgcctgcggc aacagttcga ctcctttcaa 120 gttctcagat catcacttcg gtggtcagtg ttgtaaaaga gcttattgaa aactccttgg 180 atgctggtgc cacaagcgta gatgttaaac tggagaacta tggatttgat aaaattgagg 240 tgcgagataa cggggagggt atcaaggctg ttgatgcacc tgtaatggca atgaagtact 300 acacctcaaa aataaatagt catgaagatc ttgaaaattt gacaacttac ggttttcgtg 360 gagaagcctt ggggtcaatt tgttgtatag ctgaggtttt aattacaaca agaacggctg 420 ctgataattt tagcacccag tatgttttag atggcagtgg ccacatactt tctcagaaac 480 cttcacatct tggtcaaggt acaactgtaa ctgctttaag attatttaag aatctacctg 540 taagaaagca gttttactca actgcaaaaa aatgtaaaga tgaaataaaa aagatccaag 600 atctcctcat gagctttggt atccttaaac ctgacttaag gattgtcttt gtacataaca 660 aggcagttat ttggcagaaa agcagagtat cagatcacaa gatggctctc atgtcagttc 720 tggggactgc tgttatgaac aatatggaat cctttcagta ccactctgaa gaatctcaga 780 tttatctcag tggatttctt ccaaagtgtg atgcagacca ctctttcact agtctttcaa 840 caccagaaag aagtttcatc ttcataaaca gtcgaccagt acatcaaaaa gatatcttaa 900 agttaatccg acatcattac aatctgaaat gcctaaagga atctactcgt ttgtatcctg 960 ttttctttct gaaaatcgat gttcctacag ctgatgttga tgtaaattta acaccagata 1020 aaagccaagt attattacaa aataaggaat ctgttttaat tgctcttgaa aatctgatga 1080 cgacttgtta tggaccatta cctagtacaa attcttatga aaataataaa acagatgttt 1140 ccgcagctga catcgttctt agtaaaacag cagaaacaga tgtgcttttt aataaagtgg 1200 aatcatctgg aaagaattat tcaaatgttg atacttcagt cattccattc caaaatgata 1260 tgcataatga tgaatctgga aaaaacactg atgattgttt aaatcaccag ataagtattg 1320 gtgactttgg ttatggtcat tgtagtagtg aaatttctaa cattgataaa aacactaaga 1380 atgcatttca ggacatttca atgagtaatg tatcatggga gaactctcag acggaatata 1440 gtaaaacttg ttttataagt tccgttaagc acacccagtc agaaaatggc aataaagacc 1500 atatagatga gagtggggaa aatgaggaag aagcaggtct tgaaaactct tcggaaattt 1560 ctgcagatga gtggagcagg ggaaatatac ttaaaaattc agtgggagag aatattgaac 1620 ctgtgaaaat tttagtgcct gaaaaaagtt taccatgtaa agtaagtaat aataattatc 1680 caatccctga acaaatgaat cttaatgaag attcatgtaa caaaaaatca aatgtaatag 1740 ataataaatc tggaaaagtt acagcttatg atttacttag caatcgagta atcaagaaac 1800 ccatgtcagc aagtgctctt tttgttcaag atcatcgtcc tcagtttctc atagaaaatc 1860 ctaagactag tttagaggat gcaacactac aaattgaaga actgtggaag acattgagtg 1920 aagaggaaaa actgaaatat gaagagaagg ctactaaaga cttggaacga tacaatagtc 1980 aaatgaagag agccattgaa caggagtcac aaatgtcact aaaagatggc agaaaaaaga 2040 taaaacccac cagcgcatgg aatttggccc agaagcacaa gttaaaaacc tcattatcta 2100 atcaaccaaa acttgatgaa ctccttcagt cccaaattga aaaaagaagg agtcaaaata 2160 ttaaaatggt acagatcccc ttttctatga aaaacttaaa aataaatttt aagaaacaaa 2220 acaaagttga cttagaagag aaggatgaac cttgcttgat ccacaatctc aggtttcctg 2280 atgcatggct aatgacatcc aaaacagagg taatgttatt aaatccatat agagtagaag 2340 aagccctgct atttaaaaga cttcttgaga atcataaact tcctgcagag ccactggaaa 2400 agccaattat gttaacagag agtcttttta atggatctca ttatttagac gttttatata 2460 aaatgacagc agatgaccaa agatacagtg gatcaactta cctgtctgat cctcgtctta 2520 cagcgaatgg tttcaagata aaattgatac caggagtttc aattactgaa aattacttgg 2580 aaatagaagg aatggctaat tgtctcccat tctatggagt agcagattta aaagaaattc 2640 ttaatgctat attaaacaga aatgcaaagg aagtttatga atgtagacct cgcaaagtga 2700 taagttattt agagggagaa gcagtgcgtc tatccagaca attacccatg tacttatcaa 2760 aagaggacat ccaagacatt atctacagaa tgaagcacca gtttggaaat gaaattaaag 2820 agtgtgttca tggtcgccca ttttttcatc atttaaccta tcttccagaa actacatgat 2880 taaatatgtt taagaagatt agttaccatt gaaattggtt ctgtcataaa acagcatgag 2940 tctggtttta aattatcttt gtattatgtg tcacatggtt attttttaaa tgaggattca 3000 ctgacttgtt tttatattga aaaaagttcc acgtattgta gaaaacgtaa ataaactaat 3060 aac 3063 <210> 508 <211> 2365 <212> DNA <213> Homo sapiens <400> 508 agcggaggct cgctgccagc ggattggctg cgagcagcgc caatctcacg ttgcccccgg 60 gcgaggcggg actcagtgcc gcgctctctg cacccgctct gccgcgcgcg tgcgtgctgg 120 gtgcgggtgc gggtgcgggg ttgggcctgc gcatcgggtg agacgctggc tgcttgcggc 180 tagtggatgg taattgcctg cctcgcgcta gcaggaagct gctctgttaa aagcgaaaat 240 gaaacaattg cctgcggcaa cagttcgact cctttcaagt tctcagatca tcacttcggt 300 ggtcagtgtt gtaaaagagc ttattgaaaa ctccttggat gctggtgcca caagcgtaga 360 tgttaaactg gagaactatg gatttgataa aattgaggtg cgagataacg gggagggtat 420 caaggctgtt gatgcacctg taatggcaat gaagtactac acctcaaaaa taaatagtca 480 tgaagatctt gaaaatttga caacttacgg ttttcgtgga gaagccttgg ggtcaatttg 540 ttgtatagct gaggttttaa ttacaacaag aacggctgct gataatttta gcacccagta 600 tgttttagat ggcagtggcc acatactttc tcagaaacct tcacatcttg gtcaaggtac 660 aactgtaact gctttaagat tatttaagaa tctacctgta agaaagcagt tttactcaac 720 tgcaaaaaaa tgtaaagatg aaataaaaaa gatccaagat ctcctcatga gctttggtat 780 ccttaaacct gacttaagga ttgtctttgt acataacaag gcagttattt ggcagaaaag 840 cagagtatca gatcacaaga tggctctcat gtcagttctg gggactgctg ttatgaacaa 900 tatggaatcc tttcagtacc actctgaaga atctcagatt tatctcagtg gatttcttcc 960 aaagtgtgat gcagaccact ctttcactag tctttcaaca ccagaaagaa gtttcatctt 1020 cataaacagt cgaccagtac atcaaaaaga tatcttaaag gtatttctag ttaatccgac 1080 atcattacaa tctgaaatgc ctaaaggaat ctactcgttt gtatcctgtt ttctttctga 1140 aaatcgatgt tcctacagct gatgttgatg taaatttaac actagataaa agccaagtat 1200 tattacaaaa taaggaatct gttttaattg ctcttgaaaa tctgatgacg acttgttatg 1260 gaccattacc tagtacaaat tcttatgaaa ataataaaac agatgtttcc gcagctgaca 1320 tcgttcttag taaaacagca gaaacagatg tgctttttaa taaagtggaa tcatctggaa 1380 agaattattc aaatgttgat acttcagtca ttccattcca aaatgatatg cataatgatg 1440 aatctggaaa aaacactgat gattgtttaa atcaccagat aagtattggt gactttggtt 1500 atggtcattg tagtagtgaa atttctaaca ttgataaaaa cactaagaat gcatttcagg 1560 acatttcaat gagtaatgta tcatgggaga actctcagac ggaatatagt aaaacttgtt 1620 ttataagttc cgttaagcac acccagtcag aaaatggcaa taaagaccat atagatgaga 1680 gtggggaaaa tgaggaagaa gcaggtcttg aaaactcttc ggaaatttct gcagatgagt 1740 ggagcagggg aaatatactt aaaaattcag tgggagagaa tattgaacct gtgaaaattt 1800 tagtgcctga aaaaagttta ccatgtaaag taagtaataa taattatcca atccctgaac 1860 aaatgaatct taatgaagat tcatgtaaca aaaaatcaaa tgtaatagat aataaatctg 1920 gaaaagttac agcttatgat ttacttagca atcgagtaat caagaaaccc atgtcagcaa 1980 gtgctctttt tgttcaagat catcgtcctc agtttctcat agaaaatcct aagactagtt 2040 tagaggatgc aacactacaa attgaagaac tgtggaagac attgagtgaa gaggaaaaac 2100 tgaaatatga agagaaggct actaaagact tggaacgata caatagtcaa atgaagagag 2160 ccattgaaca ggagtcacaa atgtcactaa aagatggcag aaaaaagata aaacccacca 2220 gcgcatggaa tttggcccag aagtacaagt taaaaacctc attatctaat caaccaaaac 2280 ttgatgaact ccttcagtcc caaattgaaa aaagaaggag tcaaaatatt aaaatggtac 2340 agatcccctt ttctatgaaa aactt 2365 <210> 509 <211> 1906 <212> DNA <213> Homo sapiens <400> 509 agtgccgcgc tctctgcacc cgctctgccg cgcgcgtgcg tgctgggtgc gggtgcgggt 60 gcggggttgg gcctgcgcat cgggtgagac gctggctgct tgcggctagt ggatggtaat 120 tgcctgcctc gcgctagcag caagctgctc tgttaaaagc gaaaatgaaa caattgcctg 180 cggcaacagt tcgactcctt tcaagttctc agatcatcac ttcggtggtc agtgttgtaa 240 aagagcttat tgaaaactcc ttggatgctg gtgccacaag cgtagatgtt aaactggaga 300 actatggatt tgataaaatt gaggtgcgag ataacgggga gggtatcaag gctgttgatg 360 cacctgtaat ggcaatgaag tactacacct caaaaataaa tagtcatgaa gatcttgaaa 420 atttgacaac ttacggtttt cgtggagaag ccttggggtc aatttgttgt atagctgagg 480 ttttaattac aacaagaacg gctgctgata attttagcac ccagtatgtt ttagatggca 540 gtggccacat actttctcag aaaccttcac atcttggtca aggtaagaaa gtagctttgt 600 atacaaacat tctttacctt ttctgtctta attgttggtt taaaaaaaaa aaagttactc 660 ggtgaataca aatatattgc tttgggcttg gtcctgataa aggctagtta acttccaagt 720 aaacattcag cctttattct agccaccaat ttcttaaata tttagaattg ttctcaaaag 780 gaactgtatg agagactgga cacttccatg gactagttac tcctctgtaa aaactaagag 840 tatttatttt accagtgctg gattaccagt gtcatcttca tatatgaaga agattaaaat 900 tttattgaaa cataaaacat aattgatttg gtaatagtgg aaataaacga taccatcaag 960 atatgattaa ataatttaaa atctatttgt taattgatgg aaaacttcaa acatgcataa 1020 gaagttactg tacttatcac tcagtttcaa taatttatca attcattgct aaagttcttt 1080 catgtaatac cctcgcccat ttcttccctt tctatattac tttgaagcaa atacgtattg 1140 tttctacttg taatgtagtt agtgttttat atacttttat gtaatattat tacattttaa 1200 ttgatatctt atgtttttta ttttatttta ttttattttc ctgagacagg gtctcactct 1260 gtcacacagg ctggactgca gtggcatcat cttggttcac tgcaacctct gcctcccagg 1320 ctcaagtgat cctcccacct cagcctcctc agtagttggg actacaggtg cataccacca 1380 cacccggcta atttttgtat ttttagtaga gacagggttt tgctgtgttg cccagctggc 1440 ctcgaactcc tgagcccaag cgatacacct gccttggcct cccagagtgc tgagattaca 1500 gatgtgagcc actgtgttca gctgataagt gtttaaattt ctctaaaaac tatttactta 1560 taaaggtaaa aaagatctct ttaggcttca gtttcacata tctcctttaa tcttttttta 1620 ataatttcta gtgatgggat gattaagaga ctattaaagc tattacctct ttagagtcat 1680 gttcaaaata attattagat ctgaaaaggg acttgtgggt tttgttgttg ttgtttatcc 1740 ttctgcttct ccaatttgtg ttgtaaattc atgtttaatt ttgtgttccc tcattacagt 1800 ttatcaaagt acattctgta tattttctgt ggtttttttc cttcagtttt aatattaaat 1860 tattggattc ttttttccaa aaaaaaaaaa aaaaaaaaaa aaaaaa 1906 <210> 510 <211> 501 <212> DNA <213> Homo sapiens <400> 510 atgaaacaat tgcctgcggc aacagttcga ctcctttcaa gttctcagat catcacttcg 60 gtggtcagtg ttgtaaaaga gcttattgaa aactccttgg atgctggtgc cacaagcgta 120 gatgttaaac tggagaacta tggatttgat aaaattgagg tgcgagataa cggggagggt 180 atcaaggctg ttgatgcacc tgtaatggca atgaagtact acacctcaaa aataaatagt 240 catgaagatc ttgaaaattt gacaacttac ggttttcgtg gagaagcctt ggggtcaatt 300 tgttgtatag ctgaggtttt aattacaaca agaacggctg ctgataattt tagcacccag 360 tatgttttag atggcagtgg ccacatactt tctcagaaac cttcacatct tggtcaaggt 420 aagaaagtag ctttgtatac aaacattctt taccttttct gtcttaattg ttggtttaaa 480 aaaaaaaaag ttactcggta g 501 <210> 511 <211> 2771 <212> DNA <213> Homo sapiens <400> 511 cgaggcggat cgggtgttgc atccatggag cgagctgaga gctcgagtac agaacctgct 60 aaggccatca aacctattga tcggaagtca gtccatcaga tttgctctgg gcaggtggta 120 ctgagtctaa gcactgcggt aaaggagtta gtagaaaaca gtctggatgc tggtgccact 180 aatattgatc taaagcttaa ggactatgga gtggatctta ttgaagtttc agacaatgga 240 tgtggggtag aagaagaaaa cttcgaaggc ttaactctga aacatcacac atctaagatt 300 caagagtttg ccgacctaac tcaggttgaa acttttggct ttcgggggga agctctgagc 360 tcactttgtg cactgagcga tgtcaccatt tctacctgcc acgcatcggc gaaggttgga 420 actcgactga tgtttgatca caatgggaaa attatccaga aaacccccta cccccgcccc 480 agagggacca cagtcagcgt gcagcagtta ttttccacac tacctgtgcg ccataaggaa 540 tttcaaagga atattaagaa ggagtatgcc aaaatggtcc aggtcttaca tgcatactgt 600 atcatttcag caggcatccg tgtaagttgc accaatcagc ttggacaagg aaaacgacag 660 cctgtggtat gcacaggtgg aagccccagc ataaaggaaa atatcggctc tgtgtttggg 720 cagaagcagt tgcaaagcct cattcctttt gttcagctgc cccctagtga ctccgtgtgt 780 gaagagtacg gtttgagctg ttcggatgct ctgcataatc ttttttacat ctcaggtttc 840 atttcacaat gcacgcatgg agttggaagg agttcaacag acagacagtt tttctttatc 900 aaccggcggc cttgtgaccc agcaaaggtc tgcagactcg tgaatgaggt ctaccacatg 960 tataatcgac accagtatcc atttgttgtt cttaacattt ctgttgattc agaatgcgtt 1020 gatatcaatg ttactccaga taaaaggcaa attttgctac aagaggaaaa gcttttgttg 1080 gcagttttaa agacctcttt gataggaatg tttgatagtg atgtcaacaa gctaaatgtc 1140 agtcagcagc cactgctgga tgttgaaggt aacttaataa aaatgcatgc agcggatttg 1200 gaaaagccca tggtagaaaa gcaggatcaa tccccttcat taaggactgg agaagaaaaa 1260 aaagacgtgt ccatttccag actgcgagag gccttttctc ttcgtcacac aacagagaac 1320 aagcctcaca gcccaaagac tccagaacca agaaggagcc ctctaggaca gaaaaggggt 1380 atgctgtctt ctagcacttc aggtgccatc tctgacaaag gcgtcctgag acctcagaaa 1440 gaggcagtga gttccagtca cggacccagt gaccctacgg acagagcgga ggtggagaag 1500 gactcggggc acggcagcac ttccgtggat tctgaggggt tcagcatccc agacacgggc 1560 agtcactgca gcagcgagta tgcggccagc tccccagggg acaggggctc gcaggaacat 1620 gtggactctc aggagaaagc gcctgaaact gacgactctt tttcagatgt ggactgccat 1680 tcaaaccagg aagataccgg atgtaaattt cgagttttgc ctcagccaac taatctcgca 1740 accccaaaca caaagcgttt taaaaaagaa gaaattcttt ccagttctga catttgtcaa 1800 aagttagtaa atactcagga catgtcagcc tctcaggttg atgtagctgt gaaaattaat 1860 aagaaagttg tgcccctgga cttttctatg agttctttag ctaaacgaat aaagcagtta 1920 catcatgaag cacagcaaag tgaaggggaa cagaattaca ggaagtttag ggcaaagatt 1980 tgtcctggag aaaatcaagc agccgaagat gaactaagaa aagagataag taaaacgatg 2040 tttgcagaaa tggaaatcat tggtcagttt aacctgggat ttataataac caaactgaat 2100 gaggatatct tcatagtgga ccagcatgcc acggacgaga agtataactt cgagatgctg 2160 cagcagcaca ccgtgctcca ggggcagagg ctcatagcac ctcagactct caacttaact 2220 gctgttaatg aagctgttct gatagaaaat ctggaaatat ttagaaagaa tggctttgat 2280 tttgttatcg atgaaaatgc tccagtcact gaaagggcta aactgatttc cttgccaact 2340 agtaaaaact ggaccttcgg accccaggac gtcgatgaac tgatcttcat gctgagcgac 2400 agccctgggg tcatgtgccg gccttcccga gtcaagcaga tgtttgcctc cagagcctgc 2460 cggaagtcgg tgatgattgg gactgctctt aacacaagcg agatgaagaa actgatcacc 2520 cacatggggg agatggacca cccctggaac tgtccccatg gaaggccaac catgagacac 2580 atcgccaacc tgggtgtcat ttctcagaac tgaccgtagt cactgtatgg aataattggt 2640 tttatcgcag atttttatgt tttgaaagac agagtcttca ctaacctttt ttgttttaaa 2700 atgaaacctg ctacttaaaa aaaatacaca tcacacccat ttaaaagtga tcttgagaac 2760 cttttcaaac c 2771 <210> 512 <211> 2697 <212> DNA <213> Homo sapiens <400> 512 ccatggagcg agctgagagc tcgagtacag aacctgctaa ggccatcaaa cctattgatc 60 ggaagtcagt ccatcagatt tgctctgggc aggtggtact gagtctaagc actgcggtaa 120 aggagttagt agaaaacagt ctggatgctg gtgccactaa tattgatcta aagcttaagg 180 actatggagt ggatcttatt gaagtttcag acaatggatg tggggtagaa gaagaaaact 240 tcgaaggctt aactctgaaa catcacacat ctaagattca agagtttgcc gacctaactc 300 aggttgaaac ttttggcttt cggggggaag ctctgagctc actttgtgca ctgagcgatg 360 tcaccatttc tacctgccac gcatcggcga aggttggaac tcgactgatg tttgatcaca 420 atgggaaaat tatccagaaa accccctacc cccgccccag agggaccaca gtcagcgtgc 480 agcagttatt ttccacacta cctgtgcgcc ataaggaatt tcaaaggaat attaagaagg 540 agtatgccaa aatggtccag gtcttacatg catactgtat catttcagca ggcatccgtg 600 taagttgcac caatcagctt ggacaaggaa aacgacagcc tgtggtatgc acaggtggaa 660 gccccagcat aaaggaaaat atcggctctg tgtttgggca gaagcagttg caaagcctca 720 ttccttttgt tcagctgccc cctagtgact ccgtgtgtga agagtacggt ttgagctgtt 780 cggatgctct gcataatctt ttttacatct caggtttcat ttcacaatgc acgcatggag 840 ttggaaggag ttcaacagac agacagtttt tctttatcaa ccggcggcct tgtgacccag 900 caaaggtctg cagactcgtg aatgaggtct accacatgta taatcgacac cagtatccat 960 ttgttgttct taacatttct gttgattcag aatgcgttga tatcaatgtt actccagata 1020 aaaggcaaat tttgctacaa gaggaaaagc ttttgttggc agttttaaag acctctttga 1080 taggaatgtt tgatagtgat gtcaacaagc taaatgtcag tcagcagcca ctgctggatg 1140 ttgaaggtaa cttaataaaa atgcatgcag cggatttgga aaagcccatg gtagaaaagc 1200 aggatcaatc cccttcatta aggactggag aagaaaaaaa agacgtgtcc atttccagac 1260 tgcgagaggc cttttctctt cgtcacacaa cagagaacaa gcctcacagc ccaaagactc 1320 cagaaccaag aaggagccct ctaggacaga aaaggggtat gctgtcttct agcacttcag 1380 gtgccatctc tgacaaaggc gtcctgagat ctcagaaaga ggcagtgagt tccagtcacg 1440 gacccagtga ccctacggac agagcggagg tggagaagga ctcggggcac ggcagcactt 1500 ccgtggattc tgaggggttc agcatcccag acacgggcag tcactgcagc agcgagtatg 1560 cggccagctc cccaggggac aggggctcgc aggaacatgt ggactctcag gagaaagcgc 1620 ctgaaactga cgactctttt tcagatgtgg actgccattc aaaccaggaa gataccggat 1680 gtaaatttcg agttttgcct cagccaacta atctcgcaac cccaaacaca aagcgtttta 1740 aaaaagaaga aattctttcc agttctgaca tttgtcaaaa gttagtaaat actcaggaca 1800 tgtcagcctc tcaggttgat gtagctgtga aaattaataa gaaagttgtg cccctggact 1860 tttctatgag ttctttagct aaacgaataa agcagttaca tcatgaagca cagcaaagtg 1920 aaggggaaca gaattacagg aagtttaggg caaagatttg tcctggagaa aatcaagcag 1980 ccgaagatga actaagaaaa gagataagta aaacgatgtt tgcagaaatg gaaatcattg 2040 gtcagtttaa cctgggattt ataataacca aactgaatga ggatatcttc atagtggacc 2100 agcatgccac ggacgagaag tataacttcg agatgctgca gcagcacacc gtgctccagg 2160 ggcagaggct catagcacct cagactctca acttaactgc tgttaatgaa gctgttctga 2220 tagaaaatct ggaaatattt agaaagaatg gctttgattt tgttatcgat gaaaatgctc 2280 cagtcactga aagggctaaa ctgatttcct tgccaactag taaaaactgg accttcggac 2340 cccaggacgt cgatgaactg atcttcatgc tgagcgacag ccctggggtc atgtgccggc 2400 cttcccgagt caagcagatg tttgcctcca gagcctgccg gaagtcggtg atgattggga 2460 ctgctctcaa cacaagcgag atgaagaaac tgatcaccca catgggggag atggaccacc 2520 cctggaactg tccccatgga aggccaacca tgagacacat cgccaacctg ggtgtcattt 2580 ctcagaactg accgtagtca ctgtatggaa taattggttt tatcgcagat ttttatgttt 2640 tgaaagacag agtcttcact aacctttttt gttttaaaat gaaacctgcg gccttcg 2697 <210> 513 <211> 2779 <212> DNA <213> Homo sapiens <400> 513 gtgggagccc tggagggaac tttcccagtc cccgaggcgg atcgggtgtt gcatccatgg 60 agcgagctga gagctcgaga acctgctaag gccatcaaac ctattgatcg gaagtcagtc 120 catcagattt gctctgggca ggtggtactg agtctaagca ctgcggtaaa ggagttagta 180 gaaaacagtc tggatgctgg tgccactaat attgatctaa agcttaagga ctatggagtg 240 gatcttattg aagtttcaga caatggatgt ggggtagaag aagaaaactt cgaaggctta 300 actctgaaac atcacacatc taagattcaa gagtttgccg acctaactca ggttgaaact 360 tttggctttc ggggggaagc tctgagctca ctttgtgcac tgagcgatgt caccatttct 420 acctgccacg catcggcgaa ggttggaact cgactgatgt ttgatcacaa tgggaaaatt 480 atccagaaaa ccccctaccc ccgccccaga gggaccacag tcagcgtgca gcagttattt 540 tccacactac ctgtgcgcca taaggaattt caaaggaata ttaagaagga gtatgccaaa 600 atggtccagg tcttacatgc atactgtatc atttcagcag gcatccgtgt aagttgcacc 660 aatcagcttg gacaaggaaa acgacagcct gtggtatgca caggtggaag ccccagcata 720 aaggaaaata tcggctctgt gtttgggcag aagcagttgc aaagcctcat tccttttgtt 780 cagctgcccc ctagtgactc cgtgtgtgaa gagtacggtt tgagctgttc ggatgctctg 840 cataatcttt tttacatctc aggtttcatt tcacaatgca cgcatggagt tggaaggagt 900 tcaacagaca gacagttttt ctttatcaac cggcggcctt gtgacccagc aaaggtctgc 960 agactcgtga atgaggtcta ccacatgtat aatcgacacc agtatccatt tgttgttctt 1020 aacatttctg ttgattcaga atgcgttgat atcaatgtta ctccagataa aaggcaaatt 1080 ttgctacaag aggaaaagct tttgttggca gttttaaaga cctctttgat aggaatgttt 1140 gatagtgatg tcaacaagct aaatgtcagt cagcagccac tgctggatgt tgaaggtaac 1200 ttaataaaaa tgcatgcagc ggatttggaa aagcccatgg tagaaaagca ggatcaatcc 1260 ccttcattaa ggactggaga agaaaaaaaa gacgtgtcca tttccagact gcgagaggcc 1320 ttttctcttc gtcacacaac agagaacaag cctcacagcc caaagactcc agaaccaaga 1380 aggagccctc taggacagaa aaggggtatg ctgtcttcta gcacttcagg tgccatctct 1440 gacaaaggcg tcctgagacc tcagaaagag gcagtgagtt ccagtcacgg acccagtgac 1500 cctacggaca gagcggaggt ggagaaggac tcggggcatg gcagcacttc cgtggattct 1560 gaggggttca gcatcccaga cacgggcagt cactgcagca gcgagtatgc ggccagctcc 1620 ccaggggaca ggggctcgca ggaacatgtg gactctcagg agaaagcgcc tgaaactgac 1680 gactcttttt cagatgtgga ctgccattca aaccaggaag ataccggatg taaatttcga 1740 gttttgcctc agccaactaa tctcgcaacc ccaaacacaa agcgttttaa aaaagaagaa 1800 attctttcca gttctgacat ttgtcaaaag ttagtaaata ctcaggacat gtcagcctct 1860 caggttgatg tagctgtgaa aattaataag aaagttgtgc ccctggactt ttctatgagt 1920 tctttagcta aacgaataaa gcagttacat catgaagcac agcaaagtga aggggaacag 1980 aattacagga agtttagggc aaagatttgt cctggagaaa atcaagcagc cgaagatgaa 2040 ctaagaaaag agataagtaa aacgatgttt gcagaaatgg aaatcattgg tcagtttaac 2100 ctgggattta taataaccaa actgaatgag gatatcttca tagtggacca gcatgccacg 2160 gacgagaagt ataacttcga gatgctgcag cagcacaccg tgctccaggg gcagaggctc 2220 atagcacctc agactctcaa cttaactgct gttaatgaag ctgttctgat agaaaatctg 2280 gaaatattta gaaagaatgg ctttgatttt gttatcgatg aaaatgctcc agtcactgaa 2340 agggctaaac tgatttcctt gccaactagt aaaaactgga ccttcggacc ccaggacgtc 2400 gatgaactga tcttcatgct gagcgacagc cctggggtca tgtgccggcc ttcccgagtc 2460 aagcagatgt ttgcctccag agcctgccgg aagtcggtga tgattgggac tgctcttaac 2520 acaagcgaga tgaagaaact gatcacccac atgggggaga tggaccaccc ctggaactgt 2580 ccccatggaa ggccaaccat gagacacatc gccaacctgg gtgtcatttc tcagaactga 2640 ccgtagtcac tgtatggaat aattggtttt atcgcagatt tttatgtttt gaaagacaga 2700 gtcttcacta accttttttg ttttaaaatg aacctgctac ttaaaaaaaa tacacatcac 2760 acccaaaaaa aaaaaaaaa 2779 <210> 514 <211> 1849 <212> DNA <213> Homo sapiens <400> 514 ggagggaact ttcccagtcc ccgaggcgga tcgggtgttg catccatgga gcgagctgag 60 agctcgagta cagaacctgc taaggccatc aaacctattg atcggaagtc agtccatcag 120 atttgctctg ggcaggtggt actgagtcta agcactgcgg taaaggagtt agtagaaaac 180 agtctggatg ctggtgccac taatattgat ctaaagctta aggactatgg agtggatctt 240 attgaagttt cagacaatgg atgtggggta gaagaagaaa acttcgaagg cttaactctg 300 aaacatcaca catctaagat tcaagagttt gccgacctaa ctcaggttga aacttttggc 360 tttcgggggg aagctctgag ctcactttgt gcactgagcg atgtcaccat ttctacctgc 420 cacgcatcgg cgaaggttgg aactcgactg atgtttgatc acaatgggaa aattatccag 480 aaaaccccct acccccgccc cagagggacc acagtcagcg tgcagcagtt attttccaca 540 ctacctgtgc gccataagga atttcaaagg aatattaaga aggagtatgc caaaatggtc 600 caggtcttac atgcatactg tatcatttca gcaggcatcc gtgtaagttg caccaatcag 660 cttggacaag gaaaacgaca gcctgtggta tgcacaggtg gaagccccag cataaaggaa 720 aatatcggct ctgtgtttgg gcagaagcag ttgcaaagcc tcattccttt tgttcagctg 780 ccccctagtg actccgtgtg tgaagagtac ggtttgagct gttcggatgc tctgcataat 840 cttttttaca tctcaggttt catttcacaa tgcacgcatg gagttggaag gagttcaaca 900 gacagacagt ttttctttat caaccggcgg ccttgtgacc cagcaaaggt ctgcagactc 960 gtgaatgagg tctaccacat gtataatcga caccagtatc catttgttgt tcttaacatt 1020 tctgttgatt cagaatgcgt tgatatcaat gttactccag ataaaaggca aattttgcta 1080 caagaggaaa agcttttgtt ggcagtttta aagacctctt tgataggaat gtttgatagt 1140 gatgtcaaca agctaaatgt cagtcagcag ccactgctgg atgttgaagg taacttaata 1200 aaaatgcatg cagcggattt ggaaaagccc atggtagaaa agcaggatca atccccttca 1260 ttaaggactg gagaagaaaa aaaagacgtg tccatttcca gactgcgaga ggccttttct 1320 cttcgtcaca caacagagaa caagcctcac agcccaaaga ctccagaacc aagaaggagc 1380 cctctaggac agaaaagggg tatgctgtct tctagcactt caggtgccat ctctgacaaa 1440 ggcgtcctga gacctcagaa agaggcagtg agttccagtc acggacccag tgaccctacg 1500 gacagagcgg aggtggagaa ggactcgggg cacggcagca cttccgtgga ttctgagggg 1560 ttcagcatcc cagacacggg cagtcactgc agcagcgagt atgcggccag ctccccaggg 1620 gacaggggct cgcaggaaca tgtggactct caggagaaag cgcctgaaac tgacgactct 1680 ttttcagatg tggactgcca ttcaaaccag gaagataccg gatgtaaatt tcgagttttg 1740 cctcagccaa ctaatctcgc aaccccaaac acaaagcgtt ttaaaaaaga agaaattctt 1800 tccagttctg acatttgtca aaaaaaaaaa aaaaaaaaaa aaaagaaaa 1849 <210> 515 <211> 1716 <212> DNA <213> Homo sapiens <400> 515 atggctgcag gcccggcccg ggcccctcag gagcagaaca gccttggtga ggtggacaag 60 aggggacctc gcgagcagac gcgcgccagc gacagcagcc ccgccccggc ctctggggag 120 ccccaggagg gtctaccagc cacagtctct gcacgtttcc aagagcagca gaaaatgaac 180 acattgcagg tctgcagact cgtgaatgac gtctaccgcg tgtataatcg acaccagtat 240 ccatttgttg ttcttaacat ttctgttgat tcaggtaact taataaaaat gcatgcagcg 300 gatttggaaa agcccatggt agaaaagcag gatcaatccc cttcattaag gactggagaa 360 gaaaaaaggg acgtgtccat ttccagactg cgagaggcct tttctcttcg tcacacaaca 420 gagaacaagc ctcacagccc aaagactcca gaaccaagaa ggagccctct aggacagaaa 480 aggggtatgt cgtcttctag cacttcagat gccatctctg acaaaggcgt cctgagacct 540 cagaaagagg cagtgagttc cagtcaggga cccagtgacc ctacggacag agcggaggtg 600 gagaaggact cggggcatgg cagcacttcc gtggattctg aggggttcag catcccagac 660 acgggcagtc actgcagcag cgagtgtgtg gccagcaccc caggggacag gggctcgcag 720 gaacatgtgg actctcagga gaaagcgcct gaaactgacg actctttttc agatgtggac 780 tgccattcaa accaggaaga taccggatgt aaatttcagg ttttgcctca gccaactaat 840 ctcacatccc caaacacaaa aggttttaag aaagaagaaa ttctttccaa ttctgacatt 900 cgtcaaaagt tagtaaatac tcagaacgtg tcagcttctc aggttgatgt agctgtgaaa 960 attaataaga aagttgtgcc cctgaacttt ttgagttctt tagctaaacg aataaagcag 1020 ttacatcatg aagcacagca aagtgaaggg gaacagaatt acaggaagtt tagggcaagg 1080 atttgtcctg gagaaaatca agcagccgaa gatgaactaa gaaaagagat aagtaaaacg 1140 atgtttgcag aaatggaaat cattggtcag tttaacctgg gatttataat aaccaaactg 1200 aatgaggata tcttcatagt ggaccagcat gccacggacg agaagtataa cttcgagatg 1260 ctgcagcagc acaccgtgct ccaggggcag aggctcatag cacctcagac tctcaactta 1320 actgctgtta atgaagctgt tctgatagaa aatctggaaa tatttagaaa gaatggcttc 1380 gattttgtta tcgatgaaaa tgctccagtc actgaaaggg ctaaactgat ttccttgcca 1440 actagtaaaa gctggacctt cggaccccag gacgtcgatg aactgatctt catgctgagc 1500 gacagccctg gggtcatgtg ccggccttcc cgagtcaagc agatgtttgc ctccagagcc 1560 tgccggaagt cggtgatgat tgggactgct cttaacacaa gcgagatgaa gaaactgatc 1620 acccacatgg gggagatgga ccacccctgg aactgtcccc atggaaggcc aaccatgaga 1680 cacatcgcca acctgggtgt catttctcag aactga 1716 <210> 516 <211> 1738 <212> DNA <213> Homo sapiens <400> 516 gtctgcagac tcgtgaatga cgtctaccgc gtgtataatc gacaccagta tccatttgtt 60 gttcttaaca tttctgttga ttcaggtaac ttaataaaaa tgcatgcagc ggatttggaa 120 aagcccatgg tagaaaagca ggatcaatcc ccttcattaa ggactggaga agaaaaaagg 180 gacgtgtcca tttccagact gcgagaggcc ttttctcttc gtcacacaac agagaacaag 240 cctcacagcc caaagactcc agaaccaaga aggagccctc taggacagaa aaggggtatg 300 tcgtcttcta gcacttcaga tgccatctct gacaaaggcg tcctgagacc tcagaaagag 360 gcagtgagtt ccagtcaggg acccagtgac cctacggaca gagcggaggt ggagaaggac 420 tcggggcatg gcagcacttc cgtggattct gaggggttca gcatcccaga cacgggcagt 480 cactgcagca gcgagtgtgt ggccagcacc ccaggggaca ggggctcgca ggaacatgtg 540 gactctcagg agaaagcgcc tgaaactgac gactcttttt cagatgtgga ctgccattca 600 aaccaggaag ataccggatg taaatttcag gttttgcctc agccaactaa tctcacatcc 660 ccaaacacaa aagtgtttta agaaagaaga aattctttcc aattctgaca ttcgtcaaaa 720 gttagtaaat actcagaacg tgtcagcttc tcaggttgat gtagctgtga aaattaataa 780 gaaagttgtg cccctgaact tttctgagtt ctttagctaa acgaataaag cagttacatc 840 atgaagcaca gcaaagtgaa ggggaacaga attacaggaa gtttagggca aggatttgtc 900 ctggagaaaa tcaagcagcc gaagatgaac taagaaaaga gataagtaaa acgatgtttg 960 cagaaatgga aatcattggt cagtttaacc tgggatttat aataaccaaa ctgaatgagg 1020 atatcttcat agtggaccag catgccacgg acgagaagta taacttcgag atgctgcagc 1080 agcacaccgt gctccagggg cagaggctca tagcacctca gactctcaac ttaactgctg 1140 ttaatgaagc tgttctgata gaaaatctgg aaatatttag aaagaatggc ttcgattttg 1200 ttatcgatga aaatgctcca gtcactgaaa gggctaaact gatttccttg ccaactagta 1260 aaagctggac cttcggaccc caggacgtcg atgaactgat cttcatgctg agcgacagcc 1320 ctggggtcat gtgccggcct tcccgagtca agcagatgtt tgcctccaga gcctgccgga 1380 agtcggtgat gattgggact gctcttaaca caagcgagat gaagaaactg atcacccaca 1440 tgggggagat ggaccacccc tggaactgtc cccatggaag gccaaccatg agacacatcg 1500 ccaacctggg tgtcatttct cagaactgac cgtagtcact gtatggaata attggtttta 1560 tcgcagattt ttatgttttg aaagacagag tcttcactaa ccttttttgt tttaaaatga 1620 aacctgctac ttaaaaaaaa tacacatcac acccatttaa aagtgatctt gagaaccttt 1680 tcaaaccaga tggagcattg cttgcaaatt ttttttctct atgtttgcat gcgctcgt 1738 <210> 517 <211> 4895 <212> DNA <213> Homo sapiens <400> 517 gtcggcgtcc gaggcggttg gtgtcggaga atttgttaag cgggactcca ggcaattatt 60 tccagtcaga gaaggaaacc agtgcctggc attctcacca tctttctacc taccatgatc 120 aagtgcttgt cagttgaagt acaagccaaa ttgcgttctg gtttggccat aagctccttg 180 ggccaatgtg ttgaggaact tgccctcaac agtattgatg ctgaagcaaa atgtgtggct 240 gtcagggtga atatggaaac cttccaagtt caagtgatag acaatggatt tgggatgggg 300 agtgatgatg tagagaaagt gggaaatcgt tatttcacca gtaaatgcca ctcggtacag 360 gacttggaga atccaaggtt ttatggtttc cgaggagagg ccttggcaaa tattgctgac 420 atggccagtg ctgtggaaat ttcgtccaag aaaaacagga caatgaaaac ttttgtgaaa 480 ctgtttcaga gtggaaaagc cctgaaagct tgtgaagctg atgtgactag agcaagcgct 540 gggactactg taacagtgta taacctattt taccagcttc ctgtaaggag gaaatgcatg 600 gaccctagac tggagtttga gaaggttagg cagagaatag aagctctctc actcatgcac 660 ccttccattt ctttctcttt gagaaatgat gtttctggtt ccatggttct tcagctccct 720 aaaaccaaag acgtatgttc ccgattttgt caaatttatg gattgggaaa gtcccaaaag 780 ctaagagaaa taagttttaa atataaagag tttgagctta gtggctatat cagctctgaa 840 gcacattaca acaagaatat gcagtttttg tttgtgaaca aaagactagt tttaaggaca 900 aagctacata aactcattga ctttttatta aggaaagaaa gtattatatg caagccaaag 960 aatggtccca ccagtaggca aatgaattca agtcttcggc accggtctac cccagaactc 1020 tatggcatat atgtaattaa tgtgcagtgc caattctgtg agtatgatgt gtgcatggag 1080 ccagccaaaa ctctgattga atttcagaac tgggacactc tcttgttttg cattcaggaa 1140 ggagtgaaaa tgtttttaaa gcaagaaaaa ttatttgtgg aattatcagg tgaggatatt 1200 aaggaattta gtgaagataa tggttttagt ttatttgatg ctactcttca gaagcgtgtg 1260 acttccgatg agaggagcaa tttccaggaa gcatgtaata atattttaga ttcctatgag 1320 atgtttaatt tgcagtcaaa agctgtgaaa agaaaaacta ctgcagaaaa cgtaaacaca 1380 cagagttcta gggattcaga agctaccaga aaaaatacaa atgatgcatt tttgtacatt 1440 tatgaatcag gtggtccagg ccatagcaaa atgacagagc catctttaca aaacaaagac 1500 agctcttgct cagaatcaaa gatgttagaa caagagacaa ttgtagcatc agaagctggt 1560 gaaaatgaga aacataaaaa atctttcctg gaacgtagct ctttagaaaa tccgtgtgga 1620 accagtttag aaatgttttt aagccctttt cagacaccat gtcactttga ggagagtggg 1680 caggatctag aaatatggaa agaaagtact actgttaatg gcatggctgc caacatcttg 1740 aaaaataata gaattcagaa tcaaccaaag agatttaaag atgctactga agtgggatgc 1800 cagcctctgc cttttgcaac aacattatgg ggagtacata gtgctcagac agagaaagag 1860 aaaaaaaaag aatctagcaa ttgtggaaga agaaatgttt ttagttatgg gcgagttaaa 1920 ttatgttcca ctggctttat aactcatgta gtacaaaatg aaaaaactaa atcaactgaa 1980 acagaacatt catttaaaaa ttatgttaga cctggtccca cacgtgccca agaaacattt 2040 ggaaatagaa cacgtcattc agttgaaact ccagacatca aagatttagc cagcacttta 2100 agtaaagaat ctggtcaatt gcccaacaaa aaaaattgca gaacgaatat aagttatggg 2160 ctagagaatg aacctacagc aacttataca atgttttctg cttttcagga aggtagcaaa 2220 aaatcacaaa cagattgcat attatctgat acatccccct ctttcccctg gtatagacac 2280 gtttccaatg atagtaggaa aacagataaa ttaattggtt tctccaaacc aatcgtccgt 2340 aagaagctaa gcttgagttc acagctagga tctttagaga agtttaagag gcaatatggg 2400 aaggttgaaa atcctctgga tacagaagta gaggaaagta atggagtcac taccaatctc 2460 agtcttcaag ttgaacctga cattctgctg aaggacaaga accgcttaga gaactctgat 2520 gtttgtaaaa tcactactat ggagcatagt gattcagata gtagttgtca accagcaagc 2580 cacatccttg actcagagaa gtttccattc tccaaggatg aagattgttt agaacaacag 2640 atgcctagtt tgagagaaag tcctatgacc ctgaaggagt tatctctctt taatagaaaa 2700 cctttggacc ttgagaagtc atctgaatca ctagcctcta aattatccag actgaagggt 2760 tccgaaagag aaactcaaac aatggggatg atgagtcgtt ttaatgaact tccaaattca 2820 gattccagta ggaaagacag caagttgtgc agtgtgttaa cacaagattt ttgtatgtta 2880 tttaacaaca agcatgaaaa aacagagaat ggtgtcatcc caacatcaga ttctgccaca 2940 caggataatt cctttaataa aaatagtaaa acacattcta acagcaatac aacagagaac 3000 tgtgtgatat cagaaactcc tttggtattg ccctataata attctaaagt taccggtaaa 3060 gattcagatg ttcttatcag agcctcagaa caacagatag gaagtcttga ctctcccagt 3120 ggaatgttaa tgaatccggt agaagatgcc acaggtgacc aaaatggaat ttgttttcag 3180 agtgaggaat ctaaagcaag agcttgttct gaaactgaag agtcaaacac gtgttgttca 3240 gattggcagc ggcatttcga tgtagccctg ggaagaatgg tttatgtcaa caaaatgact 3300 ggactcagca cattcattgc cccaactgag gacattcagg ctgcttgtac taaagacctg 3360 acaactgtgg ctgtggatgt tgtacttgag aatgggtctc agtacaggtg tcaacctttt 3420 agaagcgacc ttgttcttcc tttccttccg agagctcgag cagagaggac tgtgatgaga 3480 caggataaca gagatactgt ggatgatact gttagtagcg aatcgcttca gtctttgttc 3540 tcagaatggg acaatccagt atttgcccgt tatccagagg ttgctgttga tgtaagcagt 3600 ggccaggctg agagcttagc agttaaaatt cacaacatct tgtatcccta tcgtttcacc 3660 aaaggaatga ttcattcaat gcaggttctc cagcaagtag ataacaagtt tattgcctgt 3720 ttgatgagca ctaagactga agagaatggc gaggcagatt cctacgagaa gcaacaggca 3780 caaggctctg gtcggaaaaa attactgtct tctactctaa ttcctccgct agagataaca 3840 gtgacagagg aacaaaggag actcttatgg tgttaccaca aaaatctgga agatctgggc 3900 cttgaatttg tatttccaga cactagtgat tctctggtcc ttgtgggaaa agtaccacta 3960 tgttttgtgg aaagagaagc caatgaactt cggagaggaa gatctactgt gaccaagagt 4020 attgtggagg aatttatccg agaacaactg gagctactcc agaccaccgg aggcatccaa 4080 gggacattgc cactgactgt ccagaaggtg ttggcatccc aagcctgcca tggggccatt 4140 aagtttaatg atggcctgag cttacaggaa agttgccgcc ttattgaagc tctgtcctca 4200 tgccagctgc cattccagtg tgctcacggg agaccttcta tgctgccgtt agctgacata 4260 gaccacttgg aacaggaaaa acagattaaa cccaacctca ctaaacttcg caaaatggcc 4320 caggcctggc gtctctttgg aaaagcagag tgtgatacaa ggcagagcct gcagcagtcc 4380 atgcctccct gtgagccacc atgagaacag aatcactggt ctaaaaggaa caaagggatg 4440 ttcactgtat gcctctgagc agagagcagc agcagcaggt accagcacgg ccctgactga 4500 atcagcccag tgtccctgag cagcttagac agcagggctc tctgtatcag tctttcttga 4560 gcagatgatt cccctagttg agtagccaga tgaaattcaa gcctaaagac aattcattca 4620 tttgcatcca tgggcacaga aggttgctat atagtatcta ccttttgcta cttatttaat 4680 gataaaattt aatgacagtt taaaaaaaaa aaaaaaaaaa attatttgaa ggggtgggtg 4740 atttttgttt ttgtacagtt ttttttcaag cttcacattt gcgtgtatct aattcagctg 4800 atgctcaagt ccaaggggta gtctgccttc ccaggctgcc cccagggttt ctgcactggt 4860 cccctctttt cccttcagtc ttcttcactt ccctt 4895 <210> 518 <211> 4895 <212> DNA <213> Homo sapiens <400> 518 gtcggcgtcc gaggcggttg gtgtcggaga atttgttaag cgggactcca ggcaattatt 60 tccagtcaga gaaggaaacc agtgcctggc attctcacca tctttctacc taccatgatc 120 aagtgcttgt cagttgaagt acaagccaaa ttgcgttctg gtttggccat aagctccttg 180 ggccaatgtg ttgaggaact tgccctcaac agtattgatg ctgaagcaaa atgtgtggct 240 gtcagggtga atatggaaac cttccaagtt caagtgatag acaatggatt tgggatgggg 300 agtgatgatg tagagaaagt gggaaatcgt tatttcacca gtaaatgcca ctcggtacag 360 gacttggaga atccaaggtt ttatggtttc cgaggagagg ccttggcaaa tattgctgac 420 atggccagtg ctgtggaaat ttcgtccaag aaaaacagga caatgaaaac ttttgtgaaa 480 ctgtttcaga gtggaaaagc cctgaaagct tgtgaagctg atgtgactag agcaagcgct 540 gggactactg taacagtgta taacctattt taccagcttc ctgtaaggag gaaatgcatg 600 gaccctagac tggagtttga gaaggttagg cagagaatag aagctctctc actcatgcac 660 ccttccattt ctttctcttt gagaaatgat gtttctggtt ccatggttct tcagctccct 720 aaaaccaaag acgtatgttc ccgattttgt caaatttatg gattgggaaa gtcccaaaag 780 ctaagagaaa taagttttaa atataaagag tttgagctta gtggctatat cagctctgaa 840 gcacattaca acaagaatat gcagtttttg tttgtgaaca aaagactagt tttaaggaca 900 aagctacata aactcattga ctttttatta aggaaagaaa gtattatatg caagccaaag 960 aatggtccca ccagtaggca aatgaattca agtcttcggc accggtctac cccagaactc 1020 tatggcatat atgtaattaa tgtgcagtgc caattctgtg agtatgatgt gtgcatggag 1080 ccagccaaaa ctctgattga atttcagaac tgggacactc tcttgttttg cattcaggaa 1140 ggagtgaaaa tgtttttaaa gcaagaaaaa ttatttgtgg aattatcagg tgaggatatt 1200 aaggaattta gtgaagataa tggttttagt ttatttgatg ctactcttca gaagcgtgtg 1260 acttccgatg agaggagcaa tttccaggaa gcatgtaata atattttaga ttcctatgag 1320 atgtttaatt tgcagtcaaa agctgtgaaa agaaaaacta ctgcagaaaa cgtaaacaca 1380 cagagttcta gggattcaga agctaccaga aaaaatacaa atgatgcatt tttgtacatt 1440 tatgaatcag gtggtccagg ccatagcaaa atgacagagc catctttaca aaacaaagac 1500 agctcttgct cagaatcaaa gatgttagaa caagagacaa ttgtagcatc agaagctggt 1560 gaaaatgaga aacataaaaa atctttcctg gaacgtagct ctttagaaaa tccgtgtgga 1620 accagtttag aaatgttttt aagccctttt cagacaccat gtcactttga ggagagtggg 1680 caggatctag aaatatggaa agaaagtact actgttaatg gcatggctgc caacatcttg 1740 aaaaataata gaattcagaa tcaaccaaag agatttaaag atgctactga agtgggatgc 1800 cagcctctgc cttttgcaac aacattatgg ggagtacata gtgctcagac agagaaagag 1860 aaaaaaaaag aatctagcaa ttgtggaaga agaaatgttt ttagttatgg gcgagttaaa 1920 ttatgttcca ctggctttat aactcatgta gtacaaaatg aaaaaactaa atcaactgaa 1980 acagaacatt catttaaaaa ttatgttaga cctggtccca cacgtgccca agaaacattt 2040 ggaaatagaa cacgtcattc agttgaaact ccagacatca aagatttagc cagcacttta 2100 agtaaagaat ctggtcaatt gcccaacaaa aaaaattgca gaacgaatat aagttatggg 2160 ctagagaatg aacctacagc aacttataca atgttttctg cttttcagga aggtagcaaa 2220 aaatcacaaa cagattgcat attatctgat acatccccct ctttcccctg gtatagacac 2280 gtttccaatg atagtaggaa aacagataaa ttaattggtt tctccaaacc aatcgtccgt 2340 aagaagctaa gcttgagttc acagctagga tctttagaga agtttaagag gcaatatggg 2400 aaggttgaaa atcctctgga tacagaagta gaggaaagta atggagtcac taccaatctc 2460 agtcttcaag ttgaacctga cattctgctg aaggacaaga accgcttaga gaactctgat 2520 gtttgtaaaa tcactactat ggagcatagt gattcagata gtagttgtca accagcaagc 2580 cacatccttg actcagagaa gtttccattc tccaaggatg aagattgttt agaacaacag 2640 atgcctagtt tgagagaaag tcctatgacc ctgaaggagt tatctctctt taatagaaaa 2700 cctttggacc ttgagaagtc atctgaatca ctagcctcta aattatccag actgaagggt 2760 tccgaaagag aaactcaaac aatggggatg atgagtcgtt ttaatgaact tccaaattca 2820 gattccagta ggaaagacag caagttgtgc agtgtgttaa cacaagattt ttgtatgtta 2880 tttaacaaca agcatgaaaa aacagagaat ggtgtcatcc caacatcaga ttctgccaca 2940 caggataatt cctttaataa aaatagtaaa acacattcta acagcaatac aacagagaac 3000 tgtgtgatat cagaaactcc tttggtattg ccctataata attctaaagt taccggtaaa 3060 gattcagatg ttcttatcag agcctcagaa caacagatag gaagtcttga ctctcccagt 3120 ggaatgttaa tgaatccggt agaagatgcc acaggtgacc aaaatggaat ttgttttcag 3180 agtgaggaat ctaaagcaag agcttgttct gaaactgaag agtcaaacac gtgttgttca 3240 gattggcagc ggcatttcga tgtagccctg ggaagaatgg tttatgtcaa caaaatgact 3300 ggactcagca cattcattgc cccaactgag gacattcagg ctgcttgtac taaagacctg 3360 acaactgtgg ctgtggatgt tgtacttgag aatgggtctc agtacaggtg tcaacctttt 3420 agaagcgacc ttgttcttcc tttccttccg agagctcgag cagagaggac tgtgatgaga 3480 caggataaca gagatactgt ggatgatact gttagtagcg aatcgcttca gtctttgttc 3540 tcagaatggg acaatccagt atttgcccgt tatccagagg ttgctgttga tgtaagcagt 3600 ggccaggctg agagcttagc agttaaaatt cacaacatct tgtatcccta tcgtttcacc 3660 aaaggaatga ttcattcaat gcaggttctc cagcaagtag ataacaagtt tattgcctgt 3720 ttgatgagca ctaagactga agagaatggc gaggcagatt cctacgagaa gcaacaggca 3780 caaggctctg gtcggaaaaa attactgtct tctactctaa ttcctccgct agagataaca 3840 gtgacagagg aacaaaggag actcttatgg tgttaccaca aaaatctgga agatctgggc 3900 cttgaatttg tatttccaga cactagtgat tctctggtcc ttgtgggaaa agtaccacta 3960 tgttttgtgg aaagagaagc caatgaactt cggagaggaa gatctactgt gaccaagagt 4020 attgtggagg aatttatccg agaacaactg gagctactcc agaccaccgg aggcatccaa 4080 gggacattgc cactgactgt ccagaaggtg ttggcatccc aagcctgcca tggggccatt 4140 aagtttaatg atggcctgag cttacaggaa agttgccgcc ttattgaagc tctgtcctca 4200 tgccagctgc cattccagtg tgctcacggg agaccttcta tgctgccgtt agctgacata 4260 gaccacttgg aacaggaaaa acagattaaa cccaacctca ctaaacttcg caaaatggcc 4320 caggcctggc gtctctttgg aaaagcagag tgtgatacaa ggcagagcct gcagcagtcc 4380 atgcctccct gtgagccacc atgagaacag aatcactggt ctaaaaggaa caaagggatg 4440 ttcactgtat gcctctgagc agagagcagc agcagcaggt accagcacgg ccctgactga 4500 atcagcccag tgtccctgag cagcttagac agcagggctc tctgtatcag tctttcttga 4560 gcagatgatt cccctagttg agtagccaga tgaaattcaa gcctaaagac aattcattca 4620 tttgcatcca tgggcacaga aggttgctat atagtatcta ccttttgcta cttatttaat 4680 gataaaattt aatgacagtt taaaaaaaaa aaaaaaaaaa attatttgaa ggggtgggtg 4740 atttttgttt ttgtacagtt ttttttcaag cttcacattt gcgtgtatct aattcagctg 4800 atgctcaagt ccaaggggta gtctgccttc ccaggctgcc cccagggttt ctgcactggt 4860 cccctctttt cccttcagtc ttcttcactt ccctt 4895 <210> 519 <211> 4362 <212> DNA <213> Homo sapiens <400> 519 atgatcaagt gcttgtcagt tgaagtacaa gccaaattgc gttctggttt ggccataagc 60 tccttgggcc aatgtgttga ggaacttgcc ctcaacagta ttgatgctga agcaaaatgt 120 gtggctgtca gggtgaatat ggaaaccttc caagttcaag tgatagacaa tggatttggg 180 atggggagtg atgatgtaga gaaagtggga aatcgttatt tcaccagtaa atgccactcg 240 gtacaggact tggagaatcc aaggttttat ggtttccgag gagaggcctt ggcaaatatt 300 gctgacatgg ccagtgctgt ggaaatttcg tccaagaaaa acaggacaat gaaaactttt 360 gtgaaactgt ttcagagtgg aaaagccctg aaagcttgtg aagctgatgt gactagagca 420 agcgctggga ctactgtaac agtgtataac ctattttacc agcttcctgt aaggaggaaa 480 tgcatggacc ctagactgga gtttgagaag gttaggcaga gaatagaagc tctctcactc 540 atgcaccctt ccatttcttt ctctttgaga aatgatgttt ctggttccat ggttcttcag 600 ctccctaaaa ccaaagacgt atgttcccga ttttgtcaaa tttatggatt gggaaagtcc 660 caaaagctaa gagaaataag ttttaaatat aaagagtttg agcttagtgg ctatatcagc 720 tctgaagcac attacaacaa gaatatgcag tttttgtttg tgaacaaaag actagtttta 780 aggacaaagc tacataaact cattgacttt ttattaagga aagaaagtat tatatgcaag 840 ccaaagaatg gtcccaccag taggcaaatg aattcaagtc ttcggcaccg gtctacccca 900 gaactctatg gcatatatgt aattaatgtg cagtgccaat tctgtgagta tgatgtgtgc 960 atggagccag ccaaaactct gattgaattt cagaactggg acactctctt gttttgcatt 1020 caggaaggag tgaaaatgtt tttaaagcaa gaaaaattat ttgtggaatt atcaggtgag 1080 gatattaagg aatttagtga agataatggt tttagtttat ttgatgctac tcttcagaag 1140 cgtgtgactt ccgatgagag gagcaatttc caggaagcat gtaataatat tttagattcc 1200 tatgagatgt ttaatttgca gtcaaaagct gtgaaaagaa aaactactgc agaaaacgta 1260 aacacacaga gttctaggga ttcagaagct accagaaaaa atacaaatga tgcatttttg 1320 tacatttatg aatcaggtgg tccaggccat agcaaaatga cagagccatc tttacaaaac 1380 aaagacagct cttgctcaga atcaaagatg ttagaacaag agacaattgt agcatcagaa 1440 gctggagaaa atgagaaaca taaaaaatct ttcctggaac atagctcttt agaaaatccg 1500 tgtggaacca gtttagaaat gtttttaagc ccttttcaga caccatgtca ctttgaggag 1560 agtgggcagg atctagaaat atggaaagaa agtactactg ttaatggcat ggctgccaac 1620 atcttgaaaa ataatagaat tcagaatcaa ccaaagagat ttaaagatgc tactgaagtg 1680 ggatgccagc ctctgccttt tgcaacaaca ttatggggag tacatagtgc tcagacagag 1740 aaagagaaaa aaaaagaatc tagcaattgt ggaagaagaa atgtttttag ttatgggcga 1800 gttaaattat gttccactgg ctttataact catgtagtac aaaatgaaaa aactaaatca 1860 actgaaacag aacattcatt taaaaattat gttagacctg gtcccacacg tgcccaagaa 1920 acatttggaa atagaacacg tcattcagtt gaaactccag acatcaaaga tttagccagc 1980 actttaagta aagaatctgg tcaattgccc aacaaaaaaa attgcagaac gaatataagt 2040 tatgggctag agaatgaacc tacagcaact tatacaatgt tttctgcttt tcaggaaggt 2100 agcaaaaaat cacaaacaga ttgcatatta tctgatacat ccccctcttt cccctggtat 2160 agacacgttt ccaatgatag taggaaaaca gataaattaa ttggtttctc caaaccaatc 2220 gtccgtaaga agctaagctt gagttcacag ctaggatctt tagagaagtt taagaggcaa 2280 tatgggaagg ttgaaaatcc tctggataca gaagtagagg aaagtaatgg agtcactacc 2340 aatctcagtc ttcaagttga acctgacatt ctgctgaagg acaagaaccg cttagagaac 2400 tctgatgttt gtaaaatcac tactatggag catagtgatt cagatagtag ttgtcaacca 2460 gcaagccaca tccttgactc agagaagttt ccattctcca aggatgaaga ttgtttagaa 2520 caacagatgc ctagtttgag agaaagtcct atgaccctga aggagttatc tctctttaat 2580 agaaaacctt tggaccttga gaagtcatct gaatcactag cctctaaatt atccagactg 2640 aagggttccg aaagagaaac tcaaacaatg gggatgatga gtcgttttaa tgaacttcca 2700 aattcagatt ccagtaggaa agacagcaag ttgtgcagtg tgttaacaca agatttttgt 2760 atgttattta acaacaagca tgaaaaaaca gagaatggtg tcatcccaac atcagattct 2820 gccacacagg ataattcctt taataaaaat agtaaaacac attctaacag caatacaaca 2880 gagaactgtg tgatatcaga aactcctttg gtattgccct ataataattc taaagttacc 2940 ggtaaagatt cagatgttct tatcagagcc tcagaacaac agataggaag tcttgactct 3000 cccagtggaa tgttaatgaa tccggtagaa gatgccacag gtgaccaaaa tggaatttgt 3060 tttcagagtg aggaatctaa agcaagagct tgttctgaaa ctgaagagtc aaacacgtgt 3120 tgttcagatt ggcagcggca tttcgatgta gccctgggaa gaatggttta tgtcaacaaa 3180 atgactggac tcagcacatt cattgcccca actgaggaca ttcaggctgc ttgtactaaa 3240 gacctgacaa ctgtggctgt ggatgttgta cttgagaatg ggtctcagta caggtgtcaa 3300 ccttttagaa gcgaccttgt tcttcctttc cttccgagag ctcgagcaga gaggactgtg 3360 atgagacagg ataacagaga tactgtggat gatactgtta gtagcgaatc gcttcagtct 3420 ttgttctcag aatgggacaa tccagtattt gcccgttatc cagaggttgc tgttgatgta 3480 agcagtggcc aggctgagag cttagcagtt aaaattcaca acatcttgta tccctatcgt 3540 ttcaccaaag gaatgattca ttcaatgcag gttctccagc aagtagataa caagtttatt 3600 gcctgtttga tgagcactaa gactgaagag aatggcgagg caggtgggaa cctgctcgtg 3660 ctggtggatc agcacgctgc ccatgagcgt atacgtctgg agcagcttat cattgattcc 3720 tacgagaagc aacaggcaca aggctctggt cggaaaaaat tactgtcttc tactctaatt 3780 cctccgctag agataacagt gacagaggaa caaaggagac tcttatggtg ttaccacaaa 3840 aatctggaag atctgggcct tgaatttgta tttccagaca ctagtgattc tctggtcctt 3900 gtgggaaaag taccactatg ttttgtggaa agagaagcca atgaacttcg gagaggaaga 3960 tctactgtga ccaagagtat tgtggaggaa tttatccgag aacaactgga gctactccag 4020 accaccggag gcatccaagg gacattgcca ctgactgtcc agaaggtgtt ggcatcccaa 4080 gcctgccatg gggccattaa gtttaatgat ggcctgagct tacaggaaag ttgccgcctt 4140 attgaagctc tgtcctcatg ccagctgcca ttccagtgtg ctcacgggag accttctatg 4200 ctgccgttag ctgacataga ccacttggaa caggaaaaac agattaaacc caacctcact 4260 aaacttcgca aaatggccca ggcctggcgt ctctttggaa aagcagagtg tgatacaagg 4320 cagagcctgc agcagtccat gcctccctgt gagccaccat ga 4362 <210> 520 <211> 3004 <212> DNA <213> Homo sapiens <400> 520 agacctaagg aaacgtgtcg tctggaatgg gcttgggggc cacgcctgca catctccgcg 60 agacagaggg ataaagtgaa gatggtgctg ttattgttac ctcgagtgcc acatgcgatc 120 tctgagatat gtacacagtc attcttacta tcgcactcag ccattcttac tacgctaaag 180 aagaaataat tattcgagga tatttgcctg gcccagaaga aacttatgta aatttcatga 240 actattatat ccgttttcct cggagtgaga gaaaactctt tttagatatc atctgagagg 300 tagttaattt ggcaccatgg ggatacaggg attgctacaa tttatcaaag aagcttcaga 360 acccatccat gtgaggaagt ataaagggca ggtagtagct gtggatacat attgctggct 420 tcacaaagga gctattgctt gtgctgaaaa actagccaaa ggtgaaccta ctgataggta 480 tgtaggattt tgtatgaaat ttgtaaatat gttactatct catgggatca agcctattct 540 cgtatttgat ggatgtactt taccttctaa aaaggaagta gagagatcta gaagagaaag 600 acgacaagcc aatcttctta agggaaagca acttcttcgt gaggggaaag tctcggaagc 660 tcgagagtgt ttcacccggt ctatcaatat cacacatgcc atggcccaca aagtaattaa 720 agctgcccgg tctcaggggg tagattgcct cgtggctccc tatgaagctg atgcgcagtt 780 ggcctatctt aacaaagcgg gaattgtgca agccataatt acagaggact cggatctcct 840 agcttttggc tgtaaaaagg taattttaaa gatggaccag tttggaaatg gacttgaaat 900 tgatcaagct cggctaggaa tgtgcagaca gcttggggat gtattcacgg aagagaagtt 960 tcgttacatg tgtattcttt caggttgtga ctacctgtca tcactgcgtg ggattggatt 1020 agcaaaggca tgcaaagtcc taagactagc caataatcca gatatagtaa aggttatcaa 1080 gaaaattgga cattatctca agatgaatat cacggtacca gaggattaca tcaacgggtt 1140 tattcgggcc aacaatacct tcctctatca gctagttttt gatcccatca aaaggaaact 1200 tattcctctg aacgcctatg aagatgatgt tgatcctgaa acactaagct acgctgggca 1260 atatgttgat gattccatag ctcttcaaat agcacttgga aataaagata taaatacttt 1320 tgaacagatc gatgactaca atccagacac tgctatgcct gcccattcaa gaagtcgtag 1380 ttgggatgac aaaacatgtc aaaagtcagc taatgttagc agcatttggc ataggaatta 1440 ctctcccaga ccagagtcgg gtactgtttc agatgcccca caattgaagg aaaatccaag 1500 tactgtggga gtggaacgag tgattagtac taaagggtta aatctcccaa ggaaatcatc 1560 cattgtgaaa agaccaagaa gtgcagagct gtcagaagat gacctgttga gtcagtattc 1620 tctttcattt acgaagaaga ccaagaaaaa tagctctgaa ggcaataaat cattgagctt 1680 ttctgaagtg tttgtgcctg acctggtaaa tggacctact aacaaaaaga gtgtaagcac 1740 tccacctagg acgagaaata aatttgcaac atttttacaa aggaaaaatg aagaaagtgg 1800 tgcagttgtg gttccaggga ccagaagcag gtttttttgc agttcagatt ctactgactg 1860 tgtatcaaac aaagtgagca tccagcctct ggatgaaact gctgtcacag ataaagagaa 1920 caatctgcat gaatcagagt atggagacca agaaggcaag agactggttg acacagatgt 1980 agcacgtaat tcaagtgatg acattccgaa taatcatatt ccaggtgatc atattccaga 2040 caaggcaaca gtgtttacag atgaagagtc ctactctttt gagagcagca aatttacaag 2100 gaccatttca ccacccactt tgggaacact aagaagttgt tttagttggt ctggaggtct 2160 tggagatttt tcaagaacgc cgagcccctc tccaagcaca gcattgcagc agttccgaag 2220 aaagagcgat tcccccacct ctttgcctga gaataatatg tctgatgtgt cgcagttaaa 2280 gagcgaggag tccagtgacg atgagtctca tcccttacga gaaggggcat gttcttcaca 2340 gtcccaggaa agtggagaat tctcactgca gagttcaaat gcatcaaagc tttctcagtg 2400 ctctagtaag gactctgatt cagaggaatc tgattgcaat attaagttac ttgacagtca 2460 aagtgaccag acctccaagc tatgtttatc tcatttctca aaaaaagaca cacctctaag 2520 gaacaaggtt cctgggctat ataagtccag ttctgcagac tctctttcta caaccaagat 2580 caaacctcta ggacctgcca gagccagtgg gctgagcaag aagccggcaa gcatccagaa 2640 gagaaagcat cataatgccg agaacaagcc ggggttacag atcaaactca atgagctctg 2700 gaaaaacttt ggatttaaaa aattctgaaa agcttcctcc ttgtaagaaa cccctgtccc 2760 cagtcagaga taacatccaa ctaactccag aagcggaaga ggatatattt aacaaacctg 2820 aatgtggccg tgttcaaaga gcaatattcc agtaaatgca gactgctgca aagcttttgc 2880 ctgcaagaga atctgatcaa tttgaagtcc ctgtttggga atgaggcact tatcagcatg 2940 aagaattttt tctcattctg tgccatttta aaaatagaat acattttgta tattaacttt 3000 ataa 3004 <210> 521 <211> 2914 <212> DNA <213> Homo sapiens <400> 521 gtgccacatg cgatctctga gatatgtaca cagtcattct tactatcgca ctcagccatt 60 cttactacgc taaagaagaa ataattattc gaggatattt gcctggccca gaagaaactt 120 atgtaaattt catgaactat tatatccgtt ttcctcggag tgagagaaaa ctctttttag 180 atatcatctg agaggtagtt aatttggcac catggggata cagggattgc tacaatttat 240 caaagaagct tcagaaccca tccatgtgag gaagtataaa gggcaggtag tagctgtgga 300 tacatattgc tggcttcaca aaggagctat tgcttgtgct gaaaaactag ccaaaggtga 360 acctactgat aggtatgtag gattttgtat gaaatttgta aatatgttac tatctcatgg 420 gatcaagcct attctcgtat ttgatggatg tactttacct tctaaaaagg aagtagagag 480 atctagaaga gaaagacgac aagccaatct tcttaaggga aagcaacttc ttcgtgaggg 540 gaaagtctcg gaagctcgag agtgtttcac ccggtctatc aatatcacac atgccatggc 600 ccacaaagta attaaagctg cccggtctca gggggtagat tgcctcgtgg ctccctatga 660 agctgatgcg cagttggcct atcttaacaa agcgggaatt gtgcaagcca taattacaga 720 ggactcggat ctcctagctt ttggctgtaa aaaggtaatt ttaaagatgg accagtttgg 780 aaatggactt gaaattgatc aagctcggct aggaatgtgc agacagcttg gggatgtatt 840 cacggaagag aagtttcgtt acatgtgtat tctttcaggt tgtgactacc tgtcatcact 900 gcgtgggatt ggattagcaa aggcatgcaa agtcctaaga ctagccaata atccagatat 960 agtaaaggtt atcaagaaaa ttggacatta tctcaagatg aatatcacgg taccagagga 1020 ttacatcaac gggtttattc gggccaacaa taccttcctc tatcagctag tttttgatcc 1080 catcaaaagg aaacttattc ctctgaacgc ctatgaagat gatgttgatc ctgaaacact 1140 aagctacgct gggcaatatg ttgatgattc catagctctt caaatagcac ttggaaataa 1200 agatataaat acttttgaac agatcgatga ctacaatcca gacactgcta tgcctgccca 1260 ttcaagaagt cgtagttggg atgacaaaac atgtcaaaag tcagctaatg ttagcagcat 1320 ttggcatagg aattactctc ccagaccaga gtcgggtact gtttcagatg ccccacaatt 1380 gaaggaaaat ccaagtactg tgggagtgga acgagtgatt agtactaaag ggttaaatct 1440 cccaaggaaa tcatccattg tgaaaagacc aagaagtgca gagctgtcag aagatgacct 1500 gttgagtcag tattctcttt catttacgaa gaagaccaag aaaaatagct ctgaaggcaa 1560 taaatcattg agcttttctg aagtgtttgt gcctgacctg gtaaatggac ctactaacaa 1620 aaagagtgta agcactccac ctaggacgag aaataaattt gcaacatttt tacaaaggaa 1680 aaatgaagaa agtggtgcag ttgtggttcc agggaccaga agcaggtttt tttgcagttc 1740 agattctact gactgtgtat caaacaaagt gagcatccag cctctggatg aaactgctgt 1800 cacagataaa gagaacaatc tgcatgaatc agagtatgga gaccaagaag gcaagagact 1860 ggttgacaca gatgtagcac gtaattcaag tgatgacatt ccgaataatc atattccagg 1920 tgatcatatt ccagacaagg caacagtgtt tacagatgaa gagtcctact cttttaagag 1980 cagcaaattt acaaggacca tttcaccacc cactttggga acactaagaa gttgttttag 2040 ttggtctgga ggtcttggag atttttcaag aacgccgagc ccctctccaa gcacagcatt 2100 gcagcagttc cgaagaaaga gcgattcccc cacctctttg cctgagaata atatgtctga 2160 tgtgtcgcag ttaaagagcg aggagtccag tgacgatgag tctcatccct tacgagaagg 2220 ggcatgttct tcacagtccc aggaaagtgg agaattctca ctgcagagtt caaatgcatc 2280 aaagctttct cagtgctcta gtaaggactc tgattcagag gaatctgatt gcaatattaa 2340 gttacttgac agtcaaagtg accagacctc caagctatgt ttatctcatt tctcaaaaaa 2400 agacacacct ctaaggaaca aggttcctgg gctatataag tccagttctg cagactctct 2460 ttctacaacc aagatcaaac ctctaggacc tgccagagcc agtgggctga gcaagaagcc 2520 ggcaagcatc cagaagagaa agcatcataa tgccgagaac aagccggggt tacagatcaa 2580 actcaatgag ctctggaaaa actttggatt taaaaaattc tgaaaagctt cctccttgta 2640 agaaacccct gtccccagtc agagataaca tccaactaac tccagaagcg gaagaggata 2700 tatttaacaa acctgaatgt ggccgtgttc aaagagcaat attccagtaa atgcagactg 2760 ctgcaaagct tttgcctgca agagaatctg atcaatttga agtccctgtt tgggaatgag 2820 gcacttatca gcatgaagaa ttttttctca ttctgtgcca ttttaaaaat agaatacatt 2880 ttgtatatta actttaaaaa aaaaaaaaaa aaaa 2914 <210> 522 <211> 2921 <212> DNA <213> Homo sapiens <400> 522 gcacgaggtg ccacatgcga tctctgagat atgtacacag tcattcttac tatcgcactc 60 agccattctt actacgctaa agaagaaata attattcgag gatatttgcc tggcccagaa 120 gaaacttatg taaatttcat gaactattat atccgttttc ctcggagtga gagaaaactc 180 tttttagata tcatctgaga ggtagttaat ttggcaccat ggggatacag ggattgctac 240 aatttatcaa agaagcttca gaacccatcc atgtgaggaa gtataaaggg caggtagtag 300 ctgtggatac atattgctgg cttcacaaag gagctattgc ttgtgctgaa aaactagcca 360 aaggtgaacc tactgatagg tatgtaggat tttgtatgaa atttgtaaat atgttactat 420 ctcatgggat caagcctatt ctcgtatttg atggatgtac tttaccttct aaaaaggaag 480 tagagagatc tagaagagaa agacgacaag ccaatcttct taagggaaag caacttcttc 540 gtgaggggaa agtctcggaa gctcgagagt gtttcacccg gtctatcaat atcacacatg 600 ccatggccca caaagtaatt aaagctgccc ggtctcaggg ggtagattgc ctcgtggctc 660 cctatgaagc tgatgcgcag ttggcctatc ttaacaaagc gggaattgtg caagccataa 720 ttacagagga ctcggatctc ctagcttttg gctgtaaaaa ggtaatttta aagatggacc 780 agtttggaaa tggacttgaa attgatcaag ctcggctagg aatgtgcaga cagcttgggg 840 atgtattcac ggaagagaag tttcgttaca tgtgtattct ttcaggttgt gactacctgt 900 catcactgcg tgggattgga ttagcaaagg catgcaaagt cctaagacta gccaataatc 960 cagatatagt aaaggttatc aagaaaattg gacattatct caagatgaat atcacggtac 1020 cagaggatta catcaacggg tttattcggg ccaacaatac cttcctctat cagctagttt 1080 ttgatcccat caaaaggaaa cttattcctc tgaacgccta tgaagatgat gttgatcctg 1140 aaacactaag ctacgctggg caatatgttg atgattccat agctcttcaa atagcacttg 1200 gaaataaaga tataaatact tttgaacaga tcgatgacta caatccagac actgctatgc 1260 ctgcccattc aagaagtcgt agttgggatg acaaaacatg tcaaaagtca gctaatgtta 1320 gcagcatttg gcataggaat tactctccca gaccagagtc gggtactgtt tcagatgccc 1380 cacaattgaa ggaaaatcca agtactgtgg gagtggaacg agtgattagt actaaagggt 1440 taaatctccc aaggaaatca tccattgtga aaagaccaag aagtgcagag ctgtcagaag 1500 atgacctgtt gagtcagtat tctctttcat ttacgaagaa gaccaagaaa aatagctctg 1560 aaggcaataa atcattgagc ttttctgaag tgtttgtgcc tgacctggta aatggaccta 1620 ctaacaaaaa gagtgtaagc actccaccta ggacgagaaa taaatttgca acatttttac 1680 aaaggaaaaa tgaagaaagt ggtgcagttg tggttccagg gaccagaagc aggttttttt 1740 gcagttcaga ttctactgac tgtgtatcaa acaaagtgag catccagcct ctggatgaaa 1800 ctgctgtcac agataaagag aacaatctgc atgaatcaga gtatggagac caagaaggca 1860 agagactggt tgacacagat gtagcacgta attcaagtga tgacattccg aataatcata 1920 ttccaggtga tcatattcca gacaaggcaa cagtgtttac agatgaagag tcctactctt 1980 ttaagagcag caaatttaca aggaccattt caccacccac tttgggaaca ctaagaagtt 2040 gttttagttg gtctggaggt cttggagatt tttcaagaac gccgagcccc tctccaagca 2100 cagcattgca gcagttccga agaaagagcg attcccccac ctctttgcct gagaataata 2160 tgtctgatgt gtcgcagtta aagagcgagg agtccagtga cgatgagtct catcccttac 2220 gagaaggggc atgttcttca cagtcccagg aaagtggaga attctcactg cagagttcaa 2280 atgcatcaaa gctttctcag tgctctagta aggactctga ttcagaggaa tctgattgca 2340 atattaagtt acttgacagt caaagtgacc agacctccaa gctatgttta tctcatttct 2400 caaaaaaaga cacacctcta aggaacaagg ttcctgggct atataagtcc agttctgcag 2460 actctctttc tacaaccaag atcaaacctc taggacctgc cagagccagt gggctgagca 2520 agaagccggc aagcatccag aagagaaagc atcataatgc cgagaacaag ccggggttac 2580 agatcaaact caatgagctc tggaaaaact ttggatttaa aaaattctga aaagcttcct 2640 ccttgtaaga aacccctgtc cccagtcaga gataacatcc aactaactcc agaagcggaa 2700 gaggatatat ttaacaaacc tgaatgtggc cgtgttcaaa gagcaatatt ccagtaaatg 2760 cagactgctg caaagctttt gcctgcaaga gaatctgatc aatttgaagt ccctgtttgg 2820 gaatgaggca cttatcagca tgaagaattt tttctcattc tgtgccattt taaaaataga 2880 atacattttg tatattaact ttaaaaaaaa aaaaaaaaaa a 2921 <210> 523 <211> 3006 <212> DNA <213> Homo sapiens <400> 523 agacctaagg aaacgtgtcg tctggaatgg gcttgggggc cacgcctgca catctccgcg 60 agacagaggg ataaagtgaa gatggtgctg ttattgttac ctcgagtgcc acatgcgatc 120 tctgagatat gtacacagtc attcttacta tcgcactcag ccattcttac tacgctaaag 180 aagaaataat tattcgagga tatttgcctg gcccagaaga aacttatgta aatttcatga 240 actattatat ccgttttcct cggagtgaga gaaaactctt tttagatatc atctgagagg 300 tagttaattt ggcaccatgg ggatacaggg attgctacaa tttatcaaag aagcttcaga 360 acccatccat gtgaggaagt ataaagggca ggtagtagct gtggatacat attgctggct 420 tcacaaagga gctattgctt gtgctgaaaa actagccaaa ggtgaaccta ctgataggta 480 tgtaggattt tgtatgaaat ttgtaaatat gttactatct catgggatca agcctattct 540 cgtatttgat ggatgtactt taccttctaa aaaggaagta gagagatcta gaagagaaag 600 acgacaagcc aatcttctta agggaaagca acttcttcgt gaggggaaag tctcggaagc 660 tcgagagtgt ttcacccggt ctatcaatat cacacatgcc atggcccaca aagtaattaa 720 agctgcccgg tctcaggggg tagattgcct cgtggctccc tatgaagctg atgcgcagtt 780 ggcctatctt aacaaagcgg gaattgtgca agccataatt acagaggact cggatctcct 840 agcttttggc tgtaaaaagg taattttaaa gatggaccag tttggaaatg gacttgaaat 900 tgatcaagct cggctaggaa tgtgcagaca gcttggggat gtattcacgg aagagaagtt 960 tcgttacatg tgtattcttt caggttgtga ctacctgtca tcactgcgtg ggattggatt 1020 agcaaaggca tgcaaagtcc taagactagc caataatcca gatatagtaa aggttatcaa 1080 gaaaattgga cattatctca agatgaatat cacggtacca gaggattaca tcaacgggtt 1140 tattcgggcc aacaatacct tcctctatca gctagttttt gatcccatca aaaggaaact 1200 tattcctctg aacgcctatg aagatgatgt tgatcctgaa acactaagct acgctgggca 1260 atatgttgat gattccatag ctcttcaaat agcacttgga aataaagata taaatacttt 1320 tgaacagatc gatgactaca atccagacac tgctatgcct gcccattcaa gaagtcgtag 1380 ttgggatgac aaaacatgtc aaaagtcagc taatgttagc agcatttggc ataggaatta 1440 ctctcccaga ccagagtcgg gtactgtttc agatgcccca caattgaagg aaaatccaag 1500 tactgtggga gtggaacgag tgattagtac taaagggtta aatctcccaa ggaaatcatc 1560 cattgtgaaa agaccaagaa gtgcagagct gtcagaagat gacctgttga gtcagtattc 1620 tctttcattt acgaagaaga ccaagaaaaa tagctctgaa ggcaataaat cattgagctt 1680 ttctgaagtg tttgtgcctg acctggtaaa tggacctact aacaaaaaga gtgtaagcac 1740 tccacctagg acgagaaata aatttgcaac atttttacaa aggaaaaatg aagaaagtgg 1800 tgcagttgtg gttccaggga ccagaagcag gtttttttgc agttcagatt ctactgactg 1860 tgtatcaaac aaagtgagca tccagcctct ggatgaaact gctgtcacag ataaagagaa 1920 caatctgcat gaatcagagt atggagacca agaaggcaag agactggttg acacagatgt 1980 agcacgtaat tcaagtgatg acattccgaa taatcatatt ccaggtgatc atattccaga 2040 caaggcaaca gtgtttacag atgaagagtc ctactctttt gagagcagca aatttacaag 2100 gaccatttca ccacccactt tgggaacact aagaagttgt tttagttggt ctggaggtct 2160 tggagatttt tcaagaacgc cgagcccctc tccaagcaca gcattgcagc agttccgaag 2220 aaagagcgat tcccccacct ctttgcctga gaataatatg tctgatgtgt cgcagttaaa 2280 gagcgaggag tccagtgacg atgagtctca tcccttacga gaaggggcat gttcttcaca 2340 gtcccaggaa agtggagaat tctcactgca gagttcaaat gcatcaaagc tttctcagtg 2400 ctctagtaag gactctgatt cagaggaatc tgattgcaat attaagttac ttgacagtca 2460 aagtgaccag acctccaagc tatgtttatc tcatttctca aaaaaagaca cacctctaag 2520 gaacaaggtt cctgggctat ataagtccag ttctgcagac tctctttcta caaccaagat 2580 caaacctcta ggacctgcca gagccagtgg gctgagcaag aagccggcaa gcatccagaa 2640 gagaaagcat cataatgccg agaacaagcc ggggttacag atcaaactca atgagctctg 2700 gaaaaacttt ggatttaaaa aagattctga aaagcttcct ccttgtaaga aacccctgtc 2760 cccagtcaga gataacatcc aactaactcc agaagcggaa gaggatatat ttaacaaacc 2820 tgaatgtggc cgtgttcaaa gagcaatatt ccagtaaatg cagactgctg caaagctttt 2880 gcctgcaaga gaatctgatc aatttgaagt ccctgtttgg gaatgaggca cttatcagca 2940 tgaagaattt tttctcattc tgtgccattt taaaaataga atacattttg tatattaact 3000 ttataa 3006 <210> 524 <211> 3238 <212> DNA <213> Homo sapiens <400> 524 gcgttgccgg ccgtgggtgc tctggccaca gtgagttagg ggcgtcggag cgggtttctc 60 caaccgcaat cggctccgct caaggggagg aggagagtcc cttctcggaa ggcctaagga 120 aacgtgtcgt ctggaatggg cttgggggcc acgcctgcac atctccgcga gacagaggga 180 taaagtgaag atggtgctgt tattgttacc tcgagtgcca catgcgacct ctgagatatg 240 tacacagtca ttcttactat cgcactcagc cattcttact acgctaaaga agaaataatt 300 attcgaggat atttgcctgg cccagaagaa acttatgtaa atttcatgaa ctattatatc 360 cgttttcctc ggagtgagag aaaactcttt ttagatatca tctgagagaa ctagtgaatc 420 ccagtcactg agtggagttg agagtctaag aacctctgaa atttgagaac tgctggacca 480 gagcctttag agctctgata aggtgtcaac agggtagtta atttggcacc atggggatac 540 agggattgct acaatttatc aaagaagctt cagaacccat ccatgtgagg aagtataaag 600 ggcaggtagt agctgtggat acatattgct ggcttcacaa aggagctatt gcttgtgctg 660 aaaaactagc caaaggtgaa cctactgata ggtatgtagg attttgtatg aaatttgtaa 720 atatgttact atctcatggg atcaagccta ttctcgtatt tgatggatgt actttacctt 780 ctaaaaagga agtagagaga tctagaagag aaagacgaca agccaatctt cttaagggaa 840 agcaacttct tcgtgagggg aaagtctcgg aagctcgaga gtgtttcacc cggtctatca 900 atatcacaca tgccatggcc cacaaagtaa ttaaagctgc ccggtctcag ggggtagatt 960 gcctcgtggc tccctatgaa gctgatgcgc agttggccta tcttaacaaa gcgggaattg 1020 tgcaagccat aattacagag gactcggatc tcctagcttt tggctgtaaa aaggtaattt 1080 taaagatgga ccagtttgga aatggacttg aaattgatca agctcggcta ggaatgtgca 1140 gacagcttgg ggatgtattc acggaagaga agtttcgtta catgtgtatt ctttcaggtt 1200 gtgactacct gtcatcactg cgtgggattg gattagcaaa ggcatgcaaa gtcctaagac 1260 tagccaataa tccagatata gtaaaggtta tcaagaaaat tggacattat ctcaagatga 1320 atatcacggt accagaggat tacatcaacg ggtttattcg ggccaacaat accttcctct 1380 atcagctagt ttttgatccc atcaaaagga aacttattcc tctgaacgcc tatgaagatg 1440 atgttgatcc tgaaacacta agctacgctg ggcaatatgt tgatgattcc atagctcttc 1500 aaatagcact tggaaataaa gatataaata cttttgaaca gatcgatgac tacaatccag 1560 acactgctat gcctgcccat tcaagaagtc atagttggga tgacaaaaca tgtcaaaagt 1620 cagctaatgt tagcagcatt tggcatagga attactctcc cagaccagag tcgggtactg 1680 tttcagatgc cccacaattg aaggaaaatc caagtactgt gggagtggaa cgagtgatta 1740 gtactaaagg gttaaatctc ccaaggaaat catccattgt gaaaagacca agaagtgcag 1800 agctgtcaga agatgacctg ttgagtcagt attctctttc atttacgaag aagaccaaga 1860 aaaatagctc tgaaggcaat aaatcattga gcttttctga agtgtttgtg cctgacctgg 1920 taaatggacc tactaacaaa aagagtgtaa gcactccacc taggacgaga aataaatttg 1980 caacattttt acaaaggaaa aatgaagaaa gtggtgcagt tgtggttcca gggaccagaa 2040 gcaggttttt ttgcagttca gattctactg actgtgtatc aaacaaagtg agcatccagc 2100 ctctggatga aactgctgtc acagataaag agaacaatct gcatgaatca gagtatggag 2160 accaagaagg caagagactg gttgacacag atgtagcacg taattcaagt gatgacattc 2220 cgaataatca tattccaggt gatcatattc cagacaaggc aacagtgttt acagatgaag 2280 agtcctactc ttttgagagc agcaaattta caaggaccat ttcaccaccc actttgggaa 2340 cactaagaag ttgttttagt tggtctggag gtcttggaga tttttcaaga acgccgagcc 2400 cctctccaag cacagcattg cagcagttcc gaagaaagag cgattccccc acctctttgc 2460 ctgagaataa tatgtctgat gtgtcgcagt taaagagcga ggagtccagt gacgatgagt 2520 ctcatccctt acgagaaggg gcatgttctt cacagtccca ggaaagtgga gaattctcac 2580 tgcagagttc aaatgcatca aagctttctc agtgctctag taaggactct gattcagagg 2640 aatctgattg caatattaag ttacttgaca gtcaaagtga ccagacctcc aagctatgtt 2700 tatctcattt ctcaaaaaaa gacacacctc taaggaacaa ggttcctggg ctatataagt 2760 ccagttctgc agactctctt tctacaacca agatcaaacc tctaggacct gccagagcca 2820 gtgggctgag caagaagccg gcaagcatcc agaagagaaa gcatcataat gccgagaaca 2880 agccggggtt acagatcaaa ctcaatgagc tctggaaaaa ctttggattt aaaaaagatt 2940 ctgaaaagct tcctccttgt aagaaacccc tgtccccagt cagagataac atccaactaa 3000 ctccagaagc ggaagaggat atatttaaca aacctgaatg tggccgtgtt caaagagcaa 3060 tattccagta aatgcagact gctgcaaagc ttttgcctgc aagagaatct gatcaatttg 3120 aagtccctgt ttgggaatga ggcacttatc agcatgaaga attttttctc attctgtgcc 3180 attttaaaaa tagaatacat tttgtatatt gactttaaaa aaaaaaaaaa aaaaaaaa 3238 <210> 525 <211> 3239 <212> DNA <213> Homo sapiens <400> 525 ggcgttgccg gccgtgggtg ctctggccac agtgagttag gggcgtcgga gcgggtttct 60 ccaaccgcaa tcggctccgc tcaaggggag gaggagagtc ccttctcgga aggcctaagg 120 aaacgtgtcg tctggaatgg gcttgggggc cacgcctgca catctccgcg agacagaggg 180 ataaagtgaa gatggtgctg ttattgttac ctcgagtgcc acatgcgacc tctgagatat 240 gtacacagtc attcttacta tcgcactcag ccattcttac tacgctaaag aagaaataat 300 tattcgagga tatttgcctg gcccagaaga aacttatgta aatttcatga actattatat 360 ccgttttcct cggagtgaga gaaaactctt tttagatatc atctgagaga actagtgaat 420 cccagtcact gagtggagtt gagagtctaa gaacctctga aatttgagaa ctgctggacc 480 agagccttta gagctctgat aaggtgtcaa cagggtagtt aatttggcac catggggata 540 cagggattgc tacaatttat caaagaagct tcagaaccca tccatgtgag gaagtataaa 600 gggcaggtag tagctgtgga tacatattgc tggcttcaca aaggagctat tgcttgtgct 660 gaaaaactag ccaaaggtga acctactgat aggtatgtag gattttgtat gaaatttgta 720 aatatgttac tatctcatgg gatcaagcct attctcgtat ttgatggatg tactttacct 780 tctaaaaagg aagtagagag atctagaaga gaaagacgac aagccaatct tcttaaggga 840 aagcaacttc ttcgtgaggg gaaagtctcg gaagctcgag agtgtttcac ccggtctatc 900 aatatcacac atgccatggc ccacaaagta attaaagctg cccggtctca gggggtagat 960 tgcctcgtgg ctccctatga agctgatgcg cagttggcct atcttaacaa agcgggaatt 1020 gtgcaagcca taattacaga ggactcggat ctcctagctt ttggctgtaa aaaggtaatt 1080 ttaaagatgg accagtttgg aaatggactt gaaattgatc aagctcggct aggaatgtgc 1140 agacagcttg gggatgtatt cacggaagag aagtttcgtt acatgtgtat tctttcaggt 1200 tgtgactacc tgtcatcact gcgtgggatt ggattagcaa aggcatgcaa agtcctaaga 1260 ctagccaata atccagatat agtaaaggtt atcaagaaaa ttggacatta tctcaagatg 1320 aatatcacgg taccagagga ttacatcaac gggtttattc gggccaacaa taccttcctc 1380 tatcagctag tttttgatcc catcaaaagg aaacttattc ctctgaacgc ctatgaagat 1440 gatgttgatc ctgaaacact aagctacgct gggcaatatg ttgatgattc catagctctt 1500 caaatagcac ttggaaataa agatataaat acttttgaac agatcgatga ctacaatcca 1560 gacactgcta tgcctgccca ttcaagaagt catagttggg atgacaaaac atgtcaaaag 1620 tcagctaatg ttagcagcat ttggcatagg aattactctc ccagaccaga gtcgggtact 1680 gtttcagatg ccccacaatt gaaggaaaat ccaagtactg tgggagtgga acgagtgatt 1740 agtactaaag ggttaaatct cccaaggaaa tcatccattg tgaaaagacc aagaagtgca 1800 gagctgtcag aagatgacct gttgagtcag tattctcttt catttacgaa gaagaccaag 1860 aaaaatagct ctgaaggcaa taaatcattg agcttttctg aagtgtttgt gcctgacctg 1920 gtaaatggac ctactaacaa aaagagtgta agcactccac ctaggacgag aaataaattt 1980 gcaacatttt tacaaaggaa aaatgaagaa agtggtgcag ttgtggttcc agggaccaga 2040 agcaggtttt tttgcagttc agattctact gactgtgtat caaacaaagt gagcatccag 2100 cctctggatg aaactgctgt cacagataaa gagaacaatc tgcatgaatc agagtatgga 2160 gaccaagaag gcaagagact ggttgacaca gatgtagcac gtaattcaag tgatgacatt 2220 ccgaataatc atattccagg tgatcatatt ccagacaagg caacagtgtt tacagatgaa 2280 gagtcctact cttttgagag cagcaaattt acaaggacca tttcaccacc cactttggga 2340 acactaagaa gttgttttag ttggtctgga ggtcttggag atttttcaag aacgccgagc 2400 ccctctccaa gcacagcatt gcagcagttc cgaagaaaga gcgattcccc cacctctttg 2460 cctgagaata atatgtctga tgtgtcgcag ttaaagagcg aggagtccag tgacgatgag 2520 tctcatccct tacgagaagg ggcatgttct tcacagtccc aggaaagtgg agaattctca 2580 ctgcagagtt caaatgcatc aaagctttct cagtgctcta gtaaggactc tgattcagag 2640 gaatctgatt gcaatattaa gttacttgac agtcaaagtg accagacctc caagctatgt 2700 ttatctcatt tctcaaaaaa agacacacct ctaaggaaca aggttcctgg gctatataag 2760 tccagttctg cagactctct ttctacaacc aagatcaaac ctctaggacc tgccagagcc 2820 agtgggctga gcaagaagcc ggcaagcatc cagaagagaa agcatcataa tgccgagaac 2880 aagccggggt tacagatcaa actcaatgag ctctggaaaa actttggatt taaaaaagat 2940 tctgaaaagc ttcctccttg taagaaaccc ctgtccccag tcagagataa catccaacta 3000 actccagaag cggaagagga tatatttaac aaacctgaat gtggccgtgt tcaaagagca 3060 atattccagt aaatgcagac tgctgcaaag cttttgcctg caagagaatc tgatcaattt 3120 gaagtccctg tttgggaatg aggcacttat cagcatgaag aattttttct cattctgtgc 3180 cattttaaaa atagaataca ttttgtatat tgactttaaa aaaaaaaaaa aaaaaaaaa 3239 <210> 526 <211> 2913 <212> DNA <213> Homo sapiens <400> 526 tgcacatgcg atctctgaga tatgtacaca gtcattctta ctatcgcact cagccattct 60 tactacgcta aagaagaaat aattattcga ggatatttgc ctggcccaga agaaacttat 120 gtaaatttca tgaactatta tatccgtttt cctcggagtg agagaaaact ctttttagat 180 atcatctgag aggtagttaa tttggcacca tggggataca gggattgcta caatttatca 240 aagaagcttc agaacccatc catgtgagga agtataaagg gcaggtagta gctgtggata 300 catattgctg gcttcacaaa ggagctattg cttgtgctga aaaactagcc aaaggtgaac 360 ctactgatag gtatgtagga ttttgtatga aatttgtaaa tatgttacta tctcatggga 420 tcaagcctat tctcgtattt gatggatgta ctttaccttc taaaaaggaa gtagagagat 480 ctagaagaga aagacgacaa gccaatcttc ttaagggaaa gcaacttctt cgtgagggga 540 aagtctcgga agctcgagag tgtttcaccc ggtctatcaa tatcacacat gccatggccc 600 acaaagtaat taaagctgcc cggtctcagg gggtagattg cctcgtggct ccctatgaag 660 ctgatgcgca gttggcctat cttaacaaag cgggaattgt gcaagccata attacagagg 720 actcggatct cctagctttt ggctgtaaaa aggtaatttt aaagatggac cagtttggaa 780 atggacttga aattgatcaa gctcggctag gaatgtgcag acagcttggg gatgtattca 840 cggaagagaa gtttcgttac atgtgtattc tttcaggttg tgactacctg tcatcactgc 900 gtgggattgg attagcaaag gcatgcaaag tcctaagact agccaataat ccagatatag 960 taaaggttat caagaaaatt ggacattatc tcaagatgaa tatcacggta ccagaggatt 1020 acatcaacgg gtttattcgg gccaacaata ccttcctcta tcagctagtt tttgatccca 1080 tcaaaaggaa acttattcct ctgaacgcct atgaagatga tgttgatcct gaaacactaa 1140 gctacgctgg gcaatatgtt gatgattcca tagctcttca aatagcactt ggaaataaag 1200 atataaatac ttttgaacag atcgatgact acaatccaga cactgctatg cctgcccatt 1260 caagaagtcg tagttgggat gacaaaacat gtcaaaagtc agctaatgtt agcagcattt 1320 ggcataggaa ttactctccc agaccagagt cgggtactgt ttcagatgcc ccacaattga 1380 aggaaaatcc aagtactgtg ggagtggaac gagtgattag tactaaaggg ttaaatctcc 1440 caaggaaatc atccattgtg aaaagaccaa gaagtgcaga gctgtcagaa gatgacctgt 1500 tgagtcagta ttctctttca tttacgaaga agaccaagaa aaatagctct gaaggcaata 1560 aatcattgag cttttctgaa gtgtttgtgc ctgacctggt aaatggacct actaacaaaa 1620 agagtgtaag cactccacct aggacgagaa ataaatttgc aacattttta caaaggaaaa 1680 atgaagaaag tggtgcagtt gtggttccag ggaccagaag caggtttttt tgcagttcag 1740 attctactga ctgtgtatca aacaaagtga gcatccagcc tctggatgaa actgctgtca 1800 cagataaaga gaacaatctg catgaatcag agtatggaga ccaagaaggc aagagactgg 1860 ttgacacaga tgtagcacgt aattcaagtg atgacattcc gaataatcat attccaggtg 1920 atcatattcc agacaaggca acagtgttta cagatgaaga gtcctactct tttaagagca 1980 gcaaatttac aaggaccatt tcaccaccca ctttgggaac actaagaagt tgttttagtt 2040 ggtctggagg tcttggagat ttttcaagaa cgccgagccc ctctccaagc acagcattgc 2100 agcagttccg aagaaagagc gattccccca cctctttgcc tgagaataat atgtctgatg 2160 tgtcgcagtt aaagagcgag gagtccagtg acgatgagtc tcatccctta cgagaagggg 2220 catgttcttc acagtcccag gaaagtggag aattctcact gcagagttca aatgcatcaa 2280 agctttctca gtgctctagt aaggactctg attcagagga atctgattgc aatattaagt 2340 tacttgacag tcaaagtgac cagacctcca agctatgttt atctcatttc tcaaaaaaag 2400 acacacctct aaggaacaag gttcctgggc tatataagtc cagttctgca gactctcttt 2460 ctacaaccaa gatcaaacct ctaggacctg ccagagccag tgggctgagc aagaagccgg 2520 caagcatcca gaagagaaag catcataatg ccgagaacaa gccggggtta cagatcaaac 2580 tcaatggagc tctggaaaaa ctttggattt aaaaaattct gaaaagcttc ctccttgtaa 2640 gaaacccctg tccccagtca gagataacat ccaactaact ccagaagcgg aagaggatat 2700 atttaacaaa cctgaatgtg gccgtgttca aagagcaata ttccagtaaa tgcagactgc 2760 tgcaaagctt ttgcctgcaa gagaatctga tcaatttgaa gtccctgttt gggaatgagg 2820 cacttatcag catgaagaat tttttctcat tctgtgccat tttaaaaata gaatacattt 2880 tgtatattaa ctttaaaaaa aaaaaaaaaa aaa 2913 <210> 527 <211> 2912 <212> DNA <213> Homo sapiens <400> 527 tgcacatgcg atctctgaga tatgtacaca gtcattctta ctatcgcact cagccattct 60 tactacgcta aagaagaaat aattattcga ggatatttgc ctggcccaga agaaacttat 120 gtaaatttca tgaactatta tatccgtttt cctcggagtg agagaaaact ctttttagat 180 atcatctgag aggtagttaa tttggcacca tggggataca gggattgcta caatttatca 240 aagaagcttc agaacccatc catgtgagga agtataaagg gcaggtagta gctgtggata 300 catattgctg gcttcacaaa ggagctattg cttgtgctga aaaactagcc aaaggtgaac 360 ctactgatag gtatgtagga ttttgtatga aatttgtaaa tatgttacta tctcatggga 420 tcaagcctat tctcgtattt gatggatgta ctttaccttc taaaaaggaa gtagagagat 480 ctagaagaga aagacgacaa gccaatcttc ttaagggaaa gcaacttctt cgtgagggga 540 aagtctcgga agctcgagag tgtttcaccc ggtctatcaa tatcacacat gccatggccc 600 acaaagtaat taaagctgcc cggtctcagg gggtagattg cctcgtggct ccctatgaag 660 ctgatgcgca gttggcctat cttaacaaag cgggaattgt gcaagccata attacagagg 720 actcggatct cctagctttt ggctgtaaaa aggtaatttt aaagatggac cagtttggaa 780 atggacttga aattgatcaa gctcggctag gaatgtgcag acagcttggg gatgtattca 840 cggaagagaa gtttcgttac atgtgtattc tttcaggttg tgactacctg tcatcactgc 900 gtgggattgg attagcaaag gcatgcaaag tcctaagact agccaataat ccagatatag 960 taaaggttat caagaaaatt ggacattatc tcaagatgaa tatcacggta ccagaggatt 1020 acatcaacgg gtttattcgg gccaacaata ccttcctcta tcagctagtt tttgatccca 1080 tcaaaaggaa acttattcct ctgaacgcct atgaagatga tgttgatcct gaaacactaa 1140 gctacgctgg gcaatatgtt gatgattcca tagctcttca aatagcactt ggaaataaag 1200 atataaatac ttttgaacag atcgatgact acaatccaga cactgctatg cctgcccatt 1260 caagaagtcg tagttgggat gacaaaacat gtcaaaagtc agctaatgtt agcagcattt 1320 ggcataggaa ttactctccc agaccagagt cgggtactgt ttcagatgcc ccacaattga 1380 aggaaaatcc aagtactgtg ggagtggaac gagtgattag tactaaaggg ttaaatctcc 1440 caaggaaatc atccattgtg aaaagaccaa gaagtgcaga gctgtcagaa gatgacctgt 1500 tgagtcagta ttctctttca tttacgaaga agaccaagaa aaatagctct gaaggcaata 1560 aatcattgag cttttctgaa gtgtttgtgc ctgacctggt aaatggacct actaacaaaa 1620 agagtgtaag cactccacct aggacgagaa ataaatttgc aacattttta caaaggaaaa 1680 atgaagaaag tggtgcagtt gtggttccag ggaccagaag caggtttttt tgcagttcag 1740 attctactga ctgtgtatca aacaaagtga gcatccagcc tctggatgaa actgctgtca 1800 cagataaaga gaacaatctg catgaatcag agtatggaga ccaagaaggc aagagactgg 1860 ttgacacaga tgtagcacgt aattcaagtg atgacattcc gaataatcat attccaggtg 1920 atcatattcc agacaaggca acagtgttta cagatgaaga gtcctactct tttaagagca 1980 gcaaatttac aaggaccatt tcaccaccca ctttgggaac actaagaagt tgttttagtt 2040 ggtctggagg tcttggagat ttttcaagaa cgccgagccc ctctccaagc acagcattgc 2100 agcagttccg aagaaagagc gattccccca cctctttgcc tgagaataat atgtctgatg 2160 tgtcgcagtt aaagagcgag gagtccagtg acgatgagtc tcatccctta cgagaagggg 2220 catgttcttc acagtcccag gaaagtggag aattctcact gcagagttca aatgcatcaa 2280 agctttctca gtgctctagt aaggactctg attcagagga atctgattgc aatattaagt 2340 tacttgacag tcaaagtgac cagacctcca agctatgttt atctcatttc tcaaaaaaag 2400 acacacctct aaggaacaag gttcctgggc tatataagtc cagttctgca gactctcttt 2460 ctacaaccaa gatcaaactt ctaggacctg ccagagccag tgggctgagc aagaagccgg 2520 caagcatcca gaagagaaag catcataatg ccgagaacaa gccggggtta cagatcaaac 2580 tcaatgagct ctggaaaaac tttggattta aaaaagattc tgaaaagctt cctccttgta 2640 agaaacccct gtccccagtc agagataaca tccaactaac tccagaagcg gaagaggata 2700 tatttaacaa acctgaatgt ggccgtgttc aaagagcaat attccagtaa atgcagactg 2760 ctgcaaagct tttgcctgca agagaatctg atcaatttga agtccctgtt tgggaatgag 2820 gcacttatca gcatgaagaa ttttttctca ttctgtgcca ttttaaaaat agaatacatt 2880 tgtatattaa ctttaaaaaa aaaaaaaaaa aa 2912 <210> 528 <211> 2220 <212> DNA <213> Homo sapiens <400> 528 gcctagcttt tggctgtaaa aaggtaattt taaagatgga ccagtttgga aatggacttg 60 aaattgatca agctcggcta ggaatgtgca gacagcttgg ggatgtattc acggaagaga 120 agtttcgtta catgtgtatt ctttcaggtt gtgactacct gtcatcactg cgtgggattg 180 gattagcaaa ggcatgcaaa gtcctaagac tagccaataa tccagatata gtaaaggtta 240 tcaagaaaat tggacattat ctcaagatga atatcacggt accagaggat tacatcaacg 300 ggtttattcg ggccaacaat accttcctct atcagctagt ttttgatccc atcaaaagga 360 aacttattcc tctgaacgcc tatgaagatg atgttgatcc tgaaacacta agctacgctg 420 ggcaatatgt tgatgattcc atagctcttc aaatagcact tggaaataaa gatataaata 480 cttttgaaca gatcgatgac tacaatccag acactgctat gcctgcccat tcaagaagtc 540 atagttggga tgacaaaaca tgtcaaaagt cagctaatgt tagcagcatt tggcatagga 600 attactctcc cagaccagag tcgggtactg tttcagatgc cccacaattg aaggaaaatc 660 caagtactgt gggagtggaa cgagtgatta gtactaaagg gttaaatctc ccaaggaaat 720 catccattgt gaaaagacca agaagtgcag agctgtcaga agatgacctg ttgagtcagt 780 attctctttc atttacgaag aagaccaaga aaaatagctc tgaaggcaat aaatcattga 840 gcttttctga agtgtttgtg cctgacctgg taaatggacc tactaacaaa aagagtgtaa 900 gcactccacc taggacgaga aataaatttg caacattttt acaaaggaaa aatgaagaaa 960 gtggtgcagt tgtggttcca gggaccagaa gcaggttttt ttgcagttca gattctactg 1020 actgtgtatc aaacaaagtg agcatccagc ctctggatga aactgctgtc acagataaag 1080 agaacaatct gcatgaatca gagtatggag accaagaagg caagagactg gttgacacag 1140 atgtagcacg taattcaagt gatgacattc cgaataatca tattccaggt gatcatattc 1200 cagacaaggc aacagtgttt acagatgaag agtcctactc ttttaagagc agcaaattta 1260 caaggaccat ttcaccaccc actttgggaa cactaagaag ttgttttagt tggtctggag 1320 gtcttggaga tttttcaaga acgccgagcc cctctccaag cacagcattg cagcagttcc 1380 gaagaaagag cgattccccc acctctttgc ctgagaataa tatgtctgat gtgtcgcagt 1440 taaagagcga ggagtccagt gacgatgagt ctcatccctt acgagaaggg gcatgttctt 1500 cacagtccca ggaaagtgga gaattctcac tgcagagttc aaatgcatca aagctttctc 1560 agtgctctag taaggactct gattcagagg aatctgattg caatattaag ttacttgaca 1620 gtcaaagtga ccagacctcc aagctatgtt tatctcattt ctcaaaaaaa gacacacctc 1680 taaggaacaa ggttcctggg ctatataagt ccagttctgc agactctctt tctacaacca 1740 agatcaaacc tctaggacct gccagagcca gtgggctgag caagaagccg gcaagcatcc 1800 agaagagaaa gcatcataat gccgagaaca agccggggtt acagatcaaa ctcaatgagc 1860 tctggaaaaa ctttggattt aaaaaagatt ctgaaaagct tcctccttgt aagaaacccc 1920 tgtccccagt cagagataac atccaactaa ctccagaagc ggaagaggat atatttaaca 1980 aacctgaatg tggccgtgtt caaagagcaa tattccagta aatgcagact gctgcaaagc 2040 ttttgcctgc aagagaatct gatcaatttg aagtccctgt ttgggaatga ggcacttatc 2100 agcatgaaga attttttctc attctgtgcc attttaaaaa tagaatacat tttgtatatt 2160 gactttaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2220 <210> 529 <211> 2484 <212> DNA <213> Homo sapiens <400> 529 gctgggggtg gagccggagg aggaaggcgg cggcgacgac gaggaagacg ccgaggcctg 60 ggccatggaa ctggcggacg tgggggcggc agccagctcg cagggagttc atgatcaagt 120 gttgcccaca ccaaatgctt catccagagt catagtacat gtggatctgg attgctttta 180 tgcacaagta gaaatgatct caaatccaga gctaaaagac aaacctttag gggttcaaca 240 gaaatatttg gtggttacct gcaactatga agctaggaaa cttggagtta agaaacttat 300 gaatgtcaga gatgcaaaag aaaagtgtcc acagttggta ttagttaatg gagaagacct 360 gacccgctac agagaaatgt cttataaggt tacagaatta ctggaagaat ttagtccagt 420 tgttgagaga cttggatttg atgaaaattt tgtggatcta acagaaatgg ttgagaagag 480 actacagcag ctgcaaagtg atgaactttc tgcggtgact gtgtcgggtc atgtatacaa 540 taatcagtct ataaacctgc ttgacgtctt gcacatcaga ctacttgttg gatctcagat 600 tgcagcagag atgcgggaag ccatgtataa tcagttgggg ctcactggct gtgctggagt 660 ggcttctaat aaactgttgg caaaattagt ttctggtgtc tttaaaccaa atcaacaaac 720 agtcttatta cctgaaagtt gtcaacatct tattcatagt ttgaatcaca taaaggaaat 780 acctggtatt ggctataaaa ctgccaaatg tcttgaagca ctgggtatca atagtgtgcg 840 tgatctccaa accttttcac ccaaaatttt agaaaaagaa ttaggaattt cagttgctca 900 gcgtatccaa aagctcagtt ttggagagga taactcccct gtgatactct caggaccacc 960 tcagtccttt agtgaagaag attcatttaa aaaatgttca tctgaagttg aagctaaaaa 1020 taagattgaa gaactacttg ctagtctttt aaacagagta tgccaagatg gaaggaagcc 1080 tcatacagtg agattaataa tccgtcggta ttcctctgag aagcactatg gtcgtgagag 1140 tcgtcagtgc cctattcctt cacatgtaat tcagaaatta gggacaggaa attatgatgt 1200 gatgacccca atggttgata tacttatgaa actttttcga aatatggtga atgtgaagat 1260 gccatttcac cttacccttc taagtgtgtg cttctgcaac cttaaagcac taaatactgc 1320 taagaaaggg cttattgatt attatttaat gccatcatta tcaactactt cacgctctgg 1380 caagcacagt tttaaaatga aagacactca tatggaagat tttcccaaag acaaagaaac 1440 aaaccgggat ttcctaccaa gtggaagaat tgaaagtaca agaactaggg agtctccact 1500 agataccaca aatttttcta aagaaaaaga cattaatgaa ttcccactct gttcacttcc 1560 tgaaggtgtt gaccaagaag tcttcaagca gcttccagta gatattcaag aagaaatcct 1620 ttctggaaaa tctagggaaa aatttcaagg gaaaggaagt gtgagttgtc cattacatgc 1680 ctctagagga gtattatctt tcttttctaa aaaacaaatg caagatattc ccataaatcc 1740 tagagatcat ttatccagta gcaaacaggt atcctctgta tctccttgtg aaccgggaac 1800 atcaggcttt aatagcagta gttcttctta catgtctagc caaaaggatt attcatatta 1860 tttagataat agattaaaag atgaacgaat aagtcaagga cctaaagaac ctcaaggatt 1920 ccactttaca aattcaaacc ctgctgtgtc tgcttttcat tcatttccaa acttgcagag 1980 tgagcaactt ttctccagaa accacactac agatagccat aagcaaacag tagcaacaga 2040 ctctcatgaa ggacttacag aaaatagaga gccagattct gttgatgaga aaattacttt 2100 cccttctgac attgatcctc aagttttcta tgaactacca gaagcagtac aaaaggaact 2160 gctggcagag tggaagagaa caggatcaga tttccacatt ggacataaat aagcatattc 2220 agcaaaaagg tctgaaaagc aagggaatac cattattttc ggattagcgg tttattaagc 2280 tcttctatat taaacactaa tagatattca ataacggagt aaactgttcc agataaagca 2340 agaatagttg caagaagtaa attctggcac aaagcgtaaa aatataacag aagaaataat 2400 gtaaaatact atcttttatg tctaaagcca ttttatatta cttttcaata aaaagaatat 2460 catggtcaaa aaaaaaaaaa aaaa 2484 <210> 530 <211> 2484 <212> DNA <213> Homo sapiens <400> 530 gctgggggtg gagccggagg aggaaggcgg cggcgacgac gaggaagacg ccgaggcctg 60 ggccatggaa ctggcggacg tgggggcggc agccagctcg cagggagttc atgatcaagt 120 gttgcccaca ccaaatgctt catccagagt catagtacat gtggatctgg attgctttta 180 tgcacaagta gaaatgatct caaatccaga gctaaaagac aaacctttag gggttcaaca 240 gaaatatttg gtggttacct gcaactatga agctaggaaa cttggagtta agaaacttat 300 gaatgtcaga gatgcaaaag aaaagtgtcc acagttggta ttagttaatg gagaagacct 360 gacccgctac agagaaatgt cttataaggt tacagaatta ctggaagaat ttagtccagt 420 tgttgagaga cttggatttg atgaaaattt tgtggatcta acagaaatgg ttgagaagag 480 actacagcag ctgcaaagtg atgaactttc tgcggtgact gtgtcgggtc atgtatacaa 540 taatcagtct ataaacctgc ttgacgtctt gcacatcaga ctacttgttg gatctcagat 600 tgcagcagag atgcgggaag ccatgtataa tcagttgggg ctcactggct gtgctggagt 660 ggcttctaat aaactgttgg caaaattagt ttctggtgtc tttaaaccaa atcaacaaac 720 agtcttatta cctgaaagtt gtcaacatct tattcatagt ttgaatcaca taaaggaaat 780 acctggtatt ggctataaaa ctgccaaatg tcttgaagca ctgggtatca atagtgtgcg 840 tgatctccaa accttttcac ccaaaatttt agaaaaagaa ttaggaattt cagttgctca 900 gcgtatccaa aagctcagtt ttggagagga taactcccct gtgatactct caggaccacc 960 tcagtccttt agtgaagaag attcatttaa aaaatgttca tctgaagttg aagctaaaaa 1020 taagattgaa gaactacttg ctagtctttt aaacagagta tgccaagatg gaaggaagcc 1080 tcatacagtg agattaataa tccgtcggta ttcctctgag aagcactatg gtcgtgagag 1140 tcgtcagtgc cctattcctt cacatgtaat tcagaaatta gggacaggaa attatgatgt 1200 gatgacccca atggttgata tacttatgaa actttttcga aatatggtga atgtgaagat 1260 gccatttcac cttacccttc taagtgtgtg cttctgcaac cttaaagcac taaatactgc 1320 taagaaaggg cttattgatt attatttaat gccatcatta tcaactactt cacgctctgg 1380 caagcacagt tttaaaatga aagacactca tatggaagat tttcccaaag acaaagaaac 1440 aaaccgggat ttcctaccaa gtggaagaat tgaaagtaca agaactaggg agtctccact 1500 agataccaca aatttttcta aagaaaaaga cattaatgaa ttcccactct gttcacttcc 1560 tgaaggtgtt gaccaagaag tcttcaagca gcttccagta gatattcaag aagaaatcct 1620 ttctggaaaa tctagggaaa aatttcaagg gaaaggaagt gtgagttgtc cattacatgc 1680 ctctagagga gtattatctt tcttttctaa aaaacaaatg caagatattc ccataaatcc 1740 tagagatcat ttatccagta gcaaacaggt atcctctgta tctccttgtg aaccgggaac 1800 atcaggcttt aatagcagta gttcttctta catgtctagc caaaaggatt attcatatta 1860 tttagataat agattaaaag atgaacgaat aagtcaagga cctaaagaac ctcaaggatt 1920 ccactttaca aattcaaacc ctgctgtgtc tgcttttcat tcatttccaa acttgcagag 1980 tgagcaactt ttctccagaa accacactac agatagccat aagcaaacag tagcaacaga 2040 ctctcatgaa ggacttacag aaaatagaga gccagattct gttgatgaga aaattacttt 2100 cccttctgac attgatcctc aagttttcta tgaactacca gaagcagtac aaaaggaact 2160 gctggcagag tggaagagaa caggatcaga tttccacatt ggacataaat aagcatattc 2220 agcaaaaagg tctgaaaagc aagggaatac cattattttc ggattagcgg tttattaagc 2280 tcttctatat taaacactaa tagatattca ataacggagt aaactgttcc agataaagca 2340 agaatagttg caagaagtaa attctggcac aaagcgtaaa aatataacag aagaaataat 2400 gtaaaatact atcttttatg tctaaagcca ttttatatta cttttcaata aaaagaatat 2460 catggtcaaa aaaaaaaaaa aaaa 2484 <210> 531 <211> 2483 <212> DNA <213> Homo sapiens <400> 531 ccacgcgtcc gcccacgcgt ccgggcggcg gcgacgacga cgaggaagac gccgaggcct 60 gggccatgga actggcggac gtgggggcgg cagccagctc gcagggagtt catgatcaag 120 tgttgcccac accaaatgct tcatccagag tcatagtaca tgtggatctg gattgctttt 180 atgcacaagt agaaatgatc tcaaatccag agctaaaaga caaaccttta ggggttcaac 240 agaaatattt ggtggttacc tgcaactatg aagctaggaa acttggagtt aagaaactta 300 tgaatgtcag agatgcaaaa gaaaagtgtc cacagttggt attagttaat ggagaagacc 360 tgacccgcta cagagaaatg tcttataagg ttacagaatt actggaagaa tttagtccag 420 ttgttgagag acttggattt gatgaaaatt ttgtggatct aacagaaatg gttgagaaga 480 gactacagca gctgcaaagt gatgaacttt ctgcggtgac tgtgtcgggt catgtataca 540 ataatcagtc tataaacctg cttgacgtct tgcacatcag actacttgtt ggatctcaga 600 ttgcagcaga gatgcgggaa gccatgtata atcagttggg gctcactggc tgtgctggag 660 tggcttctaa taaactgttg gcaaaattag tttctggtgt ctttaaacca aatcaacaaa 720 cagtcttatt acctgaaagt tgtcaacatc ttattcatag tttgaatcac ataaaggaaa 780 tacctggtat tggctataaa actgccaaat gtcttgaagc actgggtatc aatagtgtgc 840 gtgatctcca aaccttttca cccaaaattt tagaaaaaga attaggaatt tcagttgctc 900 agcgtatcca aaagctcagt tttggagagg ataactcccc tgtgatactc tcaggaccac 960 ctcagtcctt tagtgaagaa gattcattta aaaaatgttc atctgaagtt gaagctaaaa 1020 ataagattga agaactactt gctagtcttt taaacagagt atgccaagat ggaaggaagc 1080 ctcatacagt gagattaata atccgtcggt attcctctga gaagcactat ggtcgtgaga 1140 gtcgtcagtg ccctattcct tcacatgtaa ttcagaaatt agggacagga aattatgatg 1200 tgatgacccc aatggttgat atacttatga aactttttcg aaatatggtg aatgtgaaga 1260 tgccatttca ccttaccctt ctaagtgtgt gcttctgcaa ccttaaagca ctaaatactg 1320 ctaagaaagg gcttattgat tattatttaa tgccatcatt atcaactact tcacgctctg 1380 gcaagcacag ttttaaaatg aaagacactc atatggaaga ttttcccaaa gacaaagaaa 1440 caaaccggga tttcctacca agtggaagaa ttgaaagtac aagaactagg gagtctccac 1500 tagataccac aaatttttct aaagaaaaag acattaatga attcccactc tgttcacttc 1560 ctgaaggtgt tgaccaagaa gtcttcaagc agcttccagt agatattcaa gaagaaatcc 1620 tttctggaaa atctagggaa aaatttcaag ggaaaggaag tgtgagttgt ccattacatg 1680 cctctagagg agtattatct ttcttttcta aaaaacaaat gcaagatatt cccataaatc 1740 ctagagatca tttatccagt agcaaacagg tatcctctgt atctccttgt gaaccgggaa 1800 catcaggctt taatagcagt agttcttctt acatgtctag ccaaaaggat tattcatatt 1860 atttagataa tagattaaaa gatgaacgaa taagtcaagg acctaaagaa cctcaaggat 1920 tccactttac aaattcaaac cctgctgtgt ctgcttttca ttcatttcca aacttgcaga 1980 gtgagcaact tttctccaga aaccacacta cagatagcca taagcaaaca gtagcaacag 2040 actctcatga aggacttaca gaaaatagag agccagattc tgttgatgag aaaattactt 2100 tcccttctga cattgatcct caagttttct atgaactacc agaagcagta caaaaggaac 2160 tgctggcaga gtggaagaga gcaggatcag atttccacat tggacataaa taagcatatt 2220 cagcaaaaag gtctgaaaag caagggaata ccattatttt cggattagcg gtttattaag 2280 ctcttctata ttaaacacta atagatattc aataacggag taaactgttc cagataaagc 2340 aagaatagtt gcaagaagta aattctggca caaagcgtaa aaatataaca gaagaaataa 2400 tgtaaaatac tatcttttat gtctaaagcc attttatatt acttttcaat aaaaagaata 2460 tcatggtcaa aaaaaaaaaa aaa 2483 <210> 532 <211> 2447 <212> DNA <213> Homo sapiens <400> 532 gcggcgacga cgaggaagac gccgaggcct gggccatgga actggcggac gtgggggcgg 60 cagccagctc gcagggagtt catgatcaag tgttgcccac accaaatgct tcatccagag 120 tcatagtaca tgtggatctg gattgctttt atgcacaagt agaaatgatc tcaaatccag 180 agctaaaaga caaaccttta ggggttcaac agaaatattt ggtggttacc tgcaactatg 240 aagctaggaa acttggagtt aagaaactta tgaatgtcag agatgcaaaa gaaaagtgtc 300 cacagttggt attagttaat ggagaagacc tgacccgcta cagagaaatg tcttataagg 360 ttacagaatt actggaagaa tttagtccag ttgttgagag acttggattt gatgaaaatt 420 ttgtggatct aacagaaatg gttgagaaga gactacagca gctgcaaagt gatgaacttt 480 ctgcggtgac tgtgtcgggt catgtataca ataatcagtc tataaacctg cttgacgtct 540 tgcacatcag actacttgtt ggatctcaga ttgcagcaga gatgcgggaa gccatgtata 600 atcagttggg gctcactggc tgtgctggag tggcttctaa taaactgttg gcaaaattag 660 tttctggtgt ctttaaacca aatcaacaaa cagtcttatt acctgaaagt tgtcaacatc 720 ttattcatag tttgaatcac ataaaggaaa tacctggtat tggctataaa actgccaaat 780 gtcttgaagc actgggtatc aatagtgtgc gtgatctcca aaccttttca cccaaaattt 840 tagaaaaaga attaggaatt tcagttgctc agcgtatcca aaagctcagt tttggagagg 900 ataactcccc tgtgatactc tcaggaccac ctcagtcctt tagtgaagaa gattcattta 960 aaaaatgttc atctgaagtt gaagctaaaa ataagattga agaactactt gctagtcttt 1020 taaacagagt atgccaagat ggaaggaagc ctcatacagt gagattaata atccgtcggt 1080 attcctctga gaagcactat ggtcgtgaga gtcgtcagtg ccctattcct tcacatgtaa 1140 ttcagaaatt agggacagga aattatgatg tgatgacccc aatggttgat atacttatga 1200 aactttttcg aaatatggtg aatgtgaaga tgccatttca ccttaccctt ctaagtgcgt 1260 gcttctgcaa ccttaaagca ctaaatactg ctaagaaagg gcttattgat tattatttaa 1320 tgccatcatt atcaactact tcacgctctg gcaagcacag ttttaaaatg aaagacactc 1380 atatggaaga ttttcccaaa gacaaagaaa caaaccggga tttcctacca agtggaagaa 1440 ttgaaagtac aagaactagg gagtctccac tagataccac aaatttttct aaagaaaaag 1500 gcattaatga attcccactc tgttcacttc ctgaaggtgt tgaccaagaa gtcttcaagc 1560 agcttccagt agatattcaa gaagaaatcc tttctggaaa atctagggaa aaatttcaag 1620 ggaaaggaag tgtgagttgt ccattacatg cctctagagg agtattatct ttcttttcta 1680 aaaaacaaat gcaagatatt cccataaatc ctagagatca tttatccagt agcaaacagg 1740 tatcctctgt atctccttgt gaaccgggaa catcaggctt taatagcagt agttcttctt 1800 acatgtctag ccaaaaggat tattcatatt atttagataa tagattaaaa gatgaacgaa 1860 taagtcaagg acctaaagaa cctcaaggat tccactttac aaattcaaac cctgctgtgt 1920 ctgcttttca ttcatttcca aacttgcaga gtgagcaact tttctccaga aaccacacta 1980 cagatagcca taagcaaaca gtagcaacag actctcatga aggacttaca gaaaatagag 2040 agccagattc tgttgatgag aaaattactt tcccttctga cattgatcct caagttttct 2100 atgaactacc agaagcagta caaaaggaac tgctggcaga gtggaagaga acaggatcag 2160 atttccacat tggacataaa taagcatatt cagcaaaaag gtctgaaaag caagggaata 2220 ccattatttt cggattagcg gtttattaag ctcttctata ttaaacacta atagatattc 2280 aataacggag taaactgttc cagataaagc aagaatagtt gcaagaagta aattctggca 2340 caaagcgtaa aaatataaca gaagaaataa tgtaaaatac tatcttttat gtctaaagcc 2400 attttatatt acttttcaat aaaaagaata tcatggtcaa aaaaaaa 2447 <210> 533 <211> 2475 <212> DNA <213> Homo sapiens <400> 533 gggggaggaa ggcggcggcg acgacgagga agacgccgag gcctgggcca tggaactggc 60 ggacgtgggg gcggcagcca gctcgcaggg agttcatgat caagtgttgc ccacaccaaa 120 tgcttcatcc agagtcatag tacatgtgga tctggattgc ttttatgcac aagtagaaat 180 gatctcaaat ccagagctaa aagacaaacc tttaggggtt caacagaaat atttggtggt 240 tacctgcaac tatgaagcta ggaaacttgg agttaagaaa cttatgaatg tcagagatgc 300 aaaagaaaag tgtccacagt tggtattagt taatggagaa gacctgaccc gctacagaga 360 aatgtcttat aaggttacag aattactgga agaatttagt ccagttgttg agagacttgg 420 atttgatgaa aattttgtgg atctaacaga aatggttgag aagagactac agcagctgca 480 aagtgatgaa ctttctgcgg tgactgtgtc gggtcatgta tacaataatc agtctataaa 540 cctgcttgac gtcttgcaca tcagactact tgttggatct cagattgcag cagagatgcg 600 ggaagccatg tataatcagt tggggctcac tggctgtgct ggagtggctt ctaataaact 660 gttggcaaaa ttagtttctg gtgtctttaa accaaatcaa caaacagtct tattacctga 720 aagttgtcaa catcttattc atagtttgaa tcacataaag gaaatacctg gtattggcta 780 taaaactgcc aaatgtcttg aagcactggg tatcaatagt gtgcgtgatc tccaaacctt 840 ttcacccaaa attttagaaa aagaattagg aatttcagtt gctcagcgta tccaaaagct 900 cagttttgga gaggataact cccctgtgat actctcagga ccacctcagt cctttagtga 960 agaagattca tttaaaaaat gtacatctga agttgaagct aaaaataaga ttgaagaact 1020 acttgctagt cttttaaaca gagtatgcca agatggaagg aagcctcata cagtgagatt 1080 aataatccgt cggtattcct ctgagaagca ctatggtcgt gagagtcgtc agtgccctat 1140 tccttcacat gtaattcaga aattagggac aggaaattat gatgtgatga ccccaatggt 1200 tgatatactt atgaaacttt ttcgaaatat ggtgaatgtg aagatgccat ttcaccttac 1260 ccttctaagt gtgtgcttct gcaaccttaa agcactaaat actgctaaga aagggcttat 1320 tgattattat ttaatgccat cattatcaac tacttcacgc tctggcaagc acagttttaa 1380 aatgaaagac actcatatgg aagattttcc caaagacaaa gaaacaaacc gggatttcct 1440 accaagtgga agaattgaaa gtacaagaac tagggagtct ccactagata ccacaaattt 1500 ttctaaagaa aaagacatta atgaattccc actctgttca cttcctgaag gtgttgacca 1560 agaagtctcc aagcagcttc cagtagatat tcaagaagaa atcctttctg gaaaatctag 1620 ggaaaaattt caagggaaag gaagtgtgag ttgtccatta catgcctcta gaggagtatt 1680 atctttcttt tctaaaaaac aaatgcaaga tattcccata aatcctagag atcatttatc 1740 cagtagcaaa caggtatcct ctgtatctcc ttgtgaaccg ggaacatcag gctttaatag 1800 cagtagttct tcttacatgt ctagccaaaa ggattattca tattatttag ataatagatt 1860 aaaagatgaa cgaataagtc aaggacctaa agaacctcaa ggattccact ttacaaattc 1920 aaaccctgct gtgtctgctt ttcattcatt tccaaacttg cagagtgagc aacttttctc 1980 cagaaaccac actacagata gccataagca aacagtagca acagactctc atgaaggact 2040 tacagaaaat agagagccag attctgttga tgagaaaatt actttccctt ctgacattga 2100 tcctcaagtt ttctatgaac taccagaagc agtacaaaag gaactgctgg cagagtggaa 2160 gagaacagga tcagatttcc acattggaca taaataagca tattcagcaa aaaggtctga 2220 aaagcaaggg aataccatta ttttcggatt agcggtttat taagctcttc tatattaaac 2280 actaatagat attcaataac ggagtaaact gttccagata aagcaagaat agttgcaaga 2340 agtaaattct ggcacaaagc gtaaaaatat aacagaagaa ataatgtaaa atactatctt 2400 ttatgtctaa agccatttta tattactttt caataaaaag aatatcatgg tcaaaaaaaa 2460 aaaaaaaaaa aaaac 2475 <210> 534 <211> 2746 <212> DNA <213> Homo sapiens <400> 534 ccacgcgtcc ggccggagga ggaaggcggc ggcgacgacg aggaagacgc cgaggcctgg 60 gccatggaac tggcggacgt gggggcggca gccagctcgc agggtgcgcc gcagccagag 120 gagccagcgg cctccttggg tgtaaatgag aagggtgggg caggcggacg ctcggggcgg 180 cggccactgg ggcgcgaccg tccccgcccc actcggctcc tctaagagag ggctgcctcc 240 ctctgccttg tgttacgcgg cgggtacctc tagaggaatg gcttcaccca gcaggagtag 300 ggtggggcgc gtccacacta caaatacgtg tcgagggttt atctgcgccg tcctttcctc 360 tgtgaggggc gaggtggggc gggaatccct cagccagccc gacgaaaact gcagaggctt 420 ctgggccttt taactttgga gaagttgagg accttgtcgc tcatttggca gaaggggttc 480 aacagaaata tttggtggtt acctgcaact atgaagctag gaaacttgga gttaagaaac 540 ttatgaatgt cagagatgca aaagaaaagt gtccacagtt ggtattagtt aatggagaag 600 acctgacccg ctacagagaa atgtcttata aggttacaga attactggaa gaatttagtc 660 cagttgttga gagacttgga tttgatgaaa attttgtgga tctaacagaa atggttgaga 720 agagactaca gcagctgcaa agtgatgaac tttctgcggt gactgtgtcg ggtcatgtat 780 acaataatca gtctataaac ctgcttgacg tcttgcacat cagactactt gttgaatctc 840 agattgcagc agagatgcgg gaagccatgt ataatcagtt ggggctcact ggctgtgctg 900 gagtggcttc taataaactg ttggcaaaat tagtttctgg tgtctttaaa ccaaatcaac 960 aaacagtctt attacctgaa agttgtcaac atcttattca tagtttgaat cacataaagg 1020 aaatacctgg tattggctat aaaactgcca aatgtcttga agcactgggt atcaatagtg 1080 tgcgtgatct ccaaaccttt tcacccaaaa ttttagaaaa agaattagga atttcagttg 1140 ctcagcgtat ccaaaagctc agttttggag aggataactc ccctgtgata ctctcaggac 1200 cacctcagtc ctttagtgaa gaagattcat ttaaaaaatg ttcatctgaa gttgaagcta 1260 aaaataagat tgaagaacta cttgctagtc ttttaaacag agtatgccaa gatggaagga 1320 agcctcatac agtgagatta ataatccgtc ggtattcctc tgagaagcac tatggtcgtg 1380 agagtcgtca gtgccctatt ccttcacatg taattcagaa attagggaca ggaaattatg 1440 atgtgatgac cccaatggtt gatatactta tgaaactttt tcgaaatatg gtgaatgtga 1500 agatgccatt tcaccttacc cttctaagtg tgtgcttctg caaccttaaa gcactaaata 1560 ctgctaagaa agggcttatt gattattatt taatgccatc attatcaact acttcacgct 1620 ctggcaagca cagttttaaa atgaaagaca ctcatatgga agattttccc aaagacaaag 1680 aaacaaaccg ggatttccta ccaagtggaa gaattgaaag tacaagaact agggagtctc 1740 cactagatac cacaaatttt tctaaagaaa aagacattaa tgaattccca ctctgttcac 1800 ttcctgaagg tgttgaccaa gaagtcttca agcagcttcc agtagatatt caagaagaaa 1860 tcctttctgg aaaatctagg gaaaaatttc aagggaaagg aagtgtgagt tgtccattac 1920 atgcctctag aggagtatta tctttctttt ctaaaaaaca aatgcaagat attcccataa 1980 atcctagaga tcatttatcc agtagcaaac aggtatcctc tgtatctcct tgtgaaccgg 2040 gaacatcagg ctttaatagc agtagttctt cttacatgtc tagccaaaag gattattcat 2100 attatttaga taatagatta aaagatgaac gaataagtca aggacctaaa gaacctcaag 2160 gattccactt tacaaattca aaccctgctg tgtctgcttt tcattcattt ccaaacttgc 2220 agagtgagca acttttctcc agaaaccaca ctacagatag ccataagcaa acagtagcaa 2280 cagactctca tgaaggactt acagaaaata gagagccaga ttctgttgat gagaaaatta 2340 ctttcccttc tgacattgat cctcaagttt tctatgaact accagaagca gtacaaaagg 2400 aactgctggc agagtggaag agaacaggat cagatttcca cattggacat aaataagcat 2460 attcagcaaa aaggtctgaa aagcaaggga ataccattat tttcggatta gcggtttatt 2520 aagctcttct atattaaaca ctaatagata ttcaataacg gagtaaactg ttccagataa 2580 agcaagaata gttgcaagaa gtaaattctg gcacaaagcg taaaaatata acagaagaaa 2640 taatgtaaaa tactatcttt tatgtctaaa gccattttat attacttttc aataaaaaga 2700 atatcatggt caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa 2746 <210> 535 <211> 1755 <212> DNA <213> Homo sapiens <400> 535 tgtcttgaag cactgggtat caatagtgtg cgtgatctcc aaaccttttc acccaaaatt 60 ttagaaaaag aattaggaat ttcagttgct cagcgtatcc aaaagctcag ttttggagag 120 gataactccc ctgtgatact ctcaggacca cctcagtgag tacaatagct tgcagataaa 180 aaactgttaa tataaaagtg aactaaatgg ctcaaactaa ggacaagagt cctttagtga 240 agaagattca tttaaaaaat gttcatctga agttgaagct aaaaataaga ttgaagaact 300 acttgctagt cttttaaaca gagtatgcca agatggaagg aagcctcata cagtgagatt 360 aataatccgt cggtattcct ctgagaagca ctatggtcgt gagagtcgtc agtgccctat 420 tccttcacat gtaattcaga aattagggac aggaaattat gatgtgatga ccccaatggt 480 tgatatactt atgaaacttt ttcgaaatat ggtgaatgtg aagatgccat ttcaccttac 540 ccttctaagt gtgtgcttct gcaaccttaa agcactaaat actgctaaga aagggcttat 600 tgattattat ttaatgccat cattatcaac tacttcacgc tctggcaagc acagttttaa 660 aatgaaagac actcatatgg aagattttcc caaagacaaa gaaacaaacc gggatttcct 720 accaagtgga agaattgaaa gtacaagaac tagggagtct ccactagata ccacaaattt 780 ttctaaagaa aaagacatta atgaattccc actctgttca cttcctgaag gtgttgacca 840 agaagtcttc aagcagcttc cagtagatat tcaagaagaa atcctttctg gaaaatctag 900 ggaaaaattt caagggaaag gaagtgtgag ttgtccatta catgcctcta gaggagtatt 960 atctttcttt tctaaaaaac aaatgcaaga tattcccata aatcctagag atcatttatc 1020 cagtagcaaa caggtatcct ctgtatctcc ttgtgaaccg ggaacatcag gctttaatag 1080 cagtagttct tcttacatgt ctagccaaaa ggattattca tattatttag ataatagatt 1140 aaaagatgaa cgaataagtc aaggacctaa agaacctcaa ggattccact ttacaaattc 1200 aaaccctgct gtgtctgctt ttcattcatt tccaaacttg cagagtgagc aacttttctc 1260 cagaaaccac actacagata gccataagca aacagtagca acagactctc atgaaggact 1320 tacagaaaat agagagccag attctgttga tgagaaaatt actttccctt ctgacattga 1380 tcctcaagtt ttctatgaac taccagaagc agtacaaaag gaactgctgg cagagtggaa 1440 gagaacagga tcagatttcc acattggaca taaataagca tattcagcaa aaaggtctga 1500 aaagcaaggg aataccatta ttttcggatt agcggtttat taagctcttc tatattaaac 1560 actaatagat attcaataac ggagtaaact gttccagata aagcaagaat agttgcaaga 1620 agtaaattct ggcacaaagc gtaaaaatat aacagaagaa ataatgtaaa atactatctt 1680 ttatgtctaa agccatttta tattactttt caataaaaag aatatcatgg tcaaaaaaaa 1740 aaaaaaaaaa aaaaa 1755 <210> 536 <211> 2536 <212> DNA <213> Homo sapiens <400> 536 gacgacgagg aagacgccga ggcctgggcc atggaactgg cggacgtggg ggcggcagcc 60 agctcgcagg gtgcgccgca gccagaggag ccagcggcct ccttgggtgt aaatgagaag 120 ggtggggcag gcggacgctc ggggcggcgg ccactggggc gcgaccgtcc ccgccccact 180 cggctcctct aagagagggc tgcctccctc tgccttgtgt tacgcggcgg gtacctctag 240 aggaatggct tcacccagca ggagtagggt ggggcgcgtc cacactacaa atacgtgtcg 300 agggtttatc tgcgccgtcc tttcctctgt gaggggcgag gtggggcggg aatccctcag 360 ccagcccgac gaaaactgca gaggcttctg ggccttttaa ctttggagaa gttgaggacc 420 ttgtcgctca tttggcagaa ggtgggaccc ggatctcagt cctggcagga agggatggct 480 cagaacctag gcggagtcag gtccgctgtg gtcacgtctc cggtgaccca cttccagctc 540 tggtctttac cttgtaccgc ccacctcagg gcctggatgt aaaggcaccg gttctcattt 600 cctgctggtt ttgtttcatt cattaattta gagacaaggt ctccctgcag cctcgaaccc 660 ctgggctcaa gtgatcctcc gccccagcct ctccgtcccg agtagctggg acagcaggca 720 cgtgccacca cacctggctg attttcagat ttttttagat caggtgtagc tgtgttgtcc 780 aggctggtct caaactccag ccacaagcga tccttccacc tcagcttcga aaagtattgg 840 gattacagta gttagccatc gtgcctggcc ttttaaattt tggaacttta ggtttacctg 900 aaagttgcag agctagatcc ccctagtgtt aacataaact cagtacattt gtcaaaacta 960 ggaaattaac attggtataa tactattaat tgaactacac gctttattaa tattctacca 1020 gtttttctgc taacgttcat tttctgttcc aggatcccaa ccagaatatt gtattgtatt 1080 ttgcctgtct tgtttttagc cagtgttgag agaaggagtc gcctctgtca ttccctcccc 1140 gacaaataat gacctaacaa ctttttaaaa tcaaagaact attcagtctt tcaatttagt 1200 gaatatttat tggtggtctg ttatgtccta gacactgttt taggcactgg cgatttagca 1260 ttaaaccaga taatcctgct gccatgggag ctaaaaatag cccacacttg tacccactgg 1320 ttgtcttttg ccattttgta tttcagtttt tgttggtttg tttgttttaa atgtaagggc 1380 atgctgctta gaataatttt caagctgtgt gaaaatcaac gtcatttcaa cttttctgcc 1440 ccttctggtt tacactaaga gctactataa acttccaggt gatagtatta gctctttcat 1500 catccattat ttatcacatt ttttcccttc aaacttatta ctatcctgag aaaaacgcag 1560 tgcacaaaca gtaattaaga ggactgaaga ccctacccta agtggagttt catgtctttg 1620 taatttttcg atgctttcac acataatcca ggagaaaaca cgtcactctg cattcttcct 1680 tcacaggtac catgttttaa ggaactgtca gttgctcaga gataataagc agcctgaatt 1740 tctttttatt tctttgcata ttgtgcagga gttcatgatc aagtgttgcc cacaccaaat 1800 gcttcatcca gagtcatagt acatgtggat ctggattgct tttatgcaca agtagaaatg 1860 atctcaaatc cagagctaaa agacaaacct ttaggggttc aacagaaata tttggtggtt 1920 acctgcaact atgaagctag gaaacttgga gttaagaaac ttatgaatgt cagagatgca 1980 aaagaaaagt gtccacagtt ggtattagtt aatggagaag acctgacccg ctacagagaa 2040 atgtcttata aggttacaga attactggaa gaatttagtc cagttgttga gagacttgga 2100 tttgatgaaa attttgtgga tctaacagaa atggttgaga agagactaca gcagctgcaa 2160 agtgatgaac tttctgcggt gactgtgtcg ggtcatgtat acaataatca gtctataaac 2220 ctgcttgacg tcttgcacat cagactactt gttggatctc agattgcagc agagatgcgg 2280 gaagccatgt ataatcagtt ggggctcact ggctgtgctg gagtggcttc taataaactg 2340 ttggcaaaat tagtttctgg tgtctttaaa ccaaatcaac aaacagtctt attacctgaa 2400 agttgtcaac atcttattca tagtttgaat cacataaagg aaatacctgg tattggctat 2460 aaaactgcca aatgtcttga agcactgggt atcaatagtg tgcgtgatct ccaaaccttt 2520 tcacccaaaa ttttag 2536 <210> 537 <211> 2254 <212> DNA <213> Homo sapiens <400> 537 gggaattctg aaagccgctg gcggaccgcg cgcagcggcc agagaccgag ccctaaggag 60 agtgcggcgc ttcccgaggc gtgcagctgg gaactgcaac tcatctgggt tgtgcgcaga 120 aggctggggc aagcgagtag agaagtggag cgtaagccag gggcgttggg ggccgtgcgg 180 gtcgggcgcg tgccacgccc gcggggtgaa gtcggagcgc ggggcctgct ggagagagga 240 gcgctgcgga ccgagtaatg gcaatgcaga tgcagcttga agcaaatgca gatacttcag 300 tggaagaaga aagctttggc ccacaaccca tttcacggtt agagcagtgt ggcataaatg 360 ccaacgatgt gaagaaattg gaagaagctg gattccatac tgtggaggct gttgcctatg 420 cgccaaagaa ggagctaata aatattaagg gaattagtga agccaaagct gataaaattc 480 tggctgaggc agctaaatta gttccaatgg gtttcaccac tgcaactgaa ttccaccaaa 540 ggcggtcaga gatcatacag attactactg gctccaaaga gcttgacaaa ctacttcaag 600 gtggaattga gactggatct atcacagaaa tgtttggaga attccgaact gggaagaccc 660 agatctgtca tacgctagct gtcacctgcc agcttcccat tgaccggggt ggaggtgaag 720 gaaaggccat gtacattgac actgagggta cctttaggcc agaacggctg ctggcagtgg 780 ctgagaggta tggtctctct ggcagtgatg tcctggataa tgtagcatat gctcgagcgt 840 tcaacacaga ccaccagacc cagctccttt atcaagcatc agccatgatg gtagaatcta 900 ggtatgcact gcttattgta gacagtgcca ccgcccttta cagaacagac tactcgggtc 960 gaggtgagct ttcagccagg cagatgcact tggccaggtt tctgcggatg cttctgcgac 1020 tcgctgatga gtttggtgta gcagtggtaa tcactaatca ggtggtagct caagtggatg 1080 gagcagcgat gtttgctgct gatcccaaaa aacctattgg aggaaatatc atcgcccatg 1140 catcaacaac cagattgtat ctgaggaaag gaagagggga aaccagaatc tgcaaaatct 1200 acgactctcc ctgtcttcct gaagctgaag ctatgttcgc cattaatgca gatggagtgg 1260 gagatgccaa agactgaatc attgggtttt tcctctgtta aaaaccttaa gtgctgcagc 1320 ctaatgagag tgcactgctc cctggggttc tctacaggcc tcttcctgtt gtgactgcca 1380 ggataaagct tccgggaaaa cagctattat atcagctttt ctgatggtat aaacaggaga 1440 caggtcagta gtcacaaact gatctaaaat gtttattcct tctgtagtgt attaatctct 1500 gtgtgttttc tttggttttg gaggaggggt atgaagtatc tttgacatgg tgccttagga 1560 atgacttggg tttaacaagc tgtctactgg acaatcttat gtttccaaga gaactaaagc 1620 tggagagacc tgacccttct ctcacttcta aattaatggt aaaataaaat gcctcagcta 1680 tgtagcaaag ggaatgggtc tgcacagatt ctttttttct gtcagtaaaa ctctcaagca 1740 ggtttttaag ttgtctgtct gaatgatctt gtgtaagggt ttggttatgg agtcttgtgc 1800 caaacctact aggccattag cccttcacca tctacctgct tggtctttca ttgctaagac 1860 taactcaaga taatcctaga gtcttaaagc atttcaggcc agtgtggtgt cttgcgcctg 1920 tactcccagc actttgggag gccgaggcag gtggatcgct tgagccagga gttttaagtc 1980 cagcttggcc aagatggtga aatcccatct ctacaaaaaa tgcagaactt aatctggaca 2040 cactgttaca cgtgcctgta gtcccagcta ctctatagcc tgaggtggga gaatcactta 2100 agcctggaag gtggaagttg cagtgagtcg agattgcact gctgcattcc agccagggtg 2160 acagagtgag accatgtttc aaacaagaaa catttcagag ggcaagtaaa cagatttgat 2220 tgtgaggctt ctaataaagt agttattagt agtg 2254 <210> 538 <211> 2229 <212> DNA <213> Homo sapiens <400> 538 ccgcgcgcag cggccagaga ccgagcccta aggagagtgc ggcgcttccc gaggcgtgca 60 gctgggaact gcaactcatc tgggttgtgc gcagaaggct ggggcaagcg agtagagaag 120 tggagcgtaa gccaggggcg ttgggggccg tgcgggtcgg gcgcgtgcca cgcccgcggg 180 gtgaagtcgg agcgcggggc ctgctggaga gaggagcgct gcggaccgag taatggcaat 240 gcagatgcag cttgaagcaa atgcagatac ttcagtggaa gaagaaagct ttggcccaca 300 acccatttca cggttagagc agtgtggcat aaatgccaac gatgtgaaga aattggaaga 360 agctggattc catactgtgg aggctgttgc ctatgcgcca aagaaggagc taataaatat 420 taagggaatt agtgaagcca aagctgataa aattctggct gaggcagcta aattagttcc 480 aatgggtttc accactgcaa ctgaattcca ccaaaggcgg tcagagatca tacagattac 540 tactggctcc aaagagcttg acaaactact tcaaggtgga attgagactg gatctatcac 600 agaaatgttt ggagaattcc gaactgggaa gacccagatc tgtcatacgc tagctgtcac 660 ctgccagctt cccattgacc ggggtggagg tgaaggaaag gccatgtaca ttgacactga 720 gggtaccttt aggccagaac ggctgctggc agtggctgag aggtatggtc tctctggcag 780 tgatgtcctg gataatgtag catatgctcg agcgttcaac acagaccacc agacccagct 840 cctttatcaa gcatcagcca tgatggtaga atctaggtat gcactgctta ttgtagacag 900 tgccaccgcc ctttacagaa cagactactc gggtcgaggt gagctttcag ccaggcagat 960 gcacttggcc aggtttctgc ggatgcttct gcgactcgct gatgagtttg gtgtagcagt 1020 ggtaatcact aatcaggtgg tagctcaagt ggatggagca gcgatgtttg ctgctgatcc 1080 caaaaaacct attggaggaa atatcatcgc ccatgcatca acaaccagat tgtatctgag 1140 gaaaggaaga ggggaaacca gaatctgcaa aatctacgac tctccctgtc ttcctgaagc 1200 tgaagctatg ttcgccatta atgcagatgg agtgggagat gccaaagact gaatcattgg 1260 gtttttcctc tgttaaaaac cttaagtgct gcagcctaat gagagtgcac tgctccctgg 1320 ggttctctac aggcctcttc ctgttgtgac tgccaggata aagcttccgg gaaaacagct 1380 attatatcag cttttctgat ggtataaaca ggagacaggt cagtagtcac aaactgatct 1440 aaaatgttta ttccttctgt agtgtattaa tctctgtgtg ttttctttgg ttttggagga 1500 ggggtatgaa gtatctttga catggtgcct taggaatgac ttgggtttaa caagctgtct 1560 actggacaat cttatgtttc caagagaact aaagctggag agacctgacc cttctctcac 1620 ttctaaatta atggtaaaat aaaatgcctc agctatgtag caaagggaat gggtctgcac 1680 agattctttt tttctgtcag taaaactctc aagcaggttt ttaagttgtc tgtctgaatg 1740 atcttgtgta agggtttggt tatggagtct tgtgccaaac ctactaggcc attagccctt 1800 caccatctac ctgcttggtc tttcattgct aagactaact caagataatc ctagagtctt 1860 aaagcatttc aggccagtgt ggtgtcttgc gcctgtactc ccagcacttt gggaggccga 1920 ggcaggtgga tcgcttgagc caggagtttt aagtccagct tggccaagat ggtgaaatcc 1980 catctctaca aaaaatgcag aacttaatct ggacacactg ttacacgtgc ctgtagtccc 2040 agctactcta tagcctgagg tgggagaatc acttaagcct ggaaggtgga agttgcagtg 2100 agtcgagatt gcactgctgc attccagcca gggtgacaga gtgagaccat gtttcaaaca 2160 agaaacattt cagagggcaa gtaaacagat ttgattgtga ggcttctaat aaagtagtta 2220 ttagtagtg 2229 <210> 539 <211> 1645 <212> DNA <213> Homo sapiens <400> 539 gaattccggt aaggagagtg cggcgcttcc cgaggcgtgc agctgggaac tgcaactcat 60 ctgggttgtg cgcagaaggc tggggcaagc gagtagagaa gtggagcgta agccaggggg 120 cttgggggcc gtgcgggcgg gtcgcgtgca gccccgcggg gtgaagtcgg agcgcggggc 180 ctgctggaga gaggagcgct gcgaccgagt aatggcaatg cagatgcagc ttgaagcaaa 240 tgcagatact tcagtggaag aagaaagctt tggcccacaa cccatttcac ggttagagca 300 gtgtggcata aatgccaacg atgtgaagaa attggaagaa gctggattcc atactgtgga 360 ggctgttgcc tatgcgccaa agaaggagct aataaatatt aagggaatta gtgaagccaa 420 agctgataaa attctggctg aggcagctaa attagttcca atgggtttca ccactgcaac 480 tgaattccac caaaggcggt cagagatcat acagattact actggctcca aagagcttga 540 caaactactt caaggtggaa ttgagactgg atctatcaca gaaatgtttg gagaattccg 600 aactgggaag acccagatct gtcatacgct agctgtcacc tgccagcttc ccattgaccg 660 gggtggaggt gaaggaaagg ccatgtacat tgacactgag ggtaccttta ggccagaacg 720 gctgctggca gtggctgaga ggtatggtct ctctggcagt gatgtcctgg ataatgtagc 780 atatgctcga gcgttcaaca cagaccacca gacccagctc ctttatcaag catcagccat 840 gatggtagaa tctaggtatg cactgcttat tgtagacagt gccaccgccc tttacagaac 900 agactactcg ggtcgaggtg agctttcagc caggcagatg cacttggcca ggtttctgcg 960 gatgcttctg cgactcgctg atgagtttgg tgtagcagtg gtaatcacta atcaggtggt 1020 agctcaagtg gatggagcag cgatgtttgc tgctgatccc aaaaaaccta ttggaggaaa 1080 tatcatcgcc catgcatcaa caaccagatt gtatctgagg aaaggaagag gggaaaccag 1140 aatctgccaa atctacgact ctccctgtct tcctgaagct gaagctatgt tcgccattaa 1200 tgcagatgga gtgggagatg ccaaagactg aatcattggg tttttcctct gttaaaaacc 1260 ttaagtgctg cagcctaatg agagtgcact gctccctggg gttctctaca ggcctcttcc 1320 tgttgtgact gccaggataa agcttccggg aaaacagcta ttatatcagc ttttctgatg 1380 gtataaacag gagacaggtc agtagtcaca aactgatcta aaatggttta ttccttctgt 1440 agtgtattaa tctctgtgtg ttttctttgg ttttggagga gggtatgaag tatctttgac 1500 atggtgcctt aggaatgact tgggtttaac aagctgtcta ctggacaatc ttatgtttcc 1560 aagagaacta aagctggaga gacctgaccc ttctctcact tctaaattaa tggtaaaata 1620 aaagtcctca gctatgtagc aaagg 1645 <210> 540 <211> 1963 <212> DNA <213> Homo sapiens <400> 540 gggaattctg aaagccgctg gcggaccgcg cgcagcggcc agagaccgag ccctaaggag 60 agtgcggcgc ttcccgaggc gtgcagctgg gaactgcaac tcatctgggt tgtgcgcaga 120 aggctggggc aagcgagtag agaagtggag cgtaagccag gggcgttggg ggccgtgcgg 180 gtcgggcgcg tgccacgccc gcggggtgaa gtcggagcgc ggggcctgct ggagagagga 240 gcgctgcgga ccgagtaatg gcaatgcaga tgcagcttga agcaaatgca gatacttcag 300 tggaagaaga aagctttggc ccacaaccca tttcacggtt agagcagtgt ggcataaatg 360 ccaacgatgt gaagaaattg gaagaagctg gattccatac tgtggaggct gttgcctatg 420 cgccaaagaa ggagctaata aatattaagg gaattagtga agccaaagct gataaaattc 480 tggcagtggc tgagaggtat ggtctctctg gcagtgatgt cctggataat gtagcatatg 540 ctcgagcgtt caacacagac caccagaccc agctccttta tcaagcatca gccatgatgg 600 tagaatctag gtatgcactg cttattgtag acagtgccac cgccctttac agaacagact 660 actcgggtcg aggtgagctt tcagccaggc agatgcactt ggccaggttt ctgcggatgc 720 ttctgcgact cgctgatgag tttggtgtag cagtggtaat cactaatcag gtggtagctc 780 aagtggatgg agcagcgatg tttgctgctg atcccaaaaa acctattgga ggaaatatca 840 tcgcccatgc atcaacaacc agattgtatc tgaggaaagg aagaggggaa accagaatct 900 gcaaaatcta cgactctccc tgtcttcctg aagctgaagc tatgttcgcc attaatgcag 960 atggagtggg agatgccaaa gactgaatca ttgggttttt cctctgttaa aaaccttaag 1020 tgctgcagcc taatgagagt gcactgctcc ctggggttct ctacaggcct cttcctgttg 1080 tgactgccag gataaagctt ccgggaaaac agctattata tcagcttttc tgatggtata 1140 aacaggagac aggtcagtag tcacaaactg atctaaaatg tttattcctt ctgtagtgta 1200 ttaatctctg tgtgttttct ttggttttgg aggaggggta tgaagtatct ttgacatggt 1260 gccttaggaa tgacttgggt ttaacaagct gtctactgga caatcttatg tttccaagag 1320 aactaaagct ggagagacct gacccttctc tcacttctaa attaatggta aaataaaatg 1380 cctcagctat gtagcaaagg gaatgggtct gcacagattc tttttttctg tcagtaaaac 1440 tctcaagcag gtttttaagt tgtctgtctg aatgatcttg tgtaagggtt tggttatgga 1500 gtcttgtgcc aaacctacta ggccattagc ccttcaccat ctacctgctt ggtctttcat 1560 tgctaagact aactcaagat aatcctagag tcttaaagca tttcaggcca gtgtggtgtc 1620 ttgcgcctgt actcccagca ctttgggagg ccgaggcagg tggatcgctt gagccaggag 1680 ttttaagtcc agcttggcca agatggtgaa atcccatctc tacaaaaaat gcagaactta 1740 atctggacac actgttacac gtgcctgtag tcccagctac tctatagcct gaggtgggag 1800 aatcacttaa gcctggaagg tggaagttgc agtgagtcga gattgcactg ctgcattcca 1860 gccagggtga cagagtgaga ccatgtttca aacaagaaac atttcagagg gcaagtaaac 1920 agatttgatt gtgaggcttc taataaagta gttattagta gtg 1963 <210> 541 <211> 1849 <212> DNA <213> Homo sapiens <400> 541 ctggaacccg gaagcggcag cgcggcgcga cccggcgggc gggctctggg cgcgggaatc 60 ccggcggatc ccgggcgggc ggatgacccc cagccctacc cttggtgccg cctcctcctc 120 tctcctttct cctccggcag ccagcgcgcc tgtgtcctct ctaggaaggg gtaggggagg 180 ggcgtctgga gaggaccccc cgcgaatgcc cacgtgacgt gcagtccccc tggggctgtt 240 ccggcctgcg gggaacatgg gcgtgctcag ggtcggactg tgccctggcc ttaccgagga 300 gatgatccag cttctcagga gccacaggat caagacagtg gtggacctgg tttctgcaga 360 cctggaagag gtagctcaga aatgtggctt gtcttacaag gccctggttg ccctgaggcg 420 ggtgctgctg gctcagttct cggctttccc cgtgaatggc gctgatctcc acgaggaact 480 gaagacctct actgccatcc tgtccactgg cattggcagt cttgataaac tgcttgatgc 540 tggtctctat actggagaag tgactgaaat tgtaggaggc ccaggtagcg gcaaaactca 600 ggtatgtctc tgtatggcag caaatgtggc ccatggcctg cagcaaaacg tcctatatgt 660 agattccaat ggagggctga cagcttcccg cctcctccag ctgcttcagg ctaaaaccca 720 ggatgaggag gaacaggcag aagctctccg gaggatccag gtggtgcatg catttgacat 780 cttccagatg ctggatgtgc tgcaggagct ccgaggcact gtggcccagc aggtgactgg 840 ttcttcagga actgtgaagg tggtggttgt ggactcggtc actgcggtgg tttccccact 900 tctgggaggt cagcagaggg aaggcttggc cttgatgatg cagctggccc gagagctgaa 960 gaccctggcc cgggaccttg gcatggcagt ggtggtgacc aaccacataa ctcgagacag 1020 ggacagcggg aggctcaaac ctgccctcgg acgctcctgg agctttgtgc ccagcactcg 1080 gattctcctg gacaccatcg agggagcagg agcatcaggc ggccggcgca tggcgtgtct 1140 ggccaaatct tcccgacagc caacaggttt ccaggagatg gtagacattg ggacctgggg 1200 gacctcagag cagagtgcca cattacaggg tgatcagaca tgacctgtgc tgttgtttgg 1260 gaaacaggga agcattgggg acccctccca acttttcttc ccagtaacgc ctgctgttta 1320 ctgccacctg gcactggtga ctacagacgt tctcaggctg gccagaagag acatcttggg 1380 ttccttggcc tcactctctg taagcatata aaccacaggc gaaagaggat gctgcattgc 1440 gaggacccag aaattcatac tggtgccacg tttccttccc ttatttctaa cgtgtatgtt 1500 tctggtggaa accaagttca ccctggctgg gagcatctct gatgaggcat gctggcgact 1560 ggatggataa tcctgtgcat caccattgtg tcctgtgctc cctcctagcg cagtggccaa 1620 gccgggaaag cctctaactt gcctttgctg ctgctgcctt ttttttcttt tgtctctgcc 1680 tttccatttg ttagatgggg gcccactctt ccttagctct gtctctgagt tactgggtgg 1740 aaataagctt ataaatgaaa tactcttctt catctctgtt ttgctcttaa aaatataaaa 1800 aggcaattcc ccgaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa 1849 <210> 542 <211> 1712 <212> DNA <213> Homo sapiens <400> 542 ggcacgaggc gcctgtgtcc tctctaggaa ggggtagggg aggggcgtct ggagaggacc 60 ccccgcgaat gcccacgtga cgtgcagtcc ccctggggct gttccggcct gcggggaaca 120 tgggcgtgct cagggtcgga ctgtgccctg gccttaccga ggagatgatc cagcttctca 180 ggagccacag gatcaagaca gtggtggacc tggtttctgc agacctggaa gaggtagctc 240 agaaatgtgg cttgtcttac aaggccctgg ttgccctgag gcgggtgctg ctggctcagt 300 tctcggcttt ccccgtgaat ggcgctgatc tctacgagga actgaagacc tctactgcca 360 tcctgtccac tggcattggc agtcttgata aactgcttga tgctggtctc tatactggag 420 aagtgactga aattgtagga ggcccaggta gcggcaaaac tcaggtatgt ctctgtatgg 480 cagcaaatgt ggcccatggc ctgcagcaaa acgtcctata tgtagattcc aatggagggc 540 tgacagcttc ccgcctcctc cagctgcttc aggctaaaac ccaggatgag gaggaacagg 600 cagaagctct ccggaggatc caggtggtgc atgcatttga catcttccag atgctggatg 660 tgctgcagga gctccgaggc actgtggccc agcaggtgac tggttcttca ggaactgtga 720 aggtggtggt tgtggactcg gtcactgcgg tggtttcccc acttctggga ggtcagcaga 780 gggaaggctt ggccttgatg atgcagctgg cccgagagct gaagaccctg gcccgggacc 840 ttggcatggc agtggtggtg accaaccaca taactcgaga cagggacagc gggaggctca 900 aacctgccct cggacgctcc tggagctttg tgcccagcac tcggattctc ctggacacca 960 tcgagggagc aggagcatca ggcggccggc gcatggcgtg tctggccaaa tcttcccgac 1020 agccaacagg tttccaggag atggtagaca ttgggacctg ggggacctca gagcagagtg 1080 ccacattaca gggtgatcag acatgacctg tgctgttgtt tgggaaacag ggaagcattg 1140 gggacccctc ccaacttttc ttcccagtaa cgcctgctgt ttactgccac ctggcactgg 1200 tgactacaga cgttctcagg ctggccagaa gagacatctt gggttccttg gcctcactct 1260 ctgtaagcat ataaaccaca ggcgaaagag gatgctgcat tgcgaggacc cagaaattca 1320 tactggtgcc acgtttcctt cccttatttc taacgtgtat gtttctggtg gaaaccaagt 1380 tcaccctggc tgggagcatc tctgatgagg catgctggcg actggatgga taatcctgtg 1440 catcaccatt gtgtcctgtg ctccctccta gcgcagtggc caagccggga aagcctctaa 1500 cttgcctttg ctgctgctgc cttttttttc ttttgtctct gcctttccat ttgttagatg 1560 ggggcccact cttccttagc tctgtctctg agttactggg tggaaataag cttataaatg 1620 aaatactctt cttcatctct gttttgctct taaaaatata aaaaggcaat tccccgaaaa 1680 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa 1712 <210> 543 <211> 1541 <212> DNA <213> Homo sapiens <400> 543 ctcctttctc ctccggcagc cagcgcgcct gtgtcctctc taggaagggg taggggaggg 60 gcgtctggag aggacccccc gcgaatgccc acgtgacgtg cagtccccct ggggctgttc 120 cggcctgcgg ggaacatggg cgtgctcagg gtcggactgt gccctggcct taccgaggag 180 atgatccagc ttctcaggag ccacaggatc aagacagtgg tggacctggt ttctgcagac 240 ctggaagagg tagctcagaa atgtggcttg tcttacaagg ccctggttgc cctgaggcgg 300 gtgctgctgg ctcagttctc ggctttcccc gtgaatggcg ctgatctcta cgaggaactg 360 aagacctcca ctgccatcct gtccactggc attggcagtc ttgataaact gcttgatgct 420 ggtctctata ctggagaagt gactgaaatt gtaggaggcc caggtagcgg caaaactcag 480 gtatgtctct gtatggcagc aaatgtggcc catggcctgc agcaaaacgt cctatatgta 540 gattccaatg gagggctgac agcttcccgc ctcctccagc tgcttcaggc taaaacccag 600 gatgaggagg aacaggcaga agctctccgg aggatccagg tggtgcatgc atttgacatc 660 ttccagatgc tggatgtgct gcaggagctc cgaggcactg tggcccagca ggtgactggt 720 tcttcaggaa ctgtgaaggt ggtggttgtg gactcggtca ctgcggtggt ttccccactt 780 ctgggaggtc agcagaggga aggcttggcc ttgatgatgc agctggcccg agagctgaag 840 accctggccc gggaccttgg catggcagtg gtggtgacca accacataac tcgagacagg 900 gacagcggga ggctcaaacc tgccctcgga cgctcctgga gctttgtgcc cagcactcgg 960 attctcctgg acaccatcga gggagcagga gcatcaggcg gccggcgcat ggcgtgtctg 1020 gccaaatctt cccgacagcc aacaggtttc caggagatgg tagacattgg gacctggggg 1080 acctcagagc agagtgccac attacagggt gatcagacat gacctgtgct gttgtttggg 1140 aaacagggaa gcattgggga cccctcccaa cttttcttcc cagtaacgcc tgctgtttac 1200 tgccacctgg cactggtgac tacagacgtt ctcaggctgg ccagaagaga catcttgggt 1260 tccttggcct cactctctgt aagcatataa accacaggcg aaagaggatg ctgcattgcg 1320 aggacccaga aattcatact ggtgccacgt ttccttccct tatttctaac gtgtatgttt 1380 ctggtggaaa ccaagttcac cctggctggg agcatctctg atgaggcatg ctggcgactg 1440 gatggataat cctgtgcatc accattgtgt cctgtgctcc ctcctagcgc agtggccaag 1500 ccgggaaagc ctctaacttg caaaaaaaaa aaaaaaaaaa a 1541 <210> 544 <211> 2368 <212> DNA <213> Homo sapiens <400> 544 gggaatcccg gcggatcccg ggcgggcgga tgacccccag ccctaccctt ggtgccgcct 60 cctcctctct cctttctcct ccggcagcca gcgcgcctgt gtcctctcta ggaaggggta 120 ggggaggggc gtctggagag gaccccccgc gaatgcccac gtgacgtgca gtccccctgg 180 ggctgttccg gcctgcgggg aacatgggcg tgctcagggt cggactgtgc cctggcctta 240 ccgaggagat gatccagctt ctcaggagcc acaggatcaa gacagtggtg gacctggttt 300 ctgcagacct ggaagaggta gctcagaaat gtggcttgtc ttacaaggcc ctggttgccc 360 tgaggcgggt gctgctggct cagttctcgg ctttccccgt gaatggcgct gatctctacg 420 aggaactgaa gacctccact gccatcctgt ccactggcat tggcagtctt gataaactgc 480 ttgatgctgg tctctatact ggagaagtga ctgaaattgt aggaggccca ggtagcggca 540 aaactcaggt atgtctctgt atggcagcaa atgtggccca tggcctgcag caaaacgtcc 600 tatatgtaga ttccaatgga gggctgacag cttcccgcct cctccagctg cttcaggcta 660 aaacccagga tgaggaggaa caggcagaag ctctccggag gatccaggtg gtgcatgcat 720 ttgacatctt ccagatgctg gatgtgctgc aggagctccg aggcactgtg gcccagcagg 780 tgactggttc ttcaggaact gtgaaggtgg tggttgtgga ctcggtcact gcggtggttt 840 ccccacttct gggaggtcag cagagggaag gcttggcctt gatgatgcag ctggcccgag 900 agctgaagac cctggcccgg gaccttggca tggcagtggt ggtgaccaac cacataactc 960 gagacaggga cagcgggagg ctcaaacctg ccctcggacg ctcctggagc tttgtgccca 1020 gcactcggat tctcctggac accatcgagg gagcaggagc atcaggcggc cggcgcatgg 1080 cgtgtctggc caaatcttcc cgacagccaa caggtttcca ggagatggta gacattggga 1140 cctgggggac ctcagagcag agtgccacat tacagggtga tcagacatga cctgtgctgt 1200 tgtttgggaa acagggaagc attggggacc cctcccaact tttcttccca gtaacgcctg 1260 ctgtttactg ccacctggca ctggtgacta cagacgttct caggctggcc agaagagaca 1320 tcttgggttc cttggcctca ctctctgtaa gcatataaac cacaggcgaa agaggatgct 1380 gcattgcgag gacccagaaa ttcatactgg tgccacgttt ccttccctta tttctaacgt 1440 gtatgtttct ggtggaaacc aagttcaccc tggctgggag catctctgat gaggcatgct 1500 ggcgactgga tggataatcc tgtgcatcac cattgtgtcc tgtgctccct cctagcgcag 1560 tggccaagcc gggaaagcct ctaacttgcc tttgctgctg ctgccttttt tttcttttgt 1620 ctctgccttt ccatttgtta gatgggggcc cactcttcct tagctctgtc tctgagttac 1680 tgggtggaaa taagcttata aatgaaatac tcttcttcat ctctgttttg ctcttaaaaa 1740 tataaaaagg caattccccg agccctagag ccacctgatt tccccttaga aggctgtttt 1800 tcagtttccc cccagtgagg cccaaagaac agtttattcc tcctttcctc ttgctgattt 1860 ggtttcagac ctgcctgcat caccatgact aggtgagaac gtgtgggctc gctgcagttc 1920 cagggatgta atttaacaga aagggagggt atgacctgct cctggtgaat ccagccactc 1980 atttaatatg catggtgccc tgtggggccc ctccacagta cagcataacc agaggtgctg 2040 aaccatggcc ttgcccataa acagacagag gagaatttgc acagtaaata gagccagctg 2100 ggaaaattga tgctgacgta aataatacat ggcaaatcta gtcctttatg cagaaattca 2160 ttgctggtgg ctccaagatg caatataatt acacctctct tcctgccagc tgtaccacag 2220 ctagtgccct agtgtatgaa ataatccctc tgtctttcac cagcactgtg gccatccgtc 2280 tgagagccat gaccctggct gggaggggac gaagacacca gggaatggaa aataaaagga 2340 aaagtacaga aaaaaaaaaa aaaaaaaa 2368 <210> 545 <211> 1663 <212> DNA <213> Homo sapiens <400> 545 tgtgtcctct ctaggaaggg gtaggggagg ggcgtctgga gaggaccccc cgcgaatgcc 60 cacgtgacgt gcagtccccc tggggctgtt ccggcctgcg gggaacatgg gcgtgctcag 120 ggtcggactg tgccctggcc ttaccgagga gatgatccag cttctcagga gccacaggat 180 caagacagtg gtggacctgg tttctgcaga cctggaagag gtagctcaga aatgtggctt 240 gtcttacaag gccctggttg ccctgaggcg ggtgctgctg gctcagttct cggctttccc 300 cgtgaatggc gctgatctct acgaggaact gaagacctcc actgccatcc tgtccactgg 360 cattggcagt cttgataaac tgcttgatgc tggtctctat actggagaag tgactgaaat 420 tgtaggaggc ccaggtagcg gcaaaactca ggtatgtctc tgtatggcag caaatgtggc 480 ccatggcctg cagcaaaacg tcctatatgt agattccaat ggagggctga cagcttcccg 540 cctcctccag ctgcttcagg ctaaaaccca ggatgaggag gaacaggcag aagctctcca 600 gaggatccag gtggtgcatg catttgacat cttccagatg ctggatgtgc tgcaggagct 660 ccgaggcact gtggcccagc aggtgactgg ttcttcagga actgtgaagg tggtggttgt 720 ggactcggtc actgcggtgg tttccccact tctgggaggt cagcagaggg aaggcttggc 780 cttgatgatg cagctggccc gagagctgaa gaccctggcc cgggaccttg gcatggcagt 840 ggtggtgacc aaccacataa ctcgagacag ggacagcggg aggctcaaac ctgccctcgg 900 acgctcctgg agctttgtgc ccagcactcg gattctcctg gacaccatcg agggagcagg 960 agcatcaggc ggccggcgca tggcgtgtct ggccaaatct tcccgacagc caacaggttt 1020 ccaggagatg gtagacattg ggacctgggg gacctcagag cagagtgcca cattacaggg 1080 tgatcagaca tgacctgtgc tgttgtttgg gaaacaggga agcattgggg acccctccca 1140 acttttcttc ccagtaacgc ctgctgttta ctgccacctg gcactggtga ctacagacgt 1200 tctcaggctg gccagaagag acatcttggg ttccttggcc tcactctctg taagcatata 1260 aaccacaggc gaaagaggat gctgcattgc gaggacccag aaattcatac tggtgccacg 1320 tttccttccc ttatttctaa cgtgtatgtt tctggtggaa accaagttca ccctggctgg 1380 gagcatctct gatgaggcat gctggcgact ggatggataa tcctgtgcat caccattgtg 1440 tcctgtgctc cctcctagcg cagtggccaa gccgggaaag cctctaactt gcctttgctg 1500 ctgctgcctt ttttttcttt tgtctctgcc tttccatttg ttagatgggg gcccactctt 1560 ccttagctct gtctctgagt tactgggtgg aaataagctt ataaatgaaa tactcttctt 1620 catctctgtt ttgctcttaa aaatataaaa aggcaattcc ccg 1663 <210> 546 <211> 1694 <212> DNA <213> Homo sapiens <400> 546 ctggaacccg gaagcggcag cgcggcgcga cccggcgggc gggctctggg cgcgggaatc 60 ccggcggatc ccgggcgggc ggatgacccc cagccctacc cttggtgccg cctcctcctc 120 tctcctttct cctccggcag ccagcgcgcc tgtgtcctct ctaggaaggg gtaggggagg 180 ggcgtctgga gaggaccccc cgcgaatgcc cacgtgacgt gcagtccccc tggggctgtt 240 ccggcctgcg gggaacatgg gcgtgctcag ggtcggactg tgccctggcc ttaccgagga 300 gatgatccag cttctcagga gccacaggat caagacagtg gtggacctgg tttctgcaga 360 cctggaagag gtagctcaga aatgtggctt gtcttacaag tcttgataaa ctgcttgatg 420 ctggtctcta tactggagaa gtgactgaaa ttgtaggagg cccaggtagc ggcaaaactc 480 aggtatgtct ctgtatggca gcaaatgtgg cccatggcct gcagcaaaac gtcctatatg 540 tagattccaa tggagggctg acagcttccc gcctcctcca gctgcttcag gctaaaaccc 600 aggatgagga ggaacaggca gaagctctcc ggaggatcca ggtggtgcat gcatttgaca 660 tcttccagat gctggatgtg ctgcaggagc tccgaggcac tgtggcccag caggtgactg 720 gttcttcagg aactgtgaag gtggtggttg tggactcggt cactgcggtg gtttccccac 780 ttctgggagg tcagcagagg gaaggcttgg ccttgatgat gcagctggcc cgagagctga 840 agaccctggc ccgggacctt ggcatggcag tggtggtgac caaccacata actcgagaca 900 gggacagcgg gaggctcaaa cctgccctcg gacgctcctg gagctttgtg cccagcactc 960 ggattctcct ggacaccatc gagggagcag gagcatcagg cggccggcgc atggcgtgtc 1020 tggccaaatc ttcccgacag ccaacaggtt tccaggagat ggtagacatt gggacctggg 1080 ggacctcaga gcagagtgcc acattacagg gtgatcagac atgacctgtg ctgttgtttg 1140 ggaaacaggg aagcattggg gacccctccc aacttttctt cccagtaacg cctgctgttt 1200 actgccacct ggcactggtg actacagacg ttctcaggct ggccagaaga gacatcttgg 1260 gttccttggc ctcactctct gtaagcatat aaaccacagg cgaaagagga tgctgcattg 1320 cgaggaccca gaaattcata ctggtgccac gtttccttcc cttatttcta acgtgtatgt 1380 ttctggtgga aaccaagttc accctggctg ggagcatctc tgatgaggca tgctggcgac 1440 tggatggata atcctgtgca tcaccattgt gtcctgtgct ccctcctagc gcagtggcca 1500 agccgggaaa gcctctaact tgcctttgct gctgctgcct tttttttctt ttgtctctgc 1560 ctttccattt gttagatggg ggcccactct tccttagctc tgtctctgag ttactgggtg 1620 gaaataagct tataaatgaa atactcttct tcatctctgt tttgctctta aaaatataaa 1680 aaggcaattc cccg 1694 <210> 547 <211> 1544 <212> DNA <213> Homo sapiens <400> 547 tgtgtcctct ctaggaaggg gtaggggagg ggcgtctgga gaggaccccc cgcgaatgcc 60 cacgtgacgt gcagtccccc tggggctgtt ccggcctgcg gggaacatgg gcgtgctcag 120 ggtcggactg tgccctggcc ttaccgagga gatgatccag cttctcagga gccacaggat 180 caagacagtg gtggacctgg tttctgcaga cctggaagag gtagctcaga aatgtggctt 240 gtcttacaag tcttgataaa ctgcttgatg ctggtctcta tactggagaa gtgactgaaa 300 ttgtaggagg cccaggtagc ggcaaaactc aggtatgtct ctgtatggca gcaaatgtgg 360 cccatggcct gcagcaaaac gtcctatatg tagattccaa tggagggctg acagcttccc 420 gcctcctcca gctgcttcag gctaaaaccc aggatgagga ggaacaggca gaagctctcc 480 ggaggatcca ggtggtgcat gcatttgaca tcttccagat gctggatgtg ctgcaggagc 540 tccgaggcac tgtggcccag caggtgactg gttcttcagg aactgtgaag gtggtggttg 600 tggactcggt cactgcggtg gtttccccac ttctgggagg tcagcagagg gaaggcttgg 660 ccttgatgat gcagctggcc cgagagctga agaccctggc ccgggacctt ggcatggcag 720 tggtggtgac caaccacata actcgagaca gggacagcgg gaggctcaaa cctgccctcg 780 gacgctcctg gagctttgtg cccagcactc ggattctcct ggacaccatc gagggagcag 840 gagcatcagg cggccggcgc atggcgtgtc tggccaaatc ttcccgacag ccaacaggtt 900 tccaggagat ggtagacatt gggacctggg ggacctcaga gcagagtgcc acattacagg 960 gtgatcagac atgacctgtg ctgttgtttg ggaaacaggg aagcattggg gacccctccc 1020 aacttttctt cccagtaacg cctgctgttt actgccacct ggcactggtg actacagacg 1080 ttctcaggct ggccagaaga gacatcttgg gttccttggc ctcactctct gtaagcatat 1140 aaaccacagg cgaaagagga tgctgcattg cgaggaccca gaaattcata ctggtgccac 1200 gtttccttcc cttatttcta acgtgtatgt ttctggtgga aaccaagttc accctggctg 1260 ggagcatctc tgatgaggca tgctggcgac tggatggata atcctgtgca tcaccattgt 1320 gtcctgtgct ccctcctagc gcagtggcca agccgggaaa gcctctaact tgcctttgct 1380 gctgctgcct tttttttctt ttgtctctgc ctttccattt gttagatggg ggcccactct 1440 tccttagctc tgtctctgag ttactgggtg gaaataagct tataaatgaa atactcttct 1500 tcatctctgt tttgctctta aaaatataaa aaggcaattc cccg 1544 <210> 548 <211> 1598 <212> DNA <213> Homo sapiens <220> <221> misc_feature <222> (270)..(271) <223> "n" means any of A, T, G, and C. <400> 548 attcggcacg agcgcgcctg tgtcctctct aggaaggggt aggggagggg cgtctggaga 60 ggaccccccg cgaatgccca cgtgacgtgc agtccccctg gggctgttcc ggcctgcggg 120 gaacatgggc gtgctcaggg tcggactgtg ccctggcctt accgaggaga tgatccagct 180 tctcaggagc cacaggatca agacagtggt ggacctggtt tctgcagacc tggaagaggt 240 agctcagaaa tgtggcttgt cttacaagtn ncttgataaa ctgcttgatg ctggtctcta 300 tactggagaa gtgactgaaa ttgtaggagg cccaggtagc ggcaaaactc aggtatgtct 360 ctgtatggca gcaaatgtgg cccatggcct gcagcaaaac gtcctatatg tagattccaa 420 tggagggctg acagcttccc gcctcctcca gctgcttcag gctaaaaccc aggatgagga 480 ggaacaggca gaagctctcc ggaggatcca ggtggtgcat gcatttgaca tcttccagat 540 gctggatgtg ctgcaggagc tccgaggcac tgtggcccag caggtgactg gttcttcagg 600 aactgtgaag gtggtggttg tggactcggt cactgcggtg gtttccccac ttctgggagg 660 tcagcagagg gaaggcttgg ccttgatgat gcagctggcc cgagagctga agaccctggc 720 ccgggacctt ggcatggcag tggtggtgac caaccacata actcgagaca gggacagcgg 780 gaggctcaaa cctgccctcg gacgctcctg gagctttgtg cccagcactc ggattctcct 840 ggacaccatc gagggagcag gagcatcagg cggccggcgc atggcgtgtc tggccaaatc 900 ttcccgacag ccaacaggtt tccaggagat ggtagacatt gggacctggg ggacctcaga 960 gcagagtgcc acattacagg gtgatcagac atgacctgtg ctgttgtttg ggaaacaggg 1020 aagcattggg gacccctccc aacttttctt cccagtaacg cctgctgttt actgccacct 1080 ggcactggtg actacagacg ttctcaggct ggccagaaga gacatcttgg gttccttggc 1140 ctcactctct gtaagcatat aaaccacagg cgaaagagga tgctgcattg cgaggaccca 1200 gaaattcata ctggtgccac gtttccttcc cttatttcta acgtgtatgt ttctggtgga 1260 aaccaagttc accctggctg ggagcatctc tgatgaggca tgctggcgac tggatggata 1320 atcctgtgca tcaccattgt gtcctgtgct ccctcctagc gcagtggcca agccgggaaa 1380 gcctctaact tgcctttgct gctgctgcct tttttttctt ttgtctctgc ctttccattt 1440 gttagatggg ggcccactct tccttagctc tgtctctgag ttactgggtg gaaataagct 1500 tataaatgaa atactcttct tcatctctgt tttgctctta aaaatataaa aaggcaattc 1560 cccgaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa 1598 <210> 549 <211> 1226 <212> DNA <213> Homo sapiens <400> 549 gtcctctcta ggaaggggta ggggaggggc gtctggagag gaccccccgc gaatgcccac 60 gtgacgtgca gtccccctgg ggctgttccg gcctgcgggg aacatgggcg tgctcagggt 120 cggactgtgc cctggcctta ccgaggagat gatccagctt ctcaggagcc acaggatcaa 180 gacagtggtg gacctggttt ctgcagacct ggaagaggta gctcagaaat gtggcttgtc 240 ttacaaggcc ctggttgccc tgaggcgggt gctgctggct cagttctcgg ctttccccgt 300 gaatggcgct gatctctacg aggaactgaa gacctccact gccatcctgt ccactggcat 360 tggcaggtat gtctctgtat ggcagcaaat gtggcccatg gcctgcagca aaacgtccta 420 tatgtagatt ccaatggagg gctgacagct tcccgcctcc tccagctgct tcaggctaaa 480 acccaggatg aggaggaaca ggcagaagct ctccggagga tccaggtggt gcatgcattt 540 gacatcttcc agatgctgga tgtgctgcag gagctccgag gcactgtggc ccagcaggtg 600 actggttctt caggaactgt gaaggtggtg gttgtggact cggtcactgc ggtggtttcc 660 ccacttctgg gaggtcagca gagggaaggc ttggccttga tgatgcagct ggcccgagag 720 ctgaagaccc tggcccggga ccttggcatg gcagtggtgg tgaccaacca cataactcga 780 gacagggaca gcgggaggct caaacctgcc ctcggacgct cctggagctt tgtgcccagc 840 actcggattc tcctggacac catcgaggga gcaggagcat caggcggccg gcgcatggcg 900 tgtctggcca aatcttcccg acagccaaca ggtttccagg agatggtaga cattgggacc 960 tgggggacct cagagcagag tgccacatta cagggtgatc agacatgacc tgtgctgttg 1020 tttgggaaac agggaagcat tggggacccc tcccaacttt tcttcccagt aacgcctgct 1080 gtttactgcc acctggcact ggtgactaca gacgttctca ggctggccag aagagacatc 1140 ttgggttcct tggcctcact ctctgtaagc atataaacca caggcgaaag aggaaaaaaa 1200 aaaaaaaaaa aaaaaaaaaa aaaaaa 1226 <210> 550 <211> 1767 <212> DNA <213> Homo sapiens <400> 550 ctggaacccg gaagcggcag cgcggcgcga cccggcgggc gggctctggg cgcgggaatc 60 ccggcggatc ccgggcgggc ggatgacccc cagccctacc cttggtgccg cctcctcctc 120 tctcctttct cctccggcag ccagcgcgcc tgtgtcctct ctaggaaggg gtaggggagg 180 ggcgtctgga gaggaccccc cgcgaatgcc cacgtgacgt gcagtccccc tggggctgtt 240 ccggcctgcg gggaacatgg gcgtgctcag ggtcggactg tgccctggcc ttaccgagga 300 gatgatccag cttctcagga gccacaggat caagacagtg gtggacctgg tttctgcaga 360 cctggaagag gtagctcaga aatgtggctt gtcttacaag gccctggttg ccctgaggcg 420 ggtgctgctg gctcagttct cggctttccc cgtgaatggc gctgatctcc acgaggaact 480 gaagacctct actgccatcc tgtccactgg cattggcagg tatgtctctg tatggcagca 540 aatgtggccc atggcctgca gcaaaacgtc ctatatgtag attccaatgg agggctgaca 600 gcttcccgcc tcctccagct gcttcaggct aaaacccagg atgaggagga acaggcagaa 660 gctctccgga ggatccaggt ggtgcatgca tttgacatct tccagatgct ggatgtgctg 720 caggagctcc gaggcactgt ggcccagcag gtgactggtt cttcaggaac tgtgaaggtg 780 gtggttgtgg actcggtcac tgcggtggtt tccccacttc tgggaggtca gcagagggaa 840 ggcttggcct tgatgatgca gctggcccga gagctgaaga ccctggcccg ggaccttggc 900 atggcagtgg tggtgaccaa ccacataact cgagacaggg acagcgggag gctcaaacct 960 gccctcggac gctcctggag ctttgtgccc agcactcgga ttctcctgga caccatcgag 1020 ggagcaggag catcaggcgg ccggcgcatg gcgtgtctgg ccaaatcttc ccgacagcca 1080 acaggtttcc aggagatggt agacattggg acctggggga cctcagagca gagtgccaca 1140 ttacagggtg atcagacatg acctgtgctg ttgtttggga aacagggaag cattggggac 1200 ccctcccaac ttttcttccc agtaacgcct gctgtttact gccacctggc actggtgact 1260 acagacgttc tcaggctggc cagaagagac atcttgggtt ccttggcctc actctctgta 1320 agcatataaa ccacaggcga aagaggatgc tgcattgcga ggacccagaa attcatactg 1380 gtgccacgtt tccttccctt atttctaacg tgtatgtttc tggtggaaac caagttcacc 1440 ctggctggga gcatctctga tgaggcatgc tggcgactgg atggataatc ctgtgcatca 1500 ccattgtgtc ctgtgctccc tcctagcgca gtggccaagc cgggaaagcc tctaacttgc 1560 ctttgctgct gctgcctttt ttttcttttg tctctgcctt tccatttgtt agatgggggc 1620 ccactcttcc ttagctctgt ctctgagtta ctgggtggaa ataagcttat aaatgaaata 1680 ctcttcttca tctctgtttt gctcttaaaa atataaaaag gcaattcccc gaaaaaaaaa 1740 aaaaaaaaaa aaaaaaaaaa aaaaaaa 1767 <210> 551 <211> 1699 <212> DNA <213> Homo sapiens <400> 551 aggatgagga ggaacaggca gaagctctcc ggaggatcca ggtggtgcat gcatttgaca 60 tcttccagat gctggatgtg ctgcaggagc tccgaggcac tgtggcccag caggtgactg 120 gttcttcagg aactgtgaag gtggtggttg tggactcggt cactgcggtg gtttccccac 180 ttctgggagg tcagcagagg gaaggcttgg ccttgatgat gcagctggtc cgagagctga 240 agaccctggc ccgggacctt ggcatggcag tggtggtgac caaccacata actcgagaca 300 gggacagcgg gaggctcaaa cctgccctcg gacgctcctg gagctttgtg cccagcactc 360 ggattctcct ggacaccatc gagggagcag gagcatcagg cggccggcgc atggcgtgtc 420 tggccaaatc ttcccgacag ccaacaggtt tccaggagat ggtagacatt gggacctggg 480 ggacctcaga gcagagtgcc acattacagg gtgatcagac atgacctgtg ctgttgtttg 540 ggaaacaggg aagcattggg gacccctccc aacttttctt cccagtaacg cctgctgttt 600 actgccacct ggcactggtg actacagacg ttctcaggct ggccagaaga gacatcttgg 660 gttccttggc ctcactctct gtaagcatat aaaccacagg cgaaagagga tgctgcattg 720 cgaggaccca gaaattcata ctggtgccac gtttccttcc cttatttcta acgtgtatgt 780 ttctggtgga aaccaagttc accctggctg ggagcatctc tgatgaggca tgctggcgac 840 tggatggata atcctgtgca tcaccattgt gtcctgtgct ccctcctagc gcagtggcca 900 agccgggaaa gcctctaact tgcctttgct gctgctgcct tttttttctt ttgtctctgc 960 ctttccattt gttagatggg ggcccactct tccttagctc tgtctctgag ttactgggtg 1020 gaaataagct tataaatgaa atactcttct tcatctctgt tttgctctta aaaatataaa 1080 aaggcaattc cccgagccct agagccacct gatttcccct tagaaggctg tttttcagtt 1140 tcccccagtg aggcccaaag aacagtttat tcctcctttc ctcttgctga tttggtttca 1200 gacctgcctg catcaccatg actaggtgag aacgtgtggg ctcgctgcag ttccagggat 1260 ataatttaac agaaagggag ggtatgacct gctcctggtg aatccagcca ctcatttaat 1320 atgcatggtg ccctgtgggg cccctccaca gtacagcata accagaggtg ctgaaccatg 1380 gccttgccca taaacagaca gaggagaatt tgcacagtaa atagagccag ctgggaaaat 1440 tgatgctgac gtaaataata catggcaaat ctagtccttt atgcagaaat tcattgctgg 1500 tggctccaag atgcaatata attacacctc tcttcctgcc agctgtacca cagctagtgc 1560 cctagtgtat gaaataatcc ctctgtcttt caccagcact gtggccatcc gtctgagagc 1620 catgaccctg gctgggaggg gacgaagaca ccagggaatg gaaaataaaa ggaaaagtac 1680 agaaaaaaaa aaaaaaaaa 1699 <210> 552 <211> 1559 <212> DNA <213> Homo sapiens <400> 552 ctggaacccg gaagcggcag cgcggcgcga cccggcgggc gggctctggg cgcgggaatc 60 ccggcggatc ccgggcgggc ggatgacccc cagccctacc cttggtgccg cctcctcctc 120 tctcctttct cctccggcag ccagcgcgcc tgtgtcctct ctaggaaggg gtaggggagg 180 ggcgtctgga gaggaccccc cgcgaatgcc cacgtgacgt gcagtccccc tggggctgtt 240 ccggcctgcg gggaacatgg gcgtgctcag ggtcggactg tgccctggcc ttaccgagga 300 gatgatccag cttctcagga gccacaggat caagacagtg gtggacctgg tttctgcaga 360 cctggaagag gtagctcaga aatgtggctt gtcttacaag tcttgataaa ctgcttgatg 420 ctggtctcta tactggagaa gtgactgaaa ttgtaggagg cccaggtagc ggcaaaactc 480 aggcagaagc tctccggagg atccaggtgg tgcatgcatt tgacatcttc cagatgctgg 540 atgtgctgca ggagctccga ggcactgtgg cccagcaggt gactggttct tcaggaactg 600 tgaaggtggt ggttgtggac tcggtcactg cggtggtttc cccacttctg ggaggtcagc 660 agagggaagg cttggccttg atgatgcagc tggcccgaga gctgaagacc ctggcccggg 720 accttggcat ggcagtggtg gtgaccaacc acataactcg agacagggac agcgggaggc 780 tcaaacctgc cctcggacgc tcctggagct ttgtgcccag cactcggatt ctcctggaca 840 ccatcgaggg agcaggagca tcaggcggcc ggcgcatggc gtgtctggcc aaatcttccc 900 gacagccaac aggtttccag gagatggtag acattgggac ctgggggacc tcagagcaga 960 gtgccacatt acagggtgat cagacatgac ctgtgctgtt gtttgggaaa cagggaagca 1020 ttggggaccc ctcccaactt ttcttcccag taacgcctgc tgtttactgc cacctggcac 1080 tggtgactac agacgttctc aggctggcca gaagagacat cttgggttcc ttggcctcac 1140 tctctgtaag catataaacc acaggcgaaa gaggatgctg cattgcgagg acccagaaat 1200 tcatactggt gccacgtttc cttcccttat ttctaacgtg tatgtttctg gtggaaacca 1260 agttcaccct ggctgggagc atctctgatg aggcatgctg gcgactggat ggataatcct 1320 gtgcatcacc attgtgtcct gtgctccctc ctagcgcagt ggccaagccg ggaaagcctc 1380 taacttgcct ttgctgctgc tgcctttttt ttcttttgtc tctgcctttc catttgttag 1440 atgggggccc actcttcctt agctctgtct ctgagttact gggtggaaat aagcttataa 1500 atgaaatact cttcttcatc tctgttttgc tcttaaaaat ataaaaaggc aattccccg 1559 <210> 553 <211> 1409 <212> DNA <213> Homo sapiens <400> 553 tgtgtcctct ctaggaaggg gtaggggagg ggcgtctgga gaggaccccc cgcgaatgcc 60 cacgtgacgt gcagtccccc tggggctgtt ccggcctgcg gggaacatgg gcgtgctcag 120 ggtcggactg tgccctggcc ttaccgagga gatgatccag cttctcagga gccacaggat 180 caagacagtg gtggacctgg tttctgcaga cctggaagag gtagctcaga aatgtggctt 240 gtcttacaag tcttgataaa ctgcttgatg ctggtctcta tactggagaa gtgactgaaa 300 ttgtaggagg cccaggtagc ggcaaaactc aggcagaagc tctccggagg atccaggtgg 360 tgcatgcatt tgacatcttc cagatgctgg atgtgctgca ggagctccga ggcactgtgg 420 cccagcaggt gactggttct tcaggaactg tgaaggtggt ggttgtggac tcggtcactg 480 cggtggtttc cccacttctg ggaggtcagc agagggaagg cttggccttg atgatgcagc 540 tggcccgaga gctgaagacc ctggcccggg accttggcat ggcagtggtg gtgaccaacc 600 acataactcg agacagggac agcgggaggc tcaaacctgc cctcggacgc tcctggagct 660 ttgtgcccag cactcggatt ctcctggaca ccatcgaggg agcaggagca tcaggcggcc 720 ggcgcatggc gtgtctggcc aaatcttccc gacagccaac aggtttccag gagatggtag 780 acattgggac ctgggggacc tcagagcaga gtgccacatt acagggtgat cagacatgac 840 ctgtgctgtt gtttgggaaa cagggaagca ttggggaccc ctcccaactt ttcttcccag 900 taacgcctgc tgtttactgc cacctggcac tggtgactac agacgttctc aggctggcca 960 gaagagacat cttgggttcc ttggcctcac tctctgtaag catataaacc acaggcgaaa 1020 gaggatgctg cattgcgagg acccagaaat tcatactggt gccacgtttc cttcccttat 1080 ttctaacgtg tatgtttctg gtggaaacca agttcaccct ggctgggagc atctctgatg 1140 aggcatgctg gcgactggat ggataatcct gtgcatcacc attgtgtcct gtgctccctc 1200 ctagcgcagt ggccaagccg ggaaagcctc taacttgcct ttgctgctgc tgcctttttt 1260 ttcttttgtc tctgcctttc catttgttag atgggggccc actcttcctt agctctgtct 1320 ctgagttact gggtggaaat aagcttataa atgaaatact cttcttcatc tctgttttgc 1380 tcttaaaaat ataaaaaggc aattccccg 1409 <210> 554 <211> 1477 <212> DNA <213> Homo sapiens <400> 554 ctggaacccg gaagcggcag cgcggcgcga cccggcgggc gggctctggg cgcgggaatc 60 ccggcggatc ccgggcgggc ggatgacccc cagccctacc cttggtgccg cctcctcctc 120 tctcctttct cctccggcag ccagcgcgcc tgtgtcctct ctaggaaggg gtaggggagg 180 ggcgtctgga gaggaccccc cgcgaatgcc cacgtgacgt gcagtccccc tggggctgtt 240 ccggcctgcg gggaacatgg gcgtgctcag ggtcggactg tgccctggcc ttaccgagga 300 gatgatccag cttctcagga gccacaggat caagacagtg gtggacctgg tttctgcaga 360 cctggaagag gtagctcaga aatgtggctt gtcttacaag gcagaagctc tccggaggat 420 ccaggtggtg catgcatttg acatcttcca gatgctggat gtgctgcagg agctccgagg 480 cactgtggcc cagcaggtga ctggttcttc aggaactgtg aaggtggtgg ttgtggactc 540 ggtcactgcg gtggtttccc cacttctggg aggtcagcag agggaaggct tggccttgat 600 gatgcagctg gcccgagagc tgaagaccct ggcccgggac cttggcatgg cagtggtggt 660 gaccaaccac ataactcgag acagggacag cgggaggctc aaacctgccc tcggacgctc 720 ctggagcttt gtgcccagca ctcggattct cctggacacc atcgagggag caggagcatc 780 aggcggccgg cgcatggcgt gtctggccaa atcttcccga cagccaacag gtttccagga 840 gatggtagac attgggacct gggggacctc agagcagagt gccacattac agggtgatca 900 gacatgacct gtgctgttgt ttgggaaaca gggaagcatt ggggacccct cccaactttt 960 cttcccagta acgcctgctg tttactgcca cctggcactg gtgactacag acgttctcag 1020 gctggccaga agagacatct tgggttcctt ggcctcactc tctgtaagca tataaaccac 1080 aggcgaaaga ggatgctgca ttgcgaggac ccagaaattc atactggtgc cacgtttcct 1140 tcccttattt ctaacgtgta tgtttctggt ggaaaccaag ttcaccctgg ctgggagcat 1200 ctctgatgag gcatgctggc gactggatgg ataatcctgt gcatcaccat tgtgtcctgt 1260 gctccctcct agcgcagtgg ccaagccggg aaagcctcta acttgccttt gctgctgctg 1320 cctttttttt cttttgtctc tgcctttcca tttgttagat gggggcccac tcttccttag 1380 ctctgtctct gagttactgg gtggaaataa gcttataaat gaaatactct tcttcatctc 1440 tgttttgctc ttaaaaatat aaaaaggcaa ttccccg 1477 <210> 555 <211> 1327 <212> DNA <213> Homo sapiens <400> 555 tgtgtcctct ctaggaaggg gtaggggagg ggcgtctgga gaggaccccc cgcgaatgcc 60 cacgtgacgt gcagtccccc tggggctgtt ccggcctgcg gggaacatgg gcgtgctcag 120 ggtcggactg tgccctggcc ttaccgagga gatgatccag cttctcagga gccacaggat 180 caagacagtg gtggacctgg tttctgcaga cctggaagag gtagctcaga aatgtggctt 240 gtcttacaag gcagaagctc tccggaggat ccaggtggtg catgcatttg acatcttcca 300 gatgctggat gtgctgcagg agctccgagg cactgtggcc cagcaggtga ctggttcttc 360 aggaactgtg aaggtggtgg ttgtggactc ggtcactgcg gtggtttccc cacttctggg 420 aggtcagcag agggaaggct tggccttgat gatgcagctg gcccgagagc tgaagaccct 480 ggcccgggac cttggcatgg cagtggtggt gaccaaccac ataactcgag acagggacag 540 cgggaggctc aaacctgccc tcggacgctc ctggagcttt gtgcccagca ctcggattct 600 cctggacacc atcgagggag caggagcatc aggcggccgg cgcatggcgt gtctggccaa 660 atcttcccga cagccaacag gtttccagga gatggtagac attgggacct gggggacctc 720 agagcagagt gccacattac agggtgatca gacatgacct gtgctgttgt ttgggaaaca 780 gggaagcatt ggggacccct cccaactttt cttcccagta acgcctgctg tttactgcca 840 cctggcactg gtgactacag acgttctcag gctggccaga agagacatct tgggttcctt 900 ggcctcactc tctgtaagca tataaaccac aggcgaaaga ggatgctgca ttgcgaggac 960 ccagaaattc atactggtgc cacgtttcct tcccttattt ctaacgtgta tgtttctggt 1020 ggaaaccaag ttcaccctgg ctgggagcat ctctgatgag gcatgctggc gactggatgg 1080 ataatcctgt gcatcaccat tgtgtcctgt gctccctcct agcgcagtgg ccaagccggg 1140 aaagcctcta acttgccttt gctgctgctg cctttttttt cttttgtctc tgcctttcca 1200 tttgttagat gggggcccac tcttccttag ctctgtctct gagttactgg gtggaaataa 1260 gcttataaat gaaatactct tcttcatctc tgttttgctc ttaaaaatat aaaaaggcaa 1320 ttccccg 1327 <210> 556 <211> 1638 <212> DNA <213> Homo sapiens <400> 556 atgtggctgg ccagaccaag ggccagtgtg actgtgaagc agcatcatga gaggggtaaa 60 accaaggaac agactgcatg agcccttggg ccccttccag ctctaatact ccatggtgat 120 ggcagccctg cccttctctg aagatctcaa aatgcctgac acctgtgtcc ttccgcactg 180 ccctgggaag gagaataagg atggcagaag ctctccggag gatccaggtg gtgcatgcat 240 ttgacatctt ccagatgctg gatgtgctgc aggagctccg aggcactgtg gcccagcagg 300 tgactggttc ttcaggaact gtgaaggtgg tggttgtgga ctcggtcact gcggtggttt 360 ccccacttct gggaggtcag cagagggaag gcttggcctt gatgatgcag ctggcccgag 420 agctgaagac cctggcccgg gaccttggca tggcagtggt ggtgaccaac cacataactc 480 gagacaggga cagcgggagg ctcaaacctg ccctcggacg ctcctggagc tttgtgccca 540 gcactcggat tctcctggac accatcgagg gagcaggagc atcaggcggc cggcgcatgg 600 cgtgtctggc caaatcttcc cgacagtcta ttgactcaga ggacagcttt gtcccaggcc 660 gaagggcctc tctgtctgac ctgactgacc tggaggacat tgaaggcctg acagtgcggc 720 agctgaaaga gatcttggct cgcaactttg tcaactacaa gggctgctgt gagaagtggg 780 agctgatgga gagagtgacc cggctataca aggatcagaa aggactccag cacctggggg 840 gagcagtacc atcaggcttg gaggagaacc tgtgtaagat ctgcatggac tcacccattg 900 actgtgttct tctggagtgt ggccacatgg taacctgtac caagtgtggc aagcgcatga 960 atgaatgtcc catctgccgg cagtatgtaa tccgagctgt gcatgtcttc cggtcctgag 1020 agcttgcatc ggtttcttca gtgccttaca gggaaatagc ctggggtgtc tgggctcagg 1080 gttggccagc ttgcagagga gcaagctagt agaaatattg cagggttccc aaaaccaggt 1140 caagcaagat gccatgtcac ccctgagcat gcctgtcttc ccaggggtgt acctcttggc 1200 tggcaaagcc caaggccagt gggaacttgt ataaatcaca tgggtatgtt cttggttcag 1260 tgatcttgga gtgatgatgg taactgatga acagagaact ttccagaact tgggtcctgt 1320 cttcctccct gaacctagac agtttcaccc ctcctcctgt acccaaccca tccccacccc 1380 atatgggaga tgcttgccca tgtgtttcat caatcagaag tcctcctccc cagcacattc 1440 ggatttaaat ttctggtctc tccggctttc tgtgctttaa ctatctttgc taaagtctct 1500 tgctacattg cctaaatcca tttgtttctt tggaccaaaa atgttagttt accagaccga 1560 tagtggtcct taggacagat tttagaccag taaacttatc tttggtgaga aatgaaatac 1620 aaatgctata gaaaaatt 1638 <210> 557 <211> 620 <212> DNA <213> Homo sapiens <400> 557 tccggaggat ccaggtggtg catgcatttg acatcttcca gatgctggat gtgctgcagg 60 agctccgagg cactgtggcc cagcaggatg gaattcccga gcacctaaat cacatacctc 120 attgtttaca tgttcatctt ccctgctgaa cagtaaagcc ccctgagtgg aaggatcatg 180 tcatatttat gtctgcattc cccactaggt gactggttct tcaggaactg tgaaggtggt 240 ggttgtggac tcggtcactg cggtggtttc cccacttctg ggaggtcagc agagggaagg 300 cttggccttg atgatgcagc tggcccgaga gctgaagacc ctggcccggg accttggcat 360 ggcagtggtg gtgaccaacc acataactcg agacagggac agcgggaggc tcaaacctgc 420 cctcggacgc tcctggagct ttgtgcccag cactcggatt ctcctggaca ccatcgaggg 480 agcaggagca tcaggcggcc ggcgcatggc gtgtctggcc aaatcttccc gacagccaac 540 aggtttccag gagatggtag acattgggac ctgggggacc tcagagcaga gtgccacatt 600 acagggtgat cagacatgac 620 <210> 558 <211> 603 <212> DNA <213> Homo sapiens <400> 558 ctgcagacct ggaagaggta gctcagaaat gtggcttgtc ttacaaggcc ctggttgccc 60 tgaggcgggt gctgctggct cagttctcgg ctttccccgt gaatggcgct gatctctacg 120 aggaactgaa gacctccact gccatcctgt ccactggcat tggcagacat ggagggcgca 180 ctcaagtggg aacctgggag gactgcagct gcctcaggtc cccgcaggga gatcgtggag 240 tggggtcagg aatgctctga agaaggcagg acttgggcat ggaggaacag atggactttc 300 gctgaatgct ttcgatgaac gaggcactgc ggtcagcact tcacgtcttg ataaactgct 360 tgatgctggt ctctatactg gagaagtgac tgaaattgta ggaggcccag gtagcggcaa 420 aactcaggta tgtctctgta tggcagcaaa tgtggcccat ggcctgcagc aaaacgtcct 480 atatgtagat tccaatggag ggctgacagc ttcccgcctc ctccagctgc ttcaggctaa 540 aacccaggat gaggaggaac aggcagaagc tctccggagg atccaggtgg tgcatgcatt 600 tga 603 <210> 559 <211> 289 <212> DNA <213> Homo sapiens <400> 559 ctgcagacct ggaagaggta gctcagaaat gtggcttgtc ttacaaggcc ctggttgccc 60 tgaggcgggt gctgctggct cagttctcgg ctttccccgt gaatggcgct gatctctacg 120 aggaactgaa gacctccact gccatcctgt ccactggcat tggcagtctt gataaactgc 180 ttgatgctgg tctctatact ggagaagtga ctgaaattgt aggaggccca ggtagcggca 240 aaactcaggc agaagctctc cggaggatcc aggtggtgca tgcatttga 289 <210> 560 <211> 386 <212> DNA <213> Homo sapiens <400> 560 ctgcagacct ggaagaggta gctcagaaat gtggcttgtc ttacaaggcc ctggttgccc 60 tgaggcgggt gctgctggct cagttctcgg ctttccccgt gaatggcgct gatctctacg 120 aggaactgaa gacctccact gccatcctgt ccactggcat tggcagacat ggagggcgca 180 ctcaagtggg aacctgggag gactgcagct gcctcaggtc cccgcaggga gatcgtggag 240 tggggtcagg aatgctctga agaaggcagg acttgggcat ggaggaacag atggactttc 300 gctgaatgct ttcgatgaac gaggcactgc ggtcagcact tcacggcaga agctctccgg 360 aggatccagg tggtgcatgc atttga 386 <210> 561 <211> 207 <212> DNA <213> Homo sapiens <400> 561 ctgcagacct ggaagaggta gctcagaaat gtggcttgtc ttacaaggcc ctggttgccc 60 tgaggcgggt gctgctggct cagttctcgg ctttccccgt gaatggcgct gatctctacg 120 aggaactgaa gacctccact gccatcctgt ccactggcat tggcaggcag aagctctccg 180 gaggatccag gtggtgcatg catttga 207 <210> 562 <211> 1576 <212> DNA <213> Homo sapiens <400> 562 gttggtgaat ggcgttggtg gcgggaaagt tgagtctctc ctgcgccgag ccttcggggc 60 gatgtgtagt gccttccata gggctgagtc tgggaccgag ctccttgccc gacttgaagg 120 tagaagttcc ttgaaagaaa tagaaccaaa tctgtttgct gatgaagatt cacctgtgca 180 tggtgatatt cttgaatttc atggcccaga aggaacagga aaaacagaaa tgctttatca 240 cctaacagca cgatgtatac ttcccaaatc agaaggtggc ctggaagtag aagtcttatt 300 tattgataca gattaccact ttgatatgct ccggctagtt acaattcttg agcacagact 360 atcccaaagc tctgaagaaa taatcaaata ctgcctggga agattttttt tggtgtactg 420 cagtagtagc acccacttac ttcttacact ttactcacta gaaagtatgt tttgtagtca 480 cccatctctc tgccttttga ttttggatag cctgtcagct ttttactgga tagaccgcgt 540 caatggagga gaaagtgtga acttacagga gtctactctg aggaaatgtt ctcagtgctt 600 agagaagctt gtaaatgact atcgcctggt tctttttgca acgacacaaa ctataatgca 660 gaaagcctcg agctcatcag aagaaccttc tcatgcctct cgacgactgt gtgatgtgga 720 catagactac agaccttatc tctgtaaggc atggcagcaa ctggtgaagc acaggatgtt 780 tttctccaaa caagatgatt ctcaaagcag caaccaattt tcattagttt cacgttgttt 840 aaaaagtaac agtttaaaaa aacatttttt tattattgga gaaagtgggg ttgaattttg 900 ttgatataca tcataaaata gtcttttgca gggtactacg caagccttaa aatttttctt 960 aagacagagt cttgctctgt ctcccaggct ggagtgcagt ggcacaatca tggctcactg 1020 cagccttgaa ctcctggcct caagggatcc tcctatgtgt gcctcctaga gtgcagggat 1080 tacaggcgtg agccactgct cgtggccaaa agttttcttt tttttttttt ctttttgaaa 1140 cagtcttact ctgtctccca ggctgctgga gtgcagtggc acaatctcgg cccgctgcag 1200 cctctgcctc ttgggttcaa gtgattcttc cacctcagcc tcccaggtag ctgggattac 1260 aggcacccac caccacgcct ggctaatttt tgtattttta atagagacgg ggtttcacca 1320 tgttggccag gctggtctcg aactcctgac ctcaagtgat ccacccacct cggcctccca 1380 aagtgctagg attacaggcc cgtgcccagc cctaaagttt taaactctag gggaattaac 1440 agtatttctt tacagaatgg atttgttaaa ctagcacagt aaaagtaaag actattctgt 1500 ttctaggctg ttgaatcaaa gtgattttag caattaaact ttgtattaat ttaaaaaaaa 1560 aaaaaaaaaa aaaaaa 1576 <210> 563 <211> 3094 <212> DNA <213> Homo sapiens <400> 563 tttgactggc cgtagagtct gcgcagttgg tgaatggcgt tggtggcggg aaagttgagt 60 ctctcctgcg ccgagccttc ggggcgatgt gtagtgcctt ccatagggct gagtctggga 120 ccgagctcct tgcccgactt gaaggtagaa gttccttgaa agaaatagaa ccaaatctgt 180 ttgctgatga agattcacct gtgcatggtg atattcttga atttcatggc ccagaaggaa 240 caggaaaaac agaaatgctt tatcacctaa cagcacgatg tatacttccc aaatcagaag 300 gtggcctgga agtagaagtc ttatttattg atacagatta ccactttgat atgctccggc 360 tagttacaat tcttgagcac agactatccc aaagctctga agaaataatc aaatactgcc 420 tgggaagatt ttttttggtg tactgcagta gtagcaccca cttacttctt acactttact 480 cactagaaag tatgttttgt agtcacccat ctctctgcct tttgattttg gatagcctgt 540 cagcttttta ctggatagac cgcgtcaatg gaggagaaag tgtgaactta caggagtcta 600 ctctgaggaa atgttctcag tgcttagaga agcttgtaaa tgactatcgc ctggttcttt 660 ttgcaacgac acaaactata atgcagaaag cctcgagctc atcagaagaa ccttctcatg 720 cctctcgacg actgtgtgat gtggacatag actacagacc ttatctctgt aaggcatggc 780 agcaactggt gaagcacagg atgtttttct ccaaacaaga tgattctcaa agcagcaacc 840 aattttcatt agtttcacgt tgtttaaaaa gtaacagttt aaaaaaacat ttttttatta 900 ttggagaaag tggggttgaa ttttgttgat atacatcata aaatagtctt ttgcagggta 960 ctacgcaagc cttaaaattt ttcttaagac agagtcttgc tctgtctccc aggctggagt 1020 gcagtggcac aatcatggct cactgcagcc ttgaactcct ggcctcaagg gatcctccta 1080 tgtgtgcctc ctagagtgca gggattacag gcgtgagcca ctgctcgtgg ccaaaagttt 1140 tctttttttt tttttttctt tttgaaacag tcttactctg tctcccaggc tgctggagtg 1200 cagtggcaca atctcggccc gctgcagcct ctgcctcttg ggttcaagtg attcttccac 1260 ctcagcctcc caggtagctg ggattacagg cacccaccac cacgcctggc taatttttgt 1320 atttttaata gagacggggt ttcaccatgt tggccaggct ggtctcgaac tcctgacctc 1380 aagtgatcca cccacctcgg cctcccaaag tgctaggatt acaggcccgt gcccagccct 1440 aaagttttaa actctagggg aattaacagt atttctttac agaatggatt tgttaaacta 1500 gcacagtaaa agtaaagact attctgtttc taggctgttg aatcaaagtg attttagcaa 1560 ttaaactttg tattaattta ccaccaatat ttcttcacaa aggaactttt aaaagattat 1620 ctcagaaagt aaatctgaga ggtaagaagt aataatgagt aaatggtaag tacttgagta 1680 aatctaaaga aatattgata gtaaggcaat cctaagcaaa aagaacaaag ctggaggcat 1740 cacgctaccc agcttcaaac tatactacaa ggctacagta accaaaacag catagtactg 1800 gcacaaaaac acacgtagac tgatggaaca gaatagagaa tttagaaatg agaccacaca 1860 cctataattt ttttgatctt cgatgaacct gacaaaaaca agcaatgggc aatggattct 1920 ctattcaata aatcgtgctg ggataactgg ccagccatat ggaaaagatt gaaaatggac 1980 gccttcctta tgccatatac aaaaattaac tcaagatgga ttaaagactt aatgtaaaac 2040 ccaaaacagt aaaaatcctg gaagacaacc caggcagtac cattcaggac ataggcacag 2100 gcaaagattt catgacgaag acgccaaaaa caattgcaac agaagcaaaa attcacaaat 2160 gggatctaat taaactaaag agctgcacag caaaagaaac tatcaagaga gtaaacagac 2220 agcttacaga atgggagaaa attgttgcaa actatgcatc tgagaaaggt ctgaaatcca 2280 gcatctatac gtaatttaaa caaatttaga agaaaaaacc accccattaa aaagtgggca 2340 aaggacatga acagacactt ttcaaaagaa gacatctgtg gccaacaatc ctatggaaaa 2400 aagcccagca tcactgatca ttagagaaat gcaaatcgaa acaacaacga gataccatct 2460 cacaccagtc caaatggcta ttataaaaat gtcagaaaat aacagatgct ggtgaggttg 2520 tggagaaaaa gatatgctta tacactgttg gtggaaatgt aaattaaatt agttcagcca 2580 ttgtggaaga cagtgtgggg ataaagacag agataccatt caacccagca atctcattac 2640 tgggtatata cccaaaggaa tagaaatcat tgttataaag acacatgcac gcgtatgttc 2700 gttgcagcac tgcccatcag tgacagactg gattaaaaaa atgtggtaca tacacaccag 2760 ggaatactat acagccataa aaaggaacaa gactgactgg gcgtggtggc tcatgcctgt 2820 gatcctagca ctttgcgagg ccgaggtggg tggattgccc gcgctcagga ggtcaagacc 2880 agcctgggca acacggtgaa accccatctc tattaaaata caaaaaatta gctgggcatg 2940 gtggtgcgtg cctgtagtgc cagctactca ggaggccgag gcaggagaat tgctggaacc 3000 caggaggtgg aggttgcagt gagctgagat cgcgccattg cactcccgcc tgggcgactc 3060 catctctaaa aaaaaaaaaa aaaaaaaaaa aaaa 3094 <210> 564 <211> 3094 <212> DNA <213> Homo sapiens <400> 564 tttgactggc cgtagagtct gcgcagttgg tgaatggcgt tggtggcggg aaagttgagt 60 ctctcctgcg ccgagccttc ggggcgatgt gtagtgcctt ccatagggct gagtctggga 120 ccgagctcct tgcccgactt gaaggtagaa gttccttgaa agaaatagaa ccaaatctgt 180 ttgctgatga agattcacct gtgcatggtg atattcttga atttcatggc ccagaaggaa 240 caggaaaaac agaaatgctt tatcacctaa cagcacgatg tatacttccc aaatcagaag 300 gtggcctgga agtagaagtc ttatttattg atacagatta ccactttgat atgctccggc 360 tagttacaat tcttgagcac agactatccc aaagctctga agaaataatc aaatactgcc 420 tgggaagatt ttttttggtg tactgcagta gtagcaccca cttacttctt acactttact 480 cactagaaag tatgttttgt agtcacccat ctctctgcct tttgattttg gatagcctgt 540 cagcttttta ctggatagac cgcgtcaatg gaggagaaag tgtgaactta caggagtcta 600 ctctgaggaa atgttctcag tgcttagaga agcttgtaaa tgactatcgc ctggttcttt 660 ttgcaacgac acaaactata atgcagaaag cctcgagctc atcagaagaa ccttctcatg 720 cctctcgacg actgtgtgat gtggacatag actacagacc ttatctctgt aaggcatggc 780 agcaactggt gaagcacagg atgtttttct ccaaacaaga tgattctcaa agcagcaacc 840 aattttcatt agtttcacgt tgtttaaaaa gtaacagttt aaaaaaacat ttttttatta 900 ttggagaaag tggggttgaa ttttgttgat atacatcata aaatagtctt ttgcagggta 960 ctacgcaagc cttaaaattt ttcttaagac agagtcttgc tctgtctccc aggctggagt 1020 gcagtggcac aatcatggct cactgcagcc ttgaactcct ggcctcaagg gatcctccta 1080 tgtgtgcctc ctagagtgca gggattacag gcgtgagcca ctgctcgtgg ccaaaagttt 1140 tctttttttt tttttttctt tttgaaacag tcttactctg tctcccaggc tgctggagtg 1200 cagtggcaca atctcggccc gctgcagcct ctgcctcttg ggttcaagtg attcttccac 1260 ctcagcctcc caggtagctg ggattacagg cacccaccac cacgcctggc taatttttgt 1320 atttttaata gagacggggt ttcaccatgt tggccaggct ggtctcgaac tcctgacctc 1380 aagtgatcca cccacctcgg cctcccaaag tgctaggatt acaggcccgt gcccagccct 1440 aaagttttaa actctagggg aattaacagt atttctttac agaatggatt tgttaaacta 1500 gcacagtaaa agtaaagact attctgtttc taggctgttg aatcaaagtg attttagcaa 1560 ttaaactttg tattaattta ccaccaatat ttcttcacaa aggaactttt aaaagattat 1620 ctcagaaagt aaatctgaga ggtaagaagt aataatgagt aaatggtaag tacttgagta 1680 aatctaaaga aatattgata gtaaggcaat cctaagcaaa aagaacaaag ctggaggcat 1740 cacgctaccc agcttcaaac tatactacaa ggctacagta accaaaacag catagtactg 1800 gcacaaaaac acacgtagac tgatggaaca gaatagagaa tttagaaatg agaccacaca 1860 cctataattt ttttgatctt cgatgaacct gacaaaaaca agcaatgggc aatggattct 1920 ctattcaata aatcgtgctg ggataactgg ccagccatat ggaaaagatt gaaaatggac 1980 gccttcctta tgccatatac aaaaattaac tcaagatgga ttaaagactt aatgtaaaac 2040 ccaaaacagt aaaaatcctg gaagacaacc caggcagtac cattcaggac ataggcacag 2100 gcaaagattt catgacgaag acgccaaaaa caattgcaac agaagcaaaa attcacaaat 2160 gggatctaat taaactaaag agctgcacag caaaagaaac tatcaagaga gtaaacagac 2220 agcttacaga atgggagaaa attgttgcaa actatgcatc tgagaaaggt ctgaaatcca 2280 gcatctatac gtaatttaaa caaatttaga agaaaaaacc accccattaa aaagtgggca 2340 aaggacatga acagacactt ttcaaaagaa gacatctgtg gccaacaatc ctatggaaaa 2400 aagcccagca tcactgatca ttagagaaat gcaaatcgaa acaacaacga gataccatct 2460 cacaccagtc caaatggcta ttataaaaat gtcagaaaat aacagatgct ggtgaggttg 2520 tggagaaaaa gatatgctta tacactgttg gtggaaatgt aaattaaatt agttcagcca 2580 ttgtggaaga cagtgtgggg ataaagacag agataccatt caacccagca atctcattac 2640 tgggtatata cccaaaggaa tagaaatcat tgttataaag acacatgcac gcgtatgttc 2700 gttgcagcac tgcccatcag tgacagactg gattaaaaaa atgtggtaca tacacaccag 2760 ggaatactat acagccataa aaaggaacaa gactgactgg gcgtggtggc tcatgcctgt 2820 gatcctagca ctttgcgagg ccgaggtggg tggattgccc gcgctcagga ggtcaagacc 2880 agcctgggca acacggtgaa accccatctc tattaaaata caaaaaatta gctgggcatg 2940 gtggtgcgtg cctgtagtgc cagctactca ggaggccgag gcaggagaat tgctggaacc 3000 caggaggtgg aggttgcagt gagctgagat cgcgccattg cactcccgcc tgggcgactc 3060 catctctaaa aaaaaaaaaa aaaaaaaaaa aaaa 3094 <210> 565 <211> 1600 <212> DNA <213> Homo sapiens <400> 565 actggccgta gagtctgcgc agttggtgaa tggcgttggt ggcgggaaag ttgagtctct 60 cctgcgccga gccttcgggg cgatgtgtag tgccttccat agggctgagt ctgggaccga 120 gctccttgcc cgacttgaag gtagaagttc cttgaaagaa atagaaccaa atctgtttgc 180 tgatgaagat tcacctgtgc atggtgatat tcttgaattt catggcccag aaggaacagg 240 aaaaacagaa atgctttatc acctaacagc acgatgtata cttcccaaat cagaaggtgg 300 cctggaagta gaagtcttat ttattgatac agattaccac tttgatatgc tccggctagt 360 tacaattctt gagcacagac tatcccaaag ctctgaagaa ataatcaaat actgcctggg 420 aagatttttt ttggtgtact gcagtagtag cacccactta cttcttacac tttactcact 480 agaaagtatg ttttgtagtc acccatctct ctgccttttg attttggata gcctgtcagc 540 tttttactgg atagaccgcg tcaatggagg agaaagtgtg aacttacagg agtctactct 600 gaggaaatgt tctcagtgct tagagaagct tgtaaatgac tatcgcctgg ttctttttgc 660 aacgacacaa actataatgc agaaagcctc gagctcatca gaagaacctt ctcatgcctc 720 tcgacgactg tgtgatgtgg acatagacta cagaccttat ctctgtaagg catggcagca 780 actggtgaag cacaggatgt ttttctccaa acaagatgat tctcaaagca gcaaccaatt 840 ttcattagtt tcacgttgtt taaaaagtaa cagtttaaaa aaacattttt ttattattgg 900 agaaagtggg gttgaatttt gttgacatac atcataaaat agtcttttgc agggtactac 960 gcaagcctta aaatttttct taagacagag tcttgctctg tctcccaggc tggagtgcag 1020 tggcacaatc atggctcact gcagccttga actcctggcc tcaagggatc ctcctatgtg 1080 tgcctcctag agtgcaggga ttacaggtgt gagccactgc tcgtggccaa aagttttctt 1140 tttttttttt tttctttttg aaacagtctt actctgtctc ccaggctgct ggagtgcagt 1200 ggcacaatct cggcccgctg cagcctctgc ctcttgggtt caagtgattc ttccacctca 1260 gcctcccagg tagctgggat tacaggcacc caccaccacg cctggctaat ttttgtattt 1320 ttaatagaga cggggtttca ccatgttggc caggctggtc tcgaactcct gacctcaagt 1380 gatccaccca cctcggcctc ccaaagtgct aggattacag gcccgtgccc agccctaaag 1440 ttttaaactc taggggaatt aacagtattt ctttacagaa tggatttgtt aaactagcac 1500 agtaaaagta aagactattc tgtttctagg ctgttgaatc aaagtgattt tagcaattaa 1560 actttgtatt aatttgccac caaaaaaaaa aaaaaaaaaa 1600 <210> 566 <211> 3107 <212> DNA <213> Homo sapiens <400> 566 cggtgagtct tggcggctgt taacgcgcgc tttgggaaca ggaaggttga gagagaggtg 60 ctggggtctg cgtctatctc tgtcgctctt ttcagcccct cctggtattc ccctcctaac 120 ctgggttttt tacacgcccg cgtggcttcc tgctcgacct ccctgagtct gatcctggtt 180 tccacctcca gccctgggaa atttcctttc tccagactcg ccctccccac ccgggcctcg 240 gactttcacc ccagcttctc tctcctggcc agtgattacc cacccccaat cccaccccgc 300 cccgccgcgc aactacctcc tcccttcacc cggactggga ccatcatccc cactccactc 360 cgcccagtct gggactccac ctgcctcctc cccaatccca cactaatctc tgcttggtct 420 cttcctcttt ggcctaatct ctcgtctcgg cttattgggg acggccactc tcacagtttg 480 gttccaaaca ccagttcctg gatggattcc cgccatccat gccccctctt taattagccg 540 gtcctctcag taatgtagca gccccctcta cagattagac cctggtccta cactcttagc 600 cgctgcctgc ttttgacctt tggctcatgg gtacttgacg ttttaaactc ctaggcccag 660 gatgaggagg agcttggctc ccagccagct ggccaagaga aaacctgaag gcaggtcctg 720 tgatgatgaa gactggcaac ctggcctagt gactcctagg aaacggaaat ccagcagtga 780 gacccagatc caggagtgtt tcctgtctcc ttttcggaaa cctttgagtc agctaaccaa 840 tcaaccacct tgtctggaca gcagtcagca tgaagcattt attcgaagca ttttgtcaaa 900 gcctttcaaa gtccccattc caaattatca aggtcctctg ggctctcgag cattgggcct 960 gaaaagggct ggggtccgcc gggccctcca tgaccccctg gaaaaagatg ccttggttct 1020 gtatgagcct cccccgctga gcgctcatga ccagctgaag cttgacaagg agaaactccc 1080 tgtccatgtg gttgttgacc ctattctcag taaggttttg cggcctcatc agagagaggg 1140 agtgaaattc ctgtgggagt gtgtcaccag tcggcgcatc cctggcagcc atggctgcat 1200 catggctgat gagatgggcc taggaaagac gctgcagtgc atcacattga tgtggacact 1260 tttacgccag agtccagagt gcaagccaga aattgacaag gcagtggtgg tgtcgccttc 1320 cagcctggtg aagaactggt acaatgaggt tgggaaatgg ctcggaggga ggatccaacc 1380 tctggccatc gatggaggat ctaaggatga aatagaccaa aagctggaag gattcatgaa 1440 ccagcgtgga gccagggtgt cttctcccat cctcatcatt tcctatgaga ccttccgcct 1500 tcatgttgga gtcctccaga aaggaagtgt tggtctggtc atatgtgacg agggacacag 1560 gctcaagaac tctgagaatc agacttacca agccctggac agcttgaaca ccagccggcg 1620 ggtgctcatc tccggaactc ccatccagaa tgatctgctt gagtatttca gcttggtaca 1680 ttttgttaat tccggcatcc tagggactgc ccatgaattc aagaagcatt ttgaattgcc 1740 aattttgaag ggtcgagacg ctgctgctag tgaggcagac aggcagctag gagaggagcg 1800 gctgcgggag ctcaccagca ttgtgaatag atgcctgata cggaggactt ctgatatcct 1860 ttctaaatat ctgcctgtga agattgagca ggtcgtttgt tgtaggctga caccccttca 1920 gactgagtta tacaagaggt ttctgagaca agccaaaccg gcagaagaat tgcttgaggg 1980 caagatgagt gtgtcttccc tttcttccat cacctcgcta aagaagcttt gtaatcatcc 2040 agctctaatc tatgataagt gtgtggaaga ggaggatggc tttgtgggtg ccttggacct 2100 cttccctcct ggttacagct ctaaggccct ggagccccag ctgtcaggta agatgctggt 2160 cctggattat attctggcgg tgacccgaag ccgtagcagt gacaaagtag tgctggtgtc 2220 gaattacacc cagactttgg atctctttga gaagctgtgc cgtgcccgaa ggtacttata 2280 cgtccgcctg gatggcacga tgtccattaa gaagcgagcc aaggttgtag aacgcttcaa 2340 tagtccatcg agccctgact ttgtcttcat gctgagcagc aaagctgggg gctgtggcct 2400 caatctcatt ggggctaacc ggctggtcat gtttgaccct gactggaacc cagccaatga 2460 tgaacaagcc atggcccggg tctggcgaga tggtcaaaag aagacttgct atatctaccg 2520 cctgctgtct gcagggacca ttgaggagaa gatcttccag cgtcagagcc acaagaaggc 2580 actgagcagc tgtgtggtgg atgaggagca ggatgtagag cgccacttct ctctgggcga 2640 gttgaaggag ctgtttatcc tggatgaagc tagcctcagt gacacacatg acaggttgca 2700 ctgccgacgt tgtgtcaaca gccgtcagat ccggccaccc cctgatggtt ctgactgcac 2760 ttcagacctg gcagggtgga accactgcac tgataagtgg gggctccggg atgaggtact 2820 ccaggctgcc tgggatgctg cctccactgc tatcaccttc gtcttccacc agcattctca 2880 tgaggaacag cggggcctcc gctgataacc agctggtctg ggtgtagctc ttagaggaag 2940 gagataggga aaaggggctc cttgctccac agggccctgt tgaattttgt tctctgggag 3000 aaaatcatca agaagggctg catgatgttt gcccaaaatt tattttataa gaaaaacttt 3060 tttggttaaa aaaaagaata aaggtatgaa agggttaaaa aaaaaaa 3107 <210> 567 <211> 2607 <212> DNA <213> Homo sapiens <400> 567 gaattcgggc agattagacc ctggtcctac actcttagcc gctgcctgct tttgaccttt 60 ggctcatggg tacttgacgt tttaaactcc taggcccagg atgaggagga gcttggctcc 120 cagccagctg gccaagagaa aacctgaagg caggtcctgt gatgatgaag actggcaacc 180 tggcctagtg actcctagga aacggaaatc cagcagtgag acccagatcc aggagtgttt 240 cctgtctcct tttcggaaac ctttgagtca gctaaccaat caaccacctt gtctggacag 300 cagtcagcat gaagcattta ttcgaagcat tttgtcaaag cctttcaaag tccccattcc 360 aaattatcaa ggtcctctgg gctctcgagc attgggcctg aaaagggctg gggtccgccg 420 ggccctccat gaccccctgg aaaaagatgc cttggttctg tatgagcctc ccccgctgag 480 cgctcatgac cagctgaagc ttgacaagga gaaactccct gtccatgtgg ttgttgaccc 540 tattctcagt aaggttttgc ggcctcatca gagagaggga gtgaaattcc tgtgggagtg 600 tgtcaccagt cggcgcatcc ctggcagcca tggctgcatc atggctgatg agatgggcct 660 aggaaagacg ctgcagtgca tcacattgat gtggacactt ttacgccaga gtccagagtg 720 caagccagaa attgacaagg cagtggtggt gtcgccttcc agcctggtga agaactggta 780 caatgaggtt gggaaatggc tcggagggag gatccaacct ctggccatcg atggaggatc 840 taaggatgaa atagaccaaa agctggaagg attcatgaac cagcgtggag ccagggtgtc 900 ttctcccatc ctcatcattt cctatgagac cttccgcctt catgttggag tcctccagaa 960 aggaagtgtt ggtctggtca tatgtgacga gggacacagg ctcaagaact ctgagaatca 1020 gacttaccaa gccctggaca gcttgaacac cagccggcgg gtgctcatct ccggaactcc 1080 catccagaat gatctgcttg agtatttcag cttggtacat tttgttaatt ccggcatcct 1140 agggactgcc catgaattca agaagcattt tgaattgcca attttgaagg gtcgagacgc 1200 tgctgctagt gaggcagaca ggcagctagg agaggagcgg ctgcgggagc tcaccagcat 1260 tgtgaataga tgcctgatac ggaggacttc tgatatcctt tctaaatatc tgcctgtgaa 1320 gattgagcag gtcgtttgtt gtaggctgac accccttcag actgagttat acaagaggtt 1380 tctgagacaa gccaaaccgg cagaagaatt gcttgagggc aagatgagtg tgtcttccct 1440 ttcttccatc acctcgctaa agaagctttg taatcatcca gctctaatct atgataagtg 1500 tgtggaagag gaggatggct ttgtgggtgc cttggacctc ttccctcctg gttacagctc 1560 taaggccctg gagccccagc tgtcaggtaa gatgctggtc ctggattata ttctggcggt 1620 gacccgaagc cgtagcagtg acaaagtagt gctggtgtcg aattacaccc agactttgga 1680 tctctttgag aagctgtgcc gtgcccgaag gtacttatac gtccgcctgg atggcacgat 1740 gtccattaag aagcgagcca aggttgtaga acgcttcaat agtccatcga gccctgactt 1800 tgtcttcatg ctgagcagca aagctggggg ctgtggcctc aatctcattg gggctaaccg 1860 gctggtcatg tttgaccctg actggaaccc agccaatgat gaacaagcca tggcccgggt 1920 ctggcgagat ggtcaaaaga agacttgcta tatctaccgc ctgctgtctg cagggaccat 1980 tgaggagaag atcttccagc gtcagagcca caagaaggca ctgagcagct gtgtggtgga 2040 tgaggagcag gatgtagagc gccacttctc tctgggcgag ttgaaggagc tgtttatcct 2100 ggatgaagct agcctcagtg acacacatga caggttgcac tgccgacgtt gtgtcaacag 2160 ccgtcagatc cggccacccc ctgatggttc tgactgcact tcagacctgg cagggtggaa 2220 ccactgcact gataagtggg ggctccggga tgaggtactc caggctgcct gggatgctgc 2280 ctccactgct atcaccttcg tcttccacca gcattctcat gaggaacagc ggggcctccg 2340 ctgataacca gctggtctgg gtgtagctct tagaggaagg agatagggaa aaggggctcc 2400 ttgctccaca gggccctgtt gaattttgtt ctctgggaga aaatcatcaa gaagggctgc 2460 atgatgtttg cccaaaattt attttataag aaaaactttt ttggttaaaa aaaagaataa 2520 aggtatgaaa gggctggtga cagtcaggga tgcccccggc acacagggac taggtctagt 2580 gagaacatca ggagcagcca gggatcc 2607 <210> 568 <211> 7365 <212> DNA <213> Homo sapiens <400> 568 ggcagtttgt aggtcgcgag ggaagcgctg aggatcagga agggggcact gagtgtccgt 60 gggggaatcc tcgtgatagg aactggaata tgccttgagg gggacactat gtctttaaaa 120 acgtcggctg gtcatgaggt caggagttcc agaccagcct gaccaacgtg gtgaaactcc 180 gtctctacta aaaatacaaa aattagccgg gcgtggtgcc gctccagcta ctcaggaggc 240 tgaggcagga gaatcgctag aacccgggag gcggaggttg cagtgagccg agatcgcgcc 300 attgcactcc agcctgggcg acagagcgag actgtctcaa aacaaaacaa aacaaaacaa 360 aacaaaaaac accggctgtt cattggaaca gaaagaaatg gatttatctg ctcttcgcgt 420 tgaagaagta caaaatgtca ttaatgctat gcagaaaatc ttagagtgtc ccatctgtct 480 ggagttgatc aaggaacctg tctccacaaa gtgtgaccac atattttgca aattttgcat 540 gctgaaactt ctcaaccaga agaaagggcc ttcacagtgt cctttatgta agaatgatat 600 aaccaaaagg agcctacaag aaagtacgag atttagtcaa cttgttgaag agctattgaa 660 aatcatttgt gcttttcagc ttgacacagg tttggagtat gcaaacagct ataattttgc 720 aaaaaaggaa aataactctc ctgaacatct aaaagatgaa gtttctatca tccaaagtat 780 gggctacaga aaccgtgcca aaagacttct acagagtgaa cccgaaaatc cttccttgca 840 ggaaaccagt ctcagtgtcc aactctctaa ccttggaact gtgagaactc tgaggacaaa 900 gcagcggata caacctcaaa agacgtctgt ctacattgaa ttgggatctg attcttctga 960 agataccgtt aataaggcaa cttattgcag tgtgggagat caagaattgt tacaaatcac 1020 ccctcaagga accagggatg aaatcagttt ggattctgca aaaaaggctg cttgtgaatt 1080 ttctgagacg gatgtaacaa atactgaaca tcatcaaccc agtaataatg atttgaacac 1140 cactgagaag cgtgcagctg agaggcatcc agaaaagtat cagggtagtt ctgtttcaaa 1200 cttgcatgtg gagccatgtg gcacaaatac tcatgccagc tcattacagc atgagaacag 1260 cagtttatta ctcactaaag acagaatgaa tgtagaaaag gctgaattct gtaataaaag 1320 caaacagcct ggcttagcaa ggagccaaca taacagatgg gctggaagta aggaaacatg 1380 taatgatagg cggactccca gcacagaaaa aaaggtagat ctgaatgctg atcccctgtg 1440 tgagagaaaa gaatggaata agcagaaact gccatgctca gagaatccta gagatactga 1500 agatgttcct tggataacac taaatagcag cattcagaaa gttaatgagt ggttttccag 1560 aagtgatgaa ctgttaggtt ctgatgactc acatgatggg gagtctgaat caaatgccaa 1620 agtagctgat gtattggacg ttctaaatga ggtagatgaa tattctggtt cttcagagaa 1680 aatagactta ctggccagtg atcctcatga ggctttaata tgtaaaagtg aaagagttca 1740 ctccaaatca gtagagagta atattgaaga caaaatattt gggaaaacct atcggaagaa 1800 ggcaagcctc cccaacttaa gccatgtaac tgaaaatcta attataggag catttgttac 1860 tgagccacag ataatacaag agcgtcccct cacaaataaa ttaaagcgta aaaggagacc 1920 tacatcaggc cttcatcctg aggattttat caagaaagca gatttggcag ttcaaaagac 1980 tcctgaaatg ataaatcagg gaactaacca aacggagcag aatggtcaag tgatgaatat 2040 tactaatagt ggtcatgaga ataaaacaaa aggtgattct attcagaatg agaaaaatcc 2100 taacccaata gaatcactcg aaaaagaatc tgctttcaaa acgaaagctg aacctataag 2160 cagcagtata agcaatatgg aactcgaatt aaatatccac aattcaaaag cacctaaaaa 2220 gaataggctg aggaggaagt cttctaccag gcatattcat gcgcttgaac tagtagtcag 2280 tagaaatcta agcccaccta attgtactga attgcaaatt gatagttgtt ctagcagtga 2340 agagataaag aaaaaaaagt acaaccaaat gccagtcagg cacagcagaa acctacaact 2400 catggaaggt aaagaacctg caactggagc caagaagagt aacaagccaa atgaacagac 2460 aagtaaaaga catgacagcg atactttccc agagctgaag ttaacaaatg cacctggttc 2520 ttttactaag tgttcaaata ccagtgaact taaagaattt gtcaatccta gccttccaag 2580 agaagaaaaa gaagagaaac tagaaacagt taaagtgtct aataatgctg aagaccccaa 2640 agatctcatg ttaagtggag aaagggtttt gcaaactgaa agatctgtag agagtagcag 2700 tatttcattg gtacctggta ctgattatgg cactcaggaa agtatctcgt tactggaagt 2760 tagcactcta gggaaggcaa aaacagaacc aaataaatgt gtgagtcagt gtgcagcatt 2820 tgaaaacccc aagggactaa ttcatggttg ttccaaagat aatagaaatg acacagaagg 2880 ctttaagtat ccattgggac atgaagttaa ccacagtcgg gaaacaagca tagaaatgga 2940 agaaagtgaa cttgatgctc agtatttgca gaatacattc aaggtttcaa agcgccagtc 3000 atttgctccg ttttcaaatc caggaaatgc agaagaggaa tgtgcaacat tctctgccca 3060 ctctgggtcc ttaaagaaac aaagtccaaa agtcactttt gaatgtgaac aaaaggaaga 3120 aaatcaagga aagaatgagt ctaatatcaa gcctgtacag acagttaata tcactgcagg 3180 ctttcctgtg gttggtcaga aagataagcc agttgataat gccaaatgta gtatcaaagg 3240 aggctctagg ttttgtctat catctcagtt cagaggcaac gaaactggac tcattactcc 3300 aaataaacat ggacttttac aaaacccata tcgtatacca ccactttttc ccatcaagtc 3360 atttgttaaa actaaatgta agaaaaatct gctagaggaa aactttgagg aacattcaat 3420 gtcacctgaa agagaaatgg gaaatgagaa cattccaagt acagtgagca caattagccg 3480 taataacatt agagaaaatg tttttaaaga agccagctca agcaatatta atgaagtagg 3540 ttccagtact aatgaagtgg gctccagtat taatgaaata ggttccagtg atgaaaacat 3600 tcaagcagaa ctaggtagaa acagagggcc aaaattgaat gctatgctta gattaggggt 3660 tttgcaacct gaggtctata aacaaagtct tcctggaagt aattgtaagc atcctgaaat 3720 aaaaaagcaa gaatatgaag aagtagttca gactgttaat acagatttct ctccatatct 3780 gatttcagat aacttagaac agcctatggg aagtagtcat gcatctcagg tttgttctga 3840 gacacctgat gacctgttag atgatggtga aataaaggaa gatactagtt ttgctgaaaa 3900 tgacattaag gaaagttctg ctgtttttag caaaagcgtc cagaaaggag agcttagcag 3960 gagtcctagc cctttcaccc atacacattt ggctcagggt taccgaagag gggccaagaa 4020 attagagtcc tcagaagaga acttatctag tgaggatgaa gagcttccct gcttccaaca 4080 cttgttattt ggtaaagtaa acaatatacc ttctcagtct actaggcata gcaccgttgc 4140 taccgagtgt ctgtctaaga acacagagga gaatttatta tcattgaaga atagcttaaa 4200 tgactgcagt aaccaggtaa tattggcaaa ggcatctcag gaacatcacc ttagtgagga 4260 aacaaaatgt tctgctagct tgttttcttc acagtgcagt gaattggaag acttgactgc 4320 aaatacaaac acccaggatc ctttcttgat tggttcttcc aaacaaatga ggcatcagtc 4380 tgaaagccag ggagttggtc tgagtgacaa ggaattggtt tcagatgatg aagaaagagg 4440 aacgggcttg gaagaaaata atcaagaaga gcaaagcatg gattcaaact taggtgaagc 4500 agcatctggg tgtgagagtg aaacaagcgt ctctgaagac tgctcagggc tatcctctca 4560 gagtgacatt ttaaccactc agcagaggga taccatgcaa cataacctga taaagctcca 4620 gcaggaaatg gctgaactag aagctgtgtt agaacagcat gggagccagc cttctaacag 4680 ctacccttcc atcataagtg actcttctgc ccttgaggac ctgcgaaatc cagaacaaag 4740 cacatcagaa aaagcagtat taacttcaca gaaaagtagt gaatacccta taagccagaa 4800 tccagaaggc ctttctgctg acaagtttga ggtgtctgca gatagttcta ccagtaaaaa 4860 taaagaacca ggagtggaaa ggtcatcccc ttctaaatgc ccatcattag atgataggtg 4920 gtacatgcac agttgctctg ggagtcttca gaatagaaac tacccatctc aagaggagct 4980 cattaaggtt gttgatgtgg aggagcaaca gctggaagag tctgggccac acgatttgac 5040 ggaaacatct tacttgccaa ggcaagatct agagggaacc ccttacctgg aatctggaat 5100 cagcctcttc tctgatgacc ctgaatctga tccttctgaa gacagagccc cagagtcagc 5160 tcgtgttggc aacataccat cttcaacctc tgcattgaaa gttccccaat tgaaagttgc 5220 agaatctgcc cagagtccag ctgctgctca tactactgat actgctgggt ataatgcaat 5280 ggaagaaagt gtgagcaggg agaagccaga attgacagct tcaacagaaa gggtcaacaa 5340 aagaatgtcc atggtggtgt ctggcctgac cccagaagaa tttatgctcg tgtacaagtt 5400 tgccagaaaa caccacatca ctttaactaa tctaattact gaagagacta ctcatgttgt 5460 tatgaaaaca gatgctgagt ttgtgtgtga acggacactg aaatattttc taggaattgc 5520 gggaggaaaa tgggtagtta gctatttctg ggtgacccag tctattaaag aaagaaaaat 5580 gctgaatgag catgattttg aagtcagagg agatgtggtc aatggaagaa accaccaagg 5640 tccaaagcga gcaagagaat cccaggacag aaagatcttc agggggctag aaatctgttg 5700 ctatgggccc ttcaccaaca tgcccacaga tcaactggaa tggatggtac agctgtgtgg 5760 tgcttctgtg gtgaaggagc tttcatcatt cacccttggc acaggtgtcc acccaattgt 5820 ggttgtgcag ccagatgcct ggacagagga caatggcttc catgcaattg ggcagatgtg 5880 tgaggcacct gtggtgaccc gagagtgggt gttggacagt gtagcactct accagtgcca 5940 ggagctggac acctacctga taccccagat cccccacagc cactactgac tgcagccagc 6000 cacaggtaca gagccacagg accccaagaa tgagcttaca aagtggcctt tccaggccct 6060 gggagctcct ctcactcttc agtccttcta ctgtcctggc tactaaatat tttatgtaca 6120 tcagcctgaa aaggacttct ggctatgcaa gggtccctta aagattttct gcttgaagtc 6180 tcccttggaa atctgccatg agcacaaaat tatggtaatt tttcacctga gaagatttta 6240 aaaccattta aacgccacca attgagcaag atgctgattc attatttatc agccctattc 6300 tttctattca ggctgttgtt ggcttagggc tggaagcaca gagtggcttg gcctcaagag 6360 aatagctggt ttccctaagt ttacttctct aaaaccctgt gttcacaaag gcagagagtc 6420 agacccttca atggaaggag agtgcttggg atcgattatg tgacttaaag tcagaatagt 6480 ccttgggcag ttctcaaatg ttggagtgga acattgggga ggaaattctg aggcaggtat 6540 tagaaatgaa aaggaaactt gaaacctggg catggtggct cacgcctgta atcccagcac 6600 tttgggaggc caaggtgggc agatcactgg aggtcaggag ttcgaaacca gcctggccaa 6660 catggtgaaa ccccatctct actaaaaata cagaaattag ccggtcatgg tggtggacac 6720 ctgtaatccc agctactcag gtggctaagg caggagaatc acttcagccc gggaggtgga 6780 ggttgcagtg agccaagatc ataccacggc actccagcct gggtgacagt gagactgtgg 6840 ctcaaaaaaa aaaaaaaaaa aggaaaatga aactaggaaa ggtttcttaa agtctgagat 6900 atatttgcta gatttctaaa gaatgtgttc taaaacagca gaagattttc aagaaccggt 6960 ttccaaagac agtcttctaa ttcctcatta gtaataagta aaatgtttat tgttgtagct 7020 ctggtatata atccattcct cttaaaatat aagacctctg gcatgaatat ttcatatcta 7080 taaaatgaca gatcccacca ggaaggaagc tgttgctttc tttgaggtga tttttttcct 7140 ttgctccctg ttgctgaaac catacagctt cataaataat tttgcttgct gaaggaagaa 7200 aaagtgtttt tcataaaccc attatccagg actgtttata gctgttggaa ggactaggtc 7260 ttccctagcc cccccagtgt gcaagggcag tgaagacttg attgtacaaa atacgttttg 7320 taaatgttgt gctgttaaca ctgcaaataa acttggtagc aaaca 7365 <210> 569 <211> 7102 <212> DNA <213> Homo sapiens <400> 569 aaaactgcga ctgcgcggcg tgagctcgct gagacttcct ggaccccgca ccaggctgtg 60 gggtttctca gataactggg cccctgcgct caggaggcct tcaccctctg ctctggttca 120 ttggaacaga aagaaatgga tttatctgct cttcgcgttg aagaagtaca aaatgtcatt 180 aatgctatgc agaaaatctt agagtgtccc atctgtctgg agttgatcaa ggaacctgtc 240 tccacaaagt gtgaccacat attttgcaaa ttttgcatgc tgaaacttct caaccagaag 300 aaagggcctt cacagtgtcc tttatgtaag aatgatataa ccaaaaggag cctacaagaa 360 agtacgagat ttagtcaact tgttgaagag ctattgaaaa tcatttgtgc ttttcagctt 420 gacacaggtt tggagtatgc aaacagctat aattttgcaa aaaaggaaaa taactctcct 480 gaacatctaa aagatgaagt ttctatcatc caaagtatgg gctacagaaa ccgtgccaaa 540 agacttctac agagtgaacc cgaaaatcct tccttgcagg aaaccagtct cagtgtccaa 600 ctctctaacc ttggaactgt gagaactctg aggacaaagc agcggataca acctcaaaag 660 acgtctgtct acattgaatt gggatctgat tcttctgaag ataccgttaa taaggcaact 720 tattgcagtg tgggagatca agaattgtta caaatcaccc ctcaaggaac cagggatgaa 780 atcagtttgg attctgcaaa aaaggctgct tgtgaatttt ctgagacgga tgtaacaaat 840 actgaacatc atcaacccag taataatgat ttgaacacca ctgagaagcg tgcagctgag 900 aggcatccag aaaagtatca gggtagttct gtttcaaact tgcatgtgga gccatgtggc 960 acaaatactc atgccagctc attacagcat gagaacagca gtttattact cactaaagac 1020 agaatgaatg tagaaaaggc tgaattctgt aataaaagca aacagcctgg cttagcaagg 1080 agccaacata acagatgggc tggaagtaag gaaacatgta atgataggcg gactcccagc 1140 acagaaaaaa aggtagatct gaatgctgat cccctgtgtg agagaaaaga atggaataag 1200 cagaaactgc catgctcaga gaatcctaga gatactgaag atgttccttg gataacacta 1260 aatagcagca ttcagaaagt taatgagtgg ttttccagaa gtgatgaact gttaggttct 1320 gatgactcac atgatgggga gtctgaatca aatgccaaag tagctgatgt attggacgtt 1380 ctaaatgagg tagatgaata ttctggttct tcagagaaaa tagacttact ggccagtgat 1440 cctcatgagg ctttaatatg taaaagtgaa agagttcact ccaaatcagt agagagtaat 1500 attgaagaca aaatatttgg gaaaacctat cggaagaagg caagcctccc caacttaagc 1560 catgtaactg aaaatctaat tataggagca tttgttactg agccacagat aatacaagag 1620 cgtcccctca caaataaatt aaagcgtaaa aggagaccta catcaggcct tcatcctgag 1680 gattttatca agaaagcaga tttggcagtt caaaagactc ctgaaatgat aaatcaggga 1740 actaaccaaa cggagcagaa tggtcaagtg atgaatatta ctaatagtgg tcatgagaat 1800 aaaacaaaag gtgattctat tcagaatgag aaaaatccta acccaataga atcactcgaa 1860 aaagaatctg ctttcaaaac gaaagctgaa cctataagca gcagtataag caatatggaa 1920 ctcgaattaa atatccacaa ttcaaaagca cctaaaaaga ataggctgag gaggaagtct 1980 tctaccaggc atattcatgc gcttgaacta gtagtcagta gaaatctaag cccacctaat 2040 tgtactgaat tgcaaattga tagttgttct agcagtgaag agataaagaa aaaaaagtac 2100 aaccaaatgc cagtcaggca cagcagaaac ctacaactca tggaaggtaa agaacctgca 2160 actggagcca agaagagtaa caagccaaat gaacagacaa gtaaaagaca tgacagcgat 2220 actttcccag agctgaagtt aacaaatgca cctggttctt ttactaagtg ttcaaatacc 2280 agtgaactta aagaatttgt caatcctagc cttccaagag aagaaaaaga agagaaacta 2340 gaaacagtta aagtgtctaa taatgctgaa gaccccaaag atctcatgtt aagtggagaa 2400 agggttttgc aaactgaaag atctgtagag agtagcagta tttcattggt acctggtact 2460 gattatggca ctcaggaaag tatctcgtta ctggaagtta gcactctagg gaaggcaaaa 2520 acagaaccaa ataaatgtgt gagtcagtgt gcagcatttg aaaaccccaa gggactaatt 2580 catggttgtt ccaaagataa tagaaatgac acagaaggct ttaagtatcc attgggacat 2640 gaagttaacc acagtcggga aacaagcata gaaatggaag aaagtgaact tgatgctcag 2700 tatttgcaga atacattcaa ggtttcaaag cgccagtcat ttgctccgtt ttcaaatcca 2760 ggaaatgcag aagaggaatg tgcaacattc tctgcccact ctgggtcctt aaagaaacaa 2820 agtccaaaag tcacttttga atgtgaacaa aaggaagaaa atcaaggaaa gaatgagtct 2880 aatatcaagc ctgtacagac agttaatatc actgcaggct ttcctgtggt tggtcagaaa 2940 gataagccag ttgataatgc caaatgtagt atcaaaggag gctctaggtt ttgtctatca 3000 tctcagttca gaggcaacga aactggactc attactccaa ataaacatgg acttttacaa 3060 aacccatatc gtataccacc actttttccc atcaagtcat ttgttaaaac taaatgtaag 3120 aaaaatctgc tagaggaaaa ctttgaggaa cattcaatgt cacctgaaag agaaatggga 3180 aatgagaaca ttccaagtac agtgagcaca attagccgta ataacattag agaaaatgtt 3240 tttaaagaag ccagctcaag caatattaat gaagtaggtt ccagtactaa tgaagtgggc 3300 tccagtatta atgaaatagg ttccagtgat gaaaacattc aagcagaact aggtagaaac 3360 agagggccaa aattgaatgc tatgcttaga ttaggggttt tgcaacctga ggtctataaa 3420 caaagtcttc ctggaagtaa ttgtaagcat cctgaaataa aaaagcaaga atatgaagaa 3480 gtagttcaga ctgttaatac agatttctct ccatatctga tttcagataa cttagaacag 3540 cctatgggaa gtagtcatgc atctcaggtt tgttctgaga cacctgatga cctgttagat 3600 gatggtgaaa taaaggaaga tactagtttt gctgaaaatg acattaagga aagttctgct 3660 gtttttagca aaagcgtcca gaaaggagag cttagcagga gtcctagccc tttcacccat 3720 acacatttgg ctcagggtta ccgaagaggg gccaagaaat tagagtcctc agaagagaac 3780 ttatctagtg aggatgaaga gcttccctgc ttccaacact tgttatttgg taaagtaaac 3840 aatatacctt ctcagtctac taggcatagc accgttgcta ccgagtgtct gtctaagaac 3900 acagaggaga atttattatc attgaagaat agcttaaatg actgcagtaa ccaggtaata 3960 ttggcaaagg catctcagga acatcacctt agtgaggaaa caaaatgttc tgctagcttg 4020 ttttcttcac agtgcagtga attggaagac ttgactgcaa atacaaacac ccaggatcct 4080 ttcttgattg gttcttccaa acaaatgagg catcagtctg aaagccaggg agttggtctg 4140 agtgacaagg aattggtttc agatgatgaa gaaagaggaa cgggcttgga agaaaataat 4200 caagaagagc aaagcatgga ttcaaactta ggtgaagcag catctgggtg tgagagtgaa 4260 acaagcgtct ctgaagactg ctcagggcta tcctctcaga gtgacatttt aaccactcag 4320 cagagggata ccatgcaaca taacctgata aagctccagc aggaaatggc tgaactagaa 4380 gctgtgttag aacagcatgg gagccagcct tctaacagct acccttccat cataagtgac 4440 tcttctgccc ttgaggacct gcgaaatcca gaacaaagca catcagaaaa agcagtatta 4500 acttcacaga aaagtagtga ataccctata agccagaatc cagaaggcct ttctgctgac 4560 aagtttgagg tgtctgcaga tagttctacc agtaaaaata aagaaccagg agtggaaagg 4620 tcatcccctt ctaaatgccc atcattagat gataggtggt acatgcacag ttgctctggg 4680 agtcttcaga atagaaacta cccatctcaa gaggagctca ttaaggttgt tgatgtggag 4740 gagcaacagc tggaagagtc tgggccacac gatttgacgg aaacatctta cttgccaagg 4800 caagatctag agggaacccc ttacctggaa tctggaatca gcctcttctc tgatgaccct 4860 gaatctgatc cttctgaaga cagagcccca gagtcagctc gtgttggcaa cataccatct 4920 tcaacctctg cattgaaagt tccccaattg aaagttgcag aatctgccca gagtccagct 4980 gctgctcata ctactgatac tgctgggtat aatgcaatgg aagaaagtgt gagcagggag 5040 aagccagaat tgacagcttc aacagaaagg gtcaacaaaa gaatgtccat ggtggtgtct 5100 ggcctgaccc cagaagaatt tatgctcgtg tacaagtttg ccagaaaaca ccacatcact 5160 ttaactaatc taattactga agagactact catgttgtta tgaaaacaga tgctgagttt 5220 gtgtgtgaac ggacactgaa atattttcta ggaattgcgg gaggaaaatg ggtagttagc 5280 tatttctggg tgacccagtc tattaaagaa agaaaaatgc tgaatgagca tgattttgaa 5340 gtcagaggag atgtggtcaa tggaagaaac caccaaggtc caaagcgagc aagagaatcc 5400 caggacagaa agatcttcag ggggctagaa atctgttgct atgggccctt caccaacatg 5460 cccacagatc aactggaatg gatggtacag ctgtgtggtg cttctgtggt gaaggagctt 5520 tcatcattca cccttggcac aggtgtccac ccaattgtgg ttgtgcagcc agatgcctgg 5580 acagaggaca atggcttcca tgcaattggg cagatgtgtg aggcacctgt ggtgacccga 5640 gagtgggtgt tggacagtgt agcactctac cagtgccagg agctggacac ctacctgata 5700 ccccagatcc cccacagcca ctactgactg cagccagcca caggtacagg ccacaggacc 5760 ccaagaatga gcttacaaag tggcctttcc aggccctggg agctcctctc actcttcagt 5820 ccttctactg tcctggctac taaatatttt atgtacatca gcctgaaaag gacttctggc 5880 tatgcaaggg tcccttaaag attttctgct tgaagtctcc cttggaaatc tgccatgagc 5940 acaaaattat ggtaattttt cacctgagaa gattttaaaa ccatttaaac gccaccaatt 6000 gagcaagatg ctgattcatt atttatcagc cctattcttt ctattcaggc tgttgttggc 6060 ttagggctgg aagcacagag tggcttggcc tcaagagaat agctggtttc cctaagttta 6120 cttctctaaa accctgtgtt cacaaaggca gagagtcaga cccttcaatg gaaggagagt 6180 gcttgggatc gattatgtga cttaaagtca gaatagtcct tgggcagttc tcaaatgttg 6240 gagtggaaca ttggggagga aattctgagg caggtattag aaatgaaaag gaaacttgaa 6300 acctgggcat ggtggctcac gcctgtaatc ccagcacttt gggaggccaa ggtgggcaga 6360 tcactggagg tcaggagttc gaaaccagcc tggccaacat ggtgaaaccc catctctact 6420 aaaaatacag aaattagccg gtcatggtgg tggacacctg taatcccagc tactcaggtg 6480 gctaaggcag gagaatcact tcagcccggg aggtggaggt tgcagtgagc caagatcata 6540 ccacggcact ccagcctggg tgacagtgag actgtggctc aaaaaaaaaa aaaaaaaagg 6600 aaaatgaaac taggaaaggt ttcttaaagt ctgagatata tttgctagat ttctaaagaa 6660 tgtgttctaa aacagcagaa gattttcaag aaccggtttc caaagacagt cttctaattc 6720 ctcattagta ataagtaaaa tgtttattgt tgtagctctg gtatataatc cattcctctt 6780 aaaatataag acctctggca tgaatatttc atatctataa aatgacagat cccaccagga 6840 aggaagctgt tgctttcttt gaggtgattt ttttcctttg ctccctgttg ctgaaaccat 6900 acagcttcat aaataatttt gcttgctgaa ggaagaaaaa gtgtttttca taaacccatt 6960 atccaggact gtttatagct gttggaagga ctaggtcttc cctagccccc ccagtgtgca 7020 agggcagtga agacttgatt gtacaaaata cgttttgtaa atgttgtgct gttaacactg 7080 caaataaact tggtagcaaa ca 7102 <210> 570 <211> 7108 <212> DNA <213> Homo sapiens <400> 570 aaaactgcga ctgcgcggcg tgagctcgct gagacttcct ggaccccgca ccaggctgtg 60 gggtttctca gataactggg cccctgcgct caggaggcct tcaccctctg ctctgggtaa 120 agttcattgg aacagaaaga aatggattta tctgctcttc gcgttgaaga agtacaaaat 180 gtcattaatg ctatgcagaa aatcttagag tgtcccatct gtctggagtt gatcaaggaa 240 cctgtctcca caaagtgtga ccacatattt tgcaaatttt gcatgctgaa acttctcaac 300 cagaagaaag ggccttcaca gtgtccttta tgtaagaatg atataaccaa aaggagccta 360 caagaaagta cgagatttag tcaacttgtt gaagagctat tgaaaatcat ttgtgctttt 420 cagcttgaca caggtttgga gtatgcaaac agctataatt ttgcaaaaaa ggaaaataac 480 tctcctgaac atctaaaaga tgaagtttct atcatccaaa gtatgggcta cagaaaccgt 540 gccaaaagac ttctacagag tgaacccgaa aatccttcct tgcaggaaac cagtctcagt 600 gtccaactct ctaaccttgg aactgtgaga actctgagga caaagcagcg gatacaacct 660 caaaagacgt ctgtctacat tgaattggga tctgattctt ctgaagatac cgttaataag 720 gcaacttatt gcagtgtggg agatcaagaa ttgttacaaa tcacccctca aggaaccagg 780 gatgaaatca gtttggattc tgcaaaaaag gctgcttgtg aattttctga gacggatgta 840 acaaatactg aacatcatca acccagtaat aatgatttga acaccactga gaagcgtgca 900 gctgagaggc atccagaaaa gtatcagggt agttctgttt caaacttgca tgtggagcca 960 tgtggcacaa atactcatgc cagctcatta cagcatgaga acagcagttt attactcact 1020 aaagacagaa tgaatgtaga aaaggctgaa ttctgtaata aaagcaaaca gcctggctta 1080 gcaaggagcc aacataacag atgggctgga agtaaggaaa catgtaatga taggcggact 1140 cccagcacag aaaaaaaggt agatctgaat gctgatcccc tgtgtgagag aaaagaatgg 1200 aataagcaga aactgccatg ctcagagaat cctagagata ctgaagatgt tccttggata 1260 acactaaata gcagcattca gaaagttaat gagtggtttt ccagaagtga tgaactgtta 1320 ggttctgatg actcacatga tggggagtct gaatcaaatg ccaaagtagc tgatgtattg 1380 gacgttctaa atgaggtaga tgaatattct ggttcttcag agaaaataga cttactggcc 1440 agtgatcctc atgaggcttt aatatgtaaa agtgaaagag ttcactccaa atcagtagag 1500 agtaatattg aagacaaaat atttgggaaa acctatcgga agaaggcaag cctccccaac 1560 ttaagccatg taactgaaaa tctaattata ggagcatttg ttactgagcc acagataata 1620 caagagcgtc ccctcacaaa taaattaaag cgtaaaagga gacctacatc aggccttcat 1680 cctgaggatt ttatcaagaa agcagatttg gcagttcaaa agactcctga aatgataaat 1740 cagggaacta accaaacgga gcagaatggt caagtgatga atattactaa tagtggtcat 1800 gagaataaaa caaaaggtga ttctattcag aatgagaaaa atcctaaccc aatagaatca 1860 ctcgaaaaag aatctgcttt caaaacgaaa gctgaaccta taagcagcag tataagcaat 1920 atggaactcg aattaaatat ccacaattca aaagcaccta aaaagaatag gctgaggagg 1980 aagtcttcta ccaggcatat tcatgcgctt gaactagtag tcagtagaaa tctaagccca 2040 cctaattgta ctgaattgca aattgatagt tgttctagca gtgaagagat aaagaaaaaa 2100 aagtacaacc aaatgccagt caggcacagc agaaacctac aactcatgga aggtaaagaa 2160 cctgcaactg gagccaagaa gagtaacaag ccaaatgaac agacaagtaa aagacatgac 2220 agcgatactt tcccagagct gaagttaaca aatgcacctg gttcttttac taagtgttca 2280 aataccagtg aacttaaaga atttgtcaat cctagccttc caagagaaga aaaagaagag 2340 aaactagaaa cagttaaagt gtctaataat gctgaagacc ccaaagatct catgttaagt 2400 ggagaaaggg ttttgcaaac tgaaagatct gtagagagta gcagtatttc attggtacct 2460 ggtactgatt atggcactca ggaaagtatc tcgttactgg aagttagcac tctagggaag 2520 gcaaaaacag aaccaaataa atgtgtgagt cagtgtgcag catttgaaaa ccccaaggga 2580 ctaattcatg gttgttccaa agataataga aatgacacag aaggctttaa gtatccattg 2640 ggacatgaag ttaaccacag tcgggaaaca agcatagaaa tggaagaaag tgaacttgat 2700 gctcagtatt tgcagaatac attcaaggtt tcaaagcgcc agtcatttgc tccgttttca 2760 aatccaggaa atgcagaaga ggaatgtgca acattctctg cccactctgg gtccttaaag 2820 aaacaaagtc caaaagtcac ttttgaatgt gaacaaaagg aagaaaatca aggaaagaat 2880 gagtctaata tcaagcctgt acagacagtt aatatcactg caggctttcc tgtggttggt 2940 cagaaagata agccagttga taatgccaaa tgtagtatca aaggaggctc taggttttgt 3000 ctatcatctc agttcagagg caacgaaact ggactcatta ctccaaataa acatggactt 3060 ttacaaaacc catatcgtat accaccactt tttcccatca agtcatttgt taaaactaaa 3120 tgtaagaaaa atctgctaga ggaaaacttt gaggaacatt caatgtcacc tgaaagagaa 3180 atgggaaatg agaacattcc aagtacagtg agcacaatta gccgtaataa cattagagaa 3240 aatgttttta aagaagccag ctcaagcaat attaatgaag taggttccag tactaatgaa 3300 gtgggctcca gtattaatga aataggttcc agtgatgaaa acattcaagc agaactaggt 3360 agaaacagag ggccaaaatt gaatgctatg cttagattag gggttttgca acctgaggtc 3420 tataaacaaa gtcttcctgg aagtaattgt aagcatcctg aaataaaaaa gcaagaatat 3480 gaagaagtag ttcagactgt taatacagat ttctctccat atctgatttc agataactta 3540 gaacagccta tgggaagtag tcatgcatct caggtttgtt ctgagacacc tgatgacctg 3600 ttagatgatg gtgaaataaa ggaagatact agttttgctg aaaatgacat taaggaaagt 3660 tctgctgttt ttagcaaaag cgtccagaaa ggagagctta gcaggagtcc tagccctttc 3720 acccatacac atttggctca gggttaccga agaggggcca agaaattaga gtcctcagaa 3780 gagaacttat ctagtgagga tgaagagctt ccctgcttcc aacacttgtt atttggtaaa 3840 gtaaacaata taccttctca gtctactagg catagcaccg ttgctaccga gtgtctgtct 3900 aagaacacag aggagaattt attatcattg aagaatagct taaatgactg cagtaaccag 3960 gtaatattgg caaaggcatc tcaggaacat caccttagtg aggaaacaaa atgttctgct 4020 agcttgtttt cttcacagtg cagtgaattg gaagacttga ctgcaaatac aaacacccag 4080 gatcctttct tgattggttc ttccaaacaa atgaggcatc agtctgaaag ccagggagtt 4140 ggtctgagtg acaaggaatt ggtttcagat gatgaagaaa gaggaacggg cttggaagaa 4200 aataatcaag aagagcaaag catggattca aacttaggtg aagcagcatc tgggtgtgag 4260 agtgaaacaa gcgtctctga agactgctca gggctatcct ctcagagtga cattttaacc 4320 actcagcaga gggataccat gcaacataac ctgataaagc tccagcagga aatggctgaa 4380 ctagaagctg tgttagaaca gcatgggagc cagccttcta acagctaccc ttccatcata 4440 agtgactctt ctgcccttga ggacctgcga aatccagaac aaagcacatc agaaaaagca 4500 gtattaactt cacagaaaag tagtgaatac cctataagcc agaatccaga aggcctttct 4560 gctgacaagt ttgaggtgtc tgcagatagt tctaccagta aaaataaaga accaggagtg 4620 gaaaggtcat ccccttctaa atgcccatca ttagatgata ggtggtacat gcacagttgc 4680 tctgggagtc ttcagaatag aaactaccca tctcaagagg agctcattaa ggttgttgat 4740 gtggaggagc aacagctgga agagtctggg ccacacgatt tgacggaaac atcttacttg 4800 ccaaggcaag atctagaggg aaccccttac ctggaatctg gaatcagcct cttctctgat 4860 gaccctgaat ctgatccttc tgaagacaga gccccagagt cagctcgtgt tggcaacata 4920 ccatcttcaa cctctgcatt gaaagttccc caattgaaag ttgcagaatc tgcccagagt 4980 ccagctgctg ctcatactac tgatactgct gggtataatg caatggaaga aagtgtgagc 5040 agggagaagc cagaattgac agcttcaaca gaaagggtca acaaaagaat gtccatggtg 5100 gtgtctggcc tgaccccaga agaatttatg ctcgtgtaca agtttgccag aaaacaccac 5160 atcactttaa ctaatctaat tactgaagag actactcatg ttgttatgaa aacagatgct 5220 gagtttgtgt gtgaacggac actgaaatat tttctaggaa ttgcgggagg aaaatgggta 5280 gttagctatt tctgggtgac ccagtctatt aaagaaagaa aaatgctgaa tgagcatgat 5340 tttgaagtca gaggagatgt ggtcaatgga agaaaccacc aaggtccaaa gcgagcaaga 5400 gaatcccagg acagaaagat cttcaggggg ctagaaatct gttgctatgg gcccttcacc 5460 aacatgccca cagatcaact ggaatggatg gtacagctgt gtggtgcttc tgtggtgaag 5520 gagctttcat cattcaccct tggcacaggt gtccacccaa ttgtggttgt gcagccagat 5580 gcctggacag aggacaatgg cttccatgca attgggcaga tgtgtgaggc acctgtggtg 5640 acccgagagt gggtgttgga cagtgtagca ctctaccagt gccaggagct ggacacctac 5700 ctgatacccc agatccccca cagccactac tgactgcagc cagccacagg tacagagccc 5760 aggaccccaa gaatgagctt acaaagtggc ctttccaggc cctgggagct cctctcactc 5820 ttcagtcctt ctactgtcct ggctactaaa tattttatgt acatcagcct gaaaaggact 5880 tctggctatg caagggtccc ttaaagattt tctgcttgaa gtctcccttg gaaatctgcc 5940 atgagcacaa aattatggta atttttcacc tgagaagatt ttaaaaccat ttaaacgcca 6000 ccaattgagc aagatgctga ttcattattt atcagcccta ttctttctat tcaggctgtt 6060 gttggcttag ggctggaagc acagagtggc ttggcctcaa gagaatagct ggtttcccta 6120 agtttacttc tctaaaaccc tgtgttcaca aaggcagaga gtcagaccct tcaatggaag 6180 gagagtgctt gggatcgatt atgtgactta aagtcagaat agtccttggg cagttctcaa 6240 atgttggagt ggaacattgg ggaggaaatt ctgaggcagg tattagaaat gaaaaggaaa 6300 cttgaaacct gggcatggtg gctcacgcct gtaatcccag cactttggga ggccaaggtg 6360 ggcagatcac tggaggtcag gagttcgaaa ccagcctggc caacatggtg aaaccccatc 6420 tctactaaaa atacagaaat tagccggtca tggtggtgga cacctgtaat cccagctact 6480 caggtggcta aggcaggaga atcacttcag cccgggaggt ggaggttgca gtgagccaag 6540 atcataccac ggcactccag cctgggtgac agtgagactg tggctcaaaa aaaaaaaaaa 6600 aaaaggaaaa tgaaactagg aaaggtttct taaagtctga gatatatttg ctagatttct 6660 aaagaatgtg ttctaaaaca gcagaagatt ttcaagaacc ggtttccaaa gacagtcttc 6720 taattcctca ttagtaataa gtaaaatgtt tattgttgta gctctggtat ataatccatt 6780 cctcttaaaa tataagacct ctggcatgaa tatttcatat ctataaaatg acagatccca 6840 ccaggaagga agctgttgct ttctttgagg tgattttttt cctttgctcc ctgttgctga 6900 aaccatacag cttcataaat aattttgctt gctgaaggaa gaaaaagtgt ttttcataaa 6960 cccattatcc aggactgttt atagctgttg gaaggactag gtcttcccta gcccccccag 7020 tgtgcaaggg cagtgaagac ttgattgtac aaaatacgtt ttgtaaatgt tgtgctgtta 7080 acactgcaaa taaacttggt agcaaaca 7108 <210> 571 <211> 7224 <212> DNA <213> Homo sapiens <400> 571 aaaactgcga ctgcgcggcg tgagctcgct gagacttcct ggaccccgca ccaggctgtg 60 gggtttctca gataactggg cccctgcgct caggaggcct tcaccctctg ctctgggtaa 120 agttcattgg aacagaaaga aatggattta tctgctcttc gcgttgaaga agtacaaaat 180 gtcattaatg ctatgcagaa aatcttagag tgtcccatct gtctggagtt gatcaaggaa 240 cctgtctcca caaagtgtga ccacatattt tgcaaggtct tactctgttg tcccagctgg 300 agtacagtgg tgcgatcatg aggcttactg ttgccttgac ctcctaggct caagcgatcc 360 tatcacctca gtctcccaag tagctgggac tattttgcat gctgaaactt ctcaaccaga 420 agaaagggcc ttcacagtgt cctttatgta agaatgatat aaccaaaagg agcctacaag 480 aaagtacgag atttagtcaa cttgttgaag agctattgaa aatcatttgt gcttttcagc 540 ttgacacagg tttggagtat gcaaacagct ataattttgc aaaaaaggaa aataactctc 600 ctgaacatct aaaagatgaa gtttctatca tccaaagtat gggctacaga aaccgtgcca 660 aaagacttct acagagtgaa cccgaaaatc cttccttgca ggaaaccagt ctcagtgtcc 720 aactctctaa ccttggaact gtgagaactc tgaggacaaa gcagcggata caacctcaaa 780 agacgtctgt ctacattgaa ttgggatctg attcttctga agataccgtt aataaggcaa 840 cttattgcag tgtgggagat caagaattgt tacaaatcac ccctcaagga accagggatg 900 aaatcagttt ggattctgca aaaaaggctg cttgtgaatt ttctgagacg gatgtaacaa 960 atactgaaca tcatcaaccc agtaataatg atttgaacac cactgagaag cgtgcagctg 1020 agaggcatcc agaaaagtat cagggtagtt ctgtttcaaa cttgcatgtg gagccatgtg 1080 gcacaaatac tcatgccagc tcattacagc atgagaacag cagtttatta ctcactaaag 1140 acagaatgaa tgtagaaaag gctgaattct gtaataaaag caaacagcct ggcttagcaa 1200 ggagccaaca taacagatgg gctggaagta aggaaacatg taatgatagg cggactccca 1260 gcacagaaaa aaaggtagat ctgaatgctg atcccctgtg tgagagaaaa gaatggaata 1320 agcagaaact gccatgctca gagaatccta gagatactga agatgttcct tggataacac 1380 taaatagcag cattcagaaa gttaatgagt ggttttccag aagtgatgaa ctgttaggtt 1440 ctgatgactc acatgatggg gagtctgaat caaatgccaa agtagctgat gtattggacg 1500 ttctaaatga ggtagatgaa tattctggtt cttcagagaa aatagactta ctggccagtg 1560 atcctcatga ggctttaata tgtaaaagtg aaagagttca ctccaaatca gtagagagta 1620 atattgaaga caaaatattt gggaaaacct atcggaagaa ggcaagcctc cccaacttaa 1680 gccatgtaac tgaaaatcta attataggag catttgttac tgagccacag ataatacaag 1740 agcgtcccct cacaaataaa ttaaagcgta aaaggagacc tacatcaggc cttcatcctg 1800 aggattttat caagaaagca gatttggcag ttcaaaagac tcctgaaatg ataaatcagg 1860 gaactaacca aacggagcag aatggtcaag tgatgaatat tactaatagt ggtcatgaga 1920 ataaaacaaa aggtgattct attcagaatg agaaaaatcc taacccaata gaatcactcg 1980 aaaaagaatc tgctttcaaa acgaaagctg aacctataag cagcagtata agcaatatgg 2040 aactcgaatt aaatatccac aattcaaaag cacctaaaaa gaataggctg aggaggaagt 2100 cttctaccag gcatattcat gcgcttgaac tagtagtcag tagaaatcta agcccaccta 2160 attgtactga attgcaaatt gatagttgtt ctagcagtga agagataaag aaaaaaaagt 2220 acaaccaaat gccagtcagg cacagcagaa acctacaact catggaaggt aaagaacctg 2280 caactggagc caagaagagt aacaagccaa atgaacagac aagtaaaaga catgacagcg 2340 atactttccc agagctgaag ttaacaaatg cacctggttc ttttactaag tgttcaaata 2400 ccagtgaact taaagaattt gtcaatccta gccttccaag agaagaaaaa gaagagaaac 2460 tagaaacagt taaagtgtct aataatgctg aagaccccaa agatctcatg ttaagtggag 2520 aaagggtttt gcaaactgaa agatctgtag agagtagcag tatttcattg gtacctggta 2580 ctgattatgg cactcaggaa agtatctcgt tactggaagt tagcactcta gggaaggcaa 2640 aaacagaacc aaataaatgt gtgagtcagt gtgcagcatt tgaaaacccc aagggactaa 2700 ttcatggttg ttccaaagat aatagaaatg acacagaagg ctttaagtat ccattgggac 2760 atgaagttaa ccacagtcgg gaaacaagca tagaaatgga agaaagtgaa cttgatgctc 2820 agtatttgca gaatacattc aaggtttcaa agcgccagtc atttgctccg ttttcaaatc 2880 caggaaatgc agaagaggaa tgtgcaacat tctctgccca ctctgggtcc ttaaagaaac 2940 aaagtccaaa agtcactttt gaatgtgaac aaaaggaaga aaatcaagga aagaatgagt 3000 ctaatatcaa gcctgtacag acagttaata tcactgcagg ctttcctgtg gttggtcaga 3060 aagataagcc agttgataat gccaaatgta gtatcaaagg aggctctagg ttttgtctat 3120 catctcagtt cagaggcaac gaaactggac tcattactcc aaataaacat ggacttttac 3180 aaaacccata tcgtatacca ccactttttc ccatcaagtc atttgttaaa actaaatgta 3240 agaaaaatct gctagaggaa aactttgagg aacattcaat gtcacctgaa agagaaatgg 3300 gaaatgagaa cattccaagt acagtgagca caattagccg taataacatt agagaaaatg 3360 tttttaaaga agccagctca agcaatatta atgaagtagg ttccagtact aatgaagtgg 3420 gctccagtat taatgaaata ggttccagtg atgaaaacat tcaagcagaa ctaggtagaa 3480 acagagggcc aaaattgaat gctatgctta gattaggggt tttgcaacct gaggtctata 3540 aacaaagtct tcctggaagt aattgtaagc atcctgaaat aaaaaagcaa gaatatgaag 3600 aagtagttca gactgttaat acagatttct ctccatatct gatttcagat aacttagaac 3660 agcctatggg aagtagtcat gcatctcagg tttgttctga gacacctgat gacctgttag 3720 atgatggtga aataaaggaa gatactagtt ttgctgaaaa tgacattaag gaaagttctg 3780 ctgtttttag caaaagcgtc cagaaaggag agcttagcag gagtcctagc cctttcaccc 3840 atacacattt ggctcagggt taccgaagag gggccaagaa attagagtcc tcagaagaga 3900 acttatctag tgaggatgaa gagcttccct gcttccaaca cttgttattt ggtaaagtaa 3960 acaatatacc ttctcagtct actaggcata gcaccgttgc taccgagtgt ctgtctaaga 4020 acacagagga gaatttatta tcattgaaga atagcttaaa tgactgcagt aaccaggtaa 4080 tattggcaaa ggcatctcag gaacatcacc ttagtgagga aacaaaatgt tctgctagct 4140 tgttttcttc acagtgcagt gaattggaag acttgactgc aaatacaaac acccaggatc 4200 ctttcttgat tggttcttcc aaacaaatga ggcatcagtc tgaaagccag ggagttggtc 4260 tgagtgacaa ggaattggtt tcagatgatg aagaaagagg aacgggcttg gaagaaaata 4320 atcaagaaga gcaaagcatg gattcaaact taggtgaagc agcatctggg tgtgagagtg 4380 aaacaagcgt ctctgaagac tgctcagggc tatcctctca gagtgacatt ttaaccactc 4440 agcagaggga taccatgcaa cataacctga taaagctcca gcaggaaatg gctgaactag 4500 aagctgtgtt agaacagcat gggagccagc cttctaacag ctacccttcc atcataagtg 4560 actcttctgc ccttgaggac ctgcgaaatc cagaacaaag cacatcagaa aaagcagtat 4620 taacttcaca gaaaagtagt gaatacccta taagccagaa tccagaaggc ctttctgctg 4680 acaagtttga ggtgtctgca gatagttcta ccagtaaaaa taaagaacca ggagtggaaa 4740 ggtcatcccc ttctaaatgc ccatcattag atgataggtg gtacatgcac agttgctctg 4800 ggagtcttca gaatagaaac tacccatctc aagaggagct cattaaggtt gttgatgtgg 4860 aggagcaaca gctggaagag tctgggccac acgatttgac ggaaacatct tacttgccaa 4920 ggcaagatct agagggaacc ccttacctgg aatctggaat cagcctcttc tctgatgacc 4980 ctgaatctga tccttctgaa gacagagccc cagagtcagc tcgtgttggc aacataccat 5040 cttcaacctc tgcattgaaa gttccccaat tgaaagttgc agaatctgcc cagagtccag 5100 ctgctgctca tactactgat actgctgggt ataatgcaat ggaagaaagt gtgagcaggg 5160 agaagccaga attgacagct tcaacagaaa gggtcaacaa aagaatgtcc atggtggtgt 5220 ctggcctgac cccagaagaa tttatgctcg tgtacaagtt tgccagaaaa caccacatca 5280 ctttaactaa tctaattact gaagagacta ctcatgttgt tatgaaaaca gatgctgagt 5340 ttgtgtgtga acggacactg aaatattttc taggaattgc gggaggaaaa tgggtagtta 5400 gctatttctg ggtgacccag tctattaaag aaagaaaaat gctgaatgag catgattttg 5460 aagtcagagg agatgtggtc aatggaagaa accaccaagg tccaaagcga gcaagagaat 5520 cccaggacag aaagatcttc agggggctag aaatctgttg ctatgggccc ttcaccaaca 5580 tgcccacaga tcaactggaa tggatggtac agctgtgtgg tgcttctgtg gtgaaggagc 5640 tttcatcatt cacccttggc acaggtgtcc acccaattgt ggttgtgcag ccagatgcct 5700 ggacagagga caatggcttc catgcaattg ggcagatgtg tgaggcacct gtggtgaccc 5760 gagagtgggt gttggacagt gtagcactct accagtgcca ggagctggac acctacctga 5820 taccccagat cccccacagc cactactgac tgcagccagc cacaggtaca gagccacagg 5880 accccaagat gagcttacaa agtggccttt ccaggccctg ggagctcctc tcactcttca 5940 gtccttctac tgtcctggct actaaatatt ttatgtacat cagcctgaaa aggacttctg 6000 gctatgcaag ggtcccttaa agattttctg cttgaagtct cccttggaaa tctgccatga 6060 gcacaaaatt atggtaattt ttcacctgag aagattttaa aaccatttaa acgccaccaa 6120 ttgagcaaga tgctgattca ttatttatca gccctattct ttctattcag gctgttgttg 6180 gcttagggct ggaagcacag agtggcttgg cctcaagaga atagctggtt tccctaagtt 6240 tacttctcta aaaccctgtg ttcacaaagg cagagagtca gacccttcaa tggaaggaga 6300 gtgcttggga tcgattatgt gacttaaagt cagaatagtc cttgggcagt tctcaaatgt 6360 tggagtggaa cattggggag gaaattctga ggcaggtatt agaaatgaaa aggaaacttg 6420 aaacctgggc atggtggctc acgcctgtaa tcccagcact ttgggaggcc aaggtgggca 6480 gatcactgga ggtcaggagt tcgaaaccag cctggccaac atggtgaaac cccatctcta 6540 ctaaaaatac agaaattagc cggtcatggt ggtggacacc tgtaatccca gctactcagg 6600 tggctaaggc aggagaatca cttcagcccg ggaggtggag gttgcagtga gccaagatca 6660 taccacggca ctccagcctg ggtgacagtg agactgtggc tcaaaaaaaa aaaaaaaaaa 6720 ggaaaatgaa actaggaaag gtttcttaaa gtctgagata tatttgctag atttctaaag 6780 aatgtgttct aaaacagcag aagattttca agaaccggtt tccaaagaca gtcttctaat 6840 tcctcattag taataagtaa aatgtttatt gttgtagctc tggtatataa tccattcctc 6900 ttaaaatata agacctctgg catgaatatt tcatatctat aaaatgacag atcccaccag 6960 gaaggaagct gttgctttct ttgaggtgat ttttttcctt tgctccctgt tgctgaaacc 7020 atacagcttc ataaataatt ttgcttgctg aaggaagaaa aagtgttttt cataaaccca 7080 ttatccagga ctgtttatag ctgttggaag gactaggtct tccctagccc ccccagtgtg 7140 caagggcagt gaagacttga ttgtacaaaa tacgttttgt aaatgttgtg ctgttaacac 7200 tgcaaataaa cttggtagca aaca 7224 <210> 572 <211> 6986 <212> DNA <213> Homo sapiens <400> 572 aaaactgcga ctgcgcggcg tgagctcgct gagacttcct ggaccccgca ccaggctgtg 60 gggtttctca gataactggg cccctgcgct caggaggcct tcaccctctg ctctgggtaa 120 agttcattgg aacagaaaga aatggattta tctgctcttc gcgttgaaga agtacaaaat 180 gtcattaatg ctatgcagaa aatcttagag tgtcccatct gtctggagtt gatcaaggaa 240 cctgtctcca caaagtgtga ccacatattt tgcaaatttt gcatgctgaa acttctcaac 300 cagaagaaag ggccttcaca gtgtccttta tgtaagaatg atataaccaa aaggagccta 360 caagaaagta cgagatttag tcaacttgtt gaagagctat tgaaaatcat ttgtgctttt 420 cagcttgaca caggtttgga gtatgcaaac agctataatt ttgcaaaaaa ggaaaataac 480 tctcctgaac atctaaaaga tgaagtttct atcatccaaa gtatgggcta cagaaaccgt 540 gccaaaagac ttctacagag tgaacccgaa aatccttcct tgcaggaaac cagtctcagt 600 gtccaactct ctaaccttgg aactgtgaga actctgagga caaagcagcg gatacaacct 660 caaaagacgt ctgtctacat tgaattggct gcttgtgaat tttctgagac ggatgtaaca 720 aatactgaac atcatcaacc cagtaataat gatttgaaca ccactgagaa gcgtgcagct 780 gagaggcatc cagaaaagta tcagggtagt tctgtttcaa acttgcatgt ggagccatgt 840 ggcacaaata ctcatgccag ctcattacag catgagaaca gcagtttatt actcactaaa 900 gacagaatga atgtagaaaa ggctgaattc tgtaataaaa gcaaacagcc tggcttagca 960 aggagccaac ataacagatg ggctggaagt aaggaaacat gtaatgatag gcggactccc 1020 agcacagaaa aaaaggtaga tctgaatgct gatcccctgt gtgagagaaa agaatggaat 1080 aagcagaaac tgccatgctc agagaatcct agagatactg aagatgttcc ttggataaca 1140 ctaaatagca gcattcagaa agttaatgag tggttttcca gaagtgatga actgttaggt 1200 tctgatgact cacatgatgg ggagtctgaa tcaaatgcca aagtagctga tgtattggac 1260 gttctaaatg aggtagatga atattctggt tcttcagaga aaatagactt actggccagt 1320 gatcctcatg aggctttaat atgtaaaagt gaaagagttc actccaaatc agtagagagt 1380 aatattgaag acaaaatatt tgggaaaacc tatcggaaga aggcaagcct ccccaactta 1440 agccatgtaa ctgaaaatct aattatagga gcatttgtta ctgagccaca gataatacaa 1500 gagcgtcccc tcacaaataa attaaagcgt aaaaggagac ctacatcagg ccttcatcct 1560 gaggatttta tcaagaaagc agatttggca gttcaaaaga ctcctgaaat gataaatcag 1620 ggaactaacc aaacggagca gaatggtcaa gtgatgaata ttactaatag tggtcatgag 1680 aataaaacaa aaggtgattc tattcagaat gagaaaaatc ctaacccaat agaatcactc 1740 gaaaaagaat ctgctttcaa aacgaaagct gaacctataa gcagcagtat aagcaatatg 1800 gaactcgaat taaatatcca caattcaaaa gcacctaaaa agaataggct gaggaggaag 1860 tcttctacca ggcatattca tgcgcttgaa ctagtagtca gtagaaatct aagcccacct 1920 aattgtactg aattgcaaat tgatagttgt tctagcagtg aagagataaa gaaaaaaaag 1980 tacaaccaaa tgccagtcag gcacagcaga aacctacaac tcatggaagg taaagaacct 2040 gcaactggag ccaagaagag taacaagcca aatgaacaga caagtaaaag acatgacagc 2100 gatactttcc cagagctgaa gttaacaaat gcacctggtt cttttactaa gtgttcaaat 2160 accagtgaac ttaaagaatt tgtcaatcct agccttccaa gagaagaaaa agaagagaaa 2220 ctagaaacag ttaaagtgtc taataatgct gaagacccca aagatctcat gttaagtgga 2280 gaaagggttt tgcaaactga aagatctgta gagagtagca gtatttcatt ggtacctggt 2340 actgattatg gcactcagga aagtatctcg ttactggaag ttagcactct agggaaggca 2400 aaaacagaac caaataaatg tgtgagtcag tgtgcagcat ttgaaaaccc caagggacta 2460 attcatggtt gttccaaaga taatagaaat gacacagaag gctttaagta tccattggga 2520 catgaagtta accacagtcg ggaaacaagc atagaaatgg aagaaagtga acttgatgct 2580 cagtatttgc agaatacatt caaggtttca aagcgccagt catttgctcc gttttcaaat 2640 ccaggaaatg cagaagagga atgtgcaaca ttctctgccc actctgggtc cttaaagaaa 2700 caaagtccaa aagtcacttt tgaatgtgaa caaaaggaag aaaatcaagg aaagaatgag 2760 tctaatatca agcctgtaca gacagttaat atcactgcag gctttcctgt ggttggtcag 2820 aaagataagc cagttgataa tgccaaatgt agtatcaaag gaggctctag gttttgtcta 2880 tcatctcagt tcagaggcaa cgaaactgga ctcattactc caaataaaca tggactttta 2940 caaaacccat atcgtatacc accacttttt cccatcaagt catttgttaa aactaaatgt 3000 aagaaaaatc tgctagagga aaactttgag gaacattcaa tgtcacctga aagagaaatg 3060 ggaaatgaga acattccaag tacagtgagc acaattagcc gtaataacat tagagaaaat 3120 gtttttaaag aagccagctc aagcaatatt aatgaagtag gttccagtac taatgaagtg 3180 ggctccagta ttaatgaaat aggttccagt gatgaaaaca ttcaagcaga actaggtaga 3240 aacagagggc caaaattgaa tgctatgctt agattagggg ttttgcaacc tgaggtctat 3300 aaacaaagtc ttcctggaag taattgtaag catcctgaaa taaaaaagca agaatatgaa 3360 gaagtagttc agactgttaa tacagatttc tctccatatc tgatttcaga taacttagaa 3420 cagcctatgg gaagtagtca tgcatctcag gtttgttctg agacacctga tgacctgtta 3480 gatgatggtg aaataaagga agatactagt tttgctgaaa atgacattaa ggaaagttct 3540 gctgttttta gcaaaagcgt ccagaaagga gagcttagca ggagtcctag ccctttcacc 3600 catacacatt tggctcaggg ttaccgaaga ggggccaaga aattagagtc ctcagaagag 3660 aacttatcta gtgaggatga agagcttccc tgcttccaac acttgttatt tggtaaagta 3720 aacaatatac cttctcagtc tactaggcat agcaccgttg ctaccgagtg tctgtctaag 3780 aacacagagg agaatttatt atcattgaag aatagcttaa atgactgcag taaccaggta 3840 atattggcaa aggcatctca ggaacatcac cttagtgagg aaacaaaatg ttctgctagc 3900 ttgttttctt cacagtgcag tgaattggaa gacttgactg caaatacaaa cacccaggat 3960 cctttcttga ttggttcttc caaacaaatg aggcatcagt ctgaaagcca gggagttggt 4020 ctgagtgaca aggaattggt ttcagatgat gaagaaagag gaacgggctt ggaagaaaat 4080 aatcaagaag agcaaagcat ggattcaaac ttaggtgaag cagcatctgg gtgtgagagt 4140 gaaacaagcg tctctgaaga ctgctcaggg ctatcctctc agagtgacat tttaaccact 4200 cagcagaggg ataccatgca acataacctg ataaagctcc agcaggaaat ggctgaacta 4260 gaagctgtgt tagaacagca tgggagccag ccttctaaca gctacccttc catcataagt 4320 gactcttctg cccttgagga cctgcgaaat ccagaacaaa gcacatcaga aaaagcagta 4380 ttaacttcac agaaaagtag tgaataccct ataagccaga atccagaagg cctttctgct 4440 gacaagtttg aggtgtctgc agatagttct accagtaaaa ataaagaacc aggagtggaa 4500 aggtcatccc cttctaaatg cccatcatta gatgataggt ggtacatgca cagttgctct 4560 gggagtcttc agaatagaaa ctacccatct caagaggagc tcattaaggt tgttgatgtg 4620 gaggagcaac agctggaaga gtctgggcca cacgatttga cggaaacatc ttacttgcca 4680 aggcaagatc tagagggaac cccttacctg gaatctggaa tcagcctctt ctctgatgac 4740 cctgaatctg atccttctga agacagagcc ccagagtcag ctcgtgttgg caacatacca 4800 tcttcaacct ctgcattgaa agttccccaa ttgaaagttg cagaatctgc ccagagtcca 4860 gctgctgctc atactactga tactgctggg tataatgcaa tggaagaaag tgtgagcagg 4920 gagaagccag aattgacagc ttcaacagaa agggtcaaca aaagaatgtc catggtggtg 4980 tctggcctga ccccagaaga atttatgctc gtgtacaagt ttgccagaaa acaccacatc 5040 actttaacta atctaattac tgaagagact actcatgttg ttatgaaaac agatgctgag 5100 tttgtgtgtg aacggacact gaaatatttt ctaggaattg cgggaggaaa atgggtagtt 5160 agctatttct gggtgaccca gtctattaaa gaaagaaaaa tgctgaatga gcatgatttt 5220 gaagtcagag gagatgtggt caatggaaga aaccaccaag gtccaaagcg agcaagagaa 5280 tcccaggaca gaaagatctt cagggggcta gaaatctgtt gctatgggcc cttcaccaac 5340 atgcccacag atcaactgga atggatggta cagctgtgtg gtgcttctgt ggtgaaggag 5400 ctttcatcat tcacccttgg cacaggtgtc cacccaattg tggttgtgca gccagatgcc 5460 tggacagagg acaatggctt ccatgcaatt gggcagatgt gtgaggcacc tgtggtgacc 5520 cgagagtggg tgttggacag tgtagcactc taccagtgcc aggagctgga cacctacctg 5580 ataccccaga tcccccacag ccactactga ctgcagccag ccacaggtac agagccacag 5640 accccaagaa tgagcttaca aagtggcctt tccaggccct gggagctcct ctcactcttc 5700 agtccttcta ctgtcctggc tactaaatat tttatgtaca tcagcctgaa aaggacttct 5760 ggctatgcaa gggtccctta aagattttct gcttgaagtc tcccttggaa atctgccatg 5820 agcacaaaat tatggtaatt tttcacctga gaagatttta aaaccattta aacgccacca 5880 attgagcaag atgctgattc attatttatc agccctattc tttctattca ggctgttgtt 5940 ggcttagggc tggaagcaca gagtggcttg gcctcaagag aatagctggt ttccctaagt 6000 ttacttctct aaaaccctgt gttcacaaag gcagagagtc agacccttca atggaaggag 6060 agtgcttggg atcgattatg tgacttaaag tcagaatagt ccttgggcag ttctcaaatg 6120 ttggagtgga acattgggga ggaaattctg aggcaggtat tagaaatgaa aaggaaactt 6180 gaaacctggg catggtggct cacgcctgta atcccagcac tttgggaggc caaggtgggc 6240 agatcactgg aggtcaggag ttcgaaacca gcctggccaa catggtgaaa ccccatctct 6300 actaaaaata cagaaattag ccggtcatgg tggtggacac ctgtaatccc agctactcag 6360 gtggctaagg caggagaatc acttcagccc gggaggtgga ggttgcagtg agccaagatc 6420 ataccacggc actccagcct gggtgacagt gagactgtgg ctcaaaaaaa aaaaaaaaaa 6480 aggaaaatga aactaggaaa ggtttcttaa agtctgagat atatttgcta gatttctaaa 6540 gaatgtgttc taaaacagca gaagattttc aagaaccggt ttccaaagac agtcttctaa 6600 ttcctcatta gtaataagta aaatgtttat tgttgtagct ctggtatata atccattcct 6660 cttaaaatat aagacctctg gcatgaatat ttcatatcta taaaatgaca gatcccacca 6720 ggaaggaagc tgttgctttc tttgaggtga tttttttcct ttgctccctg ttgctgaaac 6780 catacagctt cataaataat tttgcttgct gaaggaagaa aaagtgtttt tcataaaccc 6840 attatccagg actgtttata gctgttggaa ggactaggtc ttccctagcc cccccagtgt 6900 gcaagggcag tgaagacttg attgtacaaa atacgttttg taaatgttgt gctgttaaca 6960 ctgcaaataa acttggtagc aaacag 6986 <210> 573 <211> 6419 <212> DNA <213> Homo sapiens <400> 573 aaaactgcga ctgcgcggcg tgagctcgct gagacttcct ggaccccgca ccaggctgtg 60 gggtttctca gataactggg cccctgcgct caggaggcct tcaccctctg ctctgggtaa 120 agctgcttgt gaattttctg agacggatgt aacaaatact gaacatcatc aacccagtaa 180 taatgatttg aacaccactg agaagcgtgc agctgagagg catccagaaa agtatcaggg 240 tagttctgtt tcaaacttgc atgtggagcc atgtggcaca aatactcatg ccagctcatt 300 acagcatgag aacagcagtt tattactcac taaagacaga atgaatgtag aaaaggctga 360 attctgtaat aaaagcaaac agcctggctt agcaaggagc caacataaca gatgggctgg 420 aagtaaggaa acatgtaatg ataggcggac tcccagcaca gaaaaaaagg tagatctgaa 480 tgctgatccc ctgtgtgaga gaaaagaatg gaataagcag aaactgccat gctcagagaa 540 tcctagagat actgaagatg ttccttggat aacactaaat agcagcattc agaaagttaa 600 tgagtggttt tccagaagtg atgaactgtt aggttctgat gactcacatg atggggagtc 660 tgaatcaaat gccaaagtag ctgatgtatt ggacgttcta aatgaggtag atgaatattc 720 tggttcttca gagaaaatag acttactggc cagtgatcct catgaggctt taatatgtaa 780 aagtgaaaga gttcactcca aatcagtaga gagtaatatt gaagacaaaa tatttgggaa 840 aacctatcgg aagaaggcaa gcctccccaa cttaagccat gtaactgaaa atctaattat 900 aggagcattt gttactgagc cacagataat acaagagcgt cccctcacaa ataaattaaa 960 gcgtaaaagg agacctacat caggccttca tcctgaggat tttatcaaga aagcagattt 1020 ggcagttcaa aagactcctg aaatgataaa tcagggaact aaccaaacgg agcagaatgg 1080 tcaagtgatg aatattacta atagtggtca tgagaataaa acaaaaggtg attctattca 1140 gaatgagaaa aatcctaacc caatagaatc actcgaaaaa gaatctgctt tcaaaacgaa 1200 agctgaacct ataagcagca gtataagcaa tatggaactc gaattaaata tccacaattc 1260 aaaagcacct aaaaagaata ggctgaggag gaagtcttct accaggcata ttcatgcgct 1320 tgaactagta gtcagtagaa atctaagccc acctaattgt actgaattgc aaattgatag 1380 ttgttctagc agtgaagaga taaagaaaaa aaagtacaac caaatgccag tcaggcacag 1440 cagaaaccta caactcatgg aaggtaaaga acctgcaact ggagccaaga agagtaacaa 1500 gccaaatgaa cagacaagta aaagacatga cagcgatact ttcccagagc tgaagttaac 1560 aaatgcacct ggttctttta ctaagtgttc aaataccagt gaacttaaag aatttgtcaa 1620 tcctagcctt ccaagagaag aaaaagaaga gaaactagaa acagttaaag tgtctaataa 1680 tgctgaagac cccaaagatc tcatgttaag tggagaaagg gttttgcaaa ctgaaagatc 1740 tgtagagagt agcagtattt cattggtacc tggtactgat tatggcactc aggaaagtat 1800 ctcgttactg gaagttagca ctctagggaa ggcaaaaaca gaaccaaata aatgtgtgag 1860 tcagtgtgca gcatttgaaa accccaaggg actaattcat ggttgttcca aagataatag 1920 aaatgacaca gaaggcttta agtatccatt gggacatgaa gttaaccaca gtcgggaaac 1980 aagcatagaa atggaagaaa gtgaacttga tgctcagtat ttgcagaata cattcaaggt 2040 ttcaaagcgc cagtcatttg ctccgttttc aaatccagga aatgcagaag aggaatgtgc 2100 aacattctct gcccactctg ggtccttaaa gaaacaaagt ccaaaagtca cttttgaatg 2160 tgaacaaaag gaagaaaatc aaggaaagaa tgagtctaat atcaagcctg tacagacagt 2220 taatatcact gcaggctttc ctgtggttgg tcagaaagat aagccagttg ataatgccaa 2280 atgtagtatc aaaggaggct ctaggttttg tctatcatct cagttcagag gcaacgaaac 2340 tggactcatt actccaaata aacatggact tttacaaaac ccatatcgta taccaccact 2400 ttttcccatc aagtcatttg ttaaaactaa atgtaagaaa aatctgctag aggaaaactt 2460 tgaggaacat tcaatgtcac ctgaaagaga aatgggaaat gagaacattc caagtacagt 2520 gagcacaatt agccgtaata acattagaga aaatgttttt aaagaagcca gctcaagcaa 2580 tattaatgaa gtaggttcca gtactaatga agtgggctcc agtattaatg aaataggttc 2640 cagtgatgaa aacattcaag cagaactagg tagaaacaga gggccaaaat tgaatgctat 2700 gcttagatta ggggttttgc aacctgaggt ctataaacaa agtcttcctg gaagtaattg 2760 taagcatcct gaaataaaaa agcaagaata tgaagaagta gttcagactg ttaatacaga 2820 tttctctcca tatctgattt cagataactt agaacagcct atgggaagta gtcatgcatc 2880 tcaggtttgt tctgagacac ctgatgacct gttagatgat ggtgaaataa aggaagatac 2940 tagttttgct gaaaatgaca ttaaggaaag ttctgctgtt tttagcaaaa gcgtccagaa 3000 aggagagctt agcaggagtc ctagcccttt cacccataca catttggctc agggttaccg 3060 aagaggggcc aagaaattag agtcctcaga agagaactta tctagtgagg atgaagagct 3120 tccctgcttc caacacttgt tatttggtaa agtaaacaat ataccttctc agtctactag 3180 gcatagcacc gttgctaccg agtgtctgtc taagaacaca gaggagaatt tattatcatt 3240 gaagaatagc ttaaatgact gcagtaacca ggtaatattg gcaaaggcat ctcaggaaca 3300 tcaccttagt gaggaaacaa aatgttctgc tagcttgttt tcttcacagt gcagtgaatt 3360 ggaagacttg actgcaaata caaacaccca ggatcctttc ttgattggtt cttccaaaca 3420 aatgaggcat cagtctgaaa gccagggagt tggtctgagt gacaaggaat tggtttcaga 3480 tgatgaagaa agaggaacgg gcttggaaga aaataatcaa gaagagcaaa gcatggattc 3540 aaacttaggt gaagcagcat ctgggtgtga gagtgaaaca agcgtctctg aagactgctc 3600 agggctatcc tctcagagtg acattttaac cactcagcag agggatacca tgcaacataa 3660 cctgataaag ctccagcagg aaatggctga actagaagct gtgttagaac agcatgggag 3720 ccagccttct aacagctacc cttccatcat aagtgactct tctgcccttg aggacctgcg 3780 aaatccagaa caaagcacat cagaaaaagc agtattaact tcacagaaaa gtagtgaata 3840 ccctataagc cagaatccag aaggcctttc tgctgacaag tttgaggtgt ctgcagatag 3900 ttctaccagt aaaaataaag aaccaggagt ggaaaggtca tccccttcta aatgcccatc 3960 attagatgat aggtggtaca tgcacagttg ctctgggagt cttcagaata gaaactaccc 4020 atctcaagag gagctcatta aggttgttga tgtggaggag caacagctgg aagagtctgg 4080 gccacacgat ttgacggaaa catcttactt gccaaggcaa gatctagagg gaacccctta 4140 cctggaatct ggaatcagcc tcttctctga tgaccctgaa tctgatcctt ctgaagacag 4200 agccccagag tcagctcgtg ttggcaacat accatcttca acctctgcat tgaaagttcc 4260 ccaattgaaa gttgcagaat ctgcccagag tccagctgct gctcatacta ctgatactgc 4320 tgggtataat gcaatggaag aaagtgtgag cagggagaag ccagaattga cagcttcaac 4380 agaaagggtc aacaaaagaa tgtccatggt ggtgtctggc ctgaccccag aagaatttat 4440 gctcgtgtac aagtttgcca gaaaacacca catcacttta actaatctaa ttactgaaga 4500 gactactcat gttgttatga aaacagatgc tgagtttgtg tgtgaacgga cactgaaata 4560 ttttctagga attgcgggag gaaaatgggt agttagctat ttctgggtga cccagtctat 4620 taaagaaaga aaaatgctga atgagcatga ttttgaagtc agaggagatg tggtcaatgg 4680 aagaaaccac caaggtccaa agcgagcaag agaatcccag gacagaaaga tcttcagggg 4740 gctagaaatc tgttgctatg ggcccttcac caacatgccc acagatcaac tggaatggat 4800 ggtacagctg tgtggtgctt ctgtggtgaa ggagctttca tcattcaccc ttggcacagg 4860 tgtccaccca attgtggttg tgcagccaga tgcctggaca gaggacaatg gcttccatgc 4920 aattgggcag atgtgtgagg cacctgtggt gacccgagag tgggtgttgg acagtgtagc 4980 actctaccag tgccaggagc tggacaccta cctgataccc cagatccccc acagccacta 5040 ctgactgcag ccagccacag gtacagagca caggacccca agaatgagct tacaaagtgg 5100 cctttccagg ccctgggagc tcctctcact cttcagtcct tctactgtcc tggctactaa 5160 atattttatg tacatcagcc tgaaaaggac ttctggctat gcaagggtcc cttaaagatt 5220 ttctgcttga agtctccctt ggaaatctgc catgagcaca aaattatggt aatttttcac 5280 ctgagaagat tttaaaacca tttaaacgcc accaattgag caagatgctg attcattatt 5340 tatcagccct attctttcta ttcaggctgt tgttggctta gggctggaag cacagagtgg 5400 cttggcctca agagaatagc tggtttccct aagtttactt ctctaaaacc ctgtgttcac 5460 aaaggcagag agtcagaccc ttcaatggaa ggagagtgct tgggatcgat tatgtgactt 5520 aaagtcagaa tagtccttgg gcagttctca aatgttggag tggaacattg gggaggaaat 5580 tctgaggcag gtattagaaa tgaaaaggaa acttgaaacc tgggcatggt ggctcacgcc 5640 tgtaatccca gcactttggg aggccaaggt gggcagatca ctggaggtca ggagttcgaa 5700 accagcctgg ccaacatggt gaaaccccat ctctactaaa aatacagaaa ttagccggtc 5760 atggtggtgg acacctgtaa tcccagctac tcaggtggct aaggcaggag aatcacttca 5820 gcccgggagg tggaggttgc agtgagccaa gatcatacca cggcactcca gcctgggtga 5880 cagtgagact gtggctcaaa aaaaaaaaaa aaaaaggaaa atgaaactag gaaaggtttc 5940 ttaaagtctg agatatattt gctagatttc taaagaatgt gttctaaaac agcagaagat 6000 tttcaagaac cggtttccaa agacagtctt ctaattcctc attagtaata agtaaaatgt 6060 ttattgttgt agctctggta tataatccat tcctcttaaa atataagacc tctggcatga 6120 atatttcata tctataaaat gacagatccc accaggaagg aagctgttgc tttctttgag 6180 gtgatttttt tcctttgctc cctgttgctg aaaccataca gcttcataaa taattttgct 6240 tgctgaagga agaaaaagtg tttttcataa acccattatc caggactgtt tatagctgtt 6300 ggaaggacta ggtcttccct agccccccca gtgtgcaagg gcagtgaaga cttgattgta 6360 caaaatacgt tttgtaaatg ttgtgctgtt aacactgcaa ataaacttgg tagcaaaca 6419 <210> 574 <211> 5711 <212> DNA <213> Homo sapiens <400> 574 agctcgctga gacttcctgg accccgcacc aggctgtggg gtttctcaga taactgggcc 60 cctgcgctca ggaggccttc accctctgct ctgggtaaag ttcattggaa cagaaagaaa 120 tggatttatc tgctcttcgc gttgaagaag tacaaaatgt cattaatgct atgcagaaaa 180 tcttagagtg tcccatctgt ctggagttga tcaaggaacc tgtctccaca aagtgtgacc 240 acatattttg caaattttgc atgctgaaac ttctcaacca gaagaaaggg ccttcacagt 300 gtcctttatg taagaatgat ataaccaaaa ggagcctaca agaaagtacg agatttagtc 360 aacttgttga agagctattg aaaatcattt gtgcttttca gcttgacaca ggtttggagt 420 atgcaaacag ctataatttt gcaaaaaagg aaaataactc tcctgaacat ctaaaagatg 480 aagtttctat catccaaagt atgggctaca gaaaccgtgc caaaagactt ctacagagtg 540 aacccgaaaa tccttccttg caggaaacca gtctcagtgt ccaactctct aaccttggaa 600 ctgtgagaac tctgaggaca aagcagcgga tacaacctca aaagacgtct gtctacattg 660 aattgggatc tgattcttct gaagataccg ttaataaggc aacttattgc agtgtgggag 720 atcaagaatt gttacaaatc acccctcaag gaaccaggga tgaaatcagt ttggattctg 780 caaaaaaggc tgcttgtgaa ttttctgaga cggatgtaac aaatactgaa catcatcaac 840 ccagtaataa tgatttgaac accactgaga agcgtgcagc tgagaggcat ccagaaaagt 900 atcagggtag ttctgtttca aacttgcatg tggagccatg tggcacaaat actcatgcca 960 gctcattaca gcatgagaac agcagtttat tactcactaa agacagaatg aatgtagaaa 1020 aggctgaatt ctgtaataaa agcaaacagc ctggcttagc aaggagccaa cataacagat 1080 gggctggaag taaggaaaca tgtaatgata ggcggactcc cagcacagaa aaaaaggtag 1140 atctgaatgc tgatcccctg tgtgagagaa aagaatggaa taagcagaaa ctgccatgct 1200 cagagaatcc tagagatact gaagatgttc cttggataac actaaatagc agcattcaga 1260 aagttaatga gtggttttcc agaagtgatg aactgttagg ttctgatgac tcacatgatg 1320 gggagtctga atcaaatgcc aaagtagctg atgtattgga cgttctaaat gaggtagatg 1380 aatattctgg ttcttcagag aaaatagact tactggccag tgatcctcat gaggctttaa 1440 tatgtaaaag tgaaagagtt cactccaaat cagtagagag taatattgaa gacaaaatat 1500 ttgggaaaac ctatcggaag aaggcaagcc tccccaactt aagccatgta actgaaaatc 1560 taattatagg agcatttgtt actgagccac agataataca agagcgtccc ctcacaaata 1620 aattaaagcg taaaaggaga cctacatcag gccttcatcc tgaggatttt atcaagaaag 1680 cagatttggc agttcaaaag actcctgaaa tgataaatca gggaactaac caaacggagc 1740 agaatggtca agtgatgaat attactaata gtggtcatga gaataaaaca aaaggtgatt 1800 ctattcagaa tgagaaaaat cctaacccaa tagaatcact cgaaaaagaa tctgctttca 1860 aaacgaaagc tgaacctata agcagcagta taagcaatat ggaactcgaa ttaaatatcc 1920 acaattcaaa agcacctaaa aagaataggc tgaggaggaa gtcttctacc aggcatattc 1980 atgcgcttga actagtagtc agtagaaatc taagcccacc taattgtact gaattgcaaa 2040 ttgatagttg ttctagcagt gaagagataa agaaaaaaaa gtacaaccaa atgccagtca 2100 ggcacagcag aaacctacaa ctcatggaag gtaaagaacc tgcaactgga gccaagaaga 2160 gtaacaagcc aaatgaacag acaagtaaaa gacatgacag cgatactttc ccagagctga 2220 agttaacaaa tgcacctggt tcttttacta agtgttcaaa taccagtgaa cttaaagaat 2280 ttgtcaatcc tagccttcca agagaagaaa aagaagagaa actagaaaca gttaaagtgt 2340 ctaataatgc tgaagacccc aaagatctca tgttaagtgg agaaagggtt ttgcaaactg 2400 aaagatctgt agagagtagc agtatttcat tggtacctgg tactgattat ggcactcagg 2460 aaagtatctc gttactggaa gttagcactc tagggaaggc aaaaacagaa ccaaataaat 2520 gtgtgagtca gtgtgcagca tttgaaaacc ccaagggact aattcatggt tgttccaaag 2580 ataatagaaa tgacacagaa ggctttaagt atccattggg acatgaagtt aaccacagtc 2640 gggaaacaag catagaaatg gaagaaagtg aacttgatgc tcagtatttg cagaatacat 2700 tcaaggtttc aaagcgccag tcatttgctc cgttttcaaa tccaggaaat gcagaagagg 2760 aatgtgcaac attctctgcc cactctgggt ccttaaagaa acaaagtcca aaagtcactt 2820 ttgaatgtga acaaaaggaa gaaaatcaag gaaagaatga gtctaatatc aagcctgtac 2880 agacagttaa tatcactgca ggctttcctg tggttggtca gaaagataag ccagttgata 2940 atgccaaatg tagtatcaaa ggaggctcta ggttttgtct atcatctcag ttcagaggca 3000 acgaaactgg actcattact ccaaataaac atggactttt acaaaaccca tatcgtatac 3060 caccactttt tcccatcaag tcatttgtta aaactaaatg taagaaaaat ctgctagagg 3120 aaaactttga ggaacattca atgtcacctg aaagagaaat gggaaatgag aacattccaa 3180 gtacagtgag cacaattagc cgtaataaca ttagagaaaa tgtttttaaa gaagccagct 3240 caagcaatat taatgaagta ggttccagta ctaatgaagt gggctccagt attaatgaaa 3300 taggttccag tgatgaaaac attcaagcag aactaggtag aaacagaggg ccaaaattga 3360 atgctatgct tagattaggg gttttgcaac ctgaggtcta taaacaaagt cttcctggaa 3420 gtaattgtaa gcatcctgaa ataaaaaagc aagaatatga agaagtagtt cagactgtta 3480 atacagattt ctctccatat ctgatttcag ataacttaga acagcctatg ggaagtagtc 3540 atgcatctca ggtttgttct gagacacctg atgacctgtt agatgatggt gaaataaagg 3600 aagatactag ttttgctgaa aatgacatta aggaaagttc tgctgttttt agcaaaagcg 3660 tccagaaagg agagcttagc aggagtccta gccctttcac ccatacacat ttggctcagg 3720 gttaccgaag aggggccaag aaattagagt cctcagaaga gaacttatct agtgaggatg 3780 aagagcttcc ctgcttccaa cacttgttat ttggtaaagt aaacaatata ccttctcagt 3840 ctactaggca tagcaccgtt gctaccgagt gtctgtctaa gaacacagag gagaatttat 3900 tatcattgaa gaatagctta aatgactgca gtaaccaggt aatattggca aaggcatctc 3960 aggaacatca ccttagtgag gaaacaaaat gttctgctag cttgttttct tcacagtgca 4020 gtgaattgga agacttgact gcaaatacaa acacccagga tcctttcttg attggttctt 4080 ccaaacaaat gaggcatcag tctgaaagcc agggagttgg tctgagtgac aaggaattgg 4140 tttcagatga tgaagaaaga ggaacgggct tggaagaaaa taatcaagaa gagcaaagca 4200 tggattcaaa cttaggtgaa gcagcatctg ggtgtgagag tgaaacaagc gtctctgaag 4260 actgctcagg gctatcctct cagagtgaca ttttaaccac tcagcagagg gataccatgc 4320 aacataacct gataaagctc cagcaggaaa tggctgaact agaagctgtg ttagaacagc 4380 atgggagcca gccttctaac agctaccctt ccatcataag tgactcttct gcccttgagg 4440 acctgcgaaa tccagaacaa agcacatcag aaaaagcagt attaacttca cagaaaagta 4500 gtgaataccc tataagccag aatccagaag gcctttctgc tgacaagttt gaggtgtctg 4560 cagatagttc taccagtaaa aataaagaac caggagtgga aaggtcatcc ccttctaaat 4620 gcccatcatt agatgatagg tggtacatgc acagttgctc tgggagtctt cagaatagaa 4680 actacccatc tcaagaggag ctcattaagg ttgttgatgt ggaggagcaa cagctggaag 4740 agtctgggcc acacgatttg acggaaacat cttacttgcc aaggcaagat ctagagggaa 4800 ccccttacct ggaatctgga atcagcctct tctctgatga ccctgaatct gatccttctg 4860 aagacagagc cccagagtca gctcgtgttg gcaacatacc atcttcaacc tctgcattga 4920 aagttcccca attgaaagtt gcagaatctg cccagagtcc agctgctgct catactactg 4980 atactgctgg gtataatgca atggaagaaa gtgtgagcag ggagaagcca gaattgacag 5040 cttcaacaga aagggtcaac aaaagaatgt ccatggtggt gtctggcctg accccagaag 5100 aatttatgct cgtgtacaag tttgccagaa aacaccacat cactttaact aatctaatta 5160 ctgaagagac tactcatgtt gttatgaaaa cagatgctga gtttgtgtgt gaacggacac 5220 tgaaatattt tctaggaatt gcgggaggaa aatgggtagt tagctatttc tgggtgaccc 5280 agtctattaa agaaagaaaa atgctgaatg agcatgattt tgaagtcaga ggagatgtgg 5340 tcaatggaag aaaccaccaa ggtccaaagc gagcaagaga atcccaggac agaaagatct 5400 tcagggggct agaaatctgt tgctatgggc ccttcaccaa catgcccaca gatcaactgg 5460 aatggatggt acagctgtgt ggtgcttctg tggtgaagga gctttcatca ttcacccttg 5520 gcacaggtgt ccacccaatt gtggttgtgc agccagatgc ctggacagag gacaatggct 5580 tccatgcaat tgggcagatg tgtgaggcac ctgtggtgac ccgagagtgg gtgttggaca 5640 gtgtagcact ctaccagtgc caggagctgg acacctacct gataccccag atcccccaca 5700 gccactactg a 5711 <210> 575 <211> 5693 <212> DNA <213> Homo sapiens <400> 575 cctctgctct gggtaaagtt agtggagtcc cgggaaaggg acagggggcc caagtgatgc 60 tctggggtac tggcgtggga gagtggattt ccgaagctga cagatggttc attggaacag 120 aaagaaatgg atttatctgc tcttcgcgtt gaagaagtac aaaatgtcat taatgctatg 180 cagaaaatct tagagtgtcc catctgtctg gagttgatca aggaacctgt ctccacaaag 240 tgtgaccaca tattttgcaa attttgcatg ctgaaacttc tcaaccagaa gaaagggcct 300 tcacagtgtc ctttatgagc ctacaagaaa gtacgagatt cagtcaactt gttgaagagc 360 tattgaaaac catttgtgct tttcagcttg acacaggttt ggagtatgca aacagctata 420 attttgcaaa aaaggaaaat aactctcctg aacatctaaa agatgaagtt tctatcatcc 480 aaagtatggg ctacagaaac cgtgccaaaa gacttctaca gagtgaaccc gaaaatcctt 540 ccttggaaac cagtctcagt gtccaactct ctaaccttgg aactgtgaga actctgagga 600 caaagcagcg gatacaacct caaaagacgt ctgtctacat tgaattggga tctgattctt 660 ctgaagatac cgttaataag gcaacttatt gcagtgtggg agatcaagaa ttgttacaaa 720 tcacccctca aggaaccagg gatgaaatca gtttggactc tgcaaaaaag gctgcttgtg 780 aattttctga gacggatgta acaaatactg aacatcatca acccagtaat aatgatttga 840 acaccactga gaagcgtgca gctgagaggc atccagaaaa gtatcagggt agttctgttt 900 caaacttgca tgtggagcca tgtggcacaa atactcatgc cagctcatta cagcatgaga 960 acagcagttt attactcact aaagacagaa tgaatgtaga aaaggctgaa ttctgtaata 1020 aaagcaaaca gcctggctta gcaaggagcc aacataacag atgggctgga agtaaggaaa 1080 catgtaatga taggcggact cccagcacag aaaaaaaggt agatctgaat gctgatcccc 1140 tgtgtgagag aaaagaatgg aataagcaga aactgccatg ctcagagaat cctagagata 1200 ctgaagatgt tccttggata acactaaata gcagcattca gaaagttaat gagtggtttt 1260 ccagaagtga tgaactgtta ggttctgatg actcacatga tggggagtct gaatcaaatg 1320 ccaaagtagc tgatgtattg gacgttctaa atgaggtaga tgaatattct ggttcttcag 1380 agaaaataga cttactggcc agtgatcctc atgaggcttt aatatgtaaa agtgaaagag 1440 ttcactccaa atcagtagag agtaatattg aagacaaaat atttgggaaa acctatcgga 1500 agaaggcaag cctccccaac ttaagccatg taactgaaaa tctaattata ggagcatttg 1560 ttactgagcc acagataata caagagcgtc ccctcacaaa taaattaaag cgtaaaagga 1620 gacctacatc aggccttcat cctgaggatt ttatcaagaa agcagatttg gcagttcaaa 1680 agactcctga aatgataaat cagggaacta accaaacgga gcagaatggt caagtgatga 1740 atattactaa tagtggtcat gagaataaaa caaaaggtga ttctattcag aatgagaaaa 1800 atcctaaccc aatagaatca ctcgaaaaag aatctgcttt caaaacgaaa gctgaaccta 1860 taagcagcag tataagcaat atggaactcg aattaaatat ccacaattca aaagcaccta 1920 aaaagaatag gctgaggagg aagtcttcta ccaggcatat tcatgcgctt gaactagtag 1980 tcagtagaaa tctaagccca cctaattgta ctgaattgca aattgatagt tgttctagca 2040 gtgaagagat aaagaaaaaa aagtacaacc aaatgccagt caggcacagc agaaacctac 2100 aactcatgga aggtaaagaa cctgcaactg gagccaagaa gagtaacaag ccaaatgaac 2160 agacaagtaa aagacatgac agcgatactt tcccagagct gaagttaaca aatgcacctg 2220 gttcttttac taagtgttca aataccagtg aacttaaaga atttgtcaat cctagccttc 2280 caagagaaga aaaagaagag aaactagaaa cagttaaagt gtctaataat gctgaagacc 2340 ccaaagatct catgttaagt ggagaaaggg ttttgcaaac tgaaagatct gtagagagta 2400 gcagtatttc attggtacct ggtactgatt atggcactca ggaaagtatc tcgttactgg 2460 aagttagcac tctagggaag gcaaaaacag aaccaaataa atgtgtgagt cagtgtgcag 2520 catttgaaaa ccccaaggga ctaattcatg gttgttccaa agataataga aatgacacag 2580 aaggctttaa gtatccattg ggacatgaag ttaaccacag tcgggaaaca agcatagaaa 2640 tggaagaaag tgaacttgat gctcagtatt tgcagaatac attcaaggtt tcaaagcgcc 2700 agtcatttgc tccgttttca aatccaggaa atgcagaaga ggaatgtgca acattctctg 2760 cccactctgg gtccttaaag aaacaaagtc caaaagtcac ttttgaatgt gaacaaaagg 2820 aagaaaatca aggaaagaat gagtctaata tcaagcctgt acagacagtt aatatcactg 2880 caggctttcc tgtggttggt cagaaagata agccagttga taatgccaaa tgtagtatca 2940 aaggaggctc taggttttgt ctatcatctc agttcagagg caacgaaact ggactcatta 3000 ctccaaataa acatggactt ttacaaaacc catatcgtat accaccactt tttcccatca 3060 agtcatttgt taaaactaaa tgtaagaaaa atctgctaga ggaaaacttt gaggaacatt 3120 caatgtcacc tgaaagagaa atgggaaatg agaacattcc aagtacagtg agcacaatta 3180 gccgtaataa cattagagaa aatgttttta aagaagccag ctcaagcaat attaatgaag 3240 taggttccag tactaatgaa gtgggctcca gtattaatga aataggttcc agtgatgaaa 3300 acattcaagc agaactaggt agaaacagaa ggcccaaatt gaatgctatg cttagattag 3360 gggttttgca acctgaggtc tataaacaaa gtcttcctgg aagtaattgt aagcatcctg 3420 aaataaaaaa gcaagaatat gaagaagtag ttcagactgt taatacagat ttctctccat 3480 atctgatttc agataactta gaacagccta tgggaagtag tcatgcatct caggtttgtt 3540 ctgagacacc tgatgacctg ttagatgatg gtgaaataaa ggaagatact agttttgctg 3600 aaaatgacat taaggaaagt tctgctgttt ttagcaaaag cgtccagaaa ggagagctta 3660 gcaggagtcc tagccctttc acccatacac atttggctca gggttaccga agaggggcca 3720 agaaattaga gtcctcagaa gagaacttat ctagtgagga tgaagagctt ccctgcttcc 3780 aacacttgtt atttggtaaa gtaaacaata taccttctca gtctactagg catagcaccg 3840 ttgctaccga gtgtctgtct aagaacacag aggagaattt attatcattg aagaatagct 3900 taaatgactg cagtaaccag gtaatattgg caaaggcatc tcaggaacat caccttagtg 3960 aggaaacaaa atgttctgct agcttgtttt cttcacagtg cagtgaattg gaagacttga 4020 ctgcaaatac aaacacccag gatcctttct tgattggttc ttccaaacaa atgaggcatc 4080 agtctgaaag ccagggagtt ggtctgagtg acaaggaatt ggtttcagat gatgaagaaa 4140 gaggaacggg cttggaagaa aataatcaag aagagcaaag catggattca aacttaggtg 4200 aagcagcatc tgggtgtgag agtgaaacaa gcgtctctga agactgctca gggctatcct 4260 ctcagagtga cattttaacc actcagcaga gggataccat gcaacataac ctgataaagc 4320 tccagcagga aatggctgaa ctagaagctg tgttagaaca gcatgggagc cagccttcta 4380 acagctaccc ttccatcata agtgactctt ctgcccttga ggacctgcga aatccagaac 4440 aaagcacatc agaaaaagca gtattaactt cacagaaaag tagtgaatac cctataagcc 4500 agaatccaga aggcctttct gctgacaagt ttgaggtgtc tgcagatagt tctaccagta 4560 aaaataaaga accaggagtg gaaaggtcat ccccttctaa atgcccatca ttagatgata 4620 ggtggtacat gcacagttgc tctgggagtc ttcagaatag aaactaccca tctcaagagg 4680 agctcattaa ggttgttgat gtggaggagc aacagctgga agagtctggg ccacacgatt 4740 tgacggaaac atcttacttg ccaaggcaag atctagaggg aaccccttac ctggaatctg 4800 gaatcagcct cttctctgat gaccctgaat ctgatccttc tgaagacaga gccccagagt 4860 cagctcgtgt tggcaacata ccatcttcaa cctctgcatt gaaagttccc caattgaaag 4920 ttgcagaatc tgcccagagt ccagctgctg ctcatactac tgatactgct gggtataatg 4980 caatggaaga aagtgtgagc agggagaagc cagaattgac agcttcaaca gaaagggtca 5040 acaaaagaat gtccatggtg gtgtctggcc tgaccccaga agaatttatg ctcgtgtaca 5100 agtttgccag aaaacaccac atcactttaa ctaatctaat tactgaagag actactcatg 5160 ttgttatgaa aacagatgct gagtttgtgt gtgaacggac actgaaatat tttctaggaa 5220 ttgcgggagg aaaatgggta gttagctatt tctgggtgac ccagtctatt aaagaaagaa 5280 aaatgctgaa tgagcatgat tttgaagtca gaggagatgt ggtcaatgga agaaaccacc 5340 aaggtccaaa gcgagcaaga gaatcccagg acagaaagat cttcaggggg ctagaaatct 5400 gttgctatgg gcccttcacc aacatgccca cagatcaact ggaatggatg gtacagctgt 5460 gtggtgcttc tgtggtgaag gagctttcat cattcaccct tggcacaggt gtccacccaa 5520 ttgtggttgt gcagccagat gcctggacag aggacaatgg cttccatgca attgggcaga 5580 tgtgtgaggc acctgtggtg acccgagagt gggtgttgga cagtgtagca ctctaccagt 5640 gccaggagct ggacacctac ctgatacccc agatccccca cagccactac tga 5693 <210> 576 <211> 6519 <212> DNA <213> Homo sapiens <400> 576 aaaactgcga ctgcgcggcg tgagctcgct gagacttcct ggaccccgca ccaggctgtg 60 gggtttctca gataactggg cccctgcgct caggaggcct tcaccctctg ctctgggtaa 120 agttcattgg aacagaaaga aatggattta tctgctcttc gcgttgaaga agtacaaaat 180 gtcattaatg ctatgcagaa aatcttagag tgtcccatct gtctggagtt gatcaaggaa 240 cctgtctcca caaagtgtga ccacatattt tgcaaatttt gcatgctgaa acttctcaac 300 cagaagaaag ggccttcaca gtgtccttta tgtaagaatg atataaccaa aaggagccta 360 caagaaagta cgagatttag tcaacttgtt gaagagctat tgaaaatcat ttgtgctttt 420 cagcttgaca caggtttgga gtatgcaaac agctataatt ttgcaaaaaa ggaaaataac 480 tctcctgaac atctaaaaga tgaagtttct atcatccaaa gtatgggcta cagaaaccgt 540 gccaaaagac ttctacagag tgaacccgaa aatccttcct tgcaggaaac cagtctcagt 600 gtccaactct ctaaccttgg aactgtgaga actctgagga caaagcagcg gatacaacct 660 caaaagacgt ctgtctacat tgaattggga tctgattctt ctgaagatac cgttaataag 720 gcaacttatt gcagtgtggg agatcaagaa ttgttacaaa tcacccctca aggaaccagg 780 gatgaaatca gtttggattc tgcaaaaaag gctgcttgtg aattttctga gacggatgta 840 acaaatactg aacatcatca acccagtaat aatgatttga acaccactga gaagcgtgca 900 gctgagaggc atccagaaaa gtatcagggt agttctgttt caaacttgca tgtggagcca 960 tgtggcacaa atactcatgc cagctcatta cagcatgaga acagcagttt attactcact 1020 aaagacagaa tgaatgtaga aaaggctgaa ttctgtaata aaagcaaaca gcctggctta 1080 gcaaggagcc aacataacag atgggctgga agtaaggaaa catgtaatga taggcggact 1140 cccagcacag aaaaaaaggt agatctgaat gctgatcccc tgtgtgagag aaaagaatgg 1200 aataagcaga aactgccatg ctcagagaat cctagagata ctgaagatgt tccttggata 1260 acactaaata gcagcattca gaaagttaat gagtggtttt ccagaagtga tgaactgtta 1320 ggttctgatg actcacatga tggggagtct gaatcaaatg ccaaagtagc tgatgtattg 1380 gacgttctaa atgaggtaga tgaatattct ggttcttcag agaaaataga cttactggcc 1440 agtgatcctc atgaggcttt aatatgtaaa agtgaaagag ttcactccaa atcagtagag 1500 agtaatattg aagacaaaat atttgggaaa acctatcgga agaaggcaag cctccccaac 1560 ttaagccatg taactgaaaa tctaattata ggagcatttg ttactgagcc acagataata 1620 caagagcgtc ccctcacaaa taaattaaag cgtaaaagga gacctacatc aggccttcat 1680 cctgaggatt ttatcaagaa agcagatttg gcagttcaaa agactcctga aatgataaat 1740 cagggaacta accaaacgga gcagaatggt caagtgatga atattactaa tagtggtcat 1800 gagaataaaa caaaaggtga ttctattcag aatgagaaaa atcctaaccc aatagaatca 1860 ctcgaaaaag aatctgcttt caaaacgaaa gctgaaccta taagcagcag tataagcaat 1920 atggaactcg aattaaatat ccacaattca aaagcaccta aaaagaatag gctgaggagg 1980 aagtcttcta ccaggcatat tcatgcgctt gaactagtag tcagtagaaa tctaagccca 2040 cctaattgta ctgaattgca aattgatagt tgttctagca gtgaagagat aaagaaaaaa 2100 aagtacaacc aaatgccagt caggcacagc agaaacctac aactcatgga aggtaaagaa 2160 cctgcaactg gagccaagaa gagtaacaag ccaaatgaac agacaagtaa aagacatgac 2220 agcgatactt tcccagagct gaagttaaca aatgcacctg gttcttttac taagtgttca 2280 aataccagtg aacttaaaga atttgtcaat cctagccttc caagagaaga aaaagaagag 2340 aaactagaaa cagttaaagt gtctaataat gctgaagacc ccaaagatct catgttaagt 2400 ggagaaaggg ttttgcaaac tgaaagatct gtagagagta gcagtatttc attggtacct 2460 ggtactgatt atggcactca ggaaagtatc tcgttactgg aagttagcac tctagggaag 2520 gcaaaaacag aaccaaataa atgtgtgagt cagtgtgcag catttgaaaa ccccaaggga 2580 ctaattcatg gttgttccaa agataataga aatgacacag aaggctttaa gtatccattg 2640 ggacatgaag ttaaccacag tcgggaaaca agcatagaaa tggaagaaag tgaacttgat 2700 gctcagtatt tgcagaatac attcaaggtt tcaaagcgcc agtcatttgc tccgttttca 2760 aatccaggaa atgcagaaga ggaatgtgca acattctctg cccactctgg gtccttaaag 2820 aaacaaagtc caaaagtcac ttttgaatgt gaacaaaagg aagaaaatca aggaaagaat 2880 gagtctaata tcaagcctgt acagacagtt aatatcactg caggctttcc tgtggttggt 2940 cagaaagata agccagttga taatgccaaa tgtagtatca aaggaggctc taggttttgt 3000 ctatcatctc agttcagagg caacgaaact ggactcatta ctccaaataa acatggactt 3060 ttacaaaacc catatcgtat accaccactt tttcccatca agtcatttgt taaaactaaa 3120 tgtaagaaaa atctgctaga ggaaaacttt gaggaacatt caatgtcacc tgaaagagaa 3180 atgggaaatg agaacattcc aagtacagtg agcacaatta gccgtaataa cattagagaa 3240 aatgttttta aagaagccag ctcaagcaat attaatgaag taggttccag tactaatgaa 3300 gtgggctcca gtattaatga aataggttcc agtgatgaaa acattcaagc agaactaggt 3360 agaaacagag ggccaaaatt gaatgctatg cttagattag gggttttgca acctgaggtc 3420 tataaacaaa gtcttcctgg aagtaattgt aagcatcctg aaataaaaaa gcaagaatat 3480 gaagaagtag ttcagactgt taatacagat ttctctccat atctgatttc agataactta 3540 gaacagccta tgggaagtag tcatgcatct caggtttgtt ctgagacacc tgatgacctg 3600 ttagatgatg gtgaaataaa ggaagatact agttttgctg aaaatgacat taaggaaagt 3660 tctgctgttt ttagcaaaag cgtccagaaa ggagagctta gcaggagtcc tagccctttc 3720 acccatacac atttggctca gggttaccga agaggggcca agaaattaga gtcctcagaa 3780 gagaacttat ctagtgagga tgaagagctt ccctgcttcc aacacttgtt atttggtaaa 3840 gtaaacaata taccttctca gtctactagg catagcaccg ttgctaccga gtgtctgtct 3900 aagaacacag aggagaattt attatcattg aagaatagct taaatgactg cagtaaccag 3960 gtaatattgg caaaggcatc tcaggaacat caccttagtg aggaaacaaa atgttctgct 4020 agcttgtttt cttcacagtg cagtgaattg gaagacttga ctgcaaatac aaacacccag 4080 gatcctttct tgattggttc ttccaaacaa atgaggcatc agtctgaaag ccagggagtt 4140 ggtctgagtg acaaggaatt ggtttcagat gatgaagaaa gaggaacggg cttggaagaa 4200 aataatcaag aagagcaaag catggattca aacttaggtg aagcagcatc tgggtgtgag 4260 agtgaaacaa gcgtctctga agactgctca gggctatcct ctcagagtga cattttaacc 4320 actcagcaga gggataccat gcaacataac ctgataaagc tccagcagga aatggctgaa 4380 ctagaagctg tgttagaaca gcatgggagc cagccttcta acagctaccc ttccatcata 4440 agtgactctt ctgcccttga ggacctgcga aatccagaac aaagcacatc agaaaaagca 4500 gtattaactt cacagaaaag tagtgaatac cctataagcc agaatccaga aggcctttct 4560 gctgacaagt ttgaggtgtc tgcagatagt tctaccagta aaaataaaga accaggagtg 4620 gaaagatgct gagtttgtgt gtgaacggac actgaaatat tttctaggaa ttgcgggagg 4680 aaaatgggta gttagctatt tctgggtgac ccagtctatt aaagaaagaa aaatgctgaa 4740 tgagcatgat tttgaagtca gaggagatgt ggtcaatgga agaaaccacc aaggtccaaa 4800 gcgagcaaga gaatcccagg acagaaagat cttcaggggg ctagaaatct gttgctatgg 4860 gcccttcacc aacatgccca cagatcaact ggaatggatg gtacagctgt gtggtgcttc 4920 tgtggtgaag gagctttcat cattcaccct tggcacaggt gtccacccaa ttgtggttgt 4980 gcagccagat gcctggacag aggacaatgg cttccatgca attgggcaga tgtgtgaggc 5040 acctgtggtg acccgagagt gggtgttgga cagtgtagca ctctaccagt gccaggagct 5100 ggacacctac ctgatacccc agatccccca cagccactac tgactgcagc cagccacagg 5160 tacagagcca caggacccca agaatgagct tacaaagtgg cctttccagg ccctgggagc 5220 tcctctcact cttcagtcct tctactgtcc tggctactaa atattttatg tacatcagcc 5280 tgaaaaggac ttctggctat gcaagggtcc cttaaagatt ttctgcttga agtctccctt 5340 ggaaatctgc catgagcaca aaattatggt aatttttcac ctgagaagat tttaaaacca 5400 tttaaacgcc accaattgag caagatgctg attcattatt tatcagccct attctttcta 5460 ttcaggctgt tgttggctta gggctggaag cacagagtgg cttggcctca agagaatagc 5520 tggtttccct aagtttactt ctctaaaacc ctgtgttcac aaaggcagag agtcagaccc 5580 ttcaatggaa ggagagtgct tgggatcgat tatgtgactt aaagtcagaa tagtccttgg 5640 gcagttctca aatgttggag tggaacattg gggaggaaat tctgaggcag gtattagaaa 5700 tgaaaaggaa acttgaaacc tgggcatggt ggctcacgcc tgtaatccca gcactttggg 5760 aggccaaggt gggcagatca ctggaggtca ggagttcgaa accagcctgg ccaacatggt 5820 gaaaccccat ctctactaaa aatacagaaa ttagccggtc atggtggtgg acacctgtaa 5880 tcccagctac tcaggtggct aaggcaggag aatcacttca gcccgggagg tggaggttgc 5940 agtgagccaa gatcatacca cggcactcca gcctgggtga cagtgagact gtggctcaaa 6000 aaaaaaaaaa aaaaaggaaa atgaaactag gaaaggtttc ttaaagtctg agatatattt 6060 gctagatttc taaagaatgt gttctaaaac agcagaagat tttcaagaac cggtttccaa 6120 agacagtctt ctaattcctc attagtaata agtaaaatgt ttattgttgt agctctggta 6180 tataatccat tcctcttaaa atataagacc tctggcatga atatttcata tctataaaat 6240 gacagatccc accaggaagg aagctgttgc tttctttgag gtgatttttt tcctttgctc 6300 cctgttgctg aaaccataca gcttcataaa taattttgct tgctgaagga agaaaaagtg 6360 tttttcataa acccattatc caggactgtt tatagctgtt ggaaggacta ggtcttccct 6420 agccccccca gtgtgcaagg gcagtgaaga cttgattgta caaaatacgt tttgtaaatg 6480 ttgtgctgtt aacactgcaa ataaacttgg tagcaaaca 6519 <210> 577 <211> 6313 <212> DNA <213> Homo sapiens <400> 577 aaaactgcga ctgcgcggcg tgagctcgct gagacttcct ggaccccgca ccaggctgtg 60 gggtttctca gataactggg cccctgcgct caggaggcct tcaccctctg ctctgggtaa 120 agttcattgg aacagaaaga aatggattta tctgctcttc gcgttgaaga agtacaaaat 180 gtcattaatg ctatgcagaa aatcttagag tgtcccatct gtctggagtt gatcaaggaa 240 cctgtctcca caaagtgtga ccacatattt tgcaaatttt gcatgctgaa acttctcaac 300 cagaagaaag ggccttcaca gtgtccttta tgtaagaatg atataaccaa aaggagccta 360 caagaaagta cgagatttag tcaacttgtt gaagagctat tgaaaatcat ttgtgctttt 420 cagcttgaca caggtttgga gtatgcaaac agctataatt ttgcaaaaaa ggaaaataac 480 tctcctgaac atctaaaaga tgaagtttct atcatccaaa gtatgggcta cagaaaccgt 540 gccaaaagac ttctacagag tgaacccgaa aatccttcct tgcaggaaac cagtctcagt 600 gtccaactct ctaaccttgg aactgtgaga actctgagga caaagcagcg gatacaacct 660 caaaagacgt ctgtctacat tgaattggga tctgattctt ctgaagatac cgttaataag 720 gcaacttatt gcagtgtggg agatcaagaa ttgttacaaa tcacccctca aggaaccagg 780 gatgaaatca gtttggattc tgcaaaaaag gctgcttgtg aattttctga gacggatgta 840 acaaatactg aacatcatca acccagtaat aatgatttga acaccactga gaagcgtgca 900 gctgagaggc atccagaaaa gtatcagggt agttctgttt caaacttgca tgtggagcca 960 tgtggcacaa atactcatgc cagctcatta cagcatgaga acagcagttt attactcact 1020 aaagacagaa tgaatgtaga aaaggctgaa ttctgtaata aaagcaaaca gcctggctta 1080 gcaaggagcc aacataacag atgggctgga agtaaggaaa catgtaatga taggcggact 1140 cccagcacag aaaaaaaggt agatctgaat gctgatcccc tgtgtgagag aaaagaatgg 1200 aataagcaga aactgccatg ctcagagaat cctagagata ctgaagatgt tccttggata 1260 acactaaata gcagcattca gaaagttaat gagtggtttt ccagaagtga tgaactgtta 1320 ggttctgatg actcacatga tggggagtct gaatcaaatg ccaaagtagc tgatgtattg 1380 gacgttctaa atgaggtaga tgaatattct ggttcttcag agaaaataga cttactggcc 1440 agtgatcctc atgaggcttt aatatgtaaa agtgaaagag ttcactccaa atcagtagag 1500 agtaatattg aagacaaaat atttgggaaa acctatcgga agaaggcaag cctccccaac 1560 ttaagccatg taactgaaaa tctaattata ggagcatttg ttactgagcc acagataata 1620 caagagcgtc ccctcacaaa taaattaaag cgtaaaagga gacctacatc aggccttcat 1680 cctgaggatt ttatcaagaa agcagatttg gcagttcaaa agactcctga aatgataaat 1740 cagggaacta accaaacgga gcagaatggt caagtgatga atattactaa tagtggtcat 1800 gagaataaaa caaaaggtga ttctattcag aatgagaaaa atcctaaccc aatagaatca 1860 ctcgaaaaag aatctgcttt caaaacgaaa gctgaaccta taagcagcag tataagcaat 1920 atggaactcg aattaaatat ccacaattca aaagcaccta aaaagaatag gctgaggagg 1980 aagtcttcta ccaggcatat tcatgcgctt gaactagtag tcagtagaaa tctaagccca 2040 cctaattgta ctgaattgca aattgatagt tgttctagca gtgaagagat aaagaaaaaa 2100 aagtacaacc aaatgccagt caggcacagc agaaacctac aactcatgga aggtaaagaa 2160 cctgcaactg gagccaagaa gagtaacaag ccaaatgaac agacaagtaa aagacatgac 2220 agcgatactt tcccagagct gaagttaaca aatgcacctg gttcttttac taagtgttca 2280 aataccagtg aacttaaaga atttgtcaat cctagccttc caagagaaga aaaagaagag 2340 aaactagaaa cagttaaagt gtctaataat gctgaagacc ccaaagatct catgttaagt 2400 ggagaaaggg ttttgcaaac tgaaagatct gtagagagta gcagtatttc attggtacct 2460 ggtactgatt atggcactca ggaaagtatc tcgttactgg aagttagcac tctagggaag 2520 gcaaaaacag aaccaaataa atgtgtgagt cagtgtgcag catttgaaaa ccccaaggga 2580 ctaattcatg gttgttccaa agataataga aatgacacag aaggctttaa gtatccattg 2640 ggacatgaag ttaaccacag tcgggaaaca agcatagaaa tggaagaaag tgaacttgat 2700 gctcagtatt tgcagaatac attcaaggtt tcaaagcgcc agtcatttgc tccgttttca 2760 aatccaggaa atgcagaaga ggaatgtgca acattctctg cccactctgg gtccttaaag 2820 aaacaaagtc caaaagtcac ttttgaatgt gaacaaaagg aagaaaatca aggaaagaat 2880 gagtctaata tcaagcctgt acagacagtt aatatcactg caggctttcc tgtggttggt 2940 cagaaagata agccagttga taatgccaaa tgtagtatca aaggaggctc taggttttgt 3000 ctatcatctc agttcagagg caacgaaact ggactcatta ctccaaataa acatggactt 3060 ttacaaaacc catatcgtat accaccactt tttcccatca agtcatttgt taaaactaaa 3120 tgtaagaaaa atctgctaga ggaaaacttt gaggaacatt caatgtcacc tgaaagagaa 3180 atgggaaatg agaacattcc aagtacagtg agcacaatta gccgtaataa cattagagaa 3240 aatgttttta aagaagccag ctcaagcaat attaatgaag taggttccag tactaatgaa 3300 gtgggctcca gtattaatga aataggttcc agtgatgaaa acattcaagc agaactaggt 3360 agaaacagag ggccaaaatt gaatgctatg cttagattag gggttttgca acctgaggtc 3420 tataaacaaa gtcttcctgg aagtaattgt aagcatcctg aaataaaaaa gcaagaatat 3480 gaagaagtag ttcagactgt taatacagat ttctctccat atctgatttc agataactta 3540 gaacagccta tgggaagtag tcatgcatct caggtttgtt ctgagacacc tgatgacctg 3600 ttagatgatg gtgaaataaa ggaagatact agttttgctg aaaatgacat taaggaaagt 3660 tctgctgttt ttagcaaaag cgtccagaaa ggagagctta gcaggagtcc tagccctttc 3720 acccatacac atttggctca gggttaccga agaggggcca agaaattaga gtcctcagaa 3780 gagaacttat ctagtgagga tgaagagctt ccctgcttcc aacacttgtt atttggtaaa 3840 gtaaacaata taccttctca gtctactagg catagcaccg ttgctaccga gtgtctgtct 3900 aagaacacag aggagaattt attatcattg aagaatagct taaatgactg cagtaaccag 3960 gtaatattgg caaaggcatc tcaggaacat caccttagtg aggaaacaaa atgttctgct 4020 agcttgtttt cttcacagtg cagtgaattg gaagacttga ctgcaaatac aaacacccag 4080 gatcctttct tgattggttc ttccaaacaa atgaggcatc agtctgaaag ccagggagtt 4140 ggtctgagtg acaaggaatt ggtttcagat gatgaagaaa gaggaacggg cttggaagaa 4200 aataatcaag aagagcaaag catggattca aacttaggtg aagcagcatc tgggtgtgag 4260 agtgaaacaa gcgtctctga agactgctca gggctatcct ctcagagtga cattttaacc 4320 actcagcaga gggataccat gcaacataac ctgataaagc tccagcagga aatggctgaa 4380 ctagaagctg tgttagaaca gcatgggagc cagccttcta acagctaccc ttccatcata 4440 agtgactctt ctgcccttga ggacctgcga aatccagaac aaagcacatc agaaaaaggg 4500 gtgacccagt ctattaaaga aagaaaaatg ctgaatgagc atgattttga agtcagagga 4560 gatgtggtca atggaagaaa ccaccaaggt ccaaagcgag caagagaatc ccaggacaga 4620 aagatcttca gggggctaga aatctgttgc tatgggccct tcaccaacat gcccacagat 4680 caactggaat ggatggtaca gctgtgtggt gcttctgtgg tgaaggagct ttcatcattc 4740 acccttggca caggtgtcca cccaattgtg gttgtgcagc cagatgcctg gacagaggac 4800 aatggcttcc atgcaattgg gcagatgtgt gaggcacctg tggtgacccg agagtgggtg 4860 ttggacagtg tagcactcta ccagtgccag gagctggaca cctacctgat accccagatc 4920 ccccacagcc actactgact gcagccagcc acaggtacaa gccacaggac cccaagaatg 4980 agcttacaaa gtggcctttc caggccctgg gagctcctct cactcttcag tccttctact 5040 gtcctggcta ctaaatattt tatgtacatc agcctgaaaa ggacttctgg ctatgcaagg 5100 gtcccttaaa gattttctgc ttgaagtctc ccttggaaat ctgccatgag cacaaaatta 5160 tggtaatttt tcacctgaga agattttaaa accatttaaa cgccaccaat tgagcaagat 5220 gctgattcat tatttatcag ccctattctt tctattcagg ctgttgttgg cttagggctg 5280 gaagcacaga gtggcttggc ctcaagagaa tagctggttt ccctaagttt acttctctaa 5340 aaccctgtgt tcacaaaggc agagagtcag acccttcaat ggaaggagag tgcttgggat 5400 cgattatgtg acttaaagtc agaatagtcc ttgggcagtt ctcaaatgtt ggagtggaac 5460 attggggagg aaattctgag gcaggtatta gaaatgaaaa ggaaacttga aacctgggca 5520 tggtggctca cgcctgtaat cccagcactt tgggaggcca aggtgggcag atcactggag 5580 gtcaggagtt cgaaaccagc ctggccaaca tggtgaaacc ccatctctac taaaaataca 5640 gaaattagcc ggtcatggtg gtggacacct gtaatcccag ctactcaggt ggctaaggca 5700 ggagaatcac ttcagcccgg gaggtggagg ttgcagtgag ccaagatcat accacggcac 5760 tccagcctgg gtgacagtga gactgtggct caaaaaaaaa aaaaaaaaag gaaaatgaaa 5820 ctaggaaagg tttcttaaag tctgagatat atttgctaga tttctaaaga atgtgttcta 5880 aaacagcaga agattttcaa gaaccggttt ccaaagacag tcttctaatt cctcattagt 5940 aataagtaaa atgtttattg ttgtagctct ggtatataat ccattcctct taaaatataa 6000 gacctctggc atgaatattt catatctata aaatgacaga tcccaccagg aaggaagctg 6060 ttgctttctt tgaggtgatt tttttccttt gctccctgtt gctgaaacca tacagcttca 6120 taaataattt tgcttgctga aggaagaaaa agtgtttttc ataaacccat tatccaggac 6180 tgtttatagc tgttggaagg actaggtctt ccctagcccc cccagtgtgc aagggcagtg 6240 aagacttgat tgtacaaaat acgttttgta aatgttgtgc tgttaacact gcaaataaac 6300 ttggtagcaa aca 6313 <210> 578 <211> 6391 <212> DNA <213> Homo sapiens <400> 578 aaaactgcga ctgcgcggcg tgagctcgct gagacttcct ggaccccgca ccaggctgtg 60 gggtttctca gataactggg cccctgcgct caggaggcct tcaccctctg ctctgggtaa 120 agttcattgg aacagaaaga aatggattta tctgctcttc gcgttgaaga agtacaaaat 180 gtcattaatg ctatgcagaa aatcttagag tgtcccatct gtctggagtt gatcaaggaa 240 cctgtctcca caaagtgtga ccacatattt tgcaaatttt gcatgctgaa acttctcaac 300 cagaagaaag ggccttcaca gtgtccttta tgtaagaatg atataaccaa aaggagccta 360 caagaaagta cgagatttag tcaacttgtt gaagagctat tgaaaatcat ttgtgctttt 420 cagcttgaca caggtttgga gtatgcaaac agctataatt ttgcaaaaaa ggaaaataac 480 tctcctgaac atctaaaaga tgaagtttct atcatccaaa gtatgggcta cagaaaccgt 540 gccaaaagac ttctacagag tgaacccgaa aatccttcct tgcaggaaac cagtctcagt 600 gtccaactct ctaaccttgg aactgtgaga actctgagga caaagcagcg gatacaacct 660 caaaagacgt ctgtctacat tgaattggga tctgattctt ctgaagatac cgttaataag 720 gcaacttatt gcagtgtggg agatcaagaa ttgttacaaa tcacccctca aggaaccagg 780 gatgaaatca gtttggattc tgcaaaaaag gctgcttgtg aattttctga gacggatgta 840 acaaatactg aacatcatca acccagtaat aatgatttga acaccactga gaagcgtgca 900 gctgagaggc atccagaaaa gtatcagggt agttctgttt caaacttgca tgtggagcca 960 tgtggcacaa atactcatgc cagctcatta cagcatgaga acagcagttt attactcact 1020 aaagacagaa tgaatgtaga aaaggctgaa ttctgtaata aaagcaaaca gcctggctta 1080 gcaaggagcc aacataacag atgggctgga agtaaggaaa catgtaatga taggcggact 1140 cccagcacag aaaaaaaggt agatctgaat gctgatcccc tgtgtgagag aaaagaatgg 1200 aataagcaga aactgccatg ctcagagaat cctagagata ctgaagatgt tccttggata 1260 acactaaata gcagcattca gaaagttaat gagtggtttt ccagaagtga tgaactgtta 1320 ggttctgatg actcacatga tggggagtct gaatcaaatg ccaaagtagc tgatgtattg 1380 gacgttctaa atgaggtaga tgaatattct ggttcttcag agaaaataga cttactggcc 1440 agtgatcctc atgaggcttt aatatgtaaa agtgaaagag ttcactccaa atcagtagag 1500 agtaatattg aagacaaaat atttgggaaa acctatcgga agaaggcaag cctccccaac 1560 ttaagccatg taactgaaaa tctaattata ggagcatttg ttactgagcc acagataata 1620 caagagcgtc ccctcacaaa taaattaaag cgtaaaagga gacctacatc aggccttcat 1680 cctgaggatt ttatcaagaa agcagatttg gcagttcaaa agactcctga aatgataaat 1740 cagggaacta accaaacgga gcagaatggt caagtgatga atattactaa tagtggtcat 1800 gagaataaaa caaaaggtga ttctattcag aatgagaaaa atcctaaccc aatagaatca 1860 ctcgaaaaag aatctgcttt caaaacgaaa gctgaaccta taagcagcag tataagcaat 1920 atggaactcg aattaaatat ccacaattca aaagcaccta aaaagaatag gctgaggagg 1980 aagtcttcta ccaggcatat tcatgcgctt gaactagtag tcagtagaaa tctaagccca 2040 cctaattgta ctgaattgca aattgatagt tgttctagca gtgaagagat aaagaaaaaa 2100 aagtacaacc aaatgccagt caggcacagc agaaacctac aactcatgga aggtaaagaa 2160 cctgcaactg gagccaagaa gagtaacaag ccaaatgaac agacaagtaa aagacatgac 2220 agcgatactt tcccagagct gaagttaaca aatgcacctg gttcttttac taagtgttca 2280 aataccagtg aacttaaaga atttgtcaat cctagccttc caagagaaga aaaagaagag 2340 aaactagaaa cagttaaagt gtctaataat gctgaagacc ccaaagatct catgttaagt 2400 ggagaaaggg ttttgcaaac tgaaagatct gtagagagta gcagtatttc attggtacct 2460 ggtactgatt atggcactca ggaaagtatc tcgttactgg aagttagcac tctagggaag 2520 gcaaaaacag aaccaaataa atgtgtgagt cagtgtgcag catttgaaaa ccccaaggga 2580 ctaattcatg gttgttccaa agataataga aatgacacag aaggctttaa gtatccattg 2640 ggacatgaag ttaaccacag tcgggaaaca agcatagaaa tggaagaaag tgaacttgat 2700 gctcagtatt tgcagaatac attcaaggtt tcaaagcgcc agtcatttgc tccgttttca 2760 aatccaggaa atgcagaaga ggaatgtgca acattctctg cccactctgg gtccttaaag 2820 aaacaaagtc caaaagtcac ttttgaatgt gaacaaaagg aagaaaatca aggaaagaat 2880 gagtctaata tcaagcctgt acagacagtt aatatcactg caggctttcc tgtggttggt 2940 cagaaagata agccagttga taatgccaaa tgtagtatca aaggaggctc taggttttgt 3000 ctatcatctc agttcagagg caacgaaact ggactcatta ctccaaataa acatggactt 3060 ttacaaaacc catatcgtat accaccactt tttcccatca agtcatttgt taaaactaaa 3120 tgtaagaaaa atctgctaga ggaaaacttt gaggaacatt caatgtcacc tgaaagagaa 3180 atgggaaatg agaacattcc aagtacagtg agcacaatta gccgtaataa cattagagaa 3240 aatgttttta aagaagccag ctcaagcaat attaatgaag taggttccag tactaatgaa 3300 gtgggctcca gtattaatga aataggttcc agtgatgaaa acattcaagc agaactaggt 3360 agaaacagag ggccaaaatt gaatgctatg cttagattag gggttttgca acctgaggtc 3420 tataaacaaa gtcttcctgg aagtaattgt aagcatcctg aaataaaaaa gcaagaatat 3480 gaagaagtag ttcagactgt taatacagat ttctctccat atctgatttc agataactta 3540 gaacagccta tgggaagtag tcatgcatct caggtttgtt ctgagacacc tgatgacctg 3600 ttagatgatg gtgaaataaa ggaagatact agttttgctg aaaatgacat taaggaaagt 3660 tctgctgttt ttagcaaaag cgtccagaaa ggagagctta gcaggagtcc tagccctttc 3720 acccatacac atttggctca gggttaccga agaggggcca agaaattaga gtcctcagaa 3780 gagaacttat ctagtgagga tgaagagctt ccctgcttcc aacacttgtt atttggtaaa 3840 gtaaacaata taccttctca gtctactagg catagcaccg ttgctaccga gtgtctgtct 3900 aagaacacag aggagaattt attatcattg aagaatagct taaatgactg cagtaaccag 3960 gtaatattgg caaaggcatc tcaggaacat caccttagtg aggaaacaaa atgttctgct 4020 agcttgtttt cttcacagtg cagtgaattg gaagacttga ctgcaaatac aaacacccag 4080 gatcctttct tgattggttc ttccaaacaa atgaggcatc agtctgaaag ccagggagtt 4140 ggtctgagtg acaaggaatt ggtttcagat gatgaagaaa gaggaacggg cttggaagaa 4200 aataatcaag aagagcaaag catggattca aacttaggtg aagcagcatc tgggtgtgag 4260 agtgaaacaa gcgtctctga agactgctca gggctatcct ctcagagtga cattttaacc 4320 actcagcaga gggataccat gcaacataac ctgataaagc tccagcagga aatggctgaa 4380 ctagaagctg tgttagaaca gcatgggagc cagccttcta acagctaccc ttccatcata 4440 agtgactctt ctgcccttga ggacctgcga aatccagaac aaagcacatc agaaaaagat 4500 gctgagtttg tgtgtgaacg gacactgaaa tattttctag gaattgcggg aggaaaatgg 4560 gtagttagct atttctgggt gacccagtct attaaagaaa gaaaaatgct gaatgagcat 4620 gattttgaag tcagaggaga tgtggtcaat ggaagaaacc accaaggtcc aaagcgagca 4680 agagaatccc aggacagaaa gatcttcagg gggctagaaa tctgttgcta tgggcccttc 4740 accaacatgc ccacagatca actggaatgg atggtacagc tgtgtggtgc ttctgtggtg 4800 aaggagcttt catcattcac ccttggcaca ggtgtccacc caattgtggt tgtgcagcca 4860 gatgcctgga cagaggacaa tggcttccat gcaattgggc agatgtgtga ggcacctgtg 4920 gtgacccgag agtgggtgtt ggacagtgta gcactctacc agtgccagga gctggacacc 4980 tacctgatac cccagatccc ccacagccac tactgactgc agccagccac aggtacagac 5040 cacaggaccc caagaatgag cttacaaagt ggcctttcca ggccctggga gctcctctca 5100 ctcttcagtc cttctactgt cctggctact aaatatttta tgtacatcag cctgaaaagg 5160 acttctggct atgcaagggt cccttaaaga ttttctgctt gaagtctccc ttggaaatct 5220 gccatgagca caaaattatg gtaatttttc acctgagaag attttaaaac catttaaacg 5280 ccaccaattg agcaagatgc tgattcatta tttatcagcc ctattctttc tattcaggct 5340 gttgttggct tagggctgga agcacagagt ggcttggcct caagagaata gctggtttcc 5400 ctaagtttac ttctctaaaa ccctgtgttc acaaaggcag agagtcagac ccttcaatgg 5460 aaggagagtg cttgggatcg attatgtgac ttaaagtcag aatagtcctt gggcagttct 5520 caaatgttgg agtggaacat tggggaggaa attctgaggc aggtattaga aatgaaaagg 5580 aaacttgaaa cctgggcatg gtggctcacg cctgtaatcc cagcactttg ggaggccaag 5640 gtgggcagat cactggaggt caggagttcg aaaccagcct ggccaacatg gtgaaacccc 5700 atctctacta aaaatacaga aattagccgg tcatggtggt ggacacctgt aatcccagct 5760 actcaggtgg ctaaggcagg agaatcactt cagcccggga ggtggaggtt gcagtgagcc 5820 aagatcatac cacggcactc cagcctgggt gacagtgaga ctgtggctca aaaaaaaaaa 5880 aaaaaaagga aaatgaaact aggaaaggtt tcttaaagtc tgagatatat ttgctagatt 5940 tctaaagaat gtgttctaaa acagcagaag attttcaaga accggtttcc aaagacagtc 6000 ttctaattcc tcattagtaa taagtaaaat gtttattgtt gtagctctgg tatataatcc 6060 attcctctta aaatataaga cctctggcat gaatatttca tatctataaa atgacagatc 6120 ccaccaggaa ggaagctgtt gctttctttg aggtgatttt tttcctttgc tccctgttgc 6180 tgaaaccata cagcttcata aataattttg cttgctgaag gaagaaaaag tgtttttcat 6240 aaacccatta tccaggactg tttatagctg ttggaaggac taggtcttcc ctagcccccc 6300 cagtgtgcaa gggcagtgaa gacttgattg tacaaaatac gttttgtaaa tgttgtgctg 6360 ttaacactgc aaataaactt ggtagcaaac a 6391 <210> 579 <211> 3310 <212> DNA <213> Homo sapiens <400> 579 ggcgggcgac caaagcgcct gaggaccggc aacatggtgc ggtcggggaa taaggcagct 60 gttgtgctgt gtatggacgt gggctttacc atgagtaact ccattcctgg tatagaatcc 120 ccatttgaac aagcaaagaa ggtgataacc atgtttgtac agcgacaggt gtttgctgag 180 aacaaggatg agattgcttt agtcctgttt ggtacagatg gcactgacaa tcccctttct 240 ggtggggatc agtatcagaa catcacagtg cacagacatc tgatgctacc agattttgat 300 ttgctggagg acattgaaag caaaatccaa ccaggttctc aacaggctga cttcctggat 360 gcactaatcg tgagcatgga tgtgattcaa catgaaacaa taggaaagaa gtttgagaag 420 aggcatattg aaatattcac tgacctcagc agccgattca gcaaaagtca gctggatatt 480 ataattcata gcttgaagaa atgtgacatc tccctgcaat tcttcttgcc tttctcactt 540 ggcaaggaag atggaagtgg ggacagagga gatggcccct ttcgcttagg tggccatggg 600 ccttcctttc cactaaaagg aattaccgaa cagcaaaaag aaggtcttga gatagtgaaa 660 atggtgatga tatctttaga aggtgaagat gggttggatg aaatttattc attcagtgag 720 agtctgagaa aactgtgcgt cttcaagaaa attgagaggc attccattca ctggccctgc 780 cgactgacca ttggctccaa tttgtctata aggattgcag cctataaatc gattctacag 840 gagagagtta aaaagacttg gacagttgtg gatgcaaaaa ccctaaaaaa agaagatata 900 caaaaagaaa cagtttattg cttaaatgat gatgatgaaa ctgaagtttt aaaagaggat 960 attattcaag ggttccgcta tggaagtgat atagttcctt tctctaaagt ggatgaggaa 1020 caaatgaaat ataaatcgga ggggaagtgc ttctctgttt tgggattttg taaatcttct 1080 caggttcaga gaagattctt catgggaaat caagttctaa aggtctttgc agcaagagat 1140 gatgaggcag ctgcagttgc actttcctcc ctgattcatg ctttggatga cttagacatg 1200 gtggccatag ttcgatatgc ttatgacaaa agagctaatc ctcaagtcgg cgtggctttt 1260 cctcatatca agcataacta tgagtgttta gtgtatgtgc agctgccttt catggaagac 1320 ttgcggcaat acatgttttc atccttgaaa aacagtaaga aatatgctcc caccgaggca 1380 cagttgaatg ctgttgatgc tttgattgac tccatgagct tggcaaagaa agatgagaag 1440 acagacaccc ttgaagactt gtttccaacc accaaaatcc caaatcctcg atttcagaga 1500 ttatttcagt gtctgctgca cagagcttta catccccggg agcctctacc cccaattcag 1560 cagcatattt ggaatatgct gaatcctccc gctgaggtga caacaaaaag tcagattcct 1620 ctctctaaaa taaagaccct ttttcctctg attgaagcca agaaaaagga tcaagtgact 1680 gctcaggaaa ttttccaaga caaccatgaa gatggaccta cagctaaaaa attaaagact 1740 gagcaagggg gagcccactt cagcgtctcc agtctggctg aaggcagtgt cacctctgtt 1800 ggaagtgtga atcctgctga aaacttccgt gttctagtga aacagaagaa ggccagcttt 1860 gaggaagcga gtaaccagct cataaatcac atcgaacagt ttttggatac taatgaaaca 1920 ccgtatttta tgaagagcat agactgcatc cgagccttcc gggaagaagc cattaagttt 1980 tcagaagagc agcgctttaa caacttcctg aaagcccttc aagagaaagt ggaaattaaa 2040 caattaaatc atttctggga aattgttgtc caggatggaa ttactctgat caccaaagag 2100 gaagcctctg gaagttctgt cacagctgag gaagccaaaa agtttctggc ccccaaagac 2160 aaaccaagtg gagacacagc agctgtattt gaagaaggtg gtgatgtgga cgatttattg 2220 gacatgatat aggtcgtgga tgtatgggga atctaagaga gctgccatcg ctgtgatgct 2280 gggagttcta acaaaacaag ttggatgcgg ccattcaagg ggagccaaaa tctcaagaaa 2340 ttcccagcag gttacctgga ggcggatcat ctaattctct gtggaatgaa tacacacata 2400 tatattacaa gggataattt agaccccata caagtttata aagagtcatt gttattttct 2460 ggttggtgta ttattttttc tgtggtctta ctgatctttg tatattacat acatgctttg 2520 aagtttctgg aaagtagatc ttttcttgac ctagtatatc agtgacagtt gcagcccttg 2580 tgatgtgatt agtgtctcat gtggaaccat ggcatggtta ttgatgagtt tcttaaccct 2640 ttccagagtc ctcctttgcc tgatcctcca acagctgtca caacttgtgt tgagcaagca 2700 gtagcatttg cttcctccca acaagcagct gggttaggaa aaccatgggt aaggacggac 2760 tcacttctct ttttagttga ggccttctag ttaccacatt actctgcctc tgtatatagg 2820 tggttttctt taagtggggt gggaagggga gcacaatttc ccttcatact ccttttaagc 2880 agtgagttat ggtggtggtc tcatgaagaa aagacctttt ggcccaatct ctgccatatc 2940 agtgaacctt tagaaactca aaaactgaga aatttacttc agtagttaga attatatcac 3000 ttcactgttc tctacttgca agcctcaaag agagaaagtt tcgttatatt aaaacactta 3060 ggtaactttt cggtctttcc catttctacc taagtcagct ttcatctttg tggatggtgt 3120 ctcctttact aaataagaaa ataacaaagc ccttattctc tttttttctt gtcctcattc 3180 ttgccttgag ttccagttcc tctttggtgt acagacttct tggtacccag tcacctctgt 3240 cttcagcacc ctcataagtc gtcactaata cacagttttg tacatgtaac attaaaggca 3300 taaatgactc 3310 <210> 580 <211> 3304 <212> DNA <213> Homo sapiens <400> 580 cgaccaaagc gcctgaggac cggcaacatg gtgcggtcgg ggaataaggc agctgttgtg 60 ctgtgtatgg acgtgggctt taccatgagt aactccattc ctggtataga atccccattt 120 gaacaagcaa agaaggtgat aaccatgttt gtacagcgac aggtgtttgc tgagaacaag 180 gatgagattg ctttagtcct gtttggtaca gatggcactg acaatcccct ttctggtggg 240 gatcagtatc agaacatcac agtgcacaga catctgatgc taccagattt tgatttgctg 300 gaggacattg aaagcaaaat ccaaccaggt tctcaacagg ctgacttcct ggatgcacta 360 atcgtgagca tggatgtgat tcaacatgaa acaataggaa agaagtttga gaagaggcat 420 attgaaatat tcactgacct cagcagccga ttcagcaaaa gtcagctgga tattataatt 480 catagcttga agaaatgtga catctccctg caattcttct tgcctttctc acttggcaag 540 gaagatggaa gtggggacag aggagatggc ccctttcgct taggtggcca tgggccttcc 600 tttccactaa aaggaattac cgaacagcaa aaagaaggtc ttgagatagt gaaaatggtg 660 atgatatctt tagaaggtga agatgggttg gatgaaattt attcattcag tgagagtctg 720 agaaaactgt gcgtcttcaa gaaaattgag aggcattcca ttcactggcc ctgccgactg 780 accattggct ccaatttgtc tataaggatt gcagcctata aatcgattct acaggagaga 840 gttaaaaaga cttggacagt tgtggatgca aaaaccctaa aaaaagaaga tatacaaaaa 900 gaaacagttt attgcttaaa tgatgatgat gaaactgaag ttttaaaaga ggatattatt 960 caagggttcc gctatggaag tgatatagtt cctttctcta aagtggatga ggaacaaatg 1020 aaatataaat cggaggggaa gtgcttctct gttttgggat tttgtaaatc ttctcaggtt 1080 cagagaagat tcttcatggg aaatcaagtt ctaaaggtct ttgcagcaag agatgatgag 1140 gcagctgcag ttgcactttc ctccctgatt catgctttgg atgacttaga catggtggcc 1200 atagttcgat atgcttatga caaaagagct aatcctcaag tcggcgtggc ttttcctcat 1260 atcaagcata actatgagtg tttagtgtat gtgcagctgc ctttcatgga agacttgcgg 1320 caatacatgt tttcatcctt gaaaaacagt aagaaatatg ctcccaccga ggcacagttg 1380 aatgctgttg atgctttgat tgactccatg agcttggcaa agaaagatga gaagacagac 1440 acccttgaag acttgtttcc aaccaccaaa atcccaaatc ctcgatttca gagattattt 1500 cagtgtctgc tgcacagagc tttacatccc cgggagcctc tacccccaat tcagcagcat 1560 atttggaata tgctgaatcc tcccgctgag gtgacaacaa aaagtcagat tcctctctct 1620 aaaataaaga ccctttttcc tctgattgaa gccaagaaaa aggatcaagt gactgctcag 1680 gaaattttcc aagacaacca tgaagatgga cctacagcta aaaaattaaa gactgagcaa 1740 gggggagccc acttcagcgt ctccagtctg gctgaaggca gtgtcacctc tgttggaagt 1800 gtgaatcctg ctgaaaactt ccgtgttcta gtgaaacaga agaaggccag ctttgaggaa 1860 gcgagtaacc agctcataaa tcacatcgaa cagtttttgg atactaatga aacaccgtat 1920 tttatgaaga gcatagactg catccgagcc ttccgggaag aagccattaa gttttcagaa 1980 gagcagcgct ttaacaactt cctgaaagcc cttcaagaga aagtggaaat taaacaatta 2040 aatcatttct gggaaattgt tgtccaggat ggaattactc tgatcaccaa agaggaagcc 2100 tctggaagtt ctgtcacagc tgaggaagcc aaaaagtttc tggcccccaa agacaaacca 2160 agtggagaca cagcagctgt atttgaagaa ggtggtgatg tggacgattt attggacatg 2220 atataggtcg tggatgtatg gggaatctaa gagagctgcc atcgctgtga tgctgggagt 2280 tctaacaaaa caagttggat gcggccattc aaggggagcc aaaatctcaa gaaattccca 2340 gcaggttacc tggaggcgga tcatctaatt ctctgtggaa tgaatacaca catatatatt 2400 acaagggata atttagaccc catacaagtt tataaagagt cattgttatt ttctggttgg 2460 tgtattattt tttctgtggt cttactgatc tttgtatatt acatacatgc tttgaagttt 2520 ctggaaagta gatcttttct tgacctagta tatcagtgac agttgcagcc cttgtgatgt 2580 gattagtgtc tcatgtggaa ccatggcatg gttattgatg agtttcttaa ccctttccag 2640 agtcctcctt tgcctgatcc tccaacagct gtcacaactt gtgttgagca agcagtagca 2700 tttgcttcct cccaacaagc agctgggtta ggaaaaccat gggtaaggac ggactcactt 2760 ctctttttag ttgaggcctt ctagttacca cattactctg cctctgtata taggtggttt 2820 tctttaagtg gggtgggaag gggagcacaa tttcccttca tactcctttt aagcagtgag 2880 ttatggtggt ggtctcatga agaaaagacc ttttggccca atctctgcca tatcagtgaa 2940 cctttagaaa ctcaaaaact gagaaattta cttcagtagt tagaattata tcacttcact 3000 gttctctact tgcaagcctc aaagagagaa agtttcgtta tattaaaaca cttaggtaac 3060 ttttcggtct ttcccatttc tacctaagtc agctttcatc tttgtggatg gtgtctcctt 3120 tactaaataa gaaaataaca aagcccttat tctctttttt tcttgtcctc attcttgcct 3180 tgagttccag ttcctctttg gtgtacagac ttcttggtac ccagtcacct ctgtcttcag 3240 caccctcata agtcgtcact aatacacagt tttgtacatg taacattaaa ggcataaatg 3300 actc 3304 <210> 581 <211> 2456 <212> DNA <213> Homo sapiens <400> 581 ggcacgaggc cggcaacatg gtgcggtcgg ggaataaggc agctgttgtg ctgtgtatgg 60 acgtgggctt taccatgagt aactccattc ctggtataga atccccattt gaacaagcaa 120 agaaggtgat aaccatgttt gtacagcgac aggtgtttgc tgagaacaag gatgagattg 180 ctttagtcct gtttggtaca gatggcactg acaatcccct ttctggtggg gatcagtatc 240 agaacatcac agtgcacaga catctgatgc taccagattt tgatttgctg gaggacattg 300 aaagcaaaat ccaaccaggt tctcaacagg ctgacttcct ggatgcacta atcgtgagca 360 tggatgtgat tcaacatgaa acaataggaa agaagtttga gaagaggcat attgaaatat 420 tcactgacct cagcagccga ttcagcaaaa gtcagctgga tattataatt catagcttga 480 agaaatgtga catctccctg caattcttct tgcctttctc acttggcaag gaagatggaa 540 gtggggacag aggagatggc ccctttcgct taggtggcca tgggccttcc tttccactaa 600 aaggaattac cgaacagcaa aaagaaggtc ttgagatagt gaaaatggtg atgatatctt 660 tagaaggtga agatgggttg gatgaaattt attcattcag tgagagtctg agaaaactgt 720 gcgtcttcaa gaaaattgag aggcattcca ttcactggcc ctgccgactg accattggct 780 ccaatttgtc tataaggatt gcagcctata aatcgattct acaggagaga gttaaaaaga 840 cttggacagt tgtggatgca aaaaccctaa aaaaagaaga tatacaaaaa gaaacagttt 900 attgcttaaa tgatgatgat gaaactgaag ttttaaaaga ggatattatt caagggttcc 960 gctatggaag tgatatagtt cctttctcta aagtggatga ggaacaaatg aaatataaat 1020 cggaggggaa gtgcttctct gttttgggat tttgtaaatc ttctcaggtt cagagaagat 1080 tcttcatggg aaatcaagtt ctaaaggtct ttgcagcaag agatgatgag gcagctgcag 1140 ttgcactttc ctccctgatt catgctttgg atgacttaga catggtggcc atagttcgat 1200 atgcttatga caaaagagct aatcctcaag tcggcgtggc ttttcctcat atcaagcata 1260 actatgagtg tttagtgtat gtgcagctgc ctttcatgga agacttgcgg caatacatgt 1320 tttcatcctt gaaaaacagt aagaaatatg ctcccaccga ggcacagttg aatgctgttg 1380 atgctttgat tgactccatg agcttggcaa agaaagatga gaagacagac acccttgaag 1440 acttgtttcc aaccaccaaa atcccaaatc ctcgatttca gagattattt cagtgtctgc 1500 tgcacagagc tttacatccc cgggagcctc tacccccaat tcagcagcat atttggaata 1560 tgctgaatcc tcccgctgag gtgacaacga aaagtcagat tcctctctct aaaataaaga 1620 ccctttttcc tctgattgaa gccaagaaaa aggatcaagt gactgctcag gaaattttcc 1680 aagacaacca tgaagatgga cctacagcta aaaaattaaa gactgagcaa gggggagccc 1740 acttcagcgt ctccagtctg gctgaaggca gtgtcacctc tgttggaagt gtgaatcctg 1800 ctgaaaactt ccgtgttcta gtgaaacaga agaaggccag ctttgaggaa gcgagtaacc 1860 agctcataaa tcacatcgaa cagtttttgg atactaatga aacaccgtat tttatgaaga 1920 gcatagactg catccgagcc ttccgggaag aagccattaa gttttcagaa gagcagcgct 1980 ttaacaactt cctgaaagcc cttcaagaga aagtggaaat taaacaatta aatcatttct 2040 gggaaattgt tgtccaggat ggaattactc tgatcaccaa agaggaagcc tctggaagtt 2100 ctgtcacagc tgaggaagcc aaaaagtttc tggcccccaa agacaaacca agtggagaca 2160 cagcagctgt atttgaagaa ggtggtgatg tggacgattt attggacatg atataggtcg 2220 tggatgtatg gggaatctaa gagagctgcc atcgctgtga tgctgggagt tctaacaaaa 2280 caagttggat gcggccattc aaggggagcc aaaatctcaa gaaattccca gcaggttacc 2340 tggaggcgga tcatctaatt ctctgtggaa tgaatacaca catatatatt acaagggata 2400 atttagaccc catacaagtt tataaagagt cattgttaaa aaaaaaaaaa aaaaaa 2456 <210> 582 <211> 3052 <212> DNA <213> Homo sapiens <400> 582 ggcgggcgac caaagcgcct gaggaccggc aacatggtgc ggtcggggaa taaggcagct 60 gttgtgctgt gtatggacgt gggctttacc atgagtaact ccattcctgg tatagaatcc 120 ccatttgaac aagcaaagaa ggtgataacc atgtttgtac agcgacaggt gtttgctgag 180 aacaaggatg agattgcttt agtcctgttt ggtacagatg gcactgacaa tcccctttct 240 ggtggggatc agtatcagaa catcacagtg cacagacatc tgatgctacc agattttgat 300 ttgctggagg acattgaaag caaaatccaa ccaggttctc aacaggctga cttcctggat 360 gcactaatcg tgagcatgga tgtgattcaa catgaaacaa taggaaagaa gtttgagaag 420 aggcatattg aaatattcac tgacctcagc agccgattca gcaaaagtca gctggatatt 480 ataattcata gcttgaagaa atgtgacatc tccctgcaat tcttcttgcc tttctcactt 540 ggcaaggaag atggaagtgg ggacagagga gatggcccct ttcgcttagg tggccatggg 600 ccttcctttc cactaaaagg aattaccgaa cagcaaaaag aaggtcttga gatagtgaaa 660 atggtgatga tatctttaga aggtgaagat gggttggatg aaatttattc attcagtgag 720 agtctgagaa aactgtgcgt cttcaagaaa attgagaggc attccattca ctggccctgc 780 cgactgacca ttggctccaa tttgtctata aggattgcag cctataaatc gattctacag 840 gagagagtta aaaagacttg gacagttgtg gatgcaaaaa ccctaaaaaa agaagatata 900 caaaaagaaa cagtttattg cttaaatgat gatgatgaaa ctgaagtttt aaaagaggat 960 attattcaag ggttccgcta tggaagtgat atagttcctt tctctaaagt ggatgaggaa 1020 caaatgaaat ataaatcgga ggggaagtgc ttctctgttt tgggattttg taaatcttct 1080 caggttcaga gaagattctt catgggaaat caagttctaa aggtctttgc agcaagagat 1140 gatgaggcag ctgcagttgc actttcctcc ctgattcatg ctttggatga cttagacatg 1200 gtggccatag ttcgatatgc ttatgacaaa agagctaatc ctcaagtcgg cgtggctttt 1260 cctcatatca agcataacta tgagtgttta gtgtatgtgc agctgccttt catggaagac 1320 ttgcggcaat acatgttttc atccttgaaa aacagtaaga aatatgctcc caccgaggca 1380 cagttgaatg ctgttgatgc tttgattgac tccatgagct tggcaaagaa agatgagaag 1440 acagacaccc ttgaagactt gtttccaacc accaaaatcc caaatcctcg atttcagaga 1500 ttatttcagt gtctgctgca cagagcttta catccccggg agcctctacc cccaattcag 1560 cagcatattt ggaatatgct gaatcctccc gctgaggtga caacgaaaag tcagattcct 1620 ctctctaaaa taaagaccct ttttcctctg attgaagcca agaaaaagga tcaagtgact 1680 gctcaggaaa ttttccaaga caaccatgaa gatggaccta cagctaaaaa attaaagact 1740 gagcaagggg gagcccactt cagcgtctcc agtctggctg aaggcagtgt cacctctgtt 1800 ggaagtgtga atcctgctga aaacttccgt gttctagtga aacagaagaa ggccagcttt 1860 gaggaagcga gtaaccagct cataaatcac atcgaacagt ttttggatac taatgaaaca 1920 ccgtatttta tgaagagcat agactgcatc cgagccttcc gggaagaagc cattaagttt 1980 tcagaagagc agcgctttaa caacttcctg aaagcccttc aagagaaagt ggaaattaaa 2040 caattaaatc atttctggga aattgttgtc caggatggaa ttactctgat caccaaagag 2100 gaagcctctg gaagttctgt cacagctgag gaagccaaaa agtttctggc ccccaaagac 2160 aaaccaagtg gagacacagc agctgtattt gaagaaggtg gtgatgtgga cgatttattg 2220 gacatgatat aggtcgtgga tgtatgggga atctaagaga gctgccatcg ctgtgatgct 2280 gggagttcta acaaaacaag ttggatgcgg ccattcaagg ggagccaaat tctcaagaaa 2340 ttcccagcag gttacctgga ggcggatcat ctaattctct gtggaatgaa tacacacata 2400 tatattacaa gggataattt agaccccata caagtttata aagagtcatt gttattttct 2460 ggttggtgta ttattttttc tgtggtctta ctgatctttg tatattacat acatgctttg 2520 aagtttctgg aaagtagatc ttttcttgac ctagtatatc agtgacagtt gcagcccttg 2580 tgatgtgatt agtgtctcat gtggaaccat ggcatggtta ttgatgagtt tcttaaccct 2640 ttccagagtc ctcctttgcc tgatcctcca acagctgtca cagcttgtgt tgagcaagca 2700 gtagcatttg cttcctccca acaagcagct gggttaggaa aaccatgggt aaggacggac 2760 tcacttctct ttttagttga ggccttctag ttaccacatt actctgcctc tgtatatagg 2820 tggttttctt taagtggggt gggaagggga gcacaatttc ccttcatact ccttttaagc 2880 agtgagttat ggtggtggtc tcatgaagaa aagacctttt ggcccaatct ctgccatatc 2940 agtgaacctt tagaaactca aaaactgaga aatttactac agtagttaga attatatcac 3000 ttcactgttc tctacttgca agcctcaaag agagaaagtt tcgttatatt gg 3052 <210> 583 <211> 2969 <212> DNA <213> Homo sapiens <400> 583 ggctgacttc ctggatgcac taatcgtgag catggatgtg attcaacatg aaacaatagg 60 aaagaagttt gagaagaggc atattgaaat attcactgac ctcagcagcc gattcagcaa 120 aagtcagctg gatattataa ttcatagctt gaagaaatgt gacatctccc tgcaattctt 180 cttgcctttc tcacttggca aggaagatgg aagtggggac agaggagatg gcccctttcg 240 cttaggtggc catgggcctt cctttccact aaaaggaatt accgaacagc aaaaagaagg 300 tcttgagata gtgaaaatgg tgatgatatc tttagaaggt gaagatgggt tggatgaaat 360 ttattcattc agtgagagtc tgagaaaact gtgcgtcttc aagaaaattg agaggcattc 420 cattcactgg ccctgccgac tgaccattgg ctccaatttg tctataagga ttgcagccta 480 taaatcgatt ctacaggaga gagttaaaaa gacttggaca gttgtggatg caaaaaccct 540 aaaaaaagaa gatatacaaa aagaaacagt ttattgctta aatgatgatg atgaaactga 600 agttttaaaa gaggatatta ttcaagggtt cctctatgga agtgatatag ttcctttctc 660 taaagtggat gaggaacaaa tgaaatataa atcggagggg aagtgcttct ctgttttggg 720 attttgtaaa tcttctcagg ttcagagaag attcttcatg ggaaatcaag ttctaaaggt 780 ctttgcagca agagatgatg aggcagctgc agttgcactt tcctccctga ttcatgcttt 840 ggatgactta gacatggtgg ccatagttcg atatgcttat gacaaaagag ctaatcctca 900 agtcggcgtg gcttttcctc atatcaagca taactatgag tgtttagtgt atgtgcagct 960 gcctttcatg gaagacttgc ggcaatacat gttttcatcc ttgaaaaaca gtaagaaata 1020 tgctcccacc gaggcacagt tgaatgctgt tgatgctttg attgactcca tgagcttggc 1080 aaagaaagat gagaagacag acacccttga agacttgttt ccaaccacca aaatcccaaa 1140 tcctcgattt cagagattat ttcagtgtct gctgcacaga gctttacatc cccgggagcc 1200 tctaccccca attcagcagc atatttggaa tatgctgaat cctcccgctg aggtgacaac 1260 gaaaagtcag attcctctct ctaaaataaa gacccttttt cctctgattg aagccaagaa 1320 aaaggatcaa gtgactgctc aggaaatttt ccaagacaac catgaagatg gacctacagc 1380 taaaaaatta aagactgagc aagggggagc ccacttcagc gtctccagtc tggctgaagg 1440 cagtgtcacc tctgttggaa gtgtgaatcc tgctgaaaac ttccgtgttc tagtgaaaca 1500 gaagaaggcc agctttgagg aagcgagtaa ccagctcata aatcacatcg aacagttttt 1560 ggatactaat gaaacaccgt attttatgaa gagcatagac tgcatccgag ccttccggga 1620 agaagccatt aagttttcag aagagcagcg ctttaacaac ttcctgaaag cccttcaaga 1680 gaaagtggaa attaaacaat taaatcattt ctgggaaatt gttgtccagg atggaattac 1740 tctgatcacc aaagaggaag cctctggaag ttctgtcaca gctgaggaag ccaaaaagtt 1800 tctggccccc aaagacaaac caagtggaga cacagcagct gtatttgaag aaggtggtga 1860 tgtggacgat ttattggaca tgatataggt cgtggatgta tggggaatct aagagagctg 1920 ccatcgctgt gatgctggga gttctaacaa aacaagttgg atgcggccat tcaaggggag 1980 ccaaaatctc aagaaattcc cagcaggtta cctgcaggcg gatcatctaa ttctctgtgg 2040 aatgaataca cacatatata ttacaaggga taatttagac cccatacaag tttataaaga 2100 gtcattgtta ttttctggtt ggtgtattat tttttctgtg gtcttactga tctttgtata 2160 ttacatacat gctttgaagt ttctggaaag tagatctttt cttgacctag tatatcagtg 2220 acagttgcag cccttgtgat gtgattagtg tctcatgtgg aaccatggca tggttattga 2280 tgagtttctt aaccctttcc agagtcctcc tttgcctgat cctccaacag ctgtcacaac 2340 ttgtgttgag caagcagtag catttgcttc ctcccaacaa gcagctgggt taggaaaacc 2400 atgggtaagg acggactcac ttctcttttt agttgaggcc ttctagttac cacattactc 2460 tgcctctgta tataggtggt tttctttaag tggggtggga aggggagcac aatttccctt 2520 catactcctt ttaagcagtg agttatggtg gtggtctcat gaagaaaaga ccttttggcc 2580 caatctctgc catatcagtg aacctttaga aactcaaaaa ctgagaaatt tactacagta 2640 gttagaatta tatcacttca ctgttctcta cttgcaagcc tcaaagagag aaagtttcgt 2700 tatattaaaa cacttaggta acttttcgat ctttcccatt tctacctaag tcagctttca 2760 tctttgtgga tggtgtctcc tttactaaat aagaaaataa caaagccctt attctctttt 2820 tttcttgtcc tcattcttgc cttgagttcc agttcctctt tggtgtacag acttcttggt 2880 acccagtcac ctctgtcttc agcaccctca taagtcgtca ctaatacaca gttttgtaca 2940 tgtaacatta aaggcataaa tgactcaaa 2969 <210> 584 <211> 1707 <212> DNA <213> Homo sapiens <400> 584 cgggatttag atcacgtccc gcaggccggc ggaagtagct gatactctca ttggttgcaa 60 aaccttgatc tgtgaaagcg ggcgttttgg aagataccgg aagtagagtc acggagaggt 120 aggatccgga agtggggctg cctctttaaa taacaaaaat ctgaggtatt aagaaatgga 180 gagaaaaata agcagaatcc accttgtttc tgaacccagt ataactcatt ttctacaagt 240 atcttgggag aaaacactgg aatctggttt tgttattaca cttactgatg gtcattcagc 300 atggactggg acagtttctg aatcagagat ttcccaagaa gctgatgaca tggcaatgga 360 aaaagggaaa tatgttggtg aactgagaaa agcattgttg tcaggagcag gaccagctga 420 tgtatacacg tttaattttt ctaaagagtc ttgttatttc ttctttgaga aaaacctgaa 480 agatgtctca ttcagacttg gttccttcaa cctagagaaa gttgaaaacc cagctgaagt 540 cattagagaa cttatttgtt attgcttgga caccattgca gaaaatcaag ccaaaaatga 600 gcacctgcag aaagaaaatg aaaggcttct gagagattgg aatgatgttc aaggacgatt 660 tgaaaaatgt gtgagtgcta aggaagcttt ggagactgat ctttataagc ggtttattct 720 ggtgttgaat gagaagaaaa caaaaatcag aagtttgcat aataaattat taaatgcagc 780 tcaagaacga gaaaaggaca tcaaacaaga aggggaaact gcaatctgtt ctgaaatgac 840 tgctgaccga gatccagtct atgatgagag tactgatgag gaaagtgaaa accaaactga 900 tctctctggg ttggcttcag ctgctgtaag taaagatgat tccattattt caagtcttga 960 tgtcactgat attgcaccaa gtagaaaaag gagacagcga atgcaaagaa atcttgggac 1020 agaacctaaa atggctcctc aggagaatca gcttcaagaa aaggaaaagc ctgattcttc 1080 actacctgag acgtcgaaaa aggagcacat ctcagctgaa aacatgtctt tagaaactct 1140 gagaaacagc agcccagaag acctctttga tgagatttaa cagtctcaaa aaatactttg 1200 atgttcacta gactatgttt tctattcatt tctttaaaat gaaaaaggag aatttcaagt 1260 cagcagccgc tattaccgta tcttacaatt taattacata cacagtgaat tgaaaccatt 1320 gtgcaaaatg gattacacat gtatacaaag atacgatttg atgatgacac tggcacattg 1380 agttctaaac tattcattca gcatgcctat aattacataa attgtatgag actttttgtt 1440 gcaaaggaca catttatcat attcattcac acatattata tgtgatagct gtccaacatc 1500 ctgtctggga agattttgaa aacaggacaa agaaaacatc attttaaaat gtcttcagct 1560 ttttttgaat agacgtattc aaacatattc tgaacattga tgtttgaaca ttttaatttg 1620 tgtgatgatg tagaaaatat aattttagtt tgtacataaa cattgtgaaa atctgataat 1680 aaaatttttg atacattgaa aaaaaaa 1707 <210> 585 <211> 1660 <212> DNA <213> Homo sapiens <400> 585 cgggatttag atcacgtccc gcaggccggc ggaagtagct gatactctca ttggttgcaa 60 aaccttgatc tgtgaaagcg ggcgttttgg aagataccgg aagtagagtc acggagaggt 120 attaagaaat ggagagaaaa ataagcagaa tccaccttgt ttctgaaccc agtataactc 180 attttctaca agtatcttgg gagaaaacac tggaatctgg ttttgttatt acacttactg 240 atggtcattc agcatggact gggacagttt ctgaatcaga gatttcccaa gaagctgatg 300 acatggcaat ggaaaaaggg aaatatgttg gtgaactgag aaaagcattg ttgtcaggag 360 caggaccagc tgatgtatac acgtttaatt tttctaaaga gtcttgttat ttcttctttg 420 agaaaaacct gaaagatgtc tcattcagac ttggttcctt caacctagag aaagttgaaa 480 acccagctga agtcattaga gaacttattt gttattgctt ggacaccatt gcagaaaatc 540 aagccaaaaa tgagcacctg cagaaagaaa atgaaaggct tctgagagat tggaatgatg 600 ttcaaggacg atttgaaaaa tgtgtgagtg ctaaggaagc tttggagact gatctttata 660 agcggtttat tctggtgttg aatgagaaga aaacaaaaat cagaagtttg cataataaat 720 tattaaatgc agctcaagaa cgagaaaagg acatcaaaca agaaggggaa actgcaatct 780 gttctgaaat gactgctgac cgagatccag tctatgatga gagtactgat gaggaaagtg 840 aaaaccaaac tgatctctct gggttggctt cagctgctgt aagtaaagat gattccatta 900 tttcaagtct tgatgtcact gatattgcac caagtagaaa aaggagacag cgaatgcaaa 960 gaaatcttgg gacagaacct aaaatggctc ctcaggagaa tcagcttcaa gaaaaggaaa 1020 agcctgattc ttcactacct gagacgtcga aaaaggagca catctcagct gaaaacatgt 1080 ctttagaaac tctgagaaac agcagcccag aagacctctt tgatgagatt taacagtctc 1140 aaaaaatact ttgatgttca ctagactatg ttttctattc atttctttaa aatgaaaaag 1200 gagaatttca agtcagcagc cgctattacc gtatcttaca atttaattac atacacagtg 1260 aattgaaacc attgtgcaaa atggattaca catgtataca aagatacgat ttgatgatga 1320 cactggcaca ttgagttcta aactattcat tcagcatgcc tataattaca taaattgtat 1380 gagacttttt gttgcaaagg acacatttat catattcatt cacacatatt atatgtgata 1440 gctgtccaac atcctgtctg ggaagatttt gaaaacagga caaagaaaac atcattttaa 1500 aatgtcttca gctttttttg aatagacgta ttcaaacata ttctgaacat tgatgtttga 1560 acattttaat ttgtgtgatg atgtagaaaa tataatttta gtttgtacat aaacattgtg 1620 aaaatctgat aataaaattt ttgatacatt gaaaaaaaaa 1660 <210> 586 <211> 1582 <212> DNA <213> Homo sapiens <400> 586 ccggaagtgg ggctgcctct ttaaataaca aaaatctgag gtattaagaa atggagagaa 60 aaataagcag aatccacctt gtttctgaac ccagtataac tcattttcta caagtatctt 120 gggagaaaac actggaatct ggttttgtta ttacacttac tgatggtcat tcagcatgga 180 ctgggacagt ttctgaatca gagatttccc aagaagctga tgacatggca atggaaaaag 240 ggaaatatgt tggtgaactg agaaaagcat tgttgtcagg agcaggacca gctgatgtat 300 acacgtttaa tttttctaaa gagtcttgtt atttcttctt tgagaaaaac ctgaaagatg 360 tctcattcag acttggttcc ttcaacctag agaaagttga aaacccagct gaagtcatta 420 gagaacttat ttgttattgc ttggacacca ttgcagaaaa tcaagccaaa aatgagcacc 480 tgcagaaaga aaatgaaagg cttctgagag attggaatga tgttcaagga cgatttgaaa 540 aatgtgtgag tgctaaggaa gctttggaga ctgatcttta taagcggttt attctggtgt 600 tgaatgagaa gaaaacaaaa atcagaagtt tgcataataa attattaaat gcagctcaag 660 aacgagaaaa ggacatcaaa caagaagggg aaactgcaat ctgttctgaa atgactgctg 720 accgagatcc agtctatgat gagagtactg atgaggaaag tgaaaaccaa actgatctct 780 ctgggttggc ttcagctgct gtaagtaaag atgattccat tatttcaagt cttgatgtca 840 ctgatattgc accaagtaga aaaaggagac agcgaatgca aagaaatctt gggacagaac 900 ctaaaatggc tcctcaggag aatcagcttc aagaaaagga aaagcctgat tcttcactac 960 ctgagacgtc gaaaaaggag cacatctcag ctgaaaacat gtctttagaa actctgagaa 1020 acagcagccc agaagacctc tttgatgaga tttaacagtc tcaaaaaata ctttgatgtt 1080 cactagacta tgttttctat tcatttcttt aaaatgaaaa aggagaattt caagtcagca 1140 gccgctatta ccgtatctta caatttaatt acatacacag tgaattgaaa ccattgtgca 1200 aaatggatta cacatgtata caaagatacg atttgatgat gacactggca cattgagttc 1260 taaactattc attcagcatg cctataatta cataaattgt atgagacttt ttgttgcaaa 1320 ggacacattt atcatattca ttcacacata ttatatgtga tagctgtcca acatcctgtc 1380 tgggaagatt ttgaaaacag gacaaagaaa acatcatttt aaaatgtctt cagctttttt 1440 tgaatagacg tattcaaaca tattctgaac attgatgttt gaacatttta atttgtgtga 1500 tgatgtagaa aatataattt tagtttgtac ataaacattg tgaaaatctg ataataaaat 1560 ttttgataca ttgaaaaaaa aa 1582 <210> 587 <211> 1665 <212> DNA <213> Homo sapiens <400> 587 cgggatttag atcacgtccc gcaggccggc ggaagtagct gatactctca ttggttgcaa 60 aaccttgatc tgtgaaagcg ggcgttttgg aagataccgg aagtagagtc acggagagta 120 ttaagaaatg gagagaaaaa taagcagaat ccaccttgtt tctgaaccca gtataactca 180 ttttctacaa gtatcttggg agaaaacact ggaatctggt tttgttatta cacttactga 240 tggtcattca gcatggactg ggacagtttc tgaatcagag atttcccaag aagctgatga 300 catggcaatg gaaaaaggga aatatgttgg tgaactgaga aaagcattgt tgtcaggagc 360 aggaccagct gatgtataca cgtttaattt ttctaaagag tcttgttatt tcttctttga 420 gaaaaacctg aaagatgtct cattcagact tggttccttc aacctagaga aagttgaaaa 480 cccagctgaa gtcattagag aacttatttg ttattgcttg gacaccattg cagaaaatca 540 agccaaaaat gagcacctgc agaaagaaaa tgaaaggctt ctgagagatt ggaatgatgt 600 tcaaggacga tttgaaaaat gtgtgagtgc taaggaagct ttggagactg atctttataa 660 gcggtttatt ctggtgttga atgagaagaa aacaaaaatc agaagtttgc ataataaatt 720 attaaatgca gctcaagaac gagaaaagga catcaaacaa gaaggggaaa ctgcaatctg 780 ttctgaaatg actgctgacc gagatccagt ctatgatgag agtactgatg aggaaagtga 840 aaaccaaact gatctctctg ggttggcttc agctgctgta agtaaagatg attccattat 900 ttcaagtctt gatgtcactg atattgcacc aagtagaaaa aggagacagc gaatgcaaag 960 aaatcttggg acagaaccta aaatggctcc tcaggagaat cagcttcaag aaaaggaaaa 1020 ttctaggcct gattcttcac tacctgagac gtcgaaaaag gagcacatct cagctgaaaa 1080 catgtcttta gaaactctga gaaacagcag cccagaagac ctctttgatg agatttaaca 1140 gtctcaaaaa atactttgat gttcactaga ctatgttttc tattcatttc tttaaaatga 1200 aaaaggagaa tttcaagtca gcagccgcta ttaccgtatc ttacaattta attacataca 1260 cagtgaattg aaaccattgt gcaaaatgga ttacacatgt atacaaagat acgatttgat 1320 gatgacactg gcacattgag ttctaaacta ttcattcagc atgcctataa ttacataaat 1380 tgtatgagac tttttgttgc aaaggacaca tttatcatat tcattcacac atattatatg 1440 tgatagctgt ccaacatcct gtctgggaag attttgaaaa caggacaaag aaaacatcat 1500 tttaaaatgt cttcagcttt ttttgaatag acgtattcaa acatattctg aacattgatg 1560 tttgaacatt ttaatttgtg tgatgatgta gaaaatataa ttttagtttg tacataaaca 1620 ttgtgaaaat ctgataataa aatttttgat acattgaaaa aaaaa 1665 <210> 588 <211> 1640 <212> DNA <213> Homo sapiens <400> 588 ggggaccgga agtagagtca cggagaggta ggatccggaa gtggggctgc ctctttaaat 60 aacaaaaatc tgaggtatta agaaatggag agaaaaataa gcagaatcca ccttgtttct 120 gaacccagta taactcattt tctacaagta tcttgggaga aaacactgga atctggtttt 180 gttattacac ttactgatgg tcattcagca tggactggga cagtttctga atcagagatt 240 tcccaagaag ctgatgacat ggcaatggaa aaagggaaat atgttggtga actgagaaaa 300 gcattgttgt caggagcagg accagctgat gtatacacgt ttaatttttc taaagagtct 360 tgttatttct tctttgagaa aaacctgaaa gatgtctcat tcagacttgg ttccttcaac 420 ctagagaaag ttgaaaaccc agctgaagtc attagagaac ttatttgtta ttgcttggac 480 accattgcag aaaatcaagc caaaaatgag cacctgcaga aagaaaatga aaggcttctg 540 agagattgga atgatgttca aggacgattt gaaaaatgtg tgagtgctaa ggaagctttg 600 gagactgatc tttataagcg gtttattctg gtgttgaatg agaagaaaac aaaaatcaga 660 agtttgcata ataaattatt aaatgcagct caagaacgag aaaaggacat caaacaagaa 720 ggggaaactg caatctgttc tgaaatgact gctgaccgag atccagtcta tgatgagagt 780 actgatgagg aaagtgaaaa ccaaactgat ctctctgggt tggcttcagc tgctgtaagt 840 aaagatgatt ccattatttc aagtcttgat gtcactgata ttgcaccaag tagaaaaagg 900 agacagcgaa tgcaaagaaa tcttgggaca gaacctaaaa tggctcctca ggagaatcag 960 cttcaagaaa aggaaaattc taggcctgat tcttcactac ctgagacgtc taaaaaggag 1020 cacatctcag ctgaaaacat gtctttagaa actctgagaa acagcagccc agaagacctc 1080 tttgatgaga tttaacagtc tcaaaaaata ctttgatgtt cactagacta tgttttctat 1140 tcatttcttt aaaatgaaaa aggagaattt caagtcagca gccgctatta ccgtatctta 1200 caatttaatt acatacacag tgaattgaaa ccattgtgca aaatggatta cacatgtata 1260 caaagatacg atttgatgat gacactggca cattattcta aactattcat tcagcatgcc 1320 tataattaca taaattgtat gagacttttt gttgcaaagg acacatttat catattcatt 1380 cacacatatt atatgtgata gctgtccaac atcctgtctg ggaagatttt gaaaacagga 1440 caaagaaaac atcactttaa aatgtcttca gctttttttg aatagacgta ttcaaacata 1500 ttctgaacat tgatgtttga acattttaat ttgtgtgatg atgtagaaaa tataatttta 1560 gtttgtacat aaacattgtg aaaatctgat aataaaattt ttgatacact aaaaaaaaaa 1620 aaaaaaaaaa aaaaaaaaaa 1640 <210> 589 <211> 1160 <212> DNA <213> Homo sapiens <220> <221> misc_feature <222> (1057)..(1057) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (1080)..(1080) <223> "n" means any of A, T, G, and C. <400> 589 gggctgcctc tttaaataac aaaaatctga ggtattaaga aatggagaga aaaataagca 60 gaatccacct tgtttctgaa cccagtataa ctcattttct acaagtatct tgggagaaaa 120 cactggaatc tggttttgtt attacactta ctgatggtca ttcagcatgg actgggacag 180 tttctgaatc agagatttcc caagaagctg atgacatggc aatggaaaaa gggaaatatg 240 ttggtgaact gagaaaagca ttgttgtcag gagcaggacc agctgatgta tacacgttta 300 atttttctaa agagtcttgt tatttcttct ttgagaaaaa cctgaaagat gtctcattca 360 gacttggttc cttcaaccta gagaaagttg aaaacccagc tgaagtcatt agagaactta 420 tttgttattg cttggacacc attgcagaaa atcaagccaa aaatgagcac ctgcagaaag 480 aaaatgaaag gcttctgaga gattggaatg atgttcaagg acgatttgaa aaatgtgtga 540 gtgctaagga agctttggag actgatcttt ataagcggtt tattctggtg ttgaatgaga 600 agaaaacaaa aatcagaagt ttgcataata aattattaaa tgcagctcaa gaacgagaaa 660 aggacatcaa acaagaaggg gaaactgcaa tctgttctga aatgactgct gaccgagatc 720 cagtctatga tgagagtact gatgaggaaa gtgaaaacca aactgatctc tctgggttgg 780 cttcagctgc tgtaagtaaa gatgattcca ttatttcaag tcttgatgtc actgatattg 840 caccaagtag aaaaaggaga cagcgaatgc aaagaaatct tgggacagaa cctaaaatgg 900 ctcctcagga gaatcagctt caagaaaagg aaaattctag gcctgattct tcactacctg 960 agacgtctaa aaaggagcac atctcagctg aaaacatgtc tttagaaact ctgagaaaca 1020 gcagcccaga agacctcttt gatgagattt aacagtntca aaaaatactt tgattgttcn 1080 ctagactatg ttttctattc atttctttaa aatgaaaaag gagaatttca agtcagcagc 1140 cgctattacg tcggacttaa 1160 <210> 590 <211> 1274 <212> DNA <213> Homo sapiens <400> 590 aaaccttgat ctgtgaaagc gggcgttttg gaagataccg gaagtagagt cacggagagg 60 tattaagaaa tggagagaaa aataagcaga atccaccttg tttctgaacc cagtataact 120 cattttctac aagtatcttg ggagaaaaca ctggaatctg gttttgttat tacacttact 180 gatggtcatt cagcatggac tgggacagtt tctgaatcag agatttccca agaagctgat 240 gacatggcaa tggaaaaagg gaaatatgtt ggtgaactga gaaaagcatt gttgtcagga 300 gcaggaccag ctgatgtata cacgtttaat ttttctaaag agtcttgtta tttcttcttt 360 gagaaaaacc tgaaagatgt ctcattcaga cttggttcct tcaacctaga gaaagttgaa 420 aacccagctg aagtcattag agaacttatt tgttattgct tggacaccat tgcagaaaat 480 caagccaaaa atgagcacct gcagaaagaa aatgaaaggc ttctgagaga ttggaatgat 540 gttcaaggac gatttgaaaa atgtgtgagt gctaaggaag ctttggagac tgatctttat 600 aagcggttta ttctggtgtt gaatgagaag aaaacaaaaa tcagaagttt gcataataaa 660 ttattaaatg cagctcaaga acgagaaaag gacatcaaac aagaagggga aactgcaatc 720 tgttctgaaa tgactgctga ccgagatcca gtctatgatg agagtactga tgaggaaagt 780 gaaaaccaaa ctgatctctc tgggttggct tcagctgctg taagtaaaga tgattccatt 840 atttcaagtc ttgatgtcac tgatattgca ccaagtagaa aaaggagaca gcgaatgcaa 900 agaaatcttg ggacagaacc taaaatggct cctcaggaga atcagcttca agaaaaggaa 960 aaagggagga agaaggagac ttcagagaaa gaggccgtgt gatggaagca aaatcagaga 1020 gaaaagatgc taagctgctg cctttgaata aggaggaacg tgagccaaca gatccaagaa 1080 ctgaagctct aggcagtgga aaagccaagg aaactgatct tcccttcgag cctccggagg 1140 gagtgtagcc ctgccaacac ctttatttta gccccataac agtcatttca gacttgtggc 1200 ctccagaatt ttaagagaat aaatttttat tgtattaagc catgaaaaaa aaaaaaaaaa 1260 aaaaaaaaaa aaaa 1274 <210> 591 <211> 933 <212> DNA <213> Homo sapiens <400> 591 atggagagaa aaataagcag aatccacctt gtttctgaac ccagtataac tcattttcta 60 caagtatctt gggagaaaac actggaatct ggttttgtta ttacacttac tgatggtcat 120 tcagcatgga ctgggacagt ttctgaatca gagatttccc aagaagctga tgacatggca 180 atggaaaaag ggaaatatgt tggtgaactg agaaaagcat tgttgtcagg agcaggacca 240 gctgatgtat acacgtttaa tttttctaaa gagtcttgtt atttcttctt tgagaaaaac 300 ctgaaagatg tctcattcag acttggttcc ttcaacctag agaaagttga aaacccagct 360 gaagtcatta gagaacttat ttgttattgc ttggacacca ttgcagaaaa tcaagccaaa 420 aatgagcacc tgcagaaaga aaatgaaagg cttctgagag attggaatga tgttcaagga 480 cgatttgaaa aatgtgtgag tgctaaggaa gctttggaga ctgatcttta taagcggttt 540 attctggtgt tgaatgagaa gaaaacaaaa atcagaagtt tgcataataa attattaaat 600 gcagctcaag aacgagaaaa ggacatcaaa caagaagggg aaactgcaat ctgttctgaa 660 atgactgctg accgagatcc agtctatgat gagagtactg atgaggaaag tgaaaaccaa 720 actgatctct ctgggttggc ttcagctgct gtaagtaaag atgattccat tatttcaagt 780 cttgatgtca ctgatattgc accaagtaga aaaaggagac agcgaatgca aagaaatctt 840 gggacagaac ctaaaatggc tcctcaggag aatcagcttc aagaaaagga aaaagggagg 900 aagaaggaga cttcagagaa agaggccgtg tag 933 <210> 592 <211> 931 <212> DNA <213> Homo sapiens <400> 592 tggagaggcg atgagcaagg agcagattct aggtgtgctt agaggcagca ggatttgctg 60 atgaaggggt tatgactgag caaataagac tgagaaggag cagccaggag ctgctgtaag 120 taaagatgat tccattattt caagtcttga tgtcactgat attgcaccaa gtagaaaaag 180 gagacagcga atgcaaagaa atcttgggac agaacctaaa atggctcctc aggagaatca 240 gcttcaagaa aaggaaaatt ctaggcctga ttcttcacta cctgagacgt ctaaaaagga 300 gcacatctca gctgaaaaca tgtctttaga aactctgaga aacagcagcc cagaagaaac 360 cttttgtagt atttaacagt ctcaaaaaat actttgatgt tcactagact atgttttcta 420 ttcatttctt taaaatgaaa aaggagaatt tcaagtcagc agccgctatt accgtatctt 480 acaatttaat tacagacaca gtgaattgaa accattgtgc aaaatggatt acacatgtat 540 acaaagatac gatttgatga tgacactggc acattattct aaactattca ttcagcatgc 600 ctataattac ataaattgta tgagactttt tgttgcaaag gacacattta tcatattcat 660 tcacacatat tatatgtgat agctgtccaa catcctgtct gggaagattt tgaaaacagg 720 acaaagaaaa catcatttta aaatgtcttc agcttttttt gaatagacgt attcaaacat 780 attctgaaca ttgatgtttg aacattttaa tttgtgtgat gatgtagaaa atataatttt 840 agtttgtaca taaacattgt gaaaatctga taataaaatt tttgatacat tgaaaaaaaa 900 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a 931 <210> 593 <211> 2095 <212> DNA <213> Homo sapiens <400> 593 acgtttaaag ctgagcgacc cagtgccact ggagacggtc agcttctcca ctcaggctcc 60 tccagcccga gccagaagac cccctccccc ataattctgg gggccgatgg aagggagccg 120 agtcagatcg cgaggtaccc atagccgaca gaccggagcg acagggagtt gccataagcc 180 ccgcccctag gagtgatcgg aaagcctcac ccatccgggt gaggaacccg gagggaccgc 240 ctccgggcgg agcccgccga ccatggctac gcccctggtg gcgggtcccg cagctctacg 300 cttcgccgcc gcggctagct ggcaggttgt gcgcggacgc tgcgtggaac attttccgcg 360 agtactggag tttctgcgat ctctgcgcgc tgttgcccct ggcttggttc gctaccggca 420 ccacgaacgc ctttgtatgg gcctaaaggc caaggtggtg gtggagctga tcctgcaggg 480 ccggccttgg gcccaagtcc tgaaagccct gaatcaccac tttccagaat ctggacctat 540 agtgcgggat cccaaggcta caaagcagga tctgaggaag attttggagg cacaggaaac 600 tttttaccag caggtgaagc agctgtcaga ggctcctgtg gatttggcct cgaagctgca 660 ggaacttgaa caagagtatg gggaaccctt tctggctgcc atggaaaagc tgctttttga 720 gtacttgtgt cagctggaga aagcactgcc tacaccgcag gcacagcagc ttcaggatgt 780 gctgagttgg atgcagcctg gagtctctat cacctcttct cttgcctgga gacaatatgg 840 tgtggacatg gggtggctgc ttccagagtg ctctgttact gactcagtga acctggctga 900 gcccatggaa cagaatcctc ctcagcaaca aagactagca ctccacaatc ccctgccaaa 960 agccaagcct ggcacacatc ttcctcaggg accatcttca aggacgcacc cagaacctct 1020 agctggccga cacttcaatc tggcccctct aggccgacga agagttcagt cccaatgggc 1080 ctccactagg ggaggccata aggagcgccc cacagtcatg ctgtttccct ttaggaatct 1140 cggctcacca acccaggtca tatctaatcc tgagagcaag gaagaacatg cgatatacac 1200 agcagaccta gccatgggca caagagcacc ctccaatggg aagtataagg gtccatacca 1260 gaccctgggg ggaagggctc tgaaggagaa cccagttgac ttgcctgcca cagagcaaaa 1320 ggagtgagtg gaacagagtt gcttcttaat aggagcacat tctttgcctg ccttcccttc 1380 atcctatcct ctttgcttgc tctcacctca ggaattgctt ggattgatac atggaccccc 1440 tgagactatc attattacct cctagggcca ggaagccagg taggtagtct gagtcaggat 1500 tggatcaaca gcctcctctc ttggggactc tcaagagcct gtgttcatct agaagtagta 1560 gtttgattct ggtttccctc atacagtgtg tcctccgtct ctgtgcagct ccgtcattac 1620 cataggggac ttggttttag actctgatga ggaagaaaat ggccaggggg aaggaaaggt 1680 gagtgggaag gagcagaaag ctgggaaagg ggatgggtag aacaagactg agaaatccac 1740 atgcttcaga attcagaggg ttcagggaat ggtttcggat agtaggctct ccctgctccc 1800 ttctatacag gaatctctgg aaaactatca gaagacaaag tttgacacct tgatacccac 1860 tttttgtgaa tacctacccc cttctggcca cggtgccata cctgtttctt cctgtgactg 1920 tagaaacagt tctagacctt tgtgatagaa ctaaaatgct ctctgtactc tagtctcctg 1980 cctcctcagt tctgcaagta gtttagtagg aatgaagtgg aagtccaggc ttggattgcc 2040 taactacact gctaaaaata tttgtaatcc ttaataatta aactttggat ttgtt 2095 <210> 594 <211> 2095 <212> DNA <213> Homo sapiens <400> 594 acgtttaaag ctgagcgacc cagtgccact ggagacggtc agcttctcca ctcaggctcc 60 tccagcccga gccagaagac cccctccccc ataattctgg gggccgatgg aagggagccg 120 agtcagatcg cgaggtaccc atagccgaca gaccggagcg acagggagtt gccataagcc 180 ccgcccctag gagtgatcgg aaagcctcac ccatccgggt gaggaacccg gagggaccgc 240 ctccgggcgg agcccgccga ccatggctac gcccctggtg gcgggtcccg cagctctacg 300 cttcgccgcc gcggctagct ggcaggttgt gcgcggacgc tgcgtggaac attttccgcg 360 agtactggag tttctgcgat ctctgcgcgc tgttgcccct ggcttggttc gctaccggca 420 ccacgaacgc ctttgtatgg gcctaaaggc caaggtggtg gtggagctga tcctgcaggg 480 ccggccttgg gcccaagtcc tgaaagccct gaatcaccac tttccagaat ctggacctat 540 agtgcgggat cccaaggcta caaagcagga tctgaggaag attttggagg cacaggaaac 600 tttttaccag caggtgaagc agctgtcaga ggctcctgtg gatttggcct cgaagctgca 660 ggaacttgaa caagagtatg gggaaccctt tctggctgcc atggaaaagc tgctttttga 720 gtacttgtgt cagctggaga aagcactgcc tacaccgcag gcacagcagc ttcaggatgt 780 gctgagttgg atgcagcctg gagtctctat cacctcttct cttgcctgga gacaatatgg 840 tgtggacatg gggtggctgc ttccagagtg ctctgttact gactcagtga acctggctga 900 gcccatggaa cagaatcctc ctcagcaaca aagactagca ctccacaatc ccctgccaaa 960 agccaagcct ggcacacatc ttcctcaggg accatcttca aggacgcacc cagaacctct 1020 agctggccga cacttcaatc tggcccctct aggccgacga agagttcagt cccaatgggc 1080 ctccactagg ggaggccata aggagcgccc cacagtcatg ctgtttccct ttaggaatct 1140 cggctcacca acccaggtca tatctaatcc tgagagcaag gaagaacatg cgatatacac 1200 agcagaccta gccatgggca caagagcacc ctccaatggg aagtataagg gtccatacca 1260 gaccctgggg ggaagggctc tgaaggagaa cccagttgac ttgcctgcca cagagcaaaa 1320 ggagtgagtg gaacagagtt gcttcttaat aggagcacat tctttgcctg ccttcccttc 1380 atcctatcct ctttgcttgc tctcacctca ggaattgctt ggattgatac atggaccccc 1440 tgagactatc attattacct cctagggcca ggaagccagg taggtagtct gagtcaggat 1500 tggatcaaca gcctcctctc ttggggactc tcaagagcct gtgttcatct agaagtagta 1560 gtttgattct ggtttccctc atacagtgtg tcctccgtct ctgtgcagct ccgtcattac 1620 cataggggac ttggttttag actctgatga ggaagaaaat ggccaggggg aaggaaaggt 1680 gagtgggaag gagcagaaag ctgggaaagg ggatgggtag aacaagactg agaaatccac 1740 atgcttcaga attcagaggg ttcagggaat ggtttcggat agtaggctct ccctgctccc 1800 ttctatacag gaatctctgg aaaactatca gaagacaaag tttgacacct tgatacccac 1860 tttttgtgaa tacctacccc cttctggcca cggtgccata cctgtttctt cctgtgactg 1920 tagaaacagt tctagacctt tgtgatagaa ctaaaatgct ctctgtactc tagtctcctg 1980 cctcctcagt tctgcaagta gtttagtagg aatgaagtgg aagtccaggc ttggattgcc 2040 taactacact gctaaaaata tttgtaatcc ttaataatta aactttggat ttgtt 2095 <210> 595 <211> 1851 <212> DNA <213> Homo sapiens <400> 595 gccggaagtg aggcaccctc gggctcgaga cagcggcgac gtttaaagct gagcgaccca 60 gtgccactgg agacggtcag cttctccact caggctcctc cagcccgagc cagaagaccc 120 cctcccccag aattctgggg gccgatggaa gggagccgag tcagatcgcg aggtacccag 180 agccgacaga ccggagcgac agggagttgc cagaagcccc gcccctagga gtgatcggaa 240 agcctcaccc atccgggtga ggaacccgga gggaccgcct ccgggcggag cccgccgacc 300 atggctacgc ccctggtggc gggtcccgca gctctacgct tcgccgccgc ggctagctgg 360 caggttgtgc gcggacgctg cgtggaacat tttccgcgag tactggagtt tctgcgatct 420 ctgcgcgctg ttgcccctgg cttggttcgc taccggcacc acgaacgcct ttgtatgggc 480 ctaaaggcca aggtggtggt ggagctgatc ctgcagggcc ggccttgggc ccaagtcctg 540 aaagccctga atcaccactt tccagaatct ggacctatag tgcgggatcc caaggctaca 600 aagcaggatc tgaggaagat tttggaggca caggaaactt tttaccagca ggtgaagcag 660 ctgtcagagg ctcctgtgga tttggcctcg aagctgcagg aacttgaaca agagtatggg 720 gaaccctttc tggctgccat ggaaaagctg ctttttgagt acttgtgtca gctggagaaa 780 gcactgccta caccgcaggc acagcagctt caggatgtgc tgagttggat gcagcctgga 840 gtctctatca cctcttctct tgcctggaga caatatggtg tggacatggg gtggctgctt 900 ccagagtgct ctgttactga ctcagtgaac ctggctgagc ccatggaaca gaatcctcct 960 cagcaacaaa gactagcact ccacaatccc ctgccaaaag ccaagcctgg cacacatctt 1020 cctcagggac catcttcaag gacgcaccca gaacctctag ctggccgaca cttcaatctg 1080 gcccctctag gccgacgaag agttcagtcc caatgggcct ccactagggg aggccataag 1140 gagcgcccca cagtcatgct gtttcccttt aggaatctcg gctcaccaac ccaggtcata 1200 tctaagcctg agagcaagga agaacatgcg atatacacag cagacctagc catgggcaca 1260 agagcagcct ccactgggaa gtctaagagt ccatgccaga ccctgggggg aagggctctg 1320 aaggagaacc cagttgactt gcctgccaca gagcaaaagg agaattgctt ggattgctac 1380 atggaccccc tgagactatc attattacct cctagggcca ggaagccagt gtgtcctccg 1440 tctctgtgca gctccgtcat taccataggg gacttggttt tagactctga tgaggaagaa 1500 aatggccagg gggaaggaaa ggaatctctg gaaaactatc agaagacaaa gtttgacacc 1560 ttgataccca ctctctgtga atacctaccc ccttctggcc acggtgccat acctgtttct 1620 tcctgtgact gtagagacag ttctagacct ttgtgataga actaaaatgc tctctgtact 1680 ctagtctcct gcctcctcag ctctgcaagt agtttagtag gaatgaagtg gaagtccagg 1740 cttggattgc ctaactacac tgctaaaaat atttgtaatc cttaataatt aaactttgga 1800 tttgttaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a 1851 <210> 596 <211> 1655 <212> DNA <213> Homo sapiens <400> 596 cagagccgac agaccggagc gacagggagt tgccagaagc cccgccccta ggagtgatcg 60 gaaagcctca cccatccggg tgaggaaccc ggagggaccg cctccgggcg gagcccgccg 120 accatggcta cgcccctggt ggcgggtccc gcagctctac gcttcgccgc cgcggctagc 180 tggcaggttg tgcgcggacg ctgcgtggaa cattttccgc gagtactgga gtttctgcga 240 tctctgcgcg ctgttgcccc tggcttggtt cgctaccggc accacgaacg cctttgtatg 300 ggcctaaagg ccaaggtggt ggtggagctg atcctgcagg gccggccttg ggcccaagtc 360 ctgaaagccc tgaatcacca ctttccagaa tctggaccta tagtgcggga tcccaaggct 420 acaaagcagg atctgaggaa gattttggag gcacaggaaa ctttttacca gcaggtgaag 480 cagctgtcag aggctcctgt ggatttggcc tcgaagctgc aggaacttga acaagagtat 540 ggggaaccct ttctggctgc catggaaaag ctgctttttg agtacttgtg tcagctggag 600 aaagcactgc ctacaccgca ggcacagcag cttcaggatg tgctgagttg gatgcagcct 660 ggagtctcta tcacctcttc tcttgcctgg agacaatatg gtgtggacat ggggtggctg 720 cttccagagt gctctgttac tgactcagtg aacctggctg agcccatgga acagaatcct 780 cctcagcaac aaagactagc actccacaat cccctgccaa aagccaagcc tggcacacat 840 cttcctcagg gaccatcttc aaggacgcac ccagaacctc tagctggccg acacttcaat 900 ctggcccctc taggccgacg aagagttcag tcccaatggg cctccactag gggaggccat 960 aaggagcgcc ccacagtcat gctgtttccc tttaggaatc tcggctcacc aacccaggtc 1020 atatctaagc ctgagagcaa ggaagaacat gcgatataca cagcagacct agccatgggc 1080 acaagagcag cctccactgg gaagtctaag agtccatgcc agaccctggg gggaagggct 1140 ctgaaggaga acccagttga cttgcctgcc acagagcaaa aggagaattg cttggattgc 1200 tacatggacc ccctgagact atcattatta cctcctaggg ccaggaagcc agtgtgtcct 1260 ccgtctctgt gcagctccgt cattaccata ggggacttgg ttttagactc tgatgaggaa 1320 gaaaatggcc agggggaagg aaaggaatct ctggaaaact atcagaagac aaagtttgac 1380 accttgatac ccactctctg tgaataccta cccccttctg gccacggtgc catacctgtt 1440 tcttcctgtg actgtagaga cagttctaga cctttgtgat agaactaaaa tgctctctgt 1500 actctagtct cctgcctcct cagctctgca agtagtttag taggaatgaa gtggaagtcc 1560 aggcttggat tgcctaacta cactgctaaa aatatttgta atccttaata attaaacttt 1620 ggatttgtta aaaaaaaaaa aaaaaaaaaa aaaaa 1655 <210> 597 <211> 2566 <212> DNA <213> Homo sapiens <400> 597 accctcgggc tcgagacagc ggcgacgttt aaagctgagc gacccagtgc cactggagac 60 ggtcagcttc tccactcagg ctcctccagc ccgagccaga agaccccctc ccccagaatt 120 ctgggggccg atggaaggga gccgagtcag atcgcgaggt acccagagcc gacagaccgg 180 agcgacaggg agttgccaga agccccgccc ctaggagtga tcggaaagcc tcacccatcc 240 gggtgaggaa cccggaggga ccgcctccgg gcggagcccg ccgaccatgg ctacgcccct 300 ggtggcgggt cccgcagctc tacgcttcgc cgccgcggct agctggcagg ttgtgcgcgg 360 acgctgcgtg gaacattttc cgcgagtact ggagtttctg cgatctctgc gcgctattgc 420 ccctggcttg gttcgctacc ggcaccacga acgcctttgt atgggcctaa aggccaaggt 480 ggtggagctg atcctgcagg gccggccttg ggcccaagtc ctgaaagccc tgaatcacca 540 ctttccagaa tctggaccta tagtgcggga tcccaaggct acaaagcagg atctgaggaa 600 gattttggag gcacaggaaa ctttttacca gcaggtgaag cagctgtcag aggctcctgt 660 ggatttggcc tcgaagctgc aggtgagact ggtttgaagg ctattatgtg gctattttct 720 ctaacccatt tttttttttt tttgaggaat cttgctctgt cgcccaggct ggagtgcagt 780 ggcacaatct cggctcactg caacctctgc ctcccgggtt caagcgattc tcctgcctca 840 gcctcccgag tagctgggat tacaaatgcc cagctaattt ttgtatttta gtagagatgg 900 ggtttcacca tgttggccag gctggtctcg aactcctgac ctcaagtgat ccgcccacct 960 cggcctccca aatggccagg attacaggcg tgagccaccg tgcctggcca ctaacccact 1020 tttgacctaa tctcccctgc tgtaggaact tgaacaagag tatggggaac cctttctggc 1080 tgccatggaa aagctgcttt ttgagtactt gtgtcagctg gagaaagcac tgcctacacc 1140 gcaggcacag caggtttcgc tggggcaaaa catgtaaggg cagagtgtgg ggtggctgtt 1200 tcaaggattg tggtcttcat acctctgtcc ctgcccacag cttcaggatg tgctgagttg 1260 gatgcagcct ggagtctcta tcacctcttc tcttgcctgg agacaatatg gtgtggacat 1320 ggggtggctg cttccagagt gctctgttac tgactcagtg aacctggctg agcccatgga 1380 acagaatcct cctcagcaac aaagactagc actccacaat cccctgccaa aagccaagcc 1440 tggcacacat cttcctcagg gaccatcttc aaggacgcac ccagaacctc tagctggccg 1500 acacttcaat ctggcccctc taggccgacg aagagttcag tcccaatggg cctccactag 1560 gggaggccat aaggagcgcc ccacagtcat gctgtttccc tttaggaatc tcggctcacc 1620 aacccaggtc atatctaagc ctgagagcaa ggaagaacat gcgatataca cagcagacct 1680 agccatgggc acaagagcag cctccactgg gaagtctaag agtccatgcc agaccctggg 1740 gggaagggct ctgaaggaga acccagttga cttgcctgcc acagagcaaa aggagtgagt 1800 ggaacagagt tgcttcttac taggagcaca ttctttgcct gccttccctt catcctatcc 1860 tctttgcttg ctctcacctc aggaattgct tggattgcta catggacccc ctgagactat 1920 cattattacc tcctagggcc aggaagccag gtaggtagtc tgagtcagga ttggatcaac 1980 agcctcctct cttggggact ctcaagagcc tgtgttcatc tagaagtagt agtttgattc 2040 tggtttccct cctacagtgt gtcctccgtc tctgtgcagc tccgtcatta ccatagggga 2100 cttggtttta gactctgatg gggaagaaaa tggccagggg gaaggaaagg tgagtggaaa 2160 ggagcagaaa gctgggaaag gggatgggta gaacaagact gagaaatcca catgcttcag 2220 aattcagagg gttcagggaa tggtttcgga tagtaggctc tccctgctcc cttctctaca 2280 ggaatctctg gaaaactatc agaagacaaa gtttgacacc ttgataccca ctctctgtga 2340 atacctaccc ccttctggcc acggtgccat acctgtttct tcctgtgact gtagagacag 2400 ttctagacct ttgtgataaa actaaaatgc tctctgtact ctagtctcct gcctcctcag 2460 ctctgcaagt agtttagtag gaatgaagtg gaagtccagg cttggattgc ctaactacac 2520 tgctaaaaat atttgtaatc cttaataatt aaactttgga tttgtt 2566 <210> 598 <211> 1868 <212> DNA <213> Homo sapiens <400> 598 cgagacagcg gcgacgttta aagctgagcg acccagtgcc actggagacg gtcagcttct 60 ccactcaggc tcctccagcc cgagccagaa gaccccctcc cccagaattc tgggggccga 120 tggaagggag ccgagtcaga tcgcgaggta cccagagccg acagaccgga gcgacaggga 180 gttgccagaa gccccgcccc taggagtgat cggaaagcct cacccatccg ggtgaggaac 240 ccggagggac cgcctccggg cggagcccgc cgaccatggc tacgcccctg gtggcgggtc 300 ccgcagctct acgcttcgcc gccgcggcta gctggcaggt tgtgcgcgga cgctgcgtgg 360 aacattttcc gcgagtactg gagtttctgc gatctctgcg cgctgttgcc cctggcttgg 420 ttcgctaccg gcaccacgaa cgcctttgta tgggcctaaa ggccaaggtg gtggtggagc 480 tgatcctgca gggccggcct tgggcccaag tcctgaaagc cctgaatcac cactttccag 540 aatctggacc tatagtgcgg gatcccaagg ctacaaagca ggatctgagg aagattttgg 600 aggcacagga aactttttac cagcaggtga agcagctgtc agaggctcct gtggatttgg 660 cctcgaagct gcagagtgct ctgttactga ctcagtgaac ctggctgagc ccatggaaca 720 gaatcctcct cagcaacaaa gactagcact ccacaatccc ctgccaaaag ccaagcctgg 780 cacacatctt cctcagggac catcttcaag gacgcaccca gaacctctag ctggccgaca 840 cttcaatctg gcccctctag gccgacgaag agttcagtcc caatgggcct ccactagggg 900 aggccataag gagcgcccca cagtcatgct gtttcccttt aggaatctcg gctcaccaac 960 ccaggtcata tctaagcctg agagcaagga agaacatgcg atatacacag cagacctagc 1020 catgggcaca agagcagcct ccactgggaa gtctaagagt ccatgccaga ccctgggggg 1080 aagggctctg aaggagaacc cagttgactt gcctgccaca gagcaaaagg agtgagtgga 1140 acagagttgc ttcttactag gagcacattc tttgcctgcc ttcccttcat cctatcctct 1200 ttgcttgctc tcacctcagg aattgcttgg attgctacat ggaccccctg agactatcat 1260 tattacctcc tagggccagg aagccaggta ggtagtctga gtcaggattg gatcaacagc 1320 ctcctctctt ggggactctc aagagcctgt gttcatctag aagtagtagt ttgattctgg 1380 tttccctcct acagtgtgtc ctccgtctct gtgcagctcc gtcattacca taggggactt 1440 ggttttagac tctgatgagg aagaaaatgg ccagggggaa ggaaaggtga gtgggaagga 1500 gcagaaagct gggaaagggg atgggtagaa caagactgag aaatccacat gcttcagaat 1560 tcagagggtt cagggaatgg tttcggatag taggctctcc ctgctccctt ctctacagga 1620 atctctggaa aactatcaga agacaaagtt tgacaccttg atacccactc tctgtgaata 1680 cctaccccct tctggccacg gtgccatacc tgtttcttcc tgtgactgta gagacagttc 1740 tagacctttg tgatagaact aaaatgctct ctgtactcta gtctcctgcc tcctcagctc 1800 tgcaagtagt ttagtaggaa tgaagtggaa gtccaggctt ggattgccta actacactgc 1860 taaaaata 1868 <210> 599 <211> 1963 <212> DNA <213> Homo sapiens <400> 599 gtgttgtacg aaagcgcgtc tgcggccgca atgtctgctg agagttgtag ttctgtgccc 60 tatcacggcc actcccattt ctggtgccgt cacgggacag agcagtcggt gacaggacag 120 agcagtcggt gacgggacac agtggttggt gacgggacag agcggtcggt gacagcctca 180 agggcttcag caccgcgccc atggcagagc cagacccctc tcaccctctg gagacccagg 240 cagggaaggt gcaggaggct caggactcag attcagactc tgagggagga gccgctggtg 300 gagaagcaga catggacttc ctgcggaact tattctccca gacgctcagc ctgggcagcc 360 agaaggagcg tctgctggac gagctgacct tggaaggggt ggcccggtac atgcagagcg 420 aacgctgtcg cagagtcatc tgtttggtgg gagctggaat ctccacatcc gcaggcatcc 480 ccgactttcg ctctccatcc accggcctct atgacaacct agagaagtac catcttccct 540 acccagaggc catctttgag atcagctatt tcaagaaaca tccggaaccc ttcttcgccc 600 tcgccaagga actctatcct gggcagttca agccaaccat ctgtcactac ttcatgcgcc 660 tgctgaagga caaggggcta ctcctgcgct gctacacgca gaacatagat accctggagc 720 gaatagccgg gctggaacag gaggacttgg tggaggcgca cggcaccttc tacacatcac 780 actgcgtcag cgccagctgc cggcacgaat acccgctaag ctggatgaaa gagaagatct 840 tctctgaggt gacgcccaag tgtgaagact gtcagagcct ggtgaagcct gatatcgtct 900 tttttggtga gagcctccca gcgcgtttct tctcctgtat gcagtcagac ttcctgaagg 960 tggacctcct cctggtcatg ggtacctcct tgcaggtgca gccctttgcc tccctcatca 1020 gcaaggcacc cctctccacc cctcgcctgc tcatcaacaa ggagaaagct ggccagtcgg 1080 accctttcct ggggatgatt atgggcctcg gaggaggcat ggactttgac tccaagaagg 1140 cctacaggga cgtggcctgg ctgggtgaat gcgaccaggg ctgcctggcc cttgctgagc 1200 tccttggatg gaagaaggag ctggaggacc ttgtccggag ggagcacgcc agcatagatg 1260 cccagtcggg ggcgggggtc cccaacccca gcacttcagc ttcccccaag aagtccccgc 1320 cacctgccaa ggacgaggcc aggacaacag agagggagaa accccagtga cagctgcatc 1380 tcccaggcgg gatgccgagc tcctcaggga cagctgagcc ccaaccgggc ctggccccct 1440 cttaaccagc agttcttgtc tggggagctc agaacatccc ccaatctctt acagctccct 1500 ccccaaaact ggggtcccag caaccctggc ccccaacccc agcaaatctc taacacctcc 1560 tagaggccaa ggcttaaaca ggcatctcta ccagccccac tgtctctaac cactcctggg 1620 ctaaggagta acctccctca tctctaactg cccccacggg gccagggcta ccccagaact 1680 tttaactctt ccaggacagg gagcttcggg cccccactct gtctcctgcc cccgggggcc 1740 tgtggctaag taaaccatac ctaacctacc ccagtgtggg tgtgggcctc tgaatataac 1800 ccacacccag cgtaggggga gtctgagccg ggagggctcc cgagtctctg ccttcagctc 1860 ccaaagtggg tggtgggccc ccttcacgtg ggacccactt cccatgctgg atgggcagaa 1920 gacattgctt attggagaca aattaaaaac aaaaacaact aac 1963 <210> 600 <211> 1931 <212> DNA <213> Homo sapiens <400> 600 cgaaagcgcg tctgcggccg caatgtctgc tgagagttgt agttctgtgc cctatcacgg 60 ccactcccat ttctggtgcc gtcacgggac agagcagtcg gtgacaggac agagcagtcg 120 gtgacgggac acagtggttg gtgacgggac agagcggtcg gtgacagcct caagggcttc 180 agcaccgcgc ccatggcaga gccagaccga ctcagattca gactctgagg gaggagccgc 240 tggtggagaa gcagacatgg acttcctgcg gaacttattc tcccagacgc tcagcctggg 300 cagccagaag gagcgtctgc tggacgagct gaccttggaa ggggtggccc ggtacatgca 360 gagcgaacgc tgtcgcagag tcatctgttt ggtgggagct ggaatctcca catccgcagg 420 catccccgac tttcgctctc catccaccgg cctctatgac aacctagaga agtaccatct 480 tccctaccca gaggccatct ttgagatcag ctatttcaag aaacatccgg aacccttctt 540 cgccctcgcc aaggaactct atcctgggca gttcaagcca accatctgtc actacttcat 600 gcgcctgctg aaggacaagg ggctactcct gcgctgctac acgcagaaca tagataccct 660 ggagcgaata gccgggctgg aacaggagga cttggtggag gcgcacggca ccttctacac 720 atcacactgc gtcagcgcca gctgccggca cgaatacccg ctaagctgga tgaaagagaa 780 gatcttctct gaggtgacgc ccaagtgtga agactgtcag agcctggtga agcctgatat 840 cgtctttttt ggtgagagcc tcccagcgcg tttcttctcc tgtatgcagt cagacttcct 900 gaaggtggac ctcctcctgg tcatgggtac ctccttgcag gtgcagccct ttgcctccct 960 catcagcaag gcacccctct ccacccctcg cctgctcatc aacaaggaga aagctggcca 1020 gtcggaccct ttcctgggga tgattatggg cctcggagga ggcatggact ttgactccaa 1080 gaaggcctac agggacgtgg cctggctggg tgaatgcgac cagggctgcc tggcccttgc 1140 tgagctcctt ggatggaaga aggagctgga ggaccttgtc cggagggagc acgccagcat 1200 agatgcccag tcgggggcgg gggtccccaa ccccagcact tcagcttccc ccaagaagtc 1260 cccgccacct gccaaggacg aggccaggac aacagagagg gagaaacccc agtgacagct 1320 gcatctccca ggcgggatgc cgagctcctc agggacagct gagccccaac cgggcctggc 1380 cccctcttaa ccagcagttc ttgtctgggg agctcagaac atcccccaat ctcttacagc 1440 tccctcccca aaactggggt cccagcaacc ctggccccca accccagcaa atctctaaca 1500 cctcctagag gccaaggctt aaacaggcat ctctaccagc cccactgtct ctaaccactc 1560 ctgggctaag gagtaacctc cctcatctct aactgccccc acggggccag ggctacccca 1620 gaacttttaa ctcttccagg acagggagct tcgggccccc actctgtctc ctgcccccgg 1680 gggcctgtgg ctaagtaaac catacctaac ctaccccagt gtgggtgtgg gcctctgaat 1740 ataacccaca cccagcgtag ggggagtctg agccgggagg gctcccgagt ctctgccttc 1800 agctcccaaa gtgggtggtg ggcccccttc acgtgggacc cacttcccat gctggatggg 1860 cagaagacat tgcttattgg agacaaatta aaaacaaaaa caactaacaa aaaaaaaaaa 1920 aaaaaaaaaa a 1931 <210> 601 <211> 1931 <212> DNA <213> Homo sapiens <400> 601 cgaaagcgcg tctgcggccg caatgtctgc tgagagttgt agttctgtgc cctatcacgg 60 ccactcccat ttctggtgcc gtcacgggac agagcagtcg gtgacaggac agagcagtcg 120 gtgacgggac acagtggttg gtgacgggac agagcggtcg gtgacagcct caagggcttc 180 agcaccgcgc ccatggcaga gccagaccga ctcagattca gactctgagg gaggagccgc 240 tggtggagaa gcagacatgg acttcctgcg gaacttattc tcccagacgc tcagcctggg 300 cagccagaag gagcgtctgc tggacgagct gaccttggaa ggggtggccc ggtacatgca 360 gagcgaacgc tgtcgcagag tcatctgttt ggtgggagct ggaatctcca catccgcagg 420 catccccgac tttcgctctc catccaccgg cctctatgac aacctagaga agtaccatct 480 tccctaccca gaggccatct ttgagatcag ctatttcaag aaacatccgg aacccttctt 540 cgccctcgcc aaggaactct atcctgggca gttcaagcca accatctgtc actacttcat 600 gcgcctgctg aaggacaagg ggctactcct gcgctgctac acgcagaaca tagataccct 660 ggagcgaata gccgggctgg aacaggagga cttggtggag gcgcacggca ccttctacac 720 atcacactgc gtcagcgcca gctgccggca cgaatacccg ctaagctgga tgaaagagaa 780 gatcttctct gaggtgacgc ccaagtgtga agactgtcag agcctggtga agcctgatat 840 cgtctttttt ggtgagagcc tcccagcgcg tttcttctcc tgtatgcagt cagacttcct 900 gaaggtggac ctcctcctgg tcatgggtac ctccttgcag gtgcagccct ttgcctccct 960 catcagcaag gcacccctct ccacccctcg cctgctcatc aacaaggaga aagctggcca 1020 gtcggaccct ttcctgggga tgattatggg cctcggagga ggcatggact ttgactccaa 1080 gaaggcctac agggacgtgg cctggctggg tgaatgcgac cagggctgcc tggcccttgc 1140 tgagctcctt ggatggaaga aggagctgga ggaccttgtc cggagggagc acgccagcat 1200 agatgcccag tcgggggcgg gggtccccaa ccccagcact tcagcttccc ccaagaagtc 1260 cccgccacct gccaaggacg aggccaggac aacagagagg gagaaacccc agtgacagct 1320 gcatctccca ggcgggatgc cgagctcctc agggacagct gagccccaac cgggcctggc 1380 cccctcttaa ccagcagttc ttgtctgggg agctcagaac atcccccaat ctcttacagc 1440 tccctcccca aaactggggt cccagcaacc ctggccccca accccagcaa atctctaaca 1500 cctcctagag gccaaggctt aaacaggcat ctctaccagc cccactgtct ctaaccactc 1560 ctgggctaag gagtaacctc cctcatctct aactgccccc acggggccag ggctacccca 1620 gaacttttaa ctcttccagg acagggagct tcgggccccc actctgtctc ctgcccccgg 1680 gggcctgtgg ctaagtaaac catacctaac ctaccccagt gtgggtgtgg gcctctgaat 1740 ataacccaca cccagcgtag ggggagtctg agccgggagg gctcccgagt ctctgccttc 1800 agctcccaaa gtgggtggtg ggcccccttc acgtgggacc cacttcccat gctggatggg 1860 cagaagacat tgcttattgg agacaaatta aaaacaaaaa caactaacaa aaaaaaaaaa 1920 aaaaaaaaaa a 1931 <210> 602 <211> 1859 <212> DNA <213> Homo sapiens <400> 602 attttttctg gtgccgtcac gggacagagc agtcggtgac aggacagagc agtcggtgac 60 gggacacagt ggttggtgac gggacagagc ggtcggtgac agcctcaagg gcttcagcac 120 cgcgcccatg gcagagccag accgactcag attcagactc tgagggagga gccgctggtg 180 gagaagcaga catggacttc ctgcggaact tattctccca gacgctcagc ctgggcagcc 240 agaaggagcg tctgctggac gagctgacct tggaaggggt ggcccggtac atgcagagcg 300 aacgctgtcg cagagtcatc tgtttggtgg gagctggaat ctccacatcc gcaggcatcc 360 ccgactttcg ctctccatcc accggcctct atgacaacct agagaagtac catcttccct 420 acccagaggc catctttgag atcagctatt tcaagaaaca tccggaaccc ttcttcgccc 480 tcgccaagga actctatcct gggcagttca agccaaccat ctgtcactac ttcatgcgcc 540 tgctgaagga caaggggcta ctcctgcgct gctacacgca gaacatagat accctggagc 600 gaatagccgg gctggaacag gaggacttgg tggaggcgca cggcaccttc tacacatcac 660 actgcgtcag cgccagctgc cggcacgaat acccgctaag ctggatgaaa gagaagatct 720 tctctgaggt gacgcccaag tgtgaagact gtcagagcct ggtgaagcct gatatcgtct 780 tttttggtga gagcctccca gcgcgtttct tctcctgtat gcagtcagac ttcctgaagg 840 tggacctcct cctggtcatg ggtacctcct tgcaggtgca gccctttgcc tccctcatca 900 gcaaggcacc cctctccacc cctcgcctgc tcatcaacaa ggagaaagct ggccagtcgg 960 accctttcct ggggatgatt atgggcctcg gaggaggcat ggactttgac tccaagaagg 1020 cctacaggga cgtggcctgg ctgggtgaat gcgaccaggg ctgcctggcc cttgctgagc 1080 tccttggatg gaagaaggag ctggaggacc ttgtccggag ggagcacgcc agcatagatg 1140 cccagtcggg ggcgggggtc cccaacccca gcacttcagc ttcccccaag aagtccccgc 1200 cacctgccaa ggacgaggcc aggacaacag agagggagaa accccagtga cagctgcatc 1260 tcccaggcgg gatgccgagc tcctcaggga cagctgagcc ccaaccgggc ctggccccct 1320 cttaaccagc agttcttgtc tggggagctc agaacatccc ccaatctctt acagctccct 1380 ccccaaaact ggggtcccag caaccctggc ccccaacccc agcaaatctc taacacctcc 1440 tagaggccaa ggcttaaaca ggcatctcta ccagccccac tgtctctaac cactcctggg 1500 ctaaggagta acctccctca tctctaactg cccccacggg gccagggcta ccccagaact 1560 tttaactctt ccaggacagg gagcttcggg cccccactct gtctcctgcc cccgggggcc 1620 tgtggctaag taaaccatac ctaacctacc ccagtgtggg tgtgggcctc tgaatataac 1680 ccacacccag cgtaggggga gtctgagccg ggagggctcc cgagtctctg ccttcagctc 1740 ccaaagtggg tggtgggccc ccttcacgtg ggacccactt cccatgctgg atgggcagaa 1800 gacattgctt attggagaca aattaaaaac aaaaacaact aacaaaaaaa aaaaaaaaa 1859 <210> 603 <211> 1856 <212> DNA <213> Homo sapiens <400> 603 ggccactagg cacgggacag agcagtcggt gacaggacag agcagtcggt gacgggacac 60 agtggttggt gacgggacag agcggtcggt gacagcctca agggcttcag caccgcgccc 120 atggcagagc cagaccgact cagattcaga ctctgaggga ggagccgctg gtggagaagc 180 agacatggac ttcctgcgga acttattctc ccagacgctc agcctgggca gccagaagga 240 gcgtctgctg gacgagctga ccttggaagg ggtggcccgg tacatgcaga gcgaacgctg 300 tcgcagagtc atctgtttgg tgggagctgg aatctccaca tccgcaggca tccccgactt 360 tcgctctcca tccaccggcc tctatgacaa cctagagaag taccatcttc cctacccaga 420 ggccatcttt gagatcagct atttcaagaa acatccggaa cccttcttcg ccctcgccaa 480 ggaactctat cctgggcagt tcaagccaac catctgtcac tacttcatgc gcctgctgaa 540 ggacaagggg ctactcctgc gctgctacac gcagaacata gataccctgg agcgaatagc 600 cgggctggaa caggaggact tggtggaggc gcacggcacc ttctacacat cacactgcgt 660 cagcgccagc tgccggcacg aatacccgct aagctggatg aaagagaaga tcttctctga 720 ggtgacgccc aagtgtgaag actgtcagag cctggtgaag cctgatatcg tcttttttgg 780 tgagagcctc ccagcgcgtt tcttctcctg tatgcagtca gacttcctga aggtggacct 840 cctcctggtc atgggtacct ccttgcaggt gcagcccttt gcctccctca tcagcaaggc 900 acccctctcc acccctcgcc tgctcatcaa caaggagaaa gctggccagt cggacccttt 960 cctggggatg attatgggcc tcggaggagg catggacttt gactccaaga aggcctacag 1020 ggacgtggcc tggctgggtg aatgcgacca gggctgcctg gcccttgctg agctccttgg 1080 atggaagaag gagctggagg accttgtccg gagggagcac gccagcatag atgcccagtc 1140 gggggcgggg gtccccaacc ccagcacttc agcttccccc aagaagtccc cgccacctgc 1200 caaggacgag gccaggacaa cagagaggga gaaaccccag tgacagctgc atctcccagg 1260 cgggatgccg agctcctcag ggacagctga gccccaaccg ggcctggccc cctcttaacc 1320 agcagttctt gtctggggag ctcagaacat cccccaatct cttacagctc cctccccaaa 1380 actggggtcc cagcaaccct ggcccccaac cccagcaaat ctctaacacc tcctagaggc 1440 caaggcttaa acaggcatct ctaccagccc cactgtctct aaccactcct gggctaagga 1500 gtaacctccc tcatctctaa ctgcccccac ggggccaggg ctaccccaga acttttaact 1560 cttccaggac aggggagctt cgggccccca ctctgtctcc tgcccctggg ggcctgtggc 1620 taagtaaacc atacctaacc taccccagtg tgggtgtggg cctctgaata taaccccaca 1680 cccagcgtag ggggagtctg agccgggagg gctcccgagt ctctgccttc agctcccaaa 1740 gtgggtggtg ggcccccttc acgtgggacc cacttcccat gctggatggg cagaagacat 1800 tgcttattgg agacaaatta aaaacaaaaa caactaacaa aaaaaaaaaa aaaaaa 1856 <210> 604 <211> 1963 <212> DNA <213> Homo sapiens <400> 604 gtgttgtacg aaagcgcgtc tgcggccgca atgtctgctg agagttgtag ttctgtgccc 60 tatcacggcc actcccattt ctggtgccgt cacgggacag agcagtcggt gacaggacag 120 agcagtcggt gacgggacac agtggttggt gacgggacag agcggtcggt gacagcctca 180 agggcttcag caccgcgccc atggcagagc cagacccctc tcaccctctg gagacccagg 240 cagggaaggt gcaggaggct caggactcag attcagactc tgagggagga gccgctggtg 300 gagaagcaga catggacttc ctgcggaact tattctccca gacgctcagc ctgggcagcc 360 agaaggagcg tctgctggac gagctgacct tggaaggggt ggcccggtac atgcagagcg 420 aacgctgtcg cagagtcatc tgtttggtgg gagctggaat ctccacatcc gcaggcatcc 480 ccgactttcg ctctccatcc accggcctct atgacaacct agagaagtac catcttccct 540 acccagaggc catctttgag atcagctatt tcaagaaaca tccggaaccc ttcttcgccc 600 tcgccaagga actctatcct gggcagttca agccaaccat ctgtcactac ttcatgcgcc 660 tgctgaagga caaggggcta ctcctgcgct gctacacgca gaacatagat accctggagc 720 gaatagccgg gctggaacag gaggacttgg tggaggcgca cggcaccttc tacacatcac 780 actgcgtcag cgccagctgc cggcacgaat acccgctaag ctggatgaaa gagaagatct 840 tctctgaggt gacgcccaag tgtgaagact gtcagagcct ggtgaagcct gatatcgtct 900 tttttggtga gagcctccca gcgcgtttct tctcctgtat gcagtcagac ttcctgaagg 960 tggacctcct cctggtcatg ggtacctcct tgcaggtgca gccctttgcc tccctcatca 1020 gcaaggcacc cctctccacc cctcgcctgc tcatcaacaa ggagaaagct ggccagtcgg 1080 accctttcct ggggatgatt atgggcctcg gaggaggcat ggactttgac tccaagaagg 1140 cctacaggga cgtggcctgg ctgggtgaat gcgaccaggg ctgcctggcc cttgctgagc 1200 tccttggatg gaagaaggag ctggaggacc ttgtccggag ggagcacgcc agcatagatg 1260 cccagtcggg ggcgggggtc cccaacccca gcacttcagc ttcccccaag aagtccccgc 1320 cacctgccaa ggacgaggcc aggacaacag agagggagaa accccagtga cagctgcatc 1380 tcccaggcgg gatgccgagc tcctcaggga cagctgagcc ccaaccgggc ctggccccct 1440 cttaaccagc agttcttgtc tggggagctc agaacatccc ccaatctctt acagctccct 1500 ccccaaaact ggggtcccag caaccctggc ccccaacccc agcaaatctc taacacctcc 1560 tagaggccaa ggcttaaaca ggcatctcta ccagccccac tgtctctaac cactcctggg 1620 ctaaggagta acctccctca tctctaactg cccccacggg gccagggcta ccccagaact 1680 tttaactctt ccaggacagg gagcttcggg cccccactct gtctcctgcc cccgggggcc 1740 tgtggctaag taaaccatac ctaacctacc ccagtgtggg tgtgggcctc tgaatataac 1800 ccacacccag cgtaggggga gtctgagccg ggagggctcc cgagtctctg ccttcagctc 1860 ccaaagtggg tggtgggccc ccttcacgtg ggacccactt cccatgctgg atgggcagaa 1920 gacattgctt attggagaca aattaaaaac aaaaacaact aac 1963 <210> 605 <211> 1931 <212> DNA <213> Homo sapiens <400> 605 cgaaagcgcg tctgcggccg caatgtctgc tgagagttgt agttctgtgc cctatcacgg 60 ccactcccat ttctggtgcc gtcacgggac agagcagtcg gtgacaggac agagcagtcg 120 gtgacgggac acagtggttg gtgacgggac agagcggtcg gtgacagcct caagggcttc 180 agcaccgcgc ccatggcaga gccagaccga ctcagattca gactctgagg gaggagccgc 240 tggtggagaa gcagacatgg acttcctgcg gaacttattc tcccagacgc tcagcctggg 300 cagccagaag gagcgtctgc tggacgagct gaccttggaa ggggtggccc ggtacatgca 360 gagcgaacgc tgtcgcagag tcatctgttt ggtgggagct ggaatctcca catccgcagg 420 catccccgac tttcgctctc catccaccgg cctctatgac aacctagaga agtaccatct 480 tccctaccca gaggccatct ttgagatcag ctatttcaag aaacatccgg aacccttctt 540 cgccctcgcc aaggaactct atcctgggca gttcaagcca accatctgtc actacttcat 600 gcgcctgctg aaggacaagg ggctactcct gcgctgctac acgcagaaca tagataccct 660 ggagcgaata gccgggctgg aacaggagga cttggtggag gcgcacggca ccttctacac 720 atcacactgc gtcagcgcca gctgccggca cgaatacccg ctaagctgga tgaaagagaa 780 gatcttctct gaggtgacgc ccaagtgtga agactgtcag agcctggtga agcctgatat 840 cgtctttttt ggtgagagcc tcccagcgcg tttcttctcc tgtatgcagt cagacttcct 900 gaaggtggac ctcctcctgg tcatgggtac ctccttgcag gtgcagccct ttgcctccct 960 catcagcaag gcacccctct ccacccctcg cctgctcatc aacaaggaga aagctggcca 1020 gtcggaccct ttcctgggga tgattatggg cctcggagga ggcatggact ttgactccaa 1080 gaaggcctac agggacgtgg cctggctggg tgaatgcgac cagggctgcc tggcccttgc 1140 tgagctcctt ggatggaaga aggagctgga ggaccttgtc cggagggagc acgccagcat 1200 agatgcccag tcgggggcgg gggtccccaa ccccagcact tcagcttccc ccaagaagtc 1260 cccgccacct gccaaggacg aggccaggac aacagagagg gagaaacccc agtgacagct 1320 gcatctccca ggcgggatgc cgagctcctc agggacagct gagccccaac cgggcctggc 1380 cccctcttaa ccagcagttc ttgtctgggg agctcagaac atcccccaat ctcttacagc 1440 tccctcccca aaactggggt cccagcaacc ctggccccca accccagcaa atctctaaca 1500 cctcctagag gccaaggctt aaacaggcat ctctaccagc cccactgtct ctaaccactc 1560 ctgggctaag gagtaacctc cctcatctct aactgccccc acggggccag ggctacccca 1620 gaacttttaa ctcttccagg acagggagct tcgggccccc actctgtctc ctgcccccgg 1680 gggcctgtgg ctaagtaaac catacctaac ctaccccagt gtgggtgtgg gcctctgaat 1740 ataacccaca cccagcgtag ggggagtctg agccgggagg gctcccgagt ctctgccttc 1800 agctcccaaa gtgggtggtg ggcccccttc acgtgggacc cacttcccat gctggatggg 1860 cagaagacat tgcttattgg agacaaatta aaaacaaaaa caactaacaa aaaaaaaaaa 1920 aaaaaaaaaa a 1931 <210> 606 <211> 2550 <212> DNA <213> Homo sapiens <400> 606 cgaccaagca cagtggctca cgcctgtgat cccggcactt tgggaggccg aggcaggaga 60 cttgcttgag cccaggagtt caagaccacc ctgggcaaca gaggaagacc tcgtctctac 120 aaagcaaaca aacaaacaaa caaaaaatga gcctggcatg gtggcacgtg cctgtggtcc 180 cagctacttg ggaggctgag gtgggaggat cccttgagct tgggaggttg aggctgcagc 240 aagctgtgac tgcaccagtg cactccagcc tgggcaacag agcgagacac tgtctcaaaa 300 aagaaaagca aagcaaagcc actcacatga ggtcttgctc ctggggacgg gcatggccag 360 gactccaacc ccggcagcct gtcccagagc cctggagcta gccccagtgc agtctctcca 420 ccaccccgca cttcctcagg ccaccttcct gccacagcct tttccccaaa cctggtatca 480 ccccctctcc tccctcccta atcccacctc tcgggcctgg ccactccacc ccaccccttc 540 caggactcag attcagactc tgagggagga gccgctggtg gagaagcaga cagtgagtat 600 cttcctggag ggacagggag cagggttctg gggggcgggg ggatttcagg gcaggggtgt 660 gggtgatacc tcctcaactc catcaggagt gacatccaaa gtatgtagca gtgggttggg 720 taccagtgcc agagcaggct cctggaggcc gctggctggg ccgggccttg tgcctttaga 780 tgtgggaggc cgggaacccc agggctgggt gccagggtgc cggagacatc catgcccctg 840 gctgaatgcc cgtcctgccg ctgtctctct tctttccggt cagtggactt cctgcggaac 900 ttattctccc agacgctcag cctgggcagc cagaaggagc gtctgctgga cgagctgacc 960 ttggaagggg tggcccggta catgcagagc gaacgctgtc gcagagtcat ctgtttggtg 1020 ggagctggaa tctccacatc cgcaggcatc cccgactttc gctctccatc caccggcctc 1080 tatgacaacc tagagaagta ccatcttccc tacccagagg ccatctttga gatcagctat 1140 ttcaagaaac atccggaacc cttcttcgcc ctcgccaagg aactctatcc tgggcagttc 1200 aagccaacca tctgtcacta cttcatgcgc ctgctgaagg acaaggggct actcctgcgc 1260 tgctacacgc agaacataga taccctggag cgaatagccg ggctggaaca ggaggacttg 1320 gtggaggcgc acggcacctt ctacacatca cactgcgtca gcgccagctg ccggcacgaa 1380 tacccgctaa gctggatgaa agagaagatc ttctctgagg tgacgctcaa gtgtgaagac 1440 tgtcagagcc tggtgaagcc tgatatcgtc ttttttggtg agagcctccc agcgcgtttc 1500 ttctcctgta tgcagtcaga cttcctgaag gtggacctcc tcctggtcat gggtacctcc 1560 ttgcaggtgc agccctttgc ctccctcatc agcaaggcac ccctctccac ccctcgcctg 1620 ctcatcaaca aggagaaagc tggccagtcg gaccctttcc tggggatgat tatgggcctc 1680 ggaggaggca tggactttga ctccaagaag gcctacaggg acgtggcctg gctgggtgaa 1740 tgcgaccagg gctgcctggc ccttgctgag ctccttggat ggaagaagga gctggaggac 1800 cttgtccgga gggagcacgc cagcatagat gcccagtcgg gggcgggggt ccccaacccc 1860 agcacttcag cttcccccaa gaagtccccg ccacctgcca aggacgaggc caggacaaca 1920 gagagggaga aaccccagtg acagctgcat ctcccaggcg ggatgccgag ctcctcaggg 1980 acagctgagc cccaaccggg cctggccccc tcttaaccag cagttcttgt ctggggagct 2040 cagaacatcc cccaatctct tacagctccc tccccaaaac tggggtccca gcaaccctgg 2100 gcccccaacc ccagcaaatc tctaacacct cctagaggcc aaggcttaaa caggcatctc 2160 taccagcccc actgtctcta accactcctg ggctaaggag taacctccct catctctaac 2220 tgcccccacg gggccagggc taccccagaa cttttaactc ttccaggaca gggagcttcg 2280 ggcccccact ctgtctcctg cccccggggg cctgtggcta agtaaaccat acctaaccta 2340 ccccagtgtg ggtgtgggcc tctgaatata acccacaccc agcgtagggg gagtctgagc 2400 cgggagggct cccgagtctc tgccttcagc tcccaaagtg ggtggtgggc ccccttcacg 2460 tgggacccac ttcccatgct ggatgggcag aagacattgc ttattggaga caaattaaaa 2520 acaaaaacaa ctaaaaaaaa aaaaaaaaaa 2550 <210> 607 <211> 1896 <212> DNA <213> Homo sapiens <400> 607 atcacggcca ctcccatttc tggtgccgtc acgggacaga gcagtcggtg acaggacaga 60 gcagtcggtg acgggacaca gtggttggtg acgggacaga gcggtcggtg acagcctcaa 120 gggcttcagc accgcgccca tggcagagcc agacccctct caccctctgg agacccaggc 180 agggaaggtg caggaggctc aggactcaga ttcagactct gagggaggag ccgctggtgg 240 agaagcagac atggacttcc tgcggaactt attctcccag acgctcagcc tgggcagcca 300 gaaggagcgt ctgctggacg agctgacctt ggaaggggtg gcccggtaca tgcagagcga 360 acgctgtcgc agagtcatct gtttggtggg agctggaatc tccacatgca tccccgactt 420 tcgctctcca tccaccggcc tctatgacaa cctagagaag taccatcttc cctacccaga 480 ggccatcttt gagatcagct atttcaagaa acatccggaa cccttcttcg ccctcgccaa 540 ggaactctat cctgggcagt tcaagccaac catctgtcac tacttcatgc gcctgctgaa 600 ggacaagggg ctactcctgc gctgctacac gcagaacata gataccctgg agcgaatagc 660 cgggctggaa caggaggact tggtggaggc gcacggcacc ttctacacat cacactgcgt 720 cagcgccagc tgccggcacg aatacccgct aagctggatg aaagagaaga tcttctctga 780 ggtgacgccc aagtgtgaag actgtcagag cctggtgaag cctgatatcg tcttttttgg 840 tgagagcctc ccagcgcgtt tcttctcctg tatgcagtca gacttcctga aggtggacct 900 cctcctggtc atgggtacct ccttgcaggt gcagcccttt gcctccctca tcagcaaggc 960 acccctctcc acccctcgcc tgctcatcaa caaggagaaa gctggccagt cggacccttt 1020 cctggggatg attatgggcc tcggaggagg catggacttt gactccaaga aggcctacag 1080 ggacgtggcc tggctgggtg aatgcgacca gggctgcctg gcccttgctg agctccttgg 1140 atggaagaag gagctggagg accttgtccg gagggagcac gccggcatag atgcccagtc 1200 gggggcgggg gtccccaacc ccagcacttc agcttccccc aagaagtccc cgccacctgc 1260 caaggacgag gccaggacaa cagagaggga gaaaccccag tgacagctgc atctcccagg 1320 cgggatgccg agctcctcag ggacagctga gccccaaccg ggcctggccc cctcttaacc 1380 agcagttctt gtctggggag ctcagaacat cccccaatct cttacagctc cctccccaaa 1440 actggggtcc cagcaaccct ggcccccaac cccagcaaat ctctaacgcc tcctagaggc 1500 caaggcttaa acaggcatct ctaccagccc cactgtctct aaccactcct gggctaagga 1560 gtaacctccc tcatctctaa ctgcccccac ggggccaggg ctaccccaga acttttaact 1620 cttccaggac agggagcttc gggcccccac tctgtctcct gcccccgggg gcctgtggct 1680 aagtaaacca tacctaacct accccagtgt gggtgtgggc ctctgaatct aacccacacc 1740 cagcgtaggg ggagtctgag ccgggagggc tcccgagtct ctgccttcag ctcccaaagt 1800 gggtggtggg cccccttcac gtgggaccca cttcccatgc tggatgggca gaagacattg 1860 cttattggag acaaattaaa aacaaaaaca actaac 1896 <210> 608 <211> 1833 <212> DNA <213> Homo sapiens <400> 608 agagcagtcg gtgacaggac agagcagtcg gtgacgggac acagtggttg gtgacgggac 60 agagcggtcg gtgacagcct caagggcttc agcaccgcgc ccatggcaga gcagaccgac 120 tcagattcag actctgaggg aggagccgct ggtggagaag cagacatgga cttcctgcgg 180 aacttattct cccagacgct cagcctgggc agccagaagg agcgtctgct ggacgagctg 240 accttggaag gggtggcccg gtacatgcag agcgaacgct gtcgcagagt catctgtttg 300 gtgggagctg gaatctccac atccgcaggc atccccgact ttcgctctcc atccaccggc 360 ctctatgaca acctagagaa gtaccatctt ccctacccag aggccatctt tgagatcagc 420 tatttcaaga aacatccgga acccttcttc gccctcgcca aggaactcta tcctgggcag 480 tttcaagcca accatctgtc actacttcat gcgcctgctg aaggacaagg ggctactcct 540 gcgctgctac acgcagaaca tagataccct ggagcgaata gccgggctgg aacaggagga 600 cttggtggag gcgcacggca ccttctacac atcacactgc gtcacgccaa ctgccggcac 660 gaatacccgc taagctggat gaaagagaag atcttctctg aggtgacgcc caagtgtgaa 720 gactgtcaga gcctggtgaa gcctgatatc gtcttttttg gtgagagcct cccagcgcgt 780 ttcttctcct gtatgcagtc agacttcctg aaggtggacc tcctcctggt catgggtacc 840 tccttgcagg tgcagccctt tgcctccctc atcagcaagg cacccctctc cacccctcgc 900 ctgctcatca acaaggagaa agctggccag tcggaccctt tcctggggat gattatgggc 960 ctcggaggag gcatggactt tgactccaag aaggcctaca gggacgtggc ctggctgggt 1020 gaatgcgacc agggctgcct ggcccttgct gagctccttg gatggaagaa ggagctggag 1080 gaccttgttc cgaagggagc acgccagcat agatgcccag tcgggggcgg gggtcccaac 1140 cccagcactt cagcttcccc caagaagtcc ccgccacctg ccaaggacga ggccaggaca 1200 acagagaggg agaaacccca gtgacagctg catctcccag gcgggatgcg acgctcctca 1260 gggacagctg agccccaacc gggcctggcc cctcttaacc agcagttctt gtctggggag 1320 ctcagaacat cccccaatct cttacagctc cctccccaaa actggggtcc cagcaaccct 1380 ggcccccaac cccagcaaat ctctaacacc tcctagaggc caaggcttaa acaggcatct 1440 ctaccagccc cactgtctct aaccactcct gggctaagga gtaacctccc tcatctctac 1500 actgcccacg gggccagggc taccccagaa cttttaactc ttccaggaca gggagcttcg 1560 ggcccccact ctgtctcctg cccccggggg cctgtggcta agtaaaccat acctaaccta 1620 ccccagtgtg ggtgtgggcc tctgaatata acccacaccc agcgtagggg gagtctgagc 1680 cgggagggct cccgagtctc tgccttcagc tcccaaagtg ggtggtgggc ccccttcacg 1740 tgggacccac ttcccatgct ggatgggcag aagacattgc ttattggaga caaattaaaa 1800 acaaaaacaa ctaacaaaaa aaaaaaaaaa aaa 1833 <210> 609 <211> 1576 <212> DNA <213> Homo sapiens <400> 609 cagagccaga ccgactcaga ttcagactct gagggaggag ccgctggtgg agaagcagac 60 atggacttcc tgcggaactt attctcccag acgctcagcc tgggcagcca gaaggagcgt 120 ctgctggacg agctgacctt ggaaggggtg gcccggtaca tgcagagcga acgctgtcgc 180 agagtcatct gtttggtggg agctggaatc tccacatccg caggcatccc cgactttcgc 240 tctccatcca ccggcctcta tgacaaccta gagaagtacc atcttcccta cccagaggcc 300 atctttgaga tcagctattt caagaaacat ccggaaccct tcttcgccct cgccaaggaa 360 ctctatcctg ggcagttcaa gccaaccatc tgtcactact tcatgcgcct gctgaaggac 420 aaggggctac tcctgcgctg ctacacgcag aacatagata ccctggagcg aatagccggg 480 ctggaacagg aggacttggt ggaggcgcac ggcaccttct acacatcaca ctgcgtcagc 540 gccagctgcc ggcacgaata cccgctaagc tggatgaaag agaagatctt ctctgaggtg 600 acgcccaagt gtgaagactg tcagagcctg gtgaagcctg atatcgtctt ttttggtgag 660 agcctcccag cgcgtttctt ctcctgtatg cagtcagact tcctgaaggt ggacctcctc 720 ctggtcatgg gtacctcctt gcagggacgt ggcctggctg ggtgaatgcg accagggctg 780 cctggccctt gctgagctcc ttggatggaa gaaggagctg gaggaccttg tccggaggga 840 gcacgccagc atagatgccc agtcgggggc gggggtcccc aaccccagca cttcagcttc 900 ccccaagaag tccccgccac ctgccaagga cgaggccagg acaacagaga gggagaaacc 960 ccagtgacag ctgcatctcc caggcgggat gccgagctcc tcagggacag ctgagcccca 1020 accgggcctg gccccctctt aaccagcagt tcttgtctgg ggagctcaga acatccccca 1080 atctcttaca gctccctccc caaaactggg gtcccagcaa ccctggcccc caaccccagc 1140 aaatctctaa cacctcctag aggccaaggc ttaaacaggc atctctacca gccccactgt 1200 ctctaaccac tcctgggcta aggagtaacc tccctcatct ctaactgccc ccacggggcc 1260 agggctaccc cagaactttt aactcttcca ggacagggag cttcgggccc ccactctgtc 1320 tcctgccccc gggggcctgt ggctaagtaa accataccta acctacccca gtgtgggtgt 1380 gggcctctga atataaccca cacccagcgt agggggagtc tgagccggga gggctcccga 1440 gtctgccttc agctcccaaa gtgggtggtg ggcccccttc acgtgggacc cacttcccat 1500 gctggatggg cagaagacat tgcttattgg agacaaatta aaaacaaaaa caactaacaa 1560 aaaaaaaaaa aaaaaa 1576 <210> 610 <211> 2757 <212> DNA <213> Homo sapiens <400> 610 acagttcctg gcatgcggca gtggcctgtg gctgttccct gcagtcgtca gcagtgctgt 60 cgctcttccc tgcagccaac catctgtcac tacttcatgc gcctgctgaa ggacaagggg 120 ctactcctgc gctgctacac gcaggtaggc ggatgcgagc atcctgggag gaggatgggc 180 gggtggaacg ggcatggtgt cctcagcaga ggagcagagc tgcgtgccca agagctcagg 240 cggggactcc agcaatgcgg ggccagggct tggcctactg cctccttgct gcatgacctg 300 ccgtgagtca cgtcttctct gcctcagttt ccccttccgt caaacagggg ccagaaaagg 360 tttgccctct caggtctgcc ctctcaggtc tgcagtgcgg tggcagtgac ctcctctcag 420 ggccatccca tgtgtgatgt ggaaggagcc tatggctgaa gggactctgt gtgcactata 480 ggcaccccag atttcacatt ggttatgagc gagtttccaa agtgacttca tctaacaaaa 540 tccatacact atgacacgtg tccaacaagt agatgttgtg ccttaaggaa ggggcacctt 600 tttatagttt tttgtgcttt gcccaattat aaacatgtct cgtacacgtc aggtgcttag 660 ccaagggcct ctccctgggg cattcaagca aggatggctc acattgttgg cttctggttt 720 ggagagtctc acacccctaa cagtaaaaaa atcttgatgg gctgggcaca gtggctcaca 780 cctgtaatcc cagcactttg ggaggccaaa gcgagagata gctcgagccc aggcgtttgc 840 gacccgcctg ggcaacatag ggagaccctg tctctacaag aaatacaaaa attagctggg 900 cagggtggcg tgtgcctgta gccccagcta ctcaggaggc tgaggtaggg ggattgcttg 960 agttcaggaa gtcaagactg cagtgagcta tgatggtgcc actgtactgt agcctgggag 1020 acctggtttc aaagaaacaa aaaacaaatc aaaacaacaa caaaatgttg ctgcctctac 1080 ctgttttatg aatatgtata gaaatgacat gatgcactac aacagtatta attcaagctc 1140 tagatcacac ctcagaaccc cgaattataa aacaggtggc cgggcgcggt ggctcacgcc 1200 tgtaatccca gcactttggg acaccgaggt gggcagatca cgaggtcagg agttcaagac 1260 cagcctgtcc aacatcatga aatctggtct ctactaaaaa tacaaaaatt agccaggtgt 1320 ggtggtgcct gtaaccccag ctactcggga ggctgaggca ggagaatcgc ttgaacctgg 1380 gaggcagagg ttgtagtgag tcaagattgt gccactgcac tccagcctgg gtgacagagc 1440 aagactccat ctcaatttaa aaaaacaaac aaacaaacaa aaaagagtgg taacattgaa 1500 aataaataag tgttctagtg ttttctccct gtacctgcag tttggcacct gcagccccaa 1560 aagctaccgc cagggggagg aacaactggc tttaagttca gatttctcag gtgggcgagg 1620 tgttcccacc tggggctggt aggaggcaga gggcagcgga ggcctccttc ttccaagagg 1680 aggagtcctg tgatccccac actttgggag gccgaagtgg gagatcgctt gggcccatga 1740 gttcaagacc agcctgggca acatagggag actccgggct cagaataaac cttctgccca 1800 gagagtcacc attattccag gacgtggctc agatatgata acagcttgct tgaagccaag 1860 tgctttttgt ggttgatgtc atgacactca ccccaagacc ccgctggccc ttgtttgtca 1920 gcttctgtca aagtaaatgt tcactgagtt gattccctac agcagggagg gagatgatgg 1980 acaagatgga gacaccatat actgagcata taagatggtc atgggtccct ggaacacagt 2040 taagctggaa ggggagtcag aaacggtgta tgtgttcggg aaagggggtg ctgttgtaaa 2100 ccccatctct acgaaaaata caaaaattag ccaggcgtgg tggcacatgc ctgtagtcct 2160 agttactcag gaggctgagg catgagagtt gcttgaacct gggaggtgga ggttgccctg 2220 agctgagatt gccccactgc actccagcct gggtgacaga gagagactcc gtctcaaaaa 2280 aagaaaaaaa atgacacatc acatacaaac tattatataa aggccaggcg cggtggctca 2340 cgtctgtaat cccagcactt tgggaggcca aagtcaacgt caggagttta agaccagcct 2400 ggccaacatg gtgaaaccct gtctctacta aaaatacaaa aattagctgg gtgtggtggt 2460 gcgtgcctgt aatcccagct actcaggatg ctgaggcagg agaatcactt aaacctggga 2520 ggcagaggtt gcagtgagcc aagattctgc cattgcactc caacctgggc aacagagcaa 2580 gactccatct caaaaaaaaa aaaaaaaaat tagccaggca tggtagtgca cacctgtagt 2640 cccagctact tgggagcttg agagaggagg attgcttgag cccaggattt caaggctaca 2700 gtgagctatg atcaagctac tgtactccag cctggaccag tagagcaaaa tcctgtc 2757 <210> 611 <211> 769 <212> DNA <213> Homo sapiens <400> 611 ccccccccgc cccccccgcc gccccttggt acttggaaaa atggacaagg attgtgaaat 60 gaaacgcacc acactggaca gccctttggg gaagctggag ctgtctggtt gtgagcaggg 120 tctgcacgaa ataaagctcc tgggcaaggg gacgtctgca gctgatgccg tggaggtccc 180 agcccccgct gcggttctcg gaggtccgga gcccctgatg cagtgcacag cctggctgaa 240 tgcctatttc caccagcccg aggctatcga agagttcccc gtgccggcac ttcaccatcc 300 cgttttccag caagagtcgt tcaccagaca ggtgttatgg aagctgctga aggttgtgaa 360 attcggagaa gtgatttctt accagcaatt agcagccctg gcaggcaacc ccaaagccgc 420 gcgagcagtg ggaggagcaa tgagaggcaa tcctgtcccc atcctcatcc cgtgccacag 480 agtggtctgc agcagcggag ccgtgggcaa ctactccgga ggactggccg tgaaggaatg 540 gcttctggcc catgaaggcc accggttggg gaagccaggc ttgggaggga gctcaggtct 600 ggcaggggcc tggctcaagg gagcgggagc tacctcgggc tccccgcctg ctggccgaaa 660 ctgagtatgt gcagtaggat ggatgtttga gcgacacaca cgtgtaacac tgcatcggat 720 gcggggcgtg gaggcaccgc tgtattaaag gaagtggcag tgtcctggg 769 <210> 612 <211> 769 <212> DNA <213> Homo sapiens <400> 612 ccccccccgc cccccccgcc gccccttggt acttggaaaa atggacaagg attgtgaaat 60 gaaacgcacc acactggaca gccctttggg gaagctggag ctgtctggtt gtgagcaggg 120 tctgcacgaa ataaagctcc tgggcaaggg gacgtctgca gctgatgccg tggaggtccc 180 agcccccgct gcggttctcg gaggtccgga gcccctgatg cagtgcacag cctggctgaa 240 tgcctatttc caccagcccg aggctatcga agagttcccc gtgccggcac ttcaccatcc 300 cgttttccag caagagtcgt tcaccagaca ggtgttatgg aagctgctga aggttgtgaa 360 attcggagaa gtgatttctt accagcaatt agcagccctg gcaggcaacc ccaaagccgc 420 gcgagcagtg ggaggagcaa tgagaggcaa tcctgtcccc atcctcatcc cgtgccacag 480 agtggtctgc agcagcggag ccgtgggcaa ctactccgga ggactggccg tgaaggaatg 540 gcttctggcc catgaaggcc accggttggg gaagccaggc ttgggaggga gctcaggtct 600 ggcaggggcc tggctcaagg gagcgggagc tacctcgggc tccccgcctg ctggccgaaa 660 ctgagtatgt gcagtaggat ggatgtttga gcgacacaca cgtgtaacac tgcatcggat 720 gcggggcgtg gaggcaccgc tgtattaaag gaagtggcag tgtcctggg 769 <210> 613 <211> 744 <212> DNA <213> Homo sapiens <400> 613 ttggtacttg gaaaaatgga caaggattgt gaaatgaaac gcaccacact ggacagccct 60 ttggggaagc tggagctgtc tggttgtgag cagggtctgc acgaaataaa gctcctgggc 120 aaggggacgt ctgcagctga tgccgtggag gtcccagccc ccgctgcggt tctcggaggt 180 ccggagcccc tgatgcagtg cacagcctgg ctgaatgcct atttccacca gcccgaggct 240 atcgaagagt tccccgtgcc ggcacttcac catcccgttt tccagcaaga gtcgttcacc 300 agacaggtgt tatggaagct gctgaaggtt gtgaaattcg gagaagtgat ttcttaccag 360 caattagcag ccctggcagg caaccccaaa gccgcgcgag cagtgggagg agcaatgaga 420 ggcaatcctg tccccatcct catcccgtgc cacagagtgg tctgcagcag cggagccgtg 480 ggcaactact ccggaggact ggccgtgaag gaatggcttc tggcccatga aggccaccgg 540 ttggggaagc caggcttggg agggagctca ggtctggcag gggcctggct caagggagcg 600 ggagctacct cgggctcccc gcctgctggc cgaaactgag tatgtgcagt aggatggatg 660 tttgagcgac acacacgtgt aacactgcat cggatgcggg gcgtggaggc accgctgtat 720 taaaggaagt ggcagtgtcc tggg 744 <210> 614 <211> 797 <212> DNA <213> Homo sapiens <400> 614 gacgcccgca ggtcctcgcg gtgcgcaccg tttgcgactt ggtacttgga aaaatggaca 60 aggattgtga aatgaaacgc accacactgg acagcccttt ggggaagctg gagctgtctg 120 gttgtgagca gggtctgcac gaaataaagc tcctgggcaa ggggacgtct gcagctgatg 180 ccgtggaggt cccagccccc gctgcggttc tcggaggtcc ggagcccctg atgcagtgca 240 cagcctggct gaatgcctat ttccaccagc ccgaggctat cgaagagttc cccgtgccgg 300 ctcttcacca tcccgttttc cagcaagagt cgttcaccag acaggtgtta tggaagctgc 360 tgaaggttgt gaaattcgga gaagtgattt cttaccagca attagcagcc ctggcaggca 420 accccaaagc cgcgcgagca gtgggaggag caatgagagg caatcctgtc cccatcctca 480 tcccgtgcca cagagtggtc tgcagcagcg gagccgtggg caactactcc ggaggactgg 540 ccgtgaagga atggcttctg gcccatgaag gccaccggtt ggggaagcca ggcttgggag 600 ggagctcagg tctggcaggg gcctggctca agggagcggg agctacctcg ggctccccgc 660 ctgctggccg aaactgagta tgtgcagtag gatggatgtt tgagcgacac acacgtgtaa 720 cactgcatcg gatgcggggc gtggaggcac cgctgtatta aaggaagtgg cagtgtcctg 780 ggaaaaaaaa aaaaaaa 797 <210> 615 <211> 835 <212> DNA <213> Homo sapiens <400> 615 gaattcggca cgaggcccgc gcccctagaa cgctttgcgt cccgacgccc gcaggtcctc 60 gcggtgcgca ccgtttgcga cttggtactt ggaaaaatgg acaaggattg tgaaatgaaa 120 cgcaccacac tggacagccc tttggggaag ctggagctgt ctggttgtga gcagggtctg 180 cacgaaataa agctcctggg caaggggacg tctgcagctg atgccgtgga ggtcccagcc 240 cccgctgcgg ttctcggagg tccggagccc ctgatgcagt gcacagcctg gctgaatgcc 300 tatttccacc agcccgaggc tatcgaagag ttccccgtgc cggctcttca ccatcccgtt 360 ttccagcaag agtcgttcac cagacaggtg ttatggaagc tgctgaaggt tgtgaaattc 420 ggagaagtga tttcttacca gcaattagca gccctggcag gcaaccccaa agccgcgcga 480 gcagtgggag gagcaatgag aggcaatcct gtccccatcc tcatcccgtg ccacagagtg 540 gtctgcagca gcggagccgt gggcaactac tccggaggac tggccgtgaa ggaatggctt 600 ctggcccatg aaggccaccg gttggggaag ccaggcttgg gagggagctc aggtctggca 660 ggggcctggc tcaagggagc gggagctacc tcgggctccc cgcctgctgg ccgaaactga 720 gtatgtgcag taggatggat gtttgagcga cacacacgtg taacactgca tcggatgcgg 780 ggcgtggagg caccgctgta ttaaaggaag tggcagtgtc cctcgtgccg aattc 835 <210> 616 <211> 624 <212> DNA <213> Homo sapiens <400> 616 atggacaagg attgtgaaat gaaacgcacc acactggaca gccctttggg gaagctggag 60 ctgtctggtt gtgagcaggg tctgcacgaa ataaagctcc tgggcaaggg gacgtctgca 120 gctgatgccg tggaggtccc agcccccgct gcggttctcg gaggtccgga gcccctgatg 180 cagtgcacag cctggctgaa tgcctatttc caccagcccg aggctatcga agagttcccc 240 gtgccggctc ttcaccatcc cgttttccag caagagtcgt tcaccagaca ggtgttatgg 300 aagctgctga aggttgtgaa attcggagaa gtgatttctt accagcaatt agcagccctg 360 gcaggcaacc ccaaagccgc gcgagcagtg ggaggagcaa tgagaggcaa tcctgtcccc 420 atcctcatcc cgtgccacag agtggtctgc agcagcggag ccgtgggcaa ctactccgga 480 ggactggccg tgaaggaatg gcttctggcc catgaaggcc accggttggg gaagccaggc 540 ttgggaggga gctcaggtct ggcaggggcc tggctcaagg gagcgggagc tacctcgggc 600 tccccgcctg ctggccgaaa ctag 624 <210> 617 <211> 751 <212> DNA <213> Homo sapiens <400> 617 cgagctccag gtacttggaa aaatggacaa ggattgtgaa atgaaacgca ccacactgga 60 cagccctttg gggaagctgg agctgtctgg ttgtgagcag ggtctgcacg aaataaagct 120 cctgggcaag gggacgtctg cagctgatgc cgtggaggtc ccagcccccg ctgcggttct 180 cggaggtccg gagcccctga tgcagtgcac agcctggctg aatgcctatt tccaccagcc 240 cgaggctatc gaagagttcc ccgtgccggc tcttcaccat cccgttttcc agcaagagtc 300 gttcaccaga caggtgttat ggaagctgct gaaggttgtg aaattcggag aagtgatttc 360 ttaccagcaa ttagcagccc tggcaggcaa ccccaaagcc acgcgagcag tgggaggagc 420 aatgagaggc aatcctgtcc ccatcctcat cccgtgccac agagtggtct gcagcagcgg 480 agccgtgggc aactactccg gaggactggc cgtgaaggaa tggcttctgg cccatgaagg 540 ccaccggttg gggaagccag gcttgggagg gagctcaggt ctggcagggg cctggctcaa 600 gggagcggga gctacctcgg gctccccgcc tgctggccga aactgagtat gtgcagtagg 660 atggatgttt gagcgacaca cacgtgtaac actgcatcgg atgcggggcg tggaggcacc 720 gctgtattaa aggaagtggc agtgtcctgg g 751 <210> 618 <211> 1816 <212> DNA <213> Homo sapiens <400> 618 ctcgccttct ggctctgcca tgccctgctc tgaagagaca cccgccattt cacccagtaa 60 gcgggcccgg cctgcggagg tgggcggcat gcagctccgc tttgcccggc tctccgagca 120 cgccacggcc cccacccggg gctccgcgcg cgccgcgggc tacgacctgt acagtgccta 180 tgattacaca ataccaccta tggagaaagc tgttgtgaaa acggacattc agatagcgct 240 cccttctggg tgttatggaa gagtggctcc acggtcaggc ttggctgcaa aacactttat 300 tgatgtagga gctggtgtca tagatgaaga ttatagagga aatgttggtg ttgtactgtt 360 taattttggc aaagaaaagt ttgaagtcaa aaaaggtgat cgaattgcac agctcatttg 420 cgaacggatt ttttatccag aaatagaaga agttcaagcc ttggatgaca ccgaaagggg 480 ttcaggaggt tttggttcca ctggaaagaa ttaaaattta tgccaagaac agaaaacaag 540 aagtcatacc tttttcttaa aaaaaaaaaa aaagtttttg cttcaagtgt tttggtgttt 600 tgcacttctg taaacttact agctttacct tctaaaagta ctgcattttt tacttttttt 660 tatgatcaag gaaaagatcg ttaaaaaaaa acacaaagaa gtttttcttt gtgtttggat 720 caaaaagaaa ctttgttttt ccgcaattga aggttgtatg taaatctgct ttgtggtgac 780 ctgatgtaaa cagtgtcttc ttaaaatcaa atgtaaatca attacagatt aaaaaaaaaa 840 gcctgtattt aactcatatg atctcccttc agcaacttat tttgctttaa ttgctttaaa 900 tcttaagcaa tattttttat tcagtaaaca aattctttca caaggtacaa aatcttgcat 960 aagctgaact aaaataaaaa tgaaaaggag agattaaagg tattccttgt tcttcccttc 1020 tcttcactag tctaaaaact tctttttaat cttaagattc tttgtgatga gggtgagaaa 1080 aagaatcctc agtttatttt tccactatta atctttcttt tgataaatcc tctattgact 1140 gggtagaggt atgtttgtga aagacatgta acttggggat ttgttacttt aggtttgttc 1200 ccttgaattt catctcatca ggcaaattgt actagttgta gttacgagtt ttccctcagt 1260 gaagtagcaa taggctgtaa tcaagaaaat atgccattta tagagataag ataaatgaaa 1320 taatacttca gccaccaggt ttttctgtct cacatacata agcagcattt cattgcagat 1380 atgggactga ttctgtggct taccttgatt aacatctttt ggaagttttg ctagtgtgct 1440 ttcctttctt tactatgttt ctcagattcc tttgtatcag ggttttgggt gtcacttagg 1500 ttttgtccat cagattctgt gagacaccag gcatcgtttt gaggatgtgg gttatacaca 1560 tggagtgctt ctggaactat cagcccactt gaccacccag tttgtggaag cacaggcaag 1620 agtgttcttt tctggtgatt ctccaggcca tttaataccc tgcaatgtaa ttgtccctct 1680 gtggctcaca tttcattagt gagccatgaa atcaactcag tgggacatag ccagcatttt 1740 tgcataccag gttgggctat aaaatatttc tgttgtcaat aaattttaaa tgttttcctg 1800 ctaaaaaaaa aaaaaa 1816 <210> 619 <211> 1816 <212> DNA <213> Homo sapiens <400> 619 ctcgccttct ggctctgcca tgccctgctc tgaagagaca cccgccattt cacccagtaa 60 gcgggcccgg cctgcggagg tgggcggcat gcagctccgc tttgcccggc tctccgagca 120 cgccacggcc cccacccggg gctccgcgcg cgccgcgggc tacgacctgt acagtgccta 180 tgattacaca ataccaccta tggagaaagc tgttgtgaaa acggacattc agatagcgct 240 cccttctggg tgttatggaa gagtggctcc acggtcaggc ttggctgcaa aacactttat 300 tgatgtagga gctggtgtca tagatgaaga ttatagagga aatgttggtg ttgtactgtt 360 taattttggc aaagaaaagt ttgaagtcaa aaaaggtgat cgaattgcac agctcatttg 420 cgaacggatt ttttatccag aaatagaaga agttcaagcc ttggatgaca ccgaaagggg 480 ttcaggaggt tttggttcca ctggaaagaa ttaaaattta tgccaagaac agaaaacaag 540 aagtcatacc tttttcttaa aaaaaaaaaa aaagtttttg cttcaagtgt tttggtgttt 600 tgcacttctg taaacttact agctttacct tctaaaagta ctgcattttt tacttttttt 660 tatgatcaag gaaaagatcg ttaaaaaaaa acacaaagaa gtttttcttt gtgtttggat 720 caaaaagaaa ctttgttttt ccgcaattga aggttgtatg taaatctgct ttgtggtgac 780 ctgatgtaaa cagtgtcttc ttaaaatcaa atgtaaatca attacagatt aaaaaaaaaa 840 gcctgtattt aactcatatg atctcccttc agcaacttat tttgctttaa ttgctttaaa 900 tcttaagcaa tattttttat tcagtaaaca aattctttca caaggtacaa aatcttgcat 960 aagctgaact aaaataaaaa tgaaaaggag agattaaagg tattccttgt tcttcccttc 1020 tcttcactag tctaaaaact tctttttaat cttaagattc tttgtgatga gggtgagaaa 1080 aagaatcctc agtttatttt tccactatta atctttcttt tgataaatcc tctattgact 1140 gggtagaggt atgtttgtga aagacatgta acttggggat ttgttacttt aggtttgttc 1200 ccttgaattt catctcatca ggcaaattgt actagttgta gttacgagtt ttccctcagt 1260 gaagtagcaa taggctgtaa tcaagaaaat atgccattta tagagataag ataaatgaaa 1320 taatacttca gccaccaggt ttttctgtct cacatacata agcagcattt cattgcagat 1380 atgggactga ttctgtggct taccttgatt aacatctttt ggaagttttg ctagtgtgct 1440 ttcctttctt tactatgttt ctcagattcc tttgtatcag ggttttgggt gtcacttagg 1500 ttttgtccat cagattctgt gagacaccag gcatcgtttt gaggatgtgg gttatacaca 1560 tggagtgctt ctggaactat cagcccactt gaccacccag tttgtggaag cacaggcaag 1620 agtgttcttt tctggtgatt ctccaggcca tttaataccc tgcaatgtaa ttgtccctct 1680 gtggctcaca tttcattagt gagccatgaa atcaactcag tgggacatag ccagcatttt 1740 tgcataccag gttgggctat aaaatatttc tgttgtcaat aaattttaaa tgttttcctg 1800 ctaaaaaaaa aaaaaa 1816 <210> 620 <211> 666 <212> DNA <213> Homo sapiens <400> 620 ccacgcgtcc gcccacgcgt ccgcccacgc gtccgcgcgc tccctgcggc gacgctcatc 60 gtgcgctctc ctcttccccc ggtggtctcc tcgctcgcct tctggctctg ccatgccctg 120 ctctgaagag acacccgcca tttcacccag taagcgggcc cggcctgcgg aggtgggcgg 180 catgcagctc cgctttgccc ggctctccga gcacgccacg gcccccaccc ggggctccgc 240 gcgcgccgcg ggctacgacc tgtacagtgc ctatgattac acaataccac ctatggagaa 300 agctgttgtg aaaacggaca ttcagatagc gctcccttct gggtgttatg gaagagtggc 360 tccacggtca ggcttggctg caaaacactt tattgatgta ggagctggtg tcatagatga 420 agattataga ggaaatgttg gtgttgtact gtttaatttt ggcaaagaaa agtttgaagt 480 caaaaaaggt gatcgaattg cacagctcat ttgcgaacgg attttttatc cagaaataga 540 agaagttcaa gccttggatg acaccgaaag gggttcagga ggttttggtt ccactggaaa 600 gaattaaaat ttatgccaag aacagaaaac aagaagtcat acctttttct taaaaaaaaa 660 aaaaaa 666 <210> 621 <211> 885 <212> DNA <213> Homo sapiens <400> 621 ggcacgagct cgctcgcctt ctggctctgc catgccctgc tctgaagaga cacccgccat 60 ttcacccagt aagcgggccc ggcctgcgga ggtgggcggc atgcagctcc gctttgcccg 120 gctctccgag cacgccacgg cccccacccg gggctccgcg cgcgccgcgg gctacgacct 180 gtacagtgcc tatgattaca caataccacc tatggagaaa gctgttgtga aaacggacat 240 tcagatagcg ctcccttctg ggtgttatgg aagagtggct ccacggtcag gcttggctgc 300 aaaacacttt attgatgtag gagctggtgt catagatgaa gattatagag gaaatgttgg 360 tgttgtactg tttaattttg gcaaagaaaa gtttgaagtc aaaaaaggtg atcgaattgc 420 acagctcatt tgcgaacgga ttttttatcc agaaatagaa gaagttcaag ccttggatga 480 caccgaaagg ggttcaggag gttttggttc cactggaaag aattaaaatt tatgccaaga 540 acagaaaaca agaagtcata cctttttctt aaaaaaaaaa aaaaaagttt ttgcttcaag 600 tgttttggtg ttttgcactt ctgtaaactt actagcttta ccttctaaaa gtactgcatt 660 ttttactttt ttttatgatc aaggaaaaga tcattaaaaa aaaacacaaa gaagtttttc 720 tttgtgtttg gatcaaaaag aaactttgtt tttccgcaat tgaaggttgt atgtaaatct 780 gctttgtggt gacctgatgt aaacagtgtc ttcttaaaat caaatgtaaa tcaattacag 840 attaaaaaaa aaagcctgta tttaactcaa aaaaaaaaaa aaaaa 885 <210> 622 <211> 1000 <212> DNA <213> Homo sapiens <400> 622 cgtctcctcg ctcgccttct ggctctgcca tgccctgctc tgaagagaca cccgccattt 60 cacccagtaa gcgggcccgg cctgcggagg tgggcggcat gcagctccgc tttgcccggc 120 tctccgagca cgccacggcc cccacccggg gctccgcgcg cgccgcgggc tacgacctgt 180 acagtgccta tgattacaca ataccaccta tggagaaagc tgttgtgaaa acggacattc 240 agatagcgct cccttctggg tgttatggaa gagtggctcc acggtcaggc ttggctgcaa 300 aacactttat tgatgtagga gctggtgtca tagatgaaga ttatagagga aatgttggtg 360 ttgtactgtt taattttggc aaagaaaagt ttgaagtcaa aaaaggtgat cgaattgcac 420 agctcatttg cgaacggatt ttttatccag aaatagaaga agttcaagcc ttggatgaca 480 ccgaaagggg ttcaggaggt tttggttcca ctggaaagaa ttaaaattta tgccaagaac 540 agaaaacaag aagtcatacc tttttcttaa aaaaaaaaaa agtttttgct tcaagtgttt 600 tggtgttttg cacttctgta aacttactag ctttaccttc taaaagtact gcatttttta 660 ctttttttta tgatcaagga aaagatcatt aaaaaaaaac acaaaagaag tttttctttg 720 tgtttggatc aaaaagaaac tttgtttttc cgcaattgaa ggttgtatgt aaatctgctt 780 tgtggtgacc tgatgtaaac agtgtcttct taaaatcaaa tgtaaatcaa ttacagatta 840 aaaaaaaaaa gcctgtattt aactcatatg atctcccttc agcaacttat tttgctttaa 900 ttgctttaaa tcttaagcaa tattttttat tcagtaaaca aattctttca caaggtacaa 960 aatcttgcat aagctgaact aaaataaaaa tgaaaaggag 1000 <210> 623 <211> 574 <212> DNA <213> Homo sapiens <400> 623 cgctcgcctt ctggctctgc atgccctgcc tctgaagaga cacccgccat ttcacccagt 60 aagcgggccc ggcctgcgag gtgggcggca tgcagctccg ctttgcccgg ctctccgagc 120 acgccacggc ccccacccgg ggctccgcgc gcgccgcggg ctacgacctg tacagtgcct 180 atgattacac aataccacct atggagaaag ctgttgtgaa aacggacatt cagatagcgc 240 tcccttctgg gtgttatgga agagtggctc cacggtcagg cttggctgca aaacacttta 300 ttgatgtagg agctggtgtc atagatgaag attatagagg aaatgttggt gttgtactgt 360 ttaattttgg caaagaaaag tttgaagtca aaaaaggtga tcgaattgca cagctcattt 420 gcgaacggat tttttatcca gaaatagaag aagttcaagc cttggatgac accgaaaggg 480 gttcaggagg ttttggttcc actggaaaga attaaaattt atgccaagaa cagaaaacaa 540 gaagtcatac ctttttctta aaaaaaaaaa aaaa 574 <210> 624 <211> 837 <212> DNA <213> Homo sapiens <400> 624 ctcgccttct ggctctgcat gccctgcctc tgaagagaca cccgccattt cacccagtaa 60 gcgggcccgg cctgcgaggt gggcggcatg cagctccgct ttgcccggct ctccgagcac 120 gccacggccc ccacccgggg ctccgcgcgc gccgcgggct acgacctgta cagtgcctat 180 gattacacaa taccacctat ggagaaagct gttgtgaaaa cggacattca gatagcgctc 240 ccttctgggt gttatggaag agtggctcca cggtcaggct tggctgcaaa acactttatt 300 gatgtaggag ctggtgtcat agatgaagat tatagaggaa atgttggtgt tgtactgttt 360 aattttggca aagaaaagtt tgaagtcaaa aaaggtgatc gaattgcaca gctcatttgc 420 gaacggattt tttatccaga aatagaagaa gttcaagcct tggatgacac cgaaaggggt 480 tcaggaggtt ttggttccac tggaaagaat taaaatttat gccaagaaca gaaaacaaga 540 agtcatacct ttttcttaaa aaaaaaaaaa aagtttttgc ttcaagtgtt ttggtgtttt 600 gcacttctgt aaacttacta gctttacctt ctaaaagtag tgcatttttt ctttttttta 660 tgatcaagga aaagatcatt aaaaaaaaac acaaagaagt ttttctttgt gtttggatca 720 aaaagaaact ttgtttttcc gcaattgaag gttgtatgaa atctgctttg tggtgacctg 780 atgtaaacag tgtcttctta aaatcaaatg taaatcaatt acagattaaa aaaaaaa 837 <210> 625 <211> 599 <212> DNA <213> Homo sapiens <400> 625 agttcccagg acgggcgcgt cttcagggtg gaagcctggc gcacgtccgg agagacaccc 60 gccatttcac ccagtaagcg ggcccggcct gcggaggtgg gcggcatgca gctccgcttt 120 gcccggctct ccgagcacgc cacggccccc acccggggct ccgcgcgcgc cgcgggctac 180 gacctgtaca gtgcctatga ttacacaata ccacctatgg agaaagctgt tgtgaaaacg 240 gacattcaga tagcgctccc ttctgggtgt tatggaagag tggctccacg gtcaggcttg 300 gctgcaaaac actttattga tgtaggagct ggtgtcatag atgaagatta tagaggaaat 360 gttggtgttg tactgtttaa ttttggcaaa gaaaagtttg aagtcaaaaa aggtgatcga 420 attgcacagc tcatttgcga acggattttt tatccagaaa tagaagaagt tcaagccttg 480 gatgacaccg aaaggggttc aggaggtttt ggttccactg gaaagaatta aaatttatgc 540 caagaacaga aaacaagaag tcataccttt ttcttaaaaa aaaaaaaaaa aaaaaaaaa 599 <210> 626 <211> 1653 <212> DNA <213> Homo sapiens <400> 626 ggtggaagcc tggcgcacgt ccggaggtgc cgaggaccca accagcccaa actctggggg 60 aaatgactcc cctctgccct cgccccgcgc tctgctacca tttccttacg tctctgcttc 120 gctcagcgat gcaaaacgcg cgaggcacgg cagagggccg aagccgcggt actctccggg 180 ccaggcccgc ccctcggccg ccggcggcgc agcacgggat tccccggccg ctgtccagcg 240 ctggccgcct gagccaaggc tgccgcggag ccagtacagt cggggccgct ggctggaagg 300 gcgagcttcc taaggcgggg ggaagcccgg cgccggggcc ggagacaccc gccatttcac 360 ccagtaagcg ggcccggcct gcggaggtgg gcggcatgca gctccgcttt gcccggctct 420 ccgagcacgc cacggccccc acccggggct ccgcgcgcgc cgcgggctac gacctgtaca 480 gtgcctatga ttacacaata ccacctatgg agaaagctgt tgtgaaaacg gacattcaga 540 tagcgctccc ttctgggtgt tatggaagag tggctccacg gtcaggcttg gctgcaaaac 600 actttattga tgtaggagct ggtgtcatag atgaagatta tagaggaaat gttggtgttg 660 tactgtttaa ttttggcaaa gaaaagtttg aagtcaaaaa aggtgatcga attgcacagc 720 tcatttgcga acggattttt tatccagaaa tagaagaagt tcaagccttg gatgacaccg 780 aaaggggttc aggaggtttt ggttccactg gaaagaatta aaatttatgc caagaacaga 840 aaacaagaag tcataccttt ttcttaaaaa aaaaaaaagt ttttgcttca agtgttttgg 900 tgttttgcac ttctgtaaac ttactagctt taccttctaa aagtactgca ttttttactt 960 aattagctga agcattgaaa aagcttattt tatctaaggg caaaacacca gctctaaaat 1020 accagcaact ttttgaagat attcggggac aatctgacat agcaattact aaagatatgt 1080 ttgaagaagc actgcgtgcc ctggcagatg atgatttcct gacagtgact gggaagaccg 1140 tgcgcttgct ctgaagcctt gtgagcaagg aaggctccct gcatgtcatg caattctgca 1200 cgccacatgg gtgtggtcat gcaatcatca gttggccgcc atcagtgtaa atagagctta 1260 aagtcatggt ttggctgcat aaaaaatttt ctaacttggg ttcaatattt gtagtgaagt 1320 atctgttttc atttttttca cgttataaat aaaaatacta tgctggccgg gcgcggtggc 1380 tcacacctgt aatcccagca ctttgggagg ccaatgtggg tggatcatga ggtcaggagt 1440 tcaagaccag cctagccaag atggtgaaac cccgtctcta gtaaagataa caaaaaatta 1500 gctgggcttg atggcatgcg cctgtaatcc cagctactcg ggaggttgag gcaggagatc 1560 gcttaaaccc aggcggcaga ggttgcagtg agccaagatc gcgccactgc actccagcct 1620 cagcaataga gtgagactgt ctcaaaaaaa aaa 1653 <210> 627 <211> 4427 <212> DNA <213> Homo sapiens <400> 627 actagttcta gctcgcgatc tagaactagc gacccacgcg tccgggtcca gctgagcctg 60 gtggcggaaa ggctgcggcc ccgcgccaga gggccggtgg ctcctccggg cttctgagga 120 cccgcaggga gcgggcctca tcatttctgt ctcctgtttc tccacttcct tctctattgg 180 ttggtccact gatgtatgga cttgcacatg atgaactgtg aacttctagc cacatgtagt 240 gcccttgggt acttggaggg agacacttac cataaggaac cagattgctt agagagcgtg 300 aaggatctca tccgctattt gaggcatgag gatgagacac gagatgtgcg gcagcagctg 360 ggggcagccc agatcctaca gagcgacctt ctgcccatcc tcacccagca ccaccaggac 420 aagcctctct ttgatgctgt tatcagactg atggtgaact tgacacaacc agccttgctc 480 tgttttggca atctgcctaa ggagcccagc tttcggcacc attttttgca ggtgctaact 540 tatttgcagg cctacaaaga ggcctttgcc agtgagaagg cttttggagt cctcagtgaa 600 accttgtatg agctgctgca gctgggctgg gaggaacggc aggaggaaga caacttgctg 660 attgaacgga tcctactgct ggtcagaaat attctccatg tcccagctga ccttgatcag 720 gagaagaaga ttgatgatga cgccagtgcc catgaccagc tcctctgggc gattcacctc 780 agcggcctgg atgacctgct cctctttctg gccagctcgt ctgctgagga gcaatggagc 840 ctacatgtgc tagagattgt ctcccttatg tttcgtgacc agaaccccga gcagctggcg 900 ggagtagggc agggacgctt agctcaggag cggagtgcag attttgcaga actggaggtg 960 ttgcgccagc gagagatggc agaaaagaag actcgagccc tccagcgagg caacaggcat 1020 tctcgatttg ggggctccta tattgtccag gggttgaaat ccattgggga gagggacctc 1080 atctttcaca aaggccttca caacctacga aactacagtt cagatttggg aaagcagccg 1140 aaaaaggtgc ctaaacgtcg ccaggccgcc cgagagctgt ccattcagcg ccgttctgcc 1200 ctcaatgtga ggctcttcct cagagacttc tgctctgagt tcctggagaa ctgttacaac 1260 cggctcatgg gatcagtaaa ggatcacctg cttcgggaga aagctcagca gcatgatgag 1320 acctattata tgtgggcctt ggctttcttc atggccttca accgagctgc ctccttccgg 1380 ccaggcctgg tttctgagac cctcagtgtc cgtaccttcc acttcattga gcagaacctc 1440 accaactact atgagatgat gctgactgac cgcaaggaag ctgcctcctg ggcacgccgg 1500 atgcacttgg ctctgaaggc ctatcaggag ctgctggcaa cagtgaatga gatggacata 1560 tctccagatg aggctgtgag ggagagcagc cgcatcatca agaacaatat tttctatgtg 1620 atggagtacc gagaactatt cctggcactt tttcgaaagt ttgatgagag atgccagccc 1680 cgctctttcc ttcgtgacct ggtggagacc acccacctct tcctcaaaat gttggagcga 1740 ttctgtcgga gccgtgggaa cctggtggtg cagaacaaac aaaagaagag aaggaagaag 1800 aagaagaagg tcctagacca ggccattgtt tctggtaatg tcccatctag cccagaagaa 1860 gtggaggctg tgtggccagc cctggctgag cagctacagt gctgtgccca gaattctgag 1920 ctcagcatgg actccgtggt tccctttgat gcggcctcag aggtgccagt ggaggagcag 1980 cgggcagaag ctatggtacg gatccaagac tgtctcctgg ctggccaggc cccacaggcc 2040 ctgactctcc tgaggtctgc tcgggaggtg tggcctgaag gagatgtgtt tggctctcaa 2100 gacatttctc cagaggaaga gatccagttg ctgaaacaaa tcctctctgc tccacttccc 2160 cggcagcagg gcccagagga acgtggggca gaggaagaag aagaggagga ggaggaggaa 2220 gaggaggagt tgcaagtggt ccaggtgtcg gagaaagaat ttaattttct ggactacctg 2280 aaacgctttg catgttcaac tgtcgttcga gcctatgtgc tgctactaag gagctaccag 2340 cagaatagtg cccacactaa ccattgcatt gtgaagatgc tgcaccggct ggcccatgac 2400 ctcaaaatgg aagccctact ttttcagctg tcagtcttct gcctcttcaa tcgtctgctt 2460 agtgaccctg ctgctggagc ctacaaagag ctagtgactt ttgccaaata catcctgggc 2520 aaattttttg cactggctgc agtcaaccaa aaagcctttg tggagctgtt gttctggaag 2580 aacacagctg tggttcgaga gatgactgag ggctatggct ccctggatga caggtcttcc 2640 agtcgcagag cacctacatg gagccccgaa gaagaggctc atcttcggga gctgtacctc 2700 gccaataagg acgtggaagg gcaggatgtg gtggaagcca tcttggccca cctgaatact 2760 gttcctcgaa cacgcaagca gatcatccac catctggtac agatgggact ggctgacagt 2820 gtcaaggact tccaaaggaa aggaacccat attgtactgt ggacggggga tcaggagttg 2880 gagctgcagc ggctttttga ggaattccgg gactcagatg atgtcctggg tcatatcatg 2940 aagaatatca cagccaaacg ctcacgggcc cgaatagtgg ataaactctt ggctctgggg 3000 ctggtggctg agcggcggga gctgtacaag aaacggcaga aaaagttggc atcctccatc 3060 ttgccaaatg gagcggagtc cctgaaagat ttttgccagg aagatctgga agaagaggaa 3120 aacctgcctg aggaagacag cgaagaggaa gaagaagggg gctcagaagc agaacaagtc 3180 cagggtagct tagtcctttc aaatgaaaac cttggtcaaa gcctgcatca ggaaggcttt 3240 tctatcctgc tcctatggct ccagaactgc ctgatccgag cagctgatga tcgggaagag 3300 gatggctgct cccaggccgt tccattggtg ccactcacag aggaaaatga ggaagccatg 3360 gaaaacgaac agtttcagca gctgttgcgc aagctagggg ttcggccccc tgcctctggg 3420 caggaaacct tctggcgaat tccagccaag ctgagtccta cccagctccg gagggcagca 3480 gcttctttga gtcaaccaga ggaggaacag aagctgcagc cagagctgca gcctaaagtc 3540 cctggagagc aaggctctga tgaggagcac tgtaaagagc accgagcaca agccctgagg 3600 gccctcttgc tagcccacaa gaagaaagcg ggcctggcat ccccagagga ggaagacgct 3660 gttggtaaag agccgctgaa ggcagcaccc aagaaacgac aattgctgga cagcgacgag 3720 gaacaggaag aagatgaggg caggaacaga gcaccagagt tgggagctcc aggaatccaa 3780 aagaagaaac gataccagat tgaggatgat gaggatgact gaagagctaa gaagcctagg 3840 ggtagagata gacacgtttt tagatggtgc attcaagtca gagttggaag ggtcatacag 3900 gacccagaag ctcctcttac tggacagagc agtagaatcc caggctcttt cacggattta 3960 ggctgagaaa cttcagcagc agtattggac ttctctgctg tcagtctttg tttctcccag 4020 tttttatcgg tatgccccag cagctctctg gagatttagt tctcttcttc taggaaccat 4080 ttcttttggt tattggagct ccttagcaaa taagaggagt gagtgaaata gagaaagcac 4140 cccggacccc ttttattggt ctgttccttt ggctttctct tggaggtggg tcgcagcacc 4200 agatggggag ctttatgaca tgacaggcgg gagttttgta ccacttttag aagataccag 4260 atgcctctgt cctcattttg tttcctatga tcatcctcta gataccagat agaggcccat 4320 tcctgcattt gagatagggt tggaatatag tactctagat gatgaatgtg tttgctttgt 4380 gtttggtatt aaacatgtaa gattagaagt tcaaaaaaaa aaaaaaa 4427 <210> 628 <211> 4366 <212> DNA <213> Homo sapiens <400> 628 cggaaaggct gcggccccgc gccagagggc cggtggctcc tccgggcttc tgaggacccg 60 cagggagcgg gcctcatcat ttctgtctcc tgtttctcca cttccttctc tattggttgg 120 tccactgatg tatggacttg cacatgatga actgtgaact tctagccaca tgtagtgccc 180 ttgggtactt ggagggagac acttaccata aggaaccaga ttgcttagag agcgtgaagg 240 atctcatccg ctatttgagg catgaggatg agacacgaga tgtgcggcag cagctggggg 300 cagcctagat cctacagagc gaccttctgc ccatcctcac ccagcaccac caggacaagc 360 ctctctttga tgctgttatc agactgatgg tgaacttgac acaaccagcc ttgctctgtt 420 ttggcaatct gcctaaggag cccagctttc ggcaccattt tttgcaggtg ctaacttatt 480 tgcaggccta caaagaggcc tttgccagtg agaaggcttt tggagtcctc agtgaaacct 540 tgtatgagct gctgcagctg ggctgggagg aacggcagga ggaagacaac ttgctgattg 600 aacggatcct actgctggtc agaaatattc tccatgtccc agctgacctt gatcaggaga 660 agaagattga tgatgacgcc agtgcccatg accagctcct ctgggcgatt cacctcagcg 720 gcctggatga cctgctcctc tttctggcca gctcgtctgc tgaggagcaa tggagcctac 780 atgtgctaga gattgtctcc cttatgtttc gtgaccagaa ccccgagcag ctggcgggag 840 tagggcaggg acgcttagct caggagcgga gtgcagattt tgcagaactg gaggtgttgc 900 gccagcgaga gatggcagaa aagaagactc gagccctcca gcgaggcaac aggcattctc 960 gatttggggg ctcctatatt gtccaggggt tgaaatccat tggggagagg gacctcatct 1020 ttcacaaagg ccttcacaac ctacgaaact acagttcaga tttgggaaag cagccgaaaa 1080 aggtgcctaa acgtcgccag gccgcccgag agctgtccat tcagcgccgt tctgccctca 1140 atgtgaggct cttcctcaga gacttctgct ctgagttcct ggagaactgt tacaaccggc 1200 tcatgggatc agtaaaggat cacctgcttc gggagaaagc tcagcagcat gatgagacct 1260 attatatgtg ggccttggct ttcttcatgg ccttcaaccg agctgcctcc ttccggccag 1320 gcctggtttc tgagaccctc agtgtccgta ccttccactt cattgagcag aacctcacca 1380 actactatga gatgatgctg actgaccgca aggaagctgc ctcctgggca cgccggatgc 1440 acttggctct gaaggcctat caggagctgc tggcaacagt gaatgagatg gacatatctc 1500 cagatgaggc tgtgagggag agcagccgca tcatcaagaa caatattttc tatgtgatgg 1560 agtaccgaga actattcctg gcactttttc gaaagtttga tgagagatgc cagccccgct 1620 ctttccttcg tgacctggtg gagaccaccc acctcttcct caaaatgttg gagcgattct 1680 gtcggagccg tgggaacctg gtggtgcaga acaaacaaaa gaagagaagg aagaagaaga 1740 agaaggtcct agaccaggcc attgtttctg gtaatgtccc atctagccca gaagaagtgg 1800 aggctgtgtg gccagccctg gctgagcagc tacagtgctg tgcccagaat tctgagctca 1860 gcatggactc cgtggttccc tttgatgcgg cctcagaggt gccagtggag gagcagcggg 1920 cagaagctat ggtacggatc caagactgtc tcctggctgg ccaggcccca caggccctga 1980 ctctcctgag gtctgctcgg gaggtgtggc ctgaaggaga tgtgtttggc tctcaagaca 2040 tttctccaga ggaagagatc cagttgctga aacaaatcct ctctgctcca cttccccggc 2100 agcagggccc agaggaacgt ggggcagagg aagaagaaga ggaggaggag gaggaagagg 2160 aggagttgca agtggtccag gtgtcggaga aagaatttaa ttttctggac tacctgaaac 2220 gctttgcatg ttcaactgtc gttcgagcct atgtgctgct actaaggagc taccagcaga 2280 atagtgccca cactaaccat tgcattgtga agatgctgca ccggctggcc catgacctca 2340 aaatggaagc cctacttttt cagctgtcag tcttctgcct cttcaatcgt ctgcttagtg 2400 accctgctgc tggagcctac aaagagctag tgacttttgc caaatacatc ctgggcaaat 2460 tttttgcact ggctgcagtc aaccaaaaag cctttgtgga gctgttgttc tggaagaaca 2520 cagctgtggt tcgagagatg actgagggct atggctccct ggatgacagg tcttccagtc 2580 gcagagcacc tacatggagc cccgaagaag aggctcatct tcgggagctg tacctcgcca 2640 ataaggacgt ggaagggcag gatgtggtgg aagccatctt ggcccacctg aatactgttc 2700 ctcgaacacg caagcagatc atccaccatc tggtacagat gggactggct gacagtgtca 2760 aggacttcca aaggaaagga acccatattg tactgtggac gggggatcag gagttggagc 2820 tgcagcggct ttttgaggaa ttccgggact cagatgatgt cctgggtcat atcatgaaga 2880 atatcacagc caaacgctca cgggcccgaa tagtggataa actcttggct ctggggctgg 2940 tggctgagcg gcgggagctg tacaagaaac ggcagaaaaa gttggcatcc tccatcttgc 3000 caaatggagc ggagtccctg aaagattttt gccaggaaga tctggaagaa gaggaaaacc 3060 tgcctgagga agacagcgaa gaggaagaag aagggggctc agaagcagaa caagtccagg 3120 gtagcttagt cctttcaaat gaaaaccttg gtcaaagcct gcatcaggaa ggcttttcta 3180 tcctgctcct atggctccag aactgcctga tccgagcagc tgatgatcgg gaagaggatg 3240 gctgctccca ggccgttcca ttggtgccac tcacagagga aaatgaggaa gccatggaaa 3300 acgaacagtt tcagcagctg ttgcgcaagc taggggttcg gccccctgcc tctgggcagg 3360 aaaccttctg gcgaattcca gccaagctga gtcctaccca gctccggagg gcagcagctt 3420 ctttgagtca accagaggag gaacagaagc tgcagccaga gctgcagcct aaagtccctg 3480 gagagcaagg ctctgatgag gagcactgta aagagcaccg agcacaagcc ctgagggccc 3540 tcttgctagc ccacaagaag aaagcgggcc tggcatcccc agaggaggaa gacgctgttg 3600 gtaaagagcc gctgaaggca gcacccaaga aacgacaatt gctggacagc gacgaggaac 3660 aggaagaaga tgagggcagg aacagagcac cagagttggg agctccagga atccaaaaga 3720 agaaacgata ccagattgag gatgatgagg atgactgaag agctaagaag cctaggggta 3780 gagatagaca cgtttttaga tggtgcattc aagtcagagt tggaagggtc atacaggacc 3840 cagaagctcc tcttactgga cagagcagta gaatcccagg ctctttcacg gatttaggct 3900 gagaaacttc agcagcagta ttggacttct ctgctgtcag tctttgtttc tcccagtttt 3960 tatcggtatg ccccagcagc tctctggaga tttagttctc ttcttctagg aaccatttct 4020 tttggttatt ggagctcctt agcaaataag aggagtgagt gaaatagaga aagcaccccg 4080 gacccctttt attggtctgt tcctttggct ttctcttgga ggtgggtcgc agcaccagat 4140 ggggagcttt atgacatgac aggcgggagt tttgtaccac ttttagaaga taccagatgc 4200 ctctgtcctc attttgtttc ctatgatcat cctctagata ccagatagag gcccattcct 4260 gcatttgaga tagggttgga atatagtact ctagatgatg aatgtgtttg ctttgtgttt 4320 ggtattaaac atgtaagatt agaagttctc aaaaaaaaaa aaaaaa 4366 <210> 629 <211> 3627 <212> DNA <213> Homo sapiens <400> 629 atggacttgc acatgatgaa ctgtgaactt ctagccacat gtagtgccct tgggtacttg 60 gagggagaca cttaccataa ggaaccagat tgcttagaga gcgtgaagga tctgatccgc 120 tatttgaggc atgaggatga gacacgagat gtgcggcagc agctgggggc agcccagatc 180 ctacagagcg accttctgcc catcctcacc cagcaccacc aggacaagcc tctctttgat 240 gctgttatca gactgatggt gaacttgaca caaccagcct tgctctgttt tggcaatctg 300 cctaaggagc ccagctttcg gcaccatttt ttgcaggtgc taacttattt gcaggcctac 360 aaagaggcct ttgccagtga gaaggctttt ggagtcctca gtgaaacctt gtatgagctg 420 ctgcagctgg gctgggagga acggcaggag gaagacaact tgctgattga acggatccta 480 ctgctggtca gaaatattct ccatgtccca gctgaccttg atcaggagaa gaagattgat 540 gatgacgcca gtgcccatga ccagctcctc tgggcgattc acctcagcgg cctggatgac 600 ctgctcctct ttctggccag ctcgtctgct gaggagcaat ggagcctaca tgtgctagag 660 attgtctccc ttatgtttcg tgaccagaac cccgagcagc tggcgggagt agggcaggga 720 cgcttagctc aggagcggag tgcagatttt gcagaactgg aggtattgcg ccagcgagag 780 atggcagaaa agaagactcg agccctccag cgaggcaaca ggcattctcg atttgggggc 840 tcctatattg tccaggggtt gaaatccatt ggggagaggg acctcatctt tcacaaaggc 900 cttcacaacc tacgaaacta cagttcagat ttgggaaagc agccgaaaaa ggtgcctaaa 960 cgtcgccagg ccgcccgaga gctgtccatt cagcgccgtt ctgccctcaa tgtgaggctc 1020 ttcctcagag acttctgctc tgagttcctg gagaactgtt acaaccggct catgggatca 1080 gtaaaggatc acctgcttcg ggagaaagct cagcagcatg atgagaccta ttatatgtgg 1140 gccttggctt tcttcatggc cttcaaccga gctgcctcct tccggccagg cctggtttct 1200 gagaccctca gtgtccgtac cttccacttc attgagcaga acctcaccaa ctactatgag 1260 atgatgctga ctgaccgcaa ggaagctgcc tcctgggcac gccggatgca cttggctctg 1320 aaggcctatc aggagctgct ggcaacagtg aatgagatgg acttatctcc agatgaggct 1380 gtgagggaga gcagccgcat catcaagaac aatattttct atgtgatgga gtaccgagaa 1440 ctattcctgg cactttttcg aaagtttgat gagagatgcc agccccgctc tttccttcgt 1500 gacctggtgg agaccaccca cctcttcctc aaaatgttgg agcgattctg tcggagccgt 1560 gggaacctgg tggtgcagaa caaacaaaag aagagaagga agaagaagaa gaaggtccta 1620 gaccaggcca ttgtttctgg taatgtccca tctagcccag aagaagtgga ggctgtgtgg 1680 ccagccctgg ctgagcagct acagtgctgt gcccagaatt ctgagctcag catggactcc 1740 gtggttccct ttgatgcggc ctcagaggtg ccagtggagg agcagcgggc agaagctatg 1800 gtacggatcc aagactgtct cctggctggc caggccccac aggccctgac tctcctgagg 1860 tctgctcggg aggtgtggcc tgaaggagat gtgtttggct ctcaagacat ttctccagag 1920 gaagagatcc agttgctgaa acaaatcctc tctgctccac ttccccggca gcagggccca 1980 gaggaacgtg gggcagagga agaagaagag gaggaggagg aggaagagga ggagttgcaa 2040 gtggtccagg tgtcggagaa agaatttaat tttctggact acctgaaacg ctttgcatgt 2100 tcaactgtcg ttcgagccta tgtgctgcta ctaaggagct accagcagaa tagtgcccac 2160 actaaccatt gcattgtgaa gatgctgcac cggctggccc atgacctcaa aatggaagcc 2220 ctactttttc agctgtcagt cttctgcctc ttcaatcgtc tgcttagtga ccctgctgct 2280 ggagcctaca aagagctagt gacttttgcc aaatacatcc tgggcaaatt ttttgcactg 2340 gctgcagtca accaaaaagc ctttgtggag ctgttgttct ggaagaacac agctgtggtt 2400 cgagagatga ctgagggcta tggctccctg gatgacaggt cttccagtcg cagagcacct 2460 acatggagcc ccgaagaaga ggctcatctt crggagctgt acctcgccaa taaggacgtg 2520 gaagggcagg atgtggtgga agccatcttg gcccacctga atactgttcc tcgaacacgc 2580 aagcagatca tccaccatct ggtacagatg ggactggctg acagtgtcaa ggacttccaa 2640 aggaaaggaa cccatattgt actgtggacg ggggatcagg agttggagct gcagcggctt 2700 tttgaggaat tccgggactc agatgatgtc ctgggtcata tcatgaagaa tatcacagcc 2760 aaacgctcac gggcccgaat agtggataaa ctcttggctc tggggctggt ggctgagcgg 2820 cgggagctgt acaagaaacg gcagaaaaag ttggcatcct ccatcttgcc aaatggagcg 2880 gagtccctga aagatttttg ccaggaagat ctggaagaag aggaaaacct gcctgaggaa 2940 gacagcgaag aggaagaaga agggggctca gaagcagaac aagtccaggg tagcttagtc 3000 ctttcaaatg aaaaccttgg tcaaagcctg catcaggaag gcttttctat ccygctccta 3060 tggctccaga actgcctgat ccgagcagct gatgatcggg aagaggatgg ctgctcccag 3120 gccgttccat tggtgccact cacagaggaa aatgaggaag ccatggaaaa cgaacagttt 3180 cagcagctgt tgcgcaagct aggggttcgg ccccctgcct ctgggcagga aaccttctgg 3240 cgaattccag ccaagctgag tcctacccag ctccggaggg cagcagcttc tttgagtcaa 3300 ccagaggagg aacagaagct gcagccagag ctgcagccta aagtccctgg agagcaaggc 3360 tctgatgagg agcactgtaa agagcaccga gcacaagccc tgagggccct cttgctagcc 3420 cacaagaaga aagcgggcct ggcatcccca gaggaggaag acgctgttgg taaagagccg 3480 ctgaaggcag cacccaagaa acgacaattg ctggacagcg acgaggaaca ggaagaagat 3540 gagggcagga acagagcacc agagttggga gctccaggaa tccaaaagaa gaaacgatac 3600 cagattgagg atgatgagga tgactga 3627 <210> 630 <211> 4417 <212> DNA <213> Homo sapiens <400> 630 ggcacgagtg gcggaaaggc tgcggccccg cgccagaggg ccggtggctc ctccgggctt 60 ctgaggaccc gcagggagcg ggcctcatca tttctgtctc ctgtttctcc acttccttct 120 ctattggttg gtccactgat gtatggactt gcacatgatg aactgtgaac ttctagccac 180 atgtagtgcc cttgggtact tggagggaga cacttaccat aaggaaccag attgcttaga 240 gagcgtgaag gatctgatcc gctatttgag gcatgaggat gagacacgag atgtgcggca 300 gcagctgggg gcagcccaga tcctacagag cgaccttctg cccatcctca cccagcacca 360 ccaggacaag cctctctttg atgctgttat cagactgatg gtgaacttga cacaaccagc 420 cttgctctgt tttggcaatc tgcctaagga gcccagcttt cggcaccatt ttttgcaggt 480 gctaacttat ttgcaggcct acaaagaggc ctttgccagt gagaaggctt ttggagtcct 540 cagtgaaacc ttgtatgagc tgctgcagct gggctgggag gaacggcagg aggaagacaa 600 cttgctgatt gaacggatcc tactgctggt cagaaatatt ctccatgtcc cagctgacct 660 tgatcaggag aagaagattg atgatgacgc cagtgcccat gaccagctcc tctgggcgat 720 tcacctcagc ggcctggatg acctgctcct ctttctggcc agctcgtctg ctgaggagca 780 atggagccta catgtgctag agattgtctc ccttatgttt cgtgaccaga accccgagca 840 gctggcggga gtagggcagg gacgcttagc tcaggagcgg agtgcagatt ttgcagaact 900 ggaggtattg cgccagcgag agatggcaga aaagaagact cgagccctcc agcgaggcaa 960 caggcattct cgatttgggg gctcctatat tgtccagggg ttgaaatcca ttggggagag 1020 ggacctcatc tttcacaaag gccttcacaa cctacgaaac tacagttcag atttgggaaa 1080 gcagccgaaa aaggtgccta aacgtcgcca ggccgcccga gagctgtcca ttcagcgccg 1140 ttctgccctc aatgtgaggc tcttcctcag agacttctgc tctgagttcc tggagaactg 1200 ttacaaccgg ctcatgggat cagtaaagga tcacctgctt cgggagaaag ctcagcagca 1260 tgatgagacc tattatatgt gggccttggc tttcttcatg gccttcaacc gagctgcctc 1320 cttccggcca ggcctggttt ctgagaccct cagtgtccgt accttccact tcattgagca 1380 gaacctcacc aactactatg agatgatgct gactgaccgc aaggaagctg cctcctgggc 1440 acgccggatg cacttggctc tgaaggccta tcaggagctg ctggcaacag tgaatgagat 1500 ggacttatct ccagatgagg ctgtgaggga gagcagccgc atcatcaaga acaatatttt 1560 ctatgtgatg gagtaccgag aactattcct ggcacttttt cgaaagtttg atgagagatg 1620 ccagccccgc tctttccttc gtgacctggt ggagaccacc cacctcttcc tcaaaatgtt 1680 ggagcgattc tgtcggagcc gtgggaacct ggtggtgcag aacaaacaaa agaagagaag 1740 gaagaagaag aagaaggtcc tagaccaggc cattgtttct ggtaatgtcc catctagccc 1800 agaagaagtg gaggctgtgt ggccagccct ggctgagcag ctacagtgct gtgcccagaa 1860 ttctgagctc agcatggact ccgtggttcc ctttgatgcg gcctcagagg tgccagtgga 1920 ggagcagcgg gcagaagcta tggtacggat ccaagactgt ctcctggctg gccaggcccc 1980 acaggccctg actctcctga ggtctgctcg ggaggtgtgg cctgaaggag atgtgtttgg 2040 ctctcaagac atttctccag aggaagagat ccagttgctg aaacaaatcc tctctgctcc 2100 acttccccgg cagcagggcc cagaggaacg tggggcagag gaagaagaag aggaggagga 2160 ggaggaagag gaggagttgc aagtggtcca ggtgtcggag aaagaattta attttctgga 2220 ctacctgaaa cgctttgcat gttcaactgt cgttcgagcc tatgtgctgc tactaaggag 2280 ctaccagcag aatagtgccc acactaacca ttgcattgtg aagatgctgc accggctggc 2340 ccatgacctc aaaatggaag ccctactttt tcagctgtca gtcttctgcc tcttcaatcg 2400 tctgcttagt gaccctgctg ctggagccta caaagagcta gtgacttttg ccaaatacat 2460 cctgggcaaa ttttttgcac tggctgcagt caaccaaaaa gcctttgtgg agctgttgtt 2520 ctggaagaac acagctgtgg ttcgagagat gactgagggc tatggctccc tggatgacag 2580 gtcttccagt cgcagagcac ctacatggag ccccgaagaa gaggctcatc ttcaggagct 2640 gtacctcgcc aataaggacg tggaagggca ggatgtggtg gaagccatct tggcccacct 2700 gaatactgtt cctcgaacac gcaagcagat catccaccat ctggtacaga tgggactggc 2760 tgacagtgtc aaggacttcc aaaggaaagg aacccatatt gtactgtgga cgggggatca 2820 ggagttggag ctgcagcggc tttttgagga attccgggac tcagatgatg tcctgggtca 2880 tatcatgaag aatatcacag ccaaacgctc acgggcccga atagtggata aactcttggc 2940 tctggggctg gtggctgagc ggcgggagct gtacaagaaa cggcagaaaa agttggcatc 3000 ctccatcttg ccaaatggag cggagtccct gaaagatttt tgccaggaag atctggaaga 3060 agaggaaaac ctgcctgagg aagacagcga agaggaagaa gaagggggct cagaagcaga 3120 acaagtccag ggtagcttag tcctttcaaa tgaaaacctt ggtcaaagcc tgcatcagga 3180 aggcttttct atcccgctcc tatggctcca gaactgcctg atccgagcag ctgatgatcg 3240 ggaagaggat ggctgctccc aggccgttcc attggtgcca ctcacagagg aaaatgagga 3300 agccatggaa aacgaacagt ttcagcagct gttgcgcaag ctaggggttc ggccccctgc 3360 ctctgggcag gaaaccttct ggcgaattcc agccaagctg agtcctaccc agctccggag 3420 ggcagcagct tctttgagtc aaccagagga ggaacagaag ctgcagccag agctgcagcc 3480 taaagtccct ggagagcaag gctctgatga ggagcactgt aaagagcacc gagcacaagc 3540 cctgagggcc ctcttgctag cccacaagaa gaaagcgggc ctggcatccc cagaggagga 3600 agacgctgtt ggtaaagagc cgctgaaggc agcacccaag aaacgacaat tgctggacag 3660 cgacgaggaa caggaagaag atgagggcag gaacagagca ccagagttgg gagctccagg 3720 aatccaaaag aagaaacgat accagattga ggatgatgag gatgactgaa gagctaagaa 3780 gcctaggggt agagatagac acgtttttag atggtgcatt caagtcagag ttggaagggt 3840 catacaggac ccagaagctc ctcttactgg acagagcagt agaatcccag gctctttcac 3900 ggatttaggc tgagaaactt cagcagcagt attggacttc tctgctgtca gtctttgttt 3960 ctcccagttt ttatcggtat gccccagcag ctctctggag atttagttct cttcttctag 4020 gaaccatttc ttttggttat tggagctcct tagcaaataa gaggagtgag tgaaatagag 4080 aaagcacccc ggaccccttt tattggtctg ttcctttggc tttctcttgg aggtgggtcg 4140 cagcaccaga tggggagctt tatgacatga caggcgggag ttttgtacca cttttagaag 4200 ataccagatg cctctgtcct cattttgttt cctatgatca tcctctagat accagataga 4260 ggcccattcc tgcatttgag atagggttgg aatatagtac tctagatgat gaatgtgttt 4320 gctttgtgtt tggtattaaa catgtaagat tagaagttct caaaaaaaaa aaaaaaaaaa 4380 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa 4417 <210> 631 <211> 4417 <212> DNA <213> Homo sapiens <400> 631 ggcacgagtg gcggaaaggc tgcggccccg cgccagaggg ccggtggctc ctccgggctt 60 ctgaggaccc gcagggagcg ggcctcatca tttctgtctc ctgtttctcc acttccttct 120 ctattggttg gtccactgat gtatggactt gcacatgatg aactgtgaac ttctagccac 180 atgtagtgcc cttgggtact tggagggaga cacttaccat aaggaaccag attgcttaga 240 gagcgtgaag gatctgatcc gctatttgag gcatgaggat gagacacgag atgtgcggca 300 gcagctgggg gcagcccaga tcctacagag cgaccttctg cccatcctca cccagcacca 360 ccaggacaag cctctctttg atgctgttat cagactgatg gtgaacttga cacaaccagc 420 cttgctctgt tttggcaatc tgcctaagga gcccagcttt cggcaccatt ttttgcaggt 480 gctaacttat ttgcaggcct acaaagaggc ctttgccagt gagaaggctt ttggagtcct 540 cagtgaaacc ttgtatgagc tgctgcagct gggctgggag gaacggcagg aggaagacaa 600 cttgctgatt gaacggatcc tactgctggt cagaaatatt ctccatgtcc cagctgacct 660 tgatcaggag aagaagattg atgatgacgc cagtgcccat gaccagctcc tctgggcgat 720 tcacctcagc ggcctggatg acctgctcct ctttctggcc agctcgtctg ctgaggagca 780 atggagccta catgtgctag agattgtctc ccttatgttt cgtgaccaga accccgagca 840 gctggcggga gtagggcagg gacgcttagc tcaggagcgg agtgcagatt ttgcagaact 900 ggaggtattg cgccagcgag agatggcaga aaagaagact cgagccctcc agcgaggcaa 960 caggcattct cgatttgggg gctcctatat tgtccagggg ttgaaatcca ttggggagag 1020 ggacctcatc tttcacaaag gccttcacaa cctacgaaac tacagttcag atttgggaaa 1080 gcagccgaaa aaggtgccta aacgtcgcca ggccgcccga gagctgtcca ttcagcgccg 1140 ttctgccctc aatgtgaggc tcttcctcag agacttctgc tctgagttcc tggagaactg 1200 ttacaaccgg ctcatgggat cagtaaagga tcacctgctt cgggagaaag ctcagcagca 1260 tgatgagacc tattatatgt gggccttggc tttcttcatg gccttcaacc gagctgcctc 1320 cttccggcca ggcctggttt ctgagaccct cagtgtccgt accttccact tcattgagca 1380 gaacctcacc aactactatg agatgatgct gactgaccgc aaggaagctg cctcctgggc 1440 acgccggatg cacttggctc tgaaggccta tcaggagctg ctggcaacag tgaatgagat 1500 ggacttatct ccagatgagg ctgtgaggga gagcagccgc atcatcaaga acaatatttt 1560 ctatgtgatg gagtaccgag aactattcct ggcacttttt cgaaagtttg atgagagatg 1620 ccagccccgc tctttccttc gtgacctggt ggagaccacc cacctcttcc tcaaaatgtt 1680 ggagcgattc tgtcggagcc gtgggaacct ggtggtgcag aacaaacaaa agaagagaag 1740 gaagaagaag aagaaggtcc tagaccaggc cattgtttct ggtaatgtcc catctagccc 1800 agaagaagtg gaggctgtgt ggccagccct ggctgagcag ctacagtgct gtgcccagaa 1860 ttctgagctc agcatggact ccgtggttcc ctttgatgcg gcctcagagg tgccagtgga 1920 ggagcagcgg gcagaagcta tggtacggat ccaagactgt ctcctggctg gccaggcccc 1980 acaggccctg actctcctga ggtctgctcg ggaggtgtgg cctgaaggag atgtgtttgg 2040 ctctcaagac atttctccag aggaagagat ccagttgctg aaacaaatcc tctctgctcc 2100 acttccccgg cagcagggcc cagaggaacg tggggcagag gaagaagaag aggaggagga 2160 ggaggaagag gaggagttgc aagtggtcca ggtgtcggag aaagaattta attttctgga 2220 ctacctgaaa cgctttgcat gttcaactgt cgttcgagcc tatgtgctgc tactaaggag 2280 ctaccagcag aatagtgccc acactaacca ttgcattgtg aagatgctgc accggctggc 2340 ccatgacctc aaaatggaag ccctactttt tcagctgtca gtcttctgcc tcttcaatcg 2400 tctgcttagt gaccctgctg ctggagccta caaagagcta gtgacttttg ccaaatacat 2460 cctgggcaaa ttttttgcac tggctgcagt caaccaaaaa gcctttgtgg agctgttgtt 2520 ctggaagaac acagctgtgg ttcgagagat gactgagggc tatggctccc tggatgacag 2580 gtcttccagt cgcagagcac ctacatggag ccccgaagaa gaggctcatc ttcaggagct 2640 gtacctcgcc aataaggacg tggaagggca ggatgtggtg gaagccatct tggcccacct 2700 gaatactgtt cctcgaacac gcaagcagat catccaccat ctggtacaga tgggactggc 2760 tgacagtgtc aaggacttcc aaaggaaagg aacccatatt gtactgtgga cgggggatca 2820 ggagttggag ctgcagcggc tttttgagga attccgggac tcagatgatg tcctgggtca 2880 tatcatgaag aatatcacag ccaaacgctc acgggcccga atagtggata aactcttggc 2940 tctggggctg gtggctgagc ggcgggagct gtacaagaaa cggcagaaaa agttggcatc 3000 ctccatcttg ccaaatggag cggagtccct gaaagatttt tgccaggaag atctggaaga 3060 agaggaaaac ctgcctgagg aagacagcga agaggaagaa gaagggggct cagaagcaga 3120 acaagtccag ggtagcttag tcctttcaaa tgaaaacctt ggtcaaagcc tgcatcagga 3180 aggcttttct atcccgctcc tatggctcca gaactgcctg atccgagcag ctgatgatcg 3240 ggaagaggat ggctgctccc aggccgttcc attggtgcca ctcacagagg aaaatgagga 3300 agccatggaa aacgaacagt ttcagcagct gttgcgcaag ctaggggttc ggccccctgc 3360 ctctgggcag gaaaccttct ggcgaattcc agccaagctg agtcctaccc agctccggag 3420 ggcagcagct tctttgagtc aaccagagga ggaacagaag ctgcagccag agctgcagcc 3480 taaagtccct ggagagcaag gctctgatga ggagcactgt aaagagcacc gagcacaagc 3540 cctgagggcc ctcttgctag cccacaagaa gaaagcgggc ctggcatccc cagaggagga 3600 agacgctgtt ggtaaagagc cgctgaaggc agcacccaag aaacgacaat tgctggacag 3660 cgacgaggaa caggaagaag atgagggcag gaacagagca ccagagttgg gagctccagg 3720 aatccaaaag aagaaacgat accagattga ggatgatgag gatgactgaa gagctaagaa 3780 gcctaggggt agagatagac acgtttttag atggtgcatt caagtcagag ttggaagggt 3840 catacaggac ccagaagctc ctcttactgg acagagcagt agaatcccag gctctttcac 3900 ggatttaggc tgagaaactt cagcagcagt attggacttc tctgctgtca gtctttgttt 3960 ctcccagttt ttatcggtat gccccagcag ctctctggag atttagttct cttcttctag 4020 gaaccatttc ttttggttat tggagctcct tagcaaataa gaggagtgag tgaaatagag 4080 aaagcacccc ggaccccttt tattggtctg ttcctttggc tttctcttgg aggtgggtcg 4140 cagcaccaga tggggagctt tatgacatga caggcgggag ttttgtacca cttttagaag 4200 ataccagatg cctctgtcct cattttgttt cctatgatca tcctctagat accagataga 4260 ggcccattcc tgcatttgag atagggttgg aatatagtac tctagatgat gaatgtgttt 4320 gctttgtgtt tggtattaaa catgtaagat tagaagttct caaaaaaaaa aaaaaaaaaa 4380 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa 4417 <210> 632 <211> 1753 <212> DNA <213> Homo sapiens <400> 632 gaccggtcca gctgagcctg gtggcggaaa ggctgcggcc ccgcgccaga gggccggtgg 60 ctcctccggg cttctgagga cccgcaggga gcgggcctca tcatttctgt ctcctgtttc 120 tccacttcct tctctattgg ttggtccact gatgtatgga cttgcacatg atgaactgtg 180 aacttctagc cacatgtagt gcccttgggt acttggaggg agacacttac cataaggaac 240 cagattgctt agagagcgtg aaggatctga tccgctattt gaggcatgag gatgagacac 300 gagatgtgcg gcagcagctg ggggcagccc agatcctaca gagcgacctt ctgcccatcc 360 tcacccagca ccaccaggac aagcctctct ttgatgctgt tatcagactg atggtgaact 420 tgacacaacc agccttgctc tgttttggca atctgcctaa ggagcccagc tttcggcacc 480 attttttgca ggtgctaact tatttgcagg cctacaaaga ggcctttgcc agtgagaagg 540 cttttggagt cctcagtgaa accttgtatg agctgctgca gctgggctgg gaggaacggc 600 aggaggaaga caacttgctg attgaacgga tcctactgct ggtcagaaat attctccatg 660 ttccagctga ccttgatcag gagaagattg atgatgacgc cagtgcccat gaccagctcc 720 tctgggcgat tcacctcagc ggcctggatg acctgctcct ctttctggcc agctcgtctg 780 ctgaggagca atggagccta catgtgctag agattgtctc ccttatgttt cgtgaccaga 840 accccgagca gctggcggga gtagggcagg gacgcttagc tcaggagcgg agtgcagatt 900 ttgcagaact ggaggtattg cgccagcgag agatggcaga aaagaagact cgagccctcc 960 agcgaggcaa caggcattct cgatttgggg gctcctatat tgtccagggg ttgaaatcca 1020 ttggggagag ggacctcatc tttcacaaag gccttcacaa cctacgaaac tacagttcag 1080 atttgggaaa gcagccgaaa aaggtgccta aacgtcgcca ggccgcccga gagctgtcca 1140 ttcagcgccg ttctgccctc aatgtgaggc tcttcctcag agacttctgc tctgagttcc 1200 tggagaactg ttacaaccgg ctcatgggat cagtaaagga tcacctgctt cgggagaaag 1260 ctcagcagca tgatgagacc tattatatgt gggccttggc tttcttcatg gccttcaacc 1320 gagctgcctc cttccggcca ggcctggttt ctgagaccct cagtgtccgt accttccact 1380 tcattgagca gaacctcacc aactactatg agatgatgct gactgaccgc aaggaagctg 1440 cctcctgggc acgccggatg cacttggctc tgaaggccta tcaggagctg ctggcaacag 1500 tgaatgagat ggacttatct ccagatgagg ctgtgaggga gagcagccgc atcatcaaga 1560 acaatatttt ctatgtgatg gagtaccgag aactattcct ggcacttttt cgaaagtttg 1620 atgagagatg ccagccccgc tctttccttc gtgacctggt ggagaccacc cacctcttcc 1680 tcaaaatgtt ggagcgattc tgtcggagcc gtgggaacct ggtggtgcag aacaaacaaa 1740 aaaaaaaaaa aaa 1753 <210> 633 <211> 2087 <212> DNA <213> Homo sapiens <400> 633 aaggagctac cagcagaata gtgcccacac taaccattgc attgtgaaga tgctgcaccg 60 gctggcccat gacctcaaaa tggaagccct actttttcag ctgtcagtct tctgcctctt 120 caatcgtctg cttagtgacc ctgctgctgg agcctacaaa gagctagtga cttttgccaa 180 atacatcctg ggcaaatttt ttgcactggc tgcagtcaac caaaaagcct ttgtggagct 240 gttgttctgg aagaacacag ctgtggttcg agagatgact gagggctatg gctccctgga 300 tgacaggtct tccagtcgca gagcacctac atggagcccc gaagaagagg ctcatcttcg 360 ggagctgtac ctcgccaata aggacgtgga agggcaggat gtggtggaag ccatcttggc 420 ccacctgaat actgttcctc gaacacgcaa gcagatcatc caccatctgg tacagatggg 480 actggctgac agtgtcaagg acttccaaag gaaaggaacc catattgtac tgtggacggg 540 ggatcaggag ttggagctgc agcggctttt tgaggaattc cgggactcag atgatgtcct 600 gggtcatatc atgaagaata tcacagccaa acgctcacgg gcccgaatag tggataaact 660 cttggctctg gggctggtgg ctgagcggcg ggagctgtac aagaaacggc agaaaaagtt 720 ggcatcctcc atcttgccaa atggagcgga gtccctgaaa gatttttgcc aggaagatct 780 ggaagaagag gaaaacctgc ctgaggaaga cagcgaagag gaagaagaag ggggctcaga 840 agcagaacaa gtccagggta gcttagtcct ttcaaatgaa aaccttggtc aaagcctgca 900 tcaggaaggc ttttctatcc tgctcctatg gctccagaac tgcctgatcc gagcagctga 960 tgatcgggaa gaggatggct gctcccaggc cgttccattg gtgccactca cagaggaaaa 1020 tgaggaagcc atggaaaacg aacagtttca gcagctgttg cgcaagctag gggttcggcc 1080 ccctgcctct gggcaggaaa ccttctggcg aattccagcc aagctgagtc ctacccagct 1140 ccggagggca gcagcttctt tgagtcaacc agaggaggaa cagaagctgc agccagagct 1200 gcagcctaaa gtccctggag agcaaggctc tgatgaggag cactgtaaag agcaccgagc 1260 acaagccctg agggccctct tgctagccca caagaagaaa gcgggcctgg catccccaga 1320 ggaggaagac gctgttggta aagagccgct gaaggcagca cccaagaaac gacaattgct 1380 ggacagcgac gaggaacagg aagaagatga gggcaggaac agagcaccag agttgggagc 1440 tccaggaatc caaaagaaga aacgatacca gattgaggat gatgaggatg actgaagagc 1500 taagaagcct aggggtagag atagacacgt ttttagatgg tgcattcaag tcagagttgg 1560 aagggtcata caggacccag aagctcctct tactggacag agcagtagaa tcccaggctc 1620 tttcacggat ttaggctgag aaactttagc agcagtattg gacttctctg ctgtcagtct 1680 ttgtttctcc cagtttttat cggtatgccc cagcagctct ctggagattt agttctcttc 1740 ttctaggaac catttctttt ggttattgga gctccttagc aaataagagg agtgagtgaa 1800 atagagaaag caccccggac cccttttatt ggtctgttcc tttggctttc tcttggaggt 1860 gggtcgcagc accagatggg gagctttatg acatgacagg cgggagtttt gtaccacttt 1920 tagaagatac cagatgcctc tgtcctcatt ttgtttccta tgatcatcct ctagatacca 1980 gatagaggcc cattcctgca tttgagatag ggttggaata tagtactcta gatgatgaat 2040 gtgtttgctt tgtgtttggt attaaacatg taagattaga agttctc 2087 <210> 634 <211> 2803 <212> DNA <213> Homo sapiens <400> 634 aggccctgac tctcctgagg tctgctcggg aggtgtggcc tgaaggagat gtgtttggct 60 ctcaagacat ttctccagag gaagagatcc agttgctgaa acaaatcctc tctgctccac 120 ttccccggca gcagggccca gaggaacgtg gggcagagga agaagaagag gaggaggagg 180 aggaagagga ggagttgcaa gtggtccagc tttgcatgtt caactgtcgt tcgagcctat 240 gtgctgctac taaggagcta ccagcagaat agtgcccaca ctaaccattg cattgtgaag 300 atgctgcacc ggctggccca tgacctcaaa atggaagccc tactttttca gctgtcagtc 360 ttctgcctct tcaatcgtct gcttagtgac cctgctgctg gagcctacaa agagctagtg 420 acttttgcca aatacatcct gggcaaattt tttgcactgg ctgcagtcaa ccaaaaagcc 480 tttgtggagc tgttgttctg gaagaacaca gctgtggttc gagagatgac tgagggctat 540 ggctccctgg atgacaggtc ttccagtcgc agagcaccta catggagccc cgaagaagag 600 gctcatcttc gggagctgta cctcgccaat aaggacgtgg aagggcagga tgtggtggaa 660 gccatcttgg cccacctgaa tactgttcct cgaacacgca agcagatcat ccaccatctg 720 gtacagatgg gactggctga cagtgtcaag gacttccaaa ggaaaggaac ccatattgta 780 ctgtggacgg gggatcagga gttggagctg cagcggcttt ttgaggaatt ccgggactca 840 gatggtgagt aagctggaaa ctcaggggac ctttgagatg aaagccaagc tatccattta 900 ttttggggct gccttttatt cccaaggaaa gattctccca tcccttctgt tcacttacta 960 tatttgtaag tgtcattttt ggatgaattg aggtaccctc tttccagaga cctctgattt 1020 attttactca tctctttccc tgttaccctt gggtattcac atgcttgctt tttatagatg 1080 tcctgggtca tatcatgaag aatatcacag ccaaacgctc acgggcccga atagtggata 1140 aactcttggc tctggggctg gtggctgagc ggcgggagct gtacaagaaa cggcagaaaa 1200 agttggcatc ctccatcttg gtaacaatct gaccctagct ctgctggcat gggctcactt 1260 cccttgaagt ggtccttagg agcagtccac ctggattctt cctgcctgag gctgttctga 1320 ccaggtcctt ccgagagagc aggcgcgggg gggtgcggtg gtcagggacg aggagactcc 1380 actaagttcc ttgtgttgcc ttcattttca ttcccccaac ccccaatgaa ttttagccaa 1440 atggagcgga gtccctgaaa gatttttgcc aggaagatct ggaagaagag gaaaacctgc 1500 ctgaggaaga cagcgaagag gaagaagaag ggggctcaga agcagaacaa gtccagggta 1560 gcttagtcct ttcaaatgaa aaccttggtc aaagcctgca tcaggaaggc ttttctatcc 1620 tgctcctatg gctccagaac tgcctgatcc gagcagctga tgatcgggaa gaggatggct 1680 gctcccaggc cgttccattg gtgccactca cagaggaaaa tgaggaagcc atggaaaacg 1740 aacagtttca gcagctgttg cgcaagctag gggttcggcc ccctgcctct gggcaggaaa 1800 ccttctggcg aattccagcc aagctgagtc ctacccagct ccggagggca gcagcttctt 1860 tgagtcaacc agaggaggaa cagaagctgc agccagagct gcagcctaaa gtccctggag 1920 agcaaggctc tgatgaggag cactgtaaag agcaccgagc acaagccctg agggccctct 1980 tgctagccca caagaagaaa gcgggcctgg catccccaga ggaggaagac gctgttggta 2040 aagagccgct gaaggcagca cccaagaaac gacaattgct ggacagcgac gaggaacagg 2100 aagaagatga gggcaggaac agagcaccag agttgggagc tccaggaatc caaaagaaga 2160 aacgatacca gattgaggat gatgaggatg actgaagagc taagaagcct aggggtagag 2220 atagacacgt ttttagatgg tgcattcaag tcagagttgg aagggtcata caggacccag 2280 aagctcctct tactggacag agcagtagaa tcccaggctc tttcacggat ttaggctgag 2340 aaacttcagc agcagtattg gacttctctg ctgtcagtct ttgtttctcc cagtttttat 2400 cggtatgccc cagcagctct ctggagattt agttctcttc ttctaggaac catttctttt 2460 ggttattgga gctccttagc aaataagagg agtgagtgaa atagagaaag caccccggac 2520 cccttttatt ggtctgttcc tttggctttc tcttggaggt gggtcgcagc accagatggg 2580 gagctttatg acatgacagg cgggagtttt gtaccacttt tagaagatac cagatgcctc 2640 tgtcctcatt ttgtttccta tgatcatcct ctagatacca gatagaggcc cattcctgca 2700 tttgagatag ggttggaata tagtactcta gatgatgaat gtgtttgctt tgtgtttggt 2760 attaaacatg taagattaga agttaaaaaa aaaaaaaaaa aaa 2803 <210> 635 <211> 2147 <212> DNA <213> Homo sapiens <400> 635 aacggtagaa ttagttggca ttttccatct tgcttaatgg agcggagtcc ctgaaagatt 60 tttgccagga agatctggaa gaagaggaaa acctgcctga ggaagacagc gaagaggaag 120 aagaaggggg ctcagaagca gaacaagtcc agggtagctt agtcctttca aatgaaaacc 180 ttggtcaaag cctgcatcag gaaggctttt ctatcctgct cctatggctc cagaactgcc 240 tgatccgagc agctgatgat cgggaagagg atggctgctc ccaggccgtt ccattggtgc 300 cactcacaga ggaaaatgag gaagccatgg aaaacgaaca gtttcagcag ctgttgcgca 360 agctaggggt tcggccccct gcctctgggc aggaaacctt ctggcgaatt ccagccaagc 420 tgagtcctac ccagctccgg agggcagcag cttctttgag tcaaccagag gaggaacaga 480 agctgcagcc agagctgcag cctaaagtcc ctggagggca aggctctgat gaggagcact 540 gtaaagagca ccgagcacaa gccctgaggg ccctcttgct agcccacaag aagaaagcgg 600 gcctggcatc cccagaggag gaagacgctg ttggtaaaga gccgctgaag gcagcaccca 660 agaaacgaca attgctggac agcgacgagg aacaggaaga agatgagggc aggaacagag 720 caccagagtt gggagctcca ggaatccaaa agaagaaacg ataccagatt gaggatgatg 780 aggatgactg aagagctaag aagcctaggg gtagagatag acacgttttt agatggtgca 840 ttcaagtcag agttggaagg gtcatacagg acccagaagc tcctcttact ggacagagca 900 gtagaatccc aggctctttc acggatttag gctgagaaac ttcagcagca gtattggact 960 tctctgctgt cagtctttgt ttctcccagt ttttatcggt atgccccagc agctctctgg 1020 agatttagtt ctcttcttct aggaaccatt tcttttggtt attggagctc cttagcaaat 1080 aagaggagtg agtgaaatag agaaagcacc ccggacccct tttattggtc tgttcctttg 1140 gctttctctt ggaggtgggt cgcagcacca gatggggagc tttatgacat gacaggcggg 1200 agttttgtac cacttttaga agataccaga tgcctctgtc ctcattttgt ttcctatgat 1260 catcctctag ataccagata gaggcccatt cctgcatttg agatagggtt ggaatatagt 1320 actctagatg atgaatgtgt ttgctttgtg tttggtatta aacatgtaag attagaagtt 1380 ctcatctcag tctgacttgg cgatatgtct aagttcccca gcccttcccc tgctgtgctc 1440 ttgaaagaag aacttaacaa ttttagggta aaaagagacc aacagaccgg cacagtggct 1500 caaacctgtt gtcctagcac tttgggaggc tgaggcgggc ggatcacctg aggtcaggag 1560 tttgagaccg gcctggacaa tatggcgaaa tcccatctcc actaaaaata caaaaattag 1620 ccggccatgg tggcatgcgc ctgtaatccc agccactcgg gtggctgagg caggagaatt 1680 gcctgaaccc aggaggcaga ggttgcagtg agctaaggtc acgccagtgc atatgcctgg 1740 gcgacagagc aagactctgt ctcaaaaaaa aaaaaaaaaa aagaccaaca accttccctt 1800 ttcttccgct ttccctacag aagacacaga aaagcatttt tgcctctaga tccttttgtc 1860 tagggtaaat tcttagggtg acaagagtat gcggcaggaa gaaggagaag ccataaagga 1920 agagaagcca gcttgttggc atggggcata gaaaaggaca aaatctaggc atgaaaagga 1980 tggataaata ctgcaaatat tatgttctta cccattcttg gaaacgtcag ctttcttgct 2040 tcctgtgctt ccagccgagg tagggcaaag gtgagattga gaaaatagcc attcagctca 2100 ggaaggcttt taagtaaagg atggatttgg aaaaaaaaaa aaaaaaa 2147 <210> 636 <211> 647 <212> DNA <213> Homo sapiens <220> <221> misc_feature <222> (5)..(5) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (7)..(7) <223> "n" means any of A, T, G, and C. <400> 636 ggctngnagg ggggatcagg agttggagct gcagcggctt tttgaggaat tccgggactc 60 agatggtgag taagctggaa actcagggga cctttgagat gaaagccaag ctatccattt 120 attttggggc tgccttttat tcccaaggaa agattctccc atcccttcag ttcacttact 180 atatttgtaa gtgtcatttt tggatgaatt gaggtaccct ctttccagag acctctgatt 240 tattttactc atccctttcc ctgttaccct tgggtattca catgcttgct ttttatagat 300 gtcctgggtc atatcatgaa gaatatcaca gccaaacgct cacgggcccg aatagtggat 360 aaactcttgg ctctggggct ggtggctgag cggcgggagc tgtacaagaa acggcagaaa 420 aagttggcat cctccatctt ggtaacaatc tgaccctagc tctgctggca tgggctcact 480 tcccttgaag tggtccttag gagcagtcca cctggattct tcctgcctga ggctgttctg 540 accaggtcct tccgagagag caggcgcggg ggggtgcggt ggtcaggaac gaggagactc 600 cactaagttc cttgtgttgc cttcattttc attcccccct ccaagcc 647 <210> 637 <211> 365 <212> DNA <213> Homo sapiens <220> <221> misc_feature <222> (8)..(8) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (13)..(13) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (19)..(19) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (22)..(24) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (40)..(40) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (57)..(57) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (77)..(77) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (158)..(158) <223> "n" means any of A, T, G, and C. <220> <221> misc_feature <222> (162)..(162) <223> "n" means any of A, T, G, and C. <400> 637 ggggcccngg gangggttng gnnnggaaat tttttccagn aagccccggg ccttttnaaa 60 aagccagcct gggaatntcc ccaaggggta accggggaaa ggggatgagg taaaataaaa 120 ttcagaggtt cttctggaaa gagggtacct ccaaattnca tnccaaaaat gacacttaca 180 aatatagtaa gtgaactgaa gggatgggag aatctttcct tgggaataaa aggcagcccc 240 aaaataaatg gatagcttgg ctttcatctc aaaggtcccc tgagtttcca gcttactcac 300 catctgagtc ccggaattcc tcaaaaagcc gctgcagctc caactcctga tcccccctcc 360 aagcc 365 <210> 638 <211> 875 <212> PRT <213> Homo sapiens <400> 638 Met Asp Glu Glu Glu Asp Asn Leu Ser Leu Leu Thr Ala Leu Leu Glu 1 5 10 15 Glu Asn Glu Ser Ala Leu Asp Cys Asn Ser Glu Glu Asn Asn Phe Leu 20 25 30 Thr Arg Glu Asn Gly Glu Pro Asp Ala Phe Asp Glu Leu Phe Asp Ala 35 40 45 Asp Gly Asp Gly Glu Ser Tyr Thr Glu Glu Ala Asp Asp Gly Glu Thr 50 55 60 Gly Glu Thr Arg Asp Glu Lys Glu Asn Leu Ala Thr Leu Phe Gly Asp 65 70 75 80 Met Glu Asp Leu Thr Asp Glu Glu Glu Val Pro Ala Ser Gln Ser Thr 85 90 95 Glu Asn Arg Val Leu Pro Ala Pro Ala Pro Arg Arg Glu Lys Thr Asn 100 105 110 Glu Glu Leu Gln Glu Glu Leu Arg Asn Leu Gln Glu Gln Met Lys Ala 115 120 125 Leu Gln Glu Gln Leu Lys Val Thr Thr Ile Lys Gln Thr Ala Ser Pro 130 135 140 Ala Arg Leu Gln Lys Ser Pro Val Glu Lys Ser Pro Arg Pro Pro Leu 145 150 155 160 Lys Glu Arg Arg Val Gln Arg Ile Gln Glu Ser Thr Cys Phe Ser Ala 165 170 175 Glu Leu Asp Val Pro Ala Leu Pro Arg Thr Lys Arg Val Ala Arg Thr 180 185 190 Pro Lys Ala Ser Pro Pro Asp Pro Lys Ser Ser Ser Ser Arg Met Thr 195 200 205 Ser Ala Pro Ser Gln Pro Leu Gln Thr Ile Ser Arg Asn Lys Pro Ser 210 215 220 Gly Ile Thr Arg Gly Gln Ile Val Gly Thr Pro Gly Ser Ser Gly Glu 225 230 235 240 Thr Thr Gln Pro Ile Cys Val Glu Ala Phe Ser Gly Leu Arg Leu Arg 245 250 255 Arg Pro Arg Val Ser Ser Thr Glu Met Asn Lys Lys Met Thr Gly Arg 260 265 270 Lys Leu Ile Arg Leu Ser Gln Ile Lys Glu Lys Met Ala Arg Glu Lys 275 280 285 Leu Glu Glu Ile Asp Trp Val Thr Phe Gly Val Ile Leu Lys Lys Val 290 295 300 Thr Pro Gln Ser Val Asn Ser Gly Lys Thr Phe Ser Ile Trp Lys Leu 305 310 315 320 Asn Asp Leu Arg Asp Leu Thr Gln Cys Val Ser Leu Phe Leu Phe Gly 325 330 335 Glu Val His Lys Ala Leu Trp Lys Thr Glu Gln Gly Thr Val Val Gly 340 345 350 Ile Leu Asn Ala Asn Pro Met Lys Pro Lys Asp Gly Ser Glu Glu Val 355 360 365 Cys Leu Ser Ile Asp His Pro Gln Lys Val Leu Ile Met Gly Glu Ala 370 375 380 Leu Asp Leu Gly Thr Cys Lys Ala Lys Lys Lys Asn Gly Glu Pro Cys 385 390 395 400 Thr Gln Thr Val Asn Leu Arg Asp Cys Glu Tyr Cys Gln Tyr His Val 405 410 415 Gln Ala Gln Tyr Lys Lys Leu Ser Ala Lys Arg Ala Asp Leu Gln Ser 420 425 430 Thr Phe Ser Gly Gly Arg Ile Pro Lys Lys Phe Ala Arg Arg Gly Thr 435 440 445 Ser Leu Lys Glu Arg Leu Cys Gln Asp Gly Phe Tyr Tyr Gly Gly Val 450 455 460 Ser Ser Ala Ser Tyr Ala Ala Ser Ile Ala Ala Ala Val Ala Pro Lys 465 470 475 480 Lys Lys Ile Gln Thr Thr Leu Ser Asn Leu Val Val Lys Gly Thr Asn 485 490 495 Leu Ile Ile Gln Glu Thr Arg Gln Lys Leu Gly Ile Pro Gln Lys Ser 500 505 510 Leu Ser Cys Ser Glu Glu Phe Lys Glu Leu Met Asp Leu Pro Thr Cys 515 520 525 Gly Ala Arg Asn Leu Lys Gln His Leu Ala Lys Ala Thr Ala Ser Gly 530 535 540 Ile Met Gly Ser Pro Lys Pro Ala Ile Lys Ser Ile Ser Ala Ser Ala 545 550 555 560 Leu Leu Lys Gln Gln Lys Gln Arg Met Leu Glu Met Arg Arg Arg Lys 565 570 575 Ser Glu Glu Ile Gln Lys Arg Phe Leu Gln Ser Ser Ser Glu Val Glu 580 585 590 Ser Pro Ala Val Pro Ser Ser Ser Arg Gln Pro Pro Ala Gln Pro Pro 595 600 605 Arg Thr Gly Ser Glu Phe Pro Arg Leu Glu Gly Ala Pro Ala Thr Met 610 615 620 Thr Pro Lys Leu Gly Arg Gly Val Leu Glu Gly Asp Asp Val Leu Phe 625 630 635 640 Tyr Asp Glu Ser Pro Pro Pro Arg Pro Lys Leu Ser Ala Leu Ala Glu 645 650 655 Ala Lys Lys Leu Ala Ala Ile Thr Lys Leu Arg Ala Lys Gly Gln Val 660 665 670 Leu Thr Lys Thr Asn Pro Asn Ser Ile Lys Lys Lys Gln Lys Asp Pro 675 680 685 Gln Asp Ile Leu Glu Val Lys Glu Arg Val Glu Lys Asn Thr Met Phe 690 695 700 Ser Ser Gln Ala Glu Asp Glu Leu Glu Pro Ala Arg Lys Lys Arg Arg 705 710 715 720 Glu Gln Leu Ala Tyr Leu Glu Ser Glu Glu Phe Gln Lys Ile Leu Lys 725 730 735 Ala Lys Ser Lys His Thr Gly Ile Leu Lys Glu Ala Glu Ala Glu Met 740 745 750 Gln Glu Arg Tyr Phe Glu Pro Leu Val Lys Lys Glu Gln Met Glu Glu 755 760 765 Lys Met Arg Asn Ile Arg Glu Val Lys Cys Arg Val Val Thr Cys Lys 770 775 780 Thr Cys Ala Tyr Thr His Phe Lys Leu Leu Glu Thr Cys Val Ser Glu 785 790 795 800 Gln His Glu Tyr His Trp His Asp Gly Val Lys Arg Phe Phe Lys Cys 805 810 815 Pro Cys Gly Asn Arg Ser Ile Ser Leu Asp Arg Leu Pro Asn Lys His 820 825 830 Cys Ser Asn Cys Gly Leu Tyr Lys Trp Glu Arg Asp Gly Met Leu Lys 835 840 845 Glu Lys Thr Gly Pro Lys Ile Gly Gly Glu Thr Leu Leu Pro Arg Gly 850 855 860 Glu Glu His Ala Lys Phe Leu Asn Ser Leu Lys 865 870 875 <210> 639 <211> 861 <212> PRT <213> Homo sapiens <400> 639 Met Ala His Tyr Pro Thr Arg Leu Lys Thr Arg Lys Thr Tyr Ser Trp 1 5 10 15 Val Gly Arg Pro Leu Leu Asp Arg Lys Leu His Tyr Gln Thr Tyr Arg 20 25 30 Glu Met Cys Val Lys Thr Glu Gly Cys Ser Thr Glu Ile His Ile Gln 35 40 45 Ile Gly Gln Phe Val Leu Ile Glu Gly Asp Asp Asp Glu Asn Pro Tyr 50 55 60 Val Ala Lys Leu Leu Glu Leu Phe Glu Asp Asp Ser Asp Pro Pro Pro 65 70 75 80 Lys Lys Arg Ala Arg Val Gln Trp Phe Val Arg Phe Cys Glu Val Pro 85 90 95 Ala Cys Lys Arg His Leu Leu Gly Arg Lys Pro Gly Ala Gln Glu Ile 100 105 110 Phe Trp Tyr Asp Tyr Pro Ala Cys Asp Ser Asn Ile Asn Ala Glu Thr 115 120 125 Ile Ile Gly Leu Val Arg Val Ile Pro Leu Ala Pro Lys Asp Val Val 130 135 140 Pro Thr Asn Leu Lys Asn Glu Lys Thr Leu Phe Val Lys Leu Ser Trp 145 150 155 160 Asn Glu Lys Lys Phe Arg Pro Leu Ser Ser Glu Leu Phe Ala Glu Leu 165 170 175 Asn Lys Pro Gln Glu Ser Ala Ala Lys Cys Gln Lys Pro Val Arg Ala 180 185 190 Lys Ser Lys Ser Ala Glu Ser Pro Ser Trp Thr Pro Ala Glu His Val 195 200 205 Ala Lys Arg Ile Glu Ser Arg His Ser Ala Ser Lys Ser Arg Gln Thr 210 215 220 Pro Thr His Pro Leu Thr Pro Arg Ala Arg Lys Arg Leu Glu Leu Gly 225 230 235 240 Asn Leu Gly Asn Pro Gln Met Ser Gln Gln Thr Ser Cys Ala Ser Leu 245 250 255 Asp Ser Pro Gly Arg Ile Lys Arg Lys Val Ala Phe Ser Glu Ile Thr 260 265 270 Ser Pro Ser Lys Arg Ser Gln Pro Asp Lys Leu Gln Thr Leu Ser Pro 275 280 285 Ala Leu Lys Ala Pro Glu Lys Thr Arg Glu Thr Gly Leu Ser Tyr Thr 290 295 300 Glu Asp Asp Lys Lys Ala Ser Pro Glu His Arg Ile Ile Leu Arg Thr 305 310 315 320 Arg Ile Ala Ala Ser Lys Thr Ile Asp Ile Arg Glu Glu Arg Thr Leu 325 330 335 Thr Pro Ile Ser Gly Gly Gln Arg Ser Ser Val Val Pro Ser Val Ile 340 345 350 Leu Lys Pro Glu Asn Ile Lys Lys Arg Asp Ala Lys Glu Ala Lys Ala 355 360 365 Gln Asn Glu Ala Thr Ser Thr Pro His Arg Ile Arg Arg Lys Ser Ser 370 375 380 Val Leu Thr Met Asn Arg Ile Arg Gln Gln Leu Arg Phe Leu Gly Asn 385 390 395 400 Ser Lys Ser Asp Gln Glu Glu Lys Glu Ile Leu Pro Ala Ala Glu Ile 405 410 415 Ser Asp Ser Ser Ser Asp Glu Glu Glu Ala Ser Thr Pro Pro Leu Pro 420 425 430 Arg Arg Ala Pro Arg Thr Val Ser Arg Asn Leu Arg Ser Ser Leu Lys 435 440 445 Ser Ser Leu His Thr Leu Thr Lys Val Pro Lys Lys Ser Leu Lys Pro 450 455 460 Arg Thr Pro Arg Cys Ala Ala Pro Gln Ile Arg Ser Arg Ser Leu Ala 465 470 475 480 Ala Gln Glu Pro Ala Ser Val Leu Glu Glu Ala Arg Leu Arg Leu His 485 490 495 Val Ser Ala Val Pro Glu Ser Leu Pro Cys Arg Glu Gln Glu Phe Gln 500 505 510 Asp Ile Tyr Asn Phe Val Glu Ser Lys Leu Leu Asp His Thr Gly Gly 515 520 525 Cys Met Tyr Ile Ser Gly Val Pro Gly Thr Gly Lys Thr Ala Thr Val 530 535 540 His Glu Val Ile Arg Cys Leu Gln Gln Ala Ala Gln Ala Asn Asp Val 545 550 555 560 Pro Pro Phe Gln Tyr Ile Glu Val Asn Gly Met Lys Leu Thr Glu Pro 565 570 575 His Gln Val Tyr Val Gln Ile Leu Gln Lys Leu Thr Gly Gln Lys Ala 580 585 590 Thr Ala Asn His Ala Ala Glu Leu Leu Ala Lys Gln Phe Cys Thr Arg 595 600 605 Gly Ser Pro Gln Glu Thr Thr Val Leu Leu Val Asp Glu Leu Asp Leu 610 615 620 Leu Trp Thr His Lys Gln Asp Ile Met Tyr Asn Leu Phe Asp Trp Pro 625 630 635 640 Thr His Lys Glu Ala Arg Leu Val Val Leu Ala Ile Ala Asn Thr Met 645 650 655 Asp Leu Pro Glu Arg Ile Met Met Asn Arg Val Ser Ser Arg Leu Gly 660 665 670 Leu Thr Arg Met Cys Phe Gln Pro Tyr Thr Tyr Ser Gln Leu Gln Gln 675 680 685 Ile Leu Arg Ser Arg Leu Lys His Leu Lys Ala Phe Glu Asp Asp Ala 690 695 700 Ile Gln Leu Val Ala Arg Lys Val Ala Ala Leu Ser Gly Asp Ala Arg 705 710 715 720 Arg Cys Leu Asp Ile Cys Arg Arg Ala Thr Glu Ile Cys Glu Phe Ser 725 730 735 Gln Gln Lys Pro Asp Ser Pro Gly Leu Val Thr Ile Ala His Ser Met 740 745 750 Glu Ala Val Asp Glu Met Phe Ser Ser Ser Tyr Ile Thr Ala Ile Lys 755 760 765 Asn Ser Ser Val Leu Glu Gln Ser Phe Leu Arg Ala Ile Leu Ala Glu 770 775 780 Phe Arg Arg Ser Gly Leu Glu Glu Ala Thr Phe Gln Gln Ile Tyr Ser 785 790 795 800 Gln His Val Ala Leu Cys Arg Met Glu Gly Leu Pro Tyr Pro Thr Met 805 810 815 Ser Glu Thr Met Ala Val Cys Ser His Leu Gly Ser Cys Arg Leu Leu 820 825 830 Leu Val Glu Pro Ser Arg Asn Asp Leu Leu Leu Arg Val Arg Leu Asn 835 840 845 Val Ser Gln Asp Asp Val Leu Tyr Ala Leu Lys Asp Glu 850 855 860 <210> 640 <211> 712 <212> PRT <213> Homo sapiens <400> 640 Met Ala Thr Ser Ser Met Ser Lys Gly Cys Phe Val Phe Lys Pro Asn 1 5 10 15 Ser Lys Lys Arg Lys Ile Ser Leu Pro Ile Glu Asp Tyr Phe Asn Lys 20 25 30 Gly Lys Asn Glu Pro Glu Asp Ser Lys Leu Arg Phe Glu Thr Tyr Gln 35 40 45 Leu Ile Trp Gln Gln Met Lys Ser Glu Asn Glu Arg Leu Gln Glu Glu 50 55 60 Leu Asn Lys Asn Leu Phe Asp Asn Leu Ile Glu Phe Leu Gln Lys Ser 65 70 75 80 His Ser Gly Phe Gln Lys Asn Ser Arg Asp Leu Gly Gly Gln Ile Lys 85 90 95 Leu Arg Glu Ile Pro Thr Ala Ala Leu Val Leu Gly Val Asn Val Thr 100 105 110 Asp His Asp Leu Thr Phe Gly Ser Leu Thr Glu Ala Leu Gln Asn Asn 115 120 125 Val Thr Pro Tyr Val Val Ser Leu Gln Ala Lys Asp Cys Pro Asp Met 130 135 140 Lys His Phe Leu Gln Lys Leu Ile Ser Gln Leu Met Asp Cys Cys Val 145 150 155 160 Asp Ile Lys Ser Lys Glu Glu Glu Ser Val His Val Thr Gln Arg Lys 165 170 175 Thr His Tyr Ser Met Asp Ser Leu Ser Ser Trp Tyr Met Thr Val Thr 180 185 190 Gln Lys Thr Asp Pro Lys Met Leu Ser Lys Lys Arg Thr Thr Ser Ser 195 200 205 Gln Trp Gln Ser Pro Pro Val Val Val Ile Leu Lys Asp Met Glu Ser 210 215 220 Phe Ala Thr Lys Val Leu Gln Asp Phe Ile Ile Ile Ser Ser Gln His 225 230 235 240 Leu His Glu Phe Pro Leu Ile Leu Ile Phe Gly Ile Ala Thr Ser Pro 245 250 255 Ile Ile Ile His Arg Leu Leu Pro His Ala Val Ser Ser Leu Leu Cys 260 265 270 Ile Glu Leu Phe Gln Ser Leu Ser Cys Lys Glu His Leu Thr Thr Val 275 280 285 Leu Asp Lys Leu Leu Leu Thr Thr Gln Phe Pro Phe Lys Ile Asn Glu 290 295 300 Lys Val Leu Gln Val Leu Thr Asn Ile Phe Leu Tyr His Asp Phe Ser 305 310 315 320 Val Gln Asn Phe Ile Lys Gly Leu Gln Leu Ser Leu Leu Glu His Phe 325 330 335 Tyr Ser Gln Pro Leu Ser Val Leu Cys Cys Asn Leu Pro Glu Ala Lys 340 345 350 Arg Arg Ile Asn Phe Leu Ser Asn Asn Gln Cys Glu Asn Ile Arg Arg 355 360 365 Leu Pro Ser Phe Arg Arg Tyr Val Glu Lys Gln Ala Ser Glu Lys Gln 370 375 380 Val Ala Leu Leu Thr Asn Glu Arg Tyr Leu Lys Glu Glu Thr Gln Leu 385 390 395 400 Leu Leu Glu Asn Leu His Val Tyr His Met Asn Tyr Phe Leu Val Leu 405 410 415 Arg Cys Leu His Lys Phe Thr Ser Ser Leu Pro Lys Tyr Pro Leu Gly 420 425 430 Arg Gln Ile Arg Glu Leu Tyr Cys Thr Cys Leu Glu Lys Asn Ile Trp 435 440 445 Asp Ser Glu Glu Tyr Ala Ser Val Leu Gln Leu Leu Arg Met Leu Ala 450 455 460 Lys Asp Glu Leu Met Thr Ile Leu Glu Lys Cys Phe Lys Val Phe Lys 465 470 475 480 Ser Tyr Cys Glu Asn His Leu Gly Ser Thr Ala Lys Arg Ile Glu Glu 485 490 495 Phe Leu Ala Gln Phe Gln Ser Leu Asp Ala Glu Thr Lys Glu Glu Glu 500 505 510 Asp Ala Ser Gly Ser Gln Pro Lys Gly Leu Gln Lys Thr Asp Leu Tyr 515 520 525 His Leu Gln Lys Ser Leu Leu Glu Met Lys Glu Leu Arg Arg Ser Lys 530 535 540 Lys Gln Thr Lys Phe Glu Val Leu Arg Glu Asn Val Val Asn Phe Ile 545 550 555 560 Asp Cys Leu Val Arg Glu Tyr Leu Leu Pro Pro Glu Thr Gln Pro Leu 565 570 575 His Glu Val Val Tyr Phe Ser Ala Ala His Ala Leu Arg Glu His Leu 580 585 590 Asn Ala Ala Pro Arg Ile Ala Leu His Thr Ala Leu Asn Asn Pro Tyr 595 600 605 Tyr Tyr Leu Lys Asn Glu Ala Leu Lys Ser Glu Glu Gly Cys Ile Pro 610 615 620 Asn Ile Ala Pro Asp Ile Cys Ile Ala Tyr Lys Leu His Leu Glu Cys 625 630 635 640 Ser Arg Leu Ile Asn Leu Val Asp Trp Ser Glu Ala Phe Ala Thr Val 645 650 655 Val Thr Ala Ala Glu Lys Met Asp Ala Asn Ser Ala Thr Ser Glu Glu 660 665 670 Met Asn Glu Ile Ile His Ala Arg Phe Ile Arg Ala Val Ser Glu Leu 675 680 685 Glu Leu Leu Gly Phe Ile Lys Pro Thr Lys Gln Lys Thr Asp His Val 690 695 700 Ala Arg Leu Thr Trp Gly Gly Cys 705 710 <210> 641 <211> 560 <212> PRT <213> Homo sapiens <400> 641 Met Pro Gln Thr Arg Ser Gln Ala Gln Ala Thr Ile Ser Phe Pro Lys 1 5 10 15 Arg Lys Leu Ser Arg Ala Leu Asn Lys Ala Lys Asn Ser Ser Asp Ala 20 25 30 Lys Leu Glu Pro Thr Asn Val Gln Thr Val Thr Cys Ser Pro Arg Val 35 40 45 Lys Ala Leu Pro Leu Ser Pro Arg Lys Arg Leu Gly Asp Asp Asn Leu 50 55 60 Cys Asn Thr Pro His Leu Pro Pro Cys Ser Pro Pro Lys Gln Gly Lys 65 70 75 80 Lys Glu Asn Gly Pro Pro His Ser His Thr Leu Lys Gly Arg Arg Leu 85 90 95 Val Phe Asp Asn Gln Leu Thr Ile Lys Ser Pro Ser Lys Arg Glu Leu 100 105 110 Ala Lys Val His Gln Asn Lys Ile Leu Ser Ser Val Arg Lys Ser Gln 115 120 125 Glu Ile Thr Thr Asn Ser Glu Gln Arg Cys Pro Leu Lys Lys Glu Ser 130 135 140 Ala Cys Val Arg Leu Phe Lys Gln Glu Gly Thr Cys Tyr Gln Gln Ala 145 150 155 160 Lys Leu Val Leu Asn Thr Ala Val Pro Asp Arg Leu Pro Ala Arg Glu 165 170 175 Arg Glu Met Asp Val Ile Arg Asn Phe Leu Arg Glu His Ile Cys Gly 180 185 190 Lys Lys Ala Gly Ser Leu Tyr Leu Ser Gly Ala Pro Gly Thr Gly Lys 195 200 205 Thr Ala Cys Leu Ser Arg Ile Leu Gln Asp Leu Lys Lys Glu Leu Lys 210 215 220 Gly Phe Lys Thr Ile Met Leu Asn Cys Met Ser Leu Arg Thr Ala Gln 225 230 235 240 Ala Val Phe Pro Ala Ile Ala Gln Glu Ile Cys Gln Glu Glu Val Ser 245 250 255 Arg Pro Ala Gly Lys Asp Met Met Arg Lys Leu Glu Lys His Met Thr 260 265 270 Ala Glu Lys Gly Pro Met Ile Val Leu Val Leu Asp Glu Met Asp Gln 275 280 285 Leu Asp Ser Lys Gly Gln Asp Val Leu Tyr Thr Leu Phe Glu Trp Pro 290 295 300 Trp Leu Ser Asn Ser His Leu Val Leu Ile Gly Ile Ala Asn Thr Leu 305 310 315 320 Asp Leu Thr Asp Arg Ile Leu Pro Arg Leu Gln Ala Arg Glu Lys Cys 325 330 335 Lys Pro Gln Leu Leu Asn Phe Pro Pro Tyr Thr Arg Asn Gln Ile Val 340 345 350 Thr Ile Leu Gln Asp Arg Leu Asn Gln Val Ser Arg Asp Gln Val Leu 355 360 365 Asp Asn Ala Ala Val Gln Phe Cys Ala Arg Lys Val Ser Ala Val Ser 370 375 380 Gly Asp Val Arg Lys Ala Leu Asp Val Cys Arg Arg Ala Ile Glu Ile 385 390 395 400 Val Glu Ser Asp Val Lys Ser Gln Thr Ile Leu Lys Pro Leu Ser Glu 405 410 415 Cys Lys Ser Pro Ser Glu Pro Leu Ile Pro Lys Arg Val Gly Leu Ile 420 425 430 His Ile Ser Gln Val Ile Ser Glu Val Asp Gly Asn Arg Met Thr Leu 435 440 445 Ser Gln Glu Gly Ala Gln Asp Ser Phe Pro Leu Gln Gln Lys Ile Leu 450 455 460 Val Cys Ser Leu Met Leu Leu Ile Arg Gln Leu Lys Ile Lys Glu Val 465 470 475 480 Thr Leu Gly Lys Leu Tyr Glu Ala Tyr Ser Lys Val Cys Arg Lys Gln 485 490 495 Gln Val Ala Ala Val Asp Gln Ser Glu Cys Leu Ser Leu Ser Gly Leu 500 505 510 Leu Glu Ala Arg Gly Ile Leu Gly Leu Lys Arg Asn Lys Glu Thr Arg 515 520 525 Leu Thr Lys Val Phe Phe Lys Ile Glu Glu Lys Glu Ile Glu His Ala 530 535 540 Leu Lys Asp Lys Ala Leu Ile Gly Asn Ile Leu Ala Thr Gly Leu Pro 545 550 555 560 <210> 642 <211> 546 <212> PRT <213> Homo sapiens <400> 642 Met Glu Gln Arg Arg Val Thr Asp Phe Phe Ala Arg Arg Arg Pro Gly 1 5 10 15 Pro Pro Arg Ile Ala Pro Pro Lys Leu Ala Cys Arg Thr Pro Ser Pro 20 25 30 Ala Arg Pro Ala Leu Arg Ala Pro Ala Ser Ala Thr Ser Gly Ser Arg 35 40 45 Lys Arg Ala Arg Pro Pro Ala Ala Pro Gly Arg Asp Gln Ala Arg Pro 50 55 60 Pro Ala Arg Arg Arg Leu Arg Leu Ser Val Asp Glu Val Ser Ser Pro 65 70 75 80 Ser Thr Pro Glu Ala Pro Asp Ile Pro Ala Cys Pro Ser Pro Gly Gln 85 90 95 Lys Ile Lys Lys Ser Thr Pro Ala Ala Gly Gln Pro Pro His Leu Thr 100 105 110 Ser Ala Gln Asp Gln Asp Thr Ile Ser Glu Leu Ala Ser Cys Leu Gln 115 120 125 Arg Ala Arg Glu Leu Gly Ala Arg Val Arg Ala Leu Lys Ala Ser Ala 130 135 140 Gln Asp Ala Gly Glu Ser Cys Thr Pro Glu Ala Glu Gly Arg Pro Glu 145 150 155 160 Glu Pro Cys Gly Glu Lys Ala Pro Ala Tyr Gln Arg Phe His Ala Leu 165 170 175 Ala Gln Pro Gly Leu Pro Gly Leu Val Leu Pro Tyr Lys Tyr Gln Val 180 185 190 Leu Ala Glu Met Phe Arg Ser Met Asp Thr Ile Val Gly Met Leu His 195 200 205 Asn Arg Ser Glu Thr Pro Thr Phe Ala Lys Val Gln Arg Gly Val Gln 210 215 220 Asp Met Met Arg Arg Arg Phe Glu Glu Arg Asn Val Gly Gln Ile Lys 225 230 235 240 Thr Val Tyr Pro Ala Ser Tyr Arg Phe Arg Gln Glu Arg Ser Val Pro 245 250 255 Thr Phe Lys Asp Gly Ala Arg Arg Ser Asp Tyr Gln Leu Thr Ile Glu 260 265 270 Pro Leu Leu Glu Gln Glu Ala Asp Gly Ala Ala Pro Gln Leu Thr Ala 275 280 285 Ser Arg Leu Leu Gln Arg Arg Gln Ile Phe Ser Gln Lys Leu Val Glu 290 295 300 His Val Lys Glu His His Lys Ala Phe Leu Ala Ser Leu Ser Pro Ala 305 310 315 320 Met Val Val Pro Glu Asp Gln Leu Thr Arg Trp His Pro Arg Phe Asn 325 330 335 Val Asp Glu Val Pro Asp Ile Glu Pro Ala Ala Leu Pro Gln Pro Pro 340 345 350 Ala Thr Glu Lys Leu Thr Thr Ala Gln Glu Val Leu Ala Arg Ala Arg 355 360 365 Asn Leu Ile Ser Pro Arg Met Glu Lys Ala Leu Ser Gln Leu Ala Leu 370 375 380 Arg Ser Ala Ala Pro Ser Ser Pro Gly Ser Pro Arg Pro Ala Leu Pro 385 390 395 400 Ala Thr Pro Pro Ala Thr Pro Pro Ala Ala Ser Pro Ser Ala Leu Lys 405 410 415 Gly Val Ser Gln Asp Leu Leu Glu Arg Ile Arg Ala Lys Glu Ala Gln 420 425 430 Lys Gln Leu Ala Gln Met Thr Arg Cys Pro Glu Gln Glu Gln Arg Leu 435 440 445 Gln Arg Leu Glu Arg Leu Pro Glu Leu Ala Arg Val Leu Arg Ser Val 450 455 460 Phe Val Ser Glu Arg Lys Pro Ala Leu Ser Met Glu Val Ala Cys Ala 465 470 475 480 Arg Met Val Gly Ser Cys Cys Thr Ile Met Ser Pro Gly Glu Met Glu 485 490 495 Lys His Leu Leu Leu Leu Ser Glu Leu Leu Pro Asp Trp Leu Ser Leu 500 505 510 His Arg Ile Arg Thr Asp Thr Tyr Val Lys Leu Asp Lys Ala Ala Asp 515 520 525 Leu Ala His Ile Thr Ala Arg Leu Ala His Gln Thr Arg Ala Glu Glu 530 535 540 Gly Leu 545 <210> 643 <211> 209 <212> PRT <213> Homo sapiens <400> 643 Met Asn Pro Ser Met Lys Gln Lys Gln Glu Glu Ile Lys Glu Asn Ile 1 5 10 15 Lys Asn Ser Ser Val Pro Arg Arg Thr Leu Lys Met Ile Gln Pro Ser 20 25 30 Ala Ser Gly Ser Leu Val Gly Arg Glu Asn Glu Leu Ser Ala Gly Leu 35 40 45 Ser Lys Arg Lys His Arg Asn Asp His Leu Thr Ser Thr Thr Ser Ser 50 55 60 Pro Gly Val Ile Val Pro Glu Ser Ser Glu Asn Lys Asn Leu Gly Gly 65 70 75 80 Val Thr Gln Glu Ser Phe Asp Leu Met Ile Lys Glu Asn Pro Ser Ser 85 90 95 Gln Tyr Trp Lys Glu Val Ala Glu Lys Arg Arg Lys Ala Leu Tyr Glu 100 105 110 Ala Leu Lys Glu Asn Glu Lys Leu His Lys Glu Ile Glu Gln Lys Asp 115 120 125 Asn Glu Ile Ala Arg Leu Lys Lys Glu Asn Lys Glu Leu Ala Glu Val 130 135 140 Ala Glu His Val Gln Tyr Met Ala Glu Leu Ile Glu Arg Leu Asn Gly 145 150 155 160 Glu Pro Leu Asp Asn Phe Glu Ser Leu Asp Asn Gln Glu Phe Asp Ser 165 170 175 Glu Glu Glu Thr Val Glu Asp Ser Leu Val Glu Asp Ser Glu Ile Gly 180 185 190 Thr Cys Ala Glu Gly Thr Val Ser Ser Ser Thr Asp Ala Lys Pro Cys 195 200 205 Ile <210> 644 <211> 808 <212> PRT <213> Homo sapiens <400> 644 Met Ala Gly Thr Val Val Leu Asp Asp Val Glu Leu Arg Glu Ala Gln 1 5 10 15 Arg Asp Tyr Leu Asp Phe Leu Asp Asp Glu Glu Asp Gln Gly Ile Tyr 20 25 30 Gln Ser Lys Val Arg Glu Leu Ile Ser Asp Asn Gln Tyr Arg Leu Ile 35 40 45 Val Asn Val Asn Asp Leu Arg Arg Lys Asn Glu Lys Arg Ala Asn Arg 50 55 60 Leu Leu Asn Asn Ala Phe Glu Glu Leu Val Ala Phe Gln Arg Ala Leu 65 70 75 80 Lys Asp Phe Val Ala Ser Ile Asp Ala Thr Tyr Ala Lys Gln Tyr Glu 85 90 95 Glu Phe Tyr Val Gly Leu Glu Gly Ser Phe Gly Ser Lys His Val Ser 100 105 110 Pro Arg Thr Leu Thr Ser Cys Phe Leu Ser Cys Val Val Cys Val Glu 115 120 125 Gly Ile Val Thr Lys Cys Ser Leu Val Arg Pro Lys Val Val Arg Ser 130 135 140 Val His Tyr Cys Pro Ala Thr Lys Lys Thr Ile Glu Arg Arg Tyr Ser 145 150 155 160 Asp Leu Thr Thr Leu Val Ala Phe Pro Ser Ser Ser Val Tyr Pro Thr 165 170 175 Lys Asp Glu Glu Asn Asn Pro Leu Glu Thr Glu Tyr Gly Leu Ser Val 180 185 190 Tyr Lys Asp His Gln Thr Ile Thr Ile Gln Glu Met Pro Glu Lys Ala 195 200 205 Pro Ala Gly Gln Leu Pro Arg Ser Val Asp Val Ile Leu Asp Asp Asp 210 215 220 Leu Val Asp Lys Ala Lys Pro Gly Asp Arg Val Gln Val Val Gly Thr 225 230 235 240 Tyr Arg Cys Leu Pro Gly Lys Lys Gly Gly Tyr Thr Ser Gly Thr Phe 245 250 255 Arg Thr Val Leu Ile Ala Cys Asn Val Lys Gln Met Ser Lys Asp Ala 260 265 270 Gln Pro Ser Phe Ser Ala Glu Asp Ile Ala Lys Ile Lys Lys Phe Ser 275 280 285 Lys Thr Arg Ser Lys Asp Ile Phe Asp Gln Leu Ala Lys Ser Leu Ala 290 295 300 Pro Ser Ile His Gly His Asp Tyr Val Lys Lys Ala Ile Leu Cys Leu 305 310 315 320 Leu Leu Gly Gly Val Glu Arg Asp Leu Glu Asn Gly Ser His Ile Arg 325 330 335 Gly Asp Ile Asn Ile Leu Leu Ile Gly Asp Pro Ser Val Ala Lys Ser 340 345 350 Gln Leu Leu Arg Tyr Val Leu Cys Thr Ala Pro Arg Ala Ile Pro Thr 355 360 365 Thr Gly Arg Gly Ser Ser Gly Val Gly Leu Thr Ala Ala Val Thr Thr 370 375 380 Asp Gln Glu Thr Gly Glu Arg Arg Leu Glu Ala Gly Ala Met Val Leu 385 390 395 400 Ala Asp Arg Gly Val Val Cys Ile Asp Glu Phe Asp Lys Met Ser Asp 405 410 415 Met Asp Arg Thr Ala Ile His Glu Val Met Glu Gln Gly Arg Val Thr 420 425 430 Ile Ala Lys Ala Gly Ile His Ala Arg Leu Asn Ala Arg Cys Ser Val 435 440 445 Leu Ala Ala Ala Asn Pro Val Tyr Gly Arg Tyr Asp Gln Tyr Lys Thr 450 455 460 Pro Met Glu Asn Ile Gly Leu Gln Asp Ser Leu Leu Ser Arg Phe Asp 465 470 475 480 Leu Leu Phe Ile Met Leu Asp Gln Met Asp Pro Glu Gln Asp Arg Glu 485 490 495 Ile Ser Asp His Val Leu Arg Met His Arg Tyr Arg Ala Pro Gly Glu 500 505 510 Gln Asp Gly Asp Ala Met Pro Leu Gly Ser Ala Val Asp Ile Leu Ala 515 520 525 Thr Asp Asp Pro Asn Phe Ser Gln Glu Asp Gln Gln Asp Thr Gln Ile 530 535 540 Tyr Glu Lys His Asp Asn Leu Leu His Gly Thr Lys Lys Lys Lys Glu 545 550 555 560 Lys Met Val Ser Ala Ala Phe Met Lys Lys Tyr Ile His Val Ala Lys 565 570 575 Ile Ile Lys Pro Val Leu Thr Gln Glu Ser Ala Thr Tyr Ile Ala Glu 580 585 590 Glu Tyr Ser Arg Leu Arg Ser Gln Asp Ser Met Ser Ser Asp Thr Ala 595 600 605 Arg Thr Ser Pro Val Thr Ala Arg Thr Leu Glu Thr Leu Ile Arg Leu 610 615 620 Ala Thr Ala His Ala Lys Ala Arg Met Ser Lys Thr Val Asp Leu Gln 625 630 635 640 Asp Ala Glu Glu Ala Val Glu Leu Val Gln Tyr Ala Tyr Phe Lys Lys 645 650 655 Val Leu Glu Lys Glu Lys Lys Arg Lys Lys Arg Ser Glu Asp Glu Ser 660 665 670 Glu Thr Glu Asp Glu Glu Glu Lys Ser Gln Glu Asp Gln Glu Gln Lys 675 680 685 Arg Lys Arg Arg Lys Thr Arg Gln Pro Asp Ala Lys Asp Gly Asp Ser 690 695 700 Tyr Asp Pro Tyr Asp Phe Ser Asp Thr Glu Glu Glu Met Pro Gln Val 705 710 715 720 His Thr Pro Lys Thr Ala Asp Ser Gln Glu Thr Lys Glu Ser Gln Lys 725 730 735 Val Glu Leu Ser Glu Ser Arg Leu Lys Ala Phe Lys Val Ala Leu Leu 740 745 750 Asp Val Phe Arg Glu Ala His Ala Gln Ser Ile Gly Met Asn Arg Leu 755 760 765 Thr Glu Ser Ile Asn Arg Asp Ser Glu Glu Pro Phe Ser Ser Val Glu 770 775 780 Ile Gln Ala Ala Leu Ser Lys Met Gln Asp Asp Asn Gln Val Met Val 785 790 795 800 Ser Glu Gly Ile Ile Phe Leu Ile 805 <210> 645 <211> 863 <212> PRT <213> Homo sapiens <400> 645 Met Ser Ser Pro Ala Ser Thr Pro Ser Arg Arg Gly Ser Arg Arg Gly 1 5 10 15 Arg Ala Thr Pro Ala Gln Thr Pro Arg Ser Glu Asp Ala Arg Ser Ser 20 25 30 Pro Ser Gln Arg Arg Arg Gly Glu Asp Ser Thr Ser Thr Gly Glu Leu 35 40 45 Gln Pro Met Pro Thr Ser Pro Gly Val Asp Leu Gln Ser Pro Ala Ala 50 55 60 Gln Asp Val Leu Phe Ser Ser Pro Pro Gln Met His Ser Ser Ala Ile 65 70 75 80 Pro Leu Asp Phe Asp Val Ser Ser Pro Leu Thr Tyr Gly Thr Pro Ser 85 90 95 Ser Arg Val Glu Gly Thr Pro Arg Ser Gly Val Arg Gly Thr Pro Val 100 105 110 Arg Gln Arg Pro Asp Leu Gly Ser Ala Gln Lys Gly Leu Gln Val Asp 115 120 125 Leu Gln Ser Asp Gly Ala Ala Ala Glu Asp Ile Val Ala Ser Glu Gln 130 135 140 Ser Leu Gly Gln Lys Leu Val Ile Trp Gly Thr Asp Val Asn Val Ala 145 150 155 160 Ala Cys Lys Glu Asn Phe Gln Arg Phe Leu Gln Arg Phe Ile Asp Pro 165 170 175 Leu Ala Lys Glu Glu Glu Asn Val Gly Ile Asp Ile Thr Glu Pro Leu 180 185 190 Tyr Met Gln Arg Leu Gly Glu Ile Asn Val Ile Gly Glu Pro Phe Leu 195 200 205 Asn Val Asn Cys Glu His Ile Lys Ser Phe Asp Lys Asn Leu Tyr Arg 210 215 220 Gln Leu Ile Ser Tyr Pro Gln Glu Val Ile Pro Thr Phe Asp Met Ala 225 230 235 240 Val Asn Glu Ile Phe Phe Asp Arg Tyr Pro Asp Ser Ile Leu Glu His 245 250 255 Gln Ile Gln Val Arg Pro Phe Asn Ala Leu Lys Thr Lys Asn Met Arg 260 265 270 Asn Leu Asn Pro Glu Asp Ile Asp Gln Leu Ile Thr Ile Ser Gly Met 275 280 285 Val Ile Arg Thr Ser Gln Leu Ile Pro Glu Met Gln Glu Ala Phe Phe 290 295 300 Gln Cys Gln Val Cys Ala His Thr Thr Arg Val Glu Met Asp Arg Gly 305 310 315 320 Arg Ile Ala Glu Pro Ser Val Cys Gly Arg Cys His Thr Thr His Ser 325 330 335 Met Ala Leu Ile His Asn Arg Ser Leu Phe Ser Asp Lys Gln Met Ile 340 345 350 Lys Leu Gln Glu Ser Pro Glu Asp Met Pro Ala Gly Gln Thr Pro His 355 360 365 Thr Val Ile Leu Phe Ala His Asn Asp Leu Val Asp Lys Val Gln Pro 370 375 380 Gly Asp Arg Val Asn Val Thr Gly Ile Tyr Arg Ala Val Pro Ile Arg 385 390 395 400 Val Asn Pro Arg Val Ser Asn Val Lys Ser Val Tyr Lys Thr His Ile 405 410 415 Asp Val Ile His Tyr Arg Lys Thr Asp Ala Lys Arg Leu His Gly Leu 420 425 430 Asp Glu Glu Ala Glu Gln Lys Leu Phe Ser Glu Lys Arg Val Glu Leu 435 440 445 Leu Lys Glu Leu Ser Arg Lys Pro Asp Ile Tyr Glu Arg Leu Ala Ser 450 455 460 Ala Leu Ala Pro Ser Ile Tyr Glu His Glu Asp Ile Lys Lys Gly Ile 465 470 475 480 Leu Leu Gln Leu Phe Gly Gly Thr Arg Lys Asp Phe Ser His Thr Gly 485 490 495 Arg Gly Lys Phe Arg Ala Glu Ile Asn Ile Leu Leu Cys Gly Asp Pro 500 505 510 Gly Thr Ser Lys Ser Gln Leu Leu Gln Tyr Val Tyr Asn Leu Val Pro 515 520 525 Arg Gly Gln Tyr Thr Ser Gly Lys Gly Ser Ser Ala Val Gly Leu Thr 530 535 540 Ala Tyr Val Met Lys Asp Pro Glu Thr Arg Gln Leu Val Leu Gln Thr 545 550 555 560 Gly Ala Leu Val Leu Ser Asp Asn Gly Ile Cys Cys Ile Asp Glu Phe 565 570 575 Asp Lys Met Asn Glu Ser Thr Arg Ser Val Leu His Glu Val Met Glu 580 585 590 Gln Gln Thr Leu Ser Ile Ala Lys Ala Gly Ile Ile Cys Gln Leu Asn 595 600 605 Ala Arg Thr Ser Val Leu Ala Ala Ala Asn Pro Ile Glu Ser Gln Trp 610 615 620 Asn Pro Lys Lys Thr Thr Ile Glu Asn Ile Gln Leu Pro His Thr Leu 625 630 635 640 Leu Ser Arg Phe Asp Leu Ile Phe Leu Leu Leu Asp Pro Gln Asp Glu 645 650 655 Ala Tyr Asp Arg Arg Leu Ala His His Leu Val Ala Leu Tyr Tyr Gln 660 665 670 Ser Glu Glu Gln Ala Glu Glu Glu Leu Leu Asp Met Ala Val Leu Lys 675 680 685 Asp Tyr Ile Ala Tyr Ala His Ser Thr Ile Met Pro Arg Leu Ser Glu 690 695 700 Glu Ala Ser Gln Ala Leu Ile Glu Ala Tyr Val Asp Met Arg Lys Ile 705 710 715 720 Gly Ser Ser Arg Gly Met Val Ser Ala Tyr Pro Arg Gln Leu Glu Ser 725 730 735 Leu Ile Arg Leu Ala Glu Ala His Ala Lys Val Arg Leu Ser Asn Lys 740 745 750 Val Glu Ala Ile Asp Val Glu Glu Ala Lys Arg Leu His Arg Glu Ala 755 760 765 Leu Lys Gln Ser Ala Thr Asp Pro Arg Thr Gly Ile Val Asp Ile Ser 770 775 780 Ile Leu Thr Thr Gly Met Ser Ala Thr Ser Arg Lys Arg Lys Glu Glu 785 790 795 800 Leu Ala Glu Ala Leu Lys Lys Leu Ile Leu Ser Lys Gly Lys Thr Pro 805 810 815 Ala Leu Lys Tyr Gln Gln Leu Phe Glu Asp Ile Arg Gly Gln Ser Asp 820 825 830 Ile Ala Ile Thr Lys Asp Met Phe Glu Glu Ala Leu Arg Ala Leu Ala 835 840 845 Asp Asp Asp Phe Leu Thr Val Thr Gly Lys Thr Val Arg Leu Leu 850 855 860 <210> 646 <211> 734 <212> PRT <213> Homo sapiens <400> 646 Met Ser Gly Phe Asp Asp Pro Gly Ile Phe Tyr Ser Asp Ser Phe Gly 1 5 10 15 Gly Asp Ala Gln Ala Asp Glu Gly Gln Ala Arg Lys Ser Gln Leu Gln 20 25 30 Arg Arg Phe Lys Glu Phe Leu Arg Gln Tyr Arg Val Gly Thr Asp Arg 35 40 45 Thr Gly Phe Thr Phe Lys Tyr Arg Asp Glu Leu Lys Arg His Tyr Asn 50 55 60 Leu Gly Glu Tyr Trp Ile Glu Val Glu Met Glu Asp Leu Ala Ser Phe 65 70 75 80 Asp Glu Asp Leu Ala Asp Tyr Leu Tyr Lys Gln Pro Ala Glu His Leu 85 90 95 Gln Leu Leu Glu Glu Ala Ala Lys Glu Val Ala Asp Glu Val Thr Arg 100 105 110 Pro Arg Pro Ser Gly Glu Glu Val Leu Gln Asp Ile Gln Val Met Leu 115 120 125 Lys Ser Asp Ala Ser Pro Ser Ser Ile Arg Ser Leu Lys Ser Asp Met 130 135 140 Met Ser His Leu Val Lys Ile Pro Gly Ile Ile Ile Ala Ala Ser Ala 145 150 155 160 Val Arg Ala Lys Ala Thr Arg Ile Ser Ile Gln Cys Arg Ser Cys Arg 165 170 175 Asn Thr Leu Thr Asn Ile Ala Met Arg Pro Gly Leu Glu Gly Tyr Ala 180 185 190 Leu Pro Arg Lys Cys Asn Thr Asp Gln Ala Gly Arg Pro Lys Cys Pro 195 200 205 Leu Asp Pro Tyr Phe Ile Met Pro Asp Lys Cys Lys Cys Val Asp Phe 210 215 220 Gln Thr Leu Lys Leu Gln Glu Leu Pro Asp Ala Val Pro His Gly Glu 225 230 235 240 Met Pro Arg His Met Gln Leu Tyr Cys Asp Arg Tyr Leu Cys Asp Lys 245 250 255 Val Val Pro Gly Asn Arg Val Thr Ile Met Gly Ile Tyr Ser Ile Lys 260 265 270 Lys Phe Gly Leu Thr Thr Ser Arg Gly Arg Asp Arg Val Gly Val Gly 275 280 285 Ile Arg Ser Ser Tyr Ile Arg Val Leu Gly Ile Gln Val Asp Thr Asp 290 295 300 Gly Ser Gly Arg Ser Phe Ala Gly Ala Val Ser Pro Gln Glu Glu Glu 305 310 315 320 Glu Phe Arg Arg Leu Ala Ala Leu Pro Asn Val Tyr Glu Val Ile Ser 325 330 335 Lys Ser Ile Ala Pro Ser Ile Phe Gly Gly Thr Asp Met Lys Lys Ala 340 345 350 Ile Ala Cys Leu Leu Phe Gly Gly Ser Arg Lys Arg Leu Pro Asp Gly 355 360 365 Leu Thr Arg Arg Gly Asp Ile Asn Leu Leu Met Leu Gly Asp Pro Gly 370 375 380 Thr Ala Lys Ser Gln Leu Leu Lys Phe Val Glu Lys Cys Ser Pro Ile 385 390 395 400 Gly Val Tyr Thr Ser Gly Lys Gly Ser Ser Ala Ala Gly Leu Thr Ala 405 410 415 Ser Val Met Arg Asp Pro Ser Ser Arg Asn Phe Ile Met Glu Gly Gly 420 425 430 Ala Met Val Leu Ala Asp Gly Gly Val Val Cys Ile Asp Glu Phe Asp 435 440 445 Lys Met Arg Glu Asp Asp Arg Val Ala Ile His Glu Ala Met Glu Gln 450 455 460 Gln Thr Ile Ser Ile Ala Lys Ala Gly Ile Thr Thr Thr Leu Asn Ser 465 470 475 480 Arg Cys Ser Val Leu Ala Ala Ala Asn Ser Val Phe Gly Arg Trp Asp 485 490 495 Glu Thr Lys Gly Glu Asp Asn Ile Asp Phe Met Pro Thr Ile Leu Ser 500 505 510 Arg Phe Asp Met Ile Phe Ile Val Lys Asp Glu His Asn Glu Glu Arg 515 520 525 Asp Val Met Leu Ala Lys His Val Ile Thr Leu His Val Ser Ala Leu 530 535 540 Thr Gln Thr Gln Ala Val Glu Gly Glu Ile Asp Leu Ala Lys Leu Lys 545 550 555 560 Lys Phe Ile Ala Tyr Cys Arg Val Lys Cys Gly Pro Arg Leu Ser Ala 565 570 575 Glu Ala Ala Glu Lys Leu Lys Asn Arg Tyr Ile Ile Met Arg Ser Gly 580 585 590 Ala Arg Gln His Glu Arg Asp Ser Asp Arg Arg Ser Ser Ile Pro Ile 595 600 605 Thr Val Arg Gln Leu Glu Ala Ile Val Arg Ile Ala Glu Ala Leu Ser 610 615 620 Lys Met Lys Leu Gln Pro Phe Ala Thr Glu Ala Asp Val Glu Glu Ala 625 630 635 640 Leu Arg Leu Phe Gln Val Ser Thr Leu Asp Ala Ala Leu Ser Gly Thr 645 650 655 Leu Ser Gly Val Glu Gly Phe Thr Ser Gln Glu Asp Gln Glu Met Leu 660 665 670 Ser Arg Ile Glu Lys Gln Leu Lys Arg Arg Phe Ala Ile Gly Ser Gln 675 680 685 Val Ser Glu His Ser Ile Ile Lys Asp Phe Thr Lys Gln Lys Tyr Pro 690 695 700 Glu His Ala Ile His Lys Val Leu Gln Leu Met Leu Arg Arg Gly Glu 705 710 715 720 Ile Gln His Arg Met Gln Arg Lys Val Leu Tyr Arg Leu Lys 725 730 <210> 647 <211> 821 <212> PRT <213> Homo sapiens <400> 647 Met Asp Leu Ala Ala Ala Ala Glu Pro Gly Ala Gly Ser Gln His Leu 1 5 10 15 Glu Val Arg Asp Glu Val Ala Glu Lys Cys Gln Lys Leu Phe Leu Asp 20 25 30 Phe Leu Glu Glu Phe Gln Ser Ser Asp Gly Glu Ile Lys Tyr Leu Gln 35 40 45 Leu Ala Glu Glu Leu Ile Arg Pro Glu Arg Asn Thr Leu Val Val Ser 50 55 60 Phe Val Asp Leu Glu Gln Phe Asn Gln Gln Leu Ser Thr Thr Ile Gln 65 70 75 80 Glu Glu Phe Tyr Arg Val Tyr Pro Tyr Leu Cys Arg Ala Leu Lys Thr 85 90 95 Phe Val Lys Asp Arg Lys Glu Ile Pro Leu Ala Lys Asp Phe Tyr Val 100 105 110 Ala Phe Gln Asp Leu Pro Thr Arg His Lys Ile Arg Glu Leu Thr Ser 115 120 125 Ser Arg Ile Gly Leu Leu Thr Arg Ile Ser Gly Gln Val Val Arg Thr 130 135 140 His Pro Val His Pro Glu Leu Val Ser Gly Thr Phe Leu Cys Leu Asp 145 150 155 160 Cys Gln Thr Val Ile Arg Asp Val Glu Gln Gln Phe Lys Tyr Thr Gln 165 170 175 Pro Asn Ile Cys Arg Asn Pro Val Cys Ala Asn Arg Arg Arg Phe Leu 180 185 190 Leu Asp Thr Asn Lys Ser Arg Phe Val Asp Phe Gln Lys Val Arg Ile 195 200 205 Gln Glu Thr Gln Ala Glu Leu Pro Arg Gly Ser Ile Pro Arg Ser Leu 210 215 220 Glu Val Ile Leu Arg Ala Glu Ala Val Glu Ser Ala Gln Ala Gly Asp 225 230 235 240 Lys Cys Asp Phe Thr Gly Thr Leu Ile Val Val Pro Asp Val Ser Lys 245 250 255 Leu Ser Thr Pro Gly Ala Arg Ala Glu Thr Asn Ser Arg Val Ser Gly 260 265 270 Val Asp Gly Tyr Glu Thr Glu Gly Ile Arg Gly Leu Arg Ala Leu Gly 275 280 285 Val Arg Asp Leu Ser Tyr Arg Leu Val Phe Leu Ala Cys Cys Val Ala 290 295 300 Pro Thr Asn Pro Arg Phe Gly Gly Lys Glu Leu Arg Asp Glu Glu Gln 305 310 315 320 Thr Ala Glu Ser Ile Lys Asn Gln Met Thr Val Lys Glu Trp Glu Lys 325 330 335 Val Phe Glu Met Ser Gln Asp Lys Asn Leu Tyr His Asn Leu Cys Thr 340 345 350 Ser Leu Phe Pro Thr Ile His Gly Asn Asp Glu Val Lys Arg Gly Val 355 360 365 Leu Leu Met Leu Phe Gly Gly Val Pro Lys Thr Thr Gly Glu Gly Thr 370 375 380 Ser Leu Arg Gly Asp Ile Asn Val Cys Ile Val Gly Asp Pro Ser Thr 385 390 395 400 Ala Lys Ser Gln Phe Leu Lys His Val Glu Glu Phe Ser Pro Arg Ala 405 410 415 Val Tyr Thr Ser Gly Lys Ala Ser Ser Ala Ala Gly Leu Thr Ala Ala 420 425 430 Val Val Arg Asp Glu Glu Ser His Glu Phe Val Ile Glu Ala Gly Ala 435 440 445 Leu Met Leu Ala Asp Asn Gly Val Cys Cys Ile Asp Glu Phe Asp Lys 450 455 460 Met Asp Val Arg Asp Gln Val Ala Ile His Glu Ala Met Glu Gln Gln 465 470 475 480 Thr Ile Ser Ile Thr Lys Ala Gly Val Lys Ala Thr Leu Asn Ala Arg 485 490 495 Thr Ser Ile Leu Ala Ala Ala Asn Pro Ile Ser Gly His Tyr Asp Arg 500 505 510 Ser Lys Ser Leu Lys Gln Asn Ile Asn Leu Ser Ala Pro Ile Met Ser 515 520 525 Arg Phe Asp Leu Phe Phe Ile Leu Val Asp Glu Cys Asn Glu Val Thr 530 535 540 Asp Tyr Ala Ile Ala Arg Arg Ile Val Asp Leu His Ser Arg Ile Glu 545 550 555 560 Glu Ser Ile Asp Arg Val Tyr Ser Leu Asp Asp Ile Arg Arg Tyr Leu 565 570 575 Leu Phe Ala Arg Gln Phe Lys Pro Lys Ile Ser Lys Glu Ser Glu Asp 580 585 590 Phe Ile Val Glu Gln Tyr Lys His Leu Arg Gln Arg Asp Gly Ser Gly 595 600 605 Val Thr Lys Ser Ser Trp Arg Ile Thr Val Arg Gln Leu Glu Ser Met 610 615 620 Ile Arg Leu Ser Glu Ala Met Ala Arg Met His Cys Cys Asp Glu Val 625 630 635 640 Gln Pro Lys His Val Lys Glu Ala Phe Arg Leu Leu Asn Lys Ser Ile 645 650 655 Ile Arg Val Glu Thr Pro Asp Val Asn Leu Asp Gln Glu Glu Glu Ile 660 665 670 Gln Met Glu Val Asp Glu Gly Ala Gly Gly Ile Asn Gly His Ala Asp 675 680 685 Ser Pro Ala Pro Val Asn Gly Ile Asn Gly Tyr Asn Glu Asp Ile Asn 690 695 700 Gln Glu Ser Ala Pro Lys Ala Ser Leu Arg Leu Gly Phe Ser Glu Tyr 705 710 715 720 Cys Arg Ile Ser Asn Leu Ile Val Leu His Leu Arg Lys Val Glu Glu 725 730 735 Glu Glu Asp Glu Ser Ala Leu Lys Arg Ser Glu Leu Val Asn Trp Tyr 740 745 750 Leu Lys Glu Ile Glu Ser Glu Ile Asp Ser Glu Glu Glu Leu Ile Asn 755 760 765 Lys Lys Arg Ile Ile Glu Lys Val Ile His Arg Leu Thr His Tyr Asp 770 775 780 His Val Leu Ile Glu Leu Thr Gln Ala Gly Leu Lys Gly Ser Thr Glu 785 790 795 800 Gly Ser Glu Ser Tyr Glu Glu Asp Pro Tyr Leu Val Val Asn Pro Asn 805 810 815 Tyr Leu Leu Glu Asp 820 <210> 648 <211> 719 <212> PRT <213> Homo sapiens <400> 648 Met Ala Leu Lys Asp Tyr Ala Leu Glu Lys Glu Lys Val Lys Lys Phe 1 5 10 15 Leu Gln Glu Phe Tyr Gln Asp Asp Glu Leu Gly Lys Lys Gln Phe Lys 20 25 30 Tyr Gly Asn Gln Leu Val Arg Leu Ala His Arg Glu Gln Val Ala Leu 35 40 45 Tyr Val Asp Leu Asp Asp Val Ala Glu Asp Asp Pro Glu Leu Val Asp 50 55 60 Ser Ile Cys Glu Asn Ala Arg Arg Tyr Ala Lys Leu Phe Ala Asp Ala 65 70 75 80 Val Gln Glu Leu Leu Pro Gln Tyr Lys Glu Arg Glu Val Val Asn Lys 85 90 95 Asp Val Leu Asp Val Tyr Ile Glu His Arg Leu Met Met Glu Gln Arg 100 105 110 Ser Arg Asp Pro Gly Met Val Arg Ser Pro Gln Asn Gln Tyr Pro Ala 115 120 125 Glu Leu Met Arg Arg Phe Glu Leu Tyr Phe Gln Gly Pro Ser Ser Asn 130 135 140 Lys Pro Arg Val Ile Arg Glu Val Arg Ala Asp Ser Val Gly Lys Leu 145 150 155 160 Val Thr Val Arg Gly Ile Val Thr Arg Val Ser Glu Val Lys Pro Lys 165 170 175 Met Val Val Ala Thr Tyr Thr Cys Asp Gln Cys Gly Ala Glu Thr Tyr 180 185 190 Gln Pro Ile Gln Ser Pro Thr Phe Met Pro Leu Ile Met Cys Pro Ser 195 200 205 Gln Glu Cys Gln Thr Asn Arg Ser Gly Gly Arg Leu Tyr Leu Gln Thr 210 215 220 Arg Gly Ser Arg Phe Ile Lys Phe Gln Glu Met Lys Met Gln Glu His 225 230 235 240 Ser Asp Gln Val Pro Val Gly Asn Ile Pro Arg Ser Ile Thr Val Leu 245 250 255 Val Glu Gly Glu Asn Thr Arg Ile Ala Gln Pro Gly Asp His Val Ser 260 265 270 Val Thr Gly Ile Phe Leu Pro Ile Leu Arg Thr Gly Phe Arg Gln Val 275 280 285 Val Gln Gly Leu Leu Ser Glu Thr Tyr Leu Glu Ala His Arg Ile Val 290 295 300 Lys Met Asn Lys Ser Glu Asp Asp Glu Ser Gly Ala Gly Glu Leu Thr 305 310 315 320 Arg Glu Glu Leu Arg Gln Ile Ala Glu Glu Asp Phe Tyr Glu Lys Leu 325 330 335 Ala Ala Ser Ile Ala Pro Glu Ile Tyr Gly His Glu Asp Val Lys Lys 340 345 350 Ala Leu Leu Leu Leu Leu Val Gly Gly Val Asp Gln Ser Pro Arg Gly 355 360 365 Met Lys Ile Arg Gly Asn Ile Asn Ile Cys Leu Met Gly Asp Pro Gly 370 375 380 Val Ala Lys Ser Gln Leu Leu Ser Tyr Ile Asp Arg Leu Ala Pro Arg 385 390 395 400 Ser Gln Tyr Thr Thr Gly Arg Gly Ser Ser Gly Val Gly Leu Thr Ala 405 410 415 Ala Val Leu Arg Asp Ser Val Ser Gly Glu Leu Thr Leu Glu Gly Gly 420 425 430 Ala Leu Val Leu Ala Asp Gln Gly Val Cys Cys Ile Asp Glu Phe Asp 435 440 445 Lys Met Ala Glu Ala Asp Arg Thr Ala Ile His Glu Val Met Glu Gln 450 455 460 Gln Thr Ile Ser Ile Ala Lys Ala Gly Ile Leu Thr Thr Leu Asn Ala 465 470 475 480 Arg Cys Ser Ile Leu Ala Ala Ala Asn Pro Ala Tyr Gly Arg Tyr Asn 485 490 495 Pro Arg Arg Ser Leu Glu Gln Asn Ile Gln Leu Pro Ala Ala Leu Leu 500 505 510 Ser Arg Phe Asp Leu Leu Trp Leu Ile Gln Asp Arg Pro Asp Arg Asp 515 520 525 Asn Asp Leu Arg Leu Ala Gln His Ile Thr Tyr Val His Gln His Ser 530 535 540 Arg Gln Pro Pro Ser Gln Phe Glu Pro Leu Asp Met Lys Leu Met Arg 545 550 555 560 Arg Tyr Ile Ala Met Cys Arg Glu Lys Gln Pro Met Val Pro Glu Ser 565 570 575 Leu Ala Asp Tyr Ile Thr Ala Ala Tyr Val Glu Met Arg Arg Glu Ala 580 585 590 Trp Ala Ser Lys Asp Ala Thr Tyr Thr Ser Ala Arg Thr Leu Leu Ala 595 600 605 Ile Leu Arg Leu Ser Thr Ala Leu Ala Arg Leu Arg Met Val Asp Val 610 615 620 Val Glu Lys Glu Asp Val Asn Glu Ala Ile Arg Leu Met Glu Met Ser 625 630 635 640 Lys Asp Ser Leu Leu Gly Asp Lys Gly Gln Thr Ala Arg Thr Gln Arg 645 650 655 Pro Ala Asp Val Ile Phe Ala Thr Val Arg Glu Leu Val Ser Gly Gly 660 665 670 Arg Ser Val Arg Phe Ser Glu Ala Glu Gln Arg Cys Val Ser Arg Gly 675 680 685 Phe Thr Pro Ala Gln Phe Gln Ala Ala Leu Asp Glu Tyr Glu Glu Leu 690 695 700 Asn Val Trp Gln Val Asn Ala Ser Arg Thr Arg Ile Thr Phe Val 705 710 715 <210> 649 <211> 840 <212> PRT <213> Homo sapiens <400> 649 Met Asn Gly Glu Tyr Arg Gly Arg Gly Phe Gly Arg Gly Arg Phe Gln 1 5 10 15 Ser Trp Lys Arg Gly Arg Gly Gly Gly Asn Phe Ser Gly Lys Trp Arg 20 25 30 Glu Arg Glu His Arg Pro Asp Leu Ser Lys Thr Thr Gly Lys Arg Thr 35 40 45 Ser Glu Gln Thr Pro Gln Phe Leu Leu Ser Thr Lys Thr Pro Gln Ser 50 55 60 Met Gln Ser Thr Leu Asp Arg Phe Ile Pro Tyr Lys Gly Trp Lys Leu 65 70 75 80 Tyr Phe Ser Glu Val Tyr Ser Asp Ser Ser Pro Leu Ile Glu Lys Ile 85 90 95 Gln Ala Phe Glu Lys Phe Phe Thr Arg His Ile Asp Leu Tyr Asp Lys 100 105 110 Asp Glu Ile Glu Arg Lys Gly Ser Ile Leu Val Asp Phe Lys Glu Leu 115 120 125 Thr Glu Gly Gly Glu Val Thr Asn Leu Ile Pro Asp Ile Ala Thr Glu 130 135 140 Leu Arg Asp Ala Pro Glu Lys Thr Leu Ala Cys Met Gly Leu Ala Ile 145 150 155 160 His Gln Val Leu Thr Lys Asp Leu Glu Arg His Ala Ala Glu Leu Gln 165 170 175 Ala Gln Glu Gly Leu Ser Asn Asp Gly Glu Thr Met Val Asn Val Pro 180 185 190 His Ile His Ala Arg Val Tyr Asn Tyr Glu Pro Leu Thr Gln Leu Lys 195 200 205 Asn Val Arg Ala Asn Tyr Tyr Gly Lys Tyr Ile Ala Leu Arg Gly Thr 210 215 220 Val Val Arg Val Ser Asn Ile Lys Pro Leu Cys Thr Lys Met Ala Phe 225 230 235 240 Leu Cys Ala Ala Cys Gly Glu Ile Gln Ser Phe Pro Leu Pro Asp Gly 245 250 255 Lys Tyr Ser Leu Pro Thr Lys Cys Pro Val Pro Val Cys Arg Gly Arg 260 265 270 Ser Phe Thr Ala Leu Arg Ser Ser Pro Leu Thr Val Thr Met Asp Trp 275 280 285 Gln Ser Ile Lys Ile Gln Glu Leu Met Ser Asp Asp Gln Arg Glu Ala 290 295 300 Gly Arg Ile Pro Arg Thr Ile Glu Cys Glu Leu Val His Asp Leu Val 305 310 315 320 Asp Ser Cys Val Pro Gly Asp Thr Val Thr Ile Thr Gly Ile Val Lys 325 330 335 Val Ser Asn Ala Glu Glu Gly Ser Arg Asn Lys Asn Asp Lys Cys Met 340 345 350 Phe Leu Leu Tyr Ile Glu Ala Asn Ser Ile Ser Asn Ser Lys Gly Gln 355 360 365 Lys Thr Lys Ser Ser Glu Asp Gly Cys Lys His Gly Met Leu Met Glu 370 375 380 Phe Ser Leu Lys Asp Leu Tyr Ala Ile Gln Glu Ile Gln Ala Glu Glu 385 390 395 400 Asn Leu Phe Lys Leu Ile Val Asn Ser Leu Cys Pro Val Ile Phe Gly 405 410 415 His Glu Leu Val Lys Ala Gly Leu Ala Leu Ala Leu Phe Gly Gly Ser 420 425 430 Gln Lys Tyr Ala Asp Asp Lys Asn Arg Ile Pro Ile Arg Gly Asp Pro 435 440 445 His Ile Leu Val Val Gly Asp Pro Gly Leu Gly Lys Ser Gln Met Leu 450 455 460 Gln Ala Ala Cys Asn Val Ala Pro Arg Gly Val Tyr Val Cys Gly Asn 465 470 475 480 Thr Thr Thr Thr Ser Gly Leu Thr Val Thr Leu Ser Lys Asp Ser Ser 485 490 495 Ser Gly Asp Phe Ala Leu Glu Ala Gly Ala Leu Val Leu Gly Asp Gln 500 505 510 Gly Ile Cys Gly Ile Asp Glu Phe Asp Lys Met Gly Asn Gln His Gln 515 520 525 Ala Leu Leu Glu Ala Met Glu Gln Gln Ser Ile Ser Leu Ala Lys Ala 530 535 540 Gly Val Val Cys Ser Leu Pro Ala Arg Thr Ser Ile Ile Ala Ala Ala 545 550 555 560 Asn Pro Val Gly Gly His Tyr Asn Lys Ala Lys Thr Val Ser Glu Asn 565 570 575 Leu Lys Met Gly Ser Ala Leu Leu Ser Arg Phe Asp Leu Val Phe Ile 580 585 590 Leu Leu Asp Thr Pro Asn Glu His His Asp His Leu Leu Ser Glu His 595 600 605 Val Ile Ala Ile Arg Ala Gly Lys Gln Arg Thr Ile Ser Ser Ala Thr 610 615 620 Val Ala Arg Met Asn Ser Gln Asp Ser Asn Thr Ser Val Leu Glu Val 625 630 635 640 Val Ser Glu Lys Pro Leu Ser Glu Arg Leu Lys Val Val Pro Gly Glu 645 650 655 Thr Ile Asp Pro Ile Pro His Gln Leu Leu Arg Lys Tyr Ile Gly Tyr 660 665 670 Ala Arg Gln Tyr Val Tyr Pro Arg Leu Ser Thr Glu Ala Ala Arg Val 675 680 685 Leu Gln Asp Phe Tyr Leu Glu Leu Arg Lys Gln Ser Gln Arg Leu Asn 690 695 700 Ser Ser Pro Ile Thr Thr Arg Gln Leu Glu Ser Leu Ile Arg Leu Thr 705 710 715 720 Glu Ala Arg Ala Arg Leu Glu Leu Arg Glu Glu Ala Thr Lys Glu Asp 725 730 735 Ala Glu Asp Ile Val Glu Ile Met Lys Tyr Ser Met Leu Gly Thr Tyr 740 745 750 Ser Asp Glu Phe Gly Asn Leu Asp Phe Glu Arg Ser Gln His Gly Ser 755 760 765 Gly Met Ser Asn Arg Ser Thr Ala Lys Arg Phe Ile Ser Ala Leu Asn 770 775 780 Asn Val Ala Glu Arg Thr Tyr Asn Asn Ile Phe Gln Phe His Gln Leu 785 790 795 800 Arg Gln Ile Ala Lys Glu Leu Asn Ile Gln Val Ala Asp Phe Glu Asn 805 810 815 Phe Ile Gly Ser Leu Asn Asp Gln Gly Tyr Leu Leu Lys Lys Gly Pro 820 825 830 Lys Val Tyr Gln Leu Gln Thr Met 835 840 <210> 650 <211> 574 <212> PRT <213> Homo sapiens <400> 650 Met Glu Ala Ser Leu Gly Ile Gln Met Asp Glu Pro Met Ala Phe Ser 1 5 10 15 Pro Gln Arg Asp Arg Phe Gln Ala Glu Gly Ser Leu Lys Lys Asn Glu 20 25 30 Gln Asn Phe Lys Leu Ala Gly Val Lys Lys Asp Ile Glu Lys Leu Tyr 35 40 45 Glu Ala Val Pro Gln Leu Ser Asn Val Phe Lys Ile Glu Asp Lys Ile 50 55 60 Gly Glu Gly Thr Phe Ser Ser Val Tyr Leu Ala Thr Ala Gln Leu Gln 65 70 75 80 Val Gly Pro Glu Glu Lys Ile Ala Leu Lys His Leu Ile Pro Thr Ser 85 90 95 His Pro Ile Arg Ile Ala Ala Glu Leu Gln Cys Leu Thr Val Ala Gly 100 105 110 Gly Gln Asp Asn Val Met Gly Val Lys Tyr Cys Phe Arg Lys Asn Asp 115 120 125 His Val Val Ile Ala Met Pro Tyr Leu Glu His Glu Ser Phe Leu Asp 130 135 140 Ile Leu Asn Ser Leu Ser Phe Gln Glu Val Arg Glu Tyr Met Leu Asn 145 150 155 160 Leu Phe Lys Ala Leu Lys Arg Ile His Gln Phe Gly Ile Val His Arg 165 170 175 Asp Val Lys Pro Ser Asn Phe Leu Tyr Asn Arg Arg Leu Lys Lys Tyr 180 185 190 Ala Leu Val Asp Phe Gly Leu Ala Gln Gly Thr His Asp Thr Lys Ile 195 200 205 Glu Leu Leu Lys Phe Val Gln Ser Glu Ala Gln Gln Glu Arg Cys Ser 210 215 220 Gln Asn Lys Ser His Ile Ile Thr Gly Asn Lys Ile Pro Leu Ser Gly 225 230 235 240 Pro Val Pro Lys Glu Leu Asp Gln Gln Ser Thr Thr Lys Ala Ser Val 245 250 255 Lys Arg Pro Tyr Thr Asn Ala Gln Ile Gln Ile Lys Gln Gly Lys Asp 260 265 270 Gly Lys Glu Gly Ser Val Gly Leu Ser Val Gln Arg Ser Val Phe Gly 275 280 285 Glu Arg Asn Phe Asn Ile His Ser Ser Ile Ser His Glu Ser Pro Ala 290 295 300 Val Lys Leu Met Lys Gln Ser Lys Thr Val Asp Val Leu Ser Arg Lys 305 310 315 320 Leu Ala Thr Lys Lys Lys Ala Ile Ser Thr Lys Val Met Asn Ser Ala 325 330 335 Val Met Arg Lys Thr Ala Ser Ser Cys Pro Ala Ser Leu Thr Cys Asp 340 345 350 Cys Tyr Ala Thr Asp Lys Val Cys Ser Ile Cys Leu Ser Arg Arg Gln 355 360 365 Gln Val Ala Pro Arg Ala Gly Thr Pro Gly Phe Arg Ala Pro Glu Val 370 375 380 Leu Thr Lys Cys Pro Asn Gln Thr Thr Ala Ile Asp Met Trp Ser Ala 385 390 395 400 Gly Val Ile Phe Leu Ser Leu Leu Ser Gly Arg Tyr Pro Phe Tyr Lys 405 410 415 Ala Ser Asp Asp Leu Thr Ala Leu Ala Gln Ile Met Thr Ile Arg Gly 420 425 430 Ser Arg Glu Thr Ile Gln Ala Ala Lys Thr Phe Gly Lys Ser Ile Leu 435 440 445 Cys Ser Lys Glu Val Pro Ala Gln Asp Leu Arg Lys Leu Cys Glu Arg 450 455 460 Leu Arg Gly Met Asp Ser Ser Thr Pro Lys Leu Thr Ser Asp Ile Gln 465 470 475 480 Gly His Ala Ser His Gln Pro Ala Ile Ser Glu Lys Thr Asp His Lys 485 490 495 Ala Ser Cys Leu Val Gln Thr Pro Pro Gly Gln Tyr Ser Gly Asn Ser 500 505 510 Phe Lys Lys Gly Asp Ser Asn Ser Cys Glu His Cys Phe Asp Glu Tyr 515 520 525 Asn Thr Asn Leu Glu Gly Trp Asn Glu Val Pro Asp Glu Ala Tyr Asp 530 535 540 Leu Leu Asp Lys Leu Leu Asp Leu Asn Pro Ala Ser Arg Ile Thr Ala 545 550 555 560 Glu Glu Ala Leu Leu His Pro Phe Phe Lys Asp Met Ser Leu 565 570 <210> 651 <211> 802 <212> PRT <213> Homo sapiens <400> 651 Met Pro Arg Ile Met Ile Lys Gly Gly Val Trp Arg Asn Thr Glu Asp 1 5 10 15 Glu Ile Leu Lys Ala Ala Val Met Lys Tyr Gly Lys Asn Gln Trp Ser 20 25 30 Arg Ile Ala Ser Leu Leu His Arg Lys Ser Ala Lys Gln Cys Lys Ala 35 40 45 Arg Trp Tyr Glu Trp Leu Asp Pro Ser Ile Lys Lys Thr Glu Trp Ser 50 55 60 Arg Glu Glu Glu Glu Lys Leu Leu His Leu Ala Lys Leu Met Pro Thr 65 70 75 80 Gln Trp Arg Thr Ile Ala Pro Ile Ile Gly Arg Thr Ala Ala Gln Cys 85 90 95 Leu Glu His Tyr Glu Phe Leu Leu Asp Lys Ala Ala Gln Arg Asp Asn 100 105 110 Glu Glu Glu Thr Thr Asp Asp Pro Arg Lys Leu Lys Pro Gly Glu Ile 115 120 125 Asp Pro Asn Pro Glu Thr Lys Pro Ala Arg Pro Asp Pro Ile Asp Met 130 135 140 Asp Glu Asp Glu Leu Glu Met Leu Ser Glu Ala Arg Ala Arg Leu Ala 145 150 155 160 Asn Thr Gln Gly Lys Lys Ala Lys Arg Lys Ala Arg Glu Lys Gln Leu 165 170 175 Glu Glu Ala Arg Arg Leu Ala Ala Leu Gln Lys Arg Arg Glu Leu Arg 180 185 190 Ala Ala Gly Ile Glu Ile Gln Lys Lys Arg Lys Arg Lys Arg Gly Val 195 200 205 Asp Tyr Asn Ala Glu Ile Pro Phe Glu Lys Lys Pro Ala Leu Gly Phe 210 215 220 Tyr Asp Thr Ser Glu Glu Asn Tyr Gln Ala Leu Asp Ala Asp Phe Arg 225 230 235 240 Lys Leu Arg Gln Gln Asp Leu Asp Gly Glu Leu Arg Ser Glu Lys Glu 245 250 255 Gly Arg Asp Arg Lys Lys Asp Lys Gln His Leu Lys Arg Lys Lys Glu 260 265 270 Ser Asp Leu Pro Ser Ala Ile Leu Gln Thr Ser Gly Val Ser Glu Phe 275 280 285 Thr Lys Lys Arg Ser Lys Leu Val Leu Pro Ala Pro Gln Ile Ser Asp 290 295 300 Ala Glu Leu Gln Glu Val Val Lys Val Gly Gln Ala Ser Glu Ile Ala 305 310 315 320 Arg Gln Thr Ala Glu Glu Ser Gly Ile Thr Asn Ser Ala Ser Ser Thr 325 330 335 Leu Leu Ser Glu Tyr Asn Val Thr Asn Asn Ser Val Ala Leu Arg Thr 340 345 350 Pro Arg Thr Pro Ala Ser Gln Asp Arg Ile Leu Gln Glu Ala Gln Asn 355 360 365 Leu Met Ala Leu Thr Asn Val Asp Thr Pro Leu Lys Gly Gly Leu Asn 370 375 380 Thr Pro Leu His Glu Ser Asp Phe Ser Gly Val Thr Pro Gln Arg Gln 385 390 395 400 Val Val Gln Thr Pro Asn Thr Val Leu Ser Thr Pro Phe Arg Thr Pro 405 410 415 Ser Asn Gly Ala Glu Gly Leu Thr Pro Arg Ser Gly Thr Thr Pro Lys 420 425 430 Pro Val Ile Asn Ser Thr Pro Gly Arg Thr Pro Leu Arg Asp Lys Leu 435 440 445 Asn Ile Asn Pro Glu Asp Gly Met Ala Asp Tyr Ser Asp Pro Ser Tyr 450 455 460 Val Lys Gln Met Glu Arg Glu Ser Arg Glu His Leu Arg Leu Gly Leu 465 470 475 480 Leu Gly Leu Pro Ala Pro Lys Asn Asp Phe Glu Ile Val Leu Pro Glu 485 490 495 Asn Ala Glu Lys Glu Leu Glu Glu Arg Glu Ile Asp Asp Thr Tyr Ile 500 505 510 Glu Asp Ala Ala Asp Val Asp Ala Arg Lys Gln Ala Ile Arg Asp Ala 515 520 525 Glu Arg Val Lys Glu Met Lys Arg Met His Lys Ala Val Gln Lys Asp 530 535 540 Leu Pro Arg Pro Ser Glu Val Asn Glu Thr Ile Leu Arg Pro Leu Asn 545 550 555 560 Val Glu Pro Pro Leu Thr Asp Leu Gln Lys Ser Glu Glu Leu Ile Lys 565 570 575 Lys Glu Met Ile Thr Met Leu His Tyr Asp Leu Leu His His Pro Tyr 580 585 590 Glu Pro Ser Gly Asn Lys Lys Gly Lys Thr Val Gly Phe Gly Thr Asn 595 600 605 Asn Ser Glu His Ile Thr Tyr Leu Glu His Asn Pro Tyr Glu Lys Phe 610 615 620 Ser Lys Glu Glu Leu Lys Lys Ala Gln Asp Val Leu Val Gln Glu Met 625 630 635 640 Glu Val Val Lys Gln Gly Met Ser His Gly Glu Leu Ser Ser Glu Ala 645 650 655 Tyr Asn Gln Val Trp Glu Glu Cys Tyr Ser Gln Val Leu Tyr Leu Pro 660 665 670 Gly Gln Ser Arg Tyr Thr Arg Ala Asn Leu Ala Ser Lys Lys Asp Arg 675 680 685 Ile Glu Ser Leu Glu Lys Arg Leu Glu Ile Asn Arg Gly His Met Thr 690 695 700 Thr Glu Ala Lys Arg Ala Ala Lys Met Glu Lys Lys Met Lys Ile Leu 705 710 715 720 Leu Gly Gly Tyr Gln Ser Arg Ala Met Gly Leu Met Lys Gln Leu Asn 725 730 735 Asp Leu Trp Asp Gln Ile Glu Gln Ala His Leu Glu Leu Arg Thr Phe 740 745 750 Glu Glu Leu Lys Lys His Glu Asp Ser Ala Ile Pro Arg Arg Leu Glu 755 760 765 Cys Leu Lys Glu Asp Val Gln Arg Gln Gln Glu Arg Glu Lys Glu Leu 770 775 780 Gln His Arg Tyr Ala Asp Leu Leu Leu Glu Lys Glu Thr Leu Lys Ser 785 790 795 800 Lys Phe <210> 652 <211> 196 <212> PRT <213> Homo sapiens <400> 652 Met Phe Cys Glu Lys Ala Met Glu Leu Ile Arg Glu Leu His Arg Ala 1 5 10 15 Pro Glu Gly Gln Leu Pro Ala Phe Asn Glu Asp Gly Leu Arg Gln Val 20 25 30 Leu Glu Glu Met Lys Ala Leu Tyr Glu Gln Asn Gln Ser Asp Val Asn 35 40 45 Glu Ala Lys Ser Gly Gly Arg Ser Asp Leu Ile Pro Thr Ile Lys Phe 50 55 60 Arg His Cys Ser Leu Leu Arg Asn Arg Arg Cys Thr Val Ala Tyr Leu 65 70 75 80 Tyr Asp Arg Leu Leu Arg Ile Arg Ala Leu Arg Trp Glu Tyr Gly Ser 85 90 95 Val Leu Pro Asn Ala Leu Arg Phe His Met Ala Ala Glu Glu Met Glu 100 105 110 Trp Phe Asn Asn Tyr Lys Arg Ser Leu Ala Thr Tyr Met Arg Ser Leu 115 120 125 Gly Gly Asp Glu Gly Leu Asp Ile Thr Gln Asp Met Lys Pro Pro Lys 130 135 140 Ser Leu Tyr Ile Glu Val Arg Cys Leu Lys Asp Tyr Gly Glu Phe Glu 145 150 155 160 Val Asp Asp Gly Thr Ser Val Leu Leu Lys Lys Asn Ser Gln His Phe 165 170 175 Leu Pro Arg Trp Lys Cys Glu Gln Leu Ile Arg Gln Gly Val Leu Glu 180 185 190 His Ile Leu Ser 195 <210> 653 <211> 185 <212> PRT <213> Homo sapiens <400> 653 Met Asp Ala Ala Glu Val Glu Phe Leu Ala Glu Lys Glu Leu Val Thr 1 5 10 15 Ile Ile Pro Asn Phe Ser Leu Asp Lys Ile Tyr Leu Ile Gly Gly Asp 20 25 30 Leu Gly Pro Phe Asn Pro Gly Leu Pro Val Glu Val Pro Leu Trp Leu 35 40 45 Ala Ile Asn Leu Lys Gln Arg Gln Lys Cys Arg Leu Leu Pro Pro Glu 50 55 60 Trp Met Asp Val Glu Lys Leu Glu Lys Met Arg Asp His Glu Arg Lys 65 70 75 80 Glu Glu Thr Phe Thr Pro Met Pro Ser Pro Tyr Tyr Met Glu Leu Thr 85 90 95 Lys Leu Leu Leu Asn His Ala Ser Asp Asn Ile Pro Lys Ala Asp Glu 100 105 110 Ile Arg Thr Leu Val Lys Asp Met Trp Asp Thr Arg Ile Ala Lys Leu 115 120 125 Arg Val Ser Ala Asp Ser Phe Val Arg Gln Gln Glu Ala His Ala Lys 130 135 140 Leu Asp Asn Leu Thr Leu Met Glu Ile Asn Thr Ser Gly Thr Phe Leu 145 150 155 160 Thr Gln Ala Leu Asn His Met Tyr Lys Leu Arg Thr Asn Leu Gln Pro 165 170 175 Leu Glu Ser Thr Gln Ser Gln Asp Phe 180 185 <210> 654 <211> 216 <212> PRT <213> Homo sapiens <400> 654 Met Ser Glu Ala Tyr Phe Arg Val Glu Ser Gly Ala Leu Gly Pro Glu 1 5 10 15 Glu Asn Phe Leu Ser Leu Asp Asp Ile Leu Met Ser His Glu Lys Leu 20 25 30 Pro Val Arg Thr Glu Thr Ala Met Pro Arg Leu Gly Ala Phe Phe Leu 35 40 45 Glu Arg Ser Ala Gly Ala Glu Thr Asp Asn Ala Val Pro Gln Gly Ser 50 55 60 Lys Leu Glu Leu Pro Leu Trp Leu Ala Lys Gly Leu Phe Asp Asn Lys 65 70 75 80 Arg Arg Ile Leu Ser Val Glu Leu Pro Lys Ile Tyr Gln Glu Gly Trp 85 90 95 Arg Thr Val Phe Ser Ala Asp Pro Asn Val Val Asp Leu His Lys Met 100 105 110 Gly Pro His Phe Tyr Gly Phe Gly Ser Gln Leu Leu His Phe Asp Ser 115 120 125 Pro Glu Asn Ala Asp Ile Ser Gln Ser Leu Leu Gln Thr Phe Ile Gly 130 135 140 Arg Phe Arg Arg Ile Met Asp Ser Ser Gln Asn Ala Tyr Asn Glu Asp 145 150 155 160 Thr Ser Ala Leu Val Ala Arg Leu Asp Glu Met Glu Arg Gly Leu Phe 165 170 175 Gln Thr Gly Gln Lys Gly Leu Asn Asp Phe Gln Cys Trp Glu Lys Gly 180 185 190 Gln Ala Ser Gln Ile Thr Ala Ser Asn Leu Val Gln Asn Tyr Lys Lys 195 200 205 Arg Lys Phe Thr Asp Met Glu Asp 210 215 <210> 655 <211> 566 <212> PRT <213> Homo sapiens <400> 655 Met Phe Val Ser Asp Phe Arg Lys Glu Phe Tyr Glu Val Val Gln Ser 1 5 10 15 Gln Arg Val Leu Leu Phe Val Ala Ser Asp Val Asp Ala Leu Cys Ala 20 25 30 Cys Lys Ile Leu Gln Ala Leu Phe Gln Cys Asp His Val Gln Tyr Thr 35 40 45 Leu Val Pro Val Ser Gly Trp Gln Glu Leu Glu Thr Ala Phe Leu Glu 50 55 60 His Lys Glu Gln Phe His Tyr Phe Ile Leu Ile Asn Cys Gly Ala Asn 65 70 75 80 Val Asp Leu Leu Asp Ile Leu Gln Pro Asp Glu Asp Thr Ile Phe Phe 85 90 95 Val Cys Asp Thr His Arg Pro Val Asn Val Val Asn Val Tyr Asn Asp 100 105 110 Thr Gln Ile Lys Leu Leu Ile Lys Gln Asp Asp Asp Leu Glu Val Pro 115 120 125 Ala Tyr Glu Asp Ile Phe Arg Asp Glu Glu Glu Asp Glu Glu His Ser 130 135 140 Gly Asn Asp Ser Asp Gly Ser Glu Pro Ser Glu Lys Arg Thr Arg Leu 145 150 155 160 Glu Glu Glu Ile Val Glu Gln Thr Met Arg Arg Arg Gln Arg Arg Glu 165 170 175 Trp Glu Ala Arg Arg Arg Asp Ile Leu Phe Asp Tyr Glu Gln Tyr Glu 180 185 190 Tyr His Gly Thr Ser Ser Ala Met Val Met Phe Glu Leu Ala Trp Met 195 200 205 Leu Ser Lys Asp Leu Asn Asp Met Leu Trp Trp Ala Ile Val Gly Leu 210 215 220 Thr Asp Gln Trp Val Gln Asp Lys Ile Thr Gln Met Lys Tyr Val Thr 225 230 235 240 Asp Val Gly Val Leu Gln Arg His Val Ser Arg His Asn His Arg Asn 245 250 255 Glu Asp Glu Glu Asn Thr Leu Ser Val Asp Cys Thr Arg Ile Ser Phe 260 265 270 Glu Tyr Asp Leu Arg Leu Val Leu Tyr Gln His Trp Ser Leu His Asp 275 280 285 Ser Leu Cys Asn Thr Ser Tyr Thr Ala Ala Arg Phe Lys Leu Trp Ser 290 295 300 Val His Gly Gln Lys Arg Leu Gln Glu Phe Leu Ala Asp Met Gly Leu 305 310 315 320 Pro Leu Lys Gln Val Lys Gln Lys Phe Gln Ala Met Asp Ile Ser Leu 325 330 335 Lys Glu Asn Leu Arg Glu Met Ile Glu Glu Ser Ala Asn Lys Phe Gly 340 345 350 Met Lys Asp Met Arg Val Gln Thr Phe Ser Ile His Phe Gly Phe Lys 355 360 365 His Lys Phe Leu Ala Ser Asp Val Val Phe Ala Thr Met Ser Leu Met 370 375 380 Glu Ser Pro Glu Lys Asp Gly Ser Gly Thr Asp His Phe Ile Gln Ala 385 390 395 400 Leu Asp Ser Leu Ser Arg Ser Asn Leu Asp Lys Leu Tyr His Gly Leu 405 410 415 Glu Leu Ala Lys Lys Gln Leu Arg Ala Thr Gln Gln Thr Ile Ala Ser 420 425 430 Cys Leu Cys Thr Asn Leu Val Ile Ser Gln Gly Pro Phe Leu Tyr Cys 435 440 445 Ser Leu Met Glu Gly Thr Pro Asp Val Met Leu Phe Ser Arg Pro Ala 450 455 460 Ser Leu Ser Leu Leu Ser Lys His Leu Leu Lys Ser Phe Val Cys Ser 465 470 475 480 Thr Lys Asn Arg Arg Cys Lys Leu Leu Pro Leu Val Met Ala Ala Pro 485 490 495 Leu Ser Met Glu His Gly Thr Val Thr Val Val Gly Ile Pro Pro Glu 500 505 510 Thr Asp Ser Ser Asp Arg Lys Asn Phe Phe Gly Arg Ala Phe Glu Lys 515 520 525 Ala Ala Glu Ser Thr Ser Ser Arg Met Leu His Asn His Phe Asp Leu 530 535 540 Ser Val Ile Glu Leu Lys Ala Glu Asp Arg Ser Lys Phe Leu Asp Ala 545 550 555 560 Leu Ile Ser Leu Leu Ser 565 <210> 656 <211> 1462 <212> PRT <213> Homo sapiens <400> 656 Met Ala Pro Val His Gly Asp Asp Ser Leu Ser Asp Ser Gly Ser Phe 1 5 10 15 Val Ser Ser Arg Ala Arg Arg Glu Lys Lys Ser Lys Lys Gly Arg Gln 20 25 30 Glu Ala Leu Glu Arg Leu Lys Lys Ala Lys Ala Gly Glu Lys Tyr Lys 35 40 45 Tyr Glu Val Glu Asp Phe Thr Gly Val Tyr Glu Glu Val Asp Glu Glu 50 55 60 Gln Tyr Ser Lys Leu Val Gln Ala Arg Gln Asp Asp Asp Trp Ile Val 65 70 75 80 Asp Asp Asp Gly Ile Gly Tyr Val Glu Asp Gly Arg Glu Ile Phe Asp 85 90 95 Asp Asp Leu Glu Asp Asp Ala Leu Asp Ala Asp Glu Lys Gly Lys Asp 100 105 110 Gly Lys Ala Arg Asn Lys Asp Lys Arg Asn Val Lys Lys Leu Ala Val 115 120 125 Thr Lys Pro Asn Asn Ile Lys Ser Met Phe Ile Ala Cys Ala Gly Lys 130 135 140 Lys Thr Ala Asp Lys Ala Val Asp Leu Ser Lys Asp Gly Leu Leu Gly 145 150 155 160 Asp Ile Leu Gln Asp Leu Asn Thr Glu Thr Pro Gln Ile Thr Pro Pro 165 170 175 Pro Val Met Ile Leu Lys Lys Lys Arg Ser Ile Gly Ala Ser Pro Asn 180 185 190 Pro Phe Ser Val His Thr Ala Thr Ala Val Pro Ser Gly Lys Ile Ala 195 200 205 Ser Pro Val Ser Arg Lys Glu Pro Pro Leu Thr Pro Val Pro Leu Lys 210 215 220 Arg Ala Glu Phe Ala Gly Asp Asp Val Gln Val Glu Ser Thr Glu Glu 225 230 235 240 Glu Gln Glu Ser Gly Ala Met Glu Phe Glu Asp Gly Asp Phe Asp Glu 245 250 255 Pro Met Glu Val Glu Glu Val Asp Leu Glu Pro Met Ala Ala Lys Ala 260 265 270 Trp Asp Lys Glu Ser Glu Pro Ala Glu Glu Val Lys Gln Glu Ala Asp 275 280 285 Ser Gly Lys Gly Thr Val Ser Tyr Leu Gly Ser Phe Leu Pro Asp Val 290 295 300 Ser Cys Trp Asp Ile Asp Gln Glu Gly Asp Ser Ser Phe Ser Val Gln 305 310 315 320 Glu Val Gln Val Asp Ser Ser His Leu Pro Leu Val Lys Gly Ala Asp 325 330 335 Glu Glu Gln Val Phe His Phe Tyr Trp Leu Asp Ala Tyr Glu Asp Gln 340 345 350 Tyr Asn Gln Pro Gly Val Val Phe Leu Phe Gly Lys Val Trp Ile Glu 355 360 365 Ser Ala Glu Thr His Val Ser Cys Cys Val Met Val Lys Asn Ile Glu 370 375 380 Arg Thr Leu Tyr Phe Leu Pro Arg Glu Met Lys Ile Asp Leu Asn Thr 385 390 395 400 Gly Lys Glu Thr Gly Thr Pro Ile Ser Met Lys Asp Val Tyr Glu Glu 405 410 415 Phe Asp Glu Lys Ile Ala Thr Lys Tyr Lys Ile Met Lys Phe Lys Ser 420 425 430 Lys Pro Val Glu Lys Asn Tyr Ala Phe Glu Ile Pro Asp Val Pro Glu 435 440 445 Lys Ser Glu Tyr Leu Glu Val Lys Tyr Ser Ala Glu Met Pro Gln Leu 450 455 460 Pro Gln Asp Leu Lys Gly Glu Thr Phe Ser His Val Phe Gly Thr Asn 465 470 475 480 Thr Ser Ser Leu Glu Leu Phe Leu Met Asn Arg Lys Ile Lys Gly Pro 485 490 495 Cys Trp Leu Glu Val Lys Lys Ser Thr Ala Leu Asn Gln Pro Val Ser 500 505 510 Trp Cys Lys Val Glu Ala Met Ala Leu Lys Pro Asp Leu Val Asn Val 515 520 525 Ile Lys Asp Val Ser Pro Pro Pro Leu Val Val Met Ala Phe Ser Met 530 535 540 Lys Thr Met Gln Asn Ala Lys Asn His Gln Asn Glu Ile Ile Ala Met 545 550 555 560 Ala Ala Leu Val His His Ser Phe Ala Leu Asp Lys Ala Ala Pro Lys 565 570 575 Pro Pro Phe Gln Ser His Phe Cys Val Val Ser Lys Pro Lys Asp Cys 580 585 590 Ile Phe Pro Tyr Ala Phe Lys Glu Val Ile Glu Lys Lys Asn Val Lys 595 600 605 Val Glu Val Ala Ala Thr Glu Arg Thr Leu Leu Gly Phe Phe Leu Ala 610 615 620 Lys Val His Lys Ile Asp Pro Asp Ile Ile Val Gly His Asn Ile Tyr 625 630 635 640 Gly Phe Glu Leu Glu Val Leu Leu Gln Arg Ile Asn Val Cys Lys Ala 645 650 655 Pro His Trp Ser Lys Ile Gly Arg Leu Lys Arg Ser Asn Met Pro Lys 660 665 670 Leu Gly Gly Arg Ser Gly Phe Gly Glu Arg Asn Ala Thr Cys Gly Arg 675 680 685 Met Ile Cys Asp Val Glu Ile Ser Ala Lys Glu Leu Ile Arg Cys Lys 690 695 700 Ser Tyr His Leu Ser Glu Leu Val Gln Gln Ile Leu Lys Thr Glu Arg 705 710 715 720 Val Val Ile Pro Met Glu Asn Ile Gln Asn Met Tyr Ser Glu Ser Ser 725 730 735 Gln Leu Leu Tyr Leu Leu Glu His Thr Trp Lys Asp Ala Lys Phe Ile 740 745 750 Leu Gln Ile Met Cys Glu Leu Asn Val Leu Pro Leu Ala Leu Gln Ile 755 760 765 Thr Asn Ile Ala Gly Asn Ile Met Ser Arg Thr Leu Met Gly Gly Arg 770 775 780 Ser Glu Arg Asn Glu Phe Leu Leu Leu His Ala Phe Tyr Glu Asn Asn 785 790 795 800 Tyr Ile Val Pro Asp Lys Gln Ile Phe Arg Lys Pro Gln Gln Lys Leu 805 810 815 Gly Asp Glu Asp Glu Glu Ile Asp Gly Asp Thr Asn Lys Tyr Lys Lys 820 825 830 Gly Arg Lys Lys Gly Ala Tyr Ala Gly Gly Leu Val Leu Asp Pro Lys 835 840 845 Val Gly Phe Tyr Asp Lys Phe Ile Leu Leu Leu Asp Phe Asn Ser Leu 850 855 860 Tyr Pro Ser Ile Ile Gln Glu Phe Asn Ile Cys Phe Thr Thr Val Gln 865 870 875 880 Arg Val Ala Ser Glu Ala Gln Lys Val Thr Glu Asp Gly Glu Gln Glu 885 890 895 Gln Ile Pro Glu Leu Pro Asp Pro Ser Leu Glu Met Gly Ile Leu Pro 900 905 910 Arg Glu Ile Arg Lys Leu Val Glu Arg Arg Lys Gln Val Lys Gln Leu 915 920 925 Met Lys Gln Gln Asp Leu Asn Pro Asp Leu Ile Leu Gln Tyr Asp Ile 930 935 940 Arg Gln Lys Ala Leu Lys Leu Thr Ala Asn Ser Met Tyr Gly Cys Leu 945 950 955 960 Gly Phe Ser Tyr Ser Arg Phe Tyr Ala Lys Pro Leu Ala Ala Leu Val 965 970 975 Thr Tyr Lys Gly Arg Glu Ile Leu Met His Thr Lys Glu Met Val Gln 980 985 990 Lys Met Asn Leu Glu Val Ile Tyr Gly Asp Thr Asp Ser Ile Met Ile 995 1000 1005 Asn Thr Asn Ser Thr Asn Leu Glu Glu Val Phe Lys Leu Gly Asn 1010 1015 1020 Lys Val Lys Ser Glu Val Asn Lys Leu Tyr Lys Leu Leu Glu Ile 1025 1030 1035 Asp Ile Asp Gly Val Phe Lys Ser Leu Leu Leu Leu Lys Lys Lys 1040 1045 1050 Lys Tyr Ala Ala Leu Val Val Glu Pro Thr Ser Asp Gly Asn Tyr 1055 1060 1065 Val Thr Lys Gln Glu Leu Lys Gly Leu Asp Ile Val Arg Arg Asp 1070 1075 1080 Trp Cys Asp Leu Ala Lys Asp Thr Gly Asn Phe Val Ile Gly Gln 1085 1090 1095 Ile Leu Ser Asp Gln Ser Arg Asp Thr Ile Val Glu Asn Ile Gln 1100 1105 1110 Lys Arg Leu Ile Glu Ile Gly Glu Asn Val Leu Asn Gly Ser Val 1115 1120 1125 Pro Val Ser Gln Phe Glu Ile Asn Lys Ala Leu Thr Lys Asp Pro 1130 1135 1140 Gln Asp Tyr Pro Asp Lys Lys Ser Leu Pro His Val His Val Ala 1145 1150 1155 Leu Trp Ile Asn Ser Gln Gly Gly Arg Lys Val Lys Ala Gly Asp 1160 1165 1170 Thr Val Ser Tyr Val Ile Cys Gln Asp Gly Ser Asn Leu Thr Ala 1175 1180 1185 Ser Gln Arg Ala Tyr Ala Pro Glu Gln Leu Gln Lys Gln Asp Asn 1190 1195 1200 Leu Thr Ile Asp Thr Gln Tyr Tyr Leu Ala Gln Gln Ile His Pro 1205 1210 1215 Val Val Ala Arg Ile Cys Glu Pro Ile Asp Gly Ile Asp Ala Val 1220 1225 1230 Leu Ile Ala Thr Trp Leu Gly Leu Asp Pro Thr Gln Phe Arg Val 1235 1240 1245 His His Tyr His Lys Asp Glu Glu Asn Asp Ala Leu Leu Gly Gly 1250 1255 1260 Pro Ala Gln Leu Thr Asp Glu Glu Lys Tyr Arg Asp Cys Glu Arg 1265 1270 1275 Phe Lys Cys Pro Cys Pro Thr Cys Gly Thr Glu Asn Ile Tyr Asp 1280 1285 1290 Asn Val Phe Asp Gly Ser Gly Thr Asp Met Glu Pro Ser Leu Tyr 1295 1300 1305 Arg Cys Ser Asn Ile Asp Cys Lys Ala Ser Pro Leu Thr Phe Thr 1310 1315 1320 Val Gln Leu Ser Asn Lys Leu Ile Met Asp Ile Arg Arg Phe Ile 1325 1330 1335 Lys Lys Tyr Tyr Asp Gly Trp Leu Ile Cys Glu Glu Pro Thr Cys 1340 1345 1350 Arg Asn Arg Thr Arg His Leu Pro Leu Gln Phe Ser Arg Thr Gly 1355 1360 1365 Pro Leu Cys Pro Ala Cys Met Lys Ala Thr Leu Gln Pro Glu Tyr 1370 1375 1380 Ser Asp Lys Ser Leu Tyr Thr Gln Leu Cys Phe Tyr Arg Tyr Ile 1385 1390 1395 Phe Asp Ala Glu Cys Ala Leu Glu Lys Leu Thr Thr Asp His Glu 1400 1405 1410 Lys Asp Lys Leu Lys Lys Gln Phe Phe Thr Pro Lys Val Leu Gln 1415 1420 1425 Asp Tyr Arg Lys Leu Lys Asn Thr Ala Glu Gln Phe Leu Ser Arg 1430 1435 1440 Ser Gly Tyr Ser Glu Val Asn Leu Ser Lys Leu Phe Ala Gly Cys 1445 1450 1455 Ala Val Lys Ser 1460 <210> 657 <211> 598 <212> PRT <213> Homo sapiens <400> 657 Met Ser Ala Ser Ala Gln Gln Leu Ala Glu Glu Leu Gln Ile Phe Gly 1 5 10 15 Leu Asp Cys Glu Glu Ala Leu Ile Glu Lys Leu Val Glu Leu Cys Val 20 25 30 Gln Tyr Gly Gln Asn Glu Glu Gly Met Val Gly Glu Leu Ile Ala Phe 35 40 45 Cys Thr Ser Thr His Lys Val Gly Leu Thr Ser Glu Ile Leu Asn Ser 50 55 60 Phe Glu His Glu Phe Leu Ser Lys Arg Leu Ser Lys Ala Arg His Ser 65 70 75 80 Thr Cys Lys Asp Ser Gly His Ala Gly Ala Arg Asp Ile Val Ser Ile 85 90 95 Gln Glu Leu Ile Glu Val Glu Glu Glu Glu Glu Ile Leu Leu Asn Ser 100 105 110 Tyr Thr Thr Pro Ser Lys Gly Ser Gln Lys Arg Ala Ile Ser Thr Pro 115 120 125 Glu Thr Pro Leu Thr Lys Arg Ser Val Ser Thr Arg Ser Pro His Gln 130 135 140 Leu Leu Ser Pro Ser Ser Phe Ser Pro Ser Ala Thr Pro Ser Gln Lys 145 150 155 160 Tyr Asn Ser Arg Ser Asn Arg Gly Glu Val Val Thr Ser Phe Gly Leu 165 170 175 Ala Gln Gly Val Ser Trp Ser Gly Arg Gly Gly Ala Gly Asn Ile Ser 180 185 190 Leu Lys Val Leu Gly Cys Pro Glu Ala Leu Thr Gly Ser Tyr Lys Ser 195 200 205 Met Phe Gln Lys Leu Pro Asp Ile Arg Glu Val Leu Thr Cys Lys Ile 210 215 220 Glu Glu Leu Gly Ser Glu Leu Lys Glu His Tyr Lys Ile Glu Ala Phe 225 230 235 240 Thr Pro Leu Leu Ala Pro Ala Gln Glu Pro Val Thr Leu Leu Gly Gln 245 250 255 Ile Gly Cys Asp Ser Asn Gly Lys Leu Asn Asn Lys Ser Val Ile Leu 260 265 270 Glu Gly Asp Arg Glu His Ser Ser Gly Ala Gln Ile Pro Val Asp Leu 275 280 285 Ser Glu Leu Lys Glu Tyr Ser Leu Phe Pro Gly Gln Val Val Ile Met 290 295 300 Glu Gly Ile Asn Thr Thr Gly Arg Lys Leu Val Ala Thr Lys Leu Tyr 305 310 315 320 Glu Gly Val Pro Leu Pro Phe Tyr Gln Pro Thr Glu Glu Asp Ala Asp 325 330 335 Phe Glu Gln Ser Met Val Leu Val Ala Cys Gly Pro Tyr Thr Thr Ser 340 345 350 Asp Ser Ile Thr Tyr Asp Pro Leu Leu Asp Leu Ile Ala Val Ile Asn 355 360 365 His Asp Arg Pro Asp Val Cys Ile Leu Phe Gly Pro Phe Leu Asp Ala 370 375 380 Lys His Glu Gln Val Glu Asn Cys Leu Leu Thr Ser Pro Phe Glu Asp 385 390 395 400 Ile Phe Lys Gln Cys Leu Arg Thr Ile Ile Glu Gly Thr Arg Ser Ser 405 410 415 Gly Ser His Leu Val Phe Val Pro Ser Leu Arg Asp Val His His Glu 420 425 430 Pro Val Tyr Pro Gln Pro Pro Phe Ser Tyr Ser Asp Leu Ser Arg Glu 435 440 445 Asp Lys Lys Gln Val Gln Phe Val Ser Glu Pro Cys Ser Leu Ser Ile 450 455 460 Asn Gly Val Ile Phe Gly Leu Thr Ser Thr Asp Leu Leu Phe His Leu 465 470 475 480 Gly Ala Glu Glu Ile Ser Ser Ser Ser Gly Thr Ser Asp Arg Phe Ser 485 490 495 Arg Ile Leu Lys His Ile Leu Thr Gln Arg Ser Tyr Tyr Pro Leu Tyr 500 505 510 Pro Pro Gln Glu Asp Met Ala Ile Asp Tyr Glu Ser Phe Tyr Val Tyr 515 520 525 Ala Gln Leu Pro Val Thr Pro Asp Val Leu Ile Ile Pro Ser Glu Leu 530 535 540 Arg Tyr Phe Val Lys Asp Val Leu Gly Cys Val Cys Val Asn Pro Gly 545 550 555 560 Arg Leu Thr Lys Gly Gln Val Gly Gly Thr Phe Ala Arg Leu Tyr Leu 565 570 575 Arg Arg Pro Ala Ala Asp Gly Ala Glu Arg Gln Ser Pro Cys Ile Ala 580 585 590 Val Gln Val Val Arg Ile 595 <210> 658 <211> 509 <212> PRT <213> Homo sapiens <400> 658 Met Glu Phe Ser Gly Arg Lys Trp Arg Lys Leu Arg Leu Ala Gly Asp 1 5 10 15 Gln Arg Asn Ala Ser Tyr Pro His Cys Leu Gln Phe Tyr Leu Gln Pro 20 25 30 Pro Ser Glu Asn Ile Ser Leu Ile Glu Phe Glu Asn Leu Ala Ile Asp 35 40 45 Arg Val Lys Leu Leu Lys Ser Val Glu Asn Leu Gly Val Ser Tyr Val 50 55 60 Lys Gly Thr Glu Gln Tyr Gln Ser Lys Leu Glu Ser Glu Leu Arg Lys 65 70 75 80 Leu Lys Phe Ser Tyr Arg Glu Asn Leu Glu Asp Glu Tyr Glu Pro Arg 85 90 95 Arg Arg Asp His Ile Ser His Phe Ile Leu Arg Leu Ala Tyr Cys Gln 100 105 110 Ser Glu Glu Leu Arg Arg Trp Phe Ile Gln Gln Glu Met Asp Leu Leu 115 120 125 Arg Phe Arg Phe Ser Ile Leu Pro Lys Asp Lys Ile Gln Asp Phe Leu 130 135 140 Lys Asp Ser Gln Leu Gln Phe Glu Ala Ile Ser Asp Glu Glu Lys Thr 145 150 155 160 Leu Arg Glu Gln Glu Ile Val Ala Ser Ser Pro Ser Leu Ser Gly Leu 165 170 175 Lys Leu Gly Phe Glu Ser Ile Tyr Lys Ile Pro Phe Ala Asp Ala Leu 180 185 190 Asp Leu Phe Arg Gly Arg Lys Val Tyr Leu Glu Asp Gly Phe Ala Tyr 195 200 205 Val Pro Leu Lys Asp Ile Val Ala Ile Ile Leu Asn Glu Phe Arg Ala 210 215 220 Lys Leu Ser Lys Ala Leu Ala Leu Thr Ala Arg Ser Leu Pro Ala Val 225 230 235 240 Gln Ser Asp Glu Arg Leu Gln Pro Leu Leu Asn His Leu Ser His Ser 245 250 255 Tyr Thr Gly Gln Asp Tyr Ser Thr Gln Gly Asn Val Gly Lys Ile Ser 260 265 270 Leu Asp Gln Ile Asp Leu Leu Ser Thr Lys Ser Phe Pro Pro Cys Met 275 280 285 Arg Gln Leu His Lys Ala Leu Arg Glu Asn His His Leu Arg His Gly 290 295 300 Gly Arg Met Gln Tyr Gly Leu Phe Leu Lys Gly Ile Gly Leu Thr Leu 305 310 315 320 Glu Gln Ala Leu Gln Phe Trp Lys Gln Glu Phe Ile Lys Gly Lys Met 325 330 335 Asp Pro Asp Lys Phe Asp Lys Gly Tyr Ser Tyr Asn Ile Arg His Ser 340 345 350 Phe Gly Lys Glu Gly Lys Arg Thr Asp Tyr Thr Pro Phe Ser Cys Leu 355 360 365 Lys Ile Ile Leu Ser Asn Pro Pro Ser Gln Gly Asp Tyr His Gly Cys 370 375 380 Pro Phe Arg His Ser Asp Pro Glu Leu Leu Lys Gln Lys Leu Gln Ser 385 390 395 400 Tyr Lys Ile Ser Pro Gly Gly Ile Ser Gln Ile Leu Asp Leu Val Lys 405 410 415 Gly Thr His Tyr Gln Val Ala Cys Gln Lys Tyr Phe Glu Met Ile His 420 425 430 Asn Val Asp Asp Cys Gly Phe Ser Leu Asn His Pro Asn Gln Phe Phe 435 440 445 Cys Glu Ser Gln Arg Ile Leu Asn Gly Gly Lys Asp Ile Lys Lys Glu 450 455 460 Pro Ile Gln Pro Glu Thr Pro Gln Pro Lys Pro Ser Val Gln Lys Thr 465 470 475 480 Lys Asp Ala Ser Ser Ala Leu Ala Ser Leu Asn Ser Ser Leu Glu Met 485 490 495 Asp Met Glu Gly Leu Glu Asp Tyr Phe Ser Glu Asp Ser 500 505 <210> 659 <211> 616 <212> PRT <213> Homo sapiens <400> 659 Met Val Gly Gln Leu Ser Glu Gly Ala Ile Ala Ala Ile Met Gln Lys 1 5 10 15 Gly Asp Thr Asn Ile Lys Pro Ile Leu Gln Val Ile Asn Ile Arg Pro 20 25 30 Ile Thr Thr Gly Asn Ser Pro Pro Arg Tyr Arg Leu Leu Met Ser Asp 35 40 45 Gly Leu Asn Thr Leu Ser Ser Phe Met Leu Ala Thr Gln Leu Asn Pro 50 55 60 Leu Val Glu Glu Glu Gln Leu Ser Ser Asn Cys Val Cys Gln Ile His 65 70 75 80 Arg Phe Ile Val Asn Thr Leu Lys Asp Gly Arg Arg Val Val Ile Leu 85 90 95 Met Glu Leu Glu Val Leu Lys Ser Ala Glu Ala Val Gly Val Lys Ile 100 105 110 Gly Asn Pro Val Pro Tyr Asn Glu Gly Leu Gly Gln Pro Gln Val Ala 115 120 125 Pro Pro Ala Pro Ala Ala Ser Pro Ala Ala Ser Ser Arg Pro Gln Pro 130 135 140 Gln Asn Gly Ser Ser Gly Met Gly Ser Thr Val Ser Lys Ala Tyr Gly 145 150 155 160 Ala Ser Lys Thr Phe Gly Lys Ala Ala Gly Pro Ser Leu Ser His Thr 165 170 175 Ser Gly Gly Thr Gln Ser Lys Val Val Pro Ile Ala Ser Leu Thr Pro 180 185 190 Tyr Gln Ser Lys Trp Thr Ile Cys Ala Arg Val Thr Asn Lys Ser Gln 195 200 205 Ile Arg Thr Trp Ser Asn Ser Arg Gly Glu Gly Lys Leu Phe Ser Leu 210 215 220 Glu Leu Val Asp Glu Ser Gly Glu Ile Arg Ala Thr Ala Phe Asn Glu 225 230 235 240 Gln Val Asp Lys Phe Phe Pro Leu Ile Glu Val Asn Lys Val Tyr Tyr 245 250 255 Phe Ser Lys Gly Thr Leu Lys Ile Ala Asn Lys Gln Phe Thr Ala Val 260 265 270 Lys Asn Asp Tyr Glu Met Thr Phe Asn Asn Glu Thr Ser Val Met Pro 275 280 285 Cys Glu Asp Asp His His Leu Pro Thr Val Gln Phe Asp Phe Thr Gly 290 295 300 Ile Asp Asp Leu Glu Asn Lys Ser Lys Asp Ser Leu Val Asp Ile Ile 305 310 315 320 Gly Ile Cys Lys Ser Tyr Glu Asp Ala Thr Lys Ile Thr Val Arg Ser 325 330 335 Asn Asn Arg Glu Val Ala Lys Arg Asn Ile Tyr Leu Met Asp Thr Ser 340 345 350 Gly Lys Val Val Thr Ala Thr Leu Trp Gly Glu Asp Ala Asp Lys Phe 355 360 365 Asp Gly Ser Arg Gln Pro Val Leu Ala Ile Lys Gly Ala Arg Val Ser 370 375 380 Asp Phe Gly Gly Arg Ser Leu Ser Val Leu Ser Ser Ser Thr Ile Ile 385 390 395 400 Ala Asn Pro Asp Ile Pro Glu Ala Tyr Lys Leu Arg Gly Trp Phe Asp 405 410 415 Ala Glu Gly Gln Ala Leu Asp Gly Val Ser Ile Ser Asp Leu Lys Ser 420 425 430 Gly Gly Val Gly Gly Ser Asn Thr Asn Trp Lys Thr Leu Tyr Glu Val 435 440 445 Lys Ser Glu Asn Leu Gly Gln Gly Asp Lys Pro Asp Tyr Phe Ser Ser 450 455 460 Val Ala Thr Val Val Tyr Leu Arg Lys Glu Asn Cys Met Tyr Gln Ala 465 470 475 480 Cys Pro Thr Gln Asp Cys Asn Lys Lys Val Ile Asp Gln Gln Asn Gly 485 490 495 Leu Tyr Arg Cys Glu Lys Cys Asp Thr Glu Phe Pro Asn Phe Lys Tyr 500 505 510 Arg Met Ile Leu Ser Val Asn Ile Ala Asp Phe Gln Glu Asn Gln Trp 515 520 525 Val Thr Cys Phe Gln Glu Ser Ala Glu Ala Ile Leu Gly Gln Asn Ala 530 535 540 Ala Tyr Leu Gly Glu Leu Lys Asp Lys Asn Glu Gln Ala Phe Glu Glu 545 550 555 560 Val Phe Gln Asn Ala Asn Phe Arg Ser Phe Ile Phe Arg Val Arg Val 565 570 575 Lys Val Glu Thr Tyr Asn Asp Glu Ser Arg Ile Lys Ala Thr Val Met 580 585 590 Asp Val Lys Pro Val Asp Tyr Arg Glu Tyr Gly Arg Arg Leu Val Met 595 600 605 Ser Ile Arg Arg Ser Ala Leu Met 610 615 <210> 660 <211> 270 <212> PRT <213> Homo sapiens <400> 660 Met Trp Asn Ser Gly Phe Glu Ser Tyr Gly Ser Ser Ser Tyr Gly Gly 1 5 10 15 Ala Gly Gly Tyr Thr Gln Ser Pro Gly Gly Phe Gly Ser Pro Ala Pro 20 25 30 Ser Gln Ala Glu Lys Lys Ser Arg Ala Arg Ala Gln His Ile Val Pro 35 40 45 Cys Thr Ile Ser Gln Leu Leu Ser Ala Thr Leu Val Asp Glu Val Phe 50 55 60 Arg Ile Gly Asn Val Glu Ile Ser Gln Val Thr Ile Val Gly Ile Ile 65 70 75 80 Arg His Ala Glu Lys Ala Pro Thr Asn Ile Val Tyr Lys Ile Asp Asp 85 90 95 Met Thr Ala Ala Pro Met Asp Val Arg Gln Trp Val Asp Thr Asp Asp 100 105 110 Thr Ser Ser Glu Asn Thr Val Val Pro Pro Glu Thr Tyr Val Lys Val 115 120 125 Ala Gly His Leu Arg Ser Phe Gln Asn Lys Lys Ser Leu Val Ala Phe 130 135 140 Lys Ile Met Pro Leu Glu Asp Met Asn Glu Phe Thr Thr His Ile Leu 145 150 155 160 Glu Val Ile Asn Ala His Met Val Leu Ser Lys Ala Asn Ser Gln Pro 165 170 175 Ser Ala Gly Arg Ala Pro Ile Ser Asn Pro Gly Met Ser Glu Ala Gly 180 185 190 Asn Phe Gly Gly Asn Ser Phe Met Pro Ala Asn Gly Leu Thr Val Ala 195 200 205 Gln Asn Gln Val Leu Asn Leu Ile Lys Ala Cys Pro Arg Pro Glu Gly 210 215 220 Leu Asn Phe Gln Asp Leu Lys Asn Gln Leu Lys His Met Ser Val Ser 225 230 235 240 Ser Ile Lys Gln Ala Val Asp Phe Leu Ser Asn Glu Gly His Ile Tyr 245 250 255 Ser Thr Val Asp Asp Asp His Phe Lys Ser Thr Asp Ala Glu 260 265 270 <210> 661 <211> 261 <212> PRT <213> Homo sapiens <400> 661 Met Phe Glu Ala Arg Leu Val Gln Gly Ser Ile Leu Lys Lys Val Leu 1 5 10 15 Glu Ala Leu Lys Asp Leu Ile Asn Glu Ala Cys Trp Asp Ile Ser Ser 20 25 30 Ser Gly Val Asn Leu Gln Ser Met Asp Ser Ser His Val Ser Leu Val 35 40 45 Gln Leu Thr Leu Arg Ser Glu Gly Phe Asp Thr Tyr Arg Cys Asp Arg 50 55 60 Asn Leu Ala Met Gly Val Asn Leu Thr Ser Met Ser Lys Ile Leu Lys 65 70 75 80 Cys Ala Gly Asn Glu Asp Ile Ile Thr Leu Arg Ala Glu Asp Asn Ala 85 90 95 Asp Thr Leu Ala Leu Val Phe Glu Ala Pro Asn Gln Glu Lys Val Ser 100 105 110 Asp Tyr Glu Met Lys Leu Met Asp Leu Asp Val Glu Gln Leu Gly Ile 115 120 125 Pro Glu Gln Glu Tyr Ser Cys Val Val Lys Met Pro Ser Gly Glu Phe 130 135 140 Ala Arg Ile Cys Arg Asp Leu Ser His Ile Gly Asp Ala Val Val Ile 145 150 155 160 Ser Cys Ala Lys Asp Gly Val Lys Phe Ser Ala Ser Gly Glu Leu Gly 165 170 175 Asn Gly Asn Ile Lys Leu Ser Gln Thr Ser Asn Val Asp Lys Glu Glu 180 185 190 Glu Ala Val Thr Ile Glu Met Asn Glu Pro Val Gln Leu Thr Phe Ala 195 200 205 Leu Arg Tyr Leu Asn Phe Phe Thr Lys Ala Thr Pro Leu Ser Ser Thr 210 215 220 Val Thr Leu Ser Met Ser Ala Asp Val Pro Leu Val Val Glu Tyr Lys 225 230 235 240 Ile Ala Asp Met Gly His Leu Lys Tyr Tyr Leu Ala Pro Lys Ile Glu 245 250 255 Asp Glu Glu Gly Ser 260 <210> 662 <211> 1844 <212> PRT <213> Homo sapiens <400> 662 Met Val Gly Val Leu Ala Met Ala Ala Ala Ala Ala Pro Pro Pro Val 1 5 10 15 Lys Asp Cys Glu Ile Glu Pro Cys Lys Lys Arg Lys Lys Asp Asp Asp 20 25 30 Thr Ser Thr Cys Lys Thr Ile Thr Lys Tyr Leu Ser Pro Leu Gly Lys 35 40 45 Thr Arg Asp Arg Val Phe Ala Pro Pro Lys Pro Ser Asn Ile Leu Asp 50 55 60 Tyr Phe Arg Lys Thr Ser Pro Thr Asn Glu Lys Thr Gln Leu Gly Lys 65 70 75 80 Glu Cys Lys Ile Lys Ser Pro Glu Ser Val Pro Val Asp Ser Asn Lys 85 90 95 Asp Cys Thr Thr Pro Leu Glu Met Phe Ser Asn Val Glu Phe Lys Lys 100 105 110 Lys Arg Lys Arg Val Asn Leu Ser His Gln Leu Asn Asn Ile Lys Thr 115 120 125 Glu Asn Glu Ala Pro Ile Glu Ile Ser Ser Asp Asp Ser Lys Glu Asp 130 135 140 Tyr Ser Leu Asn Asn Asp Phe Val Glu Ser Ser Thr Ser Val Leu Arg 145 150 155 160 Tyr Lys Lys Gln Val Glu Val Leu Ala Glu Asn Ile Gln Asp Thr Lys 165 170 175 Ser Gln Pro Asn Thr Met Thr Ser Leu Gln Asn Ser Lys Lys Val Asn 180 185 190 Pro Lys Gln Gly Thr Thr Lys Asn Asp Phe Lys Lys Leu Arg Lys Arg 195 200 205 Lys Cys Arg Asp Val Val Asp Leu Ser Glu Ser Leu Pro Leu Ala Glu 210 215 220 Glu Leu Asn Leu Leu Lys Lys Asp Gly Lys Asp Thr Lys Gln Met Glu 225 230 235 240 Asn Thr Thr Ser His Ala Asn Ser Arg Asp Asn Val Thr Glu Ala Ala 245 250 255 Gln Leu Asn Asp Ser Ile Ile Thr Val Ser Tyr Glu Glu Phe Leu Lys 260 265 270 Ser His Lys Glu Asn Lys Val Glu Glu Ile Pro Asp Ser Thr Met Ser 275 280 285 Ile Cys Val Pro Ser Glu Thr Val Asp Glu Ile Val Lys Ser Gly Tyr 290 295 300 Ile Ser Glu Ser Glu Asn Ser Glu Ile Ser Gln Gln Val Arg Phe Lys 305 310 315 320 Thr Val Thr Val Leu Ala Gln Val His Pro Ile Pro Pro Lys Lys Thr 325 330 335 Gly Lys Ile Pro Arg Ile Phe Leu Lys Gln Lys Gln Phe Glu Met Glu 340 345 350 Asn Ser Leu Ser Asp Pro Glu Asn Glu Gln Thr Val Gln Lys Arg Lys 355 360 365 Ser Asn Val Val Ile Gln Glu Glu Glu Leu Glu Leu Ala Val Leu Glu 370 375 380 Ala Gly Ser Ser Glu Ala Val Lys Pro Lys Cys Thr Leu Glu Glu Arg 385 390 395 400 Gln Gln Phe Met Lys Ala Phe Arg Gln Pro Ala Ser Asp Ala Leu Lys 405 410 415 Asn Gly Val Lys Lys Ser Ser Asp Lys Gln Lys Asp Leu Asn Glu Lys 420 425 430 Cys Leu Tyr Glu Val Gly Arg Asp Asp Asn Ser Lys Lys Ile Met Glu 435 440 445 Asn Ser Gly Ile Gln Met Val Ser Lys Asn Gly Asn Leu Gln Leu His 450 455 460 Thr Asp Lys Gly Ser Phe Leu Lys Glu Lys Asn Lys Lys Leu Lys Lys 465 470 475 480 Lys Asn Lys Lys Thr Leu Asp Thr Gly Ala Ile Pro Gly Lys Asn Arg 485 490 495 Glu Gly Asn Thr Gln Lys Lys Glu Thr Thr Phe Phe Leu Lys Glu Lys 500 505 510 Gln Tyr Gln Asn Arg Met Ser Leu Arg Gln Arg Lys Thr Glu Phe Phe 515 520 525 Lys Ser Ser Thr Leu Phe Asn Asn Glu Ser Leu Val Tyr Glu Asp Ile 530 535 540 Ala Asn Asp Asp Leu Leu Lys Val Ser Ser Leu Cys Asn Asn Asn Lys 545 550 555 560 Leu Ser Arg Lys Thr Ser Ile Pro Val Lys Asp Ile Lys Leu Thr Gln 565 570 575 Ser Lys Ala Glu Ser Glu Ala Ser Leu Leu Asn Val Ser Thr Pro Lys 580 585 590 Ser Thr Arg Arg Ser Gly Arg Ile Ser Ser Thr Pro Thr Thr Glu Thr 595 600 605 Ile Arg Gly Ile Asp Ser Asp Asp Val Gln Asp Asn Ser Gln Leu Lys 610 615 620 Ala Ser Thr Gln Lys Ala Ala Asn Leu Ser Glu Lys His Ser Leu Tyr 625 630 635 640 Thr Ala Glu Leu Ile Thr Val Pro Phe Asp Ser Glu Ser Pro Ile Arg 645 650 655 Met Lys Phe Thr Arg Ile Ser Thr Pro Lys Lys Ser Lys Lys Lys Ser 660 665 670 Asn Lys Arg Ser Glu Lys Ser Glu Ala Thr Asp Gly Gly Phe Thr Ser 675 680 685 Gln Ile Arg Lys Ala Ser Asn Thr Ser Lys Asn Ile Ser Lys Ala Lys 690 695 700 Gln Leu Ile Glu Lys Ala Lys Ala Leu His Ile Ser Arg Ser Lys Val 705 710 715 720 Thr Glu Glu Ile Ala Ile Pro Leu Arg Arg Ser Ser Arg His Gln Thr 725 730 735 Leu Pro Glu Arg Lys Lys Leu Ser Glu Thr Glu Asp Ser Val Ile Ile 740 745 750 Ile Asp Ser Ser Pro Thr Ala Leu Lys His Pro Glu Lys Asn Gln Lys 755 760 765 Lys Leu Gln Cys Leu Asn Asp Val Leu Gly Lys Lys Leu Asn Thr Ser 770 775 780 Thr Lys Asn Val Pro Gly Lys Met Lys Val Ala Pro Leu Phe Leu Val 785 790 795 800 Arg Lys Ala Gln Lys Ala Ala Asp Pro Val Pro Ser Phe Asp Glu Ser 805 810 815 Ser Gln Asp Thr Ser Glu Lys Ser Gln Asp Cys Asp Val Gln Cys Lys 820 825 830 Ala Lys Arg Asp Phe Leu Met Ser Gly Leu Pro Asp Leu Leu Lys Arg 835 840 845 Gln Ile Ala Lys Lys Ala Ala Ala Leu Asp Val Tyr Asn Ala Val Ser 850 855 860 Thr Ser Phe Gln Arg Val Val His Val Gln Gln Lys Asp Asp Gly Cys 865 870 875 880 Cys Leu Trp His Leu Lys Pro Pro Ser Cys Pro Leu Leu Thr Lys Phe 885 890 895 Lys Glu Leu Asn Thr Lys Val Ile Asp Leu Ser Lys Cys Gly Ile Ala 900 905 910 Leu Gly Glu Phe Ser Thr Leu Asn Ser Lys Leu Lys Ser Gly Asn Ser 915 920 925 Ala Ala Val Phe Met Arg Thr Arg Lys Glu Phe Thr Glu Glu Val Arg 930 935 940 Asn Leu Leu Leu Glu Glu Ile Arg Trp Ser Asn Pro Glu Phe Ser Leu 945 950 955 960 Lys Lys Tyr Phe Pro Leu Leu Leu Lys Lys Gln Ile Glu His Gln Val 965 970 975 Leu Ser Ser Glu Cys His Ser Lys Gln Glu Leu Glu Ala Asp Val Ser 980 985 990 His Lys Glu Thr Lys Arg Lys Leu Val Glu Ala Glu Asn Ser Lys Ser 995 1000 1005 Lys Arg Lys Lys Pro Asn Glu Tyr Ser Lys Asn Leu Glu Lys Thr 1010 1015 1020 Asn Arg Lys Ser Glu Glu Leu Ser Lys Arg Asn Asn Ser Ser Gly 1025 1030 1035 Ile Lys Leu Asp Ser Ser Lys Asp Ser Gly Thr Glu Asp Met Leu 1040 1045 1050 Trp Thr Glu Lys Tyr Gln Pro Gln Thr Ala Ser Glu Leu Ile Gly 1055 1060 1065 Asn Glu Leu Ala Ile Lys Lys Leu His Ser Trp Leu Lys Asp Trp 1070 1075 1080 Lys Arg Arg Ala Glu Leu Glu Glu Arg Gln Asn Leu Lys Gly Lys 1085 1090 1095 Arg Asp Glu Lys His Glu Asp Phe Ser Gly Gly Ile Asp Phe Lys 1100 1105 1110 Gly Ser Ser Asp Asp Glu Glu Glu Ser Arg Leu Cys Asn Thr Val 1115 1120 1125 Leu Ile Thr Gly Pro Thr Gly Val Gly Lys Thr Ala Ala Val Tyr 1130 1135 1140 Ala Cys Ala Gln Glu Leu Gly Phe Lys Ile Phe Glu Val Asn Ala 1145 1150 1155 Ser Ser Gln Arg Ser Gly Arg Gln Ile Leu Ser Gln Leu Lys Glu 1160 1165 1170 Ala Thr Gln Ser His Gln Val Asp Lys Gln Gly Val Asn Ser Gln 1175 1180 1185 Lys Pro Cys Phe Phe Asn Ser Tyr Tyr Ile Gly Lys Ser Pro Lys 1190 1195 1200 Lys Ile Ser Ser Pro Lys Lys Val Val Thr Ser Pro Arg Lys Val 1205 1210 1215 Pro Pro Pro Ser Pro Lys Ser Ser Gly Pro Lys Arg Ala Leu Pro 1220 1225 1230 Pro Lys Thr Leu Ala Asn Tyr Phe Lys Val Ser Pro Lys Pro Lys 1235 1240 1245 Asn Asn Glu Glu Ile Gly Met Leu Leu Glu Asn Asn Lys Gly Ile 1250 1255 1260 Lys Asn Ser Phe Glu Gln Lys Gln Ile Thr Gln Thr Lys Ser Thr 1265 1270 1275 Asn Ala Thr Asn Ser Asn Val Lys Asp Val Gly Ala Glu Glu Pro 1280 1285 1290 Ser Arg Lys Asn Ala Thr Ser Leu Ile Leu Phe Glu Glu Val Asp 1295 1300 1305 Val Ile Phe Asp Glu Asp Ala Gly Phe Leu Asn Ala Ile Lys Thr 1310 1315 1320 Phe Met Ala Thr Thr Lys Arg Pro Val Ile Leu Thr Thr Ser Asp 1325 1330 1335 Pro Thr Phe Ser Leu Met Phe Asp Gly Cys Phe Glu Glu Ile Lys 1340 1345 1350 Phe Ser Thr Pro Ser Leu Leu Asn Val Ala Ser Tyr Leu Gln Met 1355 1360 1365 Ile Cys Leu Thr Glu Asn Phe Arg Thr Asp Val Lys Asp Phe Val 1370 1375 1380 Thr Leu Leu Thr Ala Asn Thr Cys Asp Ile Arg Lys Ser Ile Leu 1385 1390 1395 Tyr Leu Gln Phe Trp Ile Arg Ser Gly Gly Gly Val Leu Glu Glu 1400 1405 1410 Arg Pro Leu Thr Leu Tyr Arg Gly Asn Ser Arg Asn Val Gln Leu 1415 1420 1425 Val Cys Ser Glu His Gly Leu Asp Asn Lys Ile Tyr Pro Lys Asn 1430 1435 1440 Thr Lys Lys Lys Arg Val Asp Leu Pro Lys Cys Asp Ser Gly Cys 1445 1450 1455 Ala Glu Thr Leu Phe Gly Leu Lys Asn Ile Phe Ser Pro Ser Glu 1460 1465 1470 Asp Leu Phe Ser Phe Leu Lys His Lys Ile Thr Met Lys Glu Glu 1475 1480 1485 Trp His Lys Phe Ile Gln Leu Leu Thr Glu Phe Gln Met Arg Asn 1490 1495 1500 Val Asp Phe Leu Tyr Ser Asn Leu Glu Phe Ile Leu Pro Leu Pro 1505 1510 1515 Val Asp Thr Ile Pro Glu Thr Lys Asn Phe Cys Gly Pro Ser Val 1520 1525 1530 Thr Val Asp Ala Ser Ala Ala Thr Lys Ser Met Asn Cys Leu Ala 1535 1540 1545 Arg Lys His Ser Glu Arg Glu Gln Pro Leu Lys Lys Ser Gln Lys 1550 1555 1560 Lys Lys Gln Lys Lys Thr Leu Val Ile Leu Asp Asp Ser Asp Leu 1565 1570 1575 Phe Asp Thr Asp Leu Asp Phe Pro Asp Gln Ser Ile Ser Leu Ser 1580 1585 1590 Ser Val Ser Ser Ser Ser Asn Ala Glu Glu Ser Lys Thr Gly Asp 1595 1600 1605 Glu Glu Ser Lys Ala Arg Asp Lys Gly Asn Asn Pro Glu Thr Lys 1610 1615 1620 Lys Ser Ile Pro Cys Pro Pro Lys Thr Thr Ala Gly Lys Lys Cys 1625 1630 1635 Ser Ala Leu Val Ser His Cys Leu Asn Ser Leu Ser Glu Phe Met 1640 1645 1650 Asp Asn Met Ser Phe Leu Asp Ala Leu Leu Thr Asp Val Arg Glu 1655 1660 1665 Gln Asn Lys Tyr Gly Arg Asn Asp Phe Ser Trp Thr Asn Gly Lys 1670 1675 1680 Val Thr Ser Gly Leu Cys Asp Glu Phe Ser Leu Glu Ser Asn Asp 1685 1690 1695 Gly Trp Thr Ser Gln Ser Ser Gly Glu Leu Lys Ala Ala Ala Glu 1700 1705 1710 Ala Leu Ser Phe Thr Lys Cys Ser Ser Ala Ile Ser Lys Ala Leu 1715 1720 1725 Glu Thr Leu Asn Ser Cys Lys Lys Leu Gly Arg Asp Pro Thr Asn 1730 1735 1740 Asp Leu Thr Phe Tyr Val Ser Gln Lys Arg Asn Asn Val Tyr Phe 1745 1750 1755 Ser Gln Ser Ala Ala Asn Leu Asp Asn Ala Trp Lys Arg Ile Ser 1760 1765 1770 Val Ile Lys Ser Val Phe Ser Ser Arg Ser Leu Leu Tyr Val Gly 1775 1780 1785 Asn Arg Gln Ala Ser Ile Ile Glu Tyr Leu Pro Thr Leu Arg Asn 1790 1795 1800 Ile Cys Lys Thr Glu Lys Leu Lys Glu Gln Gly Lys Ser Lys Arg 1805 1810 1815 Arg Phe Leu His Tyr Phe Glu Gly Ile His Leu Asp Ile Pro Lys 1820 1825 1830 Glu Thr Val Asn Thr Leu Ala Ala Asp Phe Pro 1835 1840 <210> 663 <211> 380 <212> PRT <213> Homo sapiens <400> 663 Met Gly Ile Gln Gly Leu Ala Lys Leu Ile Ala Asp Val Ala Pro Ser 1 5 10 15 Ala Ile Arg Glu Asn Asp Ile Lys Ser Tyr Phe Gly Arg Lys Val Ala 20 25 30 Ile Asp Ala Ser Met Ser Ile Tyr Gln Phe Leu Ile Ala Val Arg Gln 35 40 45 Gly Gly Asp Val Leu Gln Asn Glu Glu Gly Glu Thr Thr Ser His Leu 50 55 60 Met Gly Met Phe Tyr Arg Thr Ile Arg Met Met Glu Asn Gly Ile Lys 65 70 75 80 Pro Val Tyr Val Phe Asp Gly Lys Pro Pro Gln Leu Lys Ser Gly Glu 85 90 95 Leu Ala Lys Arg Ser Glu Arg Arg Ala Glu Ala Glu Lys Gln Leu Gln 100 105 110 Gln Ala Gln Ala Ala Gly Ala Glu Gln Glu Val Glu Lys Phe Thr Lys 115 120 125 Arg Leu Val Lys Val Thr Lys Gln His Asn Asp Glu Cys Lys His Leu 130 135 140 Leu Ser Leu Met Gly Ile Pro Tyr Leu Asp Ala Pro Ser Glu Ala Glu 145 150 155 160 Ala Ser Cys Ala Ala Leu Val Lys Ala Gly Lys Val Tyr Ala Ala Ala 165 170 175 Thr Glu Asp Met Asp Cys Leu Thr Phe Gly Ser Pro Val Leu Met Arg 180 185 190 His Leu Thr Ala Ser Glu Ala Lys Lys Leu Pro Ile Gln Glu Phe His 195 200 205 Leu Ser Arg Ile Leu Gln Glu Leu Gly Leu Asn Gln Glu Gln Phe Val 210 215 220 Asp Leu Cys Ile Leu Leu Gly Ser Asp Tyr Cys Glu Ser Ile Arg Gly 225 230 235 240 Ile Gly Pro Lys Arg Ala Val Asp Leu Ile Gln Lys His Lys Ser Ile 245 250 255 Glu Glu Ile Val Arg Arg Leu Asp Pro Asn Lys Tyr Pro Val Pro Glu 260 265 270 Asn Trp Leu His Lys Glu Ala His Gln Leu Phe Leu Glu Pro Glu Val 275 280 285 Leu Asp Pro Glu Ser Val Glu Leu Lys Trp Ser Glu Pro Asn Glu Glu 290 295 300 Glu Leu Ile Lys Phe Met Cys Gly Glu Lys Gln Phe Ser Glu Glu Arg 305 310 315 320 Ile Arg Ser Gly Val Lys Arg Leu Ser Lys Ser Arg Gln Gly Ser Thr 325 330 335 Gln Gly Arg Leu Asp Asp Phe Phe Lys Val Thr Gly Ser Leu Ser Ser 340 345 350 Ala Lys Arg Lys Glu Pro Glu Pro Lys Gly Ser Thr Lys Lys Lys Ala 355 360 365 Lys Thr Gly Ala Ala Gly Lys Phe Lys Arg Gly Lys 370 375 380 <210> 664 <211> 1092 <212> PRT <213> Homo sapiens <400> 664 Met Gly Gln Trp Ser Gly Phe Gln Ile Asp Asn Phe Leu Cys Tyr Pro 1 5 10 15 Arg Phe Arg Cys Leu Phe Cys Leu Gln Phe Ala Ile Pro Ala Ser Arg 20 25 30 Met Glu Gln Leu Asn Glu Leu Glu Leu Leu Met Glu Lys Ser Phe Trp 35 40 45 Glu Glu Ala Glu Leu Pro Ala Glu Leu Phe Gln Lys Lys Val Val Ala 50 55 60 Ser Phe Pro Arg Thr Val Leu Ser Thr Gly Met Asp Asn Arg Tyr Leu 65 70 75 80 Val Leu Ala Val Asn Thr Val Gln Asn Lys Glu Gly Asn Cys Glu Lys 85 90 95 Arg Leu Val Ile Thr Ala Ser Gln Ser Leu Glu Asn Lys Glu Leu Cys 100 105 110 Ile Leu Arg Asn Asp Trp Cys Ser Val Pro Val Glu Pro Gly Asp Ile 115 120 125 Ile His Leu Glu Gly Asp Cys Thr Ser Asp Thr Trp Ile Ile Asp Lys 130 135 140 Asp Phe Gly Tyr Leu Ile Leu Tyr Pro Asp Met Leu Ile Ser Gly Thr 145 150 155 160 Ser Ile Ala Ser Ser Ile Arg Cys Met Arg Arg Ala Val Leu Ser Glu 165 170 175 Thr Phe Arg Ser Ser Asp Pro Ala Thr Arg Gln Met Leu Ile Gly Thr 180 185 190 Val Leu His Glu Val Phe Gln Lys Ala Ile Asn Asn Ser Phe Ala Pro 195 200 205 Glu Lys Leu Gln Glu Leu Ala Phe Gln Thr Ile Gln Glu Ile Arg His 210 215 220 Leu Lys Glu Met Tyr Arg Leu Asn Leu Ser Gln Asp Glu Ile Lys Gln 225 230 235 240 Glu Val Glu Asp Tyr Leu Pro Ser Phe Cys Lys Trp Ala Gly Asp Phe 245 250 255 Met His Lys Asn Thr Ser Thr Asp Phe Pro Gln Met Gln Leu Ser Leu 260 265 270 Pro Ser Asp Asn Ser Lys Asp Asn Ser Thr Cys Asn Ile Glu Val Val 275 280 285 Lys Pro Met Asp Ile Glu Glu Ser Ile Trp Ser Pro Arg Phe Gly Leu 290 295 300 Lys Gly Lys Ile Asp Val Thr Val Gly Val Lys Ile His Arg Gly Tyr 305 310 315 320 Lys Thr Lys Tyr Lys Ile Met Pro Leu Glu Leu Lys Thr Gly Lys Glu 325 330 335 Ser Asn Ser Ile Glu His Arg Ser Gln Val Val Leu Tyr Thr Leu Leu 340 345 350 Ser Gln Glu Arg Arg Ala Asp Pro Glu Ala Gly Leu Leu Leu Tyr Leu 355 360 365 Lys Thr Gly Gln Met Tyr Pro Val Pro Ala Asn His Leu Asp Lys Arg 370 375 380 Glu Leu Leu Lys Leu Arg Asn Gln Met Ala Phe Ser Leu Phe His Arg 385 390 395 400 Ile Ser Lys Ser Ala Thr Arg Gln Lys Thr Gln Leu Ala Ser Leu Pro 405 410 415 Gln Ile Ile Glu Glu Glu Lys Thr Cys Lys Tyr Cys Ser Gln Ile Gly 420 425 430 Asn Cys Ala Leu Tyr Ser Arg Ala Val Glu Gln Gln Met Asp Cys Ser 435 440 445 Ser Val Pro Ile Val Met Leu Pro Lys Ile Glu Glu Glu Thr Gln His 450 455 460 Leu Lys Gln Thr His Leu Glu Tyr Phe Ser Leu Trp Cys Leu Met Leu 465 470 475 480 Thr Leu Glu Ser Gln Ser Lys Asp Asn Lys Lys Asn His Gln Asn Ile 485 490 495 Trp Leu Met Pro Ala Ser Glu Met Glu Lys Ser Gly Ser Cys Ile Gly 500 505 510 Asn Leu Ile Arg Met Glu His Val Lys Ile Val Cys Asp Gly Gln Tyr 515 520 525 Leu His Asn Phe Gln Cys Lys His Gly Ala Ile Pro Val Thr Asn Leu 530 535 540 Met Ala Gly Asp Arg Val Ile Val Ser Gly Glu Glu Arg Ser Leu Phe 545 550 555 560 Ala Leu Ser Arg Gly Tyr Val Lys Glu Ile Asn Met Thr Thr Val Thr 565 570 575 Cys Leu Leu Asp Arg Asn Leu Ser Val Leu Pro Glu Ser Thr Leu Phe 580 585 590 Arg Leu Asp Gln Glu Glu Lys Asn Cys Asp Ile Asp Thr Pro Leu Gly 595 600 605 Asn Leu Ser Lys Leu Met Glu Asn Thr Phe Val Ser Lys Lys Leu Arg 610 615 620 Asp Leu Ile Ile Asp Phe Arg Glu Pro Gln Phe Ile Ser Tyr Leu Ser 625 630 635 640 Ser Val Leu Pro His Asp Ala Lys Asp Thr Val Ala Cys Ile Leu Lys 645 650 655 Gly Leu Asn Lys Pro Gln Arg Gln Ala Met Lys Lys Val Leu Leu Ser 660 665 670 Lys Asp Tyr Thr Leu Ile Val Gly Met Pro Gly Thr Gly Lys Thr Thr 675 680 685 Thr Ile Cys Thr Leu Val Arg Ile Leu Tyr Ala Cys Gly Phe Ser Val 690 695 700 Leu Leu Thr Ser Tyr Thr His Ser Ala Val Asp Asn Ile Leu Leu Lys 705 710 715 720 Leu Ala Lys Phe Lys Ile Gly Phe Leu Arg Leu Gly Gln Ile Gln Lys 725 730 735 Val His Pro Ala Ile Gln Gln Phe Thr Glu Gln Glu Ile Cys Arg Ser 740 745 750 Lys Ser Ile Lys Ser Leu Ala Leu Leu Glu Glu Leu Tyr Asn Ser Gln 755 760 765 Leu Ile Val Ala Thr Thr Cys Met Gly Ile Asn His Pro Ile Phe Ser 770 775 780 Arg Lys Ile Phe Asp Phe Cys Ile Val Asp Glu Ala Ser Gln Ile Ser 785 790 795 800 Gln Pro Ile Cys Leu Gly Pro Leu Phe Phe Ser Arg Arg Phe Val Leu 805 810 815 Val Gly Asp His Gln Gln Leu Pro Pro Leu Val Leu Asn Arg Glu Ala 820 825 830 Arg Ala Leu Gly Met Ser Glu Ser Leu Phe Lys Arg Leu Glu Gln Asn 835 840 845 Lys Ser Ala Val Val Gln Leu Thr Val Gln Tyr Arg Met Asn Ser Lys 850 855 860 Ile Met Ser Leu Ser Asn Lys Leu Thr Tyr Glu Gly Lys Leu Glu Cys 865 870 875 880 Gly Ser Asp Lys Val Ala Asn Ala Val Ile Asn Leu Arg His Phe Lys 885 890 895 Asp Val Lys Leu Glu Leu Glu Phe Tyr Ala Asp Tyr Ser Asp Asn Pro 900 905 910 Trp Leu Met Gly Val Phe Glu Pro Asn Asn Pro Val Cys Phe Leu Asn 915 920 925 Thr Asp Lys Val Pro Ala Pro Glu Gln Val Glu Lys Gly Gly Val Ser 930 935 940 Asn Val Thr Glu Ala Lys Leu Ile Val Phe Leu Thr Ser Ile Phe Val 945 950 955 960 Lys Ala Gly Cys Ser Pro Ser Asp Ile Gly Ile Ile Ala Pro Tyr Arg 965 970 975 Gln Gln Leu Lys Ile Ile Asn Asp Leu Leu Ala Arg Ser Ile Gly Met 980 985 990 Val Glu Val Asn Thr Val Asp Lys Tyr Gln Gly Arg Asp Lys Ser Ile 995 1000 1005 Val Leu Val Ser Phe Val Arg Ser Asn Lys Asp Gly Thr Val Gly 1010 1015 1020 Glu Leu Leu Lys Asp Trp Arg Arg Leu Asn Val Ala Ile Thr Arg 1025 1030 1035 Ala Lys His Lys Leu Ile Leu Leu Gly Cys Val Pro Ser Leu Asn 1040 1045 1050 Cys Tyr Pro Pro Leu Glu Lys Leu Leu Asn His Leu Asn Ser Glu 1055 1060 1065 Lys Leu Ile Ile Asp Leu Pro Ser Arg Glu His Glu Ser Leu Cys 1070 1075 1080 His Ile Leu Gly Asp Phe Gln Arg Glu 1085 1090 <210> 665 <211> 919 <212> PRT <213> Homo sapiens <400> 665 Met Gln Arg Ser Ile Met Ser Phe Phe His Pro Lys Lys Glu Gly Lys 1 5 10 15 Ala Lys Lys Pro Glu Lys Glu Ala Ser Asn Ser Ser Arg Glu Thr Glu 20 25 30 Pro Pro Pro Lys Ala Ala Leu Lys Glu Trp Asn Gly Val Val Ser Glu 35 40 45 Ser Asp Ser Pro Val Lys Arg Pro Gly Arg Lys Ala Ala Arg Val Leu 50 55 60 Gly Ser Glu Gly Glu Glu Glu Asp Glu Ala Leu Ser Pro Ala Lys Gly 65 70 75 80 Gln Lys Pro Ala Leu Asp Cys Ser Gln Val Ser Pro Pro Arg Pro Ala 85 90 95 Thr Ser Pro Glu Asn Asn Ala Ser Leu Ser Asp Thr Ser Pro Met Asp 100 105 110 Ser Ser Pro Ser Gly Ile Pro Lys Arg Arg Thr Ala Arg Lys Gln Leu 115 120 125 Pro Lys Arg Thr Ile Gln Glu Val Leu Glu Glu Gln Ser Glu Asp Glu 130 135 140 Asp Arg Glu Ala Lys Arg Lys Lys Glu Glu Glu Glu Glu Glu Thr Pro 145 150 155 160 Lys Glu Ser Leu Thr Glu Ala Glu Val Ala Thr Glu Lys Glu Gly Glu 165 170 175 Asp Gly Asp Gln Pro Thr Thr Pro Pro Lys Pro Leu Lys Thr Ser Lys 180 185 190 Ala Glu Thr Pro Thr Glu Ser Val Ser Glu Pro Glu Val Ala Thr Lys 195 200 205 Gln Glu Leu Gln Glu Glu Glu Glu Gln Thr Lys Pro Pro Arg Arg Ala 210 215 220 Pro Lys Thr Leu Ser Ser Phe Phe Thr Pro Arg Lys Pro Ala Val Lys 225 230 235 240 Lys Glu Val Lys Glu Glu Glu Pro Gly Ala Pro Gly Lys Glu Gly Ala 245 250 255 Ala Glu Gly Pro Leu Asp Pro Ser Gly Tyr Asn Pro Ala Lys Asn Asn 260 265 270 Tyr His Pro Val Glu Asp Ala Cys Trp Lys Pro Gly Gln Lys Val Pro 275 280 285 Tyr Leu Ala Val Ala Arg Thr Phe Glu Lys Ile Glu Glu Val Ser Ala 290 295 300 Arg Leu Arg Met Val Glu Thr Leu Ser Asn Leu Leu Arg Ser Val Val 305 310 315 320 Ala Leu Ser Pro Pro Asp Leu Leu Pro Val Leu Tyr Leu Ser Leu Asn 325 330 335 His Leu Gly Pro Pro Gln Gln Gly Leu Glu Leu Gly Val Gly Asp Gly 340 345 350 Val Leu Leu Lys Ala Val Ala Gln Ala Thr Gly Arg Gln Leu Glu Ser 355 360 365 Val Arg Ala Glu Ala Ala Glu Lys Gly Asp Val Gly Leu Val Ala Glu 370 375 380 Asn Ser Arg Ser Thr Gln Arg Leu Met Leu Pro Pro Pro Pro Leu Thr 385 390 395 400 Ala Ser Gly Val Phe Ser Lys Phe Arg Asp Ile Ala Arg Leu Thr Gly 405 410 415 Ser Ala Ser Thr Ala Lys Lys Ile Asp Ile Ile Lys Gly Leu Phe Val 420 425 430 Ala Cys Arg His Ser Glu Ala Arg Phe Ile Ala Arg Ser Leu Ser Gly 435 440 445 Arg Leu Arg Leu Gly Leu Ala Glu Gln Ser Val Leu Ala Ala Leu Ser 450 455 460 Gln Ala Val Ser Leu Thr Pro Pro Gly Gln Glu Phe Pro Pro Ala Met 465 470 475 480 Val Asp Ala Gly Lys Gly Lys Thr Ala Glu Ala Arg Lys Thr Trp Leu 485 490 495 Glu Glu Gln Gly Met Ile Leu Lys Gln Thr Phe Cys Glu Val Pro Asp 500 505 510 Leu Asp Arg Ile Ile Pro Val Leu Leu Glu His Gly Leu Glu Arg Leu 515 520 525 Pro Glu His Cys Lys Leu Ser Pro Gly Ile Pro Leu Lys Pro Met Leu 530 535 540 Ala His Pro Thr Arg Gly Ile Ser Glu Val Leu Lys Arg Phe Glu Glu 545 550 555 560 Ala Ala Phe Thr Cys Glu Tyr Lys Tyr Asp Gly Gln Arg Ala Gln Ile 565 570 575 His Ala Leu Glu Gly Gly Glu Val Lys Ile Phe Ser Arg Asn Gln Glu 580 585 590 Asp Asn Thr Gly Lys Tyr Pro Asp Ile Ile Ser Arg Ile Pro Lys Ile 595 600 605 Lys Leu Pro Ser Val Thr Ser Phe Ile Leu Asp Thr Glu Ala Val Ala 610 615 620 Trp Asp Arg Glu Lys Lys Gln Ile Gln Pro Phe Gln Val Leu Thr Thr 625 630 635 640 Arg Lys Arg Lys Glu Val Asp Ala Ser Glu Ile Gln Val Gln Val Cys 645 650 655 Leu Tyr Ala Phe Asp Leu Ile Tyr Leu Asn Gly Glu Ser Leu Val Arg 660 665 670 Glu Pro Leu Ser Arg Arg Arg Gln Leu Leu Arg Glu Asn Phe Val Glu 675 680 685 Thr Glu Gly Glu Phe Val Phe Ala Thr Ser Leu Asp Thr Lys Asp Ile 690 695 700 Glu Gln Ile Ala Glu Phe Leu Glu Gln Ser Val Lys Asp Ser Cys Glu 705 710 715 720 Gly Leu Met Val Lys Thr Leu Asp Val Asp Ala Thr Tyr Glu Ile Ala 725 730 735 Lys Arg Ser His Asn Trp Leu Lys Leu Lys Lys Asp Tyr Leu Asp Gly 740 745 750 Val Gly Asp Thr Leu Asp Leu Val Val Ile Gly Ala Tyr Leu Gly Arg 755 760 765 Gly Lys Arg Ala Gly Arg Tyr Gly Gly Phe Leu Leu Ala Ser Tyr Asp 770 775 780 Glu Asp Ser Glu Glu Leu Gln Ala Ile Cys Lys Leu Gly Thr Gly Phe 785 790 795 800 Ser Asp Glu Glu Leu Glu Glu His His Gln Ser Leu Lys Ala Leu Val 805 810 815 Leu Pro Ser Pro Arg Pro Tyr Val Arg Ile Asp Gly Ala Val Ile Pro 820 825 830 Asp His Trp Leu Asp Pro Ser Ala Val Trp Glu Val Lys Cys Ala Asp 835 840 845 Leu Ser Leu Ser Pro Ile Tyr Pro Ala Ala Arg Gly Leu Val Asp Ser 850 855 860 Asp Lys Gly Ile Ser Leu Arg Phe Pro Arg Phe Ile Arg Val Arg Glu 865 870 875 880 Asp Lys Gln Pro Glu Gln Ala Thr Thr Ser Ala Gln Val Ala Cys Leu 885 890 895 Tyr Arg Lys Gln Ser Gln Ile Gln Asn Gln Gln Gly Glu Asp Ser Gly 900 905 910 Ser Asp Pro Glu Asp Thr Tyr 915 <210> 666 <211> 1107 <212> PRT <213> Homo sapiens <400> 666 Met Asp Gly Lys Arg Arg Pro Gly Pro Gly Pro Gly Val Pro Pro Lys 1 5 10 15 Arg Ala Arg Gly Gly Leu Trp Asp Asp Asp Asp Ala Pro Trp Pro Ser 20 25 30 Gln Phe Glu Glu Asp Leu Ala Leu Met Glu Glu Met Glu Ala Glu His 35 40 45 Arg Leu Gln Glu Gln Glu Glu Glu Glu Leu Gln Ser Val Leu Glu Gly 50 55 60 Val Ala Asp Gly Gln Val Pro Pro Ser Ala Ile Asp Pro Arg Trp Leu 65 70 75 80 Arg Pro Thr Pro Pro Ala Leu Asp Pro Gln Thr Glu Pro Leu Ile Phe 85 90 95 Gln Gln Leu Glu Ile Asp His Tyr Val Gly Pro Ala Gln Pro Val Pro 100 105 110 Gly Gly Pro Pro Pro Ser Arg Gly Ser Val Pro Val Leu Arg Ala Phe 115 120 125 Gly Val Thr Asp Glu Gly Phe Ser Val Cys Cys His Ile His Gly Phe 130 135 140 Ala Pro Tyr Phe Tyr Thr Pro Ala Pro Pro Gly Phe Gly Pro Glu His 145 150 155 160 Met Gly Asp Leu Gln Arg Glu Leu Asn Leu Ala Ile Ser Arg Asp Ser 165 170 175 Arg Gly Gly Arg Glu Leu Thr Gly Pro Ala Val Leu Ala Val Glu Leu 180 185 190 Cys Ser Arg Glu Ser Met Phe Gly Tyr His Gly His Gly Pro Ser Pro 195 200 205 Phe Leu Arg Ile Thr Val Ala Leu Pro Arg Leu Val Ala Pro Ala Arg 210 215 220 Arg Leu Leu Glu Gln Gly Ile Arg Val Ala Gly Leu Gly Thr Pro Ser 225 230 235 240 Phe Ala Pro Tyr Glu Ala Asn Val Asp Phe Glu Ile Arg Phe Met Val 245 250 255 Asp Thr Asp Ile Val Gly Cys Asn Trp Leu Glu Leu Pro Ala Gly Lys 260 265 270 Tyr Ala Leu Arg Leu Lys Glu Lys Ala Thr Gln Cys Gln Leu Glu Ala 275 280 285 Asp Val Leu Trp Ser Asp Val Val Ser His Pro Pro Glu Gly Pro Trp 290 295 300 Gln Arg Ile Ala Pro Leu Arg Val Leu Ser Phe Asp Ile Glu Cys Ala 305 310 315 320 Gly Arg Lys Gly Ile Phe Pro Glu Pro Glu Arg Asp Pro Val Ile Gln 325 330 335 Ile Cys Ser Leu Gly Leu Arg Trp Gly Glu Pro Glu Pro Phe Leu Arg 340 345 350 Leu Ala Leu Thr Leu Arg Pro Cys Ala Pro Ile Leu Gly Ala Lys Val 355 360 365 Gln Ser Tyr Glu Lys Glu Glu Asp Leu Leu Gln Ala Trp Ser Thr Phe 370 375 380 Ile Arg Ile Met Asp Pro Asp Val Ile Thr Gly Tyr Asn Ile Gln Asn 385 390 395 400 Phe Asp Leu Pro Tyr Leu Ile Ser Arg Ala Gln Thr Leu Lys Val Gln 405 410 415 Thr Phe Pro Phe Leu Gly Arg Val Ala Gly Leu Cys Ser Asn Ile Arg 420 425 430 Asp Ser Ser Phe Gln Ser Lys Gln Thr Gly Arg Arg Asp Thr Lys Val 435 440 445 Val Ser Met Val Gly Arg Val Gln Met Asp Met Leu Gln Val Leu Leu 450 455 460 Arg Glu Tyr Lys Leu Arg Ser His Thr Leu Asn Ala Val Ser Phe His 465 470 475 480 Phe Leu Gly Glu Gln Lys Glu Asp Val Gln His Ser Ile Ile Thr Asp 485 490 495 Leu Gln Asn Gly Asn Asp Gln Thr Arg Arg Arg Leu Ala Val Tyr Cys 500 505 510 Leu Lys Asp Ala Tyr Leu Pro Leu Arg Leu Leu Glu Arg Leu Met Val 515 520 525 Leu Val Asn Ala Val Glu Met Ala Arg Val Thr Gly Val Pro Leu Ser 530 535 540 Tyr Leu Leu Ser Arg Gly Gln Gln Val Lys Val Val Ser Gln Leu Leu 545 550 555 560 Arg Gln Ala Met His Glu Gly Leu Leu Met Pro Val Val Lys Ser Glu 565 570 575 Gly Gly Glu Asp Tyr Thr Gly Ala Thr Val Ile Glu Pro Leu Lys Gly 580 585 590 Tyr Tyr Asp Val Pro Ile Ala Thr Leu Asp Phe Ser Ser Leu Tyr Pro 595 600 605 Ser Ile Met Met Ala His Asn Leu Cys Tyr Thr Thr Leu Leu Arg Pro 610 615 620 Gly Thr Ala Gln Lys Leu Gly Leu Thr Glu Asp Gln Phe Ile Arg Thr 625 630 635 640 Pro Thr Gly Asp Glu Phe Val Lys Thr Ser Val Arg Lys Gly Leu Leu 645 650 655 Pro Gln Ile Leu Glu Asn Leu Leu Ser Ala Arg Lys Arg Ala Lys Ala 660 665 670 Glu Leu Ala Lys Glu Thr Asp Pro Leu Arg Arg Gln Val Leu Asp Gly 675 680 685 Arg Gln Leu Ala Leu Lys Val Ser Ala Asn Ser Val Tyr Gly Phe Thr 690 695 700 Gly Ala Gln Val Gly Lys Leu Pro Cys Leu Glu Ile Ser Gln Ser Val 705 710 715 720 Thr Gly Phe Gly Arg Gln Met Ile Glu Lys Thr Lys Gln Leu Val Glu 725 730 735 Ser Lys Tyr Thr Val Glu Asn Gly Tyr Ser Thr Ser Ala Lys Val Val 740 745 750 Tyr Gly Asp Thr Asp Ser Val Met Cys Arg Phe Gly Val Ser Ser Val 755 760 765 Ala Glu Ala Met Ala Leu Gly Arg Glu Ala Ala Asp Trp Val Ser Gly 770 775 780 His Phe Pro Ser Pro Ile Arg Leu Glu Phe Glu Lys Val Tyr Phe Pro 785 790 795 800 Tyr Leu Leu Ile Ser Lys Lys Arg Tyr Ala Gly Leu Leu Phe Ser Ser 805 810 815 Arg Pro Asp Ala His Asp Arg Met Asp Cys Lys Gly Leu Glu Ala Val 820 825 830 Arg Arg Asp Asn Cys Pro Leu Val Ala Asn Leu Val Thr Ala Ser Leu 835 840 845 Arg Arg Leu Leu Ile Asp Arg Asp Pro Glu Gly Ala Val Ala His Ala 850 855 860 Gln Asp Val Ile Ser Asp Leu Leu Cys Asn Arg Ile Asp Ile Ser Gln 865 870 875 880 Leu Val Ile Thr Lys Glu Leu Thr Arg Ala Ala Ser Asp Tyr Ala Gly 885 890 895 Lys Gln Ala His Val Glu Leu Ala Glu Arg Met Arg Lys Arg Asp Pro 900 905 910 Gly Ser Ala Pro Ser Leu Gly Asp Arg Val Pro Tyr Val Ile Ile Ser 915 920 925 Ala Ala Lys Gly Val Ala Ala Tyr Met Lys Ser Glu Asp Pro Leu Phe 930 935 940 Val Leu Glu His Ser Leu Pro Ile Asp Thr Gln Tyr Tyr Leu Glu Gln 945 950 955 960 Gln Leu Ala Lys Pro Leu Leu Arg Ile Phe Glu Pro Ile Leu Gly Glu 965 970 975 Gly Arg Ala Glu Ala Val Leu Leu Arg Gly Asp His Thr Arg Cys Lys 980 985 990 Thr Val Leu Thr Gly Lys Val Gly Gly Leu Leu Ala Phe Ala Lys Arg 995 1000 1005 Arg Asn Cys Cys Ile Gly Cys Arg Thr Val Leu Ser His Gln Gly 1010 1015 1020 Ala Val Cys Glu Phe Cys Gln Pro Arg Glu Ser Glu Leu Tyr Gln 1025 1030 1035 Lys Glu Val Ser His Leu Asn Ala Leu Glu Glu Arg Phe Ser Arg 1040 1045 1050 Leu Trp Thr Gln Cys Gln Arg Cys Gln Gly Ser Leu His Glu Asp 1055 1060 1065 Val Ile Cys Thr Ser Arg Asp Cys Pro Ile Phe Tyr Met Arg Lys 1070 1075 1080 Lys Val Arg Lys Asp Leu Glu Asp Gln Glu Gln Leu Leu Arg Arg 1085 1090 1095 Phe Gly Pro Pro Gly Pro Glu Ala Trp 1100 1105 <210> 667 <211> 2286 <212> PRT <213> Homo sapiens <400> 667 Met Ser Leu Arg Ser Gly Gly Arg Arg Arg Ala Asp Pro Gly Ala Asp 1 5 10 15 Gly Glu Ala Ser Arg Asp Asp Gly Ala Thr Ser Ser Val Ser Ala Leu 20 25 30 Lys Arg Leu Glu Arg Ser Gln Trp Thr Asp Lys Met Asp Leu Arg Phe 35 40 45 Gly Phe Glu Arg Leu Lys Glu Pro Gly Glu Lys Thr Gly Trp Leu Ile 50 55 60 Asn Met His Pro Thr Glu Ile Leu Asp Glu Asp Lys Arg Leu Gly Ser 65 70 75 80 Ala Val Asp Tyr Tyr Phe Ile Gln Asp Asp Gly Ser Arg Phe Lys Val 85 90 95 Ala Leu Pro Tyr Lys Pro Tyr Phe Tyr Ile Ala Thr Arg Lys Gly Cys 100 105 110 Glu Arg Glu Val Ser Ser Phe Leu Ser Lys Lys Phe Gln Gly Lys Ile 115 120 125 Ala Lys Val Glu Thr Val Pro Lys Glu Asp Leu Asp Leu Pro Asn His 130 135 140 Leu Val Gly Leu Lys Arg Asn Tyr Ile Arg Leu Ser Phe His Thr Val 145 150 155 160 Glu Asp Leu Val Lys Val Arg Lys Glu Ile Ser Pro Ala Val Lys Lys 165 170 175 Asn Arg Glu Gln Asp His Ala Ser Asp Ala Tyr Thr Ala Leu Leu Ser 180 185 190 Ser Val Leu Gln Arg Gly Gly Val Ile Thr Asp Glu Glu Glu Thr Ser 195 200 205 Lys Lys Ile Ala Asp Gln Leu Asp Asn Ile Val Asp Met Arg Glu Tyr 210 215 220 Asp Val Pro Tyr His Ile Arg Leu Ser Ile Asp Leu Lys Ile His Val 225 230 235 240 Ala His Trp Tyr Asn Val Arg Tyr Arg Gly Asn Ala Phe Pro Val Glu 245 250 255 Ile Thr Arg Arg Asp Asp Leu Val Glu Arg Pro Asp Pro Val Val Leu 260 265 270 Ala Phe Asp Ile Glu Thr Thr Lys Leu Pro Leu Lys Phe Pro Asp Ala 275 280 285 Glu Thr Asp Gln Ile Met Met Ile Ser Tyr Met Ile Asp Gly Gln Gly 290 295 300 Tyr Leu Ile Thr Asn Arg Glu Ile Val Ser Glu Asp Ile Glu Asp Phe 305 310 315 320 Glu Phe Thr Pro Lys Pro Glu Tyr Glu Gly Pro Phe Cys Val Phe Asn 325 330 335 Glu Pro Asp Glu Ala His Leu Ile Gln Arg Trp Phe Glu His Val Gln 340 345 350 Glu Thr Lys Pro Thr Ile Met Val Thr Tyr Asn Gly Asp Phe Phe Asp 355 360 365 Trp Pro Phe Val Glu Ala Arg Ala Ala Val His Gly Leu Ser Met Gln 370 375 380 Gln Glu Ile Gly Phe Gln Lys Asp Ser Gln Gly Glu Tyr Lys Ala Pro 385 390 395 400 Gln Cys Ile His Met Asp Cys Leu Arg Trp Val Lys Arg Asp Ser Tyr 405 410 415 Leu Pro Val Gly Ser His Asn Leu Lys Ala Ala Ala Lys Ala Lys Leu 420 425 430 Gly Tyr Asp Pro Val Glu Leu Asp Pro Glu Asp Met Cys Arg Met Ala 435 440 445 Thr Glu Gln Pro Gln Thr Leu Ala Thr Tyr Ser Val Ser Asp Ala Val 450 455 460 Ala Thr Tyr Tyr Leu Tyr Met Lys Tyr Val His Pro Phe Ile Phe Ala 465 470 475 480 Leu Cys Thr Ile Ile Pro Met Glu Pro Asp Glu Val Leu Arg Lys Gly 485 490 495 Ser Gly Thr Leu Cys Glu Ala Leu Leu Met Val Gln Ala Phe His Ala 500 505 510 Asn Ile Ile Phe Pro Asn Lys Gln Glu Gln Glu Phe Asn Lys Leu Thr 515 520 525 Asp Asp Gly His Val Leu Asp Ser Glu Thr Tyr Val Gly Gly His Val 530 535 540 Glu Ala Leu Glu Ser Gly Val Phe Arg Ser Asp Ile Pro Cys Arg Phe 545 550 555 560 Arg Met Asn Pro Ala Ala Phe Asp Phe Leu Leu Gln Arg Val Glu Lys 565 570 575 Thr Leu Arg His Ala Leu Glu Glu Glu Glu Lys Val Pro Val Glu Gln 580 585 590 Val Thr Asn Phe Glu Glu Val Cys Asp Glu Ile Lys Ser Lys Leu Ala 595 600 605 Ser Leu Lys Asp Val Pro Ser Arg Ile Glu Cys Pro Leu Ile Tyr His 610 615 620 Leu Asp Val Gly Ala Met Tyr Pro Asn Ile Ile Leu Thr Asn Arg Leu 625 630 635 640 Gln Pro Ser Ala Met Val Asp Glu Ala Thr Cys Ala Ala Cys Asp Phe 645 650 655 Asn Lys Pro Gly Ala Asn Cys Gln Arg Lys Met Ala Trp Gln Trp Arg 660 665 670 Gly Glu Phe Met Pro Ala Ser Arg Ser Glu Tyr His Arg Ile Gln His 675 680 685 Gln Leu Glu Ser Glu Lys Phe Pro Pro Leu Phe Pro Glu Gly Pro Ala 690 695 700 Arg Ala Phe His Glu Leu Ser Arg Glu Glu Gln Ala Lys Tyr Glu Lys 705 710 715 720 Arg Arg Leu Ala Asp Tyr Cys Arg Lys Ala Tyr Lys Lys Ile His Ile 725 730 735 Thr Lys Val Glu Glu Arg Leu Thr Thr Ile Cys Gln Arg Glu Asn Ser 740 745 750 Phe Tyr Val Asp Thr Val Arg Ala Phe Arg Asp Arg Arg Tyr Glu Phe 755 760 765 Lys Gly Leu His Lys Val Trp Lys Lys Lys Leu Ser Ala Ala Val Glu 770 775 780 Val Gly Asp Ala Ala Glu Val Lys Arg Cys Lys Asn Met Glu Val Leu 785 790 795 800 Tyr Asp Ser Leu Gln Leu Ala His Lys Cys Ile Leu Asn Ser Phe Tyr 805 810 815 Gly Tyr Val Met Arg Lys Gly Ala Arg Trp Tyr Ser Met Glu Met Ala 820 825 830 Gly Ile Val Cys Phe Thr Gly Ala Asn Ile Ile Thr Gln Ala Arg Glu 835 840 845 Leu Ile Glu Gln Ile Gly Arg Pro Leu Glu Leu Asp Thr Asp Gly Ile 850 855 860 Trp Cys Val Leu Pro Asn Ser Phe Pro Glu Asn Phe Val Phe Lys Thr 865 870 875 880 Thr Asn Val Lys Lys Pro Lys Val Thr Ile Ser Tyr Pro Gly Ala Met 885 890 895 Leu Asn Ile Met Val Lys Glu Gly Phe Thr Asn Asp Gln Tyr Gln Glu 900 905 910 Leu Ala Glu Pro Ser Ser Leu Thr Tyr Val Thr Arg Ser Glu Asn Ser 915 920 925 Ile Phe Phe Glu Val Asp Gly Pro Tyr Leu Ala Met Ile Leu Pro Ala 930 935 940 Ser Lys Glu Glu Gly Lys Lys Leu Lys Lys Arg Tyr Ala Val Phe Asn 945 950 955 960 Glu Asp Gly Ser Leu Ala Glu Leu Lys Gly Phe Glu Val Lys Arg Arg 965 970 975 Gly Glu Leu Gln Leu Ile Lys Ile Phe Gln Ser Ser Val Phe Glu Ala 980 985 990 Phe Leu Lys Gly Ser Thr Leu Glu Glu Val Tyr Gly Ser Val Ala Lys 995 1000 1005 Val Ala Asp Tyr Trp Leu Asp Val Leu Tyr Ser Lys Ala Ala Asn 1010 1015 1020 Met Pro Asp Ser Glu Leu Phe Glu Leu Ile Ser Glu Asn Arg Ser 1025 1030 1035 Met Ser Arg Lys Leu Glu Asp Tyr Gly Glu Gln Lys Ser Thr Ser 1040 1045 1050 Ile Ser Thr Ala Lys Arg Leu Ala Glu Phe Leu Gly Asp Gln Met 1055 1060 1065 Val Lys Asp Ala Gly Leu Ser Cys Arg Tyr Ile Ile Ser Arg Lys 1070 1075 1080 Pro Glu Gly Ser Pro Val Thr Glu Arg Ala Ile Pro Leu Ala Ile 1085 1090 1095 Phe Gln Ala Glu Pro Thr Val Arg Lys His Phe Leu Arg Lys Trp 1100 1105 1110 Leu Lys Ser Ser Ser Leu Gln Asp Phe Asp Ile Arg Ala Ile Leu 1115 1120 1125 Asp Trp Asp Tyr Tyr Ile Glu Arg Leu Gly Ser Ala Ile Gln Lys 1130 1135 1140 Ile Ile Thr Ile Pro Ala Ala Leu Gln Gln Val Lys Asn Pro Val 1145 1150 1155 Pro Arg Val Lys His Pro Asp Trp Leu His Lys Lys Leu Leu Glu 1160 1165 1170 Lys Asn Asp Val Tyr Lys Gln Lys Lys Ile Ser Glu Leu Phe Thr 1175 1180 1185 Leu Glu Gly Arg Arg Gln Val Thr Met Ala Glu Ala Ser Glu Asp 1190 1195 1200 Ser Pro Arg Pro Ser Ala Pro Asp Met Glu Asp Phe Gly Leu Val 1205 1210 1215 Lys Leu Pro His Pro Ala Ala Pro Val Thr Val Lys Arg Lys Arg 1220 1225 1230 Val Leu Trp Glu Ser Gln Glu Glu Ser Gln Asp Leu Thr Pro Thr 1235 1240 1245 Val Pro Trp Gln Glu Ile Leu Gly Gln Pro Pro Ala Leu Gly Thr 1250 1255 1260 Ser Gln Glu Glu Trp Leu Val Trp Leu Arg Phe His Lys Lys Lys 1265 1270 1275 Trp Gln Leu Gln Ala Arg Gln Arg Leu Ala Arg Arg Lys Arg Gln 1280 1285 1290 Arg Leu Glu Ser Ala Glu Gly Val Leu Arg Pro Gly Ala Ile Arg 1295 1300 1305 Asp Gly Pro Ala Thr Gly Leu Gly Ser Phe Leu Arg Arg Thr Ala 1310 1315 1320 Arg Ser Ile Leu Asp Leu Pro Trp Gln Ile Val Gln Ile Ser Glu 1325 1330 1335 Thr Ser Gln Ala Gly Leu Phe Arg Leu Trp Ala Leu Val Gly Ser 1340 1345 1350 Asp Leu His Cys Ile Arg Leu Ser Ile Pro Arg Val Phe Tyr Val 1355 1360 1365 Asn Gln Arg Val Ala Lys Ala Glu Glu Gly Ala Ser Tyr Arg Lys 1370 1375 1380 Val Asn Arg Val Leu Pro Arg Ser Asn Met Val Tyr Asn Leu Tyr 1385 1390 1395 Glu Tyr Ser Val Pro Glu Asp Met Tyr Gln Glu His Ile Asn Glu 1400 1405 1410 Ile Asn Ala Glu Leu Ser Ala Pro Asp Ile Glu Gly Val Tyr Glu 1415 1420 1425 Thr Gln Val Pro Leu Leu Phe Arg Ala Leu Val His Leu Gly Cys 1430 1435 1440 Val Cys Val Val Asn Lys Gln Leu Val Arg His Leu Ser Gly Trp 1445 1450 1455 Glu Ala Glu Thr Phe Ala Leu Glu His Leu Glu Met Arg Ser Leu 1460 1465 1470 Ala Gln Phe Ser Tyr Leu Glu Pro Gly Ser Ile Arg His Ile Tyr 1475 1480 1485 Leu Tyr His His Ala Gln Ala His Lys Ala Leu Phe Gly Ile Phe 1490 1495 1500 Ile Pro Ser Gln Arg Arg Ala Ser Val Phe Val Leu Asp Thr Val 1505 1510 1515 Arg Ser Asn Gln Met Pro Ser Leu Gly Ala Leu Tyr Ser Ala Glu 1520 1525 1530 His Gly Leu Leu Leu Glu Lys Val Gly Pro Glu Leu Leu Pro Pro 1535 1540 1545 Pro Lys His Thr Phe Glu Val Arg Ala Glu Thr Asp Leu Lys Thr 1550 1555 1560 Ile Cys Arg Ala Ile Gln Arg Phe Leu Leu Ala Tyr Lys Glu Glu 1565 1570 1575 Arg Arg Gly Pro Thr Leu Ile Ala Val Gln Ser Ser Trp Glu Leu 1580 1585 1590 Lys Arg Leu Ala Ser Glu Ile Pro Val Leu Glu Glu Phe Pro Leu 1595 1600 1605 Val Pro Ile Cys Val Ala Asp Lys Ile Asn Tyr Gly Val Leu Asp 1610 1615 1620 Trp Gln Arg His Gly Ala Arg Arg Met Ile Arg His Tyr Leu Asn 1625 1630 1635 Leu Asp Thr Cys Leu Ser Gln Ala Phe Glu Met Ser Arg Tyr Phe 1640 1645 1650 His Ile Pro Ile Gly Asn Leu Pro Glu Asp Ile Ser Thr Phe Gly 1655 1660 1665 Ser Asp Leu Phe Phe Ala Arg His Leu Gln Arg His Asn His Leu 1670 1675 1680 Leu Trp Leu Ser Pro Thr Ala Arg Pro Asp Leu Gly Gly Lys Glu 1685 1690 1695 Ala Asp Asp Asn Cys Leu Val Met Glu Phe Asp Asp Gln Ala Thr 1700 1705 1710 Val Glu Ile Asn Ser Ser Gly Cys Tyr Ser Thr Val Cys Val Glu 1715 1720 1725 Leu Asp Leu Gln Asn Leu Ala Val Asn Thr Ile Leu Gln Ser His 1730 1735 1740 His Val Asn Asp Met Glu Gly Ala Asp Ser Met Gly Ile Ser Phe 1745 1750 1755 Asp Val Ile Gln Gln Ala Ser Leu Glu Asp Met Ile Thr Gly Gly 1760 1765 1770 Gln Ala Ala Ser Ala Pro Ala Ser Tyr Asp Glu Thr Ala Leu Cys 1775 1780 1785 Ser Asn Thr Phe Arg Ile Leu Lys Ser Met Val Val Gly Trp Val 1790 1795 1800 Lys Glu Ile Thr Gln Tyr His Asn Ile Tyr Ala Asp Asn Gln Val 1805 1810 1815 Met His Phe Tyr Arg Trp Leu Arg Ser Pro Ser Ser Leu Leu His 1820 1825 1830 Asp Pro Ala Leu His Arg Thr Leu His Asn Met Met Lys Lys Leu 1835 1840 1845 Phe Leu Gln Leu Ile Ala Glu Phe Lys Arg Leu Gly Ser Ser Val 1850 1855 1860 Ile Tyr Ala Asn Phe Asn Arg Ile Ile Leu Cys Thr Lys Lys Arg 1865 1870 1875 Arg Val Glu Asp Ala Ile Ala Tyr Val Glu Tyr Ile Thr Ser Ser 1880 1885 1890 Ile His Ser Lys Glu Thr Phe His Ser Leu Thr Ile Ser Phe Ser 1895 1900 1905 Arg Cys Trp Glu Phe Leu Leu Trp Met Asp Pro Ser Asn Tyr Gly 1910 1915 1920 Gly Ile Lys Gly Lys Val Ser Ser Arg Ile His Cys Gly Leu Gln 1925 1930 1935 Asp Ser Gln Lys Ala Gly Gly Ala Glu Asp Glu Gln Glu Asn Glu 1940 1945 1950 Asp Asp Glu Glu Glu Arg Asp Gly Glu Glu Glu Glu Glu Ala Glu 1955 1960 1965 Glu Ser Asn Val Glu Asp Leu Leu Glu Asn Asn Trp Asn Ile Leu 1970 1975 1980 Gln Phe Leu Pro Gln Ala Ala Ser Cys Gln Asn Tyr Phe Leu Met 1985 1990 1995 Ile Val Ser Ala Tyr Ile Val Ala Val Tyr His Cys Met Lys Asp 2000 2005 2010 Gly Leu Arg Arg Ser Ala Pro Gly Ser Thr Pro Val Arg Arg Arg 2015 2020 2025 Gly Ala Ser Gln Leu Ser Gln Glu Ala Glu Gly Ala Val Gly Ala 2030 2035 2040 Leu Pro Gly Met Ile Thr Phe Ser Gln Asp Tyr Val Ala Asn Glu 2045 2050 2055 Leu Thr Gln Ser Phe Phe Thr Ile Thr Gln Lys Ile Gln Lys Lys 2060 2065 2070 Val Thr Gly Ser Arg Asn Ser Thr Glu Leu Ser Glu Met Phe Pro 2075 2080 2085 Val Leu Pro Gly Ser His Leu Leu Leu Asn Asn Pro Ala Leu Glu 2090 2095 2100 Phe Ile Lys Tyr Val Cys Lys Val Leu Ser Leu Asp Thr Asn Ile 2105 2110 2115 Thr Asn Gln Val Asn Lys Leu Asn Arg Asp Leu Leu Arg Leu Val 2120 2125 2130 Asp Val Gly Glu Phe Ser Glu Glu Ala Gln Phe Arg Asp Pro Cys 2135 2140 2145 Arg Ser Tyr Val Leu Pro Glu Val Ile Cys Arg Ser Cys Asn Phe 2150 2155 2160 Cys Arg Asp Leu Asp Leu Cys Lys Asp Ser Ser Phe Ser Glu Asp 2165 2170 2175 Gly Ala Val Leu Pro Gln Trp Leu Cys Ser Asn Cys Gln Ala Pro 2180 2185 2190 Tyr Asp Ser Ser Ala Ile Glu Met Thr Leu Val Glu Val Leu Gln 2195 2200 2205 Lys Lys Leu Met Ala Phe Thr Leu Gln Asp Leu Val Cys Leu Lys 2210 2215 2220 Cys Arg Gly Val Lys Glu Thr Ser Met Pro Val Tyr Cys Thr Cys 2225 2230 2235 Ala Gly Asp Phe Ala Leu Thr Ile His Thr Gln Val Phe Met Glu 2240 2245 2250 Gln Ile Gly Ile Phe Arg Asn Ile Ala Gln His Tyr Gly Met Ser 2255 2260 2265 Tyr Leu Leu Glu Thr Leu Glu Trp Leu Leu Gln Lys Asn Pro Gln 2270 2275 2280 Leu Gly His 2285 <210> 668 <211> 147 <212> PRT <213> Homo sapiens <400> 668 Met Ala Glu Arg Pro Glu Asp Leu Asn Leu Pro Asn Ala Val Ile Thr 1 5 10 15 Arg Ile Ile Lys Glu Ala Leu Pro Asp Gly Val Asn Ile Ser Lys Glu 20 25 30 Ala Arg Ser Ala Ile Ser Arg Ala Ala Ser Val Phe Val Leu Tyr Ala 35 40 45 Thr Ser Cys Ala Asn Asn Phe Ala Met Lys Gly Lys Arg Lys Thr Leu 50 55 60 Asn Ala Ser Asp Val Leu Ser Ala Met Glu Glu Met Glu Phe Gln Arg 65 70 75 80 Phe Val Ile Pro Leu Lys Glu Ala Leu Glu Ala Tyr Arg Arg Glu Gln 85 90 95 Lys Gly Lys Lys Glu Ala Ser Glu Gln Lys Lys Lys Asp Lys Asp Lys 100 105 110 Lys Thr Asp Ser Glu Glu Gln Asp Lys Ser Arg Asp Glu Asp Asn Asp 115 120 125 Glu Asp Glu Glu Arg Leu Glu Glu Glu Glu Gln Asn Glu Glu Glu Glu 130 135 140 Val Asp Asn 145 <210> 669 <211> 117 <212> PRT <213> Homo sapiens <400> 669 Met Ala Ala Ala Ala Ala Ala Gly Ser Gly Thr Pro Arg Glu Glu Glu 1 5 10 15 Gly Pro Ala Gly Glu Ala Ala Ala Ser Gln Pro Gln Ala Pro Thr Ser 20 25 30 Val Pro Gly Ala Arg Leu Ser Arg Leu Pro Leu Ala Arg Val Lys Ala 35 40 45 Leu Val Lys Ala Asp Pro Asp Val Thr Leu Ala Gly Gln Glu Ala Ile 50 55 60 Phe Ile Leu Ala Arg Ala Ala Glu Leu Phe Val Glu Thr Ile Ala Lys 65 70 75 80 Asp Ala Tyr Cys Cys Ala Gln Gln Gly Lys Arg Lys Thr Leu Gln Arg 85 90 95 Arg Asp Leu Asp Asn Ala Ile Glu Ala Val Asp Glu Phe Ala Phe Leu 100 105 110 Glu Gly Thr Leu Asp 115 <210> 670 <211> 765 <212> PRT <213> Homo sapiens <400> 670 Met Ser Gly Asp His Leu His Asn Asp Ser Gln Ile Glu Ala Asp Phe 1 5 10 15 Arg Leu Asn Asp Ser His Lys His Lys Asp Lys His Lys Asp Arg Glu 20 25 30 His Arg His Lys Glu His Lys Lys Glu Lys Asp Arg Glu Lys Ser Lys 35 40 45 His Ser Asn Ser Glu His Lys Asp Ser Glu Lys Lys His Lys Glu Lys 50 55 60 Glu Lys Thr Lys His Lys Asp Gly Ser Ser Glu Lys His Lys Asp Lys 65 70 75 80 His Lys Asp Arg Asp Lys Glu Lys Arg Lys Glu Glu Lys Val Arg Ala 85 90 95 Ser Gly Asp Ala Lys Ile Lys Lys Glu Lys Glu Asn Gly Phe Ser Ser 100 105 110 Pro Pro Gln Ile Lys Asp Glu Pro Glu Asp Asp Gly Tyr Phe Val Pro 115 120 125 Pro Lys Glu Asp Ile Lys Pro Leu Lys Arg Pro Arg Asp Glu Asp Asp 130 135 140 Ala Asp Tyr Lys Pro Lys Lys Ile Lys Thr Glu Asp Thr Lys Lys Glu 145 150 155 160 Lys Lys Arg Lys Leu Glu Glu Glu Glu Asp Gly Lys Leu Lys Lys Pro 165 170 175 Lys Asn Lys Asp Lys Asp Lys Lys Val Pro Glu Pro Asp Asn Lys Lys 180 185 190 Lys Lys Pro Lys Lys Glu Glu Glu Gln Lys Trp Lys Trp Trp Glu Glu 195 200 205 Glu Arg Tyr Pro Glu Gly Ile Lys Trp Lys Phe Leu Glu His Lys Gly 210 215 220 Pro Val Phe Ala Pro Pro Tyr Glu Pro Leu Pro Glu Asn Val Lys Phe 225 230 235 240 Tyr Tyr Asp Gly Lys Val Met Lys Leu Ser Pro Lys Ala Glu Glu Val 245 250 255 Ala Thr Phe Phe Ala Lys Met Leu Asp His Glu Tyr Thr Thr Lys Glu 260 265 270 Ile Phe Arg Lys Asn Phe Phe Lys Asp Trp Arg Lys Glu Met Thr Asn 275 280 285 Glu Glu Lys Asn Ile Ile Thr Asn Leu Ser Lys Cys Asp Phe Thr Gln 290 295 300 Met Ser Gln Tyr Phe Lys Ala Gln Thr Glu Ala Arg Lys Gln Met Ser 305 310 315 320 Lys Glu Glu Lys Leu Lys Ile Lys Glu Glu Asn Glu Lys Leu Leu Lys 325 330 335 Glu Tyr Gly Phe Cys Ile Met Asp Asn His Lys Glu Arg Ile Ala Asn 340 345 350 Phe Lys Ile Glu Pro Pro Gly Leu Phe Arg Gly Arg Gly Asn His Pro 355 360 365 Lys Met Gly Met Leu Lys Arg Arg Ile Met Pro Glu Asp Ile Ile Ile 370 375 380 Asn Cys Ser Lys Asp Ala Lys Val Pro Ser Pro Pro Pro Gly His Lys 385 390 395 400 Trp Lys Glu Val Arg His Asp Asn Lys Val Thr Trp Leu Val Ser Trp 405 410 415 Thr Glu Asn Ile Gln Gly Ser Ile Lys Tyr Ile Met Leu Asn Pro Ser 420 425 430 Ser Arg Ile Lys Gly Glu Lys Asp Trp Gln Lys Tyr Glu Thr Ala Arg 435 440 445 Arg Leu Lys Lys Cys Val Asp Lys Ile Arg Asn Gln Tyr Arg Glu Asp 450 455 460 Trp Lys Ser Lys Glu Met Lys Val Arg Gln Arg Ala Val Ala Leu Tyr 465 470 475 480 Phe Ile Asp Lys Leu Ala Leu Arg Ala Gly Asn Glu Lys Glu Glu Gly 485 490 495 Glu Thr Ala Asp Thr Val Gly Cys Cys Ser Leu Arg Val Glu His Ile 500 505 510 Asn Leu His Pro Glu Leu Asp Gly Gln Glu Tyr Val Val Glu Phe Asp 515 520 525 Phe Leu Gly Lys Asp Ser Ile Arg Tyr Tyr Asn Lys Val Pro Val Glu 530 535 540 Lys Arg Val Phe Lys Asn Leu Gln Leu Phe Met Glu Asn Lys Gln Pro 545 550 555 560 Glu Asp Asp Leu Phe Asp Arg Leu Asn Thr Gly Ile Leu Asn Lys His 565 570 575 Leu Gln Asp Leu Met Glu Gly Leu Thr Ala Lys Val Phe Arg Thr Tyr 580 585 590 Asn Ala Ser Ile Thr Leu Gln Gln Gln Leu Lys Glu Leu Thr Ala Pro 595 600 605 Asp Glu Asn Ile Pro Ala Lys Ile Leu Ser Tyr Asn Arg Ala Asn Arg 610 615 620 Ala Val Ala Ile Leu Cys Asn His Gln Arg Ala Pro Pro Lys Thr Phe 625 630 635 640 Glu Lys Ser Met Met Asn Leu Gln Thr Lys Ile Asp Ala Lys Lys Glu 645 650 655 Gln Leu Ala Asp Ala Arg Arg Asp Leu Lys Ser Ala Lys Ala Asp Ala 660 665 670 Lys Val Met Lys Asp Ala Lys Thr Lys Lys Val Val Glu Ser Lys Lys 675 680 685 Lys Ala Val Gln Arg Leu Glu Glu Gln Leu Met Lys Leu Glu Val Gln 690 695 700 Ala Thr Asp Arg Glu Glu Asn Lys Gln Ile Ala Leu Gly Thr Ser Lys 705 710 715 720 Leu Asn Tyr Leu Asp Pro Arg Ile Thr Val Ala Trp Cys Lys Lys Trp 725 730 735 Gly Val Pro Ile Glu Lys Ile Tyr Asn Lys Thr Gln Arg Glu Lys Phe 740 745 750 Ala Trp Ala Ile Asp Met Ala Asp Glu Asp Tyr Glu Phe 755 760 765 <210> 671 <211> 608 <212> PRT <213> Homo sapiens <400> 671 Met Ser Gln Glu Gly Asp Tyr Gly Arg Trp Thr Ile Ser Ser Ser Asp 1 5 10 15 Glu Ser Glu Glu Glu Lys Pro Lys Pro Asp Lys Pro Ser Thr Ser Ser 20 25 30 Leu Leu Cys Ala Arg Gln Gly Ala Ala Asn Glu Pro Arg Tyr Thr Cys 35 40 45 Ser Glu Ala Gln Lys Ala Ala His Lys Arg Lys Ile Ser Pro Val Lys 50 55 60 Phe Ser Asn Thr Asp Ser Val Leu Pro Pro Lys Arg Gln Lys Ser Gly 65 70 75 80 Ser Gln Glu Asp Leu Gly Trp Cys Leu Ser Ser Ser Asp Asp Glu Leu 85 90 95 Gln Pro Glu Met Pro Gln Lys Gln Ala Glu Lys Val Val Ile Lys Lys 100 105 110 Glu Lys Asp Ile Ser Ala Pro Asn Asp Gly Thr Ala Gln Arg Thr Glu 115 120 125 Asn His Gly Ala Pro Ala Cys His Arg Leu Lys Glu Glu Glu Asp Glu 130 135 140 Tyr Glu Thr Ser Gly Glu Gly Gln Asp Ile Trp Asp Met Leu Asp Lys 145 150 155 160 Gly Asn Pro Phe Gln Phe Tyr Leu Thr Arg Val Ser Gly Val Lys Pro 165 170 175 Lys Tyr Asn Ser Gly Ala Leu His Ile Lys Asp Ile Leu Ser Pro Leu 180 185 190 Phe Gly Thr Leu Val Ser Ser Ala Gln Phe Asn Tyr Cys Phe Asp Val 195 200 205 Asp Trp Leu Val Lys Gln Tyr Pro Pro Glu Phe Arg Lys Lys Pro Ile 210 215 220 Leu Leu Val His Gly Asp Lys Arg Glu Ala Lys Ala His Leu His Ala 225 230 235 240 Gln Ala Lys Pro Tyr Glu Asn Ile Ser Leu Cys Gln Ala Lys Leu Asp 245 250 255 Ile Ala Phe Gly Thr His His Thr Lys Met Met Leu Leu Leu Tyr Glu 260 265 270 Glu Gly Leu Arg Val Val Ile His Thr Ser Asn Leu Ile His Ala Asp 275 280 285 Trp His Gln Lys Thr Gln Gly Ile Trp Leu Ser Pro Leu Tyr Pro Arg 290 295 300 Ile Ala Asp Gly Thr His Lys Ser Gly Glu Ser Pro Thr His Phe Lys 305 310 315 320 Ala Asp Leu Ile Ser Tyr Leu Met Ala Tyr Asn Ala Pro Ser Leu Lys 325 330 335 Glu Trp Ile Asp Val Ile His Lys His Asp Leu Ser Glu Thr Asn Val 340 345 350 Tyr Leu Ile Gly Ser Thr Pro Gly Arg Phe Gln Gly Ser Gln Lys Asp 355 360 365 Asn Trp Gly His Phe Arg Leu Lys Lys Leu Leu Lys Asp His Ala Ser 370 375 380 Ser Met Pro Asn Ala Glu Ser Trp Pro Val Val Gly Gln Phe Ser Ser 385 390 395 400 Val Gly Ser Leu Gly Ala Asp Glu Ser Lys Trp Leu Cys Ser Glu Phe 405 410 415 Lys Glu Ser Met Leu Thr Leu Gly Lys Glu Ser Lys Thr Pro Gly Lys 420 425 430 Ser Ser Val Pro Leu Tyr Leu Ile Tyr Pro Ser Val Glu Asn Val Arg 435 440 445 Thr Ser Leu Glu Gly Tyr Pro Ala Gly Gly Ser Leu Pro Tyr Ser Ile 450 455 460 Gln Thr Ala Glu Lys Gln Asn Trp Leu His Ser Tyr Phe His Lys Trp 465 470 475 480 Ser Ala Glu Thr Ser Gly Arg Ser Asn Ala Met Pro His Ile Lys Thr 485 490 495 Tyr Met Arg Pro Ser Pro Asp Phe Ser Lys Ile Ala Trp Phe Leu Val 500 505 510 Thr Ser Ala Asn Leu Ser Lys Ala Ala Trp Gly Ala Leu Glu Lys Asn 515 520 525 Gly Thr Gln Leu Met Ile Arg Ser Tyr Glu Leu Gly Val Leu Phe Leu 530 535 540 Pro Ser Ala Phe Gly Leu Asp Ser Phe Lys Val Lys Gln Lys Phe Phe 545 550 555 560 Ala Gly Ser Gln Glu Pro Met Ala Thr Phe Pro Val Pro Tyr Asp Leu 565 570 575 Pro Pro Glu Leu Tyr Gly Ser Lys Asp Arg Pro Trp Ile Trp Asn Ile 580 585 590 Pro Tyr Val Lys Ala Pro Asp Thr His Gly Asn Met Trp Val Pro Ser 595 600 605 <210> 672 <211> 975 <212> PRT <213> Homo sapiens <400> 672 Met Glu Asp Tyr Glu Gln Glu Leu Cys Gly Val Glu Asp Asp Phe His 1 5 10 15 Asn Gln Phe Ala Ala Glu Leu Glu Val Leu Ala Glu Leu Glu Gly Ala 20 25 30 Ser Thr Pro Ser Pro Ser Gly Val Pro Leu Phe Thr Ala Gly Arg Pro 35 40 45 Pro Arg Thr Phe Glu Glu Ala Leu Ala Arg Gly Asp Ala Ala Ser Ser 50 55 60 Pro Ala Pro Ala Ala Ser Val Gly Ser Ser Gln Gly Gly Ala Arg Lys 65 70 75 80 Arg Gln Val Asp Ala Asp Leu Gln Pro Ala Gly Ser Leu Pro His Ala 85 90 95 Pro Arg Ile Lys Arg Pro Arg Leu Gln Val Val Lys Arg Leu Asn Phe 100 105 110 Arg Ser Glu Glu Met Glu Glu Pro Pro Pro Pro Asp Ser Ser Pro Thr 115 120 125 Asp Ile Thr Pro Pro Pro Ser Pro Glu Asp Leu Ala Glu Leu Trp Gly 130 135 140 His Gly Val Ser Glu Ala Ala Ala Asp Val Gly Leu Thr Arg Ala Ser 145 150 155 160 Pro Ala Ala Arg Asn Pro Val Leu Arg Arg Pro Pro Ile Leu Glu Asp 165 170 175 Tyr Val His Val Thr Ser Thr Glu Gly Val Arg Ala Tyr Leu Val Leu 180 185 190 Arg Ala Asp Pro Met Ala Pro Gly Val Gln Gly Ser Leu Leu His Val 195 200 205 Pro Trp Arg Gly Gly Gly Gln Leu Asp Leu Leu Gly Val Ser Leu Ala 210 215 220 Ser Leu Lys Lys Gln Val Asp Gly Glu Arg Arg Glu Arg Leu Leu Gln 225 230 235 240 Glu Ala Gln Lys Leu Ser Asp Thr Leu His Ser Leu Arg Ser Gly Glu 245 250 255 Glu Glu Ala Ala Gln Pro Leu Gly Ala Pro Glu Glu Glu Pro Thr Asp 260 265 270 Gly Gln Asp Ala Ser Ser His Cys Leu Trp Val Asp Glu Phe Ala Pro 275 280 285 Arg His Tyr Thr Glu Leu Leu Ser Asp Asp Phe Thr Asn Arg Cys Leu 290 295 300 Leu Lys Trp Leu Lys Leu Trp Asp Leu Val Val Phe Gly His Glu Arg 305 310 315 320 Pro Ser Arg Lys Pro Arg Pro Ser Val Glu Pro Ala Arg Val Ser Lys 325 330 335 Glu Ala Thr Ala Pro Gly Lys Trp Lys Ser His Glu Gln Val Leu Glu 340 345 350 Glu Met Leu Glu Ala Gly Leu Asp Pro Ser Gln Arg Pro Lys Gln Lys 355 360 365 Val Ala Leu Leu Cys Gly Pro Pro Gly Leu Gly Lys Thr Thr Leu Ala 370 375 380 His Val Ile Ala Arg His Ala Gly Tyr Ser Val Val Glu Met Asn Ala 385 390 395 400 Ser Asp Asp Arg Ser Pro Glu Val Phe Arg Thr Arg Ile Glu Ala Ala 405 410 415 Thr Gln Met Glu Ser Val Leu Gly Ala Gly Gly Lys Pro Asn Cys Leu 420 425 430 Val Ile Asp Glu Ile Asp Gly Ala Pro Val Ala Ala Ile Asn Val Leu 435 440 445 Leu Ser Ile Leu Asn Arg Lys Gly Pro Gln Glu Val Gly Pro Gln Gly 450 455 460 Pro Ala Val Pro Ser Gly Gly Gly Arg Arg Arg Arg Ala Glu Gly Gly 465 470 475 480 Leu Leu Met Arg Pro Ile Ile Cys Ile Cys Asn Asp Gln Phe Ala Pro 485 490 495 Ser Leu Arg Gln Leu Lys Gln Gln Ala Phe Leu Leu His Phe Pro Pro 500 505 510 Thr Leu Pro Ser Arg Leu Val Gln Arg Leu Gln Glu Val Ser Leu Arg 515 520 525 Gln Gly Met Arg Ala Asp Pro Gly Val Leu Ala Ala Leu Cys Glu Lys 530 535 540 Thr Asp Asn Asp Ile Arg Ala Cys Ile Asn Thr Leu Gln Phe Leu Tyr 545 550 555 560 Ser Arg Gly Gln Arg Glu Leu Ser Val Arg Asp Val Gln Ala Thr Arg 565 570 575 Val Gly Leu Lys Asp Gln Arg Arg Gly Leu Phe Ser Val Trp Gln Glu 580 585 590 Val Phe Gln Leu Pro Arg Ala Gln Arg Arg Arg Val Gly Gln Asp Pro 595 600 605 Ala Leu Pro Ala Asp Thr Leu Leu Leu Gly Asp Gly Asp Ala Gly Ser 610 615 620 Leu Thr Ser Ala Ser Gln Arg Phe Tyr Arg Val Leu His Ala Ala Ala 625 630 635 640 Ser Ala Gly Glu His Glu Lys Val Val Gln Gly Leu Phe Asp Asn Phe 645 650 655 Leu Arg Leu Arg Leu Arg Asp Ser Ser Leu Gly Ala Val Cys Val Ala 660 665 670 Leu Asp Trp Leu Ala Phe Asp Asp Leu Leu Ala Gly Ala Ala His His 675 680 685 Ser Gln Ser Phe Gln Leu Leu Arg Tyr Pro Pro Phe Leu Pro Val Ala 690 695 700 Phe His Val Leu Phe Ala Ser Ser His Thr Pro Arg Ile Thr Phe Pro 705 710 715 720 Ser Ser Gln Gln Glu Ala Gln Asn Arg Met Ser Gln Met Arg Asn Leu 725 730 735 Ile Gln Thr Leu Val Ser Gly Ile Ala Pro Ala Thr Arg Ser Arg Ala 740 745 750 Thr Pro Gln Ala Leu Leu Leu Asp Ala Leu Cys Leu Leu Leu Asp Ile 755 760 765 Leu Ala Pro Lys Leu Arg Pro Val Ser Thr Gln Leu Tyr Ser Thr Arg 770 775 780 Glu Lys Gln Gln Leu Ala Ser Leu Val Gly Thr Met Leu Ala Tyr Ser 785 790 795 800 Leu Thr Tyr Arg Gln Glu Arg Thr Pro Asp Gly Gln Tyr Ile Tyr Arg 805 810 815 Leu Glu Pro Asn Val Glu Glu Leu Cys Arg Phe Pro Glu Leu Pro Ala 820 825 830 Arg Lys Pro Leu Thr Tyr Gln Thr Lys Gln Leu Ile Ala Arg Glu Ile 835 840 845 Glu Val Glu Lys Met Arg Arg Ala Glu Ala Ser Ala Arg Val Glu Asn 850 855 860 Ser Pro Gln Val Asp Gly Ser Pro Pro Gly Leu Glu Gly Leu Leu Gly 865 870 875 880 Gly Ile Gly Glu Lys Gly Val His Arg Pro Ala Pro Arg Asn His Glu 885 890 895 Gln Arg Leu Glu His Ile Met Arg Arg Ala Ala Arg Glu Glu Gln Pro 900 905 910 Glu Lys Asp Phe Phe Gly Arg Val Val Val Arg Ser Thr Ala Val Pro 915 920 925 Ser Ala Gly Asp Thr Ala Pro Glu Gln Asp Ser Val Glu Arg Arg Met 930 935 940 Gly Thr Ala Val Gly Arg Ser Glu Val Trp Phe Arg Phe Asn Glu Gly 945 950 955 960 Val Ser Asn Ala Val Arg Arg Ser Leu Tyr Ile Arg Asp Leu Leu 965 970 975 <210> 673 <211> 631 <212> PRT <213> Homo sapiens <400> 673 Met Phe Tyr Ala His Phe Val Leu Ser Lys Arg Gly Pro Leu Ala Lys 1 5 10 15 Ile Trp Leu Ala Ala His Trp Asp Lys Lys Leu Thr Lys Ala His Val 20 25 30 Phe Glu Cys Asn Leu Glu Ser Ser Val Glu Ser Ile Ile Ser Pro Lys 35 40 45 Val Lys Met Ala Leu Arg Thr Ser Gly His Leu Leu Leu Gly Val Val 50 55 60 Arg Ile Tyr His Arg Lys Ala Lys Tyr Leu Leu Ala Asp Cys Asn Glu 65 70 75 80 Ala Phe Ile Lys Ile Lys Met Ala Phe Arg Pro Gly Val Val Asp Leu 85 90 95 Pro Glu Glu Asn Arg Glu Ala Ala Tyr Asn Ala Ile Thr Leu Pro Glu 100 105 110 Glu Phe His Asp Phe Asp Gln Pro Leu Pro Asp Leu Asp Asp Ile Asp 115 120 125 Val Ala Gln Gln Phe Ser Leu Asn Gln Ser Arg Val Glu Glu Ile Thr 130 135 140 Met Arg Glu Glu Val Gly Asn Ile Ser Ile Leu Gln Glu Asn Asp Phe 145 150 155 160 Gly Asp Phe Gly Met Asp Asp Arg Glu Ile Met Arg Glu Gly Ser Ala 165 170 175 Phe Glu Asp Asp Asp Met Leu Val Ser Thr Thr Thr Ser Asn Leu Leu 180 185 190 Leu Glu Ser Glu Gln Ser Thr Ser Asn Leu Asn Glu Lys Ile Asn His 195 200 205 Leu Glu Tyr Glu Asp Gln Tyr Lys Asp Asp Asn Phe Gly Glu Gly Asn 210 215 220 Asp Gly Gly Ile Leu Asp Asp Lys Leu Ile Ser Asn Asn Asp Gly Gly 225 230 235 240 Ile Phe Asp Asp Pro Pro Ala Leu Ser Glu Ala Gly Val Met Leu Pro 245 250 255 Glu Gln Pro Ala His Asp Asp Met Asp Glu Asp Asp Asn Val Ser Met 260 265 270 Gly Gly Pro Asp Ser Pro Asp Ser Val Asp Pro Val Glu Pro Met Pro 275 280 285 Thr Met Thr Asp Gln Thr Thr Leu Val Pro Asn Glu Glu Glu Ala Phe 290 295 300 Ala Leu Glu Pro Ile Asp Ile Thr Val Lys Glu Thr Lys Ala Lys Arg 305 310 315 320 Lys Arg Lys Leu Ile Val Asp Ser Val Lys Glu Leu Asp Ser Lys Thr 325 330 335 Ile Arg Ala Gln Leu Ser Asp Tyr Ser Asp Ile Val Thr Thr Leu Asp 340 345 350 Leu Ala Pro Pro Thr Lys Lys Leu Met Met Trp Lys Glu Thr Gly Gly 355 360 365 Val Glu Lys Leu Phe Ser Leu Pro Ala Gln Pro Leu Trp Asn Asn Arg 370 375 380 Leu Leu Lys Leu Phe Thr Arg Cys Leu Thr Pro Leu Val Pro Glu Asp 385 390 395 400 Leu Arg Lys Arg Arg Lys Gly Gly Glu Ala Asp Asn Leu Asp Glu Phe 405 410 415 Leu Lys Glu Phe Glu Asn Pro Glu Val Pro Arg Glu Asp Gln Gln Gln 420 425 430 Gln His Gln Gln Arg Asp Val Ile Asp Glu Pro Ile Ile Glu Glu Pro 435 440 445 Ser Arg Leu Gln Glu Ser Val Met Glu Ala Ser Arg Thr Asn Ile Asp 450 455 460 Glu Ser Ala Met Pro Pro Pro Pro Pro Gln Gly Val Lys Arg Lys Ala 465 470 475 480 Gly Gln Ile Asp Pro Glu Pro Val Met Pro Pro Gln Gln Val Glu Gln 485 490 495 Met Glu Ile Pro Pro Val Glu Leu Pro Pro Glu Glu Pro Pro Asn Ile 500 505 510 Cys Gln Leu Ile Pro Glu Leu Glu Leu Leu Pro Glu Lys Glu Lys Glu 515 520 525 Lys Glu Lys Glu Lys Glu Asp Asp Glu Glu Glu Glu Asp Glu Asp Ala 530 535 540 Ser Gly Gly Asp Gln Asp Gln Glu Glu Arg Arg Trp Asn Lys Arg Thr 545 550 555 560 Gln Gln Met Leu His Gly Leu Gln Arg Ala Leu Ala Lys Thr Gly Ala 565 570 575 Glu Ser Ile Ser Leu Leu Glu Leu Cys Arg Asn Thr Asn Arg Lys Gln 580 585 590 Ala Ala Ala Lys Phe Tyr Ser Phe Leu Val Leu Lys Lys Gln Gln Ala 595 600 605 Ile Glu Leu Thr Gln Glu Glu Pro Tyr Ser Asp Ile Ile Ala Thr Pro 610 615 620 Gly Pro Arg Phe His Ile Ile 625 630 <210> 674 <211> 1258 <212> PRT <213> Homo sapiens <400> 674 Met Ile Thr Ser Glu Leu Pro Val Leu Gln Asp Ser Thr Asn Glu Thr 1 5 10 15 Thr Ala His Ser Asp Ala Gly Ser Glu Leu Glu Glu Thr Glu Val Lys 20 25 30 Gly Lys Arg Lys Arg Gly Arg Pro Gly Arg Pro Pro Ser Thr Asn Lys 35 40 45 Lys Pro Arg Lys Ser Pro Gly Glu Lys Ser Arg Ile Glu Ala Gly Ile 50 55 60 Arg Gly Ala Gly Arg Gly Arg Ala Asn Gly His Pro Gln Gln Asn Gly 65 70 75 80 Glu Gly Glu Pro Val Thr Leu Phe Glu Val Val Lys Leu Gly Lys Ser 85 90 95 Ala Met Gln Ser Val Val Asp Asp Trp Ile Glu Ser Tyr Lys Gln Asp 100 105 110 Arg Asp Ile Ala Leu Leu Asp Leu Ile Asn Phe Phe Ile Gln Cys Ser 115 120 125 Gly Cys Arg Gly Thr Val Arg Ile Glu Met Phe Arg Asn Met Gln Asn 130 135 140 Ala Glu Ile Ile Arg Lys Met Thr Glu Glu Phe Asp Glu Asp Ser Gly 145 150 155 160 Asp Tyr Pro Leu Thr Met Pro Gly Pro Gln Trp Lys Lys Phe Arg Ser 165 170 175 Asn Phe Cys Glu Phe Ile Gly Val Leu Ile Arg Gln Cys Gln Tyr Ser 180 185 190 Ile Ile Tyr Asp Glu Tyr Met Met Asp Thr Val Ile Ser Leu Leu Thr 195 200 205 Gly Leu Ser Asp Ser Gln Val Arg Ala Phe Arg His Thr Ser Thr Leu 210 215 220 Ala Ala Met Lys Leu Met Thr Ala Leu Val Asn Val Ala Leu Asn Leu 225 230 235 240 Ser Ile His Gln Asp Asn Thr Gln Arg Gln Tyr Glu Ala Glu Arg Asn 245 250 255 Lys Met Ile Gly Lys Arg Ala Asn Glu Arg Leu Glu Leu Leu Leu Gln 260 265 270 Lys Arg Lys Glu Leu Gln Glu Asn Gln Asp Glu Ile Glu Asn Met Met 275 280 285 Asn Ser Ile Phe Lys Gly Ile Phe Val His Arg Tyr Arg Asp Ala Ile 290 295 300 Ala Glu Ile Arg Ala Ile Cys Ile Glu Glu Ile Gly Val Trp Met Lys 305 310 315 320 Met Tyr Ser Asp Ala Phe Leu Asn Asp Ser Tyr Leu Lys Tyr Val Gly 325 330 335 Trp Thr Leu His Asp Arg Gln Gly Glu Val Arg Leu Lys Cys Leu Lys 340 345 350 Ala Leu Gln Ser Leu Tyr Thr Asn Arg Glu Leu Phe Pro Lys Leu Glu 355 360 365 Leu Phe Thr Asn Arg Phe Lys Asp Arg Ile Val Ser Met Thr Leu Asp 370 375 380 Lys Glu Tyr Asp Val Ala Val Glu Ala Ile Arg Leu Val Thr Leu Ile 385 390 395 400 Leu His Gly Ser Glu Glu Ala Leu Ser Asn Glu Asp Cys Glu Asn Val 405 410 415 Tyr His Leu Val Tyr Ser Ala His Arg Pro Val Ala Val Ala Ala Gly 420 425 430 Glu Phe Leu His Lys Lys Leu Phe Ser Arg His Asp Pro Gln Ala Glu 435 440 445 Glu Ala Leu Ala Lys Arg Arg Gly Arg Asn Ser Pro Asn Gly Asn Leu 450 455 460 Ile Arg Met Leu Val Leu Phe Phe Leu Glu Ser Glu Leu His Glu His 465 470 475 480 Ala Ala Tyr Leu Val Asp Ser Leu Trp Glu Ser Ser Gln Glu Leu Leu 485 490 495 Lys Asp Trp Glu Cys Met Thr Glu Leu Leu Leu Glu Glu Pro Val Gln 500 505 510 Gly Glu Glu Ala Met Ser Asp Arg Gln Glu Ser Ala Leu Ile Glu Leu 515 520 525 Met Val Cys Thr Ile Arg Gln Ala Ala Glu Ala His Pro Pro Val Gly 530 535 540 Arg Gly Thr Gly Lys Arg Val Leu Thr Ala Lys Glu Arg Lys Thr Gln 545 550 555 560 Ile Asp Asp Arg Asn Lys Leu Thr Glu His Phe Ile Ile Thr Leu Pro 565 570 575 Met Leu Leu Ser Lys Tyr Ser Ala Asp Ala Glu Lys Val Ala Asn Leu 580 585 590 Leu Gln Ile Pro Gln Tyr Phe Asp Leu Glu Ile Tyr Ser Thr Gly Arg 595 600 605 Met Glu Lys His Leu Asp Ala Leu Leu Lys Gln Ile Lys Phe Val Val 610 615 620 Glu Lys His Val Glu Ser Asp Val Leu Glu Ala Cys Ser Lys Thr Tyr 625 630 635 640 Ser Ile Leu Cys Asn Glu Glu Tyr Thr Ile Gln Asn Arg Val Asp Ile 645 650 655 Ala Arg Ser Gln Leu Ile Asp Glu Phe Val Asp Arg Phe Asn His Ser 660 665 670 Val Glu Asp Leu Leu Gln Glu Gly Glu Glu Ala Asp Asp Asp Asp Ile 675 680 685 Tyr Asn Val Leu Ser Thr Leu Lys Arg Leu Thr Ser Phe Gln Asn Ala 690 695 700 His Asp Leu Thr Lys Trp Asp Leu Phe Gly Asn Cys Tyr Arg Leu Leu 705 710 715 720 Lys Thr Gly Ile Glu His Gly Ala Met Pro Glu Gln Ile Val Val Gln 725 730 735 Ala Leu Gln Cys Ser His Tyr Ser Ile Leu Trp Gln Leu Val Lys Ile 740 745 750 Thr Asp Gly Ser Pro Ser Lys Glu Asp Leu Leu Val Leu Arg Lys Thr 755 760 765 Val Lys Ser Phe Leu Ala Val Cys Gln Gln Cys Leu Ser Asn Val Asn 770 775 780 Thr Pro Val Lys Glu Gln Ala Phe Met Leu Leu Cys Asp Leu Leu Met 785 790 795 800 Ile Phe Ser His Gln Leu Met Thr Gly Gly Arg Glu Gly Leu Gln Pro 805 810 815 Leu Val Phe Asn Pro Asp Thr Gly Leu Gln Ser Glu Leu Leu Ser Phe 820 825 830 Val Met Asp His Val Phe Ile Asp Gln Asp Glu Glu Asn Gln Ser Met 835 840 845 Glu Gly Asp Glu Glu Asp Glu Ala Asn Lys Ile Glu Ala Leu His Lys 850 855 860 Arg Arg Asn Leu Leu Ala Ala Phe Ser Lys Leu Ile Ile Tyr Asp Ile 865 870 875 880 Val Asp Met His Ala Ala Ala Asp Ile Phe Lys His Tyr Met Lys Tyr 885 890 895 Tyr Asn Asp Tyr Gly Asp Ile Ile Lys Glu Thr Leu Ser Lys Thr Arg 900 905 910 Gln Ile Asp Lys Ile Gln Cys Ala Lys Thr Leu Ile Leu Ser Leu Gln 915 920 925 Gln Leu Phe Asn Glu Leu Val Gln Glu Gln Gly Pro Asn Leu Asp Arg 930 935 940 Thr Ser Ala His Val Ser Gly Ile Lys Glu Leu Ala Arg Arg Phe Ala 945 950 955 960 Leu Thr Phe Gly Leu Asp Gln Ile Lys Thr Arg Glu Ala Val Ala Thr 965 970 975 Leu His Lys Asp Gly Ile Glu Phe Ala Phe Lys Tyr Gln Asn Gln Lys 980 985 990 Gly Gln Glu Tyr Pro Pro Pro Asn Leu Ala Phe Leu Glu Val Leu Ser 995 1000 1005 Glu Phe Ser Ser Lys Leu Leu Arg Gln Asp Lys Lys Thr Val His 1010 1015 1020 Ser Tyr Leu Glu Lys Phe Leu Thr Glu Gln Met Met Glu Arg Arg 1025 1030 1035 Glu Asp Val Trp Leu Pro Leu Ile Ser Tyr Arg Asn Ser Leu Val 1040 1045 1050 Thr Gly Gly Glu Asp Asp Arg Met Ser Val Asn Ser Gly Ser Ser 1055 1060 1065 Ser Ser Lys Thr Ser Ser Val Arg Asn Lys Lys Gly Arg Pro Pro 1070 1075 1080 Leu His Lys Lys Arg Val Glu Asp Glu Ser Leu Asp Asn Thr Trp 1085 1090 1095 Leu Asn Arg Thr Asp Thr Met Ile Gln Thr Pro Gly Pro Leu Pro 1100 1105 1110 Ala Pro Gln Leu Thr Ser Thr Val Leu Arg Glu Asn Ser Arg Pro 1115 1120 1125 Met Gly Asp Gln Ile Gln Glu Pro Glu Ser Glu His Gly Ser Glu 1130 1135 1140 Pro Asp Phe Leu His Asn Pro Gln Met Gln Ile Ser Trp Leu Gly 1145 1150 1155 Gln Pro Lys Leu Glu Asp Leu Asn Arg Lys Asp Arg Thr Gly Met 1160 1165 1170 Asn Tyr Met Lys Val Arg Thr Gly Val Arg His Ala Val Arg Gly 1175 1180 1185 Leu Met Glu Glu Asp Ala Glu Pro Ile Phe Glu Asp Val Met Met 1190 1195 1200 Ser Ser Arg Ser Gln Leu Glu Asp Met Asn Glu Glu Phe Glu Asp 1205 1210 1215 Thr Met Val Ile Asp Leu Pro Pro Ser Arg Asn Arg Arg Glu Arg 1220 1225 1230 Ala Glu Leu Arg Pro Asp Phe Phe Asp Ser Ala Ala Ile Ile Glu 1235 1240 1245 Asp Asp Ser Gly Phe Gly Met Pro Met Phe 1250 1255 <210> 675 <211> 2644 <212> PRT <213> Homo sapiens <400> 675 Met Gly Glu His Gly Leu Glu Leu Ala Ser Met Ile Pro Ala Leu Arg 1 5 10 15 Glu Leu Gly Ser Ala Thr Pro Glu Glu Tyr Asn Thr Val Val Gln Lys 20 25 30 Pro Arg Gln Ile Leu Cys Gln Phe Ile Asp Arg Ile Leu Thr Asp Val 35 40 45 Asn Val Val Ala Val Glu Leu Val Lys Lys Thr Asp Ser Gln Pro Thr 50 55 60 Ser Val Met Leu Leu Asp Phe Ile Gln His Ile Met Lys Ser Ser Pro 65 70 75 80 Leu Met Phe Val Asn Val Ser Gly Ser His Glu Arg Lys Gly Ser Cys 85 90 95 Ile Glu Phe Ser Asn Trp Ile Ile Thr Arg Leu Leu Arg Ile Ala Ala 100 105 110 Thr Pro Ser Cys His Leu Leu His Lys Lys Ile Cys Glu Val Ile Cys 115 120 125 Ser Leu Leu Phe Leu Phe Lys Ser Lys Ser Pro Ala Ile Phe Gly Val 130 135 140 Leu Thr Lys Glu Leu Leu Gln Leu Phe Glu Asp Leu Val Tyr Leu His 145 150 155 160 Arg Arg Asn Val Met Gly His Ala Val Glu Trp Pro Val Val Met Ser 165 170 175 Arg Phe Leu Ser Gln Leu Asp Glu His Met Gly Tyr Leu Gln Ser Ala 180 185 190 Pro Leu Gln Leu Met Ser Met Gln Asn Leu Glu Phe Ile Glu Val Thr 195 200 205 Leu Leu Met Val Leu Thr Arg Ile Ile Ala Ile Val Phe Phe Arg Arg 210 215 220 Gln Glu Leu Leu Leu Trp Gln Ile Gly Cys Val Leu Leu Glu Tyr Gly 225 230 235 240 Ser Pro Lys Ile Lys Ser Leu Ala Ile Ser Phe Leu Thr Glu Leu Phe 245 250 255 Gln Leu Gly Gly Leu Pro Ala Gln Pro Ala Ser Thr Phe Phe Ser Ser 260 265 270 Phe Leu Glu Leu Leu Lys His Leu Val Glu Met Asp Thr Asp Gln Leu 275 280 285 Lys Leu Tyr Glu Glu Pro Leu Ser Lys Leu Ile Lys Thr Leu Phe Pro 290 295 300 Phe Glu Ala Glu Ala Tyr Arg Asn Ile Glu Pro Val Tyr Leu Asn Met 305 310 315 320 Leu Leu Glu Lys Leu Cys Val Met Phe Glu Asp Gly Val Leu Met Arg 325 330 335 Leu Lys Ser Asp Leu Leu Lys Ala Ala Leu Cys His Leu Leu Gln Tyr 340 345 350 Phe Leu Lys Phe Val Pro Ala Gly Tyr Glu Ser Ala Leu Gln Val Arg 355 360 365 Lys Val Tyr Val Arg Asn Ile Cys Lys Ala Leu Leu Asp Val Leu Gly 370 375 380 Ile Glu Val Asp Ala Glu Tyr Leu Leu Gly Pro Leu Tyr Ala Ala Leu 385 390 395 400 Lys Met Glu Ser Met Glu Ile Ile Glu Glu Ile Gln Cys Gln Thr Gln 405 410 415 Gln Glu Asn Leu Ser Ser Asn Ser Asp Gly Ile Ser Pro Lys Arg Arg 420 425 430 Arg Leu Ser Ser Ser Leu Asn Pro Ser Lys Arg Ala Pro Lys Gln Thr 435 440 445 Glu Glu Ile Lys His Val Asp Met Asn Gln Lys Ser Ile Leu Trp Ser 450 455 460 Ala Leu Lys Gln Lys Ala Glu Ser Leu Gln Ile Ser Leu Glu Tyr Ser 465 470 475 480 Gly Leu Lys Asn Pro Val Ile Glu Met Leu Glu Gly Ile Ala Val Val 485 490 495 Leu Gln Leu Thr Ala Leu Cys Thr Val His Cys Ser His Gln Asn Met 500 505 510 Asn Cys Arg Thr Phe Lys Asp Cys Gln His Lys Ser Lys Lys Lys Pro 515 520 525 Ser Val Val Ile Thr Trp Met Ser Leu Asp Phe Tyr Thr Lys Val Leu 530 535 540 Lys Ser Cys Arg Ser Leu Leu Glu Ser Val Gln Lys Leu Asp Leu Glu 545 550 555 560 Ala Thr Ile Asp Lys Val Val Lys Ile Tyr Asp Ala Leu Ile Tyr Met 565 570 575 Gln Val Asn Ser Ser Phe Glu Asp His Ile Leu Glu Asp Leu Cys Gly 580 585 590 Met Leu Ser Leu Pro Trp Ile Tyr Ser His Ser Asp Asp Gly Cys Leu 595 600 605 Lys Leu Thr Thr Phe Ala Ala Asn Leu Leu Thr Leu Ser Cys Arg Ile 610 615 620 Ser Asp Ser Tyr Ser Pro Gln Ala Gln Ser Arg Cys Val Phe Leu Leu 625 630 635 640 Thr Leu Phe Pro Arg Arg Ile Phe Leu Glu Trp Arg Thr Ala Val Tyr 645 650 655 Asn Trp Ala Leu Gln Ser Ser His Glu Val Ile Arg Ala Ser Cys Val 660 665 670 Ser Gly Phe Phe Ile Leu Leu Gln Gln Gln Asn Ser Cys Asn Arg Val 675 680 685 Pro Lys Ile Leu Ile Asp Lys Val Lys Asp Asp Ser Asp Ile Val Lys 690 695 700 Lys Glu Phe Ala Ser Ile Leu Gly Gln Leu Val Cys Thr Leu His Gly 705 710 715 720 Met Phe Tyr Leu Thr Ser Ser Leu Thr Glu Pro Phe Ser Glu His Gly 725 730 735 His Val Asp Leu Phe Cys Arg Asn Leu Lys Ala Thr Ser Gln His Glu 740 745 750 Cys Ser Ser Ser Gln Leu Lys Ala Ser Val Cys Lys Pro Phe Leu Phe 755 760 765 Leu Leu Lys Lys Lys Ile Pro Ser Pro Val Lys Leu Ala Phe Ile Asp 770 775 780 Asn Leu His His Leu Cys Lys His Leu Asp Phe Arg Glu Asp Glu Thr 785 790 795 800 Asp Val Lys Ala Val Leu Gly Thr Leu Leu Asn Leu Met Glu Asp Pro 805 810 815 Asp Lys Asp Val Arg Val Ala Phe Ser Gly Asn Ile Lys His Ile Leu 820 825 830 Glu Ser Leu Asp Ser Glu Asp Gly Phe Ile Lys Glu Leu Phe Val Leu 835 840 845 Arg Met Lys Glu Ala Tyr Thr His Ala Gln Ile Ser Arg Asn Asn Glu 850 855 860 Leu Lys Asp Thr Leu Ile Leu Thr Thr Gly Asp Ile Gly Arg Ala Ala 865 870 875 880 Lys Gly Asp Leu Val Pro Phe Ala Leu Leu His Leu Leu His Cys Leu 885 890 895 Leu Ser Lys Ser Ala Ser Val Ser Gly Ala Ala Tyr Thr Glu Ile Arg 900 905 910 Ala Leu Val Ala Ala Lys Ser Val Lys Leu Gln Ser Phe Phe Ser Gln 915 920 925 Tyr Lys Lys Pro Ile Cys Gln Phe Leu Val Glu Ser Leu His Ser Ser 930 935 940 Gln Met Thr Ala Leu Pro Asn Thr Pro Cys Gln Asn Ala Asp Val Arg 945 950 955 960 Lys Gln Asp Val Ala His Gln Arg Glu Met Ala Leu Asn Thr Leu Ser 965 970 975 Glu Ile Ala Asn Val Phe Asp Phe Pro Asp Leu Asn Arg Phe Leu Thr 980 985 990 Arg Thr Leu Gln Val Leu Leu Pro Asp Leu Ala Ala Lys Ala Ser Pro 995 1000 1005 Ala Ala Ser Ala Leu Ile Arg Thr Leu Gly Lys Gln Leu Asn Val 1010 1015 1020 Asn Arg Arg Glu Ile Leu Ile Asn Asn Phe Lys Tyr Ile Phe Ser 1025 1030 1035 His Leu Val Cys Ser Cys Ser Lys Asp Glu Leu Glu Arg Ala Leu 1040 1045 1050 His Tyr Leu Lys Asn Glu Thr Glu Ile Glu Leu Gly Ser Leu Leu 1055 1060 1065 Arg Gln Asp Phe Gln Gly Leu His Asn Glu Leu Leu Leu Arg Ile 1070 1075 1080 Gly Glu His Tyr Gln Gln Val Phe Asn Gly Leu Ser Ile Leu Ala 1085 1090 1095 Ser Phe Ala Ser Ser Asp Asp Pro Tyr Gln Gly Pro Arg Asp Ile 1100 1105 1110 Ile Ser Pro Glu Leu Met Ala Asp Tyr Leu Gln Pro Lys Leu Leu 1115 1120 1125 Gly Ile Leu Ala Phe Phe Asn Met Gln Leu Leu Ser Ser Ser Val 1130 1135 1140 Gly Ile Glu Asp Lys Lys Met Ala Leu Asn Ser Leu Met Ser Leu 1145 1150 1155 Met Lys Leu Met Gly Pro Lys His Val Ser Ser Val Arg Val Lys 1160 1165 1170 Met Met Thr Thr Leu Arg Thr Gly Leu Arg Phe Lys Asp Asp Phe 1175 1180 1185 Pro Glu Leu Cys Cys Arg Ala Trp Asp Cys Phe Val Arg Cys Leu 1190 1195 1200 Asp His Ala Cys Leu Gly Ser Leu Leu Ser His Val Ile Val Ala 1205 1210 1215 Leu Leu Pro Leu Ile His Ile Gln Pro Lys Glu Thr Ala Ala Ile 1220 1225 1230 Phe His Tyr Leu Ile Ile Glu Asn Arg Asp Ala Val Gln Asp Phe 1235 1240 1245 Leu His Glu Ile Tyr Phe Leu Pro Asp His Pro Glu Leu Lys Lys 1250 1255 1260 Ile Lys Ala Val Leu Gln Glu Tyr Arg Lys Glu Thr Ser Glu Ser 1265 1270 1275 Thr Asp Leu Gln Thr Thr Leu Gln Leu Ser Met Lys Ala Ile Gln 1280 1285 1290 His Glu Asn Val Asp Val Arg Ile His Ala Leu Thr Ser Leu Lys 1295 1300 1305 Glu Thr Leu Tyr Lys Asn Gln Glu Lys Leu Ile Lys Tyr Ala Thr 1310 1315 1320 Asp Ser Glu Thr Val Glu Pro Ile Ile Ser Gln Leu Val Thr Val 1325 1330 1335 Leu Leu Lys Gly Cys Gln Asp Ala Asn Ser Gln Ala Arg Leu Leu 1340 1345 1350 Cys Gly Glu Cys Leu Gly Glu Leu Gly Ala Ile Asp Pro Gly Arg 1355 1360 1365 Leu Asp Phe Ser Thr Thr Glu Thr Gln Gly Lys Asp Phe Thr Phe 1370 1375 1380 Val Thr Gly Val Glu Asp Ser Ser Phe Ala Tyr Gly Leu Leu Met 1385 1390 1395 Glu Leu Thr Arg Ala Tyr Leu Ala Tyr Ala Asp Asn Ser Arg Ala 1400 1405 1410 Gln Asp Ser Ala Ala Tyr Ala Ile Gln Glu Leu Leu Ser Ile Tyr 1415 1420 1425 Asp Cys Arg Glu Met Glu Thr Asn Gly Pro Gly His Gln Leu Trp 1430 1435 1440 Arg Arg Phe Pro Glu His Val Arg Glu Ile Leu Glu Pro His Leu 1445 1450 1455 Asn Thr Arg Tyr Lys Ser Ser Gln Lys Ser Thr Asp Trp Ser Gly 1460 1465 1470 Val Lys Lys Pro Ile Tyr Leu Ser Lys Leu Gly Ser Asn Phe Ala 1475 1480 1485 Glu Trp Ser Ala Ser Trp Ala Gly Tyr Leu Ile Thr Lys Val Arg 1490 1495 1500 His Asp Leu Ala Ser Lys Ile Phe Thr Cys Cys Ser Ile Met Met 1505 1510 1515 Lys His Asp Phe Lys Val Thr Ile Tyr Leu Leu Pro His Ile Leu 1520 1525 1530 Val Tyr Val Leu Leu Gly Cys Asn Gln Glu Asp Gln Gln Glu Val 1535 1540 1545 Tyr Ala Glu Ile Met Ala Val Leu Lys His Asp Asp Gln His Thr 1550 1555 1560 Ile Asn Thr Gln Asp Ile Ala Ser Asp Leu Cys Gln Leu Ser Thr 1565 1570 1575 Gln Thr Val Phe Ser Met Leu Asp His Leu Thr Gln Trp Ala Arg 1580 1585 1590 His Lys Phe Gln Ala Leu Lys Ala Glu Lys Cys Pro His Ser Lys 1595 1600 1605 Ser Asn Arg Asn Lys Val Asp Ser Met Val Ser Thr Val Asp Tyr 1610 1615 1620 Glu Asp Tyr Gln Ser Val Thr Arg Phe Leu Asp Leu Ile Pro Gln 1625 1630 1635 Asp Thr Leu Ala Val Ala Ser Phe Arg Ser Lys Ala Tyr Thr Arg 1640 1645 1650 Ala Val Met His Phe Glu Ser Phe Ile Thr Glu Lys Lys Gln Asn 1655 1660 1665 Ile Gln Glu His Leu Gly Phe Leu Gln Lys Leu Tyr Ala Ala Met 1670 1675 1680 His Glu Pro Asp Gly Val Ala Gly Val Ser Ala Ile Arg Lys Ala 1685 1690 1695 Glu Pro Ser Leu Lys Glu Gln Ile Leu Glu His Glu Ser Leu Gly 1700 1705 1710 Leu Leu Arg Asp Ala Thr Ala Cys Tyr Asp Arg Ala Ile Gln Leu 1715 1720 1725 Glu Pro Asp Gln Ile Ile His Tyr His Gly Val Val Lys Ser Met 1730 1735 1740 Leu Gly Leu Gly Gln Leu Ser Thr Val Ile Thr Gln Val Asn Gly 1745 1750 1755 Val His Ala Asn Arg Ser Glu Trp Thr Asp Glu Leu Asn Thr Tyr 1760 1765 1770 Arg Val Glu Ala Ala Trp Lys Leu Ser Gln Trp Asp Leu Val Glu 1775 1780 1785 Asn Tyr Leu Ala Ala Asp Gly Lys Ser Thr Thr Trp Ser Val Arg 1790 1795 1800 Leu Gly Gln Leu Leu Leu Ser Ala Lys Lys Arg Asp Ile Thr Ala 1805 1810 1815 Phe Tyr Asp Ser Leu Lys Leu Val Arg Ala Glu Gln Ile Val Pro 1820 1825 1830 Leu Ser Ala Ala Ser Phe Glu Arg Gly Ser Tyr Gln Arg Gly Tyr 1835 1840 1845 Glu Tyr Ile Val Arg Leu His Met Leu Cys Glu Leu Glu His Ser 1850 1855 1860 Ile Lys Pro Leu Phe Gln His Ser Pro Gly Asp Ser Ser Gln Glu 1865 1870 1875 Asp Ser Leu Asn Trp Val Ala Arg Leu Glu Met Thr Gln Asn Ser 1880 1885 1890 Tyr Arg Ala Lys Glu Pro Ile Leu Ala Leu Arg Arg Ala Leu Leu 1895 1900 1905 Ser Leu Asn Lys Arg Pro Asp Tyr Asn Glu Met Val Gly Glu Cys 1910 1915 1920 Trp Leu Gln Ser Ala Arg Val Ala Arg Lys Ala Gly His His Gln 1925 1930 1935 Thr Ala Tyr Asn Ala Leu Leu Asn Ala Gly Glu Ser Arg Leu Ala 1940 1945 1950 Glu Leu Tyr Val Glu Arg Ala Lys Trp Leu Trp Ser Lys Gly Asp 1955 1960 1965 Val His Gln Ala Leu Ile Val Leu Gln Lys Gly Val Glu Leu Cys 1970 1975 1980 Phe Pro Glu Asn Glu Thr Pro Pro Glu Gly Lys Asn Met Leu Ile 1985 1990 1995 His Gly Arg Ala Met Leu Leu Val Gly Arg Phe Met Glu Glu Thr 2000 2005 2010 Ala Asn Phe Glu Ser Asn Ala Ile Met Lys Lys Tyr Lys Asp Val 2015 2020 2025 Thr Ala Cys Leu Pro Glu Trp Glu Asp Gly His Phe Tyr Leu Ala 2030 2035 2040 Lys Tyr Tyr Asp Lys Leu Met Pro Met Val Thr Asp Asn Lys Met 2045 2050 2055 Glu Lys Gln Gly Asp Leu Ile Arg Tyr Ile Val Leu His Phe Gly 2060 2065 2070 Arg Ser Leu Gln Tyr Gly Asn Gln Phe Ile Tyr Gln Ser Met Pro 2075 2080 2085 Arg Met Leu Thr Leu Trp Leu Asp Tyr Gly Thr Lys Ala Tyr Glu 2090 2095 2100 Trp Glu Lys Ala Gly Arg Ser Asp Arg Val Gln Met Arg Asn Asp 2105 2110 2115 Leu Gly Lys Ile Asn Lys Val Ile Thr Glu His Thr Asn Tyr Leu 2120 2125 2130 Ala Pro Tyr Gln Phe Leu Thr Ala Phe Ser Gln Leu Ile Ser Arg 2135 2140 2145 Ile Cys His Ser His Asp Glu Val Phe Val Val Leu Met Glu Ile 2150 2155 2160 Ile Ala Lys Val Phe Leu Ala Tyr Pro Gln Gln Ala Met Trp Met 2165 2170 2175 Met Thr Ala Val Ser Lys Ser Ser Tyr Pro Met Arg Val Asn Arg 2180 2185 2190 Cys Lys Glu Ile Leu Asn Lys Ala Ile His Met Lys Lys Ser Leu 2195 2200 2205 Glu Lys Phe Val Gly Asp Ala Thr Arg Leu Thr Asp Lys Leu Leu 2210 2215 2220 Glu Leu Cys Asn Lys Pro Val Asp Gly Ser Ser Ser Thr Leu Ser 2225 2230 2235 Met Ser Thr His Phe Lys Met Leu Lys Lys Leu Val Glu Glu Ala 2240 2245 2250 Thr Phe Ser Glu Ile Leu Ile Pro Leu Gln Ser Val Met Ile Pro 2255 2260 2265 Thr Leu Pro Ser Ile Leu Gly Thr His Ala Asn His Ala Ser His 2270 2275 2280 Glu Pro Phe Pro Gly His Trp Ala Tyr Ile Ala Gly Phe Asp Asp 2285 2290 2295 Met Val Glu Ile Leu Ala Ser Leu Gln Lys Pro Lys Lys Ile Ser 2300 2305 2310 Leu Lys Gly Ser Asp Gly Lys Phe Tyr Ile Met Met Cys Lys Pro 2315 2320 2325 Lys Asp Asp Leu Arg Lys Asp Cys Arg Leu Met Glu Phe Asn Ser 2330 2335 2340 Leu Ile Asn Lys Cys Leu Arg Lys Asp Ala Glu Ser Arg Arg Arg 2345 2350 2355 Glu Leu His Ile Arg Thr Tyr Ala Val Ile Pro Leu Asn Asp Glu 2360 2365 2370 Cys Gly Ile Ile Glu Trp Val Asn Asn Thr Ala Gly Leu Arg Pro 2375 2380 2385 Ile Leu Thr Lys Leu Tyr Lys Glu Lys Gly Val Tyr Met Thr Gly 2390 2395 2400 Lys Glu Leu Arg Gln Cys Met Leu Pro Lys Ser Ala Ala Leu Ser 2405 2410 2415 Glu Lys Leu Lys Val Phe Arg Glu Phe Leu Leu Pro Arg His Pro 2420 2425 2430 Pro Ile Phe His Glu Trp Phe Leu Arg Thr Phe Pro Asp Pro Thr 2435 2440 2445 Ser Trp Tyr Ser Ser Arg Ser Ala Tyr Cys Arg Ser Thr Ala Val 2450 2455 2460 Met Ser Met Val Gly Tyr Ile Leu Gly Leu Gly Asp Arg His Gly 2465 2470 2475 Glu Asn Ile Leu Phe Asp Ser Leu Thr Gly Glu Cys Val His Val 2480 2485 2490 Asp Phe Asn Cys Leu Phe Asn Lys Gly Glu Thr Phe Glu Val Pro 2495 2500 2505 Glu Ile Val Pro Phe Arg Leu Thr His Asn Met Val Asn Gly Met 2510 2515 2520 Gly Pro Met Gly Thr Glu Gly Leu Phe Arg Arg Ala Cys Glu Val 2525 2530 2535 Thr Met Arg Leu Met Arg Asp Gln Arg Glu Pro Leu Met Ser Val 2540 2545 2550 Leu Lys Thr Phe Leu His Asp Pro Leu Val Glu Trp Ser Lys Pro 2555 2560 2565 Val Lys Gly His Ser Lys Ala Pro Leu Asn Glu Thr Gly Glu Val 2570 2575 2580 Val Asn Glu Lys Ala Lys Thr His Val Leu Asp Ile Glu Gln Arg 2585 2590 2595 Leu Gln Gly Val Ile Lys Thr Arg Asn Arg Val Thr Gly Leu Pro 2600 2605 2610 Leu Ser Ile Glu Gly His Val His Tyr Leu Ile Gln Glu Ala Thr 2615 2620 2625 Asp Glu Asn Leu Leu Cys Gln Met Tyr Leu Gly Trp Thr Pro Tyr 2630 2635 2640 Met <210> 676 <211> 476 <212> PRT <213> Homo sapiens <400> 676 Met Ala Val Pro Phe Val Glu Asp Trp Asp Leu Val Gln Thr Leu Gly 1 5 10 15 Glu Gly Ala Tyr Gly Glu Val Gln Leu Ala Val Asn Arg Val Thr Glu 20 25 30 Glu Ala Val Ala Val Lys Ile Val Asp Met Lys Arg Ala Val Asp Cys 35 40 45 Pro Glu Asn Ile Lys Lys Glu Ile Cys Ile Asn Lys Met Leu Asn His 50 55 60 Glu Asn Val Val Lys Phe Tyr Gly His Arg Arg Glu Gly Asn Ile Gln 65 70 75 80 Tyr Leu Phe Leu Glu Tyr Cys Ser Gly Gly Glu Leu Phe Asp Arg Ile 85 90 95 Glu Pro Asp Ile Gly Met Pro Glu Pro Asp Ala Gln Arg Phe Phe His 100 105 110 Gln Leu Met Ala Gly Val Val Tyr Leu His Gly Ile Gly Ile Thr His 115 120 125 Arg Asp Ile Lys Pro Glu Asn Leu Leu Leu Asp Glu Arg Asp Asn Leu 130 135 140 Lys Ile Ser Asp Phe Gly Leu Ala Thr Val Phe Arg Tyr Asn Asn Arg 145 150 155 160 Glu Arg Leu Leu Asn Lys Met Cys Gly Thr Leu Pro Tyr Val Ala Pro 165 170 175 Glu Leu Leu Lys Arg Arg Glu Phe His Ala Glu Pro Val Asp Val Trp 180 185 190 Ser Cys Gly Ile Val Leu Thr Ala Met Leu Ala Gly Glu Leu Pro Trp 195 200 205 Asp Gln Pro Ser Asp Ser Cys Gln Glu Tyr Ser Asp Trp Lys Glu Lys 210 215 220 Lys Thr Tyr Leu Asn Pro Trp Lys Lys Ile Asp Ser Ala Pro Leu Ala 225 230 235 240 Leu Leu His Lys Ile Leu Val Glu Asn Pro Ser Ala Arg Ile Thr Ile 245 250 255 Pro Asp Ile Lys Lys Asp Arg Trp Tyr Asn Lys Pro Leu Lys Lys Gly 260 265 270 Ala Lys Arg Pro Arg Val Thr Ser Gly Gly Val Ser Glu Ser Pro Ser 275 280 285 Gly Phe Ser Lys His Ile Gln Ser Asn Leu Asp Phe Ser Pro Val Asn 290 295 300 Ser Ala Ser Ser Glu Glu Asn Val Lys Tyr Ser Ser Ser Gln Pro Glu 305 310 315 320 Pro Arg Thr Gly Leu Ser Leu Trp Asp Thr Ser Pro Ser Tyr Ile Asp 325 330 335 Lys Leu Val Gln Gly Ile Ser Phe Ser Gln Pro Thr Cys Pro Asp His 340 345 350 Met Leu Leu Asn Ser Gln Leu Leu Gly Thr Pro Gly Ser Ser Gln Asn 355 360 365 Pro Trp Gln Arg Leu Val Lys Arg Met Thr Arg Phe Phe Thr Lys Leu 370 375 380 Asp Ala Asp Lys Ser Tyr Gln Cys Leu Lys Glu Thr Cys Glu Lys Leu 385 390 395 400 Gly Tyr Gln Trp Lys Lys Ser Cys Met Asn Gln Val Thr Ile Ser Thr 405 410 415 Thr Asp Arg Arg Asn Asn Lys Leu Ile Phe Lys Val Asn Leu Leu Glu 420 425 430 Met Asp Asp Lys Ile Leu Val Asp Phe Arg Leu Ser Lys Gly Asp Gly 435 440 445 Leu Glu Phe Lys Arg His Phe Leu Lys Ile Lys Gly Lys Leu Ile Asp 450 455 460 Ile Val Ser Ser Gln Lys Val Trp Leu Pro Ala Thr 465 470 475 <210> 677 <211> 754 <212> PRT <213> Homo sapiens <400> 677 Met Trp Lys Leu Leu Pro Ala Ala Gly Pro Ala Gly Gly Glu Pro Tyr 1 5 10 15 Arg Leu Leu Thr Gly Val Glu Tyr Val Val Gly Arg Lys Asn Cys Ala 20 25 30 Ile Leu Ile Glu Asn Asp Gln Ser Ile Ser Arg Asn His Ala Val Leu 35 40 45 Thr Ala Asn Phe Ser Val Thr Asn Leu Ser Gln Thr Asp Glu Ile Pro 50 55 60 Val Leu Thr Leu Lys Asp Asn Ser Lys Tyr Gly Thr Phe Val Asn Glu 65 70 75 80 Glu Lys Met Gln Asn Gly Phe Ser Arg Thr Leu Lys Ser Gly Asp Gly 85 90 95 Ile Thr Phe Gly Val Phe Gly Ser Lys Phe Arg Ile Glu Tyr Glu Pro 100 105 110 Leu Val Ala Cys Ser Ser Cys Leu Asp Val Ser Gly Lys Thr Ala Leu 115 120 125 Asn Gln Ala Ile Leu Gln Leu Gly Gly Phe Thr Val Asn Asn Trp Thr 130 135 140 Glu Glu Cys Thr His Leu Val Met Val Ser Val Lys Val Thr Ile Lys 145 150 155 160 Thr Ile Cys Ala Leu Ile Cys Gly Arg Pro Ile Val Lys Pro Glu Tyr 165 170 175 Phe Thr Glu Phe Leu Lys Ala Val Glu Ser Lys Lys Gln Pro Pro Gln 180 185 190 Ile Glu Ser Phe Tyr Pro Pro Leu Asp Glu Pro Ser Ile Gly Ser Lys 195 200 205 Asn Val Asp Leu Ser Gly Arg Gln Glu Arg Lys Gln Ile Phe Lys Gly 210 215 220 Lys Thr Phe Ile Phe Leu Asn Ala Lys Gln His Lys Lys Leu Ser Ser 225 230 235 240 Ala Val Val Phe Gly Gly Gly Glu Ala Arg Leu Ile Thr Glu Glu Asn 245 250 255 Glu Glu Glu His Asn Phe Phe Leu Ala Pro Gly Thr Cys Val Val Asp 260 265 270 Thr Gly Ile Thr Asn Ser Gln Thr Leu Ile Pro Asp Cys Gln Lys Lys 275 280 285 Trp Ile Gln Ser Ile Met Asp Met Leu Gln Arg Gln Gly Leu Arg Pro 290 295 300 Ile Pro Glu Ala Glu Ile Gly Leu Ala Val Ile Phe Met Thr Thr Lys 305 310 315 320 Asn Tyr Cys Asp Pro Gln Gly His Pro Ser Thr Gly Leu Lys Thr Thr 325 330 335 Thr Pro Gly Pro Ser Leu Ser Gln Gly Val Ser Val Asp Glu Lys Leu 340 345 350 Met Pro Ser Ala Pro Val Asn Thr Thr Thr Tyr Val Ala Asp Thr Glu 355 360 365 Ser Glu Gln Ala Asp Thr Trp Asp Leu Ser Glu Arg Pro Lys Glu Ile 370 375 380 Lys Val Ser Lys Met Glu Gln Lys Phe Arg Met Leu Ser Gln Asp Ala 385 390 395 400 Pro Thr Val Lys Glu Ser Cys Lys Thr Ser Ser Asn Asn Asn Ser Met 405 410 415 Val Ser Asn Thr Leu Ala Lys Met Arg Ile Pro Asn Tyr Gln Leu Ser 420 425 430 Pro Thr Lys Leu Pro Ser Ile Asn Lys Ser Lys Asp Arg Ala Ser Gln 435 440 445 Gln Gln Gln Thr Asn Ser Ile Arg Asn Tyr Phe Gln Pro Ser Thr Lys 450 455 460 Lys Arg Glu Arg Asp Glu Glu Asn Gln Glu Met Ser Ser Cys Lys Ser 465 470 475 480 Ala Arg Ile Glu Thr Ser Cys Ser Leu Leu Glu Gln Thr Gln Pro Ala 485 490 495 Thr Pro Ser Leu Trp Lys Asn Lys Glu Gln His Leu Ser Glu Asn Glu 500 505 510 Pro Val Asp Thr Asn Ser Asp Asn Asn Leu Phe Thr Asp Thr Asp Leu 515 520 525 Lys Ser Ile Val Lys Asn Ser Ala Ser Lys Ser His Ala Ala Glu Lys 530 535 540 Leu Arg Ser Asn Lys Lys Arg Glu Met Asp Asp Val Ala Ile Glu Asp 545 550 555 560 Glu Val Leu Glu Gln Leu Phe Lys Asp Thr Lys Pro Glu Leu Glu Ile 565 570 575 Asp Val Lys Val Gln Lys Gln Glu Glu Asp Val Asn Val Arg Lys Arg 580 585 590 Pro Arg Met Asp Ile Glu Thr Asn Asp Thr Phe Ser Asp Glu Ala Val 595 600 605 Pro Glu Ser Ser Lys Ile Ser Gln Glu Asn Glu Ile Gly Lys Lys Arg 610 615 620 Glu Leu Lys Glu Asp Ser Leu Trp Ser Ala Lys Glu Ile Ser Asn Asn 625 630 635 640 Asp Lys Leu Gln Asp Asp Ser Glu Met Leu Pro Lys Lys Leu Leu Leu 645 650 655 Thr Glu Phe Arg Ser Leu Val Ile Lys Asn Ser Thr Ser Arg Asn Pro 660 665 670 Ser Gly Ile Asn Asp Asp Tyr Gly Gln Leu Lys Asn Phe Lys Lys Phe 675 680 685 Lys Lys Val Thr Tyr Pro Gly Ala Gly Lys Leu Pro His Ile Ile Gly 690 695 700 Gly Ser Asp Leu Ile Ala His His Ala Arg Lys Asn Thr Glu Leu Glu 705 710 715 720 Glu Trp Leu Arg Gln Glu Met Glu Val Gln Asn Gln His Ala Lys Glu 725 730 735 Glu Ser Leu Ala Asp Asp Leu Phe Arg Tyr Asn Pro Tyr Leu Lys Arg 740 745 750 Arg Arg <210> 678 <211> 280 <212> PRT <213> Homo sapiens <400> 678 Met Lys Phe Arg Ala Lys Ile Val Asp Gly Ala Cys Leu Asn His Phe 1 5 10 15 Thr Arg Ile Ser Asn Met Ile Ala Lys Leu Ala Lys Thr Cys Thr Leu 20 25 30 Arg Ile Ser Pro Asp Lys Leu Asn Phe Ile Leu Cys Asp Lys Leu Ala 35 40 45 Asn Gly Gly Val Ser Met Trp Cys Glu Leu Glu Gln Glu Asn Phe Phe 50 55 60 Asn Glu Phe Gln Met Glu Gly Val Ser Ala Glu Asn Asn Glu Ile Tyr 65 70 75 80 Leu Glu Leu Thr Ser Glu Asn Leu Ser Arg Ala Leu Lys Thr Ala Gln 85 90 95 Asn Ala Arg Ala Leu Lys Ile Lys Leu Thr Asn Lys His Phe Pro Cys 100 105 110 Leu Thr Val Ser Val Glu Leu Leu Ser Met Ser Ser Ser Ser Arg Ile 115 120 125 Val Thr His Asp Ile Pro Ile Lys Val Ile Pro Arg Lys Leu Trp Lys 130 135 140 Asp Leu Gln Glu Pro Val Val Pro Asp Pro Asp Val Ser Ile Tyr Leu 145 150 155 160 Pro Val Leu Lys Thr Met Lys Ser Val Val Glu Lys Met Lys Asn Ile 165 170 175 Ser Asn His Leu Val Ile Glu Ala Asn Leu Asp Gly Glu Leu Asn Leu 180 185 190 Lys Ile Glu Thr Glu Leu Val Cys Val Thr Thr His Phe Lys Asp Leu 195 200 205 Gly Asn Pro Pro Leu Ala Ser Glu Ser Thr His Glu Asp Arg Asn Val 210 215 220 Glu His Met Ala Glu Val His Ile Asp Ile Arg Lys Leu Leu Gln Phe 225 230 235 240 Leu Ala Gly Gln Gln Val Asn Pro Thr Lys Ala Leu Cys Asn Ile Val 245 250 255 Asn Asn Lys Met Val His Phe Asp Leu Leu His Glu Asp Val Ser Leu 260 265 270 Gln Tyr Phe Ile Pro Ala Leu Ser 275 280 <210> 679 <211> 282 <212> PRT <213> Homo sapiens <400> 679 Met Pro Leu Leu Thr Gln Gln Ile Gln Asp Glu Asp Asp Gln Tyr Ser 1 5 10 15 Leu Val Ala Ser Leu Asp Asn Val Arg Asn Leu Ser Thr Ile Leu Lys 20 25 30 Ala Ile His Phe Arg Glu His Ala Thr Cys Phe Ala Thr Lys Asn Gly 35 40 45 Ile Lys Val Thr Val Glu Asn Ala Lys Cys Val Gln Ala Asn Ala Phe 50 55 60 Ile Gln Ala Gly Ile Phe Gln Glu Phe Lys Val Gln Glu Glu Ser Val 65 70 75 80 Thr Phe Arg Ile Asn Leu Thr Val Leu Leu Asp Cys Leu Ser Ile Phe 85 90 95 Gly Ser Ser Pro Met Pro Gly Thr Leu Thr Ala Leu Arg Met Cys Tyr 100 105 110 Gln Gly Tyr Gly Tyr Pro Leu Met Leu Phe Leu Glu Glu Gly Gly Val 115 120 125 Val Thr Val Cys Lys Ile Asn Thr Gln Glu Pro Glu Glu Thr Leu Asp 130 135 140 Phe Asp Phe Cys Ser Thr Asn Val Ile Asn Lys Ile Ile Leu Gln Ser 145 150 155 160 Glu Gly Leu Arg Glu Ala Phe Ser Glu Leu Asp Met Thr Ser Glu Val 165 170 175 Leu Gln Ile Thr Met Ser Pro Asp Lys Pro Tyr Phe Arg Leu Ser Thr 180 185 190 Phe Gly Asn Ala Gly Ser Ser His Leu Asp Tyr Pro Lys Asp Ser Asp 195 200 205 Leu Met Glu Ala Phe His Cys Asn Gln Thr Gln Val Asn Arg Tyr Lys 210 215 220 Ile Ser Leu Leu Lys Pro Ser Thr Lys Ala Leu Val Leu Ser Cys Lys 225 230 235 240 Val Ser Ile Arg Thr Asp Asn Arg Gly Phe Leu Ser Leu Gln Tyr Met 245 250 255 Ile Arg Asn Glu Asp Gly Gln Ile Cys Phe Val Glu Tyr Tyr Cys Cys 260 265 270 Pro Asp Glu Glu Val Pro Glu Ser Glu Ser 275 280 <210> 680 <211> 862 <212> PRT <213> Homo sapiens <400> 680 Met Lys Thr Val Leu Met Val Ala Glu Lys Pro Ser Leu Ala Gln Ser 1 5 10 15 Ile Ala Lys Ile Leu Ser Arg Gly Ser Leu Ser Ser His Lys Gly Leu 20 25 30 Asn Gly Ala Cys Ser Val His Glu Tyr Thr Gly Thr Phe Ala Gly Gln 35 40 45 Pro Val Arg Phe Lys Met Thr Ser Val Cys Gly His Val Met Thr Leu 50 55 60 Asp Phe Leu Gly Lys Tyr Asn Lys Trp Asp Lys Val Asp Pro Ala Glu 65 70 75 80 Leu Phe Ser Gln Ala Pro Thr Glu Lys Lys Glu Ala Asn Pro Lys Leu 85 90 95 Asn Met Val Lys Phe Leu Gln Val Glu Gly Arg Gly Cys Asp Tyr Ile 100 105 110 Val Leu Trp Leu Asp Cys Asp Lys Glu Gly Glu Asn Ile Cys Phe Glu 115 120 125 Val Leu Asp Ala Val Leu Pro Val Met Asn Lys Ala His Gly Gly Glu 130 135 140 Lys Thr Val Phe Arg Ala Arg Phe Ser Ser Ile Thr Asp Thr Asp Ile 145 150 155 160 Cys Asn Ala Met Ala Cys Leu Gly Glu Pro Asp His Asn Glu Ala Leu 165 170 175 Ser Val Asp Ala Arg Gln Glu Leu Asp Leu Arg Ile Gly Cys Ala Phe 180 185 190 Thr Arg Phe Gln Thr Lys Tyr Phe Gln Gly Lys Tyr Gly Asp Leu Asp 195 200 205 Ser Ser Leu Ile Ser Phe Gly Pro Cys Gln Thr Pro Thr Leu Gly Phe 210 215 220 Cys Val Glu Arg His Asp Lys Ile Gln Ser Phe Lys Pro Glu Thr Tyr 225 230 235 240 Trp Val Leu Gln Ala Lys Val Asn Thr Asp Lys Asp Arg Ser Leu Leu 245 250 255 Leu Asp Trp Asp Arg Val Arg Val Phe Asp Arg Glu Ile Ala Gln Met 260 265 270 Phe Leu Asn Met Thr Lys Leu Glu Lys Glu Ala Gln Val Glu Ala Thr 275 280 285 Ser Arg Lys Glu Lys Ala Lys Gln Arg Pro Leu Ala Leu Asn Thr Val 290 295 300 Glu Met Leu Arg Val Ala Ser Ser Ser Leu Gly Met Gly Pro Gln His 305 310 315 320 Ala Met Gln Thr Ala Glu Arg Leu Tyr Thr Gln Gly Tyr Ile Ser Tyr 325 330 335 Pro Arg Thr Glu Thr Thr His Tyr Pro Glu Asn Phe Asp Leu Lys Gly 340 345 350 Ser Leu Arg Gln Gln Ala Asn His Pro Tyr Trp Ala Asp Thr Val Lys 355 360 365 Arg Leu Leu Ala Glu Gly Ile Asn Arg Pro Arg Lys Gly His Asp Ala 370 375 380 Gly Asp His Pro Pro Ile Thr Pro Met Lys Ser Ala Thr Glu Ala Glu 385 390 395 400 Leu Gly Gly Asp Ala Trp Arg Leu Tyr Glu Tyr Ile Thr Arg His Phe 405 410 415 Ile Ala Thr Val Ser His Asp Cys Lys Tyr Leu Gln Ser Thr Ile Ser 420 425 430 Phe Arg Ile Gly Pro Glu Leu Phe Thr Cys Ser Gly Lys Thr Val Leu 435 440 445 Ser Pro Gly Phe Thr Glu Val Met Pro Trp Gln Ser Val Pro Leu Glu 450 455 460 Glu Ser Leu Pro Thr Cys Gln Arg Gly Asp Ala Phe Pro Val Gly Glu 465 470 475 480 Val Lys Met Leu Glu Lys Gln Thr Asn Pro Pro Asp Tyr Leu Thr Glu 485 490 495 Ala Glu Leu Ile Thr Leu Met Glu Lys His Gly Ile Gly Thr Asp Ala 500 505 510 Ser Ile Pro Val His Ile Asn Asn Ile Cys Gln Arg Asn Tyr Val Thr 515 520 525 Val Glu Ser Gly Arg Arg Leu Lys Pro Thr Asn Leu Gly Ile Val Leu 530 535 540 Val His Gly Tyr Tyr Lys Ile Asp Ala Glu Leu Val Leu Pro Thr Ile 545 550 555 560 Arg Ser Ala Val Glu Lys Gln Leu Asn Leu Ile Ala Gln Gly Lys Ala 565 570 575 Asp Tyr Arg Gln Val Leu Gly His Thr Leu Asp Val Phe Lys Arg Lys 580 585 590 Phe His Tyr Phe Val Asp Ser Ile Ala Gly Met Asp Glu Leu Met Glu 595 600 605 Val Ser Phe Ser Pro Leu Ala Ala Thr Gly Lys Pro Leu Ser Arg Cys 610 615 620 Gly Lys Cys His Arg Phe Met Lys Tyr Ile Gln Ala Lys Pro Ser Arg 625 630 635 640 Leu His Cys Ser His Cys Asp Glu Thr Tyr Thr Leu Pro Gln Asn Gly 645 650 655 Thr Ile Lys Leu Tyr Lys Glu Leu Arg Cys Pro Leu Asp Asp Phe Glu 660 665 670 Leu Val Leu Trp Ser Ser Gly Ser Arg Gly Lys Ser Tyr Pro Leu Cys 675 680 685 Pro Tyr Cys Tyr Asn His Pro Pro Phe Arg Asp Met Lys Lys Gly Met 690 695 700 Gly Cys Asn Glu Cys Thr His Pro Ser Cys Gln His Ser Leu Ser Met 705 710 715 720 Leu Gly Ile Gly Gln Cys Val Glu Cys Glu Ser Gly Val Leu Val Leu 725 730 735 Asp Pro Thr Ser Gly Pro Lys Trp Lys Val Ala Cys Asn Lys Cys Asn 740 745 750 Val Val Ala His Cys Phe Glu Asn Ala His Arg Val Arg Val Ser Ala 755 760 765 Asp Thr Cys Ser Val Cys Glu Ala Ala Leu Leu Asp Val Asp Phe Asn 770 775 780 Lys Ala Lys Ser Pro Leu Pro Gly Asp Glu Thr Gln His Met Gly Cys 785 790 795 800 Val Phe Cys Asp Pro Val Phe Gln Glu Leu Val Glu Leu Lys His Ala 805 810 815 Ala Ser Cys His Pro Met His Arg Gly Gly Pro Gly Arg Arg Gln Gly 820 825 830 Arg Gly Arg Gly Arg Ala Arg Arg Pro Pro Gly Lys Pro Asn Pro Arg 835 840 845 Arg Pro Lys Asp Lys Met Ser Ala Leu Ala Ala Tyr Phe Val 850 855 860 <210> 681 <211> 152 <212> PRT <213> Homo sapiens <400> 681 Met Ser Thr Pro Ala Arg Arg Arg Leu Met Arg Asp Phe Lys Arg Leu 1 5 10 15 Gln Glu Asp Pro Pro Ala Gly Val Ser Gly Ala Pro Ser Glu Asn Asn 20 25 30 Ile Met Val Trp Asn Ala Val Ile Phe Gly Pro Glu Gly Thr Pro Phe 35 40 45 Glu Asp Gly Thr Phe Lys Leu Thr Ile Glu Phe Thr Glu Glu Tyr Pro 50 55 60 Asn Lys Pro Pro Thr Val Arg Phe Val Ser Lys Met Phe His Pro Asn 65 70 75 80 Val Tyr Ala Asp Gly Ser Ile Cys Leu Asp Ile Leu Gln Asn Arg Trp 85 90 95 Ser Pro Thr Tyr Asp Val Ser Ser Ile Leu Thr Ser Ile Gln Ser Leu 100 105 110 Leu Asp Glu Pro Asn Pro Asn Ser Pro Ala Asn Ser Gln Ala Ala Gln 115 120 125 Leu Tyr Gln Glu Asn Lys Arg Glu Tyr Glu Lys Arg Val Ser Ala Ile 130 135 140 Val Glu Gln Ser Trp Arg Asp Cys 145 150 <210> 682 <211> 495 <212> PRT <213> Homo sapiens <400> 682 Met Asp Ser Leu Ala Glu Ser Arg Trp Pro Pro Gly Leu Ala Val Met 1 5 10 15 Lys Thr Ile Asp Asp Leu Leu Arg Cys Gly Ile Cys Phe Glu Tyr Phe 20 25 30 Asn Ile Ala Met Ile Ile Pro Gln Cys Ser His Asn Tyr Cys Ser Leu 35 40 45 Cys Ile Arg Lys Phe Leu Ser Tyr Lys Thr Gln Cys Pro Thr Cys Cys 50 55 60 Val Thr Val Thr Glu Pro Asp Leu Lys Asn Asn Arg Ile Leu Asp Glu 65 70 75 80 Leu Val Lys Ser Leu Asn Phe Ala Arg Asn His Leu Leu Gln Phe Ala 85 90 95 Leu Glu Ser Pro Ala Lys Ser Pro Ala Ser Ser Ser Ser Lys Asn Leu 100 105 110 Ala Val Lys Val Tyr Thr Pro Val Ala Ser Arg Gln Ser Leu Lys Gln 115 120 125 Gly Ser Arg Leu Met Asp Asn Phe Leu Ile Arg Glu Met Ser Gly Ser 130 135 140 Thr Ser Glu Leu Leu Ile Lys Glu Asn Lys Ser Lys Phe Ser Pro Gln 145 150 155 160 Lys Glu Ala Ser Pro Ala Ala Lys Thr Lys Glu Thr Arg Ser Val Glu 165 170 175 Glu Ile Ala Pro Asp Pro Ser Glu Ala Lys Arg Pro Glu Pro Pro Ser 180 185 190 Thr Ser Thr Leu Lys Gln Val Thr Lys Val Asp Cys Pro Val Cys Gly 195 200 205 Val Asn Ile Pro Glu Ser His Ile Asn Lys His Leu Asp Ser Cys Leu 210 215 220 Ser Arg Glu Glu Lys Lys Glu Ser Leu Arg Ser Ser Val His Lys Arg 225 230 235 240 Lys Pro Leu Pro Lys Thr Val Tyr Asn Leu Leu Ser Asp Arg Asp Leu 245 250 255 Lys Lys Lys Leu Lys Glu His Gly Leu Ser Ile Gln Gly Asn Lys Gln 260 265 270 Gln Leu Ile Lys Arg His Gln Glu Phe Val His Met Tyr Asn Ala Gln 275 280 285 Cys Asp Ala Leu His Pro Lys Ser Ala Ala Glu Ile Val Gln Glu Ile 290 295 300 Glu Asn Ile Glu Lys Thr Arg Met Arg Leu Glu Ala Ser Lys Leu Asn 305 310 315 320 Glu Ser Val Met Val Phe Thr Lys Asp Gln Thr Glu Lys Glu Ile Asp 325 330 335 Glu Ile His Ser Lys Tyr Arg Lys Lys His Lys Ser Glu Phe Gln Leu 340 345 350 Leu Val Asp Gln Ala Arg Lys Gly Tyr Lys Lys Ile Ala Gly Met Ser 355 360 365 Gln Lys Thr Val Thr Ile Thr Lys Glu Asp Glu Ser Thr Glu Lys Leu 370 375 380 Ser Ser Val Cys Met Gly Gln Glu Asp Asn Met Thr Ser Val Thr Asn 385 390 395 400 His Phe Ser Gln Ser Lys Leu Asp Ser Pro Glu Glu Leu Glu Pro Asp 405 410 415 Arg Glu Glu Asp Ser Ser Ser Cys Ile Asp Ile Gln Glu Val Leu Ser 420 425 430 Ser Ser Glu Ser Asp Ser Cys Asn Ser Ser Ser Ser Asp Ile Ile Arg 435 440 445 Asp Leu Leu Glu Glu Glu Glu Ala Trp Glu Ala Ser His Lys Asn Asp 450 455 460 Leu Gln Asp Thr Glu Ile Ser Pro Arg Gln Asn Arg Arg Thr Arg Ala 465 470 475 480 Ala Glu Ser Ala Glu Ile Glu Pro Arg Asn Lys Arg Asn Arg Asn 485 490 495 <210> 683 <211> 152 <212> PRT <213> Homo sapiens <400> 683 Met Ala Gly Leu Pro Arg Arg Ile Ile Lys Glu Thr Gln Arg Leu Leu 1 5 10 15 Ala Glu Pro Val Pro Gly Ile Lys Ala Glu Pro Asp Glu Ser Asn Ala 20 25 30 Arg Tyr Phe His Val Val Ile Ala Gly Pro Gln Asp Ser Pro Phe Glu 35 40 45 Gly Gly Thr Phe Lys Leu Glu Leu Phe Leu Pro Glu Glu Tyr Pro Met 50 55 60 Ala Ala Pro Lys Val Arg Phe Met Thr Lys Ile Tyr His Pro Asn Val 65 70 75 80 Asp Lys Leu Gly Arg Ile Cys Leu Asp Ile Leu Lys Asp Lys Trp Ser 85 90 95 Pro Ala Leu Gln Ile Arg Thr Val Leu Leu Ser Ile Gln Ala Leu Leu 100 105 110 Ser Ala Pro Asn Pro Asp Asp Pro Leu Ala Asn Asp Val Ala Glu Gln 115 120 125 Trp Lys Thr Asn Glu Ala Gln Ala Ile Glu Thr Ala Arg Ala Trp Thr 130 135 140 Arg Leu Tyr Ala Met Asn Asn Ile 145 150 <210> 684 <211> 969 <212> PRT <213> Homo sapiens <400> 684 Met Ala Lys Ser Asn Ser Val Gly Gln Asp Ser Cys Gln Asp Ser Glu 1 5 10 15 Gly Asp Met Ile Phe Pro Ala Glu Ser Ser Cys Ala Leu Pro Gln Glu 20 25 30 Gly Ser Ala Gly Pro Gly Ser Pro Gly Ser Ala Pro Pro Ser Arg Lys 35 40 45 Arg Ser Trp Ser Ser Glu Glu Glu Ser Asn Gln Ala Thr Gly Thr Ser 50 55 60 Arg Trp Asp Gly Val Ser Lys Lys Ala Pro Arg His His Leu Ser Val 65 70 75 80 Pro Cys Thr Arg Pro Arg Glu Ala Arg Gln Glu Ala Glu Asp Ser Thr 85 90 95 Ser Arg Leu Ser Ala Glu Ser Gly Glu Thr Asp Gln Asp Ala Gly Asp 100 105 110 Val Gly Pro Asp Pro Ile Pro Asp Ser Tyr Tyr Gly Leu Leu Gly Thr 115 120 125 Leu Pro Cys Gln Glu Ala Leu Ser His Ile Cys Ser Leu Pro Ser Glu 130 135 140 Val Leu Arg His Val Phe Ala Phe Leu Pro Val Glu Asp Leu Tyr Trp 145 150 155 160 Asn Leu Ser Leu Val Cys His Leu Trp Arg Glu Ile Ile Ser Asp Pro 165 170 175 Leu Phe Ile Pro Trp Lys Lys Leu Tyr His Arg Tyr Leu Met Asn Glu 180 185 190 Glu Gln Ala Val Ser Lys Val Asp Gly Ile Leu Ser Asn Cys Gly Ile 195 200 205 Glu Lys Glu Ser Asp Leu Cys Val Leu Asn Leu Ile Arg Tyr Thr Ala 210 215 220 Thr Thr Lys Cys Ser Pro Ser Val Asp Pro Glu Arg Val Leu Trp Ser 225 230 235 240 Leu Arg Asp His Pro Leu Leu Pro Glu Ala Glu Ala Cys Val Arg Gln 245 250 255 His Leu Pro Asp Leu Tyr Ala Ala Ala Gly Gly Val Asn Ile Trp Ala 260 265 270 Leu Val Ala Ala Val Val Leu Leu Ser Ser Ser Val Asn Asp Ile Gln 275 280 285 Arg Leu Leu Phe Cys Leu Arg Arg Pro Ser Ser Thr Val Thr Met Pro 290 295 300 Asp Val Thr Glu Thr Leu Tyr Cys Ile Ala Val Leu Leu Tyr Ala Met 305 310 315 320 Arg Glu Lys Gly Ile Asn Ile Ser Asn Arg Ile His Tyr Asn Ile Phe 325 330 335 Tyr Cys Leu Tyr Leu Gln Glu Asn Ser Cys Thr Gln Ala Thr Lys Val 340 345 350 Lys Glu Glu Pro Ser Val Trp Pro Gly Lys Lys Thr Ile Gln Leu Thr 355 360 365 His Glu Gln Gln Leu Ile Leu Asn His Lys Met Glu Pro Leu Gln Val 370 375 380 Val Lys Ile Met Ala Phe Ala Gly Thr Gly Lys Thr Ser Thr Leu Val 385 390 395 400 Lys Tyr Ala Glu Lys Trp Ser Gln Ser Arg Phe Leu Tyr Val Thr Phe 405 410 415 Asn Lys Ser Ile Ala Lys Gln Ala Glu Arg Val Phe Pro Ser Asn Val 420 425 430 Ile Cys Lys Thr Phe His Ser Met Ala Tyr Gly His Ile Gly Arg Lys 435 440 445 Tyr Gln Ser Lys Lys Lys Leu Asn Leu Phe Lys Leu Thr Pro Phe Met 450 455 460 Val Asn Ser Val Leu Ala Glu Gly Lys Gly Gly Phe Ile Arg Ala Lys 465 470 475 480 Leu Val Cys Lys Thr Leu Glu Asn Phe Phe Ala Ser Ala Asp Glu Glu 485 490 495 Leu Thr Ile Asp His Val Pro Ile Trp Cys Lys Asn Ser Gln Gly Gln 500 505 510 Arg Val Met Val Glu Gln Ser Glu Lys Leu Asn Gly Val Leu Glu Ala 515 520 525 Ser Arg Leu Trp Asp Asn Met Arg Lys Leu Gly Glu Cys Thr Glu Glu 530 535 540 Ala His Gln Met Thr His Asp Gly Tyr Leu Lys Leu Trp Gln Leu Ser 545 550 555 560 Lys Pro Ser Leu Ala Ser Phe Asp Ala Ile Phe Val Asp Glu Ala Gln 565 570 575 Asp Cys Thr Pro Ala Ile Met Asn Ile Val Leu Ser Gln Pro Cys Gly 580 585 590 Lys Ile Phe Val Gly Asp Pro His Gln Gln Ile Tyr Thr Phe Arg Gly 595 600 605 Ala Val Asn Ala Leu Phe Thr Val Pro His Thr His Val Phe Tyr Leu 610 615 620 Thr Gln Ser Phe Arg Phe Gly Val Glu Ile Ala Tyr Val Gly Ala Thr 625 630 635 640 Ile Leu Asp Val Cys Lys Arg Val Arg Lys Lys Thr Leu Val Gly Gly 645 650 655 Asn His Gln Ser Gly Ile Arg Gly Asp Ala Lys Gly Gln Val Ala Leu 660 665 670 Leu Ser Arg Thr Asn Ala Asn Val Phe Asp Glu Ala Val Arg Val Thr 675 680 685 Glu Gly Glu Phe Pro Ser Arg Ile His Leu Ile Gly Gly Ile Lys Ser 690 695 700 Phe Gly Leu Asp Arg Ile Ile Asp Ile Trp Ile Leu Leu Gln Pro Glu 705 710 715 720 Glu Glu Arg Arg Lys Gln Asn Leu Val Ile Lys Asp Lys Phe Ile Arg 725 730 735 Arg Trp Val His Lys Glu Gly Phe Ser Gly Phe Lys Arg Tyr Val Thr 740 745 750 Ala Ala Glu Asp Lys Glu Leu Glu Ala Lys Ile Ala Val Val Glu Lys 755 760 765 Tyr Asn Ile Arg Ile Pro Glu Leu Val Gln Arg Ile Glu Lys Cys His 770 775 780 Ile Glu Asp Leu Asp Phe Ala Glu Tyr Ile Leu Gly Thr Val His Lys 785 790 795 800 Ala Lys Gly Leu Glu Phe Asp Thr Val His Val Leu Asp Asp Phe Val 805 810 815 Lys Val Pro Cys Ala Arg His Asn Leu Pro Gln Leu Pro His Phe Arg 820 825 830 Val Glu Ser Phe Ser Glu Asp Glu Trp Asn Leu Leu Tyr Val Ala Val 835 840 845 Thr Arg Ala Lys Lys Arg Leu Ile Met Thr Lys Ser Leu Glu Asn Ile 850 855 860 Leu Thr Leu Ala Gly Glu Tyr Phe Leu Gln Ala Glu Leu Thr Ser Asn 865 870 875 880 Val Leu Lys Thr Gly Val Val Arg Cys Cys Val Gly Gln Cys Asn Asn 885 890 895 Ala Ile Pro Val Asp Thr Val Leu Thr Met Lys Lys Leu Pro Ile Thr 900 905 910 Tyr Ser Asn Arg Lys Glu Asn Lys Gly Gly Tyr Leu Cys His Ser Cys 915 920 925 Ala Glu Gln Arg Ile Gly Pro Leu Ala Phe Leu Thr Ala Ser Pro Glu 930 935 940 Gln Val Arg Ala Met Glu Arg Thr Val Glu Asn Ile Val Leu Pro Arg 945 950 955 960 His Glu Ala Leu Leu Phe Leu Val Phe 965 <210> 685 <211> 205 <212> PRT <213> Homo sapiens <400> 685 Met Ala Leu Gln Leu Ser Arg Glu Gln Gly Ile Thr Leu Arg Gly Ser 1 5 10 15 Ala Glu Ile Val Ala Glu Phe Phe Ser Phe Gly Ile Asn Ser Ile Leu 20 25 30 Tyr Gln Arg Gly Ile Tyr Pro Ser Glu Thr Phe Thr Arg Val Gln Lys 35 40 45 Tyr Gly Leu Thr Leu Leu Val Thr Thr Asp Leu Glu Leu Ile Lys Tyr 50 55 60 Leu Asn Asn Val Val Glu Gln Leu Lys Asp Trp Leu Tyr Lys Cys Ser 65 70 75 80 Val Gln Lys Leu Val Val Val Ile Ser Asn Ile Glu Ser Gly Glu Val 85 90 95 Leu Glu Arg Trp Gln Phe Asp Ile Glu Cys Asp Lys Thr Ala Lys Asp 100 105 110 Asp Ser Ala Pro Arg Glu Lys Ser Gln Lys Ala Ile Gln Asp Glu Ile 115 120 125 Arg Ser Val Ile Arg Gln Ile Thr Ala Thr Val Thr Phe Leu Pro Leu 130 135 140 Leu Glu Val Ser Cys Ser Phe Asp Leu Leu Ile Tyr Thr Asp Lys Asp 145 150 155 160 Leu Val Val Pro Glu Lys Trp Glu Glu Ser Gly Pro Gln Phe Ile Thr 165 170 175 Asn Ser Glu Glu Val Arg Leu Arg Ser Phe Thr Thr Thr Ile His Lys 180 185 190 Val Asn Ser Met Val Ala Tyr Lys Ile Pro Val Asn Asp 195 200 205 <210> 686 <211> 940 <212> PRT <213> Homo sapiens <400> 686 Met Ala Arg Lys Arg Ala Ala Gly Gly Glu Pro Arg Gly Arg Glu Leu 1 5 10 15 Arg Ser Gln Lys Ser Lys Ala Lys Ser Lys Ala Arg Arg Glu Glu Glu 20 25 30 Glu Glu Asp Ala Phe Glu Asp Glu Lys Pro Pro Lys Lys Ser Leu Leu 35 40 45 Ser Lys Val Ser Gln Gly Lys Arg Lys Arg Gly Cys Ser His Pro Gly 50 55 60 Gly Ser Ala Asp Gly Pro Ala Lys Lys Lys Val Ala Lys Val Thr Val 65 70 75 80 Lys Ser Glu Asn Leu Lys Val Ile Lys Asp Glu Ala Leu Ser Asp Gly 85 90 95 Asp Asp Leu Arg Asp Phe Pro Ser Asp Leu Lys Lys Ala His His Leu 100 105 110 Lys Arg Gly Ala Thr Met Asn Glu Asp Ser Asn Glu Glu Glu Glu Glu 115 120 125 Ser Glu Asn Asp Trp Glu Glu Val Glu Glu Leu Ser Glu Pro Val Leu 130 135 140 Gly Asp Val Arg Glu Ser Thr Ala Phe Ser Arg Ser Leu Leu Pro Val 145 150 155 160 Lys Pro Val Glu Ile Glu Ile Glu Thr Pro Glu Gln Ala Lys Thr Arg 165 170 175 Glu Arg Ser Glu Lys Ile Lys Leu Glu Phe Glu Thr Tyr Leu Arg Arg 180 185 190 Ala Met Lys Arg Phe Asn Lys Gly Val His Glu Asp Thr His Lys Val 195 200 205 His Leu Leu Cys Leu Leu Ala Asn Gly Phe Tyr Arg Asn Asn Ile Cys 210 215 220 Ser Gln Pro Asp Leu His Ala Ile Gly Leu Ser Ile Ile Pro Ala Arg 225 230 235 240 Phe Thr Arg Val Leu Pro Arg Asp Val Asp Thr Tyr Tyr Leu Ser Asn 245 250 255 Leu Val Lys Trp Phe Ile Gly Thr Phe Thr Val Asn Ala Glu Leu Ser 260 265 270 Ala Ser Glu Gln Asp Asn Leu Gln Thr Thr Leu Glu Arg Arg Phe Ala 275 280 285 Ile Tyr Ser Ala Arg Asp Asp Glu Glu Leu Val His Ile Phe Leu Leu 290 295 300 Ile Leu Arg Ala Leu Gln Leu Leu Thr Arg Leu Val Leu Ser Leu Gln 305 310 315 320 Pro Ile Pro Leu Lys Ser Ala Thr Ala Lys Gly Lys Lys Pro Ser Lys 325 330 335 Glu Arg Leu Thr Ala Asp Pro Gly Gly Ser Ser Glu Thr Ser Ser Gln 340 345 350 Val Leu Glu Asn His Thr Lys Pro Lys Thr Ser Lys Gly Thr Lys Gln 355 360 365 Glu Glu Thr Phe Ala Lys Gly Thr Cys Arg Pro Ser Ala Lys Gly Lys 370 375 380 Arg Asn Lys Gly Gly Arg Lys Lys Arg Ser Lys Pro Ser Ser Ser Glu 385 390 395 400 Glu Asp Glu Gly Pro Gly Asp Lys Gln Glu Lys Ala Thr Gln Arg Arg 405 410 415 Pro His Gly Arg Glu Arg Arg Val Ala Ser Arg Val Ser Tyr Lys Glu 420 425 430 Glu Ser Gly Ser Asp Glu Ala Gly Ser Gly Ser Asp Phe Glu Leu Ser 435 440 445 Ser Gly Glu Ala Ser Asp Pro Ser Asp Glu Asp Ser Glu Pro Gly Pro 450 455 460 Pro Lys Gln Arg Lys Ala Pro Ala Pro Gln Arg Thr Lys Ala Gly Ser 465 470 475 480 Lys Ser Ala Ser Arg Thr His Arg Gly Ser His Arg Lys Asp Pro Ser 485 490 495 Leu Pro Ala Ala Ser Ser Ser Ser Ser Ser Ser Lys Arg Gly Lys Lys 500 505 510 Met Cys Ser Asp Gly Glu Lys Ala Glu Lys Arg Ser Ile Ala Gly Ile 515 520 525 Asp Gln Trp Leu Glu Val Phe Cys Glu Gln Glu Glu Lys Trp Val Cys 530 535 540 Val Asp Cys Val His Gly Val Val Gly Gln Pro Leu Thr Cys Tyr Lys 545 550 555 560 Tyr Ala Thr Lys Pro Met Thr Tyr Val Val Gly Ile Asp Ser Asp Gly 565 570 575 Trp Val Arg Asp Val Thr Gln Arg Tyr Asp Pro Val Trp Met Thr Val 580 585 590 Thr Arg Lys Cys Arg Val Asp Ala Glu Trp Trp Ala Glu Thr Leu Arg 595 600 605 Pro Tyr Gln Ser Pro Phe Met Asp Arg Glu Lys Lys Glu Asp Leu Glu 610 615 620 Phe Gln Ala Lys His Met Asp Gln Pro Leu Pro Thr Ala Ile Gly Leu 625 630 635 640 Tyr Lys Asn His Pro Leu Tyr Ala Leu Lys Arg His Leu Leu Lys Tyr 645 650 655 Glu Ala Ile Tyr Pro Glu Thr Ala Ala Ile Leu Gly Tyr Cys Arg Gly 660 665 670 Glu Ala Val Tyr Ser Arg Asp Cys Val His Thr Leu His Ser Arg Asp 675 680 685 Thr Trp Leu Lys Lys Ala Arg Val Val Arg Leu Gly Glu Val Pro Tyr 690 695 700 Lys Met Val Lys Gly Phe Ser Asn Arg Ala Arg Lys Ala Arg Leu Ala 705 710 715 720 Glu Pro Gln Leu Arg Glu Glu Asn Asp Leu Gly Leu Phe Gly Tyr Trp 725 730 735 Gln Thr Glu Glu Tyr Gln Pro Pro Val Ala Val Asp Gly Lys Val Pro 740 745 750 Arg Asn Glu Phe Gly Asn Val Tyr Leu Phe Leu Pro Ser Met Met Pro 755 760 765 Ile Gly Cys Val Gln Leu Asn Leu Pro Asn Leu His Arg Val Ala Arg 770 775 780 Lys Leu Asp Ile Asp Cys Val Gln Ala Ile Thr Gly Phe Asp Phe His 785 790 795 800 Gly Gly Tyr Ser His Pro Val Thr Asp Gly Tyr Ile Val Cys Glu Glu 805 810 815 Phe Lys Asp Val Leu Leu Thr Ala Trp Glu Asn Glu Gln Ala Val Ile 820 825 830 Glu Arg Lys Glu Lys Glu Lys Lys Glu Lys Arg Ala Leu Gly Asn Trp 835 840 845 Lys Leu Leu Ala Lys Gly Leu Leu Ile Arg Glu Arg Leu Lys Arg Arg 850 855 860 Tyr Gly Pro Lys Ser Glu Ala Ala Ala Pro His Thr Asp Ala Gly Gly 865 870 875 880 Gly Leu Ser Ser Asp Glu Glu Glu Gly Thr Ser Ser Gln Ala Glu Ala 885 890 895 Ala Arg Ile Leu Ala Ala Ser Trp Pro Gln Asn Arg Glu Asp Glu Glu 900 905 910 Lys Gln Lys Leu Lys Gly Gly Pro Lys Lys Thr Lys Arg Glu Lys Lys 915 920 925 Ala Ala Ala Ser His Leu Phe Pro Phe Glu Lys Leu 930 935 940 <210> 687 <211> 363 <212> PRT <213> Homo sapiens <400> 687 Met Ala Val Thr Ile Thr Leu Lys Thr Leu Gln Gln Gln Thr Phe Lys 1 5 10 15 Ile Arg Met Glu Pro Asp Glu Thr Val Lys Val Leu Lys Glu Lys Ile 20 25 30 Glu Ala Glu Lys Gly Arg Asp Ala Phe Pro Val Ala Gly Gln Lys Leu 35 40 45 Ile Tyr Ala Gly Lys Ile Leu Ser Asp Asp Val Pro Ile Arg Asp Tyr 50 55 60 Arg Ile Asp Glu Lys Asn Phe Val Val Val Met Val Thr Lys Thr Lys 65 70 75 80 Ala Gly Gln Gly Thr Ser Ala Pro Pro Glu Ala Ser Pro Thr Ala Ala 85 90 95 Pro Glu Ser Ser Thr Ser Phe Pro Pro Ala Pro Thr Ser Gly Met Ser 100 105 110 His Pro Pro Pro Ala Ala Arg Glu Asp Lys Ser Pro Ser Glu Glu Ser 115 120 125 Ala Pro Thr Thr Ser Pro Glu Ser Val Ser Gly Ser Val Pro Ser Ser 130 135 140 Gly Ser Ser Gly Arg Glu Glu Asp Ala Ala Ser Thr Leu Val Thr Gly 145 150 155 160 Ser Glu Tyr Glu Thr Met Leu Thr Glu Ile Met Ser Met Gly Tyr Glu 165 170 175 Arg Glu Arg Val Val Ala Ala Leu Arg Ala Ser Tyr Asn Asn Pro His 180 185 190 Arg Ala Val Glu Tyr Leu Leu Thr Gly Ile Pro Gly Ser Pro Glu Pro 195 200 205 Glu His Gly Ser Val Gln Glu Ser Gln Val Ser Glu Gln Pro Ala Thr 210 215 220 Glu Ala Ala Gly Glu Asn Pro Leu Glu Phe Leu Arg Asp Gln Pro Gln 225 230 235 240 Phe Gln Asn Met Arg Gln Val Ile Gln Gln Asn Pro Ala Leu Leu Pro 245 250 255 Ala Leu Leu Gln Gln Leu Gly Gln Glu Asn Pro Gln Leu Leu Gln Gln 260 265 270 Ile Ser Arg His Gln Glu Gln Phe Ile Gln Met Leu Asn Glu Pro Pro 275 280 285 Gly Glu Leu Ala Asp Ile Ser Asp Val Glu Gly Glu Val Gly Ala Ile 290 295 300 Gly Glu Glu Ala Pro Gln Met Asn Tyr Ile Gln Val Thr Pro Gln Glu 305 310 315 320 Lys Glu Ala Ile Glu Arg Leu Lys Ala Leu Gly Phe Pro Glu Ser Leu 325 330 335 Val Ile Gln Ala Tyr Phe Ala Cys Glu Lys Asn Glu Asn Leu Ala Ala 340 345 350 Asn Phe Leu Leu Ser Gln Asn Phe Asp Asp Glu 355 360 <210> 688 <211> 409 <212> PRT <213> Homo sapiens <400> 688 Met Gln Val Thr Leu Lys Thr Leu Gln Gln Gln Thr Phe Lys Ile Asp 1 5 10 15 Ile Asp Pro Glu Glu Thr Val Lys Ala Leu Lys Glu Lys Ile Glu Ser 20 25 30 Glu Lys Gly Lys Asp Ala Phe Pro Val Ala Gly Gln Lys Leu Ile Tyr 35 40 45 Ala Gly Lys Ile Leu Asn Asp Asp Thr Ala Leu Lys Glu Tyr Lys Ile 50 55 60 Asp Glu Lys Asn Phe Val Val Val Met Val Thr Lys Pro Lys Ala Val 65 70 75 80 Ser Thr Pro Ala Pro Ala Thr Thr Gln Gln Ser Ala Pro Ala Ser Thr 85 90 95 Thr Ala Val Thr Ser Ser Thr Thr Thr Thr Val Ala Gln Ala Pro Thr 100 105 110 Pro Val Pro Ala Leu Ala Pro Thr Ser Thr Pro Ala Ser Ile Thr Pro 115 120 125 Ala Ser Ala Thr Ala Ser Ser Glu Pro Ala Pro Ala Ser Ala Ala Lys 130 135 140 Gln Glu Lys Pro Ala Glu Lys Pro Ala Glu Thr Pro Val Ala Thr Ser 145 150 155 160 Pro Thr Ala Thr Asp Ser Thr Ser Gly Asp Ser Ser Arg Ser Asn Leu 165 170 175 Phe Glu Asp Ala Thr Ser Ala Leu Val Thr Gly Gln Ser Tyr Glu Asn 180 185 190 Met Val Thr Glu Ile Met Ser Met Gly Tyr Glu Arg Glu Gln Val Ile 195 200 205 Ala Ala Leu Arg Ala Ser Phe Asn Asn Pro Asp Arg Ala Val Glu Tyr 210 215 220 Leu Leu Met Gly Ile Pro Gly Asp Arg Glu Ser Gln Ala Val Val Asp 225 230 235 240 Pro Pro Gln Ala Ala Ser Thr Gly Ala Pro Gln Ser Ser Ala Val Ala 245 250 255 Ala Ala Ala Ala Thr Thr Thr Ala Thr Thr Thr Thr Thr Ser Ser Gly 260 265 270 Gly His Pro Leu Glu Phe Leu Arg Asn Gln Pro Gln Phe Gln Gln Met 275 280 285 Arg Gln Ile Ile Gln Gln Asn Pro Ser Leu Leu Pro Ala Leu Leu Gln 290 295 300 Gln Ile Gly Arg Glu Asn Pro Gln Leu Leu Gln Gln Ile Ser Gln His 305 310 315 320 Gln Glu His Phe Ile Gln Met Leu Asn Glu Pro Val Gln Glu Ala Gly 325 330 335 Gly Gln Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly Ile Ala Glu Ala 340 345 350 Gly Ser Gly His Met Asn Tyr Ile Gln Val Thr Pro Gln Glu Lys Glu 355 360 365 Ala Ile Glu Arg Leu Lys Ala Leu Gly Phe Pro Glu Gly Leu Val Ile 370 375 380 Gln Ala Tyr Phe Ala Cys Glu Lys Asn Glu Asn Leu Ala Ala Asn Phe 385 390 395 400 Leu Leu Gln Gln Asn Phe Asp Glu Asp 405 <210> 689 <211> 396 <212> PRT <213> Homo sapiens <400> 689 Met Leu Gly Phe Leu Ser Ala Arg Gln Thr Gly Leu Glu Asp Pro Leu 1 5 10 15 Arg Leu Arg Arg Ala Glu Ser Thr Arg Arg Val Leu Gly Leu Glu Leu 20 25 30 Asn Lys Asp Arg Asp Val Glu Arg Ile His Gly Gly Gly Ile Asn Thr 35 40 45 Leu Asp Ile Glu Pro Val Glu Gly Arg Tyr Met Leu Ser Gly Gly Ser 50 55 60 Asp Gly Val Ile Val Leu Tyr Asp Leu Glu Asn Ser Ser Arg Gln Ser 65 70 75 80 Tyr Tyr Thr Cys Lys Ala Val Cys Ser Ile Gly Arg Asp His Pro Asp 85 90 95 Val His Arg Tyr Ser Val Glu Thr Val Gln Trp Tyr Pro His Asp Thr 100 105 110 Gly Met Phe Thr Ser Ser Ser Phe Asp Lys Thr Leu Lys Val Trp Asp 115 120 125 Thr Asn Thr Leu Gln Thr Ala Asp Val Phe Asn Phe Glu Glu Thr Val 130 135 140 Tyr Ser His His Met Ser Pro Val Ser Thr Lys His Cys Leu Val Ala 145 150 155 160 Val Gly Thr Arg Gly Pro Lys Val Gln Leu Cys Asp Leu Lys Ser Gly 165 170 175 Ser Cys Ser His Ile Leu Gln Gly His Arg Gln Glu Ile Leu Ala Val 180 185 190 Ser Trp Ser Pro Arg Tyr Asp Tyr Ile Leu Ala Thr Ala Ser Ala Asp 195 200 205 Ser Arg Val Lys Leu Trp Asp Val Arg Arg Ala Ser Gly Cys Leu Ile 210 215 220 Thr Leu Asp Gln His Asn Gly Lys Lys Ser Gln Ala Val Glu Ser Ala 225 230 235 240 Asn Thr Ala His Asn Gly Lys Val Asn Gly Leu Cys Phe Thr Ser Asp 245 250 255 Gly Leu His Leu Leu Thr Val Gly Thr Asp Asn Arg Met Arg Leu Trp 260 265 270 Asn Ser Ser Asn Gly Glu Asn Thr Leu Val Asn Tyr Gly Lys Val Cys 275 280 285 Asn Asn Ser Lys Lys Gly Leu Lys Phe Thr Val Ser Cys Gly Cys Ser 290 295 300 Ser Glu Phe Val Phe Val Pro Tyr Gly Ser Thr Ile Ala Val Tyr Thr 305 310 315 320 Val Tyr Ser Gly Glu Gln Ile Thr Met Leu Lys Gly His Tyr Lys Thr 325 330 335 Val Asp Cys Cys Val Phe Gln Ser Asn Phe Gln Glu Leu Tyr Ser Gly 340 345 350 Ser Arg Asp Cys Asn Ile Leu Ala Trp Val Pro Ser Leu Tyr Glu Pro 355 360 365 Val Pro Asp Asp Asp Glu Thr Thr Thr Lys Ser Gln Leu Asn Pro Ala 370 375 380 Phe Glu Asp Ala Trp Ser Ser Ser Asp Glu Glu Gly 385 390 395 <210> 690 <211> 1493 <212> PRT <213> Homo sapiens <400> 690 Met Pro Asn Glu Gly Ile Pro His Ser Ser Gln Thr Gln Glu Gln Asp 1 5 10 15 Cys Leu Gln Ser Gln Pro Val Ser Asn Asn Glu Glu Met Ala Ile Lys 20 25 30 Gln Glu Ser Gly Gly Asp Gly Glu Val Glu Glu Tyr Leu Ser Phe Arg 35 40 45 Ser Val Gly Asp Gly Leu Ser Thr Ser Ala Val Gly Cys Ala Ser Ala 50 55 60 Ala Pro Arg Arg Gly Pro Ala Leu Leu His Ile Asp Arg His Gln Ile 65 70 75 80 Gln Ala Val Glu Pro Ser Ala Gln Ala Leu Glu Leu Gln Gly Leu Gly 85 90 95 Val Asp Val Tyr Asp Gln Asp Val Leu Glu Gln Gly Val Leu Gln Gln 100 105 110 Val Asp Asn Ala Ile His Glu Ala Ser Arg Ala Ser Gln Leu Val Asp 115 120 125 Val Glu Lys Glu Tyr Arg Ser Val Leu Asp Asp Leu Thr Ser Cys Thr 130 135 140 Thr Ser Leu Arg Gln Ile Asn Lys Ile Ile Glu Gln Leu Ser Pro Gln 145 150 155 160 Ala Ala Thr Ser Arg Asp Ile Asn Arg Lys Leu Asp Ser Val Lys Arg 165 170 175 Gln Lys Tyr Asn Lys Glu Gln Gln Leu Lys Lys Ile Thr Ala Lys Gln 180 185 190 Lys His Leu Gln Ala Ile Leu Gly Gly Ala Glu Val Lys Ile Glu Leu 195 200 205 Asp His Ala Ser Leu Glu Glu Asp Ala Glu Pro Gly Pro Ser Ser Leu 210 215 220 Gly Ser Met Leu Met Pro Val Gln Glu Thr Ala Trp Glu Glu Leu Ile 225 230 235 240 Arg Thr Gly Gln Met Thr Pro Phe Gly Thr Gln Ile Pro Gln Lys Gln 245 250 255 Glu Lys Lys Pro Arg Lys Ile Met Leu Asn Glu Ala Ser Gly Phe Glu 260 265 270 Lys Tyr Leu Ala Asp Gln Ala Lys Leu Ser Phe Glu Arg Lys Lys Gln 275 280 285 Gly Cys Asn Lys Arg Ala Ala Arg Lys Ala Pro Ala Pro Val Thr Pro 290 295 300 Pro Ala Pro Val Gln Asn Lys Asn Lys Pro Asn Lys Lys Ala Arg Val 305 310 315 320 Leu Ser Lys Lys Glu Glu Arg Leu Lys Lys His Ile Lys Lys Leu Gln 325 330 335 Lys Arg Ala Leu Gln Phe Gln Gly Lys Val Gly Leu Pro Lys Ala Arg 340 345 350 Arg Pro Trp Glu Ser Asp Met Arg Pro Glu Ala Glu Gly Asp Ser Glu 355 360 365 Gly Glu Glu Ser Glu Tyr Phe Pro Thr Glu Glu Glu Glu Glu Glu Glu 370 375 380 Asp Asp Glu Val Glu Gly Ala Glu Ala Asp Leu Ser Gly Asp Gly Thr 385 390 395 400 Asp Tyr Glu Leu Lys Pro Leu Pro Lys Gly Gly Lys Arg Gln Lys Lys 405 410 415 Val Pro Val Gln Glu Ile Asp Asp Asp Phe Phe Pro Ser Ser Gly Glu 420 425 430 Glu Ala Glu Ala Ala Ser Val Gly Glu Gly Gly Gly Gly Gly Arg Lys 435 440 445 Val Gly Arg Tyr Arg Asp Asp Gly Asp Glu Asp Tyr Tyr Lys Gln Arg 450 455 460 Leu Arg Arg Trp Asn Lys Leu Arg Leu Gln Asp Lys Glu Lys Arg Leu 465 470 475 480 Lys Leu Glu Asp Asp Ser Glu Glu Ser Asp Ala Glu Phe Asp Glu Gly 485 490 495 Phe Lys Val Pro Gly Phe Leu Phe Lys Lys Leu Phe Lys Tyr Gln Gln 500 505 510 Thr Gly Val Arg Trp Leu Trp Glu Leu His Cys Gln Gln Ala Gly Gly 515 520 525 Ile Leu Gly Asp Glu Met Gly Leu Gly Lys Thr Ile Gln Ile Ile Ala 530 535 540 Phe Leu Ala Gly Leu Ser Tyr Ser Lys Ile Arg Thr Arg Gly Ser Asn 545 550 555 560 Tyr Arg Phe Glu Gly Leu Gly Pro Thr Val Ile Val Cys Pro Thr Thr 565 570 575 Val Met His Gln Trp Val Lys Glu Phe His Thr Trp Trp Pro Pro Phe 580 585 590 Arg Val Ala Ile Leu His Glu Thr Gly Ser Tyr Thr His Lys Lys Glu 595 600 605 Lys Leu Ile Arg Asp Val Ala His Cys His Gly Ile Leu Ile Thr Ser 610 615 620 Tyr Ser Tyr Ile Arg Leu Met Gln Asp Asp Ile Ser Arg Tyr Asp Trp 625 630 635 640 His Tyr Val Ile Leu Asp Glu Gly His Lys Ile Arg Asn Pro Asn Ala 645 650 655 Ala Val Thr Leu Ala Cys Lys Gln Phe Arg Thr Pro His Arg Ile Ile 660 665 670 Leu Ser Gly Ser Pro Met Gln Asn Asn Leu Arg Glu Leu Trp Ser Leu 675 680 685 Phe Asp Phe Ile Phe Pro Gly Lys Leu Gly Thr Leu Pro Val Phe Met 690 695 700 Glu Gln Phe Ser Val Pro Ile Thr Met Gly Gly Tyr Ser Asn Ala Ser 705 710 715 720 Pro Val Gln Val Lys Thr Ala Tyr Lys Cys Ala Cys Val Leu Arg Asp 725 730 735 Thr Ile Asn Pro Tyr Leu Leu Arg Arg Met Lys Ser Asp Val Lys Met 740 745 750 Ser Leu Ser Leu Pro Asp Lys Asn Glu Gln Val Leu Phe Cys Arg Leu 755 760 765 Thr Asp Glu Gln His Lys Val Tyr Gln Asn Phe Val Asp Ser Lys Glu 770 775 780 Val Tyr Arg Ile Leu Asn Gly Glu Met Gln Ile Phe Ser Gly Leu Ile 785 790 795 800 Ala Leu Arg Lys Ile Cys Asn His Pro Asp Leu Phe Ser Gly Gly Pro 805 810 815 Lys Asn Leu Lys Gly Leu Pro Asp Asp Glu Leu Glu Glu Asp Gln Phe 820 825 830 Gly Tyr Trp Lys Arg Ser Gly Lys Met Ile Val Val Glu Ser Leu Leu 835 840 845 Lys Ile Trp His Lys Gln Gly Gln Arg Val Leu Leu Phe Ser Gln Ser 850 855 860 Arg Gln Met Leu Asp Ile Leu Glu Val Phe Leu Arg Ala Gln Lys Tyr 865 870 875 880 Thr Tyr Leu Lys Met Asp Gly Thr Thr Thr Ile Ala Ser Arg Gln Pro 885 890 895 Leu Ile Thr Arg Tyr Asn Glu Asp Thr Ser Ile Phe Val Phe Leu Leu 900 905 910 Thr Thr Arg Val Gly Gly Leu Gly Val Asn Leu Thr Gly Ala Asn Arg 915 920 925 Val Val Ile Tyr Asp Pro Asp Trp Asn Pro Ser Thr Asp Thr Gln Ala 930 935 940 Arg Glu Arg Ala Trp Arg Ile Gly Gln Lys Lys Gln Val Thr Val Tyr 945 950 955 960 Arg Leu Leu Thr Ala Gly Thr Ile Glu Glu Lys Ile Tyr His Arg Gln 965 970 975 Ile Phe Lys Gln Phe Leu Thr Asn Arg Val Leu Lys Asp Pro Lys Gln 980 985 990 Arg Arg Phe Phe Lys Ser Asn Asp Leu Tyr Glu Leu Phe Thr Leu Thr 995 1000 1005 Ser Pro Asp Ala Ser Gln Ser Thr Glu Thr Ser Ala Ile Phe Ala 1010 1015 1020 Gly Thr Gly Ser Asp Val Gln Thr Pro Lys Cys His Leu Lys Arg 1025 1030 1035 Arg Ile Gln Pro Ala Phe Gly Ala Asp His Asp Val Pro Lys Arg 1040 1045 1050 Lys Lys Phe Pro Ala Ser Asn Ile Ser Val Asn Asp Ala Thr Ser 1055 1060 1065 Ser Glu Glu Lys Ser Glu Ala Lys Gly Ala Glu Val Asn Ala Val 1070 1075 1080 Thr Ser Asn Arg Ser Asp Pro Leu Lys Asp Asp Pro His Met Ser 1085 1090 1095 Ser Asn Val Thr Ser Asn Asp Arg Leu Gly Glu Glu Thr Asn Ala 1100 1105 1110 Val Ser Gly Pro Glu Glu Leu Ser Val Ile Ser Gly Asn Gly Glu 1115 1120 1125 Cys Ser Asn Ser Ser Gly Thr Gly Lys Thr Ser Met Pro Ser Gly 1130 1135 1140 Asp Glu Ser Ile Asp Glu Lys Leu Gly Leu Ser Tyr Lys Arg Glu 1145 1150 1155 Arg Pro Ser Gln Ala Gln Thr Glu Ala Phe Trp Glu Asn Lys Gln 1160 1165 1170 Met Glu Asn Asn Phe Tyr Lys His Lys Ser Lys Thr Lys His His 1175 1180 1185 Ser Val Ala Glu Glu Glu Thr Leu Glu Lys His Leu Arg Pro Lys 1190 1195 1200 Gln Lys Pro Lys Asn Ser Lys His Cys Arg Asp Ala Lys Phe Glu 1205 1210 1215 Gly Thr Arg Ile Pro His Leu Val Lys Lys Arg Arg Tyr Gln Lys 1220 1225 1230 Gln Asp Ser Glu Asn Lys Ser Glu Ala Lys Glu Gln Ser Asn Asp 1235 1240 1245 Asp Tyr Val Leu Glu Lys Leu Phe Lys Lys Ser Val Gly Val His 1250 1255 1260 Ser Val Met Lys His Asp Ala Ile Met Asp Gly Ala Ser Pro Asp 1265 1270 1275 Tyr Val Leu Val Glu Ala Glu Ala Asn Arg Val Ala Gln Asp Ala 1280 1285 1290 Leu Lys Ala Leu Arg Leu Ser Arg Gln Arg Cys Leu Gly Ala Val 1295 1300 1305 Ser Gly Val Pro Thr Trp Thr Gly His Arg Gly Ile Ser Gly Ala 1310 1315 1320 Pro Ala Gly Lys Lys Ser Arg Phe Gly Lys Lys Arg Asn Ser Asn 1325 1330 1335 Phe Ser Val Gln His Pro Ser Ser Thr Ser Pro Thr Glu Lys Cys 1340 1345 1350 Gln Asp Gly Ile Met Lys Lys Glu Gly Lys Asp Asn Val Pro Glu 1355 1360 1365 His Phe Ser Gly Arg Ala Glu Asp Ala Asp Ser Ser Ser Gly Pro 1370 1375 1380 Leu Ala Ser Ser Ser Leu Leu Ala Lys Met Arg Ala Arg Asn His 1385 1390 1395 Leu Ile Leu Pro Glu Arg Leu Glu Ser Glu Ser Gly His Leu Gln 1400 1405 1410 Glu Ala Ser Ala Leu Leu Pro Thr Thr Glu His Asp Asp Leu Leu 1415 1420 1425 Val Glu Met Arg Asn Phe Ile Ala Phe Gln Ala His Thr Asp Gly 1430 1435 1440 Gln Ala Ser Thr Arg Glu Ile Leu Gln Glu Phe Glu Ser Lys Leu 1445 1450 1455 Ser Ala Ser Gln Ser Cys Val Phe Arg Glu Leu Leu Arg Asn Leu 1460 1465 1470 Cys Thr Phe His Arg Thr Ser Gly Gly Glu Gly Ile Trp Lys Leu 1475 1480 1485 Lys Pro Glu Tyr Cys 1490 <210> 691 <211> 1186 <212> PRT <213> Homo sapiens <400> 691 Met Gly Val Gln Gly Leu Trp Lys Leu Leu Glu Cys Ser Gly Arg Gln 1 5 10 15 Val Ser Pro Glu Ala Leu Glu Gly Lys Ile Leu Ala Val Asp Ile Ser 20 25 30 Ile Trp Leu Asn Gln Ala Leu Lys Gly Val Arg Asp Arg His Gly Asn 35 40 45 Ser Ile Glu Asn Pro His Leu Leu Thr Leu Phe His Arg Leu Cys Lys 50 55 60 Leu Leu Phe Phe Arg Ile Arg Pro Ile Phe Val Phe Asp Gly Asp Ala 65 70 75 80 Pro Leu Leu Lys Lys Gln Thr Leu Val Lys Arg Arg Gln Arg Lys Asp 85 90 95 Leu Ala Ser Ser Asp Ser Arg Lys Thr Thr Glu Lys Leu Leu Lys Thr 100 105 110 Phe Leu Lys Arg Gln Ala Ile Lys Thr Ala Phe Arg Ser Lys Arg Asp 115 120 125 Glu Ala Leu Pro Ser Leu Thr Gln Val Arg Arg Glu Asn Asp Leu Tyr 130 135 140 Val Leu Pro Pro Leu Gln Glu Glu Glu Lys His Ser Ser Glu Glu Glu 145 150 155 160 Asp Glu Lys Glu Trp Gln Glu Arg Met Asn Gln Lys Gln Ala Leu Gln 165 170 175 Glu Glu Phe Phe His Asn Pro Gln Ala Ile Asp Ile Glu Ser Glu Asp 180 185 190 Phe Ser Ser Leu Pro Pro Glu Val Lys His Glu Ile Leu Thr Asp Met 195 200 205 Lys Glu Phe Thr Lys Arg Arg Arg Thr Leu Phe Glu Ala Met Pro Glu 210 215 220 Glu Ser Asp Asp Phe Ser Gln Tyr Gln Leu Lys Gly Leu Leu Lys Lys 225 230 235 240 Asn Tyr Leu Asn Gln His Ile Glu His Val Gln Lys Glu Met Asn Gln 245 250 255 Gln His Ser Gly His Ile Arg Arg Gln Tyr Glu Asp Glu Gly Gly Phe 260 265 270 Leu Lys Glu Val Glu Ser Arg Arg Val Val Ser Glu Asp Thr Ser His 275 280 285 Tyr Ile Leu Ile Lys Gly Ile Gln Ala Lys Thr Val Ala Glu Val Asp 290 295 300 Ser Glu Ser Leu Pro Ser Ser Ser Lys Met His Gly Met Ser Phe Asp 305 310 315 320 Val Lys Ser Ser Pro Cys Glu Lys Leu Lys Thr Glu Lys Glu Pro Asp 325 330 335 Ala Thr Pro Pro Ser Pro Arg Thr Leu Leu Ala Met Gln Ala Ala Leu 340 345 350 Leu Gly Ser Ser Ser Glu Glu Glu Leu Glu Ser Glu Asn Arg Arg Gln 355 360 365 Ala Arg Gly Arg Asn Ala Pro Ala Ala Val Asp Glu Gly Ser Ile Ser 370 375 380 Pro Arg Thr Leu Ser Ala Ile Lys Arg Ala Leu Asp Asp Asp Glu Asp 385 390 395 400 Val Lys Val Cys Ala Gly Asp Asp Val Gln Thr Gly Gly Pro Gly Ala 405 410 415 Glu Glu Met Arg Ile Asn Ser Ser Thr Glu Asn Ser Asp Glu Gly Leu 420 425 430 Lys Val Arg Asp Gly Lys Gly Ile Pro Phe Thr Ala Thr Leu Ala Ser 435 440 445 Ser Ser Val Asn Ser Ala Glu Glu His Val Ala Ser Thr Asn Glu Gly 450 455 460 Arg Glu Pro Thr Asp Ser Val Pro Lys Glu Gln Met Ser Leu Val His 465 470 475 480 Val Gly Thr Glu Ala Phe Pro Ile Ser Asp Glu Ser Met Ile Lys Asp 485 490 495 Arg Lys Asp Arg Leu Pro Leu Glu Ser Ala Val Val Arg His Ser Asp 500 505 510 Ala Pro Gly Leu Pro Asn Gly Arg Glu Leu Thr Pro Ala Ser Pro Thr 515 520 525 Cys Thr Asn Ser Val Ser Lys Asn Glu Thr His Ala Glu Val Leu Glu 530 535 540 Gln Gln Asn Glu Leu Cys Pro Tyr Glu Ser Lys Phe Asp Ser Ser Leu 545 550 555 560 Leu Ser Ser Asp Asp Glu Thr Lys Cys Lys Pro Asn Ser Ala Ser Glu 565 570 575 Val Ile Gly Pro Val Ser Leu Gln Glu Thr Ser Ser Ile Val Ser Val 580 585 590 Pro Ser Glu Ala Val Asp Asn Val Glu Asn Val Val Ser Phe Asn Ala 595 600 605 Lys Glu His Glu Asn Phe Leu Glu Thr Ile Gln Glu Gln Gln Thr Thr 610 615 620 Glu Ser Ala Gly Gln Asp Leu Ile Ser Ile Pro Lys Ala Val Glu Pro 625 630 635 640 Met Glu Ile Asp Ser Glu Glu Ser Glu Ser Asp Gly Ser Phe Ile Glu 645 650 655 Val Gln Ser Val Ile Ser Asp Glu Glu Leu Gln Ala Glu Phe Pro Glu 660 665 670 Thr Ser Lys Pro Pro Ser Glu Gln Gly Glu Glu Glu Leu Val Gly Thr 675 680 685 Arg Glu Gly Glu Ala Pro Ala Glu Ser Glu Ser Leu Leu Arg Asp Asn 690 695 700 Ser Glu Arg Asp Asp Val Asp Gly Glu Pro Gln Glu Ala Glu Lys Asp 705 710 715 720 Ala Glu Asp Ser Leu His Glu Trp Gln Asp Ile Asn Leu Glu Glu Leu 725 730 735 Glu Thr Leu Glu Ser Asn Leu Leu Ala Gln Gln Asn Ser Leu Lys Ala 740 745 750 Gln Lys Gln Gln Gln Glu Arg Ile Ala Ala Thr Val Thr Gly Gln Met 755 760 765 Phe Leu Glu Ser Gln Glu Leu Leu Arg Leu Phe Gly Ile Pro Tyr Ile 770 775 780 Gln Ala Pro Met Glu Ala Glu Ala Gln Cys Ala Ile Leu Asp Leu Thr 785 790 795 800 Asp Gln Thr Ser Gly Thr Ile Thr Asp Asp Ser Asp Ile Trp Leu Phe 805 810 815 Gly Ala Arg His Val Tyr Arg Asn Phe Phe Asn Lys Asn Lys Phe Val 820 825 830 Glu Tyr Tyr Gln Tyr Val Asp Phe His Asn Gln Leu Gly Leu Asp Arg 835 840 845 Asn Lys Leu Ile Asn Leu Ala Tyr Leu Leu Gly Ser Asp Tyr Thr Glu 850 855 860 Gly Ile Pro Thr Val Gly Cys Val Thr Ala Met Glu Ile Leu Asn Glu 865 870 875 880 Phe Pro Gly His Gly Leu Glu Pro Leu Leu Lys Phe Ser Glu Trp Trp 885 890 895 His Glu Ala Gln Lys Asn Pro Lys Ile Arg Pro Asn Pro His Asp Thr 900 905 910 Lys Val Lys Lys Lys Leu Arg Thr Leu Gln Leu Thr Pro Gly Phe Pro 915 920 925 Asn Pro Ala Val Ala Glu Ala Tyr Leu Lys Pro Val Val Asp Asp Ser 930 935 940 Lys Gly Ser Phe Leu Trp Gly Lys Pro Asp Leu Asp Lys Ile Arg Glu 945 950 955 960 Phe Cys Gln Arg Tyr Phe Gly Trp Asn Arg Thr Lys Thr Asp Glu Ser 965 970 975 Leu Phe Pro Val Leu Lys Gln Leu Asp Ala Gln Gln Thr Gln Leu Arg 980 985 990 Ile Asp Ser Phe Phe Arg Leu Ala Gln Gln Glu Lys Glu Asp Ala Lys 995 1000 1005 Arg Ile Lys Ser Gln Arg Leu Asn Arg Ala Val Thr Cys Met Leu 1010 1015 1020 Arg Lys Glu Lys Glu Ala Ala Ala Ser Glu Ile Glu Ala Val Ser 1025 1030 1035 Val Ala Met Glu Lys Glu Phe Glu Leu Leu Asp Lys Ala Lys Arg 1040 1045 1050 Lys Thr Gln Lys Arg Gly Ile Thr Asn Thr Leu Glu Glu Ser Ser 1055 1060 1065 Ser Leu Lys Arg Lys Arg Leu Ser Asp Ser Lys Arg Lys Asn Thr 1070 1075 1080 Cys Gly Gly Phe Leu Gly Glu Thr Cys Leu Ser Glu Ser Ser Asp 1085 1090 1095 Gly Ser Ser Ser Glu His Ala Glu Ser Ser Ser Leu Met Asn Val 1100 1105 1110 Gln Arg Arg Thr Ala Ala Lys Glu Pro Lys Thr Ser Ala Ser Asp 1115 1120 1125 Ser Gln Asn Ser Val Lys Glu Ala Pro Val Lys Asn Gly Gly Ala 1130 1135 1140 Thr Thr Ser Ser Ser Ser Asp Ser Asp Asp Asp Gly Gly Lys Glu 1145 1150 1155 Lys Met Val Leu Val Thr Ala Arg Ser Val Phe Gly Lys Lys Arg 1160 1165 1170 Arg Lys Leu Arg Arg Ala Arg Gly Arg Lys Arg Lys Thr 1175 1180 1185 <210> 692 <211> 916 <212> PRT <213> Homo sapiens <400> 692 Met Glu Ser Gly Gln Pro Ala Arg Arg Ile Ala Met Ala Pro Leu Leu 1 5 10 15 Glu Tyr Glu Arg Gln Leu Val Leu Glu Leu Leu Asp Thr Asp Gly Leu 20 25 30 Val Val Cys Ala Arg Gly Leu Gly Ala Asp Arg Leu Leu Tyr His Phe 35 40 45 Leu Gln Leu His Cys His Pro Ala Cys Leu Val Leu Val Leu Asn Thr 50 55 60 Gln Pro Ala Glu Glu Glu Tyr Phe Ile Asn Gln Leu Lys Ile Glu Gly 65 70 75 80 Val Glu His Leu Pro Arg Arg Val Thr Asn Glu Ile Thr Ser Asn Ser 85 90 95 Arg Tyr Glu Val Tyr Thr Gln Gly Gly Val Ile Phe Ala Thr Ser Arg 100 105 110 Ile Leu Val Val Asp Phe Leu Thr Asp Arg Ile Pro Ser Asp Leu Ile 115 120 125 Thr Gly Ile Leu Val Tyr Arg Ala His Arg Ile Ile Glu Ser Cys Gln 130 135 140 Glu Ala Phe Ile Leu Arg Leu Phe Arg Gln Lys Asn Lys Arg Gly Phe 145 150 155 160 Ile Lys Ala Phe Thr Asp Asn Ala Val Ala Phe Asp Thr Gly Phe Cys 165 170 175 His Val Glu Arg Val Met Arg Asn Leu Phe Val Arg Lys Leu Tyr Leu 180 185 190 Trp Pro Arg Phe His Val Ala Val Asn Ser Phe Leu Glu Gln His Lys 195 200 205 Pro Glu Val Val Glu Ile His Val Ser Met Thr Pro Thr Met Leu Ala 210 215 220 Ile Gln Thr Ala Ile Leu Asp Ile Leu Asn Ala Cys Leu Lys Glu Leu 225 230 235 240 Lys Cys His Asn Pro Ser Leu Glu Val Glu Asp Leu Ser Leu Glu Asn 245 250 255 Ala Ile Gly Lys Pro Phe Asp Lys Thr Ile Arg His Tyr Leu Asp Pro 260 265 270 Leu Trp His Gln Leu Gly Ala Lys Thr Lys Ser Leu Val Gln Asp Leu 275 280 285 Lys Ile Leu Arg Thr Leu Leu Gln Tyr Leu Ser Gln Tyr Asp Cys Val 290 295 300 Thr Phe Leu Asn Leu Leu Glu Ser Leu Arg Ala Thr Glu Lys Ala Phe 305 310 315 320 Gly Gln Asn Ser Gly Trp Leu Phe Leu Asp Ser Ser Thr Ser Met Phe 325 330 335 Ile Asn Ala Arg Ala Arg Val Tyr His Leu Pro Asp Ala Lys Met Ser 340 345 350 Lys Lys Glu Lys Ile Ser Glu Lys Met Glu Ile Lys Glu Gly Glu Glu 355 360 365 Thr Lys Lys Glu Leu Val Leu Glu Ser Asn Pro Lys Trp Glu Ala Leu 370 375 380 Thr Glu Val Leu Lys Glu Ile Glu Ala Glu Asn Lys Glu Ser Glu Ala 385 390 395 400 Leu Gly Gly Pro Gly Gln Val Leu Ile Cys Ala Ser Asp Asp Arg Thr 405 410 415 Cys Ser Gln Leu Arg Asp Tyr Ile Thr Leu Gly Ala Glu Ala Phe Leu 420 425 430 Leu Arg Leu Tyr Arg Lys Thr Phe Glu Lys Asp Ser Lys Ala Glu Glu 435 440 445 Val Trp Met Lys Phe Arg Lys Glu Asp Ser Ser Lys Arg Ile Arg Lys 450 455 460 Ser His Lys Arg Pro Lys Asp Pro Gln Asn Lys Glu Arg Ala Ser Thr 465 470 475 480 Lys Glu Arg Thr Leu Lys Lys Lys Lys Arg Lys Leu Thr Leu Thr Gln 485 490 495 Met Val Gly Lys Pro Glu Glu Leu Glu Glu Glu Gly Asp Val Glu Glu 500 505 510 Gly Tyr Arg Arg Glu Ile Ser Ser Ser Pro Glu Ser Cys Pro Glu Glu 515 520 525 Ile Lys His Glu Glu Phe Asp Val Asn Leu Ser Ser Asp Ala Ala Phe 530 535 540 Gly Ile Leu Lys Glu Pro Leu Thr Ile Ile His Pro Leu Leu Gly Cys 545 550 555 560 Ser Asp Pro Tyr Ala Leu Thr Arg Val Leu His Glu Val Glu Pro Arg 565 570 575 Tyr Val Val Leu Tyr Asp Ala Glu Leu Thr Phe Val Arg Gln Leu Glu 580 585 590 Ile Tyr Arg Ala Ser Arg Pro Gly Lys Pro Leu Arg Val Tyr Phe Leu 595 600 605 Ile Tyr Gly Gly Ser Thr Glu Glu Gln Arg Tyr Leu Thr Ala Leu Arg 610 615 620 Lys Glu Lys Glu Ala Phe Glu Lys Leu Ile Arg Glu Lys Ala Ser Met 625 630 635 640 Val Val Pro Glu Glu Arg Glu Gly Arg Asp Glu Thr Asn Leu Asp Leu 645 650 655 Val Arg Gly Thr Ala Ser Ala Asp Val Ser Thr Asp Thr Arg Lys Ala 660 665 670 Gly Gly Gln Glu Gln Asn Gly Thr Gln Gln Ser Ile Val Val Asp Met 675 680 685 Arg Glu Phe Arg Ser Glu Leu Pro Ser Leu Ile His Arg Arg Gly Ile 690 695 700 Asp Ile Glu Pro Val Thr Leu Glu Val Gly Asp Tyr Ile Leu Thr Pro 705 710 715 720 Glu Met Cys Val Glu Arg Lys Ser Ile Ser Asp Leu Ile Gly Ser Leu 725 730 735 Asn Asn Gly Arg Leu Tyr Ser Gln Cys Ile Ser Met Ser Arg Tyr Tyr 740 745 750 Lys Arg Pro Val Leu Leu Ile Glu Phe Asp Pro Ser Lys Pro Phe Ser 755 760 765 Leu Thr Ser Arg Gly Ala Leu Phe Gln Glu Ile Ser Ser Asn Asp Ile 770 775 780 Ser Ser Lys Leu Thr Leu Leu Thr Leu His Phe Pro Arg Leu Arg Ile 785 790 795 800 Leu Trp Cys Pro Ser Pro His Ala Thr Ala Glu Leu Phe Glu Glu Leu 805 810 815 Lys Gln Ser Lys Pro Gln Pro Asp Ala Ala Thr Ala Leu Ala Ile Thr 820 825 830 Ala Asp Ser Glu Thr Leu Pro Glu Ser Glu Lys Tyr Asn Pro Gly Pro 835 840 845 Gln Asp Phe Leu Leu Lys Met Pro Gly Val Asn Ala Lys Asn Cys Arg 850 855 860 Ser Leu Met His His Val Lys Asn Ile Ala Glu Leu Ala Ala Leu Ser 865 870 875 880 Gln Asp Glu Leu Thr Ser Ile Leu Gly Asn Ala Ala Asn Ala Lys Gln 885 890 895 Leu Tyr Asp Phe Ile His Thr Ser Phe Ala Glu Val Val Ser Lys Gly 900 905 910 Lys Gly Lys Lys 915 <210> 693 <211> 1140 <212> PRT <213> Homo sapiens <400> 693 Met Ser Tyr Asn Tyr Val Val Thr Ala Gln Lys Pro Thr Ala Val Asn 1 5 10 15 Gly Cys Val Thr Gly His Phe Thr Ser Ala Glu Asp Leu Asn Leu Leu 20 25 30 Ile Ala Lys Asn Thr Arg Leu Glu Ile Tyr Val Val Thr Ala Glu Gly 35 40 45 Leu Arg Pro Val Lys Glu Val Gly Met Tyr Gly Lys Ile Ala Val Met 50 55 60 Glu Leu Phe Arg Pro Lys Gly Glu Ser Lys Asp Leu Leu Phe Ile Leu 65 70 75 80 Thr Ala Lys Tyr Asn Ala Cys Ile Leu Glu Tyr Lys Gln Ser Gly Glu 85 90 95 Ser Ile Asp Ile Ile Thr Arg Ala His Gly Asn Val Gln Asp Arg Ile 100 105 110 Gly Arg Pro Ser Glu Thr Gly Ile Ile Gly Ile Ile Asp Pro Glu Cys 115 120 125 Arg Met Ile Gly Leu Arg Leu Tyr Asp Gly Leu Phe Lys Val Ile Pro 130 135 140 Leu Asp Arg Asp Asn Lys Glu Leu Lys Ala Phe Asn Ile Arg Leu Glu 145 150 155 160 Glu Leu His Val Ile Asp Val Lys Phe Leu Tyr Gly Cys Gln Ala Pro 165 170 175 Thr Ile Cys Phe Val Tyr Gln Asp Pro Gln Gly Arg His Val Lys Thr 180 185 190 Tyr Glu Val Ser Leu Arg Glu Lys Glu Phe Asn Lys Gly Pro Trp Lys 195 200 205 Gln Glu Asn Val Glu Ala Glu Ala Ser Met Val Ile Ala Val Pro Glu 210 215 220 Pro Phe Gly Gly Ala Ile Ile Ile Gly Gln Glu Ser Ile Thr Tyr His 225 230 235 240 Asn Gly Asp Lys Tyr Leu Ala Ile Ala Pro Pro Ile Ile Lys Gln Ser 245 250 255 Thr Ile Val Cys His Asn Arg Val Asp Pro Asn Gly Ser Arg Tyr Leu 260 265 270 Leu Gly Asp Met Glu Gly Arg Leu Phe Met Leu Leu Leu Glu Lys Glu 275 280 285 Glu Gln Met Asp Gly Thr Val Thr Leu Lys Asp Leu Arg Val Glu Leu 290 295 300 Leu Gly Glu Thr Ser Ile Ala Glu Cys Leu Thr Tyr Leu Asp Asn Gly 305 310 315 320 Val Val Phe Val Gly Ser Arg Leu Gly Asp Ser Gln Leu Val Lys Leu 325 330 335 Asn Val Asp Ser Asn Glu Gln Gly Ser Tyr Val Val Ala Met Glu Thr 340 345 350 Phe Thr Asn Leu Gly Pro Ile Val Asp Met Cys Val Val Asp Leu Glu 355 360 365 Arg Gln Gly Gln Gly Gln Leu Val Thr Cys Ser Gly Ala Phe Lys Glu 370 375 380 Gly Ser Leu Arg Ile Ile Arg Asn Gly Ile Gly Ile His Glu His Ala 385 390 395 400 Ser Ile Asp Leu Pro Gly Ile Lys Gly Leu Trp Pro Leu Arg Ser Asp 405 410 415 Pro Asn Arg Glu Thr Tyr Asp Thr Leu Val Leu Ser Phe Val Gly Gln 420 425 430 Thr Arg Val Leu Met Leu Asn Gly Glu Glu Val Glu Glu Thr Glu Leu 435 440 445 Met Gly Phe Val Asp Asp Gln Gln Thr Phe Phe Cys Gly Asn Val Ala 450 455 460 His Gln Gln Leu Ile Gln Ile Thr Ser Ala Ser Val Arg Leu Val Ser 465 470 475 480 Gln Glu Pro Lys Ala Leu Val Ser Glu Trp Lys Glu Pro Gln Ala Lys 485 490 495 Asn Ile Ser Val Ala Ser Cys Asn Ser Ser Gln Val Val Val Ala Val 500 505 510 Gly Arg Ala Leu Tyr Tyr Leu Gln Ile His Pro Gln Glu Leu Arg Gln 515 520 525 Ile Ser His Thr Glu Met Glu His Glu Val Ala Cys Leu Asp Ile Thr 530 535 540 Pro Leu Gly Asp Ser Asn Gly Leu Ser Pro Leu Cys Ala Ile Gly Leu 545 550 555 560 Trp Thr Asp Ile Ser Ala Arg Ile Leu Lys Leu Pro Ser Phe Glu Leu 565 570 575 Leu His Lys Glu Met Leu Gly Gly Glu Ile Ile Pro Arg Ser Ile Leu 580 585 590 Met Thr Thr Phe Glu Ser Ser His Tyr Leu Leu Cys Ala Leu Gly Asp 595 600 605 Gly Ala Leu Phe Tyr Phe Gly Leu Asn Ile Glu Thr Gly Leu Leu Ser 610 615 620 Asp Arg Lys Lys Val Thr Leu Gly Thr Gln Pro Thr Val Leu Arg Thr 625 630 635 640 Phe Arg Ser Leu Ser Thr Thr Asn Val Phe Ala Cys Ser Asp Arg Pro 645 650 655 Thr Val Ile Tyr Ser Ser Asn His Lys Leu Val Phe Ser Asn Val Asn 660 665 670 Leu Lys Glu Val Asn Tyr Met Cys Pro Leu Asn Ser Asp Gly Tyr Pro 675 680 685 Asp Ser Leu Ala Leu Ala Asn Asn Ser Thr Leu Thr Ile Gly Thr Ile 690 695 700 Asp Glu Ile Gln Lys Leu His Ile Arg Thr Val Pro Leu Tyr Glu Ser 705 710 715 720 Pro Arg Lys Ile Cys Tyr Gln Glu Val Ser Gln Cys Phe Gly Val Leu 725 730 735 Ser Ser Arg Ile Glu Val Gln Asp Thr Ser Gly Gly Thr Thr Ala Leu 740 745 750 Arg Pro Ser Ala Ser Thr Gln Ala Leu Ser Ser Ser Val Ser Ser Ser 755 760 765 Lys Leu Phe Ser Ser Ser Thr Ala Pro His Glu Thr Ser Phe Gly Glu 770 775 780 Glu Val Glu Val His Asn Leu Leu Ile Ile Asp Gln His Thr Phe Glu 785 790 795 800 Val Leu His Ala His Gln Phe Leu Gln Asn Glu Tyr Ala Leu Ser Leu 805 810 815 Val Ser Cys Lys Leu Gly Lys Asp Pro Asn Thr Tyr Phe Ile Val Gly 820 825 830 Thr Ala Met Val Tyr Pro Glu Glu Ala Glu Pro Lys Gln Gly Arg Ile 835 840 845 Val Val Phe Gln Tyr Ser Asp Gly Lys Leu Gln Thr Val Ala Glu Lys 850 855 860 Glu Val Lys Gly Ala Val Tyr Ser Met Val Glu Phe Asn Gly Lys Leu 865 870 875 880 Leu Ala Ser Ile Asn Ser Thr Val Arg Leu Tyr Glu Trp Thr Thr Glu 885 890 895 Lys Asp Val Arg Thr Glu Cys Asn His Tyr Asn Asn Ile Met Ala Leu 900 905 910 Tyr Leu Lys Thr Lys Gly Asp Phe Ile Leu Val Gly Asp Leu Met Arg 915 920 925 Ser Val Leu Leu Leu Ala Tyr Lys Pro Met Glu Gly Asn Phe Glu Glu 930 935 940 Ile Ala Arg Asp Phe Asn Pro Asn Trp Met Ser Ala Val Glu Ile Leu 945 950 955 960 Asp Asp Asp Asn Phe Leu Gly Ala Glu Asn Ala Phe Asn Leu Phe Val 965 970 975 Cys Gln Lys Asp Ser Ala Ala Thr Thr Asp Glu Glu Arg Gln His Leu 980 985 990 Gln Glu Val Gly Leu Phe His Leu Gly Glu Phe Val Asn Val Phe Cys 995 1000 1005 His Gly Ser Leu Val Met Gln Asn Leu Gly Glu Thr Ser Thr Pro 1010 1015 1020 Thr Gln Gly Ser Val Leu Phe Gly Thr Val Asn Gly Met Ile Gly 1025 1030 1035 Leu Val Thr Ser Leu Ser Glu Ser Trp Tyr Asn Leu Leu Leu Asp 1040 1045 1050 Met Gln Asn Arg Leu Asn Lys Val Ile Lys Ser Val Gly Lys Ile 1055 1060 1065 Glu His Ser Phe Trp Arg Ser Phe His Thr Glu Arg Lys Thr Glu 1070 1075 1080 Pro Ala Thr Gly Phe Ile Asp Gly Asp Leu Ile Glu Ser Phe Leu 1085 1090 1095 Asp Ile Ser Arg Pro Lys Met Gln Glu Val Val Ala Asn Leu Gln 1100 1105 1110 Tyr Asp Asp Gly Ser Gly Met Lys Arg Glu Ala Thr Ala Asp Asp 1115 1120 1125 Leu Ile Lys Val Val Glu Glu Leu Thr Arg Ile His 1130 1135 1140 <210> 694 <211> 427 <212> PRT <213> Homo sapiens <400> 694 Met Ala Pro Lys Lys Arg Pro Glu Thr Gln Lys Thr Ser Glu Ile Val 1 5 10 15 Leu Arg Pro Arg Asn Lys Arg Ser Arg Ser Pro Leu Glu Leu Glu Pro 20 25 30 Glu Ala Lys Lys Leu Cys Ala Lys Gly Ser Gly Pro Ser Arg Arg Cys 35 40 45 Asp Ser Asp Cys Leu Trp Val Gly Leu Ala Gly Pro Gln Ile Leu Pro 50 55 60 Pro Cys Arg Ser Ile Val Arg Thr Leu His Gln His Lys Leu Gly Arg 65 70 75 80 Ala Ser Trp Pro Ser Val Gln Gln Gly Leu Gln Gln Ser Phe Leu His 85 90 95 Thr Leu Asp Ser Tyr Arg Ile Leu Gln Lys Ala Ala Pro Phe Asp Arg 100 105 110 Arg Ala Thr Ser Leu Ala Trp His Pro Thr His Pro Ser Thr Val Ala 115 120 125 Val Gly Ser Lys Gly Gly Asp Ile Met Leu Trp Asn Phe Gly Ile Lys 130 135 140 Asp Lys Pro Thr Phe Ile Lys Gly Ile Gly Ala Gly Gly Ser Ile Thr 145 150 155 160 Gly Leu Lys Phe Asn Pro Leu Asn Thr Asn Gln Phe Tyr Ala Ser Ser 165 170 175 Met Glu Gly Thr Thr Arg Leu Gln Asp Phe Lys Gly Asn Ile Leu Arg 180 185 190 Val Phe Ala Ser Ser Asp Thr Ile Asn Ile Trp Phe Cys Ser Leu Asp 195 200 205 Val Ser Ala Ser Ser Arg Met Val Val Thr Gly Asp Asn Val Gly Asn 210 215 220 Val Ile Leu Leu Asn Met Asp Gly Lys Glu Leu Trp Asn Leu Arg Met 225 230 235 240 His Lys Lys Lys Val Thr His Val Ala Leu Asn Pro Cys Cys Asp Trp 245 250 255 Phe Leu Ala Thr Ala Ser Val Asp Gln Thr Val Lys Ile Trp Asp Leu 260 265 270 Arg Gln Val Arg Gly Lys Ala Ser Phe Leu Tyr Ser Leu Pro His Arg 275 280 285 His Pro Val Asn Ala Ala Cys Phe Ser Pro Asp Gly Ala Arg Leu Leu 290 295 300 Thr Thr Asp Gln Lys Ser Glu Ile Arg Val Tyr Ser Ala Ser Gln Trp 305 310 315 320 Asp Cys Pro Leu Gly Leu Ile Pro His Pro His Arg His Phe Gln His 325 330 335 Leu Thr Pro Ile Lys Ala Ala Trp His Pro Arg Tyr Asn Leu Ile Val 340 345 350 Val Gly Arg Tyr Pro Asp Pro Asn Phe Lys Ser Cys Thr Pro Tyr Glu 355 360 365 Leu Arg Thr Ile Asp Val Phe Asp Gly Asn Ser Gly Lys Met Met Cys 370 375 380 Gln Leu Tyr Asp Pro Glu Ser Ser Gly Ile Ser Ser Leu Asn Glu Phe 385 390 395 400 Asn Pro Met Gly Asp Thr Leu Ala Ser Ala Met Gly Tyr His Ile Leu 405 410 415 Ile Trp Ser Gln Glu Glu Ala Arg Thr Arg Lys 420 425 <210> 695 <211> 855 <212> PRT <213> Homo sapiens <400> 695 Met Val Val Met Ala Arg Leu Ser Arg Pro Glu Arg Pro Asp Leu Val 1 5 10 15 Phe Glu Glu Glu Asp Leu Pro Tyr Glu Glu Glu Ile Met Arg Asn Gln 20 25 30 Phe Ser Val Lys Cys Trp Leu Arg Tyr Ile Glu Phe Lys Gln Gly Ala 35 40 45 Pro Lys Pro Arg Leu Asn Gln Leu Tyr Glu Arg Ala Leu Lys Leu Leu 50 55 60 Pro Cys Ser Thr Lys Leu Trp Tyr Arg Tyr Leu Lys Ala Arg Arg Ala 65 70 75 80 Gln Val Lys His Arg Cys Val Thr Asp Pro Ala Tyr Glu Asp Val Asn 85 90 95 Asn Cys His Glu Arg Ala Phe Val Phe Met His Lys Met Pro Arg Leu 100 105 110 Trp Leu Asp Tyr Cys Gln Phe Leu Met Asp Gln Gly Arg Val Thr His 115 120 125 Thr Arg Arg Thr Phe Asp Arg Ala Leu Arg Ala Leu Pro Ile Thr Gln 130 135 140 His Ser Arg Ile Trp Pro Leu Tyr Leu Arg Phe Leu Arg Ser His Pro 145 150 155 160 Leu Pro Glu Thr Ala Val Arg Gly Tyr Arg Arg Phe Leu Lys Leu Ser 165 170 175 Pro Glu Ser Ala Glu Glu Tyr Ile Glu Tyr Leu Lys Ser Ser Asp Arg 180 185 190 Leu Asp Glu Ala Ala Gln Arg Leu Ala Thr Val Val Asn Asp Glu Arg 195 200 205 Phe Val Ser Lys Ala Gly Lys Ser Asn Tyr Gln Leu Trp His Glu Leu 210 215 220 Cys Asp Leu Ile Ser Gln Asn Pro Asp Lys Val Gln Ser Leu Asn Val 225 230 235 240 Asp Ala Ile Ile Arg Gly Gly Leu Thr Arg Phe Thr Asp Gln Leu Gly 245 250 255 Lys Leu Trp Cys Ser Leu Ala Asp Tyr Tyr Ile Arg Ser Gly His Phe 260 265 270 Glu Lys Ala Arg Asp Val Tyr Glu Glu Ala Ile Arg Thr Val Met Thr 275 280 285 Val Arg Asp Phe Thr Gln Val Phe Asp Ser Tyr Ala Gln Phe Glu Glu 290 295 300 Ser Met Ile Ala Ala Lys Met Glu Thr Ala Arg Asn Trp Gly Ala Arg 305 310 315 320 Arg Arg Met Met Trp Thr Trp Ser Cys Ala Trp Pro Ala Ser Ser Ser 325 330 335 Ser Ser Ala Gly Gly Pro Cys Ser Ser Thr Ala Ser Cys Cys Ala Lys 340 345 350 Thr His Thr Thr Cys Thr Ser Gly Thr Ser Val Ser Pro Cys Thr Arg 355 360 365 Ala Ala Pro Gly Arg Ser Ser Thr Pro Thr Gln Arg Leu Cys Arg Arg 370 375 380 Trp Thr Pro Ser Arg Pro Gln Ala Ser Pro Thr Leu Cys Gly Trp Arg 385 390 395 400 Leu Pro Ser Phe Met Arg Thr Thr Asp Ser Leu Asp Asp Ala Arg Val 405 410 415 Ile Leu Glu Lys Ala Thr Lys Val Asn Phe Gln Ala Gly Trp Met Thr 420 425 430 Trp Gln Ala Cys Gly Val Ser Ala Glu Ser Trp Ser Ser Asp Thr Arg 435 440 445 Thr Thr Met Arg Pro Cys Gly Cys Cys Glu Arg Pro Arg Arg Cys Leu 450 455 460 Pro Ala Gly Ser Lys Tyr Phe Asp Gly Ser Glu Pro Val Gln Asn Arg 465 470 475 480 Val Tyr Lys Ser Leu Lys Val Trp Ser Met Leu Ala Asp Leu Glu Glu 485 490 495 Ser Leu Gly Thr Phe Gln Ser Thr Lys Ala Val Tyr Asp Arg Ile Leu 500 505 510 Asp Leu Arg Ile Ala Thr Pro Gln Ile Val Ile Asn Tyr Ala Met Phe 515 520 525 Leu Glu Glu His Lys Tyr Phe Glu Glu Ser Phe Lys Ala Tyr Glu Arg 530 535 540 Gly Ile Ser Leu Phe Lys Trp Pro Asn Val Ser Asp Ile Trp Ser Thr 545 550 555 560 Tyr Leu Thr Lys Phe Ile Ala Arg Tyr Gly Gly Arg Lys Leu Glu Arg 565 570 575 Ala Arg Asp Leu Phe Glu Gln Ala Leu Asp Gly Cys Pro Pro Lys Tyr 580 585 590 Ala Lys Thr Leu Tyr Leu Leu Tyr Ala Gln Leu Glu Glu Glu Trp Gly 595 600 605 Leu Ala Arg His Ala Met Ala Val Tyr Glu Arg Ala Thr Arg Ala Val 610 615 620 Glu Pro Ala Gln Gln Tyr Asp Met Phe Asn Ile Tyr Ile Lys Arg Ala 625 630 635 640 Ala Glu Ile Tyr Gly Val Thr His Thr Arg Gly Ile Tyr Gln Lys Ala 645 650 655 Ile Glu Val Leu Ser Asp Glu His Ala Arg Glu Met Cys Leu Arg Phe 660 665 670 Ala Asp Met Glu Cys Lys Leu Gly Lys Ile Asp Arg Ala Arg Ala Ile 675 680 685 Tyr Ser Phe Cys Ser Gln Ile Cys Asp Pro Arg Thr Thr Gly Ala Phe 690 695 700 Trp Gln Thr Trp Lys Asp Phe Glu Val Arg His Gly Asn Glu Asp Thr 705 710 715 720 Ile Lys Glu Met Leu Arg Ile Arg Arg Ser Val Gln Ala Thr Tyr Asn 725 730 735 Thr Gln Val Asn Phe Met Ala Ser Gln Met Leu Lys Val Ser Gly Ile 740 745 750 Pro Gly Thr Val Ser Asp Leu Ala Pro Gly Gln Ser Gly Met Asp Asp 755 760 765 Met Lys Leu Leu Glu Gln Arg Ala Glu Gln Leu Ala Ala Glu Ala Glu 770 775 780 Arg Asp Gln Pro Leu Arg Ala Gln Ser Lys Ile Leu Phe Val Arg Ser 785 790 795 800 Asp Ala Ser Arg Glu Glu Leu Ala Glu Leu Ala Gln Gln Val Asn Pro 805 810 815 Glu Glu Ile Gln Leu Gly Glu Asp Glu Asp Glu Asp Glu Met Asp Leu 820 825 830 Glu Pro Asn Glu Val Arg Leu Glu Gln Gln Ser Val Pro Ala Ala Val 835 840 845 Phe Gly Ser Leu Lys Glu Asp 850 855 <210> 696 <211> 304 <212> PRT <213> Homo sapiens <400> 696 Met Gly Val Phe Cys Leu Gly Pro Trp Gly Leu Gly Arg Lys Leu Arg 1 5 10 15 Thr Pro Gly Lys Gly Pro Leu Gln Leu Leu Ser Arg Leu Cys Gly Asp 20 25 30 His Leu Gln Ala Ile Pro Ala Lys Lys Ala Pro Ala Gly Gln Glu Glu 35 40 45 Pro Gly Thr Pro Pro Ser Ser Pro Leu Ser Ala Glu Gln Leu Asp Arg 50 55 60 Ile Gln Arg Asn Lys Ala Ala Ala Leu Leu Arg Leu Ala Ala Arg Asn 65 70 75 80 Val Pro Val Gly Phe Gly Glu Ser Trp Lys Lys His Leu Ser Gly Glu 85 90 95 Phe Gly Lys Pro Tyr Phe Ile Lys Leu Met Gly Phe Val Ala Glu Glu 100 105 110 Arg Lys His Tyr Thr Val Tyr Pro Pro Pro His Gln Val Phe Thr Trp 115 120 125 Thr Gln Met Cys Asp Ile Lys Asp Val Lys Val Val Ile Leu Gly Gln 130 135 140 Asp Pro Tyr His Gly Pro Asn Gln Ala His Gly Leu Cys Phe Ser Val 145 150 155 160 Gln Arg Pro Val Pro Pro Pro Pro Ser Leu Glu Asn Ile Tyr Lys Glu 165 170 175 Leu Ser Thr Asp Ile Glu Asp Phe Val His Pro Gly His Gly Asp Leu 180 185 190 Ser Gly Trp Ala Lys Gln Gly Val Leu Leu Leu Asn Ala Val Leu Thr 195 200 205 Val Arg Ala His Gln Ala Asn Ser His Lys Glu Arg Gly Trp Glu Gln 210 215 220 Phe Thr Asp Ala Val Val Ser Trp Leu Asn Gln Asn Ser Asn Gly Leu 225 230 235 240 Val Phe Leu Leu Trp Gly Ser Tyr Ala Gln Lys Lys Gly Ser Ala Ile 245 250 255 Asp Arg Lys Arg His His Val Leu Gln Thr Ala His Pro Ser Pro Leu 260 265 270 Ser Val Tyr Arg Gly Phe Phe Gly Cys Arg His Phe Ser Lys Thr Asn 275 280 285 Glu Leu Leu Gln Lys Ser Gly Lys Lys Pro Ile Asp Trp Lys Glu Leu 290 295 300 <210> 697 <211> 580 <212> PRT <213> Homo sapiens <400> 697 Met Gly Thr Thr Gly Leu Glu Ser Leu Ser Leu Gly Asp Arg Gly Ala 1 5 10 15 Ala Pro Thr Val Thr Ser Ser Glu Arg Leu Val Pro Asp Pro Pro Asn 20 25 30 Asp Leu Arg Lys Glu Asp Val Ala Met Glu Leu Glu Arg Val Gly Glu 35 40 45 Asp Glu Glu Gln Met Met Ile Lys Arg Ser Ser Glu Cys Asn Pro Leu 50 55 60 Leu Gln Glu Pro Ile Ala Ser Ala Gln Phe Gly Ala Thr Ala Gly Thr 65 70 75 80 Glu Cys Arg Lys Ser Val Pro Cys Gly Trp Glu Arg Val Val Lys Gln 85 90 95 Arg Leu Phe Gly Lys Thr Ala Gly Arg Phe Asp Val Tyr Phe Ile Ser 100 105 110 Pro Gln Gly Leu Lys Phe Arg Ser Lys Ser Ser Leu Ala Asn Tyr Leu 115 120 125 His Lys Asn Gly Glu Thr Ser Leu Lys Pro Glu Asp Phe Asp Phe Thr 130 135 140 Val Leu Ser Lys Arg Gly Ile Lys Ser Arg Tyr Lys Asp Cys Ser Met 145 150 155 160 Ala Ala Leu Thr Ser His Leu Gln Asn Gln Ser Asn Asn Ser Asn Trp 165 170 175 Asn Leu Arg Thr Arg Ser Lys Cys Lys Lys Asp Val Phe Met Pro Pro 180 185 190 Ser Ser Ser Ser Glu Leu Gln Glu Ser Arg Gly Leu Ser Asn Phe Thr 195 200 205 Ser Thr His Leu Leu Leu Lys Glu Asp Glu Gly Val Asp Asp Val Asn 210 215 220 Phe Arg Lys Val Arg Lys Pro Lys Gly Lys Val Thr Ile Leu Lys Gly 225 230 235 240 Ile Pro Ile Lys Lys Thr Lys Lys Gly Cys Arg Lys Ser Cys Ser Gly 245 250 255 Phe Val Gln Ser Asp Ser Lys Arg Glu Ser Val Cys Asn Lys Ala Asp 260 265 270 Ala Glu Ser Glu Pro Val Ala Gln Lys Ser Gln Leu Asp Arg Thr Val 275 280 285 Cys Ile Ser Asp Ala Gly Ala Cys Gly Glu Thr Leu Ser Val Thr Ser 290 295 300 Glu Glu Asn Ser Leu Val Lys Lys Lys Glu Arg Ser Leu Ser Ser Gly 305 310 315 320 Ser Asn Phe Cys Ser Glu Gln Lys Thr Ser Gly Ile Ile Asn Lys Phe 325 330 335 Cys Ser Ala Lys Asp Ser Glu His Asn Glu Lys Tyr Glu Asp Thr Phe 340 345 350 Leu Glu Ser Glu Glu Ile Gly Thr Lys Val Glu Val Val Glu Arg Lys 355 360 365 Glu His Leu His Thr Asp Ile Leu Lys Arg Gly Ser Glu Met Asp Asn 370 375 380 Asn Cys Ser Pro Thr Arg Lys Asp Phe Thr Gly Glu Lys Ile Phe Gln 385 390 395 400 Glu Asp Thr Ile Pro Arg Thr Gln Ile Glu Arg Arg Lys Thr Ser Leu 405 410 415 Tyr Phe Ser Ser Lys Tyr Asn Lys Glu Ala Leu Ser Pro Pro Arg Arg 420 425 430 Lys Ala Phe Lys Lys Trp Thr Pro Pro Arg Ser Pro Phe Asn Leu Val 435 440 445 Gln Glu Thr Leu Phe His Asp Pro Trp Lys Leu Leu Ile Ala Thr Ile 450 455 460 Phe Leu Asn Arg Thr Ser Gly Lys Met Ala Ile Pro Val Leu Trp Lys 465 470 475 480 Phe Leu Glu Lys Tyr Pro Ser Ala Glu Val Ala Arg Thr Ala Asp Trp 485 490 495 Arg Asp Val Ser Glu Leu Leu Lys Pro Leu Gly Leu Tyr Asp Leu Arg 500 505 510 Ala Lys Thr Ile Val Lys Phe Ser Asp Glu Tyr Leu Thr Lys Gln Trp 515 520 525 Lys Tyr Pro Ile Glu Leu His Gly Ile Gly Lys Tyr Gly Asn Asp Ser 530 535 540 Tyr Arg Ile Phe Cys Val Asn Glu Trp Lys Gln Val His Pro Glu Asp 545 550 555 560 His Lys Leu Asn Lys Tyr His Asp Trp Leu Trp Glu Asn His Glu Lys 565 570 575 Leu Ser Leu Ser 580 <210> 698 <211> 410 <212> PRT <213> Homo sapiens <400> 698 Met Glu Ala Glu Asn Ala Gly Ser Tyr Ser Leu Gln Gln Ala Gln Ala 1 5 10 15 Phe Tyr Thr Phe Pro Phe Gln Gln Leu Met Ala Glu Ala Pro Asn Met 20 25 30 Ala Val Val Asn Glu Gln Gln Met Pro Glu Glu Val Pro Ala Pro Ala 35 40 45 Pro Ala Gln Glu Pro Val Gln Glu Ala Pro Lys Gly Arg Lys Arg Lys 50 55 60 Pro Arg Thr Thr Glu Pro Lys Gln Pro Val Glu Pro Lys Lys Pro Val 65 70 75 80 Glu Ser Lys Lys Ser Gly Lys Ser Ala Lys Ser Lys Glu Lys Gln Glu 85 90 95 Lys Ile Thr Asp Thr Phe Lys Val Lys Arg Lys Val Asp Arg Phe Asn 100 105 110 Gly Val Ser Glu Ala Glu Leu Leu Thr Lys Thr Leu Pro Asp Ile Leu 115 120 125 Thr Phe Asn Leu Asp Ile Val Ile Ile Gly Ile Asn Pro Gly Leu Met 130 135 140 Ala Ala Tyr Lys Gly His His Tyr Pro Gly Pro Gly Asn His Phe Trp 145 150 155 160 Lys Cys Leu Phe Met Ser Gly Leu Ser Glu Val Gln Leu Asn His Met 165 170 175 Asp Asp His Thr Leu Pro Gly Lys Tyr Gly Ile Gly Phe Thr Asn Met 180 185 190 Val Glu Arg Thr Thr Pro Gly Ser Lys Asp Leu Ser Ser Lys Glu Phe 195 200 205 Arg Glu Gly Gly Arg Ile Leu Val Gln Lys Leu Gln Lys Tyr Gln Pro 210 215 220 Arg Ile Ala Val Phe Asn Gly Lys Cys Ile Tyr Glu Ile Phe Ser Lys 225 230 235 240 Glu Val Phe Gly Val Lys Val Lys Asn Leu Glu Phe Gly Leu Gln Pro 245 250 255 His Lys Ile Pro Asp Thr Glu Thr Leu Cys Tyr Gly Met Pro Ser Ser 260 265 270 Ser Ala Arg Cys Ala Gln Phe Pro Arg Ala Gln Asp Lys Val His Tyr 275 280 285 Tyr Ile Lys Leu Lys Asp Leu Arg Asp Gln Leu Lys Gly Ile Glu Arg 290 295 300 Asn Met Asp Val Gln Glu Val Gln Tyr Thr Phe Asp Leu Gln Leu Ala 305 310 315 320 Gln Glu Asp Ala Lys Lys Met Ala Val Lys Glu Glu Lys Tyr Asp Pro 325 330 335 Gly Tyr Glu Ala Ala Tyr Gly Gly Ala Tyr Gly Glu Asn Pro Cys Ser 340 345 350 Ser Glu Pro Cys Gly Phe Ser Ser Asn Gly Leu Ile Glu Ser Val Glu 355 360 365 Leu Arg Gly Glu Ser Ala Phe Ser Gly Ile Pro Asn Gly Gln Trp Met 370 375 380 Thr Gln Ser Phe Thr Asp Gln Ile Pro Ser Phe Ser Asn His Cys Gly 385 390 395 400 Thr Gln Glu Gln Glu Glu Glu Ser His Ala 405 410 <210> 699 <211> 312 <212> PRT <213> Homo sapiens <400> 699 Met Cys Ser Pro Gln Glu Ser Gly Met Thr Ala Leu Ser Ala Arg Met 1 5 10 15 Leu Thr Arg Ser Arg Ser Leu Gly Pro Gly Ala Gly Pro Arg Gly Cys 20 25 30 Arg Glu Glu Pro Gly Pro Leu Arg Arg Arg Glu Ala Ala Ala Glu Ala 35 40 45 Arg Lys Ser His Ser Pro Val Lys Arg Pro Arg Lys Ala Gln Arg Leu 50 55 60 Arg Val Ala Tyr Glu Gly Ser Asp Ser Glu Lys Gly Glu Gly Ala Glu 65 70 75 80 Pro Leu Lys Val Pro Val Trp Glu Pro Gln Asp Trp Gln Gln Gln Leu 85 90 95 Val Asn Ile Arg Ala Met Arg Asn Lys Lys Asp Ala Pro Val Asp His 100 105 110 Leu Gly Thr Glu His Cys Tyr Asp Ser Ser Ala Pro Pro Lys Val Arg 115 120 125 Arg Tyr Gln Val Leu Leu Ser Leu Met Leu Ser Ser Gln Thr Lys Asp 130 135 140 Gln Val Thr Ala Gly Ala Met Gln Arg Leu Arg Ala Arg Gly Leu Thr 145 150 155 160 Val Asp Ser Ile Leu Gln Thr Asp Asp Ala Thr Leu Gly Lys Leu Ile 165 170 175 Tyr Pro Val Gly Phe Trp Arg Ser Lys Val Lys Tyr Ile Lys Gln Thr 180 185 190 Ser Ala Ile Leu Gln Gln His Tyr Gly Gly Asp Ile Pro Ala Ser Val 195 200 205 Ala Glu Leu Val Ala Leu Pro Gly Val Gly Pro Lys Met Ala His Leu 210 215 220 Ala Met Ala Val Ala Trp Gly Thr Val Ser Gly Ile Ala Val Asp Thr 225 230 235 240 His Val His Arg Ile Ala Asn Arg Leu Arg Trp Thr Lys Lys Ala Thr 245 250 255 Lys Ser Pro Glu Glu Thr Arg Ala Ala Leu Glu Glu Trp Leu Pro Arg 260 265 270 Glu Leu Trp His Glu Ile Asn Gly Leu Leu Val Gly Phe Gly Gln Gln 275 280 285 Thr Cys Leu Pro Val His Pro Arg Cys His Ala Cys Leu Asn Gln Ala 290 295 300 Leu Cys Pro Ala Ala Gln Gly Leu 305 310 <210> 700 <211> 332 <212> PRT <213> Homo sapiens <400> 700 Met Pro Glu Gly Pro Leu Val Arg Lys Phe His His Leu Val Ser Pro 1 5 10 15 Phe Val Gly Gln Gln Val Val Lys Thr Gly Gly Ser Ser Lys Lys Leu 20 25 30 Gln Pro Ala Ser Leu Gln Ser Leu Trp Leu Gln Asp Thr Gln Val His 35 40 45 Gly Lys Lys Leu Phe Leu Arg Phe Asp Leu Asp Glu Glu Met Gly Pro 50 55 60 Pro Gly Ser Ser Pro Thr Pro Glu Pro Pro Gln Lys Glu Val Gln Lys 65 70 75 80 Glu Gly Ala Ala Asp Pro Lys Gln Val Gly Glu Pro Ser Gly Gln Lys 85 90 95 Thr Leu Asp Gly Ser Ser Arg Ser Ala Glu Leu Val Pro Gln Gly Glu 100 105 110 Asp Asp Ser Glu Tyr Leu Glu Arg Asp Ala Pro Ala Gly Asp Ala Gly 115 120 125 Arg Trp Leu Arg Val Ser Phe Gly Leu Phe Gly Ser Val Trp Val Asn 130 135 140 Asp Phe Ser Arg Ala Lys Lys Ala Asn Lys Arg Gly Asp Trp Arg Asp 145 150 155 160 Pro Ser Pro Arg Leu Val Leu His Phe Gly Gly Gly Gly Phe Leu Ala 165 170 175 Phe Tyr Asn Cys Gln Leu Ser Trp Ser Ser Ser Pro Val Val Thr Pro 180 185 190 Thr Cys Asp Ile Leu Ser Glu Lys Phe His Arg Gly Gln Ala Leu Glu 195 200 205 Ala Leu Gly Gln Ala Gln Pro Val Cys Tyr Thr Leu Leu Asp Gln Arg 210 215 220 Tyr Phe Ser Gly Leu Gly Asn Ile Ile Lys Asn Glu Ala Leu Tyr Arg 225 230 235 240 Ala Gly Ile His Pro Leu Ser Leu Gly Ser Val Leu Ser Ala Ser Arg 245 250 255 Arg Glu Val Leu Val Asp His Val Val Glu Phe Ser Thr Ala Trp Leu 260 265 270 Gln Gly Lys Phe Gln Gly Arg Pro Gln His Thr Gln Val Tyr Gln Lys 275 280 285 Glu Gln Cys Pro Ala Gly His Gln Val Met Lys Glu Ala Phe Gly Pro 290 295 300 Glu Asp Gly Leu Gln Arg Leu Thr Trp Trp Cys Pro Gln Cys Gln Pro 305 310 315 320 Gln Leu Ser Glu Glu Pro Glu Gln Cys Gln Phe Ser 325 330 <210> 701 <211> 605 <212> PRT <213> Homo sapiens <400> 701 Met Val Glu Gly Pro Gly Cys Thr Leu Asn Gly Glu Lys Ile Arg Ala 1 5 10 15 Arg Val Leu Pro Gly Gln Ala Val Thr Gly Val Arg Gly Ser Ala Leu 20 25 30 Arg Ser Pro Gln Gly Arg Ala Leu Arg Leu Ala Ala Ser Thr Val Val 35 40 45 Val Ser Pro Gln Ala Ala Ala Leu Asn Asn Asp Ser Ser Gln Asn Val 50 55 60 Leu Ser Leu Phe Asn Gly Tyr Val Tyr Ser Gly Val Glu Thr Leu Gly 65 70 75 80 Lys Glu Leu Phe Met Tyr Phe Gly Pro Lys Ala Leu Arg Ile His Phe 85 90 95 Gly Met Lys Gly Phe Ile Met Ile Asn Pro Leu Glu Tyr Lys Tyr Lys 100 105 110 Asn Gly Ala Ser Pro Val Leu Glu Val Gln Leu Thr Lys Asp Leu Ile 115 120 125 Cys Phe Phe Asp Ser Ser Val Glu Leu Arg Asn Ser Met Glu Ser Gln 130 135 140 Gln Arg Ile Arg Met Met Lys Glu Leu Asp Val Cys Ser Pro Glu Phe 145 150 155 160 Ser Phe Leu Arg Ala Glu Ser Glu Val Lys Lys Gln Lys Gly Arg Met 165 170 175 Leu Gly Asp Val Leu Met Asp Gln Asn Val Leu Pro Gly Val Gly Asn 180 185 190 Ile Ile Lys Asn Glu Ala Leu Phe Asp Ser Gly Leu His Pro Ala Val 195 200 205 Lys Val Cys Gln Leu Thr Asp Glu Gln Ile His His Leu Met Lys Met 210 215 220 Ile Arg Asp Phe Ser Ile Leu Phe Tyr Arg Cys Arg Lys Ala Gly Leu 225 230 235 240 Ala Leu Ser Lys His Tyr Lys Val Tyr Lys Arg Pro Asn Cys Gly Gln 245 250 255 Cys His Cys Arg Ile Thr Val Cys Arg Phe Gly Asp Asn Asn Arg Met 260 265 270 Thr Tyr Phe Cys Pro His Cys Gln Lys Glu Asn Pro Gln His Val Asp 275 280 285 Ile Cys Lys Leu Pro Thr Arg Asn Thr Ile Ile Ser Trp Thr Ser Ser 290 295 300 Arg Val Asp His Val Met Asp Ser Val Ala Arg Lys Ser Glu Glu His 305 310 315 320 Trp Thr Cys Val Val Cys Thr Leu Ile Asn Lys Pro Ser Ser Lys Ala 325 330 335 Cys Asp Ala Cys Leu Thr Ser Arg Pro Ile Asp Ser Val Leu Lys Ser 340 345 350 Glu Glu Asn Ser Thr Val Phe Ser His Leu Met Lys Tyr Pro Cys Asn 355 360 365 Thr Phe Gly Lys Pro His Thr Glu Val Lys Ile Asn Arg Lys Thr Ala 370 375 380 Phe Gly Thr Thr Thr Leu Val Leu Thr Asp Phe Ser Asn Lys Ser Ser 385 390 395 400 Thr Leu Glu Arg Lys Thr Lys Gln Asn Gln Ile Leu Asp Glu Glu Phe 405 410 415 Gln Asn Ser Pro Pro Ala Ser Val Cys Leu Asn Asp Ile Gln His Pro 420 425 430 Ser Lys Lys Thr Thr Asn Asp Ile Thr Gln Leu Ser Ser Lys Val Asn 435 440 445 Ile Ser Pro Thr Ile Ser Ser Glu Ser Lys Leu Phe Ser Pro Ala His 450 455 460 Lys Lys Pro Lys Thr Ala His Tyr Ser Ser Pro Glu Leu Lys Ser Cys 465 470 475 480 Asn Pro Gly Tyr Ser Asn Ser Glu Leu Gln Ile Asn Met Thr Asp Gly 485 490 495 Pro Arg Thr Leu Asn Pro Asp Ser Pro Arg Cys Ser Lys His Asn Arg 500 505 510 Leu Cys Ile Leu Arg Val Val Arg Lys Asp Gly Glu Asn Lys Gly Arg 515 520 525 Gln Phe Tyr Ala Cys Pro Leu Pro Arg Glu Ala Gln Cys Gly Phe Phe 530 535 540 Glu Trp Ala Asp Leu Ser Phe Pro Phe Cys Asn His Gly Lys Arg Ser 545 550 555 560 Thr Met Lys Thr Val Leu Lys Ile Gly Pro Asn Asn Gly Lys Asn Phe 565 570 575 Phe Val Cys Pro Leu Gly Lys Glu Lys Gln Cys Asn Phe Phe Gln Trp 580 585 590 Ala Glu Asn Gly Pro Gly Ile Lys Ile Ile Pro Gly Cys 595 600 605 <210> 702 <211> 518 <212> PRT <213> Homo sapiens <400> 702 Met Leu Arg Val Val Ser Trp Asn Ile Asn Gly Ile Arg Arg Pro Leu 1 5 10 15 Gln Gly Val Ala Asn Gln Glu Pro Ser Asn Cys Ala Ala Val Ala Val 20 25 30 Gly Arg Ile Leu Asp Glu Leu Asp Ala Asp Ile Val Cys Leu Gln Glu 35 40 45 Thr Lys Val Thr Arg Asp Ala Leu Thr Glu Pro Leu Ala Ile Val Glu 50 55 60 Gly Tyr Asn Ser Tyr Phe Ser Phe Ser Arg Asn Arg Ser Gly Tyr Ser 65 70 75 80 Gly Val Ala Thr Phe Cys Lys Asp Asn Ala Thr Pro Val Ala Ala Glu 85 90 95 Glu Gly Leu Ser Gly Leu Phe Ala Thr Gln Asn Gly Asp Val Gly Cys 100 105 110 Tyr Gly Asn Met Asp Glu Phe Thr Gln Glu Glu Leu Arg Ala Leu Asp 115 120 125 Ser Glu Gly Arg Ala Leu Leu Thr Gln His Lys Ile Arg Thr Trp Glu 130 135 140 Gly Lys Glu Lys Thr Leu Thr Leu Ile Asn Val Tyr Cys Pro His Ala 145 150 155 160 Asp Pro Gly Arg Pro Glu Arg Leu Val Phe Lys Met Arg Phe Tyr Arg 165 170 175 Leu Leu Gln Ile Arg Ala Glu Ala Leu Leu Ala Ala Gly Ser His Val 180 185 190 Ile Ile Leu Gly Asp Leu Asn Thr Ala His Arg Pro Ile Asp His Trp 195 200 205 Asp Ala Val Asn Leu Glu Cys Phe Glu Glu Asp Pro Gly Arg Lys Trp 210 215 220 Met Asp Ser Leu Leu Ser Asn Leu Gly Cys Gln Ser Ala Ser His Val 225 230 235 240 Gly Pro Phe Ile Asp Ser Tyr Arg Cys Phe Gln Pro Lys Gln Glu Gly 245 250 255 Ala Phe Thr Cys Trp Ser Ala Val Thr Gly Ala Arg His Leu Asn Tyr 260 265 270 Gly Ser Arg Leu Asp Tyr Val Leu Gly Asp Arg Thr Leu Val Ile Asp 275 280 285 Thr Phe Gln Ala Ser Phe Leu Leu Pro Glu Val Met Gly Ser Asp His 290 295 300 Cys Pro Val Gly Ala Val Leu Ser Val Ser Ser Val Pro Ala Lys Gln 305 310 315 320 Cys Pro Pro Leu Cys Thr Arg Phe Leu Pro Glu Phe Ala Gly Thr Gln 325 330 335 Leu Lys Ile Leu Arg Phe Leu Val Pro Leu Glu Gln Ser Pro Val Leu 340 345 350 Glu Gln Ser Thr Leu Gln His Asn Asn Gln Thr Arg Val Gln Thr Cys 355 360 365 Gln Asn Lys Ala Gln Val Arg Ser Thr Arg Pro Gln Pro Ser Gln Val 370 375 380 Gly Ser Ser Arg Gly Gln Lys Asn Leu Lys Ser Tyr Phe Gln Pro Ser 385 390 395 400 Pro Ser Cys Pro Gln Ala Ser Pro Asp Ile Glu Leu Pro Ser Leu Pro 405 410 415 Leu Met Ser Ala Leu Met Thr Pro Lys Thr Pro Glu Glu Lys Ala Val 420 425 430 Ala Lys Val Val Lys Gly Gln Ala Lys Thr Ser Glu Ala Lys Asp Glu 435 440 445 Lys Glu Leu Arg Thr Ser Phe Trp Lys Ser Val Leu Ala Gly Pro Leu 450 455 460 Arg Thr Pro Leu Cys Gly Gly His Arg Glu Pro Cys Val Met Arg Thr 465 470 475 480 Val Lys Lys Pro Gly Pro Asn Leu Gly Arg Arg Phe Tyr Met Cys Ala 485 490 495 Arg Pro Arg Gly Pro Pro Thr Asp Pro Ser Ser Arg Cys Asn Phe Phe 500 505 510 Leu Trp Ser Arg Pro Ser 515 <210> 703 <211> 1014 <212> PRT <213> Homo sapiens <400> 703 Met Ala Glu Ser Ser Asp Lys Leu Tyr Arg Val Glu Tyr Ala Lys Ser 1 5 10 15 Gly Arg Ala Ser Cys Lys Lys Cys Ser Glu Ser Ile Pro Lys Asp Ser 20 25 30 Leu Arg Met Ala Ile Met Val Gln Ser Pro Met Phe Asp Gly Lys Val 35 40 45 Pro His Trp Tyr His Phe Ser Cys Phe Trp Lys Val Gly His Ser Ile 50 55 60 Arg His Pro Asp Val Glu Val Asp Gly Phe Ser Glu Leu Arg Trp Asp 65 70 75 80 Asp Gln Gln Lys Val Lys Lys Thr Ala Glu Ala Gly Gly Val Thr Gly 85 90 95 Lys Gly Gln Asp Gly Ile Gly Ser Lys Ala Glu Lys Thr Leu Gly Asp 100 105 110 Phe Ala Ala Glu Tyr Ala Lys Ser Asn Arg Ser Thr Cys Lys Gly Cys 115 120 125 Met Glu Lys Ile Glu Lys Gly Gln Val Arg Leu Ser Lys Lys Met Val 130 135 140 Asp Pro Glu Lys Pro Gln Leu Gly Met Ile Asp Arg Trp Tyr His Pro 145 150 155 160 Gly Cys Phe Val Lys Asn Arg Glu Glu Leu Gly Phe Arg Pro Glu Tyr 165 170 175 Ser Ala Ser Gln Leu Lys Gly Phe Ser Leu Leu Ala Thr Glu Asp Lys 180 185 190 Glu Ala Leu Lys Lys Gln Leu Pro Gly Val Lys Ser Glu Gly Lys Arg 195 200 205 Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys Lys Ser 210 215 220 Lys Lys Glu Lys Asp Lys Asp Ser Lys Leu Glu Lys Ala Leu Lys Ala 225 230 235 240 Gln Asn Asp Leu Ile Trp Asn Ile Lys Asp Glu Leu Lys Lys Val Cys 245 250 255 Ser Thr Asn Asp Leu Lys Glu Leu Leu Ile Phe Asn Lys Gln Gln Val 260 265 270 Pro Ser Gly Glu Ser Ala Ile Leu Asp Arg Val Ala Asp Gly Met Val 275 280 285 Phe Gly Ala Leu Leu Pro Cys Glu Glu Cys Ser Gly Gln Leu Val Phe 290 295 300 Lys Ser Asp Ala Tyr Tyr Cys Thr Gly Asp Val Thr Ala Trp Thr Lys 305 310 315 320 Cys Met Val Lys Thr Gln Thr Pro Asn Arg Lys Glu Trp Val Thr Pro 325 330 335 Lys Glu Phe Arg Glu Ile Ser Tyr Leu Lys Lys Leu Lys Val Lys Lys 340 345 350 Gln Asp Arg Ile Phe Pro Pro Glu Thr Ser Ala Ser Val Ala Ala Thr 355 360 365 Pro Pro Pro Ser Thr Ala Ser Ala Pro Ala Ala Val Asn Ser Ser Ala 370 375 380 Ser Ala Asp Lys Pro Leu Ser Asn Met Lys Ile Leu Thr Leu Gly Lys 385 390 395 400 Leu Ser Arg Asn Lys Asp Glu Val Lys Ala Met Ile Glu Lys Leu Gly 405 410 415 Gly Lys Leu Thr Gly Thr Ala Asn Lys Ala Ser Leu Cys Ile Ser Thr 420 425 430 Lys Lys Glu Val Glu Lys Met Asn Lys Lys Met Glu Glu Val Lys Glu 435 440 445 Ala Asn Ile Arg Val Val Ser Glu Asp Phe Leu Gln Asp Val Ser Ala 450 455 460 Ser Thr Lys Ser Leu Gln Glu Leu Phe Leu Ala His Ile Leu Ser Pro 465 470 475 480 Trp Gly Ala Glu Val Lys Ala Glu Pro Val Glu Val Val Ala Pro Arg 485 490 495 Gly Lys Ser Gly Ala Ala Leu Ser Lys Lys Ser Lys Gly Gln Val Lys 500 505 510 Glu Glu Gly Ile Asn Lys Ser Glu Lys Arg Met Lys Leu Thr Leu Lys 515 520 525 Gly Gly Ala Ala Val Asp Pro Asp Ser Gly Leu Glu His Ser Ala His 530 535 540 Val Leu Glu Lys Gly Gly Lys Val Phe Ser Ala Thr Leu Gly Leu Val 545 550 555 560 Asp Ile Val Lys Gly Thr Asn Ser Tyr Tyr Lys Leu Gln Leu Leu Glu 565 570 575 Asp Asp Lys Glu Asn Arg Tyr Trp Ile Phe Arg Ser Trp Gly Arg Val 580 585 590 Gly Thr Val Ile Gly Ser Asn Lys Leu Glu Gln Met Pro Ser Lys Glu 595 600 605 Asp Ala Ile Glu Gln Phe Met Lys Leu Tyr Glu Glu Lys Thr Gly Asn 610 615 620 Ala Trp His Ser Lys Asn Phe Thr Lys Tyr Pro Lys Lys Phe Tyr Pro 625 630 635 640 Leu Glu Ile Asp Tyr Gly Gln Asp Glu Glu Ala Val Lys Lys Leu Thr 645 650 655 Val Asn Pro Gly Thr Lys Ser Lys Leu Pro Lys Pro Val Gln Asp Leu 660 665 670 Ile Lys Met Ile Phe Asp Val Glu Ser Met Lys Lys Ala Met Val Glu 675 680 685 Tyr Glu Ile Asp Leu Gln Lys Met Pro Leu Gly Lys Leu Ser Lys Arg 690 695 700 Gln Ile Gln Ala Ala Tyr Ser Ile Leu Ser Glu Val Gln Gln Ala Val 705 710 715 720 Ser Gln Gly Ser Ser Asp Ser Gln Ile Leu Asp Leu Ser Asn Arg Phe 725 730 735 Tyr Thr Leu Ile Pro His Asp Phe Gly Met Lys Lys Pro Pro Leu Leu 740 745 750 Asn Asn Ala Asp Ser Val Gln Ala Lys Val Glu Met Leu Asp Asn Leu 755 760 765 Leu Asp Ile Glu Val Ala Tyr Ser Leu Leu Arg Gly Gly Ser Asp Asp 770 775 780 Ser Ser Lys Asp Pro Ile Asp Val Asn Tyr Glu Lys Leu Lys Thr Asp 785 790 795 800 Ile Lys Val Val Asp Arg Asp Ser Glu Glu Ala Glu Ile Ile Arg Lys 805 810 815 Tyr Val Lys Asn Thr His Ala Thr Thr His Ser Ala Tyr Asp Leu Glu 820 825 830 Val Ile Asp Ile Phe Lys Ile Glu Arg Glu Gly Glu Cys Gln Arg Tyr 835 840 845 Lys Pro Phe Lys Gln Leu His Asn Arg Arg Leu Leu Trp His Gly Ser 850 855 860 Arg Thr Thr Asn Phe Ala Gly Ile Leu Ser Gln Gly Leu Arg Ile Ala 865 870 875 880 Pro Pro Glu Ala Pro Val Thr Gly Tyr Met Phe Gly Lys Gly Ile Tyr 885 890 895 Phe Ala Asp Met Val Ser Lys Ser Ala Asn Tyr Tyr His Thr Ser Gln 900 905 910 Gly Asp Pro Ile Gly Leu Ile Leu Leu Gly Glu Val Ala Leu Gly Asn 915 920 925 Met Tyr Glu Leu Lys His Ala Ser His Ile Ser Arg Leu Pro Lys Gly 930 935 940 Lys His Ser Val Lys Gly Leu Gly Lys Thr Thr Pro Asp Pro Ser Ala 945 950 955 960 Asn Ile Ser Leu Asp Gly Val Asp Val Pro Leu Gly Thr Gly Ile Ser 965 970 975 Ser Gly Val Ile Asp Thr Ser Leu Leu Tyr Asn Glu Tyr Ile Val Tyr 980 985 990 Asp Ile Ala Gln Val Asn Leu Lys Tyr Leu Leu Lys Leu Lys Phe Asn 995 1000 1005 Phe Lys Thr Ser Leu Trp 1010 <210> 704 <211> 521 <212> PRT <213> Homo sapiens <400> 704 Met Gly Glu Val Glu Ala Pro Gly Arg Leu Trp Leu Glu Ser Pro Pro 1 5 10 15 Gly Gly Ala Pro Pro Ile Phe Leu Pro Ser Asp Gly Gln Ala Leu Val 20 25 30 Leu Gly Arg Gly Pro Leu Thr Gln Val Thr Asp Arg Lys Cys Ser Arg 35 40 45 Thr Gln Val Glu Leu Val Ala Asp Pro Glu Thr Arg Thr Val Ala Val 50 55 60 Lys Gln Leu Gly Val Asn Pro Ser Thr Thr Gly Thr Gln Glu Leu Lys 65 70 75 80 Pro Gly Leu Glu Gly Ser Leu Gly Val Gly Asp Thr Leu Tyr Leu Val 85 90 95 Asn Gly Leu His Pro Leu Thr Leu Arg Trp Glu Glu Thr Arg Thr Pro 100 105 110 Glu Ser Gln Pro Asp Thr Pro Pro Gly Thr Pro Leu Val Ser Gln Asp 115 120 125 Glu Lys Arg Asp Ala Glu Leu Pro Lys Lys Arg Met Arg Lys Ser Asn 130 135 140 Pro Gly Trp Glu Asn Leu Glu Lys Leu Leu Val Phe Thr Ala Ala Gly 145 150 155 160 Val Lys Pro Gln Gly Lys Val Ala Gly Phe Asp Leu Asp Gly Thr Leu 165 170 175 Ile Thr Thr Arg Ser Gly Lys Val Phe Pro Thr Gly Pro Ser Asp Trp 180 185 190 Arg Ile Leu Tyr Pro Glu Ile Pro Arg Lys Leu Arg Glu Leu Glu Ala 195 200 205 Glu Gly Tyr Lys Leu Val Ile Phe Thr Asn Gln Met Ser Ile Gly Arg 210 215 220 Gly Lys Leu Pro Ala Glu Glu Phe Lys Ala Lys Val Glu Ala Val Val 225 230 235 240 Glu Lys Leu Gly Val Pro Phe Gln Val Leu Val Ala Thr His Ala Gly 245 250 255 Leu Tyr Arg Lys Pro Val Thr Gly Met Trp Asp His Leu Gln Glu Gln 260 265 270 Ala Asn Asp Gly Thr Pro Ile Ser Ile Gly Asp Ser Ile Phe Val Gly 275 280 285 Asp Ala Ala Gly Arg Pro Ala Asn Trp Ala Pro Gly Arg Lys Lys Lys 290 295 300 Asp Phe Ser Cys Ala Asp Arg Leu Phe Ala Leu Asn Leu Gly Leu Pro 305 310 315 320 Phe Ala Thr Pro Glu Glu Phe Phe Leu Lys Trp Pro Ala Ala Gly Phe 325 330 335 Glu Leu Pro Ala Phe Asp Pro Arg Thr Val Ser Arg Ser Gly Pro Leu 340 345 350 Cys Leu Pro Glu Ser Arg Ala Leu Leu Ser Ala Ser Pro Glu Val Val 355 360 365 Val Ala Val Gly Phe Pro Gly Ala Gly Lys Ser Thr Phe Leu Lys Lys 370 375 380 His Leu Val Ser Ala Gly Tyr Val His Val Asn Arg Asp Thr Leu Gly 385 390 395 400 Ser Trp Gln Arg Cys Val Thr Thr Cys Glu Thr Ala Leu Lys Gln Gly 405 410 415 Lys Arg Val Ala Ile Asp Asn Thr Asn Pro Asp Ala Ala Ser Arg Ala 420 425 430 Arg Tyr Val Gln Cys Ala Arg Ala Ala Gly Val Pro Cys Arg Cys Phe 435 440 445 Leu Phe Thr Ala Thr Leu Glu Gln Ala Arg His Asn Asn Arg Phe Arg 450 455 460 Glu Met Thr Asp Ser Ser His Ile Pro Val Ser Asp Met Val Met Tyr 465 470 475 480 Gly Tyr Arg Lys Gln Phe Glu Ala Pro Thr Leu Ala Glu Gly Phe Ser 485 490 495 Ala Ile Leu Glu Ile Pro Phe Arg Leu Trp Val Glu Pro Arg Leu Gly 500 505 510 Arg Leu Tyr Cys Gln Phe Ser Glu Gly 515 520 <210> 705 <211> 335 <212> PRT <213> Homo sapiens <400> 705 Met Ser Lys Arg Lys Ala Pro Gln Glu Thr Leu Asn Gly Gly Ile Thr 1 5 10 15 Asp Met Leu Thr Glu Leu Ala Asn Phe Glu Lys Asn Val Ser Gln Ala 20 25 30 Ile His Lys Tyr Asn Ala Tyr Arg Lys Ala Ala Ser Val Ile Ala Lys 35 40 45 Tyr Pro His Lys Ile Lys Ser Gly Ala Glu Ala Lys Lys Leu Pro Gly 50 55 60 Val Gly Thr Lys Ile Ala Glu Lys Ile Asp Glu Phe Leu Ala Thr Gly 65 70 75 80 Lys Leu Arg Lys Leu Glu Lys Ile Arg Gln Asp Asp Thr Ser Ser Ser 85 90 95 Ile Asn Phe Leu Thr Arg Val Ser Gly Ile Gly Pro Ser Ala Ala Arg 100 105 110 Lys Phe Val Asp Glu Gly Ile Lys Thr Leu Glu Asp Leu Arg Lys Asn 115 120 125 Glu Asp Lys Leu Asn His His Gln Arg Ile Gly Leu Lys Tyr Phe Gly 130 135 140 Asp Phe Glu Lys Arg Ile Pro Arg Glu Glu Met Leu Gln Met Gln Asp 145 150 155 160 Ile Val Leu Asn Glu Val Lys Lys Val Asp Ser Glu Tyr Ile Ala Thr 165 170 175 Val Cys Gly Ser Phe Arg Arg Gly Ala Glu Ser Ser Gly Asp Met Asp 180 185 190 Val Leu Leu Thr His Pro Ser Phe Thr Ser Glu Ser Thr Lys Gln Pro 195 200 205 Lys Leu Leu His Gln Val Val Glu Gln Leu Gln Lys Val His Phe Ile 210 215 220 Thr Asp Thr Leu Ser Lys Gly Glu Thr Lys Phe Met Gly Val Cys Gln 225 230 235 240 Leu Pro Ser Lys Asn Asp Glu Lys Glu Tyr Pro His Arg Arg Ile Asp 245 250 255 Ile Arg Leu Ile Pro Lys Asp Gln Tyr Tyr Cys Gly Val Leu Tyr Phe 260 265 270 Thr Gly Ser Asp Ile Phe Asn Lys Asn Met Arg Ala His Ala Leu Glu 275 280 285 Lys Gly Phe Thr Ile Asn Glu Tyr Thr Ile Arg Pro Leu Gly Val Thr 290 295 300 Gly Val Ala Gly Glu Pro Leu Pro Val Asp Ser Glu Lys Asp Ile Phe 305 310 315 320 Asp Tyr Ile Gln Trp Lys Tyr Arg Glu Pro Lys Asp Arg Ser Glu 325 330 335 <210> 706 <211> 934 <212> PRT <213> Homo sapiens <400> 706 Met Ala Val Gln Pro Lys Glu Thr Leu Gln Leu Glu Ser Ala Ala Glu 1 5 10 15 Val Gly Phe Val Arg Phe Phe Gln Gly Met Pro Glu Lys Pro Thr Thr 20 25 30 Thr Val Arg Leu Phe Asp Arg Gly Asp Phe Tyr Thr Ala His Gly Glu 35 40 45 Asp Ala Leu Leu Ala Ala Arg Glu Val Phe Lys Thr Gln Gly Val Ile 50 55 60 Lys Tyr Met Gly Pro Ala Gly Ala Lys Asn Leu Gln Ser Val Val Leu 65 70 75 80 Ser Lys Met Asn Phe Glu Ser Phe Val Lys Asp Leu Leu Leu Val Arg 85 90 95 Gln Tyr Arg Val Glu Val Tyr Lys Asn Arg Ala Gly Asn Lys Ala Ser 100 105 110 Lys Glu Asn Asp Trp Tyr Leu Ala Tyr Lys Ala Ser Pro Gly Asn Leu 115 120 125 Ser Gln Phe Glu Asp Ile Leu Phe Gly Asn Asn Asp Met Ser Ala Ser 130 135 140 Ile Gly Val Val Gly Val Lys Met Ser Ala Val Asp Gly Gln Arg Gln 145 150 155 160 Val Gly Val Gly Tyr Val Asp Ser Ile Gln Arg Lys Leu Gly Leu Cys 165 170 175 Glu Phe Pro Asp Asn Asp Gln Phe Ser Asn Leu Glu Ala Leu Leu Ile 180 185 190 Gln Ile Gly Pro Lys Glu Cys Val Leu Pro Gly Gly Glu Thr Ala Gly 195 200 205 Asp Met Gly Lys Leu Arg Gln Ile Ile Gln Arg Gly Gly Ile Leu Ile 210 215 220 Thr Glu Arg Lys Lys Ala Asp Phe Ser Thr Lys Asp Ile Tyr Gln Asp 225 230 235 240 Leu Asn Arg Leu Leu Lys Gly Lys Lys Gly Glu Gln Met Asn Ser Ala 245 250 255 Val Leu Pro Glu Met Glu Asn Gln Val Ala Val Ser Ser Leu Ser Ala 260 265 270 Val Ile Lys Phe Leu Glu Leu Leu Ser Asp Asp Ser Asn Phe Gly Gln 275 280 285 Phe Glu Leu Thr Thr Phe Asp Phe Ser Gln Tyr Met Lys Leu Asp Ile 290 295 300 Ala Ala Val Arg Ala Leu Asn Leu Phe Gln Gly Ser Val Glu Asp Thr 305 310 315 320 Thr Gly Ser Gln Ser Leu Ala Ala Leu Leu Asn Lys Cys Lys Thr Pro 325 330 335 Gln Gly Gln Arg Leu Val Asn Gln Trp Ile Lys Gln Pro Leu Met Asp 340 345 350 Lys Asn Arg Ile Glu Glu Arg Leu Asn Leu Val Glu Ala Phe Val Glu 355 360 365 Asp Ala Glu Leu Arg Gln Thr Leu Gln Glu Asp Leu Leu Arg Arg Phe 370 375 380 Pro Asp Leu Asn Arg Leu Ala Lys Lys Phe Gln Arg Gln Ala Ala Asn 385 390 395 400 Leu Gln Asp Cys Tyr Arg Leu Tyr Gln Gly Ile Asn Gln Leu Pro Asn 405 410 415 Val Ile Gln Ala Leu Glu Lys His Glu Gly Lys His Gln Lys Leu Leu 420 425 430 Leu Ala Val Phe Val Thr Pro Leu Thr Asp Leu Arg Ser Asp Phe Ser 435 440 445 Lys Phe Gln Glu Met Ile Glu Thr Thr Leu Asp Met Asp Gln Val Glu 450 455 460 Asn His Glu Phe Leu Val Lys Pro Ser Phe Asp Pro Asn Leu Ser Glu 465 470 475 480 Leu Arg Glu Ile Met Asn Asp Leu Glu Lys Lys Met Gln Ser Thr Leu 485 490 495 Ile Ser Ala Ala Arg Asp Leu Gly Leu Asp Pro Gly Lys Gln Ile Lys 500 505 510 Leu Asp Ser Ser Ala Gln Phe Gly Tyr Tyr Phe Arg Val Thr Cys Lys 515 520 525 Glu Glu Lys Val Leu Arg Asn Asn Lys Asn Phe Ser Thr Val Asp Ile 530 535 540 Gln Lys Asn Gly Val Lys Phe Thr Asn Ser Lys Leu Thr Ser Leu Asn 545 550 555 560 Glu Glu Tyr Thr Lys Asn Lys Thr Glu Tyr Glu Glu Ala Gln Asp Ala 565 570 575 Ile Val Lys Glu Ile Val Asn Ile Ser Ser Gly Tyr Val Glu Pro Met 580 585 590 Gln Thr Leu Asn Asp Val Leu Ala Gln Leu Asp Ala Val Val Ser Phe 595 600 605 Ala His Val Ser Asn Gly Ala Pro Val Pro Tyr Val Arg Pro Ala Ile 610 615 620 Leu Glu Lys Gly Gln Gly Arg Ile Ile Leu Lys Ala Ser Arg His Ala 625 630 635 640 Cys Val Glu Val Gln Asp Glu Ile Ala Phe Ile Pro Asn Asp Val Tyr 645 650 655 Phe Glu Lys Asp Lys Gln Met Phe His Ile Ile Thr Gly Pro Asn Met 660 665 670 Gly Gly Lys Ser Thr Tyr Ile Arg Gln Thr Gly Val Ile Val Leu Met 675 680 685 Ala Gln Ile Gly Cys Phe Val Pro Cys Glu Ser Ala Glu Val Ser Ile 690 695 700 Val Asp Cys Ile Leu Ala Arg Val Gly Ala Gly Asp Ser Gln Leu Lys 705 710 715 720 Gly Val Ser Thr Phe Met Ala Glu Met Leu Glu Thr Ala Ser Ile Leu 725 730 735 Arg Ser Ala Thr Lys Asp Ser Leu Ile Ile Ile Asp Glu Leu Gly Arg 740 745 750 Gly Thr Ser Thr Tyr Asp Gly Phe Gly Leu Ala Trp Ala Ile Ser Glu 755 760 765 Tyr Ile Ala Thr Lys Ile Gly Ala Phe Cys Met Phe Ala Thr His Phe 770 775 780 His Glu Leu Thr Ala Leu Ala Asn Gln Ile Pro Thr Val Asn Asn Leu 785 790 795 800 His Val Thr Ala Leu Thr Thr Glu Glu Thr Leu Thr Met Leu Tyr Gln 805 810 815 Val Lys Lys Gly Val Cys Asp Gln Ser Phe Gly Ile His Val Ala Glu 820 825 830 Leu Ala Asn Phe Pro Lys His Val Ile Glu Cys Ala Lys Gln Lys Ala 835 840 845 Leu Glu Leu Glu Glu Phe Gln Tyr Ile Gly Glu Ser Gln Gly Tyr Asp 850 855 860 Ile Met Glu Pro Ala Ala Lys Lys Cys Tyr Leu Glu Arg Glu Gln Gly 865 870 875 880 Glu Lys Ile Ile Gln Glu Phe Leu Ser Lys Val Lys Gln Met Pro Phe 885 890 895 Thr Glu Met Ser Glu Glu Asn Ile Thr Ile Lys Leu Lys Gln Leu Lys 900 905 910 Ala Glu Val Ile Ala Lys Asn Asn Ser Phe Val Asn Glu Ile Ile Ser 915 920 925 Arg Ile Lys Val Thr Thr 930 <210> 707 <211> 932 <212> PRT <213> Homo sapiens <400> 707 Met Lys Gln Leu Pro Ala Ala Thr Val Arg Leu Leu Ser Ser Ser Gln 1 5 10 15 Ile Ile Thr Ser Val Val Ser Val Val Lys Glu Leu Ile Glu Asn Ser 20 25 30 Leu Asp Ala Gly Ala Thr Ser Val Asp Val Lys Leu Glu Asn Tyr Gly 35 40 45 Phe Asp Lys Ile Glu Val Arg Asp Asn Gly Glu Gly Ile Lys Ala Val 50 55 60 Asp Ala Pro Val Met Ala Met Lys Tyr Tyr Thr Ser Lys Ile Asn Ser 65 70 75 80 His Glu Asp Leu Glu Asn Leu Thr Thr Tyr Gly Phe Arg Gly Glu Ala 85 90 95 Leu Gly Ser Ile Cys Cys Ile Ala Glu Val Leu Ile Thr Thr Arg Thr 100 105 110 Ala Ala Asp Asn Phe Ser Thr Gln Tyr Val Leu Asp Gly Ser Gly His 115 120 125 Ile Leu Ser Gln Lys Pro Ser His Leu Gly Gln Gly Thr Thr Val Thr 130 135 140 Ala Leu Arg Leu Phe Lys Asn Leu Pro Val Arg Lys Gln Phe Tyr Ser 145 150 155 160 Thr Ala Lys Lys Cys Lys Asp Glu Ile Lys Lys Ile Gln Asp Leu Leu 165 170 175 Met Ser Phe Gly Ile Leu Lys Pro Asp Leu Arg Ile Val Phe Val His 180 185 190 Asn Lys Ala Val Ile Trp Gln Lys Ser Arg Val Ser Asp His Lys Met 195 200 205 Ala Leu Met Ser Val Leu Gly Thr Ala Val Met Asn Asn Met Glu Ser 210 215 220 Phe Gln Tyr His Ser Glu Glu Ser Gln Ile Tyr Leu Ser Gly Phe Leu 225 230 235 240 Pro Lys Cys Asp Ala Asp His Ser Phe Thr Ser Leu Ser Thr Pro Glu 245 250 255 Arg Ser Phe Ile Phe Ile Asn Ser Arg Pro Val His Gln Lys Asp Ile 260 265 270 Leu Lys Leu Ile Arg His His Tyr Asn Leu Lys Cys Leu Lys Glu Ser 275 280 285 Thr Arg Leu Tyr Pro Val Phe Phe Leu Lys Ile Asp Val Pro Thr Ala 290 295 300 Asp Val Asp Val Asn Leu Thr Pro Asp Lys Ser Gln Val Leu Leu Gln 305 310 315 320 Asn Lys Glu Ser Val Leu Ile Ala Leu Glu Asn Leu Met Thr Thr Cys 325 330 335 Tyr Gly Pro Leu Pro Ser Thr Asn Ser Tyr Glu Asn Asn Lys Thr Asp 340 345 350 Val Ser Ala Ala Asp Ile Val Leu Ser Lys Thr Ala Glu Thr Asp Val 355 360 365 Leu Phe Asn Lys Val Glu Ser Ser Gly Lys Asn Tyr Ser Asn Val Asp 370 375 380 Thr Ser Val Ile Pro Phe Gln Asn Asp Met His Asn Asp Glu Ser Gly 385 390 395 400 Lys Asn Thr Asp Asp Cys Leu Asn His Gln Ile Ser Ile Gly Asp Phe 405 410 415 Gly Tyr Gly His Cys Ser Ser Glu Ile Ser Asn Ile Asp Lys Asn Thr 420 425 430 Lys Asn Ala Phe Gln Asp Ile Ser Met Ser Asn Val Ser Trp Glu Asn 435 440 445 Ser Gln Thr Glu Tyr Ser Lys Thr Cys Phe Ile Ser Ser Val Lys His 450 455 460 Thr Gln Ser Glu Asn Gly Asn Lys Asp His Ile Asp Glu Ser Gly Glu 465 470 475 480 Asn Glu Glu Glu Ala Gly Leu Glu Asn Ser Ser Glu Ile Ser Ala Asp 485 490 495 Glu Trp Ser Arg Gly Asn Ile Leu Lys Asn Ser Val Gly Glu Asn Ile 500 505 510 Glu Pro Val Lys Ile Leu Val Pro Glu Lys Ser Leu Pro Cys Lys Val 515 520 525 Ser Asn Asn Asn Tyr Pro Ile Pro Glu Gln Met Asn Leu Asn Glu Asp 530 535 540 Ser Cys Asn Lys Lys Ser Asn Val Ile Asp Asn Lys Ser Gly Lys Val 545 550 555 560 Thr Ala Tyr Asp Leu Leu Ser Asn Arg Val Ile Lys Lys Pro Met Ser 565 570 575 Ala Ser Ala Leu Phe Val Gln Asp His Arg Pro Gln Phe Leu Ile Glu 580 585 590 Asn Pro Lys Thr Ser Leu Glu Asp Ala Thr Leu Gln Ile Glu Glu Leu 595 600 605 Trp Lys Thr Leu Ser Glu Glu Glu Lys Leu Lys Tyr Glu Glu Lys Ala 610 615 620 Thr Lys Asp Leu Glu Arg Tyr Asn Ser Gln Met Lys Arg Ala Ile Glu 625 630 635 640 Gln Glu Ser Gln Met Ser Leu Lys Asp Gly Arg Lys Lys Ile Lys Pro 645 650 655 Thr Ser Ala Trp Asn Leu Ala Gln Lys His Lys Leu Lys Thr Ser Leu 660 665 670 Ser Asn Gln Pro Lys Leu Asp Glu Leu Leu Gln Ser Gln Ile Glu Lys 675 680 685 Arg Arg Ser Gln Asn Ile Lys Met Val Gln Ile Pro Phe Ser Met Lys 690 695 700 Asn Leu Lys Ile Asn Phe Lys Lys Gln Asn Lys Val Asp Leu Glu Glu 705 710 715 720 Lys Asp Glu Pro Cys Leu Ile His Asn Leu Arg Phe Pro Asp Ala Trp 725 730 735 Leu Met Thr Ser Lys Thr Glu Val Met Leu Leu Asn Pro Tyr Arg Val 740 745 750 Glu Glu Ala Leu Leu Phe Lys Arg Leu Leu Glu Asn His Lys Leu Pro 755 760 765 Ala Glu Pro Leu Glu Lys Pro Ile Met Leu Thr Glu Ser Leu Phe Asn 770 775 780 Gly Ser His Tyr Leu Asp Val Leu Tyr Lys Met Thr Ala Asp Asp Gln 785 790 795 800 Arg Tyr Ser Gly Ser Thr Tyr Leu Ser Asp Pro Arg Leu Thr Ala Asn 805 810 815 Gly Phe Lys Ile Lys Leu Ile Pro Gly Val Ser Ile Thr Glu Asn Tyr 820 825 830 Leu Glu Ile Glu Gly Met Ala Asn Cys Leu Pro Phe Tyr Gly Val Ala 835 840 845 Asp Leu Lys Glu Ile Leu Asn Ala Ile Leu Asn Arg Asn Ala Lys Glu 850 855 860 Val Tyr Glu Cys Arg Pro Arg Lys Val Ile Ser Tyr Leu Glu Gly Glu 865 870 875 880 Ala Val Arg Leu Ser Arg Gln Leu Pro Met Tyr Leu Ser Lys Glu Asp 885 890 895 Ile Gln Asp Ile Ile Tyr Arg Met Lys His Gln Phe Gly Asn Glu Ile 900 905 910 Lys Glu Cys Val His Gly Arg Pro Phe Phe His His Leu Thr Tyr Leu 915 920 925 Pro Glu Thr Thr 930 <210> 708 <211> 862 <212> PRT <213> Homo sapiens <400> 708 Met Glu Arg Ala Glu Ser Ser Ser Thr Glu Pro Ala Lys Ala Ile Lys 1 5 10 15 Pro Ile Asp Arg Lys Ser Val His Gln Ile Cys Ser Gly Gln Val Val 20 25 30 Leu Ser Leu Ser Thr Ala Val Lys Glu Leu Val Glu Asn Ser Leu Asp 35 40 45 Ala Gly Ala Thr Asn Ile Asp Leu Lys Leu Lys Asp Tyr Gly Val Asp 50 55 60 Leu Ile Glu Val Ser Asp Asn Gly Cys Gly Val Glu Glu Glu Asn Phe 65 70 75 80 Glu Gly Leu Thr Leu Lys His His Thr Ser Lys Ile Gln Glu Phe Ala 85 90 95 Asp Leu Thr Gln Val Glu Thr Phe Gly Phe Arg Gly Glu Ala Leu Ser 100 105 110 Ser Leu Cys Ala Leu Ser Asp Val Thr Ile Ser Thr Cys His Ala Ser 115 120 125 Ala Lys Val Gly Thr Arg Leu Met Phe Asp His Asn Gly Lys Ile Ile 130 135 140 Gln Lys Thr Pro Tyr Pro Arg Pro Arg Gly Thr Thr Val Ser Val Gln 145 150 155 160 Gln Leu Phe Ser Thr Leu Pro Val Arg His Lys Glu Phe Gln Arg Asn 165 170 175 Ile Lys Lys Glu Tyr Ala Lys Met Val Gln Val Leu His Ala Tyr Cys 180 185 190 Ile Ile Ser Ala Gly Ile Arg Val Ser Cys Thr Asn Gln Leu Gly Gln 195 200 205 Gly Lys Arg Gln Pro Val Val Cys Thr Gly Gly Ser Pro Ser Ile Lys 210 215 220 Glu Asn Ile Gly Ser Val Phe Gly Gln Lys Gln Leu Gln Ser Leu Ile 225 230 235 240 Pro Phe Val Gln Leu Pro Pro Ser Asp Ser Val Cys Glu Glu Tyr Gly 245 250 255 Leu Ser Cys Ser Asp Ala Leu His Asn Leu Phe Tyr Ile Ser Gly Phe 260 265 270 Ile Ser Gln Cys Thr His Gly Val Gly Arg Ser Ser Thr Asp Arg Gln 275 280 285 Phe Phe Phe Ile Asn Arg Arg Pro Cys Asp Pro Ala Lys Val Cys Arg 290 295 300 Leu Val Asn Glu Val Tyr His Met Tyr Asn Arg His Gln Tyr Pro Phe 305 310 315 320 Val Val Leu Asn Ile Ser Val Asp Ser Glu Cys Val Asp Ile Asn Val 325 330 335 Thr Pro Asp Lys Arg Gln Ile Leu Leu Gln Glu Glu Lys Leu Leu Leu 340 345 350 Ala Val Leu Lys Thr Ser Leu Ile Gly Met Phe Asp Ser Asp Val Asn 355 360 365 Lys Leu Asn Val Ser Gln Gln Pro Leu Leu Asp Val Glu Gly Asn Leu 370 375 380 Ile Lys Met His Ala Ala Asp Leu Glu Lys Pro Met Val Glu Lys Gln 385 390 395 400 Asp Gln Ser Pro Ser Leu Arg Thr Gly Glu Glu Lys Lys Asp Val Ser 405 410 415 Ile Ser Arg Leu Arg Glu Ala Phe Ser Leu Arg His Thr Thr Glu Asn 420 425 430 Lys Pro His Ser Pro Lys Thr Pro Glu Pro Arg Arg Ser Pro Leu Gly 435 440 445 Gln Lys Arg Gly Met Leu Ser Ser Ser Thr Ser Gly Ala Ile Ser Asp 450 455 460 Lys Gly Val Leu Arg Pro Gln Lys Glu Ala Val Ser Ser Ser His Gly 465 470 475 480 Pro Ser Asp Pro Thr Asp Arg Ala Glu Val Glu Lys Asp Ser Gly His 485 490 495 Gly Ser Thr Ser Val Asp Ser Glu Gly Phe Ser Ile Pro Asp Thr Gly 500 505 510 Ser His Cys Ser Ser Glu Tyr Ala Ala Ser Ser Pro Gly Asp Arg Gly 515 520 525 Ser Gln Glu His Val Asp Ser Gln Glu Lys Ala Pro Glu Thr Asp Asp 530 535 540 Ser Phe Ser Asp Val Asp Cys His Ser Asn Gln Glu Asp Thr Gly Cys 545 550 555 560 Lys Phe Arg Val Leu Pro Gln Pro Thr Asn Leu Ala Thr Pro Asn Thr 565 570 575 Lys Arg Phe Lys Lys Glu Glu Ile Leu Ser Ser Ser Asp Ile Cys Gln 580 585 590 Lys Leu Val Asn Thr Gln Asp Met Ser Ala Ser Gln Val Asp Val Ala 595 600 605 Val Lys Ile Asn Lys Lys Val Val Pro Leu Asp Phe Ser Met Ser Ser 610 615 620 Leu Ala Lys Arg Ile Lys Gln Leu His His Glu Ala Gln Gln Ser Glu 625 630 635 640 Gly Glu Gln Asn Tyr Arg Lys Phe Arg Ala Lys Ile Cys Pro Gly Glu 645 650 655 Asn Gln Ala Ala Glu Asp Glu Leu Arg Lys Glu Ile Ser Lys Thr Met 660 665 670 Phe Ala Glu Met Glu Ile Ile Gly Gln Phe Asn Leu Gly Phe Ile Ile 675 680 685 Thr Lys Leu Asn Glu Asp Ile Phe Ile Val Asp Gln His Ala Thr Asp 690 695 700 Glu Lys Tyr Asn Phe Glu Met Leu Gln Gln His Thr Val Leu Gln Gly 705 710 715 720 Gln Arg Leu Ile Ala Pro Gln Thr Leu Asn Leu Thr Ala Val Asn Glu 725 730 735 Ala Val Leu Ile Glu Asn Leu Glu Ile Phe Arg Lys Asn Gly Phe Asp 740 745 750 Phe Val Ile Asp Glu Asn Ala Pro Val Thr Glu Arg Ala Lys Leu Ile 755 760 765 Ser Leu Pro Thr Ser Lys Asn Trp Thr Phe Gly Pro Gln Asp Val Asp 770 775 780 Glu Leu Ile Phe Met Leu Ser Asp Ser Pro Gly Val Met Cys Arg Pro 785 790 795 800 Ser Arg Val Lys Gln Met Phe Ala Ser Arg Ala Cys Arg Lys Ser Val 805 810 815 Met Ile Gly Thr Ala Leu Asn Thr Ser Glu Met Lys Lys Leu Ile Thr 820 825 830 His Met Gly Glu Met Asp His Pro Trp Asn Cys Pro His Gly Arg Pro 835 840 845 Thr Met Arg His Ile Ala Asn Leu Gly Val Ile Ser Gln Asn 850 855 860 <210> 709 <211> 1429 <212> PRT <213> Homo sapiens <400> 709 Met Ile Lys Cys Leu Ser Val Glu Val Gln Ala Lys Leu Arg Ser Gly 1 5 10 15 Leu Ala Ile Ser Ser Leu Gly Gln Cys Val Glu Glu Leu Ala Leu Asn 20 25 30 Ser Ile Asp Ala Glu Ala Lys Cys Val Ala Val Arg Val Asn Met Glu 35 40 45 Thr Phe Gln Val Gln Val Ile Asp Asn Gly Phe Gly Met Gly Ser Asp 50 55 60 Asp Val Glu Lys Val Gly Asn Arg Tyr Phe Thr Ser Lys Cys His Ser 65 70 75 80 Val Gln Asp Leu Glu Asn Pro Arg Phe Tyr Gly Phe Arg Gly Glu Ala 85 90 95 Leu Ala Asn Ile Ala Asp Met Ala Ser Ala Val Glu Ile Ser Ser Lys 100 105 110 Lys Asn Arg Thr Met Lys Thr Phe Val Lys Leu Phe Gln Ser Gly Lys 115 120 125 Ala Leu Lys Ala Cys Glu Ala Asp Val Thr Arg Ala Ser Ala Gly Thr 130 135 140 Thr Val Thr Val Tyr Asn Leu Phe Tyr Gln Leu Pro Val Arg Arg Lys 145 150 155 160 Cys Met Asp Pro Arg Leu Glu Phe Glu Lys Val Arg Gln Arg Ile Glu 165 170 175 Ala Leu Ser Leu Met His Pro Ser Ile Ser Phe Ser Leu Arg Asn Asp 180 185 190 Val Ser Gly Ser Met Val Leu Gln Leu Pro Lys Thr Lys Asp Val Cys 195 200 205 Ser Arg Phe Cys Gln Ile Tyr Gly Leu Gly Lys Ser Gln Lys Leu Arg 210 215 220 Glu Ile Ser Phe Lys Tyr Lys Glu Phe Glu Leu Ser Gly Tyr Ile Ser 225 230 235 240 Ser Glu Ala His Tyr Asn Lys Asn Met Gln Phe Leu Phe Val Asn Lys 245 250 255 Arg Leu Val Leu Arg Thr Lys Leu His Lys Leu Ile Asp Phe Leu Leu 260 265 270 Arg Lys Glu Ser Ile Ile Cys Lys Pro Lys Asn Gly Pro Thr Ser Arg 275 280 285 Gln Met Asn Ser Ser Leu Arg His Arg Ser Thr Pro Glu Leu Tyr Gly 290 295 300 Ile Tyr Val Ile Asn Val Gln Cys Gln Phe Cys Glu Tyr Asp Val Cys 305 310 315 320 Met Glu Pro Ala Lys Thr Leu Ile Glu Phe Gln Asn Trp Asp Thr Leu 325 330 335 Leu Phe Cys Ile Gln Glu Gly Val Lys Met Phe Leu Lys Gln Glu Lys 340 345 350 Leu Phe Val Glu Leu Ser Gly Glu Asp Ile Lys Glu Phe Ser Glu Asp 355 360 365 Asn Gly Phe Ser Leu Phe Asp Ala Thr Leu Gln Lys Arg Val Thr Ser 370 375 380 Asp Glu Arg Ser Asn Phe Gln Glu Ala Cys Asn Asn Ile Leu Asp Ser 385 390 395 400 Tyr Glu Met Phe Asn Leu Gln Ser Lys Ala Val Lys Arg Lys Thr Thr 405 410 415 Ala Glu Asn Val Asn Thr Gln Ser Ser Arg Asp Ser Glu Ala Thr Arg 420 425 430 Lys Asn Thr Asn Asp Ala Phe Leu Tyr Ile Tyr Glu Ser Gly Gly Pro 435 440 445 Gly His Ser Lys Met Thr Glu Pro Ser Leu Gln Asn Lys Asp Ser Ser 450 455 460 Cys Ser Glu Ser Lys Met Leu Glu Gln Glu Thr Ile Val Ala Ser Glu 465 470 475 480 Ala Gly Glu Asn Glu Lys His Lys Lys Ser Phe Leu Glu Arg Ser Ser 485 490 495 Leu Glu Asn Pro Cys Gly Thr Ser Leu Glu Met Phe Leu Ser Pro Phe 500 505 510 Gln Thr Pro Cys His Phe Glu Glu Ser Gly Gln Asp Leu Glu Ile Trp 515 520 525 Lys Glu Ser Thr Thr Val Asn Gly Met Ala Ala Asn Ile Leu Lys Asn 530 535 540 Asn Arg Ile Gln Asn Gln Pro Lys Arg Phe Lys Asp Ala Thr Glu Val 545 550 555 560 Gly Cys Gln Pro Leu Pro Phe Ala Thr Thr Leu Trp Gly Val His Ser 565 570 575 Ala Gln Thr Glu Lys Glu Lys Lys Lys Glu Ser Ser Asn Cys Gly Arg 580 585 590 Arg Asn Val Phe Ser Tyr Gly Arg Val Lys Leu Cys Ser Thr Gly Phe 595 600 605 Ile Thr His Val Val Gln Asn Glu Lys Thr Lys Ser Thr Glu Thr Glu 610 615 620 His Ser Phe Lys Asn Tyr Val Arg Pro Gly Pro Thr Arg Ala Gln Glu 625 630 635 640 Thr Phe Gly Asn Arg Thr Arg His Ser Val Glu Thr Pro Asp Ile Lys 645 650 655 Asp Leu Ala Ser Thr Leu Ser Lys Glu Ser Gly Gln Leu Pro Asn Lys 660 665 670 Lys Asn Cys Arg Thr Asn Ile Ser Tyr Gly Leu Glu Asn Glu Pro Thr 675 680 685 Ala Thr Tyr Thr Met Phe Ser Ala Phe Gln Glu Gly Ser Lys Lys Ser 690 695 700 Gln Thr Asp Cys Ile Leu Ser Asp Thr Ser Pro Ser Phe Pro Trp Tyr 705 710 715 720 Arg His Val Ser Asn Asp Ser Arg Lys Thr Asp Lys Leu Ile Gly Phe 725 730 735 Ser Lys Pro Ile Val Arg Lys Lys Leu Ser Leu Ser Ser Gln Leu Gly 740 745 750 Ser Leu Glu Lys Phe Lys Arg Gln Tyr Gly Lys Val Glu Asn Pro Leu 755 760 765 Asp Thr Glu Val Glu Glu Ser Asn Gly Val Thr Thr Asn Leu Ser Leu 770 775 780 Gln Val Glu Pro Asp Ile Leu Leu Lys Asp Lys Asn Arg Leu Glu Asn 785 790 795 800 Ser Asp Val Cys Lys Ile Thr Thr Met Glu His Ser Asp Ser Asp Ser 805 810 815 Ser Cys Gln Pro Ala Ser His Ile Leu Asp Ser Glu Lys Phe Pro Phe 820 825 830 Ser Lys Asp Glu Asp Cys Leu Glu Gln Gln Met Pro Ser Leu Arg Glu 835 840 845 Ser Pro Met Thr Leu Lys Glu Leu Ser Leu Phe Asn Arg Lys Pro Leu 850 855 860 Asp Leu Glu Lys Ser Ser Glu Ser Leu Ala Ser Lys Leu Ser Arg Leu 865 870 875 880 Lys Gly Ser Glu Arg Glu Thr Gln Thr Met Gly Met Met Ser Arg Phe 885 890 895 Asn Glu Leu Pro Asn Ser Asp Ser Ser Arg Lys Asp Ser Lys Leu Cys 900 905 910 Ser Val Leu Thr Gln Asp Phe Cys Met Leu Phe Asn Asn Lys His Glu 915 920 925 Lys Thr Glu Asn Gly Val Ile Pro Thr Ser Asp Ser Ala Thr Gln Asp 930 935 940 Asn Ser Phe Asn Lys Asn Ser Lys Thr His Ser Asn Ser Asn Thr Thr 945 950 955 960 Glu Asn Cys Val Ile Ser Glu Thr Pro Leu Val Leu Pro Tyr Asn Asn 965 970 975 Ser Lys Val Thr Gly Lys Asp Ser Asp Val Leu Ile Arg Ala Ser Glu 980 985 990 Gln Gln Ile Gly Ser Leu Asp Ser Pro Ser Gly Met Leu Met Asn Pro 995 1000 1005 Val Glu Asp Ala Thr Gly Asp Gln Asn Gly Ile Cys Phe Gln Ser 1010 1015 1020 Glu Glu Ser Lys Ala Arg Ala Cys Ser Glu Thr Glu Glu Ser Asn 1025 1030 1035 Thr Cys Cys Ser Asp Trp Gln Arg His Phe Asp Val Ala Leu Gly 1040 1045 1050 Arg Met Val Tyr Val Asn Lys Met Thr Gly Leu Ser Thr Phe Ile 1055 1060 1065 Ala Pro Thr Glu Asp Ile Gln Ala Ala Cys Thr Lys Asp Leu Thr 1070 1075 1080 Thr Val Ala Val Asp Val Val Leu Glu Asn Gly Ser Gln Tyr Arg 1085 1090 1095 Cys Gln Pro Phe Arg Ser Asp Leu Val Leu Pro Phe Leu Pro Arg 1100 1105 1110 Ala Arg Ala Glu Arg Thr Val Met Arg Gln Asp Asn Arg Asp Thr 1115 1120 1125 Val Asp Asp Thr Val Ser Ser Glu Ser Leu Gln Ser Leu Phe Ser 1130 1135 1140 Glu Trp Asp Asn Pro Val Phe Ala Arg Tyr Pro Glu Val Ala Val 1145 1150 1155 Asp Val Ser Ser Gly Gln Ala Glu Ser Leu Ala Val Lys Ile His 1160 1165 1170 Asn Ile Leu Tyr Pro Tyr Arg Phe Thr Lys Gly Met Ile His Ser 1175 1180 1185 Met Gln Val Leu Gln Gln Val Asp Asn Lys Phe Ile Ala Cys Leu 1190 1195 1200 Met Ser Thr Lys Thr Glu Glu Asn Gly Glu Ala Asp Ser Tyr Glu 1205 1210 1215 Lys Gln Gln Ala Gln Gly Ser Gly Arg Lys Lys Leu Leu Ser Ser 1220 1225 1230 Thr Leu Ile Pro Pro Leu Glu Ile Thr Val Thr Glu Glu Gln Arg 1235 1240 1245 Arg Leu Leu Trp Cys Tyr His Lys Asn Leu Glu Asp Leu Gly Leu 1250 1255 1260 Glu Phe Val Phe Pro Asp Thr Ser Asp Ser Leu Val Leu Val Gly 1265 1270 1275 Lys Val Pro Leu Cys Phe Val Glu Arg Glu Ala Asn Glu Leu Arg 1280 1285 1290 Arg Gly Arg Ser Thr Val Thr Lys Ser Ile Val Glu Glu Phe Ile 1295 1300 1305 Arg Glu Gln Leu Glu Leu Leu Gln Thr Thr Gly Gly Ile Gln Gly 1310 1315 1320 Thr Leu Pro Leu Thr Val Gln Lys Val Leu Ala Ser Gln Ala Cys 1325 1330 1335 His Gly Ala Ile Lys Phe Asn Asp Gly Leu Ser Leu Gln Glu Ser 1340 1345 1350 Cys Arg Leu Ile Glu Ala Leu Ser Ser Cys Gln Leu Pro Phe Gln 1355 1360 1365 Cys Ala His Gly Arg Pro Ser Met Leu Pro Leu Ala Asp Ile Asp 1370 1375 1380 His Leu Glu Gln Glu Lys Gln Ile Lys Pro Asn Leu Thr Lys Leu 1385 1390 1395 Arg Lys Met Ala Gln Ala Trp Arg Leu Phe Gly Lys Ala Glu Cys 1400 1405 1410 Asp Thr Arg Gln Ser Leu Gln Gln Ser Met Pro Pro Cys Glu Pro 1415 1420 1425 Pro <210> 710 <211> 846 <212> PRT <213> Homo sapiens <400> 710 Met Gly Ile Gln Gly Leu Leu Gln Phe Ile Lys Glu Ala Ser Glu Pro 1 5 10 15 Ile His Val Arg Lys Tyr Lys Gly Gln Val Val Ala Val Asp Thr Tyr 20 25 30 Cys Trp Leu His Lys Gly Ala Ile Ala Cys Ala Glu Lys Leu Ala Lys 35 40 45 Gly Glu Pro Thr Asp Arg Tyr Val Gly Phe Cys Met Lys Phe Val Asn 50 55 60 Met Leu Leu Ser His Gly Ile Lys Pro Ile Leu Val Phe Asp Gly Cys 65 70 75 80 Thr Leu Pro Ser Lys Lys Glu Val Glu Arg Ser Arg Arg Glu Arg Arg 85 90 95 Gln Ala Asn Leu Leu Lys Gly Lys Gln Leu Leu Arg Glu Gly Lys Val 100 105 110 Ser Glu Ala Arg Glu Cys Phe Thr Arg Ser Ile Asn Ile Thr His Ala 115 120 125 Met Ala His Lys Val Ile Lys Ala Ala Arg Ser Gln Gly Val Asp Cys 130 135 140 Leu Val Ala Pro Tyr Glu Ala Asp Ala Gln Leu Ala Tyr Leu Asn Lys 145 150 155 160 Ala Gly Ile Val Gln Ala Ile Ile Thr Glu Asp Ser Asp Leu Leu Ala 165 170 175 Phe Gly Cys Lys Lys Val Ile Leu Lys Met Asp Gln Phe Gly Asn Gly 180 185 190 Leu Glu Ile Asp Gln Ala Arg Leu Gly Met Cys Arg Gln Leu Gly Asp 195 200 205 Val Phe Thr Glu Glu Lys Phe Arg Tyr Met Cys Ile Leu Ser Gly Cys 210 215 220 Asp Tyr Leu Ser Ser Leu Arg Gly Ile Gly Leu Ala Lys Ala Cys Lys 225 230 235 240 Val Leu Arg Leu Ala Asn Asn Pro Asp Ile Val Lys Val Ile Lys Lys 245 250 255 Ile Gly His Tyr Leu Lys Met Asn Ile Thr Val Pro Glu Asp Tyr Ile 260 265 270 Asn Gly Phe Ile Arg Ala Asn Asn Thr Phe Leu Tyr Gln Leu Val Phe 275 280 285 Asp Pro Ile Lys Arg Lys Leu Ile Pro Leu Asn Ala Tyr Glu Asp Asp 290 295 300 Val Asp Pro Glu Thr Leu Ser Tyr Ala Gly Gln Tyr Val Asp Asp Ser 305 310 315 320 Ile Ala Leu Gln Ile Ala Leu Gly Asn Lys Asp Ile Asn Thr Phe Glu 325 330 335 Gln Ile Asp Asp Tyr Asn Pro Asp Thr Ala Met Pro Ala His Ser Arg 340 345 350 Ser His Ser Trp Asp Asp Lys Thr Cys Gln Lys Ser Ala Asn Val Ser 355 360 365 Ser Ile Trp His Arg Asn Tyr Ser Pro Arg Pro Glu Ser Gly Thr Val 370 375 380 Ser Asp Ala Pro Gln Leu Lys Glu Asn Pro Ser Thr Val Gly Val Glu 385 390 395 400 Arg Val Ile Ser Thr Lys Gly Leu Asn Leu Pro Arg Lys Ser Ser Ile 405 410 415 Val Lys Arg Pro Arg Ser Ala Glu Leu Ser Glu Asp Asp Leu Leu Ser 420 425 430 Gln Tyr Ser Leu Ser Phe Thr Lys Lys Thr Lys Lys Asn Ser Ser Glu 435 440 445 Gly Asn Lys Ser Leu Ser Phe Ser Glu Val Phe Val Pro Asp Leu Val 450 455 460 Asn Gly Pro Thr Asn Lys Lys Ser Val Ser Thr Pro Pro Arg Thr Arg 465 470 475 480 Asn Lys Phe Ala Thr Phe Leu Gln Arg Lys Asn Glu Glu Ser Gly Ala 485 490 495 Val Val Val Pro Gly Thr Arg Ser Arg Phe Phe Cys Ser Ser Asp Ser 500 505 510 Thr Asp Cys Val Ser Asn Lys Val Ser Ile Gln Pro Leu Asp Glu Thr 515 520 525 Ala Val Thr Asp Lys Glu Asn Asn Leu His Glu Ser Glu Tyr Gly Asp 530 535 540 Gln Glu Gly Lys Arg Leu Val Asp Thr Asp Val Ala Arg Asn Ser Ser 545 550 555 560 Asp Asp Ile Pro Asn Asn His Ile Pro Gly Asp His Ile Pro Asp Lys 565 570 575 Ala Thr Val Phe Thr Asp Glu Glu Ser Tyr Ser Phe Glu Ser Ser Lys 580 585 590 Phe Thr Arg Thr Ile Ser Pro Pro Thr Leu Gly Thr Leu Arg Ser Cys 595 600 605 Phe Ser Trp Ser Gly Gly Leu Gly Asp Phe Ser Arg Thr Pro Ser Pro 610 615 620 Ser Pro Ser Thr Ala Leu Gln Gln Phe Arg Arg Lys Ser Asp Ser Pro 625 630 635 640 Thr Ser Leu Pro Glu Asn Asn Met Ser Asp Val Ser Gln Leu Lys Ser 645 650 655 Glu Glu Ser Ser Asp Asp Glu Ser His Pro Leu Arg Glu Gly Ala Cys 660 665 670 Ser Ser Gln Ser Gln Glu Ser Gly Glu Phe Ser Leu Gln Ser Ser Asn 675 680 685 Ala Ser Lys Leu Ser Gln Cys Ser Ser Lys Asp Ser Asp Ser Glu Glu 690 695 700 Ser Asp Cys Asn Ile Lys Leu Leu Asp Ser Gln Ser Asp Gln Thr Ser 705 710 715 720 Lys Leu Cys Leu Ser His Phe Ser Lys Lys Asp Thr Pro Leu Arg Asn 725 730 735 Lys Val Pro Gly Leu Tyr Lys Ser Ser Ser Ala Asp Ser Leu Ser Thr 740 745 750 Thr Lys Ile Lys Pro Leu Gly Pro Ala Arg Ala Ser Gly Leu Ser Lys 755 760 765 Lys Pro Ala Ser Ile Gln Lys Arg Lys His His Asn Ala Glu Asn Lys 770 775 780 Pro Gly Leu Gln Ile Lys Leu Asn Glu Leu Trp Lys Asn Phe Gly Phe 785 790 795 800 Lys Lys Asp Ser Glu Lys Leu Pro Pro Cys Lys Lys Pro Leu Ser Pro 805 810 815 Val Arg Asp Asn Ile Gln Leu Thr Pro Glu Ala Glu Glu Asp Ile Phe 820 825 830 Asn Lys Pro Glu Cys Gly Arg Val Gln Arg Ala Ile Phe Gln 835 840 845 <210> 711 <211> 715 <212> PRT <213> Homo sapiens <400> 711 Met Glu Leu Ala Asp Val Gly Ala Ala Ala Ser Ser Gln Gly Val His 1 5 10 15 Asp Gln Val Leu Pro Thr Pro Asn Ala Ser Ser Arg Val Ile Val His 20 25 30 Val Asp Leu Asp Cys Phe Tyr Ala Gln Val Glu Met Ile Ser Asn Pro 35 40 45 Glu Leu Lys Asp Lys Pro Leu Gly Val Gln Gln Lys Tyr Leu Val Val 50 55 60 Thr Cys Asn Tyr Glu Ala Arg Lys Leu Gly Val Lys Lys Leu Met Asn 65 70 75 80 Val Arg Asp Ala Lys Glu Lys Cys Pro Gln Leu Val Leu Val Asn Gly 85 90 95 Glu Asp Leu Thr Arg Tyr Arg Glu Met Ser Tyr Lys Val Thr Glu Leu 100 105 110 Leu Glu Glu Phe Ser Pro Val Val Glu Arg Leu Gly Phe Asp Glu Asn 115 120 125 Phe Val Asp Leu Thr Glu Met Val Glu Lys Arg Leu Gln Gln Leu Gln 130 135 140 Ser Asp Glu Leu Ser Ala Val Thr Val Ser Gly His Val Tyr Asn Asn 145 150 155 160 Gln Ser Ile Asn Leu Leu Asp Val Leu His Ile Arg Leu Leu Val Gly 165 170 175 Ser Gln Ile Ala Ala Glu Met Arg Glu Ala Met Tyr Asn Gln Leu Gly 180 185 190 Leu Thr Gly Cys Ala Gly Val Ala Ser Asn Lys Leu Leu Ala Lys Leu 195 200 205 Val Ser Gly Val Phe Lys Pro Asn Gln Gln Thr Val Leu Leu Pro Glu 210 215 220 Ser Cys Gln His Leu Ile His Ser Leu Asn His Ile Lys Glu Ile Pro 225 230 235 240 Gly Ile Gly Tyr Lys Thr Ala Lys Cys Leu Glu Ala Leu Gly Ile Asn 245 250 255 Ser Val Arg Asp Leu Gln Thr Phe Ser Pro Lys Ile Leu Glu Lys Glu 260 265 270 Leu Gly Ile Ser Val Ala Gln Arg Ile Gln Lys Leu Ser Phe Gly Glu 275 280 285 Asp Asn Ser Pro Val Ile Leu Ser Gly Pro Pro Gln Ser Phe Ser Glu 290 295 300 Glu Asp Ser Phe Lys Lys Cys Ser Ser Glu Val Glu Ala Lys Asn Lys 305 310 315 320 Ile Glu Glu Leu Leu Ala Ser Leu Leu Asn Arg Val Cys Gln Asp Gly 325 330 335 Arg Lys Pro His Thr Val Arg Leu Ile Ile Arg Arg Tyr Ser Ser Glu 340 345 350 Lys His Tyr Gly Arg Glu Ser Arg Gln Cys Pro Ile Pro Ser His Val 355 360 365 Ile Gln Lys Leu Gly Thr Gly Asn Tyr Asp Val Met Thr Pro Met Val 370 375 380 Asp Ile Leu Met Lys Leu Phe Arg Asn Met Val Asn Val Lys Met Pro 385 390 395 400 Phe His Leu Thr Leu Leu Ser Val Cys Phe Cys Asn Leu Lys Ala Leu 405 410 415 Asn Thr Ala Lys Lys Gly Leu Ile Asp Tyr Tyr Leu Met Pro Ser Leu 420 425 430 Ser Thr Thr Ser Arg Ser Gly Lys His Ser Phe Lys Met Lys Asp Thr 435 440 445 His Met Glu Asp Phe Pro Lys Asp Lys Glu Thr Asn Arg Asp Phe Leu 450 455 460 Pro Ser Gly Arg Ile Glu Ser Thr Arg Thr Arg Glu Ser Pro Leu Asp 465 470 475 480 Thr Thr Asn Phe Ser Lys Glu Lys Asp Ile Asn Glu Phe Pro Leu Cys 485 490 495 Ser Leu Pro Glu Gly Val Asp Gln Glu Val Phe Lys Gln Leu Pro Val 500 505 510 Asp Ile Gln Glu Glu Ile Leu Ser Gly Lys Ser Arg Glu Lys Phe Gln 515 520 525 Gly Lys Gly Ser Val Ser Cys Pro Leu His Ala Ser Arg Gly Val Leu 530 535 540 Ser Phe Phe Ser Lys Lys Gln Met Gln Asp Ile Pro Ile Asn Pro Arg 545 550 555 560 Asp His Leu Ser Ser Ser Lys Gln Val Ser Ser Val Ser Pro Cys Glu 565 570 575 Pro Gly Thr Ser Gly Phe Asn Ser Ser Ser Ser Ser Tyr Met Ser Ser 580 585 590 Gln Lys Asp Tyr Ser Tyr Tyr Leu Asp Asn Arg Leu Lys Asp Glu Arg 595 600 605 Ile Ser Gln Gly Pro Lys Glu Pro Gln Gly Phe His Phe Thr Asn Ser 610 615 620 Asn Pro Ala Val Ser Ala Phe His Ser Phe Pro Asn Leu Gln Ser Glu 625 630 635 640 Gln Leu Phe Ser Arg Asn His Thr Thr Asp Ser His Lys Gln Thr Val 645 650 655 Ala Thr Asp Ser His Glu Gly Leu Thr Glu Asn Arg Glu Pro Asp Ser 660 665 670 Val Asp Glu Lys Ile Thr Phe Pro Ser Asp Ile Asp Pro Gln Val Phe 675 680 685 Tyr Glu Leu Pro Glu Ala Val Gln Lys Glu Leu Leu Ala Glu Trp Lys 690 695 700 Arg Thr Gly Ser Asp Phe His Ile Gly His Lys 705 710 715 <210> 712 <211> 339 <212> PRT <213> Homo sapiens <400> 712 Met Ala Met Gln Met Gln Leu Glu Ala Asn Ala Asp Thr Ser Val Glu 1 5 10 15 Glu Glu Ser Phe Gly Pro Gln Pro Ile Ser Arg Leu Glu Gln Cys Gly 20 25 30 Ile Asn Ala Asn Asp Val Lys Lys Leu Glu Glu Ala Gly Phe His Thr 35 40 45 Val Glu Ala Val Ala Tyr Ala Pro Lys Lys Glu Leu Ile Asn Ile Lys 50 55 60 Gly Ile Ser Glu Ala Lys Ala Asp Lys Ile Leu Ala Glu Ala Ala Lys 65 70 75 80 Leu Val Pro Met Gly Phe Thr Thr Ala Thr Glu Phe His Gln Arg Arg 85 90 95 Ser Glu Ile Ile Gln Ile Thr Thr Gly Ser Lys Glu Leu Asp Lys Leu 100 105 110 Leu Gln Gly Gly Ile Glu Thr Gly Ser Ile Thr Glu Met Phe Gly Glu 115 120 125 Phe Arg Thr Gly Lys Thr Gln Ile Cys His Thr Leu Ala Val Thr Cys 130 135 140 Gln Leu Pro Ile Asp Arg Gly Gly Gly Glu Gly Lys Ala Met Tyr Ile 145 150 155 160 Asp Thr Glu Gly Thr Phe Arg Pro Glu Arg Leu Leu Ala Val Ala Glu 165 170 175 Arg Tyr Gly Leu Ser Gly Ser Asp Val Leu Asp Asn Val Ala Tyr Ala 180 185 190 Arg Ala Phe Asn Thr Asp His Gln Thr Gln Leu Leu Tyr Gln Ala Ser 195 200 205 Ala Met Met Val Glu Ser Arg Tyr Ala Leu Leu Ile Val Asp Ser Ala 210 215 220 Thr Ala Leu Tyr Arg Thr Asp Tyr Ser Gly Arg Gly Glu Leu Ser Ala 225 230 235 240 Arg Gln Met His Leu Ala Arg Phe Leu Arg Met Leu Leu Arg Leu Ala 245 250 255 Asp Glu Phe Gly Val Ala Val Val Ile Thr Asn Gln Val Val Ala Gln 260 265 270 Val Asp Gly Ala Ala Met Phe Ala Ala Asp Pro Lys Lys Pro Ile Gly 275 280 285 Gly Asn Ile Ile Ala His Ala Ser Thr Thr Arg Leu Tyr Leu Arg Lys 290 295 300 Gly Arg Gly Glu Thr Arg Ile Cys Lys Ile Tyr Asp Ser Pro Cys Leu 305 310 315 320 Pro Glu Ala Glu Ala Met Phe Ala Ile Asn Ala Asp Gly Val Gly Asp 325 330 335 Ala Lys Asp <210> 713 <211> 328 <212> PRT <213> Homo sapiens <400> 713 Met Gly Val Leu Arg Val Gly Leu Cys Pro Gly Leu Thr Glu Glu Met 1 5 10 15 Ile Gln Leu Leu Arg Ser His Arg Ile Lys Thr Val Val Asp Leu Val 20 25 30 Ser Ala Asp Leu Glu Glu Val Ala Gln Lys Cys Gly Leu Ser Tyr Lys 35 40 45 Ala Leu Val Ala Leu Arg Arg Val Leu Leu Ala Gln Phe Ser Ala Phe 50 55 60 Pro Val Asn Gly Ala Asp Leu His Glu Glu Leu Lys Thr Ser Thr Ala 65 70 75 80 Ile Leu Ser Thr Gly Ile Gly Ser Leu Asp Lys Leu Leu Asp Ala Gly 85 90 95 Leu Tyr Thr Gly Glu Val Thr Glu Ile Val Gly Gly Pro Gly Ser Gly 100 105 110 Lys Thr Gln Val Cys Leu Cys Met Ala Ala Asn Val Ala His Gly Leu 115 120 125 Gln Gln Asn Val Leu Tyr Val Asp Ser Asn Gly Gly Leu Thr Ala Ser 130 135 140 Arg Leu Leu Gln Leu Leu Gln Ala Lys Thr Gln Asp Glu Glu Glu Gln 145 150 155 160 Ala Glu Ala Leu Arg Arg Ile Gln Val Val His Ala Phe Asp Ile Phe 165 170 175 Gln Met Leu Asp Val Leu Gln Glu Leu Arg Gly Thr Val Ala Gln Gln 180 185 190 Val Thr Gly Ser Ser Gly Thr Val Lys Val Val Val Val Asp Ser Val 195 200 205 Thr Ala Val Val Ser Pro Leu Leu Gly Gly Gln Gln Arg Glu Gly Leu 210 215 220 Ala Leu Met Met Gln Leu Ala Arg Glu Leu Lys Thr Leu Ala Arg Asp 225 230 235 240 Leu Gly Met Ala Val Val Val Thr Asn His Ile Thr Arg Asp Arg Asp 245 250 255 Ser Gly Arg Leu Lys Pro Ala Leu Gly Arg Ser Trp Ser Phe Val Pro 260 265 270 Ser Thr Arg Ile Leu Leu Asp Thr Ile Glu Gly Ala Gly Ala Ser Gly 275 280 285 Gly Arg Arg Met Ala Cys Leu Ala Lys Ser Ser Arg Gln Pro Thr Gly 290 295 300 Phe Gln Glu Met Val Asp Ile Gly Thr Trp Gly Thr Ser Glu Gln Ser 305 310 315 320 Ala Thr Leu Gln Gly Asp Gln Thr 325 <210> 714 <211> 280 <212> PRT <213> Homo sapiens <400> 714 Met Cys Ser Ala Phe His Arg Ala Glu Ser Gly Thr Glu Leu Leu Ala 1 5 10 15 Arg Leu Glu Gly Arg Ser Ser Leu Lys Glu Ile Glu Pro Asn Leu Phe 20 25 30 Ala Asp Glu Asp Ser Pro Val His Gly Asp Ile Leu Glu Phe His Gly 35 40 45 Pro Glu Gly Thr Gly Lys Thr Glu Met Leu Tyr His Leu Thr Ala Arg 50 55 60 Cys Ile Leu Pro Lys Ser Glu Gly Gly Leu Glu Val Glu Val Leu Phe 65 70 75 80 Ile Asp Thr Asp Tyr His Phe Asp Met Leu Arg Leu Val Thr Ile Leu 85 90 95 Glu His Arg Leu Ser Gln Ser Ser Glu Glu Ile Ile Lys Tyr Cys Leu 100 105 110 Gly Arg Phe Phe Leu Val Tyr Cys Ser Ser Ser Thr His Leu Leu Leu 115 120 125 Thr Leu Tyr Ser Leu Glu Ser Met Phe Cys Ser His Pro Ser Leu Cys 130 135 140 Leu Leu Ile Leu Asp Ser Leu Ser Ala Phe Tyr Trp Ile Asp Arg Val 145 150 155 160 Asn Gly Gly Glu Ser Val Asn Leu Gln Glu Ser Thr Leu Arg Lys Cys 165 170 175 Ser Gln Cys Leu Glu Lys Leu Val Asn Asp Tyr Arg Leu Val Leu Phe 180 185 190 Ala Thr Thr Gln Thr Ile Met Gln Lys Ala Ser Ser Ser Ser Glu Glu 195 200 205 Pro Ser His Ala Ser Arg Arg Leu Cys Asp Val Asp Ile Asp Tyr Arg 210 215 220 Pro Tyr Leu Cys Lys Ala Trp Gln Gln Leu Val Lys His Arg Met Phe 225 230 235 240 Phe Ser Lys Gln Asp Asp Ser Gln Ser Ser Asn Gln Phe Ser Leu Val 245 250 255 Ser Arg Cys Leu Lys Ser Asn Ser Leu Lys Lys His Phe Phe Ile Ile 260 265 270 Gly Glu Ser Gly Val Glu Phe Cys 275 280 <210> 715 <211> 747 <212> PRT <213> Homo sapiens <400> 715 Met Arg Arg Ser Leu Ala Pro Ser Gln Leu Ala Lys Arg Lys Pro Glu 1 5 10 15 Gly Arg Ser Cys Asp Asp Glu Asp Trp Gln Pro Gly Leu Val Thr Pro 20 25 30 Arg Lys Arg Lys Ser Ser Ser Glu Thr Gln Ile Gln Glu Cys Phe Leu 35 40 45 Ser Pro Phe Arg Lys Pro Leu Ser Gln Leu Thr Asn Gln Pro Pro Cys 50 55 60 Leu Asp Ser Ser Gln His Glu Ala Phe Ile Arg Ser Ile Leu Ser Lys 65 70 75 80 Pro Phe Lys Val Pro Ile Pro Asn Tyr Gln Gly Pro Leu Gly Ser Arg 85 90 95 Ala Leu Gly Leu Lys Arg Ala Gly Val Arg Arg Ala Leu His Asp Pro 100 105 110 Leu Glu Lys Asp Ala Leu Val Leu Tyr Glu Pro Pro Pro Leu Ser Ala 115 120 125 His Asp Gln Leu Lys Leu Asp Lys Glu Lys Leu Pro Val His Val Val 130 135 140 Val Asp Pro Ile Leu Ser Lys Val Leu Arg Pro His Gln Arg Glu Gly 145 150 155 160 Val Lys Phe Leu Trp Glu Cys Val Thr Ser Arg Arg Ile Pro Gly Ser 165 170 175 His Gly Cys Ile Met Ala Asp Glu Met Gly Leu Gly Lys Thr Leu Gln 180 185 190 Cys Ile Thr Leu Met Trp Thr Leu Leu Arg Gln Ser Pro Glu Cys Lys 195 200 205 Pro Glu Ile Asp Lys Ala Val Val Val Ser Pro Ser Ser Leu Val Lys 210 215 220 Asn Trp Tyr Asn Glu Val Gly Lys Trp Leu Gly Gly Arg Ile Gln Pro 225 230 235 240 Leu Ala Ile Asp Gly Gly Ser Lys Asp Glu Ile Asp Gln Lys Leu Glu 245 250 255 Gly Phe Met Asn Gln Arg Gly Ala Arg Val Ser Ser Pro Ile Leu Ile 260 265 270 Ile Ser Tyr Glu Thr Phe Arg Leu His Val Gly Val Leu Gln Lys Gly 275 280 285 Ser Val Gly Leu Val Ile Cys Asp Glu Gly His Arg Leu Lys Asn Ser 290 295 300 Glu Asn Gln Thr Tyr Gln Ala Leu Asp Ser Leu Asn Thr Ser Arg Arg 305 310 315 320 Val Leu Ile Ser Gly Thr Pro Ile Gln Asn Asp Leu Leu Glu Tyr Phe 325 330 335 Ser Leu Val His Phe Val Asn Ser Gly Ile Leu Gly Thr Ala His Glu 340 345 350 Phe Lys Lys His Phe Glu Leu Pro Ile Leu Lys Gly Arg Asp Ala Ala 355 360 365 Ala Ser Glu Ala Asp Arg Gln Leu Gly Glu Glu Arg Leu Arg Glu Leu 370 375 380 Thr Ser Ile Val Asn Arg Cys Leu Ile Arg Arg Thr Ser Asp Ile Leu 385 390 395 400 Ser Lys Tyr Leu Pro Val Lys Ile Glu Gln Val Val Cys Cys Arg Leu 405 410 415 Thr Pro Leu Gln Thr Glu Leu Tyr Lys Arg Phe Leu Arg Gln Ala Lys 420 425 430 Pro Ala Glu Glu Leu Leu Glu Gly Lys Met Ser Val Ser Ser Leu Ser 435 440 445 Ser Ile Thr Ser Leu Lys Lys Leu Cys Asn His Pro Ala Leu Ile Tyr 450 455 460 Asp Lys Cys Val Glu Glu Glu Asp Gly Phe Val Gly Ala Leu Asp Leu 465 470 475 480 Phe Pro Pro Gly Tyr Ser Ser Lys Ala Leu Glu Pro Gln Leu Ser Gly 485 490 495 Lys Met Leu Val Leu Asp Tyr Ile Leu Ala Val Thr Arg Ser Arg Ser 500 505 510 Ser Asp Lys Val Val Leu Val Ser Asn Tyr Thr Gln Thr Leu Asp Leu 515 520 525 Phe Glu Lys Leu Cys Arg Ala Arg Arg Tyr Leu Tyr Val Arg Leu Asp 530 535 540 Gly Thr Met Ser Ile Lys Lys Arg Ala Lys Val Val Glu Arg Phe Asn 545 550 555 560 Ser Pro Ser Ser Pro Asp Phe Val Phe Met Leu Ser Ser Lys Ala Gly 565 570 575 Gly Cys Gly Leu Asn Leu Ile Gly Ala Asn Arg Leu Val Met Phe Asp 580 585 590 Pro Asp Trp Asn Pro Ala Asn Asp Glu Gln Ala Met Ala Arg Val Trp 595 600 605 Arg Asp Gly Gln Lys Lys Thr Cys Tyr Ile Tyr Arg Leu Leu Ser Ala 610 615 620 Gly Thr Ile Glu Glu Lys Ile Phe Gln Arg Gln Ser His Lys Lys Ala 625 630 635 640 Leu Ser Ser Cys Val Val Asp Glu Glu Gln Asp Val Glu Arg His Phe 645 650 655 Ser Leu Gly Glu Leu Lys Glu Leu Phe Ile Leu Asp Glu Ala Ser Leu 660 665 670 Ser Asp Thr His Asp Arg Leu His Cys Arg Arg Cys Val Asn Ser Arg 675 680 685 Gln Ile Arg Pro Pro Pro Asp Gly Ser Asp Cys Thr Ser Asp Leu Ala 690 695 700 Gly Trp Asn His Cys Thr Asp Lys Trp Gly Leu Arg Asp Glu Val Leu 705 710 715 720 Gln Ala Ala Trp Asp Ala Ala Ser Thr Ala Ile Thr Phe Val Phe His 725 730 735 Gln His Ser His Glu Glu Gln Arg Gly Leu Arg 740 745 <210> 716 <211> 1863 <212> PRT <213> Homo sapiens <400> 716 Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 1 5 10 15 Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 20 25 30 Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 35 40 45 Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 50 55 60 Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 65 70 75 80 Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 85 90 95 Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 100 105 110 Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 115 120 125 Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 130 135 140 Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 145 150 155 160 Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 165 170 175 Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn 180 185 190 Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr 195 200 205 Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 210 215 220 Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln 225 230 235 240 Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg 245 250 255 His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val Glu 260 265 270 Pro Cys Gly Thr Asn Thr His Ala Ser Ser Leu Gln His Glu Asn Ser 275 280 285 Ser Leu Leu Leu Thr Lys Asp Arg Met Asn Val Glu Lys Ala Glu Phe 290 295 300 Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn Arg 305 310 315 320 Trp Ala Gly Ser Lys Glu Thr Cys Asn Asp Arg Arg Thr Pro Ser Thr 325 330 335 Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu 340 345 350 Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Thr Glu 355 360 365 Asp Val Pro Trp Ile Thr Leu Asn Ser Ser Ile Gln Lys Val Asn Glu 370 375 380 Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His Asp 385 390 395 400 Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val Leu 405 410 415 Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu 420 425 430 Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val His 435 440 445 Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys Thr 450 455 460 Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Thr Glu Asn 465 470 475 480 Leu Ile Ile Gly Ala Phe Val Thr Glu Pro Gln Ile Ile Gln Glu Arg 485 490 495 Pro Leu Thr Asn Lys Leu Lys Arg Lys Arg Arg Pro Thr Ser Gly Leu 500 505 510 His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys Thr 515 520 525 Pro Glu Met Ile Asn Gln Gly Thr Asn Gln Thr Glu Gln Asn Gly Gln 530 535 540 Val Met Asn Ile Thr Asn Ser Gly His Glu Asn Lys Thr Lys Gly Asp 545 550 555 560 Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu Lys 565 570 575 Glu Ser Ala Phe Lys Thr Lys Ala Glu Pro Ile Ser Ser Ser Ile Ser 580 585 590 Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys Lys 595 600 605 Asn Arg Leu Arg Arg Lys Ser Ser Thr Arg His Ile His Ala Leu Glu 610 615 620 Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Thr Glu Leu Gln 625 630 635 640 Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr Asn 645 650 655 Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly Lys 660 665 670 Glu Pro Ala Thr Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln Thr 675 680 685 Ser Lys Arg His Asp Ser Asp Thr Phe Pro Glu Leu Lys Leu Thr Asn 690 695 700 Ala Pro Gly Ser Phe Thr Lys Cys Ser Asn Thr Ser Glu Leu Lys Glu 705 710 715 720 Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu Glu 725 730 735 Thr Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met Leu 740 745 750 Ser Gly Glu Arg Val Leu Gln Thr Glu Arg Ser Val Glu Ser Ser Ser 755 760 765 Ile Ser Leu Val Pro Gly Thr Asp Tyr Gly Thr Gln Glu Ser Ile Ser 770 775 780 Leu Leu Glu Val Ser Thr Leu Gly Lys Ala Lys Thr Glu Pro Asn Lys 785 790 795 800 Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile His 805 810 815 Gly Cys Ser Lys Asp Asn Arg Asn Asp Thr Glu Gly Phe Lys Tyr Pro 820 825 830 Leu Gly His Glu Val Asn His Ser Arg Glu Thr Ser Ile Glu Met Glu 835 840 845 Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Thr Phe Lys Val Ser 850 855 860 Lys Arg Gln Ser Phe Ala Pro Phe Ser Asn Pro Gly Asn Ala Glu Glu 865 870 875 880 Glu Cys Ala Thr Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln Ser 885 890 895 Pro Lys Val Thr Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly Lys 900 905 910 Asn Glu Ser Asn Ile Lys Pro Val Gln Thr Val Asn Ile Thr Ala Gly 915 920 925 Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys Cys 930 935 940 Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg Gly 945 950 955 960 Asn Glu Thr Gly Leu Ile Thr Pro Asn Lys His Gly Leu Leu Gln Asn 965 970 975 Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys Thr 980 985 990 Lys Cys Lys Lys Asn Leu Leu Glu Glu Asn Phe Glu Glu His Ser Met 995 1000 1005 Ser Pro Glu Arg Glu Met Gly Asn Glu Asn Ile Pro Ser Thr Val 1010 1015 1020 Ser Thr Ile Ser Arg Asn Asn Ile Arg Glu Asn Val Phe Lys Glu 1025 1030 1035 Ala Ser Ser Ser Asn Ile Asn Glu Val Gly Ser Ser Thr Asn Glu 1040 1045 1050 Val Gly Ser Ser Ile Asn Glu Ile Gly Ser Ser Asp Glu Asn Ile 1055 1060 1065 Gln Ala Glu Leu Gly Arg Asn Arg Gly Pro Lys Leu Asn Ala Met 1070 1075 1080 Leu Arg Leu Gly Val Leu Gln Pro Glu Val Tyr Lys Gln Ser Leu 1085 1090 1095 Pro Gly Ser Asn Cys Lys His Pro Glu Ile Lys Lys Gln Glu Tyr 1100 1105 1110 Glu Glu Val Val Gln Thr Val Asn Thr Asp Phe Ser Pro Tyr Leu 1115 1120 1125 Ile Ser Asp Asn Leu Glu Gln Pro Met Gly Ser Ser His Ala Ser 1130 1135 1140 Gln Val Cys Ser Glu Thr Pro Asp Asp Leu Leu Asp Asp Gly Glu 1145 1150 1155 Ile Lys Glu Asp Thr Ser Phe Ala Glu Asn Asp Ile Lys Glu Ser 1160 1165 1170 Ser Ala Val Phe Ser Lys Ser Val Gln Lys Gly Glu Leu Ser Arg 1175 1180 1185 Ser Pro Ser Pro Phe Thr His Thr His Leu Ala Gln Gly Tyr Arg 1190 1195 1200 Arg Gly Ala Lys Lys Leu Glu Ser Ser Glu Glu Asn Leu Ser Ser 1205 1210 1215 Glu Asp Glu Glu Leu Pro Cys Phe Gln His Leu Leu Phe Gly Lys 1220 1225 1230 Val Asn Asn Ile Pro Ser Gln Ser Thr Arg His Ser Thr Val Ala 1235 1240 1245 Thr Glu Cys Leu Ser Lys Asn Thr Glu Glu Asn Leu Leu Ser Leu 1250 1255 1260 Lys Asn Ser Leu Asn Asp Cys Ser Asn Gln Val Ile Leu Ala Lys 1265 1270 1275 Ala Ser Gln Glu His His Leu Ser Glu Glu Thr Lys Cys Ser Ala 1280 1285 1290 Ser Leu Phe Ser Ser Gln Cys Ser Glu Leu Glu Asp Leu Thr Ala 1295 1300 1305 Asn Thr Asn Thr Gln Asp Pro Phe Leu Ile Gly Ser Ser Lys Gln 1310 1315 1320 Met Arg His Gln Ser Glu Ser Gln Gly Val Gly Leu Ser Asp Lys 1325 1330 1335 Glu Leu Val Ser Asp Asp Glu Glu Arg Gly Thr Gly Leu Glu Glu 1340 1345 1350 Asn Asn Gln Glu Glu Gln Ser Met Asp Ser Asn Leu Gly Glu Ala 1355 1360 1365 Ala Ser Gly Cys Glu Ser Glu Thr Ser Val Ser Glu Asp Cys Ser 1370 1375 1380 Gly Leu Ser Ser Gln Ser Asp Ile Leu Thr Thr Gln Gln Arg Asp 1385 1390 1395 Thr Met Gln His Asn Leu Ile Lys Leu Gln Gln Glu Met Ala Glu 1400 1405 1410 Leu Glu Ala Val Leu Glu Gln His Gly Ser Gln Pro Ser Asn Ser 1415 1420 1425 Tyr Pro Ser Ile Ile Ser Asp Ser Ser Ala Leu Glu Asp Leu Arg 1430 1435 1440 Asn Pro Glu Gln Ser Thr Ser Glu Lys Ala Val Leu Thr Ser Gln 1445 1450 1455 Lys Ser Ser Glu Tyr Pro Ile Ser Gln Asn Pro Glu Gly Leu Ser 1460 1465 1470 Ala Asp Lys Phe Glu Val Ser Ala Asp Ser Ser Thr Ser Lys Asn 1475 1480 1485 Lys Glu Pro Gly Val Glu Arg Ser Ser Pro Ser Lys Cys Pro Ser 1490 1495 1500 Leu Asp Asp Arg Trp Tyr Met His Ser Cys Ser Gly Ser Leu Gln 1505 1510 1515 Asn Arg Asn Tyr Pro Ser Gln Glu Glu Leu Ile Lys Val Val Asp 1520 1525 1530 Val Glu Glu Gln Gln Leu Glu Glu Ser Gly Pro His Asp Leu Thr 1535 1540 1545 Glu Thr Ser Tyr Leu Pro Arg Gln Asp Leu Glu Gly Thr Pro Tyr 1550 1555 1560 Leu Glu Ser Gly Ile Ser Leu Phe Ser Asp Asp Pro Glu Ser Asp 1565 1570 1575 Pro Ser Glu Asp Arg Ala Pro Glu Ser Ala Arg Val Gly Asn Ile 1580 1585 1590 Pro Ser Ser Thr Ser Ala Leu Lys Val Pro Gln Leu Lys Val Ala 1595 1600 1605 Glu Ser Ala Gln Ser Pro Ala Ala Ala His Thr Thr Asp Thr Ala 1610 1615 1620 Gly Tyr Asn Ala Met Glu Glu Ser Val Ser Arg Glu Lys Pro Glu 1625 1630 1635 Leu Thr Ala Ser Thr Glu Arg Val Asn Lys Arg Met Ser Met Val 1640 1645 1650 Val Ser Gly Leu Thr Pro Glu Glu Phe Met Leu Val Tyr Lys Phe 1655 1660 1665 Ala Arg Lys His His Ile Thr Leu Thr Asn Leu Ile Thr Glu Glu 1670 1675 1680 Thr Thr His Val Val Met Lys Thr Asp Ala Glu Phe Val Cys Glu 1685 1690 1695 Arg Thr Leu Lys Tyr Phe Leu Gly Ile Ala Gly Gly Lys Trp Val 1700 1705 1710 Val Ser Tyr Phe Trp Val Thr Gln Ser Ile Lys Glu Arg Lys Met 1715 1720 1725 Leu Asn Glu His Asp Phe Glu Val Arg Gly Asp Val Val Asn Gly 1730 1735 1740 Arg Asn His Gln Gly Pro Lys Arg Ala Arg Glu Ser Gln Asp Arg 1745 1750 1755 Lys Ile Phe Arg Gly Leu Glu Ile Cys Cys Tyr Gly Pro Phe Thr 1760 1765 1770 Asn Met Pro Thr Asp Gln Leu Glu Trp Met Val Gln Leu Cys Gly 1775 1780 1785 Ala Ser Val Val Lys Glu Leu Ser Ser Phe Thr Leu Gly Thr Gly 1790 1795 1800 Val His Pro Ile Val Val Val Gln Pro Asp Ala Trp Thr Glu Asp 1805 1810 1815 Asn Gly Phe His Ala Ile Gly Gln Met Cys Glu Ala Pro Val Val 1820 1825 1830 Thr Arg Glu Trp Val Leu Asp Ser Val Ala Leu Tyr Gln Cys Gln 1835 1840 1845 Glu Leu Asp Thr Tyr Leu Ile Pro Gln Ile Pro His Ser His Tyr 1850 1855 1860 <210> 717 <211> 732 <212> PRT <213> Homo sapiens <400> 717 Met Val Arg Ser Gly Asn Lys Ala Ala Val Val Leu Cys Met Asp Val 1 5 10 15 Gly Phe Thr Met Ser Asn Ser Ile Pro Gly Ile Glu Ser Pro Phe Glu 20 25 30 Gln Ala Lys Lys Val Ile Thr Met Phe Val Gln Arg Gln Val Phe Ala 35 40 45 Glu Asn Lys Asp Glu Ile Ala Leu Val Leu Phe Gly Thr Asp Gly Thr 50 55 60 Asp Asn Pro Leu Ser Gly Gly Asp Gln Tyr Gln Asn Ile Thr Val His 65 70 75 80 Arg His Leu Met Leu Pro Asp Phe Asp Leu Leu Glu Asp Ile Glu Ser 85 90 95 Lys Ile Gln Pro Gly Ser Gln Gln Ala Asp Phe Leu Asp Ala Leu Ile 100 105 110 Val Ser Met Asp Val Ile Gln His Glu Thr Ile Gly Lys Lys Phe Glu 115 120 125 Lys Arg His Ile Glu Ile Phe Thr Asp Leu Ser Ser Arg Phe Ser Lys 130 135 140 Ser Gln Leu Asp Ile Ile Ile His Ser Leu Lys Lys Cys Asp Ile Ser 145 150 155 160 Leu Gln Phe Phe Leu Pro Phe Ser Leu Gly Lys Glu Asp Gly Ser Gly 165 170 175 Asp Arg Gly Asp Gly Pro Phe Arg Leu Gly Gly His Gly Pro Ser Phe 180 185 190 Pro Leu Lys Gly Ile Thr Glu Gln Gln Lys Glu Gly Leu Glu Ile Val 195 200 205 Lys Met Val Met Ile Ser Leu Glu Gly Glu Asp Gly Leu Asp Glu Ile 210 215 220 Tyr Ser Phe Ser Glu Ser Leu Arg Lys Leu Cys Val Phe Lys Lys Ile 225 230 235 240 Glu Arg His Ser Ile His Trp Pro Cys Arg Leu Thr Ile Gly Ser Asn 245 250 255 Leu Ser Ile Arg Ile Ala Ala Tyr Lys Ser Ile Leu Gln Glu Arg Val 260 265 270 Lys Lys Thr Trp Thr Val Val Asp Ala Lys Thr Leu Lys Lys Glu Asp 275 280 285 Ile Gln Lys Glu Thr Val Tyr Cys Leu Asn Asp Asp Asp Glu Thr Glu 290 295 300 Val Leu Lys Glu Asp Ile Ile Gln Gly Phe Arg Tyr Gly Ser Asp Ile 305 310 315 320 Val Pro Phe Ser Lys Val Asp Glu Glu Gln Met Lys Tyr Lys Ser Glu 325 330 335 Gly Lys Cys Phe Ser Val Leu Gly Phe Cys Lys Ser Ser Gln Val Gln 340 345 350 Arg Arg Phe Phe Met Gly Asn Gln Val Leu Lys Val Phe Ala Ala Arg 355 360 365 Asp Asp Glu Ala Ala Ala Val Ala Leu Ser Ser Leu Ile His Ala Leu 370 375 380 Asp Asp Leu Asp Met Val Ala Ile Val Arg Tyr Ala Tyr Asp Lys Arg 385 390 395 400 Ala Asn Pro Gln Val Gly Val Ala Phe Pro His Ile Lys His Asn Tyr 405 410 415 Glu Cys Leu Val Tyr Val Gln Leu Pro Phe Met Glu Asp Leu Arg Gln 420 425 430 Tyr Met Phe Ser Ser Leu Lys Asn Ser Lys Lys Tyr Ala Pro Thr Glu 435 440 445 Ala Gln Leu Asn Ala Val Asp Ala Leu Ile Asp Ser Met Ser Leu Ala 450 455 460 Lys Lys Asp Glu Lys Thr Asp Thr Leu Glu Asp Leu Phe Pro Thr Thr 465 470 475 480 Lys Ile Pro Asn Pro Arg Phe Gln Arg Leu Phe Gln Cys Leu Leu His 485 490 495 Arg Ala Leu His Pro Arg Glu Pro Leu Pro Pro Ile Gln Gln His Ile 500 505 510 Trp Asn Met Leu Asn Pro Pro Ala Glu Val Thr Thr Lys Ser Gln Ile 515 520 525 Pro Leu Ser Lys Ile Lys Thr Leu Phe Pro Leu Ile Glu Ala Lys Lys 530 535 540 Lys Asp Gln Val Thr Ala Gln Glu Ile Phe Gln Asp Asn His Glu Asp 545 550 555 560 Gly Pro Thr Ala Lys Lys Leu Lys Thr Glu Gln Gly Gly Ala His Phe 565 570 575 Ser Val Ser Ser Leu Ala Glu Gly Ser Val Thr Ser Val Gly Ser Val 580 585 590 Asn Pro Ala Glu Asn Phe Arg Val Leu Val Lys Gln Lys Lys Ala Ser 595 600 605 Phe Glu Glu Ala Ser Asn Gln Leu Ile Asn His Ile Glu Gln Phe Leu 610 615 620 Asp Thr Asn Glu Thr Pro Tyr Phe Met Lys Ser Ile Asp Cys Ile Arg 625 630 635 640 Ala Phe Arg Glu Glu Ala Ile Lys Phe Ser Glu Glu Gln Arg Phe Asn 645 650 655 Asn Phe Leu Lys Ala Leu Gln Glu Lys Val Glu Ile Lys Gln Leu Asn 660 665 670 His Phe Trp Glu Ile Val Val Gln Asp Gly Ile Thr Leu Ile Thr Lys 675 680 685 Glu Glu Ala Ser Gly Ser Ser Val Thr Ala Glu Glu Ala Lys Lys Phe 690 695 700 Leu Ala Pro Lys Asp Lys Pro Ser Gly Asp Thr Ala Ala Val Phe Glu 705 710 715 720 Glu Gly Gly Asp Val Asp Asp Leu Leu Asp Met Ile 725 730 <210> 718 <211> 334 <212> PRT <213> Homo sapiens <400> 718 Met Glu Arg Lys Ile Ser Arg Ile His Leu Val Ser Glu Pro Ser Ile 1 5 10 15 Thr His Phe Leu Gln Val Ser Trp Glu Lys Thr Leu Glu Ser Gly Phe 20 25 30 Val Ile Thr Leu Thr Asp Gly His Ser Ala Trp Thr Gly Thr Val Ser 35 40 45 Glu Ser Glu Ile Ser Gln Glu Ala Asp Asp Met Ala Met Glu Lys Gly 50 55 60 Lys Tyr Val Gly Glu Leu Arg Lys Ala Leu Leu Ser Gly Ala Gly Pro 65 70 75 80 Ala Asp Val Tyr Thr Phe Asn Phe Ser Lys Glu Ser Cys Tyr Phe Phe 85 90 95 Phe Glu Lys Asn Leu Lys Asp Val Ser Phe Arg Leu Gly Ser Phe Asn 100 105 110 Leu Glu Lys Val Glu Asn Pro Ala Glu Val Ile Arg Glu Leu Ile Cys 115 120 125 Tyr Cys Leu Asp Thr Ile Ala Glu Asn Gln Ala Lys Asn Glu His Leu 130 135 140 Gln Lys Glu Asn Glu Arg Leu Leu Arg Asp Trp Asn Asp Val Gln Gly 145 150 155 160 Arg Phe Glu Lys Cys Val Ser Ala Lys Glu Ala Leu Glu Thr Asp Leu 165 170 175 Tyr Lys Arg Phe Ile Leu Val Leu Asn Glu Lys Lys Thr Lys Ile Arg 180 185 190 Ser Leu His Asn Lys Leu Leu Asn Ala Ala Gln Glu Arg Glu Lys Asp 195 200 205 Ile Lys Gln Glu Gly Glu Thr Ala Ile Cys Ser Glu Met Thr Ala Asp 210 215 220 Arg Asp Pro Val Tyr Asp Glu Ser Thr Asp Glu Glu Ser Glu Asn Gln 225 230 235 240 Thr Asp Leu Ser Gly Leu Ala Ser Ala Ala Val Ser Lys Asp Asp Ser 245 250 255 Ile Ile Ser Ser Leu Asp Val Thr Asp Ile Ala Pro Ser Arg Lys Arg 260 265 270 Arg Gln Arg Met Gln Arg Asn Leu Gly Thr Glu Pro Lys Met Ala Pro 275 280 285 Gln Glu Asn Gln Leu Gln Glu Lys Glu Lys Pro Asp Ser Ser Leu Pro 290 295 300 Glu Thr Ser Lys Lys Glu His Ile Ser Ala Glu Asn Met Ser Leu Glu 305 310 315 320 Thr Leu Arg Asn Ser Ser Pro Glu Asp Leu Phe Asp Glu Ile 325 330 <210> 719 <211> 354 <212> PRT <213> Homo sapiens <400> 719 Met Ala Thr Pro Leu Val Ala Gly Pro Ala Ala Leu Arg Phe Ala Ala 1 5 10 15 Ala Ala Ser Trp Gln Val Val Arg Gly Arg Cys Val Glu His Phe Pro 20 25 30 Arg Val Leu Glu Phe Leu Arg Ser Leu Arg Ala Val Ala Pro Gly Leu 35 40 45 Val Arg Tyr Arg His His Glu Arg Leu Cys Met Gly Leu Lys Ala Lys 50 55 60 Val Val Val Glu Leu Ile Leu Gln Gly Arg Pro Trp Ala Gln Val Leu 65 70 75 80 Lys Ala Leu Asn His His Phe Pro Glu Ser Gly Pro Ile Val Arg Asp 85 90 95 Pro Lys Ala Thr Lys Gln Asp Leu Arg Lys Ile Leu Glu Ala Gln Glu 100 105 110 Thr Phe Tyr Gln Gln Val Lys Gln Leu Ser Glu Ala Pro Val Asp Leu 115 120 125 Ala Ser Lys Leu Gln Glu Leu Glu Gln Glu Tyr Gly Glu Pro Phe Leu 130 135 140 Ala Ala Met Glu Lys Leu Leu Phe Glu Tyr Leu Cys Gln Leu Glu Lys 145 150 155 160 Ala Leu Pro Thr Pro Gln Ala Gln Gln Leu Gln Asp Val Leu Ser Trp 165 170 175 Met Gln Pro Gly Val Ser Ile Thr Ser Ser Leu Ala Trp Arg Gln Tyr 180 185 190 Gly Val Asp Met Gly Trp Leu Leu Pro Glu Cys Ser Val Thr Asp Ser 195 200 205 Val Asn Leu Ala Glu Pro Met Glu Gln Asn Pro Pro Gln Gln Gln Arg 210 215 220 Leu Ala Leu His Asn Pro Leu Pro Lys Ala Lys Pro Gly Thr His Leu 225 230 235 240 Pro Gln Gly Pro Ser Ser Arg Thr His Pro Glu Pro Leu Ala Gly Arg 245 250 255 His Phe Asn Leu Ala Pro Leu Gly Arg Arg Arg Val Gln Ser Gln Trp 260 265 270 Ala Ser Thr Arg Gly Gly His Lys Glu Arg Pro Thr Val Met Leu Phe 275 280 285 Pro Phe Arg Asn Leu Gly Ser Pro Thr Gln Val Ile Ser Asn Pro Glu 290 295 300 Ser Lys Glu Glu His Ala Ile Tyr Thr Ala Asp Leu Ala Met Gly Thr 305 310 315 320 Arg Ala Pro Ser Asn Gly Lys Tyr Lys Gly Pro Tyr Gln Thr Leu Gly 325 330 335 Gly Arg Ala Leu Lys Glu Asn Pro Val Asp Leu Pro Ala Thr Glu Gln 340 345 350 Lys Glu <210> 720 <211> 389 <212> PRT <213> Homo sapiens <400> 720 Met Ala Glu Pro Asp Pro Ser His Pro Leu Glu Thr Gln Ala Gly Lys 1 5 10 15 Val Gln Glu Ala Gln Asp Ser Asp Ser Asp Ser Glu Gly Gly Ala Ala 20 25 30 Gly Gly Glu Ala Asp Met Asp Phe Leu Arg Asn Leu Phe Ser Gln Thr 35 40 45 Leu Ser Leu Gly Ser Gln Lys Glu Arg Leu Leu Asp Glu Leu Thr Leu 50 55 60 Glu Gly Val Ala Arg Tyr Met Gln Ser Glu Arg Cys Arg Arg Val Ile 65 70 75 80 Cys Leu Val Gly Ala Gly Ile Ser Thr Ser Ala Gly Ile Pro Asp Phe 85 90 95 Arg Ser Pro Ser Thr Gly Leu Tyr Asp Asn Leu Glu Lys Tyr His Leu 100 105 110 Pro Tyr Pro Glu Ala Ile Phe Glu Ile Ser Tyr Phe Lys Lys His Pro 115 120 125 Glu Pro Phe Phe Ala Leu Ala Lys Glu Leu Tyr Pro Gly Gln Phe Lys 130 135 140 Pro Thr Ile Cys His Tyr Phe Met Arg Leu Leu Lys Asp Lys Gly Leu 145 150 155 160 Leu Leu Arg Cys Tyr Thr Gln Asn Ile Asp Thr Leu Glu Arg Ile Ala 165 170 175 Gly Leu Glu Gln Glu Asp Leu Val Glu Ala His Gly Thr Phe Tyr Thr 180 185 190 Ser His Cys Val Ser Ala Ser Cys Arg His Glu Tyr Pro Leu Ser Trp 195 200 205 Met Lys Glu Lys Ile Phe Ser Glu Val Thr Pro Lys Cys Glu Asp Cys 210 215 220 Gln Ser Leu Val Lys Pro Asp Ile Val Phe Phe Gly Glu Ser Leu Pro 225 230 235 240 Ala Arg Phe Phe Ser Cys Met Gln Ser Asp Phe Leu Lys Val Asp Leu 245 250 255 Leu Leu Val Met Gly Thr Ser Leu Gln Val Gln Pro Phe Ala Ser Leu 260 265 270 Ile Ser Lys Ala Pro Leu Ser Thr Pro Arg Leu Leu Ile Asn Lys Glu 275 280 285 Lys Ala Gly Gln Ser Asp Pro Phe Leu Gly Met Ile Met Gly Leu Gly 290 295 300 Gly Gly Met Asp Phe Asp Ser Lys Lys Ala Tyr Arg Asp Val Ala Trp 305 310 315 320 Leu Gly Glu Cys Asp Gln Gly Cys Leu Ala Leu Ala Glu Leu Leu Gly 325 330 335 Trp Lys Lys Glu Leu Glu Asp Leu Val Arg Arg Glu His Ala Ser Ile 340 345 350 Asp Ala Gln Ser Gly Ala Gly Val Pro Asn Pro Ser Thr Ser Ala Ser 355 360 365 Pro Lys Lys Ser Pro Pro Pro Ala Lys Asp Glu Ala Arg Thr Thr Glu 370 375 380 Arg Glu Lys Pro Gln 385 <210> 721 <211> 207 <212> PRT <213> Homo sapiens <400> 721 Met Asp Lys Asp Cys Glu Met Lys Arg Thr Thr Leu Asp Ser Pro Leu 1 5 10 15 Gly Lys Leu Glu Leu Ser Gly Cys Glu Gln Gly Leu His Glu Ile Lys 20 25 30 Leu Leu Gly Lys Gly Thr Ser Ala Ala Asp Ala Val Glu Val Pro Ala 35 40 45 Pro Ala Ala Val Leu Gly Gly Pro Glu Pro Leu Met Gln Cys Thr Ala 50 55 60 Trp Leu Asn Ala Tyr Phe His Gln Pro Glu Ala Ile Glu Glu Phe Pro 65 70 75 80 Val Pro Ala Leu His His Pro Val Phe Gln Gln Glu Ser Phe Thr Arg 85 90 95 Gln Val Leu Trp Lys Leu Leu Lys Val Val Lys Phe Gly Glu Val Ile 100 105 110 Ser Tyr Gln Gln Leu Ala Ala Leu Ala Gly Asn Pro Lys Ala Ala Arg 115 120 125 Ala Val Gly Gly Ala Met Arg Gly Asn Pro Val Pro Ile Leu Ile Pro 130 135 140 Cys His Arg Val Val Cys Ser Ser Gly Ala Val Gly Asn Tyr Ser Gly 145 150 155 160 Gly Leu Ala Val Lys Glu Trp Leu Leu Ala His Glu Gly His Arg Leu 165 170 175 Gly Lys Pro Gly Leu Gly Gly Ser Ser Gly Leu Ala Gly Ala Trp Leu 180 185 190 Lys Gly Ala Gly Ala Thr Ser Gly Ser Pro Pro Ala Gly Arg Asn 195 200 205 <210> 722 <211> 164 <212> PRT <213> Homo sapiens <400> 722 Met Pro Cys Ser Glu Glu Thr Pro Ala Ile Ser Pro Ser Lys Arg Ala 1 5 10 15 Arg Pro Ala Glu Val Gly Gly Met Gln Leu Arg Phe Ala Arg Leu Ser 20 25 30 Glu His Ala Thr Ala Pro Thr Arg Gly Ser Ala Arg Ala Ala Gly Tyr 35 40 45 Asp Leu Tyr Ser Ala Tyr Asp Tyr Thr Ile Pro Pro Met Glu Lys Ala 50 55 60 Val Val Lys Thr Asp Ile Gln Ile Ala Leu Pro Ser Gly Cys Tyr Gly 65 70 75 80 Arg Val Ala Pro Arg Ser Gly Leu Ala Ala Lys His Phe Ile Asp Val 85 90 95 Gly Ala Gly Val Ile Asp Glu Asp Tyr Arg Gly Asn Val Gly Val Val 100 105 110 Leu Phe Asn Phe Gly Lys Glu Lys Phe Glu Val Lys Lys Gly Asp Arg 115 120 125 Ile Ala Gln Leu Ile Cys Glu Arg Ile Phe Tyr Pro Glu Ile Glu Glu 130 135 140 Val Gln Ala Leu Asp Asp Thr Glu Arg Gly Ser Gly Gly Phe Gly Ser 145 150 155 160 Thr Gly Lys Asn <210> 723 <211> 1208 <212> PRT <213> Homo sapiens <400> 723 Met Asp Leu His Met Met Asn Cys Glu Leu Leu Ala Thr Cys Ser Ala 1 5 10 15 Leu Gly Tyr Leu Glu Gly Asp Thr Tyr His Lys Glu Pro Asp Cys Leu 20 25 30 Glu Ser Val Lys Asp Leu Ile Arg Tyr Leu Arg His Glu Asp Glu Thr 35 40 45 Arg Asp Val Arg Gln Gln Leu Gly Ala Ala Gln Ile Leu Gln Ser Asp 50 55 60 Leu Leu Pro Ile Leu Thr Gln His His Gln Asp Lys Pro Leu Phe Asp 65 70 75 80 Ala Val Ile Arg Leu Met Val Asn Leu Thr Gln Pro Ala Leu Leu Cys 85 90 95 Phe Gly Asn Leu Pro Lys Glu Pro Ser Phe Arg His His Phe Leu Gln 100 105 110 Val Leu Thr Tyr Leu Gln Ala Tyr Lys Glu Ala Phe Ala Ser Glu Lys 115 120 125 Ala Phe Gly Val Leu Ser Glu Thr Leu Tyr Glu Leu Leu Gln Leu Gly 130 135 140 Trp Glu Glu Arg Gln Glu Glu Asp Asn Leu Leu Ile Glu Arg Ile Leu 145 150 155 160 Leu Leu Val Arg Asn Ile Leu His Val Pro Ala Asp Leu Asp Gln Glu 165 170 175 Lys Lys Ile Asp Asp Asp Ala Ser Ala His Asp Gln Leu Leu Trp Ala 180 185 190 Ile His Leu Ser Gly Leu Asp Asp Leu Leu Leu Phe Leu Ala Ser Ser 195 200 205 Ser Ala Glu Glu Gln Trp Ser Leu His Val Leu Glu Ile Val Ser Leu 210 215 220 Met Phe Arg Asp Gln Asn Pro Glu Gln Leu Ala Gly Val Gly Gln Gly 225 230 235 240 Arg Leu Ala Gln Glu Arg Ser Ala Asp Phe Ala Glu Leu Glu Val Leu 245 250 255 Arg Gln Arg Glu Met Ala Glu Lys Lys Thr Arg Ala Leu Gln Arg Gly 260 265 270 Asn Arg His Ser Arg Phe Gly Gly Ser Tyr Ile Val Gln Gly Leu Lys 275 280 285 Ser Ile Gly Glu Arg Asp Leu Ile Phe His Lys Gly Leu His Asn Leu 290 295 300 Arg Asn Tyr Ser Ser Asp Leu Gly Lys Gln Pro Lys Lys Val Pro Lys 305 310 315 320 Arg Arg Gln Ala Ala Arg Glu Leu Ser Ile Gln Arg Arg Ser Ala Leu 325 330 335 Asn Val Arg Leu Phe Leu Arg Asp Phe Cys Ser Glu Phe Leu Glu Asn 340 345 350 Cys Tyr Asn Arg Leu Met Gly Ser Val Lys Asp His Leu Leu Arg Glu 355 360 365 Lys Ala Gln Gln His Asp Glu Thr Tyr Tyr Met Trp Ala Leu Ala Phe 370 375 380 Phe Met Ala Phe Asn Arg Ala Ala Ser Phe Arg Pro Gly Leu Val Ser 385 390 395 400 Glu Thr Leu Ser Val Arg Thr Phe His Phe Ile Glu Gln Asn Leu Thr 405 410 415 Asn Tyr Tyr Glu Met Met Leu Thr Asp Arg Lys Glu Ala Ala Ser Trp 420 425 430 Ala Arg Arg Met His Leu Ala Leu Lys Ala Tyr Gln Glu Leu Leu Ala 435 440 445 Thr Val Asn Glu Met Asp Leu Ser Pro Asp Glu Ala Val Arg Glu Ser 450 455 460 Ser Arg Ile Ile Lys Asn Asn Ile Phe Tyr Val Met Glu Tyr Arg Glu 465 470 475 480 Leu Phe Leu Ala Leu Phe Arg Lys Phe Asp Glu Arg Cys Gln Pro Arg 485 490 495 Ser Phe Leu Arg Asp Leu Val Glu Thr Thr His Leu Phe Leu Lys Met 500 505 510 Leu Glu Arg Phe Cys Arg Ser Arg Gly Asn Leu Val Val Gln Asn Lys 515 520 525 Gln Lys Lys Arg Arg Lys Lys Lys Lys Lys Val Leu Asp Gln Ala Ile 530 535 540 Val Ser Gly Asn Val Pro Ser Ser Pro Glu Glu Val Glu Ala Val Trp 545 550 555 560 Pro Ala Leu Ala Glu Gln Leu Gln Cys Cys Ala Gln Asn Ser Glu Leu 565 570 575 Ser Met Asp Ser Val Val Pro Phe Asp Ala Ala Ser Glu Val Pro Val 580 585 590 Glu Glu Gln Arg Ala Glu Ala Met Val Arg Ile Gln Asp Cys Leu Leu 595 600 605 Ala Gly Gln Ala Pro Gln Ala Leu Thr Leu Leu Arg Ser Ala Arg Glu 610 615 620 Val Trp Pro Glu Gly Asp Val Phe Gly Ser Gln Asp Ile Ser Pro Glu 625 630 635 640 Glu Glu Ile Gln Leu Leu Lys Gln Ile Leu Ser Ala Pro Leu Pro Arg 645 650 655 Gln Gln Gly Pro Glu Glu Arg Gly Ala Glu Glu Glu Glu Glu Glu Glu 660 665 670 Glu Glu Glu Glu Glu Glu Leu Gln Val Val Gln Val Ser Glu Lys Glu 675 680 685 Phe Asn Phe Leu Asp Tyr Leu Lys Arg Phe Ala Cys Ser Thr Val Val 690 695 700 Arg Ala Tyr Val Leu Leu Leu Arg Ser Tyr Gln Gln Asn Ser Ala His 705 710 715 720 Thr Asn His Cys Ile Val Lys Met Leu His Arg Leu Ala His Asp Leu 725 730 735 Lys Met Glu Ala Leu Leu Phe Gln Leu Ser Val Phe Cys Leu Phe Asn 740 745 750 Arg Leu Leu Ser Asp Pro Ala Ala Gly Ala Tyr Lys Glu Leu Val Thr 755 760 765 Phe Ala Lys Tyr Ile Leu Gly Lys Phe Phe Ala Leu Ala Ala Val Asn 770 775 780 Gln Lys Ala Phe Val Glu Leu Leu Phe Trp Lys Asn Thr Ala Val Val 785 790 795 800 Arg Glu Met Thr Glu Gly Tyr Gly Ser Leu Asp Asp Arg Ser Ser Ser 805 810 815 Arg Arg Ala Pro Thr Trp Ser Pro Glu Glu Glu Ala His Leu Gln Glu 820 825 830 Leu Tyr Leu Ala Asn Lys Asp Val Glu Gly Gln Asp Val Val Glu Ala 835 840 845 Ile Leu Ala His Leu Asn Thr Val Pro Arg Thr Arg Lys Gln Ile Ile 850 855 860 His His Leu Val Gln Met Gly Leu Ala Asp Ser Val Lys Asp Phe Gln 865 870 875 880 Arg Lys Gly Thr His Ile Val Leu Trp Thr Gly Asp Gln Glu Leu Glu 885 890 895 Leu Gln Arg Leu Phe Glu Glu Phe Arg Asp Ser Asp Asp Val Leu Gly 900 905 910 His Ile Met Lys Asn Ile Thr Ala Lys Arg Ser Arg Ala Arg Ile Val 915 920 925 Asp Lys Leu Leu Ala Leu Gly Leu Val Ala Glu Arg Arg Glu Leu Tyr 930 935 940 Lys Lys Arg Gln Lys Lys Leu Ala Ser Ser Ile Leu Pro Asn Gly Ala 945 950 955 960 Glu Ser Leu Lys Asp Phe Cys Gln Glu Asp Leu Glu Glu Glu Glu Asn 965 970 975 Leu Pro Glu Glu Asp Ser Glu Glu Glu Glu Glu Gly Gly Ser Glu Ala 980 985 990 Glu Gln Val Gln Gly Ser Leu Val Leu Ser Asn Glu Asn Leu Gly Gln 995 1000 1005 Ser Leu His Gln Glu Gly Phe Ser Ile Pro Leu Leu Trp Leu Gln 1010 1015 1020 Asn Cys Leu Ile Arg Ala Ala Asp Asp Arg Glu Glu Asp Gly Cys 1025 1030 1035 Ser Gln Ala Val Pro Leu Val Pro Leu Thr Glu Glu Asn Glu Glu 1040 1045 1050 Ala Met Glu Asn Glu Gln Phe Gln Gln Leu Leu Arg Lys Leu Gly 1055 1060 1065 Val Arg Pro Pro Ala Ser Gly Gln Glu Thr Phe Trp Arg Ile Pro 1070 1075 1080 Ala Lys Leu Ser Pro Thr Gln Leu Arg Arg Ala Ala Ala Ser Leu 1085 1090 1095 Ser Gln Pro Glu Glu Glu Gln Lys Leu Gln Pro Glu Leu Gln Pro 1100 1105 1110 Lys Val Pro Gly Glu Gln Gly Ser Asp Glu Glu His Cys Lys Glu 1115 1120 1125 His Arg Ala Gln Ala Leu Arg Ala Leu Leu Leu Ala His Lys Lys 1130 1135 1140 Lys Ala Gly Leu Ala Ser Pro Glu Glu Glu Asp Ala Val Gly Lys 1145 1150 1155 Glu Pro Leu Lys Ala Ala Pro Lys Lys Arg Gln Leu Leu Asp Ser 1160 1165 1170 Asp Glu Glu Gln Glu Glu Asp Glu Gly Arg Asn Arg Ala Pro Glu 1175 1180 1185 Leu Gly Ala Pro Gly Ile Gln Lys Lys Lys Arg Tyr Gln Ile Glu 1190 1195 1200 Asp Asp Glu Asp Asp 1205 <210> 724 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 724 ggaaaaucug gccacucuct t 21 <210> 725 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 725 gguuguucca ccgagauuct t 21 <210> 726 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 726 ggaugaacug augaccauat t 21 <210> 727 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 727 ggcaagaaag agaaugguct t 21 <210> 728 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 728 gcagcuggca cagaugacgt t 21 <210> 729 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 729 ggcgcuguau gaagcacuut t 21 <210> 730 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 730 gaugcaggau gacaaucagt t 21 <210> 731 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 731 caaaugcauu cuucagcuat t 21 <210> 732 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 732 ggaguuccug cggcaguact t 21 <210> 733 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 733 gaccguaaag agaucccuct t 21 <210> 734 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 734 gcucaugagg cguuacauat t 21 <210> 735 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 735 gucucaaaug cggaagaagt t 21 <210> 736 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 736 guaugccuug guagacuuut t 21 <210> 737 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 737 gaagacguuc agcgacaact t 21 <210> 738 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 738 guucuggagg agaugaaagt t 21 <210> 739 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 739 gcuggauaac uugaccuugt t 21 <210> 740 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 740 ggacuuuuug acaacaagct t 21 <210> 741 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 741 gaugaugacc uugaaguuct t 21 <210> 742 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 742 gagccaaccu gucgcaauct t 21 <210> 743 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 743 gcaugaacag guggagaaut t 21 <210> 744 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 744 ggauaaaauu caggauuuct t 21 <210> 745 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 745 gacggaagga gaguaguuat t 21 <210> 746 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 746 guggcaggcc accugagaut t 21 <210> 747 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 747 aaagccacuc cacucucuut t 21 <210> 748 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 748 gacuguacga caccuuuggt t 21 <210> 749 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 749 gcacaagagc aucgaggagt t 21 <210> 750 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 750 gauaaugccg cuggaacuut t 21 <210> 751 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 751 guccuggaag agcagagugt t 21 <210> 752 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 752 ggugcagagc uacgagaagt t 21 <210> 753 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 753 gguggcuuug cccuauaaat t 21 <210> 754 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 754 gaggaagaag uagacaacut t 21 <210> 755 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 755 gaugccuacu guugcgcuct t 21 <210> 756 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 756 guuccugagc cagauaacat t 21 <210> 757 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 757 gacgaguaug agacaucagt t 21 <210> 758 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 758 guggaagagc cacgaacagt t 21 <210> 759 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 759 gaaccguaca gugacaucat t 21 <210> 760 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 760 gagagugcua acugccaaat t 21 <210> 761 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 761 gacggugugc ucaugcggct t 21 <210> 762 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 762 gcgugccgua gacuguccat t 21 <210> 763 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 763 gcaguaccag aaaguagcat t 21 <210> 764 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 764 gcuggcuaau ggaggagugt t 21 <210> 765 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 765 gcuauucauu uccgagaact t 21 <210> 766 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 766 gguuaacacu gacaaagact t 21 <210> 767 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 767 gaauauccaa auaaaccact t 21 <210> 768 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 768 gaaaugagug guucuacaut t 21 <210> 769 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 769 guacguuuca ugaccaaaat t 21 <210> 770 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 770 guauaacauc aggauuccat t 21 <210> 771 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 771 gauugguuau acaaguguut t 21 <210> 772 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 772 gaagagccuu cucuccaaat t 21 <210> 773 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 773 gauagaagcu gagaagggut t 21 <210> 774 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 774 gaugcaacga gugcacuugt t 21 <210> 775 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 775 gucacaagcu guugaaucat t 21 <210> 776 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 776 gccuaagaac ucuaagcaut t 21 <210> 777 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 777 gagaggcaua acaaauacct t 21 <210> 778 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 778 cagucgcuau gaaguuuact t 21 <210> 779 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 779 gguuguggag gagcuaacut t 21 <210> 780 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 780 gagcgagauc cgaguuuact t 21 <210> 781 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 781 guuuuaugag gacaacggat t 21 <210> 782 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 782 gucuggcaag aagcccauut t 21 <210> 783 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 783 ggauguagga agagcuguut t 21 <210> 784 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 784 gaggcuccaa aaggaagaat t 21 <210> 785 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 785 ggaugcaccu guggaccaut t 21 <210> 786 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 786 guuccaucga ggacaagcct t 21 <210> 787 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 787 gcuaccgacu agaaauacut t 21 <210> 788 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 788 gaugcgcuuc uaucguuugt t 21 <210> 789 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 789 gccacagcua ggcaugauut t 21 <210> 790 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 790 gaagcguaug cggaagucat t 21 <210> 791 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 791 gaauuccucg ugaagagaut t 21 <210> 792 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 792 ggugucugug aucaaaguut t 21 <210> 793 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 793 gaacggcugc ugauaauuut t 21 <210> 794 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 794 gguuggaacu cgacugaugt t 21 <210> 795 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 795 guugugcagu guguuaacat t 21 <210> 796 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 796 gagacugguu gacacagaut t 21 <210> 797 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 797 ggaccuaaag aaccucaagt t 21 <210> 798 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 798 gcuauguucg ccauuaaugt t 21 <210> 799 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 799 gagguagcuc agaaaugugt t 21 <210> 800 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 800 gccucgagcu caucagaagt t 21 <210> 801 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 801 guguuggucu ggucauaugt t 21 <210> 802 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 802 gcagauaguu cuaccaguat t 21 <210> 803 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 803 ggaugagauu gcuuuaguct t 21 <210> 804 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 804 gagucuuguu auuucuucut t 21 <210> 805 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 805 ggaagaacau gcgauauact t 21 <210> 806 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 806 caaccuagag aaguaccaut t 21 <210> 807 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 807 gugauuucuu accagcaaut t 21 <210> 808 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 808 gaaguucaag ccuuggaugt t 21 <210> 809 <211> 21 <212> Combined DNA/RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 809 ggagcuacca gcagaauagt t 21 <210> 810 <211> 1800 <212> DNA <213> Homo sapiens <400> 810 atagtgtcac tcacaggcat cggctcaggc caggctcctc tagcccagtg tgtggccctg 60 gcccaaaggc caggcgtgcg gcagggctgg ctgaactgcc agcggttggt cattgacgag 120 atctcaatgg tggaggcaga cctgtttgac aaactggagg ccgtggccag agctgtccgg 180 cagcagaaca agccattcgg agggatccag ctcatcatct gtggggactt tctgcagctg 240 ccacctgtga ccaagggctc ccagccccca cggttctgct tccagtccaa gagctggaag 300 aggtgtgtgc cagtgaccct ggagctgacc aaggtgtgga ggcaggcaga ccagaccttc 360 atctctctac tgcaggccgt gaggctaggc aggtgttcag atgaggtgac ccgccagctc 420 caggccacag cttcccacaa ggtggggcga gatgggattg tggccacgag gctctgcacc 480 caccaggatg atgtggccct caccaacgag aggcggcttc aggagctgcc aggtaaggta 540 cacagatttg aggctatgga cagcaaccct gagctggcca gtaccctgga tgcccagtgt 600 cctgttagcc agctccttca actaaagctg ggggcccagg tgatgctggt gaaaaactta 660 tcggtgtctc ggggcctggt gaatggtgcc cgaggggtgg tagttgggtt cgaggcagaa 720 gggagagggc taccccaggt gcggttcctg tgtggagtca ctgaggtcat ccacgctgac 780 cgctggacgg tgcaggccac cgggggccag ctcctcagtc ggcagcagct gcccctccag 840 ctggcctggg cgatgtccat ccacaagagc caaggcatga ccctggattg tgtggagatt 900 tctctgggcc gtgtgtttgc cagtggccag gcctatgtgg ccctttctcg ggcccgcagc 960 ctgcagggcc tacgtgtgct ggactttgac cccatggcgg ttcgctgtga cccccgtgtg 1020 ctgcacttct atgccaccct gcggcggggc aggagcctca gtctggagtc cccagatgat 1080 gatgaggcag cctcagacca ggagaacatg gacccaaacc tctgagcctc acccacaaag 1140 agaagacaaa gggtggcctg tggcctcccc gtccttctgc tccctagtgg cccagggccc 1200 cagggaataa ctggagtagg caggcagtgt ccccttctgt attttttagg gactctcaac 1260 ctcctggcag ggttaaaggg agagtacttt aaacccatat accagctgtg cttcagtttc 1320 tctcactttg ccctgggtaa gctgctgtag ggtcagaagt aaccctttct gtgtcagttg 1380 agaatgagcc tgtgtggtag ctgatgtcag aggacaaagc tctctgcaag ggctggacac 1440 agagctgcag agtcctgaac atccctcctt tcaggctgca gaagggagag gcaatgaaga 1500 caggtgctcc ggaagcagca tcagggctct tggaggggac tggtggggac tcaggctggg 1560 tgcagcctcc aaacagagaa cggaacttag gtgtgtctct acagctaggc ccagcctagc 1620 ccagcccaga acaaacaccc ttcagagcct aaccaaagaa cataagctgc aaaatgtgca 1680 cccatatttt aagctgcttt ttcaggggat aaatagtgtt tggggacatt gaaatggatg 1740 ttctcaggtt gtatttattt cggacaaata aactagagaa ttgtgtaaaa aaaaaaaaaa 1800 <210> 811 <211> 1564 <212> DNA <213> Homo sapiens <400> 811 gttctgcttc cagtccaaga gctggaagag gtgtgtgcca gtgaccctgg agctgaccaa 60 ggtgtggagg caggcagacc agaccttcat ctctctactg caggccgtga ggctaggcag 120 gtgggctctg ccctgacagt ccagccccaa caggtgttca gatgaggtga cccgccagct 180 ccaggccaca gcttcccaca aggtggggcg agatgggatt gtggccacga ggctctgcac 240 ccaccaggat gatgtggccc tcaccaacga gaggcggctt caggagctgc caggtaaggt 300 acacagattt gaggctatgg acagcaaccc tgagctggcc agtaccctgg atgcccagtg 360 tcctgttagc cagctccttc aactaaagct gggggcccag gtgatgctgg tgaaaaactt 420 atcggtgtct cggggcctgg tgaatggtgc ccgaggggtg gtagttgggt tcgaggcaga 480 agggagaggg ctaccccagg tgcggttcct gtgtggagtc actgaggtca tccacgctga 540 ccgctggacg gtgcaggcca ccgggggcca gctcctcagt cggcagcagc tgcccctcca 600 gctggcctgg gcgatgtcca tccacaagag ccaaggcatg accctggatt gtgtggagat 660 ttctctgggc cgtgtgtttg ccagtggcca ggcctatgtg gccctttctc gggcccgcag 720 cctgcagggc ctacgtgtgc tggactttga ccccatggcg gttcgctgtg acccccgtgt 780 gctgcacttc tatgccaccc tgcggcgggg caggagcctc agtctggagt ccccagatga 840 tgatgaggca gcctcagacc aggagaacat ggacccaaac ctctgagcct cacccacaaa 900 gagaagacaa agggtggcct gtggcctccc cgtcctcctg ctccctagtg gcccagggcc 960 ccagggaata actggagtag gcaggcagtg tccccttctg tattttttag ggactctcag 1020 cctcctggca gggttaaagg gagagtactt taaacccata taccagctgt gcttcagttt 1080 ctctcacttt gccctgggta agctgctgta gggtcagaag taaccctttc tgtgccagtt 1140 gagaatgagc ctgtgtggta gctgatgtca gaggacaaag ctctctgcaa gggctggaca 1200 cagagctgca gagtcctgaa catccctcct ttcaggctgc agaagggaga ggcaatgaag 1260 acaggtgctc cggaagcagc atcagggctc ttggagggga ctggtgggga ctcaggctgg 1320 gtgcagcctc caaacagaga acggaactta ggtgtgtctc tacagctagg cccagcctag 1380 cccagcccag aacaaacacc cttcagagcc taaccaaaga acataagctg caaaatgtgc 1440 acccatattt taagctgctt tttcagggga taaatagtgt ttggggacat tgaaatggat 1500 gttctcaggt tgtatttatt tcggacaaat aaactagaga attgtgtaaa aaaaaaaaaa 1560 aaaa 1564 <210> 812 <211> 1668 <212> DNA <213> Homo sapiens <400> 812 actatctgct tgttcatctg agtgtcggca caaaccagca gaggcggtga cgatgctctc 60 gggcatagag gcggcggcag gggaatatga ggactcggag ctgcggtgcc gcgtggctgt 120 ggaggagctg agcccgggcg ggcagccgcg aaggcgccag gccctgcgca ccgcggagct 180 gagcctgggt cgcaacgagc gccgcgagtt gatgctgcgg ctgcaagcgc cagggcccgc 240 ggggcggccg cgctgcttcc ctctgcgcgc cgcgcgcctc ttcacgcgtt tcgccgaggc 300 cgggcgcagc accctgcggc tccccgccca cgacaccccc ggggccggcg cagtgcagct 360 gctgctctcg gactgccccc cagaccgcct gcgccgcttc ctgcgcacat tgcgcctcaa 420 gctggctgcg gccccgggtc ccgggccggc ctccgcccga gcgcagctgc tgggcccgcg 480 gccccgcgac ttcgtcacca tcagccctgt gcagcccgag gagcggcggc tcagggcggc 540 cacccgggtt ccggacacta cgctggtgaa gcggcctgtg gagccccagg ctggggccga 600 gcctagcaca gaagccccaa ggtggcccct gcctgtgaag aggctgagct tgccctccac 660 caagccacag ctttctgagg aacaggctgc tgtgctgagg gccgtcctga aaggccagag 720 catcttcttc actgggagtg caggtagtgg gggcagagag gaggtagggg gacagtggtg 780 gggtgggata gaggaacagg gagacctgtc taactttgcc cctgtccagg aacagggaag 840 tcatatctgc taaagcgaat cctgggctca ctgcccccca caggcactgt ggccactgcc 900 agcactgggg tggcagcctg ccacatcggg ggcaccaccc tccatgcctt tgcaggtaag 960 taggaacccc tagggcttga gctaagagca agcccagctt ctgggaaggg agagagggga 1020 ggtctgcata aagagggagt tttgggggct gggcgccgtg gctcactctt gtaatcccaa 1080 aactttagga ggccaaggtg ggaggatcgc ttgagcccag gagtttgaga ccagcctggc 1140 caacacagta aaccctgtct ccacaaaatt taaaaattag cggccgggcg cagtggctca 1200 cgcctgtaat cccagcactt tgggaggccg aggcaggcgg atcacaaggt caggagatca 1260 agactatcct ggctaacacg gtaaaaccct gtctctacta aaaatacaaa aaaattagcc 1320 aggcatggtg gcaagcgcct gtagtcccag ctactctgga ggctgaggca ggagaatggc 1380 gtgaacccag gaggcagagc ttgcagtgag ccgagatcac gccactgcac ttgagcctgg 1440 gcgacacagc gagactccat ctcaaaacaa aacaaaacaa aattagctga gcatggtggt 1500 gtgtgcctgt agtcccagct actatggagg ttgaggtggg aggatcgctt gagcccatga 1560 ggcccaggtt acagtgagcc aagatcgtgc cactgcactt cagcctgggt gacagaaaga 1620 gaccttctct caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa 1668 <210> 813 <211> 1668 <212> DNA <213> Homo sapiens <400> 813 actatctgct tgttcatctg agtgtcggca caaaccagca gaggcggtga cgatgctctc 60 gggcatagag gcggcggcag gggaatatga ggactcggag ctgcggtgcc gcgtggctgt 120 ggaggagctg agcccgggcg ggcagccgcg aaggcgccag gccctgcgca ccgcggagct 180 gagcctgggt cgcaacgagc gccgcgagtt gatgctgcgg ctgcaagcgc cagggcccgc 240 ggggcggccg cgctgcttcc ctctgcgcgc cgcgcgcctc ttcacgcgtt tcgccgaggc 300 cgggcgcagc accctgcggc tccccgccca cgacaccccc ggggccggcg cagtgcagct 360 gctgctctcg gactgccccc cagaccgcct gcgccgcttc ctgcgcacat tgcgcctcaa 420 gctggctgcg gccccgggtc ccgggccggc ctccgcccga gcgcagctgc tgggcccgcg 480 gccccgcgac ttcgtcacca tcagccctgt gcagcccgag gagcggcggc tcagggcggc 540 cacccgggtt ccggacacta cgctggtgaa gcggcctgtg gagccccagg ctggggccga 600 gcctagcaca gaagccccaa ggtggcccct gcctgtgaag aggctgagct tgccctccac 660 caagccacag ctttctgagg aacaggctgc tgtgctgagg gccgtcctga aaggccagag 720 catcttcttc actgggagtg caggtagtgg gggcagagag gaggtagggg gacagtggtg 780 gggtgggata gaggaacagg gagacctgtc taactttgcc cctgtccagg aacagggaag 840 tcatatctgc taaagcgaat cctgggctca ctgcccccca caggcactgt ggccactgcc 900 agcactgggg tggcagcctg ccacatcggg ggcaccaccc tccatgcctt tgcaggtaag 960 taggaacccc tagggcttga gctaagagca agcccagctt ctgggaaggg agagagggga 1020 ggtctgcata aagagggagt tttgggggct gggcgccgtg gctcactctt gtaatcccaa 1080 aactttagga ggccaaggtg ggaggatcgc ttgagcccag gagtttgaga ccagcctggc 1140 caacacagta aaccctgtct ccacaaaatt taaaaattag cggccgggcg cagtggctca 1200 cgcctgtaat cccagcactt tgggaggccg aggcaggcgg atcacaaggt caggagatca 1260 agactatcct ggctaacacg gtaaaaccct gtctctacta aaaatacaaa aaaattagcc 1320 aggcatggtg gcaagcgcct gtagtcccag ctactctgga ggctgaggca ggagaatggc 1380 gtgaacccag gaggcagagc ttgcagtgag ccgagatcac gccactgcac ttgagcctgg 1440 gcgacacagc gagactccat ctcaaaacaa aacaaaacaa aattagctga gcatggtggt 1500 gtgtgcctgt agtcccagct actatggagg ttgaggtggg aggatcgctt gagcccatga 1560 ggcccaggtt acagtgagcc aagatcgtgc cactgcactt cagcctgggt gacagaaaga 1620 gaccttctct caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa 1668 <210> 814 <211> 1154 <212> DNA <213> Homo sapiens <400> 814 cttgttcatc tgagtgtcgg cacaaaccag cagaggcggt gacgatgctc tcgggcatag 60 aggcggcggc aggggaatat gaggactcgg agctgcggtg ccgcgtggct gtggaggagc 120 tgagcccggg cgggcagccg cgaaggcgcc aggccctgcg caccgcggag ctgagcctgg 180 gtcgcaacga gcgccgcgag ttgatgctgc ggctgcaagc gccagggccc gcggggcggc 240 cgcgctgctt ccctctgcgc gccgcgcgcc tcttcacgcg tttcgccgag gccgggcgca 300 gcaccctgcg gctccccgcc cacgacaccc ccggggccgg cgcagtgcag ctgctgctct 360 cggactgccc cccagaccgc ctgcgccgct tcctgcgcac attgcgcctc aagctggctg 420 cggccccggg tcccgggccg gcctccgccc gagcgcagct gctgggcccg cggccccgcg 480 acttcgtcac catcagccct gtgcagcccg aggagcggcg gctcagggcg gccacccggg 540 ttccggacac tacgctggtg aagcggcctg tggagcccca ggctggggcc gagcctagca 600 cagtgaggac gggaaagaag ggacaccttt aggagtagat gtgccattct ttaagatggc 660 agagacctag agacccaagt ttgaggggaa gccggtgtgg gtatttgata cccatctgac 720 atctcagtat gacaggggtg tgggaattgt gcctgtggtt gttatagtgt aatccctgag 780 atggagtaaa tcaaaacagg aaatgggacc tggctacatt aaaagagaaa gcagaggccg 840 ggcatggtgg ctcacgcctg taatcccagc actttgggag gctaaagtgg atcacctgag 900 gttaggagtt ctgaggccag cctggccaac atggtgaagc ctcgtatcta ctaaaaatac 960 aaaaattagc caggcgcggt ggcgggcgcc tgtaatccca gctacttggg aggctgaggc 1020 aggagaatag cttgaacccg ggaggcagag gttgcagtga gcctagatcg cgccactgca 1080 ctccagcctg ggtgacagag cgagactctt cctcaaaaaa aaaaaaaaaa aaaaaaaaaa 1140 aaaaaaaaaa aaaa 1154 <210> 815 <211> 2304 <212> DNA <213> Homo sapiens <400> 815 acttccgggc cctgcgtggc agttgaaaga gtggcgggag aagttgcagg gaattatttg 60 atagcacata ctgatggctc taaagaagtc atcaccctca ctggattctg gtgatagtga 120 ctctgaggag ttgccaacat ttgcctttct gaagaaggaa ccatcttcaa caaagaggag 180 acagcctgaa agggaagaga agattgtagt ggttgacatc tcagattgtg aagcctcctg 240 tcctccagca ccagagttat tttcaccacc tgtcccagac atagctgaaa ctgtcacaca 300 aacacagcca gtcaggttgc taagcagtga aagtgaagat gaagaagaat ttattcctct 360 ggctcaaagg cttacatgta agtttctgac ccacaagcaa ctgagccctg aggactctag 420 ctccccagtt aaaagtgttt tggatcatca aaataatgaa ggtgcatcat gtgactggaa 480 aaagcccttt ccaaagatcc ctgaagttcc cctccatgat accccagaga ggagtgcagc 540 agataacaag gacctgatct tagatccatg ctgtcagctt ccagcctacc tgtctacctg 600 ccctggccag agcagcagct tggcagtaac caaaacaaat tctgacatcc ttccacccca 660 gaagaaaacc aagccgagtc agaaggtcca gggaagaggc tcacacggat gccagcagca 720 gagacaagca aggcagaagg aaagcaccct gagaagacag gaaagaaaga atgcagcact 780 ggttaccagg atgaaagccc agaggccaga ggaatgctta aaacacatca ttgtagtgct 840 ggatccagtg ctcttacaga tggaaggtgg gggccagctc ctaggagcac tgcagaccat 900 ggagtgccgc tgtgtgattg aggcgcaggc tgtgccttgc agtgtcactt ggaggagaag 960 ggctgggccg tctgaggaca gagaggactg ggtggaggag ccaacagtac tggtgttgct 1020 ccgggcagag gcatttgtgt ccatgatcga caatggaaag cagggaagcc tggacagcac 1080 tatgaaaggg aaggaaacgc ttcagggctt tgtaactgac atcacagcaa agacagcagg 1140 gaaagctctg tcactggtga ttgtggatca ggagaaatgc ttcagtgctc agaatcctcc 1200 aagaagaggg aaacagggag caaataaaca gaccaagaag cagcagcaga gacaaccaga 1260 ggccagcata gggtccatgg tatccagggt agacgctgaa gaggcattgg tggatctgca 1320 gctacacaca gaagcccagg ctcaaattgt gcagagctgg aaagagctgg ccgacttcac 1380 atgcgcattc acaaaggctg tggctgaggc gcccttcaag aagctccgag atgaaactac 1440 cttctccttc tgtctggaga gtgactgggc tggaggggtg aaggtggacc ttgctggcag 1500 gggactcgca ctagtctgga ggagacagat tcagcagctg aaccgagtca gcctggaaat 1560 ggccagtgca gttgtgaatg cctatccctc cccacagctc ctggtacagg cttatcagca 1620 gtgtttttcg gataaagaac gccagaattt gctcgcagac atacaggtgc gccgtgggga 1680 aggtgtgaca tccacttctc gccgcattgg accagaacta tccaggcgta tctaccttca 1740 gatgaccact ttacagccac atctctcttt agatagtgct gactgattct agccctcagg 1800 gatgaggatg aaaagctgga aacttccact tccccaacct cagagcctga ctgtaatgaa 1860 gagactggca gcacctcctg gaacacaagc ctaggtgagg cccagtcttt cttgggtctt 1920 attatttgtg aaggtctctc tgcctgtcgg ctggggcaga gactgaaata ctgccaccta 1980 cctttggcat ttaatgttcc tctcctggca aaaattcact gccacagaca aaccaccccc 2040 actcctaccc agccagccct caaaacacaa aggaacaaag acagtccact cagacactta 2100 tttaataact gtagaaatcc aaaagaatta gcatcaaatc ttgaagtcgt gagtgaagct 2160 gcgggttggc ttgactgggc tcagccactg agctgcctca accggccaag gaacgggatt 2220 atgatgacta tgcggacttc tatattgtct tcatctcatt gtgtgtatta tgtatttagt 2280 ttcaataaag catttgtacc aatg 2304 <210> 816 <211> 1438 <212> DNA <213> Homo sapiens <400> 816 ttctcctttc gcctatatgt aagtatgtgt tctgcaggct gatatcatag gccaggttac 60 cataggccaa gttaccagga ttaattacag gtcagatcac aatgtaataa gcactaggaa 120 agcaaatttt tggcctactc agttcaagaa gtgttcactg tcagaattta aaataagtaa 180 atgacctcag agacaatcca gtccaagtcc cttattttat acttgagggg actgaggcct 240 gaagagattg acttgtctaa gctcctagca gttagaagaa ccagaaatag attgcagatt 300 gccagatatc caaagaatct ggtatctttt cttctactat aatggactag atgtagtttt 360 taaatgaatc agcaactggc cctatacctg gcaacaaagt gagcactcaa attgtcaaag 420 gcacaaaaag gccagatgta acatggcgcc cacctcttcc aaggtcagtg ggggggtttt 480 cagttgccac ttgaggggaa caggtgtaga agagtagtga gcaacttaca gctctccaac 540 cacgctgttg caggaagctc cgagatgaaa ctaccttctc cttctgtctg gagagtgact 600 ggcctggagg ggtgaaggtg gaccttgctg gcaggggact cgcactagtc tggaggagac 660 agattcagca gctgaaccga gtcagcctgg aaatggccag tgcagttgtg aatgcctatc 720 cctccccaca gctcctggta caggcttatc agcagtgttt ttcggataaa gaacgccaga 780 atttgctcgc agacatacag gtgcgccgtg gggaaggtgt gacatccact tctcgccgca 840 ttggaccaga actatccagg cgtatctacc ttcagatgac cactttacag ccacatctct 900 ctttagatag tgctgactga ttctagccct cagggatgag gatgaaaagc tggaaacttc 960 cacttcccca acctcagagc ctgactgtaa tgaagagact ggcagcacct cctggaacac 1020 aagcctaggt gaggcccagt ctttcttggg tcttattatt tgtgaaggtc tctctgcctg 1080 tcggctgggg cagagactga aatactgcca cctacctttg gcatttaatg ttcctctcct 1140 ggcaaaaatt cactgccaca gacaaaccac ccccactcct acccagccag ccctcaaaac 1200 acaaaggaac aaagacagtc cactcagaca cttatttaat aactgtagaa atccaaaaga 1260 attagcatca aatcttgaag tcgtgagtga agctgcgggt tggcttgact gggctcagcc 1320 actgagctgc ctcaaccggc caaggaacgg gattatgatg actatgcgga cttctatatt 1380 gtcttcatct cattgtgtgt attatgtatt tagtttcaat aaagcatttg taccaatg 1438 <210> 817 <211> 2314 <212> DNA <213> Homo sapiens <400> 817 gggaattatt tgatagcaca tactgatggc tctaaagaag tcatcaccct cactggattc 60 tggtgatagt gactctgagg agttgccaac atttgccttt ctgaagaagg aaccatcttc 120 aacaaagagg agacagcctg aaagggaaga gaagattgta gtggttgaca tctcagattg 180 tgaagcctcc tgtcctccag caccagagtt attttcacca cctgtcccag acatagctga 240 aactgtcaca caaacacagc cagtcaggtt gctaagcagt gaaagtgaag atgaagaaga 300 atttattcct ctggctcaaa ggcttacatg taagtttctg acccacaagc aactgagccc 360 tgaggactct agctccccag ttaaaagtgt tttggatcat caaaataatg aaggtgcatc 420 atgtgactgg aaaaagccct ttccaaagat ccctgaagtt cccctccatg ataccccaga 480 gaggagtgca gcagataaca aggacctgat cttagatcca tgctgtcagc ttccagccta 540 cctgtctacc tgccctggcc agagcagcag cttggcagta accaaaacaa attctgacat 600 ccttccaccc cagaagaaaa ccaagccgag tcagaaggtc cagggaagag gctcacacgg 660 atgccggcag cagagacaag caaggcagaa ggaaagcacc ctgagaagac aggaaagaaa 720 gaatgcagca ctggttacca ggatgaaagc ccagaggcca gaggaatgct taaaacacat 780 cattgtagtg ctggatccag tgctcttaca gatggaaggt gggggccagc tcctaggagc 840 actgcagacc atggagtgcc gctgtgtgat tgaggcgcag gctgtgcctt gcagtgtcac 900 ttggaggaga agggctgggc cgtctgagga cagagaggac tgggtggagg agccaacagt 960 actggtgttg ctccgggcag aggcatttgt gtccatgatc gacaatggaa agcagggaag 1020 cctggacagc actatgaaag ggaaggaaac gcttcagggc tttgtaactg acatcacagc 1080 aaagacagca gggaaagctc tgtcactggt gattgtggat caggagaaat gcttcagcct 1140 ggagctgctg ttctttgatt tcctcccctg caccagtgct cagaatcctc caagaagagg 1200 gaaacaggga gcaaataaac agaccaagaa gcagcagcag agacaaccag aggccagcat 1260 agggtccatg gtatccaggg tagacgctga agaggcattg gtggatctgc agctacacac 1320 agaagcccag gctcaaattg tgcagagctg gaaagagctg gccgacttca catgcgcatt 1380 cacaaaggct gtggctgagg cgcccttcaa gaagctccga gatgaaacta ccttctcctt 1440 ctgtctggag agtgactggg ctggaggggt gaaggtggac cttgctggca ggggactcgc 1500 actagtctgg aggagacaga ttcagcagct gaaccgagtc agcctggaaa tggccagtgc 1560 agttgtgaat gcctatccct ccccacagct cctggtacag gcttatcagc agtgtttttc 1620 ggataaagaa cgccagaatt tgctcgcaga catacaggtg cgccgtgggg aaggtgtgac 1680 atccacttct cgccgcattg gaccagaact atccaggcgt atctaccttc agatgaccac 1740 tttacagcca catctctctt tagatagtgc tgactgattc tagccctcag ggatgaggat 1800 gaaaagctgg aaacttccac ttccccaacc tcagagcctg actgtaatga agagactggc 1860 agcacctcct ggaacacaag cctaggtgag gcccagtctt tcttgggtct tattatttgt 1920 gaaggtctct ctgcctgtcg gctggggcag agactgaaat actgccacct acctttggca 1980 tttaatgttc ctctcctggc aaaaattcac tgccacagac aaaccacccc cactcctacc 2040 cagccagccc tcaaaacaca aaggaacaaa gacagtccac tcagacactt atttaataac 2100 tgtagaaatc caaaagaatt agcatcaaat cttgaagtcg tgagtgaagc tgcgggttgg 2160 cttgactggg ctcagccact gagctgcctc aaccggccaa ggaacgggat tatgatgact 2220 atgcggactt ctatattgtc ttcatctcat tgtgtgtatt atgtatttag tttcaataaa 2280 gcatttgtac caatggcaaa aaaaaaaaaa aaaa 2314 <210> 818 <211> 2304 <212> DNA <213> Homo sapiens <400> 818 acttccgggc cctgcgtggc agttgaaaga gtggcgggag aagttgcagg gaattatttg 60 atagcacata ctgatggctc taaagaagtc atcaccctca ctggattctg gtgatagtga 120 ctctgaggag ttgccaacat ttgcctttct gaagaaggaa ccatcttcaa caaagaggag 180 acagcctgaa agggaagaga agattgtagt ggttgacatc tcagattgtg aagcctcctg 240 tcctccagca ccagagttat tttcaccacc tgtcccagac atagctgaaa ctgtcacaca 300 aacacagcca gtcaggttgc taagcagtga aagtgaagat gaagaagaat ttattcctct 360 ggctcaaagg cttacatgta agtttctgac ccacaagcaa ctgagccctg aggactctag 420 ctccccagtt aaaagtgttt tggatcatca aaataatgaa ggtgcatcat gtgactggaa 480 aaagcccttt ccaaagatcc ctgaagttcc cctccatgat accccagaga ggagtgcagc 540 agataacaag gacctgatct tagatccatg ctgtcagctt ccagcctacc tgtctacctg 600 ccctggccag agcagcagct tggcagtaac caaaacaaat tctgacatcc ttccacccca 660 gaagaaaacc aagccgagtc agaaggtcca gggaagaggc tcacacggat gccagcagca 720 gagacaagca aggcagaagg aaagcaccct gagaagacag gaaagaaaga atgcagcact 780 ggttaccagg atgaaagccc agaggccaga ggaatgctta aaacacatca ttgtagtgct 840 ggatccagtg ctcttacaga tggaaggtgg gggccagctc ctaggagcac tgcagaccat 900 ggagtgccgc tgtgtgattg aggcgcaggc tgtgccttgc agtgtcactt ggaggagaag 960 ggctgggccg tctgaggaca gagaggactg ggtggaggag ccaacagtac tggtgttgct 1020 ccgggcagag gcatttgtgt ccatgatcga caatggaaag cagggaagcc tggacagcac 1080 tatgaaaggg aaggaaacgc ttcagggctt tgtaactgac atcacagcaa agacagcagg 1140 gaaagctctg tcactggtga ttgtggatca ggagaaatgc ttcagtgctc agaatcctcc 1200 aagaagaggg aaacagggag caaataaaca gaccaagaag cagcagcaga gacaaccaga 1260 ggccagcata gggtccatgg tatccagggt agacgctgaa gaggcattgg tggatctgca 1320 gctacacaca gaagcccagg ctcaaattgt gcagagctgg aaagagctgg ccgacttcac 1380 atgcgcattc acaaaggctg tggctgaggc gcccttcaag aagctccgag atgaaactac 1440 cttctccttc tgtctggaga gtgactgggc tggaggggtg aaggtggacc ttgctggcag 1500 gggactcgca ctagtctgga ggagacagat tcagcagctg aaccgagtca gcctggaaat 1560 ggccagtgca gttgtgaatg cctatccctc cccacagctc ctggtacagg cttatcagca 1620 gtgtttttcg gataaagaac gccagaattt gctcgcagac atacaggtgc gccgtgggga 1680 aggtgtgaca tccacttctc gccgcattgg accagaacta tccaggcgta tctaccttca 1740 gatgaccact ttacagccac atctctcttt agatagtgct gactgattct agccctcagg 1800 gatgaggatg aaaagctgga aacttccact tccccaacct cagagcctga ctgtaatgaa 1860 gagactggca gcacctcctg gaacacaagc ctaggtgagg cccagtcttt cttgggtctt 1920 attatttgtg aaggtctctc tgcctgtcgg ctggggcaga gactgaaata ctgccaccta 1980 cctttggcat ttaatgttcc tctcctggca aaaattcact gccacagaca aaccaccccc 2040 actcctaccc agccagccct caaaacacaa aggaacaaag acagtccact cagacactta 2100 tttaataact gtagaaatcc aaaagaatta gcatcaaatc ttgaagtcgt gagtgaagct 2160 gcgggttggc ttgactgggc tcagccactg agctgcctca accggccaag gaacgggatt 2220 atgatgacta tgcggacttc tatattgtct tcatctcatt gtgtgtatta tgtatttagt 2280 ttcaataaag catttgtacc aatg 2304 <210> 819 <211> 4116 <212> DNA <213> Homo sapiens <400> 819 ggagaaggcg ggcggaagtt ccacgccaag atactggatt cggtgctgag gcggcggctg 60 cggcacggga aaggctcagt gactgaagct ccaaaggcca gcaggctggt ggggacgtga 120 ccgaagcgag gctctggttc cctttcggtg ggcgccattt gagcctcatc tctggcttcc 180 ccaggatgcg ccggcagccg gggagcggct ccgggcgcga ggtctgagga tgatctttcc 240 tgtcgcccgc tacgcgctcc ggtggctgcg acggcccgaa gaccgtgcct tttcccgcgc 300 cgccatggag atggccctcc gaggcgtgcg gaaagtcctc tgtgtggccg aaaaaaacga 360 cgcggccaag gggatcgccg acctgctgtc aaacggtcgc atgaggcgga gagaaggact 420 ttcaaaattc aacaagatct atgaatttga ttatcatctg tatggccaga atgttaccat 480 ggtaatgact tcagtttctg gacatttact ggctcatgat ttccagatgc agtttcgaaa 540 atggcagagc tgcaaccctc ttgtcctctt tgaagcagaa attgaaaagt actgcccaga 600 gaattttgta gacatcaaga aaactttgga acgagagact cgccagtgcc aggctctggt 660 gatctggact gactgtgata gagaaggcga aaacatcggg tttgagatta tccacgtgtg 720 taaggctgta aagcccaatc tgcaggtgtt gcgagcccga ttctctgaga tcacacccca 780 tgccgtcagg acagcttgtg aaaacctgac cgagcctgat cagagggtga gcgatgctgt 840 ggatgtgagg caggagctgg acctgaggat tggagctgcc tttactaggt tccagaccct 900 gcggcttcag aggatttttc ctgaggtgct ggcagagcag ctcatcagtt acggcagctg 960 ccagttcccc acactgggct ttgtggtgga gcggttcaaa gccattcagg cttttgtacc 1020 agaaatcttc cacagaatta aagtaactca tgaccacaaa gatggtatcg tagaattcaa 1080 ctggaaaagg catcgactct ttaaccacac ggcttgccta gttctctatc agttgtgtgt 1140 ggaggatccc atggcaactg tggtagaggt cagatctaag cccaagagca agtggcggcc 1200 tcaagccttg gacactgtgg agcttgagaa gctggcttct cgaaagttga gaataaatgc 1260 taaagaaacc atgaggattg ctgagaagct ctacactcaa gggtacatca gctatccccg 1320 aacagaaaca aacatttttc ccagagactt aaacctgacg gtgttggtgg aacagcagac 1380 ccccgatcca cgctgggggg cctttgccca gagcattcta gagcggggtg gtcccacccc 1440 acgcaatggg aacaagtctg accaagctca ccctcccatt caccccacca aatacaccaa 1500 caacttacag ggagatgaac agcgactgta cgagtttatt gttcgccatt tcctggcttg 1560 ctgctcccag gatgctcagg ggcaggagac cacagtggag atcgacatcg ctcaggaacg 1620 ctttgtggcc catggcctca tgattctggc ccgaaactat ctggatgtgt atccatatga 1680 tcactggagt gacaagatcc tccctgtcta tgagcaagga tcccactttc agcccagcac 1740 cgtggagatg gtggacgggg agaccagccc acccaagctg ctcaccgagg ccgacctcat 1800 tgccctcatg gagaagcatg gcattggtac ggatgccact catgcggagc acatcgagac 1860 catcaaagcc cggatgtacg tgggcctcac cccagacaag cggttcctcc ctgggcacct 1920 gggcatggga cttgtggaag gttatgattc catgggctat gaaatgtcta agcctgacct 1980 ccgggctgaa ctggaagctg atctgaagct gatctgtgat ggcaaaaagg acaaatttgt 2040 ggttctaagg cagcaagtgc agaaatacaa gcaggttttc attgaagcgg tggctaaagc 2100 aaagaaattg gacgaggcct tggcccagta ctttgggaat gggacagagt tggcccagca 2160 agaagatatc tacccagcca tgccagagcc catcaggaag tgcccacagt gcaacaagga 2220 catggtcctt aagaccaaga agaatggcgg gttctacctc agctgcatgg gtttcccaga 2280 gtgtcgctca gctgtgtggc ttcctgactc ggtgctggag gccagcaggg acagcagtgt 2340 gtgtccagtt tgtcagccac accctgtgta caggttaaag ttaaagttta agcgcggtag 2400 ccttcccccg accatgcctc tggagtttgt ttgctgcatc ggcggatgcg acgacaccct 2460 gagggagatc ctggacctga gattttcagg gggccccccc agggctagcc agccctctgg 2520 ccgcctgcag gctaaccagt ccctgaacag gatggacaac agccagcacc cccagcctgc 2580 tgacagcaga cagactgggt cctcaaaggc tctggcccag accctcccac cacccacggc 2640 tgctggtgaa agcaattctg tgacctgcaa ctgtggccag gaggctgtgc tgctcactgt 2700 ccgtaaggag ggccccaacc ggggccggca gttctttaag tgcaacggag gtagctgcaa 2760 cttcttcctg tgggcagaca gccccaatcc gggagcagga gggcctcctg ccttggcata 2820 tagacccctg ggcgcctccc tgggatgccc accaggccca gggatccacc taggtgggtt 2880 tggcaaccct ggtgatggca gtggtagtgg cacatcctgc ctttgcagcc agccctccgt 2940 cacacggact gtgcagaagg atggacccaa caaggggcgc cagttccaca catgtgccaa 3000 gccgagagag cagcagtgtg gctttttcca gtgggtcgat gagaacaccg ctccagggac 3060 ttctggagcc ccgtcctgga caggagacag aggaagaacc ctggagtcgg aagccagaag 3120 caaaaggccc cgggccagtt cctcagacat ggggtccaca gcaaagaaac cccggaaatg 3180 cagcctttgc caccagcctg gacacacccg tcccttttgt cctcagaaca gatgagctca 3240 gggtagggta gagaacgcca ctttctcaga cctgtcccct ttgtgtttag aaatgagtta 3300 accaggacca agtggccatt tagtgtcctg gaaacttaga ggacagtgtt ggcctttgga 3360 gtcgggcctt cttgtgttaa ggggcacaag gtccagatca ctctggagca ggccagctct 3420 gctggacagt gaccctcttc ccaggcctca ggagtgacca tagccactgc tgaaaagtca 3480 cgcagctgct ccctcggacc ccccaaggat ggttgctgtt agcagaggat tggtgcagtc 3540 ccagctgaag cccactgtgt gccaaaggaa gaagctccca gggctgcttc cttcacctgc 3600 agaaagcccc aagtgagcca ccagcactca tggggcagtc cctgtccagg ctgcccaggg 3660 cttctcatag acgtcctgag aaggacggtg taatgcaagg aaatggctgt ggtaacactg 3720 atccttcaga agaagcttca ttccctctta atctagttaa gccaggacat ccagaattca 3780 ttgctttaat aaagaaccca ggccgggtgc agtggctcat gcctgtaatc ccagcacttt 3840 gggaggctgt ggggggcgga ttgcctgagc tcaggagttc gagaccagcc agggcaacat 3900 ggtgaaaccc tgtctctact aaaatacaaa aaattagcca ggtgtggcgg tgtgcgcctg 3960 tagacccggc tactcaggag gctgaggcag gagaattgct tgaacccggg aggcggaggt 4020 tgcagttagc tgagattgcg ccactggacg acagagcgag actcagtctc aaaaaaaatt 4080 taaaaattta aaaaaataaa aagaatccaa ccccgg 4116 <210> 820 <211> 4072 <212> DNA <213> Homo sapiens <400> 820 ctggattcgg tgctgaggcg gcggctgcgg cacgggaaag gctcagtgac tgaagctcca 60 aaggccagca ggctggtggg gacgtgaccg aagcgaggct ctggttccct ttcggtgggc 120 gccatttgag cctcatctct ggcttcccca ggatgcgccg gcagccgggg agcggctccg 180 ggcgcgaggt ctgaggatga tctttcctgt cgcccgctac gcgctccggt ggctgcgacg 240 gcccgaagac cgtgcctttt cccgcgccgc catggagatg gccctccgag gcgtgcggaa 300 agtcctctgt gtggccgaaa aaaacgacgc ggccaagggg atcgccgacc tgctgtcaaa 360 cggtcgcatg aggcggagag aaggactttc aaaattcaac aagatctatg aatttgatta 420 tcatctgtat ggccagaatg ttaccatggt aatgacttca gtttctggac atttactggc 480 tcatgatttc cagatgcagt ttcgaaaatg gcagagctgc aaccctcttg tcctctttga 540 agcagaaatt gaaaagtact gcccagagaa ttttgtagac atcaagaaaa ctttggaacg 600 agagactcgc cagtgccagg ctctggtgat ctggactgac tgtgatagag aaggcgaaaa 660 catcgggttt gagattatcc acgtgtgtaa ggctgtaaag cccaatctgc aggtgttgcg 720 agcccgattc tctgagatca caccccatgc cgtcaggaca gcttgtgaaa acctgaccga 780 gcctgatcag agggtgagcg atgctgtgga tgtgaggcag gagctggacc tgaggattgg 840 agctgccttt actaggttcc agaccctgcg gcttcagagg atttttcctg aggtgctggc 900 agagcagctc atcagttacg gcagctgcca gttccccaca ctgggctttg tggtggagcg 960 gttcaaagcc attcaggctt ttgtaccaga aatcttccac agaattaaag taactcatga 1020 ccacaaagat ggtatcgtag aattcaactg gaaaaggcat cgactcttta accacacggc 1080 ttgcctagtt ctctatcagt tgtgtgtgga ggatcccatg gcaactgtgg tagaggtcag 1140 atctaagccc aagagcaagt ggcggcctca agccttggac actgtggagc ttgagaagct 1200 ggcttctcga aagttgagaa taaatgctaa agaaaccatg aggattgctg agaagctcta 1260 cactcaaggg tacatcagct atccccgaac agaaacaaac atttttccca gagacttaaa 1320 cctgacggtg ttggtggaac agcagacccc cgatccacgc tggggggcct ttgcccagag 1380 cattctagag cggggtggtc ccaccccacg caatgggaac aagtctgacc aagctcaccc 1440 tcccattcac cccaccaaat acaccaacaa cttacaggga gatgaacagc gactgtacga 1500 gtttattgtt cgccatttcc tggcttgctg ctcccaggat gctcaggggc aggagaccac 1560 agtggagatc gacatcgctc aggaacgctt tgtggcccat ggcctcatga ttctggcccg 1620 aaactatctg gatgtgtatc catatgatca ctggagtgac aagatcctcc ctgtctatga 1680 gcaaggatcc cactttcagc ccagcaccgt ggagatggtg gacggggaga ccagcccacc 1740 caagctgctc accgaggccg acctcattgc cctcatggag aagcatggca ttggtacgga 1800 tgccactcat gcggagcaca tcgagaccat caaagcccgg atgtacgtgg gcctcacccc 1860 agacaagcgg ttcctccctg ggcacctggg catgggactt gtggaaggtt atgattccat 1920 gggctatgaa atgtctaagc ctgacctccg ggctgaactg gaagctgatc tgaagctgat 1980 ctgtgatggc aaaaaggaca aatttgtggt tctaaggcag caagtgcaga aatacaagca 2040 ggttttcatt gaagcggtgg ctaaagcaaa gaaattggac gaggccttgg cccagtactt 2100 tgggaatggg acagagttgg cccagcaaga agatatctac ccagccatgc cagagcccat 2160 caggaagtgc ccacagtgca acaaggacat ggtccttaag accaagaaga atggcgggtt 2220 ctacctcagc tgcatgggtt tcccagagtg tcgctcagct gtgtggcttc ctgactcggt 2280 gctggaggcc agcagggaca gcagtgtgtg tccagtttgt cagccacacc ctgtgtacag 2340 gttaaagtta aagtttaagc gcggtagcct tcccccgacc atgcctctgg agtttgtttg 2400 ctgcatcggc ggatgcgacg acaccctgag ggagatcctg gacctgagat tttcaggggg 2460 cccccccagg gctagccagc cctctggccg cctgcaggct aaccagtccc tgaacaggat 2520 ggacaacagc cagcaccccc agcctgctga cagcagacag actgggtcct caaaggctct 2580 ggcccagacc ctcccaccac ccacggctgc tggtgaaagc aattctgtga cctgcaactg 2640 tggccaggag gctgtgctgc tcactgtccg taaggagggc cccaaccggg gccggcagtt 2700 ctttaagtgc aacggaggta gctgcaactt cttcctgtgg gcagacagcc ccaatccggg 2760 agcaggaggg cctcctgcct tggcatatag acccctgggc gcctccctgg gatgcccacc 2820 aggcccaggg atccacctag gtgggtttgg caaccctggt gatggcagtg gtagtggcac 2880 atcctgcctt tgcagccagc cctccgtcac acggactgtg cagaaggatg gacccaacaa 2940 ggggcgccag ttccacacat gtgccaagcc gagagagcag cagtgtggct ttttccagtg 3000 ggtcgatgag aacaccgctc cagggacttc tggagccccg tcctggacag gagacagagg 3060 aagaaccctg gagtcggaag ccagaagcaa aaggccccgg gccagttcct cagacatggg 3120 gtccacagca aagaaacccc ggaaatgcag cctttgccac cagcctggac acacccgtcc 3180 cttttgtcct cagaacagat gagctcaggg tagggtagag aacgccactt tctcagacct 3240 gtcccctttg tgtttagaaa tgagttaacc aggaccaagt ggccatttag tgtcctggaa 3300 acttagagga cagtgttggc ctttggagtc gggccttctt gtgttaaggg gcacaaggtc 3360 cagatcactc tggagcaggc cagctctgct ggacagtgac cctcttccca ggcctcagga 3420 gtgaccatag ccactgctga aaagtcacgc agctgctccc tcggaccccc caaggatggt 3480 tgctgttagc agaggattgg tgcagtccca gctgaagccc actgtgtgcc aaaggaagaa 3540 gctcccaggg ctgcttcctt cacctgcaga aagccccaag tgagccacca gcactcatgg 3600 ggcagtccct gtccaggctg cccagggctt ctcatagacg tcctgagaag gacggtgtaa 3660 tgcaaggaaa tggctgtggt aacactgatc cttcagaaga agcttcattc cctcttaatc 3720 tagttaagcc aggacatcca gaattcattg ctttaataaa gaacccaggc cgggtgcagt 3780 ggctcatgcc tgtaatccca gcactttggg aggctgtggg gggcggattg cctgagctca 3840 ggagttcgag accagccagg gcaacatggt gaaaccctgt ctctactaaa atacaaaaaa 3900 ttagccaggt gtggcggtgt gcgcctgtag acccggctac tcaggaggct gaggcaggag 3960 aattgcttga acccgggagg cggaggttgc agttagctga gattgcgcca ctggacgaca 4020 gagcgagact cagtctcaaa aaaaaattta aaaatttaaa aaaaaaaaaa aa 4072 <210> 821 <211> 3197 <212> DNA <213> Homo sapiens <400> 821 cttatcagtc ctgttcacac tcttggagaa gtggacagtg tgtcatgcag agggtcatag 60 ccttactttc aattcaccgg gaccttttct tttggggata caccatgaac ccattggaac 120 agtttgctgt cattagattg gagggctctc tgtcatgtac tgagttggga ctctgttttc 180 atttcttttc taggcagagc tgcaaccctc ttgtcctctt tgaagcagaa attgaaaagt 240 actgcccaga gaattttgta gacatcaaga aaactttgga acgagagact cgccagtgcc 300 aggctctggt gatctggact gactgtgata gagaaggcga aaacatcggg tttgagatta 360 tccacgtgtg taaggctgta aagcccaatc tgcaggtgtt gcgagcccga ttctctgaga 420 tcacacccca tgccgtcagg acagcttgtg aaaacctgac cgagcctgat cagagggtga 480 gcgatgctgt ggatgtgagg caggagctgg acctgaggat tggagctgcc tttactaggt 540 tccagaccct gcggcttcag aggatttttc ctgaggtgct ggcagagcag ctcatcagtt 600 acggcagctg ccagttcccc acactgggct ttgtggtgga gcggttcaaa gccattcagg 660 cttttgtacc agaaatcttc cacagaatta aagtaactca tgaccacaaa gatggtatcg 720 tagaattcaa ctggaaaagg catcgactct ttaaccacac ggcttgccta gttctctatc 780 agttgtgtgt ggaggatccc atggcaactg tggtagaggt cagatctaag cccaagagca 840 agtggcggcc tcaagccttg gacactgtgg agcttgagaa gctggcttct cgaaagttga 900 gaataaatgc taaagaaacc atgaggattg ctgagaagct ctacactcaa gggtacggat 960 gccactcatg cggagcacat cgagaccatc aaagcccgga tgtacgtggg cctcacccca 1020 gacaagcggt tcctccctgg gcacctgggc atgggacttg tggaaggtta tgattccatg 1080 ggctatgaaa tgtctaagcc tgacctccgg gctgaactgg aagctgatct gaagctgatc 1140 tgtgatggca aaaaggacaa atttgtggtt ctaaggcagc aagtgcagaa atacaagcag 1200 gttttcattg aagcggtggc taaagcaaag aaattggacg aggccttggc ccagtacttt 1260 gggaatggga cagagttggc ccagcaagaa gatatctacc cagccatgcc agagcccatc 1320 aggaagtgcc cacagtgcaa caaggacatg gtccttaaga ccaagaagaa tggcgggttc 1380 tacctcagct gcatgggttt cccagagtgt cgctcagctg tgtggcttcc tgactcggtg 1440 ctggaggcca gcagggacag cagtgtgtgt ccagtttgtc agccacaccc tgtgtacagg 1500 ttaaagttaa agtttaagcg cggtagcctt cccccgacca tgcctctgga gtttgtttgc 1560 tgcatcggcg gatgcgacga caccctgagg gagatcctgg acctgagatt ttcagggggc 1620 ccccccaggg ctagccagcc ctctggccgc ctgcaggcta accagtccct gaacaggatg 1680 gacaacagcc agcaccccca gcctgctgac agcagacaga ctgggtcctc aaaggctctg 1740 gcccagaccc tcccaccacc cacggctgct ggtgaaagca attctgtgac ctgcaactgt 1800 ggccaggagg ctgtgctgct cactgtccgt aaggagggcc ccaaccgggg ccggcagttc 1860 tttaagtgca acggaggtag ctgcaacttc ttcctgtggg cagacagccc caatccggga 1920 gcaggagggc ctcctgcctt ggcatataga cccctgggcg cctccctggg atgcccacca 1980 ggcccaggga tccacctagg tgggtttggc aaccctggtg atggcagtgg tagtggcaca 2040 tcctgccttt gcagccagcc ctccgtcaca cggactgtgc agaaggatgg acccaacaag 2100 gggcgccagt tccacacatg tgccaagccg agagagcagc agtgtggctt tttccagtgg 2160 gtcgatgaga acaccgctcc agggacttct ggagccccgt cctggacagg agacagagga 2220 agaactctgg agtcggaagc cagaagcaaa aggccccggg ccagttcctc agacatgggg 2280 tccacagcaa agaaaccccg gaaatgcagc ctttgccacc agcctggaca cacccgtccc 2340 ttttgtcctc agaacagatg agctcagggt agggtagaga acgccacttt ctcagacctg 2400 tcccctttgt gtttagaaat gagttaacca ggaccaagtg gccatttagt gtcctggaaa 2460 cttacgagga cagtgttggc ctttggagtc gggccttctt gtgttaagga gcacaaggtc 2520 cagatcactc tggagcaggc cagctctgct ggacagtgac cctcttccca ggcctcagga 2580 gtgaccatag ccactgctga aaagtcacgc agctgctccc tcggaccccc caaggatggt 2640 tgctgttagc agaggattgg tgcagtccca gctgaagccc actgtgtgcc aaaggaagaa 2700 gctcccaggg ctgcttcctt cacctgcaga aagccccaag tgagccacca gcactcatgg 2760 ggcagtccct gtccaggctg cccagggctt ctcatagacg tcctgagaag gacggtgtaa 2820 tgcaaggaaa tggctgtggt aacactgatc cttcagaaga agcttcattc cctcttaatc 2880 tagttaagcc aggacatcca gaattcattg ctttaataaa gaacccaggc cgggtgcagt 2940 ggctcgtgcc tgtaatccca gcactttggg aggctgtggg gggcggattg cctgagctcg 3000 ggagttcgag accagccggg gcagcatggt gaaaccctgt ctctactgaa atacagaaaa 3060 ttggccaggt gtggcggtgt gcgcctgtag acccggctgc tcgggaggct gaggcaggag 3120 aattgcttgg acccgggagg cggaggttgc ggttagctga gattgcgcca ctggacgaca 3180 gagcgagact cagtctc 3197 <210> 822 <211> 3755 <212> DNA <213> Homo sapiens <400> 822 ggcggctgcg gcacgggaaa ggctcagtga ctgaagctcc aaaggccagc aggctggtgg 60 ggacgtgacc gaagcgaggc tctggttccc tttcggtggg cgccatttga gcctcatctc 120 tggcttcccc aggatgcgcc ggcagccggg gagcggctcc gggcgcgagg tctgaggatg 180 atctttcctg tcgcccgcta cgcgctccgg tggctgcgac ggcccgaaga ccgtgccttt 240 tcccgcgccg ccatggagat ggccctccga ggcgtgcgga aagtcctctg tgtggccgaa 300 aaaaacgacg cggccaaggg gatcgccgac ctgctgtcaa acggtcgcat gaggcggaga 360 gaaggacttt caaaattcaa caagatctat gaatttgatt atcatctgta tggccagaat 420 gttaccatgg taatgacttc agtttctgga catttactgg ctcatgattt ccagatgcag 480 tttcgaaaat ggcagagctg caaccctctt gtcctctttg aagcagaaat tgaaaagtac 540 tgcccagaga attttgtaga catcaagaaa actttggaac gagagactcg ccagtgccag 600 gctctggtga tctggactga ctgtgataga gaaggcgaaa acatcgggtt tgagattatc 660 cacgtgtgta aggctgtaaa gcccaatctg caggtgttgc gagcccgatt ctctgagatc 720 acaccccatg ccgtcaggac agcttgtgaa aacctgaccg agcctgatca gagggtgagc 780 gatgctgtgg atgtgaggca ggagctggac ctgaggattg gagctgcctt tactaggttc 840 cagaccctgc ggcttcagag gatttttcct gaggtgctgg cagagcagct catcagttac 900 ggcagctgcc agttccccac actgggcttt gtggtggagc ggttcaaagc cattcaggct 960 tttgtaccag aaatcttcca cagaattaaa gtaactcatg accacaaaga tggtatcgta 1020 gaattcaact ggaaaaggca tcgactcttt aaccacacgg cttgcctagt tctctatcag 1080 ttgtgtgtgg aggatcccat ggcaactgtg gtagaggtca gatctaagcc caagagcaag 1140 tggcggcctc aagccttgga cactgtggag cttgagaagc tggcttctcg aaagttgaga 1200 ataaatgcta aagaaaccat gaggattgct gagaagctct acactcaagg gtacatcagc 1260 tatccccgaa cagaaacaaa catttttccc agagacttaa acctgacggt gttggtggaa 1320 cagcagaccc ccgatccacg ctggggggcc tttgcccaga gcattctaga gcggggtggt 1380 cccaccccac gcaatgggaa caagtctgac caagctcacc ctcccattca ccccaccaaa 1440 tacaccaaca acttacaggg agatgaacag cgactgtacg agtttattgt tcgccatttc 1500 ctggcttgct gctcccagga tgctcagggg caggagacca cagtggagat cgacatcgct 1560 caggaacgct ttgtggccca tggcctcatg attctggccc gaaactatct ggatgtgtat 1620 ccatatgatc actggagtga caagatcctc cctgtctatg agcaaggatc ccactttcag 1680 cccagcaccg tggagatggt ggacggggag accagcccac ccaagctgct caccgaggcc 1740 gacctcattg ccctcatgga gaagcatggc attggtacgg atgccactca tgcggagcac 1800 atcgagacca tcaaagcccg gatgtacgtg ggcctcaccc cagacaagcg gttcctccct 1860 gggcacctgg gcatgggact tgtggaaggt tatgattcca tgggctatga aatgtctaag 1920 cctgacctcc gggctgaact ggaagctgat ctgaagctga tctgtgatgg caaaaaggac 1980 aaatttgtgg ttctaaggca gcaagtgcag aaatacaagc aggttttcat tgaagcggtg 2040 gctaaagcaa agaaattgga cgaggccttg gcccagtact ttgggaatgg gacagagttg 2100 gcccagcaag aagatatcta cccagccatg ccagagccca tcaggaagtg cccacagtgc 2160 aacaaggaca tggtccttaa gaccaagaag aatggcgggt tctacctcag ctgcatgggt 2220 ttcccagagt gtcgctcagc tgtgtggctt cctgactcgg tgctggaggc cagcagggac 2280 agcagtgtgt gtccagtttg tcagccacac cctgtgtaca ggttaaagtt aaagtttaag 2340 cgcggtagcc ttcccccgac catgcctctg gagtttgttt gctgcatcgg cggatgcgac 2400 gacaccctga gggagatcct ggacctgaga ttttcagggg gcccccccag ggctagccag 2460 ccctctggcc gcctgcaggc taaccagtcc ctgaacagga tggacaacag ccagcacccc 2520 cagcctgctg acagcagaca gactgggtcc tcaaaggctc tggcccagac cctcccacca 2580 cccacggctg ctggtgaaag caattctgtg acctgcaact gtggccagga ggctgtgctg 2640 ctcactgtcc gtaaggaggg ccccaaccgg ggccggcagt tctttaagtg caacggaggt 2700 agctgcaact tcttcctgtg ggcagacagc cccaatccgg gagcaggagg gcctcctgcc 2760 ttggcatata gacccctggg cgcctccctg ggatgcccac caggcccagg gatccaccta 2820 ggtgggtttg gcaaccctgg tgatggcagt ggtagtggca catcctgcct ttgcagccag 2880 ccctccgtca cacggactgt gcagaaggat ggacccaaca aggggcgcca gttccacaca 2940 tgtgccaagc cgagagagca gcagtgtggc tttttccagt gggtcgatga gaacaccgct 3000 ccagggactt ctggagcccc gtcctggaca ggagacagag gaagaaccct ggagtcggaa 3060 gccagaagca aaaggccccg ggccagttcc tcagacatgg ggtccacagc aaagaaaccc 3120 cggaaatgca gcctttgcca ccagcctgga cacacccgtc ccttttgtcc tcagaacaga 3180 tgagctcagg gtagggtaga gaacgccact ttctcagacc tgtccccttt gtgtttagaa 3240 atgagttaac caggaccaag tggccattta gtgtcctgga aacttagagg acagtgttgg 3300 cctttggagt cgggccttct tgtgttaagg ggcacaaggt ccagatcact ctggagcagg 3360 ccagctctgc tggacagtga ccctcttccc aggcctcagg agtgaccata gccactgctg 3420 aaaagtcacg cagctgctcc ctcggacccc ccaaggatgg ttgctgttag cagaggattg 3480 gtgcagtccc agctgaagcc cactgtgtgc caaaggaaga agctcccagg gctgcttcct 3540 tcacctgcag aaagccccaa gtgagccacc agcactcatg gggcagtccc tgtccaggct 3600 gcccagggct tctcatagac gtcctgagaa ggacggtgta atgcaaggaa atggctgtgg 3660 taacactgat ccttcagaag aagcttcatt ccctcttaat ctagttaagc caggacatcc 3720 agaattcatt gctttaataa agaacccagg ccggg 3755 <210> 823 <211> 2343 <212> DNA <213> Homo sapiens <400> 823 gtctcaaagg ctggctggag tggagccaaa ggaaaagatc gttagagaca gcgcccctga 60 ccaaccactt agagcagcgc aggggtggga gggcggccgc aggctctcct ctcgttagtg 120 ccccctgtgt ttggggcccc gtgatctcaa cggtcctgcc ctcggtctcc ctcttccccc 180 gccccgccct gggccaggtg ttcgaatccc gactccagaa ctggcggcgt cccagtcccg 240 cgggcgtgga gcgccggagg acccgccctc gggctcatgg cggccccggt ccgcctgggc 300 cggaagcgcc cgctgcctgc ctgtcccaac ccgctcttcg ttcgctggct gaccgagtgg 360 cgggacgagg cgacccgcag caggcaccgc acgcgcttcg tatttcagaa ggcgctgcgt 420 tccctccgac ggtacccact gccgctgcgc agcgggaagg aagctaagat cctacagcac 480 ttcggagacg ggctctgccg gatgctggac gagcggctgc agcggcaccg aacatcgggc 540 ggtgaccatg ccccggactc accatctgga gagaacagtc cagccccgca ggggcgactt 600 gcggaagtcc aggactcttc catgccagtt cctgcccagc ccaaagcggg aggctctggc 660 agctactggc cagctcggca ctcaggagcc cgagtgatac tgctggtgct ctaccgggag 720 cacctgaatc ctaatggtca ccacttctta accaaggagg agctgctgca gaggtgtgct 780 cagaagtccc ccagggtagc ccctgggagt gccccaccct ggccagccct ccgctccctc 840 cttcacagga acctggtcct caggacacac cagccagcca ggtactcatt gaccccagag 900 ggcctggagc tggcccagaa gttggccgag tcagaaggcc tgagcttgct gaatgtgggc 960 atcgggccca aggagccccc tggggaggag acagcagtgc caggagcagc ttcagcagag 1020 cttgccagtg aagcaggggt ccagcagcag ccactggagc tgaggcctgg agagtacagg 1080 gtgctgttgt gtgtggacat tggcgagacc cgggggggcg ggcacaggcc ggagctgctc 1140 cgagagctac agcggctgca cgtgacccac acggtgcgca agctgcacgt tggagatttt 1200 gtgtgggtgg ctcaggagac caatcctaga gacccagcaa accctgggga gttggtactg 1260 gatcacattg tggagcgcaa gcgactggat gacctttgca gcagcatcat cgacggccgc 1320 ttccgggagc agaagttccg actgaagcgc tgtggtctgg agcgccgggt atacctggtg 1380 gaagagcatg gttccgtcca caacctcagc cttcctgaga gcacactgct gcaggctgtc 1440 accaacactc aggtcattga tggctttttt gtgaagcgca cagcagacat taaggagtca 1500 gccgcctacc tggccctctt gactcggggc ctgcagagac tctaccaggg ccacacccta 1560 cgcagccgcc cctggggaac ccctgggaac cctgaatcag gggccatgac ctctccaaac 1620 cctctctgct cactcctcac cttcagtgac ttcaacgcag gagccatcaa gaataaggcc 1680 cagtcggtgc gagaagtgtt tgcccggcag ctgatgcagg tgcgcggagt gagtggggag 1740 aaggcagcag ccctggtgga tcgatacagc acccctgcca gcctcctggc cgcctatgat 1800 gcctgtgcca cccccaagga acaagagaca ctgctgagca ccattaagtg tgggcgtcta 1860 cagaggaatc tggggcctgc tctgagcagg accttatccc agctctactg cagctacggc 1920 cccttgacct gagcttatgc cgtgaaacag cccccagccc ccgtctgtcc cccaacccag 1980 gctagccagc cttttaacaa catcttttgg ggtacaatta gaatctaagt gtttgcagcc 2040 atatgtgtca tgtagaagat gcctagccct ggggaccttg tgaaatacgc aggaaccagg 2100 gataccatct ggtccagtgg tttttaaaca aagctgctta gcacctggaa ttccctggtc 2160 agggagatgg agtcagtggg gcattgcagc ttggaatcta ttttatgtca ccagttggtc 2220 ctcatcaaat aaaatttcct taggagtgca gagggctcat tgggaaaata aaaataataa 2280 aaataaataa aacttcctaa aagaaaagat tgaaacccaa aaaaaaaaaa aaaaaaaaaa 2340 aaa 2343 <210> 824 <211> 2361 <212> DNA <213> Homo sapiens <400> 824 aaaagacccc gctctcgaat ctggggtgac aggaaggagc cggtccaggc tccgggggct 60 gggaaagagc gcgtctcaaa ggctggctgg agtggagcca agggaaaaga tcgttagaga 120 cagcgcccct gaccaaccac ttagagcagc gcaggggtgg gagggcggcc gcaggctctc 180 ctctcgttag tgccccctgt gtttggggcc ccgtgatctc aacggtcctg ccctcggtct 240 ccctcttccc ccgccccgcc ctgggccagg tgttcgaatc ccgcgggcgt ggagcgccgg 300 aggacccgcc ctcgggctca tggcggcccc ggtccgcctg ggccggaagc gcccgctgcc 360 tgcctgtccc aacccgctct tcgttcgctg gctgaccgag tggcgggacg aggcgacccg 420 cagcaggcac cgcacgcgct tcgtatttca gaaggcgctg cgttccctcc gacggtaccc 480 actgccgctg cgcagcggga aggaagctaa gatcctacag cacttcggag acgggctctg 540 ccggatgctg gacgagcggc tgcagcggca ccgaacatcg ggcggtgacc atgccccgga 600 ctcaccatct ggagagaaca gtccagcccc gcaggggcga cttgcggaag tccaggactc 660 ttccatgcca gttcctgccc agcccaaagc gggaggctct ggcagctact ggccagctcg 720 gcactcagga gcccgagtga tactgctggt gctctaccgg gagcacctga atcctaatgg 780 tcaccacttc ttaaccaagg aggagctgct gcagaggtgt gctcagaagt cccccagggt 840 agcccctggg agtgccccac cctggccagc cctccgctcc ctccttcaca ggaacctggt 900 cctcaggaca caccagccag ccaggtactc attgacccca gagggcctgg agctggccca 960 gaagttggcc gagtcagaag gcctgagctt gctgaatgtg ggcatcgggc ccaaggagcc 1020 ccctggggag gagacagcag tgccaggagc agcttcagca gagcttgcca gtgaagcagg 1080 ggtccagcag cagccactgg agctgaggcc tggagagtac agggtgctgt tgtgtgtgga 1140 cattggcgag acccgggggg gcgggcacag gccggagctg ctccgagagc tacagcggct 1200 gcacgtgacc cacacggtgc gcaagctgca cgttggagat tttgtgtggg tggctcagga 1260 gaccaatcct agagacccag caaaccctgg ggagttggta ctggatcaca ttgtggagcg 1320 caagcgactg gatgaccttt gcagcagcat catcgacggc cgcttccggg agcagaagtt 1380 ccgactgaag cgctgtggtc tggagcgccg ggtatacctg gtggaagagc atggttccgt 1440 ccacaacctc agccttcctg agagcacact gctgcaggct gtcaccaaca ctcaggtcat 1500 tgatggcttt tttgtgaagc gcacagcaga cattaaggag tcagccgcct acctggccct 1560 cttgactcgg ggcctgcaga gactctacca gggccacacc ctacgcagcc gcccctgggg 1620 aacccctggg aaccctgaat caggggccat gacctctcca aaccctctct gctcactcct 1680 caccttcagt gacttcaacg caggagccat caagaataag gcccagtcgg tgcgagaagt 1740 gtttgcccgg cagctgatgc aggtgcgcgg agtgagtggg gagaaggcag cagccctggt 1800 ggatcgatac agcacccctg ccagcctcct ggccgcctat gatgcctgtg ccacccccaa 1860 ggaacaagag acactgctga gcaccattaa gtgtgggcgt ctacagagga atctggggcc 1920 tgctctgagc aggaccttat cccagctcta ctgcagctac ggccccttga cctgagctta 1980 tgccgtgaaa cagcccccag cccccgtctg tcccccaacc caggctagcc agccttttaa 2040 caacatcttt tggggtacaa ttagaatcta agtgtttgca gccatatgtg tcatgtagaa 2100 gatgcctagc cctggggacc ttgtgaaata cgcaggaacc agggatacca tctggtccag 2160 tggtttttaa acaaagctgc ttagcacctg gaattccctg gtcagggaga tggagtcagt 2220 ggggcattgc agcttggaat ctattttatg tcaccagttg gtcctcatca aataaaattt 2280 ccttaggagt gcagagggct cattgggaaa ataaaaataa taaaaataaa taaaacttcc 2340 taaaagaaaa gattgaaaac c 2361 <210> 825 <211> 1817 <212> DNA <213> Homo sapiens <400> 825 ggcgccgcac gcgcttcgta tttcagaagg cgctgcgttc cctccgacgg tacccactgc 60 cgctgcgcag cgggaaggaa gctaagatcc tacagcactt cggagacggg ctctgccgga 120 tgctggacga gcggctgcag cggcaccgaa catcgggcgg tgaccatgcc ccggactcac 180 catctggaga gaacagtcca gccccgcagg ggcgacttgc ggaagtccag gactcttcca 240 tgccagttcc tgcccagccc aaagcgggag gctctggcag ctactggcca gctcggcact 300 caggagcccg agtgatactg ctggtgctct accgggagca cctgaatcct aatggtcacc 360 acttcttaac caaggaggag ctgctgcaga ggtgtgctca gaagtccccc agggtagccc 420 ctgggagtgc tcgaccctgg ccagccctcc gctccctcct tcacaggaac ctggtcctca 480 ggacacacca gccagccagg tactcattga ccccagaggg cctggagctg gcccagaagt 540 tggccgagtc agaaggcctg agcttgctga atgtgggcat cgggcccaag gagccccctg 600 gggaggagac agcagtgcca ggagcagctt cagcagagct tgccagtgaa gcaggggtcc 660 agcagcagcc actggagctg aggcctggag agtacagggt gctgttgtgt gtggacattg 720 gcgagacccg ggggggcggg cacaggccgg agctgctccg agagctacag cggctgcacg 780 tgacccacac ggtgcgcaag ctgcacgttg gagattttgt gtgggtggcc caggagacca 840 atcctagaga cccagcaaac cctggggagt tggtactgga tcacattgtg gagcgcaagc 900 gactggatga cctttgcagc agcatcatcg acggccgctt ccgggagcag aagttccggc 960 tgaagcgctg tggtctggag cgccgggtat acctggtgga agagcatggt tccgtccaca 1020 acctcagcct tcctgagagc acactgctgc aggctgtcac caacactcag gtcattgatg 1080 gcttttttgt gaagcgcaca gcagacatta aggagtcagc cgcctacctg gccctcttga 1140 cgcggggcct gcagagactc taccagtgac ttcaacgcag gagccatcaa gaataaggcc 1200 cagtcggtgc gagaagtgtt tgcccggcag ctgatgcagg tgcgcggagt gagtggggag 1260 aaggcagcag ccctggtgga tcgatacagc acccctgcca gcctcctggc cgcctatgat 1320 gcctgtgcca cccccaagga acaagagaca ctgctgagca ccattaagtg tgggcgtcta 1380 cagaggaatc tggggcctgc tctgagcagg accttatccc agctctactg cagctacggc 1440 cccttgacct gagcttatgc cgtgaaacag cccccagccc ccgtctgtcc cccaacccag 1500 gctagccagc cttttaacaa catcttttgg ggtacaatta gaatctaagt gtttgcagcc 1560 atatgtgtca tgtagaagat gcctagccct ggggaccttg tgaaatacgc aggaaccagg 1620 gataccatct ggtccagtgg tttttaaaca aagctgctta gcacctggaa ttccctggtc 1680 agggagatgg agtcagtggg gcattgcagc ttggaatcta ttttatgtca ccagttggtc 1740 ctcatcaaat aaaatttcct taggagtgca gagggctcat tgggaaaata aaaataataa 1800 aaataaataa aacttcc 1817 <210> 826 <211> 2148 <212> DNA <213> Homo sapiens <400> 826 gtgatctcaa cggtcctgcc ctcggtctcc ctcttccccc gccccgccct gggccaggtg 60 ttcgaatccc gactccagaa ctggcggcgt cccagtcccg cgggcgtgga gcgccggagg 120 acccgccctc gggctcatgg cggccccggt ccgcctgggc cggaagcgcc cgctgcctgc 180 ctgtcccaac ccgctcttcg ttcgctggct gaccgagtgg cgggacgagg cgacccgcag 240 caggcgccgc acgcgcttcg tatttcagaa ggcgctgcgt tccctccgac ggtacccact 300 gccgctgcgc agcgggaagg aagctaagat cctacagcac ttcggagacg ggctctgccg 360 gatgctggac gagcggctgc agcggcaccg aacatcgggc ggtgaccatg ccccggactc 420 accatctgga gagaacagtc cagccccgca ggggcgactt gcggaagtcc aggactcttc 480 catgccagtt cctgcccagc ccaaagcggg aggctctggc agctactggc cagctcggca 540 ctcaggagcc cgagtgatac tgctggtgct ctaccgggag cacctgaatc ctaatggtca 600 ccacttctta accaaggagg agctgctgca gaggtgtgct cagaagtccc ccagggtagc 660 ccctgggagt gctcgaccct ggccagccct ccgctccctc cttcacagga acctggtcct 720 caggacacac cagccagcca ggtactcatt gaccccagag ggcctggagc tggcccagaa 780 gttggccgag tcagaaggcc tgagcttgct gaatgtgggc atcgggccca aggagccccc 840 tggggaggag acagcagtgc caggagcagc ttcagcagag cttgccagtg aagcaggggt 900 ccagcagcag ccactggagc tgaggcctgg agagtacagg gtgctgttgt gtgtggacat 960 tggcgagacc cgggggggcg ggcacaggcc ggagctgctc cgagagctac agcggctgca 1020 cgtgacccac acggtgcgca agctgcacgt tggagatttt gtgtgggtgg cccaggagac 1080 caatcctaga gacccagcaa accctgggga gttggtactg gatcacattg tggagcgcaa 1140 gcgactggat gacctttgca gcagcatcat cgacggccgc ttccgggagc agaagttccg 1200 gctgaagcgc tgtggtctgg agcgccgggt atacctggtg gaagagcatg gttccgtcca 1260 caacctcagc cttcctgaga gcacactgct gcaggctgtc accaacactc aggtcattga 1320 tggctttttt gtgaagcgca cagcagacat taaggagtca gccgcctacc tggccctctt 1380 gacgcggggc ctgcagagac tctaccaggg ccacacccta cgcagccgcc cctggggaac 1440 ccctgggaac cctgaatcag gggccatgac ctctccaaac cctctctgct cactcctcac 1500 cttcagtgac ttcaacgcag gagccatcaa gaataaggcc cagtcggtgc gagaagtgtt 1560 tgcccggcag ctgatgcagg tgcgcggagt gagtggggag aaggcagcag ccctggtgga 1620 tcgatacagc acccctgcca gcctcctggc cgcctatgat gcctgtgcca cccccaagga 1680 acaagagaca ctgctgagca ccattaagtg tgggcgtcta cagaggaatc tggggcctgc 1740 tctgagcagg accttatccc agctctactg cagctacggc cccttgacct gagcttatgc 1800 cgtgaaacag cccccagccc ccgtctgtcc cccaacccag gctagccagc cttttaacaa 1860 catcttttgg ggtacaatta gaatctaagt gtttgcagcc atatgtgtca tgtagaagat 1920 gcctagccct ggggaccttg tgaaatacgc aggaaccagg gataccatct ggtccagtgg 1980 tttttaaaca aagctgctta gcacctggaa ttccctggtc agggagatgg agtcagtggg 2040 gcattgcagc ttggaatcta ttttatgtca ccagttggtc ctcatcaaat aaaatttcct 2100 taggagtgca gagggctcat tgggaaaata aaaataataa aaataaat 2148 <210> 827 <211> 1810 <212> DNA <213> Homo sapiens <400> 827 cccagagggc ctggagctgg cccagaagtt ggccgagtca gaaggcctga gcttgctgaa 60 tgtgggcatc gggcccaagg agccccctgg ggaggagaca gcagtgccag gagcagcttc 120 agcagagctt gccagtgaag caggggtcca gcagcagcca ctggagctga ggcctggaga 180 gtacagggtg ctgttgtgtg tggacattgg cgagacccgg gggggcgggc acaggccgga 240 gctgctccga gagctacagc ggctgcacgt gacccacacg gtgcgcaagc tgcacgttgg 300 agattttgtg tgggtggccc aggagaccaa tcctagagac ccagcaaacc ctggggagtt 360 ggtactggat cacattgtgg agcgcaagcg actggatgac ctttgcagca gcatcatcga 420 cggccgcttc cgggagcaga aggtaatttt gctggctttg ccaggcttcc ctgcctgctc 480 cgaagccccg ttttcagccc agagcaatcc aggggcactt ctggcagcct ccttgaggca 540 gagccctttg gaatccagcc acacccaccc tgtggctgct ccaggatcag acccccacag 600 gcccatccag gcgcacagta ggaagccagt tccggctgaa gcgctgtggt ctggagcgcc 660 gggtatacct ggtggaagag catggttccg tccacaacct cagccttcct gagagcacac 720 tgctgcaggc tgtcaccaac actcaggtca ttgatggctt ttttgtgaag cgcacagcag 780 acattaagga gtcagccgcc tacctggccc tcttgacgcg gggcctgcag agactctacc 840 aggtgagcag aggccccttt cccagtgtcg ggacagagcc cacaaggaat tcaccttgcc 900 tgggccctgt gcatccccaa aagaagcaag gtgggtgaga tccccatttc tcaggctggc 960 cccccaaggc tgaggactgg gcaggggctg gctggagttg ttccttcgag ctccagcctg 1020 gcctcagtcc cttcttccct cagggccaca ccctacgcag ccgcccctgg ggaacccctg 1080 ggaaccctga atcaggggcc atgacctctc caaaccctct ctgctcactc ctcaccttca 1140 gtgacttcaa cgcaggagcc atcaagaata aggcccagtc ggtgcgagaa gtgtttgccc 1200 ggcagctgat gcaggtgcgc ggagtgagtg gggagaaggc agcagccctg gtggatcgat 1260 acagcacccc tgccagcctc ctggccgcct atgatgcctg tgccaccccc aaggaacaag 1320 agacactgct gagcaccatt aagtgtgggc gtctacagag gaatctgggg cctgctctga 1380 gcaggacctt atcccagctc tactgcagct acggcccctt gacctgagct tatgccgtga 1440 aacagccccc agcccccgtc tgtcccccaa cccaggctag ccagcctttt aacaacatct 1500 tttggggtac aattagaatc taagtgtttg cagccatatg tgtcatgtag aagatgccta 1560 gccctgggga ccttgtgaaa tacgcaggaa ccagggatac catctggtcc agtggttttt 1620 aaacaaagct gcttagcacc tggaattccc tggtcaggga gatggagtca gtggggcatt 1680 gcagcttgga atctatttta tgtcaccagt tggtcctcat caaataaaat ttccttagga 1740 gtgcagaggg ctcattggga aaataaaaat aataaaaata aataaaactt cctaaaaaaa 1800 aaaaaaaaaa 1810 <210> 828 <211> 1997 <212> DNA <213> Homo sapiens <400> 828 cgttcgctgg ctgaccgagt ggcgggacga ggcgacccgc agcaggcacc gcacgcgctt 60 cgtatttcag aaggcgctgc gttccctccg acggtaccca ctgccgctgc gcagcgggaa 120 ggaagctaag atcctacagc acttcggaga cgggctctgc cggatgctgg acgagcggct 180 gcagcggcac cgaacatcgg gcggtgacca tgccccggac tcaccatctg gagagaacag 240 tccagccccg caggggcgac ttgcggaagt ccaggactct tccatgccag ttcctgccca 300 gcccaaagcg ggaggctctg gcagctactg gccagctcgg cactcaggag cccgagtgat 360 actgctggtg ctctaccggg agcacctgaa tcctaatggt caccacttct taaccaagga 420 ggagctgctg cagaggtgtg ctcagaagtc ccccagggta gcccctggga gtgccccacc 480 ctggccagcc ctccgctccc tccttcacag gaacctggtc ctcaggacac accagccagc 540 caggtactca ttgaccccag agggcctgga gctggcccag aagttggccg agtcagaagg 600 cctgagcttg ctgaatgtgg gcatcgggcc caaggagccc cctggggagg agacagcagt 660 gccaggagca gcttcagcag agcttgccag tgaagcaggg gtccagcagc agccactgga 720 gctgaggcct ggagagtaca gggtgctgtt gtgtgtggac attggcgaga cccggggggg 780 cgggcacagg ccggagctgc tccgagagct acagcggctg cacgtgaccc acacggtgcg 840 caagctgcac gttggagatt ttgtgtgggt ggctcaggag accaatccta gagacccagc 900 aaaccctggg gagttggtac tggatcacat tgtggagcgc aagcgactgg atgacctttg 960 cagcagcatc atcgacggcc gcttccggga gcagaagttc cgactgaagc gctgtggtct 1020 ggagcgccgg gtatacctgg tggaagagca tggttccgtc cacaacctca gccttcctga 1080 gagcacactg ctgcaggctg tcaccaacac tcaggtcatt gatggctttt ttgtgaagcg 1140 cacagcagac attaaggagt cagccgccta cctggccctc ttgactcggg gcctgcagag 1200 actctaccag ggccacaccc tacgcagccg cccctgggga acccctggga accctgaatc 1260 aggggccatg acctctccaa accctctctg ctcactcctc accttcagtg acttcaacgc 1320 aggagccatc aagaataagg cccagtcggt gcgagaagtg tttgcccggc agctgatgca 1380 ggtgcgcgga gtgagtgggg agaaggcagc agccctggtg gatcgataca gcacccctgc 1440 cagcctcctg gccgcctatg atgcctgtgc cacccccaag gaacaagaga cactgctgag 1500 caccattaag tgtgggcgtc tacagaggaa tctggggcct gctctgagca ggaccttatc 1560 ccagctctac tgcagctacg gccccttgac ctgagcttat gccgtgaaac agcccccagc 1620 ccccgtctgt cccccaaccc aggctagcca gccttttaac aacatctttt ggggtacaat 1680 tagaatctaa gtgtttgcag ccatatgtgt catgtagaag atgcctagcc ctggggacct 1740 tgtgaaatac gcaggaacca gggataccat ctggtccagt ggtttttaaa caaagctgct 1800 tagcacctgg aattccctgg tcagggagat ggagtcagtg gggcattgca gcttggaatc 1860 tattttatgt caccagttgg tcctcatcaa ataaaatttc cttaggagtg cagagggctc 1920 attgggaaaa taaaaataat aaaaataaat aaaacttcct aaaagaaaag attgaaaacc 1980 aaaaaaaaaa aaaaaaa 1997 <210> 829 <211> 2343 <212> DNA <213> Homo sapiens <400> 829 gtctcaaagg ctggctggag tggagccaaa ggaaaagatc gttagagaca gcgcccctga 60 ccaaccactt agagcagcgc aggggtggga gggcggccgc aggctctcct ctcgttagtg 120 ccccctgtgt ttggggcccc gtgatctcaa cggtcctgcc ctcggtctcc ctcttccccc 180 gccccgccct gggccaggtg ttcgaatccc gactccagaa ctggcggcgt cccagtcccg 240 cgggcgtgga gcgccggagg acccgccctc gggctcatgg cggccccggt ccgcctgggc 300 cggaagcgcc cgctgcctgc ctgtcccaac ccgctcttcg ttcgctggct gaccgagtgg 360 cgggacgagg cgacccgcag caggcaccgc acgcgcttcg tatttcagaa ggcgctgcgt 420 tccctccgac ggtacccact gccgctgcgc agcgggaagg aagctaagat cctacagcac 480 ttcggagacg ggctctgccg gatgctggac gagcggctgc agcggcaccg aacatcgggc 540 ggtgaccatg ccccggactc accatctgga gagaacagtc cagccccgca ggggcgactt 600 gcggaagtcc aggactcttc catgccagtt cctgcccagc ccaaagcggg aggctctggc 660 agctactggc cagctcggca ctcaggagcc cgagtgatac tgctggtgct ctaccgggag 720 cacctgaatc ctaatggtca ccacttctta accaaggagg agctgctgca gaggtgtgct 780 cagaagtccc ccagggtagc ccctgggagt gccccaccct ggccagccct ccgctccctc 840 cttcacagga acctggtcct caggacacac cagccagcca ggtactcatt gaccccagag 900 ggcctggagc tggcccagaa gttggccgag tcagaaggcc tgagcttgct gaatgtgggc 960 atcgggccca aggagccccc tggggaggag acagcagtgc caggagcagc ttcagcagag 1020 cttgccagtg aagcaggggt ccagcagcag ccactggagc tgaggcctgg agagtacagg 1080 gtgctgttgt gtgtggacat tggcgagacc cgggggggcg ggcacaggcc ggagctgctc 1140 cgagagctac agcggctgca cgtgacccac acggtgcgca agctgcacgt tggagatttt 1200 gtgtgggtgg ctcaggagac caatcctaga gacccagcaa accctgggga gttggtactg 1260 gatcacattg tggagcgcaa gcgactggat gacctttgca gcagcatcat cgacggccgc 1320 ttccgggagc agaagttccg actgaagcgc tgtggtctgg agcgccgggt atacctggtg 1380 gaagagcatg gttccgtcca caacctcagc cttcctgaga gcacactgct gcaggctgtc 1440 accaacactc aggtcattga tggctttttt gtgaagcgca cagcagacat taaggagtca 1500 gccgcctacc tggccctctt gactcggggc ctgcagagac tctaccaggg ccacacccta 1560 cgcagccgcc cctggggaac ccctgggaac cctgaatcag gggccatgac ctctccaaac 1620 cctctctgct cactcctcac cttcagtgac ttcaacgcag gagccatcaa gaataaggcc 1680 cagtcggtgc gagaagtgtt tgcccggcag ctgatgcagg tgcgcggagt gagtggggag 1740 aaggcagcag ccctggtgga tcgatacagc acccctgcca gcctcctggc cgcctatgat 1800 gcctgtgcca cccccaagga acaagagaca ctgctgagca ccattaagtg tgggcgtcta 1860 cagaggaatc tggggcctgc tctgagcagg accttatccc agctctactg cagctacggc 1920 cccttgacct gagcttatgc cgtgaaacag cccccagccc ccgtctgtcc cccaacccag 1980 gctagccagc cttttaacaa catcttttgg ggtacaatta gaatctaagt gtttgcagcc 2040 atatgtgtca tgtagaagat gcctagccct ggggaccttg tgaaatacgc aggaaccagg 2100 gataccatct ggtccagtgg tttttaaaca aagctgctta gcacctggaa ttccctggtc 2160 agggagatgg agtcagtggg gcattgcagc ttggaatcta ttttatgtca ccagttggtc 2220 ctcatcaaat aaaatttcct taggagtgca gagggctcat tgggaaaata aaaataataa 2280 aaataaataa aacttcctaa aagaaaagat tgaaacccaa aaaaaaaaaa aaaaaaaaaa 2340 aaa 2343 <210> 830 <211> 2343 <212> DNA <213> Homo sapiens <400> 830 gtctcaaagg ctggctggag tggagccaaa ggaaaagatc gttagagaca gcgcccctga 60 ccaaccactt agagcagcgc aggggtggga gggcggccgc aggctctcct ctcgttagtg 120 ccccctgtgt ttggggcccc gtgatctcaa cggtcctgcc ctcggtctcc ctcttccccc 180 gccccgccct gggccaggtg ttcgaatccc gactccagaa ctggcggcgt cccagtcccg 240 cgggcgtgga gcgccggagg acccgccctc gggctcatgg cggccccggt ccgcctgggc 300 cggaagcgcc cgctgcctgc ctgtcccaac ccgctcttcg ttcgctggct gaccgagtgg 360 cgggacgagg cgacccgcag caggcaccgc acgcgcttcg tatttcagaa ggcgctgcgt 420 tccctccgac ggtacccact gccgctgcgc agcgggaagg aagctaagat cctacagcac 480 ttcggagacg ggctctgccg gatgctggac gagcggctgc agcggcaccg aacatcgggc 540 ggtgaccatg ccccggactc accatctgga gagaacagtc cagccccgca ggggcgactt 600 gcggaagtcc aggactcttc catgccagtt cctgcccagc ccaaagcggg aggctctggc 660 agctactggc cagctcggca ctcaggagcc cgagtgatac tgctggtgct ctaccgggag 720 cacctgaatc ctaatggtca ccacttctta accaaggagg agctgctgca gaggtgtgct 780 cagaagtccc ccagggtagc ccctgggagt gccccaccct ggccagccct ccgctccctc 840 cttcacagga acctggtcct caggacacac cagccagcca ggtactcatt gaccccagag 900 ggcctggagc tggcccagaa gttggccgag tcagaaggcc tgagcttgct gaatgtgggc 960 atcgggccca aggagccccc tggggaggag acagcagtgc caggagcagc ttcagcagag 1020 cttgccagtg aagcaggggt ccagcagcag ccactggagc tgaggcctgg agagtacagg 1080 gtgctgttgt gtgtggacat tggcgagacc cgggggggcg ggcacaggcc ggagctgctc 1140 cgagagctac agcggctgca cgtgacccac acggtgcgca agctgcacgt tggagatttt 1200 gtgtgggtgg ctcaggagac caatcctaga gacccagcaa accctgggga gttggtactg 1260 gatcacattg tggagcgcaa gcgactggat gacctttgca gcagcatcat cgacggccgc 1320 ttccgggagc agaagttccg actgaagcgc tgtggtctgg agcgccgggt atacctggtg 1380 gaagagcatg gttccgtcca caacctcagc cttcctgaga gcacactgct gcaggctgtc 1440 accaacactc aggtcattga tggctttttt gtgaagcgca cagcagacat taaggagtca 1500 gccgcctacc tggccctctt gactcggggc ctgcagagac tctaccaggg ccacacccta 1560 cgcagccgcc cctggggaac ccctgggaac cctgaatcag gggccatgac ctctccaaac 1620 cctctctgct cactcctcac cttcagtgac ttcaacgcag gagccatcaa gaataaggcc 1680 cagtcggtgc gagaagtgtt tgcccggcag ctgatgcagg tgcgcggagt gagtggggag 1740 aaggcagcag ccctggtgga tcgatacagc acccctgcca gcctcctggc cgcctatgat 1800 gcctgtgcca cccccaagga acaagagaca ctgctgagca ccattaagtg tgggcgtcta 1860 cagaggaatc tggggcctgc tctgagcagg accttatccc agctctactg cagctacggc 1920 cccttgacct gagcttatgc cgtgaaacag cccccagccc ccgtctgtcc cccaacccag 1980 gctagccagc cttttaacaa catcttttgg ggtacaatta gaatctaagt gtttgcagcc 2040 atatgtgtca tgtagaagat gcctagccct ggggaccttg tgaaatacgc aggaaccagg 2100 gataccatct ggtccagtgg tttttaaaca aagctgctta gcacctggaa ttccctggtc 2160 agggagatgg agtcagtggg gcattgcagc ttggaatcta ttttatgtca ccagttggtc 2220 ctcatcaaat aaaatttcct taggagtgca gagggctcat tgggaaaata aaaataataa 2280 aaataaataa aacttcctaa aagaaaagat tgaaacccaa aaaaaaaaaa aaaaaaaaaa 2340 aaa 2343 <210> 831 <211> 1656 <212> DNA <213> Homo sapiens <400> 831 atggcggccc cggtccgcct gggccggaag cgcccgctgc ctgcctgtcc caacccgctc 60 ttcgttcgct ggctgaccga gtggcgggac gaggcgaccc gcagcaggca ccgcacgcgc 120 ttcgtatttc agaaggcgct gcgttccctc cgacggtacc cactgccgct gcgcagcggg 180 aaggaagcta agatcctaca gcacttcgga gacgggctct gccggatgct ggacgagcgg 240 ctgcagcggc accgaacatc gggcggtgac catgccccgg actcaccatc tggagagaac 300 agtccagccc cgcaggggcg acttgcggaa gtccaggact cttccatgcc agttcctgcc 360 cagcccaaag cgggaggctc tggcagctac tggccagctc ggcactcagg agcccgagtg 420 atactgctgg tgctctaccg ggagcacctg aatcctaatg gtcaccactt cttaaccaag 480 gaggagctgc tgcagaggtg tgctcagaag tcccccaggg tagcccctgg gagtgcccca 540 ccctggccag ccctccgctc cctccttcac aggaacctgg tcctcaggac acaccagcca 600 gccaggtact cattgacccc agagggcctg gagctggccc agaagttggc cgagtcagaa 660 ggcctgagct tgctgaatgt gggcatcggg cccaaggagc cccctgggga ggagacagca 720 gtgccaggag cagcttcagc agagcttgcc agtgaagcag gggtccagca gcagccactg 780 gagctgaggc ctggagagta cagggtgctg ttgtgtgtgg acattggcga gacccggggg 840 ggcgggcaca ggccggagct gctccgagag ctacagcggc tgcacgtgac ccacacggtg 900 cgcaagctgc acgttggaga ttttgtgtgg gtggctcagg agaccaatcc tagagaccca 960 gcaaaccctg gggagttggt actggatcac attgtggagc gcaagcgact ggatgacctt 1020 tgcagcagca tcatcgacgg ccgcttccgg gagcagaagt tccgactgaa gcgctgtggt 1080 ctggagcgcc gggtatacct ggtggaagag catggttccg tccacaacct cagccttcct 1140 gagagcacac tgctgcaggc tgtcaccaac actcaggtca ttgatggctt ttttgtgaag 1200 cgcacagcag acattaagga gtcagccgcc tacctggccc tcttgactcg gggcctgcag 1260 agactctacc agggccacac cctacgcagc cgcccctggg gaacccctgg gaaccctgaa 1320 tcaggggcca tgacctctcc aaaccctctc tgctcactcc tcaccttcag tgacttcaac 1380 gcaggagcca tcaagaataa ggcccagtcg gtgcgagaag tgtttgcccg gcagctgatg 1440 caggtgcgcg gagtgagtgg ggagaaggca gcagccctgg tggatcgata cagcacccct 1500 gccagcctcc tggccgccta tgatgcctgt gccaccccca aggaacaaga gacactgctg 1560 agcaccatta agtgtgggcg tctacagagg aatctggggc ctgctctgag caggacctta 1620 tcccagctct actgcagcta cggccccttg acctga 1656 <210> 832 <211> 3576 <212> DNA <213> Homo sapiens <400> 832 aagcgcccgc tgcctgcctg tcccaacccg ctcttcgttc gctggctgac cgagtggcgg 60 gacgaggcga cccgcagcag gcaccgcacg cgcttcgtat ttcagaaggt gggtcctggc 120 gtggcccgat gggaaaagct gctggccagg tcaggcctgc cccggactca ccatctggag 180 agaacagtcc agccccgcag gggcgacttg cggaagtcca ggactcttcc atgccagtga 240 ggaaggggca aggggagtgg aaggcagtgg gagtgcggga gtatgatttt ctggcttggg 300 ggatttggca agcctgagtc caaatctcac cagtgatgcc tggccttgag caaatgactt 360 atcctctttt cgacttagta ttttaacctg tgaatagaaa tattggtaac agccaatgag 420 agaattccat gatcaagcta cttaaggatc ccagctcagt tagttacggg gtcaccatta 480 ttgagttttc ctgtctaatt acacctgtcc tgcagcgcat ggtagaagtg aggccaggct 540 gggcagacac ccccacccac tgccccgaaa ctgcctgctg ttttatccca gatttgcagc 600 ggatcatccc atcacctggc ccattttaca gagaaggaaa ctgagagaca actgagtgac 660 ttacccaggg ccacaaagcc tgctggggac ttattcaaag atgactggct ggctttcatg 720 ttcagaactc ctctgtacct ttcaggttcc tgcccagccc aaagcgggag gctctggcag 780 ctactggcca gctcggcact caggagcccg agtgatactg ctggtgctct accgggagca 840 cctgaatcct aatggtcacc acttcttaac caaggaggag ctgctgcaga ggtgtgctca 900 gaagtccccc agggtagccc ctgggagtgc cccaccctgg ccagccctcc gctccctcct 960 tcacaggaac ctggtcctca ggacacacca gccagccagg tactcattga ccccagaggg 1020 cctggagctg gcccagaagt tggccgagtc agaaggcctg agcttgctga atgtgggcat 1080 cgggcccaag gagccccctg gggaggagac agcagtgcca ggagcagctt cagcagagct 1140 tgccagtgaa gcaggggtcc agcagcagcc actggagctg aggcctggag agtacagggt 1200 gctgttgtgt gtggacattg gcgagacccg ggggtgagtg aggtggggag aaacgaggga 1260 gatgatcaga ggaggctggg gggtaggcac tgccctgctc tgatctaggc ttccctcctt 1320 gccactccag gggcgggcac aggccggagc tgctccgaga gctacagcgg ctgcacgtga 1380 cccacacggt gcgcaagctg cacgttggag attttgtgtg ggtggctcag gagaccaatc 1440 ctagagaccc aggtgaaggg ccgtggacag gctggcacca ggggcagggc ctggtgggta 1500 ggggatcgca agctaacggc tggcttgtca gcagcaaacc ctggggagtt ggtactggat 1560 cacattgtgg agcgcaagcg actggatgac ctttgcagca gcatcatcga cggccgcttc 1620 cgggagcaga aggtaatttt gctggctttg ccaggcttcc ctgcctgctc cgaagccccg 1680 ttttcagccc agagcaatcc aggggcactt ctggcagcct ccttgaggca gagccctttg 1740 gaatccagcc acacccaccc tgtggctgct ccaggatcag acccccacag gcccatccag 1800 gcgcacagta ggaagccagg tacctgcatt cttgggctga ggtcaggagc attttaaaga 1860 cctcttgggt acccagcccc tgcagtcttg gataaacaag gcataaacct ccaggagtgg 1920 aaatacagag gctgtacctt ggtacttgct gctgggtgga cccctagtca cagaggccat 1980 gtgccggccc aggggaggct tgaaggatgg gcagtgttga gagatggaga aaaggctttc 2040 tagacaagag tgtcagcatg agcaaagctg cggaggcccc tgtgaggcag gtggagaggc 2100 tagggaggat gcagagtcta actggtggga acagggtcac agcaccattt tgagtgtgac 2160 atcatggatg cccaggcatg tggtcatcca gcctgaccct ccctgtccac tctgtacact 2220 tccctagttc cgactgaagc gctgtggtct ggagcgccgg gtatacctgg tggaagagca 2280 tggttccgtc cacaacctca gccttcctga gagcacactg ctgcaggctg tcaccaacac 2340 tcaggtcatt gatggctttt ttgtgaagcg cacagcagac attaaggagt cagccgccta 2400 cctggccctc ttgactcggg gcctgcagag actctaccag gtgagcagag gcccctttcc 2460 cagtgtcggg acagagccca caaggaattc accttgcctg ggccctgtgc atccccaaaa 2520 gaagcaaggt gggtgagatc cccatttctc aggctggccc cccaaggctg aggactgggc 2580 aggggctggc tggagttgtt ccttcgagct ccagcctggc ctcagtccct tcttccctca 2640 gggccacacc ctacgcagcc gcccctgggg aacccctggg aaccctgaat caggggccat 2700 gacctctcca aaccctctct gctcactcct caccttcagt gacttcaacg caggagccat 2760 caagaataag gtactgtctc tgcctagctt ctcagacatg gcctggccca gacccccact 2820 gatccagccc tttcccgaac ccaggcccag tcggtgcgag aagtgtttgc ccggcagctg 2880 atgcaggtgc gcggagtgag tggggagaag gcagcagccc tggtggatcg atacagcacc 2940 cctgccagcc tcctggccgc ctatgatgcc tgtgccaccc ccaaggaaca agagacactg 3000 ctgagcacca ttaagtgtgg gcgtctacag aggtgagggc aagagacgga acctggaggg 3060 agtggcaggg actggggctg ccctaggccc agggcgtgac cctcgctgcc tctcttcctg 3120 caggaatctg gggcctgctc tgagcaggac cttatcccag ctctactgca gctacggccc 3180 cttgacctga gcttatgccg tgaaacagcc cccagccccc gtctgtcccc caacccaggc 3240 tagccagcct tttaacaaca tcttttgggg tacaattaga atctaagtgt ttgcagccat 3300 atgtgtcatg tagaagatgc ctagccctgg ggaccttgtg aaatacgcag gaaccaggga 3360 taccatctgg tccagtggtt tttaaacaaa gctgcttagc acctggaatt ccctggtcag 3420 ggagatggag tcagtggggc attgcagctt ggaatctatt ttatgtcacc agttggtcct 3480 catcaaataa aatttcctta ggattgcaga gggctcattg ggaaaataaa aataataaaa 3540 ataaataaaa cttcctaaaa gaaaagattg aaaacc 3576 <210> 833 <211> 4107 <212> DNA <213> Homo sapiens <400> 833 gtcgagcggg agcagaggag gcgagggagg agggccagag aggcagttgg aagatggcgg 60 acgaggcggc cctcgccctt cagcccggcg gctccccctc ggcggcgggg gccgacaggg 120 aggccgcgtc gtcccccgcc ggggagccgc tccgcaagag gccgcggaga gatggtcccg 180 gcctcgagcg gagcccgggc gagcccggtg gggcggcccc agagcgtgag gtgccggcgg 240 cggccagggg ctgcccgggt gcggcggcgg cggcgctgtg gcgggaggcg gaggcagagg 300 cggcggcggc aggcggggag caagaggccc aggcgactgc ggcggctggg gaaggagaca 360 atgggccggg cctgcagggc ccatctcggg agccaccgct ggccgacaac ttgtacgacg 420 aagacgacga cgacgagggc gaggaggagg aagaggcggc ggcggcggcg attgggtacc 480 gagataacct tctgttcggt gatgaaatta tcactaatgg ttttcattcc tgtgaaagtg 540 atgaggagga tagagcctca catgcaagct ctagtgactg gactccaagg ccacggatag 600 gtccatatac ttttgttcag caacatctta tgattggcac agatcctcga acaattctta 660 aagatttatt gccggaaaca atacctccac ctgagttgga tgatatgaca ctgtggcaga 720 ttgttattaa tatcctttca gaaccaccaa aaaggaaaaa aagaaaagat attaatacaa 780 ttgaagatgc tgtgaaatta ctgcaagagt gcaaaaaaat tatagttcta actggagctg 840 gggtgtctgt ttcatgtgga atacctgact tcaggtcaag ggatggtatt tatgctcgcc 900 ttgctgtaga cttcccagat cttccagatc ctcaagcgat gtttgatatt gaatatttca 960 gaaaagatcc aagaccattc ttcaagtttg caaaggaaat atatcctgga caattccagc 1020 catctctctg tcacaaattc atagccttgt cagataagga aggaaaacta cttcgcaact 1080 atacccagaa catagacacg ctggaacagg ttgcgggaat ccaaaggata attcagtgtc 1140 atggttcctt tgcaacagca tcttgcctga tttgtaaata caaagttgac tgtgaagctg 1200 tacgaggaga tatttttaat caggtagttc ctcgatgtcc taggtgccca gctgatgaac 1260 cgcttgctat catgaaacca gagattgtgt tttttggtga aaatttacca gaacagtttc 1320 atagagccat gaagtatgac aaagatgaag ttgacctcct cattgttatt gggtcttccc 1380 tcaaagtaag accagtagca ctaattccaa gttccatacc ccatgaagtg cctcagatat 1440 taattaatag agaacctttg cctcatctgc attttgatgt agagcttctt ggagactgtg 1500 atgtcataat taatgaattg tgtcataggt taggtggtga atatgccaaa ctttgctgta 1560 accctgtaaa gctttcagaa attactgaaa aacctccacg aacacaaaaa gaattggctt 1620 atttgtcaga gttgccaccc acacctcttc atgtttcaga agactcaagt tcaccagaaa 1680 gaacttcacc accagattct tcagtgattg tcacactttt agaccaagca gctaagagta 1740 atgatgattt agatgtgtct gaatcaaaag gttgtatgga agaaaaacca caggaagtac 1800 aaacttctag gaatgttgaa agtattgctg aacagatgga aaatccggat ttgaagaatg 1860 ttggttctag tactggggag aaaaatgaaa gaacttcagt ggctggaaca gtgagaaaat 1920 gctggcctaa tagagtggca aaggagcaga ttagtaggcg gcttgatggt aatcagtatc 1980 tgtttttgcc accaaatcgt tacattttcc atggcgctga ggtatattca gactctgaag 2040 atgacgtctt atcctctagt tcttgtggca gtaacagtga tagtgggaca tgccagagtc 2100 caagtttaga agaacccatg gaggatgaaa gtgaaattga agaattctac aatggcttag 2160 aagatgagcc tgatgttcca gagagagctg gaggagctgg atttgggact gatggagatg 2220 atcaagaggc aattaatgaa gctatatctg tgaaacagga agtaacagac atgaactatc 2280 catcaaacaa atcatagtgt aataattgtg caggtacagg aattgttcca ccagcattag 2340 gaactttagc atgtcaaaat gaatgtttac ttgtgaactc gatagagcaa ggaaaccaga 2400 aaggtgtaat atttataggt tggtaaaata gattgttttt catggataat ttttaacttc 2460 attatttctg tacttgtaca aactcaacac taactttttt ttttttaaaa aaaaaaaggt 2520 actaagtatc ttcaatcagc tgttggtcaa gactaacttt cttttaaagg ttcatttgta 2580 tgataaattc atatgtgtat atataatttt ttttgttttg tctagtgagt ttcaacattt 2640 ttaaagtttt caaaaagcca tcggaatgtt aaattaatgt aaagggacag ctaatctaga 2700 ccaaagaatg gtattttcac ttttctttgt aacattgaat ggtttgaagt actcaaaatc 2760 tgttacgcta aacttttgat tctttaacac aattattttt aaacactggc attttccaaa 2820 actgtggcag ctaacttttt aaaatctcaa atgacatgca gtgtgagtag aaggaagtca 2880 acaatatgtg gggagagcac tcggttgtct ttacttttaa aagtaatact tggtgctaag 2940 aatttcagga ttattgtatt tacgttcaaa tgaagatggc ttttgtactt cctgtggaca 3000 tgtagtaatg tctatattgg ctcataaaac taacctgaaa aacaaataaa tgctttggaa 3060 atgtttcagt tgctttagaa acattagtgc ctgcctggat ccccttagtt ttgaaatatt 3120 tgccattgtt gtttaaatac ctatcactgt ggtagagctt gcattgatct tttccacaag 3180 tattaaactg ccaaaatgtg aatatgcaaa gcctttctga atctataata atggtacttc 3240 tactggggag agtgtaatat tttggactgc tgttttccat taatgaggag agcaacaggc 3300 ccctgattat acagttccaa agtaataaga tgttaattgt aattcagcca gaaagtacat 3360 gtctcccatt gggaggattt ggtgttaaat accaaactgc tagccctagt attatggaga 3420 tgaacatgat gatgtaactt gtaatagcag aatagttaat gaatgaaact agttcttata 3480 atttatcttt atttaaaagc ttagcctgcc ttaaaactag agatcaactt tctcagctgc 3540 aaaagcttct agtctttcaa gaagttcata ctttatgaaa ttgcacagta agcatttatt 3600 tttcagacca tttttgaaca tcactcctaa attaataaag tattcctctg ttgctttagt 3660 atttattaca ataaaaaggg tttgaaatat agctgttctt tatgcataaa acacccagct 3720 aggaccatta ctgccagaga aaaaaatcgt attgaatggc catttcccta cttataagat 3780 gtctcaatct gaatttattt ggctacacta aagaatgcag tatatttagt tttccatttg 3840 catgatgttt gtgtgctata gatgatattt taaattgaaa agtttgtttt aaattatttt 3900 tacagtgaag actgttttca gctcttttta tattgtacat agtcttttat gtaatttact 3960 ggcatatgtt ttgtagactg tttaatgact ggatatcttc cttcaacttt tgaaatacaa 4020 aaccagtgtt ttttacttgt acactgtttt aaagtctatt aaaattgtca tttgactttt 4080 ttctgttaaa aaaaaaaaaa aaaaaaa 4107 <210> 834 <211> 3345 <212> DNA <213> Homo sapiens <400> 834 cacttactaa atggaattta ataaaaacac tgtcaaaagt tgggaggacc aaaattgata 60 ctttttctct gatctttttg ccatgtgtat atctgaattc tttgttttta aagaagaaac 120 agcattgaag cattatttgg ggggaaaaac acacacacaa aatccagcaa ctcagcattc 180 atgagcaact ctatactata ccagtatgtg cctgtgcagt ggaaggaaaa caattttgga 240 aatatatcct ggacaattcc agccatctct ctgtcacaaa ttcatagcct tgtcagataa 300 ggaaggaaaa ctacttcgca actataccca gaacatagac acgctggaac aggttgcggg 360 aatccaaagg ataattcagt gtcatggttc ctttgcaaca gcatcttgcc tgatttgtaa 420 atacaaagtt gactgtgaag ctgtacgagg agatattttt aatcaggtag ttcctcgatg 480 tcctaggtgc ccagctgatg aaccgcttac tatcatgaaa ccagagattg tgttttttgg 540 tgaaaattta ccagaacagt ttcatagagc catgaagtat gacaaagatg aagttgacct 600 cctcattgtt attgggtctt ccctcaaagt aagaccagta gcactaattc caagttccat 660 accccatgaa gtgcctcaga tattaattaa tagagaacct ttgcctcatc tgcattttga 720 tgtagagctt cttggagact gtgatgtcat aattaatgaa ttgtgtcata ggttaggtgg 780 tgaatatgcc aaactttgct gtaaccctgt aaagctttca gaaattactg aaaaacctcc 840 acgaacacaa aaagaattgg cttatttgtc agagttgcca cccacacctc ttcatgtttc 900 agaagactca agttcaccag aaagaacttc accaccagat tcttcagtga ttgtcacact 960 tttagaccaa gcagctaaga gtaatgatga tttagatgtg tctgaatcaa aaggttgtat 1020 ggaagaaaaa ccacaggaag tacaaacttc taggaatgtt gaaagtattg ctgaacagat 1080 ggaaaatccg gatttgaaga atgttggttc tagtactggg gagaaaaatg aaagaacttc 1140 agtggctgga acagtgagaa aatgctggcc taatagagtg gcaaaggagc agattagtag 1200 gcggcttgat ggtaatcagt atctgttttt gccaccaaat cgttacattt tccatggcgc 1260 tgaggtatat tcagactctg aagatgacgt cttatcctct agttcttgtg gcagtaacag 1320 tgatagtggg acatgccaga gtccaagttt agaagaaccc atggaggatg aaagtgaaat 1380 tgaagaattc tacaatggct tagaagatga gcctgatgtt ccagagagag ctggaggagc 1440 tggatttggg actgatggag atgatcaaga ggcaattaat gaagctatat ctgtgaaaca 1500 ggaagtaaca gacatgaact atccatcaaa caaatcatag tgtaataatt gtgcaggtac 1560 aggaattgtt ccaccagcat taggaacttt agcatgtcaa aatgaatgtt tacttgtgaa 1620 ctcgatagag caaggaaacc agaaaggtgt aatatttata ggttggtaaa atagattgtt 1680 tttcatggat aatttttaac ttcattattt ctgtacttgt acaaactcaa cactaacttt 1740 tttttttttt taaaaaaaaa aaggtactaa gtatcttcaa tcagctgttg gtcaagacta 1800 acttttaaag gttcatttgt atgataaatt catatgtgta tatataattt tttttgtttt 1860 gtctagtgag tttcaacatt tttaaagttt tcaaaaagcc atcggaatgt taaattaatg 1920 taaagggaac agctaatcta gaccaaagaa tggtattttc acttttcttt gtaacattga 1980 atggtttgaa gtactcaaaa tctgttacgc taaacttttg attctttaac acaattattt 2040 ttaaacactg gcattttcca aaactgtggc agctaacttt ttaaaatctc aaatgacatg 2100 cagtgtgagt agaaggaagt caacaatatg tggggagagc actcggttgt ctttactttt 2160 aaaagtaata cttggtgcta agaatttcag gattattgta tttacgttca aatgaagatg 2220 gcttttgtac ttcctgtgga catgtagtaa tgtctatatt ggctcataaa actaacctga 2280 aaaacaaata aatgctttgg aaatgtttca gttgctttag aaacattagt gcctgcctgg 2340 atccccttag ttttgaaata tttgccattg ttgtttaaat acctatcact gtggtagagc 2400 ttgcattgat cttttccaca agtattaaac tgccaaaatg tgaatatgca aagcctttct 2460 gaatctataa taatggtact tctactgggg agagtgtaat attttggact gctgttttcc 2520 attaatgagg agagcaacag gcccctgatt atacagttcc aaagtaataa gatgttaatt 2580 gtaattcagc cagaaagtac atgtctccca ttgggaggat ttggtgttaa ataccaaact 2640 gctagcccta gtattatgga gatgaacatg atgatgtaac ttgtaatagc agaatagtta 2700 atgaatgaaa ctagttctta taatttatct ttatttaaaa gcttagcctg ccttaaaact 2760 agagatcaac tttctcagct gcaaaagctt ctagtctttc aagaagttca tactttatga 2820 aattgcacag taagcattta tttttcagac catttttgaa catcactcct aaattaataa 2880 agtattcctc tgttgcttta gtatttatta caataaaaag ggtttgaaat atagctgttc 2940 tttatgcata aaacacccag ctaggaccat tactgccaga gaaaaaaatc gtattgaatg 3000 gccatttccc tacttataag atgtctcaat ctgaatttat ttggctacac taaagaatgc 3060 agtatattta gttttccatt tgcatgatgt ttgtgtgcta tagatgatat tttaaattga 3120 aaagtttgtt ttaaattatt tttacagtga agactgtttt cagctctttt tatattgtac 3180 atagtctttt atgtaattta ctggcatatg ttttgtagac tgtttaatga ctggatatct 3240 tccttcaact tttgaaatac aaaaccagtg ttttttactt gtacactgtt ttaaagtcta 3300 ttaaaattgt catttgactt ttttctgtca aaaaaaaaaa aaaca 3345 <210> 835 <211> 4086 <212> DNA <213> Homo sapiens <400> 835 gtcgagcggg agcagaggag gcgagggagg agggccagag aggcagttgg aagatggcgg 60 acgaggcggc cctcgccctt cagcccggcg gctccccctc ggcggcgggg gccgacaggg 120 aggccgcgtc gtcccccgcc ggggagccgc tccgcaagag gccgcggaga gatggtcccg 180 gcctcgagcg gagcccgggc gagcccggtg gggcggcccc agagcgtgag gtgccggcgg 240 cggccagggg ctgcccgggt gcggcggcgg cggcgctgtg gcgggaggcg gaggcagagg 300 cggcggcggc aggcggggag caagaggccc aggcgactgc ggcggctggg gaaggagaca 360 atgggccggg cctgcagggc ccatctcggg agccaccgct ggccgacaac ttgtacgacg 420 aagacgacga cgacgagggc gaggaggagg aagaggcggc ggcggcggcg attgggtacc 480 gagataacct tctgttcggt gatgaaatta tcactaatgg ttttcattcc tgtgaaagtg 540 atgaggagga tagagcctca catgcaagct ctagtgactg gactccaagg ccacggatag 600 gtccatatac ttttgttcag caacatctta tgattggcac agatcctcga acaattctta 660 aagatttatt gccggaaaca atacctccac ctgagttgga tgatatgaca ctgtggcaga 720 ttgttattaa tatcctttca gaaccaccaa aaaggaaaaa aagaaaagat attaatacaa 780 ttgaagatgc tgtgaaatta ctgcaagagt gcaaaaaaat tatagttcta actggagctg 840 gggtgtctgt ttcatgtgga atacctgact tcaggtcaag ggatggtatt tatgctcgcc 900 ttgctgtaga cttcccagat cttccagatc ctcaagcgat gtttgatatt gaatatttca 960 gaaaagatcc aagaccattc ttcaagtttg caaaggaaat atatcctgga caattccagc 1020 catctctctg tcacaaattc atagccttgt cagataagga aggaaaacta cttcgcaact 1080 atacccagaa catagacacg ctggaacagg ttgcgggaat ccaaaggata attcagtgtc 1140 atggttcctt tgcaacagca tcttgcctga tttgtaaata caaagttgac tgtgaagctg 1200 tacgaggaga tatttttaat caggtagttc ctcgatgtcc taggtgccca gctgatgaac 1260 cgcttgctat catgaaacca gagattgtgt tttttggtga aaatttacca gaacagtttc 1320 atagagccat gaagtatgac aaagatgaag ttgacctcct cattgttatt gggtcttccc 1380 tcaaagtaag accagtagca ctaattccaa gttccatacc ccatgaagtg cctcagatat 1440 taattaatag agaacctttg cctcatctgc attttgatgt agagcttctt ggagactgtg 1500 atgtcataat taatgaattg tgtcataggt taggtggtga atatgccaaa ctttgctgta 1560 accctgtaaa gctttcagaa attactgaaa aacctccacg aacacaaaaa gaattggctt 1620 atttgtcaga gttgccaccc acacctcttc atgtttcaga agactcaagt tcaccagaaa 1680 gaacttcacc accagattct tcagtgattg tcacactttt agaccaagca gctaagagta 1740 atgatgattt agatgtgtct gaatcaaaag gttgtatgga agaaaaacca caggaagtac 1800 aaacttctag gaatgttgaa agtattgctg aacagatgga aaatccggat ttgaagaatg 1860 ttggttctag tactggggag aaaaatgaaa gaacttcagt ggctggaaca gtgagaaaat 1920 gctggcctaa tagagtggca aaggagcaga ttagtaggcg gcttgatggt aatcagtatc 1980 tgtttttgcc accaaatcgt tacattttcc atggcgctga ggtatattca gactctgaag 2040 atgacgtctt atcctctagt tcttgtggca gtaacagtga tagtgggaca tgccagagtc 2100 caagtttaga agaacccatg gaggatgaaa gtgaaattga agaattctac aatggcttag 2160 aagatgagcc tgatgttcca gagagagctg gaggagctgg atttgggact gatggagatg 2220 atcaagaggc aattaatgaa gctatatctg tgaaacagga agtaacagac atgaactatc 2280 catcaaacaa atcatagtgt aataattgtg caggtacagg aattgttcca ccagcattag 2340 gaactttagc atgtcaaaat gaatgtttac ttgtgaactc gatagagcaa ggaaaccaga 2400 aaggtgtaat atttataggt tggtaaaata gattgttttt catggataat ttttaacttc 2460 attatttctg tacttgtaca aactcaacac taactttttt ttttttaaaa aaaaaaaggt 2520 actaagtatc ttcaatcagc tgttgggtca agactaactt tcttttaaag gttcatttgt 2580 atgataaatt catatgtgta tatataattt tttttgtttt gtctagtgag tttcaacatt 2640 tttaaagttt tcaaaaagcc atcggaatgt taaattaatg taaagggaca gctaatctag 2700 accaaagaat ggtattttca cttttctttg taacattgaa tggtttgaag tactcaaaat 2760 ctgttacgct aaacttttga ttctttaaca caattatttt taaacactgg cattttccaa 2820 aactgtggca gctaactttt taaaatctca aatgacatgc agtgtgagta gaaggaagtc 2880 aacaatatgt ggggagagca ctcggttgtc tttactttta aaagtaatac ttggtgctaa 2940 gaatttcagg attattgtat ttacgttcaa atgaagatgg cttttgtact tcctgtggac 3000 atgtagtaat gtctatattg gctcataaaa ctaacctgaa aaacaaataa atgctttgga 3060 aatgtttcag ttgctttaga aacattagtg cctgcctgga tccccttagt tttgaaatat 3120 ttgccattgt tgtttaaata cctatcactg tggtagagct tgcattgatc ttttccacaa 3180 gtattaaact gccaaaatgt gaatatgcaa agcctttctg aatctataat aatggtactt 3240 ctactgggga gagtgtaata ttttggactg ctgttttcca ttaatgagga gagcaacagg 3300 cccctgatta tacagttcca aagtaataag atgttaattg taattcagcc agaaagtaca 3360 tgtctcccat tgggaggatt tggtgttaaa taccaaactg ctagccctag tattatggag 3420 atgaacatga tgatgtaact tgtaatagca gaatagttaa tgaatgaaac tagttcttat 3480 aatttatctt tatttaaaag cttagcctgc cttaaaacta gagatcaact ttctcagctg 3540 caaaagcttc tagtctttca agaagttcat actttatgaa attgcacagt aagcatttat 3600 ttttcagacc atttttgaac atcactccta aattaataaa gtattcctct gttgctttag 3660 tatttattac aataaaaagg gtttgaaata tagctgttct ttatgcataa aacacccagc 3720 taggaccatt actgccagag aaaaaaatcg tattgaatgg ccatttccct acttataaga 3780 tgtctcaatc tgaatttatt tggctacact aaagaatgca gtatatttag ttttccattt 3840 gcatgatgtt tgtgtgctat agatgatatt ttaaattgaa aagtttgttt taaattattt 3900 ttacagtgaa gactgttttc agctcttttt atattgtaca tagtctttta tgtaatttac 3960 tggcatatgt tttgtagact gtttaatgac tggatatctt ccttcaactt ttgaaataca 4020 aaaccagtgt tttttacttg tacactgttt taaagtctat taaaattgtc atttgacttt 4080 tttctg 4086 <210> 836 <211> 4040 <212> DNA <213> Homo sapiens <400> 836 gcgggagcag aggaggcgag ggaggagggc cagagaggca gttggaagat ggcggacgag 60 gcggccctcg cccttcagcc cggcggctcc ccctcggcgg cgggggccga cagggaggcc 120 gcgtcgtccc ccgccgggga gccgctccgc aagaggccgc ggagagatgg tcccggcctc 180 gagcggagcc cgggcgagcc cggtggggcg gccccagagc gtgaggtgcc ggcggcggcc 240 aggggctgcc cgggtgcggc ggcggcggcg ctgtggcggg aggcggaggc agaggcggcg 300 gcggcaggcg gggagcaaga ggcccaggcg actgcggcgg ctggggaagg agacaatggg 360 ccgggcctgc agggcccatc tcgggagcca ccgctggccg acaacttgta cgacgaagac 420 gacgacgacg agggcgagga ggaggaagag gcggcggcgg cggcgattgg gtaccgagat 480 aaccttctgt tcggtgatga aattatcact aatggttttc attcctgtga aagtgatgag 540 gaggatagag cctcacatgc aagctctagt gactggactc caaggccacg gataggtcca 600 tatacttttg ttcagcaaca tcttatgatt ggcacagatc ctcgaacaat tcttaaagat 660 ttattgccgg aaacaatacc tccacctgag ttggatgata tgacactgtg gcagattgtt 720 attaatatcc tttcagaacc accaaaaagg aaaaaaagaa aagatattaa tacaattgaa 780 gatgctgtga aattactgca agagtgcaaa aaaattatag ttctaactgg agctggggtg 840 tctgtttcat gtggaatacc tgacttcagg tcaagggatg gtatttatgc tcgccttgct 900 gtagacttcc cagatcttcc agatcctcaa gcgatgtttg atattgaata tttcagaaaa 960 gatccaagac cattcttcaa gtttgcaaag gaaatatatc ctggacaatt ccagccatct 1020 ctctgtcaca aattcatagc cttgtcagat aaggaaggaa aactacttcg caactatacc 1080 cagaacatag acacgctgga acaggttgcg ggaatccaaa ggataattca gtgtcatggt 1140 tcctttgcaa cagcatcttg cctgatttgt aaatacaaag ttgactgtga agctgtacga 1200 ggagatattt ttaatcaggt agttcctcga tgtcctaggt gcccagctga tgaaccgctt 1260 gctatcatga aaccagagat tgtgtttttt ggtgaaaatt taccagaaca gtttcataga 1320 gccatgaagt atgacaaaga tgaagttgac ctcctcattg ttattgggtc ttccctcaaa 1380 gtaagaccag tagcactaat tccaagttcc ataccccatg aagtgcctca gatattaatt 1440 aatagagaac ctttgcctca tctgcatttt gatgtagagc ttcttggaga ctgtgatgtc 1500 ataattaatg aattgtgtca taggttaggt ggtgaatatg ccaaactttg ctgtaaccct 1560 gtaaagcttt cagaaattac tgaaaaacct ccacgaacac aaaaagaatt ggcttatttg 1620 tcagagttgc cacccacacc tcttcatgtt tcagaagact caagttcacc agaaagaact 1680 tcaccaccag attcttcagt gattgtcaca cttttagacc aagcagctaa gagtaatgat 1740 gatttagatg tgtctgaatc aaaaggttgt atggaagaaa aaccacagga agtacaaact 1800 tctaggaatg ttgaaagtat tgctgaacag atggaaaatc cggatttgaa gaatgttggt 1860 tctagtactg gggagaaaaa tgaaagaact tcagtggctg gaacagtgag aaaatgctgg 1920 cctaatagag tggcaaagga gcagattagt aggcggcttg atggtaatca gtatctgttt 1980 ttgccaccaa atcgttacat tttccatggc gctgaggtat attcagactc tgaagatgac 2040 gtcttatcct ctagttcttg tggcagtaac agtgatagtg ggacatgcca gagtccaagt 2100 ttagaagaac ccatggagga tgaaagtgaa attgaagaat tctacaatgg cttagaagat 2160 gagcctgatg ttccagagag agctggagga gctggatttg ggactgatgg agatgatcaa 2220 gaggcaatta atgaagctat atctgtgaaa caggaagtaa cagacatgaa ctatccatca 2280 aacaaatcat agtgtaataa ttgtgcaggt acaggaattg ttccaccagc attaggaact 2340 ttagcatgtc aaaatgaatg tttacttgtg aactcgatag agcaaggaaa ccagaaaggt 2400 gtaatattta taggttggta aaatagattg tttttcatgg ataattttta acttcattat 2460 ttctgtactt gtacaaactc aacactaact tttttttttt taaaaaaaaa aaggtactaa 2520 gtatcttcaa tcagctgttg gtcaagacta actttctttt aaaggttcat ttgtatgata 2580 aattcatatg tgtatatata attttttttg ttttgtctag tgagtttcaa catttttaaa 2640 gttttcaaaa agccatcgga atgttaaatt aatgtaaagg gaacagctaa tctagaccaa 2700 agaatggtat tttcactttt ctttgtaaca ttgaatggtt tgaagtactc aaaatctgtt 2760 acgctaaact tttgattctt taacacaatt atttttaaac actggcattt tccaaaactg 2820 tggcagctaa ctttttaaaa tctcaaatga catgcagtgt gagtagaagg aagtcaacaa 2880 tatgtgggga gagcactcgg ttgtctttac ttttaaaagt aatacttggt gctaagaatt 2940 tcaggattat tgtatttacg ttcaaatgaa gatggctttt gtacttcctg tggacatgta 3000 gtaatgtcta tattggctca taaaactaac ctgaaaaaca aataaatgct ttggaaatgt 3060 ttcagttgct ttagaaacat tagtgcctgc ctggatcccc ttagttttga aatatttgcc 3120 attgttgttt aaatacctat cactgtggta gagcttgcat tgatcttttc cacaagtatt 3180 aaactgccaa aatgtgaata tgcaaagcct ttctgaatct ataataatgg tacttctact 3240 ggggagagtg taatattttg gactgctgtt ttccattaat gaggagagca acaggcccct 3300 gattatacag ttccaaagta ataagatgtt aattgtaatt cagccagaaa gtacatgtct 3360 cccattggga ggatttggtg ttaaatacca aactgctagc cctagtatta tggagatgaa 3420 catgatgatg taacttgtaa tagctagaat agttaatgaa tgaaactagt tcttataatt 3480 tatctttatt taaaagcttc tagtctttca agaagttcat actttatgaa attgcacagt 3540 aagcatttat ttttcagacc atttttgaac atcactccta aattaataaa gtattcctct 3600 gttgctttag tatttattac aataaaaagg gtttgaaata tagctgttct ttatgcataa 3660 aacacccagc taggaccatt actgccagag aaaaaaatcg tattgaatgg ccatttccct 3720 acttataaga tgtctcaatc tgaatttatt tggctacact aaagaatgca gtatatttag 3780 ttttccattt gcatgatgtt tgtgtgctat agatgatatt ttaaattgaa aagtttgttt 3840 taaattattt ttacagtgaa gactgttttc agctcttttt atattgtaca tagtctttta 3900 tgtaatttac tggcatatgt tttgtagact gtttaatgac tggatatctt ccttcaactt 3960 ttgaaataca aaaccagtgt tttttacttg tacacactgt tttaaagtct attaaaattg 4020 tcatttgact tttttctgtt 4040 <210> 837 <211> 3719 <212> DNA <213> Homo sapiens <400> 837 gggaggcgga ggcccaggcg acaacttgta cgacgaagac gacgacgacg agggcgagga 60 ggaggaagag gcggcggcgg cggcgattgg gtaccgagat aaccttctgt tcggtgatga 120 aattatcact aatggttttc attcctgtga aagtgatgag gaggatagag cctcacatgc 180 aagctctagt gactggactc caaggccacg gataggtcca tatacttttg ttcagcaaca 240 tcttatgatt ggcacagatc ctcgaacaat tcttaaagat ttattgccgg aaacaatacc 300 tccacctgag ttggatgata tgacactgtg gcagattgtt attaatatcc tttcagaacc 360 accaaaaagg aaaaaaagaa aagatattaa tacaattgaa gatgctgtga aattactgca 420 agagtgcaaa aaaattatag ttctaactgg agctggggtg tctgtttcat gtggaatacc 480 tgacttcagg tcaagggatg gtatttatgc tcgccttgct gtagacttcc cagatcttcc 540 agatcctcaa gcgatgtttg atattgaata tttcagaaaa gatccaagac cattcttcaa 600 gtttgcaaag gaaatatatc ctggacaatt ccagccatct ctctgtcaca aattcatagc 660 cttgtcagat aaggaaggaa aactacttcg caactatacc cagaacatag acacgctgga 720 acaggttgcg ggaatccaaa ggataattca gtgtcatggt tcctttgcaa cagcatcttg 780 cctgatttgt aaatacaaag ttgactgtga agctgtacga ggagatattt ttaatcaggt 840 agttcctcga tgtcctaggt gcccagctga tgaaccgctt gctatcatga aaccagagat 900 tgtgtttttt ggtgaaaatt taccagaaca gtttcataga gccatgaagt atgacaaaga 960 tgaagttgac ctcctcattg ttattgggtc ttccctcaaa gtaagaccag tagcactaat 1020 tccaagttcc ataccccatg aagtgcctca gatattaatt aatagagaac ctttgcctca 1080 tctgcatttt gatgtagagc ttcttggaga ctgtgatgtc ataattaatg aattgtgtca 1140 taggttaggt ggtgaatatg ccaaactttg ctgtaaccct gtaaagcttt cagaaattac 1200 tgaaaaacct ccacgaacac aaaaagaatt ggcttatttg tcagagttgc cacccacacc 1260 tcttcatgtt tcagaagact caagttcacc agaaagaact tcaccaccag attcttcagt 1320 gattgtcaca cttttagacc aagcagctaa gagtaatgat gatttagatg tgtctgaatc 1380 aaaaggttgt atggaagaaa aaccacagga agtacaaact tctaggaatg ttgaaagtat 1440 tgctgaacag atggaaaatc cggatttgaa gaatgttggt tctagtactg gggagaaaaa 1500 tgaaagaact tcagtggctg gaacagtgag aaaatgctgg cctaatagag tggcaaagga 1560 gcagattagt aggcggcttg atggtaatca gtatctgttt ttgccaccaa atcgttacat 1620 tttccatggc gctgaggtat attcagactc tgaagatgac gtcttatcct ctagttcttg 1680 tggcagtaac agtgatagtg ggacatgcca gagtccaagt ttagaagaac ccatggagga 1740 tgaaagtgaa attgaagaat tctacaatgg cttagaagat gagcctgatg ttccagagag 1800 agctggagga gctggatttg ggactgatgg agatgatcaa gaggcaatta atgaagctat 1860 atctgtgaaa caggaagtaa cagacatgaa ctatccatca aacaaatcat agtgtaataa 1920 ttgtgcaggt acaggaattg ttccaccagc attaggaact ttagcatgtc aaaatgaatg 1980 tttacttgtg aactcgatag agcaaggaaa ccagaaaggt gtaatattta taggttggta 2040 aaatagattg tttttcatgg ataattttta acttcattat ttctgtactt gtacaaactc 2100 aacactaact tttttttttt ttaaaaaaaa aaaggtacta agtatcttca atcagctgtt 2160 ggtcaagact aacttttaaa ggttcatttg tatgataaat tcatatgtgt atatataatt 2220 ttttttgttt tgtctagtga gtttcaacat ttttaaagtt ttcaaaaagc catcggaatg 2280 ttaaattaat gtaaagggaa cagctaatct agaccaaaga atggtatttt cacttttctt 2340 tgtaacattg aatggtttga agtactcaaa atctgttacg ctaaactttt gattctttaa 2400 cacaattatt tttaaacact ggcattttcc aaaactgtgg cagctaactt tttaaaatct 2460 caaatgacat gcgtgtgagt agaaggaagt caacaatatg tggggagagc actcggttgt 2520 ctttactttt aaaagtaata cttggtgcta agaatttcag gattattgta tttacgttca 2580 aatgaagatg gcttttgtac ttcctgtgga catgtagtaa tgtctatatt ggctcataaa 2640 actaacctga aaaacaaata aatgctttgg aaatgtttca gttgctttag aaacattagt 2700 gcctgcctgg atccccttag ttttgaaata tttgccattg ttgtttaaat acctatcact 2760 gtggtagagc ttgcattgat cttttccaca agtattaaac tgccaaaatg tgaatatgca 2820 aagcctttct gaatctataa taatggtact tctactgggg agagtgtaat attttggact 2880 gctgttttcc attaatgagg agagcaacag gcccctgatt atacagttcc aaagtaataa 2940 gatgttaatt gtaattcagc cagaaagtac atgtctccca ttgggaggat ttggtgttaa 3000 ataccaaact gctagcccta gtattatgga gatgaacatg atgatgtaac ttgtaatagc 3060 agaatagtta atgaatgaaa ctagttctta taatttatct ttatttaaaa gcttagcctg 3120 ccttaaaact agagatcaac tttctcagct gcaaaagctt ctagtctttc aagaagttca 3180 tactttatga aattgcacag taagcattta tttttcagac catttttgaa catcactcct 3240 aaattaataa agtattcctc tgttgcttta gtatttatta caataaaaag ggtttgaaat 3300 atagctgttc tttatgcata aaacacccag ctaggaccat tactgccaga gaaaaaaatc 3360 gtattgaatg gccatttccc tacttataag atgtctcaat ctgaatttat ttggctacac 3420 taaagaatgc agtatattta gttttccatt tgcatgatgt ttgtgtgcta tagatgatat 3480 tttaaattga aaagtttgtt ttaaattatt tttacagtga agactgtttt cagctctttt 3540 tatattgtac atagtctttt atgtaattta ctggcatatg ttttgtagac tgtttaatga 3600 ctggatatct tccttcaact tttgaaatac aaaactagtg ttttttactt gtacactgtt 3660 ttaaagtcta ttaaaattgt catttgactt ttttctgtta aaaaaaaaaa aaaaaaaaa 3719 <210> 838 <211> 3142 <212> DNA <213> Homo sapiens <400> 838 tgatattgaa tatttcagaa aagatccaag accattcttc aagtttgcaa aggaaatata 60 tcctggacaa ttccagccat ctctctgtca caaattcata gccttgtcag ataaggaagg 120 aaaactactt cgcaactata cccagaacat agacacgctg gaacaggttg cgggaatcca 180 aaggataatt cagtgtcatg gttcctttgc aacagcatct tgcctgattt gtaaatacaa 240 agttgactgt gaagctgtac gaggagatat ttttaatcag gtagttcctc gatgtcctag 300 gtgcccagct gatgaaccgc ttgctatcat gaaaccagag attgtgtttt ttggtgaaaa 360 tttaccagaa cagtttcata gagccatgaa gtatgacaaa gatgaagttg acctcctcat 420 tgttattggg tcttccctca aagtaagacc agtagcacta attccaagtt ccatacccca 480 tgaagtgcct cagatattaa ttaatagaga acctttgcct catctgcatt ttgatgtaga 540 gcttcttgga gactgtgatg tcataattaa tgaattgtgt cataggttag gtggtgaata 600 tgccaaactt tgctgtaacc ctgtaaagct ttcagaaatt actgaaaaac ctccacgaac 660 acaaaaagaa ttggcttatt tgtcagagtt gccacccaca cctcttcatg tttcagaaga 720 ctcaagttca ccagaaagaa cttcaccacc agattcttca gtgattgtca cacttttaga 780 ccaagcagct aagagtaatg atgatttaga tgtgtctgaa tcaaaaggtt gtatggaaga 840 aaaaccacag gaagtacaaa cttctaggaa tgttgaaagt attgctgaac agatggaaaa 900 tccggatttg aagaatgttg gttctagtac tggggagaaa aatgaaagaa cttcagtggc 960 tggaacagtg ggaaaatgct ggcctaatag agtggcaaag gagcagatta gtaggcggct 1020 tgatggtaat cagtatctgt ttttgccacc aaatcgttac attttccatg gcgctgaggt 1080 atattcagac tctgaagatg acgtcttatc ctctagttct tgtggcagta acagtgatag 1140 tgggacatgc cagagtccaa gtttagaaga acccatggag gatgaaagtg aaattgaaga 1200 attctacaat ggcttagaag atgagcctga tgttccagag agagctggag gagctggatt 1260 tgggactgat ggagatgatc aagaggcaat taatgaagct atatctgtga aacaggaagt 1320 aacagacatg aactatccat caaacaaatc atagtgtaat aattgtgcag gtacaggaat 1380 tgttccacca gcattaggaa ctttagcatg tcaaaatgaa tgtttacttg tgaactcgat 1440 agagcaagga aaccagaaag gtgtaatatt tataggttgg taaaatagat tgtttttcat 1500 ggataatttt taacttcatt atttctgtac ttgtacaaac tcaacactaa cttttttttt 1560 ttttaaaaaa aaaaaggtac taagtatctt caatcagctg ttggtcaaga ctaactttta 1620 aaggttcatt tgtatgataa attcatatgt gtatatataa ttttttttgt tttgtctagt 1680 gagtttcaac atttttaaag ttttcaaaaa gccatcggaa tgttaaatta atgtaaaggg 1740 aacagctaat ctagaccaaa gaatggtatt ttcacttttc tttgtaacat tgaatggttt 1800 gaagtactca aaatctgtta cgctaaactt ttgattcttt aacacaatta tttttaaaca 1860 ctggcatttt ccaaaactgt ggcagctaac tttttaaaat ctcaaatgac atgcagtgtg 1920 agtagaagga agtcaacaat atgtggggag agcactcggt tgtctttact tttaaaagta 1980 atacttggtg ctaagaattt caggattatt gtatttacgt tcaaatgaag atggcttttg 2040 tacttcctgt ggacatgtag taatgtctat attggctcat aaaactaacc tgaaaaacaa 2100 ataaatgctt tggaaatgtt tcagttgctt tagaaacatt agtgcctgcc tggatcccct 2160 tagttttgaa atatttgcca ttgttgttta aatacctatc actgtggtag agcttgcatt 2220 gatcttttcc acaagtatta aactgccaaa atgtgaatat gcaaagcctt tctgaatcta 2280 taataatggt acttctactg gggagagtgt aatattttgg actgctgttt tccattaatg 2340 aggagagcaa caggcccctg attatacagt tccaaagtaa taagatgtta attgtaattc 2400 agccagaaag tacatgtctc ccattgggag gatttggtgt taaataccaa actgctagcc 2460 ctagtattat ggagatgaac atgatgatgt aacttgtaat agcagaatag ttaatgaatg 2520 aaactagttc ttataattta tctttgttta aaagcttagc ctgccttaaa actagagatc 2580 aactttctca gctgcaaaag cttctagtct ttcaagaagt tcatacttta tgaaattgca 2640 cagtaagcat ttatttttca gaccattttt gaacatcact cctaaattaa taaagtattc 2700 ctctgttgct ttagtattta ttacaataaa aagggtttga aatatagctg ttctttatgc 2760 ataaaacacc cagctaggac cattactgcc agagaaaaaa atcgtattga atggccattt 2820 ccctacttat aagatgtctc aatctgaatt tatttggcta cactaaagaa tgcagtatat 2880 ttagttttcc atttgcatga tgtttgtgtg ctatagatga tattttaaat tgaaaagttt 2940 gttttaaatt atttttacag tgaagactgt tttcagctct ttttatattg tacatagtct 3000 tttatgtaat ttactggcat atgttttgta gactgtttaa tgactggata tcttccttca 3060 acttttgaaa tacaaaacca gtgtttttta cttgtacact gttttaaagt ctattaaaat 3120 tgtcatttga cttttttctg tt 3142 <210> 839 <211> 3691 <212> DNA <213> Homo sapiens <400> 839 aagacgacga cgacgagggc gaggaggagg aagaggcggc ggcggcggcg attgggtacc 60 gagataacct tctgttcggt gatgaaatta tcactaatgg ttttcattcc tgtgaaagtg 120 atgaggagga tagagcctca catgcaagct ctagtgactg gactccaagg ccacggatag 180 gtccatatac ttttgtccag caacatctta tgattggcac agatcctcga acaattctta 240 aagatttatt gccggaaaca atacctccac ctgagttgga tgatatgaca ctgtggcaga 300 ttgttattaa tatcctttca gaaccaccaa aaaggaaaaa aagaaaagat attaatacaa 360 ttgaagatgc tgtgaaatta ctgcaagagt gcaaaaaaat tatagttcta actggagctg 420 gggtgtctgt ttcatgtgga atacctgact tcaggtcaag ggatggtatt tatgctcgcc 480 ttgctgtaga cttcccagat cttccagatc ctcaagcgat gtttgatatt gaatatttca 540 gaaaagatcc aagaccattc ttcaagtttg caaaggaaat atatcctgga caattccagc 600 catctctctg tcacaaattc atagccttgt cagataagga aggaaaacta cttcgcaact 660 atacccagaa catagacacg ctggaacagg ttgcgggaat ccaaaggata attcagtgtc 720 atggttcctt tgcaacagca tcttgcctga tttgtaaata caaagttgac tgtgaagctg 780 tacgaggagc tctttttagt caggtagttc ctcgatgtcc taggtgccca gctgatgaac 840 cgcttgctat catgaaacca gagattgtgt tttttggtga aaatttacca gaacagtttc 900 atagagccat gaagtatgac aaagatgaag ttgacctcct cattgttatt gggtcttccc 960 tcaaagtaag accagtagca ctaattccaa gttccatacc ccatgaagtg cctcagatat 1020 taattaatag agaacctttg cctcatctgc attttgatgt agagcttctt ggagactgtg 1080 atgtcataat taatgaattg tgtcataggt taggtggtga atatgccaaa ctttgctgta 1140 accctgtaaa gctttcagaa attactgaaa aacctccacg aacacaaaaa gaattggctt 1200 atttgtcaga gttgccaccc acacctcttc atgtttcaga agactcaagt tcaccagaaa 1260 gaacttcacc accagattct tcagtgattg tcacactttt agaccaagca gctaagagta 1320 atgatgattt agatgtgtct gaatcaaaag gttgtatgga agaaaaacca caggaagtac 1380 aaacttctag gaatgttgaa agtattgctg aacagatgga aaatccggat ttgaagaatg 1440 ttggttctag tactggggag aaaaatgaaa gaacttcagt ggctggaaca gtgagaaaat 1500 gctggcctaa tagagtggca aaggagcaga ttagtaggcg gcttgatggt aatcagtatc 1560 tgtttttgcc accaaatcgt tacattttcc atggcgctga ggtatattca gactctgaag 1620 atgacgtctt atcctctagt tcttgtggca gtaacagtga tagtgggaca tgccagagtc 1680 caagtttaga agaacccatg gaggatgaaa gtgaaattga agaattctac aatggcttag 1740 aagatgagcc tgatgttcca gagagagctg gaggagctgg atttgggact gatggagatg 1800 atcaagaggc aattaatgaa gctatatctg tgaaacagga agtaacagac atgaactatc 1860 catcaaacaa atcatagtgt aataattgtg caggtacagg aattgttcca ccagcattag 1920 gaactttagc atgtcaaaat gaatgtttac ttgtgaactc gatagagcaa ggaaaccaga 1980 aaggtgtaat atttataggt tggtaaaata gattgttttt catggataat ttttaacttc 2040 attatttctg tacttgtaca aactcaacac taactttttt ttttttaaaa aaaaaaaggt 2100 actaagtatc ttcaatcagc tgttggtcaa gactaacttt cttttaaagg ttcatttgta 2160 tgataaattc atatgtgtat atataatttt tttttgtttt gtctagtgag tttcaacatt 2220 tttaaagttt tcaaaaagcc atcggaatgt taaattaatg taaagggaac agctaatcta 2280 gaccaaagaa tggtattttc acttttcttt gtaacattga atggtttgaa gtactcaaaa 2340 tctgttacgc taaacttttg attctttaac acaattattt ttaaacactg gcattttcca 2400 aaactgtggc agctaacttt ttaaaatctc aaatgacatg cagtgtgagt agaaggaagt 2460 caacaatatg tggggagagc actcggttgt ctttactttt aaaagtaata cttggtgcta 2520 agaatttcag gattattgta tttacgttca aatgaagatg gcttttgtac ttcctgtgga 2580 catgtagtaa tgtctatatt ggctcataaa actaacctga aaaacaaata aatgctttgg 2640 aaatgtttca gttgctttag aaacattagt gcctgcctgg atccccttag ttttgaaata 2700 tttgccattg ttgtttaaat acctatcact gtggtagagc ttgcattgat cttttccaca 2760 agtattaaac tgccaaaatg tgaatatgca aagcctttct gaatctataa taatggtact 2820 tctactgggg agagtgtaat attttggact gctgttttcc attaatgagg agagcaacag 2880 gcccctgatt atacagttcc aaagtaataa gatgttaatt gtaattcagc cagaaagtac 2940 atgtctccca ttgggaggat ttggtgttaa ataccaaact gctagcccta gtattatgga 3000 gatgaacatg atgatgtaac ttgtaatagc agaatagtta atgaatgaaa ctagttctta 3060 taatttatct ttatttaaaa gcttagcctg ccttaaaact agagatcaac tttctcagct 3120 gcaaaagctt ctagtctttc aagaagttca tactttatga aattgcacag taagcattta 3180 tttttcagac catttttgaa catcactcct aaattaataa agtattcctc tgttgcttta 3240 gtatttatta caataaaaag ggtttgaaat atagctgttc tttatgcata aaacacccag 3300 ctaggaccat tactgccaga gaaaaaaatc gtattgaatg gccatttccc tacttataag 3360 atgtctcaat ctgaatttat ttggctacac taaagaatgc agtatattta gttttccatt 3420 tgcatgatgt ttgtgtgcta tagatgatat tttaaattga aaagtttgtt ttaaattatt 3480 tttacagtga agactgtttt cagctctttt tatattgtac atagtctttt atgtaattta 3540 ctggcatatg ttttgtagac tgtttaatga ctggatatct tccttcaact tttgaaatac 3600 aaaaccagtg ttttttactt gtacactgtt ttaaagtcta ttaaaattgt catttgactt 3660 ttttctgtta acttaaaaaa aaaaaaaaaa a 3691 <210> 840 <211> 3284 <212> DNA <213> Homo sapiens <400> 840 cagatcctca agcgatgttt gatattgaat atttcagaaa agatccaaga ccattcttca 60 agtttgcaaa gaagaaacag cattgaagca ttatttgggg ggaaaaacac acacacaaaa 120 tccagcaact cagcattcat gagcaactct atactatacc agtatgtgcc tgtgcagtgg 180 aaggaaaaca attttggaaa tatatcctgg acaattccag ccatctctct gtcacaaatt 240 catagccttg tcagataagg aaggaaaact acttcgcaac tatacccaga acatagacac 300 gctggaacag gttgcgggaa tccaaaggat aattcagtgt catggttcct ttgcaacagc 360 atcttgcctg atttgtaaat acaaagttga ctgtgaagct gtacgaggag atatttttaa 420 tcaggtagtt cctcgatgtc ctaggtgccc agctgatgaa ccgcttgcta tcatgaaacc 480 agagattgtg ttttttggtg aaaatttacc agaacagttt catagagcca tgaagtatga 540 caaagatgaa gttgacctcc tcattgttat tgggtcttcc ctcaaagtaa gaccagtagc 600 actaattcca agttccatac cccatgaagt gcctcagata ttaattaata gagaaccttt 660 gcctcatctg cattttgatg tagagcttct tggagactgt gatgtcataa ttaatgaatt 720 gtgtcatagg ttaggtggtg aatatgccaa actttgctgt aaccctgtaa agctttcaga 780 aattactgaa aaacctccac gaacacaaaa agaattggct tatttgtcag agttgccacc 840 cacacctctt catgtttcag aagactcaag ttcaccagaa agaacttcac caccagattc 900 ttcagtgatt gtcacacttt tagaccaagc agctaagagt aatgatgatt tagatgtgtc 960 tgaatcaaaa ggttgtatgg aagaaaaacc acaggaagta caaacttcta ggaatgttga 1020 aagtattgct gaacagatgg aaaatccgga tttgaagaat gttggttcta gtactgggga 1080 gaaaaatgaa agaacttcag tggctggaac agtgagaaaa tgctggccta atagagtggc 1140 aaaggagcag attagtaggc ggcttgatgg taatcagtat ctgtttttgc caccaaatcg 1200 ttacattttc catggcgctg aggtatattc agactctgaa gatgacgtct tatcctctag 1260 ttcttgtggc agtaacagtg atagtgggac atgccagagt ccaagtttag aagaacccat 1320 ggaggatgaa agtgaaattg aagaattcta caatggctta gaagatgagc ctgatgttcc 1380 agagagagct ggaggagctg gatttgggac tgatggagat gatcaagagg caattaatga 1440 agctatatct gtgaaacagg aagtaacaga catgaactat ccatcaaaca aatcatagtg 1500 taataattgt gcaggtacag gaattgttcc accagcatta ggaactttag catgtcaaaa 1560 tgaatgttta cttgtgaact cgatagagca aggaaaccag aaaggtgtaa tatttatagg 1620 ttggtaaaat agattgtttt tcatggataa tttttaactt cattatttct gtacttgtac 1680 aaactcaaca ctaacttttt ttttttttaa aaaaaaaaag gtactaagta tcttcaatca 1740 gctgttggtc aagactaact tttaaaggtt catttgtatg ataaattcat atgtgtatat 1800 aatttttttt gttttgtcta gtgagtttca acatttttaa agttttcaaa aagccatcgg 1860 aatgttaaat taatgtaaag ggaacagcta atctagacca aagaatggta ttttcacttt 1920 tctttgtaac attgaatggt ttgaagtact caaaatctgt tacgctaaac ttttgattct 1980 ttaacacaat tatttttaaa cactggcatt ttccaaaact gtggcagcta actttttaaa 2040 atctcaaatg acatgcagtg tgagtagaag gaagtcaaca atatgtgggg agagcactcg 2100 gttgtcttta cttttaaaag taatacttgg tgctaagaat ttcaggatta ttgtatttac 2160 gttcaaatga agatggcttt tgtacttcct gtggacatgt agtaatgtct atattggctc 2220 ataaaactaa cctgaaaaac aaataaatgc gttggaaatg tttcagttgc tttagaaaca 2280 ttagtgcctg cctggatccc cttagttttg aaatatttgc cattgttgtt taaataccta 2340 tcactgtggt agagcttgca ttgatctttt ccacaagtat taaactgcca aaatgtgaat 2400 atgcaaagcc tttctgaatc tataataatg gtacttctac tggggagagt gtaatatttt 2460 ggactgctgt tttccattaa tgaggagagc aacaggcccc tgattataca gttccaaagt 2520 aataagatgt taattgtaat tcagccagaa agtacatgtc tcccattggg aggatttggt 2580 gttaaatacc aaactgctag ccctagtatt atggagatga acatgatgat gtaacttgta 2640 atagcagaat agttaatgaa tgaaactagt tcttataatt tatctttatt taaaagctta 2700 gcctgcctta aaactagaga tcaactttct cagctgcaaa agcttctagt ctttcaagaa 2760 gttcatactt tatgaaattg cacagtaagc atttattttt cagaccattt ttgaacatca 2820 ctcctaaatt aataaagtat tcctctgttg ctttagtatt tattacaata aaaagggttt 2880 gaaatatagc tgttctttat gcataaaaca cccagctagg accattactg ccagagaaaa 2940 aaatcgtatt gaatggccat ttccctactt ataagatgtc tcaatctgaa tttatttggc 3000 tacactaaag aatgcagtat atttagtttt ccatttgcat gatgtttgtg tgctatagat 3060 gatattttaa attgaaaagt ttgttttaaa ttatttttac agtgaagact gttttcagct 3120 ctttttatat tgtacatagt cttttatgta atttactggc atatgttttg tagactgttt 3180 aatgactgga tatcttcctt caacttttga aatacaaaac cagtgttttt tacttgtaca 3240 ctgttttaaa gtctattaaa attgtcattt gacttttttc tgtt 3284 <210> 841 <211> 6552 <212> DNA <213> Homo sapiens <400> 841 atgaggagct tcaaaagagt caactttggg actctgctaa gcagccagaa ggaggctgaa 60 gagttgctgc ccgacttgaa ggagttcctg tccaaccctc cagctggttt tcccagcagc 120 cgatctgatg ctgagaggag acaagcttgt gatgccatcc tgagggcttg caaccagcag 180 ctgactgcta agctagcttg ccctaggcat ctggggagcc tgctggagct ggcagagctg 240 gcctgtgatg gctacttagt gtctacccca cagcgtcctc ccctctacct ggaacgaatt 300 ctctttgtct tactgcggaa tgctgctgca caaggaagcc cagaggccac actccgcctt 360 gctcagcccc tccatgcctg cttggtgcag tgctctcgcg aggctgctcc ccaggactat 420 gaggccgtgg ctcggggcag cttttctctg ctttggaagg gggcagaagc cctgttggaa 480 cggcgagctg catttgcagc tcggctgaag gccttgagct tcctagtact cttggaggat 540 gaaagtaccc cttgtgaggt tcctcacttt gcttctccaa cagcctgtcg agcggtagct 600 gcccatcagc tatttgatgc cagtggccat ggtctaaatg aagcagatgc tgatttccta 660 gatgacctgc tctccaggca cgtgatcaga gccttggtgg gtgagagagg gagctcttct 720 gggcttcttt ctccccagag ggccctctgc ctcttggagc tcaccttgga acactgccgt 780 cgcttttgct ggagccgcca ccatgacaaa gccatcagcg cagtggagaa ggctcacagt 840 tacctaagga acaccaatct agcccctagc cttcagctat gtcagctggg ggttaagctg 900 ctgcaggttg gggaggaagg acctcaggca gtggccaagc ttctgatcaa ggcatcagct 960 gtcctgagca agagtatgga ggcaccatca cccccacttc gggcattgta tgagagctgc 1020 cagttcttcc tttcaggcct ggaacgaggc accaagaggc gctatagact tgatgccatt 1080 ctgagcctct ttgcttttct tggagggtac tgctctcttc tgcagcagct gcgggatgat 1140 ggtgtgtatg ggggctcctc caagcaacag cagtcttttc ttcagatgta ctttcaggga 1200 cttcacctct acactgtggt ggtttatgac tttgcccaag gctgtcagat agttgatttg 1260 gctgacctga cccaactagt ggacagttgt aaatctaccg ttgtctggat gctggaggcc 1320 ttagagggcc tgtcgggcca agagctgacg gaccacatgg ggatgaccgc ttcttacacc 1380 agtaatttgg cctacagctt ctatagtcac aagctctatg ccgaggcctg tgccatctct 1440 gagccgctct gtcagcacct gggtttggtg aagccaggca cttatcccga ggtgcctcct 1500 gagaagttgc acaggtgctt ccggctacaa gtagagagtt tgaagaaact gggtaaacag 1560 gcccagggct gcaagatggt gattttgtgg ctggcagccc tgcaaccctg tagccctgaa 1620 cacatggctg agccagtcac tttctgggtt cgggtcaaga tggatgcggc cagggctgga 1680 gacaaggagc tacagctaaa gactctgcga gacagcctca gtggctggga cccggagacc 1740 ctggccctcc tgctgaggga ggagctgcag gcctacaagg cggtgcgggc cgacactgga 1800 caggaacgct tcaacatcat ctgtgacctc ctggagctga gccccgagga gacaccagcc 1860 ggggcctggg cacgagccac ccacctggta gaactggctc aggtgctctg ctaccacgac 1920 tttacgcagc agaccaactg ctctgctctg gatgctatcc gggaagccct gcagcttctg 1980 gactctgtga ggcctgaggc ccaggccaga gatcagcttc tggacgataa agcacaggcc 2040 ttgctgtggc tttacatctg tactctggaa gccaaaatac aggaaggtat cgagcgggat 2100 cggagagccc aggcccctgg taacttggag gaatttgaag tcaatgacct gaactatgaa 2160 gataaactcc aggaagatcg tttcctatac agtaacattg ccttcaacct ggctgcagat 2220 gctgctcagt ccaaatgcct ggaccaagcc ctggccctgt ggaaggagct gcttacaaag 2280 gggcaggccc cagctgtacg gtgtctccag cagacagcag cctcactgca gatcctagca 2340 gccctctacc agctggtggc aaagcccatg caggctctgg aggtcctcct gctgctacgg 2400 attgtctctg agagactgaa ggaccactcg aaggcagctg gctcctcctg ccacatcacc 2460 cagctcctcc tgaccctcgg ctgtcccagc tatgcccagt tacacctgga agaggcagca 2520 tcgagcctga agcatctcga tcagactact gacacatacc tgctcctttc cctgacctgt 2580 gatctgcttc gaagtcaact ctactggact caccagaagg tgaccaaggg tgtctctctg 2640 ctgctgtctg tgcttcggga tcctgccctc cagaagtcct ccaaggcttg gtacttgctg 2700 cgtgtccagg tcctgcagct ggtggcagct taccttagcc tcccgtcaaa caacctctca 2760 cactccctgt gggagcagct ctgtgcccaa ggctggcaga cacctgagat agctctcata 2820 gactcccata agctcctccg aagcatcatc ctcctgctga tgggcagtga cattctctca 2880 actcagaaag cagctgtgga gacatcgttt ttggactatg gtgaaaatct ggtacaaaaa 2940 tggcaggttc tttcagaggt gctgagctgc tcagagaagc tggtctgcca cctgggccgc 3000 ctgggtagtg tgagtgaagc caaggccttt tgcttggagg ccctaaaact tacaacaaag 3060 ctgcagatac cacgccagtg tgccctgttc ctggtgctga agggcgagct ggagctggcc 3120 cgcaatgaca ttgatctctg tcagtcggac ctgcagcagg ttctgttctt gcttgagtct 3180 tgcacagagt ttggtggggt gactcagcac ctggactctg tgaagaaggt ccacctgcag 3240 aaggggaagc agcaggccca ggtcccctgt cctccacagc tcccagagga ggagctcttc 3300 ctaagaggcc ctgctctaga gctggtggcc actgtggcca aggagcctgg ccccatagca 3360 ccttctacaa actcctcccc agtcttgaaa accaagcccc agcccatacc caacttcctg 3420 tcccattcac ccacctgtga ctgctcgctc tgcgccagcc ctgtcctcac agcagtctgt 3480 ctgcgctggg tattggtcac ggcaggggtg aggctggcca tgggccacca agcccagggt 3540 ctggatctgc tgcaggtcgt gctgaagggc tgtcctgaag ccgctgagcg cctcacccaa 3600 gctctccaag cttccctgaa tcataaaaca cccccctcct tggttccaag cctcttggat 3660 gagatcttgg ctcaagcata cacactgttg gcactggagg gcctgaacca gccatcaaac 3720 gagagcctgc agaaggttct acagtcaggg ctgaagtttg tagcagcacg gataccccac 3780 ctagagccct ggcgagccag cctgctcttg atttgggccc tcacaaaact aggtggcctc 3840 agctgctgta ctacccaact ttttgcaagc tcctggggct ggcagccacc attaataaaa 3900 agtgtccctg gctcagagcc ctctaagact cagggccaaa aacgttctgg acgagggcgc 3960 caaaagttag cctctgctcc cctgcgcctc aataatacct ctcagaaagg tctggaaggt 4020 agaggactgc cctgcacacc taaaccccca gaccggatca ggcaagctgg ccctcatgtc 4080 cccttcacgg tgtttgagga agtctgccct acagagagca agcctgaagt accccaggcc 4140 cccagggtac aacagagagt ccagacgcgc ctcaaggtga acttcagtga tgacagtgac 4200 ttggaagacc ctgtctcagc tgaggcctgg ctggcagagg agcctaagag acggggcact 4260 gcttcccggg gccgggggcg agcaaggaag ggcctgagcc taaagacgga tgccgtggtt 4320 gccccaggta gtgcccctgg gaaccctggc ctgaatggca ggagccggag ggccaagaag 4380 gtggcatcaa gacattgtga ggagcggcgt ccccagaggg ccagtgacca ggccaggcct 4440 ggccctgaga tcatgaggac catccctgag gaagaactga ctgacaactg gagaaaaatg 4500 agctttgaga tcctcagggg ctctgacggg gaagactcag cctcaggtgg gaagactcca 4560 gctccgggcc ctgaggcagc ttctggagaa tgggagctgc tgaggctgga ttccagcaag 4620 aagaagctgc ccagcccatg cccagacaag gagagtgaca aggaccttgg tcctcggctc 4680 cagctcccct cagcccccgt agccactggt ctttctaccc tggactccat ctgtgactcc 4740 ctgagtgttg ctttccgggg cattagtcac tgtcctccta gtgggctcta tgcccacctc 4800 tgccgcttcc tggccttgtg cctgggccac cgggatcctt atgccactgc tttccttgtc 4860 accgagtctg tctccatcac ctgtcgccac cagctgctca cccacctcca cagacagctc 4920 agcaaggccc agaagcaccg aggatcactt gaaatagcag accagctgca ggggctgagc 4980 cttcaggaga tgcctggaga tgtccccctg gcccgcatcc agcgcctctt ttccttcagg 5040 gctttggaat ctggccactt cccccagcct gaaaaggaga gtttccagga gcgcctggct 5100 ctgatcccca gtggggtgac tgtgtgtgtg ttggccctgg ccaccctcca gcccggaacc 5160 gtgggcaaca ccctcctgct gacccggctg gaaaaggaca gtcccccagt cagtgtgcag 5220 attcccactg gccagaacaa gcttcatctg cgttcagtcc tgaatgagtt tgatgccatc 5280 cagaaggcac agaaagagaa cagcagctgt actgacaagc gagaatggtg gacagggcgg 5340 ctggcactgg accacaggat ggaggttctc atcgcttccc tagagaagtc tgtgctgggc 5400 tgctggaagg ggctgctgct gccgtccagt gaggagcccg gccctgccca ggaggcctcc 5460 cgcctacagg agctgctaca ggactgtggc tggaaatatc ctgaccgcac tctgctgaaa 5520 atcatgctca gtggtgccgg tgccctcacc cctcaggaca ttcaggccct ggcctacggg 5580 ctgtgcccaa cccagccaga gcgagcccag gagctcctga atgaggcagt aggacgtcta 5640 cagggcctga cagtaccaag caatagccac cttgtcttgg tcctagacaa ggacttgcag 5700 aagctgccgt gggaaagcat gcccagcctc caagcactgc ctgtcacccg gctgccctcc 5760 ttccgcttcc tactcagcta ctccatcatc aaagagtatg gggcctcgcc agtgctgagt 5820 caaggggtgg atccacgaag taccttctat gtcctgaacc ctcacaataa cctgtcaagc 5880 acagaggagc aatttcgagc caatttcagc agtgaagctg gctggagagg agtggttggg 5940 gaggtgccaa gacctgaaca ggtgcaggaa gccctgacaa agcatgattt gtatatctat 6000 gcagggcatg gggctggtgc ccgcttcctt gatgggcagg ctgtcctgcg gctgagctgt 6060 cgggcagtgg ccctgctgtt tggctgtagc agtgcggccc tggctgtgca tggaaacctg 6120 gagggggctg gcatcgtgct caagtacatc atggctggtt gccccttgtt tctgggtaat 6180 ctctgggatg tgactgaccg cgacattgac cgctacacgg aagctctgct gcaaggctgg 6240 cttggagcag gcccaggggc cccccttctc tactatgtaa accaggcccg ccaagctccc 6300 cgactcaagt atcttattgg ggctgcacct atagcctatg gcttgcctgt ctctctgcgg 6360 taaccccatg gagctgtctt attgatgcta gaagcctcat aactgttcta cctccaaggt 6420 tagatttaat ccttaggata actcttttaa agtgattttc cccagtgttt tatatgaaac 6480 atttcctttt gatttaacct cagtataata aagatacatc atttaaaccc tgaaaaaaaa 6540 aaaaaaaaaa aa 6552 <210> 842 <211> 2617 <212> DNA <213> Homo sapiens <400> 842 gctctcttct gcagcagctg cgggatgatg gtgtgtatgg gggctcctcc aagcaacagc 60 agtcttttct tcagatgtac tttcagggac ttcacctcta cactgtggtg gtttatgact 120 ttgcccaagg ctgtcagata gttgatttgg ctgacctgac ccaactagtg gacagttgta 180 aatctaccgt tgtctggatg ctggaggcct tagagggcct gtcgggccaa gagctgacgg 240 accacatggg gatgaccgct tcttacacca gtaatttggc ctacagcttc tatagtcaca 300 agctctatgc cgaggcctgt gccatctctg agccgctctg tcagcacctg ggtttggtga 360 agccaggcac ttatcccgag gtgcctcctg agaagttgca caggtgcttc cggctacaag 420 tagagagttt gaagaaactg ggtaaacagg cccagggctg caagatggtg attttgtggc 480 tggcagccct gcaaccctgt agccctgaac acatggctga gccagtcact ttctgggttc 540 gggtcaagat ggatgcggcc agggctggag acaaggagct acagctaaag actctgcgag 600 acagcctcag tggctgggac ccggagaccc tggccctcct gctgagggag gagctgcagg 660 cctacaaggc ggtgcgggcc gacactggac aggaacgctt caacatcatc tgtgacctcc 720 tggagctgag ccccgaggag acaccagccg gggcctgggc acgagccacc cacctggtag 780 aactggctca ggtgctctgc taccacgact ttacgcagca gaccaactgc tctgctctgg 840 atgctatccg ggaagccctg cagcttctgg actctgtgag gcctgaggcc caggccagag 900 atcagcttct ggacgataaa gcacaggcct tgctgtggct ttacatctgt actctggaag 960 ccaaaatgca ggaaggtatc gagcgggatc ggagagccca ggcccctggt aacttggagg 1020 aatttgaagt caatgacctg aactatgaag ataaactcca ggaagatcgt ttcctataca 1080 gtaacattgc cttcaacctg gctgcagatg ctgctcagtc caaatgcctg gaccaagccc 1140 tggccctgtg gaaggagctg cttacaaagg ggcaggcccc agctgtacgg tgtctccagc 1200 agacagcagc ctcactgcag atcctagcag ccctctacca gctggtggca aagcccatgc 1260 aggctctgga ggtcctcctg ctgctacgga ttgtctctga gagactgaag gaccactcga 1320 aggcagctgg ctcctcctgc cacatcaccc agctcctcct gaccctcggc tgtcccagct 1380 atgcccagtt acacctggaa gaggcagcat cgagcctgaa gcatctcgat cagactactg 1440 acacatacct gctcctttcc ctgacctgtg atctgcttcg aagtcaactc tactggactc 1500 accagaaggt gaccaagggt gtctctctgc tgctgtctgt gcttcgggat cctgccctcc 1560 agaagtcctc caaggcttgg tacttgctgc gtgtccaggt cctgcagctg gtggcagctt 1620 accttagcct cccgtcaaac aacctctcac actccctgtg ggagcagctc tgtgcccaag 1680 gctggcagac acctgagata gctctcatag actcccataa gctcctccga agcatcatcc 1740 tcctgctgat gggcagtgac attctctcaa ctcagaaagc agctgtggag acatcgtttt 1800 tggactatgg tgaaaatctg gtacaaaaat ggcaggttct ttcagaggtg ctgagctgct 1860 cagagaagct ggtctgccac ctgggccgcc tgggtagtgt gagtgaagcc aaggcctttt 1920 gcttggaggc cctaaaactt acaacaaagc tgcagatacc acgccagtgt gccctgttcc 1980 tggtgctgaa gggcgagctg gagctggccc gcaatgacat tgatctctgt cagtcggacc 2040 tgcagcaggt tctgttcttg cttgagtctt gcacagagtt tggtggggtg actcagcacc 2100 tggactctgt gaagaaggtc cacctgcaga aggggaagca gcaggcccag gtcccctgtc 2160 ctccacagct cccagaggag gagctcttcc taagaggccc tgctctagag ctggtggcca 2220 ctgtggccaa ggagcctggc cccatagcac cttctacaaa ctcctcccca gtcttgaaaa 2280 ccaagcccca gcccataccc aacttcctgt cccattcacc cacctgtgac tgctcgctct 2340 gcgccagccc tgtcctcaca gcagtctgtc tgcgctgggt attggtcacg gcaggggtga 2400 ggctggccat gggccaccaa gcccagggtc tggatctgct gcaggtcgtg ctgaagggct 2460 gtcctgaagc cgctgagcgc ctcacccaag ctctccaagc ttccctgaat cataaaacac 2520 cccccagacg aaaataccaa atgcaaaaaa aaaaaaaaaa aacaaaaaaa aaaaaaaaaa 2580 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa 2617 <210> 843 <211> 4074 <212> DNA <213> Homo sapiens <400> 843 tagagacggg gtttcactgt gttaaccagg atggtcttga tctcctgact tcgtgatcca 60 cccgcctcgg cctcccaaag tgctggggat taccggcgtg agccaccatg ctcagcctct 120 tttttttttt gagacggact ctcactctgt cgcccaggct ggagtacaat ggtgcgatct 180 cggcttactg caacctccac ctcccgggtt caagcaattt tgcctcagcc tcccgagtag 240 ctgggattac aggcgggtgc caccacaccc agcttattta tgtattttta gtaaagacgg 300 ggttttacca tgatggccag gctggtctca aactcctgac ctcaggtgat ccgcctgcct 360 cagcctccca aagtgctggg attacagacg tgagccactg tgccaggcca acatctttca 420 cagcaagacc tatttccaag tctccctttg tttcagacag agacattttc cttaactcta 480 atgtttcttt taccttttca tcccaccttc tgttccctca ttttctccct ccttccacac 540 ccaagagtcg ctgcccctga tctagagtgt tggctgtcat gtgagaagtt agttctgaaa 600 tcttccaggg tcctgtgtga tggtgcctga tggtgcctcc actgcgccac ctgctgtcac 660 aaggtgtctt gtcactgaag acctcttagc ccttcaccct ttcactctga tctcaggtga 720 acttcagtga tgacagtgac ttggaagacc ctgtctcagc tgaggcctgg ctggcagagg 780 agcctaagag acggggcact gcttcccggg gccgggggcg agcaaggaag ggcctgagcc 840 taatgacgga tgccgtggtt gccccaggta gtgcccctgg gaaccctggc ctgaatggca 900 ggagccggag ggccaagaag gtggcatcaa gacattgtga ggagcggcgt ccccagaggg 960 ccagtgacca ggccaggcct ggccctgaga tcatgaggac catccctgag gaagaactga 1020 ctgacaactg gagaaaaatg agctttgaga tcctcagggg ctctgacggg gaagactcag 1080 cctcaggtgg gaagactcca gctccgggcc ctgaggcagc ttctggagaa tgggagctgc 1140 tgaggctgga ttccagcaag aagaagctgc ccagcccatg cccagacaag gagagtgaca 1200 aggaccttgg tcctcggctc cagctcccct cagcccccgt agccactggt gaatatgcga 1260 cccctgatgt tggtcacttg gagagggctg agcctctagg gcttttgacc cctctgtctt 1320 tccaggctgg gttcggatct ggatccagta gcctctgaac ctgtgtttga accccagcac 1380 tctatgagct gtgtgcaggt cacttaacct ctccaagctt ctattccttc tgtaaaaatg 1440 gggtttaggg agcatggtgg aataagttga tgcctgttag ttgcatggca ccccacttgg 1500 cacattgccc ttcataaatg gtagttgctg tttgccatgt gggagatgag atagggactg 1560 ttccttcttg gaaagttcct atcaactatg aaataaggaa ttcagctgta ccaagtgtcc 1620 ttacgttctt ctaggtcttt ctaccctgga ctccatctgt gactccctga gtgttgcttt 1680 ccggggcatt agtcactgtc ctcctagtgg gctctatgcc cacctctgcc gcttcctggc 1740 cttgtgtctg ggccaccggg atccttatgc cactgctttc cttgtcaccg agtctgtctc 1800 catcacctgt cgccaccagc tgctcaccca cctccacaga cagctcagca aggcccagaa 1860 gcaccgagga tcacttgaaa tagcagacca gctgcagggg ctgagccttc aggagatgcc 1920 tggagatgtc cccctggccc gcatccagcg cctcttttcc ttcagggctt tggaatctgg 1980 ccacttcccc cagcctgaaa aggagagttt ccaggagcgc ctggctctga tccccagtgg 2040 tatgcgggca gccttctggc cggctcctct gtcctcttct gcatcttctt actttggagc 2100 tgggtgaagg agttttaggc attggttagt ttacatagat ttatgaccct tatgtcatac 2160 cttttcacct gttagcatct tacatcagga aggtttgttg ttttttttaa acctcaactt 2220 tgaattacca gcaaattcag tgtctttcct cagaggtgag ttcagatgac tggggtcttc 2280 tgtgctaaca tgaaacatat tcacatgatt tgagtgcctc actttgttag ttgctgtgag 2340 ggacacaaag tacaagtcat ggtctctgtg cacagggagc tattagagca agggagagca 2400 ccttgacctc tagtgaccag ggaaggcttc ttgatgctgg cttgagtgat ggataggaat 2460 tgagtgccca agacagggaa gggaattcct ttaacagctg aatgagtctg gctgtatcct 2520 gtgtgtcagg ggtgactgtg tgtgtgttgg ccctggccac cctccagccc ggaaccgtgg 2580 gcaacaccct cctgctgacc cggctggaaa aggacagtcc cccagtcagt gtgcagattc 2640 ccactggcca gaacaaggta ggattcctgg gccatggagc aaagttgggc tggattgggc 2700 ttcgggtcaa gctgctcaca ttctgtgttg agggagggag agatggtgat cacgtggaca 2760 agcagagctc tcacagcccc atctcccaaa gcttcatctg cgttcagtcc tgaatgagtt 2820 tgatgccatc cagaaggcac agaaagagaa cagcagctgt actgacaagc gagaatggtg 2880 gacagggcgg ctggcactgg accacaggat ggaggttctc atcgcttccc tagagaagtc 2940 tgtgctgggc tgctggaagg ggctgctgct gccgtccagt gaggagcccg gccctgccca 3000 ggaggcctcc cgcctacagg agctgctaca ggactgtggc tggaaatatc ctgaccgcac 3060 tctgctgaaa atcatgctca gtggtgccgg tgccctcacc cctcaggaca ttcaggccct 3120 ggcctacggg ctgtgcccaa cccagccaga gcgagcccag gagctcctga atgaggcagt 3180 aggacgtcta cagggcctga cagtaccaag caatagccac cttgtcttgg tcctagacaa 3240 ggacttgcag aagctgccgt gggaaagcat gcccagcctc caagcactgc ctgtcacccg 3300 gctgccctcc ttccgcttcc tactcagcta ctccatcatc aaagagtatg gggcctcgcc 3360 agtgctgagt caaggggtgg atccacgaag taccttctat gtcctgaacc ctcacaataa 3420 cctgtcaagc acagaggagc aatttcgagc caatttcagc agtgaagctg gctggagagg 3480 agtggttggg gaggtgccaa gacctgaaca ggtgcaggaa gccctgacaa agcatgattt 3540 gtatatctat gcagggcatg gggctggtgc ccgcttcctt gatgggcagg ctgtcctgcg 3600 gctgagctgt cgggcagtgg ccctgctgtt tggctgtagc agtgcggccc tggctgtgca 3660 tggaaacctg gagggggctg gcatcgtgct caagtacatc atggctggtt gccccttgtt 3720 tctgggtaat ctctgggatg tgactgaccg cgacattgac cgctacacgg aaactctgct 3780 gcaaggctgg cttggagcag gcccaggggc cccccttctc tactatgtaa accaggcccg 3840 ccaagctccc cgactcaagt atcttattgg ggctgcacct atagcctatg gcttgcctgt 3900 ctctctgcgg taaccccatg gagctgtctt attgatgcta gaagcctcat aactgttcta 3960 cctccaaggt tagatttaat ccttaggata actcttttaa agtgattttc cccagtgttt 4020 tatatgaaac atttcctttt ggtttaacct cagtataata aagatacatc attt 4074 <210> 844 <211> 6363 <212> DNA <213> Homo sapiens <400> 844 atgaggagct tcaaaagagt caactttggg actctgctaa gcagccagaa ggaggctgaa 60 gagttgctgc ccgacttgaa ggagttcctg tccaaccctc cagctggttt tcccagcagc 120 cgatctgatg ctgagaggag acaagcttgt gatgccatcc tgagggcttg caaccagcag 180 ctgactgcta agctagcttg ccctaggcat ctggggagcc tgctggagct ggcagagctg 240 gcctgtgatg gctacttagt gtctacccca cagcgtcctc ccctctacct ggaacgaatt 300 ctctttgtct tactgcggaa tgctgctgca caaggaagcc cagaggtcac actccgcctt 360 gctcagcccc tccatgcctg cttggtgcag tgctctcgcg aggctgctcc ccaggactat 420 gaggccgtgg ctcggggcag cttttctctg ctttggaagg gggcagaagc cctgttggaa 480 cggcgagctg catttgcagc tcggctgaag gccttgagct tcctagtact cttggaggat 540 gaaagtaccc cttgtgaggt tcctcacttt gcttctccaa cagcctgtcg agcggtagct 600 gcccatcagc tatttgatgc cagtggccat ggtctaaatg aagcagatgc tgatttccta 660 gatgacctgc tctccaggca cgtgatcaga gccttggtgg gtgagagagg gagctcttct 720 gggcttcttt ctccccagag ggccctctgc ctcttggagc tcaccttgga acactgccgt 780 cgcttttgct ggagccgcca ccatgacaaa gccatcagcg cagtggagaa ggctcacagt 840 tacctaagga acaccaatct agcccctagc cttcagctat gtcagctggg ggttaagctg 900 ctgcaggttg gggaggaagg acctcaggca gtggccaagc ttctgatcaa ggcatcagct 960 gtcctgagca agagtatgga ggcaccatca cccccacttc gggcattgta tgagagctgc 1020 cagttcttcc tttcaggcct ggaacgaggc accaagaggc gctatagact tgatgccatt 1080 ctgagcctct ttgcttttct tggagggtac tgctctcttc tgcagcagct gcgggatgat 1140 ggtgtgtatg ggggctcctc caagcaacag cagtcttttc ttcagatgta ctttcaggga 1200 cttcacctct acactgtggt ggtttatgac tttgcccaag gctgtcagat agttgatttg 1260 gctgacctga cccaactagt ggacagttgt aaatctaccg ttgtctggat gctggaggcc 1320 ttagagggcc tgtcgggcca agagctgacg gaccacatgg ggatgaccgc ttcttacacc 1380 agtaatttgg cctacagctt ctatagtcac aagctctatg ccgaggcctg tgccatctct 1440 gagccgctct gtcagcacct gggtttggtg aagccaggca cttatcccga ggtgcctcct 1500 gagaagttgc acaggtgctt ccggctacaa gtagagagtt tgaagaaact gggtaaacag 1560 gcccagggct gcaagatggt gattttgtgg ctggcagccc tgcaaccctg tagccctgaa 1620 cacatggctg agccagtcac tttctgggtt cgggtcaaga tggatgcggc cagggctgga 1680 gacaaggagc tacagctaaa gactctgcga gacagcctca gtggctggga cccggagacc 1740 ctggccctcc tgctgaggga ggagctgcag gcctacaagg cggtgcgggc cgacactgga 1800 caggaacgct tcaacatcat ctgtgacctc ctggagctga gccccgagga gacaccagcc 1860 ggggcctggg cacgagccac ccacctggta gaactggctc aggtgctctg ctaccacgac 1920 tttacgcagc agaccaactg ctctgctctg gatgctatcc gggaagccct gcagcttctg 1980 gactctgtga ggcctgaggc ccaggccaga gatcagcttc tggacgataa agcacaggcc 2040 ttgctgtggc tttacatctg tactctggaa gccaaaatac aggaaggtat cgagcgggat 2100 cggagagccc aggcccctgg taacttggag gaatttgaag tcaatgacct gaactatgaa 2160 gataaactcc aggaagatcg tttcctatac agtaacattg ccttcaacct ggctgcagat 2220 gctgctcagt ccaaatgcct ggaccaagcc ctggccctgt ggaaggagct gcttacaaag 2280 gggcaggccc cagctgtacg gtgtctccag cagacagcag cctcactgca gatcctagca 2340 gccctctacc agctggtggc aaagcccatg caggctctgg aggtcctcct gctgctacgg 2400 attgtctctg agagactgaa ggaccactcg aaggcagctg gctcctcctg ccacatcacc 2460 cagctcctcc tgaccctcgg ctgtcccagc tatgcccagt tacacctgga agaggcagca 2520 tcgagcctga agcatctcga tcagactact gacacatacc tgctcctttc cctgacctgt 2580 gatctgcttc gaagtcaact ctactggact caccagaagg tgaccaaggg tgtctctctg 2640 ctgctgtctg tgcttcggga tcctgccctc cagaagtcct ccaaggcttg gtacttgctg 2700 cgtgtccagg tcctgcagct ggtggcagct taccttagcc tcccgtcaaa caacctctca 2760 cactccctgt gggagcagct ctgtgcccaa ggctggcaga cacctgagat agctctcata 2820 gactcccata agctcctccg aagcatcatc ctcctgctga tgggcagtga cattctctca 2880 actcagaaag cagctgtgga gacatcgttt ttggactatg gtgaaaatct ggtacaaaaa 2940 tggcaggttc tttcagaggt gctgagctgc tcagagaagc tggtctgcca cctgggccgc 3000 ctgggtagtg tgagtgaagc caaggccttt tgcttggagg ccctaaaact tacaacaaag 3060 ctgcagatac cacgccagtg tgccctgttc ctggtgctga agggcgagct ggagctggcc 3120 cgcaatgaca ttgatctctg tcagtcggac ctgcagcagg ttctgttctt gcttgagtct 3180 tgcacagagt ttggtggggt gactcagcac ctggactctg tgaagaaggt ccacctgcag 3240 aaggggaagc agcaggccca ggtcccctgt cctccacagc tcccagagga ggagctcttc 3300 ctaagaggcc ctgctctaga gctggtggcc actgtggcca aggagcctgg ccccatagca 3360 ccttctacaa actcctcccc agtcttgaaa accaagcccc agcccatacc caacttcctg 3420 tcccattcac ccacctgtga ctgctcgctc tgcgccagcc ctgtcctcac agcagtctgt 3480 ctgcgctggg tattggtcac ggcaggggtg aggctggcca tgggccacca agcccagggt 3540 ctggatctgc tgcaggtcgt gctgaagggc tgtcctgaag ccgctgagcg cctcacccaa 3600 gctctccaag cttccctgaa tcataaaaca cccccctcct tggttccaag cctcttggat 3660 gagatcttgg ctcaagcata cacactgttg gcactggagg gcctgaacca gccatcaaac 3720 gagagcctgc agaaggttct acagtcaggg ctgaagtttg tagcagcacg gataccccac 3780 ctagagccct ggcgagccag cctgctcttg atttgggccc tcacaaaact aggtggcctc 3840 agctgctgta ctacccaact ttttgcaagc tcctggggct ggcagccacc attaataaaa 3900 agtgtccctg gctcagagcc ctctaagact cagggccaaa aacgttctgg acgagggcgc 3960 caaaagttag cctctgctcc cctgagcctc aataatacct ctcagaaagg tctggaaggt 4020 agaggactgc cctgcacacc taaaccccca gaccggatca ggcaagctgg ccctcatgtc 4080 cccttcacgg tgtttgagga agtctgccct acagagagca agcctgaagt accccaggcc 4140 cccagggtac aacagagagt ccagacgcgc ctcaaggtga acttcagtga tgacagtgac 4200 ttggaagacc ctgtctcagc tgaggcctgg ctggcagagg agcctaagag acggggcact 4260 gcttcccggg gccgggggcg agcaaggaag ggcctgagcc taaagacgga tgccgtggtt 4320 gccccaggta gtgcccctgg gaaccctggc ctgaatggca ggagccggag ggccaagaag 4380 gtggcatcaa gacattgtga ggagcggcgt ccccagaggg ccagtgacca ggccaggcct 4440 ggccctgaga tcatgaggac catccctgag gaagaactga ctgacaactg gagaaaaatg 4500 agctttgaga tcctcagggg ctctgacggg gaagactcag cctcaggtgg gaagactcca 4560 gctccgggcc ctgaggcagc ttctggagaa tgggagctgc tgaggctgga ttccagcaag 4620 aagaagctgc ccagcccatg cccagacaag gagagtgaca aggaccttgg tcctcggctc 4680 cagctcccct cagcccccgt agccactggt ctttctaccc tggactccat ctgtgactcc 4740 ctgagtgttg ctttccgggg cattagtcac tgtcctccta gtgggctcta tgcccacctc 4800 tgccgcttcc tggccttgtg cctgggccac cgggatcctt atgccactgc tttccttgtc 4860 accgagtctg tctccatcac ctgtcgccac cagctgctca cccacctcca cagacagctc 4920 agcaaggccc agaagcaccg aggatcactt gaaatagcag accagctgca ggggctgagc 4980 cttcaggaga tgcctggaga tgtccccctg gcccgcatcc agcgcctctt ttccttcagg 5040 gctttggaat ctggccactt cccccagcct gaaaaggaga gtttccagga gcgcctggct 5100 ctgatcccca gtggggtgac tgtgtgtgtg ttggccctgg ccaccctcca gcccggaacc 5160 gtgggcaaca ccctcctgct gacccggctg gaaaaggaca gtcccccagt cagtgtgcag 5220 attcccactg gccagaacaa gcttcatctg cgttcagtcc tgaatgagtt tgatgccatc 5280 cagaaggcac agaaagagaa cagcagctgt actgacaagc gagaatggtg gacagggcgg 5340 ctggcactgg accacaggat ggaggttctc atcgcttccc tagagaagtc tgtgctgggc 5400 tgctggaagg ggctgctgct gccgtccagt gaggagcccg gccctgccca ggaggcctcc 5460 cgcctacagg agctgctaca ggactgtggc tggaaatatc ctgaccgcac tctgctgaaa 5520 atcatgctca gtggtgccgg tgccctcacc cctcaggaca ttcaggccct ggcctacggg 5580 ctgtgcccaa cccagccaga gcgagcccag gagctcctga atgaggcagt aggacgtcta 5640 cagggcctga cagtaccaag caatagccac cttgtcttgg tcctagacaa ggacttgcag 5700 aagctgccgt gggaaagcat gcccagcctc caagcactgc ctgtcacccg gctgccctcc 5760 ttccgcttcc tactcagcta ctccatcatc aaagagtatg gggcctcgcc agtgctgagt 5820 caaggggtgg atccacgaag taccttctat gtcctgaacc ctcacaataa cctgtcaagc 5880 acagaggagc aatttcgagc caatttcagc agtgaagctg gctggagagg agtggttggg 5940 gaggtgccaa gacctgaaca ggtgcaggaa gccctgacaa agcatgattt gtatatctat 6000 gcagggcatg gggctggtgc ccgcttcctt gatgggcagg ctgtcctgcg gctgagctgt 6060 cgggcagtgg ccctgctgtt tggctgtagc agtgcggccc tggctgtgca tggaaacctg 6120 gagggggctg gcatcgtgct caagtacatc atggctggtt gccccttgtt tctgggtaat 6180 ctctgggatg tgactgaccg cgacattgac cgctacacgg aagctctgct gcaaggctgg 6240 cttggagcag gcccaggggc cccccttctc tactatgtaa accaggcccg ccaagctccc 6300 cgactcaagt atcttattgg ggctgcacct atagcctatg gcttgcctgt ctctctgcgg 6360 taa 6363 <210> 845 <211> 6662 <212> DNA <213> Homo sapiens <400> 845 ggcggttaag tcctgtacct aggaaagagg gcgagctctg gggcgctctc cggtgtcatg 60 aggagcttca aaagagtcaa ctttgggact ctgctaagca gccagaagga ggctgaagag 120 ttgctgcccg acttgaaggt gggggtgctg cctggctcgg gatacacctg gctttccaaa 180 ctgagctgtt ttgtgtttgc cttttgaaga gatggataag agttcctgtc caaccctcca 240 gctggttttc ccagcagccg atctgatgct gagaggagac aagcttgtga tgccatcctg 300 agggcttgca accagcagct gactgctaag ctagcttgcc ctaggcatct ggggagcctg 360 ctggagctgg cagagctggc ctgtgatggc tacttagtgt ctaccccaca gcgtcctccc 420 ctctacctgg aacgaattct ctttgtctta ctgcggaatg ctgctgcaca aggaagccca 480 gaggccacac tccgccttgc tcagcccctc catgcctgct tggtgcagtg ctctcgcgag 540 gctgctcccc aggactatga ggccgtggct cggggcagct tttctctgct ttggaagggg 600 gcagaagccc tgttggaacg gcgagctgca tttgcagctc ggctgaaggc cttgagcttc 660 ctagtactct tggaggatga aagtacccct tgtgaggttc ctcactttgc ttctccaaca 720 gcctgtcgag cggtagctgc ccatcagcta tttgatgcca gtggccatgg tctaaatgaa 780 gcagatgctg atttcctaga tgacctgctc tccaggcacg tgatcagagc cttggtgggt 840 gagagaggga gctcttctgg gcttctttct ccccagaggg ccctctgcct cttggagctc 900 accttggaac actgccgtcg cttttgctgg agccgccacc atgacaaagc catcagcgca 960 gtggagaagg ctcacagtta cctaaggaac accaatctag cccctagcct tcagctatgt 1020 cagctggggg ttaagctgct gcaggtcggg gaggaaggac ctcaggcagt ggccaagctt 1080 ctgatcaagg catcagctgt cctgagcaag agtatggagg caccatcacc cccacttcgg 1140 gcattgtatg agagctgcca gttcttcctt tcaggcctgg aacgaggcac caagaggcgc 1200 tatagacttg atgccattct gagcctcttt gcttttcttg gagggtactg ctctcttctg 1260 cagcagctgc gggatgatgg tgtgtatggg ggctcctcca agcaacagca gtcttttctt 1320 cagatgtact ttcagggact tcacctctac actgtggtgg tttatgactt tgcccaaggc 1380 tgtcagatag ttgatttggc tgacctgacc caactagtgg acagttgtaa atctaccgtt 1440 gtctggatgc tggaggcctt agagggcctg tcgggccaag agctgacgga ccacatgggg 1500 atgaccgctt cttacaccag taatttggcc tacagcttct atagtcacaa gctctatgcc 1560 gaggcctgtg ccatctctga gccgctctgt cagcacctgg gtttggtgaa gccaggcact 1620 tatcccgagg tgcctcctga gaagttgcac aggtgcttcc ggctacaagt agagagtttg 1680 aagaaactgg gtaaacaggc ccagggctgc aagatggtga ttttgtggct ggcagccctg 1740 caaccctgta gccctgaaca catggctgag ccagtcactt tctgggttcg ggtcaagatg 1800 gatgcggcca gggctggaga caaggagcta cagctaaaga ctctgcgaga cagcctcagt 1860 ggctgggacc cggagaccct ggccctcctg ctgagggagg agctgcaggc ctacaaggcg 1920 gtgcgggccg acactggaca ggaacgcttc aacatcatct gtgacctcct ggagctgagc 1980 cccgaggaga caccagccgg ggcctgggca cgagccaccc acctggtaga actggctcag 2040 gtgctctgct accacgactt tacgcagcag accaactgct ctgctctgga tgctatccgg 2100 gaagccctgc agcttctgga ctctgtgagg cctgaggccc aggccagaga tcagcttctg 2160 gacgataaag cacaggcctt gctgtggctt tacatctgta ctctggaagc caaaatacag 2220 gaaggtatcg agcgggatcg gagagcccag gcccctggta acttggagga atttgaagtc 2280 aatgacctga actatgaaga taaactccag gaagatcgtt tcctatacag taacattgcc 2340 ttcaacctgg ctgcagatgc tgctcagtcc aaatgcctgg accaagccct ggccctgtgg 2400 aaggagctgc ttacaaaggg gcaggcccca gctgtacggt gtctccagca gacagcagcc 2460 tcactgcaga tcctagcagc cctctaccag ctggtggcaa agcccatgca ggctctggag 2520 gtcctcctgc tgctacggat tgtctctgag agactgaagg accactcgaa ggcagctggc 2580 tcctcctgcc acatcaccca gctcctcctg accctcggct gtcccagcta tgcccagtta 2640 cacctggaag aggcagcatc gagcctgaag catctcgatc agactactga cacatacctg 2700 ctcctttccc tgacctgtga tctgcttcga agtcaactct actggactca ccagaaggtg 2760 accaagggtg tctctctgct gctgtctgtg cttcgggatc ctgccctcca gaagtcctcc 2820 aaggcttggt acttgctgcg tgtccaggtc ctgcagctgg tggcagctta ccttagcctc 2880 ccgtcaaaca acctctcaca ctccctgtgg gagcagctct gtgcccaagg ctggcagaca 2940 cctgagatag ctctcataga ctcccataag ctcctccgaa gcatcatcct cctgctgatg 3000 ggcagtgaca ttctctcaac tcagaaagca gctgtggaga catcgttttt ggactatggt 3060 gaaaatctgg tacaaaaatg gcaggttctt tcagaggtgc tgagctgctc agagaagctg 3120 gtctgccacc tgggccgcct gggtagtgtg agtgaagcca aggccttttg cttggaggcc 3180 ctaaaactta caacaaagct gcagatacca cgccagtgtg ccctgttcct ggtgctgaag 3240 ggcgagctgg agctggcccg caatgacatt gatctctgtc agtcggacct gcagcaggtt 3300 ctgttcttgc ttgagtcttg cacagagttt ggtggggtga ctcagcacct ggactctgtg 3360 aagaaggtcc acctgcagaa ggggaagcag caggcccagg tcccctgtcc tccacagctc 3420 ccagaggagg agctcttcct aagaggccct gctctagagc tggtggccac tgtggccaag 3480 gagcctggcc ccatagcacc ttctacaaac tcctccccag tcttgaaaac caagccccag 3540 cccataccca acttcctgtc ccattcaccc acctgtgact gctcgctctg cgccagccct 3600 gtcctcacag cagtctgtct gcgctgggta ttggtcacgg caggggtgag gctggccatg 3660 ggccaccaag cccagggtct ggatctgctg caggtcgtgc tgaagggctg tcctgaagcc 3720 gctgagcgcc tcacccaagc tctccaagct tccctgaatc ataaaacacc cccctccttg 3780 gttccaagcc tcttggatga gatcttggct caagcataca cactgttggc actggagggc 3840 ctgaaccagc catcaaacga gagcctgcag aaggttctac agtcagggct gaagtttgta 3900 gcagcacgga taccccacct agagccctgg cgagccagcc tgctcttgat ttgggccctc 3960 acaaaactag gtggcctcag ctgctgtact acccaacttt ttgcaagctc ctggggctgg 4020 cagccaccat taataaaaag tgtccctggc tcagagccct ctaagactca gggccaaaaa 4080 cgttctggac gagggcgcca aaagttagcc tctgctcccc tgagcctcaa taatacctct 4140 cagaaaggtc tggaaggtag aggactgccc tgcacaccta aacccccaga ccggatcagg 4200 caagctggcc ctcatgtccc cttcacggtg tttgaggaag tctgccctac agagagcaag 4260 cctgaagtac cccaggcccc cagggtacaa cagagagtcc agacgcgcct caaggtgaac 4320 ttcagtgatg acagtgactt ggaagaccct gtctcagctg aggcctggct ggcagaggag 4380 cctaagagac ggggcactgc ttcccggggc cgggggcgag caaggaaggg cctgagccta 4440 aagacggatg ccgtggttgc cccaggtagt gcccctggga accctggcct gaatggcagg 4500 agccggaggg ccaagaaggt ggcatcaaga cattgtgagg agcggcgtcc ccagagggcc 4560 agtgaccagg ccaggcctgg ccctgagatc atgaggacca tccctgagga agaactgact 4620 gacaactgga gaaaaatgag ctttgagatc ctcaggggct ctgacgggga agactcagcc 4680 tcaggtggga agactccagc tccgggccct gaggcagctt ctggagaatg ggagctgctg 4740 aggctggatt ccagcaagaa gaagctgccc agcccatgcc cagacaagga gagtgacaag 4800 gaccttggtc ctcggctcca gctcccctca gcccccgtag ccactggtct ttctaccctg 4860 gactccatct gtgactccct gagtgttgct ttccggggca ttagtcactg tcctcctagt 4920 gggctctatg cccacctctg ccgcttcctg gccttgtgcc tgggccaccg ggatccttat 4980 gccactgctt tccttgtcac cgagtctgtc tccatcacct gtcgccacca gctgctcacc 5040 cacctccaca gacagctcag caaggcccag aagcaccgag gatcacttga aatagcagac 5100 cagctgcagg ggctgagcct tcaggagatg cctggagatg tccccctggc ccgcatccag 5160 cgcctctttt ccttcagggc tttggaatct ggccacttcc cccagcctga aaaggagagt 5220 ttccaggagc gcctggctct gatccccagt ggggtgactg tgtgtgtgtt ggccctggcc 5280 accctccagc ccggaaccgt gggcaacacc ctcctgctga cccggctgga aaaggacagt 5340 cccccagtca gtgtgcagat tcccactggc cagaacaagc ttcatctgcg ttcagtcctg 5400 aatgagtttg atgccatcca gaaggcacag aaagagaaca gcagctgtac tgacaagcga 5460 gaatggtgga cagggcggct ggcactggac cacaggatgg aggttctcat cgcttcccta 5520 gagaagtctg tgctgggctg ctggaagggg ctgctgctgc cgtccagtga ggagcccggc 5580 cctgcccagg aggcctcccg cctacaggag ctgctacagg actgtggctg gaaatatcct 5640 gaccgcactc tgctgaaaat catgctcagt ggtgccggtg ccctcacccc tcaggacatt 5700 caggccctgg cctacgggct gtgcccaacc cagccagagc gagcccagga gctcctgaat 5760 gaggcagtag gacgtctaca gggcctgaca gtaccaagca atagccacct tgtcttggtc 5820 ctagacaagg acttgcagaa gctgccgtgg gaaagcatgc ccagcctcca agcactgcct 5880 gtcacccggc tgccctcctt ccgcttccta ctcagctact ccatcatcaa agagtatggg 5940 gcctcgccag tgctgagtca aggggtggat ccacgaagta ccttctatgt cctgaaccct 6000 cacaataacc tgtcaagcac agaggagcaa tttcgagcca atttcagcag tgaagctggc 6060 tggagaggag tggttgggga ggtgccaaga cctgaacagg tgcaggaagc cctgacaaag 6120 catgatttgt atatctatgc agggcatggg gctggtgccc gcttccttga tgggcaggct 6180 gtcctgcggc tgagctgtcg ggcagtggcc ctgctgtttg gctgtagcag tgcggccctg 6240 gctgtgcatg gaaacctgga gggggctggc atcgtgctca agtacatcat ggctggttgc 6300 cccttgtttc tgggtaatct ctgggatgtg actgaccgcg acattgaccg ctacacggaa 6360 gctctgctgc aaggctggct tggagcaggc ccaggggccc cccttctcta ctatgtaaac 6420 caggcccgcc aagctccccg actcaagtat cttattgggg ctgcacctat agcctatggc 6480 ttgcctgtct ctctgcggta accccatgga gctgtcttat tgatgctaga agcctcataa 6540 ctgttctacc tccaaggtta gatttaatcc ttaggataac tcttttaaag tgattttccc 6600 cagtgtttta tatgaaacat ttccttttga tttaacctca gtataataaa gatacatcat 6660 tt 6662 <210> 846 <211> 1108 <212> DNA <213> Homo sapiens <400> 846 cctgggcccc catgcccgtg cagctcgcac atatgtgggg cagagcagcc accctgcccc 60 cagcagcagc cgtccatcgt cagacgtgat catttcctga ggcctcgagt gtgtcagggt 120 gtttgtgcct cataacaacc cacaggatgg tcacccccgc tttgcagatg aagaaaccaa 180 agcagttttg ccgacggatg gggcaaaaga agcagcgacc agctagagca gggcagccac 240 acagctcgtc cgacgcagcc caggcacctg cagagcagcc acacagctcg tccgatgcag 300 cccaggcacc ttgccccagg gagcgctgct tgggaccgcc caccactccg ggcccatacc 360 gcagcatcta tttctcaagc ccaaagggcc accttacccg actggggttg gagttcttcg 420 accagccggc agtccccctg gcccgggcat ttctgggaca ggtcctagtc cggcgacttc 480 ctaatggcac agaactccga ggccgcatcg tggagaccga ggcatacctg gggccagagg 540 atgaaccggc ccactcaagg ggtggccggc agaccccccg caaccgaggc atgttcatga 600 agccggggac cctgtacgtg tacatcattt acggcatgta cttctgcatg aacatctcca 660 gccaggggga cggggcttgc gtcttgctgc gagcactgga gcccctggaa ggtctggaga 720 ccatgcgtca cgttcgcagc accctccgga aaggcaccgc cagccgtgtc ctcaaggacc 780 gcgagctctg cagtggcccc tccaagctgt gccaggccct ggccatcaac aagagctttg 840 accagaggga cctggcacag gatgaagctg tatggctgga gcgtggtccc ctggagccca 900 gtgagccggc tgtagtggca gcagcccggg tgggcgtcgg ccatgcaggg gagtgggccc 960 ggaaacccct ccgcttctat gtccggggca gcccctgggt cagtgtggtc gacagagtgg 1020 ctgagcagga cacacaggcc tgagcaaagg gcctgcccag acaagatttt ttaattgttt 1080 aaaaaccgaa taaatgtttt atttctag 1108 <210> 847 <211> 277 <212> DNA <213> Homo sapiens <400> 847 gagctttgac cagagggacc tggcacagga tgaagctgta tggctggagc gtggtcccct 60 ggagcccagt gagccggctg tagtggcagc agcccgggtg ggcgtcggcc atgcagggga 120 gtgggcccgg aaacccctcc gcttctatgt ccggggcagc ccctgggtca gtgtggtcga 180 cagagtggct gagcaggaca cacaggcctg agcaaagggc ctgcccagac aagatttttt 240 aattgtttaa aaaccgaata aatgttttat ttctaga 277 <210> 848 <211> 1108 <212> DNA <213> Homo sapiens <400> 848 cctgggcccc catgcccgtg cagctcgcac atatgtgggg cagagcagcc accctgcccc 60 cagcagcagc cgtccatcgt cagacgtgat catttcctga ggcctcgagt gtgtcagggt 120 gtttgtgcct cataacaacc cacaggatgg tcacccccgc tttgcagatg aagaaaccaa 180 agcagttttg ccgacggatg gggcaaaaga agcagcgacc agctagagca gggcagccac 240 acagctcgtc cgacgcagcc caggcacctg cagagcagcc acacagctcg tccgatgcag 300 cccaggcacc ttgccccagg gagcgctgct tgggaccgcc caccactccg ggcccatacc 360 gcagcatcta tttctcaagc ccaaagggcc accttacccg actggggttg gagttcttcg 420 accagccggc agtccccctg gcccgggcat ttctgggaca ggtcctagtc cggcgacttc 480 ctaatggcac agaactccga ggccgcatcg tggagaccga ggcatacctg gggccagagg 540 atgaaccggc ccactcaagg ggtggccggc agaccccccg caaccgaggc atgttcatga 600 agccggggac cctgtacgtg tacatcattt acggcatgta cttctgcatg aacatctcca 660 gccaggggga cggggcttgc gtcttgctgc gagcactgga gcccctggaa ggtctggaga 720 ccatgcgtca cgttcgcagc accctccgga aaggcaccgc cagccgtgtc ctcaaggacc 780 gcgagctctg cagtggcccc tccaagctgt gccaggccct ggccatcaac aagagctttg 840 accagaggga cctggcacag gatgaagctg tatggctgga gcgtggtccc ctggagccca 900 gtgagccggc tgtagtggca gcagcccggg tgggcgtcgg ccatgcaggg gagtgggccc 960 ggaaacccct ccgcttctat gtccggggca gcccctgggt cagtgtggtc gacagagtgg 1020 ctgagcagga cacacaggcc tgagcaaagg gcctgcccag acaagatttt ttaattgttt 1080 aaaaaccgaa taaatgtttt atttctag 1108 <210> 849 <211> 1027 <212> DNA <213> Homo sapiens <400> 849 gcaggcgccg ctccgccccg gtcctagggg tgcttccgtg gtcggcggct gctgggctcc 60 gcgccggggt ccgagtccca cgaagccccg gcccgagccg ccggatgccc gcgcgcagcg 120 gggcccagtt ttgccgacgg atggggcaaa agaagcagcg accagctaga gcagggcagc 180 cacacagctc gtccgacgca gcccaggcac ctgcagagca gccacacagc tcgtccgatg 240 cagcccaggc accttgcccc agggagcgct gcttgggacc gcccaccact ccgggcccat 300 accgcagcat ctatttctca agcccaaagg gccaccttac ccgactgggg ttggagttct 360 tcgaccagcc ggcagtcccc ctggcccggg catttctggg acaggtccta gtccggcgac 420 ttcctaatgg cacagaactc cgaggccgca tcgtggagac cgaggcatac ctggggccag 480 aggatgaagc cgcccactca aggggtggcc ggcagacccc ccgcaaccga ggcatgttca 540 tgaagccggg gaccctgtac gtgtacatca tttacggcat gtacttctgc atgaacatct 600 ccagccaggg ggacggggct tgcgtcttgc tgcgagcact ggagcccctg gaaggtctgg 660 agaccatgcg tcagcttcgc agcaccctcc ggaaaggcac cgccagccgt gtcctcaagg 720 accgcgagct ctgcagtggc ccctccaagc tgtgccaggc cctggccatc aacaagagct 780 ttgaccagag ggacctggca caggatgaag ctgtatggct ggagcgtggt cccctggagc 840 ccagtgagcc ggctgtagtg gcagcagccc gggtgggcgt cggccatgca ggggagtggg 900 cccggaaacc cctccgcttc tatgtccggg gcagcccctg ggtcagtgtg gtcgacagag 960 tggctgagca ggacacacag gcctgagcaa agggcctgcc cagacaagat tttttaattg 1020 tttaaaa 1027 <210> 850 <211> 1036 <212> DNA <213> Homo sapiens <400> 850 ggggtgcttc cgtggtcggc ggctgctggg ctccgcgccg gggtccgagt cccacgaagc 60 cccggcccga gccgccggat gcccgcgcgc agcggggccc agttttgccg acggatgggg 120 caaaagaagc agcgaccagc tagagcaggg cagccacaca gctcgtccga cgcagcccag 180 gcacctgcag agcagccaca cagctcgtcc gatgcagccc aggcaccttg ccccagggag 240 cgctgcttgg gaccgcccac cactccgggc ccataccgca gcatctattt ctcaagccca 300 aagggccacc ttacccgact ggggttggag ttcttcgacc agccggcagt ccccctggcc 360 cgggcatttc tgggacaggt cctagtccgg cgacttccta atggcacaga actccgaggc 420 cgcatcgtgg agaccgaggc atacctgggg ccagaggatg aagccgccca ctcaaggggt 480 ggccggcaga ccccccgcaa ccgaggcatg ttcatgaagc cggggaccct gtacgtgtac 540 atcatttacg gcatgtactt ctgcatgaac atctccagcc agggggacgg ggcttgcgtc 600 ttgctgcgag cactggagcc cctggaaggt ctggagacca tgcgtcagct tcgcagcacc 660 ctccggaaag gcaccgccag ccgtgtcctc aaggaccgcg agctctgcag tggcccctcc 720 aagctgtgcc aggccctggc catcaacaag agctttgacc agagggacct ggcacaggat 780 gaagctgtat ggctggagcg tggtcccctg gagcccagtg agccggctgt agtggcagca 840 gcccgggtgg gcgtcggcca tgcaggggag tgggcccgga aacccctccg cttctatgtc 900 cggggcagcc cctgggtcag tgtggtcgac agagtggctg agcaggacac acaggcctga 960 gcaaagggcc tgcccagaca agatttttta attgtttaaa aaccgaataa atgttttatt 1020 tctagaaaac tgtgcc 1036 <210> 851 <211> 988 <212> DNA <213> Homo sapiens <400> 851 ggtccgagtc ccacgaagcc ccggcccgag ccgccggatg cccgcgcgca gcggggccca 60 gttttgccga cggatggggc aaaagaagca gcgaccagct agagcagggc agccacacag 120 ctcgtccgac gcagcccagg cacctgcaga gcagccacac agctcgtccg atgcagccca 180 ggcaccttgc cccagggagc gctgcttggg accgcccacc actccgggcc cataccgcag 240 catctatttc tcaagcccaa agggccacct tacccgactg gggttggagt tcttcgacca 300 gccggcagtc cccctggccc gggcatttct gggacaggtc ctagtccggc gacttcctaa 360 tggcacagaa ctccgaggcc gcatcgtgga gaccgaggca tacctggggc cagaggatga 420 agccgcccac tcaaggggtg gccggcagac cccccgcaac cgaggcatgt tcatgaagcc 480 ggggaccctg tacgtgtaca tcatttacgg catgtacttc tgcatgaaca tctccagcca 540 gggggacggg gcttgcgtct tgctgcgagc actggagccc ctggaaggtc tggagaccat 600 gcgtcagctt cgcagcaccc tccggaaagg caccgccagc cgtgtcctca aggaccgcga 660 gctctgcagt ggcccctcca agctgtgcca ggccctggcc atcaacaaga gctttgacca 720 gagggacctg gcacaggatg aagctgtatg gctggagcgt ggtcccctgg agcccagtga 780 gccggctgta gtggcagcag cccgggtggg cgtcggccat gcaggggagt gggcccggaa 840 acccctccgc ttctatgtcc ggggcagccc ctgggtcagt gtggtcgaca gagtggctga 900 gcaggacaca caggcctgag caaagggcct gcccagacaa gattttttaa ttgtttaaaa 960 accgaataaa tgttttattt ctagaaaa 988 <210> 852 <211> 699 <212> DNA <213> Homo sapiens <400> 852 cgcagcatct atttctcaag cccaaagggc caccttaccc gactggggtt ggagttcttc 60 gaccagccgg cagtccccct ggcccgggca tttctgggac aggtcctagt ccggcgactt 120 cctaatggca cagaactccg aggccgcatc gtggagaccg aggcatacct ggggccagag 180 gatgaagccg cccactcaag gggtggccgg cagacccccc gcaaccgagg catgttcatg 240 aagccgggga ccctgtacgt gtacatcatt tacggcatgt acttctgcat gaacatctcc 300 agccaggggg acggggcttg cgtcttgctg cgagcactgg agcccctgga aggtctggag 360 accatgcgtc agcttcgcag caccctccgg aaaggcaccg ccagccgtgt cctcaaggac 420 cgcgagctct gcagtggccc ctccaagctg tgccaggccc tggccatcaa caagagcttt 480 gaccagaggg acctggcaca ggatgaagct gtatggctgg agcgtggtcc cctggagccc 540 agtgagccgg ctgtagtggc agcagcccgg gtgggcgtcg gccatgcagg ggagtgggcc 600 cggaaacccc tccgcttcta tgtccggggc agcccctggg tcagtgtggt cgacagagtg 660 gctgagcagg acacacaggc ctgagcaaag ggcctgccc 699 <210> 853 <211> 1143 <212> DNA <213> Homo sapiens <400> 853 ctgggctccg cgccggggtc cgagtcccac gaagccccgg cccgagccgc cggatgcccg 60 cgcgcagcgg ggcccaggtc atgcagcctg ggcccccatg ccgtgcagct cgcacatatg 120 tggggcagag cagccaccct gcccccagca gcagccgtcc atcgtcagac gtgatcattt 180 cctgaggcct cgagtgtgtc agggtgtttg tgcctcataa caacccacag gatggtcacc 240 cccgctttgc agatgaagaa accaaagcag ttttgccgac ggatggggca aaagaagcag 300 cgaccagcta gagcagggca gccacacagc tcgtccgacg cagcccaggc acctgcagag 360 cagccacaca gctcgtccga tgcagcccag gcaccttgcc ccagggagcg ctgcttggga 420 ccgcccacca ctccgggccc ataccgcagc atctatttct caagcccaaa gggccacctt 480 acccgactgg ggttggagtt cttcgaccag ccggcagtcc ccctggcccg ggcatttctg 540 ggacaggtcc tagtccggcg acttcctaat ggcacagaac tccgaggccg catcgtggag 600 accgaggcat acctggggcc agaggatgaa gccgcccact caaggggtgg ccggcagacc 660 ccccgcaacc gaggcatgtt catgaagccg gggaccctgt acgtgtacat catttacggc 720 atgtacttct gcatgaacat ctccagccag ggggacgggg cttgcgtctt gctgcgagca 780 ctggagcccc tggaaggtct ggagaccatg cgtcagcttc gcagcaccct ccggaaaggc 840 accgccagcc gtgtcctcaa ggaccgcgag ctctgcagtg gcccctccaa gctgtgccag 900 gccctggcca tcaacaagag ctttgaccag agggacctgg cacaggatga agctgtatgg 960 ctggagcgtg gtcccctgga gcccagtgag ccggctgtag tggcagcagc ccgggtgggc 1020 gtcggccatg caggggagtg ggcccggaaa cccctccgct tctatgtccg gggcagcccc 1080 tgggtcagtg tggtcgacag agtggctgag caggacacac aggcctgagc aaagggcctg 1140 ccc 1143 <210> 854 <211> 956 <212> DNA <213> Homo sapiens <400> 854 gatgcccgcg cgcagcgggg cccagttttg ccgacggatg gggcaaaaga agcagcgacc 60 agctagagca gggcagccac acagctcgtc cgacgcagcc caggcacctg cagagcagcc 120 acacagctcg tccgatgcag cccaggcacc ttgccccagg gagcgctgct tgggaccgcc 180 caccactccg ggcccatacc gcagcatcta tttctcaagc ccaaagggcc accttacccg 240 actggggttg gagttcttcg accagccggc agtccccctg gcccgggcat ttctgggaca 300 ggtcctagtc cggcgacttc ctaatggcac agaactccga ggccgcatcg tggagaccga 360 ggcatacctg gggccagagg atgaagccgc ccactcaagg ggtggccggc agaccccccg 420 caaccgaggc atgttcatga agccggggac cctgtacgtg tacatcattt acggcatgta 480 cttctgcatg aacatctcca gccaggggga cggggcttgc gtcttgctgc gagcactgga 540 gcccctggaa ggtctggaga ccatgcgtca cgttcgcagc accctccgga aaggcaccgc 600 cagccgtgtc ctcaaggacc gcgagctctg cagtggcccc tccaagctgt gccaggccct 660 ggccatcaac aagagctttg accagaggga cctggcacag gatgaagctg tatggctgga 720 gcgtggtccc ctggagccca gtgagccggc tgtagtggca gcagcccggg tgggcgtcgg 780 ccatgcaggg gagtgggccc ggaaacccct ccgcttctat gtccggggca gcccctgggt 840 cagtgtggtc gacagagtgg ctgagcagga cacacaggcc tgagcaaagg gcctgcccag 900 acaagatttt ttaattgttt aaaaaccgaa taaatgtttt atttctaaaa aaaaaa 956 <210> 855 <211> 1108 <212> DNA <213> Homo sapiens <400> 855 cctgggcccc catgcccgtg cagctcgcac atatgtgggg cagagcagcc accctgcccc 60 cagcagcagc cgtccatcgt cagacgtgat catttcctga ggcctcgagt gtgtcagggt 120 gtttgtgcct cataacaacc cacaggatgg tcacccccgc tttgcagatg aagaaaccaa 180 agcagttttg ccgacggatg gggcaaaaga agcagcgacc agctagagca gggcagccac 240 acagctcgtc cgacgcagcc caggcacctg cagagcagcc acacagctcg tccgatgcag 300 cccaggcacc ttgccccagg gagcgctgct tgggaccgcc caccactccg ggcccatacc 360 gcagcatcta tttctcaagc ccaaagggcc accttacccg actggggttg gagttcttcg 420 accagccggc agtccccctg gcccgggcat ttctgggaca ggtcctagtc cggcgacttc 480 ctaatggcac agaactccga ggccgcatcg tggagaccga ggcatacctg gggccagagg 540 atgaaccggc ccactcaagg ggtggccggc agaccccccg caaccgaggc atgttcatga 600 agccggggac cctgtacgtg tacatcattt acggcatgta cttctgcatg aacatctcca 660 gccaggggga cggggcttgc gtcttgctgc gagcactgga gcccctggaa ggtctggaga 720 ccatgcgtca cgttcgcagc accctccgga aaggcaccgc cagccgtgtc ctcaaggacc 780 gcgagctctg cagtggcccc tccaagctgt gccaggccct ggccatcaac aagagctttg 840 accagaggga cctggcacag gatgaagctg tatggctgga gcgtggtccc ctggagccca 900 gtgagccggc tgtagtggca gcagcccggg tgggcgtcgg ccatgcaggg gagtgggccc 960 ggaaacccct ccgcttctat gtccggggca gcccctgggt cagtgtggtc gacagagtgg 1020 ctgagcagga cacacaggcc tgagcaaagg gcctgcccag acaagatttt ttaattgttt 1080 aaaaaccgaa taaatgtttt atttctag 1108 <210> 856 <211> 775 <212> DNA <213> Homo sapiens <400> 856 ctctaaagac cgcagcatct atttctcaag cccaaagggc ctccttaccc gactggggtt 60 ggagtttttc gaccagccgg cagtccccct ggcccgggca tttctgggac aggtcctagt 120 ccggcgactt cctaatggca cagaactccg aggccgcatc gtggagaccg aggcatacct 180 ggggccagag gatgaagccg cccactcaag gggtggccgg cagacccccc gcaaccgagg 240 catgttcatg aagccgggga ccctatacgt gtacatcatt tacggcatgt acttctgcat 300 gaacatctcc agccaggggg acggggcttg cgtcttgctg cgagcactgg agcccctgga 360 aggtctggag accatgcgtc acgttcgcag caccctccgg aaaggcaccg ccagccgtgt 420 cctcaaggac cgcgagctct gcagtggccc ctccaagctg tgccaggccc tggccatcaa 480 caagagcttt gaccagaggg acctggcaca ggatgaagct gtatggctgg agcgtggtcc 540 cctggagccc agtgagccgg ctgtagtggc agcagcccgg gtgggcgtcg gccatgcagg 600 ggagtgggcc cggaaacccc tccgcttcta tgtccggggc agcccctggg tcagtgtggt 660 cgacagagtg gctgagcagg acacacaggc ctgagcaaag ggcctgccca gacaagattt 720 tttaattgtt taaaaaccga ataaatgttt tatttcaaga aaaaaaaaaa aaaaa 775 <210> 857 <211> 1051 <212> DNA <213> Homo sapiens <400> 857 aggggtgctt ccgtggtcgg cggctgctgg gctccgcgcc ggggtccgag tcccacgaag 60 ccccggcccg agccgccgga tgcccgcgcg cagcggggcc cagttttgcc gacggatggg 120 gcaaaagaag cagcgaccag ctagagcagg gcagccacac agctcgtccg acgcagccca 180 ggcacctgca gagcagccac acagctcgtc cgatgcagcc caggcacctt gccccaggga 240 gcgctgcttg ggaccgccca ccactccggg cccataccgc agcatctatt tctcaagccc 300 aaagggccac cttacccgac tggggttgga gttcttcgac cagccggcag tccccctggc 360 ccgggcattt ctgggacagg tcctagtccg gcgacttcct aatggcacag aactccgagg 420 ccgcatcgtg gagaccgagg catacctggg gccagaggat gaagccgccc actcaagggg 480 tggccggcag accccccgca accgaggcat gttcatgaag ccggggaccc tgtacgtgta 540 catcatttac ggcatgtact tctgcatgaa catctccagc cagggggacg gggcttgcgt 600 cttgctgcga gcactggagc ccctggaagg tctggagacc atgcgtcagc ttcgcagcac 660 cctccggaaa ggcaccgcca gccgtgtcct caaggaccgc gagctctgca gtggcccctc 720 caagctgtgc caggccctgg ccatcaacaa gagctttgac cagagggacc tggcacagga 780 tgaagctgta tggctggagc gtggtcccct ggagcccagt gagccggctg tagtggcagc 840 agcccgggtg ggcgtcggcc atgcagggga gtgggcccgg aaacccctcc gcttctatgt 900 ccggggcagc ccctgggtca gtgtggtcga cagagtggct gagcaggaca cacaggcctg 960 agcaaagggc ctgcccagac aagatttttt aattgtttaa aaaccgaata aatgttttat 1020 ttctagaaaa aaaaaaaaaa aaaaaaaaaa a 1051 <210> 858 <211> 759 <212> DNA <213> Homo sapiens <400> 858 ctctaaagac cgcagcatct atttctcaag cccaaagggc ctccttaccc gactggggtt 60 ggagtttttc gaccagccgg cagtccccct ggcccgggca tttctgggac aggtcctagt 120 ccggcgactt cctaatggca cagaactccg aggccgcatc gtggagaccg aggcatacct 180 ggggccagag gatgaagccg cccactcaag gggtggccgg cagacccccc gcaaccgagg 240 catgttcatg aagccgggga ccctatacgt gtacatcatt tacggcatgt acttctgcat 300 gaacatctcc agccaggggg acggggcttg cgtcttgctg cgagcactgg agcccctgga 360 aggtctggag accatgcgtc acgttcgcag caccctccgg aaaggcaccg ccagccgtgt 420 cctcaaggac cgcgagctct gcagtggccc ctccaagctg tgccaggccc tggccatcaa 480 caagagcttt gaccagaggg acctggcaca ggatgaagct gtatggctgg agcgtggtcc 540 cctggagccc agtgagccgg ctgtagtggc agcagcccgg gtgggcgtcg gccatgcagg 600 ggagtgggcc cggaaacccc tccgcttcta tgtccggggc agcccctggg tcagtgaggt 660 cgacagagtg gctgagcagg acacacaggc ctgagcaaag ggcctgccca gacaagattt 720 tttaattgtt taaaaaccga ataaatgttt tatttcaag 759 <210> 859 <211> 886 <212> DNA <213> Homo sapiens <400> 859 gcggcacgag cacacagctc gtccgacgca gcccaggcac ctgcagagcg accacacagc 60 tcgtccgatg cagcccaggc accttgcccc agggagcgct gcttgggacc gcccaccact 120 ccgggcccat accgcagcat ctatttctca agcccaaagg gccaccttac ccgactgggg 180 ttggagtttt tcgaccagcc ggcagtcccc ctggcccggg catttctggg acaggtccta 240 gtccggcgac ttcctaatgg cacagaactc cgaggccgca tcgtggagac cgaggcatac 300 ctggggccag aggatgaagc cgcccactca aggggtggcc ggcagacccc ccgcaaccga 360 ggcatgttca tgaagccggg gaccctgtac gtgtacatca tttacggcat gtacttctgc 420 atgaacatct ccagccaggg ggacggggct tgcgtcttgc tgcgagcact ggagcccctg 480 gaaggtctgg agaccatgcg tcacgttcgc agcaccctcc ggaaaggcac cgccagccgt 540 gtcctcaagg accgcgagct ctgcagtggc ccctccaagc tgtgccaggc cctggccatc 600 aacaagagct ttgaccagag ggacctggca caggatgaag ctgtatggct ggagcgtggt 660 cccctggagc ccagtgagcc ggctgtagtg gcagcagccc gggtgggcgt cggccatgca 720 ggggagtggg cccggaaacc cctccgcttc tatgtccggg gcagcccctg ggtcagtgtg 780 gtcgacagag tggctgagca ggacacacag gcctgagcaa agggcctgcc cagacaagat 840 tttttaattg tttaaaaacc gaacggcacg agctcgtgcc gaattc 886 <210> 860 <211> 2702 <212> DNA <213> Homo sapiens <400> 860 attggctctg ctggtaagtg gtctattcct gcccaccccc gggtgactag cttggccagt 60 agtcgacccc acccggggac cgactctggg ggttggagag actcttgggg ccggggtcgg 120 gcactccagc tttcttctag ccccgagctg ggattccctg gcctgcgcca gctgcgtaca 180 cggcgagtac accgcacctg cccgggactt cacccgcagc tgcgagactc ctccattccc 240 ggagggctcc ccacacctgc tgcggccgtg ccccatctcc ccgcagctgc ggcgctgagc 300 acccccatgt cgagaggctg agaccaggac agcagccctg accaacgctc caataggccg 360 ggatccagcc atacttcaat ggatcccagg ggtatcttga aggcatttcc caagcggcag 420 aaaattcatg ctgatgcatc atcaaaagta cttgcaaaga ttcctaggag ggaagaggga 480 gaagaagcag aagagtggct gagctccctt cgggcccatg ttgtgcgcac tggcattgga 540 cgagcccggg cagaactctt tgagaagcag attgttcagc atggcggcca gctatgccct 600 gcccagggcc caggtgtcac tcacattgtg gtggatgaag gcatggacta tgagcgagcc 660 ctccgccttc tcagactacc ccagctgccc ccgggtgctc agctggtgaa gtcagcctgg 720 ctgagcttgt gccttcagga gaggaggctg gtggatgtag ctggattcag catcttcatc 780 cccagtaggt acttggacca tccacagccc agcaaggcag agcaggatgc ttctattcct 840 cctggcaccc atgaggccct gcttcagaca gccctttctc ctcctcctcc tcccaccagg 900 cctgtgtctc ctccccaaaa ggcaaaagag gcaccaaaca cccaagccca gcccatctct 960 gatgatgaag ccagtgatgg ggaagaaacc caggttagtg cagctgatct ggaagccctc 1020 atcagtggcc actaccccac ctcccttgag ggagattgtg agcctagccc agcccctgct 1080 gtcctggata agtgggtctg tgcacagccc tcaagccaga aggcgaccaa tcacaacctc 1140 catatcacag agaagctgga agttctggcc aaagcctaca gtgttcaggg agacaagtgg 1200 agggccctgg gctatgccaa ggccatcaat gccctcaaga gcttccataa gcctgtcacc 1260 tcgtaccagg aggcctgcag tatccctggg attgggaagc ggatggctga gaaaatcata 1320 gagatcctgg agagcgggca tttgcggaag ctggaccata tcagtgagag cgtgcctgtc 1380 ttggagctct tctccaacat ctggggagct gggaccaaga ctgcccagat gtggtaccaa 1440 cagggcttcc gaagtctgga agacatccgc agccaggcct ccctgacaac ccagcaggcc 1500 atcggcctga agcattacag tgacttcctg gaacgtatgc ccagggagga ggctacagag 1560 attgagcaga cagtccagaa agcagcccag gcctttaact ctgggctgct gtgtgtggca 1620 tgtggttcat accgacgggg aaaggcgacc tgtggtgatg tcgacgtgct catcactcac 1680 ccagatggcc ggtcccaccg gggtatcttc agccgcctcc ttgacagtct tcggcaggaa 1740 gggttcctca cagatgactt ggtgagccaa gaggagaatg gtcagcaaca gaagtacttg 1800 ggggtgtgcc ggctcccagg gccagggcgg cggcaccggc gcctggacat catcgtggtg 1860 ccctatagcg agtttgcctg tgccctgctc tacttcaccg gctctgcaca cttcaaccgc 1920 tccatgcgag ccctggccaa aaccaagggc atgagtctgt cagaacatgc cctcagcact 1980 gctgtggtcc ggaacaccca tggctgcaag gtggggcctg gccgagtgct gcccactccc 2040 actgagaagg atgtcttcag gctcttaggc ctcccctacc gagaacctgc tgagcgggac 2100 tggtgaccca tggctggggg tgctgaggag agccgagttg gactggctac ccctcctggc 2160 cacccagtac tccctccagc ctcagctggc tgaacctcgc cgctccaacc accagcttcc 2220 tcagcgagca gggcccaggg ctctgggcct gaagcaagag ccagcccggc tcccagtgtc 2280 tgcccggctc ccagtgtctg cccagccctc tcccagacag gagcaggctg ccaccccttc 2340 tacctcacca ctgcccctcg aagaattttg caaatggccc cttgccccat tttaagcagg 2400 agcaggtggc tggtttgaag ccccaggtat cccccttccc tgctatggga aaggccaagc 2460 tgctgggtgg ggacagaagc tgcaggggag agggaagcag ccgtgctgtc aacatcatcc 2520 ggcaccctct ggggtaggag aacagccatt ccacatgtgt tccctctatc cgtcctgctt 2580 cctgggcagc tggtggtgct gggaatgggg tgccccagcc ttggtgagga cagtgttggg 2640 aggcccaggg gcccagtaaa gtgcatttga cattgaaaaa aaaaaaaaaa aaaaaaaaaa 2700 aa 2702 <210> 861 <211> 4128 <212> DNA <213> Homo sapiens <400> 861 cttgcaaaga ttcctaggag ggaagaggga gaagaagcag aaggtccaga aagcagccca 60 ggcctttaac tctgggctgc tgtgtgtggc atgtggttca taccgacggg gaaaggcgac 120 ctgtggtgat gtcgacgtgc tcatcactca cccagatggc cggtcccacc ggggtatctt 180 cagccgcctc cttgacagtc ttcggcagga aggtataagc tccatctctg ggtgagcagg 240 ttgacagagg gcagcacagg tctgggggcc ccctcagagg gagaacctca gaagttccag 300 tcctgaggca ggaagcaggg gaacagtgct ttgccagcat cccatctctc tatcggggcc 360 ggaatcctct ccagggagag atggaacagc cccgccacac ctatgtggag gtgctcagtg 420 aaccctgcag gccaagtatc tcatctgatc tttctgtgac actatggggg agatgggaat 480 tactatccat gttttacaga aaaggagaag ggcccagaga gggtagtgtc acccagctaa 540 tacctgggca agccccagct tagacatcag gagagacctg ggaggatggg acagcccagg 600 cctggttccc tgccctccca gcagtcccct ctgttgggcc agggttcctc acagatgact 660 tggtgagcca agaggagaat ggtcagcaac agaagtactt gggggtgtgc cggctcccag 720 ggccagggcg gcggcaccgg cgcctggaca tcatcgtggt gccctatagc gagtttgcct 780 gtgccctgct ctacttcacc ggctctgcac acttcaaccg ctccatgcga gccctggcca 840 aaactaaggg catgagtctg tcagaacatg ccctcagcac tgctgtggtc cggaacaccc 900 atggctgcaa ggtggggcct ggccgagtgc tgcccactcc cactgagaag gatgtcttca 960 ggctcttagg cctcccctac cgagaacctg ctgagcggga ctggtgaccc atggctgggg 1020 gtgctgagga gagccgagtt ggactggcta cccctcctgg ccacccagta ctccctccag 1080 cctcagctgg ctgaacctcg ccgctccaac caccagcttc ctcagcgagc agggcccagg 1140 gctctgggcc tgaagcaaga gccagcccgg ctcccagtgt ctgcccggct cccagtgtct 1200 gcccagccct ctcccagaca ggagcaggct gccacccctt ctacctcacc actgcccctc 1260 gaagaatttt gcaaatggcc ccttgcccca ttttaagcag gagcaggtgg ctggtttgaa 1320 gccccaggta tcccccttcc ctgctatggg aaaggccaag ctgctgggtg gggacagaag 1380 ctgcagggga gagggaagca gccgtgctgt caacatcatc cggcaccctc tggggtagga 1440 gaacagccat tccacatgtg ttccctctat ccgtcctgct tcctgggcag ctggtggtgc 1500 tgggaatggg gtgccccagc cttggtgagg acagtgttgg gaggcccagg ggcccagtaa 1560 agtgcatttg acattgaacc tgcctggtgt ctgagctgct gcagcctctg gctaccttgt 1620 tccacccagg cagggacgac agagatggga actgaaaaga ggagcccaga aaggctgtgt 1680 taactgccct ccagacagga ctggcctgag tcagctccta aactcacagc aaggacagca 1740 gtggctgtga ccagggagaa tgttggagcc aggcacccag agctcctatc tagtcatcag 1800 catcttctgc aggccctacc ttagaccagg ctatcagggg acatgagcaa aagtgacaag 1860 actcaggaaa ccattaggaa caactaaatg gtgaccgtgt acacagggat gggcggccag 1920 ggaaggcttc ccggaggagg agagaggcag actggcaggg aaattgcctc tgagaggagt 1980 cagcaggctc tgtttgggga caattaagga acagctttag agaggacact gtgtgctggg 2040 agtcaggagc aggctgggct ggcagaggac tggaagcaga gcttggtttg atagagcaga 2100 caggagcagg tcccgctggg gagtgcggga tgtcttcctg aggctgtttc acagggcagg 2160 gagacttggt gggggagtgg ggtcatggaa ggagcttcag gcagcccaag tatgaggagg 2220 agtgggcaca gagtcagaag gagactgtat tggaggagga gcctggagag gccccatgct 2280 gggagttggg tggtgacgcg tgagggcagc tttggctcca cagggggatc ccaccttgag 2340 tgtgctgggt gggctacatt tctgttggta acttgcagag tcccggagcc agcctttgtc 2400 tgcctggtct cgatcatggg atcctagcag cctgggagta ggccccccaa ctcaagctca 2460 tacccctgaa gtgtaagtca gggggtcttc ccagcactga tcatgttggg aaaggaatca 2520 gaagcccaca ggacctggag ggccctttcg cagctcagca ccaacccaag agatggccaa 2580 tcaaaagccc agaagccttc tagaggggcg agcctctccc ctgagagtgt ctactgccag 2640 ggacacatgg ctgccaagag ccacagtggg ggcctgggta gataggagag gggctgggga 2700 aagcctgggc ccccgggtgt gaaggcttgc tttcggtccc actctggact ggtccctcag 2760 tgcctgctgc tgtccccagc aagagttgga gtcagcagaa gtccaaagat gcgtgtctgg 2820 gtccaaatgt ggaagttgct tctctccttt tgccgcagcc tgctccaggc ccaaggaaca 2880 ggacctccag ggctgggggt ggagggaacc agtgtgcagc aggccataga gtagctcgcc 2940 caagttttcc tacacacagg gaggtcccag aactgcaggg agggatgccg cttacttctt 3000 tgtctgaaat cagggtctga cctccattct tgacatccct ccccatctgc cttaactcct 3060 tcccccagga gactcagaat tcagagactg ccttgaaacc atgcagactc ttggtcccac 3120 ctcctggcca gggcaacaca aagtcgtggg ataaagaggg agcatgcccc acctccagtg 3180 acccatctgg gtgtcccttc agctgcccag tctgacacag aagcccagga gaagagccac 3240 tgaggcagag gagctaatgg agggatttct gagtcttgag aaaggctgcc cagtttggag 3300 gtaaaatgag gtgaaatgag gttctctgag tccaagtaag caaggaatat gaatattggg 3360 ggttcccagg cactttagcg ctgaaccagg ttctcgaaca ggctttcagc ccagtctccc 3420 attcatcctg aatggagaga gactccattt cagggccctg gtggtaactg gggtcctgtc 3480 cagcagctga gcaccccgca cacctaccac ccagtcacca cctggcctgg agtgggcaga 3540 gagaccccac aagtctgctc cctgctccag cccagttctt catcactctg tccctgagcc 3600 agggttgtcc ttggacaggc cacgtgtggc aggcagaata atggtccact gaagatgtcc 3660 atgtcttaat ccctggaacc tgtgaatatg tcaccttagt tggctagagg gactttgcag 3720 ttgtgatgaa gcttaagcat tttgagatga ggtgattatg ctgagtaatc ctgtgggccc 3780 agtgtaaaca tgagttctta agagctacag tcagggccgg gtgtggtggc tgacgcctgt 3840 aatcccaaca ctttgcgagg ccaaggcggg ttgattgctt gagcctggga gtttgagacc 3900 agcctggtca acatggcaaa accccatctc taccaaaaaa aaaaaaaaaa aaaattcaaa 3960 agttagctag gcatggccag acctagtggt gcctataatc ccagctactt gggaggctga 4020 agtgggagga tcacctgagc ctgggaggca gaggtgcaga ggttccaatg agctgagatt 4080 acaccactgc actccagcct gagttgtaac agagtgagac cctgtctc 4128 <210> 862 <211> 2064 <212> DNA <213> Homo sapiens <400> 862 ttatttattt attcatttat ttagcagaga tggtgttttg ccgtgttacc caggctggtc 60 ttgaactcct gggctcaagc aatctaccct cggctcagcc ctgcaaagtg ctgggattac 120 agccatgagc ccttgtgtcc cgcctaaaaa gttgtttaaa agaagtttgg actctgaagc 180 ctaacagacc agggtttgaa ctctggttcc tgtcattcac taactgtgtg actccagaca 240 agttacttaa actctcaaag catcagtttt ctcattagta aaaaggggct actattaaat 300 gaaatggtcc ctgtagcaca ggacctgaca tagagtaagc cctcagtaaa tgttagctct 360 tgctgttgga atgatgatga tggtggtggt ggtggtggtg actaatatca tcattatttt 420 ctacttctta ctgctggtct ccatccttct gggaaccaaa agacaaatta cccagccctc 480 attctatcca aaattctcat cttcaactac acccaagctt tacacagcca cacagttgcc 540 aagcagccag gctggctttt atgccagcat ctgctagagg agtcagcttc ctttccactg 600 gctctacctc ttccatctcc tcactcttct ttcttgcctc tgcctcctcc tcctctagga 660 ggcctgcagt atccctggga ttgggaagcg gatggctgag aaaatcatag agatcctgga 720 gagcgggcat ttgcggaagc tggaccatat cagtgagagc gtgcctgtct tggagctctt 780 ctccaacatc tggggagctg ggaccaagac tgcccagatg tggtaccaac agggcttccg 840 aagtctggaa gacatccgca gccaggcctc cctgacaacc cagcaggcca ttggcctgaa 900 gcattacagt gacttcctgg aacgtatgcc cagggaggag gctacagaga ttgagcagac 960 agtccagaaa gcagcccagg cctttaactc cgggctgctg tgtgtggcat gtggttcata 1020 ccgacgggga aaggcgacct gtggtgatgt cgacgtgctc atcactcacc cagatggctg 1080 gtcccaccgg ggtatcttca gccgcctcct tgacagtctt cggcaggaag ggttcctcac 1140 agatgacttg gtgagccaag aggagaatgg tcagcaacag aagtacttgg gggtgtgccg 1200 gctcccaggg ccagggcggc ggcaccggcg cctggacatc atcgtggtgc cctatagcga 1260 gtttgcctgt gccctgctct acttcaccgg ctctgcacac ttcaaccgct ccatgcgagc 1320 cctggccaaa accaagggca tgagtctgtc agaacatgcc ctcagcactg ctgtggtccg 1380 gaacacccat ggctgcaagg tggggcctgg ccgagtgctg cccactccca ctgagaagga 1440 tgtcttcagg ctcttaggcc tcccctaccg agaacctgct gagcgggact ggtgacccat 1500 ggctgggggt gctgaggaga gccgagttgg actggctacc cctcctggcc acccagtact 1560 ccctccagcc tcagctggct gaacctcgcc gctccaacca ccagcttcct cagcgagcag 1620 ggcccagggc tctgggcctg aagcaagagc cagcccggct cccagtgtct gcccggctcc 1680 cagtgtctgc ccagccctct cccagacagg agcaggctgc caccccttct acctcaccac 1740 tgcccctcga agaattttgc aaatggcccc ttgccccatt ttaagcagga gcaggtggct 1800 ggtttgaagc cccaggtatc ccccttccct gctatgggaa aggccaagct gctgggtggg 1860 gacagaagct gcaggggaga gggaagcagc cgtgctgtca acatcatccg gcaccctctg 1920 gggtaggaga acagccattc cacatgtgtt ccctctatcc gtcctgcttc ccggtcagct 1980 ggtggtgctg ggaatggggt gccccagcct tggtgaggac agtgttggga ggcccagggg 2040 cccagtaaag tgcatttgac attg 2064 <210> 863 <211> 2696 <212> DNA <213> Homo sapiens <400> 863 agtagtcgac cccacccggg gaccgactct gggggttgga gagactcttg gggccggggt 60 cgggcactcc agctttcttc tagccccgag ctgggattcc ctggcctgcg ccagctgcgt 120 acacggcgag tacaccgcac ctgcccggga cttcacccgc agctgcgaga ctcctccatt 180 cccggagggc tccccacacc tgctgcggcc gtgccccatc tccccgcagc tgcggcgctg 240 agcaccccca tgtcgagagg ctgagaccag gacaggtgca gggcgttccc actcaccccc 300 gaaagtcctc ctccttcctc tgcgagtctg tgttggagca gccctgacca acgctccaat 360 aggccgggat ccagccatac ttcaatggat cccaggggta tcttgaaggc atttcccaag 420 cggcagaaaa ttcatgctga tgcatcatca aaagtacttg caaagattcc taggagggaa 480 gagggagaag aagcagaaga gtggctgagc tcccttcggg cccatgttgt gcgcactggc 540 attggacgag cccgggcaga actctttgag aagcagattg ttcagcatgg cggccagcta 600 tgccctgccc agggcccagg tgtcactcac attgtggtgg atgaaggcat ggactatgag 660 cgagccctcc gccttctcag actaccccag ctgcccccgg gtgctcagct ggtgaagtca 720 gcctggctga gcttgtgcct tcaggagagg aggctggtgg atgtagctgg attcagcatc 780 ttcatcccca gtaggtactt ggaccatcca cagcccagca aggcagagca ggatgcttct 840 attcctcctg gcacccatga ggccctgctt cagacagccc tttctcctcc tcctcctccc 900 accaggcctg tgtctcctcc ccaaaaggca aaagaggcac caaacaccca agcccagccc 960 atctctgatg atgaagccag tgatggggaa gaaacccagg ttagtgcagc tgatctggaa 1020 gccctcatca gtggccacta ccccacctcc cttgagggag attgtgagcc tagcccagcc 1080 cctgctgtcc tggataagtg ggtctgtgca cagccctcaa gccagaaggc gaccaatcac 1140 aacctccata tcacagagaa gctggaagtt ctggccaaag cctacagtgt tcagggagac 1200 aagtggaggg ccctgggcta tgccaaggcc atcaatgccc tcaagagctt ccataagcct 1260 gtcacctcgt accagggggc ctgcagtatc cctgggattg ggaagcggat ggctgagaaa 1320 atcatagaga tcctggagag cgggcatttg cggaagctgg accatatcag tgagagcgtg 1380 cctgtcttgg agctcttctc caacatctgg ggagctggga ccaagactgc ccagatgtgg 1440 taccaacagg gcttccgaag tctggaagac atccgcagcc aggcctccct gacaacccag 1500 caggccatcg gcctgaagca ttacagtgac ttcctggaac gtatgcccag ggaggaggct 1560 acagagattg agcagacagt ccagaaagca gcccaggcct ttaactctgg gctgctgtgt 1620 gtggcatgtg gttcataccg acggggaaag gcgacctgtg gtgatgtcga cgtgctcatc 1680 actcacccag atggccggtc ccaccggggt atcttcagcc gcctccttga cagtcttcgg 1740 caggaagggt tcctcacaga tgacttggtg agccaagagg agaatggtca gcaacagaag 1800 tacttggggg tgtgccggct cccagggcca gggcggcggc accggcgcct ggacatcatc 1860 gtggtgccct atagcgagtt tgcctgtgcc ctgctctact tcaccggctc tgcacacttc 1920 aaccgctcca tgcgagccct ggccaaaacc aagggcatga gtctgtcaga acatgccctc 1980 agcactgctg tggtccggaa cacccatggc tgcaaggtgg ggcctggccg agtgctgccc 2040 actcccactg agaaggatgt cttcaggctc ttaggcctcc cctaccgaga acctgctgag 2100 cgggactggt gacccatggc tgggggtgct gaggagagcc gagttggact ggctacccct 2160 cctggccacc cagtactccc tccagcctca gctggctgaa cctcgccgct ccaaccacca 2220 gcttcctcag cgagcagggc ccagggctct gggcctgaag caagagccag cccggctccc 2280 agtgtctgcc cggctcccag tgtctgccca gccctctccc agacaggagc aggctgccac 2340 cccttctacc tcaccactgc ccctcgaaga attttgcaaa tggccccttg ccccatttta 2400 agcaggagca ggtggctggt ttgaagcccc aggtatcccc cttccctgct atgggaaagg 2460 ccaagctgct gggtggggac agaagctgca ggggagaggg aagcagccgt gctgtcaaca 2520 tcatccggca ccctctgggg taggagaaca gccattccac atgtgttccc tctatccgtc 2580 ctgcttcctg ggcagctggt ggtgctggga atggggtgcc ccagccttgg tgaggacagt 2640 gttgggaggc ccaggggccc agtaaagtgc atttgacatt gaaaaaaaaa aaaaaa 2696 <210> 864 <211> 2678 <212> DNA <213> Homo sapiens <400> 864 ctgctggtaa gtggtctatt cctgcccacc cccgggtgac tagcttggcc agtagtcgac 60 cccacccggg gaccgactct gggggttgga gagactcttg gggccggggt cgggcactcc 120 agctttcttc tagccccgag ctgggattcc ctggcctgcg ccagctgcgt acacggcgag 180 tacaccgcac ctgcccggga cttcacccgc agctgcgaga ctcctccatt cccggagggc 240 tccccacacc tgctgcggcc gtgccccatc tccccgcagc tgcggcgctg agcaccccca 300 tgtcgagagg ctgagaccag gacagcagcc ctgaccaacg ctccaatagg ccgggatcca 360 gccatacttc aatggatccc aggggtatct tgaaggcatt tcccaagcgg cagaaaattc 420 atgctgatgc atcatcaaaa gtacttgcaa agattcctag gagggaagag ggagaagaag 480 cagaagagtg gctgagctcc cttcgggccc atgttgtgcg cactggcatt ggacgagccc 540 gggcagaact ctttgagaag cagattgttc agcatggcgg ccagctatgc cctgcccagg 600 gcccaggtgt cactcacatt gtggtggatg aaggcatgga ctatgagcga gccctccgcc 660 ttctcagact accccagctg cccccgggtg ctcagctggt gaagtcagcc tggctgagct 720 tgtgccttca ggagaggagg ctggtggatg tagctggatt cagcatcttc atccccagta 780 ggtacttgga ccatccacag cccagcaagg cagagcagga tgcttctatt cctcctggca 840 cccatgaggc cctgcttcag acagcccttt ctcctcctcc tcctcccacc aggcctgtgt 900 ctcctcccca aaaggcaaaa gaggcaccaa acacccaagc ccagcccatc tctgatgatg 960 aagccagtga tggggaagaa acccaggtta gtgcagctga tctggaagcc ctcatcagtg 1020 gccactaccc cacctccctt gagggagatt gtgagcctag cccagcccct gctgtcctgg 1080 ataagtgggt ctgtgcacag ccctcaagcc agaaggcgac caatcacaac ctccatatca 1140 cagagaagct ggaagttctg gccaaagcct acagtgttca gggagacaag tggagggccc 1200 tgggctatgc caaggccatc aatgccctca agagcttcca taagcctgtc acctcgtacc 1260 aggaggcctg cagtatccct gggattggga agcggatggc tgagaaaatc atagagatcc 1320 tggagagcgg gcatttgcgg aagctggacc atatcagtga gagcgtgcct gtcttggagc 1380 tcttctccaa catctgggga gctgggacca agactgccca gatgtggtac caacagggct 1440 tccgaagtct ggaagacatc cgcagccagg cctccctgac aacccagcag gccatcggcc 1500 tgaagcatta cagtgacttc ctggaacgta tgcccaggga ggaggctaca gagattgagc 1560 agacagtcca gaaagcagcc caggccttta actctgggct gctgtgtgtg gcatgtggtt 1620 cataccgacg gggaaaggcg acctgtggtg atgtcgacgt gctcatcact cacccagatg 1680 gccggtccca ccggggtatc ttcagccgcc tccttgacag tcttcggcag gaagggttcc 1740 tcacagatga cttggtgagc caagaggaga atggtcagca acagaagtac ttgggggtgt 1800 gccggctccc agggccaggg cggcggcacc ggcgcctgga catcatcgtg gtgccctata 1860 gcgagtttgc ctgtgccctg ctctacttca ccggctctgc acacttcaac cgctccatgc 1920 gagccctggc caaaaccaag ggcatgagtc tgtcagaaca tgccctcagc actgctgtgg 1980 tccggaacac ccatggctgc aaggtggggc ctggccgagt gctgcccact cccactgaga 2040 aggatgtctt caggctctta ggcctcccct accgagaacc tgctgagcgg gactggtgac 2100 ccatggctgg gggtgctgag gagagccgag ttggactggc tacccctcct ggccacccag 2160 tactccctcc agcctcagct ggctgaacct cgccgctcca accaccagct tcctcagcga 2220 gcagggccca gggctctggg cctgaagcaa gagccagccc ggctcccagt gtctgcccgg 2280 ctcccagtgt ctgcccagcc ctctcccaga caggagcagg ctgccacccc ttctacctca 2340 ccactgcccc tcgaagaatt ttgcaaatgg ccccttgccc cattttaagc aggagcaggt 2400 ggctggtttg aagccccagg tatccccctt ccctgctatg ggaaaggcca agctgctggg 2460 tggggacaga agctgcaggg gagagggaag cagccgtgct gtcaacatca tccggcaccc 2520 tctggggtag gagaacagcc attccacatg tgttccctct atccgtcctg cttcctgggc 2580 agctggtggt gctgggaatg gggtgcccca gccttggtga ggacagtgtt gggaggccca 2640 ggggcccagt aaagtgcatt tgacattgaa aaaaaaaa 2678 <210> 865 <211> 2338 <212> DNA <213> Homo sapiens <400> 865 gggcctcaat tctggatttc cacgtgcagc agccctgacc aacgctccaa taggccggga 60 tccagccata cttcaatgga tcccaggggt atcttgaagg catttcccaa gcggcagaaa 120 attcatgctg atgcatcatc aaaagtactt gcaaagattc ctaggaggga agagggagaa 180 gaagcagaag agtggctgag ctcccttcgg gcccatgttg tgcgcactgg cattggacga 240 gcccgggcag aactctttga gaagcagatt gttcagcatg gcggccagct atgccctgcc 300 cagggcccag gtgtcactca cattgtggtg gatgaaggca tggactatga gcgagccctc 360 cgccttctca gactacccca gctgcccccg ggtgctcagc tggtgaagtc agcctggctg 420 agcttgtgcc ttcaggagag gaggctggtg gatgtagctg gattcagcat cttcatcccc 480 agtaggtact tggaccatcc acagcccagc aaggcagagc aggatgcttc tattcctcct 540 ggcacccatg aggccctgct tcagacagcc ctttctcctc ctcctcctcc caccaggcct 600 gtgtctcctc cccaaaaggc aaaagaggca ccaaacaccc aagcccagcc catctctgat 660 gatgaagcca gtgatgggga agaaacccag gttagtgcag ctgatctgga agccctcatc 720 agtggccact accccacctc ccttgaggga gattgtgagc ctagcccagc ccctgctgtc 780 ctggataagt gggtctgtgc acagccctca agccagaagg cgaccaatca caacctccat 840 atcacagaga agctggaagt tctggccaaa gcctacagtg ttcagggaga caagtggagg 900 gccctgggct atgccaaggc catcaatgcc ctcaagagct tccataagcc tgtcacctcg 960 taccaggagg cctgcagtat ccctgggatt gggaagcgga tggctgagaa aatcatagag 1020 atcctggaga gcgggcattt gcggaagctg gaccatatca gtgagagcgt gcctgtcttg 1080 gagctcttct ccaacatctg gggagctggg accaagactg cccagatgtg gtaccaacag 1140 ggcttccgaa gtctggaaga catccgcagc caggcctccc tgacaaccca gcaggccatc 1200 ggcctgaagc attacagtga cttcctggaa cgtatgccca gggaggaggc tacagagatt 1260 gagcagacag tccagaaagc agcccaggcc tttaactctg ggctgctgtg tgtggcatgt 1320 ggttcatacc gacggggaaa ggcgacctgt ggtgatgtcg acgtgctcat cactcaccca 1380 gatggccggt cccaccgggg tatcttcagc cgcctccttg acagtcttcg gcaggaaggg 1440 ttcctcacag atgacttggt gagccaagag gagaatggtc agcaacagaa gtacttgggg 1500 gtgtgccggc tcccagggcc agggcggcgg caccggcgcc tggacatcat cgtggtgccc 1560 tatagcgagt ttgcctgtgc cctgctctac ttcaccggct ctgcacactt caaccgctcc 1620 atgcgagccc tggccaaaac caagggcatg agtctgtcag aacatgccct cagcactgct 1680 gtggtccgga acacccatgg ctgcaaggtg gggcctggcc gagtgctgcc cactcccact 1740 gagaaggatg tcttcaggct cttaggcctc ccctaccgag aacctgctga gcgggactgg 1800 tgacccatgg ctgggggtgc tgaggagagc cgagttggac tggctacccc tcctggccac 1860 ccagtactcc ctccagcctc agctggctga acctcgccgc tccaaccacc agcttcctca 1920 gcgagcaggg cccagggctc tgggcctgaa gcaagagcca gcccggctcc cagtgtctgc 1980 ccggctccca gtgtctgccc agccctctcc cagacaggag caggctgcca ccccttctac 2040 ctcaccactg cccctcgaag aattttgcaa atggcccctt gccccatttt aagcaggagc 2100 aggtggctgg tttgaagccc caggtatccc ccttccctgc tatgggaaag gccaagctgc 2160 tgggtgggga cagaagctgc aggggagagg gaagcagccg tgctgtcaac atcatccggc 2220 accctctggg gtaggagaac agccattcca catgtgttcc ctctatccgt cctgcttcct 2280 gggcagctgg tggtgctggg aatggggtgc cccagccttg gtgaggacag tgttggga 2338 <210> 866 <211> 1848 <212> DNA <213> Homo sapiens <400> 866 ccgggtgact agcttggcca gtagtcgacc ccacccgggg accgactctg ggggttggag 60 agactcttgg ggccggggtc gggcactcca gctttcttct agccccgagc tgggattccc 120 tggcctgcgc cagctgcgta cacggcgagt acaccgcacc tgcccgggac ttcacccgca 180 gctgcgagac tcctccattc ccggagggct ccccacacct gctgcggccg tgccccatct 240 ccccgcagct gcggcgctga gcacccccat gtcgagaggc tgagaccagg acagcagccc 300 tgaccaacgc tccaataggc cgggatccag ccatacttca atggatccca ggggtatctt 360 gaaggcattt cccaagcggc agaaaattca tgctgatgca tcatcaaaag tacttgcaaa 420 gattcctagg agggaagagg gagaagaagc agaagcccat ctctgatgat gaagccagtg 480 atggggaaga aacccaggag gcctgcagta tccctgggat tgggaagcgg atggctgaga 540 aaatcataga gatcctggag agcgggcatt tgcggaagct ggaccatatc agtgagagcg 600 tgcctgtctt ggagctcttc tccaacatct ggggagctgg gaccaagact gcccagatgt 660 ggtaccaaca gggcttccga agtctggaag acatccgcag ccaggcctcc ctgacaaccc 720 agcaggccat cggcctgaag cattacagtg acttcctgga acgtatgccc agggaggagg 780 ctacagagat tgagcagaca gtccagaaag cagcccaggc ctttaactct gggctgctgt 840 gtgtggcatg tggttcatac cgacggggaa aggcgacctg tggtgatgtc gacgtgctca 900 tcactcaccc agatggccgg tcccaccggg gtatcttcag ccgcctcctt gacagtcttc 960 ggcaggaagg gttcctcaca gatgacttgg tgagccaaga ggagaatggt cagcaacaga 1020 agtacttggg ggtgtgccgg ctcccagggc cagggcggcg gcaccggcgc ctggacatca 1080 tcgtggtgcc ctatagcgag tttgcctgtg ccctgctcta cttcaccggc tctgcacact 1140 tcaaccgctc catgcgagcc ctggccaaaa ccaagggcat gagtctgtca gaacatgccc 1200 tcagcactgc tgtggtccgg aacacccatg gctgcaaggt ggggcctggc cgagtgctgc 1260 ccactcccac tgagaaggat gtcttcaggc tcttaggcct cccctaccga gaacctgctg 1320 agcgggactg gtgacccatg gctgggggtg ctgaggagag ccgagttgga ctggctaccc 1380 ctcctggcca cccagtactc cctccagcct cagctggctg aacctcgccg ctccaaccac 1440 cagcttcctc agcgagcagg gcccagggct ctgggcctga agcaagagcc agcccggctc 1500 ccagtgtctg cccggctccc agtgtctgcc cagccctctc ccagacagga gcaggctgcc 1560 accccttcta cctcaccact gcccctcgaa gaattttgca aatggcccct tgccccattt 1620 taagcaggag caggtggctg gtttgaagcc ccaggtatcc cccttccctg ctatgggaaa 1680 ggccaagctg ctgggtgggg acagaagctg caggggagag ggaagcagcc gtgctgtcaa 1740 catcatccgg caccctctgg ggtaggagaa cagccattcc acatgtgttc cctctatccg 1800 tcctgcttcc tgggcagctg gtggtgctgg gaatggggtg ccccagcc 1848 <210> 867 <211> 2702 <212> DNA <213> Homo sapiens <400> 867 attggctctg ctggtaagtg gtctattcct gcccaccccc gggtgactag cttggccagt 60 agtcgacccc acccggggac cgactctggg ggttggagag actcttgggg ccggggtcgg 120 gcactccagc tttcttctag ccccgagctg ggattccctg gcctgcgcca gctgcgtaca 180 cggcgagtac accgcacctg cccgggactt cacccgcagc tgcgagactc ctccattccc 240 ggagggctcc ccacacctgc tgcggccgtg ccccatctcc ccgcagctgc ggcgctgagc 300 acccccatgt cgagaggctg agaccaggac agcagccctg accaacgctc caataggccg 360 ggatccagcc atacttcaat ggatcccagg ggtatcttga aggcatttcc caagcggcag 420 aaaattcatg ctgatgcatc atcaaaagta cttgcaaaga ttcctaggag ggaagaggga 480 gaagaagcag aagagtggct gagctccctt cgggcccatg ttgtgcgcac tggcattgga 540 cgagcccggg cagaactctt tgagaagcag attgttcagc atggcggcca gctatgccct 600 gcccagggcc caggtgtcac tcacattgtg gtggatgaag gcatggacta tgagcgagcc 660 ctccgccttc tcagactacc ccagctgccc ccgggtgctc agctggtgaa gtcagcctgg 720 ctgagcttgt gccttcagga gaggaggctg gtggatgtag ctggattcag catcttcatc 780 cccagtaggt acttggacca tccacagccc agcaaggcag agcaggatgc ttctattcct 840 cctggcaccc atgaggccct gcttcagaca gccctttctc ctcctcctcc tcccaccagg 900 cctgtgtctc ctccccaaaa ggcaaaagag gcaccaaaca cccaagccca gcccatctct 960 gatgatgaag ccagtgatgg ggaagaaacc caggttagtg cagctgatct ggaagccctc 1020 atcagtggcc actaccccac ctcccttgag ggagattgtg agcctagccc agcccctgct 1080 gtcctggata agtgggtctg tgcacagccc tcaagccaga aggcgaccaa tcacaacctc 1140 catatcacag agaagctgga agttctggcc aaagcctaca gtgttcaggg agacaagtgg 1200 agggccctgg gctatgccaa ggccatcaat gccctcaaga gcttccataa gcctgtcacc 1260 tcgtaccagg aggcctgcag tatccctggg attgggaagc ggatggctga gaaaatcata 1320 gagatcctgg agagcgggca tttgcggaag ctggaccata tcagtgagag cgtgcctgtc 1380 ttggagctct tctccaacat ctggggagct gggaccaaga ctgcccagat gtggtaccaa 1440 cagggcttcc gaagtctgga agacatccgc agccaggcct ccctgacaac ccagcaggcc 1500 atcggcctga agcattacag tgacttcctg gaacgtatgc ccagggagga ggctacagag 1560 attgagcaga cagtccagaa agcagcccag gcctttaact ctgggctgct gtgtgtggca 1620 tgtggttcat accgacgggg aaaggcgacc tgtggtgatg tcgacgtgct catcactcac 1680 ccagatggcc ggtcccaccg gggtatcttc agccgcctcc ttgacagtct tcggcaggaa 1740 gggttcctca cagatgactt ggtgagccaa gaggagaatg gtcagcaaca gaagtacttg 1800 ggggtgtgcc ggctcccagg gccagggcgg cggcaccggc gcctggacat catcgtggtg 1860 ccctatagcg agtttgcctg tgccctgctc tacttcaccg gctctgcaca cttcaaccgc 1920 tccatgcgag ccctggccaa aaccaagggc atgagtctgt cagaacatgc cctcagcact 1980 gctgtggtcc ggaacaccca tggctgcaag gtggggcctg gccgagtgct gcccactccc 2040 actgagaagg atgtcttcag gctcttaggc ctcccctacc gagaacctgc tgagcgggac 2100 tggtgaccca tggctggggg tgctgaggag agccgagttg gactggctac ccctcctggc 2160 cacccagtac tccctccagc ctcagctggc tgaacctcgc cgctccaacc accagcttcc 2220 tcagcgagca gggcccaggg ctctgggcct gaagcaagag ccagcccggc tcccagtgtc 2280 tgcccggctc ccagtgtctg cccagccctc tcccagacag gagcaggctg ccaccccttc 2340 tacctcacca ctgcccctcg aagaattttg caaatggccc cttgccccat tttaagcagg 2400 agcaggtggc tggtttgaag ccccaggtat cccccttccc tgctatggga aaggccaagc 2460 tgctgggtgg ggacagaagc tgcaggggag agggaagcag ccgtgctgtc aacatcatcc 2520 ggcaccctct ggggtaggag aacagccatt ccacatgtgt tccctctatc cgtcctgctt 2580 cctgggcagc tggtggtgct gggaatgggg tgccccagcc ttggtgagga cagtgttggg 2640 aggcccaggg gcccagtaaa gtgcatttga cattgaaaaa aaaaaaaaaa aaaaaaaaaa 2700 aa 2702 <210> 868 <211> 2368 <212> DNA <213> Homo sapiens <400> 868 gatttccacg tgcagcagcc ctgaccaacg ctccaatagg ccgggatcca gccatacttc 60 aatggatccc aggggtatct tgaaggcatt tcccaagcgg cagaaaattc atgctgatgc 120 atcatcaaaa gtacttgcaa agattcctag gagggaagag ggagaagaag cagaagagtg 180 gctgagctcc cttcgggccc atgttgtgcg cactggcatt ggacgagccc gggcagaact 240 ctttgagaag cagattgttc agcatggcgg ccagctatgc cctgcccagg gcccaggtgt 300 cactcacatt gtggtggatg aaggcatgga ctatgagcga gccctccgcc ttctcagact 360 accccagctg cccccgggtg ctcagctggt gaagtcagcc tggctgagct tgtgccttca 420 ggagaggagg ctggtggatg tagctggatt cagcatcttc atccccagta ggtacttgga 480 ccatccacag cccagcaagg cagagcagga tgcttctatt cctcctggca cccatgaggc 540 cctgcttcag acagcccttt ctcctcctcc tcctcccacc aggcctgtgt ctcctcccca 600 aaaggcaaaa gaggcaccaa acacccaagc ccagcccatc tctgatgatg aagccagtga 660 tggggaagaa acccaggtta gtgcagctga tctggaagcc ctcatcagtg gccactaccc 720 cacctccctt gagggagatt gtgagcctag cccagcccct gctgtcctgg ataagtgggt 780 ctgtgcacag ccctcaagcc agaaggcgac caatcacaac ctccatatca cagagaagct 840 ggaagttctg gccaaagcct acagtgttca gggagacaag tggagggccc tgggctatgc 900 caaggccatc aatgccctca agagcttcca taagcctgtc acctcgtacc aggaggcctg 960 cagtatccct gggattggga agcggatggc tgagaaaatc atagagatcc tggagagcgg 1020 gcatttgcgg aagctggacc atatcagtga gagcgtgcct gtcttggagc tcttctccaa 1080 catctgggga gctgggacca agactgccca gatgtggtac caacagggct tccgaagtct 1140 ggaagacatc cgcagccagg cctccctgac aacccagcag gccatcggcc tgaagcatta 1200 cagtgacttc ctggaacgta tgcccaggga ggaggctaca gagattgagc agacagtcca 1260 gaaagcagcc caggccttta actctgggct gctgtgtgtg gcatgtggtt cataccgacg 1320 gggaaaggcg acctgtggtg atgtcgacgt gctcatcact cacccagatg gccggtccca 1380 ccggggtatc ttcagccgcc tccttgacag tcttcggcag gaagggttcc tcacagatga 1440 cttggtgagc caagaggaga atggtcagca acagaagtac ttgggggtgt gccggctccc 1500 agggccaggg cggcggcacc ggcgcctgga catcatcgtg gtgccctata gcgagtttgc 1560 ctgtgccctg ctctacttca ccggctctgc acacttcaac cgctccatgc gagccctggc 1620 caaaaccaag ggcatgagtc tgtcagaaca tgccctcagc actgctgtgg tccggaacac 1680 ccatggctgc aaggtggggc ctggccgagt gctgcccact cccactgaga aggatgtctt 1740 caggctctta ggcctcccct accgagaacc tgctgagcgg gactggtgac ccatggctgg 1800 gggtgctgag gagagccgag ttggactggc tacccctcct ggccacccag tactccctcc 1860 agcctcagct ggctgaacct cgccgctcca accaccagct tcctcagcga gcagggccca 1920 gggctctggg cctgaagcaa gagccagccc ggctcccagt gtctgcccgg ctcccagtgt 1980 ctgcccagcc ctctcccaga caggagcagg ctgccacccc ttctacctca ccactgcccc 2040 tcgaagaatt ttgcaaatgg ccccttgccc cattttaagc aggagcaggt ggctggtttg 2100 aagccccagg tatccccctt ccctgctatg ggaaaggcca agctgctggg tggggacaga 2160 agctgcaggg gagagggaag cagccgtgct gtcaacatca tccggcaccc tctggggtag 2220 gagaacagcc attccacatg tgttccctct atccgtcctg cttcctgggc agctggtggt 2280 gctgggaatg gggtgcccca gccttggtga ggacagtgtt gggaggccca ggggcccagt 2340 aaagtgcatt tgacattgaa aaaaaaaa 2368 <210> 869 <211> 2281 <212> DNA <213> Homo sapiens <400> 869 aaaattctgg ccatttgccc tccttccccc cttcgtccgc tctcattggc tctgctgcag 60 ccctgaccaa cgctccaata ggccgggatc cagccatact tcaatggatc ccaggggtat 120 cttgaaggca tttcccaagc ggcagaaaat tcatgctgat gcatcatcaa aagtacttgc 180 aaagattcct aggagggaag agggagaaga agcagaagag tggctgagct cccttcgggc 240 ccatgttgtg cgcactggca ttggacgagc ccgggcagaa ctctttgaga agcagattgt 300 tcagcatggc ggccagctat gccctgccca gggcccaggt gtcactcaca ttgtggtgga 360 tgaaggcatg gactatgagc gagccctccg ccttctcaga ctaccccagc tgcccccggg 420 tgctcagctg gtgaagtcag cctggctgag cttgtgcctt caggagagga ggctggtgga 480 tgtagctgga ttcagcatct tcatccccag taggtacttg gaccatccac agcccagcaa 540 ggcagagcag gatgcttcta ttcctcctgg cacccatgag gccctgcttc agacagccct 600 ttctcctcct cctcctccca ccaggcctgt gtctcctccc caaaaggcaa aagaggcacc 660 aaacacccaa gcccagccca tctccgatga tgaagccagt gatggggaag aaacccaggt 720 tagtgcagct gatctggaag ccctcatcag tggccactac cccacctccc ttgagggaga 780 ttgtgagcct agcccagccc ctgctgtcct ggataagtgg gtctgtgcac agccctcaag 840 ccagaaggcg accaatcaca acctccatat cacagagaag ctggaagttc tggccaaagc 900 ctacagtgtt cagggagaca agtggagggc cctgggctat gccaaggcca tcaatgccct 960 caagagcttc cataagcctg tcacctcgta ccaggaggcc tgcagtatcc ctgggattgg 1020 gaagcggatg gctgagaaaa tcatagagat cctggagagc gggcatttgc ggaagctgga 1080 ccatatcagt gagagcgtgc ctgtcttgga gctcttctcc aacatctggg gagctgggac 1140 caagactgcc cagatgtggt accaacaggg cttccgaagt ctggaagaca tccgcagcca 1200 ggcctccctg acaacccagc aggccatcgg cctgaagcat tacagtgact tcctggaacg 1260 tatgcccagg gaggaggcta cagagattga gcagacagtc cagaaagcag cccaggcctt 1320 taactctggg ctgctgtgtg tggcatgtgg ttcataccga cggggaaagg cgacctgtgg 1380 tgatgtcgac gtgctcatca ctcacccaga tggccggtcc caccggggta tcttcagccg 1440 cctccttgac agtcttcggc aggaagggtt cctcacagat gacttggtga gccaagagga 1500 gaatggtcag caacagaagt acttgggggt gtgccggctc ccagggccag ggcgccggca 1560 ccggcgcctg gacatcatcg tggtgcccta tagcgagttt gcctgtgccc tgcaaggtgg 1620 ggcctggccg agtgctgccc actcccactg agaaggatgt cttcaggctc ttaggcctcc 1680 cctaccgaga acctgctgag cgggactggt gacccatggc tgggggtgct gaggagagcc 1740 gagttggact ggctacccct cctggccacc cagtactccc tccagcctca gctggctgaa 1800 cctcgccgct ccaaccacca gcttcctcag cgagcagggc ccagggctct gggcctgaag 1860 caagagccag cccggctccc agtgtctgcc cggctcccag tgtctgccca gccctctccc 1920 agacaggagc aggctgccac cccttctacc tcaccactgc ccctcgaaga attttgcaaa 1980 tggccccttg ccccatttta agcaggagca ggtggctggt ttgaagcccc aggtatcccc 2040 cttccctgct atgggaaagg ccaagctgct gggtggggac agaagctgca ggggagaggg 2100 aagcagccgt gctgtcaaca tcatccggca ccctctgggg taggagaaca gccattccac 2160 atgtgttccc tctatccgtc ctgcttcctg ggcagctggt ggtgctggga atggggtgcc 2220 ccagccttgg tgaggacagt gttgggaggc ccaggggccc agtaaagtgc atttgacatt 2280 g 2281 <210> 870 <211> 2306 <212> DNA <213> Homo sapiens <400> 870 atttgccctc cttcccccct tcgtccgctc tcattggctc tgctgccttc atgtgcttca 60 gccctacgtt gtttatgtcc agaatcagat attggagctg actctgcctg tccagggcct 120 gcagagtggc tgagctccct tcgggcccat gttgtgcgca ctggcattgg acgagcccgg 180 gcagaactct ttgagaagca gattgttcag catggcggcc agctatgccc tgcccagggc 240 ccaggtgtca ctcacattgt ggtggatgaa ggcatggact atgagcgagc cctccgcctt 300 ctcagactac cccagctgcc cccgggtgct cagctggtga agtcagcctg gctgagcttg 360 tgccttcagg agaggaggct ggtggatgta gctggattca gcatcttcat ccccagtagg 420 tacttggacc atccacagcc cagcaaggca gagcaggatg cttctattcc tcctggcacc 480 catgaggccc tgcttcagac agccctttct cctcctcctc ctcccaccag gcctgtgtct 540 cctccccaaa aggcaaaaga ggcaccaaac acccaagccc agcccatctc tgatgatgaa 600 gccagtgatg gggaagaaac ccaggttagt gcagctgatc tggaagccct catcagtggc 660 cactacccca cctcccttga gggagattgt gagcctagcc cagcccctgc tgtcctggat 720 aagtgggtct gtgcacagcc ctcaagccag aaggcgacca atcacaacct ccatatcaca 780 gagaagctgg aagttctggc caaagcctac agtgttcagg gagacaagtg gagggccctg 840 ggctatgcca aggccatcaa tgccctcaag agcttccata agcctgtcac ctcgtaccag 900 gaggcctgca gtatccctgg gattgggaag cggatggctg agaaaatcat agagatcctg 960 gagagcgggc atttgcggaa gctggaccat atcagtgaga gcgtgcctgt cttggagctc 1020 ttctccaaca tctggggagc tgggaccaag actgcccaga tgtggtacca acagggcttc 1080 cgaagtctgg aagacatccg cagccaggcc tccctgacaa cccagcaggc catcggcctg 1140 aagcattaca gtgacttcct ggaacgtatg cccagggagg aggctacaga gattgagcag 1200 acagtccaga aagcagccca ggcctttaac tctgggctgc tgtgtgtggc atgtggttca 1260 taccgacggg gaaaggcgac ctgtggtgat gtcgacgtgc tcatcactca cccagatggc 1320 cggtcccacc ggggtatctt cagccgcctc cttgacagtc ttcggcagga agggttcctc 1380 acagatgact tggtgagcca agaggagaat ggtcagcaac agaagtactt gggggtgtgc 1440 cggctcccag ggccagggcg gcggcaccgg cgcctggaca tcatcgtggt gccctatagc 1500 gagtttgcct gtgccctgct ctacttcacc ggctctgcac acttcaaccg ctccatgcga 1560 gccctggcca aaaccaaggg catgagtctg tcagaacatg ccctcagcac tgctgtggtc 1620 cggaacaccc atggctgcaa ggtggggcct ggccgagtgc tgcccactcc cactgagaag 1680 gatgtcttca ggctcttagg cctcccctac cgagaacctg ctgagcggga ctggtgaccc 1740 atggctgggg gtgctgagga gagccgagtt ggactggcta cccctcctgg ccacccagta 1800 ctccctccag cctcagctgg ctgaacctcg ccgctccaac caccagcttc ctcagcgagc 1860 agggcccagg gctctgggcc tgaagcaaga gccagcccgg ctcccagtgt ctgcccggct 1920 cccagtgtct gcccagccct ctcccagaca ggagcaggct gccacccttt ctacctcacc 1980 actgcccctc gaagaatttt gcaaatggcc ccttgcccca ttttaagcag gagcaggtgg 2040 ctggtttgaa gccccaggta tcccccttcc ctgctatggg aaaggccaag ctgctgggtg 2100 gggacagaag ctgcagggga gagggaagca gccgtgctgt caacatcatc cggcaccctc 2160 tggggtagga gaacagccat tccacatgtg ttccctctat ccgtcctgct tcctgggcag 2220 ctggtggtgc tgggaatggg gtgccccagc cttggtgagg acagtgttgg gaggcccagg 2280 ggcccagtaa agtgcatttg acattg 2306 <210> 871 <211> 1553 <212> DNA <213> Homo sapiens <400> 871 cctggctctg cccacaatca ccagggcagc ttggtaagga tgaagatgac aaggtccatc 60 ctcagactga tggaatcatg aacgagcatc ttaggatagt ggcagggctg gatgatggca 120 tgtttcccat gctccctgcc tttcccaagt cctgctgagt acagacccaa ctgcccctag 180 gttggtcctg cctctagcct tccctagagt ctggggcgat ggaagccttg tgtgtgtgct 240 cactcatgcc tcttcattgg tcctggatcc ttacagcttc ccatctggct gcttttttcc 300 agggcttccg aagtctggaa gacatccgca gccaggcctc cctgacaacc cagcaggcca 360 tcggcctgaa gcattacagt gacttcctgg aacgtatgcc cagggaggag gctacagaga 420 ttgagcagac agtccagaaa gcagcccagg cctttaactc tgggctgctg tgtgtggcat 480 gtggttcata ccgacgggga aaggcgacct gtggtgatgt cgacgtgctc atcactcacc 540 cagatggccg gtcccaccgg ggtatcttca gccgcctcct tgacagtctt cggcaggaag 600 ggttcctcac agatgacttg gtgagccaag aggagaatgg tcagcaacag aagtacttgg 660 gggtgtgccg gctcccaggg ccagggcggc ggcaccggcg cctggacatc atcgtggtgc 720 cctatagcga gtttgcctgt gccctgctct acttcaccgg ctctgcacac ttcaaccgct 780 ccatgcgagc cctggccaaa accaagggca tgagtctgtc agaacatgcc ctcagcactg 840 ctgtggtccg gaacacccat ggctgcaagg tggggcctgg ccgagtgctg cccactccca 900 ctgagaagga tgtcttcagg ctcttaggcc tcccctaccg agaacctgct gagcgggact 960 ggtgacccat ggctgggggt gctgaggaga gccgagttgg actggctacc cctcctggcc 1020 acccagtact ccctccagcc tcagctggct gaacctcgcc gctccaacca ccagcttcct 1080 cagcgagcag ggcccagggc tctgggcctg aagcaagagc cagcccggct cccagtgtct 1140 gcccggctcc cagtgtctgc ccagccctct cccagacagg agcaggctgc caccccttct 1200 acctcaccac tgcccctcga agaattttgc aaatggcccc ttgccccatt ttaagcagga 1260 gcaggtggct ggtttgaagc cccaggtatc ccccttccct gctatgggaa aggccaagct 1320 gctgggtggg gacagaagct gcaggggaga gggaagcagc cgtgctgtca acatcatccg 1380 gcaccctctg gggtaggaga acagccattc cacatgtgtt tccctctatc cgtcctgctt 1440 cctgggcagc tggtggtgct gggaatgggg tgccccagcc ttggtgagga cagtgttggg 1500 aggcccaggg gcccagtaaa gtgcatttga cattgaaaaa aaaaaaaaaa aaa 1553 <210> 872 <211> 1728 <212> DNA <213> Homo sapiens <400> 872 atggatccca ggggtatctt gaaggcattt cccaagcggc agaaaattca tgctgatgca 60 tcatcaaaag tacttgcaaa gattcctagg agggaagagg gagaagaagc agaagagtgg 120 ctgagctccc ttcgggccca tgttgtgcgc actggcattg gacgagcccg ggcagaactc 180 tttgagaagc agattgttca gcatggcggc cagctatgcc ctgcccaggg cccaggtgtc 240 actcacattg tggtggatga aggcatggac tatgagcgag ccctccgcct tctcagacta 300 ccccagctgc ccccgggtgc tcagctggtg aagtcagcct ggctgagctt gtgccttcag 360 gagaggaggc tggtggatgt agctggattc agcatcttca tccccagtag gtgcttggac 420 catccacagc ccagcaaggc agagcaggat gcttctattc ctcctggcac ccatgaggcc 480 ctgcttcaga cagccctttc tcctcctcct cctcccacca ggcctgtgtc tcctccccaa 540 aaggcaaaag aggcaccaaa cacccaagcc cagcccatct ctgatgatga agccagtgat 600 ggggaagaaa cccaggttag tgcagctgat ctggaggccc tcatcagtgg ccactacccc 660 acctcccttg agggagattg tgagcctagc ccagcccctg ctgtcctgga taagtgggtc 720 tgtgcacagc cctcaagcca gaaggcgacc aatcacaacc tccatatcac agagaagctg 780 gaagttctgg ccaaagccta cagtgttcag ggagacaagt ggagggccct gggctatgcc 840 aaggccatca atgccctcaa gagcttccat aagcctgtca cctcgtacca ggaggcctgc 900 agtatccctg ggattgggaa gcggatggct gagaaaatca tagagatcct ggagagcggg 960 catttgcgga agctggacca tatcagtgag agcgtgcctg tcttggagct cttctccaac 1020 atctggggag ctgggaccaa gactgcccag atgtggtacc aacagggctt ccgaagtctg 1080 gaagacatcc gcagccaggc ctccctgaca acccagcagg ccatcggcct gaagcattac 1140 agtgacttcc tggaacgtat gcccagggag gaggctacag agattgagca gacagtccag 1200 aaagcagccc aggcctttaa ctctgggctg ctgtgtgtgg catgtggttc ataccgacgg 1260 ggaaaggcga cctgtggtga tgtcgacgtg ctcatcactc acccagatgg ccggtcccac 1320 cggggtatct tcagccgcct ccttgacagt cttcggcagg aagggttcct cacagatgac 1380 ttggtgagcc aagaggagaa tggtcagcaa cagaagtact tgggggtgtg ccggctccca 1440 gggccagggc ggcggcaccg gcgcctggac atcatcgtgg tgccctatag cgagtttgcc 1500 tgtgccctgc tctacttcac cggctctgca cacttcaacc gctccatgcg agccctggcc 1560 aaaaccaagg gcatgagtct gtcagaacat gccctcagca ctgctgtggt ccggaacacc 1620 catggctgca aggtggggcc tggccgagtg ctgcccactc ccactgagaa ggatgtcttc 1680 aggctcttag gcctccccta ccgagaacct gctgagcggg actggtga 1728 <210> 873 <211> 2380 <212> DNA <213> Homo sapiens <400> 873 ggttggagag actcttgggg ccggggtcgg gcactccagc tttcttctag ccccgagctg 60 ggattccctg gcctgcgcca gctgcgtaca cggcgagtac accgcacctg cccgggactt 120 cacccgcagc tgcgagactc ctccattccc ggagggctcc ccacacctgc tgcggccgtg 180 ccccatctcc ccgcagctgc ggcgctgagc acccccatgt cgagaggctg agaccaggac 240 aggtgcaggg cgttcccact cacccccgaa agtcctcctc cttcctctgc gagtctgtgt 300 tggaggtaga gaaatagtat gtggggttta tgtgcaggtc ctccccaggc tccgctccat 360 cccctaaagc tccatttcct agcccagcat cccatttggt aaagcccttc gaagtgggcc 420 gcagcagggc tgtgctgaat ctttagcgca acccctctga ggaatggtgt cgtttcctac 480 tcctcaaaag tacccccgat ggcaccagcc ttcccctcat ttcccgtaat actccaactt 540 cgaaaggctg gggagtgtga agctaggcta aaccactgaa gtttaaccgg gtttgaagag 600 accccctccc ccgacccgct tccccaaact gggctgctac ccccaaagcc tggtcaggaa 660 agaccctacc tccataggca aaggggttgg agggcctcaa ttctggattt ccacgtgcag 720 cagccctgac caacgctcca ataggccggg atccagccat acttcaatgg atcccagggg 780 tatcttgaag gcatttccca agcggcagaa aattcatgct gatgcatcat caaaagtact 840 tgcaaagatt cctaggaggg aagagggaga agaagcagaa ggaggcctgc agtatccctg 900 ggattgggaa gcggatggct gagaaaatca tagagatcct ggagagcggg catttgcgga 960 agctggacca tatcagtgag agcgtgcctg tcttggagct cttctccaac atctggggag 1020 ctgggaccaa gactgcccag atgtggtacc aacagggctt ccgaagtctg gaagacatcc 1080 gcagccaggc ctccctgaca acccagcagg ccatcggcct gaagcattac agtgacttcc 1140 tggaacgtat gcccagggag gaggctacag agattgagca gacagtccag aaagcagccc 1200 aggcctttaa ctctgggctg ctgtgtgtgg catgtggttc ataccgacgg ggaaaggcga 1260 cctgtggtga tgtcgacgtg ctcatcactc acccagatgg ccggtcccac cggggtatct 1320 tcagccgcct ccttgacagt cttcggcagg aagggttcct cacagatgac ttggtgagcc 1380 aagaggagaa tggtcagcaa cagaagtact tgggggtgtg ccggctccca gggccagggc 1440 ggcggcaccg gcgcctggac atcatcgtgg tgccctatag cgagtttgcc tgtgccctgc 1500 tctacttcac cggctctgca cacttcaacc gctccatgcg agccctggcc aaaaccaagg 1560 gcatgagtct gtcagaacat gccctcagca ctgctgtggt ccggaacacc catggctgca 1620 aggtggggcc tggccgagtg ctgcccactc ccactgagaa ggatgtcttc aggctcttag 1680 gcctccccta ccgagaacct gctgagcggg actggtgacc catggctggg ggtgctgagg 1740 agagccgagt tggactggct acccctcctg gccacccagt actccctcca gcctcagctg 1800 gctgaacctc gccgctccaa ccaccagctt cctcagcgag cagggcccag ggctctgggc 1860 ctgaagcaag agccagcccg gctcccagtg tctgcccggc tcccagtgtc tgcccagccc 1920 tctcccagac aggagcaggc tgccacccct tctacctcac cactgcccct cgaagaattt 1980 tgcaaatggc cccttgcccc attttaagca ggagcaggtg gctggtttga agccccaggt 2040 atcccccttc cctgctatgg gaaaggccaa gctgctgggt ggggacagaa gctgcagggg 2100 agagggaagc agccgtgctg tcaacatcat ccggcaccct ctggggtagg agaacagcca 2160 ttccacatgt gttccctcta tccgtcctgc ttcctgggca gctggtggtg ctgggaatgg 2220 ggtgccccag ccttggtgag gacagtgttg ggaggcccag gggcccagta aagtgcattt 2280 gacattgaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2340 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaacctcggg 2380 <210> 874 <211> 1871 <212> DNA <213> Homo sapiens <400> 874 gaggtgtccg gggccccaga attttcagtg tcctggggtg gaggcaggag gccatctgca 60 tatgaaagaa cctcagtgtc tcaggggtgg aggctaatgg gtttattttt cctcagaggg 120 acaatccttc agctggcagt tgctgtctca gctccctccc caccaagaaa ggatgtgggt 180 gttggctcag aactgccccc tctttgcttt ctttcctctc ctttcccaca ggtgcagctg 240 tatttctgtg ctccactttc tcctgggcct gggcctggcg catgctgcca gccacctgct 300 cagtcctcaa accccagctc acatattcca aacctttagc tccaaatcag tagatatctg 360 gggctgccta gacctggctg agggctttca gcacctggcc ccttgtccta agtggagttt 420 cacagacctg ggcacgtggg ctggggcagg ggcagagaga gtctgtgtct ccctactctt 480 aaagagctcc acagggcaag ctcagtgccc actctcagaa gcagagccgg caccttctcc 540 cgtctctcct caggcttgcc tcctgcacag tgagcttttt cttctctcct gtcctagcga 600 agggaaagaa cagcagctcc tcagggtgga ttcccctggg cttgcagcag gcatctggaa 660 tgggcataag ctgagggtgt gggcccgagt ctgggaaggc ccttgtactg ctgtgggaga 720 ggagctcccc acgcacagcc cctcacctgt caccgctctc tttcccaggt ccagaaagca 780 gcccaggcct ttaactctgg gctgctgtgt gtggcatgtg gttcataccg acggggaaag 840 gcgacctgtg gtgatgtcga cgtgctcatc actcacccag atggccggtc ccaccggggt 900 atcttcagcc gcctccttga cagtcttcgg caggaagggt tcctcacaga tgacttggtg 960 agccaagagg agaatggtca gcaacagaag tacttggggg tgtgccggct cccagggcca 1020 gggcggcggc accggcgcct ggacatcatc gtggtgccct atagcgagtt tgcctgtgcc 1080 ctgctctact tcaccggctc tgcacacttc aaccgctcca tgcgagccct ggccaaaacc 1140 aagggcatga gtctgtcaga acatgccctc agcactgctg tggtccggaa cacccatggc 1200 tgcaaggtgg ggcctggccg agtgctgccc actcccactg agaaggatgt cttcaggctc 1260 ttaggcctcc cctaccgaga acctgctgag cgggactggt gacccatggc tgggggtgct 1320 gaggagagcc gagttggact ggctacccct cctggccacc cagtactccc tccagcctca 1380 gctggctgaa cctcgccgct ccaaccacca gcttcctcag cgagcagggc ccagggctct 1440 gggcctgaag caagagccag cccggctccc agtgtctgcc cggctcccag tgtctgccca 1500 gccctctccc agacaggagc aggctgccac cccttctacc tcaccactgc ccctcgaaga 1560 attttgcaaa tggccccttg ccccatttta agcaggagca ggtggctggt ttgaagcccc 1620 aggtatcccc cttccctgct atgggaaagg ccaagctgct gggtggggac agaagctgca 1680 ggggagaggg aagcagccgt gctgtcaaca tcatccggca ccctctgggg taggagaaca 1740 gccattccac atgtgttccc tctatccgtc ctgcttcctg ggcagctggt ggtgctggga 1800 atggggtgcc ccagccttgg tgaggacagt gttgggaggc ccaggggccc agtaaagtgc 1860 atttgacatt g 1871 <210> 875 <211> 2589 <212> DNA <213> Homo sapiens <400> 875 gtttccctct gcgttcgctc cgcgctgctg gaggctgtcg tcccaatgct ccccaaacgg 60 cggcgagcgc gggtcgggtc ccctagcggc gatgccgctt cctccacgcc gccctcgacg 120 cgcttcccgg gagtcgccat ctacctggtc gagcctcgca tgggtcgcag ccgccgggcc 180 ttcctcacag gcctggcgcg ctccaaaggc ttccgcgtcc ttgacgcctg cagctccgaa 240 gcgacacatg ttgtgatgga agagacctca gcagaggagg ccgtcagctg gcaggagcgc 300 aggatggcag ctgctccccc gggttgcacc cccccagctc tgctggacat aagctggtta 360 acagagagcc tgggagctgg gcagcctgta cctgtggagt gccggcaccg cctggaggtg 420 gctgggccaa ggaaggggcc tctgagccca gcatggatgc ctgcctatgc ctgccagcgc 480 cctacgcccc tcacacacca caacactggc ctctccgagg ctctggagat actggccgag 540 gcagcaggct ttgaaggcag tgagggccgc ctcctcacct tctgcagagc agcctcggtg 600 ctcaaggccc ttcccagccc tgtcacaacc ctgagccagc tgcaggggct tccccacttt 660 ggagaacact cctctagggt tgtccaggag ctgctggagc atggagtgtg tgaggaggtg 720 gagagagttc ggcgctcaga gaggtaccag accatgaagc tcttcaccca gatcttcggg 780 gtcggtgtga agactgctga ccggtggtac cgggaaggac tgcgaacctt agatgacctc 840 cgagagcagc cccagaaact aacccaacag cagaaagcgg ggctccagca ccaccaggac 900 ctgagcaccc cagtcctgcg gtccgatgta gatgccctgc agcaggtggt ggaggaagct 960 gtggggcagg ccctgcctgg ggccaccgtc acgctgaccg gcggcttccg cagggggaag 1020 ttgcagggcc atgacgtgga cttcctcatc acccacccca aggagggtca ggaggcgggg 1080 ctgctgccta gagtgatgtg ccgcctgcag gaccagggcc tcatcctgta ccaccagcac 1140 cagcacagct gctgtgagtc ccctacccgc ctggcccaac agagccacat ggacgctttt 1200 gagagaagtt tctgcatttt ccgcctacca caacctccag gggctgctgt ggggggatcc 1260 acgaggccct gcccatcctg gaaggccgtg agagtggact tggtagttgc acccgtcagc 1320 cagttccctt tcgccctgct cggttggact ggctccaagc ttttccagcg ggagctgcgc 1380 cgcttcagcc ggaaggagaa gggcctgtgg ctgaacagcc atgggctgtt tgacccggag 1440 cagaagacat ttttccaagc ggcttcagag gaagacatct tcagacacct gggccttgag 1500 taccttcctc cagagcagag aaacgcctga acctgcctgt gtcccccact tccactcagg 1560 aaattgggct gcccccaaac tggccactga atgtctccaa gcaaatatgc tgccccctga 1620 ccccaccttc aaccctcccc gccaaggcct ggctcttccg gaggtcaatt gtgcctgcag 1680 gatcagttga gcccctgctg gtgtgctgca gggtgtgatg aggtgggagc cctcagtgcc 1740 agcctcatca ctgtgtgacc ctgggtctgc tcttagcctc cccatggctc acgttcctgc 1800 cctggatggg atgtgagtgg ggcccacatc gtggagctgt ggtggggcct gcagtcatga 1860 atggcaagtg gtccctgatg tgcagtgtct cattagttgc actgcagtta actgtggctc 1920 ctgcagggca ccctgcccag aatgcccaga agagaaccat gcatacctgc actgcatttg 1980 agagccatga gctggaggct gtggttcgtg ccagcaagga gcctactgtc tggtgtgctg 2040 taggcatctg gagagggaga gggcctgggt aggagctggg aggaagataa ttttcaacta 2100 tggggcttca gtactgcagc gccccgaagc caggctctgt gcttctgcct ttaaggcctg 2160 ttctcagcac aatgtctcaa aaataggtca tatcctgcca ctcccgtcgc agagcccttt 2220 aatggttcca aaccctaagt ccacacatag cccctggctc tggcatctct ccagccccac 2280 tggccccgag ctgcttgact caccggcttc ctatttgatg cacccaggcc cccttgtggc 2340 caactccctc cccttctcac tgaggcagaa gcactgaggt gggctggaca tgggtgccct 2400 ccacgtccct catatcccca ggcacactct ggcctcaggt tttgccctgg ccatgtcatc 2460 tacctggagt gggccctccc cttcttcagg ccttgaatca aaagccactt tgttaggcga 2520 ggatttccca gaccactcat cacattaaaa aatattttga aaacatgcag taaaaaaaaa 2580 aaaaaaaaa 2589 <210> 876 <211> 2411 <212> DNA <213> Homo sapiens <400> 876 gagtttccct ctgcgttcgc tccgcgctgc tggaggctgt cgtcccaatg ctccccaaac 60 ggcggcgagc gcgggtcggg tcccctagcg gcgatgccgc ttcctccacg ccgccctcga 120 cgcgcttccc gggagtcgcc atctacctgg tcgagcctcg catgggtcgc agccgccggg 180 ccttcctcac aggcctggcg cgctccaaag gcttccgcgt ccttgacgcc tgcagctccg 240 aagcgacaca tgttgtgatg gaagagacct cagcagagga ggccgtcagc tggcaggagc 300 gcaggatggc agctgctccc ccgggttgca cccccccagc tctgctggac ataagctggt 360 taacagagag cctgggagct gggcagcctg tacctgtgga gtgccggcac cgcctggagg 420 tggctgggcc aaggaagggg cctctgagcc cagcatggat gcctgcctat gcctgccagc 480 gccctacgcc cctcacacac cacaacactg gcctctccga ggctctggag atactggccg 540 aggcagcagg ctttgaaggc agtgagggcc gcctcctcac cttctgcaga gcagcctcgg 600 tgctcaaggc ccttcccagc cctgtcacaa ccctgagcca gctgcagggg cttccccact 660 ttggagaaca ctcctctagg gttgtccagg agctgctgga gcatggagtg tgtgaggagg 720 tggagagagt tcggcgctca gagagggctc cagcaccacc aggacctgag caccccagtc 780 ctgcggtccg atgtagatgc cctgcagcag gtggtggagg aagctgtggg gcaggccctg 840 cctggggcca ccgtcacgct gaccggcggc ttccgcaggg cctcatcctg taccaccagc 900 accagcacag ctgctgtgag tcccctaccc gcctggccca acagagccac atggacgctt 960 ttgagagaag tttctgcatt ttccgcctac cacaacctcc aggggctgct gtggggggat 1020 ccacgaggcc ctgcccatcc tggaaggccg tgagagtgga cttggtagtt gcacccgtca 1080 gccagttccc tttcgccctg ctcggttgga ctggctccaa gcttttccag cgggagctgc 1140 gccgcttcag ccggaaggag aagggcctgt ggctgaacag ccatgggctg tttgacccgg 1200 agcagggaag cagcagtggc aagactccta ggtcacggaa gtcctgcttc tgttgcagaa 1260 gacatttttc caagcggctt cagaggaaga catcttcaga cacctgggcc ttgagtacct 1320 tcctccagag cagagaaacg cctgagcctg cctgtgtccc ccacttccac tcaggaaatt 1380 gggctgcccc caacctggcc actgaatgtc tccaggcaga tatgctgccc cctgaccccc 1440 accttcaccc ctccccgcca aggcctggct cttccggagg tcaattgtgc ctgcaggatc 1500 agttgagccc ctgctggtgt gctgcagggt gtgatgaggt gggagccctc agtgccagcc 1560 tcatcactgt gtgaccctgg gtctgctctt agcctcccca tggctcacgt tcctgccctg 1620 gatgggatgt gagtggggcc cacatcgtgg agctgtggtg gggcctgcag tcatgaatgg 1680 caagtggtcc ctgatgtgca gtgtctcatt agttgcactg cagttaactg tggctcctgc 1740 agggcaccct gcccagaatg cccagaagag aaccatgcat acctgcactg catttgagag 1800 ccatgagctg gaggctgtgg ttcgtgccag caaggagcct actgtctggt gtgctgtagg 1860 catctggaga gggagagggc ctgggtagga gctgggagga agataatttt caactatggg 1920 gcttcagtac tgcagcgccc cgagccaggc tctgtgcttc tgcctttaag gcctgttctc 1980 agcacaatgt ctcaaaaata ggtcatatcc tgccactccc gtcgcagagc cctttaatgg 2040 ttccaaaccc taagtccaca catagcccct ggctctggca tctctccagc cccactggcc 2100 ccgagctgct tgactcaccg gcttcctatt tgatgcaccc aggccccctt gtggccaact 2160 ccctcccctt ctcactgagg cagaagcact gaggtgggct ggacatgggt gccctccacg 2220 tccctcatat ccccaggcac actctggcct caggttttgc cctggccatg tcatctacct 2280 ggagtgggcc ctccccttct tcaggccttg aatcaaaagc cactttgtta ggcgaggatt 2340 tcccagacca ctcatcacat taaaaaatat tttgaaaaca aaaaaaaaaa aaaaaaaaaa 2400 aaaaaaaaaa a 2411 <210> 877 <211> 2490 <212> DNA <213> Homo sapiens <400> 877 ccgcgctgct ggaggctgtc gtcccaatgc tccccaaacg gcggcgagcg cgggtcgggt 60 cccctagcgg cgatgccgct tcctccacgc cgccctcgac gcgcttcccg ggagtcgcca 120 tctacctggt cgagcctcgc atgggtcgca gccgccgggc cttcctcaca ggcctggcgc 180 gctccaaagg cttccgcgtc cttgacgcct gcagctccga agcgacacat gttgtgatgg 240 aagagacctc agcagaggag gccgtcagct ggcaggagcg caggatggca gctgctcccc 300 cgggttgcac ccccccagct ctgctggaca taagctggtt aacagagagc ctgggagctg 360 ggcagcctgt acctgtggag tgccggcacc gcctggaggt ggctgggcca aggaaggggc 420 ctctgagccc agcatggatg cctgcctatg cctgccagcg ccctacgccc ctcacacacc 480 acaacactgg cctctccgag gctctggaga tactggccga ggcagcaggc tttgaaggca 540 gtgagggccg cctcctcacc ttctgcagag cagcctcggt gctcaaggcc cttcccagcc 600 ctgtcacaac cctgagccag ctgcaggggc ttccccactt tggagaacac tcctctaggg 660 ttgtccagga gctgctggag catggagtgt gtgaggaggt ggagagagtt cggcgctcag 720 agaggtacca gaccatgaag ctcttcaccc agatcttcgg ggtcggtgtg aagactgctg 780 accggtggta ccgggaagga ctgcgaacct tagatgacct ccgagagcag ccccagaaac 840 taacccaaca gcagaaagcg gcaccaccag gacctgagca ccccagtcct gcggtccgat 900 gtagatgccc tgcagcaggt ggtggaggaa gctgtggggc aggccctgcc tggggccacc 960 gtcacgctga ccggcggctt ccgcagggcc tcatcctgta ccaccagcac cagcacagct 1020 gctgtgagtc ccctacccgc ctggcccaac agagccacat ggacgctttt gagagaagtt 1080 tctgcatttt ccgcctacca caacctccag gggctgctgt ggggggatcc acgaggccct 1140 gcccatcctg gaaggccgtg agagtggact tggtagttgc acccgtcagc cagttccctt 1200 tcgccctgct cggttggact ggctccaagc ttttccagcg ggagctgcgc cgcttcagcc 1260 ggaaggagaa gggcctgtgg ctgaacagcc atgggctgtt tgacccggag cagaagacat 1320 ttttccaagc ggcttcagag gaagacatct tcagacacct gggccttgag taccttcctc 1380 cagagcagag aaacgcctga gcctgcctgt gtcccccact tccactcagg aaattgggct 1440 gcccccaacc tggccactga atgtctccag gcagatatgc tgccccctga cccccacctt 1500 cacccctccc cgccaaggcc tggctcttcc ggaggtcaat tgtgcctgca ggatcagttg 1560 agcccctgct ggtgtgctgc agggtgtgat gaggtgggag ccctcagtgc cagcctcatc 1620 actgtgtgac cctgggtctg ctcttagcct ccccatggct cacgttcctg ccctggatgg 1680 gatgtgagtg gggcccacat cgtggagctg tggtggggcc tgcagtcatg aatggcaagt 1740 ggtccctgat gtgcagtgtc tcattagttg cactgcagtt aactgtggct cctgcagggc 1800 accctgccca gaatgcccag aagagaacca tgcatacctg cactgcattt gagagccatg 1860 agctggaggc tgtggttcgt gccagcaagg agcctactgt ctggtgtgct gtaggcatct 1920 ggagagggag agggcctggg taggagctgg gaggaagata attttcaact atggggcttc 1980 agtactgcag cgccccgagc caggctctgt gcttctgcct ttaaggcctg ttctcagcac 2040 aatgtctcaa aaataggtca tatcctgcca ctcccgtcgc agagcccttt aatggttcca 2100 aaccctaagt ccacacatag cccctggctc tggcatctct ccagccccac tggccccgag 2160 ctgcttgact caccggcttc ctatttgatg cacccaggcc cccttgtggc caactccctc 2220 cccttctcac tgaggcagaa gcactgaggt gggctggaca tgggtgccct ccacgtccct 2280 catatcccca ggcacactct ggcctcaggt tttgccctgg ccatgtcatc tacctggagt 2340 gggccctccc cttcttcagg ccttgaatca aaagccactt tgttaggcga ggatttccca 2400 gaccactcat cacattaaaa aatattttga aaacatgcag taaaaaaaaa aaaaaaaaaa 2460 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2490 <210> 878 <211> 3233 <212> DNA <213> Homo sapiens <400> 878 actggggctt ccttccgtct cgctcggagt ttccctctgc gttcgctccg cgctgctgga 60 ggctgtcgtc ccaatgctcc ccaaacggcg gcgagcgcgg gtcgggtccc ctagcggcga 120 tgccgcttcc tccacgccgc cctcgacgcg cttcccggga gtcgccatct acctggtcga 180 gcctcgcatg ggtcgcagcc gccgggcctt cctcacaggc ctggcgcgct ccaaaggctt 240 ccgcgtcctt gacgcctgca gctccgaagc gacacatgtt gtgatggaag agacctcagc 300 agaggaggcc gtcagctggc aggagcgcag gatggcagct gctcccccgg gttgcacccc 360 cccagctctg ctggacataa gctggttaac agagagcctg ggagctgggc agcctgtacc 420 tgtggagtgc cggcaccgcc tggaggtggc tgggccaagg aaggggcctc tgagcccagc 480 atggatgcct gcctatgcct gccagcgccc tacgcccctc acacaccaca acactggcct 540 ctccgaggct ctggagatac tggccgaggc agcaggcttt gaaggcagtg agggccgcct 600 cctcaccttc tgcagagcag cctcggtgct caaggccctt cccagccctg tcacaaccct 660 gagccagctg caggggcttc cccactttgg agaacactcc tctagggttg tccaggagct 720 gctggagcat ggagtgtgtg aggaggtgga gagagttcgg cgctcagaga ggtaccagac 780 catgaaggtg cgcagggcag ggctcggacc taccccagga atgtcctgcc ctgggaatga 840 caacacagtc cacaccatgc acggggaggc aaacaggggc agctgaccca gcccaggggt 900 cagagaaggt cttgccgagg aagtggcagc taagctgata cctgatatgc acaaggcagc 960 caagtggaga caggctggag tgcagtggtg cgatcacagc tcacggcagc cttgacttcc 1020 tgggctcaaa ccatcctccc acctcggtct ctggagtggc tgggactgcg ggcatgtgcc 1080 accacaccag ctcttcaccc agatcttcgg ggtcggtgtg aagactgctg accggtggta 1140 ccgggaagga ctgcgaacct tagatgacct ccgagagcag ccccagaaac taacccaaca 1200 gcagaaagcg gggctccagc accaccagga cctgagcacc ccagtcctgc ggtccgatgt 1260 agatgccctg cagcaggtgg tggaggaagc tgtggggcag gccctgcctg gggccaccgt 1320 cacgctgacc ggcggcttcc gcaggtaaga aggcccgacg tgcccctctg gcttggcttc 1380 agacccctcc ccagtgaagg gacctgagtc ggggaccctg aagcgggccc actcgttgga 1440 agggatgtgg cctggggctg gagtgagcag gccgtgtccc tgagtcagag tcagactgac 1500 gccctcaggg ggaagttgca gggccatgac gtggacttcc tcatcaccca ccccaaggag 1560 ggtcaggagg cggggctgct gcctagagtg atgtgccgcc tgcaggacca ggtgagggcc 1620 tccctgctcc ccaagagcca ccgctggcca atgccactgc ctcctgctct ctccacacca 1680 ccggatggtc tcagccacgc ccgcctctcc ccacagggcc tcatcctgta ccaccagcac 1740 cagcacagct gctgtgagtc ccctacccgc ctggcccaac agagccacat ggacgctttt 1800 gagagaagtt tctgcatttt ccgcctacca caacctccag gggctgctgt ggggggatcc 1860 acgaggccct gcccatactg gaaggccgtg agagtggact tggtagttgc acccgtcagc 1920 cagttccctt tcgccctgct cggttggact ggctccaagc ttttccagcg ggagctgcgc 1980 cgcttcagcc ggaaggagaa gggcctgtgg ctgaacagcc atgggctgtt tgacccggag 2040 cagggaagca gcagtggcaa gactcctagg tcacggaagt cctgcttctg ttgcagaaga 2100 catttttcca agcggcttca gaggaagaca tcttcagaca cctgggcctt gagtaccttc 2160 ctccagagca gagaaacgcc tgagcctgcc tgtgtccccc acttccactc aggaaattgg 2220 gctgccccca acctggccac tgaatgtctc caggcagata tgctgccccc tgacccccac 2280 cttcacccct ccccgccaag gcctggctct tccggaggtc aattgtgcct gcaggatcag 2340 ttgagcccct gctggtgtgc tgcagggtgt gatgaggtgg gagccctcag tgccagcctc 2400 atcactgtgt gaccctgggt ctgctcttag cctccccatg gctcacgttc ctgccctgga 2460 tgggatgtga gtggggccca catcgtggag ctgtggtggg gcgtgcagtc atgaatggca 2520 agtggtccct gatgtgcagt gtctcattag ttgcactgca gttaactgtg gctcctgcag 2580 ggcaccctgc ccagaatgcc cagaagagaa ccatgcatac ctgcactgca tttgagagcc 2640 atgagctgga ggctgtggtt cgtgccagca aggagcctac tgtctggtgt gctgtaggca 2700 tctggagagg gagagggcct gggtaggagc tgggaggaag ataattttca actatggggc 2760 ttcagtactg cagcgccccg agccaggctc tgtgcttctg cctttaaggc ctgttctcag 2820 cacaatgtct caaaaatagg tcatatcctg ccactccagt cgcagagccc tttaatggtt 2880 ccaaacccta agtccacaca tagcccctgg ctctggcatc tctccagccc cactggcccc 2940 gagctgcttg actcaccggc ttcctatttg atgcacccag gcccccttgt ggccaactcc 3000 ctccccttct cactgaggca gaagcactga ggtgggctgg acatgggtgc cctccacgtc 3060 cctcatatcc ccaggcacac tctggcctca ggttttgccc tggccatgtc atctacctgg 3120 agtgggccct ccccttcttc aggccttgaa tcaaaagcca ctttgttagg cgaggatttc 3180 ccagaccact catcacatta aaaaatattt tgaaaacaaa aaaaaaaaaa aaa 3233 <210> 879 <211> 2589 <212> DNA <213> Homo sapiens <400> 879 gtttccctct gcgttcgctc cgcgctgctg gaggctgtcg tcccaatgct ccccaaacgg 60 cggcgagcgc gggtcgggtc ccctagcggc gatgccgctt cctccacgcc gccctcgacg 120 cgcttcccgg gagtcgccat ctacctggtc gagcctcgca tgggtcgcag ccgccgggcc 180 ttcctcacag gcctggcgcg ctccaaaggc ttccgcgtcc ttgacgcctg cagctccgaa 240 gcgacacatg ttgtgatgga agagacctca gcagaggagg ccgtcagctg gcaggagcgc 300 aggatggcag ctgctccccc gggttgcacc cccccagctc tgctggacat aagctggtta 360 acagagagcc tgggagctgg gcagcctgta cctgtggagt gccggcaccg cctggaggtg 420 gctgggccaa ggaaggggcc tctgagccca gcatggatgc ctgcctatgc ctgccagcgc 480 cctacgcccc tcacacacca caacactggc ctctccgagg ctctggagat actggccgag 540 gcagcaggct ttgaaggcag tgagggccgc ctcctcacct tctgcagagc agcctcggtg 600 ctcaaggccc ttcccagccc tgtcacaacc ctgagccagc tgcaggggct tccccacttt 660 ggagaacact cctctagggt tgtccaggag ctgctggagc atggagtgtg tgaggaggtg 720 gagagagttc ggcgctcaga gaggtaccag accatgaagc tcttcaccca gatcttcggg 780 gtcggtgtga agactgctga ccggtggtac cgggaaggac tgcgaacctt agatgacctc 840 cgagagcagc cccagaaact aacccaacag cagaaagcgg ggctccagca ccaccaggac 900 ctgagcaccc cagtcctgcg gtccgatgta gatgccctgc agcaggtggt ggaggaagct 960 gtggggcagg ccctgcctgg ggccaccgtc acgctgaccg gcggcttccg cagggggaag 1020 ttgcagggcc atgacgtgga cttcctcatc acccacccca aggagggtca ggaggcgggg 1080 ctgctgccta gagtgatgtg ccgcctgcag gaccagggcc tcatcctgta ccaccagcac 1140 cagcacagct gctgtgagtc ccctacccgc ctggcccaac agagccacat ggacgctttt 1200 gagagaagtt tctgcatttt ccgcctacca caacctccag gggctgctgt ggggggatcc 1260 acgaggccct gcccatcctg gaaggccgtg agagtggact tggtagttgc acccgtcagc 1320 cagttccctt tcgccctgct cggttggact ggctccaagc ttttccagcg ggagctgcgc 1380 cgcttcagcc ggaaggagaa gggcctgtgg ctgaacagcc atgggctgtt tgacccggag 1440 cagaagacat ttttccaagc ggcttcagag gaagacatct tcagacacct gggccttgag 1500 taccttcctc cagagcagag aaacgcctga acctgcctgt gtcccccact tccactcagg 1560 aaattgggct gcccccaaac tggccactga atgtctccaa gcaaatatgc tgccccctga 1620 ccccaccttc aaccctcccc gccaaggcct ggctcttccg gaggtcaatt gtgcctgcag 1680 gatcagttga gcccctgctg gtgtgctgca gggtgtgatg aggtgggagc cctcagtgcc 1740 agcctcatca ctgtgtgacc ctgggtctgc tcttagcctc cccatggctc acgttcctgc 1800 cctggatggg atgtgagtgg ggcccacatc gtggagctgt ggtggggcct gcagtcatga 1860 atggcaagtg gtccctgatg tgcagtgtct cattagttgc actgcagtta actgtggctc 1920 ctgcagggca ccctgcccag aatgcccaga agagaaccat gcatacctgc actgcatttg 1980 agagccatga gctggaggct gtggttcgtg ccagcaagga gcctactgtc tggtgtgctg 2040 taggcatctg gagagggaga gggcctgggt aggagctggg aggaagataa ttttcaacta 2100 tggggcttca gtactgcagc gccccgaagc caggctctgt gcttctgcct ttaaggcctg 2160 ttctcagcac aatgtctcaa aaataggtca tatcctgcca ctcccgtcgc agagcccttt 2220 aatggttcca aaccctaagt ccacacatag cccctggctc tggcatctct ccagccccac 2280 tggccccgag ctgcttgact caccggcttc ctatttgatg cacccaggcc cccttgtggc 2340 caactccctc cccttctcac tgaggcagaa gcactgaggt gggctggaca tgggtgccct 2400 ccacgtccct catatcccca ggcacactct ggcctcaggt tttgccctgg ccatgtcatc 2460 tacctggagt gggccctccc cttcttcagg ccttgaatca aaagccactt tgttaggcga 2520 ggatttccca gaccactcat cacattaaaa aatattttga aaacatgcag taaaaaaaaa 2580 aaaaaaaaa 2589 <210> 880 <211> 1701 <212> DNA <213> Homo sapiens <400> 880 ccggtggtac cgggaaggac tgcgaacctt agatgacctc cgagagcagc cccagaaact 60 aacccaacag cagaaagcgg ggctccagca ccaccaggac ctgagcaccc cagtcctgcg 120 gtccgatgta gatgccctgc agcaggtggt ggaggaagct gtggggcagg ccctgcctgg 180 ggccaccgtc acgctgaccg gcggcttccg cagggcctca tcctgtacca ccagcaccag 240 cacagctgct gtgagtcccc tacccgcctg gcccaacaga gccacatgga cgcttttgag 300 agaagtttct gcattttccg cctaccacaa cctccagggg ctgctgtggg gggatccacg 360 aggccctgcc catcctggaa ggccgtgaga gtggacttgg tagttgcacc cgtcagccag 420 ttccctttcg ccctgctcgg ttggactggc tccaagcttt tccagcggga gctgcgccgc 480 ttcagccgga aggagaaggg cctgtggctg aacagccatg ggctgtttga cccggagcag 540 ggaagcagca gtggcaagac tcctaggtca cggaagtcct gcttctgttg cagaagacat 600 ttttccaagc ggcttcagag gaagacatct tcagacacct gggccttgag taccttcctc 660 cagagcagag aaacgcctga gcctgcctgt gtcccccact tccactcagg aaattgggct 720 gcccccaacc tggccactga atgtctccag gcagatatgc tgccccctga cccccacctt 780 cacccctccc cgccaaggcc tggctcttcc ggaggtcaat tgtgcctgca ggatcagttg 840 agcccctgct ggtgtgctgc agggtgtgat gaggtgggag ccctcagtgc cagcctcatc 900 actgtgtgac cctgggtctg ctcttagcct ccccatggct cacgttcctg ccctggatgg 960 gatgtgagtg gggcccacat cgtggagctg tggtggggcc tgcagtcatg aatggcaagt 1020 ggtccctgat gtgcagtgtc tcattagttg cactgcagtt aactgtggct cctgcagggc 1080 accctgccca gaatgcccag aagagaacca tgcatacctg cactgcattt gagagccatg 1140 agctggaggc tgtggttcgt gccagcaagg agcctactgt ctggtgtgct gtaggcatct 1200 ggagagggag agggcctggg taggagctgg gaggaagata attttcaact atggggcttc 1260 agtactgcag cgccccgagc caggctctgt gcttctgcct ttaaggcctg ttctcagcac 1320 aatgtctcaa aaataggtca tatcctgcca ctcccgtcgc agagcccttt aatggttcca 1380 aaccctaagt ccacacatag cccctggctc tggcatctct ccagccccac tggccccgag 1440 ctgcttgact caccggcttc ctatttgatg cacccaggcc cccttgtggc caactccctc 1500 cccttctcac tgaggcagaa gcactgaggt gggctggaca tgggtgccct ccacgtccct 1560 catatcccca ggcacactct ggcctcaggt tttgccctgg ccatgtcatc tacctggagt 1620 gggccctccc cttcttcagg ccttgaatca aaagccactt tgttaggcga ggatttccca 1680 gaccactcat cacattaaaa a 1701 <210> 881 <211> 481 <212> DNA <213> Homo sapiens <400> 881 ggagctggga ggaagataat tttcaactat ggggcttcag tactgcagcg ccccgagcca 60 ggctctgtgc ttctgccttt aaggcctgtt ctcagcacaa tgtctcaaaa ataggtcata 120 tcctgccact cccgtcgcag agccctttaa tggttccaaa ccctaagtcc acacatagcc 180 cctggctctg gcatctctcc agccccactg gccccgagct gcttgactca ccggcttcct 240 atttgatgca cccaggcccc cttgtggcca actccctccc cttctcactg aggcagaagc 300 actgaggtgg gctggacatg ggtgccctcc acgtccctca tatccccagg cacactctgg 360 cctcaggttt tgccctggcc atgtcatcta cctggagtgg gccctcccct tcttcaggcc 420 ttgaatcaaa agccactttg ttaggcgagg atttcccaga ccactcatca cattaaaaaa 480 t 481 <210> 882 <211> 2589 <212> DNA <213> Homo sapiens <400> 882 gtttccctct gcgttcgctc cgcgctgctg gaggctgtcg tcccaatgct ccccaaacgg 60 cggcgagcgc gggtcgggtc ccctagcggc gatgccgctt cctccacgcc gccctcgacg 120 cgcttcccgg gagtcgccat ctacctggtc gagcctcgca tgggtcgcag ccgccgggcc 180 ttcctcacag gcctggcgcg ctccaaaggc ttccgcgtcc ttgacgcctg cagctccgaa 240 gcgacacatg ttgtgatgga agagacctca gcagaggagg ccgtcagctg gcaggagcgc 300 aggatggcag ctgctccccc gggttgcacc cccccagctc tgctggacat aagctggtta 360 acagagagcc tgggagctgg gcagcctgta cctgtggagt gccggcaccg cctggaggtg 420 gctgggccaa ggaaggggcc tctgagccca gcatggatgc ctgcctatgc ctgccagcgc 480 cctacgcccc tcacacacca caacactggc ctctccgagg ctctggagat actggccgag 540 gcagcaggct ttgaaggcag tgagggccgc ctcctcacct tctgcagagc agcctcggtg 600 ctcaaggccc ttcccagccc tgtcacaacc ctgagccagc tgcaggggct tccccacttt 660 ggagaacact cctctagggt tgtccaggag ctgctggagc atggagtgtg tgaggaggtg 720 gagagagttc ggcgctcaga gaggtaccag accatgaagc tcttcaccca gatcttcggg 780 gtcggtgtga agactgctga ccggtggtac cgggaaggac tgcgaacctt agatgacctc 840 cgagagcagc cccagaaact aacccaacag cagaaagcgg ggctccagca ccaccaggac 900 ctgagcaccc cagtcctgcg gtccgatgta gatgccctgc agcaggtggt ggaggaagct 960 gtggggcagg ccctgcctgg ggccaccgtc acgctgaccg gcggcttccg cagggggaag 1020 ttgcagggcc atgacgtgga cttcctcatc acccacccca aggagggtca ggaggcgggg 1080 ctgctgccta gagtgatgtg ccgcctgcag gaccagggcc tcatcctgta ccaccagcac 1140 cagcacagct gctgtgagtc ccctacccgc ctggcccaac agagccacat ggacgctttt 1200 gagagaagtt tctgcatttt ccgcctacca caacctccag gggctgctgt ggggggatcc 1260 acgaggccct gcccatcctg gaaggccgtg agagtggact tggtagttgc acccgtcagc 1320 cagttccctt tcgccctgct cggttggact ggctccaagc ttttccagcg ggagctgcgc 1380 cgcttcagcc ggaaggagaa gggcctgtgg ctgaacagcc atgggctgtt tgacccggag 1440 cagaagacat ttttccaagc ggcttcagag gaagacatct tcagacacct gggccttgag 1500 taccttcctc cagagcagag aaacgcctga acctgcctgt gtcccccact tccactcagg 1560 aaattgggct gcccccaaac tggccactga atgtctccaa gcaaatatgc tgccccctga 1620 ccccaccttc aaccctcccc gccaaggcct ggctcttccg gaggtcaatt gtgcctgcag 1680 gatcagttga gcccctgctg gtgtgctgca gggtgtgatg aggtgggagc cctcagtgcc 1740 agcctcatca ctgtgtgacc ctgggtctgc tcttagcctc cccatggctc acgttcctgc 1800 cctggatggg atgtgagtgg ggcccacatc gtggagctgt ggtggggcct gcagtcatga 1860 atggcaagtg gtccctgatg tgcagtgtct cattagttgc actgcagtta actgtggctc 1920 ctgcagggca ccctgcccag aatgcccaga agagaaccat gcatacctgc actgcatttg 1980 agagccatga gctggaggct gtggttcgtg ccagcaagga gcctactgtc tggtgtgctg 2040 taggcatctg gagagggaga gggcctgggt aggagctggg aggaagataa ttttcaacta 2100 tggggcttca gtactgcagc gccccgaagc caggctctgt gcttctgcct ttaaggcctg 2160 ttctcagcac aatgtctcaa aaataggtca tatcctgcca ctcccgtcgc agagcccttt 2220 aatggttcca aaccctaagt ccacacatag cccctggctc tggcatctct ccagccccac 2280 tggccccgag ctgcttgact caccggcttc ctatttgatg cacccaggcc cccttgtggc 2340 caactccctc cccttctcac tgaggcagaa gcactgaggt gggctggaca tgggtgccct 2400 ccacgtccct catatcccca ggcacactct ggcctcaggt tttgccctgg ccatgtcatc 2460 tacctggagt gggccctccc cttcttcagg ccttgaatca aaagccactt tgttaggcga 2520 ggatttccca gaccactcat cacattaaaa aatattttga aaacatgcag taaaaaaaaa 2580 aaaaaaaaa 2589 <210> 883 <211> 2561 <212> DNA <213> Homo sapiens <400> 883 tccctctgcg ttcgctccgc gctgctggag gctgtcgtcc caatgctccc caaacggcgg 60 cgagcgcggg tcgggtcccc tagcggcgat gccgcttcct ccacgccgcc ctcgacgcgc 120 ttcccgggag tcgccatcta cctggtcgag cctcgcatgg gtcgcagccg ccgggccttc 180 ctcacaggcc tggcgcgctc caaaggcttc cgcgtccttg acgcctgcag ctccgaagcg 240 acacatgttg tgatggaaga gacctcagca gaggaggccg tcagctggca ggagcgcagg 300 atggcagctg ctcccccggg ttgcaccccc ccagctctgc tggacataag ctggttaaca 360 gagagcctgg gagctgggca gcctgtacct gtggagtgcc ggcaccgcct ggaggtggct 420 gggccaagga aggggcctct gagcccagca tggatgcctg cctatgcctg ccagcgccct 480 acgcccctca cacaccacaa cactggcctc tccgaggctc tggagatact ggccgaggca 540 gcaggctttg aaggcagtga gggccgcctc ctcaccttct gcagagcagc ctcggtgctc 600 aaggcccttc ccagccctgt cacaaccctg agccagctgc aggggcttcc ccactttgga 660 gaacactcct ctagggttgt ccaggagctg ctggagcatg gagtgtgtga ggaggtggag 720 agagttcggc gctcagagag gtaccagacc atgaagctct tcacccagat cttcggggtc 780 ggtgtgaaga ctgctgaccg gtggtaccgg gaaggactgc gaaccttaga tgacctccga 840 gagcagcccc agaaactaac ccaacagcag aaagcggggc tccagcacca ccaggacctg 900 agcaccccag tcctgcggtc cgatgtagat gccctgcagc aggtggtgga ggaagctgtg 960 gggcaggccc tgcctggggc caccgtcacg ctgaccggcg gcttccgcag ggggaagttg 1020 cagggccatg acgtggactt cctcatcacc caccccaagg agggtcagga ggcggggctg 1080 ctgcctagag tgatgtgccg cctgcaggac cagggcctca tcctgtacca ccagcaccag 1140 cacagctgct gtgagtcccc tacccgcctg gcccaacaga gccacatgga cgcttttgag 1200 agaagtttct gcattttccg cctaccacaa cctccagggg ctgctgtggg gggatccacg 1260 aggccctgcc catcctggaa ggccgtgaga gtggacttgg tagttgcacc cgtcagccag 1320 ttccctttcg ccctgctcgg ttggactggc tccaagcttt tccagcggga gctgcgccgc 1380 ttcagccgga aggagaaggg cctgtggctg aacagccatg ggctgtttga cccggagcag 1440 aagacatttt tccaagcggc ttcagaggaa gacatcttca gacacctggg ccttgagtac 1500 cttcctccag agcagagaaa cgcctgagcc tgcctgtgtc ccccacttcc actcaggaaa 1560 ttgggctgcc cccaacctgg ccactgaatg tctccaggca gatatgctgc cccctgaccc 1620 ccaccttcac ccctccccgc caaggcctgg ctcttccgga ggtcaattgt gcctgcagga 1680 tcagttgagc ccctgctggt gtgctgcagg gtgtgatgag gtgggagccc tcagtgccag 1740 cctcatcact gtgtgaccct gggtctgctc ttagcctccc catggctcac gttcctgccc 1800 tggatgggat gtgagtgggg cccacatcgt ggagctgtgg tggggcctgc agtcatgaat 1860 ggcaagtggt ccctgatgtg cagtgtctca ttagttgcac tgcagttaac tgtggctcct 1920 gcagggcacc ctgcccagaa tgcccagaag agaaccatgc atacctgcac tgcatttgag 1980 agccatgagc tggaggctgt ggttcgtgcc agcaaggagc ctactgtctg gtgtgctgta 2040 ggcatctgga gagggagagg gcctgggtag gagctgggag gaagataatt ttcaactatg 2100 gggcttcagt actgcagcgc cccgagccag gctctgtgct tctgccttta aggcctgttc 2160 tcagcacaat gtctcaaaaa taggtcatat cctgccactc ccgtcgcaga gccctttaat 2220 ggttccaaac cctaagtcca cacatagccc ctggctctgg catctctcca gccccactgg 2280 ccccgagctg cttgactcac cggcttccta tttgatgcac ccaggccccc ttgtggccaa 2340 ctccctcccc ttctcactga ggcagaagca ctgaggtggg ctggacatgg gtgccctcca 2400 cgtccctcat atccccaggc acactctggc ctcaggtttt gccctggcca tgtcatctac 2460 ctggagtggg ccctcccctt cttcaggcct tgaatcaaaa gccactttgt taggcgagga 2520 tttcccagac cactcatcac attaaaaaat attttgaaaa c 2561 <210> 884 <211> 2562 <212> DNA <213> Homo sapiens <400> 884 actcactggg gcttccttcc gtctcgctcg gagtttccct ctgcgttcgc tccgcgctgc 60 tggaggctgt cgtcccaatg ctccccaaac ggcggcgagc gcgggtcggg tcccctagcg 120 gcgatgccgc ttcctccacg ccgccctcga cgcgcttccc gggagtcgcc atctacctgg 180 tcgagcctcg catgggtcgc agccgccggg ccttcctcac aggcctggcg cgctccaaag 240 gcttccgcgt ccttgacgcc tgcagctccg aagcgacaca tgttgtgatg gaagagacct 300 cagcagagga ggccgtcagc tggcaggagc gcaggatggc agctgctccc ccgggttgca 360 cccccccagc tctgctggac ataagctggt taacagagag cctgggagct gggcagcctg 420 tacctgtgga gtgccggcac cgcctggagg tggctgggcc aaggaagggg cctctgagcc 480 cagcatggat gcctgcctat gcctgccagc gccctacgcc cctcacacac cacaacactg 540 gcctctccga ggctctggag atactggccg aggcagcagg ctttgaaggc agtgagggcc 600 gcctcctcac cttctgcaga gcagcctcgg tgctcaaggc ccttcccagc cctgtcacaa 660 ccctgagcca gctgcagggg cttccccact ttggagaaca ctcctctagg gttgtccagg 720 agctgctgga gcatggagtg tgtgaggagg tggagagagt tcggcgctca gagagctctt 780 cacccagatc ttcggggtcg gtgtgaagac tgctgaccgg tggtaccggg aaggactgcg 840 aaccttagat gacctccgag agcagcccca gaaactaacc caacagcaga aagcggggct 900 ccagcaccac caggacctga gcaccccagt cctgcggtcc gatgtagatg ccctgcagca 960 ggtggtggag gaagctgtgg ggcaggccct gcctggggcc accgtcacgc tgaccggcgg 1020 cttccgcagg gccatgacgt ggacttcctc atcacccacc ccaaggaggg tcaggaggcg 1080 gggctgctgc ctagagtgat gtgccgcctg caggaccagg gcctcatcct gtaccaccag 1140 caccagcaca gctgctgtga gtcccctacc cgcctggccc aacagagcca catggacgct 1200 tttgagagaa gtttctgcat tttccgccta ccacaacctc caggggctgc tgtgggggga 1260 tccacgaggc cctgcccatc ctggaaggcc gtgagagtgg acttggtagt tgcacccgtc 1320 agccagttcc ctttcgccct gctcggttgg actggctcca agcttttcca gcgggagctg 1380 cgccgcttca gccggaagga gaagggcctg tggctgaaca gccatgggct gtttgacccg 1440 gagcagaaga catttttcca agcggcttca gaggaagaca tcttcagaca cctgggcctt 1500 gagtaccttc ctccagagca gagaaacgcc tgagcctgcc tgtgtcccca acttccactc 1560 aggaaattgg gctgccccca acctggccac tgaatgtctc caggcagata tgctgccccc 1620 tgacccccac cttcacccct ccccgccaag gcctggctct tccggaggtc aattgtgcct 1680 gcaggatcag ttgagcccct gctggtgtgc tgcagggtgt gatgaggtgg gagccctcag 1740 tgccagcctc atcactgtgt gaccctgggt ctgctcttag cctccccatg gctcacgttc 1800 ctgccctgga tgggatgtga gcggggccca catcgtggag ctgtggtggg gcctgcagtc 1860 atgaatggca agtggtccct gatgtgcagt gtcccattag ttgcactgca gttaactgtg 1920 gctcctgcag ggcaccctgc ccagaatgcc cagaagagaa ccatgcatac ctgcactgca 1980 tttgagagcc atgagctgga ggctgtggtt cgtgccagca aggagcctac tgtctggtgt 2040 gctgtaggca tctggagagg gagagggcct gggtaggagc tgggaggaag ataattttca 2100 actatggggc ttcagtactg cagcgccccg agccaggctc tgtgcttctg cctttaaggc 2160 ctgttctcag cacaatgtct caaaaatagg tcatatcctg ccactcccgt cgcagagccc 2220 tttaatggtt ccaaacccta agtccacaca tagcccctgg ctctggcatc tctccagccc 2280 cactggcccc gagctgcttg actcaccggc ttcctatttg atgcacccag gcccccttgt 2340 ggccaactcc ctccccttct cactgaggca gaagcactga ggtgggctgg acatgggtgc 2400 cctccacgtc ccccatatcc ccaggcacac tctggcctca ggttttgccc tggccatgtc 2460 atctacctgg agtgggccct ccccttcttc aggccttgaa tcaaaagcca ctttgttagg 2520 cgaggatttc ccagaccact catcacatta aaaaatattt tg 2562 <210> 885 <211> 2404 <212> DNA <213> Homo sapiens <400> 885 gctcggagtt tccctctgcg ttcgctccgc gctgctggag gctgtcgtcc caatgctccc 60 caaacggcgg cgagcgcggg tcgggtcccc tagcggcgat gccgcttcct ccacgccgcc 120 ctcgacgcgc ttcccgggag tcgccatcta cctggtcgag cctcgcatgg gtcgcagccg 180 ccgggccttc ctcacaggcc tggcgcgctc caaaggcttc cgcgtccttg acgcctgcag 240 ctccgaagcg acacatgttg tgatggaaga gacctcagca gaggaggccg tcagctggca 300 ggagcgcagg atggcagctg ctcccccggg ttgcaccccc ccagctctgc tggacataag 360 ctggttaaca gagagcctgg gagctgggca gcctgtacct gtggagtgcc ggcaccgcct 420 ggaggagctg ctggagcatg gagtgtgtga ggaggtggag agagttcggc gctcagagag 480 gtaccagacc atgaagggct ccagcaccac caggacctga gcaccccagt cctgcggtcc 540 gatgtagatg ccctgcagca ggtggtggag gaagctgtgg ggcaggccct gcctggggcc 600 accgtcacgc tgaccggcgg cttccgcagg taagaaggcc cgacgtgccc ctctggcttg 660 gcttcagacc cctccccagt gaagggacct gagtcgggga ccctgaagcg ggcccactcg 720 ttggaaggga tgtggcctgg ggctggagtg agcaggccgt gtccctgagt cagagtcaga 780 ctgacgccct cagggggaag ttgcagggcc atgacgtgga cttcctcatc acccacccca 840 aggagggtca ggaggcgggg ctgctgccta gagtgatgtg ccgcctgcag gaccagggcc 900 tcatcctgta ccaccagcac cagcacagct gctgtgagtc ccctacccgc ctggcccaac 960 agagccacat ggacgctttt gagagaagtt tctgcatttt ccgcctacca caacctccag 1020 gggctgctgt ggggggatcc acgaggccct gcccatcctg gaaggccgtg agagtggact 1080 tggtagttgc acccgtcagc cagttccctt tcgccctgct cggttggact ggctccaagc 1140 ttttccagcg ggagctgcgc cgcttcagcc ggaaggagaa gggcctgtgg ctgaacagcc 1200 atgggctgtt tgacccggag cagggaagca gcagtggcaa gactcctagg tcacggaagt 1260 cctgcttctg ttgcagaaga catttttcca agcggcttca gaggaagaca tcttcagaca 1320 cctgggcctt gagtaccttc ctccagagca gagaaacgcc tgagcctgcc tgtgtccccc 1380 acttccactc aggaaattgg gctgccccca acctggccac tgaatgtctc caggcagata 1440 tgctgccccc tgacccccac cttcacccct ccccgccaag gcctggctct tccggaggtc 1500 aattgtgcct gcaggatcag ttgagcccct gctggtgtgc tgcagggtgt gatgaggtgg 1560 gagccctcag tgccagcctc atcactgtgt gaccctgggt ctgctcttag cctccccatg 1620 gctcacgttc ctgccctgga tgggatgtga gtggggccca catcgtggag ctgtggtggg 1680 gcctgcagtc atgaatggca agtggtccct gatgtgcagt gtctcattag ttgcactgca 1740 gttaactgtg gctcctgcag ggcaccctgc ccagaatgcc cagaagagaa ccatgcatac 1800 ctgcactgca tttgagagcc atgagctgga ggctgtggtt cgtgccagca aggagcctac 1860 tgtctggtgt gctgtaggca tctggagagg gagagggcct gggtaggagc tgggaggaag 1920 ataattttca actatggggc ttcagtactg cagcgccccg agccaggctc tgtgcttctg 1980 cctttaaggc ctgttctcag cacaatgtct caaaaatagg tcatatcctg ccactcccgt 2040 cgcagagccc tttaatggtt ccaaacccta agtccacaca tagcccctgg ctctggcatc 2100 tctccagccc cactggcccc gagctgcttg actcaccggc ttcctatttg atgcacccag 2160 gcccccttgt ggccaactcc ctccccttct cactgaggca gaagcactga ggtgggctgg 2220 acatgggtgc cctccacgtc cctcatatcc ccaggcacac tctggcctca ggttttgccc 2280 tggccatgtc atctacctgg agtgggccct ccccttcttc aggccttgaa tcaaaagcca 2340 ctttgttagg cgaggatttc ccagaccact catcacatta aaaaatattt tgaaaacatg 2400 cagt 2404 <210> 886 <211> 2554 <212> DNA <213> Homo sapiens <400> 886 ggggtcttgg taatgttgcc taagctggtc tcaaacccct atgctcaaat gattctcctg 60 ccttggtccc caaaatgctg ggattatagg catgagccac ttcgctctgc cttgactgtt 120 tttgatggaa tattctcaag tagattacat gctgtggcat cttaaacaga gcactgtgaa 180 ccaaatgtac ccttgggtgc tgccactgag catgctgggc ttgcccttgc ccgccttctg 240 caggacctta tgtgttattt tctcagtgtt gtcagcctgc ctgtttccat ggccaccttc 300 cctctgtttc tgctcactcc tggtctgata gggaaatgcc gtctgagttc ttttggatgc 360 ctcgggtgtg cctgctttga cacccttctg ccaactggct ttgtggctgg aggtgtcaca 420 gcggtggcca catggataac tgtcagtgaa gtgtggcttc ctgggtggat ggggccttgg 480 gaggtcacac agaatgttgt caggattgac agggagggct tcgaagagga gagacttgag 540 cagtgtgtgc agggcaaatg ggctcaaata tgcagggaag ggggcaaggg gcactggcag 600 ggacagggga ccagatgagt ggggcaccgt ggtgagtgtg ggagtgaggg gcctgaagat 660 gatgaaatcc ccttgaagtg gtgtgaggtt agtgagtact ttcactgtca gcctcagccc 720 cagccctgaa ggcatctagg ctggcagaaa attacattag taatgagaag tttattaaca 780 atataattgg gttaatctca tcatttttag tcaggattct ttgggttgca agtgacagtg 840 acccacccca caccgttggt tcacaaaata aaggaaagga gggccagcag agcccaggat 900 ggggagggct gtggccggtc tgcaggacaa ctgggctcag cgacctgggt atcaccaggc 960 cactcctcct cccctctgcc cctctgcacg gtggcttcgc cctctcttgc gacgcaccag 1020 cttcttccat cggttggaaa tgtggccaca aaaggtgctc ggctgccaca ggctacagct 1080 tctgccactg tgtgggcctg ccctcagtct cagatccaga attcctaggg agggactcta 1140 gtggctgacc tgaagcaggt gacttgcttg ggctggggcc caccctctgt gggaagatat 1200 gtgagcaccc cagccagccc tgccaactct gctcctaaat ccaccctttt gattgttaac 1260 tcctcattgt tttttgctgt tggctaagga ggagaaccac agaaatttgt tccaccttct 1320 gttaggtggg agaggcatgg tttttccagt gacttaggag cccctcgtgc tgatgtgtta 1380 gggtgactgt tttgattatg ttggaatcac aggctagagc tgtgtaagtc cctttcatag 1440 aggagaggag aggggtgtgc gtgggtttgt tcccagagac ggcaggctgg gtagtcaggc 1500 tccaggtttg aatccttgcc ctgtggtcta cggcaggttg cgagtgggga cggcgcctgc 1560 ctggtgcatg gtgctccatg ggccacaccg tcccggagcg ggtgatcatc cgagtctagc 1620 catgagagct ctgcccaacc gggctacgct ccttccccac agctcttcac ccagatcttc 1680 ggggtcggtg tgaagactgc tgaccggtgg taccgggaag gactgcgaac cttagatgac 1740 ctccgagagc agccccagaa actaacccaa cagcagaaag cgggtgagcc ctccagagag 1800 gctgggccct gggcttccct aaactgcacc ctggatccct cagcatcaac tccctagagg 1860 gaagggagca gtctggtgca gagggtttgg tggcagcttt gtgtggtggg cttcctgggg 1920 tctccaccca gtgcagtcag gatctatcaa agccttttct cagtggacga tgctgaccac 1980 agcaacttcc atgatatgcc aggggcttgt gtctgcctac tggttagact ttgaccagtg 2040 accagggaca gcctgggcct tgggcacact gcccagtgtg gtgcttggta catggaggcc 2100 tgcagaggtg gcactgagca gcagaaagaa catcagcttt caagtttgtt aggcctgggt 2160 ttgagtctta tctaccattt gccaggtagg tgaccattgc ccaagaaata acctctctga 2220 gtctgttaca ttttctgtaa aatggagaag gaaggctggg catggtgact cacacctgta 2280 atcccagcac tttgggaggt caaggtgggt agatcgcttg agctcagcag ttcaagacca 2340 gtctgggcaa cagggtgaaa ccctgtctct acgagaaata caagagttag ccaggcgtga 2400 tggtggatgc ccgtagtacc agctactcat gaggccgagg tacaaggatc gctcgagccc 2460 gggaggtcaa gccttgaggc caaggtggaa gttgcaatga gctgagattg agccactgca 2520 ctccagcctg agtgacagag caagacccta tctc 2554 <210> 887 <211> 1653 <212> DNA <213> Homo sapiens <400> 887 cctctgcgtt cgctccgcgc tgctggaggc tgtcgtccca atgctcccca aacggcggcg 60 agcgcgggtc gggtccccta gcggcgatgc cgcttcctcc acgccgccct cgacgcgctt 120 cccgggagtc gccatctacc ttgtcgagcc tcgcatgggt cgcagccgcc gggccttcct 180 cacaggcctg gcgcgctcca aaggcttccg cgtccttgac gcctgcagct ccgaagcgac 240 acatgttgtg atggaagaga cctcagcaga ggaggccgtc agctggcagg agcgcaggat 300 ggcagctgct cccccgggtt gcaccccccc agctctgctg gacataagct ggttaacaga 360 gagcctggga gctgggcagc ctgtacctgt ggagtgccgg caccgcctgg aggtggctgg 420 gccaaggaag gggcctctga gcccagcatg gatgcctgcc tatgcctgcc agcgccctac 480 gcccctcaca caccacaaca ctggcctctc cgaggctctg gagatactgg ccgaggcagc 540 aggctttgaa ggcagtgagg gccgcctcct caccttctgc agagcagcct cggtgctcaa 600 ggcccttccc agccctgtca caaccctgag ccagctgcag gggcttcccc actttggaga 660 acactcctct agggttgtcc aggagctgct ggagcatgga gtgtgtgagg aggtggagag 720 agttcggcgc tcagagagct cttcacccag atcttcgggg tcggtgtgaa gactgctgac 780 cggtggtacc gggaaggact gcgaacctta gatgacctcc gagagcagcc ccagaaacta 840 acccaacagc agaaagcggg tgagccctcc agagaggctg ggccctgggc ttccctaaac 900 tgcaccctgg atccctcagc atcaactccc tagagggaag ggagcagtct ggtgcagagg 960 gtttggtggc agctttgtgt ggtgggcttc ctggggtctc cacccagtgc agtcaggatc 1020 tatcaaagcc ttttctcagt ggacgatgct gaccacagca acttccatga tatgccaggg 1080 gcttgtgtct gcctactggt tagactttga ccagtgacca gggacagcct gggccttggg 1140 cacactgccc agtgtggtgc ttggtacatg gaggcctgca gaggtggcac tgagcagcag 1200 aaagaacatc agctttcaag tttgttagtc ctgggtttga gtcttatcta ccatttgcca 1260 ggtaggtgac cattgcccaa gaaataacct ctctgagtct gttacatttt ctgtaaaatg 1320 gagaaggaag gctgggcatg gtgactcaca cctgtaatcc cagcactttg ggaggtcaag 1380 gtgggtagat cgcttgagct cagcagttca agaccagtct gggcaacagg gtgaaaccct 1440 gtctctacga gaaatacaag agttagccag gcgtgatggt ggatgcccgt agtaccagct 1500 actcatgagg ccgaggtaca aggatcgctc gagcccggga ggtcaagcct tgaggccaag 1560 gtggaagttg caatgagctg agattgagcc actgcactcc agcctgagtg acagagcaag 1620 accctatctc aaaaaaaaaa aaaaaaaaaa aaa 1653 <210> 888 <211> 2858 <212> DNA <213> Homo sapiens <400> 888 gtgcggaagg ggtgcccggg acgaagccat ggccctggag gcggcgggag ggccgccgga 60 ggaaacgctg tcactgtgga aacgggagca agctcggctg aaggcccacg tcgtagaccg 120 ggacaccgag gcgtggcagc gagaccccgc cttctcgggt ctgcagaggg tcgggggcgt 180 tgacgtgtcc ttcgtgaaag gggacagtgt ccgcgcttgt gcttccctgg tggtgctcag 240 cttccctgag ctcgaggtgg tgtatgagga gagccgcatg gtcagcctca cagcccccta 300 cgtgtcgggc ttcctggcct tccgagaggt gcccttcttg ctggagctgg tgcagcagct 360 gcgggagaag gagccgggcc tcatgcccca ggtccttctt gtggatggaa acggggtact 420 ccaccaccga ggctttgggg tggcctgcca ccttggcgtc cttacagacc tgccgtgtgt 480 tggggtggcc aagaaacttc tgcaggtgga tgggctggag aacaacgccc tgcacaagga 540 gaagatccga ctcctgcaga ctcgaggaga ctcattccct ctgctgggag actctgggac 600 tgtcctggga atggccctga ggagccacga ccgcagcacc aggcccctct acatctccgt 660 gggccacagg atgagcctgg aggccgctgt gcgcctgact tgctgctgct gcaggttccg 720 gatcccagag cccgtgcgcc aggctgacat ctgctcccga gagcacatcc gcaagtcgct 780 gggactcccc gggccaccca caccgaggag cccgaaggcg cagaggccag tggcatgccc 840 caaaggagac tccggagagt cctcagcact ttgttgaacg tggtggtgag agcacacgtc 900 ctcgtctcat tcctgatcga acgcggtggt gagagcacac gtcctcgtct cgttcctgat 960 cgaacgcggt ggtgagagca cacgtcctcg tctcgttcct gatcgaacgc ggtggtgaga 1020 gcacacgtcc tcgtctcgct cctgatcgaa cgcggtggtg agagcacacg tcctcgtctc 1080 gttcctgatc gaacgtggtg gtgagagcac acgtccttgt cttgttcctg atcttaaggg 1140 aacgtttgca gtctttcacc actagatgtg atgtgagctg ttagattttc aaggatgctc 1200 ttcatccagc tgaagacggt cccttctagt cctaatttgt taagtgtttt tatccttaaa 1260 gggtactgga ttttgtcaaa tgcttttctg gcctctattg aaaagatcct gtgttcttct 1320 gttaatatga ggtgttacat tgattgattt tcatatgttg agccagtttc catttgtgga 1380 atacatctaa ctcggtcatg gtgtataatc catttactct gctgctgaat gtgatttgct 1440 tgtattttgg tgcggatttt tacatctgta tttataaggg atattggtct ggtgttttct 1500 tatgatgtct tcctttggtt ttgatatcag gataatatta gcctcataga ttgggttagg 1560 aaatgttctc tcctccgttt tttttggaag agagagattg gtgttaattc ttgctagaac 1620 ctttggtaga atttgccagt aagcctatct ggtcttgggt ctttgggagg attttgattc 1680 gattcaatct atgtatttgt tatagatcgt tcggattgtc catccctgag tcagttgcta 1740 gcttgtgtgt ttcttggagt ttttccgttt cgtccatgtt atctcatctg ttggcatacc 1800 gtcgttcacg ggattttatt gatgtgtgtg aggtctctga gaacgtccct gccttcactc 1860 ctgcttttag tcactggcat cttcttttaa cttgggccat ctggccgtgc atggttttgg 1920 gagagtcctc cttgactctg cagatgctga gcagtgatct ggctgggaaa ggggaccagg 1980 agtgcagggc acctgctgag gactcaccta agcccaagag tcagagagtc ggagctccaa 2040 ccacatctgc ctgcatgcct ttcccaggct ctccccaggc ggacagccag caccccctcc 2100 ccaaagaccg ggcagttcct gaccagcacc ccaccaagtc ctcagtaagg cctgtctttg 2160 ggggagcagg gtttcaggag gacagtgggg gtggtgtaga actcatggct ggcggttccg 2220 ggcctctcag gaagctttgc cactgggctt ggggttaagt gggtgtgggg ctccgaaccc 2280 taaatgggtg agagttgaaa tgaaagcggc acctgtagtc cgtttggggt gcaggtgtgt 2340 gccaggggtc ttcagccccg gctgatggcc acatgaacca catgaggaga ggcagggcgt 2400 gtcagcagca aacctaagtg tgtgctcatt tctgtgggcc cttactctgt gacactgcag 2460 ctctccagag agacgctttg aaaacaaaac aggaaagaac acacggcccc gcgtctgttg 2520 cctgagtcac tgtattcctt aaaaggtgaa ggaccctggt ccttggcttt tcgtgcacat 2580 gagaaaatgt tggccaaggt tagcgattat gcttctgtaa tctgtaacca gaagtgctct 2640 tatgcccaaa ccttgatgtg attctgctgt aatgtaactt cggagccagc tggatggatg 2700 tgactgtgca ggtcctgagc cccggccccc gtaaccaagc agtgggccga gacactgagc 2760 cgggcagtca aacaggagct ctctaaggct gctcccgggc tgggacctgg gtctaggatt 2820 ctcagtaaga cctttgaata aaactaactt gaattctt 2858 <210> 889 <211> 2858 <212> DNA <213> Homo sapiens <400> 889 gtgcggaagg ggtgcccggg acgaagccat ggccctggag gcggcgggag ggccgccgga 60 ggaaacgctg tcactgtgga aacgggagca agctcggctg aaggcccacg tcgtagaccg 120 ggacaccgag gcgtggcagc gagaccccgc cttctcgggt ctgcagaggg tcgggggcgt 180 tgacgtgtcc ttcgtgaaag gggacagtgt ccgcgcttgt gcttccctgg tggtgctcag 240 cttccctgag ctcgaggtgg tgtatgagga gagccgcatg gtcagcctca cagcccccta 300 cgtgtcgggc ttcctggcct tccgagaggt gcccttcttg ctggagctgg tgcagcagct 360 gcgggagaag gagccgggcc tcatgcccca ggtccttctt gtggatggaa acggggtact 420 ccaccaccga ggctttgggg tggcctgcca ccttggcgtc cttacagacc tgccgtgtgt 480 tggggtggcc aagaaacttc tgcaggtgga tgggctggag aacaacgccc tgcacaagga 540 gaagatccga ctcctgcaga ctcgaggaga ctcattccct ctgctgggag actctgggac 600 tgtcctggga atggccctga ggagccacga ccgcagcacc aggcccctct acatctccgt 660 gggccacagg atgagcctgg aggccgctgt gcgcctgact tgctgctgct gcaggttccg 720 gatcccagag cccgtgcgcc aggctgacat ctgctcccga gagcacatcc gcaagtcgct 780 gggactcccc gggccaccca caccgaggag cccgaaggcg cagaggccag tggcatgccc 840 caaaggagac tccggagagt cctcagcact ttgttgaacg tggtggtgag agcacacgtc 900 ctcgtctcat tcctgatcga acgcggtggt gagagcacac gtcctcgtct cgttcctgat 960 cgaacgcggt ggtgagagca cacgtcctcg tctcgttcct gatcgaacgc ggtggtgaga 1020 gcacacgtcc tcgtctcgct cctgatcgaa cgcggtggtg agagcacacg tcctcgtctc 1080 gttcctgatc gaacgtggtg gtgagagcac acgtccttgt cttgttcctg atcttaaggg 1140 aacgtttgca gtctttcacc actagatgtg atgtgagctg ttagattttc aaggatgctc 1200 ttcatccagc tgaagacggt cccttctagt cctaatttgt taagtgtttt tatccttaaa 1260 gggtactgga ttttgtcaaa tgcttttctg gcctctattg aaaagatcct gtgttcttct 1320 gttaatatga ggtgttacat tgattgattt tcatatgttg agccagtttc catttgtgga 1380 atacatctaa ctcggtcatg gtgtataatc catttactct gctgctgaat gtgatttgct 1440 tgtattttgg tgcggatttt tacatctgta tttataaggg atattggtct ggtgttttct 1500 tatgatgtct tcctttggtt ttgatatcag gataatatta gcctcataga ttgggttagg 1560 aaatgttctc tcctccgttt tttttggaag agagagattg gtgttaattc ttgctagaac 1620 ctttggtaga atttgccagt aagcctatct ggtcttgggt ctttgggagg attttgattc 1680 gattcaatct atgtatttgt tatagatcgt tcggattgtc catccctgag tcagttgcta 1740 gcttgtgtgt ttcttggagt ttttccgttt cgtccatgtt atctcatctg ttggcatacc 1800 gtcgttcacg ggattttatt gatgtgtgtg aggtctctga gaacgtccct gccttcactc 1860 ctgcttttag tcactggcat cttcttttaa cttgggccat ctggccgtgc atggttttgg 1920 gagagtcctc cttgactctg cagatgctga gcagtgatct ggctgggaaa ggggaccagg 1980 agtgcagggc acctgctgag gactcaccta agcccaagag tcagagagtc ggagctccaa 2040 ccacatctgc ctgcatgcct ttcccaggct ctccccaggc ggacagccag caccccctcc 2100 ccaaagaccg ggcagttcct gaccagcacc ccaccaagtc ctcagtaagg cctgtctttg 2160 ggggagcagg gtttcaggag gacagtgggg gtggtgtaga actcatggct ggcggttccg 2220 ggcctctcag gaagctttgc cactgggctt ggggttaagt gggtgtgggg ctccgaaccc 2280 taaatgggtg agagttgaaa tgaaagcggc acctgtagtc cgtttggggt gcaggtgtgt 2340 gccaggggtc ttcagccccg gctgatggcc acatgaacca catgaggaga ggcagggcgt 2400 gtcagcagca aacctaagtg tgtgctcatt tctgtgggcc cttactctgt gacactgcag 2460 ctctccagag agacgctttg aaaacaaaac aggaaagaac acacggcccc gcgtctgttg 2520 cctgagtcac tgtattcctt aaaaggtgaa ggaccctggt ccttggcttt tcgtgcacat 2580 gagaaaatgt tggccaaggt tagcgattat gcttctgtaa tctgtaacca gaagtgctct 2640 tatgcccaaa ccttgatgtg attctgctgt aatgtaactt cggagccagc tggatggatg 2700 tgactgtgca ggtcctgagc cccggccccc gtaaccaagc agtgggccga gacactgagc 2760 cgggcagtca aacaggagct ctctaaggct gctcccgggc tgggacctgg gtctaggatt 2820 ctcagtaaga cctttgaata aaactaactt gaattctt 2858 <210> 890 <211> 2470 <212> DNA <213> Homo sapiens <400> 890 gtctggcctg cgcttgcgcg ggtctccgcc gcctgggctc ctagggactg tggcctcggc 60 ggtatgtccc ttgctttccc ttgaagcggg agaagacccg gcagaggcgc tctgtccgct 120 gcagccgcgc gggtggagga ggcagagtct gaggctttgg ggtggcctgc caccttggcg 180 tccttacaga cctgccgtgt gttggggtgg ccaagaaact tctgcaggtg gatgggctgg 240 agaacaacgc cctgcacaag gagaagatcc gactcctgca gactcgagga gactcattcc 300 ctctgctggg agactctggg actgtcctgg gaatggccct gaggagccac gaccgcagca 360 ccaggcccct ctacatctcc gtgggccaca ggatgagcct ggaggccgct gtgcgcctga 420 cttgctgctg ctgcaggttc cggatcccag agcccgtgcg ccagcacttt gttgaacgtg 480 gtggtgagag cacacgtcct cgtctcattc ctgatcgaac gcggtggtga gagcacacgt 540 cctcgtctcg ttcctgatcg aacgcggtgg tgagagcaca cgtcctcgtc tcgttcctga 600 tcgaacgcgg tggtgagagc acacgtcctc gtctcgttcc tgatcgaacg cggtggtgag 660 agcacacgtc ctcgtctcgt tcctgatcga acgtggtggt gagagcacac gtccttgtct 720 tgttcctgat cttaagggaa cgtttgcagt ctttcaccac tagatgtgat gtgagctgtt 780 agattttcaa ggatgctctt catccagctg aagacggtcc cttctagtcc taatttgtta 840 agtgttttta tccttaaagg gtactggatt ttgtcaaatg cttttctggc ctctattgaa 900 aagatcctgt gttcttctgt taatatgagg tgttacattg attgattttc atatgttgag 960 ccagtttcca tttgtggaat acatctaact cggtcatggt gtataatcca tttactctgc 1020 tgctgaatgt gatttgcttg tattttggtg cggattttta catctgtatt tataagggat 1080 attggtctgg tgttttctta tgatgtcttc ctttggtttt gatatcagga taatattagc 1140 ctcatagatt gggttaggaa atgttctctc ctccgttttt tttggaagag agagattggt 1200 gttaattctt gctagaacct ttggtagaat ttgccagtaa gcctatctgg tcttgggtct 1260 ttgggaggat tttgattcga ttcaatctat gtatttgtta tagatcgttc ggattgtcca 1320 tccttgagtc agttgctagc ttgtgtgttt cttggagttt ttccgtttcg tccatgttat 1380 ctcatctgtt ggcataccgt cgttcacagg attttattga tgtgtgtgag gtctctgaga 1440 acgtccctgc cttcactcct gcttttagtc actggcatct tcttttaact tgggccatct 1500 ggccgtgcat ggttttggga gagtcctcct tgactctgca gatgctgagc agtgatctgg 1560 ctgggaaagg ggaccaggag tgcagggcac ctgctgagga ctcacctaag cccaagagtg 1620 agagtcggag ctccaaccac atctgcctgc atgcctttcc caggctctcc ccaggcggac 1680 agccagcacc ccctccccaa agaccgggca gttcctgacc agcaccccac caagtcctca 1740 gtaaggcctg tctttggggg agcagggttt caggaggaca gtgggggtgg tgtagaactc 1800 atggctggcg gttccgggcc tctcaggaag ctttgccact gggcttgggg ttaagtgggt 1860 gtggggctcc gaaccctaaa tgggtgagag ttgaaatgaa agcggcacct gtagtccgtt 1920 tggggtgcag gtgtgtgcca ggggtcttca gcccaggctg atggccacat gaaccacatg 1980 aggagaggca gggcgtgtca gcagcaaacc taagtgtgtg ctcatttctg tgggccctta 2040 ctctgtgaca ctgcagctct ccagagagac gctttgaaaa caaaacagga aagaacacac 2100 ggccccgcgt ctgttgcctg agtcactgta ttccttaaaa ggtgaaggac cctggtcctt 2160 ggcttttcgt gcacatgaga aaatgttggc caaggttagc gattatgctt ctgtaatctg 2220 taaccagaag tgctcttatg cccaaacctt gatgtgattc tgctgtaatg taacttcgga 2280 gccagctgga tggatgtgac tgtgcaggtc ctgagccccg gcccccgtaa ccaagcagtg 2340 ggccgagaca ctgagccggg cagtcaaaca ggagctctct aaggctgctc ccgggctggg 2400 acctgggtct aggattctca gtaagacctt tgaataaaac taacttgaat tcttaaaaaa 2460 aaaaaaaaaa 2470 <210> 891 <211> 2607 <212> DNA <213> Homo sapiens <400> 891 cagtttgtct ggcctgcgct tgcgcgggtc tccgccgcct gggctcctag ggactgtggc 60 ctcggcggta tgtcccttgc tttcccttga agcgggagaa gacccggcag aggcgctctg 120 tccgctgcag ccgcgcgggt ggaggaggca gagtctgagg ctttggggtg gcctgccacc 180 ttggcgtcct tacagacctg ccgtgtgttg gggtggccaa gaaacttctg caggtggatg 240 ggctggagaa caacgccctg cacaaggaga agatccgact cctgcagact cgaggagact 300 cattccctct gctgggagac tctgggactg tcctgggaat ggccctgagg agccacgacc 360 gcagcaccag gcccctctac atctccgtgg gccacaggat gagcctggag gccgctgtgc 420 gcctgacttg ctgctgctgc aggttccgga tcccagagcc cgtgcgccag gctgacatct 480 gctcccgaga gcacatccgc aagtcgctgg gactccccgg gccacccaca ccgaggagcc 540 cgaaggcgca gaggccagtg gcatgcccca aaggagactc cggagagtcc tcagcacttt 600 gttgaacgtg gtggtgagag cacacgtcct cgtctcattc ctgatcgaac gcggtggtga 660 gagcacacgt cctcgtctcg ttcctgatcg aacgcggtgg tgagagcaca cgtcctcgtc 720 tcgttcctga tcgaacgcgg tggtgagagc acacgtcctc gtctcgttcc tgatcgaacg 780 cggtggtgag agcacacgtc ctcgtctcgt tcctgatcga acgtggtggt gagagcacac 840 gtccttgtct tgttcctgat cttaagggaa cgtttgcagt ctttcaccac tagatgtgat 900 gtgagctgtt agattttcaa ggatgctctt catccagctg aagacggtcc cttctagtcc 960 taatttgtta agtgttttta tccttaaagg gtactggatt ttgtcaaatg cttttctggc 1020 ctctattgaa aagatcctgt gttcttctgt taatatgagg tgttacattg attgattttc 1080 atatgttgag ccagtttcca tttgtggaat acatctaact cggtcatggt gtataatcca 1140 tttactctgc tgctgaatgt gatttgcttg tattttggtg cggattttta catctgtatt 1200 tataagggat attggtctgg tgttttctta tgatgtcttc ctttggtttt gatatcagga 1260 taatattagc ctcatagatt gggttaggaa atgttctctc ctccgttttt tttggaagag 1320 agagattggt gttaattctt gctagaacct ttggtagaat ttgccagtaa gcctatctgg 1380 tctagggtct ttgggaggat tttgattcga ttcaatctat gtatttgtta tagatcgttc 1440 ggattgtcca tccctgagtc agttgctagc ttgtgtgttt cttggagttt ttccgtttcg 1500 tccatgttat ctcatctgtt ggcataccgt cgttcacggg attttattga tgtgtgtgag 1560 gtctctgaga acgtccctgc cttcactcct gcttttagtc actggcatct tcttttaact 1620 tgggccatct ggccgtgcat ggttttggga gagtcctcct tgactctgca gatgctgagc 1680 agtgatctgg ctgggaaagg ggaccaggag tgcagggcac ctgctgagga ctcacctaag 1740 cccaagagtc agagagtcgg agctccaacc acatctgcct gcatgccttt cccaggctct 1800 ccccaggcgg acagccagca ccccctcccc aaagaccggg cagttcctga ccagcacccc 1860 accaagtcct cagtaaggcc tgtctttggg ggagcagggt ttcaggagga cagtgggggt 1920 ggtgtagaac tcatggctgg cggttccggg cctctcagga agctttgcca ctgggcttgg 1980 ggttaagtgg gtgtggggct ccgaacccta aatgggtgag agttgaaatg aaagcggcac 2040 ctgtagtccg tttggggtgc aggtgtgtgc caggggtctt cagccccggc tgatggccac 2100 atgaaccaca tgaggagagg cagggcgtgt cagcagcaaa cctaagtgtg tgctcatttc 2160 tgtgggccct tactctgtga cactgcagct ctccagagag acgctttgaa aacaaaacag 2220 gaaagaacac acggccccgc gtctgttgcc tgagtcactg tattccttaa aaggtgaagg 2280 accctggtcc ttggcttttc gtgcacatga gaaaatgttg gccaaggtta gcgattatgc 2340 ttctgtaatc tgtaaccaga agtgctctta tgcccaaacc ttgatgtgat tctgctgtaa 2400 tgtaacttcg gagccagctg gatggatgtg actgtgcagg tcctgagccc cggcccccgt 2460 aaccaagcag tgggccgaga cactgagccg ggcagtcaaa caggagctct ctaaggctgc 2520 tcccgggctg ggacctgggt ctaggattct cagtaagacc tttgaataaa actaacttga 2580 attcttcgaa aaaaaaaaaa aaaaaaa 2607 <210> 892 <211> 2543 <212> DNA <213> Homo sapiens <400> 892 cagtttgtct ggcctgcgct tgcgcgggtc tccgccgcct gggctcctag ggactgtggc 60 ctcggcggga gcaagctcgg ctgaaggccc acgtcgtaga ccgggacacc gaggcgtggc 120 agcgagaccc cgccttctcg ggtcttcaga gggtcggggg cgttgacgtg tccttcgtga 180 aaggggacag tgtccgcgct tgtgcttccc tggtggtgct cagcttccct gagctcgagg 240 ctttggggtg gcctgccacc ttggcgtcct tacagacctg ccgtgtgttg gggtggccaa 300 gaaacttctg caggtggatg ggctggagaa caacgccctg cacaaggaga agatccgact 360 cctgcagact cgaggagact cattccctct gctgggagac tctgggactg tcctgggaat 420 ggccctgagg agccacgacc gcagcaccag gcccctctac atctccgtgg gccacaggat 480 gagcctggag gccgctgtgc gcctgacttg ctgctgctgc aggttccgga tcccagagcc 540 cgtgcgccag cactttgttg aacgtggtgg tgagagcaca cgtcctcgtc tcattcctga 600 tcgaacgcgg tggtgagagc acacgtcctc gtctcgttcc tgatcgaacg cggtggtgag 660 agcacacgtc ctcgtctcgt tcctgatcga acgcggtggt gagagcacac gtcctcgtct 720 cgttcctgat cgaacgcggt ggtgagagca cacgtcctcg tctcgttcct gatcgaacgt 780 ggtggtgaga gcacacgtcc ttgtcttgtt cctgatctta agggaacgtt tgcagtcttt 840 caccactaga tgtgatgtga gctgttagat tttcaaggat gctcttcatc cagctgaaga 900 cggtcccttc tagtcctaat ttgttaagtg tttttatcct taaagggtac tggattttgt 960 caaatgcttt tctggcctct attgaaaaga tcctgtgttc ttctgttaat atgaggtgtt 1020 acattgattg attttcatat gttgagccag tttccatttg tggaatacat ctaactcggt 1080 catggtgtat aatccattta ctctgctgct gaatgtgatt tgcttgtatt ttggtgcgga 1140 tttttacatc tgtatttata agggatattg gtctggtgtt ttcttatgat gtcttccttt 1200 ggttttgata tcaggataat attagcctca tagattgggt taggaaatgt tctctcctcc 1260 gttttttttg gaagagagag attggtgtta attcttgcta gaacctttgg tagaatttgc 1320 cagtaagcct atctggtctt gggtctttgg gaggattttg attcgattca atctatgtat 1380 ttgttataga tcgttcggat tgtccatccc tgagtcagtt gctagcttgt gtgtttcttg 1440 gagtttttcc gtttcgtcca tgttatctca tctgttggca taccgtcgtt cacgggattt 1500 tattgatgtg tgtgaggtct ctgagaacgt ccctgccttc actcctgctt ttagtcactg 1560 gcatcttctt ttaacttggg ccatctggcc gtgcatggtt ttgggagagt cctccttgac 1620 tctgcagatg ctgagcagtg atctggctgg gaaaggggac caggagtgca gggcacctgc 1680 tgaggactca cctaagccca agagtcagag agtcggagct ccaaccacat ctgcctgcat 1740 gcctttccca ggctctcccc aggcggacag ccagcacccc ctccccaaag accgggcagt 1800 tcctgaccag caccccacca agtcctcagt aaggcctgtc tttgggggag cagggtttca 1860 ggaggacagt gggggtggtg tagaactcat ggctggcggt tccgggcctc tcaggaagct 1920 ttgccactgg gcttggggtt aagtgggtgt ggggctccga accctaaatg ggtgagagtt 1980 gaaatgaaag cggcacctgt agtccgtttg gggtgcaggt gtgtgccagg ggtcttcagc 2040 cccggctgat ggccacatga accacatgag gagaggcagg gcgtgtcagc agcaaaccta 2100 agtgtgtgct catttctgtg ggcccttact ctgtgacact gcagctctcc agagagacgc 2160 tttgaaaaca aaacaggaaa gaacacacgg ccccgcgtct gttgcctgag tcactgtatt 2220 ccttaaaagg tgaaggaccc tggtccttgg cttttcgtgc acatgagaaa atgttggcca 2280 aggttagcga ttatgcttct gtaatctgta accagaagtg ctcttatgcc caaaccttga 2340 tgtgattctg ctgtaatgta acttcggagc cagctggatg gatgtgactg tgcaggtcct 2400 gagccccggc ccccgtaacc aagcagtggg ccgagacact gagccgggca gtcaaacagg 2460 agctctctaa ggctgctccc gggctgggac ctgggtctag gattctcagt aagacctttg 2520 aataaaacta acttgaattc ttc 2543 <210> 893 <211> 890 <212> DNA <213> Homo sapiens <400> 893 gtgcccggga cgaagccatg gccctggagg cggcgggagg gccgccggag gaaacgctgt 60 cactgtggaa acgggagcaa gctcggctga aggcccacgt cgtagaccgg gacaccgagg 120 cgtggcagcg agaccccgcc ttctcgggtc tgcagagggt cgggggcgtt gacgtgtcct 180 tcgtgaaagg ggacagtgtc cgcgcttgtg cttccctggt ggtgctcagc ttccctgagc 240 tcgagttctg ccttcaggta gcaaaacaga acggatcttc cctgccttct gcttgtcagc 300 ccttctgctg ctggaaacag ctgcctgctc cttgaccaca ctgtcccaag aggctgcgat 360 gacgtccagc ttcttcactg gttcagctgt tgctgctctg gaatattctc tctcgcgcac 420 atgcgctctt tgtgtgcgtg tgtaccgtac atcccagcga ctgtgacagc tcagaagaca 480 tcagcaggcc tgtcctgaga atgacattct cctccacagc cacagtgtca ttatcatact 540 gattacacat catagtcatc ccataatgtc acctgaatga taacattatg ggagagattc 600 agatgtaagc agccacgccc ctcctgtggg aactcaggcc acacttgaat tccacatgtc 660 actgtgcaaa gtgactttta ctctgtgggg atgtcagtga tccagcctgc tggcttctct 720 gtgaacccaa attctgttat cagaatggac cctccccact ttgggtcatg ggcagatttg 780 atcagtttcc ccattgagtc attgatgaag atgttgtgag aatgatcccc aaccctctgt 840 gctaatacag agcactccgt ctgcaaaaaa aaaaaaaaaa aaaaaaaaaa 890 <210> 894 <211> 1265 <212> DNA <213> Homo sapiens <400> 894 gggacgaagc catggccctg gaggcggcgg gagggccgcc ggaggaaacg ctgtcactgt 60 ggaaacggga gcaagctcgg ctgaaggccc acgtcgtaga ccgggacacc gaggcgtggc 120 agcgagaccc cgccttctcg ggtctgcaga gggtcggggg cgttgacgtg tccttcgtga 180 aaggggacag tgtccgcgct tgtgcttccc tggtggtgct cagcttccct gagctcgagg 240 tccttcttgt ggatggaaac ggggtactcc accaccgagg ctttggggtg gcctgccacc 300 ttggcgtcct tacagacctg ccgtgtgttg gggtggccaa gaaacttctg caggtggatg 360 ggctggagaa caacgccctg cacaaggaga agatccgact cctgcagact cgaggagact 420 cattccctct gctgggagac tctgggactg tcctgggaat ggccctgagg agccacgacc 480 gcagcaccag gcccctctac atctccgtgg gccacaggat gagcctggag gccgctgtgc 540 gcctgacttg ctgctgctgc aggttccgga tcccagagcc cgtgcgccag gctgacatct 600 gctcccgaga gcacatccgc aagtcgctgg gactccccgg gccacccaca ccgaggagcc 660 cgaaggcgca gaggccagtg gcatgcccca aaggagactc cggagagtcc tcaggtgagg 720 gccagccccc acaggaccac agcccaggcc ccaggacagc cccaaggcca ggctcccagg 780 agcaggcggg caaggactgg cagtagggtg gaactgggca ccatgaagac aagaaggcca 840 ccggccaccc cgttctggcc tcaggacact gaccacccct gggggtggtc tagggactta 900 ggggaacctc atctcagccg caggtggagc acccagtccc caaagacagg ctgaccgcac 960 caccccaggg ggacgccgca gcacagccca gcaccaggtg gggcagaggt gaccacggcc 1020 cctctttgct ccgtcatcgg ctggtcagct gtggtcacgg tgcctcagag gacagatctc 1080 tatgggggca agtgccagat cctgagagcg catgagacgc tttcccggag ccgacgaagg 1140 ggactcggag ctgcagcctg cacgacccct gcagcctgtg ctttgcccac ccctttcaat 1200 agatggaact tgcttgctct tttttaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1260 aaaaa 1265 <210> 895 <211> 1475 <212> DNA <213> Homo sapiens <400> 895 cgagctcata gtcttcaggc tgtggaatcg gagctgccac cgcccgagac tccaaagcaa 60 agcccagttt ccggcgcgga agcggaggga tctcaggaat tgtagtccgc ggggtgggcg 120 cggttctcgc ttccggccag tttgtctggc ctgcgcttgc gcgggtctcc gccgcctggg 180 ctcctaggga ctgtggcctc ggcggtatgt cccttgcttt cccttgaagc gggagaagac 240 ccggcagagg cgctctgtcc gctgcagccg cgcgggtgga ggaggcagag tctgaggtgt 300 gaccccgacc aagtttgacg cttctgtcct cctagggagc aagctcggct gaaggcccac 360 gtcgtagacc gggacaccga ggcgtggcag cgagaccccg ccttctcggg tctgcagagg 420 gtcgggggcg ttgacgtgtc cttcgtgaaa ggggacagtg tccgcgcttg tgcttccctg 480 gtggtgctca gcttccctga gctcgaggtc cttcttgtgg atggaaacgg ggtactccac 540 caccgaggct ttggggtggc ctgccacctt ggcgtcctta cagacctgcc gtgtgttggg 600 gtggccaaga aacttctgca ggtggatggg ctggagaaca acgccctgca caaggagaag 660 atccgactcc tgcagactcg aggagactca ttccctctgc tgggagactc tgggactgtc 720 ctgggaatgg ccctgaggag ccacgaccgc agcaccaggc ccctctacat ctccgtgggc 780 cacaggatga gcctggaggc cgctgtgcgc ctgacttgct gctgctgcag gttccggatc 840 ccagagcccg tgcgccaggc tgacatctgc tcccgagagc acatccgcaa gtcgctggga 900 ctccccgggc cacccacacc gaggagcccg aaggcgcaga ggccagtggc atgccccaaa 960 ggagactccg gagagtcctc aggtgagggc cagcccccac aggaccacag cccaggcccc 1020 aggacagccc caaggccagg ctcccaggag caggcgggca aggactggca gtagggtgga 1080 actgggcacc atgaagacaa gaaggccacc ggccaccccg ttctggcctc aggacactga 1140 ccacccctgg gggtggtcta gggacttagg ggaacctcat ctcagccgca ggtggagcac 1200 ccagtcccca aagacaggct gaccgcacca ccccaggggg acgccgcagc acagcccagc 1260 accaggtggg gcagaggtga ccacggcccc tctttgctcc gtcatcggct ggtcagctgt 1320 ggtcacggtg cctcagagga cagatctcta tgggggcaag tgccagatcc tgagagcgca 1380 tgagacgctt tcccggagcc gacgaagggg actcggagct gcagcctgca cgacccctgc 1440 agcctgtgct ttgcccaccc ctttcaatag atgga 1475 <210> 896 <211> 1009 <212> DNA <213> Homo sapiens <400> 896 ccgggacgaa gccatggccc tggaggcggc gggagggccg ccggaggaaa cgctgtcact 60 gtggaaacgg taatgctgtc aggcgacgcg caggaggcgg gggccgaggc cgggcggccc 120 ttcgcggacc ctccgagctc atagtcttca ggctgtggaa tcggagctgc caccgcccga 180 gactccaaag caaagcccag tttccggcgc ggaagcggag ggatctcagg aattgtagtc 240 cgcggggtgg gcgcggttct cgcttccggc cagtttgtct ggcctgcgct tgcgcgggtc 300 tccgccgcct gggctcctag ggactgtggc ctcggcggta tgtcccttgc tttcccttga 360 agcgggagaa gacccggcag aggcgctctg tccgctgcag ccgcgcgggt ggaggaggca 420 gagtctgagg tgtgaccccg accaagtttg acgcttctgt cctcctaggg agcaagctcg 480 gctgaaggcc cacgtcgtag accgggacac cgaggcgtgg cagcgagacc ccgccttctc 540 gggtctgcag agggtcgggg gcgttgacgt gtccttcgtg aaaggggaca gtgtccgcgc 600 ttgtgcttcc ctggtggtgc tcagcttccc tgagctcgag gtaacctggg aggacgccga 660 gctcgaggcg ggcccctcgg tgggctcggg cgtgcggtct ccgggacagg gagcagtgca 720 agcgtagaac ccggcttctc gttttgtagg atgtcattaa tagtctgggg agttggccgg 780 gcgcggtggc tcacgcctgc aatcccagca ctttgggagg ctgaggcggg ggaatcacct 840 gaggtcggga gttcgagacc agcctgacca acatggagaa acccggtctc tactaaaaat 900 acaaaattag acgggtgtgg tggcatatac ctgtaatccc agctactcgg aaggctgagg 960 cgggagaatc gcttgaaccc gggaggcgga ggttgcggtg agccaacat 1009 <210> 897 <211> 1847 <212> DNA <213> Homo sapiens <400> 897 gcttgcgcgg gtctccgccg cctgggctcc tagggactgt ggcctcggcg gtatgtccct 60 tgctttccct tgaagcggga gaagacccgg cagaggcgct ctgtccgctg cagccgcgcg 120 ggtggaggag gcagagtctg aggtgtgacc ccgaccgagt ttgacgcttc tgtcctccta 180 gggagcaagc tcggctgaag gcccacgtcg tagaccggga caccgaggcg tggcagcgag 240 accccgcctt ctcgggtctg cagagggtcg ggggcgttga cgtgtccttc gtgaaagggg 300 acagtgtccg cgcttgtgct tccctggtgg tgctcagctt ccctgagctc gagtttagac 360 atgacgtcct ccactaagct ccctctcatc ccacaagacg aggacttgtc cctcagcacc 420 atgtcttagt ccgtttgggc tgctgtaata gaatacctta gactgggtgg cctacccaca 480 gcaggaattt atttctcaca gttctggagg ctggaggctc aagatcaggg tgccagcgca 540 atcaggttgt ggtgacggcg ctctttcagg ttgcacaggg ccagcttctt aaccgtgttc 600 tcacatggtg atccactcac ctccctagag gccccacctc gtaataccat cacctatggg 660 ttataatttc aacataggaa tttggggagg acaccagcat ttagaccgta gcaaccctct 720 gcttcctctt gtcttgctgg gatggaactg gcctgtcttc cctactggaa tataaactcc 780 atgatggtag aaaccatgtt gctttgccca ccatggatag catgaggaag acgctggact 840 cttccttcaa gagatacgtg tgtgaatgga cagtgggctc atgattcaca taagagtcaa 900 cagctccgga agcctcttgg cgtcactcgc attgctcctc tgctgactcc cgaaggtgac 960 aaacgtcttc ctgcttccat ggctttgtgc tttacttggg aggccctttt cagtccaaat 1020 caagcaaaaa tgtactgagt gcctactgtg tgctaagatt gggatattca gcagccccta 1080 ctctaagagg tcccctggcc attgtgtagg ctagcatagg gagtggggac acagtcttag 1140 ggtcctgact actcatgctc acacccaact ctgccactcc ccactttgcc ctctaggcct 1200 ctgtctcctt ttttctgact tgaggatgat agtggtatta atatccagct cacagaattg 1260 tgatgagcag tacatgaaat gcatggaaag cagttaacac agcattccct tccccctcca 1320 acttctcctg gctgcaaatt aatcacctca tctgcatcct gggcctcttt tgaatgcaca 1380 tgctgttaga gcgcttctca cattgtatta aagttagtca tttatgattc catttttccc 1440 actaactgta ggttctcaag agtagggtgt accatatttc ttttacaacc ccagcaccaa 1500 gcaaagcacc tgctacttcg tcggtattca ttgttccggc tatgaaagct tagactagga 1560 aaggatcttg gaacagtctg gtccactggt tcctgaatgc ccgaccgtgg acctgcagga 1620 gcagaatcac ccagaagtgt gttgagaaac agattccgta ggcacatcca cagagacaga 1680 aagtggatcc ttgggccttg gagttggggt gggatggatg ggaagtgact gctgatgagg 1740 atgaggttta tttaggggtt aaggaaaatg ttctaaagtt agattgtagt gatattgcac 1800 aactctgtaa ataccaaaac catcgcatta tatgttttaa acaagtg 1847 <210> 898 <211> 2592 <212> DNA <213> Homo sapiens <400> 898 cgcctgggct cctagggact gtggcctcgg cggtatgtcc cttgctttcc cttgaagcgg 60 gagaagaccc ggcagaggcg ctctgtccgc tgcagccgcg cgggtggagg aggcagagtc 120 tgaggtcctt cttgtggatg gaaacggggt actccaccac cgaggctttg gggtggcctg 180 ccaccttggc gtccttacag acctgccgtg tgttggggtg gccaagaaac ttctgcaggt 240 ggatgggctg gagaacaacg ccctgcacaa ggagaagatc cgactcctgc agactcgagg 300 agactcattc cctctgctgg gagactctgg gactgtcctg ggaatggccc tgaggagcca 360 cgaccgcagc accaggcccc tctacatctc cgtgggccac aggatgagcc tggaggccgc 420 tgtgcgcctg acttgctgct gctgcaggtt ccggatccca gagcccgtgc gccaggctga 480 catctgctcc cgagagcaca tccgcaagtc gctgggactc cccgggccac ccacaccgag 540 gagcccgaag gcgcagaggc cagtggcatg ccccaaagga gactccggag agtcctcagc 600 actttgttga acgtggtggt gagagcacac gtcctcgtct cattcctgat cgaacgcggt 660 ggtgagagca cacgtcctcg tctcgttcct gatcgaacgc ggtggtgaga gcacacgtcc 720 tcgtctcgtt cctgatcgaa cgcggtggtg agagcacacg tcctcgtctc gttcctgatc 780 gaacgcggtg gtgagagcac acgtcctcgt ctcgttcctg atcgaacgtg gtggtgagag 840 cacacgtcct tgtcttgttc ctgatcttaa gggaacgttt gcagtctttc accactagat 900 gtgatgtgag ctgttagatt ttcaaggatg ctcttcatcc agctgaagac ggtcccttct 960 agtcctaatt tgttaagtgt ttttatcctt aaagggtact ggattttgtc aaatgctttt 1020 ctggcctcta ttgaaaagat cctgtgttct tctgttaata tgaggtgtta cattgattga 1080 ttttcatatg ttgagccagt ttccatttgt ggaatacatc taactcggtc atggtgtata 1140 atccatttac tctgctgctg aatgtgattt gcttgtattt tggtgcggat ttttacatct 1200 gtatttataa gggatattgg tctggtgttt tcttatgatg tcttcctttg gttttgatat 1260 caggataata ttagcctcat agattgggtt aggaaatgtt ctctcctccg ttttttttgg 1320 aagagagaga ttggtgttaa ttcttgctag aacctttggt agaatttgcc agtaagccta 1380 tctggtcttg ggtctttggg aggattttga ttcgattcaa tctatgtatt tgttatagat 1440 cgttcggatt gtccatccct gagtcagttg ctagcttgtg tgtttcttgg agtttttccg 1500 tttcgtccat gttatctcat ctgttggcat accgtcgttc acgggatttt attgatgtgt 1560 gtgaggtctc tgagaacgtc cctgccttca ctcctgcttt tagtcactgg catcttcttt 1620 taacttgggc catctggccg tgcatggttt tgtgagagtc ctccttgact ctgcagatgc 1680 tgagcagtga tctggctggg aaaggggacc aggagtgcag ggcacctgct gaggactcac 1740 ctaagcccaa gagtcagaga gtcggagctc caaccacatc tgcctgcatg cctttcccag 1800 gctctcccca ggcggacagc cagcaccccc tccccaaaga ccgggcagtt cctgaccagc 1860 accccaccaa gtcctcagta aggcctgtct ttgggggagc agggtttcag gaggacagtg 1920 ggggtggtgt agaactcatg gctggcggtt ccgggcctct caggaagctt tgccactggg 1980 cttggggtta agtgggtgtg gggctccgaa ccctaaatgg gtgagagttg aaatgaaagc 2040 ggcacctgta gtccgtttgg ggtgcaggtg tgtgccaggg gtcttcagcc ccggctggtg 2100 gccacatgaa ccacatgagg agaggcaggg cgtgtcagca gcaaacctaa gtgtgtgctc 2160 atttctgtgg gcccttactc tgtgacactg cagctctcca gagagacgct ttgaaaacaa 2220 aacaggaaag aacacacggc cccgcgtctg ttgcctgagt cactgtattc cttaaaaggt 2280 gaaggaccct ggtccttggc ttttcgtgca catgagaaaa tgttggccaa ggttagcgat 2340 tatgcttctg taatctgtaa ccagaagtgc tcttatgccc aaaccttgat gtgattctgc 2400 tgtaatgtaa cttcggagcc agctggatgg atgtgactgt gcaggtcctg agccccggcc 2460 cccgtaacca agcagtgggc cgagacactg agccgggcag tcaaacagga gctctctaag 2520 gctgctcccg ggctgggacc tgggtctagg attctcagta agacctttga ataaaactaa 2580 cttgaattct tc 2592 <210> 899 <211> 2858 <212> DNA <213> Homo sapiens <400> 899 gtgcggaagg ggtgcccggg acgaagccat ggccctggag gcggcgggag ggccgccgga 60 ggaaacgctg tcactgtgga aacgggagca agctcggctg aaggcccacg tcgtagaccg 120 ggacaccgag gcgtggcagc gagaccccgc cttctcgggt ctgcagaggg tcgggggcgt 180 tgacgtgtcc ttcgtgaaag gggacagtgt ccgcgcttgt gcttccctgg tggtgctcag 240 cttccctgag ctcgaggtgg tgtatgagga gagccgcatg gtcagcctca cagcccccta 300 cgtgtcgggc ttcctggcct tccgagaggt gcccttcttg ctggagctgg tgcagcagct 360 gcgggagaag gagccgggcc tcatgcccca ggtccttctt gtggatggaa acggggtact 420 ccaccaccga ggctttgggg tggcctgcca ccttggcgtc cttacagacc tgccgtgtgt 480 tggggtggcc aagaaacttc tgcaggtgga tgggctggag aacaacgccc tgcacaagga 540 gaagatccga ctcctgcaga ctcgaggaga ctcattccct ctgctgggag actctgggac 600 tgtcctggga atggccctga ggagccacga ccgcagcacc aggcccctct acatctccgt 660 gggccacagg atgagcctgg aggccgctgt gcgcctgact tgctgctgct gcaggttccg 720 gatcccagag cccgtgcgcc aggctgacat ctgctcccga gagcacatcc gcaagtcgct 780 gggactcccc gggccaccca caccgaggag cccgaaggcg cagaggccag tggcatgccc 840 caaaggagac tccggagagt cctcagcact ttgttgaacg tggtggtgag agcacacgtc 900 ctcgtctcat tcctgatcga acgcggtggt gagagcacac gtcctcgtct cgttcctgat 960 cgaacgcggt ggtgagagca cacgtcctcg tctcgttcct gatcgaacgc ggtggtgaga 1020 gcacacgtcc tcgtctcgct cctgatcgaa cgcggtggtg agagcacacg tcctcgtctc 1080 gttcctgatc gaacgtggtg gtgagagcac acgtccttgt cttgttcctg atcttaaggg 1140 aacgtttgca gtctttcacc actagatgtg atgtgagctg ttagattttc aaggatgctc 1200 ttcatccagc tgaagacggt cccttctagt cctaatttgt taagtgtttt tatccttaaa 1260 gggtactgga ttttgtcaaa tgcttttctg gcctctattg aaaagatcct gtgttcttct 1320 gttaatatga ggtgttacat tgattgattt tcatatgttg agccagtttc catttgtgga 1380 atacatctaa ctcggtcatg gtgtataatc catttactct gctgctgaat gtgatttgct 1440 tgtattttgg tgcggatttt tacatctgta tttataaggg atattggtct ggtgttttct 1500 tatgatgtct tcctttggtt ttgatatcag gataatatta gcctcataga ttgggttagg 1560 aaatgttctc tcctccgttt tttttggaag agagagattg gtgttaattc ttgctagaac 1620 ctttggtaga atttgccagt aagcctatct ggtcttgggt ctttgggagg attttgattc 1680 gattcaatct atgtatttgt tatagatcgt tcggattgtc catccctgag tcagttgcta 1740 gcttgtgtgt ttcttggagt ttttccgttt cgtccatgtt atctcatctg ttggcatacc 1800 gtcgttcacg ggattttatt gatgtgtgtg aggtctctga gaacgtccct gccttcactc 1860 ctgcttttag tcactggcat cttcttttaa cttgggccat ctggccgtgc atggttttgg 1920 gagagtcctc cttgactctg cagatgctga gcagtgatct ggctgggaaa ggggaccagg 1980 agtgcagggc acctgctgag gactcaccta agcccaagag tcagagagtc ggagctccaa 2040 ccacatctgc ctgcatgcct ttcccaggct ctccccaggc ggacagccag caccccctcc 2100 ccaaagaccg ggcagttcct gaccagcacc ccaccaagtc ctcagtaagg cctgtctttg 2160 ggggagcagg gtttcaggag gacagtgggg gtggtgtaga actcatggct ggcggttccg 2220 ggcctctcag gaagctttgc cactgggctt ggggttaagt gggtgtgggg ctccgaaccc 2280 taaatgggtg agagttgaaa tgaaagcggc acctgtagtc cgtttggggt gcaggtgtgt 2340 gccaggggtc ttcagccccg gctgatggcc acatgaacca catgaggaga ggcagggcgt 2400 gtcagcagca aacctaagtg tgtgctcatt tctgtgggcc cttactctgt gacactgcag 2460 ctctccagag agacgctttg aaaacaaaac aggaaagaac acacggcccc gcgtctgttg 2520 cctgagtcac tgtattcctt aaaaggtgaa ggaccctggt ccttggcttt tcgtgcacat 2580 gagaaaatgt tggccaaggt tagcgattat gcttctgtaa tctgtaacca gaagtgctct 2640 tatgcccaaa ccttgatgtg attctgctgt aatgtaactt cggagccagc tggatggatg 2700 tgactgtgca ggtcctgagc cccggccccc gtaaccaagc agtgggccga gacactgagc 2760 cgggcagtca aacaggagct ctctaaggct gctcccgggc tgggacctgg gtctaggatt 2820 ctcagtaaga cctttgaata aaactaactt gaattctt 2858 <210> 900 <211> 2680 <212> DNA <213> Homo sapiens <400> 900 gtgcggaagg ggtgcccggg acgaagccat ggccctggag gcggcgggag ggccgccgga 60 ggaaacgctg tcactgtgga aatgggagca agctcggctg aaggcccacg tcgtagaccg 120 ggacaccgag gcgtggcagc gagaccccgc cttctcgggt ctgcagaggg tcgggggcgt 180 tgacgtgtcc ttcgtgaaag gggacagtgt ccgcgcttgt gcttccctgg tggtgctcag 240 cttccctgag ctcgaggtcc ttcttgtgga tggaaacggg gtactccacc accgaggctt 300 tggggtggcc tgccaccttg gcgtccttac agacctgccg tgtgttgggg tggccaagaa 360 acttctgcag gtggatgggc tggagaacaa cgccctgcac aaggagaaga tccgactcct 420 gcagactcga ggagactcat tccctctgct gggagactct gggactgtcc tgggaatggc 480 cctgaggagc cacgaccgca gcaccaggcc cctctacatc tccgtgggcc acaggatgag 540 cctggaggcc gctgtgcgcc tgacttgctg ctgctgcagg ttccggatcc cagagcccgt 600 gcgccaggct gacatctgct cccgagagca catccgcaag tcgctgggac tccccgggcc 660 acccacaccg aggagcccga aggcgcagag gccagtggca tgccccaaag gagactccgg 720 agagtcctca gcactttgtt gaacgtggtg gtgagagcac acgtcctcgt ctcattcctg 780 atcgaacgcg gtggtgagag cacacgtcct cgtctcgttc ctgatcgaac gcggtggtga 840 gagcacacat cctcgtctcg ttcctgatcg aacgcggtgg tgagagcaca cgtcctcgtc 900 tcgttcctga tcgaacgtgg tggtgagagc acacgtcctt gtcttgttcc tgatcttaag 960 ggaacgtttg cagtctttca ccactagatg tgatgtgagc tgttagattt tcaaggatgc 1020 tcttcatcca gctgaagacg gtcccttcta gtcctaattt gttaagtgtt tttatcctta 1080 aagggtactg gattttgtca aatgcttttc tggcctctat tgaaaagatc ctgtgttctt 1140 ctgtgaatat gaggtgttac attgattgat tttcatatgt tgagccagtt tccatttgtg 1200 gaatacatct aactcggtca tggtgtataa tccatttact ctgctgctga atgtgatttg 1260 cttgtatttt ggtgcggatt tttacatctg tatttataag ggatattggt ctggtgtttt 1320 cttatgatgt cttcctttgg ttttgatatc aggataatat tagcctcata gattgggtta 1380 ggaaatgttc tctcctccgt tttttttgga agagagagat tggtgttaat tcttgctaga 1440 acctttggta gaatttgcca gtaagcctat ctggtcttgg gtctttggga ggattttgat 1500 tcgattcaat ctatgtattt gttatagatc gttcggattg tccatccttg agtcagttgc 1560 tagcttgtgt gtttcttgga gtttttccgt ttcgtccatg ttatctcatc tgttggcata 1620 ccgtcgttca cgggatttta ttgatgtgtg tgaggtctct gagaacgtcc ctgccttcac 1680 tcctgctttt agtcactggc atcttctttt aacttgggcc atctggccgt gcatggtttt 1740 gggagagtcc tccttgactc tgcagatgct gagcagtgat ctggctggga aaggggacca 1800 ggagtgcagg gcacctgctg aggactcacc taagcccaag agtcagagag tcggagctcc 1860 aaccacatct gcctgcatgc ctttcccagg ctctccccag gcggacagcc agcaccccct 1920 ccccaaagac cgggcagttc ctgaccagca ccccaccaag tcctcagtaa ggcctgtctt 1980 tgggggagca gggtttcagg aggacagtgg gggtggtgta gaactcatgg ctggcggttc 2040 cgggcctctc aggaagcttt gccactgggc ttggggttaa gtgggtgtgg ggctccgaac 2100 cctaaatggg tgagagttga aatgaaagcg gcacctgtag tccgtttggg gtgcaggtgt 2160 gtgccagggg tcttcagccc cggctgatgg ccacatgaac cacatgagga gaggcagggc 2220 gtgtcagcag caaacctaag tgtgtgctca tttctgtggg cccttactct gtgacactgc 2280 agctctccag agagacgctt tgaaaacaaa acaggaaaga acacacggcc ccgcgtctgt 2340 tgcctgagtc actgtattcc ttaaaaggtg aaggaccctg gtccttggct tttcgtgcac 2400 atgagaaaat gttggccaag gttagcgatt atgcttctgt aatctgtaac cagaagtgct 2460 cttatgccca aaccttgatg tgattctgct gtaatgtaac ttcggagcca gctggatgga 2520 tgtgactgtg caggtcctga gccccggccc ccgtaaccaa gcagtgggcc gagacactga 2580 gccgggcagt caaacaggag ctctctaagg ctgctcccgg gctgggacct gggtctagga 2640 ttctcagtaa gacctttgaa taaaactaac ttgaattctt 2680 <210> 901 <211> 2470 <212> DNA <213> Homo sapiens <400> 901 gtctggcctg cgcttgcgcg ggtctccgcc gcctgggctc ctagggactg tggcctcggc 60 ggtatgtccc ttgctttccc ttgaagcggg agaagacccg gcagaggcgc tctgtccgct 120 gcagccgcgc gggtggagga ggcagagtct gaggctttgg ggtggcctgc caccttggcg 180 tccttacaga cctgccgtgt gttggggtgg ccaagaaact tctgcaggtg gatgggctgg 240 agaacaacgc cctgcacaag gagaagatcc gactcctgca gactcgagga gactcattcc 300 ctctgctggg agactctggg actgtcctgg gaatggccct gaggagccac gaccgcagca 360 ccaggcccct ctacatctcc gtgggccaca ggatgagcct ggaggccgct gtgcgcctga 420 cttgctgctg ctgcaggttc cggatcccag agcccgtgcg ccagcacttt gttgaacgtg 480 gtggtgagag cacacgtcct cgtctcattc ctgatcgaac gcggtggtga gagcacacgt 540 cctcgtctcg ttcctgatcg aacgcggtgg tgagagcaca cgtcctcgtc tcgttcctga 600 tcgaacgcgg tggtgagagc acacgtcctc gtctcgttcc tgatcgaacg cggtggtgag 660 agcacacgtc ctcgtctcgt tcctgatcga acgtggtggt gagagcacac gtccttgtct 720 tgttcctgat cttaagggaa cgtttgcagt ctttcaccac tagatgtgat gtgagctgtt 780 agattttcaa ggatgctctt catccagctg aagacggtcc cttctagtcc taatttgtta 840 agtgttttta tccttaaagg gtactggatt ttgtcaaatg cttttctggc ctctattgaa 900 aagatcctgt gttcttctgt taatatgagg tgttacattg attgattttc atatgttgag 960 ccagtttcca tttgtggaat acatctaact cggtcatggt gtataatcca tttactctgc 1020 tgctgaatgt gatttgcttg tattttggtg cggattttta catctgtatt tataagggat 1080 attggtctgg tgttttctta tgatgtcttc ctttggtttt gatatcagga taatattagc 1140 ctcatagatt gggttaggaa atgttctctc ctccgttttt tttggaagag agagattggt 1200 gttaattctt gctagaacct ttggtagaat ttgccagtaa gcctatctgg tcttgggtct 1260 ttgggaggat tttgattcga ttcaatctat gtatttgtta tagatcgttc ggattgtcca 1320 tccttgagtc agttgctagc ttgtgtgttt cttggagttt ttccgtttcg tccatgttat 1380 ctcatctgtt ggcataccgt cgttcacagg attttattga tgtgtgtgag gtctctgaga 1440 acgtccctgc cttcactcct gcttttagtc actggcatct tcttttaact tgggccatct 1500 ggccgtgcat ggttttggga gagtcctcct tgactctgca gatgctgagc agtgatctgg 1560 ctgggaaagg ggaccaggag tgcagggcac ctgctgagga ctcacctaag cccaagagtg 1620 agagtcggag ctccaaccac atctgcctgc atgcctttcc caggctctcc ccaggcggac 1680 agccagcacc ccctccccaa agaccgggca gttcctgacc agcaccccac caagtcctca 1740 gtaaggcctg tctttggggg agcagggttt caggaggaca gtgggggtgg tgtagaactc 1800 atggctggcg gttccgggcc tctcaggaag ctttgccact gggcttgggg ttaagtgggt 1860 gtggggctcc gaaccctaaa tgggtgagag ttgaaatgaa agcggcacct gtagtccgtt 1920 tggggtgcag gtgtgtgcca ggggtcttca gcccaggctg atggccacat gaaccacatg 1980 aggagaggca gggcgtgtca gcagcaaacc taagtgtgtg ctcatttctg tgggccctta 2040 ctctgtgaca ctgcagctct ccagagagac gctttgaaaa caaaacagga aagaacacac 2100 ggccccgcgt ctgttgcctg agtcactgta ttccttaaaa ggtgaaggac cctggtcctt 2160 ggcttttcgt gcacatgaga aaatgttggc caaggttagc gattatgctt ctgtaatctg 2220 taaccagaag tgctcttatg cccaaacctt gatgtgattc tgctgtaatg taacttcgga 2280 gccagctgga tggatgtgac tgtgcaggtc ctgagccccg gcccccgtaa ccaagcagtg 2340 ggccgagaca ctgagccggg cagtcaaaca ggagctctct aaggctgctc ccgggctggg 2400 acctgggtct aggattctca gtaagacctt tgaataaaac taacttgaat tcttaaaaaa 2460 aaaaaaaaaa 2470 <210> 902 <211> 2150 <212> DNA <213> Homo sapiens <400> 902 ctcgagccac gaaggccccg ctgtcctgtc tagcagatac ttgcacggtt tacagaaatt 60 cggtccctgg gtcgtgtcag gaaactggaa aaaaggtcat aagcatgaag cgcagttcag 120 tttccagcgg tggtgctggc cgcctctcca tgcaggagtt aagatcccag gatgtaaata 180 aacaaggcct ctatacccct caaaccaaag agaaaccaac ctttggaaag ttgagtataa 240 acaaaccgac atctgaaaga aaagtctcgc tatttggcaa aagaactagt ggacatggat 300 cccggaatag tcaacttggt atattttcca gttctgagaa aatcaaggac ccgagaccac 360 ttaatgacaa agcattcatt cagcagtgta ttcgacaact ctgtgagttt cttacagaaa 420 atggttatgc acataatgtg tccatgaaat ctctacaagc tccctctgtt aaagacttcc 480 tgaagatctt cacatttctt tatggcttcc tgtgcccctc atacgaactt cctgacacaa 540 agtttgaaga agaggttcca agaatcttta aagaccttgg gtatcctttt gcactatcca 600 aaagctccat gtacacagtg ggggctcctc atacatggcc tcacattgtg gcagccttag 660 tttggctaat agactgcatc aagatacata ctgccatgaa agaaagctca cctttatttg 720 atgatgggca gccttgggga gaagaaactg aagatggaat tatgcataat aagttgtttt 780 tggactacac cataaaatgc tatgagagtt ttatgagtgg tgccgacagc tttgatgaga 840 tgaatgcaga gctgcagtca aaactgaagg atttatttaa tgtggatgct tttaagctgg 900 aatcattaga agcaaaaaac agagcattga atgaacagat tgcaagattg gaacaagaaa 960 gagaaaaaga accgaatcgt ctagagtcgt tgagaaaact gaaggcttcc ttacaaggag 1020 atgttcaaaa gtatcaggca tacatgagca atttggagtc tcattcagcc attcttgacc 1080 agaaattaaa tggtctcaat gaggaaattg ctagagtaga actagaatgt gaaacaataa 1140 aacaggagaa cactcgacta cagaatatca ttgacaacca gaagtactca gttgcagaca 1200 ttgagcgaat aaatcatgaa agaaatgaat tgcagcagac tattaataaa ttaaccaagg 1260 acctggaagc tgaacaacag aagttgtgga atgaggagtt aaaatatgcc agaggcaaag 1320 aagcgattga aacacaatta gcagagtatc acaaattggc tagaaaatta aaacttattc 1380 ctaaaggtgc tgagaattcc aaaggttatg actttgaaat taagtttaat cccgaggctg 1440 gtgccaactg ccttgtcaaa tacagggctc aagtttatgt acctcttaag gaactcctga 1500 atgaaactga agaagaaatt aataaagccc taaataaaaa aatgggtttg gaggatactt 1560 tagaacaatt gaatgcaatg ataacagaaa gcaagagaag tgtgagaact ctgaaagaag 1620 aagttcaaaa gctggatgat ctttaccaac aaaaaattaa ggaagcagag gaagaggatg 1680 aaaaatgtgc cagtgagctt gagtccttgg agaaacacaa gcacctgcta gaaagtactg 1740 ttaaccaggg gctcagtgaa gctatgaatg aattagatgc tgttcagcgg gaataccaac 1800 tagttgtgca aaccacgact gaagaaagac gaaaagtggg aaataacttg caacgtctgt 1860 tagagatggt tgctacacat gttgggtctg tagagaaaca tcttgaggag cagattgcta 1920 aagttgatag agaatatgaa gaatgcatgt cagaagatct ctcggaaaat attaaagaga 1980 ttagagataa gtatgagaag aaagctactc taattaagtc ttctgaagaa tgaagataaa 2040 atgttgatca tgtatatata tccatagtga ataaaattgt ctcagtaaaa aaaaaaaaaa 2100 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2150 <210> 903 <211> 2150 <212> DNA <213> Homo sapiens <400> 903 ctcgagccac gaaggccccg ctgtcctgtc tagcagatac ttgcacggtt tacagaaatt 60 cggtccctgg gtcgtgtcag gaaactggaa aaaaggtcat aagcatgaag cgcagttcag 120 tttccagcgg tggtgctggc cgcctctcca tgcaggagtt aagatcccag gatgtaaata 180 aacaaggcct ctatacccct caaaccaaag agaaaccaac ctttggaaag ttgagtataa 240 acaaaccgac atctgaaaga aaagtctcgc tatttggcaa aagaactagt ggacatggat 300 cccggaatag tcaacttggt atattttcca gttctgagaa aatcaaggac ccgagaccac 360 ttaatgacaa agcattcatt cagcagtgta ttcgacaact ctgtgagttt cttacagaaa 420 atggttatgc acataatgtg tccatgaaat ctctacaagc tccctctgtt aaagacttcc 480 tgaagatctt cacatttctt tatggcttcc tgtgcccctc atacgaactt cctgacacaa 540 agtttgaaga agaggttcca agaatcttta aagaccttgg gtatcctttt gcactatcca 600 aaagctccat gtacacagtg ggggctcctc atacatggcc tcacattgtg gcagccttag 660 tttggctaat agactgcatc aagatacata ctgccatgaa agaaagctca cctttatttg 720 atgatgggca gccttgggga gaagaaactg aagatggaat tatgcataat aagttgtttt 780 tggactacac cataaaatgc tatgagagtt ttatgagtgg tgccgacagc tttgatgaga 840 tgaatgcaga gctgcagtca aaactgaagg atttatttaa tgtggatgct tttaagctgg 900 aatcattaga agcaaaaaac agagcattga atgaacagat tgcaagattg gaacaagaaa 960 gagaaaaaga accgaatcgt ctagagtcgt tgagaaaact gaaggcttcc ttacaaggag 1020 atgttcaaaa gtatcaggca tacatgagca atttggagtc tcattcagcc attcttgacc 1080 agaaattaaa tggtctcaat gaggaaattg ctagagtaga actagaatgt gaaacaataa 1140 aacaggagaa cactcgacta cagaatatca ttgacaacca gaagtactca gttgcagaca 1200 ttgagcgaat aaatcatgaa agaaatgaat tgcagcagac tattaataaa ttaaccaagg 1260 acctggaagc tgaacaacag aagttgtgga atgaggagtt aaaatatgcc agaggcaaag 1320 aagcgattga aacacaatta gcagagtatc acaaattggc tagaaaatta aaacttattc 1380 ctaaaggtgc tgagaattcc aaaggttatg actttgaaat taagtttaat cccgaggctg 1440 gtgccaactg ccttgtcaaa tacagggctc aagtttatgt acctcttaag gaactcctga 1500 atgaaactga agaagaaatt aataaagccc taaataaaaa aatgggtttg gaggatactt 1560 tagaacaatt gaatgcaatg ataacagaaa gcaagagaag tgtgagaact ctgaaagaag 1620 aagttcaaaa gctggatgat ctttaccaac aaaaaattaa ggaagcagag gaagaggatg 1680 aaaaatgtgc cagtgagctt gagtccttgg agaaacacaa gcacctgcta gaaagtactg 1740 ttaaccaggg gctcagtgaa gctatgaatg aattagatgc tgttcagcgg gaataccaac 1800 tagttgtgca aaccacgact gaagaaagac gaaaagtggg aaataacttg caacgtctgt 1860 tagagatggt tgctacacat gttgggtctg tagagaaaca tcttgaggag cagattgcta 1920 aagttgatag agaatatgaa gaatgcatgt cagaagatct ctcggaaaat attaaagaga 1980 ttagagataa gtatgagaag aaagctactc taattaagtc ttctgaagaa tgaagataaa 2040 atgttgatca tgtatatata tccatagtga ataaaattgt ctcagtaaaa aaaaaaaaaa 2100 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2150 <210> 904 <211> 2018 <212> DNA <213> Homo sapiens <400> 904 agatacttgc acggtttaca gaaattcggt ccctgggtcg tgtcaggaaa ctggaaaaaa 60 ggtcataagc atgaagcgca gttcagtttc cagcggtggt gctggccgcc tctccatgca 120 ggagttaaga tcccaggatg taaataaaca aggcctctat acccctcaaa ccaaagagaa 180 accaaccttt ggaaagttga gtataaacaa accgacatct gaaagaaaag tctcgctatt 240 tggcaaaaga actagtggac atggatcccg gaatagtcaa cttggtatat tttccagttc 300 tgagaaaatc aaggacccga gaccacttaa tgacaaagca ttcattcagc agtgtattcg 360 acaactctgt gagtttctta cagaaaatgg ttatgcacat aatgtgtcca tgaaatctct 420 acaagctccc tctgttaaag acttcctgaa gatcttcaca tttctttatg gcttcctgtg 480 cccctcatac gaacttcctg acacaaagtt tgaagaagag gttccaagaa tctttaaaga 540 ccttgggtat ccttttgcac tatccaaaag ctccatgtac acagtggggg ctcctcatac 600 atggcctcac attgtggcag ccttagtttg gctaatagac tgcatcaaga tacatactgc 660 catgaaagaa agctcacctt tatttgatga tgggcagcct tggggagaag aaactgaaga 720 tggaattatg cataataagt tgtttttgga ctacaccata aaatgctatg agagttttat 780 gagtggtgcc gacagctttg atgagatgaa tgcagagctg cagtcaaaac tgaaggattt 840 atttaatgtg gatgctttta agctggaatc attagaagca aaaaacagag cattgaatga 900 acagattgca agattggaac aagaaagaga aaaagaaccg aatcgtctag agtcgttgag 960 aaaactgaag gcttccttac aaggagatgt tcaaaagtat caggcataca tgagcaattt 1020 ggagtctcat tcagccattc ttgaccagaa attaaatggt ctcaatgagg aaattgctag 1080 agtagaacta gaatgtgaaa caataaaaca ggagaacact cgactacaga atatcattga 1140 caaccagaag tactcagttg cagacattga gcgaataaat catgaaagaa atgaattgca 1200 gcagactatt aataaattaa ccaaggacct ggaagctgaa caacagaagt tgtggaatga 1260 ggagttaaaa tatgccagag gcaaagaagc gattgaaaca caattagcag agtatcacaa 1320 attggctaga aaattaaaac ttattcctaa aggtgctgag aattccaaag gttatgactt 1380 tgaaattaag tttaatcccg aggctggtgc caactgcctt gtcaaataca gggctcaagt 1440 ttatgtacct cttaaggaac tcctgaatga aactgaagaa gaaattaata aagccctaaa 1500 taaaaaaatg ggtttggagg atactttaga acaattgaat gcaatgataa cagaaagcaa 1560 gagaagtgtg agaactctga aagaagaagt tcaaaagctg gatgatcttt accaacaaaa 1620 aattaaggaa gcagaggaag aggatgaaaa atgtgccagt gagcttgagt ccttggagaa 1680 acacaagcac ctgctagaaa gtactgttaa ccaggggctc agtgaagcta tgaatgaatt 1740 agatgctgtt cagcgggaat accaactagt tgtgcaaacc acgactgaag aaagacgaaa 1800 agtgggaaat aacttgcaac gtctgttaga gatggttgct acacatgttg ggtctgtaga 1860 gaaacatctt gaggagcaga ttgctaaagt tgatagagaa tatgaagaat gcatgtcaga 1920 agatctctcg gaaaatatta aagagattag agataagtat gagaagaaag ctactctaat 1980 taagtcttct gaagaatgaa gataaaatgt tgatcatg 2018 <210> 905 <211> 978 <212> DNA <213> Homo sapiens <400> 905 ggaaggacct ggtgttttga tgaccgctgt cctgtctagc agatacttgc acggtttaca 60 gaaattcggt ccctgggtcg tgtcaggaaa ctggaaaaaa ggtcataagc atgaagcgca 120 gttcagtttc cagcggtggt gctggccgcc tctccatgca ggagttaaga tcccaggatg 180 taaataaaca aggcctctat acccctcaaa ccaaagagaa accaaccttt ggaaagttga 240 gtataaacaa accgacatct gaaagaaaag tctcgctatt tggcaaaaga actagtggac 300 atggatcccg gaatagtcaa cttggtatat tttccagttc tgagaaaatc aaggacccga 360 gaccacttaa tgacaaagca ttcattcagc agtgtattcg ataactctgt gagtttctta 420 cagaaaatgg ttatgcacat aatgtgtcca tgaaatctct acaagctccc tctgttaaag 480 acttcctgaa gatcttcaca tttctttatg gcttcctgtg cccctcatac gaacttcctg 540 acacaaagtt tgaagaagag gttccaagaa tctttaaaga ccttgggtat ccttttgcac 600 tatccaaaag ctccatgtac acagtggggg ctcctcatac atggcctcac attgtggcag 660 ccttagtttg gctaatagac tgcatcaaga tacatactgc catgaaagaa agctcacctt 720 tatttgatga tgggcagcct tggggagaag aaactgaaga tggaattatg cataataagt 780 tgtttttgga ctacaccata aaatgctatg agagttttat gagtggtgcc gacagctttg 840 atgagatgaa tgcagagctg cagtcaaaac tgaaggattt atttaatgtg gatgctttta 900 agctggaatc attagaagca aaaaacagag cattgaatga acagattgca agattggaac 960 aaaaaaaaaa aaaaaaaa 978 <210> 906 <211> 1726 <212> DNA <213> Homo sapiens <400> 906 gccggcggag aatttcaaat tcgaacggct ttggcgggcc gaggaaggac ctggtgtttt 60 gatgaccgct gtcctgtcta gcagatactt gcacggttta cagaaattcg gtccctgggt 120 cgtgtcagga aactggaaaa aaggtcataa gcatgaagcg cagttcagtt tccagcggtg 180 gtgctggccg cctctccatg caggagttaa gatcccagga tgtaaataaa caaggcctct 240 atacccctca aaccaaagag aaaccaacct ttggaaagtt gagtataaac aaaccgacat 300 ctgaaagaaa agtctcgcta tttggcaaaa gaactagtgg acatggatcc cggaatagtc 360 aacttggtat attttccagt tctgagaaaa tcaaggaccc gagaccactt aatgacaaag 420 cattcattca gcagtgtatt cgacaactct gtgagtttct tacagaaaat ggttatgcac 480 ataatgtgtc catgaaatct ctacaagctc cctctgttaa agacttcctg aagatcttca 540 catttcttta tggcttcctg tgcccctcat acgaacttcc tgacacaaag tttgaagaag 600 aggtcccaag aatctttaaa gaccttgggt atccttttgc actatccaaa agctccatgt 660 acacagtggg ggctcctcat acatggcctc acattgtggc agccttagtt tggctaatag 720 actgcatcaa gatacatact gccatgaaag aaagctcacc tttatttgat gatgggcagc 780 cttggggaga agaaactgaa gatggaatta tgcataataa gttgtttttg gactacacca 840 taaaatgcta tgagagtttt atgagtggtg ccgacagctt tgatgagatg aatgcagagc 900 tgcagtcaaa actgaaggat ttatttaatg tggatgcttt taagctggaa tcattagaag 960 caaaaaacag agcattgaat gaacagattg caagattgga acaagaaaga gaaaaagaac 1020 cgaatcgtct agagtcgttg agaaaactga aggcttcctt acaaggagat gttcaaaagt 1080 atcaggcata catgagcaat ttggagtctc attcagccat tcttgaccag aaattaaatg 1140 gtctcaatga ggaaattgct agagtagaac tagaatgtga aacaataaaa caggagaaca 1200 ctcgactaca gaatatcatt gacaaccaga agtactcagt tgcagacatt gagcgaataa 1260 atcatgaaag aaatgaattg cagcagacta ttaataaatt aaccaaggac ctggaagctg 1320 aacaacagaa gttgtggaat gaggagttaa aatatgccag aggcaaagaa gcgattgaaa 1380 cacaattagc agagtatcac aaattggcta gaaaattaaa acttattcct aaaggtgctg 1440 agaattccaa aggttatgac tttgaaatta agtttaatcc cgaggctggt gccaactgcc 1500 ttgtcaaata cagggctcaa gtttatgtac ctcttaagga actcctgaat gaaactgaag 1560 aagaaattaa taaagcccta aataaaaaaa tgggtttgga ggatacttta gaacaattga 1620 atgcaatgat aacagaaagc aagagaagtg tgagaactct gaaagaagaa gttcaaaagc 1680 tggatgatct ttaccaacaa aaaaaaaaaa aaaaaaaaaa aaaaaa 1726 <210> 907 <211> 2140 <212> DNA <213> Homo sapiens <400> 907 cgaggaagga cctggtgttt tgatgaccgc tgtcctgtct agcagatact tgcacggttt 60 acagaaattc ggtccctggg tcgtgtcagg aaactggaaa aaaggtcata agcatgaagc 120 gcagttcagt ttccagcggt ggtgctggcc gcctctccat gcaggagtta agatcccagg 180 atgtaaataa acaaggcctc tatacccctc aaaccaaaga gaaaccaacc tttggaaagt 240 tgagtataaa caaaccgaca tctgaaagaa aagtctcgct atttggcaaa agaactagtg 300 gacatggatc ccggaatagt caacttggta tattttccag ttctgagaaa atcaaggacc 360 cgagaccact taatgacaaa gcattcattc agcagtgtat tcgacaactc tgtgagtttc 420 ttacagaaaa tggttatgca cataatgtgt ccatgaaatc tctacaagct ccctctgtta 480 aagacttcct gaagatcttc acatttcttt atggcttcct gtgcccctca tacgaacttc 540 ctgacacaaa gtttgaagaa gaggttccaa gaatctttaa agaccttggg tatccttttg 600 cactatccaa aagctccatg tacacagtgg gggctcctca tacatggcct cacattgtgg 660 cagccttagt ttggctaata gactgcatca agatacatac tgccatgaaa gaaagctcac 720 ctttatttga tgatgggcag ccttggggag aagaaactga agatggaatt atgcataata 780 agttgttttt ggactacacc ataaaatgct atgagagttt tatgagtggt gccgacagct 840 ttgatgagat gaatgcagag ctgcagtcaa aactgaagga tttatttaat gtggatgctt 900 ttaagctgga atcattagaa gcaaaaaaca gagcattgaa tgaacagatt gcaagattgg 960 aacaagaaag agaaaaagaa ccgaatcgtc tagagtcgtt gagaaaactg aaggcttcct 1020 tacaaggaga tgttcaaaag tatcaggcat acatgagcaa tttggagtct cattcagcca 1080 ttcttgacca gaaattaaat ggtctcaatg aggaaattgc tagagtagaa ctagaatgtg 1140 aaacaataaa acaggagaac actcgactac agaatatcat tgacaaccag aagtactcag 1200 ttgcagacat tgagcgaata aatcatgaaa gaaatgaatt gcagcagact attaataaat 1260 taaccaagga cctggaagct gaacaacaga agttgtggaa tgaggagtta aaatatgcca 1320 gaggcaaaga agcgattgaa acacaattag cagagtatca caaattggct agaaaattaa 1380 aacttattcc taaaggtgct gagaattcca aaggttatga ctttgaaatt aagtttaatc 1440 ccgaggctgg tgccaactgc cttgtcaaat acagggctca agtttatgta cctcttaagg 1500 aactcctgaa tgaaactgaa gaagaaatta ataaagccct aaataaaaaa atgggtttgg 1560 aggatacttt agaacaattg aatgcaatga taacagaaag caagagaagt gtgagaactc 1620 tgaaagaaga agttcaaaag ctggatgatc tttaccaaca aaaaattaag gaagcagagg 1680 aagaggatga aaaatgtgcc agtgagcttg agtccttgga gaaacacaag cacctgctag 1740 aaagtactgt taaccagggg ctcagtgaag ctatgaatga attagatgct gttcagcggg 1800 aataccaact agttgtgcaa accacgactg aagaaagacg aaaagtggga aataacttgc 1860 aacgtctgtt agagatggtt gctacacatg ttgggtctgt agagaaacat cttgaggagc 1920 agattgctaa agttgataga gaatatgaag aatgcatgtc agaagatctc tcggaaaata 1980 ttaaagagat tagagataag tatgagaaga aagctactct aattaagtct tctgaagaat 2040 gaagataaaa tgttgatcat gtatatatat ccatagtgaa taaaattgtc tcagtaaagt 2100 gtaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2140 <210> 908 <211> 2150 <212> DNA <213> Homo sapiens <400> 908 ctcgagccac gaaggccccg ctgtcctgtc tagcagatac ttgcacggtt tacagaaatt 60 cggtccctgg gtcgtgtcag gaaactggaa aaaaggtcat aagcatgaag cgcagttcag 120 tttccagcgg tggtgctggc cgcctctcca tgcaggagtt aagatcccag gatgtaaata 180 aacaaggcct ctatacccct caaaccaaag agaaaccaac ctttggaaag ttgagtataa 240 acaaaccgac atctgaaaga aaagtctcgc tatttggcaa aagaactagt ggacatggat 300 cccggaatag tcaacttggt atattttcca gttctgagaa aatcaaggac ccgagaccac 360 ttaatgacaa agcattcatt cagcagtgta ttcgacaact ctgtgagttt cttacagaaa 420 atggttatgc acataatgtg tccatgaaat ctctacaagc tccctctgtt aaagacttcc 480 tgaagatctt cacatttctt tatggcttcc tgtgcccctc atacgaactt cctgacacaa 540 agtttgaaga agaggttcca agaatcttta aagaccttgg gtatcctttt gcactatcca 600 aaagctccat gtacacagtg ggggctcctc atacatggcc tcacattgtg gcagccttag 660 tttggctaat agactgcatc aagatacata ctgccatgaa agaaagctca cctttatttg 720 atgatgggca gccttgggga gaagaaactg aagatggaat tatgcataat aagttgtttt 780 tggactacac cataaaatgc tatgagagtt ttatgagtgg tgccgacagc tttgatgaga 840 tgaatgcaga gctgcagtca aaactgaagg atttatttaa tgtggatgct tttaagctgg 900 aatcattaga agcaaaaaac agagcattga atgaacagat tgcaagattg gaacaagaaa 960 gagaaaaaga accgaatcgt ctagagtcgt tgagaaaact gaaggcttcc ttacaaggag 1020 atgttcaaaa gtatcaggca tacatgagca atttggagtc tcattcagcc attcttgacc 1080 agaaattaaa tggtctcaat gaggaaattg ctagagtaga actagaatgt gaaacaataa 1140 aacaggagaa cactcgacta cagaatatca ttgacaacca gaagtactca gttgcagaca 1200 ttgagcgaat aaatcatgaa agaaatgaat tgcagcagac tattaataaa ttaaccaagg 1260 acctggaagc tgaacaacag aagttgtgga atgaggagtt aaaatatgcc agaggcaaag 1320 aagcgattga aacacaatta gcagagtatc acaaattggc tagaaaatta aaacttattc 1380 ctaaaggtgc tgagaattcc aaaggttatg actttgaaat taagtttaat cccgaggctg 1440 gtgccaactg ccttgtcaaa tacagggctc aagtttatgt acctcttaag gaactcctga 1500 atgaaactga agaagaaatt aataaagccc taaataaaaa aatgggtttg gaggatactt 1560 tagaacaatt gaatgcaatg ataacagaaa gcaagagaag tgtgagaact ctgaaagaag 1620 aagttcaaaa gctggatgat ctttaccaac aaaaaattaa ggaagcagag gaagaggatg 1680 aaaaatgtgc cagtgagctt gagtccttgg agaaacacaa gcacctgcta gaaagtactg 1740 ttaaccaggg gctcagtgaa gctatgaatg aattagatgc tgttcagcgg gaataccaac 1800 tagttgtgca aaccacgact gaagaaagac gaaaagtggg aaataacttg caacgtctgt 1860 tagagatggt tgctacacat gttgggtctg tagagaaaca tcttgaggag cagattgcta 1920 aagttgatag agaatatgaa gaatgcatgt cagaagatct ctcggaaaat attaaagaga 1980 ttagagataa gtatgagaag aaagctactc taattaagtc ttctgaagaa tgaagataaa 2040 atgttgatca tgtatatata tccatagtga ataaaattgt ctcagtaaaa aaaaaaaaaa 2100 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2150 <210> 909 <211> 374 <212> PRT <213> Homo sapiens <400> 909 Ile Val Ser Leu Thr Gly Ile Gly Ser Gly Gln Ala Pro Leu Ala Gln 1 5 10 15 Cys Val Ala Leu Ala Gln Arg Pro Gly Val Arg Gln Gly Trp Leu Asn 20 25 30 Cys Gln Arg Leu Val Ile Asp Glu Ile Ser Met Val Glu Ala Asp Leu 35 40 45 Phe Asp Lys Leu Glu Ala Val Ala Arg Ala Val Arg Gln Gln Asn Lys 50 55 60 Pro Phe Gly Gly Ile Gln Leu Ile Ile Cys Gly Asp Phe Leu Gln Leu 65 70 75 80 Pro Pro Val Thr Lys Gly Ser Gln Pro Pro Arg Phe Cys Phe Gln Ser 85 90 95 Lys Ser Trp Lys Arg Cys Val Pro Val Thr Leu Glu Leu Thr Lys Val 100 105 110 Trp Arg Gln Ala Asp Gln Thr Phe Ile Ser Leu Leu Gln Ala Val Arg 115 120 125 Leu Gly Arg Cys Ser Asp Glu Val Thr Arg Gln Leu Gln Ala Thr Ala 130 135 140 Ser His Lys Val Gly Arg Asp Gly Ile Val Ala Thr Arg Leu Cys Thr 145 150 155 160 His Gln Asp Asp Val Ala Leu Thr Asn Glu Arg Arg Leu Gln Glu Leu 165 170 175 Pro Gly Lys Val His Arg Phe Glu Ala Met Asp Ser Asn Pro Glu Leu 180 185 190 Ala Ser Thr Leu Asp Ala Gln Cys Pro Val Ser Gln Leu Leu Gln Leu 195 200 205 Lys Leu Gly Ala Gln Val Met Leu Val Lys Asn Leu Ser Val Ser Arg 210 215 220 Gly Leu Val Asn Gly Ala Arg Gly Val Val Val Gly Phe Glu Ala Glu 225 230 235 240 Gly Arg Gly Leu Pro Gln Val Arg Phe Leu Cys Gly Val Thr Glu Val 245 250 255 Ile His Ala Asp Arg Trp Thr Val Gln Ala Thr Gly Gly Gln Leu Leu 260 265 270 Ser Arg Gln Gln Leu Pro Leu Gln Leu Ala Trp Ala Met Ser Ile His 275 280 285 Lys Ser Gln Gly Met Thr Leu Asp Cys Val Glu Ile Ser Leu Gly Arg 290 295 300 Val Phe Ala Ser Gly Gln Ala Tyr Val Ala Leu Ser Arg Ala Arg Ser 305 310 315 320 Leu Gln Gly Leu Arg Val Leu Asp Phe Asp Pro Met Ala Val Arg Cys 325 330 335 Asp Pro Arg Val Leu His Phe Tyr Ala Thr Leu Arg Arg Gly Arg Ser 340 345 350 Leu Ser Leu Glu Ser Pro Asp Asp Asp Glu Ala Ala Ser Asp Gln Glu 355 360 365 Asn Met Asp Pro Asn Leu 370 <210> 910 <211> 266 <212> PRT <213> Homo sapiens <400> 910 Met Leu Ser Gly Ile Glu Ala Ala Ala Gly Glu Tyr Glu Asp Ser Glu 1 5 10 15 Leu Arg Cys Arg Val Ala Val Glu Glu Leu Ser Pro Gly Gly Gln Pro 20 25 30 Arg Arg Arg Gln Ala Leu Arg Thr Ala Glu Leu Ser Leu Gly Arg Asn 35 40 45 Glu Arg Arg Glu Leu Met Leu Arg Leu Gln Ala Pro Gly Pro Ala Gly 50 55 60 Arg Pro Arg Cys Phe Pro Leu Arg Ala Ala Arg Leu Phe Thr Arg Phe 65 70 75 80 Ala Glu Ala Gly Arg Ser Thr Leu Arg Leu Pro Ala His Asp Thr Pro 85 90 95 Gly Ala Gly Ala Val Gln Leu Leu Leu Ser Asp Cys Pro Pro Asp Arg 100 105 110 Leu Arg Arg Phe Leu Arg Thr Leu Arg Leu Lys Leu Ala Ala Ala Pro 115 120 125 Gly Pro Gly Pro Ala Ser Ala Arg Ala Gln Leu Leu Gly Pro Arg Pro 130 135 140 Arg Asp Phe Val Thr Ile Ser Pro Val Gln Pro Glu Glu Arg Arg Leu 145 150 155 160 Arg Ala Ala Thr Arg Val Pro Asp Thr Thr Leu Val Lys Arg Pro Val 165 170 175 Glu Pro Gln Ala Gly Ala Glu Pro Ser Thr Glu Ala Pro Arg Trp Pro 180 185 190 Leu Pro Val Lys Arg Leu Ser Leu Pro Ser Thr Lys Pro Gln Leu Ser 195 200 205 Glu Glu Gln Ala Ala Val Leu Arg Ala Val Leu Lys Gly Gln Ser Ile 210 215 220 Phe Phe Thr Gly Ser Ala Gly Ser Gly Gly Arg Glu Glu Val Gly Gly 225 230 235 240 Gln Trp Trp Gly Gly Ile Glu Glu Gln Gly Asp Leu Ser Asn Phe Ala 245 250 255 Pro Val Gln Glu Gln Gly Ser His Ile Cys 260 265 <210> 911 <211> 266 <212> PRT <213> Homo sapiens <400> 911 Met Leu Ser Gly Ile Glu Ala Ala Ala Gly Glu Tyr Glu Asp Ser Glu 1 5 10 15 Leu Arg Cys Arg Val Ala Val Glu Glu Leu Ser Pro Gly Gly Gln Pro 20 25 30 Arg Arg Arg Gln Ala Leu Arg Thr Ala Glu Leu Ser Leu Gly Arg Asn 35 40 45 Glu Arg Arg Glu Leu Met Leu Arg Leu Gln Ala Pro Gly Pro Ala Gly 50 55 60 Arg Pro Arg Cys Phe Pro Leu Arg Ala Ala Arg Leu Phe Thr Arg Phe 65 70 75 80 Ala Glu Ala Gly Arg Ser Thr Leu Arg Leu Pro Ala His Asp Thr Pro 85 90 95 Gly Ala Gly Ala Val Gln Leu Leu Leu Ser Asp Cys Pro Pro Asp Arg 100 105 110 Leu Arg Arg Phe Leu Arg Thr Leu Arg Leu Lys Leu Ala Ala Ala Pro 115 120 125 Gly Pro Gly Pro Ala Ser Ala Arg Ala Gln Leu Leu Gly Pro Arg Pro 130 135 140 Arg Asp Phe Val Thr Ile Ser Pro Val Gln Pro Glu Glu Arg Arg Leu 145 150 155 160 Arg Ala Ala Thr Arg Val Pro Asp Thr Thr Leu Val Lys Arg Pro Val 165 170 175 Glu Pro Gln Ala Gly Ala Glu Pro Ser Thr Glu Ala Pro Arg Trp Pro 180 185 190 Leu Pro Val Lys Arg Leu Ser Leu Pro Ser Thr Lys Pro Gln Leu Ser 195 200 205 Glu Glu Gln Ala Ala Val Leu Arg Ala Val Leu Lys Gly Gln Ser Ile 210 215 220 Phe Phe Thr Gly Ser Ala Gly Ser Gly Gly Arg Glu Glu Val Gly Gly 225 230 235 240 Gln Trp Trp Gly Gly Ile Glu Glu Gln Gly Asp Leu Ser Asn Phe Ala 245 250 255 Pro Val Gln Glu Gln Gly Ser His Ile Cys 260 265 <210> 912 <211> 570 <212> PRT <213> Homo sapiens <400> 912 Met Ala Leu Lys Lys Ser Ser Pro Ser Leu Asp Ser Gly Asp Ser Asp 1 5 10 15 Ser Glu Glu Leu Pro Thr Phe Ala Phe Leu Lys Lys Glu Pro Ser Ser 20 25 30 Thr Lys Arg Arg Gln Pro Glu Arg Glu Glu Lys Ile Val Val Val Asp 35 40 45 Ile Ser Asp Cys Glu Ala Ser Cys Pro Pro Ala Pro Glu Leu Phe Ser 50 55 60 Pro Pro Val Pro Asp Ile Ala Glu Thr Val Thr Gln Thr Gln Pro Val 65 70 75 80 Arg Leu Leu Ser Ser Glu Ser Glu Asp Glu Glu Glu Phe Ile Pro Leu 85 90 95 Ala Gln Arg Leu Thr Cys Lys Phe Leu Thr His Lys Gln Leu Ser Pro 100 105 110 Glu Asp Ser Ser Ser Pro Val Lys Ser Val Leu Asp His Gln Asn Asn 115 120 125 Glu Gly Ala Ser Cys Asp Trp Lys Lys Pro Phe Pro Lys Ile Pro Glu 130 135 140 Val Pro Leu His Asp Thr Pro Glu Arg Ser Ala Ala Asp Asn Lys Asp 145 150 155 160 Leu Ile Leu Asp Pro Cys Cys Gln Leu Pro Ala Tyr Leu Ser Thr Cys 165 170 175 Pro Gly Gln Ser Ser Ser Leu Ala Val Thr Lys Thr Asn Ser Asp Ile 180 185 190 Leu Pro Pro Gln Lys Lys Thr Lys Pro Ser Gln Lys Val Gln Gly Arg 195 200 205 Gly Ser His Gly Cys Gln Gln Gln Arg Gln Ala Arg Gln Lys Glu Ser 210 215 220 Thr Leu Arg Arg Gln Glu Arg Lys Asn Ala Ala Leu Val Thr Arg Met 225 230 235 240 Lys Ala Gln Arg Pro Glu Glu Cys Leu Lys His Ile Ile Val Val Leu 245 250 255 Asp Pro Val Leu Leu Gln Met Glu Gly Gly Gly Gln Leu Leu Gly Ala 260 265 270 Leu Gln Thr Met Glu Cys Arg Cys Val Ile Glu Ala Gln Ala Val Pro 275 280 285 Cys Ser Val Thr Trp Arg Arg Arg Ala Gly Pro Ser Glu Asp Arg Glu 290 295 300 Asp Trp Val Glu Glu Pro Thr Val Leu Val Leu Leu Arg Ala Glu Ala 305 310 315 320 Phe Val Ser Met Ile Asp Asn Gly Lys Gln Gly Ser Leu Asp Ser Thr 325 330 335 Met Lys Gly Lys Glu Thr Leu Gln Gly Phe Val Thr Asp Ile Thr Ala 340 345 350 Lys Thr Ala Gly Lys Ala Leu Ser Leu Val Ile Val Asp Gln Glu Lys 355 360 365 Cys Phe Ser Ala Gln Asn Pro Pro Arg Arg Gly Lys Gln Gly Ala Asn 370 375 380 Lys Gln Thr Lys Lys Gln Gln Gln Arg Gln Pro Glu Ala Ser Ile Gly 385 390 395 400 Ser Met Val Ser Arg Val Asp Ala Glu Glu Ala Leu Val Asp Leu Gln 405 410 415 Leu His Thr Glu Ala Gln Ala Gln Ile Val Gln Ser Trp Lys Glu Leu 420 425 430 Ala Asp Phe Thr Cys Ala Phe Thr Lys Ala Val Ala Glu Ala Pro Phe 435 440 445 Lys Lys Leu Arg Asp Glu Thr Thr Phe Ser Phe Cys Leu Glu Ser Asp 450 455 460 Trp Ala Gly Gly Val Lys Val Asp Leu Ala Gly Arg Gly Leu Ala Leu 465 470 475 480 Val Trp Arg Arg Gln Ile Gln Gln Leu Asn Arg Val Ser Leu Glu Met 485 490 495 Ala Ser Ala Val Val Asn Ala Tyr Pro Ser Pro Gln Leu Leu Val Gln 500 505 510 Ala Tyr Gln Gln Cys Phe Ser Asp Lys Glu Arg Gln Asn Leu Leu Ala 515 520 525 Asp Ile Gln Val Arg Arg Gly Glu Gly Val Thr Ser Thr Ser Arg Arg 530 535 540 Ile Gly Pro Glu Leu Ser Arg Arg Ile Tyr Leu Gln Met Thr Thr Leu 545 550 555 560 Gln Pro His Leu Ser Leu Asp Ser Ala Asp 565 570 <210> 913 <211> 583 <212> PRT <213> Homo sapiens <400> 913 Met Ala Leu Lys Lys Ser Ser Pro Ser Leu Asp Ser Gly Asp Ser Asp 1 5 10 15 Ser Glu Glu Leu Pro Thr Phe Ala Phe Leu Lys Lys Glu Pro Ser Ser 20 25 30 Thr Lys Arg Arg Gln Pro Glu Arg Glu Glu Lys Ile Val Val Val Asp 35 40 45 Ile Ser Asp Cys Glu Ala Ser Cys Pro Pro Ala Pro Glu Leu Phe Ser 50 55 60 Pro Pro Val Pro Asp Ile Ala Glu Thr Val Thr Gln Thr Gln Pro Val 65 70 75 80 Arg Leu Leu Ser Ser Glu Ser Glu Asp Glu Glu Glu Phe Ile Pro Leu 85 90 95 Ala Gln Arg Leu Thr Cys Lys Phe Leu Thr His Lys Gln Leu Ser Pro 100 105 110 Glu Asp Ser Ser Ser Pro Val Lys Ser Val Leu Asp His Gln Asn Asn 115 120 125 Glu Gly Ala Ser Cys Asp Trp Lys Lys Pro Phe Pro Lys Ile Pro Glu 130 135 140 Val Pro Leu His Asp Thr Pro Glu Arg Ser Ala Ala Asp Asn Lys Asp 145 150 155 160 Leu Ile Leu Asp Pro Cys Cys Gln Leu Pro Ala Tyr Leu Ser Thr Cys 165 170 175 Pro Gly Gln Ser Ser Ser Leu Ala Val Thr Lys Thr Asn Ser Asp Ile 180 185 190 Leu Pro Pro Gln Lys Lys Thr Lys Pro Ser Gln Lys Val Gln Gly Arg 195 200 205 Gly Ser His Gly Cys Arg Gln Gln Arg Gln Ala Arg Gln Lys Glu Ser 210 215 220 Thr Leu Arg Arg Gln Glu Arg Lys Asn Ala Ala Leu Val Thr Arg Met 225 230 235 240 Lys Ala Gln Arg Pro Glu Glu Cys Leu Lys His Ile Ile Val Val Leu 245 250 255 Asp Pro Val Leu Leu Gln Met Glu Gly Gly Gly Gln Leu Leu Gly Ala 260 265 270 Leu Gln Thr Met Glu Cys Arg Cys Val Ile Glu Ala Gln Ala Val Pro 275 280 285 Cys Ser Val Thr Trp Arg Arg Arg Ala Gly Pro Ser Glu Asp Arg Glu 290 295 300 Asp Trp Val Glu Glu Pro Thr Val Leu Val Leu Leu Arg Ala Glu Ala 305 310 315 320 Phe Val Ser Met Ile Asp Asn Gly Lys Gln Gly Ser Leu Asp Ser Thr 325 330 335 Met Lys Gly Lys Glu Thr Leu Gln Gly Phe Val Thr Asp Ile Thr Ala 340 345 350 Lys Thr Ala Gly Lys Ala Leu Ser Leu Val Ile Val Asp Gln Glu Lys 355 360 365 Cys Phe Ser Leu Glu Leu Leu Phe Phe Asp Phe Leu Pro Cys Thr Ser 370 375 380 Ala Gln Asn Pro Pro Arg Arg Gly Lys Gln Gly Ala Asn Lys Gln Thr 385 390 395 400 Lys Lys Gln Gln Gln Arg Gln Pro Glu Ala Ser Ile Gly Ser Met Val 405 410 415 Ser Arg Val Asp Ala Glu Glu Ala Leu Val Asp Leu Gln Leu His Thr 420 425 430 Glu Ala Gln Ala Gln Ile Val Gln Ser Trp Lys Glu Leu Ala Asp Phe 435 440 445 Thr Cys Ala Phe Thr Lys Ala Val Ala Glu Ala Pro Phe Lys Lys Leu 450 455 460 Arg Asp Glu Thr Thr Phe Ser Phe Cys Leu Glu Ser Asp Trp Ala Gly 465 470 475 480 Gly Val Lys Val Asp Leu Ala Gly Arg Gly Leu Ala Leu Val Trp Arg 485 490 495 Arg Gln Ile Gln Gln Leu Asn Arg Val Ser Leu Glu Met Ala Ser Ala 500 505 510 Val Val Asn Ala Tyr Pro Ser Pro Gln Leu Leu Val Gln Ala Tyr Gln 515 520 525 Gln Cys Phe Ser Asp Lys Glu Arg Gln Asn Leu Leu Ala Asp Ile Gln 530 535 540 Val Arg Arg Gly Glu Gly Val Thr Ser Thr Ser Arg Arg Ile Gly Pro 545 550 555 560 Glu Leu Ser Arg Arg Ile Tyr Leu Gln Met Thr Thr Leu Gln Pro His 565 570 575 Leu Ser Leu Asp Ser Ala Asp 580 <210> 914 <211> 570 <212> PRT <213> Homo sapiens <400> 914 Met Ala Leu Lys Lys Ser Ser Pro Ser Leu Asp Ser Gly Asp Ser Asp 1 5 10 15 Ser Glu Glu Leu Pro Thr Phe Ala Phe Leu Lys Lys Glu Pro Ser Ser 20 25 30 Thr Lys Arg Arg Gln Pro Glu Arg Glu Glu Lys Ile Val Val Val Asp 35 40 45 Ile Ser Asp Cys Glu Ala Ser Cys Pro Pro Ala Pro Glu Leu Phe Ser 50 55 60 Pro Pro Val Pro Asp Ile Ala Glu Thr Val Thr Gln Thr Gln Pro Val 65 70 75 80 Arg Leu Leu Ser Ser Glu Ser Glu Asp Glu Glu Glu Phe Ile Pro Leu 85 90 95 Ala Gln Arg Leu Thr Cys Lys Phe Leu Thr His Lys Gln Leu Ser Pro 100 105 110 Glu Asp Ser Ser Ser Pro Val Lys Ser Val Leu Asp His Gln Asn Asn 115 120 125 Glu Gly Ala Ser Cys Asp Trp Lys Lys Pro Phe Pro Lys Ile Pro Glu 130 135 140 Val Pro Leu His Asp Thr Pro Glu Arg Ser Ala Ala Asp Asn Lys Asp 145 150 155 160 Leu Ile Leu Asp Pro Cys Cys Gln Leu Pro Ala Tyr Leu Ser Thr Cys 165 170 175 Pro Gly Gln Ser Ser Ser Leu Ala Val Thr Lys Thr Asn Ser Asp Ile 180 185 190 Leu Pro Pro Gln Lys Lys Thr Lys Pro Ser Gln Lys Val Gln Gly Arg 195 200 205 Gly Ser His Gly Cys Gln Gln Gln Arg Gln Ala Arg Gln Lys Glu Ser 210 215 220 Thr Leu Arg Arg Gln Glu Arg Lys Asn Ala Ala Leu Val Thr Arg Met 225 230 235 240 Lys Ala Gln Arg Pro Glu Glu Cys Leu Lys His Ile Ile Val Val Leu 245 250 255 Asp Pro Val Leu Leu Gln Met Glu Gly Gly Gly Gln Leu Leu Gly Ala 260 265 270 Leu Gln Thr Met Glu Cys Arg Cys Val Ile Glu Ala Gln Ala Val Pro 275 280 285 Cys Ser Val Thr Trp Arg Arg Arg Ala Gly Pro Ser Glu Asp Arg Glu 290 295 300 Asp Trp Val Glu Glu Pro Thr Val Leu Val Leu Leu Arg Ala Glu Ala 305 310 315 320 Phe Val Ser Met Ile Asp Asn Gly Lys Gln Gly Ser Leu Asp Ser Thr 325 330 335 Met Lys Gly Lys Glu Thr Leu Gln Gly Phe Val Thr Asp Ile Thr Ala 340 345 350 Lys Thr Ala Gly Lys Ala Leu Ser Leu Val Ile Val Asp Gln Glu Lys 355 360 365 Cys Phe Ser Ala Gln Asn Pro Pro Arg Arg Gly Lys Gln Gly Ala Asn 370 375 380 Lys Gln Thr Lys Lys Gln Gln Gln Arg Gln Pro Glu Ala Ser Ile Gly 385 390 395 400 Ser Met Val Ser Arg Val Asp Ala Glu Glu Ala Leu Val Asp Leu Gln 405 410 415 Leu His Thr Glu Ala Gln Ala Gln Ile Val Gln Ser Trp Lys Glu Leu 420 425 430 Ala Asp Phe Thr Cys Ala Phe Thr Lys Ala Val Ala Glu Ala Pro Phe 435 440 445 Lys Lys Leu Arg Asp Glu Thr Thr Phe Ser Phe Cys Leu Glu Ser Asp 450 455 460 Trp Ala Gly Gly Val Lys Val Asp Leu Ala Gly Arg Gly Leu Ala Leu 465 470 475 480 Val Trp Arg Arg Gln Ile Gln Gln Leu Asn Arg Val Ser Leu Glu Met 485 490 495 Ala Ser Ala Val Val Asn Ala Tyr Pro Ser Pro Gln Leu Leu Val Gln 500 505 510 Ala Tyr Gln Gln Cys Phe Ser Asp Lys Glu Arg Gln Asn Leu Leu Ala 515 520 525 Asp Ile Gln Val Arg Arg Gly Glu Gly Val Thr Ser Thr Ser Arg Arg 530 535 540 Ile Gly Pro Glu Leu Ser Arg Arg Ile Tyr Leu Gln Met Thr Thr Leu 545 550 555 560 Gln Pro His Leu Ser Leu Asp Ser Ala Asp 565 570 <210> 915 <211> 1001 <212> PRT <213> Homo sapiens <400> 915 Met Ile Phe Pro Val Ala Arg Tyr Ala Leu Arg Trp Leu Arg Arg Pro 1 5 10 15 Glu Asp Arg Ala Phe Ser Arg Ala Ala Met Glu Met Ala Leu Arg Gly 20 25 30 Val Arg Lys Val Leu Cys Val Ala Glu Lys Asn Asp Ala Ala Lys Gly 35 40 45 Ile Ala Asp Leu Leu Ser Asn Gly Arg Met Arg Arg Arg Glu Gly Leu 50 55 60 Ser Lys Phe Asn Lys Ile Tyr Glu Phe Asp Tyr His Leu Tyr Gly Gln 65 70 75 80 Asn Val Thr Met Val Met Thr Ser Val Ser Gly His Leu Leu Ala His 85 90 95 Asp Phe Gln Met Gln Phe Arg Lys Trp Gln Ser Cys Asn Pro Leu Val 100 105 110 Leu Phe Glu Ala Glu Ile Glu Lys Tyr Cys Pro Glu Asn Phe Val Asp 115 120 125 Ile Lys Lys Thr Leu Glu Arg Glu Thr Arg Gln Cys Gln Ala Leu Val 130 135 140 Ile Trp Thr Asp Cys Asp Arg Glu Gly Glu Asn Ile Gly Phe Glu Ile 145 150 155 160 Ile His Val Cys Lys Ala Val Lys Pro Asn Leu Gln Val Leu Arg Ala 165 170 175 Arg Phe Ser Glu Ile Thr Pro His Ala Val Arg Thr Ala Cys Glu Asn 180 185 190 Leu Thr Glu Pro Asp Gln Arg Val Ser Asp Ala Val Asp Val Arg Gln 195 200 205 Glu Leu Asp Leu Arg Ile Gly Ala Ala Phe Thr Arg Phe Gln Thr Leu 210 215 220 Arg Leu Gln Arg Ile Phe Pro Glu Val Leu Ala Glu Gln Leu Ile Ser 225 230 235 240 Tyr Gly Ser Cys Gln Phe Pro Thr Leu Gly Phe Val Val Glu Arg Phe 245 250 255 Lys Ala Ile Gln Ala Phe Val Pro Glu Ile Phe His Arg Ile Lys Val 260 265 270 Thr His Asp His Lys Asp Gly Ile Val Glu Phe Asn Trp Lys Arg His 275 280 285 Arg Leu Phe Asn His Thr Ala Cys Leu Val Leu Tyr Gln Leu Cys Val 290 295 300 Glu Asp Pro Met Ala Thr Val Val Glu Val Arg Ser Lys Pro Lys Ser 305 310 315 320 Lys Trp Arg Pro Gln Ala Leu Asp Thr Val Glu Leu Glu Lys Leu Ala 325 330 335 Ser Arg Lys Leu Arg Ile Asn Ala Lys Glu Thr Met Arg Ile Ala Glu 340 345 350 Lys Leu Tyr Thr Gln Gly Tyr Ile Ser Tyr Pro Arg Thr Glu Thr Asn 355 360 365 Ile Phe Pro Arg Asp Leu Asn Leu Thr Val Leu Val Glu Gln Gln Thr 370 375 380 Pro Asp Pro Arg Trp Gly Ala Phe Ala Gln Ser Ile Leu Glu Arg Gly 385 390 395 400 Gly Pro Thr Pro Arg Asn Gly Asn Lys Ser Asp Gln Ala His Pro Pro 405 410 415 Ile His Pro Thr Lys Tyr Thr Asn Asn Leu Gln Gly Asp Glu Gln Arg 420 425 430 Leu Tyr Glu Phe Ile Val Arg His Phe Leu Ala Cys Cys Ser Gln Asp 435 440 445 Ala Gln Gly Gln Glu Thr Thr Val Glu Ile Asp Ile Ala Gln Glu Arg 450 455 460 Phe Val Ala His Gly Leu Met Ile Leu Ala Arg Asn Tyr Leu Asp Val 465 470 475 480 Tyr Pro Tyr Asp His Trp Ser Asp Lys Ile Leu Pro Val Tyr Glu Gln 485 490 495 Gly Ser His Phe Gln Pro Ser Thr Val Glu Met Val Asp Gly Glu Thr 500 505 510 Ser Pro Pro Lys Leu Leu Thr Glu Ala Asp Leu Ile Ala Leu Met Glu 515 520 525 Lys His Gly Ile Gly Thr Asp Ala Thr His Ala Glu His Ile Glu Thr 530 535 540 Ile Lys Ala Arg Met Tyr Val Gly Leu Thr Pro Asp Lys Arg Phe Leu 545 550 555 560 Pro Gly His Leu Gly Met Gly Leu Val Glu Gly Tyr Asp Ser Met Gly 565 570 575 Tyr Glu Met Ser Lys Pro Asp Leu Arg Ala Glu Leu Glu Ala Asp Leu 580 585 590 Lys Leu Ile Cys Asp Gly Lys Lys Asp Lys Phe Val Val Leu Arg Gln 595 600 605 Gln Val Gln Lys Tyr Lys Gln Val Phe Ile Glu Ala Val Ala Lys Ala 610 615 620 Lys Lys Leu Asp Glu Ala Leu Ala Gln Tyr Phe Gly Asn Gly Thr Glu 625 630 635 640 Leu Ala Gln Gln Glu Asp Ile Tyr Pro Ala Met Pro Glu Pro Ile Arg 645 650 655 Lys Cys Pro Gln Cys Asn Lys Asp Met Val Leu Lys Thr Lys Lys Asn 660 665 670 Gly Gly Phe Tyr Leu Ser Cys Met Gly Phe Pro Glu Cys Arg Ser Ala 675 680 685 Val Trp Leu Pro Asp Ser Val Leu Glu Ala Ser Arg Asp Ser Ser Val 690 695 700 Cys Pro Val Cys Gln Pro His Pro Val Tyr Arg Leu Lys Leu Lys Phe 705 710 715 720 Lys Arg Gly Ser Leu Pro Pro Thr Met Pro Leu Glu Phe Val Cys Cys 725 730 735 Ile Gly Gly Cys Asp Asp Thr Leu Arg Glu Ile Leu Asp Leu Arg Phe 740 745 750 Ser Gly Gly Pro Pro Arg Ala Ser Gln Pro Ser Gly Arg Leu Gln Ala 755 760 765 Asn Gln Ser Leu Asn Arg Met Asp Asn Ser Gln His Pro Gln Pro Ala 770 775 780 Asp Ser Arg Gln Thr Gly Ser Ser Lys Ala Leu Ala Gln Thr Leu Pro 785 790 795 800 Pro Pro Thr Ala Ala Gly Glu Ser Asn Ser Val Thr Cys Asn Cys Gly 805 810 815 Gln Glu Ala Val Leu Leu Thr Val Arg Lys Glu Gly Pro Asn Arg Gly 820 825 830 Arg Gln Phe Phe Lys Cys Asn Gly Gly Ser Cys Asn Phe Phe Leu Trp 835 840 845 Ala Asp Ser Pro Asn Pro Gly Ala Gly Gly Pro Pro Ala Leu Ala Tyr 850 855 860 Arg Pro Leu Gly Ala Ser Leu Gly Cys Pro Pro Gly Pro Gly Ile His 865 870 875 880 Leu Gly Gly Phe Gly Asn Pro Gly Asp Gly Ser Gly Ser Gly Thr Ser 885 890 895 Cys Leu Cys Ser Gln Pro Ser Val Thr Arg Thr Val Gln Lys Asp Gly 900 905 910 Pro Asn Lys Gly Arg Gln Phe His Thr Cys Ala Lys Pro Arg Glu Gln 915 920 925 Gln Cys Gly Phe Phe Gln Trp Val Asp Glu Asn Thr Ala Pro Gly Thr 930 935 940 Ser Gly Ala Pro Ser Trp Thr Gly Asp Arg Gly Arg Thr Leu Glu Ser 945 950 955 960 Glu Ala Arg Ser Lys Arg Pro Arg Ala Ser Ser Ser Asp Met Gly Ser 965 970 975 Thr Ala Lys Lys Pro Arg Lys Cys Ser Leu Cys His Gln Pro Gly His 980 985 990 Thr Arg Pro Phe Cys Pro Gln Asn Arg 995 1000 <210> 916 <211> 1001 <212> PRT <213> Homo sapiens <400> 916 Met Ile Phe Pro Val Ala Arg Tyr Ala Leu Arg Trp Leu Arg Arg Pro 1 5 10 15 Glu Asp Arg Ala Phe Ser Arg Ala Ala Met Glu Met Ala Leu Arg Gly 20 25 30 Val Arg Lys Val Leu Cys Val Ala Glu Lys Asn Asp Ala Ala Lys Gly 35 40 45 Ile Ala Asp Leu Leu Ser Asn Gly Arg Met Arg Arg Arg Glu Gly Leu 50 55 60 Ser Lys Phe Asn Lys Ile Tyr Glu Phe Asp Tyr His Leu Tyr Gly Gln 65 70 75 80 Asn Val Thr Met Val Met Thr Ser Val Ser Gly His Leu Leu Ala His 85 90 95 Asp Phe Gln Met Gln Phe Arg Lys Trp Gln Ser Cys Asn Pro Leu Val 100 105 110 Leu Phe Glu Ala Glu Ile Glu Lys Tyr Cys Pro Glu Asn Phe Val Asp 115 120 125 Ile Lys Lys Thr Leu Glu Arg Glu Thr Arg Gln Cys Gln Ala Leu Val 130 135 140 Ile Trp Thr Asp Cys Asp Arg Glu Gly Glu Asn Ile Gly Phe Glu Ile 145 150 155 160 Ile His Val Cys Lys Ala Val Lys Pro Asn Leu Gln Val Leu Arg Ala 165 170 175 Arg Phe Ser Glu Ile Thr Pro His Ala Val Arg Thr Ala Cys Glu Asn 180 185 190 Leu Thr Glu Pro Asp Gln Arg Val Ser Asp Ala Val Asp Val Arg Gln 195 200 205 Glu Leu Asp Leu Arg Ile Gly Ala Ala Phe Thr Arg Phe Gln Thr Leu 210 215 220 Arg Leu Gln Arg Ile Phe Pro Glu Val Leu Ala Glu Gln Leu Ile Ser 225 230 235 240 Tyr Gly Ser Cys Gln Phe Pro Thr Leu Gly Phe Val Val Glu Arg Phe 245 250 255 Lys Ala Ile Gln Ala Phe Val Pro Glu Ile Phe His Arg Ile Lys Val 260 265 270 Thr His Asp His Lys Asp Gly Ile Val Glu Phe Asn Trp Lys Arg His 275 280 285 Arg Leu Phe Asn His Thr Ala Cys Leu Val Leu Tyr Gln Leu Cys Val 290 295 300 Glu Asp Pro Met Ala Thr Val Val Glu Val Arg Ser Lys Pro Lys Ser 305 310 315 320 Lys Trp Arg Pro Gln Ala Leu Asp Thr Val Glu Leu Glu Lys Leu Ala 325 330 335 Ser Arg Lys Leu Arg Ile Asn Ala Lys Glu Thr Met Arg Ile Ala Glu 340 345 350 Lys Leu Tyr Thr Gln Gly Tyr Ile Ser Tyr Pro Arg Thr Glu Thr Asn 355 360 365 Ile Phe Pro Arg Asp Leu Asn Leu Thr Val Leu Val Glu Gln Gln Thr 370 375 380 Pro Asp Pro Arg Trp Gly Ala Phe Ala Gln Ser Ile Leu Glu Arg Gly 385 390 395 400 Gly Pro Thr Pro Arg Asn Gly Asn Lys Ser Asp Gln Ala His Pro Pro 405 410 415 Ile His Pro Thr Lys Tyr Thr Asn Asn Leu Gln Gly Asp Glu Gln Arg 420 425 430 Leu Tyr Glu Phe Ile Val Arg His Phe Leu Ala Cys Cys Ser Gln Asp 435 440 445 Ala Gln Gly Gln Glu Thr Thr Val Glu Ile Asp Ile Ala Gln Glu Arg 450 455 460 Phe Val Ala His Gly Leu Met Ile Leu Ala Arg Asn Tyr Leu Asp Val 465 470 475 480 Tyr Pro Tyr Asp His Trp Ser Asp Lys Ile Leu Pro Val Tyr Glu Gln 485 490 495 Gly Ser His Phe Gln Pro Ser Thr Val Glu Met Val Asp Gly Glu Thr 500 505 510 Ser Pro Pro Lys Leu Leu Thr Glu Ala Asp Leu Ile Ala Leu Met Glu 515 520 525 Lys His Gly Ile Gly Thr Asp Ala Thr His Ala Glu His Ile Glu Thr 530 535 540 Ile Lys Ala Arg Met Tyr Val Gly Leu Thr Pro Asp Lys Arg Phe Leu 545 550 555 560 Pro Gly His Leu Gly Met Gly Leu Val Glu Gly Tyr Asp Ser Met Gly 565 570 575 Tyr Glu Met Ser Lys Pro Asp Leu Arg Ala Glu Leu Glu Ala Asp Leu 580 585 590 Lys Leu Ile Cys Asp Gly Lys Lys Asp Lys Phe Val Val Leu Arg Gln 595 600 605 Gln Val Gln Lys Tyr Lys Gln Val Phe Ile Glu Ala Val Ala Lys Ala 610 615 620 Lys Lys Leu Asp Glu Ala Leu Ala Gln Tyr Phe Gly Asn Gly Thr Glu 625 630 635 640 Leu Ala Gln Gln Glu Asp Ile Tyr Pro Ala Met Pro Glu Pro Ile Arg 645 650 655 Lys Cys Pro Gln Cys Asn Lys Asp Met Val Leu Lys Thr Lys Lys Asn 660 665 670 Gly Gly Phe Tyr Leu Ser Cys Met Gly Phe Pro Glu Cys Arg Ser Ala 675 680 685 Val Trp Leu Pro Asp Ser Val Leu Glu Ala Ser Arg Asp Ser Ser Val 690 695 700 Cys Pro Val Cys Gln Pro His Pro Val Tyr Arg Leu Lys Leu Lys Phe 705 710 715 720 Lys Arg Gly Ser Leu Pro Pro Thr Met Pro Leu Glu Phe Val Cys Cys 725 730 735 Ile Gly Gly Cys Asp Asp Thr Leu Arg Glu Ile Leu Asp Leu Arg Phe 740 745 750 Ser Gly Gly Pro Pro Arg Ala Ser Gln Pro Ser Gly Arg Leu Gln Ala 755 760 765 Asn Gln Ser Leu Asn Arg Met Asp Asn Ser Gln His Pro Gln Pro Ala 770 775 780 Asp Ser Arg Gln Thr Gly Ser Ser Lys Ala Leu Ala Gln Thr Leu Pro 785 790 795 800 Pro Pro Thr Ala Ala Gly Glu Ser Asn Ser Val Thr Cys Asn Cys Gly 805 810 815 Gln Glu Ala Val Leu Leu Thr Val Arg Lys Glu Gly Pro Asn Arg Gly 820 825 830 Arg Gln Phe Phe Lys Cys Asn Gly Gly Ser Cys Asn Phe Phe Leu Trp 835 840 845 Ala Asp Ser Pro Asn Pro Gly Ala Gly Gly Pro Pro Ala Leu Ala Tyr 850 855 860 Arg Pro Leu Gly Ala Ser Leu Gly Cys Pro Pro Gly Pro Gly Ile His 865 870 875 880 Leu Gly Gly Phe Gly Asn Pro Gly Asp Gly Ser Gly Ser Gly Thr Ser 885 890 895 Cys Leu Cys Ser Gln Pro Ser Val Thr Arg Thr Val Gln Lys Asp Gly 900 905 910 Pro Asn Lys Gly Arg Gln Phe His Thr Cys Ala Lys Pro Arg Glu Gln 915 920 925 Gln Cys Gly Phe Phe Gln Trp Val Asp Glu Asn Thr Ala Pro Gly Thr 930 935 940 Ser Gly Ala Pro Ser Trp Thr Gly Asp Arg Gly Arg Thr Leu Glu Ser 945 950 955 960 Glu Ala Arg Ser Lys Arg Pro Arg Ala Ser Ser Ser Asp Met Gly Ser 965 970 975 Thr Ala Lys Lys Pro Arg Lys Cys Ser Leu Cys His Gln Pro Gly His 980 985 990 Thr Arg Pro Phe Cys Pro Gln Asn Arg 995 1000 <210> 917 <211> 1001 <212> PRT <213> Homo sapiens <400> 917 Met Ile Phe Pro Val Ala Arg Tyr Ala Leu Arg Trp Leu Arg Arg Pro 1 5 10 15 Glu Asp Arg Ala Phe Ser Arg Ala Ala Met Glu Met Ala Leu Arg Gly 20 25 30 Val Arg Lys Val Leu Cys Val Ala Glu Lys Asn Asp Ala Ala Lys Gly 35 40 45 Ile Ala Asp Leu Leu Ser Asn Gly Arg Met Arg Arg Arg Glu Gly Leu 50 55 60 Ser Lys Phe Asn Lys Ile Tyr Glu Phe Asp Tyr His Leu Tyr Gly Gln 65 70 75 80 Asn Val Thr Met Val Met Thr Ser Val Ser Gly His Leu Leu Ala His 85 90 95 Asp Phe Gln Met Gln Phe Arg Lys Trp Gln Ser Cys Asn Pro Leu Val 100 105 110 Leu Phe Glu Ala Glu Ile Glu Lys Tyr Cys Pro Glu Asn Phe Val Asp 115 120 125 Ile Lys Lys Thr Leu Glu Arg Glu Thr Arg Gln Cys Gln Ala Leu Val 130 135 140 Ile Trp Thr Asp Cys Asp Arg Glu Gly Glu Asn Ile Gly Phe Glu Ile 145 150 155 160 Ile His Val Cys Lys Ala Val Lys Pro Asn Leu Gln Val Leu Arg Ala 165 170 175 Arg Phe Ser Glu Ile Thr Pro His Ala Val Arg Thr Ala Cys Glu Asn 180 185 190 Leu Thr Glu Pro Asp Gln Arg Val Ser Asp Ala Val Asp Val Arg Gln 195 200 205 Glu Leu Asp Leu Arg Ile Gly Ala Ala Phe Thr Arg Phe Gln Thr Leu 210 215 220 Arg Leu Gln Arg Ile Phe Pro Glu Val Leu Ala Glu Gln Leu Ile Ser 225 230 235 240 Tyr Gly Ser Cys Gln Phe Pro Thr Leu Gly Phe Val Val Glu Arg Phe 245 250 255 Lys Ala Ile Gln Ala Phe Val Pro Glu Ile Phe His Arg Ile Lys Val 260 265 270 Thr His Asp His Lys Asp Gly Ile Val Glu Phe Asn Trp Lys Arg His 275 280 285 Arg Leu Phe Asn His Thr Ala Cys Leu Val Leu Tyr Gln Leu Cys Val 290 295 300 Glu Asp Pro Met Ala Thr Val Val Glu Val Arg Ser Lys Pro Lys Ser 305 310 315 320 Lys Trp Arg Pro Gln Ala Leu Asp Thr Val Glu Leu Glu Lys Leu Ala 325 330 335 Ser Arg Lys Leu Arg Ile Asn Ala Lys Glu Thr Met Arg Ile Ala Glu 340 345 350 Lys Leu Tyr Thr Gln Gly Tyr Ile Ser Tyr Pro Arg Thr Glu Thr Asn 355 360 365 Ile Phe Pro Arg Asp Leu Asn Leu Thr Val Leu Val Glu Gln Gln Thr 370 375 380 Pro Asp Pro Arg Trp Gly Ala Phe Ala Gln Ser Ile Leu Glu Arg Gly 385 390 395 400 Gly Pro Thr Pro Arg Asn Gly Asn Lys Ser Asp Gln Ala His Pro Pro 405 410 415 Ile His Pro Thr Lys Tyr Thr Asn Asn Leu Gln Gly Asp Glu Gln Arg 420 425 430 Leu Tyr Glu Phe Ile Val Arg His Phe Leu Ala Cys Cys Ser Gln Asp 435 440 445 Ala Gln Gly Gln Glu Thr Thr Val Glu Ile Asp Ile Ala Gln Glu Arg 450 455 460 Phe Val Ala His Gly Leu Met Ile Leu Ala Arg Asn Tyr Leu Asp Val 465 470 475 480 Tyr Pro Tyr Asp His Trp Ser Asp Lys Ile Leu Pro Val Tyr Glu Gln 485 490 495 Gly Ser His Phe Gln Pro Ser Thr Val Glu Met Val Asp Gly Glu Thr 500 505 510 Ser Pro Pro Lys Leu Leu Thr Glu Ala Asp Leu Ile Ala Leu Met Glu 515 520 525 Lys His Gly Ile Gly Thr Asp Ala Thr His Ala Glu His Ile Glu Thr 530 535 540 Ile Lys Ala Arg Met Tyr Val Gly Leu Thr Pro Asp Lys Arg Phe Leu 545 550 555 560 Pro Gly His Leu Gly Met Gly Leu Val Glu Gly Tyr Asp Ser Met Gly 565 570 575 Tyr Glu Met Ser Lys Pro Asp Leu Arg Ala Glu Leu Glu Ala Asp Leu 580 585 590 Lys Leu Ile Cys Asp Gly Lys Lys Asp Lys Phe Val Val Leu Arg Gln 595 600 605 Gln Val Gln Lys Tyr Lys Gln Val Phe Ile Glu Ala Val Ala Lys Ala 610 615 620 Lys Lys Leu Asp Glu Ala Leu Ala Gln Tyr Phe Gly Asn Gly Thr Glu 625 630 635 640 Leu Ala Gln Gln Glu Asp Ile Tyr Pro Ala Met Pro Glu Pro Ile Arg 645 650 655 Lys Cys Pro Gln Cys Asn Lys Asp Met Val Leu Lys Thr Lys Lys Asn 660 665 670 Gly Gly Phe Tyr Leu Ser Cys Met Gly Phe Pro Glu Cys Arg Ser Ala 675 680 685 Val Trp Leu Pro Asp Ser Val Leu Glu Ala Ser Arg Asp Ser Ser Val 690 695 700 Cys Pro Val Cys Gln Pro His Pro Val Tyr Arg Leu Lys Leu Lys Phe 705 710 715 720 Lys Arg Gly Ser Leu Pro Pro Thr Met Pro Leu Glu Phe Val Cys Cys 725 730 735 Ile Gly Gly Cys Asp Asp Thr Leu Arg Glu Ile Leu Asp Leu Arg Phe 740 745 750 Ser Gly Gly Pro Pro Arg Ala Ser Gln Pro Ser Gly Arg Leu Gln Ala 755 760 765 Asn Gln Ser Leu Asn Arg Met Asp Asn Ser Gln His Pro Gln Pro Ala 770 775 780 Asp Ser Arg Gln Thr Gly Ser Ser Lys Ala Leu Ala Gln Thr Leu Pro 785 790 795 800 Pro Pro Thr Ala Ala Gly Glu Ser Asn Ser Val Thr Cys Asn Cys Gly 805 810 815 Gln Glu Ala Val Leu Leu Thr Val Arg Lys Glu Gly Pro Asn Arg Gly 820 825 830 Arg Gln Phe Phe Lys Cys Asn Gly Gly Ser Cys Asn Phe Phe Leu Trp 835 840 845 Ala Asp Ser Pro Asn Pro Gly Ala Gly Gly Pro Pro Ala Leu Ala Tyr 850 855 860 Arg Pro Leu Gly Ala Ser Leu Gly Cys Pro Pro Gly Pro Gly Ile His 865 870 875 880 Leu Gly Gly Phe Gly Asn Pro Gly Asp Gly Ser Gly Ser Gly Thr Ser 885 890 895 Cys Leu Cys Ser Gln Pro Ser Val Thr Arg Thr Val Gln Lys Asp Gly 900 905 910 Pro Asn Lys Gly Arg Gln Phe His Thr Cys Ala Lys Pro Arg Glu Gln 915 920 925 Gln Cys Gly Phe Phe Gln Trp Val Asp Glu Asn Thr Ala Pro Gly Thr 930 935 940 Ser Gly Ala Pro Ser Trp Thr Gly Asp Arg Gly Arg Thr Leu Glu Ser 945 950 955 960 Glu Ala Arg Ser Lys Arg Pro Arg Ala Ser Ser Ser Asp Met Gly Ser 965 970 975 Thr Ala Lys Lys Pro Arg Lys Cys Ser Leu Cys His Gln Pro Gly His 980 985 990 Thr Arg Pro Phe Cys Pro Gln Asn Arg 995 1000 <210> 918 <211> 551 <212> PRT <213> Homo sapiens <400> 918 Met Ala Ala Pro Val Arg Leu Gly Arg Lys Arg Pro Leu Pro Ala Cys 1 5 10 15 Pro Asn Pro Leu Phe Val Arg Trp Leu Thr Glu Trp Arg Asp Glu Ala 20 25 30 Thr Arg Ser Arg His Arg Thr Arg Phe Val Phe Gln Lys Ala Leu Arg 35 40 45 Ser Leu Arg Arg Tyr Pro Leu Pro Leu Arg Ser Gly Lys Glu Ala Lys 50 55 60 Ile Leu Gln His Phe Gly Asp Gly Leu Cys Arg Met Leu Asp Glu Arg 65 70 75 80 Leu Gln Arg His Arg Thr Ser Gly Gly Asp His Ala Pro Asp Ser Pro 85 90 95 Ser Gly Glu Asn Ser Pro Ala Pro Gln Gly Arg Leu Ala Glu Val Gln 100 105 110 Asp Ser Ser Met Pro Val Pro Ala Gln Pro Lys Ala Gly Gly Ser Gly 115 120 125 Ser Tyr Trp Pro Ala Arg His Ser Gly Ala Arg Val Ile Leu Leu Val 130 135 140 Leu Tyr Arg Glu His Leu Asn Pro Asn Gly His His Phe Leu Thr Lys 145 150 155 160 Glu Glu Leu Leu Gln Arg Cys Ala Gln Lys Ser Pro Arg Val Ala Pro 165 170 175 Gly Ser Ala Pro Pro Trp Pro Ala Leu Arg Ser Leu Leu His Arg Asn 180 185 190 Leu Val Leu Arg Thr His Gln Pro Ala Arg Tyr Ser Leu Thr Pro Glu 195 200 205 Gly Leu Glu Leu Ala Gln Lys Leu Ala Glu Ser Glu Gly Leu Ser Leu 210 215 220 Leu Asn Val Gly Ile Gly Pro Lys Glu Pro Pro Gly Glu Glu Thr Ala 225 230 235 240 Val Pro Gly Ala Ala Ser Ala Glu Leu Ala Ser Glu Ala Gly Val Gln 245 250 255 Gln Gln Pro Leu Glu Leu Arg Pro Gly Glu Tyr Arg Val Leu Leu Cys 260 265 270 Val Asp Ile Gly Glu Thr Arg Gly Gly Gly His Arg Pro Glu Leu Leu 275 280 285 Arg Glu Leu Gln Arg Leu His Val Thr His Thr Val Arg Lys Leu His 290 295 300 Val Gly Asp Phe Val Trp Val Ala Gln Glu Thr Asn Pro Arg Asp Pro 305 310 315 320 Ala Asn Pro Gly Glu Leu Val Leu Asp His Ile Val Glu Arg Lys Arg 325 330 335 Leu Asp Asp Leu Cys Ser Ser Ile Ile Asp Gly Arg Phe Arg Glu Gln 340 345 350 Lys Phe Arg Leu Lys Arg Cys Gly Leu Glu Arg Arg Val Tyr Leu Val 355 360 365 Glu Glu His Gly Ser Val His Asn Leu Ser Leu Pro Glu Ser Thr Leu 370 375 380 Leu Gln Ala Val Thr Asn Thr Gln Val Ile Asp Gly Phe Phe Val Lys 385 390 395 400 Arg Thr Ala Asp Ile Lys Glu Ser Ala Ala Tyr Leu Ala Leu Leu Thr 405 410 415 Arg Gly Leu Gln Arg Leu Tyr Gln Gly His Thr Leu Arg Ser Arg Pro 420 425 430 Trp Gly Thr Pro Gly Asn Pro Glu Ser Gly Ala Met Thr Ser Pro Asn 435 440 445 Pro Leu Cys Ser Leu Leu Thr Phe Ser Asp Phe Asn Ala Gly Ala Ile 450 455 460 Lys Asn Lys Ala Gln Ser Val Arg Glu Val Phe Ala Arg Gln Leu Met 465 470 475 480 Gln Val Arg Gly Val Ser Gly Glu Lys Ala Ala Ala Leu Val Asp Arg 485 490 495 Tyr Ser Thr Pro Ala Ser Leu Leu Ala Ala Tyr Asp Ala Cys Ala Thr 500 505 510 Pro Lys Glu Gln Glu Thr Leu Leu Ser Thr Ile Lys Cys Gly Arg Leu 515 520 525 Gln Arg Asn Leu Gly Pro Ala Leu Ser Arg Thr Leu Ser Gln Leu Tyr 530 535 540 Cys Ser Tyr Gly Pro Leu Thr 545 550 <210> 919 <211> 236 <212> PRT <213> Homo sapiens <400> 919 Pro Glu Gly Leu Glu Leu Ala Gln Lys Leu Ala Glu Ser Glu Gly Leu 1 5 10 15 Ser Leu Leu Asn Val Gly Ile Gly Pro Lys Glu Pro Pro Gly Glu Glu 20 25 30 Thr Ala Val Pro Gly Ala Ala Ser Ala Glu Leu Ala Ser Glu Ala Gly 35 40 45 Val Gln Gln Gln Pro Leu Glu Leu Arg Pro Gly Glu Tyr Arg Val Leu 50 55 60 Leu Cys Val Asp Ile Gly Glu Thr Arg Gly Gly Gly His Arg Pro Glu 65 70 75 80 Leu Leu Arg Glu Leu Gln Arg Leu His Val Thr His Thr Val Arg Lys 85 90 95 Leu His Val Gly Asp Phe Val Trp Val Ala Gln Glu Thr Asn Pro Arg 100 105 110 Asp Pro Ala Asn Pro Gly Glu Leu Val Leu Asp His Ile Val Glu Arg 115 120 125 Lys Arg Leu Asp Asp Leu Cys Ser Ser Ile Ile Asp Gly Arg Phe Arg 130 135 140 Glu Gln Lys Val Ile Leu Leu Ala Leu Pro Gly Phe Pro Ala Cys Ser 145 150 155 160 Glu Ala Pro Phe Ser Ala Gln Ser Asn Pro Gly Ala Leu Leu Ala Ala 165 170 175 Ser Leu Arg Gln Ser Pro Leu Glu Ser Ser His Thr His Pro Val Ala 180 185 190 Ala Pro Gly Ser Asp Pro His Arg Pro Ile Gln Ala His Ser Arg Lys 195 200 205 Pro Val Pro Ala Glu Ala Leu Trp Ser Gly Ala Pro Gly Ile Pro Gly 210 215 220 Gly Arg Ala Trp Phe Arg Pro Gln Pro Gln Pro Ser 225 230 235 <210> 920 <211> 476 <212> PRT <213> Homo sapiens <400> 920 Met Leu Asp Glu Arg Leu Gln Arg His Arg Thr Ser Gly Gly Asp His 1 5 10 15 Ala Pro Asp Ser Pro Ser Gly Glu Asn Ser Pro Ala Pro Gln Gly Arg 20 25 30 Leu Ala Glu Val Gln Asp Ser Ser Met Pro Val Pro Ala Gln Pro Lys 35 40 45 Ala Gly Gly Ser Gly Ser Tyr Trp Pro Ala Arg His Ser Gly Ala Arg 50 55 60 Val Ile Leu Leu Val Leu Tyr Arg Glu His Leu Asn Pro Asn Gly His 65 70 75 80 His Phe Leu Thr Lys Glu Glu Leu Leu Gln Arg Cys Ala Gln Lys Ser 85 90 95 Pro Arg Val Ala Pro Gly Ser Ala Pro Pro Trp Pro Ala Leu Arg Ser 100 105 110 Leu Leu His Arg Asn Leu Val Leu Arg Thr His Gln Pro Ala Arg Tyr 115 120 125 Ser Leu Thr Pro Glu Gly Leu Glu Leu Ala Gln Lys Leu Ala Glu Ser 130 135 140 Glu Gly Leu Ser Leu Leu Asn Val Gly Ile Gly Pro Lys Glu Pro Pro 145 150 155 160 Gly Glu Glu Thr Ala Val Pro Gly Ala Ala Ser Ala Glu Leu Ala Ser 165 170 175 Glu Ala Gly Val Gln Gln Gln Pro Leu Glu Leu Arg Pro Gly Glu Tyr 180 185 190 Arg Val Leu Leu Cys Val Asp Ile Gly Glu Thr Arg Gly Gly Gly His 195 200 205 Arg Pro Glu Leu Leu Arg Glu Leu Gln Arg Leu His Val Thr His Thr 210 215 220 Val Arg Lys Leu His Val Gly Asp Phe Val Trp Val Ala Gln Glu Thr 225 230 235 240 Asn Pro Arg Asp Pro Ala Asn Pro Gly Glu Leu Val Leu Asp His Ile 245 250 255 Val Glu Arg Lys Arg Leu Asp Asp Leu Cys Ser Ser Ile Ile Asp Gly 260 265 270 Arg Phe Arg Glu Gln Lys Phe Arg Leu Lys Arg Cys Gly Leu Glu Arg 275 280 285 Arg Val Tyr Leu Val Glu Glu His Gly Ser Val His Asn Leu Ser Leu 290 295 300 Pro Glu Ser Thr Leu Leu Gln Ala Val Thr Asn Thr Gln Val Ile Asp 305 310 315 320 Gly Phe Phe Val Lys Arg Thr Ala Asp Ile Lys Glu Ser Ala Ala Tyr 325 330 335 Leu Ala Leu Leu Thr Arg Gly Leu Gln Arg Leu Tyr Gln Gly His Thr 340 345 350 Leu Arg Ser Arg Pro Trp Gly Thr Pro Gly Asn Pro Glu Ser Gly Ala 355 360 365 Met Thr Ser Pro Asn Pro Leu Cys Ser Leu Leu Thr Phe Ser Asp Phe 370 375 380 Asn Ala Gly Ala Ile Lys Asn Lys Ala Gln Ser Val Arg Glu Val Phe 385 390 395 400 Ala Arg Gln Leu Met Gln Val Arg Gly Val Ser Gly Glu Lys Ala Ala 405 410 415 Ala Leu Val Asp Arg Tyr Ser Thr Pro Ala Ser Leu Leu Ala Ala Tyr 420 425 430 Asp Ala Cys Ala Thr Pro Lys Glu Gln Glu Thr Leu Leu Ser Thr Ile 435 440 445 Lys Cys Gly Arg Leu Gln Arg Asn Leu Gly Pro Ala Leu Ser Arg Thr 450 455 460 Leu Ser Gln Leu Tyr Cys Ser Tyr Gly Pro Leu Thr 465 470 475 <210> 921 <211> 551 <212> PRT <213> Homo sapiens <400> 921 Met Ala Ala Pro Val Arg Leu Gly Arg Lys Arg Pro Leu Pro Ala Cys 1 5 10 15 Pro Asn Pro Leu Phe Val Arg Trp Leu Thr Glu Trp Arg Asp Glu Ala 20 25 30 Thr Arg Ser Arg His Arg Thr Arg Phe Val Phe Gln Lys Ala Leu Arg 35 40 45 Ser Leu Arg Arg Tyr Pro Leu Pro Leu Arg Ser Gly Lys Glu Ala Lys 50 55 60 Ile Leu Gln His Phe Gly Asp Gly Leu Cys Arg Met Leu Asp Glu Arg 65 70 75 80 Leu Gln Arg His Arg Thr Ser Gly Gly Asp His Ala Pro Asp Ser Pro 85 90 95 Ser Gly Glu Asn Ser Pro Ala Pro Gln Gly Arg Leu Ala Glu Val Gln 100 105 110 Asp Ser Ser Met Pro Val Pro Ala Gln Pro Lys Ala Gly Gly Ser Gly 115 120 125 Ser Tyr Trp Pro Ala Arg His Ser Gly Ala Arg Val Ile Leu Leu Val 130 135 140 Leu Tyr Arg Glu His Leu Asn Pro Asn Gly His His Phe Leu Thr Lys 145 150 155 160 Glu Glu Leu Leu Gln Arg Cys Ala Gln Lys Ser Pro Arg Val Ala Pro 165 170 175 Gly Ser Ala Pro Pro Trp Pro Ala Leu Arg Ser Leu Leu His Arg Asn 180 185 190 Leu Val Leu Arg Thr His Gln Pro Ala Arg Tyr Ser Leu Thr Pro Glu 195 200 205 Gly Leu Glu Leu Ala Gln Lys Leu Ala Glu Ser Glu Gly Leu Ser Leu 210 215 220 Leu Asn Val Gly Ile Gly Pro Lys Glu Pro Pro Gly Glu Glu Thr Ala 225 230 235 240 Val Pro Gly Ala Ala Ser Ala Glu Leu Ala Ser Glu Ala Gly Val Gln 245 250 255 Gln Gln Pro Leu Glu Leu Arg Pro Gly Glu Tyr Arg Val Leu Leu Cys 260 265 270 Val Asp Ile Gly Glu Thr Arg Gly Gly Gly His Arg Pro Glu Leu Leu 275 280 285 Arg Glu Leu Gln Arg Leu His Val Thr His Thr Val Arg Lys Leu His 290 295 300 Val Gly Asp Phe Val Trp Val Ala Gln Glu Thr Asn Pro Arg Asp Pro 305 310 315 320 Ala Asn Pro Gly Glu Leu Val Leu Asp His Ile Val Glu Arg Lys Arg 325 330 335 Leu Asp Asp Leu Cys Ser Ser Ile Ile Asp Gly Arg Phe Arg Glu Gln 340 345 350 Lys Phe Arg Leu Lys Arg Cys Gly Leu Glu Arg Arg Val Tyr Leu Val 355 360 365 Glu Glu His Gly Ser Val His Asn Leu Ser Leu Pro Glu Ser Thr Leu 370 375 380 Leu Gln Ala Val Thr Asn Thr Gln Val Ile Asp Gly Phe Phe Val Lys 385 390 395 400 Arg Thr Ala Asp Ile Lys Glu Ser Ala Ala Tyr Leu Ala Leu Leu Thr 405 410 415 Arg Gly Leu Gln Arg Leu Tyr Gln Gly His Thr Leu Arg Ser Arg Pro 420 425 430 Trp Gly Thr Pro Gly Asn Pro Glu Ser Gly Ala Met Thr Ser Pro Asn 435 440 445 Pro Leu Cys Ser Leu Leu Thr Phe Ser Asp Phe Asn Ala Gly Ala Ile 450 455 460 Lys Asn Lys Ala Gln Ser Val Arg Glu Val Phe Ala Arg Gln Leu Met 465 470 475 480 Gln Val Arg Gly Val Ser Gly Glu Lys Ala Ala Ala Leu Val Asp Arg 485 490 495 Tyr Ser Thr Pro Ala Ser Leu Leu Ala Ala Tyr Asp Ala Cys Ala Thr 500 505 510 Pro Lys Glu Gln Glu Thr Leu Leu Ser Thr Ile Lys Cys Gly Arg Leu 515 520 525 Gln Arg Asn Leu Gly Pro Ala Leu Ser Arg Thr Leu Ser Gln Leu Tyr 530 535 540 Cys Ser Tyr Gly Pro Leu Thr 545 550 <210> 922 <211> 551 <212> PRT <213> Homo sapiens <400> 922 Met Ala Ala Pro Val Arg Leu Gly Arg Lys Arg Pro Leu Pro Ala Cys 1 5 10 15 Pro Asn Pro Leu Phe Val Arg Trp Leu Thr Glu Trp Arg Asp Glu Ala 20 25 30 Thr Arg Ser Arg His Arg Thr Arg Phe Val Phe Gln Lys Ala Leu Arg 35 40 45 Ser Leu Arg Arg Tyr Pro Leu Pro Leu Arg Ser Gly Lys Glu Ala Lys 50 55 60 Ile Leu Gln His Phe Gly Asp Gly Leu Cys Arg Met Leu Asp Glu Arg 65 70 75 80 Leu Gln Arg His Arg Thr Ser Gly Gly Asp His Ala Pro Asp Ser Pro 85 90 95 Ser Gly Glu Asn Ser Pro Ala Pro Gln Gly Arg Leu Ala Glu Val Gln 100 105 110 Asp Ser Ser Met Pro Val Pro Ala Gln Pro Lys Ala Gly Gly Ser Gly 115 120 125 Ser Tyr Trp Pro Ala Arg His Ser Gly Ala Arg Val Ile Leu Leu Val 130 135 140 Leu Tyr Arg Glu His Leu Asn Pro Asn Gly His His Phe Leu Thr Lys 145 150 155 160 Glu Glu Leu Leu Gln Arg Cys Ala Gln Lys Ser Pro Arg Val Ala Pro 165 170 175 Gly Ser Ala Pro Pro Trp Pro Ala Leu Arg Ser Leu Leu His Arg Asn 180 185 190 Leu Val Leu Arg Thr His Gln Pro Ala Arg Tyr Ser Leu Thr Pro Glu 195 200 205 Gly Leu Glu Leu Ala Gln Lys Leu Ala Glu Ser Glu Gly Leu Ser Leu 210 215 220 Leu Asn Val Gly Ile Gly Pro Lys Glu Pro Pro Gly Glu Glu Thr Ala 225 230 235 240 Val Pro Gly Ala Ala Ser Ala Glu Leu Ala Ser Glu Ala Gly Val Gln 245 250 255 Gln Gln Pro Leu Glu Leu Arg Pro Gly Glu Tyr Arg Val Leu Leu Cys 260 265 270 Val Asp Ile Gly Glu Thr Arg Gly Gly Gly His Arg Pro Glu Leu Leu 275 280 285 Arg Glu Leu Gln Arg Leu His Val Thr His Thr Val Arg Lys Leu His 290 295 300 Val Gly Asp Phe Val Trp Val Ala Gln Glu Thr Asn Pro Arg Asp Pro 305 310 315 320 Ala Asn Pro Gly Glu Leu Val Leu Asp His Ile Val Glu Arg Lys Arg 325 330 335 Leu Asp Asp Leu Cys Ser Ser Ile Ile Asp Gly Arg Phe Arg Glu Gln 340 345 350 Lys Phe Arg Leu Lys Arg Cys Gly Leu Glu Arg Arg Val Tyr Leu Val 355 360 365 Glu Glu His Gly Ser Val His Asn Leu Ser Leu Pro Glu Ser Thr Leu 370 375 380 Leu Gln Ala Val Thr Asn Thr Gln Val Ile Asp Gly Phe Phe Val Lys 385 390 395 400 Arg Thr Ala Asp Ile Lys Glu Ser Ala Ala Tyr Leu Ala Leu Leu Thr 405 410 415 Arg Gly Leu Gln Arg Leu Tyr Gln Gly His Thr Leu Arg Ser Arg Pro 420 425 430 Trp Gly Thr Pro Gly Asn Pro Glu Ser Gly Ala Met Thr Ser Pro Asn 435 440 445 Pro Leu Cys Ser Leu Leu Thr Phe Ser Asp Phe Asn Ala Gly Ala Ile 450 455 460 Lys Asn Lys Ala Gln Ser Val Arg Glu Val Phe Ala Arg Gln Leu Met 465 470 475 480 Gln Val Arg Gly Val Ser Gly Glu Lys Ala Ala Ala Leu Val Asp Arg 485 490 495 Tyr Ser Thr Pro Ala Ser Leu Leu Ala Ala Tyr Asp Ala Cys Ala Thr 500 505 510 Pro Lys Glu Gln Glu Thr Leu Leu Ser Thr Ile Lys Cys Gly Arg Leu 515 520 525 Gln Arg Asn Leu Gly Pro Ala Leu Ser Arg Thr Leu Ser Gln Leu Tyr 530 535 540 Cys Ser Tyr Gly Pro Leu Thr 545 550 <210> 923 <211> 551 <212> PRT <213> Homo sapiens <400> 923 Met Ala Ala Pro Val Arg Leu Gly Arg Lys Arg Pro Leu Pro Ala Cys 1 5 10 15 Pro Asn Pro Leu Phe Val Arg Trp Leu Thr Glu Trp Arg Asp Glu Ala 20 25 30 Thr Arg Ser Arg His Arg Thr Arg Phe Val Phe Gln Lys Ala Leu Arg 35 40 45 Ser Leu Arg Arg Tyr Pro Leu Pro Leu Arg Ser Gly Lys Glu Ala Lys 50 55 60 Ile Leu Gln His Phe Gly Asp Gly Leu Cys Arg Met Leu Asp Glu Arg 65 70 75 80 Leu Gln Arg His Arg Thr Ser Gly Gly Asp His Ala Pro Asp Ser Pro 85 90 95 Ser Gly Glu Asn Ser Pro Ala Pro Gln Gly Arg Leu Ala Glu Val Gln 100 105 110 Asp Ser Ser Met Pro Val Pro Ala Gln Pro Lys Ala Gly Gly Ser Gly 115 120 125 Ser Tyr Trp Pro Ala Arg His Ser Gly Ala Arg Val Ile Leu Leu Val 130 135 140 Leu Tyr Arg Glu His Leu Asn Pro Asn Gly His His Phe Leu Thr Lys 145 150 155 160 Glu Glu Leu Leu Gln Arg Cys Ala Gln Lys Ser Pro Arg Val Ala Pro 165 170 175 Gly Ser Ala Pro Pro Trp Pro Ala Leu Arg Ser Leu Leu His Arg Asn 180 185 190 Leu Val Leu Arg Thr His Gln Pro Ala Arg Tyr Ser Leu Thr Pro Glu 195 200 205 Gly Leu Glu Leu Ala Gln Lys Leu Ala Glu Ser Glu Gly Leu Ser Leu 210 215 220 Leu Asn Val Gly Ile Gly Pro Lys Glu Pro Pro Gly Glu Glu Thr Ala 225 230 235 240 Val Pro Gly Ala Ala Ser Ala Glu Leu Ala Ser Glu Ala Gly Val Gln 245 250 255 Gln Gln Pro Leu Glu Leu Arg Pro Gly Glu Tyr Arg Val Leu Leu Cys 260 265 270 Val Asp Ile Gly Glu Thr Arg Gly Gly Gly His Arg Pro Glu Leu Leu 275 280 285 Arg Glu Leu Gln Arg Leu His Val Thr His Thr Val Arg Lys Leu His 290 295 300 Val Gly Asp Phe Val Trp Val Ala Gln Glu Thr Asn Pro Arg Asp Pro 305 310 315 320 Ala Asn Pro Gly Glu Leu Val Leu Asp His Ile Val Glu Arg Lys Arg 325 330 335 Leu Asp Asp Leu Cys Ser Ser Ile Ile Asp Gly Arg Phe Arg Glu Gln 340 345 350 Lys Phe Arg Leu Lys Arg Cys Gly Leu Glu Arg Arg Val Tyr Leu Val 355 360 365 Glu Glu His Gly Ser Val His Asn Leu Ser Leu Pro Glu Ser Thr Leu 370 375 380 Leu Gln Ala Val Thr Asn Thr Gln Val Ile Asp Gly Phe Phe Val Lys 385 390 395 400 Arg Thr Ala Asp Ile Lys Glu Ser Ala Ala Tyr Leu Ala Leu Leu Thr 405 410 415 Arg Gly Leu Gln Arg Leu Tyr Gln Gly His Thr Leu Arg Ser Arg Pro 420 425 430 Trp Gly Thr Pro Gly Asn Pro Glu Ser Gly Ala Met Thr Ser Pro Asn 435 440 445 Pro Leu Cys Ser Leu Leu Thr Phe Ser Asp Phe Asn Ala Gly Ala Ile 450 455 460 Lys Asn Lys Ala Gln Ser Val Arg Glu Val Phe Ala Arg Gln Leu Met 465 470 475 480 Gln Val Arg Gly Val Ser Gly Glu Lys Ala Ala Ala Leu Val Asp Arg 485 490 495 Tyr Ser Thr Pro Ala Ser Leu Leu Ala Ala Tyr Asp Ala Cys Ala Thr 500 505 510 Pro Lys Glu Gln Glu Thr Leu Leu Ser Thr Ile Lys Cys Gly Arg Leu 515 520 525 Gln Arg Asn Leu Gly Pro Ala Leu Ser Arg Thr Leu Ser Gln Leu Tyr 530 535 540 Cys Ser Tyr Gly Pro Leu Thr 545 550 <210> 924 <211> 747 <212> PRT <213> Homo sapiens <400> 924 Met Ala Asp Glu Ala Ala Leu Ala Leu Gln Pro Gly Gly Ser Pro Ser 1 5 10 15 Ala Ala Gly Ala Asp Arg Glu Ala Ala Ser Ser Pro Ala Gly Glu Pro 20 25 30 Leu Arg Lys Arg Pro Arg Arg Asp Gly Pro Gly Leu Glu Arg Ser Pro 35 40 45 Gly Glu Pro Gly Gly Ala Ala Pro Glu Arg Glu Val Pro Ala Ala Ala 50 55 60 Arg Gly Cys Pro Gly Ala Ala Ala Ala Ala Leu Trp Arg Glu Ala Glu 65 70 75 80 Ala Glu Ala Ala Ala Ala Gly Gly Glu Gln Glu Ala Gln Ala Thr Ala 85 90 95 Ala Ala Gly Glu Gly Asp Asn Gly Pro Gly Leu Gln Gly Pro Ser Arg 100 105 110 Glu Pro Pro Leu Ala Asp Asn Leu Tyr Asp Glu Asp Asp Asp Asp Glu 115 120 125 Gly Glu Glu Glu Glu Glu Ala Ala Ala Ala Ala Ile Gly Tyr Arg Asp 130 135 140 Asn Leu Leu Phe Gly Asp Glu Ile Ile Thr Asn Gly Phe His Ser Cys 145 150 155 160 Glu Ser Asp Glu Glu Asp Arg Ala Ser His Ala Ser Ser Ser Asp Trp 165 170 175 Thr Pro Arg Pro Arg Ile Gly Pro Tyr Thr Phe Val Gln Gln His Leu 180 185 190 Met Ile Gly Thr Asp Pro Arg Thr Ile Leu Lys Asp Leu Leu Pro Glu 195 200 205 Thr Ile Pro Pro Pro Glu Leu Asp Asp Met Thr Leu Trp Gln Ile Val 210 215 220 Ile Asn Ile Leu Ser Glu Pro Pro Lys Arg Lys Lys Arg Lys Asp Ile 225 230 235 240 Asn Thr Ile Glu Asp Ala Val Lys Leu Leu Gln Glu Cys Lys Lys Ile 245 250 255 Ile Val Leu Thr Gly Ala Gly Val Ser Val Ser Cys Gly Ile Pro Asp 260 265 270 Phe Arg Ser Arg Asp Gly Ile Tyr Ala Arg Leu Ala Val Asp Phe Pro 275 280 285 Asp Leu Pro Asp Pro Gln Ala Met Phe Asp Ile Glu Tyr Phe Arg Lys 290 295 300 Asp Pro Arg Pro Phe Phe Lys Phe Ala Lys Glu Ile Tyr Pro Gly Gln 305 310 315 320 Phe Gln Pro Ser Leu Cys His Lys Phe Ile Ala Leu Ser Asp Lys Glu 325 330 335 Gly Lys Leu Leu Arg Asn Tyr Thr Gln Asn Ile Asp Thr Leu Glu Gln 340 345 350 Val Ala Gly Ile Gln Arg Ile Ile Gln Cys His Gly Ser Phe Ala Thr 355 360 365 Ala Ser Cys Leu Ile Cys Lys Tyr Lys Val Asp Cys Glu Ala Val Arg 370 375 380 Gly Asp Ile Phe Asn Gln Val Val Pro Arg Cys Pro Arg Cys Pro Ala 385 390 395 400 Asp Glu Pro Leu Ala Ile Met Lys Pro Glu Ile Val Phe Phe Gly Glu 405 410 415 Asn Leu Pro Glu Gln Phe His Arg Ala Met Lys Tyr Asp Lys Asp Glu 420 425 430 Val Asp Leu Leu Ile Val Ile Gly Ser Ser Leu Lys Val Arg Pro Val 435 440 445 Ala Leu Ile Pro Ser Ser Ile Pro His Glu Val Pro Gln Ile Leu Ile 450 455 460 Asn Arg Glu Pro Leu Pro His Leu His Phe Asp Val Glu Leu Leu Gly 465 470 475 480 Asp Cys Asp Val Ile Ile Asn Glu Leu Cys His Arg Leu Gly Gly Glu 485 490 495 Tyr Ala Lys Leu Cys Cys Asn Pro Val Lys Leu Ser Glu Ile Thr Glu 500 505 510 Lys Pro Pro Arg Thr Gln Lys Glu Leu Ala Tyr Leu Ser Glu Leu Pro 515 520 525 Pro Thr Pro Leu His Val Ser Glu Asp Ser Ser Ser Pro Glu Arg Thr 530 535 540 Ser Pro Pro Asp Ser Ser Val Ile Val Thr Leu Leu Asp Gln Ala Ala 545 550 555 560 Lys Ser Asn Asp Asp Leu Asp Val Ser Glu Ser Lys Gly Cys Met Glu 565 570 575 Glu Lys Pro Gln Glu Val Gln Thr Ser Arg Asn Val Glu Ser Ile Ala 580 585 590 Glu Gln Met Glu Asn Pro Asp Leu Lys Asn Val Gly Ser Ser Thr Gly 595 600 605 Glu Lys Asn Glu Arg Thr Ser Val Ala Gly Thr Val Arg Lys Cys Trp 610 615 620 Pro Asn Arg Val Ala Lys Glu Gln Ile Ser Arg Arg Leu Asp Gly Asn 625 630 635 640 Gln Tyr Leu Phe Leu Pro Pro Asn Arg Tyr Ile Phe His Gly Ala Glu 645 650 655 Val Tyr Ser Asp Ser Glu Asp Asp Val Leu Ser Ser Ser Ser Cys Gly 660 665 670 Ser Asn Ser Asp Ser Gly Thr Cys Gln Ser Pro Ser Leu Glu Glu Pro 675 680 685 Met Glu Asp Glu Ser Glu Ile Glu Glu Phe Tyr Asn Gly Leu Glu Asp 690 695 700 Glu Pro Asp Val Pro Glu Arg Ala Gly Gly Ala Gly Phe Gly Thr Asp 705 710 715 720 Gly Asp Asp Gln Glu Ala Ile Asn Glu Ala Ile Ser Val Lys Gln Glu 725 730 735 Val Thr Asp Met Asn Tyr Pro Ser Asn Lys Ser 740 745 <210> 925 <211> 747 <212> PRT <213> Homo sapiens <400> 925 Met Ala Asp Glu Ala Ala Leu Ala Leu Gln Pro Gly Gly Ser Pro Ser 1 5 10 15 Ala Ala Gly Ala Asp Arg Glu Ala Ala Ser Ser Pro Ala Gly Glu Pro 20 25 30 Leu Arg Lys Arg Pro Arg Arg Asp Gly Pro Gly Leu Glu Arg Ser Pro 35 40 45 Gly Glu Pro Gly Gly Ala Ala Pro Glu Arg Glu Val Pro Ala Ala Ala 50 55 60 Arg Gly Cys Pro Gly Ala Ala Ala Ala Ala Leu Trp Arg Glu Ala Glu 65 70 75 80 Ala Glu Ala Ala Ala Ala Gly Gly Glu Gln Glu Ala Gln Ala Thr Ala 85 90 95 Ala Ala Gly Glu Gly Asp Asn Gly Pro Gly Leu Gln Gly Pro Ser Arg 100 105 110 Glu Pro Pro Leu Ala Asp Asn Leu Tyr Asp Glu Asp Asp Asp Asp Glu 115 120 125 Gly Glu Glu Glu Glu Glu Ala Ala Ala Ala Ala Ile Gly Tyr Arg Asp 130 135 140 Asn Leu Leu Phe Gly Asp Glu Ile Ile Thr Asn Gly Phe His Ser Cys 145 150 155 160 Glu Ser Asp Glu Glu Asp Arg Ala Ser His Ala Ser Ser Ser Asp Trp 165 170 175 Thr Pro Arg Pro Arg Ile Gly Pro Tyr Thr Phe Val Gln Gln His Leu 180 185 190 Met Ile Gly Thr Asp Pro Arg Thr Ile Leu Lys Asp Leu Leu Pro Glu 195 200 205 Thr Ile Pro Pro Pro Glu Leu Asp Asp Met Thr Leu Trp Gln Ile Val 210 215 220 Ile Asn Ile Leu Ser Glu Pro Pro Lys Arg Lys Lys Arg Lys Asp Ile 225 230 235 240 Asn Thr Ile Glu Asp Ala Val Lys Leu Leu Gln Glu Cys Lys Lys Ile 245 250 255 Ile Val Leu Thr Gly Ala Gly Val Ser Val Ser Cys Gly Ile Pro Asp 260 265 270 Phe Arg Ser Arg Asp Gly Ile Tyr Ala Arg Leu Ala Val Asp Phe Pro 275 280 285 Asp Leu Pro Asp Pro Gln Ala Met Phe Asp Ile Glu Tyr Phe Arg Lys 290 295 300 Asp Pro Arg Pro Phe Phe Lys Phe Ala Lys Glu Ile Tyr Pro Gly Gln 305 310 315 320 Phe Gln Pro Ser Leu Cys His Lys Phe Ile Ala Leu Ser Asp Lys Glu 325 330 335 Gly Lys Leu Leu Arg Asn Tyr Thr Gln Asn Ile Asp Thr Leu Glu Gln 340 345 350 Val Ala Gly Ile Gln Arg Ile Ile Gln Cys His Gly Ser Phe Ala Thr 355 360 365 Ala Ser Cys Leu Ile Cys Lys Tyr Lys Val Asp Cys Glu Ala Val Arg 370 375 380 Gly Asp Ile Phe Asn Gln Val Val Pro Arg Cys Pro Arg Cys Pro Ala 385 390 395 400 Asp Glu Pro Leu Ala Ile Met Lys Pro Glu Ile Val Phe Phe Gly Glu 405 410 415 Asn Leu Pro Glu Gln Phe His Arg Ala Met Lys Tyr Asp Lys Asp Glu 420 425 430 Val Asp Leu Leu Ile Val Ile Gly Ser Ser Leu Lys Val Arg Pro Val 435 440 445 Ala Leu Ile Pro Ser Ser Ile Pro His Glu Val Pro Gln Ile Leu Ile 450 455 460 Asn Arg Glu Pro Leu Pro His Leu His Phe Asp Val Glu Leu Leu Gly 465 470 475 480 Asp Cys Asp Val Ile Ile Asn Glu Leu Cys His Arg Leu Gly Gly Glu 485 490 495 Tyr Ala Lys Leu Cys Cys Asn Pro Val Lys Leu Ser Glu Ile Thr Glu 500 505 510 Lys Pro Pro Arg Thr Gln Lys Glu Leu Ala Tyr Leu Ser Glu Leu Pro 515 520 525 Pro Thr Pro Leu His Val Ser Glu Asp Ser Ser Ser Pro Glu Arg Thr 530 535 540 Ser Pro Pro Asp Ser Ser Val Ile Val Thr Leu Leu Asp Gln Ala Ala 545 550 555 560 Lys Ser Asn Asp Asp Leu Asp Val Ser Glu Ser Lys Gly Cys Met Glu 565 570 575 Glu Lys Pro Gln Glu Val Gln Thr Ser Arg Asn Val Glu Ser Ile Ala 580 585 590 Glu Gln Met Glu Asn Pro Asp Leu Lys Asn Val Gly Ser Ser Thr Gly 595 600 605 Glu Lys Asn Glu Arg Thr Ser Val Ala Gly Thr Val Arg Lys Cys Trp 610 615 620 Pro Asn Arg Val Ala Lys Glu Gln Ile Ser Arg Arg Leu Asp Gly Asn 625 630 635 640 Gln Tyr Leu Phe Leu Pro Pro Asn Arg Tyr Ile Phe His Gly Ala Glu 645 650 655 Val Tyr Ser Asp Ser Glu Asp Asp Val Leu Ser Ser Ser Ser Cys Gly 660 665 670 Ser Asn Ser Asp Ser Gly Thr Cys Gln Ser Pro Ser Leu Glu Glu Pro 675 680 685 Met Glu Asp Glu Ser Glu Ile Glu Glu Phe Tyr Asn Gly Leu Glu Asp 690 695 700 Glu Pro Asp Val Pro Glu Arg Ala Gly Gly Ala Gly Phe Gly Thr Asp 705 710 715 720 Gly Asp Asp Gln Glu Ala Ile Asn Glu Ala Ile Ser Val Lys Gln Glu 725 730 735 Val Thr Asp Met Asn Tyr Pro Ser Asn Lys Ser 740 745 <210> 926 <211> 747 <212> PRT <213> Homo sapiens <400> 926 Met Ala Asp Glu Ala Ala Leu Ala Leu Gln Pro Gly Gly Ser Pro Ser 1 5 10 15 Ala Ala Gly Ala Asp Arg Glu Ala Ala Ser Ser Pro Ala Gly Glu Pro 20 25 30 Leu Arg Lys Arg Pro Arg Arg Asp Gly Pro Gly Leu Glu Arg Ser Pro 35 40 45 Gly Glu Pro Gly Gly Ala Ala Pro Glu Arg Glu Val Pro Ala Ala Ala 50 55 60 Arg Gly Cys Pro Gly Ala Ala Ala Ala Ala Leu Trp Arg Glu Ala Glu 65 70 75 80 Ala Glu Ala Ala Ala Ala Gly Gly Glu Gln Glu Ala Gln Ala Thr Ala 85 90 95 Ala Ala Gly Glu Gly Asp Asn Gly Pro Gly Leu Gln Gly Pro Ser Arg 100 105 110 Glu Pro Pro Leu Ala Asp Asn Leu Tyr Asp Glu Asp Asp Asp Asp Glu 115 120 125 Gly Glu Glu Glu Glu Glu Ala Ala Ala Ala Ala Ile Gly Tyr Arg Asp 130 135 140 Asn Leu Leu Phe Gly Asp Glu Ile Ile Thr Asn Gly Phe His Ser Cys 145 150 155 160 Glu Ser Asp Glu Glu Asp Arg Ala Ser His Ala Ser Ser Ser Asp Trp 165 170 175 Thr Pro Arg Pro Arg Ile Gly Pro Tyr Thr Phe Val Gln Gln His Leu 180 185 190 Met Ile Gly Thr Asp Pro Arg Thr Ile Leu Lys Asp Leu Leu Pro Glu 195 200 205 Thr Ile Pro Pro Pro Glu Leu Asp Asp Met Thr Leu Trp Gln Ile Val 210 215 220 Ile Asn Ile Leu Ser Glu Pro Pro Lys Arg Lys Lys Arg Lys Asp Ile 225 230 235 240 Asn Thr Ile Glu Asp Ala Val Lys Leu Leu Gln Glu Cys Lys Lys Ile 245 250 255 Ile Val Leu Thr Gly Ala Gly Val Ser Val Ser Cys Gly Ile Pro Asp 260 265 270 Phe Arg Ser Arg Asp Gly Ile Tyr Ala Arg Leu Ala Val Asp Phe Pro 275 280 285 Asp Leu Pro Asp Pro Gln Ala Met Phe Asp Ile Glu Tyr Phe Arg Lys 290 295 300 Asp Pro Arg Pro Phe Phe Lys Phe Ala Lys Glu Ile Tyr Pro Gly Gln 305 310 315 320 Phe Gln Pro Ser Leu Cys His Lys Phe Ile Ala Leu Ser Asp Lys Glu 325 330 335 Gly Lys Leu Leu Arg Asn Tyr Thr Gln Asn Ile Asp Thr Leu Glu Gln 340 345 350 Val Ala Gly Ile Gln Arg Ile Ile Gln Cys His Gly Ser Phe Ala Thr 355 360 365 Ala Ser Cys Leu Ile Cys Lys Tyr Lys Val Asp Cys Glu Ala Val Arg 370 375 380 Gly Asp Ile Phe Asn Gln Val Val Pro Arg Cys Pro Arg Cys Pro Ala 385 390 395 400 Asp Glu Pro Leu Ala Ile Met Lys Pro Glu Ile Val Phe Phe Gly Glu 405 410 415 Asn Leu Pro Glu Gln Phe His Arg Ala Met Lys Tyr Asp Lys Asp Glu 420 425 430 Val Asp Leu Leu Ile Val Ile Gly Ser Ser Leu Lys Val Arg Pro Val 435 440 445 Ala Leu Ile Pro Ser Ser Ile Pro His Glu Val Pro Gln Ile Leu Ile 450 455 460 Asn Arg Glu Pro Leu Pro His Leu His Phe Asp Val Glu Leu Leu Gly 465 470 475 480 Asp Cys Asp Val Ile Ile Asn Glu Leu Cys His Arg Leu Gly Gly Glu 485 490 495 Tyr Ala Lys Leu Cys Cys Asn Pro Val Lys Leu Ser Glu Ile Thr Glu 500 505 510 Lys Pro Pro Arg Thr Gln Lys Glu Leu Ala Tyr Leu Ser Glu Leu Pro 515 520 525 Pro Thr Pro Leu His Val Ser Glu Asp Ser Ser Ser Pro Glu Arg Thr 530 535 540 Ser Pro Pro Asp Ser Ser Val Ile Val Thr Leu Leu Asp Gln Ala Ala 545 550 555 560 Lys Ser Asn Asp Asp Leu Asp Val Ser Glu Ser Lys Gly Cys Met Glu 565 570 575 Glu Lys Pro Gln Glu Val Gln Thr Ser Arg Asn Val Glu Ser Ile Ala 580 585 590 Glu Gln Met Glu Asn Pro Asp Leu Lys Asn Val Gly Ser Ser Thr Gly 595 600 605 Glu Lys Asn Glu Arg Thr Ser Val Ala Gly Thr Val Arg Lys Cys Trp 610 615 620 Pro Asn Arg Val Ala Lys Glu Gln Ile Ser Arg Arg Leu Asp Gly Asn 625 630 635 640 Gln Tyr Leu Phe Leu Pro Pro Asn Arg Tyr Ile Phe His Gly Ala Glu 645 650 655 Val Tyr Ser Asp Ser Glu Asp Asp Val Leu Ser Ser Ser Ser Cys Gly 660 665 670 Ser Asn Ser Asp Ser Gly Thr Cys Gln Ser Pro Ser Leu Glu Glu Pro 675 680 685 Met Glu Asp Glu Ser Glu Ile Glu Glu Phe Tyr Asn Gly Leu Glu Asp 690 695 700 Glu Pro Asp Val Pro Glu Arg Ala Gly Gly Ala Gly Phe Gly Thr Asp 705 710 715 720 Gly Asp Asp Gln Glu Ala Ile Asn Glu Ala Ile Ser Val Lys Gln Glu 725 730 735 Val Thr Asp Met Asn Tyr Pro Ser Asn Lys Ser 740 745 <210> 927 <211> 555 <212> PRT <213> Homo sapiens <400> 927 Met Ile Gly Thr Asp Pro Arg Thr Ile Leu Lys Asp Leu Leu Pro Glu 1 5 10 15 Thr Ile Pro Pro Pro Glu Leu Asp Asp Met Thr Leu Trp Gln Ile Val 20 25 30 Ile Asn Ile Leu Ser Glu Pro Pro Lys Arg Lys Lys Arg Lys Asp Ile 35 40 45 Asn Thr Ile Glu Asp Ala Val Lys Leu Leu Gln Glu Cys Lys Lys Ile 50 55 60 Ile Val Leu Thr Gly Ala Gly Val Ser Val Ser Cys Gly Ile Pro Asp 65 70 75 80 Phe Arg Ser Arg Asp Gly Ile Tyr Ala Arg Leu Ala Val Asp Phe Pro 85 90 95 Asp Leu Pro Asp Pro Gln Ala Met Phe Asp Ile Glu Tyr Phe Arg Lys 100 105 110 Asp Pro Arg Pro Phe Phe Lys Phe Ala Lys Glu Ile Tyr Pro Gly Gln 115 120 125 Phe Gln Pro Ser Leu Cys His Lys Phe Ile Ala Leu Ser Asp Lys Glu 130 135 140 Gly Lys Leu Leu Arg Asn Tyr Thr Gln Asn Ile Asp Thr Leu Glu Gln 145 150 155 160 Val Ala Gly Ile Gln Arg Ile Ile Gln Cys His Gly Ser Phe Ala Thr 165 170 175 Ala Ser Cys Leu Ile Cys Lys Tyr Lys Val Asp Cys Glu Ala Val Arg 180 185 190 Gly Ala Leu Phe Ser Gln Val Val Pro Arg Cys Pro Arg Cys Pro Ala 195 200 205 Asp Glu Pro Leu Ala Ile Met Lys Pro Glu Ile Val Phe Phe Gly Glu 210 215 220 Asn Leu Pro Glu Gln Phe His Arg Ala Met Lys Tyr Asp Lys Asp Glu 225 230 235 240 Val Asp Leu Leu Ile Val Ile Gly Ser Ser Leu Lys Val Arg Pro Val 245 250 255 Ala Leu Ile Pro Ser Ser Ile Pro His Glu Val Pro Gln Ile Leu Ile 260 265 270 Asn Arg Glu Pro Leu Pro His Leu His Phe Asp Val Glu Leu Leu Gly 275 280 285 Asp Cys Asp Val Ile Ile Asn Glu Leu Cys His Arg Leu Gly Gly Glu 290 295 300 Tyr Ala Lys Leu Cys Cys Asn Pro Val Lys Leu Ser Glu Ile Thr Glu 305 310 315 320 Lys Pro Pro Arg Thr Gln Lys Glu Leu Ala Tyr Leu Ser Glu Leu Pro 325 330 335 Pro Thr Pro Leu His Val Ser Glu Asp Ser Ser Ser Pro Glu Arg Thr 340 345 350 Ser Pro Pro Asp Ser Ser Val Ile Val Thr Leu Leu Asp Gln Ala Ala 355 360 365 Lys Ser Asn Asp Asp Leu Asp Val Ser Glu Ser Lys Gly Cys Met Glu 370 375 380 Glu Lys Pro Gln Glu Val Gln Thr Ser Arg Asn Val Glu Ser Ile Ala 385 390 395 400 Glu Gln Met Glu Asn Pro Asp Leu Lys Asn Val Gly Ser Ser Thr Gly 405 410 415 Glu Lys Asn Glu Arg Thr Ser Val Ala Gly Thr Val Arg Lys Cys Trp 420 425 430 Pro Asn Arg Val Ala Lys Glu Gln Ile Ser Arg Arg Leu Asp Gly Asn 435 440 445 Gln Tyr Leu Phe Leu Pro Pro Asn Arg Tyr Ile Phe His Gly Ala Glu 450 455 460 Val Tyr Ser Asp Ser Glu Asp Asp Val Leu Ser Ser Ser Ser Cys Gly 465 470 475 480 Ser Asn Ser Asp Ser Gly Thr Cys Gln Ser Pro Ser Leu Glu Glu Pro 485 490 495 Met Glu Asp Glu Ser Glu Ile Glu Glu Phe Tyr Asn Gly Leu Glu Asp 500 505 510 Glu Pro Asp Val Pro Glu Arg Ala Gly Gly Ala Gly Phe Gly Thr Asp 515 520 525 Gly Asp Asp Gln Glu Ala Ile Asn Glu Ala Ile Ser Val Lys Gln Glu 530 535 540 Val Thr Asp Met Asn Tyr Pro Ser Asn Lys Ser 545 550 555 <210> 928 <211> 2120 <212> PRT <213> Homo sapiens <400> 928 Met Arg Ser Phe Lys Arg Val Asn Phe Gly Thr Leu Leu Ser Ser Gln 1 5 10 15 Lys Glu Ala Glu Glu Leu Leu Pro Asp Leu Lys Glu Phe Leu Ser Asn 20 25 30 Pro Pro Ala Gly Phe Pro Ser Ser Arg Ser Asp Ala Glu Arg Arg Gln 35 40 45 Ala Cys Asp Ala Ile Leu Arg Ala Cys Asn Gln Gln Leu Thr Ala Lys 50 55 60 Leu Ala Cys Pro Arg His Leu Gly Ser Leu Leu Glu Leu Ala Glu Leu 65 70 75 80 Ala Cys Asp Gly Tyr Leu Val Ser Thr Pro Gln Arg Pro Pro Leu Tyr 85 90 95 Leu Glu Arg Ile Leu Phe Val Leu Leu Arg Asn Ala Ala Ala Gln Gly 100 105 110 Ser Pro Glu Ala Thr Leu Arg Leu Ala Gln Pro Leu His Ala Cys Leu 115 120 125 Val Gln Cys Ser Arg Glu Ala Ala Pro Gln Asp Tyr Glu Ala Val Ala 130 135 140 Arg Gly Ser Phe Ser Leu Leu Trp Lys Gly Ala Glu Ala Leu Leu Glu 145 150 155 160 Arg Arg Ala Ala Phe Ala Ala Arg Leu Lys Ala Leu Ser Phe Leu Val 165 170 175 Leu Leu Glu Asp Glu Ser Thr Pro Cys Glu Val Pro His Phe Ala Ser 180 185 190 Pro Thr Ala Cys Arg Ala Val Ala Ala His Gln Leu Phe Asp Ala Ser 195 200 205 Gly His Gly Leu Asn Glu Ala Asp Ala Asp Phe Leu Asp Asp Leu Leu 210 215 220 Ser Arg His Val Ile Arg Ala Leu Val Gly Glu Arg Gly Ser Ser Ser 225 230 235 240 Gly Leu Leu Ser Pro Gln Arg Ala Leu Cys Leu Leu Glu Leu Thr Leu 245 250 255 Glu His Cys Arg Arg Phe Cys Trp Ser Arg His His Asp Lys Ala Ile 260 265 270 Ser Ala Val Glu Lys Ala His Ser Tyr Leu Arg Asn Thr Asn Leu Ala 275 280 285 Pro Ser Leu Gln Leu Cys Gln Leu Gly Val Lys Leu Leu Gln Val Gly 290 295 300 Glu Glu Gly Pro Gln Ala Val Ala Lys Leu Leu Ile Lys Ala Ser Ala 305 310 315 320 Val Leu Ser Lys Ser Met Glu Ala Pro Ser Pro Pro Leu Arg Ala Leu 325 330 335 Tyr Glu Ser Cys Gln Phe Phe Leu Ser Gly Leu Glu Arg Gly Thr Lys 340 345 350 Arg Arg Tyr Arg Leu Asp Ala Ile Leu Ser Leu Phe Ala Phe Leu Gly 355 360 365 Gly Tyr Cys Ser Leu Leu Gln Gln Leu Arg Asp Asp Gly Val Tyr Gly 370 375 380 Gly Ser Ser Lys Gln Gln Gln Ser Phe Leu Gln Met Tyr Phe Gln Gly 385 390 395 400 Leu His Leu Tyr Thr Val Val Val Tyr Asp Phe Ala Gln Gly Cys Gln 405 410 415 Ile Val Asp Leu Ala Asp Leu Thr Gln Leu Val Asp Ser Cys Lys Ser 420 425 430 Thr Val Val Trp Met Leu Glu Ala Leu Glu Gly Leu Ser Gly Gln Glu 435 440 445 Leu Thr Asp His Met Gly Met Thr Ala Ser Tyr Thr Ser Asn Leu Ala 450 455 460 Tyr Ser Phe Tyr Ser His Lys Leu Tyr Ala Glu Ala Cys Ala Ile Ser 465 470 475 480 Glu Pro Leu Cys Gln His Leu Gly Leu Val Lys Pro Gly Thr Tyr Pro 485 490 495 Glu Val Pro Pro Glu Lys Leu His Arg Cys Phe Arg Leu Gln Val Glu 500 505 510 Ser Leu Lys Lys Leu Gly Lys Gln Ala Gln Gly Cys Lys Met Val Ile 515 520 525 Leu Trp Leu Ala Ala Leu Gln Pro Cys Ser Pro Glu His Met Ala Glu 530 535 540 Pro Val Thr Phe Trp Val Arg Val Lys Met Asp Ala Ala Arg Ala Gly 545 550 555 560 Asp Lys Glu Leu Gln Leu Lys Thr Leu Arg Asp Ser Leu Ser Gly Trp 565 570 575 Asp Pro Glu Thr Leu Ala Leu Leu Leu Arg Glu Glu Leu Gln Ala Tyr 580 585 590 Lys Ala Val Arg Ala Asp Thr Gly Gln Glu Arg Phe Asn Ile Ile Cys 595 600 605 Asp Leu Leu Glu Leu Ser Pro Glu Glu Thr Pro Ala Gly Ala Trp Ala 610 615 620 Arg Ala Thr His Leu Val Glu Leu Ala Gln Val Leu Cys Tyr His Asp 625 630 635 640 Phe Thr Gln Gln Thr Asn Cys Ser Ala Leu Asp Ala Ile Arg Glu Ala 645 650 655 Leu Gln Leu Leu Asp Ser Val Arg Pro Glu Ala Gln Ala Arg Asp Gln 660 665 670 Leu Leu Asp Asp Lys Ala Gln Ala Leu Leu Trp Leu Tyr Ile Cys Thr 675 680 685 Leu Glu Ala Lys Ile Gln Glu Gly Ile Glu Arg Asp Arg Arg Ala Gln 690 695 700 Ala Pro Gly Asn Leu Glu Glu Phe Glu Val Asn Asp Leu Asn Tyr Glu 705 710 715 720 Asp Lys Leu Gln Glu Asp Arg Phe Leu Tyr Ser Asn Ile Ala Phe Asn 725 730 735 Leu Ala Ala Asp Ala Ala Gln Ser Lys Cys Leu Asp Gln Ala Leu Ala 740 745 750 Leu Trp Lys Glu Leu Leu Thr Lys Gly Gln Ala Pro Ala Val Arg Cys 755 760 765 Leu Gln Gln Thr Ala Ala Ser Leu Gln Ile Leu Ala Ala Leu Tyr Gln 770 775 780 Leu Val Ala Lys Pro Met Gln Ala Leu Glu Val Leu Leu Leu Leu Arg 785 790 795 800 Ile Val Ser Glu Arg Leu Lys Asp His Ser Lys Ala Ala Gly Ser Ser 805 810 815 Cys His Ile Thr Gln Leu Leu Leu Thr Leu Gly Cys Pro Ser Tyr Ala 820 825 830 Gln Leu His Leu Glu Glu Ala Ala Ser Ser Leu Lys His Leu Asp Gln 835 840 845 Thr Thr Asp Thr Tyr Leu Leu Leu Ser Leu Thr Cys Asp Leu Leu Arg 850 855 860 Ser Gln Leu Tyr Trp Thr His Gln Lys Val Thr Lys Gly Val Ser Leu 865 870 875 880 Leu Leu Ser Val Leu Arg Asp Pro Ala Leu Gln Lys Ser Ser Lys Ala 885 890 895 Trp Tyr Leu Leu Arg Val Gln Val Leu Gln Leu Val Ala Ala Tyr Leu 900 905 910 Ser Leu Pro Ser Asn Asn Leu Ser His Ser Leu Trp Glu Gln Leu Cys 915 920 925 Ala Gln Gly Trp Gln Thr Pro Glu Ile Ala Leu Ile Asp Ser His Lys 930 935 940 Leu Leu Arg Ser Ile Ile Leu Leu Leu Met Gly Ser Asp Ile Leu Ser 945 950 955 960 Thr Gln Lys Ala Ala Val Glu Thr Ser Phe Leu Asp Tyr Gly Glu Asn 965 970 975 Leu Val Gln Lys Trp Gln Val Leu Ser Glu Val Leu Ser Cys Ser Glu 980 985 990 Lys Leu Val Cys His Leu Gly Arg Leu Gly Ser Val Ser Glu Ala Lys 995 1000 1005 Ala Phe Cys Leu Glu Ala Leu Lys Leu Thr Thr Lys Leu Gln Ile 1010 1015 1020 Pro Arg Gln Cys Ala Leu Phe Leu Val Leu Lys Gly Glu Leu Glu 1025 1030 1035 Leu Ala Arg Asn Asp Ile Asp Leu Cys Gln Ser Asp Leu Gln Gln 1040 1045 1050 Val Leu Phe Leu Leu Glu Ser Cys Thr Glu Phe Gly Gly Val Thr 1055 1060 1065 Gln His Leu Asp Ser Val Lys Lys Val His Leu Gln Lys Gly Lys 1070 1075 1080 Gln Gln Ala Gln Val Pro Cys Pro Pro Gln Leu Pro Glu Glu Glu 1085 1090 1095 Leu Phe Leu Arg Gly Pro Ala Leu Glu Leu Val Ala Thr Val Ala 1100 1105 1110 Lys Glu Pro Gly Pro Ile Ala Pro Ser Thr Asn Ser Ser Pro Val 1115 1120 1125 Leu Lys Thr Lys Pro Gln Pro Ile Pro Asn Phe Leu Ser His Ser 1130 1135 1140 Pro Thr Cys Asp Cys Ser Leu Cys Ala Ser Pro Val Leu Thr Ala 1145 1150 1155 Val Cys Leu Arg Trp Val Leu Val Thr Ala Gly Val Arg Leu Ala 1160 1165 1170 Met Gly His Gln Ala Gln Gly Leu Asp Leu Leu Gln Val Val Leu 1175 1180 1185 Lys Gly Cys Pro Glu Ala Ala Glu Arg Leu Thr Gln Ala Leu Gln 1190 1195 1200 Ala Ser Leu Asn His Lys Thr Pro Pro Ser Leu Val Pro Ser Leu 1205 1210 1215 Leu Asp Glu Ile Leu Ala Gln Ala Tyr Thr Leu Leu Ala Leu Glu 1220 1225 1230 Gly Leu Asn Gln Pro Ser Asn Glu Ser Leu Gln Lys Val Leu Gln 1235 1240 1245 Ser Gly Leu Lys Phe Val Ala Ala Arg Ile Pro His Leu Glu Pro 1250 1255 1260 Trp Arg Ala Ser Leu Leu Leu Ile Trp Ala Leu Thr Lys Leu Gly 1265 1270 1275 Gly Leu Ser Cys Cys Thr Thr Gln Leu Phe Ala Ser Ser Trp Gly 1280 1285 1290 Trp Gln Pro Pro Leu Ile Lys Ser Val Pro Gly Ser Glu Pro Ser 1295 1300 1305 Lys Thr Gln Gly Gln Lys Arg Ser Gly Arg Gly Arg Gln Lys Leu 1310 1315 1320 Ala Ser Ala Pro Leu Arg Leu Asn Asn Thr Ser Gln Lys Gly Leu 1325 1330 1335 Glu Gly Arg Gly Leu Pro Cys Thr Pro Lys Pro Pro Asp Arg Ile 1340 1345 1350 Arg Gln Ala Gly Pro His Val Pro Phe Thr Val Phe Glu Glu Val 1355 1360 1365 Cys Pro Thr Glu Ser Lys Pro Glu Val Pro Gln Ala Pro Arg Val 1370 1375 1380 Gln Gln Arg Val Gln Thr Arg Leu Lys Val Asn Phe Ser Asp Asp 1385 1390 1395 Ser Asp Leu Glu Asp Pro Val Ser Ala Glu Ala Trp Leu Ala Glu 1400 1405 1410 Glu Pro Lys Arg Arg Gly Thr Ala Ser Arg Gly Arg Gly Arg Ala 1415 1420 1425 Arg Lys Gly Leu Ser Leu Lys Thr Asp Ala Val Val Ala Pro Gly 1430 1435 1440 Ser Ala Pro Gly Asn Pro Gly Leu Asn Gly Arg Ser Arg Arg Ala 1445 1450 1455 Lys Lys Val Ala Ser Arg His Cys Glu Glu Arg Arg Pro Gln Arg 1460 1465 1470 Ala Ser Asp Gln Ala Arg Pro Gly Pro Glu Ile Met Arg Thr Ile 1475 1480 1485 Pro Glu Glu Glu Leu Thr Asp Asn Trp Arg Lys Met Ser Phe Glu 1490 1495 1500 Ile Leu Arg Gly Ser Asp Gly Glu Asp Ser Ala Ser Gly Gly Lys 1505 1510 1515 Thr Pro Ala Pro Gly Pro Glu Ala Ala Ser Gly Glu Trp Glu Leu 1520 1525 1530 Leu Arg Leu Asp Ser Ser Lys Lys Lys Leu Pro Ser Pro Cys Pro 1535 1540 1545 Asp Lys Glu Ser Asp Lys Asp Leu Gly Pro Arg Leu Gln Leu Pro 1550 1555 1560 Ser Ala Pro Val Ala Thr Gly Leu Ser Thr Leu Asp Ser Ile Cys 1565 1570 1575 Asp Ser Leu Ser Val Ala Phe Arg Gly Ile Ser His Cys Pro Pro 1580 1585 1590 Ser Gly Leu Tyr Ala His Leu Cys Arg Phe Leu Ala Leu Cys Leu 1595 1600 1605 Gly His Arg Asp Pro Tyr Ala Thr Ala Phe Leu Val Thr Glu Ser 1610 1615 1620 Val Ser Ile Thr Cys Arg His Gln Leu Leu Thr His Leu His Arg 1625 1630 1635 Gln Leu Ser Lys Ala Gln Lys His Arg Gly Ser Leu Glu Ile Ala 1640 1645 1650 Asp Gln Leu Gln Gly Leu Ser Leu Gln Glu Met Pro Gly Asp Val 1655 1660 1665 Pro Leu Ala Arg Ile Gln Arg Leu Phe Ser Phe Arg Ala Leu Glu 1670 1675 1680 Ser Gly His Phe Pro Gln Pro Glu Lys Glu Ser Phe Gln Glu Arg 1685 1690 1695 Leu Ala Leu Ile Pro Ser Gly Val Thr Val Cys Val Leu Ala Leu 1700 1705 1710 Ala Thr Leu Gln Pro Gly Thr Val Gly Asn Thr Leu Leu Leu Thr 1715 1720 1725 Arg Leu Glu Lys Asp Ser Pro Pro Val Ser Val Gln Ile Pro Thr 1730 1735 1740 Gly Gln Asn Lys Leu His Leu Arg Ser Val Leu Asn Glu Phe Asp 1745 1750 1755 Ala Ile Gln Lys Ala Gln Lys Glu Asn Ser Ser Cys Thr Asp Lys 1760 1765 1770 Arg Glu Trp Trp Thr Gly Arg Leu Ala Leu Asp His Arg Met Glu 1775 1780 1785 Val Leu Ile Ala Ser Leu Glu Lys Ser Val Leu Gly Cys Trp Lys 1790 1795 1800 Gly Leu Leu Leu Pro Ser Ser Glu Glu Pro Gly Pro Ala Gln Glu 1805 1810 1815 Ala Ser Arg Leu Gln Glu Leu Leu Gln Asp Cys Gly Trp Lys Tyr 1820 1825 1830 Pro Asp Arg Thr Leu Leu Lys Ile Met Leu Ser Gly Ala Gly Ala 1835 1840 1845 Leu Thr Pro Gln Asp Ile Gln Ala Leu Ala Tyr Gly Leu Cys Pro 1850 1855 1860 Thr Gln Pro Glu Arg Ala Gln Glu Leu Leu Asn Glu Ala Val Gly 1865 1870 1875 Arg Leu Gln Gly Leu Thr Val Pro Ser Asn Ser His Leu Val Leu 1880 1885 1890 Val Leu Asp Lys Asp Leu Gln Lys Leu Pro Trp Glu Ser Met Pro 1895 1900 1905 Ser Leu Gln Ala Leu Pro Val Thr Arg Leu Pro Ser Phe Arg Phe 1910 1915 1920 Leu Leu Ser Tyr Ser Ile Ile Lys Glu Tyr Gly Ala Ser Pro Val 1925 1930 1935 Leu Ser Gln Gly Val Asp Pro Arg Ser Thr Phe Tyr Val Leu Asn 1940 1945 1950 Pro His Asn Asn Leu Ser Ser Thr Glu Glu Gln Phe Arg Ala Asn 1955 1960 1965 Phe Ser Ser Glu Ala Gly Trp Arg Gly Val Val Gly Glu Val Pro 1970 1975 1980 Arg Pro Glu Gln Val Gln Glu Ala Leu Thr Lys His Asp Leu Tyr 1985 1990 1995 Ile Tyr Ala Gly His Gly Ala Gly Ala Arg Phe Leu Asp Gly Gln 2000 2005 2010 Ala Val Leu Arg Leu Ser Cys Arg Ala Val Ala Leu Leu Phe Gly 2015 2020 2025 Cys Ser Ser Ala Ala Leu Ala Val His Gly Asn Leu Glu Gly Ala 2030 2035 2040 Gly Ile Val Leu Lys Tyr Ile Met Ala Gly Cys Pro Leu Phe Leu 2045 2050 2055 Gly Asn Leu Trp Asp Val Thr Asp Arg Asp Ile Asp Arg Tyr Thr 2060 2065 2070 Glu Ala Leu Leu Gln Gly Trp Leu Gly Ala Gly Pro Gly Ala Pro 2075 2080 2085 Leu Leu Tyr Tyr Val Asn Gln Ala Arg Gln Ala Pro Arg Leu Lys 2090 2095 2100 Tyr Leu Ile Gly Ala Ala Pro Ile Ala Tyr Gly Leu Pro Val Ser 2105 2110 2115 Leu Arg 2120 <210> 929 <211> 871 <212> PRT <213> Homo sapiens <400> 929 Ser Leu Leu Gln Gln Leu Arg Asp Asp Gly Val Tyr Gly Gly Ser Ser 1 5 10 15 Lys Gln Gln Gln Ser Phe Leu Gln Met Tyr Phe Gln Gly Leu His Leu 20 25 30 Tyr Thr Val Val Val Tyr Asp Phe Ala Gln Gly Cys Gln Ile Val Asp 35 40 45 Leu Ala Asp Leu Thr Gln Leu Val Asp Ser Cys Lys Ser Thr Val Val 50 55 60 Trp Met Leu Glu Ala Leu Glu Gly Leu Ser Gly Gln Glu Leu Thr Asp 65 70 75 80 His Met Gly Met Thr Ala Ser Tyr Thr Ser Asn Leu Ala Tyr Ser Phe 85 90 95 Tyr Ser His Lys Leu Tyr Ala Glu Ala Cys Ala Ile Ser Glu Pro Leu 100 105 110 Cys Gln His Leu Gly Leu Val Lys Pro Gly Thr Tyr Pro Glu Val Pro 115 120 125 Pro Glu Lys Leu His Arg Cys Phe Arg Leu Gln Val Glu Ser Leu Lys 130 135 140 Lys Leu Gly Lys Gln Ala Gln Gly Cys Lys Met Val Ile Leu Trp Leu 145 150 155 160 Ala Ala Leu Gln Pro Cys Ser Pro Glu His Met Ala Glu Pro Val Thr 165 170 175 Phe Trp Val Arg Val Lys Met Asp Ala Ala Arg Ala Gly Asp Lys Glu 180 185 190 Leu Gln Leu Lys Thr Leu Arg Asp Ser Leu Ser Gly Trp Asp Pro Glu 195 200 205 Thr Leu Ala Leu Leu Leu Arg Glu Glu Leu Gln Ala Tyr Lys Ala Val 210 215 220 Arg Ala Asp Thr Gly Gln Glu Arg Phe Asn Ile Ile Cys Asp Leu Leu 225 230 235 240 Glu Leu Ser Pro Glu Glu Thr Pro Ala Gly Ala Trp Ala Arg Ala Thr 245 250 255 His Leu Val Glu Leu Ala Gln Val Leu Cys Tyr His Asp Phe Thr Gln 260 265 270 Gln Thr Asn Cys Ser Ala Leu Asp Ala Ile Arg Glu Ala Leu Gln Leu 275 280 285 Leu Asp Ser Val Arg Pro Glu Ala Gln Ala Arg Asp Gln Leu Leu Asp 290 295 300 Asp Lys Ala Gln Ala Leu Leu Trp Leu Tyr Ile Cys Thr Leu Glu Ala 305 310 315 320 Lys Met Gln Glu Gly Ile Glu Arg Asp Arg Arg Ala Gln Ala Pro Gly 325 330 335 Asn Leu Glu Glu Phe Glu Val Asn Asp Leu Asn Tyr Glu Asp Lys Leu 340 345 350 Gln Glu Asp Arg Phe Leu Tyr Ser Asn Ile Ala Phe Asn Leu Ala Ala 355 360 365 Asp Ala Ala Gln Ser Lys Cys Leu Asp Gln Ala Leu Ala Leu Trp Lys 370 375 380 Glu Leu Leu Thr Lys Gly Gln Ala Pro Ala Val Arg Cys Leu Gln Gln 385 390 395 400 Thr Ala Ala Ser Leu Gln Ile Leu Ala Ala Leu Tyr Gln Leu Val Ala 405 410 415 Lys Pro Met Gln Ala Leu Glu Val Leu Leu Leu Leu Arg Ile Val Ser 420 425 430 Glu Arg Leu Lys Asp His Ser Lys Ala Ala Gly Ser Ser Cys His Ile 435 440 445 Thr Gln Leu Leu Leu Thr Leu Gly Cys Pro Ser Tyr Ala Gln Leu His 450 455 460 Leu Glu Glu Ala Ala Ser Ser Leu Lys His Leu Asp Gln Thr Thr Asp 465 470 475 480 Thr Tyr Leu Leu Leu Ser Leu Thr Cys Asp Leu Leu Arg Ser Gln Leu 485 490 495 Tyr Trp Thr His Gln Lys Val Thr Lys Gly Val Ser Leu Leu Leu Ser 500 505 510 Val Leu Arg Asp Pro Ala Leu Gln Lys Ser Ser Lys Ala Trp Tyr Leu 515 520 525 Leu Arg Val Gln Val Leu Gln Leu Val Ala Ala Tyr Leu Ser Leu Pro 530 535 540 Ser Asn Asn Leu Ser His Ser Leu Trp Glu Gln Leu Cys Ala Gln Gly 545 550 555 560 Trp Gln Thr Pro Glu Ile Ala Leu Ile Asp Ser His Lys Leu Leu Arg 565 570 575 Ser Ile Ile Leu Leu Leu Met Gly Ser Asp Ile Leu Ser Thr Gln Lys 580 585 590 Ala Ala Val Glu Thr Ser Phe Leu Asp Tyr Gly Glu Asn Leu Val Gln 595 600 605 Lys Trp Gln Val Leu Ser Glu Val Leu Ser Cys Ser Glu Lys Leu Val 610 615 620 Cys His Leu Gly Arg Leu Gly Ser Val Ser Glu Ala Lys Ala Phe Cys 625 630 635 640 Leu Glu Ala Leu Lys Leu Thr Thr Lys Leu Gln Ile Pro Arg Gln Cys 645 650 655 Ala Leu Phe Leu Val Leu Lys Gly Glu Leu Glu Leu Ala Arg Asn Asp 660 665 670 Ile Asp Leu Cys Gln Ser Asp Leu Gln Gln Val Leu Phe Leu Leu Glu 675 680 685 Ser Cys Thr Glu Phe Gly Gly Val Thr Gln His Leu Asp Ser Val Lys 690 695 700 Lys Val His Leu Gln Lys Gly Lys Gln Gln Ala Gln Val Pro Cys Pro 705 710 715 720 Pro Gln Leu Pro Glu Glu Glu Leu Phe Leu Arg Gly Pro Ala Leu Glu 725 730 735 Leu Val Ala Thr Val Ala Lys Glu Pro Gly Pro Ile Ala Pro Ser Thr 740 745 750 Asn Ser Ser Pro Val Leu Lys Thr Lys Pro Gln Pro Ile Pro Asn Phe 755 760 765 Leu Ser His Ser Pro Thr Cys Asp Cys Ser Leu Cys Ala Ser Pro Val 770 775 780 Leu Thr Ala Val Cys Leu Arg Trp Val Leu Val Thr Ala Gly Val Arg 785 790 795 800 Leu Ala Met Gly His Gln Ala Gln Gly Leu Asp Leu Leu Gln Val Val 805 810 815 Leu Lys Gly Cys Pro Glu Ala Ala Glu Arg Leu Thr Gln Ala Leu Gln 820 825 830 Ala Ser Leu Asn His Lys Thr Pro Pro Arg Arg Lys Tyr Gln Met Gln 835 840 845 Lys Lys Lys Lys Lys Thr Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys 850 855 860 Lys Lys Lys Lys Lys Lys Lys 865 870 <210> 930 <211> 2120 <212> PRT <213> Homo sapiens <400> 930 Met Arg Ser Phe Lys Arg Val Asn Phe Gly Thr Leu Leu Ser Ser Gln 1 5 10 15 Lys Glu Ala Glu Glu Leu Leu Pro Asp Leu Lys Glu Phe Leu Ser Asn 20 25 30 Pro Pro Ala Gly Phe Pro Ser Ser Arg Ser Asp Ala Glu Arg Arg Gln 35 40 45 Ala Cys Asp Ala Ile Leu Arg Ala Cys Asn Gln Gln Leu Thr Ala Lys 50 55 60 Leu Ala Cys Pro Arg His Leu Gly Ser Leu Leu Glu Leu Ala Glu Leu 65 70 75 80 Ala Cys Asp Gly Tyr Leu Val Ser Thr Pro Gln Arg Pro Pro Leu Tyr 85 90 95 Leu Glu Arg Ile Leu Phe Val Leu Leu Arg Asn Ala Ala Ala Gln Gly 100 105 110 Ser Pro Glu Val Thr Leu Arg Leu Ala Gln Pro Leu His Ala Cys Leu 115 120 125 Val Gln Cys Ser Arg Glu Ala Ala Pro Gln Asp Tyr Glu Ala Val Ala 130 135 140 Arg Gly Ser Phe Ser Leu Leu Trp Lys Gly Ala Glu Ala Leu Leu Glu 145 150 155 160 Arg Arg Ala Ala Phe Ala Ala Arg Leu Lys Ala Leu Ser Phe Leu Val 165 170 175 Leu Leu Glu Asp Glu Ser Thr Pro Cys Glu Val Pro His Phe Ala Ser 180 185 190 Pro Thr Ala Cys Arg Ala Val Ala Ala His Gln Leu Phe Asp Ala Ser 195 200 205 Gly His Gly Leu Asn Glu Ala Asp Ala Asp Phe Leu Asp Asp Leu Leu 210 215 220 Ser Arg His Val Ile Arg Ala Leu Val Gly Glu Arg Gly Ser Ser Ser 225 230 235 240 Gly Leu Leu Ser Pro Gln Arg Ala Leu Cys Leu Leu Glu Leu Thr Leu 245 250 255 Glu His Cys Arg Arg Phe Cys Trp Ser Arg His His Asp Lys Ala Ile 260 265 270 Ser Ala Val Glu Lys Ala His Ser Tyr Leu Arg Asn Thr Asn Leu Ala 275 280 285 Pro Ser Leu Gln Leu Cys Gln Leu Gly Val Lys Leu Leu Gln Val Gly 290 295 300 Glu Glu Gly Pro Gln Ala Val Ala Lys Leu Leu Ile Lys Ala Ser Ala 305 310 315 320 Val Leu Ser Lys Ser Met Glu Ala Pro Ser Pro Pro Leu Arg Ala Leu 325 330 335 Tyr Glu Ser Cys Gln Phe Phe Leu Ser Gly Leu Glu Arg Gly Thr Lys 340 345 350 Arg Arg Tyr Arg Leu Asp Ala Ile Leu Ser Leu Phe Ala Phe Leu Gly 355 360 365 Gly Tyr Cys Ser Leu Leu Gln Gln Leu Arg Asp Asp Gly Val Tyr Gly 370 375 380 Gly Ser Ser Lys Gln Gln Gln Ser Phe Leu Gln Met Tyr Phe Gln Gly 385 390 395 400 Leu His Leu Tyr Thr Val Val Val Tyr Asp Phe Ala Gln Gly Cys Gln 405 410 415 Ile Val Asp Leu Ala Asp Leu Thr Gln Leu Val Asp Ser Cys Lys Ser 420 425 430 Thr Val Val Trp Met Leu Glu Ala Leu Glu Gly Leu Ser Gly Gln Glu 435 440 445 Leu Thr Asp His Met Gly Met Thr Ala Ser Tyr Thr Ser Asn Leu Ala 450 455 460 Tyr Ser Phe Tyr Ser His Lys Leu Tyr Ala Glu Ala Cys Ala Ile Ser 465 470 475 480 Glu Pro Leu Cys Gln His Leu Gly Leu Val Lys Pro Gly Thr Tyr Pro 485 490 495 Glu Val Pro Pro Glu Lys Leu His Arg Cys Phe Arg Leu Gln Val Glu 500 505 510 Ser Leu Lys Lys Leu Gly Lys Gln Ala Gln Gly Cys Lys Met Val Ile 515 520 525 Leu Trp Leu Ala Ala Leu Gln Pro Cys Ser Pro Glu His Met Ala Glu 530 535 540 Pro Val Thr Phe Trp Val Arg Val Lys Met Asp Ala Ala Arg Ala Gly 545 550 555 560 Asp Lys Glu Leu Gln Leu Lys Thr Leu Arg Asp Ser Leu Ser Gly Trp 565 570 575 Asp Pro Glu Thr Leu Ala Leu Leu Leu Arg Glu Glu Leu Gln Ala Tyr 580 585 590 Lys Ala Val Arg Ala Asp Thr Gly Gln Glu Arg Phe Asn Ile Ile Cys 595 600 605 Asp Leu Leu Glu Leu Ser Pro Glu Glu Thr Pro Ala Gly Ala Trp Ala 610 615 620 Arg Ala Thr His Leu Val Glu Leu Ala Gln Val Leu Cys Tyr His Asp 625 630 635 640 Phe Thr Gln Gln Thr Asn Cys Ser Ala Leu Asp Ala Ile Arg Glu Ala 645 650 655 Leu Gln Leu Leu Asp Ser Val Arg Pro Glu Ala Gln Ala Arg Asp Gln 660 665 670 Leu Leu Asp Asp Lys Ala Gln Ala Leu Leu Trp Leu Tyr Ile Cys Thr 675 680 685 Leu Glu Ala Lys Ile Gln Glu Gly Ile Glu Arg Asp Arg Arg Ala Gln 690 695 700 Ala Pro Gly Asn Leu Glu Glu Phe Glu Val Asn Asp Leu Asn Tyr Glu 705 710 715 720 Asp Lys Leu Gln Glu Asp Arg Phe Leu Tyr Ser Asn Ile Ala Phe Asn 725 730 735 Leu Ala Ala Asp Ala Ala Gln Ser Lys Cys Leu Asp Gln Ala Leu Ala 740 745 750 Leu Trp Lys Glu Leu Leu Thr Lys Gly Gln Ala Pro Ala Val Arg Cys 755 760 765 Leu Gln Gln Thr Ala Ala Ser Leu Gln Ile Leu Ala Ala Leu Tyr Gln 770 775 780 Leu Val Ala Lys Pro Met Gln Ala Leu Glu Val Leu Leu Leu Leu Arg 785 790 795 800 Ile Val Ser Glu Arg Leu Lys Asp His Ser Lys Ala Ala Gly Ser Ser 805 810 815 Cys His Ile Thr Gln Leu Leu Leu Thr Leu Gly Cys Pro Ser Tyr Ala 820 825 830 Gln Leu His Leu Glu Glu Ala Ala Ser Ser Leu Lys His Leu Asp Gln 835 840 845 Thr Thr Asp Thr Tyr Leu Leu Leu Ser Leu Thr Cys Asp Leu Leu Arg 850 855 860 Ser Gln Leu Tyr Trp Thr His Gln Lys Val Thr Lys Gly Val Ser Leu 865 870 875 880 Leu Leu Ser Val Leu Arg Asp Pro Ala Leu Gln Lys Ser Ser Lys Ala 885 890 895 Trp Tyr Leu Leu Arg Val Gln Val Leu Gln Leu Val Ala Ala Tyr Leu 900 905 910 Ser Leu Pro Ser Asn Asn Leu Ser His Ser Leu Trp Glu Gln Leu Cys 915 920 925 Ala Gln Gly Trp Gln Thr Pro Glu Ile Ala Leu Ile Asp Ser His Lys 930 935 940 Leu Leu Arg Ser Ile Ile Leu Leu Leu Met Gly Ser Asp Ile Leu Ser 945 950 955 960 Thr Gln Lys Ala Ala Val Glu Thr Ser Phe Leu Asp Tyr Gly Glu Asn 965 970 975 Leu Val Gln Lys Trp Gln Val Leu Ser Glu Val Leu Ser Cys Ser Glu 980 985 990 Lys Leu Val Cys His Leu Gly Arg Leu Gly Ser Val Ser Glu Ala Lys 995 1000 1005 Ala Phe Cys Leu Glu Ala Leu Lys Leu Thr Thr Lys Leu Gln Ile 1010 1015 1020 Pro Arg Gln Cys Ala Leu Phe Leu Val Leu Lys Gly Glu Leu Glu 1025 1030 1035 Leu Ala Arg Asn Asp Ile Asp Leu Cys Gln Ser Asp Leu Gln Gln 1040 1045 1050 Val Leu Phe Leu Leu Glu Ser Cys Thr Glu Phe Gly Gly Val Thr 1055 1060 1065 Gln His Leu Asp Ser Val Lys Lys Val His Leu Gln Lys Gly Lys 1070 1075 1080 Gln Gln Ala Gln Val Pro Cys Pro Pro Gln Leu Pro Glu Glu Glu 1085 1090 1095 Leu Phe Leu Arg Gly Pro Ala Leu Glu Leu Val Ala Thr Val Ala 1100 1105 1110 Lys Glu Pro Gly Pro Ile Ala Pro Ser Thr Asn Ser Ser Pro Val 1115 1120 1125 Leu Lys Thr Lys Pro Gln Pro Ile Pro Asn Phe Leu Ser His Ser 1130 1135 1140 Pro Thr Cys Asp Cys Ser Leu Cys Ala Ser Pro Val Leu Thr Ala 1145 1150 1155 Val Cys Leu Arg Trp Val Leu Val Thr Ala Gly Val Arg Leu Ala 1160 1165 1170 Met Gly His Gln Ala Gln Gly Leu Asp Leu Leu Gln Val Val Leu 1175 1180 1185 Lys Gly Cys Pro Glu Ala Ala Glu Arg Leu Thr Gln Ala Leu Gln 1190 1195 1200 Ala Ser Leu Asn His Lys Thr Pro Pro Ser Leu Val Pro Ser Leu 1205 1210 1215 Leu Asp Glu Ile Leu Ala Gln Ala Tyr Thr Leu Leu Ala Leu Glu 1220 1225 1230 Gly Leu Asn Gln Pro Ser Asn Glu Ser Leu Gln Lys Val Leu Gln 1235 1240 1245 Ser Gly Leu Lys Phe Val Ala Ala Arg Ile Pro His Leu Glu Pro 1250 1255 1260 Trp Arg Ala Ser Leu Leu Leu Ile Trp Ala Leu Thr Lys Leu Gly 1265 1270 1275 Gly Leu Ser Cys Cys Thr Thr Gln Leu Phe Ala Ser Ser Trp Gly 1280 1285 1290 Trp Gln Pro Pro Leu Ile Lys Ser Val Pro Gly Ser Glu Pro Ser 1295 1300 1305 Lys Thr Gln Gly Gln Lys Arg Ser Gly Arg Gly Arg Gln Lys Leu 1310 1315 1320 Ala Ser Ala Pro Leu Ser Leu Asn Asn Thr Ser Gln Lys Gly Leu 1325 1330 1335 Glu Gly Arg Gly Leu Pro Cys Thr Pro Lys Pro Pro Asp Arg Ile 1340 1345 1350 Arg Gln Ala Gly Pro His Val Pro Phe Thr Val Phe Glu Glu Val 1355 1360 1365 Cys Pro Thr Glu Ser Lys Pro Glu Val Pro Gln Ala Pro Arg Val 1370 1375 1380 Gln Gln Arg Val Gln Thr Arg Leu Lys Val Asn Phe Ser Asp Asp 1385 1390 1395 Ser Asp Leu Glu Asp Pro Val Ser Ala Glu Ala Trp Leu Ala Glu 1400 1405 1410 Glu Pro Lys Arg Arg Gly Thr Ala Ser Arg Gly Arg Gly Arg Ala 1415 1420 1425 Arg Lys Gly Leu Ser Leu Lys Thr Asp Ala Val Val Ala Pro Gly 1430 1435 1440 Ser Ala Pro Gly Asn Pro Gly Leu Asn Gly Arg Ser Arg Arg Ala 1445 1450 1455 Lys Lys Val Ala Ser Arg His Cys Glu Glu Arg Arg Pro Gln Arg 1460 1465 1470 Ala Ser Asp Gln Ala Arg Pro Gly Pro Glu Ile Met Arg Thr Ile 1475 1480 1485 Pro Glu Glu Glu Leu Thr Asp Asn Trp Arg Lys Met Ser Phe Glu 1490 1495 1500 Ile Leu Arg Gly Ser Asp Gly Glu Asp Ser Ala Ser Gly Gly Lys 1505 1510 1515 Thr Pro Ala Pro Gly Pro Glu Ala Ala Ser Gly Glu Trp Glu Leu 1520 1525 1530 Leu Arg Leu Asp Ser Ser Lys Lys Lys Leu Pro Ser Pro Cys Pro 1535 1540 1545 Asp Lys Glu Ser Asp Lys Asp Leu Gly Pro Arg Leu Gln Leu Pro 1550 1555 1560 Ser Ala Pro Val Ala Thr Gly Leu Ser Thr Leu Asp Ser Ile Cys 1565 1570 1575 Asp Ser Leu Ser Val Ala Phe Arg Gly Ile Ser His Cys Pro Pro 1580 1585 1590 Ser Gly Leu Tyr Ala His Leu Cys Arg Phe Leu Ala Leu Cys Leu 1595 1600 1605 Gly His Arg Asp Pro Tyr Ala Thr Ala Phe Leu Val Thr Glu Ser 1610 1615 1620 Val Ser Ile Thr Cys Arg His Gln Leu Leu Thr His Leu His Arg 1625 1630 1635 Gln Leu Ser Lys Ala Gln Lys His Arg Gly Ser Leu Glu Ile Ala 1640 1645 1650 Asp Gln Leu Gln Gly Leu Ser Leu Gln Glu Met Pro Gly Asp Val 1655 1660 1665 Pro Leu Ala Arg Ile Gln Arg Leu Phe Ser Phe Arg Ala Leu Glu 1670 1675 1680 Ser Gly His Phe Pro Gln Pro Glu Lys Glu Ser Phe Gln Glu Arg 1685 1690 1695 Leu Ala Leu Ile Pro Ser Gly Val Thr Val Cys Val Leu Ala Leu 1700 1705 1710 Ala Thr Leu Gln Pro Gly Thr Val Gly Asn Thr Leu Leu Leu Thr 1715 1720 1725 Arg Leu Glu Lys Asp Ser Pro Pro Val Ser Val Gln Ile Pro Thr 1730 1735 1740 Gly Gln Asn Lys Leu His Leu Arg Ser Val Leu Asn Glu Phe Asp 1745 1750 1755 Ala Ile Gln Lys Ala Gln Lys Glu Asn Ser Ser Cys Thr Asp Lys 1760 1765 1770 Arg Glu Trp Trp Thr Gly Arg Leu Ala Leu Asp His Arg Met Glu 1775 1780 1785 Val Leu Ile Ala Ser Leu Glu Lys Ser Val Leu Gly Cys Trp Lys 1790 1795 1800 Gly Leu Leu Leu Pro Ser Ser Glu Glu Pro Gly Pro Ala Gln Glu 1805 1810 1815 Ala Ser Arg Leu Gln Glu Leu Leu Gln Asp Cys Gly Trp Lys Tyr 1820 1825 1830 Pro Asp Arg Thr Leu Leu Lys Ile Met Leu Ser Gly Ala Gly Ala 1835 1840 1845 Leu Thr Pro Gln Asp Ile Gln Ala Leu Ala Tyr Gly Leu Cys Pro 1850 1855 1860 Thr Gln Pro Glu Arg Ala Gln Glu Leu Leu Asn Glu Ala Val Gly 1865 1870 1875 Arg Leu Gln Gly Leu Thr Val Pro Ser Asn Ser His Leu Val Leu 1880 1885 1890 Val Leu Asp Lys Asp Leu Gln Lys Leu Pro Trp Glu Ser Met Pro 1895 1900 1905 Ser Leu Gln Ala Leu Pro Val Thr Arg Leu Pro Ser Phe Arg Phe 1910 1915 1920 Leu Leu Ser Tyr Ser Ile Ile Lys Glu Tyr Gly Ala Ser Pro Val 1925 1930 1935 Leu Ser Gln Gly Val Asp Pro Arg Ser Thr Phe Tyr Val Leu Asn 1940 1945 1950 Pro His Asn Asn Leu Ser Ser Thr Glu Glu Gln Phe Arg Ala Asn 1955 1960 1965 Phe Ser Ser Glu Ala Gly Trp Arg Gly Val Val Gly Glu Val Pro 1970 1975 1980 Arg Pro Glu Gln Val Gln Glu Ala Leu Thr Lys His Asp Leu Tyr 1985 1990 1995 Ile Tyr Ala Gly His Gly Ala Gly Ala Arg Phe Leu Asp Gly Gln 2000 2005 2010 Ala Val Leu Arg Leu Ser Cys Arg Ala Val Ala Leu Leu Phe Gly 2015 2020 2025 Cys Ser Ser Ala Ala Leu Ala Val His Gly Asn Leu Glu Gly Ala 2030 2035 2040 Gly Ile Val Leu Lys Tyr Ile Met Ala Gly Cys Pro Leu Phe Leu 2045 2050 2055 Gly Asn Leu Trp Asp Val Thr Asp Arg Asp Ile Asp Arg Tyr Thr 2060 2065 2070 Glu Ala Leu Leu Gln Gly Trp Leu Gly Ala Gly Pro Gly Ala Pro 2075 2080 2085 Leu Leu Tyr Tyr Val Asn Gln Ala Arg Gln Ala Pro Arg Leu Lys 2090 2095 2100 Tyr Leu Ile Gly Ala Ala Pro Ile Ala Tyr Gly Leu Pro Val Ser 2105 2110 2115 Leu Arg 2120 <210> 931 <211> 2093 <212> PRT <213> Homo sapiens <400> 931 Glu Phe Leu Ser Asn Pro Pro Ala Gly Phe Pro Ser Ser Arg Ser Asp 1 5 10 15 Ala Glu Arg Arg Gln Ala Cys Asp Ala Ile Leu Arg Ala Cys Asn Gln 20 25 30 Gln Leu Thr Ala Lys Leu Ala Cys Pro Arg His Leu Gly Ser Leu Leu 35 40 45 Glu Leu Ala Glu Leu Ala Cys Asp Gly Tyr Leu Val Ser Thr Pro Gln 50 55 60 Arg Pro Pro Leu Tyr Leu Glu Arg Ile Leu Phe Val Leu Leu Arg Asn 65 70 75 80 Ala Ala Ala Gln Gly Ser Pro Glu Ala Thr Leu Arg Leu Ala Gln Pro 85 90 95 Leu His Ala Cys Leu Val Gln Cys Ser Arg Glu Ala Ala Pro Gln Asp 100 105 110 Tyr Glu Ala Val Ala Arg Gly Ser Phe Ser Leu Leu Trp Lys Gly Ala 115 120 125 Glu Ala Leu Leu Glu Arg Arg Ala Ala Phe Ala Ala Arg Leu Lys Ala 130 135 140 Leu Ser Phe Leu Val Leu Leu Glu Asp Glu Ser Thr Pro Cys Glu Val 145 150 155 160 Pro His Phe Ala Ser Pro Thr Ala Cys Arg Ala Val Ala Ala His Gln 165 170 175 Leu Phe Asp Ala Ser Gly His Gly Leu Asn Glu Ala Asp Ala Asp Phe 180 185 190 Leu Asp Asp Leu Leu Ser Arg His Val Ile Arg Ala Leu Val Gly Glu 195 200 205 Arg Gly Ser Ser Ser Gly Leu Leu Ser Pro Gln Arg Ala Leu Cys Leu 210 215 220 Leu Glu Leu Thr Leu Glu His Cys Arg Arg Phe Cys Trp Ser Arg His 225 230 235 240 His Asp Lys Ala Ile Ser Ala Val Glu Lys Ala His Ser Tyr Leu Arg 245 250 255 Asn Thr Asn Leu Ala Pro Ser Leu Gln Leu Cys Gln Leu Gly Val Lys 260 265 270 Leu Leu Gln Val Gly Glu Glu Gly Pro Gln Ala Val Ala Lys Leu Leu 275 280 285 Ile Lys Ala Ser Ala Val Leu Ser Lys Ser Met Glu Ala Pro Ser Pro 290 295 300 Pro Leu Arg Ala Leu Tyr Glu Ser Cys Gln Phe Phe Leu Ser Gly Leu 305 310 315 320 Glu Arg Gly Thr Lys Arg Arg Tyr Arg Leu Asp Ala Ile Leu Ser Leu 325 330 335 Phe Ala Phe Leu Gly Gly Tyr Cys Ser Leu Leu Gln Gln Leu Arg Asp 340 345 350 Asp Gly Val Tyr Gly Gly Ser Ser Lys Gln Gln Gln Ser Phe Leu Gln 355 360 365 Met Tyr Phe Gln Gly Leu His Leu Tyr Thr Val Val Val Tyr Asp Phe 370 375 380 Ala Gln Gly Cys Gln Ile Val Asp Leu Ala Asp Leu Thr Gln Leu Val 385 390 395 400 Asp Ser Cys Lys Ser Thr Val Val Trp Met Leu Glu Ala Leu Glu Gly 405 410 415 Leu Ser Gly Gln Glu Leu Thr Asp His Met Gly Met Thr Ala Ser Tyr 420 425 430 Thr Ser Asn Leu Ala Tyr Ser Phe Tyr Ser His Lys Leu Tyr Ala Glu 435 440 445 Ala Cys Ala Ile Ser Glu Pro Leu Cys Gln His Leu Gly Leu Val Lys 450 455 460 Pro Gly Thr Tyr Pro Glu Val Pro Pro Glu Lys Leu His Arg Cys Phe 465 470 475 480 Arg Leu Gln Val Glu Ser Leu Lys Lys Leu Gly Lys Gln Ala Gln Gly 485 490 495 Cys Lys Met Val Ile Leu Trp Leu Ala Ala Leu Gln Pro Cys Ser Pro 500 505 510 Glu His Met Ala Glu Pro Val Thr Phe Trp Val Arg Val Lys Met Asp 515 520 525 Ala Ala Arg Ala Gly Asp Lys Glu Leu Gln Leu Lys Thr Leu Arg Asp 530 535 540 Ser Leu Ser Gly Trp Asp Pro Glu Thr Leu Ala Leu Leu Leu Arg Glu 545 550 555 560 Glu Leu Gln Ala Tyr Lys Ala Val Arg Ala Asp Thr Gly Gln Glu Arg 565 570 575 Phe Asn Ile Ile Cys Asp Leu Leu Glu Leu Ser Pro Glu Glu Thr Pro 580 585 590 Ala Gly Ala Trp Ala Arg Ala Thr His Leu Val Glu Leu Ala Gln Val 595 600 605 Leu Cys Tyr His Asp Phe Thr Gln Gln Thr Asn Cys Ser Ala Leu Asp 610 615 620 Ala Ile Arg Glu Ala Leu Gln Leu Leu Asp Ser Val Arg Pro Glu Ala 625 630 635 640 Gln Ala Arg Asp Gln Leu Leu Asp Asp Lys Ala Gln Ala Leu Leu Trp 645 650 655 Leu Tyr Ile Cys Thr Leu Glu Ala Lys Ile Gln Glu Gly Ile Glu Arg 660 665 670 Asp Arg Arg Ala Gln Ala Pro Gly Asn Leu Glu Glu Phe Glu Val Asn 675 680 685 Asp Leu Asn Tyr Glu Asp Lys Leu Gln Glu Asp Arg Phe Leu Tyr Ser 690 695 700 Asn Ile Ala Phe Asn Leu Ala Ala Asp Ala Ala Gln Ser Lys Cys Leu 705 710 715 720 Asp Gln Ala Leu Ala Leu Trp Lys Glu Leu Leu Thr Lys Gly Gln Ala 725 730 735 Pro Ala Val Arg Cys Leu Gln Gln Thr Ala Ala Ser Leu Gln Ile Leu 740 745 750 Ala Ala Leu Tyr Gln Leu Val Ala Lys Pro Met Gln Ala Leu Glu Val 755 760 765 Leu Leu Leu Leu Arg Ile Val Ser Glu Arg Leu Lys Asp His Ser Lys 770 775 780 Ala Ala Gly Ser Ser Cys His Ile Thr Gln Leu Leu Leu Thr Leu Gly 785 790 795 800 Cys Pro Ser Tyr Ala Gln Leu His Leu Glu Glu Ala Ala Ser Ser Leu 805 810 815 Lys His Leu Asp Gln Thr Thr Asp Thr Tyr Leu Leu Leu Ser Leu Thr 820 825 830 Cys Asp Leu Leu Arg Ser Gln Leu Tyr Trp Thr His Gln Lys Val Thr 835 840 845 Lys Gly Val Ser Leu Leu Leu Ser Val Leu Arg Asp Pro Ala Leu Gln 850 855 860 Lys Ser Ser Lys Ala Trp Tyr Leu Leu Arg Val Gln Val Leu Gln Leu 865 870 875 880 Val Ala Ala Tyr Leu Ser Leu Pro Ser Asn Asn Leu Ser His Ser Leu 885 890 895 Trp Glu Gln Leu Cys Ala Gln Gly Trp Gln Thr Pro Glu Ile Ala Leu 900 905 910 Ile Asp Ser His Lys Leu Leu Arg Ser Ile Ile Leu Leu Leu Met Gly 915 920 925 Ser Asp Ile Leu Ser Thr Gln Lys Ala Ala Val Glu Thr Ser Phe Leu 930 935 940 Asp Tyr Gly Glu Asn Leu Val Gln Lys Trp Gln Val Leu Ser Glu Val 945 950 955 960 Leu Ser Cys Ser Glu Lys Leu Val Cys His Leu Gly Arg Leu Gly Ser 965 970 975 Val Ser Glu Ala Lys Ala Phe Cys Leu Glu Ala Leu Lys Leu Thr Thr 980 985 990 Lys Leu Gln Ile Pro Arg Gln Cys Ala Leu Phe Leu Val Leu Lys Gly 995 1000 1005 Glu Leu Glu Leu Ala Arg Asn Asp Ile Asp Leu Cys Gln Ser Asp 1010 1015 1020 Leu Gln Gln Val Leu Phe Leu Leu Glu Ser Cys Thr Glu Phe Gly 1025 1030 1035 Gly Val Thr Gln His Leu Asp Ser Val Lys Lys Val His Leu Gln 1040 1045 1050 Lys Gly Lys Gln Gln Ala Gln Val Pro Cys Pro Pro Gln Leu Pro 1055 1060 1065 Glu Glu Glu Leu Phe Leu Arg Gly Pro Ala Leu Glu Leu Val Ala 1070 1075 1080 Thr Val Ala Lys Glu Pro Gly Pro Ile Ala Pro Ser Thr Asn Ser 1085 1090 1095 Ser Pro Val Leu Lys Thr Lys Pro Gln Pro Ile Pro Asn Phe Leu 1100 1105 1110 Ser His Ser Pro Thr Cys Asp Cys Ser Leu Cys Ala Ser Pro Val 1115 1120 1125 Leu Thr Ala Val Cys Leu Arg Trp Val Leu Val Thr Ala Gly Val 1130 1135 1140 Arg Leu Ala Met Gly His Gln Ala Gln Gly Leu Asp Leu Leu Gln 1145 1150 1155 Val Val Leu Lys Gly Cys Pro Glu Ala Ala Glu Arg Leu Thr Gln 1160 1165 1170 Ala Leu Gln Ala Ser Leu Asn His Lys Thr Pro Pro Ser Leu Val 1175 1180 1185 Pro Ser Leu Leu Asp Glu Ile Leu Ala Gln Ala Tyr Thr Leu Leu 1190 1195 1200 Ala Leu Glu Gly Leu Asn Gln Pro Ser Asn Glu Ser Leu Gln Lys 1205 1210 1215 Val Leu Gln Ser Gly Leu Lys Phe Val Ala Ala Arg Ile Pro His 1220 1225 1230 Leu Glu Pro Trp Arg Ala Ser Leu Leu Leu Ile Trp Ala Leu Thr 1235 1240 1245 Lys Leu Gly Gly Leu Ser Cys Cys Thr Thr Gln Leu Phe Ala Ser 1250 1255 1260 Ser Trp Gly Trp Gln Pro Pro Leu Ile Lys Ser Val Pro Gly Ser 1265 1270 1275 Glu Pro Ser Lys Thr Gln Gly Gln Lys Arg Ser Gly Arg Gly Arg 1280 1285 1290 Gln Lys Leu Ala Ser Ala Pro Leu Ser Leu Asn Asn Thr Ser Gln 1295 1300 1305 Lys Gly Leu Glu Gly Arg Gly Leu Pro Cys Thr Pro Lys Pro Pro 1310 1315 1320 Asp Arg Ile Arg Gln Ala Gly Pro His Val Pro Phe Thr Val Phe 1325 1330 1335 Glu Glu Val Cys Pro Thr Glu Ser Lys Pro Glu Val Pro Gln Ala 1340 1345 1350 Pro Arg Val Gln Gln Arg Val Gln Thr Arg Leu Lys Val Asn Phe 1355 1360 1365 Ser Asp Asp Ser Asp Leu Glu Asp Pro Val Ser Ala Glu Ala Trp 1370 1375 1380 Leu Ala Glu Glu Pro Lys Arg Arg Gly Thr Ala Ser Arg Gly Arg 1385 1390 1395 Gly Arg Ala Arg Lys Gly Leu Ser Leu Lys Thr Asp Ala Val Val 1400 1405 1410 Ala Pro Gly Ser Ala Pro Gly Asn Pro Gly Leu Asn Gly Arg Ser 1415 1420 1425 Arg Arg Ala Lys Lys Val Ala Ser Arg His Cys Glu Glu Arg Arg 1430 1435 1440 Pro Gln Arg Ala Ser Asp Gln Ala Arg Pro Gly Pro Glu Ile Met 1445 1450 1455 Arg Thr Ile Pro Glu Glu Glu Leu Thr Asp Asn Trp Arg Lys Met 1460 1465 1470 Ser Phe Glu Ile Leu Arg Gly Ser Asp Gly Glu Asp Ser Ala Ser 1475 1480 1485 Gly Gly Lys Thr Pro Ala Pro Gly Pro Glu Ala Ala Ser Gly Glu 1490 1495 1500 Trp Glu Leu Leu Arg Leu Asp Ser Ser Lys Lys Lys Leu Pro Ser 1505 1510 1515 Pro Cys Pro Asp Lys Glu Ser Asp Lys Asp Leu Gly Pro Arg Leu 1520 1525 1530 Gln Leu Pro Ser Ala Pro Val Ala Thr Gly Leu Ser Thr Leu Asp 1535 1540 1545 Ser Ile Cys Asp Ser Leu Ser Val Ala Phe Arg Gly Ile Ser His 1550 1555 1560 Cys Pro Pro Ser Gly Leu Tyr Ala His Leu Cys Arg Phe Leu Ala 1565 1570 1575 Leu Cys Leu Gly His Arg Asp Pro Tyr Ala Thr Ala Phe Leu Val 1580 1585 1590 Thr Glu Ser Val Ser Ile Thr Cys Arg His Gln Leu Leu Thr His 1595 1600 1605 Leu His Arg Gln Leu Ser Lys Ala Gln Lys His Arg Gly Ser Leu 1610 1615 1620 Glu Ile Ala Asp Gln Leu Gln Gly Leu Ser Leu Gln Glu Met Pro 1625 1630 1635 Gly Asp Val Pro Leu Ala Arg Ile Gln Arg Leu Phe Ser Phe Arg 1640 1645 1650 Ala Leu Glu Ser Gly His Phe Pro Gln Pro Glu Lys Glu Ser Phe 1655 1660 1665 Gln Glu Arg Leu Ala Leu Ile Pro Ser Gly Val Thr Val Cys Val 1670 1675 1680 Leu Ala Leu Ala Thr Leu Gln Pro Gly Thr Val Gly Asn Thr Leu 1685 1690 1695 Leu Leu Thr Arg Leu Glu Lys Asp Ser Pro Pro Val Ser Val Gln 1700 1705 1710 Ile Pro Thr Gly Gln Asn Lys Leu His Leu Arg Ser Val Leu Asn 1715 1720 1725 Glu Phe Asp Ala Ile Gln Lys Ala Gln Lys Glu Asn Ser Ser Cys 1730 1735 1740 Thr Asp Lys Arg Glu Trp Trp Thr Gly Arg Leu Ala Leu Asp His 1745 1750 1755 Arg Met Glu Val Leu Ile Ala Ser Leu Glu Lys Ser Val Leu Gly 1760 1765 1770 Cys Trp Lys Gly Leu Leu Leu Pro Ser Ser Glu Glu Pro Gly Pro 1775 1780 1785 Ala Gln Glu Ala Ser Arg Leu Gln Glu Leu Leu Gln Asp Cys Gly 1790 1795 1800 Trp Lys Tyr Pro Asp Arg Thr Leu Leu Lys Ile Met Leu Ser Gly 1805 1810 1815 Ala Gly Ala Leu Thr Pro Gln Asp Ile Gln Ala Leu Ala Tyr Gly 1820 1825 1830 Leu Cys Pro Thr Gln Pro Glu Arg Ala Gln Glu Leu Leu Asn Glu 1835 1840 1845 Ala Val Gly Arg Leu Gln Gly Leu Thr Val Pro Ser Asn Ser His 1850 1855 1860 Leu Val Leu Val Leu Asp Lys Asp Leu Gln Lys Leu Pro Trp Glu 1865 1870 1875 Ser Met Pro Ser Leu Gln Ala Leu Pro Val Thr Arg Leu Pro Ser 1880 1885 1890 Phe Arg Phe Leu Leu Ser Tyr Ser Ile Ile Lys Glu Tyr Gly Ala 1895 1900 1905 Ser Pro Val Leu Ser Gln Gly Val Asp Pro Arg Ser Thr Phe Tyr 1910 1915 1920 Val Leu Asn Pro His Asn Asn Leu Ser Ser Thr Glu Glu Gln Phe 1925 1930 1935 Arg Ala Asn Phe Ser Ser Glu Ala Gly Trp Arg Gly Val Val Gly 1940 1945 1950 Glu Val Pro Arg Pro Glu Gln Val Gln Glu Ala Leu Thr Lys His 1955 1960 1965 Asp Leu Tyr Ile Tyr Ala Gly His Gly Ala Gly Ala Arg Phe Leu 1970 1975 1980 Asp Gly Gln Ala Val Leu Arg Leu Ser Cys Arg Ala Val Ala Leu 1985 1990 1995 Leu Phe Gly Cys Ser Ser Ala Ala Leu Ala Val His Gly Asn Leu 2000 2005 2010 Glu Gly Ala Gly Ile Val Leu Lys Tyr Ile Met Ala Gly Cys Pro 2015 2020 2025 Leu Phe Leu Gly Asn Leu Trp Asp Val Thr Asp Arg Asp Ile Asp 2030 2035 2040 Arg Tyr Thr Glu Ala Leu Leu Gln Gly Trp Leu Gly Ala Gly Pro 2045 2050 2055 Gly Ala Pro Leu Leu Tyr Tyr Val Asn Gln Ala Arg Gln Ala Pro 2060 2065 2070 Arg Leu Lys Tyr Leu Ile Gly Ala Ala Pro Ile Ala Tyr Gly Leu 2075 2080 2085 Pro Val Ser Leu Arg 2090 <210> 932 <211> 298 <212> PRT <213> Homo sapiens <400> 932 Met Val Thr Pro Ala Leu Gln Met Lys Lys Pro Lys Gln Phe Cys Arg 1 5 10 15 Arg Met Gly Gln Lys Lys Gln Arg Pro Ala Arg Ala Gly Gln Pro His 20 25 30 Ser Ser Ser Asp Ala Ala Gln Ala Pro Ala Glu Gln Pro His Ser Ser 35 40 45 Ser Asp Ala Ala Gln Ala Pro Cys Pro Arg Glu Arg Cys Leu Gly Pro 50 55 60 Pro Thr Thr Pro Gly Pro Tyr Arg Ser Ile Tyr Phe Ser Ser Pro Lys 65 70 75 80 Gly His Leu Thr Arg Leu Gly Leu Glu Phe Phe Asp Gln Pro Ala Val 85 90 95 Pro Leu Ala Arg Ala Phe Leu Gly Gln Val Leu Val Arg Arg Leu Pro 100 105 110 Asn Gly Thr Glu Leu Arg Gly Arg Ile Val Glu Thr Glu Ala Tyr Leu 115 120 125 Gly Pro Glu Asp Glu Pro Ala His Ser Arg Gly Gly Arg Gln Thr Pro 130 135 140 Arg Asn Arg Gly Met Phe Met Lys Pro Gly Thr Leu Tyr Val Tyr Ile 145 150 155 160 Ile Tyr Gly Met Tyr Phe Cys Met Asn Ile Ser Ser Gln Gly Asp Gly 165 170 175 Ala Cys Val Leu Leu Arg Ala Leu Glu Pro Leu Glu Gly Leu Glu Thr 180 185 190 Met Arg His Val Arg Ser Thr Leu Arg Lys Gly Thr Ala Ser Arg Val 195 200 205 Leu Lys Asp Arg Glu Leu Cys Ser Gly Pro Ser Lys Leu Cys Gln Ala 210 215 220 Leu Ala Ile Asn Lys Ser Phe Asp Gln Arg Asp Leu Ala Gln Asp Glu 225 230 235 240 Ala Val Trp Leu Glu Arg Gly Pro Leu Glu Pro Ser Glu Pro Ala Val 245 250 255 Val Ala Ala Ala Arg Val Gly Val Gly His Ala Gly Glu Trp Ala Arg 260 265 270 Lys Pro Leu Arg Phe Tyr Val Arg Gly Ser Pro Trp Val Ser Val Val 275 280 285 Asp Arg Val Ala Glu Gln Asp Thr Gln Ala 290 295 <210> 933 <211> 69 <212> PRT <213> Homo sapiens <400> 933 Ser Phe Asp Gln Arg Asp Leu Ala Gln Asp Glu Ala Val Trp Leu Glu 1 5 10 15 Arg Gly Pro Leu Glu Pro Ser Glu Pro Ala Val Val Ala Ala Ala Arg 20 25 30 Val Gly Val Gly His Ala Gly Glu Trp Ala Arg Lys Pro Leu Arg Phe 35 40 45 Tyr Val Arg Gly Ser Pro Trp Val Ser Val Val Asp Arg Val Ala Glu 50 55 60 Gln Asp Thr Gln Ala 65 <210> 934 <211> 298 <212> PRT <213> Homo sapiens <400> 934 Met Val Thr Pro Ala Leu Gln Met Lys Lys Pro Lys Gln Phe Cys Arg 1 5 10 15 Arg Met Gly Gln Lys Lys Gln Arg Pro Ala Arg Ala Gly Gln Pro His 20 25 30 Ser Ser Ser Asp Ala Ala Gln Ala Pro Ala Glu Gln Pro His Ser Ser 35 40 45 Ser Asp Ala Ala Gln Ala Pro Cys Pro Arg Glu Arg Cys Leu Gly Pro 50 55 60 Pro Thr Thr Pro Gly Pro Tyr Arg Ser Ile Tyr Phe Ser Ser Pro Lys 65 70 75 80 Gly His Leu Thr Arg Leu Gly Leu Glu Phe Phe Asp Gln Pro Ala Val 85 90 95 Pro Leu Ala Arg Ala Phe Leu Gly Gln Val Leu Val Arg Arg Leu Pro 100 105 110 Asn Gly Thr Glu Leu Arg Gly Arg Ile Val Glu Thr Glu Ala Tyr Leu 115 120 125 Gly Pro Glu Asp Glu Pro Ala His Ser Arg Gly Gly Arg Gln Thr Pro 130 135 140 Arg Asn Arg Gly Met Phe Met Lys Pro Gly Thr Leu Tyr Val Tyr Ile 145 150 155 160 Ile Tyr Gly Met Tyr Phe Cys Met Asn Ile Ser Ser Gln Gly Asp Gly 165 170 175 Ala Cys Val Leu Leu Arg Ala Leu Glu Pro Leu Glu Gly Leu Glu Thr 180 185 190 Met Arg His Val Arg Ser Thr Leu Arg Lys Gly Thr Ala Ser Arg Val 195 200 205 Leu Lys Asp Arg Glu Leu Cys Ser Gly Pro Ser Lys Leu Cys Gln Ala 210 215 220 Leu Ala Ile Asn Lys Ser Phe Asp Gln Arg Asp Leu Ala Gln Asp Glu 225 230 235 240 Ala Val Trp Leu Glu Arg Gly Pro Leu Glu Pro Ser Glu Pro Ala Val 245 250 255 Val Ala Ala Ala Arg Val Gly Val Gly His Ala Gly Glu Trp Ala Arg 260 265 270 Lys Pro Leu Arg Phe Tyr Val Arg Gly Ser Pro Trp Val Ser Val Val 275 280 285 Asp Arg Val Ala Glu Gln Asp Thr Gln Ala 290 295 <210> 935 <211> 293 <212> PRT <213> Homo sapiens <400> 935 Met Pro Ala Arg Ser Gly Ala Gln Phe Cys Arg Arg Met Gly Gln Lys 1 5 10 15 Lys Gln Arg Pro Ala Arg Ala Gly Gln Pro His Ser Ser Ser Asp Ala 20 25 30 Ala Gln Ala Pro Ala Glu Gln Pro His Ser Ser Ser Asp Ala Ala Gln 35 40 45 Ala Pro Cys Pro Arg Glu Arg Cys Leu Gly Pro Pro Thr Thr Pro Gly 50 55 60 Pro Tyr Arg Ser Ile Tyr Phe Ser Ser Pro Lys Gly His Leu Thr Arg 65 70 75 80 Leu Gly Leu Glu Phe Phe Asp Gln Pro Ala Val Pro Leu Ala Arg Ala 85 90 95 Phe Leu Gly Gln Val Leu Val Arg Arg Leu Pro Asn Gly Thr Glu Leu 100 105 110 Arg Gly Arg Ile Val Glu Thr Glu Ala Tyr Leu Gly Pro Glu Asp Glu 115 120 125 Ala Ala His Ser Arg Gly Gly Arg Gln Thr Pro Arg Asn Arg Gly Met 130 135 140 Phe Met Lys Pro Gly Thr Leu Tyr Val Tyr Ile Ile Tyr Gly Met Tyr 145 150 155 160 Phe Cys Met Asn Ile Ser Ser Gln Gly Asp Gly Ala Cys Val Leu Leu 165 170 175 Arg Ala Leu Glu Pro Leu Glu Gly Leu Glu Thr Met Arg His Val Arg 180 185 190 Ser Thr Leu Arg Lys Gly Thr Ala Ser Arg Val Leu Lys Asp Arg Glu 195 200 205 Leu Cys Ser Gly Pro Ser Lys Leu Cys Gln Ala Leu Ala Ile Asn Lys 210 215 220 Ser Phe Asp Gln Arg Asp Leu Ala Gln Asp Glu Ala Val Trp Leu Glu 225 230 235 240 Arg Gly Pro Leu Glu Pro Ser Glu Pro Ala Val Val Ala Ala Ala Arg 245 250 255 Val Gly Val Gly His Ala Gly Glu Trp Ala Arg Lys Pro Leu Arg Phe 260 265 270 Tyr Val Arg Gly Ser Pro Trp Val Ser Val Val Asp Arg Val Ala Glu 275 280 285 Gln Asp Thr Gln Ala 290 <210> 936 <211> 298 <212> PRT <213> Homo sapiens <400> 936 Met Val Thr Pro Ala Leu Gln Met Lys Lys Pro Lys Gln Phe Cys Arg 1 5 10 15 Arg Met Gly Gln Lys Lys Gln Arg Pro Ala Arg Ala Gly Gln Pro His 20 25 30 Ser Ser Ser Asp Ala Ala Gln Ala Pro Ala Glu Gln Pro His Ser Ser 35 40 45 Ser Asp Ala Ala Gln Ala Pro Cys Pro Arg Glu Arg Cys Leu Gly Pro 50 55 60 Pro Thr Thr Pro Gly Pro Tyr Arg Ser Ile Tyr Phe Ser Ser Pro Lys 65 70 75 80 Gly His Leu Thr Arg Leu Gly Leu Glu Phe Phe Asp Gln Pro Ala Val 85 90 95 Pro Leu Ala Arg Ala Phe Leu Gly Gln Val Leu Val Arg Arg Leu Pro 100 105 110 Asn Gly Thr Glu Leu Arg Gly Arg Ile Val Glu Thr Glu Ala Tyr Leu 115 120 125 Gly Pro Glu Asp Glu Pro Ala His Ser Arg Gly Gly Arg Gln Thr Pro 130 135 140 Arg Asn Arg Gly Met Phe Met Lys Pro Gly Thr Leu Tyr Val Tyr Ile 145 150 155 160 Ile Tyr Gly Met Tyr Phe Cys Met Asn Ile Ser Ser Gln Gly Asp Gly 165 170 175 Ala Cys Val Leu Leu Arg Ala Leu Glu Pro Leu Glu Gly Leu Glu Thr 180 185 190 Met Arg His Val Arg Ser Thr Leu Arg Lys Gly Thr Ala Ser Arg Val 195 200 205 Leu Lys Asp Arg Glu Leu Cys Ser Gly Pro Ser Lys Leu Cys Gln Ala 210 215 220 Leu Ala Ile Asn Lys Ser Phe Asp Gln Arg Asp Leu Ala Gln Asp Glu 225 230 235 240 Ala Val Trp Leu Glu Arg Gly Pro Leu Glu Pro Ser Glu Pro Ala Val 245 250 255 Val Ala Ala Ala Arg Val Gly Val Gly His Ala Gly Glu Trp Ala Arg 260 265 270 Lys Pro Leu Arg Phe Tyr Val Arg Gly Ser Pro Trp Val Ser Val Val 275 280 285 Asp Arg Val Ala Glu Gln Asp Thr Gln Ala 290 295 <210> 937 <211> 230 <212> PRT <213> Homo sapiens <400> 937 Ser Lys Asp Arg Ser Ile Tyr Phe Ser Ser Pro Lys Gly Leu Leu Thr 1 5 10 15 Arg Leu Gly Leu Glu Phe Phe Asp Gln Pro Ala Val Pro Leu Ala Arg 20 25 30 Ala Phe Leu Gly Gln Val Leu Val Arg Arg Leu Pro Asn Gly Thr Glu 35 40 45 Leu Arg Gly Arg Ile Val Glu Thr Glu Ala Tyr Leu Gly Pro Glu Asp 50 55 60 Glu Ala Ala His Ser Arg Gly Gly Arg Gln Thr Pro Arg Asn Arg Gly 65 70 75 80 Met Phe Met Lys Pro Gly Thr Leu Tyr Val Tyr Ile Ile Tyr Gly Met 85 90 95 Tyr Phe Cys Met Asn Ile Ser Ser Gln Gly Asp Gly Ala Cys Val Leu 100 105 110 Leu Arg Ala Leu Glu Pro Leu Glu Gly Leu Glu Thr Met Arg His Val 115 120 125 Arg Ser Thr Leu Arg Lys Gly Thr Ala Ser Arg Val Leu Lys Asp Arg 130 135 140 Glu Leu Cys Ser Gly Pro Ser Lys Leu Cys Gln Ala Leu Ala Ile Asn 145 150 155 160 Lys Ser Phe Asp Gln Arg Asp Leu Ala Gln Asp Glu Ala Val Trp Leu 165 170 175 Glu Arg Gly Pro Leu Glu Pro Ser Glu Pro Ala Val Val Ala Ala Ala 180 185 190 Arg Val Gly Val Gly His Ala Gly Glu Trp Ala Arg Lys Pro Leu Arg 195 200 205 Phe Tyr Val Arg Gly Ser Pro Trp Val Ser Val Val Asp Arg Val Ala 210 215 220 Glu Gln Asp Thr Gln Ala 225 230 <210> 938 <211> 293 <212> PRT <213> Homo sapiens <400> 938 Met Pro Ala Arg Ser Gly Ala Gln Phe Cys Arg Arg Met Gly Gln Lys 1 5 10 15 Lys Gln Arg Pro Ala Arg Ala Gly Gln Pro His Ser Ser Ser Asp Ala 20 25 30 Ala Gln Ala Pro Ala Glu Gln Pro His Ser Ser Ser Asp Ala Ala Gln 35 40 45 Ala Pro Cys Pro Arg Glu Arg Cys Leu Gly Pro Pro Thr Thr Pro Gly 50 55 60 Pro Tyr Arg Ser Ile Tyr Phe Ser Ser Pro Lys Gly His Leu Thr Arg 65 70 75 80 Leu Gly Leu Glu Phe Phe Asp Gln Pro Ala Val Pro Leu Ala Arg Ala 85 90 95 Phe Leu Gly Gln Val Leu Val Arg Arg Leu Pro Asn Gly Thr Glu Leu 100 105 110 Arg Gly Arg Ile Val Glu Thr Glu Ala Tyr Leu Gly Pro Glu Asp Glu 115 120 125 Ala Ala His Ser Arg Gly Gly Arg Gln Thr Pro Arg Asn Arg Gly Met 130 135 140 Phe Met Lys Pro Gly Thr Leu Tyr Val Tyr Ile Ile Tyr Gly Met Tyr 145 150 155 160 Phe Cys Met Asn Ile Ser Ser Gln Gly Asp Gly Ala Cys Val Leu Leu 165 170 175 Arg Ala Leu Glu Pro Leu Glu Gly Leu Glu Thr Met Arg Gln Leu Arg 180 185 190 Ser Thr Leu Arg Lys Gly Thr Ala Ser Arg Val Leu Lys Asp Arg Glu 195 200 205 Leu Cys Ser Gly Pro Ser Lys Leu Cys Gln Ala Leu Ala Ile Asn Lys 210 215 220 Ser Phe Asp Gln Arg Asp Leu Ala Gln Asp Glu Ala Val Trp Leu Glu 225 230 235 240 Arg Gly Pro Leu Glu Pro Ser Glu Pro Ala Val Val Ala Ala Ala Arg 245 250 255 Val Gly Val Gly His Ala Gly Glu Trp Ala Arg Lys Pro Leu Arg Phe 260 265 270 Tyr Val Arg Gly Ser Pro Trp Val Ser Val Val Asp Arg Val Ala Glu 275 280 285 Gln Asp Thr Gln Ala 290 <210> 939 <211> 230 <212> PRT <213> Homo sapiens <400> 939 Ser Lys Asp Arg Ser Ile Tyr Phe Ser Ser Pro Lys Gly Leu Leu Thr 1 5 10 15 Arg Leu Gly Leu Glu Phe Phe Asp Gln Pro Ala Val Pro Leu Ala Arg 20 25 30 Ala Phe Leu Gly Gln Val Leu Val Arg Arg Leu Pro Asn Gly Thr Glu 35 40 45 Leu Arg Gly Arg Ile Val Glu Thr Glu Ala Tyr Leu Gly Pro Glu Asp 50 55 60 Glu Ala Ala His Ser Arg Gly Gly Arg Gln Thr Pro Arg Asn Arg Gly 65 70 75 80 Met Phe Met Lys Pro Gly Thr Leu Tyr Val Tyr Ile Ile Tyr Gly Met 85 90 95 Tyr Phe Cys Met Asn Ile Ser Ser Gln Gly Asp Gly Ala Cys Val Leu 100 105 110 Leu Arg Ala Leu Glu Pro Leu Glu Gly Leu Glu Thr Met Arg His Val 115 120 125 Arg Ser Thr Leu Arg Lys Gly Thr Ala Ser Arg Val Leu Lys Asp Arg 130 135 140 Glu Leu Cys Ser Gly Pro Ser Lys Leu Cys Gln Ala Leu Ala Ile Asn 145 150 155 160 Lys Ser Phe Asp Gln Arg Asp Leu Ala Gln Asp Glu Ala Val Trp Leu 165 170 175 Glu Arg Gly Pro Leu Glu Pro Ser Glu Pro Ala Val Val Ala Ala Ala 180 185 190 Arg Val Gly Val Gly His Ala Gly Glu Trp Ala Arg Lys Pro Leu Arg 195 200 205 Phe Tyr Val Arg Gly Ser Pro Trp Val Ser Glu Val Asp Arg Val Ala 210 215 220 Glu Gln Asp Thr Gln Ala 225 230 <210> 940 <211> 271 <212> PRT <213> Homo sapiens <400> 940 Ala Ala Arg Ala His Ser Ser Ser Asp Ala Ala Gln Ala Pro Ala Glu 1 5 10 15 Arg Pro His Ser Ser Ser Asp Ala Ala Gln Ala Pro Cys Pro Arg Glu 20 25 30 Arg Cys Leu Gly Pro Pro Thr Thr Pro Gly Pro Tyr Arg Ser Ile Tyr 35 40 45 Phe Ser Ser Pro Lys Gly His Leu Thr Arg Leu Gly Leu Glu Phe Phe 50 55 60 Asp Gln Pro Ala Val Pro Leu Ala Arg Ala Phe Leu Gly Gln Val Leu 65 70 75 80 Val Arg Arg Leu Pro Asn Gly Thr Glu Leu Arg Gly Arg Ile Val Glu 85 90 95 Thr Glu Ala Tyr Leu Gly Pro Glu Asp Glu Ala Ala His Ser Arg Gly 100 105 110 Gly Arg Gln Thr Pro Arg Asn Arg Gly Met Phe Met Lys Pro Gly Thr 115 120 125 Leu Tyr Val Tyr Ile Ile Tyr Gly Met Tyr Phe Cys Met Asn Ile Ser 130 135 140 Ser Gln Gly Asp Gly Ala Cys Val Leu Leu Arg Ala Leu Glu Pro Leu 145 150 155 160 Glu Gly Leu Glu Thr Met Arg His Val Arg Ser Thr Leu Arg Lys Gly 165 170 175 Thr Ala Ser Arg Val Leu Lys Asp Arg Glu Leu Cys Ser Gly Pro Ser 180 185 190 Lys Leu Cys Gln Ala Leu Ala Ile Asn Lys Ser Phe Asp Gln Arg Asp 195 200 205 Leu Ala Gln Asp Glu Ala Val Trp Leu Glu Arg Gly Pro Leu Glu Pro 210 215 220 Ser Glu Pro Ala Val Val Ala Ala Ala Arg Val Gly Val Gly His Ala 225 230 235 240 Gly Glu Trp Ala Arg Lys Pro Leu Arg Phe Tyr Val Arg Gly Ser Pro 245 250 255 Trp Val Ser Val Val Asp Arg Val Ala Glu Gln Asp Thr Gln Ala 260 265 270 <210> 941 <211> 575 <212> PRT <213> Homo sapiens <400> 941 Met Asp Pro Arg Gly Ile Leu Lys Ala Phe Pro Lys Arg Gln Lys Ile 1 5 10 15 His Ala Asp Ala Ser Ser Lys Val Leu Ala Lys Ile Pro Arg Arg Glu 20 25 30 Glu Gly Glu Glu Ala Glu Glu Trp Leu Ser Ser Leu Arg Ala His Val 35 40 45 Val Arg Thr Gly Ile Gly Arg Ala Arg Ala Glu Leu Phe Glu Lys Gln 50 55 60 Ile Val Gln His Gly Gly Gln Leu Cys Pro Ala Gln Gly Pro Gly Val 65 70 75 80 Thr His Ile Val Val Asp Glu Gly Met Asp Tyr Glu Arg Ala Leu Arg 85 90 95 Leu Leu Arg Leu Pro Gln Leu Pro Pro Gly Ala Gln Leu Val Lys Ser 100 105 110 Ala Trp Leu Ser Leu Cys Leu Gln Glu Arg Arg Leu Val Asp Val Ala 115 120 125 Gly Phe Ser Ile Phe Ile Pro Ser Arg Tyr Leu Asp His Pro Gln Pro 130 135 140 Ser Lys Ala Glu Gln Asp Ala Ser Ile Pro Pro Gly Thr His Glu Ala 145 150 155 160 Leu Leu Gln Thr Ala Leu Ser Pro Pro Pro Pro Pro Thr Arg Pro Val 165 170 175 Ser Pro Pro Gln Lys Ala Lys Glu Ala Pro Asn Thr Gln Ala Gln Pro 180 185 190 Ile Ser Asp Asp Glu Ala Ser Asp Gly Glu Glu Thr Gln Val Ser Ala 195 200 205 Ala Asp Leu Glu Ala Leu Ile Ser Gly His Tyr Pro Thr Ser Leu Glu 210 215 220 Gly Asp Cys Glu Pro Ser Pro Ala Pro Ala Val Leu Asp Lys Trp Val 225 230 235 240 Cys Ala Gln Pro Ser Ser Gln Lys Ala Thr Asn His Asn Leu His Ile 245 250 255 Thr Glu Lys Leu Glu Val Leu Ala Lys Ala Tyr Ser Val Gln Gly Asp 260 265 270 Lys Trp Arg Ala Leu Gly Tyr Ala Lys Ala Ile Asn Ala Leu Lys Ser 275 280 285 Phe His Lys Pro Val Thr Ser Tyr Gln Glu Ala Cys Ser Ile Pro Gly 290 295 300 Ile Gly Lys Arg Met Ala Glu Lys Ile Ile Glu Ile Leu Glu Ser Gly 305 310 315 320 His Leu Arg Lys Leu Asp His Ile Ser Glu Ser Val Pro Val Leu Glu 325 330 335 Leu Phe Ser Asn Ile Trp Gly Ala Gly Thr Lys Thr Ala Gln Met Trp 340 345 350 Tyr Gln Gln Gly Phe Arg Ser Leu Glu Asp Ile Arg Ser Gln Ala Ser 355 360 365 Leu Thr Thr Gln Gln Ala Ile Gly Leu Lys His Tyr Ser Asp Phe Leu 370 375 380 Glu Arg Met Pro Arg Glu Glu Ala Thr Glu Ile Glu Gln Thr Val Gln 385 390 395 400 Lys Ala Ala Gln Ala Phe Asn Ser Gly Leu Leu Cys Val Ala Cys Gly 405 410 415 Ser Tyr Arg Arg Gly Lys Ala Thr Cys Gly Asp Val Asp Val Leu Ile 420 425 430 Thr His Pro Asp Gly Arg Ser His Arg Gly Ile Phe Ser Arg Leu Leu 435 440 445 Asp Ser Leu Arg Gln Glu Gly Phe Leu Thr Asp Asp Leu Val Ser Gln 450 455 460 Glu Glu Asn Gly Gln Gln Gln Lys Tyr Leu Gly Val Cys Arg Leu Pro 465 470 475 480 Gly Pro Gly Arg Arg His Arg Arg Leu Asp Ile Ile Val Val Pro Tyr 485 490 495 Ser Glu Phe Ala Cys Ala Leu Leu Tyr Phe Thr Gly Ser Ala His Phe 500 505 510 Asn Arg Ser Met Arg Ala Leu Ala Lys Thr Lys Gly Met Ser Leu Ser 515 520 525 Glu His Ala Leu Ser Thr Ala Val Val Arg Asn Thr His Gly Cys Lys 530 535 540 Val Gly Pro Gly Arg Val Leu Pro Thr Pro Thr Glu Lys Asp Val Phe 545 550 555 560 Arg Leu Leu Gly Leu Pro Tyr Arg Glu Pro Ala Glu Arg Asp Trp 565 570 575 <210> 942 <211> 267 <212> PRT <213> Homo sapiens <400> 942 Met Ala Glu Lys Ile Ile Glu Ile Leu Glu Ser Gly His Leu Arg Lys 1 5 10 15 Leu Asp His Ile Ser Glu Ser Val Pro Val Leu Glu Leu Phe Ser Asn 20 25 30 Ile Trp Gly Ala Gly Thr Lys Thr Ala Gln Met Trp Tyr Gln Gln Gly 35 40 45 Phe Arg Ser Leu Glu Asp Ile Arg Ser Gln Ala Ser Leu Thr Thr Gln 50 55 60 Gln Ala Ile Gly Leu Lys His Tyr Ser Asp Phe Leu Glu Arg Met Pro 65 70 75 80 Arg Glu Glu Ala Thr Glu Ile Glu Gln Thr Val Gln Lys Ala Ala Gln 85 90 95 Ala Phe Asn Ser Gly Leu Leu Cys Val Ala Cys Gly Ser Tyr Arg Arg 100 105 110 Gly Lys Ala Thr Cys Gly Asp Val Asp Val Leu Ile Thr His Pro Asp 115 120 125 Gly Trp Ser His Arg Gly Ile Phe Ser Arg Leu Leu Asp Ser Leu Arg 130 135 140 Gln Glu Gly Phe Leu Thr Asp Asp Leu Val Ser Gln Glu Glu Asn Gly 145 150 155 160 Gln Gln Gln Lys Tyr Leu Gly Val Cys Arg Leu Pro Gly Pro Gly Arg 165 170 175 Arg His Arg Arg Leu Asp Ile Ile Val Val Pro Tyr Ser Glu Phe Ala 180 185 190 Cys Ala Leu Leu Tyr Phe Thr Gly Ser Ala His Phe Asn Arg Ser Met 195 200 205 Arg Ala Leu Ala Lys Thr Lys Gly Met Ser Leu Ser Glu His Ala Leu 210 215 220 Ser Thr Ala Val Val Arg Asn Thr His Gly Cys Lys Val Gly Pro Gly 225 230 235 240 Arg Val Leu Pro Thr Pro Thr Glu Lys Asp Val Phe Arg Leu Leu Gly 245 250 255 Leu Pro Tyr Arg Glu Pro Ala Glu Arg Asp Trp 260 265 <210> 943 <211> 575 <212> PRT <213> Homo sapiens <400> 943 Met Asp Pro Arg Gly Ile Leu Lys Ala Phe Pro Lys Arg Gln Lys Ile 1 5 10 15 His Ala Asp Ala Ser Ser Lys Val Leu Ala Lys Ile Pro Arg Arg Glu 20 25 30 Glu Gly Glu Glu Ala Glu Glu Trp Leu Ser Ser Leu Arg Ala His Val 35 40 45 Val Arg Thr Gly Ile Gly Arg Ala Arg Ala Glu Leu Phe Glu Lys Gln 50 55 60 Ile Val Gln His Gly Gly Gln Leu Cys Pro Ala Gln Gly Pro Gly Val 65 70 75 80 Thr His Ile Val Val Asp Glu Gly Met Asp Tyr Glu Arg Ala Leu Arg 85 90 95 Leu Leu Arg Leu Pro Gln Leu Pro Pro Gly Ala Gln Leu Val Lys Ser 100 105 110 Ala Trp Leu Ser Leu Cys Leu Gln Glu Arg Arg Leu Val Asp Val Ala 115 120 125 Gly Phe Ser Ile Phe Ile Pro Ser Arg Tyr Leu Asp His Pro Gln Pro 130 135 140 Ser Lys Ala Glu Gln Asp Ala Ser Ile Pro Pro Gly Thr His Glu Ala 145 150 155 160 Leu Leu Gln Thr Ala Leu Ser Pro Pro Pro Pro Pro Thr Arg Pro Val 165 170 175 Ser Pro Pro Gln Lys Ala Lys Glu Ala Pro Asn Thr Gln Ala Gln Pro 180 185 190 Ile Ser Asp Asp Glu Ala Ser Asp Gly Glu Glu Thr Gln Val Ser Ala 195 200 205 Ala Asp Leu Glu Ala Leu Ile Ser Gly His Tyr Pro Thr Ser Leu Glu 210 215 220 Gly Asp Cys Glu Pro Ser Pro Ala Pro Ala Val Leu Asp Lys Trp Val 225 230 235 240 Cys Ala Gln Pro Ser Ser Gln Lys Ala Thr Asn His Asn Leu His Ile 245 250 255 Thr Glu Lys Leu Glu Val Leu Ala Lys Ala Tyr Ser Val Gln Gly Asp 260 265 270 Lys Trp Arg Ala Leu Gly Tyr Ala Lys Ala Ile Asn Ala Leu Lys Ser 275 280 285 Phe His Lys Pro Val Thr Ser Tyr Gln Gly Ala Cys Ser Ile Pro Gly 290 295 300 Ile Gly Lys Arg Met Ala Glu Lys Ile Ile Glu Ile Leu Glu Ser Gly 305 310 315 320 His Leu Arg Lys Leu Asp His Ile Ser Glu Ser Val Pro Val Leu Glu 325 330 335 Leu Phe Ser Asn Ile Trp Gly Ala Gly Thr Lys Thr Ala Gln Met Trp 340 345 350 Tyr Gln Gln Gly Phe Arg Ser Leu Glu Asp Ile Arg Ser Gln Ala Ser 355 360 365 Leu Thr Thr Gln Gln Ala Ile Gly Leu Lys His Tyr Ser Asp Phe Leu 370 375 380 Glu Arg Met Pro Arg Glu Glu Ala Thr Glu Ile Glu Gln Thr Val Gln 385 390 395 400 Lys Ala Ala Gln Ala Phe Asn Ser Gly Leu Leu Cys Val Ala Cys Gly 405 410 415 Ser Tyr Arg Arg Gly Lys Ala Thr Cys Gly Asp Val Asp Val Leu Ile 420 425 430 Thr His Pro Asp Gly Arg Ser His Arg Gly Ile Phe Ser Arg Leu Leu 435 440 445 Asp Ser Leu Arg Gln Glu Gly Phe Leu Thr Asp Asp Leu Val Ser Gln 450 455 460 Glu Glu Asn Gly Gln Gln Gln Lys Tyr Leu Gly Val Cys Arg Leu Pro 465 470 475 480 Gly Pro Gly Arg Arg His Arg Arg Leu Asp Ile Ile Val Val Pro Tyr 485 490 495 Ser Glu Phe Ala Cys Ala Leu Leu Tyr Phe Thr Gly Ser Ala His Phe 500 505 510 Asn Arg Ser Met Arg Ala Leu Ala Lys Thr Lys Gly Met Ser Leu Ser 515 520 525 Glu His Ala Leu Ser Thr Ala Val Val Arg Asn Thr His Gly Cys Lys 530 535 540 Val Gly Pro Gly Arg Val Leu Pro Thr Pro Thr Glu Lys Asp Val Phe 545 550 555 560 Arg Leu Leu Gly Leu Pro Tyr Arg Glu Pro Ala Glu Arg Asp Trp 565 570 575 <210> 944 <211> 575 <212> PRT <213> Homo sapiens <400> 944 Met Asp Pro Arg Gly Ile Leu Lys Ala Phe Pro Lys Arg Gln Lys Ile 1 5 10 15 His Ala Asp Ala Ser Ser Lys Val Leu Ala Lys Ile Pro Arg Arg Glu 20 25 30 Glu Gly Glu Glu Ala Glu Glu Trp Leu Ser Ser Leu Arg Ala His Val 35 40 45 Val Arg Thr Gly Ile Gly Arg Ala Arg Ala Glu Leu Phe Glu Lys Gln 50 55 60 Ile Val Gln His Gly Gly Gln Leu Cys Pro Ala Gln Gly Pro Gly Val 65 70 75 80 Thr His Ile Val Val Asp Glu Gly Met Asp Tyr Glu Arg Ala Leu Arg 85 90 95 Leu Leu Arg Leu Pro Gln Leu Pro Pro Gly Ala Gln Leu Val Lys Ser 100 105 110 Ala Trp Leu Ser Leu Cys Leu Gln Glu Arg Arg Leu Val Asp Val Ala 115 120 125 Gly Phe Ser Ile Phe Ile Pro Ser Arg Tyr Leu Asp His Pro Gln Pro 130 135 140 Ser Lys Ala Glu Gln Asp Ala Ser Ile Pro Pro Gly Thr His Glu Ala 145 150 155 160 Leu Leu Gln Thr Ala Leu Ser Pro Pro Pro Pro Pro Thr Arg Pro Val 165 170 175 Ser Pro Pro Gln Lys Ala Lys Glu Ala Pro Asn Thr Gln Ala Gln Pro 180 185 190 Ile Ser Asp Asp Glu Ala Ser Asp Gly Glu Glu Thr Gln Val Ser Ala 195 200 205 Ala Asp Leu Glu Ala Leu Ile Ser Gly His Tyr Pro Thr Ser Leu Glu 210 215 220 Gly Asp Cys Glu Pro Ser Pro Ala Pro Ala Val Leu Asp Lys Trp Val 225 230 235 240 Cys Ala Gln Pro Ser Ser Gln Lys Ala Thr Asn His Asn Leu His Ile 245 250 255 Thr Glu Lys Leu Glu Val Leu Ala Lys Ala Tyr Ser Val Gln Gly Asp 260 265 270 Lys Trp Arg Ala Leu Gly Tyr Ala Lys Ala Ile Asn Ala Leu Lys Ser 275 280 285 Phe His Lys Pro Val Thr Ser Tyr Gln Glu Ala Cys Ser Ile Pro Gly 290 295 300 Ile Gly Lys Arg Met Ala Glu Lys Ile Ile Glu Ile Leu Glu Ser Gly 305 310 315 320 His Leu Arg Lys Leu Asp His Ile Ser Glu Ser Val Pro Val Leu Glu 325 330 335 Leu Phe Ser Asn Ile Trp Gly Ala Gly Thr Lys Thr Ala Gln Met Trp 340 345 350 Tyr Gln Gln Gly Phe Arg Ser Leu Glu Asp Ile Arg Ser Gln Ala Ser 355 360 365 Leu Thr Thr Gln Gln Ala Ile Gly Leu Lys His Tyr Ser Asp Phe Leu 370 375 380 Glu Arg Met Pro Arg Glu Glu Ala Thr Glu Ile Glu Gln Thr Val Gln 385 390 395 400 Lys Ala Ala Gln Ala Phe Asn Ser Gly Leu Leu Cys Val Ala Cys Gly 405 410 415 Ser Tyr Arg Arg Gly Lys Ala Thr Cys Gly Asp Val Asp Val Leu Ile 420 425 430 Thr His Pro Asp Gly Arg Ser His Arg Gly Ile Phe Ser Arg Leu Leu 435 440 445 Asp Ser Leu Arg Gln Glu Gly Phe Leu Thr Asp Asp Leu Val Ser Gln 450 455 460 Glu Glu Asn Gly Gln Gln Gln Lys Tyr Leu Gly Val Cys Arg Leu Pro 465 470 475 480 Gly Pro Gly Arg Arg His Arg Arg Leu Asp Ile Ile Val Val Pro Tyr 485 490 495 Ser Glu Phe Ala Cys Ala Leu Leu Tyr Phe Thr Gly Ser Ala His Phe 500 505 510 Asn Arg Ser Met Arg Ala Leu Ala Lys Thr Lys Gly Met Ser Leu Ser 515 520 525 Glu His Ala Leu Ser Thr Ala Val Val Arg Asn Thr His Gly Cys Lys 530 535 540 Val Gly Pro Gly Arg Val Leu Pro Thr Pro Thr Glu Lys Asp Val Phe 545 550 555 560 Arg Leu Leu Gly Leu Pro Tyr Arg Glu Pro Ala Glu Arg Asp Trp 565 570 575 <210> 945 <211> 575 <212> PRT <213> Homo sapiens <400> 945 Met Asp Pro Arg Gly Ile Leu Lys Ala Phe Pro Lys Arg Gln Lys Ile 1 5 10 15 His Ala Asp Ala Ser Ser Lys Val Leu Ala Lys Ile Pro Arg Arg Glu 20 25 30 Glu Gly Glu Glu Ala Glu Glu Trp Leu Ser Ser Leu Arg Ala His Val 35 40 45 Val Arg Thr Gly Ile Gly Arg Ala Arg Ala Glu Leu Phe Glu Lys Gln 50 55 60 Ile Val Gln His Gly Gly Gln Leu Cys Pro Ala Gln Gly Pro Gly Val 65 70 75 80 Thr His Ile Val Val Asp Glu Gly Met Asp Tyr Glu Arg Ala Leu Arg 85 90 95 Leu Leu Arg Leu Pro Gln Leu Pro Pro Gly Ala Gln Leu Val Lys Ser 100 105 110 Ala Trp Leu Ser Leu Cys Leu Gln Glu Arg Arg Leu Val Asp Val Ala 115 120 125 Gly Phe Ser Ile Phe Ile Pro Ser Arg Tyr Leu Asp His Pro Gln Pro 130 135 140 Ser Lys Ala Glu Gln Asp Ala Ser Ile Pro Pro Gly Thr His Glu Ala 145 150 155 160 Leu Leu Gln Thr Ala Leu Ser Pro Pro Pro Pro Pro Thr Arg Pro Val 165 170 175 Ser Pro Pro Gln Lys Ala Lys Glu Ala Pro Asn Thr Gln Ala Gln Pro 180 185 190 Ile Ser Asp Asp Glu Ala Ser Asp Gly Glu Glu Thr Gln Val Ser Ala 195 200 205 Ala Asp Leu Glu Ala Leu Ile Ser Gly His Tyr Pro Thr Ser Leu Glu 210 215 220 Gly Asp Cys Glu Pro Ser Pro Ala Pro Ala Val Leu Asp Lys Trp Val 225 230 235 240 Cys Ala Gln Pro Ser Ser Gln Lys Ala Thr Asn His Asn Leu His Ile 245 250 255 Thr Glu Lys Leu Glu Val Leu Ala Lys Ala Tyr Ser Val Gln Gly Asp 260 265 270 Lys Trp Arg Ala Leu Gly Tyr Ala Lys Ala Ile Asn Ala Leu Lys Ser 275 280 285 Phe His Lys Pro Val Thr Ser Tyr Gln Glu Ala Cys Ser Ile Pro Gly 290 295 300 Ile Gly Lys Arg Met Ala Glu Lys Ile Ile Glu Ile Leu Glu Ser Gly 305 310 315 320 His Leu Arg Lys Leu Asp His Ile Ser Glu Ser Val Pro Val Leu Glu 325 330 335 Leu Phe Ser Asn Ile Trp Gly Ala Gly Thr Lys Thr Ala Gln Met Trp 340 345 350 Tyr Gln Gln Gly Phe Arg Ser Leu Glu Asp Ile Arg Ser Gln Ala Ser 355 360 365 Leu Thr Thr Gln Gln Ala Ile Gly Leu Lys His Tyr Ser Asp Phe Leu 370 375 380 Glu Arg Met Pro Arg Glu Glu Ala Thr Glu Ile Glu Gln Thr Val Gln 385 390 395 400 Lys Ala Ala Gln Ala Phe Asn Ser Gly Leu Leu Cys Val Ala Cys Gly 405 410 415 Ser Tyr Arg Arg Gly Lys Ala Thr Cys Gly Asp Val Asp Val Leu Ile 420 425 430 Thr His Pro Asp Gly Arg Ser His Arg Gly Ile Phe Ser Arg Leu Leu 435 440 445 Asp Ser Leu Arg Gln Glu Gly Phe Leu Thr Asp Asp Leu Val Ser Gln 450 455 460 Glu Glu Asn Gly Gln Gln Gln Lys Tyr Leu Gly Val Cys Arg Leu Pro 465 470 475 480 Gly Pro Gly Arg Arg His Arg Arg Leu Asp Ile Ile Val Val Pro Tyr 485 490 495 Ser Glu Phe Ala Cys Ala Leu Leu Tyr Phe Thr Gly Ser Ala His Phe 500 505 510 Asn Arg Ser Met Arg Ala Leu Ala Lys Thr Lys Gly Met Ser Leu Ser 515 520 525 Glu His Ala Leu Ser Thr Ala Val Val Arg Asn Thr His Gly Cys Lys 530 535 540 Val Gly Pro Gly Arg Val Leu Pro Thr Pro Thr Glu Lys Asp Val Phe 545 550 555 560 Arg Leu Leu Gly Leu Pro Tyr Arg Glu Pro Ala Glu Arg Asp Trp 565 570 575 <210> 946 <211> 575 <212> PRT <213> Homo sapiens <400> 946 Met Asp Pro Arg Gly Ile Leu Lys Ala Phe Pro Lys Arg Gln Lys Ile 1 5 10 15 His Ala Asp Ala Ser Ser Lys Val Leu Ala Lys Ile Pro Arg Arg Glu 20 25 30 Glu Gly Glu Glu Ala Glu Glu Trp Leu Ser Ser Leu Arg Ala His Val 35 40 45 Val Arg Thr Gly Ile Gly Arg Ala Arg Ala Glu Leu Phe Glu Lys Gln 50 55 60 Ile Val Gln His Gly Gly Gln Leu Cys Pro Ala Gln Gly Pro Gly Val 65 70 75 80 Thr His Ile Val Val Asp Glu Gly Met Asp Tyr Glu Arg Ala Leu Arg 85 90 95 Leu Leu Arg Leu Pro Gln Leu Pro Pro Gly Ala Gln Leu Val Lys Ser 100 105 110 Ala Trp Leu Ser Leu Cys Leu Gln Glu Arg Arg Leu Val Asp Val Ala 115 120 125 Gly Phe Ser Ile Phe Ile Pro Ser Arg Tyr Leu Asp His Pro Gln Pro 130 135 140 Ser Lys Ala Glu Gln Asp Ala Ser Ile Pro Pro Gly Thr His Glu Ala 145 150 155 160 Leu Leu Gln Thr Ala Leu Ser Pro Pro Pro Pro Pro Thr Arg Pro Val 165 170 175 Ser Pro Pro Gln Lys Ala Lys Glu Ala Pro Asn Thr Gln Ala Gln Pro 180 185 190 Ile Ser Asp Asp Glu Ala Ser Asp Gly Glu Glu Thr Gln Val Ser Ala 195 200 205 Ala Asp Leu Glu Ala Leu Ile Ser Gly His Tyr Pro Thr Ser Leu Glu 210 215 220 Gly Asp Cys Glu Pro Ser Pro Ala Pro Ala Val Leu Asp Lys Trp Val 225 230 235 240 Cys Ala Gln Pro Ser Ser Gln Lys Ala Thr Asn His Asn Leu His Ile 245 250 255 Thr Glu Lys Leu Glu Val Leu Ala Lys Ala Tyr Ser Val Gln Gly Asp 260 265 270 Lys Trp Arg Ala Leu Gly Tyr Ala Lys Ala Ile Asn Ala Leu Lys Ser 275 280 285 Phe His Lys Pro Val Thr Ser Tyr Gln Glu Ala Cys Ser Ile Pro Gly 290 295 300 Ile Gly Lys Arg Met Ala Glu Lys Ile Ile Glu Ile Leu Glu Ser Gly 305 310 315 320 His Leu Arg Lys Leu Asp His Ile Ser Glu Ser Val Pro Val Leu Glu 325 330 335 Leu Phe Ser Asn Ile Trp Gly Ala Gly Thr Lys Thr Ala Gln Met Trp 340 345 350 Tyr Gln Gln Gly Phe Arg Ser Leu Glu Asp Ile Arg Ser Gln Ala Ser 355 360 365 Leu Thr Thr Gln Gln Ala Ile Gly Leu Lys His Tyr Ser Asp Phe Leu 370 375 380 Glu Arg Met Pro Arg Glu Glu Ala Thr Glu Ile Glu Gln Thr Val Gln 385 390 395 400 Lys Ala Ala Gln Ala Phe Asn Ser Gly Leu Leu Cys Val Ala Cys Gly 405 410 415 Ser Tyr Arg Arg Gly Lys Ala Thr Cys Gly Asp Val Asp Val Leu Ile 420 425 430 Thr His Pro Asp Gly Arg Ser His Arg Gly Ile Phe Ser Arg Leu Leu 435 440 445 Asp Ser Leu Arg Gln Glu Gly Phe Leu Thr Asp Asp Leu Val Ser Gln 450 455 460 Glu Glu Asn Gly Gln Gln Gln Lys Tyr Leu Gly Val Cys Arg Leu Pro 465 470 475 480 Gly Pro Gly Arg Arg His Arg Arg Leu Asp Ile Ile Val Val Pro Tyr 485 490 495 Ser Glu Phe Ala Cys Ala Leu Leu Tyr Phe Thr Gly Ser Ala His Phe 500 505 510 Asn Arg Ser Met Arg Ala Leu Ala Lys Thr Lys Gly Met Ser Leu Ser 515 520 525 Glu His Ala Leu Ser Thr Ala Val Val Arg Asn Thr His Gly Cys Lys 530 535 540 Val Gly Pro Gly Arg Val Leu Pro Thr Pro Thr Glu Lys Asp Val Phe 545 550 555 560 Arg Leu Leu Gly Leu Pro Tyr Arg Glu Pro Ala Glu Arg Asp Trp 565 570 575 <210> 947 <211> 515 <212> PRT <213> Homo sapiens <400> 947 Met Asp Pro Arg Gly Ile Leu Lys Ala Phe Pro Lys Arg Gln Lys Ile 1 5 10 15 His Ala Asp Ala Ser Ser Lys Val Leu Ala Lys Ile Pro Arg Arg Glu 20 25 30 Glu Gly Glu Glu Ala Glu Glu Trp Leu Ser Ser Leu Arg Ala His Val 35 40 45 Val Arg Thr Gly Ile Gly Arg Ala Arg Ala Glu Leu Phe Glu Lys Gln 50 55 60 Ile Val Gln His Gly Gly Gln Leu Cys Pro Ala Gln Gly Pro Gly Val 65 70 75 80 Thr His Ile Val Val Asp Glu Gly Met Asp Tyr Glu Arg Ala Leu Arg 85 90 95 Leu Leu Arg Leu Pro Gln Leu Pro Pro Gly Ala Gln Leu Val Lys Ser 100 105 110 Ala Trp Leu Ser Leu Cys Leu Gln Glu Arg Arg Leu Val Asp Val Ala 115 120 125 Gly Phe Ser Ile Phe Ile Pro Ser Arg Tyr Leu Asp His Pro Gln Pro 130 135 140 Ser Lys Ala Glu Gln Asp Ala Ser Ile Pro Pro Gly Thr His Glu Ala 145 150 155 160 Leu Leu Gln Thr Ala Leu Ser Pro Pro Pro Pro Pro Thr Arg Pro Val 165 170 175 Ser Pro Pro Gln Lys Ala Lys Glu Ala Pro Asn Thr Gln Ala Gln Pro 180 185 190 Ile Ser Asp Asp Glu Ala Ser Asp Gly Glu Glu Thr Gln Val Ser Ala 195 200 205 Ala Asp Leu Glu Ala Leu Ile Ser Gly His Tyr Pro Thr Ser Leu Glu 210 215 220 Gly Asp Cys Glu Pro Ser Pro Ala Pro Ala Val Leu Asp Lys Trp Val 225 230 235 240 Cys Ala Gln Pro Ser Ser Gln Lys Ala Thr Asn His Asn Leu His Ile 245 250 255 Thr Glu Lys Leu Glu Val Leu Ala Lys Ala Tyr Ser Val Gln Gly Asp 260 265 270 Lys Trp Arg Ala Leu Gly Tyr Ala Lys Ala Ile Asn Ala Leu Lys Ser 275 280 285 Phe His Lys Pro Val Thr Ser Tyr Gln Glu Ala Cys Ser Ile Pro Gly 290 295 300 Ile Gly Lys Arg Met Ala Glu Lys Ile Ile Glu Ile Leu Glu Ser Gly 305 310 315 320 His Leu Arg Lys Leu Asp His Ile Ser Glu Ser Val Pro Val Leu Glu 325 330 335 Leu Phe Ser Asn Ile Trp Gly Ala Gly Thr Lys Thr Ala Gln Met Trp 340 345 350 Tyr Gln Gln Gly Phe Arg Ser Leu Glu Asp Ile Arg Ser Gln Ala Ser 355 360 365 Leu Thr Thr Gln Gln Ala Ile Gly Leu Lys His Tyr Ser Asp Phe Leu 370 375 380 Glu Arg Met Pro Arg Glu Glu Ala Thr Glu Ile Glu Gln Thr Val Gln 385 390 395 400 Lys Ala Ala Gln Ala Phe Asn Ser Gly Leu Leu Cys Val Ala Cys Gly 405 410 415 Ser Tyr Arg Arg Gly Lys Ala Thr Cys Gly Asp Val Asp Val Leu Ile 420 425 430 Thr His Pro Asp Gly Arg Ser His Arg Gly Ile Phe Ser Arg Leu Leu 435 440 445 Asp Ser Leu Arg Gln Glu Gly Phe Leu Thr Asp Asp Leu Val Ser Gln 450 455 460 Glu Glu Asn Gly Gln Gln Gln Lys Tyr Leu Gly Val Cys Arg Leu Pro 465 470 475 480 Gly Pro Gly Arg Arg His Arg Arg Leu Asp Ile Ile Val Val Pro Tyr 485 490 495 Ser Glu Phe Ala Cys Ala Leu Gln Gly Gly Ala Trp Pro Ser Ala Ala 500 505 510 His Ser His 515 <210> 948 <211> 487 <212> PRT <213> Homo sapiens <400> 948 Met Asp Tyr Glu Arg Ala Leu Arg Leu Leu Arg Leu Pro Gln Leu Pro 1 5 10 15 Pro Gly Ala Gln Leu Val Lys Ser Ala Trp Leu Ser Leu Cys Leu Gln 20 25 30 Glu Arg Arg Leu Val Asp Val Ala Gly Phe Ser Ile Phe Ile Pro Ser 35 40 45 Arg Tyr Leu Asp His Pro Gln Pro Ser Lys Ala Glu Gln Asp Ala Ser 50 55 60 Ile Pro Pro Gly Thr His Glu Ala Leu Leu Gln Thr Ala Leu Ser Pro 65 70 75 80 Pro Pro Pro Pro Thr Arg Pro Val Ser Pro Pro Gln Lys Ala Lys Glu 85 90 95 Ala Pro Asn Thr Gln Ala Gln Pro Ile Ser Asp Asp Glu Ala Ser Asp 100 105 110 Gly Glu Glu Thr Gln Val Ser Ala Ala Asp Leu Glu Ala Leu Ile Ser 115 120 125 Gly His Tyr Pro Thr Ser Leu Glu Gly Asp Cys Glu Pro Ser Pro Ala 130 135 140 Pro Ala Val Leu Asp Lys Trp Val Cys Ala Gln Pro Ser Ser Gln Lys 145 150 155 160 Ala Thr Asn His Asn Leu His Ile Thr Glu Lys Leu Glu Val Leu Ala 165 170 175 Lys Ala Tyr Ser Val Gln Gly Asp Lys Trp Arg Ala Leu Gly Tyr Ala 180 185 190 Lys Ala Ile Asn Ala Leu Lys Ser Phe His Lys Pro Val Thr Ser Tyr 195 200 205 Gln Glu Ala Cys Ser Ile Pro Gly Ile Gly Lys Arg Met Ala Glu Lys 210 215 220 Ile Ile Glu Ile Leu Glu Ser Gly His Leu Arg Lys Leu Asp His Ile 225 230 235 240 Ser Glu Ser Val Pro Val Leu Glu Leu Phe Ser Asn Ile Trp Gly Ala 245 250 255 Gly Thr Lys Thr Ala Gln Met Trp Tyr Gln Gln Gly Phe Arg Ser Leu 260 265 270 Glu Asp Ile Arg Ser Gln Ala Ser Leu Thr Thr Gln Gln Ala Ile Gly 275 280 285 Leu Lys His Tyr Ser Asp Phe Leu Glu Arg Met Pro Arg Glu Glu Ala 290 295 300 Thr Glu Ile Glu Gln Thr Val Gln Lys Ala Ala Gln Ala Phe Asn Ser 305 310 315 320 Gly Leu Leu Cys Val Ala Cys Gly Ser Tyr Arg Arg Gly Lys Ala Thr 325 330 335 Cys Gly Asp Val Asp Val Leu Ile Thr His Pro Asp Gly Arg Ser His 340 345 350 Arg Gly Ile Phe Ser Arg Leu Leu Asp Ser Leu Arg Gln Glu Gly Phe 355 360 365 Leu Thr Asp Asp Leu Val Ser Gln Glu Glu Asn Gly Gln Gln Gln Lys 370 375 380 Tyr Leu Gly Val Cys Arg Leu Pro Gly Pro Gly Arg Arg His Arg Arg 385 390 395 400 Leu Asp Ile Ile Val Val Pro Tyr Ser Glu Phe Ala Cys Ala Leu Leu 405 410 415 Tyr Phe Thr Gly Ser Ala His Phe Asn Arg Ser Met Arg Ala Leu Ala 420 425 430 Lys Thr Lys Gly Met Ser Leu Ser Glu His Ala Leu Ser Thr Ala Val 435 440 445 Val Arg Asn Thr His Gly Cys Lys Val Gly Pro Gly Arg Val Leu Pro 450 455 460 Thr Pro Thr Glu Lys Asp Val Phe Arg Leu Leu Gly Leu Pro Tyr Arg 465 470 475 480 Glu Pro Ala Glu Arg Asp Trp 485 <210> 949 <211> 248 <212> PRT <213> Homo sapiens <400> 949 Met Glu Ala Leu Cys Val Cys Ser Leu Met Pro Leu His Trp Ser Trp 1 5 10 15 Ile Leu Thr Ala Ser His Leu Ala Ala Phe Phe Gln Gly Phe Arg Ser 20 25 30 Leu Glu Asp Ile Arg Ser Gln Ala Ser Leu Thr Thr Gln Gln Ala Ile 35 40 45 Gly Leu Lys His Tyr Ser Asp Phe Leu Glu Arg Met Pro Arg Glu Glu 50 55 60 Ala Thr Glu Ile Glu Gln Thr Val Gln Lys Ala Ala Gln Ala Phe Asn 65 70 75 80 Ser Gly Leu Leu Cys Val Ala Cys Gly Ser Tyr Arg Arg Gly Lys Ala 85 90 95 Thr Cys Gly Asp Val Asp Val Leu Ile Thr His Pro Asp Gly Arg Ser 100 105 110 His Arg Gly Ile Phe Ser Arg Leu Leu Asp Ser Leu Arg Gln Glu Gly 115 120 125 Phe Leu Thr Asp Asp Leu Val Ser Gln Glu Glu Asn Gly Gln Gln Gln 130 135 140 Lys Tyr Leu Gly Val Cys Arg Leu Pro Gly Pro Gly Arg Arg His Arg 145 150 155 160 Arg Leu Asp Ile Ile Val Val Pro Tyr Ser Glu Phe Ala Cys Ala Leu 165 170 175 Leu Tyr Phe Thr Gly Ser Ala His Phe Asn Arg Ser Met Arg Ala Leu 180 185 190 Ala Lys Thr Lys Gly Met Ser Leu Ser Glu His Ala Leu Ser Thr Ala 195 200 205 Val Val Arg Asn Thr His Gly Cys Lys Val Gly Pro Gly Arg Val Leu 210 215 220 Pro Thr Pro Thr Glu Lys Asp Val Phe Arg Leu Leu Gly Leu Pro Tyr 225 230 235 240 Arg Glu Pro Ala Glu Arg Asp Trp 245 <210> 950 <211> 575 <212> PRT <213> Homo sapiens <400> 950 Met Asp Pro Arg Gly Ile Leu Lys Ala Phe Pro Lys Arg Gln Lys Ile 1 5 10 15 His Ala Asp Ala Ser Ser Lys Val Leu Ala Lys Ile Pro Arg Arg Glu 20 25 30 Glu Gly Glu Glu Ala Glu Glu Trp Leu Ser Ser Leu Arg Ala His Val 35 40 45 Val Arg Thr Gly Ile Gly Arg Ala Arg Ala Glu Leu Phe Glu Lys Gln 50 55 60 Ile Val Gln His Gly Gly Gln Leu Cys Pro Ala Gln Gly Pro Gly Val 65 70 75 80 Thr His Ile Val Val Asp Glu Gly Met Asp Tyr Glu Arg Ala Leu Arg 85 90 95 Leu Leu Arg Leu Pro Gln Leu Pro Pro Gly Ala Gln Leu Val Lys Ser 100 105 110 Ala Trp Leu Ser Leu Cys Leu Gln Glu Arg Arg Leu Val Asp Val Ala 115 120 125 Gly Phe Ser Ile Phe Ile Pro Ser Arg Cys Leu Asp His Pro Gln Pro 130 135 140 Ser Lys Ala Glu Gln Asp Ala Ser Ile Pro Pro Gly Thr His Glu Ala 145 150 155 160 Leu Leu Gln Thr Ala Leu Ser Pro Pro Pro Pro Pro Thr Arg Pro Val 165 170 175 Ser Pro Pro Gln Lys Ala Lys Glu Ala Pro Asn Thr Gln Ala Gln Pro 180 185 190 Ile Ser Asp Asp Glu Ala Ser Asp Gly Glu Glu Thr Gln Val Ser Ala 195 200 205 Ala Asp Leu Glu Ala Leu Ile Ser Gly His Tyr Pro Thr Ser Leu Glu 210 215 220 Gly Asp Cys Glu Pro Ser Pro Ala Pro Ala Val Leu Asp Lys Trp Val 225 230 235 240 Cys Ala Gln Pro Ser Ser Gln Lys Ala Thr Asn His Asn Leu His Ile 245 250 255 Thr Glu Lys Leu Glu Val Leu Ala Lys Ala Tyr Ser Val Gln Gly Asp 260 265 270 Lys Trp Arg Ala Leu Gly Tyr Ala Lys Ala Ile Asn Ala Leu Lys Ser 275 280 285 Phe His Lys Pro Val Thr Ser Tyr Gln Glu Ala Cys Ser Ile Pro Gly 290 295 300 Ile Gly Lys Arg Met Ala Glu Lys Ile Ile Glu Ile Leu Glu Ser Gly 305 310 315 320 His Leu Arg Lys Leu Asp His Ile Ser Glu Ser Val Pro Val Leu Glu 325 330 335 Leu Phe Ser Asn Ile Trp Gly Ala Gly Thr Lys Thr Ala Gln Met Trp 340 345 350 Tyr Gln Gln Gly Phe Arg Ser Leu Glu Asp Ile Arg Ser Gln Ala Ser 355 360 365 Leu Thr Thr Gln Gln Ala Ile Gly Leu Lys His Tyr Ser Asp Phe Leu 370 375 380 Glu Arg Met Pro Arg Glu Glu Ala Thr Glu Ile Glu Gln Thr Val Gln 385 390 395 400 Lys Ala Ala Gln Ala Phe Asn Ser Gly Leu Leu Cys Val Ala Cys Gly 405 410 415 Ser Tyr Arg Arg Gly Lys Ala Thr Cys Gly Asp Val Asp Val Leu Ile 420 425 430 Thr His Pro Asp Gly Arg Ser His Arg Gly Ile Phe Ser Arg Leu Leu 435 440 445 Asp Ser Leu Arg Gln Glu Gly Phe Leu Thr Asp Asp Leu Val Ser Gln 450 455 460 Glu Glu Asn Gly Gln Gln Gln Lys Tyr Leu Gly Val Cys Arg Leu Pro 465 470 475 480 Gly Pro Gly Arg Arg His Arg Arg Leu Asp Ile Ile Val Val Pro Tyr 485 490 495 Ser Glu Phe Ala Cys Ala Leu Leu Tyr Phe Thr Gly Ser Ala His Phe 500 505 510 Asn Arg Ser Met Arg Ala Leu Ala Lys Thr Lys Gly Met Ser Leu Ser 515 520 525 Glu His Ala Leu Ser Thr Ala Val Val Arg Asn Thr His Gly Cys Lys 530 535 540 Val Gly Pro Gly Arg Val Leu Pro Thr Pro Thr Glu Lys Asp Val Phe 545 550 555 560 Arg Leu Leu Gly Leu Pro Tyr Arg Glu Pro Ala Glu Arg Asp Trp 565 570 575 <210> 951 <211> 298 <212> PRT <213> Homo sapiens <400> 951 Met His His Gln Lys Tyr Leu Gln Arg Phe Leu Gly Gly Lys Arg Glu 1 5 10 15 Lys Lys Gln Lys Glu Ala Cys Ser Ile Pro Gly Ile Gly Lys Arg Met 20 25 30 Ala Glu Lys Ile Ile Glu Ile Leu Glu Ser Gly His Leu Arg Lys Leu 35 40 45 Asp His Ile Ser Glu Ser Val Pro Val Leu Glu Leu Phe Ser Asn Ile 50 55 60 Trp Gly Ala Gly Thr Lys Thr Ala Gln Met Trp Tyr Gln Gln Gly Phe 65 70 75 80 Arg Ser Leu Glu Asp Ile Arg Ser Gln Ala Ser Leu Thr Thr Gln Gln 85 90 95 Ala Ile Gly Leu Lys His Tyr Ser Asp Phe Leu Glu Arg Met Pro Arg 100 105 110 Glu Glu Ala Thr Glu Ile Glu Gln Thr Val Gln Lys Ala Ala Gln Ala 115 120 125 Phe Asn Ser Gly Leu Leu Cys Val Ala Cys Gly Ser Tyr Arg Arg Gly 130 135 140 Lys Ala Thr Cys Gly Asp Val Asp Val Leu Ile Thr His Pro Asp Gly 145 150 155 160 Arg Ser His Arg Gly Ile Phe Ser Arg Leu Leu Asp Ser Leu Arg Gln 165 170 175 Glu Gly Phe Leu Thr Asp Asp Leu Val Ser Gln Glu Glu Asn Gly Gln 180 185 190 Gln Gln Lys Tyr Leu Gly Val Cys Arg Leu Pro Gly Pro Gly Arg Arg 195 200 205 His Arg Arg Leu Asp Ile Ile Val Val Pro Tyr Ser Glu Phe Ala Cys 210 215 220 Ala Leu Leu Tyr Phe Thr Gly Ser Ala His Phe Asn Arg Ser Met Arg 225 230 235 240 Ala Leu Ala Lys Thr Lys Gly Met Ser Leu Ser Glu His Ala Leu Ser 245 250 255 Thr Ala Val Val Arg Asn Thr His Gly Cys Lys Val Gly Pro Gly Arg 260 265 270 Val Leu Pro Thr Pro Thr Glu Lys Asp Val Phe Arg Leu Leu Gly Leu 275 280 285 Pro Tyr Arg Glu Pro Ala Glu Arg Asp Trp 290 295 <210> 952 <211> 494 <212> PRT <213> Homo sapiens <400> 952 Met Leu Pro Lys Arg Arg Arg Ala Arg Val Gly Ser Pro Ser Gly Asp 1 5 10 15 Ala Ala Ser Ser Thr Pro Pro Ser Thr Arg Phe Pro Gly Val Ala Ile 20 25 30 Tyr Leu Val Glu Pro Arg Met Gly Arg Ser Arg Arg Ala Phe Leu Thr 35 40 45 Gly Leu Ala Arg Ser Lys Gly Phe Arg Val Leu Asp Ala Cys Ser Ser 50 55 60 Glu Ala Thr His Val Val Met Glu Glu Thr Ser Ala Glu Glu Ala Val 65 70 75 80 Ser Trp Gln Glu Arg Arg Met Ala Ala Ala Pro Pro Gly Cys Thr Pro 85 90 95 Pro Ala Leu Leu Asp Ile Ser Trp Leu Thr Glu Ser Leu Gly Ala Gly 100 105 110 Gln Pro Val Pro Val Glu Cys Arg His Arg Leu Glu Val Ala Gly Pro 115 120 125 Arg Lys Gly Pro Leu Ser Pro Ala Trp Met Pro Ala Tyr Ala Cys Gln 130 135 140 Arg Pro Thr Pro Leu Thr His His Asn Thr Gly Leu Ser Glu Ala Leu 145 150 155 160 Glu Ile Leu Ala Glu Ala Ala Gly Phe Glu Gly Ser Glu Gly Arg Leu 165 170 175 Leu Thr Phe Cys Arg Ala Ala Ser Val Leu Lys Ala Leu Pro Ser Pro 180 185 190 Val Thr Thr Leu Ser Gln Leu Gln Gly Leu Pro His Phe Gly Glu His 195 200 205 Ser Ser Arg Val Val Gln Glu Leu Leu Glu His Gly Val Cys Glu Glu 210 215 220 Val Glu Arg Val Arg Arg Ser Glu Arg Tyr Gln Thr Met Lys Leu Phe 225 230 235 240 Thr Gln Ile Phe Gly Val Gly Val Lys Thr Ala Asp Arg Trp Tyr Arg 245 250 255 Glu Gly Leu Arg Thr Leu Asp Asp Leu Arg Glu Gln Pro Gln Lys Leu 260 265 270 Thr Gln Gln Gln Lys Ala Gly Leu Gln His His Gln Asp Leu Ser Thr 275 280 285 Pro Val Leu Arg Ser Asp Val Asp Ala Leu Gln Gln Val Val Glu Glu 290 295 300 Ala Val Gly Gln Ala Leu Pro Gly Ala Thr Val Thr Leu Thr Gly Gly 305 310 315 320 Phe Arg Arg Gly Lys Leu Gln Gly His Asp Val Asp Phe Leu Ile Thr 325 330 335 His Pro Lys Glu Gly Gln Glu Ala Gly Leu Leu Pro Arg Val Met Cys 340 345 350 Arg Leu Gln Asp Gln Gly Leu Ile Leu Tyr His Gln His Gln His Ser 355 360 365 Cys Cys Glu Ser Pro Thr Arg Leu Ala Gln Gln Ser His Met Asp Ala 370 375 380 Phe Glu Arg Ser Phe Cys Ile Phe Arg Leu Pro Gln Pro Pro Gly Ala 385 390 395 400 Ala Val Gly Gly Ser Thr Arg Pro Cys Pro Ser Trp Lys Ala Val Arg 405 410 415 Val Asp Leu Val Val Ala Pro Val Ser Gln Phe Pro Phe Ala Leu Leu 420 425 430 Gly Trp Thr Gly Ser Lys Leu Phe Gln Arg Glu Leu Arg Arg Phe Ser 435 440 445 Arg Lys Glu Lys Gly Leu Trp Leu Asn Ser His Gly Leu Phe Asp Pro 450 455 460 Glu Gln Lys Thr Phe Phe Gln Ala Ala Ser Glu Glu Asp Ile Phe Arg 465 470 475 480 His Leu Gly Leu Glu Tyr Leu Pro Pro Glu Gln Arg Asn Ala 485 490 <210> 953 <211> 523 <212> PRT <213> Homo sapiens <400> 953 Val Ser Leu Cys Val Arg Ser Ala Leu Leu Glu Ala Val Val Pro Met 1 5 10 15 Leu Pro Lys Arg Arg Arg Ala Arg Val Gly Ser Pro Ser Gly Asp Ala 20 25 30 Ala Ser Ser Thr Pro Pro Ser Thr Arg Phe Pro Gly Val Ala Ile Tyr 35 40 45 Leu Val Glu Pro Arg Met Gly Arg Ser Arg Arg Ala Phe Leu Thr Gly 50 55 60 Leu Ala Arg Ser Lys Gly Phe Arg Val Leu Asp Ala Cys Ser Ser Glu 65 70 75 80 Ala Thr His Val Val Met Glu Glu Thr Ser Ala Glu Glu Ala Val Ser 85 90 95 Trp Gln Glu Arg Arg Met Ala Ala Ala Pro Pro Gly Cys Thr Pro Pro 100 105 110 Ala Leu Leu Asp Ile Ser Trp Leu Thr Glu Ser Leu Gly Ala Gly Gln 115 120 125 Pro Val Pro Val Glu Cys Arg His Arg Leu Glu Val Ala Gly Pro Arg 130 135 140 Lys Gly Pro Leu Ser Pro Ala Trp Met Pro Ala Tyr Ala Cys Gln Arg 145 150 155 160 Pro Thr Pro Leu Thr His His Asn Thr Gly Leu Ser Glu Ala Leu Glu 165 170 175 Ile Leu Ala Glu Ala Ala Gly Phe Glu Gly Ser Glu Gly Arg Leu Leu 180 185 190 Thr Phe Cys Arg Ala Ala Ser Val Leu Lys Ala Leu Pro Ser Pro Val 195 200 205 Thr Thr Leu Ser Gln Leu Gln Gly Leu Pro His Phe Gly Glu His Ser 210 215 220 Ser Arg Val Val Gln Glu Leu Leu Glu His Gly Val Cys Glu Glu Val 225 230 235 240 Glu Arg Val Arg Arg Ser Glu Arg Ala Pro Ala Pro Pro Gly Pro Glu 245 250 255 His Pro Ser Pro Ala Val Arg Cys Arg Cys Pro Ala Ala Gly Gly Gly 260 265 270 Gly Ser Cys Gly Ala Gly Pro Ala Trp Gly His Arg His Ala Asp Arg 275 280 285 Arg Leu Pro Gln Gly Leu Ile Leu Tyr His Gln His Gln His Ser Cys 290 295 300 Cys Glu Ser Pro Thr Arg Leu Ala Gln Gln Ser His Met Asp Ala Phe 305 310 315 320 Glu Arg Ser Phe Cys Ile Phe Arg Leu Pro Gln Pro Pro Gly Ala Ala 325 330 335 Val Gly Gly Ser Thr Arg Pro Cys Pro Ser Trp Lys Ala Val Arg Val 340 345 350 Asp Leu Val Val Ala Pro Val Ser Gln Phe Pro Phe Ala Leu Leu Gly 355 360 365 Trp Thr Gly Ser Lys Leu Phe Gln Arg Glu Leu Arg Arg Phe Ser Arg 370 375 380 Lys Glu Lys Gly Leu Trp Leu Asn Ser His Gly Leu Phe Asp Pro Glu 385 390 395 400 Gln Gly Ser Ser Ser Gly Lys Thr Pro Arg Ser Arg Lys Ser Cys Phe 405 410 415 Cys Cys Arg Arg His Phe Ser Lys Arg Leu Gln Arg Lys Thr Ser Ser 420 425 430 Asp Thr Trp Ala Leu Ser Thr Phe Leu Gln Ser Arg Glu Thr Pro Glu 435 440 445 Pro Ala Cys Val Pro His Phe His Ser Gly Asn Trp Ala Ala Pro Asn 450 455 460 Leu Ala Thr Glu Cys Leu Gln Ala Asp Met Leu Pro Pro Asp Pro His 465 470 475 480 Leu His Pro Ser Pro Pro Arg Pro Gly Ser Ser Gly Gly Gln Leu Cys 485 490 495 Leu Gln Asp Gln Leu Ser Pro Cys Trp Cys Ala Ala Gly Cys Asp Glu 500 505 510 Val Gly Ala Leu Ser Ala Ser Leu Ile Thr Val 515 520 <210> 954 <211> 457 <212> PRT <213> Homo sapiens <400> 954 Met Leu Pro Lys Arg Arg Arg Ala Arg Val Gly Ser Pro Ser Gly Asp 1 5 10 15 Ala Ala Ser Ser Thr Pro Pro Ser Thr Arg Phe Pro Gly Val Ala Ile 20 25 30 Tyr Leu Val Glu Pro Arg Met Gly Arg Ser Arg Arg Ala Phe Leu Thr 35 40 45 Gly Leu Ala Arg Ser Lys Gly Phe Arg Val Leu Asp Ala Cys Ser Ser 50 55 60 Glu Ala Thr His Val Val Met Glu Glu Thr Ser Ala Glu Glu Ala Val 65 70 75 80 Ser Trp Gln Glu Arg Arg Met Ala Ala Ala Pro Pro Gly Cys Thr Pro 85 90 95 Pro Ala Leu Leu Asp Ile Ser Trp Leu Thr Glu Ser Leu Gly Ala Gly 100 105 110 Gln Pro Val Pro Val Glu Cys Arg His Arg Leu Glu Val Ala Gly Pro 115 120 125 Arg Lys Gly Pro Leu Ser Pro Ala Trp Met Pro Ala Tyr Ala Cys Gln 130 135 140 Arg Pro Thr Pro Leu Thr His His Asn Thr Gly Leu Ser Glu Ala Leu 145 150 155 160 Glu Ile Leu Ala Glu Ala Ala Gly Phe Glu Gly Ser Glu Gly Arg Leu 165 170 175 Leu Thr Phe Cys Arg Ala Ala Ser Val Leu Lys Ala Leu Pro Ser Pro 180 185 190 Val Thr Thr Leu Ser Gln Leu Gln Gly Leu Pro His Phe Gly Glu His 195 200 205 Ser Ser Arg Val Val Gln Glu Leu Leu Glu His Gly Val Cys Glu Glu 210 215 220 Val Glu Arg Val Arg Arg Ser Glu Arg Tyr Gln Thr Met Lys Leu Phe 225 230 235 240 Thr Gln Ile Phe Gly Val Gly Val Lys Thr Ala Asp Arg Trp Tyr Arg 245 250 255 Glu Gly Leu Arg Thr Leu Asp Asp Leu Arg Glu Gln Pro Gln Lys Leu 260 265 270 Thr Gln Gln Gln Lys Ala Ala Pro Pro Gly Pro Glu His Pro Ser Pro 275 280 285 Ala Val Arg Cys Arg Cys Pro Ala Ala Gly Gly Gly Gly Ser Cys Gly 290 295 300 Ala Gly Pro Ala Trp Gly His Arg His Ala Asp Arg Arg Leu Pro Gln 305 310 315 320 Gly Leu Ile Leu Tyr His Gln His Gln His Ser Cys Cys Glu Ser Pro 325 330 335 Thr Arg Leu Ala Gln Gln Ser His Met Asp Ala Phe Glu Arg Ser Phe 340 345 350 Cys Ile Phe Arg Leu Pro Gln Pro Pro Gly Ala Ala Val Gly Gly Ser 355 360 365 Thr Arg Pro Cys Pro Ser Trp Lys Ala Val Arg Val Asp Leu Val Val 370 375 380 Ala Pro Val Ser Gln Phe Pro Phe Ala Leu Leu Gly Trp Thr Gly Ser 385 390 395 400 Lys Leu Phe Gln Arg Glu Leu Arg Arg Phe Ser Arg Lys Glu Lys Gly 405 410 415 Leu Trp Leu Asn Ser His Gly Leu Phe Asp Pro Glu Gln Lys Thr Phe 420 425 430 Phe Gln Ala Ala Ser Glu Glu Asp Ile Phe Arg His Leu Gly Leu Glu 435 440 445 Tyr Leu Pro Pro Glu Gln Arg Asn Ala 450 455 <210> 955 <211> 268 <212> PRT <213> Homo sapiens <400> 955 Met Leu Pro Lys Arg Arg Arg Ala Arg Val Gly Ser Pro Ser Gly Asp 1 5 10 15 Ala Ala Ser Ser Thr Pro Pro Ser Thr Arg Phe Pro Gly Val Ala Ile 20 25 30 Tyr Leu Val Glu Pro Arg Met Gly Arg Ser Arg Arg Ala Phe Leu Thr 35 40 45 Gly Leu Ala Arg Ser Lys Gly Phe Arg Val Leu Asp Ala Cys Ser Ser 50 55 60 Glu Ala Thr His Val Val Met Glu Glu Thr Ser Ala Glu Glu Ala Val 65 70 75 80 Ser Trp Gln Glu Arg Arg Met Ala Ala Ala Pro Pro Gly Cys Thr Pro 85 90 95 Pro Ala Leu Leu Asp Ile Ser Trp Leu Thr Glu Ser Leu Gly Ala Gly 100 105 110 Gln Pro Val Pro Val Glu Cys Arg His Arg Leu Glu Val Ala Gly Pro 115 120 125 Arg Lys Gly Pro Leu Ser Pro Ala Trp Met Pro Ala Tyr Ala Cys Gln 130 135 140 Arg Pro Thr Pro Leu Thr His His Asn Thr Gly Leu Ser Glu Ala Leu 145 150 155 160 Glu Ile Leu Ala Glu Ala Ala Gly Phe Glu Gly Ser Glu Gly Arg Leu 165 170 175 Leu Thr Phe Cys Arg Ala Ala Ser Val Leu Lys Ala Leu Pro Ser Pro 180 185 190 Val Thr Thr Leu Ser Gln Leu Gln Gly Leu Pro His Phe Gly Glu His 195 200 205 Ser Ser Arg Val Val Gln Glu Leu Leu Glu His Gly Val Cys Glu Glu 210 215 220 Val Glu Arg Val Arg Arg Ser Glu Arg Tyr Gln Thr Met Lys Val Arg 225 230 235 240 Arg Ala Gly Leu Gly Pro Thr Pro Gly Met Ser Cys Pro Gly Asn Asp 245 250 255 Asn Thr Val His Thr Met His Gly Glu Ala Asn Arg 260 265 <210> 956 <211> 494 <212> PRT <213> Homo sapiens <400> 956 Met Leu Pro Lys Arg Arg Arg Ala Arg Val Gly Ser Pro Ser Gly Asp 1 5 10 15 Ala Ala Ser Ser Thr Pro Pro Ser Thr Arg Phe Pro Gly Val Ala Ile 20 25 30 Tyr Leu Val Glu Pro Arg Met Gly Arg Ser Arg Arg Ala Phe Leu Thr 35 40 45 Gly Leu Ala Arg Ser Lys Gly Phe Arg Val Leu Asp Ala Cys Ser Ser 50 55 60 Glu Ala Thr His Val Val Met Glu Glu Thr Ser Ala Glu Glu Ala Val 65 70 75 80 Ser Trp Gln Glu Arg Arg Met Ala Ala Ala Pro Pro Gly Cys Thr Pro 85 90 95 Pro Ala Leu Leu Asp Ile Ser Trp Leu Thr Glu Ser Leu Gly Ala Gly 100 105 110 Gln Pro Val Pro Val Glu Cys Arg His Arg Leu Glu Val Ala Gly Pro 115 120 125 Arg Lys Gly Pro Leu Ser Pro Ala Trp Met Pro Ala Tyr Ala Cys Gln 130 135 140 Arg Pro Thr Pro Leu Thr His His Asn Thr Gly Leu Ser Glu Ala Leu 145 150 155 160 Glu Ile Leu Ala Glu Ala Ala Gly Phe Glu Gly Ser Glu Gly Arg Leu 165 170 175 Leu Thr Phe Cys Arg Ala Ala Ser Val Leu Lys Ala Leu Pro Ser Pro 180 185 190 Val Thr Thr Leu Ser Gln Leu Gln Gly Leu Pro His Phe Gly Glu His 195 200 205 Ser Ser Arg Val Val Gln Glu Leu Leu Glu His Gly Val Cys Glu Glu 210 215 220 Val Glu Arg Val Arg Arg Ser Glu Arg Tyr Gln Thr Met Lys Leu Phe 225 230 235 240 Thr Gln Ile Phe Gly Val Gly Val Lys Thr Ala Asp Arg Trp Tyr Arg 245 250 255 Glu Gly Leu Arg Thr Leu Asp Asp Leu Arg Glu Gln Pro Gln Lys Leu 260 265 270 Thr Gln Gln Gln Lys Ala Gly Leu Gln His His Gln Asp Leu Ser Thr 275 280 285 Pro Val Leu Arg Ser Asp Val Asp Ala Leu Gln Gln Val Val Glu Glu 290 295 300 Ala Val Gly Gln Ala Leu Pro Gly Ala Thr Val Thr Leu Thr Gly Gly 305 310 315 320 Phe Arg Arg Gly Lys Leu Gln Gly His Asp Val Asp Phe Leu Ile Thr 325 330 335 His Pro Lys Glu Gly Gln Glu Ala Gly Leu Leu Pro Arg Val Met Cys 340 345 350 Arg Leu Gln Asp Gln Gly Leu Ile Leu Tyr His Gln His Gln His Ser 355 360 365 Cys Cys Glu Ser Pro Thr Arg Leu Ala Gln Gln Ser His Met Asp Ala 370 375 380 Phe Glu Arg Ser Phe Cys Ile Phe Arg Leu Pro Gln Pro Pro Gly Ala 385 390 395 400 Ala Val Gly Gly Ser Thr Arg Pro Cys Pro Ser Trp Lys Ala Val Arg 405 410 415 Val Asp Leu Val Val Ala Pro Val Ser Gln Phe Pro Phe Ala Leu Leu 420 425 430 Gly Trp Thr Gly Ser Lys Leu Phe Gln Arg Glu Leu Arg Arg Phe Ser 435 440 445 Arg Lys Glu Lys Gly Leu Trp Leu Asn Ser His Gly Leu Phe Asp Pro 450 455 460 Glu Gln Lys Thr Phe Phe Gln Ala Ala Ser Glu Glu Asp Ile Phe Arg 465 470 475 480 His Leu Gly Leu Glu Tyr Leu Pro Pro Glu Gln Arg Asn Ala 485 490 <210> 957 <211> 494 <212> PRT <213> Homo sapiens <400> 957 Met Leu Pro Lys Arg Arg Arg Ala Arg Val Gly Ser Pro Ser Gly Asp 1 5 10 15 Ala Ala Ser Ser Thr Pro Pro Ser Thr Arg Phe Pro Gly Val Ala Ile 20 25 30 Tyr Leu Val Glu Pro Arg Met Gly Arg Ser Arg Arg Ala Phe Leu Thr 35 40 45 Gly Leu Ala Arg Ser Lys Gly Phe Arg Val Leu Asp Ala Cys Ser Ser 50 55 60 Glu Ala Thr His Val Val Met Glu Glu Thr Ser Ala Glu Glu Ala Val 65 70 75 80 Ser Trp Gln Glu Arg Arg Met Ala Ala Ala Pro Pro Gly Cys Thr Pro 85 90 95 Pro Ala Leu Leu Asp Ile Ser Trp Leu Thr Glu Ser Leu Gly Ala Gly 100 105 110 Gln Pro Val Pro Val Glu Cys Arg His Arg Leu Glu Val Ala Gly Pro 115 120 125 Arg Lys Gly Pro Leu Ser Pro Ala Trp Met Pro Ala Tyr Ala Cys Gln 130 135 140 Arg Pro Thr Pro Leu Thr His His Asn Thr Gly Leu Ser Glu Ala Leu 145 150 155 160 Glu Ile Leu Ala Glu Ala Ala Gly Phe Glu Gly Ser Glu Gly Arg Leu 165 170 175 Leu Thr Phe Cys Arg Ala Ala Ser Val Leu Lys Ala Leu Pro Ser Pro 180 185 190 Val Thr Thr Leu Ser Gln Leu Gln Gly Leu Pro His Phe Gly Glu His 195 200 205 Ser Ser Arg Val Val Gln Glu Leu Leu Glu His Gly Val Cys Glu Glu 210 215 220 Val Glu Arg Val Arg Arg Ser Glu Arg Tyr Gln Thr Met Lys Leu Phe 225 230 235 240 Thr Gln Ile Phe Gly Val Gly Val Lys Thr Ala Asp Arg Trp Tyr Arg 245 250 255 Glu Gly Leu Arg Thr Leu Asp Asp Leu Arg Glu Gln Pro Gln Lys Leu 260 265 270 Thr Gln Gln Gln Lys Ala Gly Leu Gln His His Gln Asp Leu Ser Thr 275 280 285 Pro Val Leu Arg Ser Asp Val Asp Ala Leu Gln Gln Val Val Glu Glu 290 295 300 Ala Val Gly Gln Ala Leu Pro Gly Ala Thr Val Thr Leu Thr Gly Gly 305 310 315 320 Phe Arg Arg Gly Lys Leu Gln Gly His Asp Val Asp Phe Leu Ile Thr 325 330 335 His Pro Lys Glu Gly Gln Glu Ala Gly Leu Leu Pro Arg Val Met Cys 340 345 350 Arg Leu Gln Asp Gln Gly Leu Ile Leu Tyr His Gln His Gln His Ser 355 360 365 Cys Cys Glu Ser Pro Thr Arg Leu Ala Gln Gln Ser His Met Asp Ala 370 375 380 Phe Glu Arg Ser Phe Cys Ile Phe Arg Leu Pro Gln Pro Pro Gly Ala 385 390 395 400 Ala Val Gly Gly Ser Thr Arg Pro Cys Pro Ser Trp Lys Ala Val Arg 405 410 415 Val Asp Leu Val Val Ala Pro Val Ser Gln Phe Pro Phe Ala Leu Leu 420 425 430 Gly Trp Thr Gly Ser Lys Leu Phe Gln Arg Glu Leu Arg Arg Phe Ser 435 440 445 Arg Lys Glu Lys Gly Leu Trp Leu Asn Ser His Gly Leu Phe Asp Pro 450 455 460 Glu Gln Lys Thr Phe Phe Gln Ala Ala Ser Glu Glu Asp Ile Phe Arg 465 470 475 480 His Leu Gly Leu Glu Tyr Leu Pro Pro Glu Gln Arg Asn Ala 485 490 <210> 958 <211> 494 <212> PRT <213> Homo sapiens <400> 958 Met Leu Pro Lys Arg Arg Arg Ala Arg Val Gly Ser Pro Ser Gly Asp 1 5 10 15 Ala Ala Ser Ser Thr Pro Pro Ser Thr Arg Phe Pro Gly Val Ala Ile 20 25 30 Tyr Leu Val Glu Pro Arg Met Gly Arg Ser Arg Arg Ala Phe Leu Thr 35 40 45 Gly Leu Ala Arg Ser Lys Gly Phe Arg Val Leu Asp Ala Cys Ser Ser 50 55 60 Glu Ala Thr His Val Val Met Glu Glu Thr Ser Ala Glu Glu Ala Val 65 70 75 80 Ser Trp Gln Glu Arg Arg Met Ala Ala Ala Pro Pro Gly Cys Thr Pro 85 90 95 Pro Ala Leu Leu Asp Ile Ser Trp Leu Thr Glu Ser Leu Gly Ala Gly 100 105 110 Gln Pro Val Pro Val Glu Cys Arg His Arg Leu Glu Val Ala Gly Pro 115 120 125 Arg Lys Gly Pro Leu Ser Pro Ala Trp Met Pro Ala Tyr Ala Cys Gln 130 135 140 Arg Pro Thr Pro Leu Thr His His Asn Thr Gly Leu Ser Glu Ala Leu 145 150 155 160 Glu Ile Leu Ala Glu Ala Ala Gly Phe Glu Gly Ser Glu Gly Arg Leu 165 170 175 Leu Thr Phe Cys Arg Ala Ala Ser Val Leu Lys Ala Leu Pro Ser Pro 180 185 190 Val Thr Thr Leu Ser Gln Leu Gln Gly Leu Pro His Phe Gly Glu His 195 200 205 Ser Ser Arg Val Val Gln Glu Leu Leu Glu His Gly Val Cys Glu Glu 210 215 220 Val Glu Arg Val Arg Arg Ser Glu Arg Tyr Gln Thr Met Lys Leu Phe 225 230 235 240 Thr Gln Ile Phe Gly Val Gly Val Lys Thr Ala Asp Arg Trp Tyr Arg 245 250 255 Glu Gly Leu Arg Thr Leu Asp Asp Leu Arg Glu Gln Pro Gln Lys Leu 260 265 270 Thr Gln Gln Gln Lys Ala Gly Leu Gln His His Gln Asp Leu Ser Thr 275 280 285 Pro Val Leu Arg Ser Asp Val Asp Ala Leu Gln Gln Val Val Glu Glu 290 295 300 Ala Val Gly Gln Ala Leu Pro Gly Ala Thr Val Thr Leu Thr Gly Gly 305 310 315 320 Phe Arg Arg Gly Lys Leu Gln Gly His Asp Val Asp Phe Leu Ile Thr 325 330 335 His Pro Lys Glu Gly Gln Glu Ala Gly Leu Leu Pro Arg Val Met Cys 340 345 350 Arg Leu Gln Asp Gln Gly Leu Ile Leu Tyr His Gln His Gln His Ser 355 360 365 Cys Cys Glu Ser Pro Thr Arg Leu Ala Gln Gln Ser His Met Asp Ala 370 375 380 Phe Glu Arg Ser Phe Cys Ile Phe Arg Leu Pro Gln Pro Pro Gly Ala 385 390 395 400 Ala Val Gly Gly Ser Thr Arg Pro Cys Pro Ser Trp Lys Ala Val Arg 405 410 415 Val Asp Leu Val Val Ala Pro Val Ser Gln Phe Pro Phe Ala Leu Leu 420 425 430 Gly Trp Thr Gly Ser Lys Leu Phe Gln Arg Glu Leu Arg Arg Phe Ser 435 440 445 Arg Lys Glu Lys Gly Leu Trp Leu Asn Ser His Gly Leu Phe Asp Pro 450 455 460 Glu Gln Lys Thr Phe Phe Gln Ala Ala Ser Glu Glu Asp Ile Phe Arg 465 470 475 480 His Leu Gly Leu Glu Tyr Leu Pro Pro Glu Gln Arg Asn Ala 485 490 <210> 959 <211> 242 <212> PRT <213> Homo sapiens <400> 959 Met Leu Pro Lys Arg Arg Arg Ala Arg Val Gly Ser Pro Ser Gly Asp 1 5 10 15 Ala Ala Ser Ser Thr Pro Pro Ser Thr Arg Phe Pro Gly Val Ala Ile 20 25 30 Tyr Leu Val Glu Pro Arg Met Gly Arg Ser Arg Arg Ala Phe Leu Thr 35 40 45 Gly Leu Ala Arg Ser Lys Gly Phe Arg Val Leu Asp Ala Cys Ser Ser 50 55 60 Glu Ala Thr His Val Val Met Glu Glu Thr Ser Ala Glu Glu Ala Val 65 70 75 80 Ser Trp Gln Glu Arg Arg Met Ala Ala Ala Pro Pro Gly Cys Thr Pro 85 90 95 Pro Ala Leu Leu Asp Ile Ser Trp Leu Thr Glu Ser Leu Gly Ala Gly 100 105 110 Gln Pro Val Pro Val Glu Cys Arg His Arg Leu Glu Val Ala Gly Pro 115 120 125 Arg Lys Gly Pro Leu Ser Pro Ala Trp Met Pro Ala Tyr Ala Cys Gln 130 135 140 Arg Pro Thr Pro Leu Thr His His Asn Thr Gly Leu Ser Glu Ala Leu 145 150 155 160 Glu Ile Leu Ala Glu Ala Ala Gly Phe Glu Gly Ser Glu Gly Arg Leu 165 170 175 Leu Thr Phe Cys Arg Ala Ala Ser Val Leu Lys Ala Leu Pro Ser Pro 180 185 190 Val Thr Thr Leu Ser Gln Leu Gln Gly Leu Pro His Phe Gly Glu His 195 200 205 Ser Ser Arg Val Val Gln Glu Leu Leu Glu His Gly Val Cys Glu Glu 210 215 220 Val Glu Arg Val Arg Arg Ser Glu Ser Ser Ser Pro Arg Ser Ser Gly 225 230 235 240 Ser Val <210> 960 <211> 122 <212> PRT <213> Homo sapiens <400> 960 Met Cys Tyr Phe Leu Ser Val Val Ser Leu Pro Val Ser Met Ala Thr 1 5 10 15 Phe Pro Leu Phe Leu Leu Thr Pro Gly Leu Ile Gly Lys Cys Arg Leu 20 25 30 Ser Ser Phe Gly Cys Leu Gly Cys Ala Cys Phe Asp Thr Leu Leu Pro 35 40 45 Thr Gly Phe Val Ala Gly Gly Val Thr Ala Val Ala Thr Trp Ile Thr 50 55 60 Val Ser Glu Val Trp Leu Pro Gly Trp Met Gly Pro Trp Glu Val Thr 65 70 75 80 Gln Asn Val Val Arg Ile Asp Arg Glu Gly Phe Glu Glu Glu Arg Leu 85 90 95 Glu Gln Cys Val Gln Gly Lys Trp Ala Gln Ile Cys Arg Glu Gly Gly 100 105 110 Lys Gly His Trp Gln Gly Gln Gly Thr Arg 115 120 <210> 961 <211> 282 <212> PRT <213> Homo sapiens <400> 961 Met Ala Leu Glu Ala Ala Gly Gly Pro Pro Glu Glu Thr Leu Ser Leu 1 5 10 15 Trp Lys Arg Glu Gln Ala Arg Leu Lys Ala His Val Val Asp Arg Asp 20 25 30 Thr Glu Ala Trp Gln Arg Asp Pro Ala Phe Ser Gly Leu Gln Arg Val 35 40 45 Gly Gly Val Asp Val Ser Phe Val Lys Gly Asp Ser Val Arg Ala Cys 50 55 60 Ala Ser Leu Val Val Leu Ser Phe Pro Glu Leu Glu Val Val Tyr Glu 65 70 75 80 Glu Ser Arg Met Val Ser Leu Thr Ala Pro Tyr Val Ser Gly Phe Leu 85 90 95 Ala Phe Arg Glu Val Pro Phe Leu Leu Glu Leu Val Gln Gln Leu Arg 100 105 110 Glu Lys Glu Pro Gly Leu Met Pro Gln Val Leu Leu Val Asp Gly Asn 115 120 125 Gly Val Leu His His Arg Gly Phe Gly Val Ala Cys His Leu Gly Val 130 135 140 Leu Thr Asp Leu Pro Cys Val Gly Val Ala Lys Lys Leu Leu Gln Val 145 150 155 160 Asp Gly Leu Glu Asn Asn Ala Leu His Lys Glu Lys Ile Arg Leu Leu 165 170 175 Gln Thr Arg Gly Asp Ser Phe Pro Leu Leu Gly Asp Ser Gly Thr Val 180 185 190 Leu Gly Met Ala Leu Arg Ser His Asp Arg Ser Thr Arg Pro Leu Tyr 195 200 205 Ile Ser Val Gly His Arg Met Ser Leu Glu Ala Ala Val Arg Leu Thr 210 215 220 Cys Cys Cys Cys Arg Phe Arg Ile Pro Glu Pro Val Arg Gln Ala Asp 225 230 235 240 Ile Cys Ser Arg Glu His Ile Arg Lys Ser Leu Gly Leu Pro Gly Pro 245 250 255 Pro Thr Pro Arg Ser Pro Lys Ala Gln Arg Pro Val Ala Cys Pro Lys 260 265 270 Gly Asp Ser Gly Glu Ser Ser Ala Leu Cys 275 280 <210> 962 <211> 282 <212> PRT <213> Homo sapiens <400> 962 Met Ala Leu Glu Ala Ala Gly Gly Pro Pro Glu Glu Thr Leu Ser Leu 1 5 10 15 Trp Lys Arg Glu Gln Ala Arg Leu Lys Ala His Val Val Asp Arg Asp 20 25 30 Thr Glu Ala Trp Gln Arg Asp Pro Ala Phe Ser Gly Leu Gln Arg Val 35 40 45 Gly Gly Val Asp Val Ser Phe Val Lys Gly Asp Ser Val Arg Ala Cys 50 55 60 Ala Ser Leu Val Val Leu Ser Phe Pro Glu Leu Glu Val Val Tyr Glu 65 70 75 80 Glu Ser Arg Met Val Ser Leu Thr Ala Pro Tyr Val Ser Gly Phe Leu 85 90 95 Ala Phe Arg Glu Val Pro Phe Leu Leu Glu Leu Val Gln Gln Leu Arg 100 105 110 Glu Lys Glu Pro Gly Leu Met Pro Gln Val Leu Leu Val Asp Gly Asn 115 120 125 Gly Val Leu His His Arg Gly Phe Gly Val Ala Cys His Leu Gly Val 130 135 140 Leu Thr Asp Leu Pro Cys Val Gly Val Ala Lys Lys Leu Leu Gln Val 145 150 155 160 Asp Gly Leu Glu Asn Asn Ala Leu His Lys Glu Lys Ile Arg Leu Leu 165 170 175 Gln Thr Arg Gly Asp Ser Phe Pro Leu Leu Gly Asp Ser Gly Thr Val 180 185 190 Leu Gly Met Ala Leu Arg Ser His Asp Arg Ser Thr Arg Pro Leu Tyr 195 200 205 Ile Ser Val Gly His Arg Met Ser Leu Glu Ala Ala Val Arg Leu Thr 210 215 220 Cys Cys Cys Cys Arg Phe Arg Ile Pro Glu Pro Val Arg Gln Ala Asp 225 230 235 240 Ile Cys Ser Arg Glu His Ile Arg Lys Ser Leu Gly Leu Pro Gly Pro 245 250 255 Pro Thr Pro Arg Ser Pro Lys Ala Gln Arg Pro Val Ala Cys Pro Lys 260 265 270 Gly Asp Ser Gly Glu Ser Ser Ala Leu Cys 275 280 <210> 963 <211> 65 <212> PRT <213> Homo sapiens <400> 963 Met Ala Leu Arg Ser His Asp Arg Ser Thr Arg Pro Leu Tyr Ile Ser 1 5 10 15 Val Gly His Arg Met Ser Leu Glu Ala Ala Val Arg Leu Thr Cys Cys 20 25 30 Cys Cys Arg Phe Arg Ile Pro Glu Pro Val Arg Gln His Phe Val Glu 35 40 45 Arg Gly Gly Glu Ser Thr Arg Pro Arg Leu Ile Pro Asp Arg Thr Arg 50 55 60 Trp 65 <210> 964 <211> 160 <212> PRT <213> Homo sapiens <400> 964 Met Leu Ser His Leu Leu Ala Tyr Arg Arg Ser Arg Asp Phe Ile Asp 1 5 10 15 Val Cys Glu Val Ser Glu Asn Val Pro Ala Phe Thr Pro Ala Phe Ser 20 25 30 His Trp His Leu Leu Leu Thr Trp Ala Ile Trp Pro Cys Met Val Leu 35 40 45 Gly Glu Ser Ser Leu Thr Leu Gln Met Leu Ser Ser Asp Leu Ala Gly 50 55 60 Lys Gly Asp Gln Glu Cys Arg Ala Pro Ala Glu Asp Ser Pro Lys Pro 65 70 75 80 Lys Ser Gln Arg Val Gly Ala Pro Thr Thr Ser Ala Cys Met Pro Phe 85 90 95 Pro Gly Ser Pro Gln Ala Asp Ser Gln His Pro Leu Pro Lys Asp Arg 100 105 110 Ala Val Pro Asp Gln His Pro Thr Lys Ser Ser Val Arg Pro Val Phe 115 120 125 Gly Gly Ala Gly Phe Gln Glu Asp Ser Gly Gly Gly Val Glu Leu Met 130 135 140 Ala Gly Gly Ser Gly Pro Leu Arg Lys Leu Cys His Trp Ala Trp Gly 145 150 155 160 <210> 965 <211> 264 <212> PRT <213> Homo sapiens <400> 965 Met Ala Leu Glu Ala Ala Gly Gly Pro Pro Glu Glu Thr Leu Ser Leu 1 5 10 15 Trp Lys Arg Glu Gln Ala Arg Leu Lys Ala His Val Val Asp Arg Asp 20 25 30 Thr Glu Ala Trp Gln Arg Asp Pro Ala Phe Ser Gly Leu Gln Arg Val 35 40 45 Gly Gly Val Asp Val Ser Phe Val Lys Gly Asp Ser Val Arg Ala Cys 50 55 60 Ala Ser Leu Val Val Leu Ser Phe Pro Glu Leu Glu Val Leu Leu Val 65 70 75 80 Asp Gly Asn Gly Val Leu His His Arg Gly Phe Gly Val Ala Cys His 85 90 95 Leu Gly Val Leu Thr Asp Leu Pro Cys Val Gly Val Ala Lys Lys Leu 100 105 110 Leu Gln Val Asp Gly Leu Glu Asn Asn Ala Leu His Lys Glu Lys Ile 115 120 125 Arg Leu Leu Gln Thr Arg Gly Asp Ser Phe Pro Leu Leu Gly Asp Ser 130 135 140 Gly Thr Val Leu Gly Met Ala Leu Arg Ser His Asp Arg Ser Thr Arg 145 150 155 160 Pro Leu Tyr Ile Ser Val Gly His Arg Met Ser Leu Glu Ala Ala Val 165 170 175 Arg Leu Thr Cys Cys Cys Cys Arg Phe Arg Ile Pro Glu Pro Val Arg 180 185 190 Gln Ala Asp Ile Cys Ser Arg Glu His Ile Arg Lys Ser Leu Gly Leu 195 200 205 Pro Gly Pro Pro Thr Pro Arg Ser Pro Lys Ala Gln Arg Pro Val Ala 210 215 220 Cys Pro Lys Gly Asp Ser Gly Glu Ser Ser Gly Glu Gly Gln Pro Pro 225 230 235 240 Gln Asp His Ser Pro Gly Pro Arg Thr Ala Pro Arg Pro Gly Ser Gln 245 250 255 Glu Gln Ala Gly Lys Asp Trp Gln 260 <210> 966 <211> 282 <212> PRT <213> Homo sapiens <400> 966 Met Ala Leu Glu Ala Ala Gly Gly Pro Pro Glu Glu Thr Leu Ser Leu 1 5 10 15 Trp Lys Arg Glu Gln Ala Arg Leu Lys Ala His Val Val Asp Arg Asp 20 25 30 Thr Glu Ala Trp Gln Arg Asp Pro Ala Phe Ser Gly Leu Gln Arg Val 35 40 45 Gly Gly Val Asp Val Ser Phe Val Lys Gly Asp Ser Val Arg Ala Cys 50 55 60 Ala Ser Leu Val Val Leu Ser Phe Pro Glu Leu Glu Val Val Tyr Glu 65 70 75 80 Glu Ser Arg Met Val Ser Leu Thr Ala Pro Tyr Val Ser Gly Phe Leu 85 90 95 Ala Phe Arg Glu Val Pro Phe Leu Leu Glu Leu Val Gln Gln Leu Arg 100 105 110 Glu Lys Glu Pro Gly Leu Met Pro Gln Val Leu Leu Val Asp Gly Asn 115 120 125 Gly Val Leu His His Arg Gly Phe Gly Val Ala Cys His Leu Gly Val 130 135 140 Leu Thr Asp Leu Pro Cys Val Gly Val Ala Lys Lys Leu Leu Gln Val 145 150 155 160 Asp Gly Leu Glu Asn Asn Ala Leu His Lys Glu Lys Ile Arg Leu Leu 165 170 175 Gln Thr Arg Gly Asp Ser Phe Pro Leu Leu Gly Asp Ser Gly Thr Val 180 185 190 Leu Gly Met Ala Leu Arg Ser His Asp Arg Ser Thr Arg Pro Leu Tyr 195 200 205 Ile Ser Val Gly His Arg Met Ser Leu Glu Ala Ala Val Arg Leu Thr 210 215 220 Cys Cys Cys Cys Arg Phe Arg Ile Pro Glu Pro Val Arg Gln Ala Asp 225 230 235 240 Ile Cys Ser Arg Glu His Ile Arg Lys Ser Leu Gly Leu Pro Gly Pro 245 250 255 Pro Thr Pro Arg Ser Pro Lys Ala Gln Arg Pro Val Ala Cys Pro Lys 260 265 270 Gly Asp Ser Gly Glu Ser Ser Ala Leu Cys 275 280 <210> 967 <211> 237 <212> PRT <213> Homo sapiens <400> 967 Met Ala Leu Glu Ala Ala Gly Gly Pro Pro Glu Glu Thr Leu Ser Leu 1 5 10 15 Trp Lys Trp Glu Gln Ala Arg Leu Lys Ala His Val Val Asp Arg Asp 20 25 30 Thr Glu Ala Trp Gln Arg Asp Pro Ala Phe Ser Gly Leu Gln Arg Val 35 40 45 Gly Gly Val Asp Val Ser Phe Val Lys Gly Asp Ser Val Arg Ala Cys 50 55 60 Ala Ser Leu Val Val Leu Ser Phe Pro Glu Leu Glu Val Leu Leu Val 65 70 75 80 Asp Gly Asn Gly Val Leu His His Arg Gly Phe Gly Val Ala Cys His 85 90 95 Leu Gly Val Leu Thr Asp Leu Pro Cys Val Gly Val Ala Lys Lys Leu 100 105 110 Leu Gln Val Asp Gly Leu Glu Asn Asn Ala Leu His Lys Glu Lys Ile 115 120 125 Arg Leu Leu Gln Thr Arg Gly Asp Ser Phe Pro Leu Leu Gly Asp Ser 130 135 140 Gly Thr Val Leu Gly Met Ala Leu Arg Ser His Asp Arg Ser Thr Arg 145 150 155 160 Pro Leu Tyr Ile Ser Val Gly His Arg Met Ser Leu Glu Ala Ala Val 165 170 175 Arg Leu Thr Cys Cys Cys Cys Arg Phe Arg Ile Pro Glu Pro Val Arg 180 185 190 Gln Ala Asp Ile Cys Ser Arg Glu His Ile Arg Lys Ser Leu Gly Leu 195 200 205 Pro Gly Pro Pro Thr Pro Arg Ser Pro Lys Ala Gln Arg Pro Val Ala 210 215 220 Cys Pro Lys Gly Asp Ser Gly Glu Ser Ser Ala Leu Cys 225 230 235 <210> 968 <211> 65 <212> PRT <213> Homo sapiens <400> 968 Met Ala Leu Arg Ser His Asp Arg Ser Thr Arg Pro Leu Tyr Ile Ser 1 5 10 15 Val Gly His Arg Met Ser Leu Glu Ala Ala Val Arg Leu Thr Cys Cys 20 25 30 Cys Cys Arg Phe Arg Ile Pro Glu Pro Val Arg Gln His Phe Val Glu 35 40 45 Arg Gly Gly Glu Ser Thr Arg Pro Arg Leu Ile Pro Asp Arg Thr Arg 50 55 60 Trp 65 <210> 969 <211> 642 <212> PRT <213> Homo sapiens <400> 969 Met Lys Arg Ser Ser Val Ser Ser Gly Gly Ala Gly Arg Leu Ser Met 1 5 10 15 Gln Glu Leu Arg Ser Gln Asp Val Asn Lys Gln Gly Leu Tyr Thr Pro 20 25 30 Gln Thr Lys Glu Lys Pro Thr Phe Gly Lys Leu Ser Ile Asn Lys Pro 35 40 45 Thr Ser Glu Arg Lys Val Ser Leu Phe Gly Lys Arg Thr Ser Gly His 50 55 60 Gly Ser Arg Asn Ser Gln Leu Gly Ile Phe Ser Ser Ser Glu Lys Ile 65 70 75 80 Lys Asp Pro Arg Pro Leu Asn Asp Lys Ala Phe Ile Gln Gln Cys Ile 85 90 95 Arg Gln Leu Cys Glu Phe Leu Thr Glu Asn Gly Tyr Ala His Asn Val 100 105 110 Ser Met Lys Ser Leu Gln Ala Pro Ser Val Lys Asp Phe Leu Lys Ile 115 120 125 Phe Thr Phe Leu Tyr Gly Phe Leu Cys Pro Ser Tyr Glu Leu Pro Asp 130 135 140 Thr Lys Phe Glu Glu Glu Val Pro Arg Ile Phe Lys Asp Leu Gly Tyr 145 150 155 160 Pro Phe Ala Leu Ser Lys Ser Ser Met Tyr Thr Val Gly Ala Pro His 165 170 175 Thr Trp Pro His Ile Val Ala Ala Leu Val Trp Leu Ile Asp Cys Ile 180 185 190 Lys Ile His Thr Ala Met Lys Glu Ser Ser Pro Leu Phe Asp Asp Gly 195 200 205 Gln Pro Trp Gly Glu Glu Thr Glu Asp Gly Ile Met His Asn Lys Leu 210 215 220 Phe Leu Asp Tyr Thr Ile Lys Cys Tyr Glu Ser Phe Met Ser Gly Ala 225 230 235 240 Asp Ser Phe Asp Glu Met Asn Ala Glu Leu Gln Ser Lys Leu Lys Asp 245 250 255 Leu Phe Asn Val Asp Ala Phe Lys Leu Glu Ser Leu Glu Ala Lys Asn 260 265 270 Arg Ala Leu Asn Glu Gln Ile Ala Arg Leu Glu Gln Glu Arg Glu Lys 275 280 285 Glu Pro Asn Arg Leu Glu Ser Leu Arg Lys Leu Lys Ala Ser Leu Gln 290 295 300 Gly Asp Val Gln Lys Tyr Gln Ala Tyr Met Ser Asn Leu Glu Ser His 305 310 315 320 Ser Ala Ile Leu Asp Gln Lys Leu Asn Gly Leu Asn Glu Glu Ile Ala 325 330 335 Arg Val Glu Leu Glu Cys Glu Thr Ile Lys Gln Glu Asn Thr Arg Leu 340 345 350 Gln Asn Ile Ile Asp Asn Gln Lys Tyr Ser Val Ala Asp Ile Glu Arg 355 360 365 Ile Asn His Glu Arg Asn Glu Leu Gln Gln Thr Ile Asn Lys Leu Thr 370 375 380 Lys Asp Leu Glu Ala Glu Gln Gln Lys Leu Trp Asn Glu Glu Leu Lys 385 390 395 400 Tyr Ala Arg Gly Lys Glu Ala Ile Glu Thr Gln Leu Ala Glu Tyr His 405 410 415 Lys Leu Ala Arg Lys Leu Lys Leu Ile Pro Lys Gly Ala Glu Asn Ser 420 425 430 Lys Gly Tyr Asp Phe Glu Ile Lys Phe Asn Pro Glu Ala Gly Ala Asn 435 440 445 Cys Leu Val Lys Tyr Arg Ala Gln Val Tyr Val Pro Leu Lys Glu Leu 450 455 460 Leu Asn Glu Thr Glu Glu Glu Ile Asn Lys Ala Leu Asn Lys Lys Met 465 470 475 480 Gly Leu Glu Asp Thr Leu Glu Gln Leu Asn Ala Met Ile Thr Glu Ser 485 490 495 Lys Arg Ser Val Arg Thr Leu Lys Glu Glu Val Gln Lys Leu Asp Asp 500 505 510 Leu Tyr Gln Gln Lys Ile Lys Glu Ala Glu Glu Glu Asp Glu Lys Cys 515 520 525 Ala Ser Glu Leu Glu Ser Leu Glu Lys His Lys His Leu Leu Glu Ser 530 535 540 Thr Val Asn Gln Gly Leu Ser Glu Ala Met Asn Glu Leu Asp Ala Val 545 550 555 560 Gln Arg Glu Tyr Gln Leu Val Val Gln Thr Thr Thr Glu Glu Arg Arg 565 570 575 Lys Val Gly Asn Asn Leu Gln Arg Leu Leu Glu Met Val Ala Thr His 580 585 590 Val Gly Ser Val Glu Lys His Leu Glu Glu Gln Ile Ala Lys Val Asp 595 600 605 Arg Glu Tyr Glu Glu Cys Met Ser Glu Asp Leu Ser Glu Asn Ile Lys 610 615 620 Glu Ile Arg Asp Lys Tyr Glu Lys Lys Ala Thr Leu Ile Lys Ser Ser 625 630 635 640 Glu Glu <210> 970 <211> 642 <212> PRT <213> Homo sapiens <400> 970 Met Lys Arg Ser Ser Val Ser Ser Gly Gly Ala Gly Arg Leu Ser Met 1 5 10 15 Gln Glu Leu Arg Ser Gln Asp Val Asn Lys Gln Gly Leu Tyr Thr Pro 20 25 30 Gln Thr Lys Glu Lys Pro Thr Phe Gly Lys Leu Ser Ile Asn Lys Pro 35 40 45 Thr Ser Glu Arg Lys Val Ser Leu Phe Gly Lys Arg Thr Ser Gly His 50 55 60 Gly Ser Arg Asn Ser Gln Leu Gly Ile Phe Ser Ser Ser Glu Lys Ile 65 70 75 80 Lys Asp Pro Arg Pro Leu Asn Asp Lys Ala Phe Ile Gln Gln Cys Ile 85 90 95 Arg Gln Leu Cys Glu Phe Leu Thr Glu Asn Gly Tyr Ala His Asn Val 100 105 110 Ser Met Lys Ser Leu Gln Ala Pro Ser Val Lys Asp Phe Leu Lys Ile 115 120 125 Phe Thr Phe Leu Tyr Gly Phe Leu Cys Pro Ser Tyr Glu Leu Pro Asp 130 135 140 Thr Lys Phe Glu Glu Glu Val Pro Arg Ile Phe Lys Asp Leu Gly Tyr 145 150 155 160 Pro Phe Ala Leu Ser Lys Ser Ser Met Tyr Thr Val Gly Ala Pro His 165 170 175 Thr Trp Pro His Ile Val Ala Ala Leu Val Trp Leu Ile Asp Cys Ile 180 185 190 Lys Ile His Thr Ala Met Lys Glu Ser Ser Pro Leu Phe Asp Asp Gly 195 200 205 Gln Pro Trp Gly Glu Glu Thr Glu Asp Gly Ile Met His Asn Lys Leu 210 215 220 Phe Leu Asp Tyr Thr Ile Lys Cys Tyr Glu Ser Phe Met Ser Gly Ala 225 230 235 240 Asp Ser Phe Asp Glu Met Asn Ala Glu Leu Gln Ser Lys Leu Lys Asp 245 250 255 Leu Phe Asn Val Asp Ala Phe Lys Leu Glu Ser Leu Glu Ala Lys Asn 260 265 270 Arg Ala Leu Asn Glu Gln Ile Ala Arg Leu Glu Gln Glu Arg Glu Lys 275 280 285 Glu Pro Asn Arg Leu Glu Ser Leu Arg Lys Leu Lys Ala Ser Leu Gln 290 295 300 Gly Asp Val Gln Lys Tyr Gln Ala Tyr Met Ser Asn Leu Glu Ser His 305 310 315 320 Ser Ala Ile Leu Asp Gln Lys Leu Asn Gly Leu Asn Glu Glu Ile Ala 325 330 335 Arg Val Glu Leu Glu Cys Glu Thr Ile Lys Gln Glu Asn Thr Arg Leu 340 345 350 Gln Asn Ile Ile Asp Asn Gln Lys Tyr Ser Val Ala Asp Ile Glu Arg 355 360 365 Ile Asn His Glu Arg Asn Glu Leu Gln Gln Thr Ile Asn Lys Leu Thr 370 375 380 Lys Asp Leu Glu Ala Glu Gln Gln Lys Leu Trp Asn Glu Glu Leu Lys 385 390 395 400 Tyr Ala Arg Gly Lys Glu Ala Ile Glu Thr Gln Leu Ala Glu Tyr His 405 410 415 Lys Leu Ala Arg Lys Leu Lys Leu Ile Pro Lys Gly Ala Glu Asn Ser 420 425 430 Lys Gly Tyr Asp Phe Glu Ile Lys Phe Asn Pro Glu Ala Gly Ala Asn 435 440 445 Cys Leu Val Lys Tyr Arg Ala Gln Val Tyr Val Pro Leu Lys Glu Leu 450 455 460 Leu Asn Glu Thr Glu Glu Glu Ile Asn Lys Ala Leu Asn Lys Lys Met 465 470 475 480 Gly Leu Glu Asp Thr Leu Glu Gln Leu Asn Ala Met Ile Thr Glu Ser 485 490 495 Lys Arg Ser Val Arg Thr Leu Lys Glu Glu Val Gln Lys Leu Asp Asp 500 505 510 Leu Tyr Gln Gln Lys Ile Lys Glu Ala Glu Glu Glu Asp Glu Lys Cys 515 520 525 Ala Ser Glu Leu Glu Ser Leu Glu Lys His Lys His Leu Leu Glu Ser 530 535 540 Thr Val Asn Gln Gly Leu Ser Glu Ala Met Asn Glu Leu Asp Ala Val 545 550 555 560 Gln Arg Glu Tyr Gln Leu Val Val Gln Thr Thr Thr Glu Glu Arg Arg 565 570 575 Lys Val Gly Asn Asn Leu Gln Arg Leu Leu Glu Met Val Ala Thr His 580 585 590 Val Gly Ser Val Glu Lys His Leu Glu Glu Gln Ile Ala Lys Val Asp 595 600 605 Arg Glu Tyr Glu Glu Cys Met Ser Glu Asp Leu Ser Glu Asn Ile Lys 610 615 620 Glu Ile Arg Asp Lys Tyr Glu Lys Lys Ala Thr Leu Ile Lys Ser Ser 625 630 635 640 Glu Glu <210> 971 <211> 97 <212> PRT <213> Homo sapiens <400> 971 Met Lys Arg Ser Ser Val Ser Ser Gly Gly Ala Gly Arg Leu Ser Met 1 5 10 15 Gln Glu Leu Arg Ser Gln Asp Val Asn Lys Gln Gly Leu Tyr Thr Pro 20 25 30 Gln Thr Lys Glu Lys Pro Thr Phe Gly Lys Leu Ser Ile Asn Lys Pro 35 40 45 Thr Ser Glu Arg Lys Val Ser Leu Phe Gly Lys Arg Thr Ser Gly His 50 55 60 Gly Ser Arg Asn Ser Gln Leu Gly Ile Phe Ser Ser Ser Glu Lys Ile 65 70 75 80 Lys Asp Pro Arg Pro Leu Asn Asp Lys Ala Phe Ile Gln Gln Cys Ile 85 90 95 Arg <210> 972 <211> 642 <212> PRT <213> Homo sapiens <400> 972 Met Lys Arg Ser Ser Val Ser Ser Gly Gly Ala Gly Arg Leu Ser Met 1 5 10 15 Gln Glu Leu Arg Ser Gln Asp Val Asn Lys Gln Gly Leu Tyr Thr Pro 20 25 30 Gln Thr Lys Glu Lys Pro Thr Phe Gly Lys Leu Ser Ile Asn Lys Pro 35 40 45 Thr Ser Glu Arg Lys Val Ser Leu Phe Gly Lys Arg Thr Ser Gly His 50 55 60 Gly Ser Arg Asn Ser Gln Leu Gly Ile Phe Ser Ser Ser Glu Lys Ile 65 70 75 80 Lys Asp Pro Arg Pro Leu Asn Asp Lys Ala Phe Ile Gln Gln Cys Ile 85 90 95 Arg Gln Leu Cys Glu Phe Leu Thr Glu Asn Gly Tyr Ala His Asn Val 100 105 110 Ser Met Lys Ser Leu Gln Ala Pro Ser Val Lys Asp Phe Leu Lys Ile 115 120 125 Phe Thr Phe Leu Tyr Gly Phe Leu Cys Pro Ser Tyr Glu Leu Pro Asp 130 135 140 Thr Lys Phe Glu Glu Glu Val Pro Arg Ile Phe Lys Asp Leu Gly Tyr 145 150 155 160 Pro Phe Ala Leu Ser Lys Ser Ser Met Tyr Thr Val Gly Ala Pro His 165 170 175 Thr Trp Pro His Ile Val Ala Ala Leu Val Trp Leu Ile Asp Cys Ile 180 185 190 Lys Ile His Thr Ala Met Lys Glu Ser Ser Pro Leu Phe Asp Asp Gly 195 200 205 Gln Pro Trp Gly Glu Glu Thr Glu Asp Gly Ile Met His Asn Lys Leu 210 215 220 Phe Leu Asp Tyr Thr Ile Lys Cys Tyr Glu Ser Phe Met Ser Gly Ala 225 230 235 240 Asp Ser Phe Asp Glu Met Asn Ala Glu Leu Gln Ser Lys Leu Lys Asp 245 250 255 Leu Phe Asn Val Asp Ala Phe Lys Leu Glu Ser Leu Glu Ala Lys Asn 260 265 270 Arg Ala Leu Asn Glu Gln Ile Ala Arg Leu Glu Gln Glu Arg Glu Lys 275 280 285 Glu Pro Asn Arg Leu Glu Ser Leu Arg Lys Leu Lys Ala Ser Leu Gln 290 295 300 Gly Asp Val Gln Lys Tyr Gln Ala Tyr Met Ser Asn Leu Glu Ser His 305 310 315 320 Ser Ala Ile Leu Asp Gln Lys Leu Asn Gly Leu Asn Glu Glu Ile Ala 325 330 335 Arg Val Glu Leu Glu Cys Glu Thr Ile Lys Gln Glu Asn Thr Arg Leu 340 345 350 Gln Asn Ile Ile Asp Asn Gln Lys Tyr Ser Val Ala Asp Ile Glu Arg 355 360 365 Ile Asn His Glu Arg Asn Glu Leu Gln Gln Thr Ile Asn Lys Leu Thr 370 375 380 Lys Asp Leu Glu Ala Glu Gln Gln Lys Leu Trp Asn Glu Glu Leu Lys 385 390 395 400 Tyr Ala Arg Gly Lys Glu Ala Ile Glu Thr Gln Leu Ala Glu Tyr His 405 410 415 Lys Leu Ala Arg Lys Leu Lys Leu Ile Pro Lys Gly Ala Glu Asn Ser 420 425 430 Lys Gly Tyr Asp Phe Glu Ile Lys Phe Asn Pro Glu Ala Gly Ala Asn 435 440 445 Cys Leu Val Lys Tyr Arg Ala Gln Val Tyr Val Pro Leu Lys Glu Leu 450 455 460 Leu Asn Glu Thr Glu Glu Glu Ile Asn Lys Ala Leu Asn Lys Lys Met 465 470 475 480 Gly Leu Glu Asp Thr Leu Glu Gln Leu Asn Ala Met Ile Thr Glu Ser 485 490 495 Lys Arg Ser Val Arg Thr Leu Lys Glu Glu Val Gln Lys Leu Asp Asp 500 505 510 Leu Tyr Gln Gln Lys Ile Lys Glu Ala Glu Glu Glu Asp Glu Lys Cys 515 520 525 Ala Ser Glu Leu Glu Ser Leu Glu Lys His Lys His Leu Leu Glu Ser 530 535 540 Thr Val Asn Gln Gly Leu Ser Glu Ala Met Asn Glu Leu Asp Ala Val 545 550 555 560 Gln Arg Glu Tyr Gln Leu Val Val Gln Thr Thr Thr Glu Glu Arg Arg 565 570 575 Lys Val Gly Asn Asn Leu Gln Arg Leu Leu Glu Met Val Ala Thr His 580 585 590 Val Gly Ser Val Glu Lys His Leu Glu Glu Gln Ile Ala Lys Val Asp 595 600 605 Arg Glu Tyr Glu Glu Cys Met Ser Glu Asp Leu Ser Glu Asn Ile Lys 610 615 620 Glu Ile Arg Asp Lys Tyr Glu Lys Lys Ala Thr Leu Ile Lys Ser Ser 625 630 635 640 Glu Glu <210> 973 <211> 642 <212> PRT <213> Homo sapiens <400> 973 Met Lys Arg Ser Ser Val Ser Ser Gly Gly Ala Gly Arg Leu Ser Met 1 5 10 15 Gln Glu Leu Arg Ser Gln Asp Val Asn Lys Gln Gly Leu Tyr Thr Pro 20 25 30 Gln Thr Lys Glu Lys Pro Thr Phe Gly Lys Leu Ser Ile Asn Lys Pro 35 40 45 Thr Ser Glu Arg Lys Val Ser Leu Phe Gly Lys Arg Thr Ser Gly His 50 55 60 Gly Ser Arg Asn Ser Gln Leu Gly Ile Phe Ser Ser Ser Glu Lys Ile 65 70 75 80 Lys Asp Pro Arg Pro Leu Asn Asp Lys Ala Phe Ile Gln Gln Cys Ile 85 90 95 Arg Gln Leu Cys Glu Phe Leu Thr Glu Asn Gly Tyr Ala His Asn Val 100 105 110 Ser Met Lys Ser Leu Gln Ala Pro Ser Val Lys Asp Phe Leu Lys Ile 115 120 125 Phe Thr Phe Leu Tyr Gly Phe Leu Cys Pro Ser Tyr Glu Leu Pro Asp 130 135 140 Thr Lys Phe Glu Glu Glu Val Pro Arg Ile Phe Lys Asp Leu Gly Tyr 145 150 155 160 Pro Phe Ala Leu Ser Lys Ser Ser Met Tyr Thr Val Gly Ala Pro His 165 170 175 Thr Trp Pro His Ile Val Ala Ala Leu Val Trp Leu Ile Asp Cys Ile 180 185 190 Lys Ile His Thr Ala Met Lys Glu Ser Ser Pro Leu Phe Asp Asp Gly 195 200 205 Gln Pro Trp Gly Glu Glu Thr Glu Asp Gly Ile Met His Asn Lys Leu 210 215 220 Phe Leu Asp Tyr Thr Ile Lys Cys Tyr Glu Ser Phe Met Ser Gly Ala 225 230 235 240 Asp Ser Phe Asp Glu Met Asn Ala Glu Leu Gln Ser Lys Leu Lys Asp 245 250 255 Leu Phe Asn Val Asp Ala Phe Lys Leu Glu Ser Leu Glu Ala Lys Asn 260 265 270 Arg Ala Leu Asn Glu Gln Ile Ala Arg Leu Glu Gln Glu Arg Glu Lys 275 280 285 Glu Pro Asn Arg Leu Glu Ser Leu Arg Lys Leu Lys Ala Ser Leu Gln 290 295 300 Gly Asp Val Gln Lys Tyr Gln Ala Tyr Met Ser Asn Leu Glu Ser His 305 310 315 320 Ser Ala Ile Leu Asp Gln Lys Leu Asn Gly Leu Asn Glu Glu Ile Ala 325 330 335 Arg Val Glu Leu Glu Cys Glu Thr Ile Lys Gln Glu Asn Thr Arg Leu 340 345 350 Gln Asn Ile Ile Asp Asn Gln Lys Tyr Ser Val Ala Asp Ile Glu Arg 355 360 365 Ile Asn His Glu Arg Asn Glu Leu Gln Gln Thr Ile Asn Lys Leu Thr 370 375 380 Lys Asp Leu Glu Ala Glu Gln Gln Lys Leu Trp Asn Glu Glu Leu Lys 385 390 395 400 Tyr Ala Arg Gly Lys Glu Ala Ile Glu Thr Gln Leu Ala Glu Tyr His 405 410 415 Lys Leu Ala Arg Lys Leu Lys Leu Ile Pro Lys Gly Ala Glu Asn Ser 420 425 430 Lys Gly Tyr Asp Phe Glu Ile Lys Phe Asn Pro Glu Ala Gly Ala Asn 435 440 445 Cys Leu Val Lys Tyr Arg Ala Gln Val Tyr Val Pro Leu Lys Glu Leu 450 455 460 Leu Asn Glu Thr Glu Glu Glu Ile Asn Lys Ala Leu Asn Lys Lys Met 465 470 475 480 Gly Leu Glu Asp Thr Leu Glu Gln Leu Asn Ala Met Ile Thr Glu Ser 485 490 495 Lys Arg Ser Val Arg Thr Leu Lys Glu Glu Val Gln Lys Leu Asp Asp 500 505 510 Leu Tyr Gln Gln Lys Ile Lys Glu Ala Glu Glu Glu Asp Glu Lys Cys 515 520 525 Ala Ser Glu Leu Glu Ser Leu Glu Lys His Lys His Leu Leu Glu Ser 530 535 540 Thr Val Asn Gln Gly Leu Ser Glu Ala Met Asn Glu Leu Asp Ala Val 545 550 555 560 Gln Arg Glu Tyr Gln Leu Val Val Gln Thr Thr Thr Glu Glu Arg Arg 565 570 575 Lys Val Gly Asn Asn Leu Gln Arg Leu Leu Glu Met Val Ala Thr His 580 585 590 Val Gly Ser Val Glu Lys His Leu Glu Glu Gln Ile Ala Lys Val Asp 595 600 605 Arg Glu Tyr Glu Glu Cys Met Ser Glu Asp Leu Ser Glu Asn Ile Lys 610 615 620 Glu Ile Arg Asp Lys Tyr Glu Lys Lys Ala Thr Leu Ile Lys Ser Ser 625 630 635 640 Glu Glu <210> 974 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 974 ggccagagca ucuucuuca 19 <210> 975 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 975 gagcuggaag aggugugug 19 <210> 976 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 976 ggcaugaccc uggauugug 19 <210> 977 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 977 aauugugcag agcuggaaa 19 <210> 978 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 978 aagaagcucc gagaugaaa 19 <210> 979 <211> 20 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 979 gggaaagaga agauuguagu 20 <210> 980 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 980 gaugguaucg uagaauuca 19 <210> 981 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 981 ggcaucgacu cuuuaacca 19 <210> 982 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 982 gcuggcuucu cgaaaguug 19 <210> 983 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 983 ccaucaagaa uaaggccca 19 <210> 984 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 984 aggccugagc uugcugaau 19 <210> 985 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 985 caccaacacu caggucauu 19 <210> 986 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 986 gacacugcug agcaccauu 19 <210> 987 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 987 gccacggaua gguccauau 19 <210> 988 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 988 gcgauguuuu gauauugaa 19 <210> 989 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 989 aaagagaaca gcagcugua 19 <210> 990 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 990 aagccaaaau acaggaagg 19 <210> 991 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 991 gcugucagau aguugauuu 19 <210> 992 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 992 gcucugcucu ggaugcuau 19 <210> 993 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 993 guuuguagca gcacggaua 19 <210> 994 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 994 ugaagaaacc aaagcaguu 19 <210> 995 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 995 gaugaagaaa ccaaagcag 19 <210> 996 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 996 ggguguuugu gccucauaa 19 <210> 997 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 997 gcagaaaauu caugcugau 19 <210> 998 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 998 ugcggaagcu ggaccauau 19 <210> 999 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 999 gggcaugagu cugucagaa 19 <210> 1000 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1000 aggcaaaaga ggcaccaaa 19 <210> 1001 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1001 gagagaaguu ucugcauuu 19 <210> 1002 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1002 cuggacauaa gcugguuaa 19 <210> 1003 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1003 cccgucgcag agcccuuua 19 <210> 1004 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1004 uguggaugga aacggggua 19 <210> 1005 <211> 25 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1005 aaucaaggac ccgagaccac uuaau 25 <210> 1006 <211> 25 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1006 ccagaaguac ucaguugcag acauu 25 <210> 1007 <211> 25 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1007 agaaguucaa aagcuggaug aucuu 25 <210> 1008 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1008 ggaguuaaga ucccaggau 19 <210> 1009 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1009 ccacuuaaug acaaagcau 19 <210> 1010 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1010 gcagccuuag uuuggcuaa 19 <210> 1011 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1011 ggaaauugcu agaguagaa 19 <210> 1012 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1012 gcuagaguag aacuagaau 19 <210> 1013 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1013 gcagacauug agcgaauaa 19 <210> 1014 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1014 ggaggauacu uuagaacaa 19 <210> 1015 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1015 ccagugagcu ugaguccuu 19 <210> 1016 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1016 gcuugagucc uuggagaaa 19 <210> 1017 <211> 18 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1017 ggagcagauu gcuaaagu 18 <210> 1018 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1018 gcuucugaac aaugccuuu 19 <210> 1019 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1019 ggacgucauu cuggaugau 19 <210> 1020 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1020 gcuucugcgg uaugugcuu 19 <210> 1021 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1021 gcagguauga ccaguauaa 19 <210> 1022 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1022 gcaugacaac cuucuacau 19 <210> 1023 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1023 gcaagaugca ggaugacaa 19 <210> 1024 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1024 ggaagaagca agacgucuu 19 <210> 1025 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1025 ggaguggaac aacucccaa 19 <210> 1026 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1026 ccucuucgag acaaguuaa 19 <210> 1027 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1027 gccaagacca ucagaagua 19 <210> 1028 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1028 gcuucauuau gaccuucua 19 <210> 1029 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1029 ccuucuacau cacccuuau 19 <210> 1030 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1030 ccaauaauuc agagcacau 19 <210> 1031 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1031 ggaagaaugc uacagucaa 19 <210> 1032 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1032 ggacagaauu gaaucacuu 19 <210> 1033 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1033 gcucaugaaa caguugaau 19 <210> 1034 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1034 ccacauccug ugcuaacaa 19 <210> 1035 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1035 gggagcagaa aggcaagaa 19 <210> 1036 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1036 ugcgcucagc agggaaaaa 19 <210> 1037 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1037 gaggagagac uuggauaau 19 <210> 1038 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1038 ggccuuggug aaggcagau 19 <210> 1039 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1039 ccgggauaag cagagaucu 19 <210> 1040 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1040 agaggagaga cuuggauaa 19 <210> 1041 <211> 18 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1041 ugcaaggucu uccacuau 18 <210> 1042 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1042 aggccucagc uuugaagaa 19 <210> 1043 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1043 gagcagagau gaagaaagu 19 <210> 1044 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1044 gcgggaugau gguguguau 19 <210> 1045 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1045 gcugucagau aguugauuu 19 <210> 1046 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1046 gcuucuuaca ccaguaauu 19 <210> 1047 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1047 gcucugcucu ggaugcuau 19 <210> 1048 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1048 gcucucauag acucccaua 19 <210> 1049 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1049 gcugaugggc agugacauu 19 <210> 1050 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1050 ggaugagauc uuggcucaa 19 <210> 1051 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1051 gccaagaagg uggcaucaa 19 <210> 1052 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1052 gccugacagu accaagcaa 19 <210> 1053 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1053 gcaucgugcu caaguacau 19 <210> 1054 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1054 ggaccuuguc uucgaggaa 19 <210> 1055 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1055 ggaaaucaug cggaaccaa 19 <210> 1056 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1056 ggaaccaauu cucugucaa 19 <210> 1057 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1057 ccucgucugu ggcuagauu 19 <210> 1058 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1058 gggacuucac acagguguu 19 <210> 1059 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1059 ccaccaaggu gaacuucaa 19 <210> 1060 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1060 gccgaguacu uugaugguu 19 <210> 1061 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1061 cccagcagua ugacauguu 19 <210> 1062 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1062 gcaucuacca gaaggccau 19 <210> 1063 <211> 19 <212> RNA <213> Artificial <220> <223> an artificially synthesized sequence <400> 1063 gcagacgugg aaggacuuu 19

Claims (17)

  1. 염색체의 안정화를 저해하는 화합물을 포함하는 암세포 특이적 아포토시스 유도제.
  2. 제1항에 있어서,
    염색체 안정화의 저해가 이하의 (a)~(r)의 어느 하나의 기능을 저해하는 것에 의한 아포토시스 유도제:
    (a) 인간 염색체 불안정성 질환 관련 유전자,
    (b) 염색체 DNA의 복제 개시 및 복제 포크의 진행을 포함하는 염색체 DNA 복제반응,
    (c) DNA 손상 체크 포인트,
    (d) 자매 염색분체 응집·분리,
    (e) 염기 제거 수복,
    (f) 미스매치 제거 수복,
    (g) 뉴클레오티드 제거 수복,
    (h) 상동 재조합 수복,
    (i) 비상동 말단 결합 수복(비상동 재조합 수복),
    (j) 이중쇄 DNA 절단 수복,
    (k) DNA 복제 후 수복(DNA 손상 내성),
    (l) DNA 가교 손상 수복,
    (m) DNA-단백질 가교 손상 수복,
    (n) DNA 폴리머라아제,
    (o) 뉴클레아제,
    (p) 뉴클레오티드 정화,
    (q) 염색질 구조 유지, 및
    (r) 텔로미어 구조 유지.
  3. 제2항의 (a)~(r)의 어느 하나의 기능에 관여하는 유전자의 발현을 저해하는 화합물을 포함하는 암세포 특이적 아포토시스 유도제.
  4. 이하의 어느 하나의 유전자의 발현을 억제하는 화합물을 유효성분으로서 함유하는 암세포 특이적 아포토시스 유도제:
    APE2, ATR, BRCA1, Chk1, Cdc5, Cdc6, Cdc7, Cdc45, Cdt1, CSA, CSB, Ctf18, DDB1, DDB2, DNA2, DUT, Elg1, EndoV, Esp1, Exonuclease1, FBH1, FEN1, Geminin, Hus1, KNTC2(NDC80), Ku80, Ligase1, Mad2, MBD4, Mcm3, Mcm4, Mcm5, Mcm6, Mcm7, Mcm8, Mcm10, MGMT, MLH3, Mms4, MPG, MSH2, Mus81, NBS1, NEIL2, NEIL3, NTH1, Orc1, Orc3, PARP1, PCNA, Pif1, PMS1, PMS2, PNK, Pola p180, Pola p70, Pola Spp1(Prim2a), Polb, Pold p125, Pole Dpb3, Pole Dpb4, Pole Pol2, Poli, Poll, Polm, Psf1, Psf2, Psf3, Rad1, Rad18, Rad23A, Rad23B, Rad51, Rad51D, Rad54, Rad6A, RPA34, RPA70, Scc1, Scc3, Sir2, SIRT1(Sirtuin), TDG, TDP1, TIMELESS, Tin2, Topoisomerase I, Topoisomerase IIIa, Topoisomerase IIIb, Ubc13, UNG, XAB2, XPC, XPF, XPG, Xrcc2, XRCC4.
  5. 제4항에 있어서,
    제4항에 기재된 각 유전자의 염기배열이 배열번호: 1~637, 810~908에 기재된 염기배열로 이루어지는 군에서 선택되는 아포토시스 유도제.
  6. 제4항에 있어서,
    제4항에 기재된 어느 하나의 유전자의 발현을 억제하는 화합물이 당해 유전자에 대해 RNAi 효과를 갖는 이중쇄(double-strand) RNA인 아포토시스 유도제.
  7. 제6항에 있어서,
    이중쇄 RNA가, 제4항에 기재된 어느 하나의 유전자의 mRNA에서의 연속하는 임의의 20~30 염기와 상동인 배열로 이루어지는 센스 RNA 및 당해 센스 RNA에 상보적인 배열로 이루어지는 안티센스 RNA로 이루어지는 이중쇄 RNA인 아포토시스 유도제.
  8. 제4항에 기재된 어느 하나의 유전자에 대해 RNAi 효과를 갖는 이중쇄 RNA를 발현할 수 있는 DNA를 유효성분으로서 함유하는 암세포 특이적 아포토시스 유도제.
  9. 제4항에 있어서,
    제4항에 기재된 어느 하나의 유전자의 발현을 억제하는 화합물이 이하의 (a) 또는 (b)인 아포토시스 유도제:
    (a) 상기 유전자의 전사 산물 또는 그 일부에 대한 안티센스 핵산, 또는
    (b) 상기 유전자의 전사 산물을 특이적으로 개열하는 리보자임 활성을 갖는 핵산.
  10. 제4항에 기재된 어느 하나의 유전자에 의해 코드되는 단백질의 기능을 억제하는 화합물을 유효성분으로서 함유하는 암세포 특이적 아포토시스 유도제.
  11. 제10항에 있어서,
    제4항에 기재된 어느 하나의 유전자에 의해 코드되는 단백질의 기능을 억제하는 화합물이 이하의 (a)~(c)의 어느 하나의 화합물인 아포토시스 유도제:
    (a) 상기 유전자에 의해 코드되는 단백질에 대해 우성 음성(dominant negative) 성질을 갖는 변이체 단백질;
    (b) 상기 유전자에 의해 코드되는 단백질에 결합하는 항체; 및
    (c) 상기 유전자에 의해 코드되는 단백질에 결합하는 저분자량 화합물.
  12. 제1항 내지 제11항 중 어느 한 항에 기재된 아포토시스 유도제를 유효성분으 로 포함하는 항암제.
  13. 이하의 (a)~(c)의 공정을 포함하는 암세포 특이적 아포토시스 유도제의 스크리닝 방법:
    (a) 제4항에 기재된 어느 하나의 유전자에 의해 코드되는 단백질 또는 그 부분 펩티드와 시험 화합물을 접촉시키는 공정;
    (b) 상기 단백질 또는 그 부분 펩티드와 시험 화합물의 결합 활성을 측정하는 공정; 및
    (c) 상기 유전자에 의해 코드되는 단백질 또는 그 부분 펩티드와 결합하는 화합물을 선택하는 공정.
  14. 이하의 (a)~(c)의 공정을 포함하는 암세포 특이적 아포토시스 유도제의 스크리닝 방법:
    (a) 제4항에 기재된 어느 하나의 유전자를 발현하는 세포 또는 세포 추출액과 시험 화합물을 접촉시키는 공정;
    (b) 상기 유전자의 발현 수준을 측정하는 공정; 및
    (c) 시험 화합물의 비존재하에 있어서 측정한 경우와 비교하여, 당해 발현 수준을 저하시키는 화합물을 선택하는 공정.
  15. 이하의 (a)~(c)의 공정을 포함하는 암세포 특이적 아포토시스 유도제의 스크 리닝 방법:
    (a) 제4항에 기재된 어느 하나의 유전자의 전사조절영역이 리포터 유전자와 기능적으로(operably) 결합한 구조를 갖는 DNA를 포함하는 세포 또는 세포 추출액과 시험 화합물을 접촉시키는 공정;
    (b) 상기 리포터 유전자의 발현 수준을 측정하는 공정; 및
    (c) 시험 화합물의 비존재하에 있어서 측정한 경우와 비교하여, 상기 발현 수준을 저하시키는 화합물을 선택하는 공정.
  16. 이하의 (a)~(c)의 공정을 포함하는 암세포 특이적 아포토시스 유도제의 스크리닝 방법:
    (a) 제4항에 기재된 어느 하나의 유전자에 의해 코드되는 단백질, 또는 당해 단백질을 발현하는 세포 또는 세포 추출액과 시험 화합물을 접촉시키는 공정;
    (b) 상기 단백질의 활성을 측정하는 공정; 및
    (c) 시험 화합물의 비존재하에 있어서 측정한 경우와 비교하여, 상기 단백질의 활성을 저하시키는 화합물을 선택하는 공정.
  17. 이하의 공정 (a) 및 (b)를 포함하는 제4항 또는 제10항에 기재된 아포토시스 유도제를 의약조성물로서 제조하는 방법:
    (a) 제13항 내지 제16항 중 어느 한 항에 기재된 방법에 의해 화합물을 스크리닝하는 공정; 및
    (b) 당해 화합물을 약학상 허용되는 담체와 혼합하는 공정.
KR1020067023433A 2004-04-09 2005-04-08 염색체 안정화에 관한 유전자를 표적으로 하는 암세포 특이적 아포토시스 유도제 KR101234281B1 (ko)

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