KR20060017130A - Composition for curing dermatitis - Google Patents

Abstract

The present invention relates to an external preparation for treating dermatitis, and more particularly, to an external preparation for treating dermatitis, which is effective in alleviating the symptoms of dermatitis and, in particular, in treating atopic dermatitis, without side effects. The present invention provides an external preparation for treating dermatitis, containing the 'tail of a flower' extract as an active ingredient. The 'tail of the flower' extract contains 0.01 to 30% by weight. The external preparation for treating dermatitis according to the present invention may optionally contain a ginseng extract and a moisturizing ingredient, and may include formulations such as liquids, ointments, creams, foams, solids, and packs that may be applied to the skin. . Accordingly, the present invention contains an 'flower tail' extract having an effect in the treatment of dermatitis as an active ingredient, even if used for a long time without side effects and can alleviate the symptoms of dermatitis, in particular can effectively treat atopic dermatitis An external preparation for treating dermatitis is provided.

Dermatitis, external preparation, atopic dermatitis, 'tail of a flower' extract, moisturizing ingredient

Description

External preparation for the treatment of dermatitis {Composition for curing dermatitis}

      The present invention relates to an external preparation for treating dermatitis, and more particularly, for treating dermatitis containing 'flower tail' extract and / or ginseng extract, which are effective in alleviating the symptoms of dermatitis and treating dermatitis without side effects. It is about an external preparation.

     In general, drugs for treating dermatitis such as acne, ringworm, athlete's foot, eczema, etc. are resorcinol, retinoic acid, tetracycline, hexachlorophene, pimaricin Antibacterial agents, such as amphotericin B, are commonly used. Such antimicrobial agents are obtained from molds or chemically synthesized and applied to the skin as external preparations in the form of solutions, ointments and the like. However, these synthetic antimicrobial agents are not necessarily satisfactory for the treatment of dermatitis. Above all, if the synthetic antimicrobial agent is not used properly according to the type of dermatitis due to the high manufacturing cost due to the synthesis and purification and the part of the cosmetic function has not been examined. It is accompanied by troubles, namely side effects from the use of antibacterial agents (secondary dermatitis).

      Accordingly, by containing a natural herbal extract (plant extract) with no side effects in the drug base for the treatment of dermatitis in recent years, natural herbal medicine that can have a skin whitening effect along with the therapeutic effect of dermatitis while excluding or reducing the amount of synthetic antimicrobial agents used. A pharmaceutical composition for treating dermatitis (dermatitis treatment) containing an extract has been proposed. In addition, a functional cosmetic composition has been proposed that can contain a natural herbal extract in the cosmetic base to have a skin whitening effect and a therapeutic effect of dermatitis.

      For example, Korean Laid-Open Patent Publication No. 2002-0013675 contains two or more complex herbal extracts selected from the group consisting of licorice, red ginseng, alum, sagan, gall bladder, bamboo shoot, cheongung, golden, yellow lotus and yellow white extract. One antimicrobial composition, cosmetic composition, soap, disinfecting cotton wool is shown. However, this is a complex use of several of the plants listed above, there is a problem in the process according to the complex extraction of them, above all, the therapeutic effect is minimal for atopic dermatitis, which has recently attracted social attention.

      Atopic dermatitis is a type of eczema of one of several species and is a representative disease of eczema, also called contact dermatitis. This atopic dermatitis has recently been attracting social attention because the number of children diagnosed with atopic dermatitis is increasing year by year, the disease recurs, and the social life of people involved in the disease because it does not heal as an adult This is a threatening situation.

     Currently, it is estimated that 10% to 20% of the world's population suffers from atopic dermatitis. Recently, due to an increase in the cause of airborne allergens due to environmental pollution and an increase in conditions for forming dry skin, For decades, the prevalence of atopic dermatitis continues to rise. However, as the etymology of the word atopy means “weird” or “inappropriate,” there is no known cause or obvious solution.

      Although typical symptoms of atopic dermatitis vary from person to person, the most common symptom is first complaints of extreme itching, second, the patient's skin to remain dry and unpleasant, and third, dry skin. Due to the loss of the protective function of the skin surface and irritants from the outside is easily allowed to invade the skin, due to this invasion of the skin causes a rejection inflammatory reaction occurs.

      For the treatment of atopic dermatitis, steroids, antihistamines, or antibiotics are used for secondary infections. However, steroids can cause side effects, including Cushing's syndrome. Injuries worsen due to disability, and even when used externally on the skin for a long time, not only side effects that weaken the skin resistance, but also withdrawal of the use of the steroidal contact dermatitis caused a serious symptom was not preferable.

     On the other hand, in order to improve atopic dermatitis, cosmetics mainly contain moisturizing ingredients with excellent moisturizing effects such as oils and high moisturizing factors in cosmetic bases, and mainly attempt to reduce the dryness of atopic skin rather than treating diseases. .

      In addition, according to a recent research report that ceramide (ceramide), which is one of skin keratinocyte lipids, is reduced in atopic skin, there is a cosmetic product for improving skin barrier function through ceramide. However, these moisturizing ingredients rely only on existing moisturizing effects, and the effects of improving the main symptoms of atopic skin such as itching are insignificant.

Therefore, there is an urgent need for an external preparation for treating dermatitis, which can be effectively treated while alleviating symptoms even when used for a long time for various dermatitis patients, especially atopic dermatitis patients, which are gradually increasing with environmental pollution.

     The present invention has been invented to solve the above problems, by containing a natural herbal extract that is effective in the treatment of dermatitis as an active ingredient, even if used for a long time without side effects and relieve symptoms of dermatitis, especially atopic An object of the present invention is to provide an external preparation for treating dermatitis, which can effectively treat dermatitis.

      In addition, the present invention provides an external preparation for treating dermatitis, which is effective in the treatment of skin whitening and dermatitis, in particular, atopic dermatitis, by further containing a moisturizing ingredient that can improve dryness of the skin together with the natural herbal extract as an active ingredient. Has a different purpose.

    In order to achieve the above object, the present invention provides an external preparation for treating dermatitis, containing the 'tail of a flower' extract and / or ginseng extract as an active ingredient.

    That is, the external preparation for treating dermatitis of the present invention contains the 'tail of the flower' extract or ginseng extract as an active ingredient for the treatment of dermatitis, or contains the mixed herbal extract consisting of the 'tail of the flower' extract and the ginseng extract. . In the present invention, 'external preparation' is applied to the skin by a method such as applying, applying, etc., if used as conventional skin external preparations such as liquids, ointments, creams, foams, solids, packs, etc. In the present invention, the formulation is not particularly limited.

     In addition, the external preparation for the treatment of dermatitis according to the present invention contains 'flower tail' extract and / or ginseng extract as an essential ingredient, and is a component used in external preparations for skin, such as pharmaceuticals and cosmetics, for example, an oily component, water, and an interface. Active agents, thickeners, alcohols, powder ingredients, colorants, flavors, preservatives, antioxidants, whitening agents, moisturizers, various skin nutrients and the like are appropriately selected and contained.

      Therefore, the external preparation for treating dermatitis according to the present invention includes a pharmaceutical composition for treating dermatitis (dermatitis treatment) and a functional cosmetic composition having a dermatitis treatment function such as basic cosmetics and body cosmetics. Specific examples of the cosmetic composition include a cream, a foam, a lotion, a pack, an emulsion, and the like, and the body cosmetics include a soap and a wooden solvent (body shampoo).

     The inventors of the present invention, which has been traditionally used in folk medicine and secured its effectiveness and safety, have shown that the 'tail of the flower' extract and the ginseng extract have no side effects even when applied to the skin for a long time without causing side effects. The present invention has been found to have an antimicrobial and itching inhibitory effect and a skin whitening effect, and in particular, to atopic dermatitis patients, having an excellent therapeutic effect and completing the present invention.

      Hereinafter, the present invention will be described in detail.

The 'tail of the flower' used in the present invention is a perennial plant having the scientific name of 'Pisostegia virginiana ' ( Physostegia virginiana ), and grows well in sandy loam, which is well drained around 60-120 cm. Native to North America, it is a naturalized plant that is commonly used as an ornamental plant and is planted in red, purple and white in July and September.

      The external preparation for treating dermatitis according to the present invention contains an extract of the above-mentioned 'tail of a flower', and the 'tail of the flower' may be obtained by a hydrothermal extraction method or a solvent extraction method.

     To illustrate the method of extracting hot water, finely pulverize the well-dried 'tailer's tail' or the 'tailer's tail' which has been collected in nature, and then put it in distilled water and leave it at room temperature for about 24 hours, and then 30 minutes. Boil for 120 minutes, filter, and centrifuge to take supernatant. Then, the supernatant was heated to about 50 ~ 80 ℃ in a rotary vacuum evaporator, depressurized, concentrated and then lyophilized with a lyophilizer to obtain the 'tail of the flower'.

     As an example of extraction with a solvent, finely pulverize the well-dried 'tail of the flower' or the tail of the flower, which has been collected in nature, finely crushed, and put it in the extraction solvent and soak for about 24 hours at room temperature. The supernatant is taken by filtration and centrifugation. At this time, the extraction solvent may be water, methanol aqueous solution, ethanol aqueous solution, butylene glycol aqueous solution, propylene glycol aqueous solution, glycerin aqueous solution or a mixed solvent thereof. Then, the supernatant was heated to about 50 ~ 80 ℃ in a rotary vacuum evaporator, depressurized, concentrated and then lyophilized with a lyophilizer to obtain the 'tail of the flower'.

Further, as a perennial plant gwonsam is having a country name of "bis tor other top tertiary N-Sys (Bistorta manshuriensis), and the scientific name of" common bistort "used in the present invention, it is distributed in Korea, shares, Amour, odd or the like. Root stocks are thick and dark brown with beard roots. Stems stand upright, branches are not split, outer shell is magenta. Usually, it is known to have an effect on exercise diseases, schizophrenia, etc., and when used as a medicine, it is used as a pill or as a pill or powder. Ingredients include tannins 8-25%, starch 12-45% and sugars 5.7-8.5%.

     The ginseng extract as described above may be obtained by a hot water extraction method or a solvent extraction method as the 'tail of the flower' extract.

      According to the present invention, the 'tail of the flower' and the ginseng extract are contained alone or mixed as an active ingredient of the dermatitis treatment according to the present invention.

      According to the present invention, the 'tail of the flower' and the ginseng extract as described above inhibit the activity of various dermatitis-inducing bacteria, has a skin whitening function, it can be seen that there is no side effect even if applied to the skin for a long time by applying to gauze there was. In particular, it was found that it is effective for atopic dermatitis. The ginseng extract has a particularly effective skin itching effect, and when mixed with the 'tail of the flower' extract, it is more effective in treating atopic dermatitis.

      The 'flower tail' extract and / or ginseng extract as described above is a pharmaceutical composition for treating dermatitis (dermatitis treatment), cosmetic composition (cream, foam, lotion, pack, milky lotion, soap composition) that can be applied as a skin external preparation according to the present invention ( Soap), bath solvent) and the like.

       The 'tail of the flower' extract and / or ginseng extract is 100% by weight of each composition (pharmaceutical composition, cosmetic composition, etc.) to 100% by weight of the skin external preparation (total weight containing the 'tail of the flower' extract) It is preferable to contain 0.01 to 30% by weight relative to. That is, it is preferable that the 'tail of the flower' extract or the ginseng extract contains 0.01% by weight to 30% by weight, or the 'tail of the flower' extract and the ginseng extract are mixed to contain 0.01% by weight to 30% by weight. . If the extract contains less than 0.01% by weight can not exhibit the sufficient effect of the desired dermatitis treatment in the present invention, if it exceeds 30% by weight it is difficult to formulate the drug, cosmetics, soap, bath solvent, etc. There is an inconvenience in obtaining the formulation.

       In addition, in order to achieve the synergistic effect of skin whitening, the external preparation for treating dermatitis according to the present invention preferably contains a moisturizing ingredient in addition to the 'tail of the' flower 'extract and / or ginseng extract.

According to the present invention, the 'tail of the flower' extract and the ginseng extract have an excellent therapeutic effect, especially in atopic dermatitis, among the dermatitis, in order to maintain a wet state on the skin for more effective treatment of atopic dermatitis It is preferred to contain a moisturizing ingredient in addition to the extract and / or ginseng extract. The moisturizing component may be used a conventional moisturizing component, it is preferable to use ceramide or oil alone or to mix them. At this time, although not particularly limited, the total amount of the 'tail of the flower' extract and / or ginseng extract and the moisturizing component is contained so that 0.02 to 35% by weight based on 100% by weight of the external preparation. That is, the moisturizing component is preferably such that 0.01 to 5% by weight based on 100% by weight of the external preparation as a ceramide or oil alone or as a mixture.

     In the present invention, the 'tail of the flower' extract and / or ginseng extract may be included in the process of preparing a pharmaceutical composition, cosmetic composition, etc., and may be separately mixed in an appropriate amount after preparation. For example, the process of mixing the cosmetic composition with a cosmetic composition base which may have a formulation such as a liquid formulation (a lotion, an emulsion, a bath solvent, etc.), a cream formulation (nutrition cream, a massage cream, etc.), a foaming agent (a cleansing foam, etc.) It can be contained in, or can be mixed in the prepared cosmetics.

      In the following, exemplary embodiments of the present invention are described. The following examples illustrate the cosmetic composition as an external preparation for skin of the present invention in order to explain the present invention in detail, and the technical scope of the present invention is not limited by these examples to those skilled in the art. It will be obvious.

Extract Preparation Example 1-Hot Water Extraction

      Finely pulverized 'tail of the flower' and ginsam each finely ground and mixed with each other in a 1: 1 weight ratio, 500ml of distilled water was added to 40g of the mixed ground ground and left for 24 hours at room temperature, and then boiled for 1 hour. Then, the residue was removed, filtered using filter paper, and centrifuged at 10,000 rpm for 10 minutes in a centrifuge to take only the supernatant. The supernatant was heated to 60 ° C. in a rotary vacuum evaporator, concentrated under reduced pressure, and lyophilized with a freeze dryer.

[Extract Preparation Example 2]-Solvent Extraction

      Finely pulverized 'tail tail' and ginseng were finely ground and mixed together in a 1: 1 weight ratio, and 40 g of the mixed pulverized product was put in 500 ml of ethanol aqueous solution (80 wt%) and deposited at room temperature for 24 hours. Then, after removing the residue, it was filtered using a filter paper and centrifuged at 10,000 rpm for 10 minutes in a centrifuge to take only the supernatant. The supernatant was heated to 60 ° C. in a rotary vacuum evaporator, concentrated under reduced pressure, and lyophilized with a freeze dryer.

Example 1

      To prepare a liquid functional cosmetics by mixing and stirring 5% by weight of the mixed extract of the 'tail of a flower' and Kwonsam prepared in the extract preparation example 1 and 0.5% by weight of ceramide as a moisturizing ingredient to a conventional liquid cosmetic composition base.

Example 2

       A cream functional cosmetic was prepared by mixing and stirring 5% by weight of the mixed extract of 'tail of a flower' and Kwonsam prepared in the extract preparation example 1 and 0.5% by weight of ceramide as a moisturizing ingredient in a base of a conventional cream cosmetic composition. .                     

Example 3

        To prepare a foam functional cosmetics by mixing and stirring 5% by weight of the mixed extract of the 'tail of a flower' and Kwonsam prepared in the extract preparation example 2 and 0.5% by weight of ceramide as a moisturizing ingredient to a conventional foam cosmetic composition base. . The composition of this example is shown in the following [Table 5].

     The therapeutic effect of the cosmetics prepared in Examples 1 to 3 for atopic dermatitis was evaluated. The evaluation method and result are as follows.

<Effect test example 1>

      In this test example, 30 patients with atopic dermatitis with a genetic predisposition to atopic dermatitis were applied, and the cosmetics prepared in Examples (1 to 3) were applied at the same dosage and dosage as the conventional cosmetics for 3 months. It was made.

As a result, 14 of the 30 patients had ameliorated symptoms of atopic dermatitis, 7 had some relief, 5 had little effect, and 4 had little change. The relief of the symptoms here means that the itching has subsided and the skin redness has subsided. In neither case, there was no hypersensitivity reaction or side effects caused by cosmetics.

<Effect Test Example 2>

      In this test example, 30 patients with atopic dermatitis without genetic predisposition to atopic dermatitis were applied, and the cosmetics prepared in Examples (1 to 3) were applied at the same dosage and dosage as the conventional cosmetic products for 3 months. It was made.                     

As a result, 22 out of 30 had almost recovered from atopic dermatitis, 7 had been alleviated considerably, and 3 had some relief. The relief of the symptoms here means that the itching has subsided and the skin redness has subsided. In addition, as in the above case, there was no hypersensitivity reaction or side effects caused by cosmetics.

      Therefore, the present invention contains an 'flower tail' extract having an effect on the treatment of dermatitis as an active ingredient, even if used for a long time without side effects and alleviate the symptoms of dermatitis, in particular dermatitis that can effectively treat atopic dermatitis Provide a therapeutic external preparation.

In addition, the present invention provides a topical agent for the treatment of dermatitis, which is effective in the treatment of dermatitis, in particular in the treatment of atopic dermatitis, with skin whitening effect by further comprising the ginseng extract and moisturizing ingredients as an active ingredient in addition to the 'tail of the flower' extract. .

Claims (6)

       External preparation for the treatment of dermatitis, comprising the 'tail of the flower' extract and / or ginseng extract as an active ingredient.       The external preparation for treating dermatitis according to claim 1, wherein the 'tail of a' flower 'extract and / or ginseng extract contains 0.01 wt% to 30 wt%.       The method of claim 1, wherein the 'tail of the flower' extract and / or ginseng extract is finely ground chopped ginseng in distilled water and left at room temperature for 24 hours, then boiled for 30 minutes to 120 minutes, filtered and centrifuged supernatant After taking this, the supernatant was heated to about 50 ~ 80 ℃ in a rotary vacuum evaporator, reduced pressure, concentrated and then lyophilized external preparation for dermatitis treatment.        The external preparation for treating dermatitis according to claim 1, further comprising a moisturizing ingredient. The external preparation for treating dermatitis according to claim 4, wherein the moisturizing component is contained in an amount of 0.01 to 5% by weight, either alone or as a mixture of ceramide or oil. The external preparation for treating dermatitis according to any one of claims 1 to 5, wherein the external preparation is a pharmaceutical composition or cosmetic composition for treating dermatitis.