KR20060009846A - Ｐｐａｒ 조절자로서의 알파 치환된 카복실산 - Google Patents
Ｐｐａｒ 조절자로서의 알파 치환된 카복실산 Download PDFInfo
- Publication number
- KR20060009846A KR20060009846A KR1020057019591A KR20057019591A KR20060009846A KR 20060009846 A KR20060009846 A KR 20060009846A KR 1020057019591 A KR1020057019591 A KR 1020057019591A KR 20057019591 A KR20057019591 A KR 20057019591A KR 20060009846 A KR20060009846 A KR 20060009846A
- Authority
- KR
- South Korea
- Prior art keywords
- methyl
- phenyl
- oxazol
- ethoxy
- formula
- Prior art date
Links
- 0 *c(cc1)ccc1C1=NC=C=C1 Chemical compound *c(cc1)ccc1C1=NC=C=C1 0.000 description 8
- AUSUPLOVHHBOEY-UHFFFAOYSA-O CC(C)(C(O)=O)Oc1cccc(-c2cc(OCCC(CC3)CCN3C(N)=CC=C(C)[NH3+])ccc2)c1 Chemical compound CC(C)(C(O)=O)Oc1cccc(-c2cc(OCCC(CC3)CCN3C(N)=CC=C(C)[NH3+])ccc2)c1 AUSUPLOVHHBOEY-UHFFFAOYSA-O 0.000 description 1
- CDRIZXUWMMVWTQ-VQHVLOKHSA-N CCOC(C1(CCC1)Oc1ccc(/C=C/Cc2c(C)[o]c(-c3ccccc3)n2)cc1)=O Chemical compound CCOC(C1(CCC1)Oc1ccc(/C=C/Cc2c(C)[o]c(-c3ccccc3)n2)cc1)=O CDRIZXUWMMVWTQ-VQHVLOKHSA-N 0.000 description 1
- LICMWBWCSGKWNX-UHFFFAOYSA-N CCOC(C1(Cc(cc2)cnc2OCCc2c(C)[o]c(-c3ccccc3)n2)OCCC1)=O Chemical compound CCOC(C1(Cc(cc2)cnc2OCCc2c(C)[o]c(-c3ccccc3)n2)OCCC1)=O LICMWBWCSGKWNX-UHFFFAOYSA-N 0.000 description 1
- GQQLWKZRORYGHY-UHFFFAOYSA-N CCOC(C1OCCC1)=O Chemical compound CCOC(C1OCCC1)=O GQQLWKZRORYGHY-UHFFFAOYSA-N 0.000 description 1
- YGPBAGVCOGYWJI-UHFFFAOYSA-N CCOC(Cc(cn1)ccc1OCCc1c(C)[o]c(-c2ccccc2)n1)C(OCC)=O Chemical compound CCOC(Cc(cn1)ccc1OCCc1c(C)[o]c(-c2ccccc2)n1)C(OCC)=O YGPBAGVCOGYWJI-UHFFFAOYSA-N 0.000 description 1
- FGKGPWJVDRKQKT-UHFFFAOYSA-N COC(C1(CCOCC1)C(c(cc1)ccc1OCCC=C)O)=O Chemical compound COC(C1(CCOCC1)C(c(cc1)ccc1OCCC=C)O)=O FGKGPWJVDRKQKT-UHFFFAOYSA-N 0.000 description 1
- IPWZPTYWJHXUHD-UHFFFAOYSA-N Cc1c(CCOc2ccc(C=O)cc2)nc(-c2ccccc2)[o]1 Chemical compound Cc1c(CCOc2ccc(C=O)cc2)nc(-c2ccccc2)[o]1 IPWZPTYWJHXUHD-UHFFFAOYSA-N 0.000 description 1
- LNHMHVXNKZZZCI-UHFFFAOYSA-N Cc1c(CCOc2ccc(CC3(CCCCC3)C(O)=O)cc2)nc(-c2ccccc2)[o]1 Chemical compound Cc1c(CCOc2ccc(CC3(CCCCC3)C(O)=O)cc2)nc(-c2ccccc2)[o]1 LNHMHVXNKZZZCI-UHFFFAOYSA-N 0.000 description 1
- KLUDVNCBKDPJBN-UHFFFAOYSA-N Cc1c(CCOc2ccc(CI)cn2)nc(-c2ccccc2)[o]1 Chemical compound Cc1c(CCOc2ccc(CI)cn2)nc(-c2ccccc2)[o]1 KLUDVNCBKDPJBN-UHFFFAOYSA-N 0.000 description 1
- GXHAENUAJYZNOA-UHFFFAOYSA-N NC(C1OCCC1)=O Chemical compound NC(C1OCCC1)=O GXHAENUAJYZNOA-UHFFFAOYSA-N 0.000 description 1
- VQGHOUODWALEFC-UHFFFAOYSA-N c(cc1)ccc1-c1ncccc1 Chemical compound c(cc1)ccc1-c1ncccc1 VQGHOUODWALEFC-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
- C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/14—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
- C07C62/34—Unsaturated compounds containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Furan Compounds (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46321303P | 2003-04-15 | 2003-04-15 | |
| US60/463,213 | 2003-04-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20060009846A true KR20060009846A (ko) | 2006-02-01 |
Family
ID=33300053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020057019591A KR20060009846A (ko) | 2003-04-15 | 2004-04-01 | Ｐｐａｒ 조절자로서의 알파 치환된 카복실산 |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP1615899A1 (fr) |
| JP (1) | JP2006523671A (fr) |
| KR (1) | KR20060009846A (fr) |
| CN (1) | CN1805943A (fr) |
| AP (1) | AP2005003418A0 (fr) |
| AR (1) | AR044514A1 (fr) |
| AU (1) | AU2004230316A1 (fr) |
| BR (1) | BRPI0409429A (fr) |
| CA (1) | CA2521915A1 (fr) |
| CL (1) | CL2004000800A1 (fr) |
| EA (1) | EA200501462A1 (fr) |
| EC (1) | ECSP056105A (fr) |
| IS (1) | IS8033A (fr) |
| MA (1) | MA27764A1 (fr) |
| MX (1) | MXPA05010967A (fr) |
| NL (1) | NL1025946C2 (fr) |
| NO (1) | NO20055370L (fr) |
| OA (1) | OA13157A (fr) |
| PA (1) | PA8600201A1 (fr) |
| PE (1) | PE20050415A1 (fr) |
| TN (1) | TNSN05262A1 (fr) |
| TW (1) | TW200510353A (fr) |
| UY (1) | UY28266A1 (fr) |
| WO (1) | WO2004092145A1 (fr) |
| ZA (1) | ZA200508362B (fr) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2567437A1 (fr) * | 2004-05-25 | 2005-12-08 | Metabolex, Inc. | Triazoles substitues comme modulateurs de ppar et methodes de preparation |
| AP2358A (en) | 2005-05-09 | 2012-01-30 | Achillion Pharmaceuticals Inc | Thiazole compounds and methods of use. |
| CN101553475B (zh) | 2006-10-30 | 2013-04-24 | 色品疗法有限公司 | 作为组蛋白脱乙酰基酶抑制剂的异羟肟酸 |
| PT2125711E (pt) | 2007-03-08 | 2014-02-05 | Albireo Ab | Pirimidinas como inibidores de quinase |
| MX2009012613A (es) | 2007-05-22 | 2010-04-21 | Achillion Pharmaceuticals Inc | Tiazoles substituidos por heteroarilo y su uso como agentes antivirales. |
| US8106209B2 (en) | 2008-06-06 | 2012-01-31 | Achillion Pharmaceuticals, Inc. | Substituted aminothiazole prodrugs of compounds with anti-HCV activity |
| NZ602832A (en) | 2008-07-14 | 2014-04-30 | Gilead Sciences Inc | Fused heterocyclic hdac inhibitor compounds |
| WO2010009139A2 (fr) | 2008-07-14 | 2010-01-21 | Gilead Colorado, Inc. | Composés inhibiteurs de pyrimidine imidazolyle |
| WO2010009166A1 (fr) | 2008-07-14 | 2010-01-21 | Gilead Colorado, Inc. | Composés inhibiteurs de l’oxindolyle |
| AU2009276699A1 (en) | 2008-07-28 | 2010-02-04 | Gilead Sciences, Inc. | Cycloalkylidene and heterocycloalkylidene histone deacetylase inhibitor compounds |
| MX2011013165A (es) | 2009-06-08 | 2012-01-30 | Gilead Sciences Inc | Compuestos inhibidores de hdac de alcanoilamino-benzamida-anilina. |
| JP2012529514A (ja) | 2009-06-08 | 2012-11-22 | ギリアード サイエンシーズ， インコーポレイテッド | シクロアルキルカルバメートベンズアミドアニリンｈｄａｃ阻害剤化合物 |
| DE102010055499A1 (de) * | 2010-12-22 | 2011-06-16 | W.C. Heraeus Gmbh | Prozess zur Herstellung von Bendamustinalkylester, Bendarmustin sowie Derivaten davon |
| BR112014010368A2 (pt) | 2011-10-31 | 2017-04-25 | Xenon Pharmaceuticals Inc | biaril éter sulfonamidas e seu uso como agentes terapêuticos |
| RU2014121984A (ru) | 2011-10-31 | 2015-12-10 | Ксенон Фармасьютикалз Инк. | Бензолсульфонамидные соединения и их применение в качестве терапевтических средств |
| FR2982858B1 (fr) * | 2011-11-18 | 2013-11-29 | Rhodia Operations | Procede de fabrication de composes comprenant des fonctions nitriles |
| FR2984322B1 (fr) * | 2011-12-16 | 2013-12-20 | Rhodia Operations | Procede de fabrication de composes comprenant des fonctions nitriles |
| SG11201408284VA (en) | 2012-05-22 | 2015-02-27 | Xenon Pharmaceuticals Inc | N-substituted benzamides and their use in the treatment of pain |
| EP2870138B1 (fr) | 2012-07-06 | 2018-08-22 | Genentech, Inc. | Benzamides n-substitués et leurs procédés d'utilisation |
| EP2968280A4 (fr) | 2013-03-14 | 2016-08-10 | Genentech Inc | Triazolopyridines substituées et leurs procédés d'utilisation |
| MX2015010775A (es) | 2013-03-15 | 2016-04-25 | Genentech Inc | Benzoxazoles sustituidos y metodos para usarlos. |
| CN105793238B (zh) | 2013-11-27 | 2019-12-24 | 基因泰克公司 | 经取代的苯甲酰胺及其使用方法 |
| EP3166939B1 (fr) | 2014-07-07 | 2019-06-05 | Genentech, Inc. | Composés thérapeutiques et leurs méthodes utilisation |
| WO2016191312A1 (fr) | 2015-05-22 | 2016-12-01 | Genentech, Inc. | Benzamides substitués et leurs méthodes d'utilisation |
| JP2018526371A (ja) | 2015-08-27 | 2018-09-13 | ジェネンテック， インコーポレイテッド | 治療化合物及びその使用方法 |
| KR20180067561A (ko) | 2015-09-28 | 2018-06-20 | 제넨테크, 인크. | 치료 화합물 및 그의 사용 방법 |
| WO2017091592A1 (fr) | 2015-11-25 | 2017-06-01 | Genentech, Inc. | Benzamides substitués utiles en tant que bloqueurs de canaux sodiques |
| EP3854782A1 (fr) | 2016-03-30 | 2021-07-28 | Genentech, Inc. | Benzamides substitués et leurs procédés d'utilisation |
| KR20190078587A (ko) | 2016-10-17 | 2019-07-04 | 제넨테크, 인크. | 치료 화합물 및 그의 사용 방법 |
| JP2020511511A (ja) | 2017-03-24 | 2020-04-16 | ジェネンテック， インコーポレイテッド | ナトリウムチャネル阻害剤としての４−ピペリジン−ｎ−（ピリミジン−４−イル）クロマン−７−スルホンアミド誘導体 |
| TW202000651A (zh) | 2018-02-26 | 2020-01-01 | 美商建南德克公司 | 治療性組成物及其使用方法 |
| US10947251B2 (en) | 2018-03-30 | 2021-03-16 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| ATE257480T1 (de) * | 1999-09-30 | 2004-01-15 | Pfizer Prod Inc | Bicyclische pyrrolylamide als glycogenphosphorylase-inhibitoren |
| JP2004520397A (ja) * | 2001-02-15 | 2004-07-08 | ファイザー・プロダクツ・インク | 増殖性アクチベータ受容体（ｐｐａｒ）化合物 |
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- 2004-04-01 JP JP2006506478A patent/JP2006523671A/ja active Pending
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- 2004-04-01 AU AU2004230316A patent/AU2004230316A1/en not_active Abandoned
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- 2004-04-01 WO PCT/IB2004/001159 patent/WO2004092145A1/fr not_active Application Discontinuation
- 2004-04-01 CN CNA2004800167362A patent/CN1805943A/zh active Pending
- 2004-04-12 PE PE2004000361A patent/PE20050415A1/es not_active Application Discontinuation
- 2004-04-13 UY UY28266A patent/UY28266A1/es not_active Application Discontinuation
- 2004-04-13 AR ARP040101236A patent/AR044514A1/es unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| ECSP056105A (es) | 2006-03-01 |
| AP2005003418A0 (en) | 2005-12-31 |
| WO2004092145A8 (fr) | 2005-05-12 |
| MXPA05010967A (es) | 2005-11-28 |
| ZA200508362B (en) | 2006-11-29 |
| CN1805943A (zh) | 2006-07-19 |
| MA27764A1 (fr) | 2006-02-01 |
| CA2521915A1 (fr) | 2004-10-28 |
| AU2004230316A1 (en) | 2004-10-28 |
| EP1615899A1 (fr) | 2006-01-18 |
| NL1025946A1 (nl) | 2004-10-18 |
| WO2004092145A1 (fr) | 2004-10-28 |
| BRPI0409429A (pt) | 2006-04-18 |
| OA13157A (en) | 2006-12-13 |
| JP2006523671A (ja) | 2006-10-19 |
| EA200501462A1 (ru) | 2006-04-28 |
| TNSN05262A1 (fr) | 2007-07-10 |
| UY28266A1 (es) | 2004-11-30 |
| CL2004000800A1 (es) | 2005-03-04 |
| NL1025946C2 (nl) | 2005-02-01 |
| PA8600201A1 (es) | 2005-02-04 |
| TW200510353A (en) | 2005-03-16 |
| AR044514A1 (es) | 2005-09-14 |
| NO20055370L (no) | 2006-01-12 |
| NO20055370D0 (no) | 2005-11-14 |
| IS8033A (is) | 2005-09-15 |
| PE20050415A1 (es) | 2005-06-13 |
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