KR20050044858A - 화학적으로 개질된 인간 성장 호르몬 콘쥬게이트 - Google Patents

화학적으로 개질된 인간 성장 호르몬 콘쥬게이트 Download PDF

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Publication number
KR20050044858A
KR20050044858A KR1020047007708A KR20047007708A KR20050044858A KR 20050044858 A KR20050044858 A KR 20050044858A KR 1020047007708 A KR1020047007708 A KR 1020047007708A KR 20047007708 A KR20047007708 A KR 20047007708A KR 20050044858 A KR20050044858 A KR 20050044858A
Authority
KR
South Korea
Prior art keywords
conjugate
hgh
group
peg
poly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
KR1020047007708A
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English (en)
Korean (ko)
Inventor
로리 에프. 핀
웨이 라오
네드 알. 시겔
Original Assignee
파마시아 코포레이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 파마시아 코포레이션 filed Critical 파마시아 코포레이션
Publication of KR20050044858A publication Critical patent/KR20050044858A/ko
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Reproductive Health (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
KR1020047007708A 2001-11-20 2002-11-20 화학적으로 개질된 인간 성장 호르몬 콘쥬게이트 Abandoned KR20050044858A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33190701P 2001-11-20 2001-11-20
US60/331,907 2001-11-20

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020077011730A Division KR20070072924A (ko) 2001-11-20 2002-11-20 화학적으로 개질된 인간 성장 호르몬 콘쥬게이트

Publications (1)

Publication Number Publication Date
KR20050044858A true KR20050044858A (ko) 2005-05-13

Family

ID=23295870

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020077011730A Withdrawn KR20070072924A (ko) 2001-11-20 2002-11-20 화학적으로 개질된 인간 성장 호르몬 콘쥬게이트
KR1020047007708A Abandoned KR20050044858A (ko) 2001-11-20 2002-11-20 화학적으로 개질된 인간 성장 호르몬 콘쥬게이트

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1020077011730A Withdrawn KR20070072924A (ko) 2001-11-20 2002-11-20 화학적으로 개질된 인간 성장 호르몬 콘쥬게이트

Country Status (25)

Country Link
EP (1) EP1453859A2 (enExample)
JP (2) JP2005525302A (enExample)
KR (2) KR20070072924A (enExample)
CN (1) CN1608079A (enExample)
AP (1) AP2004003050A0 (enExample)
AU (1) AU2002356990A1 (enExample)
BR (1) BR0214451A (enExample)
CA (1) CA2467731A1 (enExample)
CO (1) CO5580794A2 (enExample)
EA (2) EA008505B1 (enExample)
EC (1) ECSP045114A (enExample)
GE (1) GEP20063860B (enExample)
HR (1) HRP20040448A2 (enExample)
HU (1) HUP0500997A2 (enExample)
IL (1) IL162031A0 (enExample)
IS (1) IS7268A (enExample)
MA (1) MA27544A1 (enExample)
MX (1) MXPA04004809A (enExample)
NO (1) NO20042182L (enExample)
OA (1) OA13063A (enExample)
PL (1) PL374354A1 (enExample)
RS (1) RS53104A (enExample)
TN (1) TNSN04090A1 (enExample)
WO (1) WO2003044056A2 (enExample)
ZA (1) ZA200403907B (enExample)

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CN101108895B (zh) * 2006-07-19 2011-10-26 北京键凯科技有限公司 聚乙二醇乙醛衍生物及其与药物的结合物
AU2007310777A1 (en) 2006-10-26 2008-05-02 Novo Nordisk A/S IL-21 variants
CL2008002399A1 (es) * 2007-08-16 2009-01-02 Pharmaessentia Corp Conjugado sustancialmente puro que posee una porcion polimerica, una porcion proteica (interferon alfa 2b) y un ligante alifatico de 1 a 10 atomos de carbono, util en el tratamiento de las hepatitis b o c.
EP2272875B1 (en) * 2008-04-03 2014-01-15 Biosteed Gene Expression Tech. CO., LTD. Double-stranded polyethylene glycol modified growth hormone, preparation method and application thereof
PT3050576T (pt) 2008-04-29 2021-06-01 Ascendis Pharma Growth Disorders Div A/S Compostos recombinantes e peguilados da hormona de crescimento humana
KR101104574B1 (ko) * 2008-05-14 2012-01-11 성균관대학교산학협력단 폴리에틸렌글리콜로 화학적으로 수식된 인간 성장 호르몬, 이의 제조방법 및 용도
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US8492503B2 (en) * 2008-09-11 2013-07-23 Nektar Therapeutics Polymeric alpha-hydroxy aldehyde and ketone reagents and conjugation method
JP5816097B2 (ja) 2009-01-22 2015-11-18 ノヴォ・ノルディスク・ヘルス・ケア・アーゲー 安定な成長ホルモン化合物
US8841249B2 (en) 2009-08-06 2014-09-23 Novo Nordisk A/S Growth hormones with prolonged in-vivo efficacy
LT2512450T (lt) 2009-12-15 2018-04-25 Ascendis Pharma Endocrinology Division A/S Sausa augimo hormono kompozicija, laikinai prijungta prie polimero nešiklio
AU2011208620B2 (en) 2010-01-22 2015-04-16 Novo Nordisk Health Care Ag Stable growth hormone compounds
SI2525834T1 (sl) 2010-01-22 2019-10-30 Novo Nordisk Healthcare Ag Rastni hormoni s podaljšano in vivo učinkovitostjo
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EA019967B1 (ru) * 2011-12-21 2014-07-30 Общество С Ограниченной Ответственностью "Форт" (Ооо "Форт") Ковалентный конъюгат полиэтиленгликоля с гормоном роста человека
CN105120887A (zh) 2013-04-05 2015-12-02 诺和诺德保健股份有限公司 生长激素化合物制剂
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Also Published As

Publication number Publication date
HRP20040448A2 (en) 2006-02-28
KR20070072924A (ko) 2007-07-06
CA2467731A1 (en) 2003-05-30
ZA200403907B (en) 2007-12-27
EA200700431A1 (ru) 2008-02-28
JP2005525302A (ja) 2005-08-25
AP2004003050A0 (en) 2004-06-30
EA008505B1 (ru) 2007-06-29
TNSN04090A1 (fr) 2006-06-01
GEP20063860B (en) 2006-06-26
WO2003044056A3 (en) 2003-08-21
OA13063A (en) 2006-11-10
IS7268A (is) 2004-05-17
JP2006321808A (ja) 2006-11-30
EP1453859A2 (en) 2004-09-08
BR0214451A (pt) 2006-05-30
AU2002356990A1 (en) 2003-06-10
RS53104A (sr) 2006-10-27
MA27544A1 (fr) 2005-10-03
ECSP045114A (es) 2004-07-23
EA200400565A1 (ru) 2005-06-30
HUP0500997A2 (en) 2007-11-28
CN1608079A (zh) 2005-04-20
WO2003044056A2 (en) 2003-05-30
MXPA04004809A (es) 2004-08-11
CO5580794A2 (es) 2005-11-30
NO20042182L (no) 2004-08-11
PL374354A1 (en) 2005-10-17
IL162031A0 (en) 2005-11-20

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