KR20040083843A - Cosmetic Compositions for Skin-Whitening Comprising Phytolight and Lactate as Active Ingredients - Google Patents

Abstract

PURPOSE: Provided is a skin-whitening cosmetic composition comprising phytolight and lactate as active ingredients for skin whitening. The compos ion maximizes skin whitening effect by co-acting phytolight and lactate and has improved skin stability. CONSTITUTION: The skin-whitening cosmetic composition is characterized by comprising 1-20 wt.% of phytolight and 0.001-10 wt.% of lactate, based on the total weight of the composition. The phytolight is extracted from Scutellaria baicalensis Geogri, apples, the leaf of Camellia japonica L., cucumber and their mixture.

Description

Cosmetic Compositions for Skin-Whitening Comprising Phytolight and Lactate as Active Ingredients}

The present invention relates to a whitening cosmetic composition, and more particularly to a whitening cosmetic composition comprising lactate and phytolight as a whitening active ingredient.

The color of human skin, hair, and eyes is determined by melanin, carotene and hemoglobin, and the most important factor in determining the color of skin is melanin. The color of skin depends on the amount, nature and distribution of melanin. .

In humans, pigments in the skin and hair protect against the harmful effects of sunlight (especially ultraviolet rays). For example, people with poor pigmentation are very sensitive to sunlight and are prone to burns and have a high probability of developing skin cancer even at a young age. Short wavelength ultraviolet (290-320 nm) and carcinogens form harmful radicals in the skin, which are known to attack skin cells and age the skin.

The main function of melanin is to remove these harmful radicals and protect the skin from the damage thereby. Therefore, high levels of melanin mean that it has an effective response system to protect the skin from physical and chemical toxicants. Factors that promote the production of melanin include sunlight (particularly ultraviolet rays) as well as hormones such as estrogen and prostaglandins.

Melanin is produced by complex oxidation and condensation reactions of melanocytes in the melanosite by sunlight (ultraviolet rays), which are converted to dopa and dopachrome by an enzyme called tyrosinase. The resulting melanin is delivered to the skin cells and exhibits a circulating action in which the melanin is lost and disappeared along with epidermal detachment. The melanin-generating mechanism is characterized by the involvement of only one enzyme, tyrosinase, which can be expected to whiten by inhibiting tyrosinase activity and preventing melanin production.

The method of inhibiting melanin production in whitening cosmetics can be divided into the following. One method is to block and remove ultraviolet rays, which are the main cause of melanin production, and this method can be expected to include good light scattering agent or light blocking agent in the cosmetic composition. Another method is to inhibit melanin production by inhibiting the synthesis of core carbohydrates required for tyrosinase to be active, such as glucosamine. There are also methods that interfere with the function of tyrosinase involved in melanogenesis, such as enzyme acid (kojic acid) or arbutin. Another method is to disrupt cell division because it has specific toxicity against melanocytes, which are melanin-producing cells such as hydroquinone. Like vitamin C, there is also a way to expect whitening effect by showing strong antioxidant effect during tyrosine through complex oxidation and condensation reaction through dopa and dopachrome.

To date, the use of ascorbic acid (Japanese Patent Application Laid-Open No. 4-9320) has been proposed to show a whitening effect. However, since ascorbic acid itself has poor phase stability in the prescription system, the active ingredient's activity decreases with time, and various methods such as stabilization with capsules and liposomes have recently been proposed. have.

Another whitening cosmetic, especially hydroquinone (Japanese Patent Laid-Open No. 6-192062), has an excellent effect, but is limited to its use as a cosmetic since it is a carcinogenic substance. Another patent kojic acid (Japanese Patent Laid-Open No. 56-7710) has excellent whitening effect due to its excellent inhibitory ability of tyrosinase, the only enzyme involved in the transition of tyrosine to dopa and dopachrome. It is being reconsidered in terms of safety.

Another patent arbutin (Japanese Patent Application Laid-Open No. 4-9315) can be obtained from or extracted from bilberry, which is a natural plant material, and is synthesized. As with kojic acid, the ability to inhibit tyrosinase has been proven, but arbutin itself is hydro When sugars are attached to quinones and applied as cosmetics, the skin may be irritated by hydroquinone after sugars are separated by skin enzymes.

Due to this problem in the related art, the development of whitening raw materials which improve safety using many natural products has been attempted.

Accordingly, the present inventors have diligently researched to develop a new cosmetic composition that can reduce skin irritation and enhance the whitening effect. As a result, when using a mixture of lactate and phyrite, the skin irritation caused by lactate is greatly alleviated. By confirming that the effect greatly increased, the present invention was completed.

Accordingly, it is an object of the present invention to provide a whitening cosmetic composition that is alleviated skin irritation and improved whitening effect.

Other objects and advantages of the present invention will become apparent from the following detailed description and claims.

According to an aspect of the present invention, the present invention provides a whitening cosmetic composition comprising lactate and phyrite as active ingredients for whitening.

In the cosmetic composition of the present invention, lactate used as an active ingredient for whitening has been widely used in whitening cosmetics, and has a whitening effect by peeling off keratin that is deposited on the epidermis and makes the face color dull. Such lactate has the advantage of easy penetration into the skin due to its low molecular weight, but there is a problem of causing skin irritation such as erythema and itching in the skin safety part during continuous use.

Accordingly, the present inventors have found that the synergistic effect of the whitening effect and the skin safety are increased when the phytolite is used in combination with lactate to exfoliate the keratin of the skin in the application to the cosmetic to improve the effect of skin safety and whitening. It was.

In the cosmetic composition of the present invention, phytolight as another active ingredient (phytolight) is a term made by combining the prefix "phyto-" meaning plant and "light" meaning whitening action. Means apple extract, golden root extract, camellia leaf extract, cucumber extract or a mixture of said extracts.

The plant extract included in the cosmetic composition of the present invention can be obtained by various extraction methods, and can be obtained by adding an aqueous or organic solvent. Specifically, it is preferable to use a method of obtaining an extract by adding water, anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms, acetone, ethyl acetate, butyl acetate, chloroform, 1,3-butylene glycol, and the like.

According to an embodiment of the present invention, the phytolite may include one of the above extracts, and more preferably includes a combination of two or more of the above extracts.

Apple extract included in the phytolite of the present invention may be prepared from various organs (flowers, fruits, stems, roots, leaves, etc.) of the apple tree, but is preferably extracted from apple fruit. The content of the apple extract is preferably 0.001-10% by weight based on the total phyrite.

The golden extract included in the phytolite of the present invention may be prepared from various organs of gold (flowers, fruits, stems, roots, leaves, etc.), but is preferably extracted from the golden roots. The content of the golden root extract is preferably 0.001-10% by weight based on the total phytolite.

Camellia extract included in the phytolite of the present invention may be prepared from various organs (flowers, fruits, stems, roots, leaves, etc.) of the camellia, but is preferably extracted from the leaves of the camellia. The content of camellia leaves is preferably 0.001-10% by weight based on the total phyrite.

Cucumber extract included in the phytolite of the present invention may be prepared from various organs (flowers, fruits, stems, roots, leaves, etc.) of the cucumber, but is preferably extracted from the fruit of the cucumber. The content of cucumber fruit is preferably 0.001-10% by weight based on the total phyrite.

According to a preferred embodiment of the present invention, the phyrite of the present invention may additionally include EDTA. EDTA functions to inhibit tyrosinase by binding to copper ions, which is a metallic cofactor required to oxidize tyrosine during melanogenesis in phyrite. More preferably EDTA is in the form of a stable salt, such as disodium EDTA.

Thus, the most preferred form of phytolite used in the present invention is apple extract ( Pyrus Malus Fruit Extract), Scutellaria Baicalensis Root Extract, Camellia Sinensis Leaf Extract, Cucumber Extract ( Cucumis Sativus Fruit) Extract) and EDTA-2Na.

Since the phytolite is a plant extract, it not only has excellent safety for the skin but also has an excellent tyrosinase inhibitory ability to serve to make the skin white and transparent. In addition, the inventors have found that phytolite acts to alleviate skin irritation caused by lactate.

It is believed that when low-molecular lactate removes dead skin cells and causes irritation of the stratum corneum, natural phytolite penetrates into the skin while alleviating the irritation, causing synergism of the whitening effect.

Therefore, in the cosmetic composition of the present invention, phytolite has a function of alleviating skin irritation by whitening and lactate.

The lactates used in the compositions of the present invention may take the form of various salts, most preferably sodium lactate. Also, sodium lactate is preferably 50-70% sodium lactate, more preferably 60% sodium lactate.

According to a preferred embodiment of the present invention, the content of sodium lactate and phyrite is 1-20% by weight and 0.001-10% by weight, respectively, based on the total composition. More preferably, the content of sodium lactate and phyrite is 10-18% by weight and 1-5% by weight, respectively.

The components included in the cosmetic composition of the present invention include components conventionally used in cosmetic compositions in addition to lactate and phyrite as active ingredients, and include, for example, conventional agents such as antioxidants, stabilizers, solubilizers, vitamins, pigments and flavorings. Adjuvants, and carriers.

The whitening composition of the present invention may be prepared in any formulation conventionally prepared in the art, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing It may be formulated as cleansing, oil, powder foundation, emulsion foundation, wax foundation, spray, and the like, but is not limited thereto. More specifically, it may be prepared in the form of a flexible lotion, nutrition lotion, nutrition cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray or powder.

When the formulation of the present invention is a paste, cream or gel, animal oils, vegetable oils, waxes, paraffins, starches, trachants, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicas, talc or zinc oxide may be used as carrier components. Can be.

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used, in particular in the case of a spray, additionally chlorofluorohydrocarbon, propane Propellant such as butane or dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, solubilizer or emulsifier is used as the carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 Fatty acid esters of, 3-butylglycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan.

When the formulation of the present invention is a suspension, liquid carrier diluents such as water, ethanol or propylene glycol, suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystals Soluble cellulose, aluminum metahydroxy, bentonite, agar or tracant and the like can be used.

When the formulation of the present invention is a surfactant-containing cleansing, the carrier component is an aliphatic alcohol sulfate, an aliphatic alcohol ether sulfate, a sulfosuccinic acid monoester, isethionate, an imidazolinium derivative, a methyltaurate, a sarcosinate, a fatty acid amide. Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.

The whitening cosmetic composition of the present invention not only maximizes the whitening effect by the cooperative action of lactate and phyrite, but also significantly improves the skin stability by effectively mitigating the skin irritation caused by lactate. .

Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are only for illustrating the present invention in more detail, it is to those skilled in the art that the scope of the present invention is not limited by these examples in accordance with the gist of the present invention. Will be self-evident.

Preparation Example 1

Phytolites having the composition of Table 1 were prepared:

ingredient Content (% by weight) Pyrus Malus (Apple) Fruit Extract 1-5 Scutellaria Baicalensis Root Extract 1-5 Camellia Sinensi s Leaf Extract 1-5 Cucumis Sativus (Cucumber) Fruit Extract 1-5 EDTA-2Na 1-5 Preservative / Additive Sodium Sulfite 2 Sodium Metabisulfite 2

Prescription Example 1

Prescription examples of softening water (skin) in cosmetics containing 60% sodium lactate and phytolite of the present invention are as follows:

ingredient Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Phytolite 2.0 - - 2.0 60% sodium lactate 15.0 - 15.0 - Butylene Glycol 5.0 5.0 5.0 5.0 glycerin 1.0 1.0 1.0 1.0 ethanol 4.0 4.0 4.0 4.0 Polyoxyethylene Hydrogenated Castor Oil 0.4 0.4 0.4 0.4 incense a very small amount a very small amount a very small amount a very small amount antiseptic a very small amount a very small amount a very small amount a very small amount Purified water Remaining amount Remaining amount Remaining amount Remaining amount Total weight 100.0 100.0 100.0 100.0

Prescription Example 2

Formulation examples of milk lotion in cosmetics containing 60% sodium lactate and phytolite of the present invention are as follows:

ingredient Example 2 Comparative Example 4 Comparative Example 5 Comparative Example 6 Phytolite 2.0 - - 2.0 60% sodium lactate 15.0 - 15.0 - Butylene Glycol 3.0 3.0 3.0 3.0 glycerin 3.0 3.0 3.0 3.0 Squalane 4.0 4.0 4.0 4.0 Macadamia Nut Oil 3.0 3.0 3.0 3.0 Tocopheryl Acetate 1.0 1.0 1.0 1.0 Polysorbate 60 1.5 1.5 1.5 1.5 Sorbitan sesquioleate 1.0 1.0 1.0 1.0 Carbomer 0.2 0.2 0.2 0.2 Triethanolamine 0.2 0.2 0.2 0.2 incense a very small amount a very small amount a very small amount a very small amount antiseptic a very small amount a very small amount a very small amount a very small amount Purified water Remaining amount Remaining amount Remaining amount Remaining amount Total weight 100.0 100.0 100.0 100.0

Prescription Example 3

Prescription examples of nutritional creams in cosmetics containing 60% sodium lactate and phytolite of the present invention are as follows:

ingredient Example 3 Comparative Example 7 Comparative Example 8 Comparative Example 9 Phytolite 2.0 - - 2.0 60% sodium lactate 15.0 - 15.0 - Butylene Glycol 2.0 2.0 2.0 2.0 glycerin 5.0 5.0 5.0 5.0 Squalane 4.0 4.0 4.0 4.0 Macadamia Nut Oil 3.0 3.0 3.0 3.0 Cetearyl Alcohol 1.0 1.0 1.0 1.0 Beeswax 1.0 1.0 1.0 1.0 Tocopheryl Acetate 1.0 1.0 1.0 1.0 Polysorbate 60 2.0 2.0 2.0 2.0 Sorbitan sesquioleate 1.6 1.6 1.6 1.6 Carbomer 0.5 0.5 0.5 0.5 Triethanolamine 0.5 0.2 0.2 0.2 incense a very small amount a very small amount a very small amount a very small amount antiseptic a very small amount a very small amount a very small amount a very small amount Purified water Remaining amount Remaining amount Remaining amount Remaining amount Total weight 100.0 100.0 100.0 100.0

In order to measure the whitening effect and skin safety, Examples 1, 2 and 3 and Comparative Examples 1-9 were prepared. As shown in the characteristics of the prescription, the prescription using sodium lactate and phytolite, respectively, and the unused prescription were set as comparative examples. Skin safety and whitening effect of the cosmetic composition prepared according to the above Examples and Comparative Examples were measured, respectively.

Test Example 1: Skin irritation test

In order to determine the skin irritation of the products prepared according to the above examples and comparative examples, 50 healthy adults males and females were placed in a constant amount (about 0.1g) of each sample at 5 x 20 cm in the lower arm of both arms. After patching for 24 hours, the skin condition changes were visually read after 1 hour and 24 hours after removal, and the results are shown in Table 2. Criteria and stimulus calculation methods are as follows:

* Criteria *

-No erythema or unusual symptoms; +-: Slightly redder than the surroundings

+: Significantly redder than surroundings ++: Severe reddening and swelling around

Stimulus rate = [{(+-) number x 1 + (+) number x 2 + (++) number x 3} / {total number of subjects x3}] x 100

Prescription Number of test subjects Judgment result Stimulus% ++ + +- - Example 1 50 0 One 6 44 5.3 Example 2 50 0 0 5 46 3.3 Example 3 50 0 0 4 47 2.7 Comparative Example 1 50 0 0 4 46 2.7 Comparative Example 2 50 0 3 7 42 8.7 Comparative Example 3 50 0 0 5 45 3.3 Comparative Example 4 50 0 0 3 27 2.0 Comparative Example 5 50 0 2 6 24 6.7 Comparative Example 6 50 0 0 4 26 2.7 Comparative Example 7 50 0 0 One 49 0.7 Comparative Example 8 50 0 2 5 45 6.0 Comparative Example 9 50 0 0 2 48 1.3

As can be seen from the skin irritation test results in the table, it can be seen that Examples 1, 2, and 3 show normal irritation degree compared to Comparative Examples 1-9. In particular, compared to Comparative Examples 2, 5, and 8 showed a very low degree of stimulation.

More specifically, Comparative Examples 2, 5 and 8 are compositions comprising sodium lactate, which have a very high skin irritation caused by sodium lactate (8.7, 6.7 and 6.0, respectively). However, the results of Examples 1, 2 and 3 of the present invention, it can be seen that the skin irritation caused by sodium lactate is greatly reduced by phyrite.

Thus, it can be seen that phytolite can function to reduce skin irritation caused by sodium lactate in the cosmetic composition.

Test Example 2: Measurement of Whitening Effect

Thirty volunteers of Korean women aged 19-40 years old were selected. In particular, the women's skin of volunteers was targeted for women with dark skin. Minolta CR 300 was used as a measuring instrument and measured at 2 week intervals for 2 months. The measurement sites were marked with 1 cm of width and length on 9 arms, and 8 different prescriptions (Examples 2, 3 and Comparative Examples 4-9) were continuously applied and one was placed as a control value for comparison. The difference from the control is shown in Table 6.

division Example 2 Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Comparative Example 7 Comparative Example 8 Comparative Example 9 Control ΔL value 3.75 4.25 0.50 2.00 1.50 0.50 2.00 1.75 0.00

As can be seen from Table 6, it can be seen that the ΔL value after 8 weeks is higher in Examples 2 and 3 than Comparative Examples 4-9 and the control. That is, it can be seen that the composition of the present invention comprising phyrite and sodium lactate has a significantly increased whitening effect compared to conventional whitening cosmetic compositions.

As described in detail above, the present invention provides a whitening cosmetic composition comprising lactate and phytolite as an active ingredient for whitening. The whitening cosmetic composition of the present invention not only maximizes the whitening effect by the joint action of lactate and phyrite, but also significantly improves the skin stability by effectively mitigating the skin irritation caused by lactate. .

Claims (7)

A whitening cosmetic composition comprising lactate and phytolite as active ingredients for whitening. According to claim 1, wherein the lactate is a whitening cosmetic composition, characterized in that sodium lactate. The whitening cosmetic composition of claim 1, wherein the phytolite has a function of alleviating skin irritation caused by lactating and whitening. 2. The whitening cosmetic composition according to claim 1, wherein the content of lactate and phyrite is 1-20 wt% and 0.001-10 wt%, respectively, based on the total composition. The method of claim 1, wherein the phyrite is apple extract (Pyrus MalusFruitextract), Golden Root Extract (Scutellaria BaicalensisRoot extract), Camellia leaf extract (Camellia sinensisLeaf extract), cucumber extract (Cucumis sativusFruit extract) and a whitening cosmetic composition, characterized in that the extract is selected from the group consisting of. The whitening cosmetic composition according to claim 5, wherein the extract further comprises EDTA-2Na. The composition of claim 1 wherein the cosmetic composition consists of a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation and spray Whitening cosmetic composition, characterized in that it has a formulation selected from the group.